TY - JOUR T1 - Visual and proprioceptive feedback improves knee joint position sense AN - 954610455; 14081271 AB - Joint position sense (JPS), one method to assess proprioception, is the ability to replicate a target limb position. Feedback is commonly used to improve motor performance but it has not been demonstrated to improve JPS. The purpose of this study was to determine if feedback decreases error associated with knee JPS at three movement velocities. Healthy volunteers sat with their hip and knees flexed. The knee was passively extended at three velocities (0.5, 2, and 10 degree /s). Subjects were instructed to stop knee motion, via a thumb switch, at a 20 degree knee flexion target. Following movement, each subject received visual and proprioceptive feedback indicating final leg position relative to the target position. Movement velocities and times (4s, 5s, 6s) were randomly presented so subjects could not predict the target position. Measures of JPS included constant error (CE), absolute error (AE), variable error (VE), and percent correct (%CORR). Significant decreases in CE, AE, and VE as well as an increase in %CORR were demonstrated. The majority of JPS improvement (85%) occurred by the tenth trial. Short-term improvements in JPS may be the result of temporary CNS adaptations via feedback that was provided to subjects. Long-term learning of JPS enhancement needs further investigation. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Brindle, Timothy J AU - Mizelle, J C AU - Lebiedowska, Maria K AU - Miller, Jeri L AU - Stanhope, Steven J AD - Biomechanics Laboratory, National Institutes of Health, Building 10 CRC, Room 1-1469 10 Center Drive MCS 1604, Bethesda, MD, 20892, USA, Tbrindle@cc.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 40 EP - 47 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 17 IS - 1 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Feedback KW - Fingers KW - Hips KW - Joints KW - Knees KW - Movement KW - Sports KW - Surgery KW - Velocity KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954610455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=Visual+and+proprioceptive+feedback+improves+knee+joint+position+sense&rft.au=Brindle%2C+Timothy+J%3BMizelle%2C+J+C%3BLebiedowska%2C+Maria+K%3BMiller%2C+Jeri+L%3BStanhope%2C+Steven+J&rft.aulast=Brindle&rft.aufirst=Timothy&rft.date=2009-01-01&rft.volume=17&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-008-0638-3 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Fingers; Surgery; Knees; Velocity; Feedback; Sports; Movement; Hips; Joints DO - http://dx.doi.org/10.1007/s00167-008-0638-3 ER - TY - JOUR T1 - A Comprehensive Review of the Literature on Exposure to Metalworking Fluids AN - 899165765; 15153489 AB - An extensive literature review was conducted of studies with exposure measurements to metalworking fluids (MWFs). A database of 155 arithmetic means based on 9379 aerosol measurements from published studies was compiled. Weighted arithmetic means (WAMs) and their variance calculated across studies were summarized based on decade (prior to 1970s through 2000s), industry (auto, auto parts, small job shops, and others), operation (grinding and machining), and fluid type (straight, soluble, synthetic, and semisynthetic). Total mass and total extractable mass measurements that were simultaneously collected were compared. Average concentrations by size fractions and mass median aerodynamic diameters (MMADs) were also analyzed. Analysis of the WAMs indicated a reduction in exposure levels over time regardless of industry or type of operation or fluid, with mean levels prior to the 1970s of 5.4 mg/m3, which dropped to 2.5 mg/m3 in the 1970s, to 1.2 mg/m3 in the 1980s, and to 0.5 mg/m3 in the 1990s. No further reduction was seen in the 2000s. A comparison by industry, operation, and fluid type found no consistent patterns in the measurement results. The percent extractable mass in the total aerosol samples varied by fluid type, with an average 84% in straight fluids, 58% in synthetic fluids, 56% in soluble fluids, and 42% in the semisynthetic fluids. Exposure means from the thoracic fraction (0.3-0.5 mg/m3) were slightly less than those for total aerosol for both the 1990s and 2000s, the only decades for which thoracic data were available. Respirable means did not change from the 1980s to the 2000s (generally about 0.2-0.3 mg/m3). The MMADs of the MWF aerosols averaged 4-6 Delta *mm. These measurement data indicate a clear reduction of exposure levels over time. They will be used for the retrospective assessment of exposure levels to MWFs in a population-based, case-control study of bladder cancer. JF - Journal of Occupational and Environmental Hygiene AU - Park, Donguk AU - Stewart, Patricia A AU - Coble, Joseph B AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts KW - urinary bladder KW - Aerosols KW - Reviews KW - Aerodynamics KW - metal-working fluids KW - Air sampling KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899165765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=A+Comprehensive+Review+of+the+Literature+on+Exposure+to+Metalworking+Fluids&rft.au=Park%2C+Donguk%3BStewart%2C+Patricia+A%3BCoble%2C+Joseph+B&rft.aulast=Park&rft.aufirst=Donguk&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903065984 L2 - http://www.informaworld.com/smpp/content~db=all~content=a912533614~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - urinary bladder; Aerosols; Aerodynamics; Reviews; Air sampling; metal-working fluids DO - http://dx.doi.org/10.1080/15459620903065984 ER - TY - JOUR T1 - Safety and efficacy of antipsychotic drugs for the behavioral and psychological symptoms of dementia AN - 872139349; 14606947 AB - Antipsychotic drugs are commonly used in the treatment of the behavioral and psychological symptoms of dementia (BPSD). We present a qualitative review of the data on the efficacy and safety of antipsychotic drugs for BPSD. We more specifically examine safety issues with an especial focus on recent research. We examine two safety studies in detail to provide readers with a critical perspective. Typical and atypical antipsychotic drugs both attenuate the severity of BPSD; however, both categories of drugs increase the risk of cerebrovascular and other adverse events, as well as the risk of death. The risk appears greater with the typical drugs, with higher doses, and during the initial weeks of treatment. The risk probably persists for as long as a year after the initiation of treatment. Both drug- and patient-related factors appear to mediate this increase in risk. Antipsychotic drugs should be considered for BPSD only if there is a specific need, or if other treatments have failed; decision-making should be individualized and documented after a risk-benefit analysis. Atypical antipsychotics appear safer than the typical drugs. The lowest effective dose should be used. JF - Indian Journal of Psychiatry AU - Andrade, Chittaranjan AU - Radhakrishnan, Rajiv AD - Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India Y1 - 2009/01// PY - 2009 DA - January 2009 SP - S87 EP - S92 PB - Medknow Publications Pvt. Ltd., A-108/109 Kanara Business Center Mumbai 400075 India VL - 51 IS - 1 SN - 0019-5545, 0019-5545 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Antipsychotics KW - dementia KW - behavioral and psychological symptoms of dementia KW - mortality KW - stroke KW - Risk assessment KW - Mortality KW - Data processing KW - Psychology KW - Decision making KW - Dose-response effects KW - Neuroleptics KW - Reviews KW - Dementia disorders KW - dementia disorders KW - Drugs KW - Side effects KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872139349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Psychiatry&rft.atitle=Safety+and+efficacy+of+antipsychotic+drugs+for+the+behavioral+and+psychological+symptoms+of+dementia&rft.au=Andrade%2C+Chittaranjan%3BRadhakrishnan%2C+Rajiv&rft.aulast=Andrade&rft.aufirst=Chittaranjan&rft.date=2009-01-01&rft.volume=51&rft.issue=1&rft.spage=S87&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Psychiatry&rft.issn=00195545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Risk assessment; Decision making; Data processing; Reviews; Neuroleptics; Dementia disorders; Drugs; Mortality; Psychology; Dose-response effects; dementia disorders; Side effects ER - TY - JOUR T1 - The contribution of the Department of Veterans Affairs to neuroimaging of aphasia: One perspective AN - 85348357; llba-200920515 AB - Background: The Department of Veterans Affairs (VA) has made important contributions to the neuroimaging of aphasia. Through the affiliations of VA researchers with medical faculties, a broad range of questions has been addressed regarding the structural, metabolic, and functional changes that occur in the brain of individuals who develop aphasia. Aims: This report examines some of the work that has been accomplished by VA researchers using CT, MRI, SPECT, and PET imaging approaches. Main Contribution and Conclusions: The reviewed VA research demonstrates that aphasia results from the dynamic relationships that exist between the impact of structural brain damage on brain function in both damaged and non-damaged regions of the brain. The resulting concepts have led to innovative strategies for the neurorehabilitation of aphasia. Adapted from the source document JF - Aphasiology AU - Metter, Jeffrey E AU - Mlcoch, Anthony AD - National Institute on Aging, Baltimore, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1086 EP - 1100 VL - 23 IS - 9 SN - 0268-7038, 0268-7038 KW - *Aphasia (03400) KW - *Magnetic Resonance Imaging (MRI) (50620) KW - *Neuroimaging Techniques (57245) KW - *Medicine (52500) KW - *Armed Forces (04200) KW - *Brain Damage (09400) KW - *Positron Emission Tomography (PET) (66813) KW - article KW - 6414: language-pathological and normal; aphasia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85348357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=The+contribution+of+the+Department+of+Veterans+Affairs+to+neuroimaging+of+aphasia%3A+One+perspective&rft.au=Metter%2C+Jeffrey+E%3BMlcoch%2C+Anthony&rft.aulast=Metter&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=23&rft.issue=9&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-12-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Neuroimaging Techniques (57245); *Medicine (52500); *Magnetic Resonance Imaging (MRI) (50620); *Positron Emission Tomography (PET) (66813); *Brain Damage (09400); *Armed Forces (04200) ER - TY - JOUR T1 - Targeting Protein Kinase C (PKC) and Telomerase by Phenethyl Isothiocyanate (PEITC) Sensitizes PC-3 Cells Towards Chemotherapeutic Drug-Induced Apoptosis AN - 746078779; 12926388 AB - Prostate cancer is the leading cause of cancer-related death in men, incidences of which are increasing gradually in India. Protein kinase C (PKC), an enzyme, gets overexpressed in prostate cancer and results in a resistance to chemotherapy. Telomerase, a reverse transcriptase, is highly activated in prostate cancer cells. Both of these enzymes can be considered as potential molecular markers for prostate cancer. The present study investigates the effects of natural isothiocyanate phenethyl isothiocyanate (PEITC) in modulating the activities of PKC and telomerase in the androgen-independent human prostate adenocarcinoma (PC-3) cell line. We observed that PEITC downregulated the antiapoptotic isoforms (PKC alpha and epsilon) efficiently and zeta moderately. Basal level of PKC delta, a proapoptotic form, was very poor and its modulation was not significant. PEITC also inhibited the activity of telomerase. Studies were conducted to measure the degree of apoptotic cell death induced either by PEITC alone or in combination with adriamycin or etoposide. Apoptosis was evident from the release of mitochondrial cytochrome c, apoptotic index, and by the induction of caspases 3 and 8. PEITC exhibited remarkable efficacy in sensitizing PC-3 cells to undergo cell death by adriamycin and etoposide, which might prove to be of considerable value in synergistic therapy of cancer. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Mukherjee, Sutapa AU - Bhattacharya, Rathindra Kumar AU - Roy, Madhumita AD - Department of Environmental Carcinogenesis & Toxicology, Chittaranjan National Cancer Institute, Kolkata 700 026 Y1 - 2009 PY - 2009 DA - 2009 SP - 269 EP - 282 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 USA VL - 28 IS - 4 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Pollution Abstracts KW - Protein kinase C KW - Apoptosis KW - Pathology KW - Telomerase KW - Chemotherapy KW - Mitochondria KW - Tumor cell lines KW - ISW, India KW - Cytochrome c KW - phenethyl isothiocyanate KW - deltas KW - RNA-directed DNA polymerase KW - prostate cancer KW - Etoposide KW - isothiocyanate KW - Mortality KW - Enzymes KW - Cancer KW - chemotherapy KW - Cytochrome KW - Prostate cancer KW - Caspase-3 KW - Proteins KW - Adenocarcinoma KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746078779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Targeting+Protein+Kinase+C+%28PKC%29+and+Telomerase+by+Phenethyl+Isothiocyanate+%28PEITC%29+Sensitizes+PC-3+Cells+Towards+Chemotherapeutic+Drug-Induced+Apoptosis&rft.au=Mukherjee%2C+Sutapa%3BBhattacharya%2C+Rathindra+Kumar%3BRoy%2C+Madhumita&rft.aulast=Mukherjee&rft.aufirst=Sutapa&rft.date=2009-01-01&rft.volume=28&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Apoptosis; Telomerase; Chemotherapy; Enzymes; Mitochondria; Tumor cell lines; Prostate cancer; Cytochrome c; phenethyl isothiocyanate; Caspase-3; RNA-directed DNA polymerase; Adenocarcinoma; Etoposide; isothiocyanate; Mortality; Cytochrome; Pathology; deltas; Proteins; prostate cancer; chemotherapy; Cancer; ISW, India ER - TY - JOUR T1 - Research Misconduct Policies of Scientific Journals AN - 746009558; 13054696 AB - The purpose of this study was to gather information on the misconduct policies of scientific journals. We contacted editors from a random sample of 399 journals drawn from the ISI Web of Knowledge database. We received 197 responses (49.4% response rate): 54.8% had a policy, and 47.7% had a formal (written) policy; 28.9% had a policy that only outlined procedures for handling misconduct, 15.7% had a policy that only defined misconduct, 10.2% had a policy that included both a definition and procedures; 26.9% of journals had a policy that was generated by the publisher, 13.2% had a policy that was generated by the journal, and 14.7% had a policy that was generated by another source, such as a professional association. We analyzed the relationship between having a policy and impact factor, field of science, publishing house, and nationality. Impact factor was the only variable with a statistically significant association with having a policy. Impact factor was slightly positively associated with whether or not the publisher had a policy, with an odds ratio of 1.49 (P < .0004) per 10 units increase in the impact factor, with a 95% confidence interval (1.20, 1.88). Our research indicates that more than half of scientific journals have developed misconduct policies, but that most of these policies do not define research misconduct and most of these policies were not generated by the journal. JF - Accountability in Research AU - Resnik J.D., DB AU - Peddada, S AU - Brunson, W Jr AD - National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, North Carolina, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 254 EP - 267 VL - 16 IS - 5 SN - 0898-9621, 0898-9621 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746009558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accountability+in+Research&rft.atitle=Research+Misconduct+Policies+of+Scientific+Journals&rft.au=Resnik+J.D.%2C+DB%3BPeddada%2C+S%3BBrunson%2C+W+Jr&rft.aulast=Resnik+J.D.&rft.aufirst=DB&rft.date=2009-01-01&rft.volume=16&rft.issue=5&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Accountability+in+Research&rft.issn=08989621&rft_id=info:doi/10.1080%2F08989620903190299 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/08989620903190299 ER - TY - JOUR T1 - Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers AN - 745698870; 13028073 AB - Organophosphate (OP) and N-methyl-carbamate (CB) insecticides are widely used in agriculture in the US and abroad. These compounds - which inhibit acetylcholinestersase (AChE) enzyme activity - continue to be responsible for a high proportion of pesticide poisonings among US agricultural workers. It is possible that some individuals may be especially susceptible to health effects related to OP/CB exposure. The paraoxonase (PON1) enzyme metabolizes the highly toxic oxon forms of some OPs, and an individual's PON1 status may be an important determinant of his or her sensitivity to these chemicals. This chapter discusses methods used to characterize the PON1 status of individuals and reviews previous epidemiologic studies that have evaluated PON1-related sensitivity to OPs in relation to various health endpoints. It also describes an ongoing longitudinal study among OP-exposed agricultural pesticide handlers who are participating in a recently implemented cholinesterase monitoring program in Washington State. This study will evaluate handlers' PON1 status as a hypothesized determinant of butyrylcholinesterase (BuChE) inhibition. Such studies will be useful to determine how regulatory risk assessments might account for differences in PON1-related OP sensitivity when characterizing inter-individual variability in risk related to OP exposure. Recent work assessing newer and more sensitive biomarkers of OP exposure is also discussed briefly in this chapter. JF - Advances in Experimental Medicine and Biology AU - Hofmann, J N AU - Keifer, M C AU - Checkoway, H AU - De Roos, AJ AU - Farin, F M AU - Fenske, R A AU - Richter, R J AU - van Belle, G AU - Furlong, CE AD - Division of Cancer Epidemilogy and Genetics, National Cancer Institute, Bethesda, MD, USA, hofmannjn@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 19 EP - 28 VL - 660 SN - 0065-2598, 0065-2598 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Agriculture KW - Risk assessment KW - Poisoning KW - Handlers KW - Enzymes KW - Aryldialkylphosphatase KW - organophosphates KW - Cholinesterase KW - biomarkers KW - Insecticides KW - Pesticides KW - Occupational exposure KW - W 30940:Products KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745698870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Experimental+Medicine+and+Biology&rft.atitle=Biomarkers+of+Sensitivity+and+Exposure+in+Washington+State+Pesticide+Handlers&rft.au=Hofmann%2C+J+N%3BKeifer%2C+M+C%3BCheckoway%2C+H%3BDe+Roos%2C+AJ%3BFarin%2C+F+M%3BFenske%2C+R+A%3BRichter%2C+R+J%3Bvan+Belle%2C+G%3BFurlong%2C+CE&rft.aulast=Hofmann&rft.aufirst=J&rft.date=2009-01-01&rft.volume=660&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Advances+in+Experimental+Medicine+and+Biology&rft.issn=00652598&rft_id=info:doi/10.1007%2F978-1-60761-350-3_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Agriculture; Insecticides; Pesticides; Poisoning; Aryldialkylphosphatase; Enzymes; Handlers; organophosphates; Cholinesterase; biomarkers; Occupational exposure DO - http://dx.doi.org/10.1007/978-1-60761-350-3_3 ER - TY - JOUR T1 - Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent AN - 744698970; 11741218 AB - Background The obligate intracellular bacterial pathogen Coxiella burnetii causes the zoonosis Q fever. The intracellular niche of C. burnetii has led to the assumption that cell-mediated immunity is the most important immune component for protection against this pathogen. However, passive immunization with immune serum can protect naive animals from challenge with virulent C. burnetii, indicating a role for antibody (Ab) in protection. The mechanism of this Ab-mediated protection is unknown. Therefore, we conducted a study to determine whether Fc receptors (FcR) or complement contribute to Ab-mediated immunity (AMI) to C. burnetii. Results Virulent C. burnetii infects and replicates within human dendritic cells (DC) without inducing their maturation or activation. We investigated the effects of Ab opsonized C. burnetii on human monocyte-derived and murine bone marrow-derived DC. Infection of DC with Ab-opsonized C. burnetii resulted in increased expression of maturation markers and inflammatory cytokine production. Bacteria that had been incubated with naive serum had minimal effect on DC, similar to virulent C. burnetii alone. The effect of Ab opsonized C. burnetii on DC was FcR dependent as evidenced by a reduced response of DC from FcR knockout (FcR k/o) compared to C57Bl/6 (B6) mice. To address the potential role of FcR in Ab-mediated protection in vivo, we compared the response of passively immunized FcR k/o mice to the B6 controls. Interestingly, we found that FcR are not essential for AMI to C. burnetii in vivo. We subsequently examined the role of complement in AMI by passively immunizing and challenging several different strains of complement-deficient mice and found that AMI to C. burnetii is also complement-independent. Conclusion Despite our data showing FcR-dependent stimulation of DC in vitro, Ab-mediated immunity to C. burnetii in vivo is FcR-independent. We also found that passive immunity to this pathogen is independent of complement. JF - BMC Immunology AU - Shannon, Jeffrey G AU - Cockrell, Diane C AU - Takahashi, Kazue AU - Stahl, Gregory L AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA, rheinzen@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 26 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bacteria KW - Immune serum KW - Data processing KW - Bone marrow KW - Pathogens KW - Infection KW - Cell activation KW - Fc receptors KW - Inflammation KW - Immunity (passive) KW - Coxiella burnetii KW - Dendritic cells KW - Antibodies KW - Immunity (cell-mediated) KW - Cytokines KW - Immunization (passive) KW - Monocytes KW - Q fever KW - Opsonization KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744698970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Immunology&rft.atitle=Antibody-mediated+immunity+to+the+obligate+intracellular+bacterial+pathogen+Coxiella+burnetii+is+Fc+receptor-+and+complement-independent&rft.au=Shannon%2C+Jeffrey+G%3BCockrell%2C+Diane+C%3BTakahashi%2C+Kazue%3BStahl%2C+Gregory+L%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=10&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=BMC+Immunology&rft.issn=1471-2172&rft_id=info:doi/10.1186%2F1471-2172-10-26 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2017-02-01 N1 - SubjectsTermNotLitGenreText - Data processing; Immune serum; Bone marrow; Pathogens; Infection; Inflammation; Fc receptors; Cell activation; Immunity (passive); Dendritic cells; Antibodies; Immunity (cell-mediated); Cytokines; Immunization (passive); Monocytes; Q fever; Opsonization; Coxiella burnetii; Bacteria DO - http://dx.doi.org/10.1186/1471-2172-10-26 ER - TY - JOUR T1 - Chronic Exposures to Cholinesterase-inhibiting Pesticides Adversely Affect Respiratory Health of Agricultural Workers in India AN - 744670208; 12554778 AB - Objective: The impact of long term exposure to cholinesterase (ChE)- inhibiting organophosphate (OP) and carbamate (C) pesticides on the respiratory health of agricultural workers in India was investigated. Methods: Three hundred and seventy-six nonsmoking agricultural workers (median age 41 yr) from eastern India who sprayed OP and C pesticides in the field and 348 age- and sex-matched control subjects with non-agricultural occupations from the same locality were enrolled. Prevalence of respiratory symptoms was obtained by questionnaire survey, and pulmonary function tests were carried out by spirometry. Chronic obstructive pulmonary disease (COPD) was diagnosed by the Global Obstructive Lung Disease (GOLD) criteria, and erythrocyte acetylcholinesterase (AChE) was measured by the Ellman method. Results: Agricultural workers had greater prevalences of upper and lower respiratory symptoms, and appreciable reduction in spirometric measurements. Overall, lung function reduction was noted in 48.9% of agricultural workers compared with 22.7% of control, and a restrictive type of deficit was predominant. COPD was diagnosed in 10.9% of agricultural workers compared with 3.4% of controls (p-0.05 in [chi] super(2) test), and the severity of the disease was greater in agricultural workers. Red blood cell (RBC) AChE was lowered by 34.2% in agricultural workers, and the fall in AChE level was positively associated with respiratory symptoms, lung function decrement and COPD after controlling for education and income as potential confounders. Conclusions: Long-term exposure to cholinesterase-inhibiting agricultural pesticides currently in use in India is associated with a reduction in lung function, COPD and a rise in respiratory symptoms. JF - Journal of Occupational Health AU - Chakraborty, Sreeparna AU - Mukherjee, Sayali AU - Roychoudhury, Sanghita AU - Siddique, Shabana AU - Lahiri, Twisha AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute Y1 - 2009 PY - 2009 DA - 2009 SP - 488 EP - 497 PB - Japan Society for Occupational Health, Public Health Bldg., 1-29-8 Shinjuku Shinjuku-ku Tokyo 190 Japan VL - 51 IS - 6 SN - 1341-9145, 1341-9145 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Acetylcholinesterase KW - Occupational exposure KW - India KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744670208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Health&rft.atitle=Chronic+Exposures+to+Cholinesterase-inhibiting+Pesticides+Adversely+Affect+Respiratory+Health+of+Agricultural+Workers+in+India&rft.au=Chakraborty%2C+Sreeparna%3BMukherjee%2C+Sayali%3BRoychoudhury%2C+Sanghita%3BSiddique%2C+Shabana%3BLahiri%2C+Twisha%3BRay%2C+Manas+Ranjan&rft.aulast=Chakraborty&rft.aufirst=Sreeparna&rft.date=2009-01-01&rft.volume=51&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health&rft.issn=13419145&rft_id=info:doi/10.1539%2Fjoh.L9070 L2 - http://www.jstage.jst.go.jp/article/joh/51/6/488/_pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Occupational exposure; India DO - http://dx.doi.org/10.1539/joh.L9070 ER - TY - JOUR T1 - Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic AN - 744615758; 13002509 AB - In recent years, various nanotechnology platforms in the area of medical biology, including both diagnostics and therapy, have gained remarkable attention. Moreover, research and development of engineered multifunctional nanoparticles as pharmaceutical drug carriers have spurred exponential growth in applications to medicine in the last decade. Design principles of these nanoparticles, including nanoemulsions, dendrimers, nano-gold, liposomes, drug-carrier conjugates, antibody-drug complexes, and magnetic nanoparticles, are primarily based on unique assemblies of synthetic, natural, or biological components, including but not limited to synthetic polymers, metal ions, oils, and lipids as their building blocks. However, the potential success of these particles in the clinic relies on consideration of important parameters such as nanoparticle fabrication strategies, their physical properties, drug loading efficiencies, drug release potential, and, most importantly, minimum toxicity of the carrier itself. Among these, lipid-based nanoparticles bear the advantage of being the least toxic for in vivo applications, and significant progress has been made in the area of DNA/RNA and drug delivery using lipid-based nanoassemblies. In this review, we will primarily focus on the recent advances and updates on lipid-based nanoparticles for their projected applications in drug delivery. We begin with a review of current activities in the field of liposomes (the so-called honorary nanoparticles), and challenging issues of targeting and triggering will be discussed in detail. We will further describe nanoparticles derived from a novel class of amphipathic lipids called bolaamphiphiles with unique lipid assembly features that have been recently examined as drug/DNA delivery vehicles. Finally, an overview of an emerging novel class of particles (based on lipid components other than phospholipids), solid lipid nanoparticles and nanostructured lipid carriers will be presented. We conclude with a few examples of clinically successful formulations of currently available lipid-based nanoparticles. JF - Critical Reviews in Therapeutic Drug Carrier Systems AU - Puri, Anu AU - Loomis, Kristin AU - Smith, Brandon AU - Lee, Jae-Ho AU - Yavlovich, Amichai AU - Heldman, Eliahu AU - Blumenthal, Robert AD - Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 523 EP - 580 PB - Begell House Inc. VL - 26 IS - 6 SN - 0743-4863, 0743-4863 KW - Biotechnology and Bioengineering Abstracts KW - Ions KW - Metals KW - Drug delivery KW - Lipids KW - Oils KW - Toxicity KW - Liposomes KW - RNA KW - Reviews KW - DNA KW - Pharmaceuticals KW - nanoparticles KW - Phospholipids KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744615758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Therapeutic+Drug+Carrier+Systems&rft.atitle=Lipid-Based+Nanoparticles+as+Pharmaceutical+Drug+Carriers%3A+From+Concepts+to+Clinic&rft.au=Puri%2C+Anu%3BLoomis%2C+Kristin%3BSmith%2C+Brandon%3BLee%2C+Jae-Ho%3BYavlovich%2C+Amichai%3BHeldman%2C+Eliahu%3BBlumenthal%2C+Robert&rft.aulast=Puri&rft.aufirst=Anu&rft.date=2009-01-01&rft.volume=26&rft.issue=6&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Therapeutic+Drug+Carrier+Systems&rft.issn=07434863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Drug delivery; Metals; Ions; Lipids; Oils; Toxicity; Liposomes; RNA; Reviews; DNA; Pharmaceuticals; nanoparticles; nanotechnology; Phospholipids ER - TY - JOUR T1 - Social Media Use in the United States: Implications for Health Communication AN - 742900242; 201006703 AB - Background: Given the rapid changes in the communication landscape brought about by participative Internet use and social media, it is important to develop a better understanding of these technologies and their impact on health communication. The first step in this effort is to identify the characteristics of current social media users. Up-to-date reporting of current social media use will help monitor the growth of social media and inform health promotion/communication efforts aiming to effectively utilize social media. Objective: The purpose of the study is to identify the sociodemographic and health-related factors associated with current adult social media users in the United States. Results: Approximately 69% of US adults reported having access to the Internet in 2007. Among Internet users, 5% participated in an online support group, 7% reported blogging, and 23% used a social networking site. Multivariate analysis found that younger age was the only significant predictor of blogging and social networking site participation; a statistically significant linear relationship was observed, with younger categories reporting more frequent use. Younger age, poorer subjective health, and a personal cancer experience predicted support group participation. In general, social media are penetrating the US population independent of education, race/ethnicity, or health care access. Conclusions: Recent growth of social media is not uniformly distributed across age groups; therefore, health communication programs utilizing social media must first consider the age of the targeted population to help ensure that messages reach the intended audience. While racial/ethnic and health statusrelated disparities exist in Internet access, among those with Internet access, these characteristics do not affect social media use. This finding suggests that the new technologies, represented by social media, may be changing the communication pattern throughout the United States. Adapted from the source document. JF - Journal of Medical Internet Research AU - ChoU, Wen-ying Sylvia AU - Hunt, Yvonne M AU - Beckjord, Ellen Burke AU - Moser, Richard P AU - Hesse, Bradford W AD - National Cancer Institute, Health Communication and Informatics Research Branch, 6130 Executive Blvd (EPN), 4051A, Bethesda, MD 20892-7365 Email: chouws@mail.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth Innovation, Toronto, Canada VL - 11 IS - 4 SN - 1438-8871, 1438-8871 KW - USA KW - Internet KW - social media KW - social networking KW - demography KW - population surveillance KW - eHealth, new technologies KW - health communication KW - Web 2.0 KW - Social networks KW - Consumer health information KW - article KW - 14.11: COMMUNICATIONS AND INFORMATION TECHNOLOGY - NETWORKS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742900242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Social+Media+Use+in+the+United+States%3A+Implications+for+Health+Communication&rft.au=ChoU%2C+Wen-ying+Sylvia%3BHunt%2C+Yvonne+M%3BBeckjord%2C+Ellen+Burke%3BMoser%2C+Richard+P%3BHesse%2C+Bradford+W&rft.aulast=ChoU&rft.aufirst=Wen-ying&rft.date=2009-01-01&rft.volume=11&rft.issue=4&rft.spage=NP&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/ L2 - http://www.jmir.org/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumer health information; Internet; Social networks; Web 2.0 ER - TY - JOUR T1 - Neurotrapping: cellular screens to identify the neural substrates of behavior in Drosophila. AN - 734164854; 19949456 AB - The availability of new tools for manipulating neuronal activity, coupled with the development of increasingly sophisticated techniques for targeting these tools to subsets of cells in living, behaving animals, is permitting neuroscientists to tease apart brain circuits by a method akin to classical mutagenesis. Just as mutagenesis can be used to introduce changes into an organism's DNA to identify the genes required for a given biological process, changes in activity can be introduced into the nervous system to identify the cells required for a given behavior. If the changes are introduced randomly, the cells can be identified without any prior knowledge of their properties. This strategy, which we refer to here as "neurotrapping," has been implemented most effectively in Drosophila, where transgenes capable of either suppressing or stimulating neuronal activity can be reproducibly targeted to arbitrary subsets of neurons using so-called "enhancer-trap" techniques. By screening large numbers of enhancer-trap lines, experimenters have been able to identify groups of neurons which, when suppressed (or, in some cases, activated), alter a specific behavior. Parsing these groups of neurons to identify the minimal subset required for generating a behavior has proved difficult, but emerging tools that permit refined transgene targeting are increasing the resolution of the screening techniques. Some of the most recent neurotrapping screens have identified physiological substrates of behavior at the single neuron level. JF - Frontiers in molecular neuroscience AU - White, Benjamin H AU - Peabody, Nathan C AD - Laboratory of Molecular Biology, National Institute of Mental Health Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 20 VL - 2 KW - excitability KW - synaptic KW - genetic KW - neural networks KW - circuits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734164854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Public+Health&rft.atitle=Gene+by+Environment+Interaction+in+Asthma&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Public+Health&rft.issn=01637525&rft_id=info:doi/10.1146%2Fannurev.publhealth.031308.100151 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2009-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Front Mol Neurosci. 2009;2:13 [19750193] Neuron. 2009 Aug 13;63(3):305-15 [19679071] Front Mol Neurosci. 2009;2:21 [19915728] Proc Natl Acad Sci U S A. 1990 Oct;87(20):7844-8 [2236000] Neuron. 1995 Feb;14(2):341-51 [7857643] J Neurosci. 2001 Mar 1;21(5):1523-31 [11222642] Trends Neurosci. 2001 May;24(5):251-4 [11311363] Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12602-7 [11675496] J Neurobiol. 2002 Feb 15;50(3):221-33 [11810637] Cell. 2002 May 17;109(4):485-95 [12086605] J Neurobiol. 2003 May;55(2):233-46 [12672020] Neuron. 2004 May 27;42(4):553-66 [15157418] J Neurobiol. 2005 Jun;63(3):235-54 [15751025] Cell. 2005 Jun 3;121(5):795-807 [15935765] J Neurosci. 2006 Jan 11;26(2):479-89 [16407545] Nature. 2006 Jun 8;441(7094):757-60 [16760980] Curr Biol. 2006 Sep 5;16(17):1741-7 [16950113] Nature. 2007 Jan 11;445(7124):168-76 [17151600] Mol Cell Neurosci. 2007 Jun;35(2):383-96 [17498969] Nature. 2007 Nov 15;450(7168):420-4 [17943086] Nat Neurosci. 2008 May;11(5):538-40 [18391943] Neuron. 2008 Jul 31;59(2):322-35 [18667159] PLoS Biol. 2008 Nov 4;6(11):e273 [18986214] Nat Neurosci. 2009 Mar;12(3):356-62 [19219037] Curr Biol. 2009 Apr 14;19(7):613-9 [19303299] Adv Genet. 2009;65:79-143 [19615532] Front Mol Neurosci. 2009;2:11 [19738923] Front Mol Neurosci. 2009;2:12 [19753326] Science. 1995 Feb 10;267(5199):902-5 [7846534] Development. 1993 Jun;118(2):401-15 [8223268] Genetics. 1999 Mar;151(3):1093-101 [10049925] J Neurobiol. 2001 May;47(2):81-92 [11291099] Neuron. 2001 Sep 13;31(5):699-711 [11567611] Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12596-601 [11675495] Curr Biol. 2001 Dec 11;11(24):R1041-53 [11747845] Adv Genet. 2002;47:1-47 [12000095] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13232-7 [12239352] J Neurosci. 2002 Nov 1;22(21):9490-501 [12417673] J Neurogenet. 2002 Oct-Dec;16(4):205-28 [12745632] Trends Genet. 2004 Aug;20(8):384-91 [15262411] Nature. 2004 Oct 14;431(7010):854-9 [15372051] Cell. 2005 Apr 8;121(1):141-52 [15820685] Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12483-8 [16116081] J Neurosci. 2006 Jan 11;26(2):573-84 [16407556] Nature. 2006 Jun 8;441(7094):753-6 [16760979] J Comp Neurol. 2006 Sep 10;498(2):194-203 [16856137] J Neurosci. 2006 Oct 11;26(41):10380-6 [17035522] Neuron. 2006 Nov 9;52(3):425-36 [17088209] Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5199-204 [17360325] Nature. 2007 Jul 12;448(7150):151-6 [17625558] Curr Opin Neurobiol. 2007 Oct;17(5):572-80 [18024005] Neuron. 2008 Mar 13;57(5):634-60 [18341986] Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9715-20 [18621688] Neuron. 2008 Oct 23;60(2):328-42 [18957224] Neuron. 2008 Nov 26;60(4):672-82 [19038223] Neuron. 2009 Feb 12;61(3):373-84 [19217375] J Neurosci. 2009 Mar 18;29(11):3343-53 [19295141] Science. 2009 May 22;324(5930):1080-4 [19389999] Nature. 2009 Jun 4;459(7247):698-702 [19396159] Nature. 2009 Sep 17;461(7262):407-10 [19759620] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3389/neuro.02.020.2009 ER - TY - JOUR T1 - Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA). AN - 734130413; 19897081 AB - (+/-)-3,4-Methylenedioxymethamphetamine (MDMA) is a commonly abused illicit drug which affects multiple organ systems. In animals, high-dose administration of MDMA produces deficits in serotonin (5-HT) neurons (e.g., depletion of forebrain 5-HT) that have been viewed as neurotoxicity. Recent data implicate MDMA in the development of valvular heart disease (VHD). The present paper reviews several issues related to MDMA-associated neural and cardiac toxicities. The hypothesis of MDMA neurotoxicity in rats is evaluated in terms of the effects of MDMA on monoamine neurons, the use of scaling methods to extrapolate MDMA doses across species, and functional consequences of MDMA exposure. A potential treatment regimen (l-5-hydroxytryptophan plus carbidopa) for MDMA-associated neural deficits is discussed. The pathogenesis of MDMA-associated VHD is reviewed with specific reference to the role of valvular 5-HT(2B) receptors. We conclude that pharmacological effects of MDMA occur at the same doses in rats and humans. High doses of MDMA that produce 5-HT depletions in rats are associated with tolerance and impaired 5-HT release. Doses of MDMA that fail to deplete 5-HT in rats can cause persistent behavioral dysfunction, suggesting even moderate doses may pose risks. Finally, the MDMA metabolite, 3,4-methylenedioxyamphetamine (MDA), is a potent 5-HT(2B) agonist which could contribute to the increased risk of VHD observed in heavy MDMA users. JF - International review of neurobiology AU - Baumann, Michael H AU - Rothman, Richard B AD - Clinical Psychopharmacology Section, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, Maryland 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 257 EP - 296 VL - 88 SN - 0074-7742, 0074-7742 KW - Serotonin Agents KW - 0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Rats KW - Animals KW - Neurons -- drug effects KW - Humans KW - Neurotoxicity Syndromes -- physiopathology KW - Heart Valve Diseases -- chemically induced KW - Brain -- drug effects KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Heart -- drug effects KW - Serotonin Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734130413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Neural+and+cardiac+toxicities+associated+with+3%2C4-methylenedioxymethamphetamine+%28MDMA%29.&rft.au=Baumann%2C+Michael+H%3BRothman%2C+Richard+B&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988010-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-08 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Neurosci. 1990 Jul;13(7):290-6 [1695406] Ann N Y Acad Sci. 1990;600:649-61; discussion 661-4 [1979216] Neuropharmacology. 1990 Nov;29(11):1099-101 [1982341] Annu Rev Pharmacol Toxicol. 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Oct;1025:465-71 [15542750] Neurotox Res. 2004;6(7-8):589-614 [15639791] Br J Pharmacol. 2005 Jan;144(2):231-41 [15665862] J Psychopharmacol. 2005 Jan;19(1):71-83 [15671132] Neuropsychopharmacology. 2005 Mar;30(3):550-60 [15496938] J Exp Biol. 2005 May;208(Pt 9):1611-9 [15855392] Drug Alcohol Depend. 2006 Jan 4;81(1):27-36 [15975736] Neuropsychopharmacology. 2006 Feb;31(2):339-50 [15999148] Synapse. 2006 Apr;59(5):277-89 [16416445] J Psychopharmacol. 2006 Mar;20(2):211-25 [16510479] Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):377-87 [16863450] Curr Top Med Chem. 2006;6(17):1845-59 [17017961] Psychopharmacology (Berl). 2007 Jan;189(4):407-24 [16541247] N Engl J Med. 2007 Jan 4;356(1):6-9 [17202450] Pharmacol Biochem Behav. 2007 Apr;86(4):622-30 [17363047] Neuroscience. 2007 Aug 10;148(1):212-20 [17629409] Am J Cardiol. 2007 Nov 1;100(9):1442-5 [17950805] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0074-7742(09)88010-0 ER - TY - JOUR T1 - Acute methamphetamine intoxication: brain hyperthermia, blood-brain barrier, brain edema, and morphological cell abnormalities. AN - 734130085; 19897075 AB - Methamphetamine (METH) is a powerful and often abused stimulant with potent addictive and neurotoxic properties. While it is generally assumed that multiple chemical substances released in the brain following METH-induced metabolic activation (or oxidative stress) are primary factors underlying damage of neural cells, in this work we present data suggesting a role of brain hyperthermia and associated leakage of the blood-brain barrier (BBB) in acute METH-induced toxicity. First, we show that METH induces a dose-dependent brain and body hyperthermia, which is strongly potentiated by associated physiological activation and in warm environments that prevent proper heat dissipation to the external environment. Second, we demonstrate that acute METH intoxication induces robust, widespread but structure-specific leakage of the BBB, acute glial activation, and increased water content (edema), which are related to drug-induced brain hyperthermia. Third, we document widespread morphological abnormalities of brain cells, including neurons, glia, epithelial, and endothelial cells developing rapidly during acute METH intoxication. These structural abnormalities are tightly related to the extent of brain hyperthermia, leakage of the BBB, and brain edema. While it is unclear whether these rapidly developed morphological abnormalities are reversible, this study demonstrates that METH induces multiple functional and structural perturbations in the brain, determining its acute toxicity and possibly contributing to neurotoxicity. JF - International review of neurobiology AU - Kiyatkin, Eugene A AU - Sharma, Hari S AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 65 EP - 100 VL - 88 SN - 0074-7742, 0074-7742 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Fever -- chemically induced KW - Animals KW - Neuroglia -- pathology KW - Neurons -- drug effects KW - Humans KW - Poisoning KW - Neuroglia -- drug effects KW - Neurons -- pathology KW - Blood-Brain Barrier -- drug effects KW - Brain Edema -- chemically induced KW - Brain -- drug effects KW - Methamphetamine -- poisoning KW - Central Nervous System Stimulants -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734130085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Acute+methamphetamine+intoxication%3A+brain+hyperthermia%2C+blood-brain+barrier%2C+brain+edema%2C+and+morphological+cell+abnormalities.&rft.au=Kiyatkin%2C+Eugene+A%3BSharma%2C+Hari+S&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988004-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-08 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Hyperthermia. 2000 Jan-Feb;16(1):73-83 [10669318] J Chem Neuroanat. 2009 Jan;37(1):18-32 [18773954] Eur J Pharmacol. 2000 Dec 15;409(3):265-71 [11108820] Brain Res. 2001 Jan 5;888(1):117-127 [11146058] Glia. 2001 Apr 15;34(2):134-42 [11307162] Brain Res. 2001 Jun 29;905(1-2):21-5 [11423075] CMAJ. 2001 Oct 2;165(7):917-28 [11599334] J Appl Physiol (1985). 2002 Jun;92(6):2667-79 [12015388] Di Yi Jun Yi Da Xue Xue Bao. 2003 Jan;23(1):21-4 [12527507] Environ Res. 2003 May;92(1):48-53 [12706754] J Neurosci. 2003 May 1;23(9):3924-9 [12736362] Int J Hyperthermia. 2003 May-Jun;19(3):252-66 [12745971] Int J Hyperthermia. 2003 May-Jun;19(3):325-54 [12745974] Spinal Cord. 2003 Jul;41(7):369-78 [12815368] Neurobiol Aging. 2003 May-Jun;24 Suppl 1:S123-7; discussion S131 [12829120] Neurochem Res. 2003 Aug;28(8):1163-73 [12834255] Eur J Neurosci. 2004 Jul;20(1):51-8 [15245478] Neuroradiology. 2004 Jul;46(7):565-70 [15258709] Can Med Assoc J. 1975 Feb 8;112(3):299-304 [1089034] Experientia. 1975 Dec 15;31(12):1436-7 [1213067] J Neurosurg. 1977 Oct;47(4):525-31 [903805] Brain Res. 1980 Jul 7;193(1):153-63 [7378814] Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(7):1016-20 [4041105] J Neurol Sci. 1986 Jan;72(1):61-76 [2936871] Alcohol Drug Res. 1987;7(3):123-34 [2881551] Am J Physiol. 1988 Feb;254(2 Pt 2):H286-91 [3344819] Brain Res. 1989 May 1;486(1):73-8 [2720435] Neuropharmacology. 1989 Oct;28(10):1145-50 [2554183] Brain Res Dev Brain Res. 1990 Oct 1;56(1):47-53 [2279331] Radiat Res. 1991 Apr;126(1):43-51 [1850533] Neuroscience. 1992 Jun;48(4):889-901 [1630627] Neurochem Res. 1992 Sep;17(9):877-85 [1407275] Pharmacol Biochem Behav. 1993 Jan;44(1):87-98 [8094252] Ann N Y Acad Sci. 1993 May 28;679:195-210 [8512183] J Pharmacol Exp Ther. 1994 Aug;270(2):741-51 [8071867] J Pharmacol Exp Ther. 1994 Aug;270(2):752-60 [8071868] Synapse. 1994 Jul;17(3):203-9 [7974204] Brain Res. 1994 Sep 26;658(1-2):33-8 [7530580] J Pharmacol Exp Ther. 1995 Feb;272(2):868-75 [7853205] J Pharmacol Exp Ther. 1995 Dec;275(3):1104-14 [8531070] NIDA Res Monogr. 1996;163:251-76 [8809863] Ann N Y Acad Sci. 1997 Mar 15;813:572-80 [9100936] Hum Cell. 1996 Dec;9(4):353-66 [9183669] Prog Brain Res. 1998;115:241-74 [9632939] J Pharmacol Exp Ther. 1998 Oct;287(1):107-14 [9765328] Eur J Pharmacol. 1998 Dec 18;363(2-3):107-12 [9881575] Jpn J Pharmacol. 1963 Dec;13:230-9 [14097554] Physiol Behav. 2004 Dec 15;83(3):467-74 [15581669] Curr Pharm Des. 2005;11(11):1353-89 [15853669] Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1689-94 [15650123] Brain Res Brain Res Rev. 2005 Dec 1;50(1):27-56 [15890410] AAPS J. 2006;8(2):E413-8 [16808044] Pain. 2006 Sep;124(1-2):211-21 [16806707] Synapse. 2006 Dec 1;60(7):521-32 [16952162] Ann N Y Acad Sci. 2006 Aug;1074:198-224 [17105918] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] Prog Brain Res. 2007;162:173-99 [17645920] Eur J Neurosci. 2007 Sep;26(5):1242-53 [17767502] Neuron. 2008 Jan 24;57(2):178-201 [18215617] Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1240-6 [10801293] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0074-7742(09)88004-5 ER - TY - JOUR T1 - Teratogenicity and hyperprolactinemia. AN - 734041764; 19742198 JF - Indian journal of psychiatry AU - Andrade, Chittaranjan AD - Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 62 EP - 64 VL - 51 IS - 1 SN - 0019-5545, 0019-5545 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734041764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+psychiatry&rft.atitle=Teratogenicity+and+hyperprolactinemia.&rft.au=Andrade%2C+Chittaranjan&rft.aulast=Andrade&rft.aufirst=Chittaranjan&rft.date=2009-01-01&rft.volume=51&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+psychiatry&rft.issn=00195545&rft_id=info:doi/10.4103%2F0019-5545.44909 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2009-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epilepsia. 2008 Dec;49(12):2122-4 [18557775] J Clin Psychiatry. 2002;63 Suppl 4:56-62 [11913677] Neurology. 2008 Jul 22;71(4):272-6 [18645165] Reprod Toxicol. 2008 Apr;25(3):388-9 [18424066] J Psychopharmacol. 2008 Mar;22(2 Suppl):70-5 [18477623] CNS Drugs. 2008;22(4):325-34 [18336060] J Clin Psychopharmacol. 2007 Dec;27(6):639-61 [18004132] Am J Psychiatry. 2007 Sep;164(9):1404-10 [17728426] Eur J Neurol. 2006 Jun;13(6):645-54 [16796590] J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):193-8 [16157661] Neurology. 2005 Mar 22;64(6):961-5 [15781808] Neurology. 2005 Mar 22;64(6):955-60 [15781807] Neurology. 2005 Mar 22;64(6):949-54 [15781806] J Clin Endocrinol Metab. 1977 May;44(5):989-93 [558225] Am J Psychiatry. 2004 Apr;161(4):608-20 [15056503] J Clin Psychiatry. 2008 May;69(5):817-29 [18466043] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4103/0019-5545.44909 ER - TY - JOUR T1 - Fetal alcohol spectrum disorders: when science, medicine, public policy, and laws collide. AN - 734038859; 19731390 AB - Historically, alcohol has been used for different purposes including as a part of religious observances, as a food, at times as a medicine and its well-known use as a beverage. Until relatively recently these purposes have not changed and have at times been at odds with one another, resulting in collisions among policies and practices in science, medicine, public policy and the law. One area in which this has been particularly true is that of fetal alcohol spectrum disorders (FASD) where the adverse consequences of consumed alcohol on children in the womb and after birth may have been observed since antiquity, but the actions taken based on such observations have been influenced as much by the socio/cultural/political context of the times in which they were made as by evidence of harm. This article provides an overview of the inherent confusion when new scientific findings confront prevailing medical practice, the history involved in this confusion with respect to FASD, including public policy and legal issues that have arisen around alcohol and pregnancy, and the research and clinical challenges still being faced. (c) 2009 Wiley-Liss, Inc. JF - Developmental disabilities research reviews AU - Warren, Kenneth R AU - Hewitt, Brenda G AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 170 EP - 175 VL - 15 IS - 3 KW - Index Medicus KW - United States KW - Infant KW - History, 21st Century KW - History, 20th Century KW - Humans KW - History, 18th Century KW - Infant, Newborn KW - History, 19th Century KW - Female KW - Pregnancy KW - Alcoholism -- history KW - Public Policy -- history KW - Fetal Alcohol Spectrum Disorders -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734038859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+disabilities+research+reviews&rft.atitle=Fetal+alcohol+spectrum+disorders%3A+when+science%2C+medicine%2C+public+policy%2C+and+laws+collide.&rft.au=Warren%2C+Kenneth+R%3BHewitt%2C+Brenda+G&rft.aulast=Warren&rft.aufirst=Kenneth&rft.date=2009-01-01&rft.volume=15&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Developmental+disabilities+research+reviews&rft.issn=1940-5529&rft_id=info:doi/10.1002%2Fddrr.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2009-09-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ddrr.71 ER - TY - JOUR T1 - Recombinant immunotoxins for the treatment of chemoresistant hematologic malignancies. AN - 733970328; 19689336 AB - Recombinant immunotoxins are proteins composed of fragments of monoclonal antibodies fused to truncated protein toxins. No agents of this class are approved yet for medical use, although a related molecule, denileukin diftitox, composed of interleukin-2 fused to truncated diphtheria toxin, is approved for relapsed/refractory cutaneous T-cell lymphoma. Recombinant immunotoxins which have been tested in patients with chemotherapy-pretreated hematologic malignancies include LMB-2 (anti-CD25), BL22 (CAT-3888, anti-CD22) and HA22 (CAT-8015, anti-CD22), each containing an Fv fragment fused to truncated Pseudomonas exotoxin. Major responses were observed with LMB-2 in adult T-cell leukemia, chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma, Hodgkin's disease, and hairy cell leukemia (HCL). BL22 resulted in a high complete remission rate in patients with HCL, particularly those without excessive tumor burden. HA22, an improved version of BL22 with higher affinity to CD22, is now undergoing phase I testing in HCL, CLL, non-Hodgkin's lymphoma, and pediatric acute lymphoblastic leukemia. JF - Current pharmaceutical design AU - Kreitman, Robert J AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, 37/5124b, 9000 Rockville Pike, Bethesda, MD 20892, USA. kreitmar@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 2652 EP - 2664 VL - 15 IS - 23 KW - Diphtheria Toxin KW - 0 KW - Immunotoxins KW - Leukocidins KW - Pseudomonas aeruginosa Cytotoxins KW - Recombinant Proteins KW - Toxins, Biological KW - Index Medicus KW - Leukocidins -- pharmacology KW - Humans KW - Toxins, Biological -- pharmacology KW - Diphtheria Toxin -- pharmacology KW - Clinical Trials as Topic KW - Models, Biological KW - Recombinant Proteins -- biosynthesis KW - Hematologic Neoplasms -- drug therapy KW - Immunotoxins -- therapeutic use KW - Drug Resistance, Neoplasm -- immunology KW - Recombinant Proteins -- therapeutic use KW - Drug Discovery -- methods KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733970328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+design&rft.atitle=Recombinant+immunotoxins+for+the+treatment+of+chemoresistant+hematologic+malignancies.&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=15&rft.issue=23&rft.spage=2652&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+design&rft.issn=1873-4286&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-21 N1 - Date created - 2009-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amphetamine recapitulates developmental programs in the zebrafish. AN - 733943056; 19664194 AB - Addictive drugs hijack the human brain's 'reward' systems. A zebrafish model of addiction has recently been used to query changes in gene expression during this process. JF - Genome biology AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse/IRP, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA. jcadet@intra.nida.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 231 VL - 10 IS - 7 KW - Central Nervous System Stimulants KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Animals KW - Reward KW - Central Nervous System Stimulants -- toxicity KW - Signal Transduction -- drug effects KW - Conditioning, Classical -- drug effects KW - Models, Biological KW - Behavior, Addictive -- genetics KW - Transcription, Genetic -- drug effects KW - Amphetamine -- toxicity KW - Transcription, Genetic -- genetics KW - Zebrafish -- physiology KW - Zebrafish -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733943056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+biology&rft.atitle=Amphetamine+recapitulates+developmental+programs+in+the+zebrafish.&rft.au=Cadet%2C+Jean+Lud&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2009-01-01&rft.volume=10&rft.issue=7&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Genome+biology&rft.issn=1474-760X&rft_id=info:doi/10.1186%2Fgb-2009-10-7-231 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-13 N1 - Date created - 2009-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Brain Behav. 2004 Apr;3(2):63-74 [15005714] Neuropharmacology. 2004;47 Suppl 1:33-46 [15464124] Nature. 1981 May 28;291(5813):293-6 [7248006] Prog Neurobiol. 1994 Dec;44(5):497-516 [7886237] Development. 1996 Dec;123:1-36 [9007226] Can J Psychol. 1957 Jun;11(2):104-12 [13426853] Addict Biol. 2005 Mar;10(1):101-18 [15849024] Lab Anim (NY). 2006 May;35(5):33-9 [16645614] Methods. 2006 Jul;39(3):262-74 [16809048] Addict Biol. 2007 Sep;12(3-4):227-462 [17678505] J Clin Invest. 2008 Feb;118(2):454-61 [18246196] Genes Brain Behav. 2008 Mar;7(2):193-202 [17640290] Biochim Biophys Acta. 2008 Aug;1779(8):432-7 [18674649] Neuropharmacology. 2009;56 Suppl 1:73-82 [18647613] Biol Lett. 2009 Feb 23;5(1):112-6 [18755655] Brain Res Rev. 2009 Mar;59(2):253-77 [18762212] Neuron. 2009 May 14;62(3):335-48 [19447090] Genome Biol. 2009;10(7):R81 [19646228] Comment On: Genome Biol. 2009;10(7):R81 [19646228] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/gb-2009-10-7-231 ER - TY - JOUR T1 - Vascular endothelial barrier dysfunction mediated by amyloid-beta proteins. AN - 733867900; 19542618 AB - Neuronal inflammation is very common in Alzheimer's disease (AD). This inflammation can be caused by infiltration of neutrophils across the blood brain barrier. Endothelial permeability changes are required for the infiltration of high molecular weight components to the brain. Deposition of toxic amyloid-beta (A beta) fibrils in the cerebral vasculature, as well as in brain neurons, has been implicated in the development of AD. This study investigates the effect of A beta fibrils on the permeability of the endothelium and the mechanism for the observed permeability changes. A beta(1-40) and A beta(1-42) fibrils, but not monomers, were found to increase permeability of bovine pulmonary arterial endothelial cells in a dose- and time dependent manner as detected by transendothelial electrical resistance. This increase in permeability is only partially (25%) inhibited by catalase and is not associated with an increase in cytosolic Ca+2 or tyrosine phosphorylation. These results indicate that hydrogen peroxide is not the primary mediator for the permeability changes. Treatment of cells with both amyloid fibrils resulted in stress fiber formation, disruption and aggregation of actin filaments, and cellular gap formation. The results of this study reveal that A beta increases the permeability of endothelium by inducing change in the cytoskeleton network. JF - Journal of Alzheimer's disease : JAD AU - Nagababu, Enika AU - Usatyuk, Peter V AU - Enika, Divya AU - Natarajan, Viswanathan AU - Rifkind, Joseph M AD - Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 845 EP - 854 VL - 17 IS - 4 KW - Amyloid beta-Peptides KW - 0 KW - Cytoskeletal Proteins KW - Organophosphates KW - Polymers KW - tyrosine polyphosphate KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Microscopy, Fluorescence KW - Calcium -- metabolism KW - Animals KW - Cattle KW - Blotting, Western KW - Organophosphates -- metabolism KW - Cells, Cultured KW - Electric Impedance KW - Polymers -- metabolism KW - Pulmonary Artery -- cytology KW - Cytoskeletal Proteins -- metabolism KW - Time Factors KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- cytology KW - Amyloid beta-Peptides -- metabolism KW - Cell Membrane Permeability -- drug effects KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733867900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.atitle=Vascular+endothelial+barrier+dysfunction+mediated+by+amyloid-beta+proteins.&rft.au=Nagababu%2C+Enika%3BUsatyuk%2C+Peter+V%3BEnika%2C+Divya%3BNatarajan%2C+Viswanathan%3BRifkind%2C+Joseph+M&rft.aulast=Nagababu&rft.aufirst=Enika&rft.date=2009-01-01&rft.volume=17&rft.issue=4&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.issn=1875-8908&rft_id=info:doi/10.3233%2FJAD-2009-1104 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-22 N1 - Date created - 2010-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2007 May 23;27(21):5719-29 [17522316] Curr Alzheimer Res. 2007 Apr;4(2):191-7 [17430246] J Neurochem. 2008 Jan;104(2):500-13 [17953673] Brain Pathol. 2008 Apr;18(2):253-66 [18363936] Ann N Y Acad Sci. 2008 Mar;1123:134-45 [18375586] Neurobiol Aging. 2000 May-Jun;21(3):383-421 [10858586] J Struct Biol. 2000 Jun;130(2-3):184-208 [10940225] Am J Physiol Cell Physiol. 2000 Dec;279(6):C1772-81 [11078691] Am J Physiol Cell Physiol. 2001 Apr;280(4):C719-41 [11245588] J Cereb Blood Flow Metab. 2001 Jun;21(6):702-10 [11488539] Microcirculation. 2001 Aug;8(4):207-20 [11528529] J Appl Physiol (1985). 2001 Oct;91(4):1487-500 [11568129] Am J Physiol Cell Physiol. 2001 Dec;281(6):C1940-7 [11698252] Stroke. 2002 Apr;33(4):1152-62 [11935076] Free Radic Biol Med. 2002 Jun 1;32(11):1050-60 [12031889] J Neural Transm (Vienna). 2002 May;109(5-6):813-36 [12111471] Am J Physiol Cell Physiol. 2002 Sep;283(3):C895-904 [12176746] Surgery. 2002 Aug;132(2):180-5 [12219009] Acta Histochem. 2003;105(2):115-25 [12831163] Brain Res Brain Res Rev. 2003 Oct;43(2):207-23 [14572915] Antioxid Redox Signal. 2003 Dec;5(6):723-30 [14588145] J Alzheimers Dis. 2003 Aug;5(4):275-86 [14624023] Endothelium. 2003;10(6):309-17 [14741846] Microcirculation. 2003 Dec;10(6):463-70 [14745459] J Biol Chem. 2004 Mar 19;279(12):11789-97 [14699126] Int J Biochem Cell Biol. 2005 Feb;37(2):289-305 [15474976] Nature. 1987 Feb 19-25;325(6106):733-6 [2881207] Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7919-23 [1518814] Nature. 1992 Sep 24;359(6393):325-7 [1406936] Cell. 1994 Jun 17;77(6):817-27 [8004671] Neuron. 1996 May;16(5):921-32 [8630250] Neurosci Lett. 1996 Mar 15;206(2-3):157-60 [8710175] Am J Physiol. 1996 Jun;270(6 Pt 1):L973-8 [8764222] Nat Med. 1996 Aug;2(8):864-70 [8705854] Acta Neuropathol. 1996;91(1):6-14 [8773140] Am J Physiol. 1996 Feb;270(2 Pt 1):G363-9 [8779980] Life Sci. 1996;59(18):1483-97 [8890929] J Neurosci Res. 1997 Jan 15;47(2):216-23 [9008152] Free Radic Biol Med. 1997;23(1):134-47 [9165306] Am J Physiol. 1997 Jul;273(1 Pt 1):L31-9 [9252537] Am J Physiol. 1997 Jul;273(1 Pt 1):L172-84 [9252554] Ann N Y Acad Sci. 1997 Sep 26;826:161-72 [9329688] Neurosci Lett. 1998 Sep 4;253(2):139-41 [9774169] Am J Physiol. 1999 Jul;277(1 Pt 1):L150-8 [10409242] J Neurosci. 2005 Feb 2;25(5):1149-58 [15689551] Am J Pathol. 2005 Apr;166(4):955-7 [15793276] Int J Mol Med. 2005 Jun;15(6):929-35 [15870895] Cardiovasc Res. 2005 Oct 1;68(1):26-36 [16009356] Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L999-1010 [16040628] FASEB J. 2006 Mar;20(3):426-33 [16507760] Biochim Biophys Acta. 2007 Aug;1768(8):1976-90 [17433250] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3233/JAD-2009-1104 ER - TY - JOUR T1 - Truncation of histone H2A's C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects. AN - 733576900; 19667409 AB - Nickel(II), capable of transforming cells and causing tumors in humans and animals, has been previously shown by us to mediate hydrolytic truncation of histone H2A's C-terminal tail by 8 amino acids in both cell-free and cell culture systems. Since H2A's C-tail is involved in maintaining chromatin structure, such truncation might alter this structure and affect gene expression. To test the latter possibility, we transfected cultured T-REx 293 human embryonic kidney cells with plasmids expressing either wild type (wt) or truncated (q) histone H2A proteins, which were either untagged or N-terminally tagged with fluorescent proteins. Each histone variant was found to be incorporated into chromatin at 24 and 48 hr post-transfection. Cells transfected with the untagged plasmids were tested for gene expression by microarray and real-time PCR. Evaluation of the results for over 21,000 genes using the multidimensional scaling and hierarchical clustering methods revealed significant differences in expression of numerous genes between the q-H2A and wt-H2A transfectants. Many of the differentially expressed genes, including BAZ2A, CLDN18, CYP51A1, GFR, GIPC2, HMGB1, IRF7, JAK3, PSIP1, and VEGF, are cancer-related genes. The results thus demonstrate the potential of q-H2A to contribute to the process of carcinogenesis through epigenetic mechanisms. JF - Annals of clinical and laboratory science AU - Karaczyn, Aldona A AU - Cheng, Robert Y S AU - Buzard, Gregory S AU - Hartley, James AU - Esposito, Dominic AU - Kasprzak, Kazimierz S AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 251 EP - 262 VL - 39 IS - 3 KW - Histones KW - 0 KW - Recombinant Fusion Proteins KW - Nickel KW - 7OV03QG267 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Up-Regulation -- genetics KW - Amino Acid Sequence KW - Hydrolysis KW - Recombinant Fusion Proteins -- metabolism KW - Gene Expression Profiling KW - Polymerase Chain Reaction KW - Down-Regulation -- genetics KW - Transfection KW - Recombinant Fusion Proteins -- genetics KW - Time Factors KW - Cluster Analysis KW - Cell Line KW - Neoplasms -- etiology KW - Histones -- metabolism KW - Histones -- chemistry KW - Nickel -- metabolism KW - Gene Expression Regulation KW - Histones -- genetics KW - Sequence Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733576900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+and+laboratory+science&rft.atitle=Truncation+of+histone+H2A%27s+C-terminal+tail%2C+as+is+typical+for+Ni%28II%29-assisted+specific+peptide+bond+hydrolysis%2C+has+gene+expression+altering+effects.&rft.au=Karaczyn%2C+Aldona+A%3BCheng%2C+Robert+Y+S%3BBuzard%2C+Gregory+S%3BHartley%2C+James%3BEsposito%2C+Dominic%3BKasprzak%2C+Kazimierz+S&rft.aulast=Karaczyn&rft.aufirst=Aldona&rft.date=2009-01-01&rft.volume=39&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+and+laboratory+science&rft.issn=1550-8080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 1999 May 19;258(3):592-5 [10329430] Br J Haematol. 2006 May;133(3):270-5 [16643428] Biochim Biophys Acta. 2006 Apr;1765(2):148-54 [16386852] Int J Hematol. 2006 Apr;83(3):195-200 [16720547] Expert Rev Mol Med. 2006;8(18):1-11 [16887048] BMC Cancer. 2006;6:186 [16836752] Leukemia. 2006 Oct;20(10):1759-66 [16932349] Int J Biochem Cell Biol. 2007;39(1):171-80 [16979371] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16236-41 [17060627] Mol Cell Biol. 2007 Apr;27(7):2661-75 [17283066] Cancer Res. 2007 Mar 15;67(6):2559-67 [17363574] Cancer Sci. 2007 Jan;98(1):77-82 [17083565] Am J Surg Pathol. 2008 Feb;32(2):188-96 [18223320] Oncogene. 2008 Feb 28;27(10):1404-11 [17828303] Oncogene. 2008 Mar 6;27(11):1511-9 [17873904] Arch Med Res. 2008 May;39(4):365-72 [18375246] Acta Biochim Biophys Sin (Shanghai). 2008 Apr;40(4):297-303 [18401527] Breast J. 2008 May-Jun;14(3):261-7 [18373644] Curr Cancer Drug Targets. 2008 Jun;8(4):253-65 [18537549] J Histochem Cytochem. 2008 Aug;56(8):711-21 [18474937] Mol Med. 2008 Jul-Aug;14(7-8):476-84 [18431461] Cancer Biol Ther. 2008 Jul;7(7):1098-103 [18443431] Biochim Biophys Acta. 2008 Dec;1786(2):178-87 [18541156] Genes Chromosomes Cancer. 1999 Sep;26(1):62-9 [10441007] Cell. 1999 Aug 6;98(3):285-94 [10458604] J Virol. 2004 Dec;78(23):12987-95 [15542650] Front Biosci. 2005 Jan 1;10:866-72 [15569624] Clin Cancer Res. 2005 Jan 1;11(1):226-31 [15671550] Genes Dev. 2005 Feb 1;19(3):295-310 [15687254] Environ Health Perspect. 2005 May;113(5):577-84 [15866766] Clin Cancer Res. 2005 May 15;11(10):3758-65 [15897573] Immunology. 2005 Jul;115(3):358-65 [15946253] J Clin Invest. 2005 Jul;115(7):1765-76 [15965503] Clin Cancer Res. 2005 Oct 15;11(20):7369-75 [16243809] Clin Cancer Res. 2006 Jan 15;12(2):353-60 [16428472] J Pathol. 2006 Apr;208(5):633-42 [16435283] J Hum Genet. 2006;51(4):368-74 [16435073] Genomics. 2000 Jan 1;63(1):40-5 [10662543] Cancer Res. 2000 Mar 15;60(6):1521-5 [10749116] Hum Mol Genet. 2000 Mar 22;9(5):757-63 [10749982] Chem Res Toxicol. 2000 Jul;13(7):616-24 [10898594] Nucleic Acids Res. 2000 Sep 15;28(18):3478-85 [10982866] J Biol Chem. 2000 Nov 10;275(45):34901-8 [10934204] Genome Res. 2000 Nov;10(11):1788-95 [11076863] Radiat Res. 2001 Jan;155(1 Pt 2):181-187 [11121232] Genomics. 2001 Apr 15;73(2):211-22 [11318611] J Biol Chem. 2001 May 25;276(21):18624-32 [11278666] J Biol Chem. 2001 Feb 16;276(7):5074-84 [11085978] Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6599-604 [11381129] Biochem Biophys Res Commun. 2001 Jun 22;284(4):1083-9 [11409905] Biochim Biophys Acta. 2001 Dec 3;1522(2):118-21 [11750063] J Neural Transm Suppl. 2001;(61):95-107 [11771764] Biochem Cell Biol. 2001;79(6):693-708 [11800010] Int J Oncol. 2002 Mar;20(3):571-6 [11836570] J Interferon Cytokine Res. 2002 Jan;22(1):95-101 [11846980] Biochemistry. 2002 May 14;41(19):5945-9 [11993987] Int J Mol Med. 2002 Jun;9(6):585-9 [12011974] Int J Oncol. 2002 Jun;20(6):1183-7 [12011997] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7877-82 [12060735] Biochim Biophys Acta. 2002 Nov 4;1600(1-2):68-73 [12445461] Biochemistry. 2002 Dec 17;41(50):14960-8 [12475245] Mol Carcinog. 2002 Dec;35(4):186-95 [12489110] Am J Pathol. 2003 Jul;163(1):81-9 [12819013] Cancer Metastasis Rev. 2003 Dec;22(4):423-34 [12884916] Toxicol Appl Pharmacol. 2003 Aug 15;191(1):22-39 [12915101] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13225-30 [14578449] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13118-20 [14597707] Brain Res Mol Brain Res. 2003 Nov 26;119(2):216-9 [14625090] Genes Dev. 2003 Nov 15;17(22):2733-40 [14630937] J Cancer Res Clin Oncol. 2003 Dec;129(12):735-6 [14574570] Mutat Res. 2003 Dec 10;533(1-2):67-97 [14643413] Chem Res Toxicol. 2003 Dec;16(12):1555-9 [14680369] J Neurosci. 2004 Feb 18;24(7):1707-18 [14973233] Int J Oncol. 2004 Apr;24(4):1033-8 [15010845] J Invest Dermatol. 2004 May;122(5):1180-7 [15140221] Int J Oncol. 2004 Oct;25(4):821-30 [15375529] Biochim Biophys Acta. 1968 Aug 27;167(1):154-60 [4176710] Biochemistry. 1974 Dec 3;13(25):5128-34 [4373030] Cell. 1976 Dec;9(4 PT 2):785-92 [13934] Eur J Biochem. 1980 Aug;109(1):17-23 [7408874] Nucleic Acids Res. 1983 May 11;11(9):2681-700 [6406983] Ann Clin Lab Sci. 1984 Sep-Oct;14(5):355-65 [6236739] J Biol Chem. 1988 Dec 15;263(35):18972-8 [3058692] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6845-9 [8041707] Exp Cell Res. 1994 Nov;215(1):63-7 [7957682] Int J Cancer. 1998 Jun 10;76(6):903-8 [9626360] Chem Res Toxicol. 1998 Sep;11(9):1014-23 [9760275] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evolving views of DNA replication (in)fidelity. AN - 733372920; 19903750 AB - "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material" (Watson and Crick 1953). In the years since this remarkable understatement, we have come to realize the enormous complexity of the cellular machinery devoted to replicating DNA with the accuracy needed to maintain genetic information over many generations, balanced by the emergence of mutations on which selection can act. This complexity is partly based on the need to remove or tolerate cytotoxic and mutagenic lesions in DNA generated by environmental stress. Considered here is the fidelity with which undamaged and damaged DNA is replicated by the many DNA polymerases now known to exist. Some of these seriously violate Watson-Crick base-pairing rules such that, depending on the polymerase, the composition and location of the error, and the ability to correct errors (or not), DNA synthesis error rates can vary by more than a millionfold. This offers the potential to modulate rates of point mutations over a wide range, with consequences that can be either deleterious or beneficial. JF - Cold Spring Harbor symposia on quantitative biology AU - Kunkel, T A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. kunkel@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 91 EP - 101 VL - 74 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Escherichia coli -- metabolism KW - DNA Repair KW - Models, Molecular KW - Humans KW - Escherichia coli -- genetics KW - Models, Biological KW - DNA-Directed DNA Polymerase -- chemistry KW - INDEL Mutation KW - DNA Mismatch Repair KW - Genomic Instability KW - Mutation KW - DNA-Directed DNA Polymerase -- genetics KW - Protein Conformation KW - DNA-Directed DNA Polymerase -- metabolism KW - DNA Replication -- genetics KW - DNA Replication -- physiology KW - Evolution, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733372920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.atitle=Evolving+views+of+DNA+replication+%28in%29fidelity.&rft.au=Kunkel%2C+T+A&rft.aulast=Kunkel&rft.aufirst=T&rft.date=2009-01-01&rft.volume=74&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.issn=1943-4456&rft_id=info:doi/10.1101%2Fsqb.2009.74.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-12 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2002 Aug 1;16(15):1872-83 [12154119] Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7160-4 [1831267] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] Biochimie. 1975;57(5):587-95 [1182215] J Mol Biol. 1982 Mar 25;156(1):37-51 [6212689] Annu Rev Biochem. 1982;51:429-57 [6214209] Nature. 1985 Feb 28-Mar 6;313(6005):762-6 [3883192] Mol Gen Genet. 1994 Feb;242(3):289-96 [8107676] J Biol Chem. 1995 Jan 13;270(2):746-50 [7822305] Genetics. 1994 Nov;138(3):553-64 [7851754] Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10144-9 [9294177] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5 [9618505] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10020-5 [9707593] Ann N Y Acad Sci. 1999 May 18;870:100-7 [10415476] Nature. 1953 Apr 25;171(4356):737-8 [13054692] Biochim Biophys Acta. 1956 Jul;21(1):197-8 [13363894] Adv Protein Chem. 2004;69:229-64 [15588845] DNA Repair (Amst). 2003 Feb 3;2(2):135-49 [12531385] Curr Biol. 2003 Apr 29;13(9):744-8 [12725731] Structure. 2003 May;11(5):489-96 [12737815] Cold Spring Harb Symp Quant Biol. 2000;65:81-91 [12760023] Nat Genet. 2003 Jul;34(3):326-9 [12796780] Sci Aging Knowledge Environ. 2003 Feb 26;2003(8):RE3 [12844548] J Biol Chem. 2003 Oct 31;278(44):43770-80 [12882968] Mol Cell Biol. 2005 Jan;25(1):461-71 [15601866] Trends Immunol. 2005 Apr;26(4):215-20 [15797512] Mol Cell. 2005 May 27;18(5):499-505 [15916957] Annu Rev Biochem. 2005;74:681-710 [15952900] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15803-8 [16249340] Curr Biol. 2006 Jan 24;16(2):202-7 [16431373] Chem Rev. 2006 Feb;106(2):302-23 [16464007] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] Cell Cycle. 2006 May;5(9):958-62 [16687920] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18083-8 [17114294] Nat Struct Mol Biol. 2007 Jan;14(1):45-53 [17159995] Science. 2007 Jul 6;317(5834):127-30 [17615360] Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15591-8 [17898175] DNA Repair (Amst). 2007 Dec 1;6(12):1829-38 [17715002] Mol Cell. 2007 Nov 30;28(4):522-9 [18042449] Cell Res. 2008 Jan;18(1):148-61 [18166979] Mol Cell. 2008 Apr 25;30(2):137-44 [18439893] Mech Ageing Dev. 2008 Jul-Aug;129(7-8):391-407 [18406444] Nat Rev Genet. 2008 Aug;9(8):594-604 [18626473] J Mol Biol. 2008 Oct 17;382(4):859-69 [18691598] Trends Cell Biol. 2008 Nov;18(11):521-7 [18824354] Nat Chem Biol. 2009 Feb;5(2):82-90 [19148176] J Biol Chem. 2009 Feb 13;284(7):4041-5 [18835809] Nucleic Acids Res. 2009 Jun;37(11):3774-87 [19380376] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13910-3 [10570172] Annu Rev Biochem. 2000;69:497-529 [10966467] Mol Cell Biol. 2001 Feb;21(3):940-51 [11154280] Science. 2001 Mar 16;291(5511):2156-9 [11251121] Nat Med. 2001 Jun;7(6):638-9 [11385474] Cell. 2001 Jun 1;105(5):657-67 [11389835] Mol Cell. 2001 Jul;8(1):7-8 [11515498] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] Annu Rev Biochem. 2002;71:191-219 [12045095] EMBO J. 1989 Nov;8(11):3511-6 [2555167] Biochemistry. 1991 Jan 15;30(2):538-46 [1988042] DNA Repair (Amst). 2002 Jun 21;1(6):425-35 [12509231] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1101/sqb.2009.74.027 ER - TY - JOUR T1 - The development of gene therapy: from monogenic recessive disorders to complex diseases such as cancer. AN - 67439445; 19565894 AB - During the last 4 decades, gene therapy has moved from preclinical to clinical studies for many diseases ranging from monogenic recessive disorders such as hemophilia to more complex diseases such as cancer, cardiovascular disorders, and human immunodeficiency virus (HIV). To date, more than 1,340 gene therapy clinical trials have been completed, are ongoing, or have been approved in 28 countries, using more than 100 genes. Most of those clinical trials (66.5%) were aimed at the treatment of cancer. Early hype, failures, and tragic events have now largely been replaced by the necessary stepwise progress needed to realize clinical benefits. We now understand better the strengths and weaknesses of various gene transfer vectors; this facilitates the choice of appropriate vectors for individual diseases. Continuous advances in our understanding of tumor biology have allowed the development of elegant, more efficient, and less toxic treatment strategies. In this introductory chapter, we review the history of gene therapy since the early 1960s and present in detail two major recurring themes in gene therapy: (1) the development of vector and delivery systems and (2) the design of strategies to fight or cure particular diseases. The field of cancer gene therapy experienced an "awkward adolescence." Although this field has certainly not yet reached maturity, it still holds the potential of alleviating the suffering of many individuals with cancer. JF - Methods in molecular biology (Clifton, N.J.) AU - Gillet, Jean-Pierre AU - Macadangdang, Benjamin AU - Fathke, Robert L AU - Gottesman, Michael M AU - Kimchi-Sarfaty, Chava AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 5 EP - 54 VL - 542 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - History, 21st Century KW - History, 20th Century KW - Gene Transfer Techniques KW - Humans KW - Genetic Vectors KW - Genetic Therapy -- history KW - Neoplasms -- therapy KW - Neoplasms -- genetics KW - Genes, Recessive UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67439445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=The+development+of+gene+therapy%3A+from+monogenic+recessive+disorders+to+complex+diseases+such+as+cancer.&rft.au=Gillet%2C+Jean-Pierre%3BMacadangdang%2C+Benjamin%3BFathke%2C+Robert+L%3BGottesman%2C+Michael+M%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Gillet&rft.aufirst=Jean-Pierre&rft.date=2009-01-01&rft.volume=542&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-561-9_1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-561-9_1 ER - TY - JOUR T1 - Airway inflammation and upregulation of beta2 Mac-1 integrin expression on circulating leukocytes of female ragpickers in India. AN - 67390912; 19372628 AB - Over one million ragpickers collect and sale recyclable materials from municipal solid wastes (MSW) in India for a living. Since MSW contains a host of pathogenic microorganisms, we investigated the occurrence of airway inflammation and its underlying mechanism in 52 non-smoking female ragpickers (median age 29 yr) and 42 control women matched for age, smoking habit and socioeconomic conditions in Kolkata, eastern India. Spontaneously expectorated sputum were stained using the Papanicolau method for cytology, and flow cytometry was used for measurements of surface expression of beta(2) Mac-1 integrin (CD11b/CD18) on leukocytes and P-selectin on platelets. The concentrations of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and chemokine interleukin-8 (IL-8) were measured in plasma by enzyme-linked immunosorbent assay. Compared with controls, sputum samples of ragpickers contained significantly increased numbers of alveolar macrophages, neutrophils, eosinophils and lymphocytes, suggesting airway inflammation. Circulating neutrophils and monocytes of the ragpickers overexpressed CD11b/CD18 and their platelets had upregulated surface expression of P-selectin, implying functional activation of these cells. In addition, plasma levels of IL-8 and TNF-alpha were significantly increased, indicating greater trafficking of leukocytes from circulation to the tissues. Multivariate logistic regression analysis demonstrated a positive association between the ragpicking profession and leukocyte activation after controlling for potential confounders. Ragpickers experience leukocyte and platelet activation and airway inflammation that could make them more vulnerable to tissue damage and cardiovascular diseases. JF - Journal of occupational health AU - Ray, Manas Ranjan AU - Roychoudhury, Sanghita AU - Mukherjee, Sayali AU - Siddique, Shabana AU - Banerjee, Madhuchanda AU - Akolkar, A B AU - Sengupta, B AU - Lahiri, Twisha AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata, India. manasrray@rediffmail.com Y1 - 2009 PY - 2009 DA - 2009 SP - 232 EP - 238 VL - 51 IS - 3 KW - Macrophage-1 Antigen KW - 0 KW - P-Selectin KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Poverty KW - P-Selectin -- blood KW - Humans KW - Adult KW - Tumor Necrosis Factor-alpha -- blood KW - P-Selectin -- metabolism KW - Middle Aged KW - Garbage KW - Tumor Necrosis Factor-alpha -- metabolism KW - Female KW - India KW - Leukocytes -- metabolism KW - Macrophage-1 Antigen -- metabolism KW - Bronchitis -- etiology KW - Macrophage-1 Antigen -- blood KW - Bronchitis -- physiopathology KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67390912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+health&rft.atitle=Airway+inflammation+and+upregulation+of+beta2+Mac-1+integrin+expression+on+circulating+leukocytes+of+female+ragpickers+in+India.&rft.au=Ray%2C+Manas+Ranjan%3BRoychoudhury%2C+Sanghita%3BMukherjee%2C+Sayali%3BSiddique%2C+Shabana%3BBanerjee%2C+Madhuchanda%3BAkolkar%2C+A+B%3BSengupta%2C+B%3BLahiri%2C+Twisha&rft.aulast=Ray&rft.aufirst=Manas&rft.date=2009-01-01&rft.volume=51&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+health&rft.issn=1348-9585&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-22 N1 - Date created - 2009-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Rhinacanthus nasutus kurz on colon carcinogenesis in mice. AN - 67279193; 19469634 AB - Rhinacanthus nasutus Kurz, a Thai medicinal plant which possess antiproliferative and pro-apoptotic effects on human cancer cells, was examined for chemopreventive potential against colonic neoplasms induced by azoxymethane (AOM) combined with dextran sodium sulfate (DSS) in mice. Male ICR mice were given a single intraperitoneal administration of AOM (10 mg/kg body weight) followed by 2% DSS in their drinking water for a week. Water extract of the roots of R. nasutus (RNR) was given to the animals intragastrically daily in the initiation and promotion phases. The one hundred mice were divided into 8 groups, one group treated with AOM plus DSS serving as a control. Four other groups received AOM/DSS and RNR at 100 or 500 mg/kg body weight for 5 weeks (initiation phase study) and for 14 weeks (promotion phase study). Another two groups were given RNR alone at 100 and 500 mg/kg body weight and the last group was maintained untreated. At the end of the study, we found that the incidence and multiplicity of colonic tumors in mice fed with RNR both at 100 and 500 mg/kg body weight in initiation phase were higher than those in the control group. Moreover, RNR feeding during the promotion phase also gave similar results. Our results suggest that water extract of the roots of R. nasutus Kurz. has no preventive potential against colon carcinogenesis induced by AOM/DSS in mice, rather increasing the incidence of colonic tumors when given during initiation and promotion phases. Further study on RNR should provide more information on mechanisms of its tumor promotion activity. JF - Asian Pacific journal of cancer prevention : APJCP AU - Kupradinun, Piengchai AU - Siripong, Pongpun AU - Chanpai, Rittichai AU - Piyaviriyagul, Suratsawadee AU - Rungsipipat, Anudep AU - Wangnaitham, Supradit AD - National Cancer Institute, Bangkok, Thailand. pkupradi@health.moph.go.th PY - 2009 SP - 103 EP - 106 VL - 10 IS - 1 SN - 1513-7368, 1513-7368 KW - Carcinogens KW - 0 KW - Plant Extracts KW - Dextran Sulfate KW - 9042-14-2 KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Thailand KW - Mice KW - Male KW - Plant Extracts -- pharmacology KW - Plant Roots KW - Plants, Medicinal KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- chemically induced KW - Acanthaceae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67279193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Effects+of+Rhinacanthus+nasutus+kurz+on+colon+carcinogenesis+in+mice.&rft.au=Kupradinun%2C+Piengchai%3BSiripong%2C+Pongpun%3BChanpai%2C+Rittichai%3BPiyaviriyagul%2C+Suratsawadee%3BRungsipipat%2C+Anudep%3BWangnaitham%2C+Supradit&rft.aulast=Kupradinun&rft.aufirst=Piengchai&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.issn=1179-190X&rft_id=info:doi/10.2165%2F00063030-200923010-00001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-26 N1 - Date created - 2009-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neem (Azadirachta indica) leaf preparation prevents leukocyte apoptosis mediated by cisplatin plus 5-fluorouracil treatment in Swiss mice. AN - 67248675; 19346744 AB - Neem (Azadirachta indica) is widely regarded as a wonder tree because of its diverse medicinal applications. We investigated the ability of neem leaf preparation (NLP) to protect against apoptosis of circulating blood cells induced by cisplatin and 5-fluorouracil (cis + 5-FU) in carcinoma-bearing mice. Apoptosis was studied by annexin V-propidium iodide method. Total white blood cell count was performed using 3% glacial acetic acid on hemocytometer. Cytotoxicity was determined by LDH release assay and T/NK cell status was determined by flow cytometry. In comparison to untreated control, during cis + 5-FU therapy, significant down-regulation of leukocyte apoptosis was noted in mice pretreated with NLP or granulocyte colony stimulating factor (GCSF) during cis + 5-FU therapy. This enhanced cytotoxicity may be associated with NLP-induced increase of the cytotoxic T and NK cell pool. Efficacy of NLP is comparable to GCSF in its ability to protect against leukocyte apoptosis induced by cis + 5-FU. NLP would be a better choice of treatment because GCSF is tumor promoting, angiogenic and expensive. Copyright 2009 S. Karger AG, Basel. JF - Chemotherapy AU - Ghosh, Diptendu AU - Bose, Anamika AU - Haque, Enamul AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2009 PY - 2009 DA - 2009 SP - 137 EP - 144 VL - 55 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Plant Extracts KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Animals KW - Mice KW - Plant Leaves -- chemistry KW - Granulocyte Colony-Stimulating Factor -- pharmacology KW - Fluorouracil -- therapeutic use KW - Plant Extracts -- pharmacology KW - Cisplatin -- therapeutic use KW - Apoptosis KW - Fluorouracil -- toxicity KW - Leukocytes -- physiology KW - Cisplatin -- toxicity KW - Antineoplastic Agents -- toxicity KW - Azadirachta -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Leukocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67248675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemotherapy&rft.atitle=Neem+%28Azadirachta+indica%29+leaf+preparation+prevents+leukocyte+apoptosis+mediated+by+cisplatin+plus+5-fluorouracil+treatment+in+Swiss+mice.&rft.au=Tarca%2C+Adi+Laurentiu%3BDraghici%2C+Sorin%3BKhatri%2C+Purvesh%3BHassan%2C+Sonia+S%3BMittal%2C+Pooja%3BKim%2C+Jung-sun%3BKim%2C+Chong+Jai%3BKusanovic%2C+Juan+Pedro%3BRomero%2C+Roberto&rft.aulast=Tarca&rft.aufirst=Adi&rft.date=2009-01-01&rft.volume=25&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn577 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000211558 ER - TY - JOUR T1 - Epidemiologic studies in agricultural populations: observations and future directions. AN - 67244568; 19437268 AB - This paper reviews epidemiologic studies of cancer among agricultural populations to identify possible associations and to provide a focus for future investigations. Meta-analyses of mortality surveys of farmers find excesses of several cancers, including connective tissue, non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma and cancers of the skin, stomach, and brain, and deficits for total mortality, heart disease, total cancer, and cancers of the esophagus, colon, lung, and bladder. Meta-analyses of studies of individual cancers also support these findings, indicating a need to identify exposures and lifestyle factors that might account for this mortality pattern. Although cancer studies of other occupations that might have pesticide exposures in common with farmers show some similarities with observations among farmers, the overall patterns are quite different. This suggests that pesticides are not likely to fully explain the cancer and other disease patterns observed among farmers. Because exposures vary by type of farm operation, exposures for individual farmers can differ considerably. Studies in the future need to focus on the full range of exposures to fully understand the cancer pattern in farmers. JF - Journal of agromedicine AU - Blair, Aaron AU - Freeman, Laura Beane AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA. blaira@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 125 EP - 131 VL - 14 IS - 2 KW - Agrochemicals KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Occupational Exposure -- adverse effects KW - Meta-Analysis as Topic KW - Agrochemicals -- adverse effects KW - Agriculture KW - Agricultural Workers' Diseases -- etiology KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- epidemiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67244568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Epidemiologic+studies+in+agricultural+populations%3A+observations+and+future+directions.&rft.au=Blair%2C+Aaron%3BFreeman%2C+Laura+Beane&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2009-01-01&rft.volume=14&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1545-0813&rft_id=info:doi/10.1080%2F10599240902779436 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-24 N1 - Date created - 2009-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Scand J Work Environ Health. 1999 Oct;25(5):436-41 [10569464] J Expo Sci Environ Epidemiol. 2009 Sep;19(6):544-54 [19052531] Am J Ind Med. 2001 Nov;40(5):604-11 [11675631] Occup Environ Med. 2003 Sep;60(9):634-42 [12937183] Scand J Work Environ Health. 1992 Aug;18(4):209-15 [1411362] Int Arch Occup Environ Health. 1993;65(3):163-9 [8282414] Am J Ind Med. 1996 May;29(5):501-6 [8732923] Am J Ind Med. 1997 Nov;32(5):510-6 [9327075] Ann Epidemiol. 1998 Jan;8(1):64-74 [9465996] Am J Ind Med. 1998 Sep;34(3):252-60 [9698994] Scand J Work Environ Health. 1998 Aug;24(4):255-61 [9754856] Occup Environ Med. 1999 Jan;56(1):14-21 [10341741] Occup Environ Med. 1999 Aug;56(8):548-52 [10492653] Ann Epidemiol. 2005 Apr;15(4):279-85 [15780775] Am J Epidemiol. 2005 Jun 1;161(11):1037-46 [15901624] Cancer Causes Control. 2005 May;16(4):389-97 [15953981] Scand J Work Environ Health. 2005;31 Suppl 1:9-17; discussion 5-7 [16190144] Scand J Work Environ Health. 2005;31 Suppl 1:39-45; discussion 5-7 [16190148] Ann Occup Hyg. 2007 Jan;51(1):53-65 [16984946] Cancer Causes Control. 2007 Jun;18(5):457-78 [17443416] Am J Ind Med. 2001 Nov;40(5):596-603 [11675630] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10599240902779436 ER - TY - JOUR T1 - Treatment of adolescent depression: what we have come to know. AN - 67222436; 19404989 JF - Depression and anxiety AU - Vitiello, Benedetto AD - Child and Adolescent Treatment and Preventive Interventions Research Branch, National Institute of Mental Health, Room 7147, 6001 Executive Blvd., Bethesda 20892-9633, Maryland, USA. bvitiell@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 393 EP - 395 VL - 26 IS - 5 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Index Medicus KW - Cross-Sectional Studies KW - Randomized Controlled Trials as Topic KW - Suicide, Attempted -- statistics & numerical data KW - Combined Modality Therapy KW - Humans KW - Treatment Outcome KW - Adolescent KW - Fluoxetine -- adverse effects KW - Depressive Disorder, Major -- diagnosis KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Cognitive Therapy KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depressive Disorder, Major -- psychology KW - Fluoxetine -- therapeutic use KW - Depressive Disorder, Major -- therapy KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67222436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Treatment+of+adolescent+depression%3A+what+we+have+come+to+know.&rft.au=Vitiello%2C+Benedetto&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2009-01-01&rft.volume=26&rft.issue=5&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=1520-6394&rft_id=info:doi/10.1002%2Fda.20572 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-22 N1 - Date created - 2009-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/da.20572 ER - TY - JOUR T1 - United States National Library of Medicine Drug Information Portal. AN - 67147664; 19384716 AB - The Drug Information Portal is a free Web resource from the National Library of Medicine (NLM) that provides a user-friendly gateway to current information for more than 15,000 drugs. The site guides users to related resources of NLM, the National Institutes of Health (NIH), and other government agencies. Current drug-related information regarding consumer health, clinical trials, AIDS, MeSH pharmacological actions, MEDLINE/PubMed biomedical literature, and physical properties and structure is easily retrieved by searching on a drug name. A varied selection of focused topics in medicine and drugs is also available from displayed subject headings. This column provides background information about the Drug Information Portal, as well as search basics. JF - Medical reference services quarterly AU - Hochstein, Colette AU - Goshorn, Jeanne AU - Chang, Florence AD - Division of Specialized Information Services, National Library of Medicine, Bethesda, MD 20892, USA. colette@nlm.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 154 EP - 163 VL - 28 IS - 2 KW - Hazardous Substances KW - 0 KW - Pharmaceutical Preparations KW - Health administration KW - United States KW - Clinical Trials as Topic KW - National Library of Medicine (U.S.) KW - Databases, Factual KW - Information Storage and Retrieval -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67147664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+reference+services+quarterly&rft.atitle=United+States+National+Library+of+Medicine+Drug+Information+Portal.&rft.au=Hochstein%2C+Colette%3BGoshorn%2C+Jeanne%3BChang%2C+Florence&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2009-01-01&rft.volume=28&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Medical+reference+services+quarterly&rft.issn=1540-9597&rft_id=info:doi/10.1080%2F02763860902816784 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-28 N1 - Date created - 2009-04-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Med Ref Serv Q. 2006 Spring;25(1):37-48 [16635956] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/02763860902816784 ER - TY - JOUR T1 - What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus? AN - 67142003; 18608908 AB - Gliotoxin is a member of the epipolythiodioxopiperazine class of toxins and is both the major and the most potent toxin produced by Aspergillus fumigatus. Since the discovery of the putative gliotoxin biosynthetic 12-gene cluster in the genome of A. fumigatus, five different laboratories have attempted to determine the role of this toxin in the virulence of A. fumigatus. The genes in the cluster that have been disrupted to study the pathobiological importance of gliotoxin include gliZ that encodes a transcription factor and gliP that encodes a nonribosomal peptide synthase. Two of the five laboratories have reported gliotoxin to be an important virulence determinant of A. fumigatus, while the other three laboratories have shown it to be unimportant. Comparisons of the data generated among the five laboratories revealed that the immunosuppressive regimen used for mice was the key factor that contributed to the observed disparity. Regardless of either the mouse strains used or the route of infection, immunosuppression with a combination of cyclophosphamide and corticosteroids (neutropenic mice) showed gliotoxin to be unimportant. The mice immunosuppressed with corticosteroids alone, however, revealed that gliotoxin is an important virulence determinant of A. fumigatus. These studies indicate that the neutropenic mice model is inadequate to reveal the pathobiological importance of fungal secondary metabolites in invasive pulmonary aspergillosis. JF - Medical mycology AU - Kwon-Chung, Kyung J AU - Sugui, Janyce A AD - Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. june_kwon-chung@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S97 EP - 103 VL - 47 Suppl 1 KW - Virulence Factors KW - 0 KW - Gliotoxin KW - 67-99-2 KW - Index Medicus KW - Gene Knockout Techniques KW - Animals KW - Genes, Fungal KW - Multigene Family KW - Disease Models, Animal KW - Mice KW - Immunocompromised Host KW - Aspergillus fumigatus -- pathogenicity KW - Virulence Factors -- toxicity KW - Aspergillus fumigatus -- genetics KW - Virulence Factors -- genetics KW - Gliotoxin -- biosynthesis KW - Gliotoxin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67142003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Immunology&rft.atitle=Antibody-mediated+immunity+to+the+obligate+intracellular+bacterial+pathogen+Coxiella+burnetii+is+Fc+receptor-+and+complement-independent&rft.au=Shannon%2C+Jeffrey+G%3BCockrell%2C+Diane+C%3BTakahashi%2C+Kazue%3BStahl%2C+Gregory+L%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=10&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=BMC+Immunology&rft.issn=1471-2172&rft_id=info:doi/10.1186%2F1471-2172-10-26 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-27 N1 - Date created - 2009-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bone Marrow Transplant. 2002 Jan;29(1):15-9 [11840139] Microbiol Mol Biol Rev. 2002 Sep;66(3):447-59, table of contents [12208999] Blood. 2002 Dec 15;100(13):4358-66 [12393425] Bone Marrow Transplant. 2002 Dec;30(12):925-9 [12476286] Mycopathologia. 2003;156(2):133-8 [12733634] Infect Immun. 2004 Jun;72(6):3373-82 [15155643] Antimicrob Agents Chemother. 1972 Oct;2(4):261-6 [4670497] Proc Natl Acad Sci U S A. 1984 Jun;81(12):3835-7 [6203127] Int J Immunopharmacol. 1986;8(7):789-97 [2430903] J Biol Chem. 1988 Dec 5;263(34):18493-9 [2461370] Infect Immun. 1995 Sep;63(9):3266-71 [7543879] J Exp Med. 1996 Apr 1;183(4):1829-40 [8666939] Gen Pharmacol. 1996 Dec;27(8):1311-6 [9304400] Clin Infect Dis. 1999 Feb;28(2):322-30 [10064251] Clin Microbiol Rev. 1999 Apr;12(2):310-50 [10194462] J Bacteriol. 1999 Oct;181(20):6469-77 [10515939] Blood. 2005 Mar 15;105(6):2258-65 [15546954] Microbiology. 2005 Apr;151(Pt 4):1021-32 [15817772] Nat Rev Microbiol. 2005 Jun;3(6):470-8 [15931165] FEMS Microbiol Lett. 2005 Jul 15;248(2):241-8 [15979823] Eukaryot Cell. 2005 Sep;4(9):1574-82 [16151250] J Clin Microbiol. 2005 Dec;43(12):6120-2 [16333108] Acta Pharm. 2005 Dec;55(4):365-75 [16375826] Clin Immunol. 2006 Jan;118(1):108-16 [16213796] Eukaryot Cell. 2006 Jun;5(6):972-80 [16757745] J Cell Biol. 2006 Aug 14;174(4):509-19 [16893972] Mol Microbiol. 2006 Oct;62(1):292-302 [16956378] Infect Immun. 2006 Dec;74(12):6761-8 [17030582] Biochemistry. 2006 Dec 19;45(50):15029-38 [17154540] Biol Lett. 2007 Oct 22;3(5):523-5 [17686752] Eukaryot Cell. 2007 Sep;6(9):1562-9 [17601876] Eukaryot Cell. 2007 Sep;6(9):1552-61 [17630330] J Leukoc Biol. 2007 Oct;82(4):839-48 [17626149] BMC Evol Biol. 2007;7:174 [17897469] J Infect Dis. 2008 Feb 1;197(3):479-86 [18199036] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/13693780802056012 ER - TY - JOUR T1 - Colobronchial fistula: an unusual complication after peritonectomy and hyperthermic intra-peritoneal chemotherapy (HIPEC). AN - 67141389; 19368141 AB - Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an innovative approach to peritoneal carcinomatosis. Due to the complexity of the combined procedure, high rates of potentially life-threatening complications have been reported. This is the first report of colobronchial fistula following CRS and HIPEC. A 70-year-old woman underwent CRS and HIPEC for papillary well-differentiated peritoneal mesothelioma. During the postoperative course, recurrent pneumonia occurred and bacteria of intestinal origin were isolated from expectorated sputum. Water-soluble contrast studies revealed direct communication between the left colon flexure and the bronchial tree. After appropriate medical and supportive therapies, the patient underwent resection of the splenic flexure and immediate anastomosis with complete recovery. Colobronchial fistula is a rare and potentially lethal complication of CRS and HIPEC. A suggestive clinical picture and contrast studies allow conclusive diagnosis to be made. Surgery is a safe and effective therapeutic option. JF - In vivo (Athens, Greece) AU - Laterza, Barbara AU - Baratti, Dario AU - Cozzi, Guido AU - Kusamura, Shigeki AU - Oliva, Grazia Daniela AU - Gavazzi, Cecilia AU - Fumagalli, Luca AU - Sironi, Alessandro AU - Sabia, Domenico AU - Deraco, Marcello AD - Department of Surgery, National Cancer Institute, Milan, Italy. PY - 2009 SP - 151 EP - 153 VL - 23 IS - 1 SN - 0258-851X, 0258-851X KW - Index Medicus KW - Colon KW - Combined Modality Therapy KW - Peritoneum -- surgery KW - Humans KW - Treatment Outcome KW - Aged KW - Radiography KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Female KW - Mesothelioma -- therapy KW - Intestinal Fistula -- diagnostic imaging KW - Peritoneal Neoplasms -- pathology KW - Hyperthermia, Induced -- adverse effects KW - Mesothelioma -- pathology KW - Bronchial Fistula -- surgery KW - Postoperative Complications -- pathology KW - Postoperative Complications -- etiology KW - Intestinal Fistula -- surgery KW - Intestinal Fistula -- etiology KW - Bronchial Fistula -- etiology KW - Peritoneal Neoplasms -- therapy KW - Bronchial Fistula -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67141389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Colobronchial+fistula%3A+an+unusual+complication+after+peritonectomy+and+hyperthermic+intra-peritoneal+chemotherapy+%28HIPEC%29.&rft.au=Laterza%2C+Barbara%3BBaratti%2C+Dario%3BCozzi%2C+Guido%3BKusamura%2C+Shigeki%3BOliva%2C+Grazia+Daniela%3BGavazzi%2C+Cecilia%3BFumagalli%2C+Luca%3BSironi%2C+Alessandro%3BSabia%2C+Domenico%3BDeraco%2C+Marcello&rft.aulast=Laterza&rft.aufirst=Barbara&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies. AN - 67118532; 19344187 AB - Immunotoxins are molecules that contain a protein toxin and a ligand that is either an antibody or a growth factor. The ligand binds to a target cell antigen, and the target cell internalizes the immunotoxin, allowing the toxin to migrate to the cytoplasm where it can kill the cell. In the case of recombinant immunotoxins, the ligand and toxin are encoded in DNA that is then expressed in bacteria, and the purified immunotoxin contains the ligand and toxin fused together. Among the most active recombinant immunotoxins clinically tested are those that are targeted to hematologic malignancies. One agent, containing human interleukin-2 and truncated diphtheria toxin (denileukin diftitox), has been approved for use in cutaneous T-cell lymphoma, and has shown activity in other hematologic malignancies, including leukemias and lymphomas. Diphtheria toxin has also been targeted by other ligands, including granulocyte-macrophage colony-stimulating factor and interleukin-3, to target myelogenous leukemia cells. Single-chain antibodies containing variable heavy and light antibody domains have been fused to truncated Pseudomonas exotoxin to target lymphomas and lymphocytic leukemias. Recombinant immunotoxins anti-Tac(Fv)-PE38 (LMB-2), targeting CD25, and RFB4(dsFv)-PE38 (BL22, CAT-3888), targeting CD22, have each been tested in patients. Major responses have been observed after failure of standard chemotherapy. The most successful application of recombinant immunotoxins today is in hairy cell leukemia, where BL22 has induced complete remissions in most patients who were previously treated with optimal chemotherapy. JF - BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy AU - Kreitman, Robert J AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. kreitmar@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1 EP - 13 VL - 23 IS - 1 KW - Antibodies KW - 0 KW - Antibodies, Monoclonal KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Bacterial Toxins KW - Diphtheria Toxin KW - Enterotoxins KW - Exotoxins KW - Immunotoxins KW - Interleukin-2 KW - RFB4(dsFv)-PE38 recombinant immunotoxin KW - Recombinant Fusion Proteins KW - denileukin diftitox KW - 25E79B5CTM KW - Index Medicus KW - Animals KW - Antibodies -- therapeutic use KW - Interleukin-2 -- therapeutic use KW - Humans KW - Treatment Outcome KW - Enterotoxins -- therapeutic use KW - Diphtheria Toxin -- therapeutic use KW - Exotoxins -- therapeutic use KW - Recombinant Fusion Proteins -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use KW - Hematologic Neoplasms -- therapy KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- adverse effects KW - Immunotoxins -- adverse effects KW - Bacterial Toxins -- therapeutic use KW - Immunotoxins -- therapeutic use KW - Hematologic Neoplasms -- immunology KW - Immunotoxins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67118532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.atitle=Recombinant+immunotoxins+containing+truncated+bacterial+toxins+for+the+treatment+of+hematologic+malignancies.&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.issn=1179-190X&rft_id=info:doi/10.2165%2F00063030-200923010-00001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-04 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Jpn J Cancer Res. 1990 Sep;81(9):902-8 [2121691] J Biol Chem. 1990 Nov 25;265(33):20673-7 [2243114] Proc Natl Acad 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Lymphoma. 2002 Apr;43(4):885-8 [12153180] Leukemia. 2003 Jan;17(1):155-9 [12529673] Traffic. 2006 Apr;7(4):379-93 [16536737] Ann Intern Med. 1997 Jun 1;126(11):882-5 [9163289] Leuk Lymphoma. 1997 Apr;25(3-4):381-5 [9168448] Toxicol Lett. 1997 Apr 28;91(2):121-7 [9175848] Biochem Soc Trans. 1997 May;25(2):709-14 [9191188] Blood. 1997 Jul 1;90(1):252-9 [9207460] Eur J Immunol. 1997 Jun;27(6):1459-68 [9209499] Blood. 1997 Sep 1;90(5):2020-6 [9292538] J Biol Chem. 1997 Sep 26;272(39):24165-9 [9305866] Biochemistry. 1997 Nov 25;36(47):14577-82 [9398176] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2165/00063030-200923010-00001 ER - TY - JOUR T1 - Collection and preparation of rodent tissue samples for histopathological and molecular studies in carcinogenesis. AN - 67112480; 19347291 AB - Histology, as a mean of tissue visualization on a cellular level, is a fundamental tool in the study of cancer. The need for simultaneous delivery of quality histological material for pathological evaluation and subsequent genomic and proteomic studies, however, requires modification of traditional practices to include rapid isolation and stabilization of target tissue to preserve molecular integrity. Informative molecular analysis depends on the integrity of target molecules (RNA, DNA, and proteins) in the tissue during and after its collection. A reliable systematic approach to routine and genomic/proteomic sample collection and preparation presented is supported by detailed protocols. JF - Methods in molecular biology (Clifton, N.J.) AU - Golubeva, Yelena AU - Rogers, Keith AD - Histotechnology Laboratory, NCI-Frederick, SAIC-Frederick, Frederick, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 3 EP - 60 VL - 511 SN - 1064-3745, 1064-3745 KW - RNA, Neoplasm KW - 0 KW - Index Medicus KW - Biological Assay -- methods KW - Animals KW - Microdissection -- methods KW - Genomics -- methods KW - Microdissection -- instrumentation KW - Humans KW - RNA Stability KW - Biological Assay -- instrumentation KW - Mice KW - Lasers KW - RNA, Neoplasm -- analysis KW - Female KW - Histocytochemistry -- methods KW - Neoplasms -- pathology KW - Tissue Fixation -- methods KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67112480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Collection+and+preparation+of+rodent+tissue+samples+for+histopathological+and+molecular+studies+in+carcinogenesis.&rft.au=Golubeva%2C+Yelena%3BRogers%2C+Keith&rft.aulast=Golubeva&rft.aufirst=Yelena&rft.date=2009-01-01&rft.volume=511&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-447-6_1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-18 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-447-6_1 ER - TY - JOUR T1 - Automation in an addiction treatment research clinic: computerised contingency management, ecological momentary assessment and a protocol workflow system. AN - 67073985; 19320669 AB - A challenge in treatment research is the necessity of adhering to protocol and regulatory strictures while maintaining flexibility to meet patients' treatment needs and to accommodate variations among protocols. Another challenge is the acquisition of large amounts of data in an occasionally hectic environment, along with the provision of seamless methods for exporting, mining and querying the data. We have automated several major functions of our outpatient treatment research clinic for studies in drug abuse and dependence. Here we describe three such specialised applications: the Automated Contingency Management (ACM) system for the delivery of behavioural interventions, the transactional electronic diary (TED) system for the management of behavioural assessments and the Protocol Workflow System (PWS) for computerised workflow automation and guidance of each participant's daily clinic activities. These modules are integrated into our larger information system to enable data sharing in real time among authorised staff. ACM and the TED have each permitted us to conduct research that was not previously possible. In addition, the time to data analysis at the end of each study is substantially shorter. With the implementation of the PWS, we have been able to manage a research clinic with an 80 patient capacity, having an annual average of 18,000 patient visits and 7300 urine collections with a research staff of five. Finally, automated data management has considerably enhanced our ability to monitor and summarise participant safety data for research oversight. When developed in consultation with end users, automation in treatment research clinics can enable more efficient operations, better communication among staff and expansions in research methods. JF - Drug and alcohol review AU - Vahabzadeh, Massoud AU - Lin, Jia-Ling AU - Mezghanni, Mustapha AU - Epstein, David H AU - Preston, Kenzie L AD - Biomedical Informatics Section, Administrative Management Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, Maryland 21224, USA. massoudv@nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 3 EP - 11 VL - 28 IS - 1 KW - Index Medicus KW - Ambulatory Care -- organization & administration KW - Efficiency, Organizational KW - Humans KW - Decision Support Systems, Clinical KW - Communication KW - Automation -- methods KW - Behavior Therapy -- methods KW - Time Factors KW - Substance Abuse Detection -- methods KW - Research Design -- legislation & jurisprudence KW - Information Systems KW - Substance Abuse Treatment Centers -- organization & administration KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67073985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+review&rft.atitle=Automation+in+an+addiction+treatment+research+clinic%3A+computerised+contingency+management%2C+ecological+momentary+assessment+and+a+protocol+workflow+system.&rft.au=Vahabzadeh%2C+Massoud%3BLin%2C+Jia-Ling%3BMezghanni%2C+Mustapha%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Vahabzadeh&rft.aufirst=Massoud&rft.date=2009-01-01&rft.volume=28&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+review&rft.issn=1465-3362&rft_id=info:doi/10.1111%2Fj.1465-3362.2008.00007.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Consult Clin Psychol. 2007 Oct;75(5):765-74 [17907858] J Am Med Inform Assoc. 2007 Jul-Aug;14(4):415-23 [17460127] J Am Med Inform Assoc. 2007 May-Jun;14(3):387-8; discussion 389 [17329719] J Investig Med. 2006 May;54(4):171-3 [17152855] J Investig Med. 2006 Sep;54(6):327-33 [17134616] J Am Med Inform Assoc. 2006 Sep-Oct;13(5):547-56 [16799128] AMIA Annu Symp Proc. 2005;:455-9 [16779081] Arch Gen Psychiatry. 2006 Feb;63(2):201-8 [16461864] BMJ. 2005 Dec 3;331(7528):1313-6 [16269467] J Consult Clin Psychol. 2005 Apr;73(2):354-9 [15796645] J Nerv Ment Dis. 1987 Sep;175(9):526-36 [3655778] J Biomed Inform. 2003 Jun;36(3):218-27 [14615230] JAMA. 2003 Mar 12;289(10):1278-87 [12633190] J Am Med Inform Assoc. 2000 Mar-Apr;7(2):135-45 [10730596] Drug Alcohol Depend. 2000 Feb 1;58(1-2):9-25 [10669051] Health Policy. 2007 Dec;84(2-3):181-90 [17624470] J Appl Behav Anal. 2008 Winter;41(4):539-49 [19192858] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1465-3362.2008.00007.x ER - TY - JOUR T1 - PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells. AN - 67047488; 19305641 AB - Cytoplasmic expression of claudin-1 in metastatic melanoma cells correlates to increased migration, and increased secretion of MMP-2 in a PKC dependent manner, whereas claudin-1 nuclear expression is found in benign nevi. Melanoma cells were transfected with a vector expressing CLDN-1 fused to a nuclear localization signal (NLS). Despite significant nuclear localization of claudin-1, there was still transport of claudin-1 to the cytoplasm. Phorbol ester treatment of cells transfected with NLS-claudin-1 resulted in an exclusion of claudin-1 from the nucleus, despite the NLS. To ascertain whether PKC or PKA were involved in this translocation, we mutated the putative phosphorylation sites within the protein. We found that mutating the PKC phosphorylation sites to mimic a non-phosphorylated state did not cause a shift of claudin-1 to the nucleus of the cells, but mutating the PKA sites did. Mutations of either site to mimic constitutive phosphorylation resulted in cytoplasmic claudin-1 expression. Stable claudin-1 transfectants containing non-phosphorylatable PKA sites exhibited decreased motility. These data imply that subcellular localization of claudin-1 can be controlled by phosphorylation, dicating effects on metastatic capacity. JF - International journal of medical sciences AU - French, Amanda D AU - Fiori, Jennifer L AU - Camilli, Tura C AU - Leotlela, Poloko D AU - O'Connell, Michael P AU - Frank, Brittany P AU - Subaran, Sarah AU - Indig, Fred E AU - Taub, Dennis D AU - Weeraratna, Ashani T AD - Laboratory of Immunology, National Institute on Aging, Baltimore, MD 21124, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 93 EP - 101 VL - 6 IS - 2 KW - CLDN1 protein, human KW - 0 KW - Claudin-1 KW - Membrane Proteins KW - Nuclear Localization Signals KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - PKA KW - metastasis KW - Claudin KW - melanoma KW - PKC KW - Neoplasm Invasiveness KW - Computer Simulation KW - Cell Nucleus -- metabolism KW - Enzyme Activation KW - Humans KW - Biological Transport -- genetics KW - Cell Line, Tumor KW - Cell Nucleus -- drug effects KW - Nuclear Localization Signals -- metabolism KW - Matrix Metalloproteinase 2 -- metabolism KW - Mutagenesis, Site-Directed KW - Phosphorylation KW - Cytoplasm -- genetics KW - Transfection KW - Cytoplasm -- metabolism KW - Genetic Vectors KW - Neoplasm Metastasis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Subcellular Fractions -- metabolism KW - Nuclear Localization Signals -- genetics KW - Immunohistochemistry KW - Cell Nucleus -- genetics KW - Protein Kinase C -- metabolism KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Melanoma -- pathology KW - Membrane Proteins -- metabolism KW - Melanoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67047488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+medical+sciences&rft.atitle=PKC+and+PKA+phosphorylation+affect+the+subcellular+localization+of+claudin-1+in+melanoma+cells.&rft.au=French%2C+Amanda+D%3BFiori%2C+Jennifer+L%3BCamilli%2C+Tura+C%3BLeotlela%2C+Poloko+D%3BO%27Connell%2C+Michael+P%3BFrank%2C+Brittany+P%3BSubaran%2C+Sarah%3BIndig%2C+Fred+E%3BTaub%2C+Dennis+D%3BWeeraratna%2C+Ashani+T&rft.aulast=French&rft.aufirst=Amanda&rft.date=2009-01-01&rft.volume=6&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=International+journal+of+medical+sciences&rft.issn=1449-1907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2009-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroreport. 2000 May 15;11(7):1427-31 [10841351] Methods Mol Biol. 2008;468:243-53 [19099260] Traffic. 2001 Feb;2(2):93-8 [11247307] J Cell Biol. 2002 Mar 18;156(6):1099-111 [11889141] Oncol Res. 2001;12(11-12):469-76 [11939410] Cancer Cell. 2002 Apr;1(3):279-88 [12086864] J Biol Chem. 2003 Jan 24;278(4):2692-700 [12403786] Am J Physiol Cell Physiol. 2003 Aug;285(2):C300-9 [12660149] J Biol Chem. 2004 Aug 20;279(34):35702-8 [15187091] Am J Pathol. 2005 May;166(5):1541-54 [15855653] J Biol Chem. 2005 Jul 15;280(28):26233-40 [15905176] J Clin Invest. 2005 Jul;115(7):1765-76 [15965503] Cancer Res. 2005 Nov 1;65(21):9603-6 [16266975] Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H381-9 [16155104] Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):287-91 [16831296] Oncogene. 2007 May 31;26(26):3846-56 [17160014] J Biol Chem. 2007 Jun 8;282(23):17259-71 [17426020] Mol Pharmacol. 2008 Aug;74(2):432-42 [18477669] PLoS One. 2008;3(7):e2715 [18648642] Cancer Res. 2008 Dec 15;68(24):10205-14 [19074888] Cancer Res. 2000 Nov 15;60(22):6281-7 [11103784] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - EEG and cerebral blood flow velocity abnormalities in chronic cocaine users. AN - 67016958; 19278131 AB - EEG and cerebral blood flow abnormalities have been documented in chronic cocaine abusers. To identify possible relationships between EEG and blood flow changes and their relationship to the intensity of cocaine use, we recorded the resting eyes-closed EEG and anterior (ACA) and middle (MCA) cerebral artery blood flow velocity during systole (V(S)) and diastole (V(D)) by transcranial Doppler (TCD) sonography of 99 (76 male, 23 female; mean [SD] age 34.3 [5.2] years, 8.6 [5.5] years of cocaine use, 17.8 [7.7] days of cocaine use in month prior to screening) cocaine users within 5 days of admission to a closed research unit. Forty-two non-drug-using, age-matched control subjects (22 male, 20 female) were tested as outpatients. A 3-minute period of resting EEG was recorded from 16 standard scalp electrodes. Artifact-free EEG was converted to six frequency bands (delta, theta, alpha1, alpha2, beta1 and beta2) using a Fast Fourier Transform. Pulsatility index (PI) was calculated as a measure of small vessel resistance. Cocaine users had decreased VD and increased PI in the MCA, with no difference in V(S), and reduced EEG theta, beta1 and beta2 absolute power in posterior brain regions. Recent cocaine use was positively associated with MCA PI (r = 0.27, p < 0.001) and negatively associated with low frequency EEG power (delta power: r = -0.25, p < 0.002; theta power: r = -0.29, p < 0.001). EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence. JF - Clinical EEG and neuroscience AU - Copersino, Marc L AU - Herning, Ronald I AU - Better, Warren AU - Cadet, Jean-Lud AU - Gorelick, David A AD - Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 39 EP - 42 VL - 40 IS - 1 SN - 1550-0594, 1550-0594 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Analysis of Variance KW - Blood Flow Velocity KW - Humans KW - Adult KW - Ultrasonography, Doppler, Transcranial KW - Cocaine -- toxicity KW - Fourier Analysis KW - Male KW - Female KW - Anterior Cerebral Artery -- drug effects KW - Brain -- blood supply KW - Brain -- drug effects KW - Electroencephalography KW - Anterior Cerebral Artery -- diagnostic imaging KW - Cerebrovascular Circulation KW - Middle Cerebral Artery -- diagnostic imaging KW - Cocaine-Related Disorders -- diagnostic imaging KW - Brain -- physiopathology KW - Middle Cerebral Artery -- physiopathology KW - Middle Cerebral Artery -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Anterior Cerebral Artery -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67016958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+and+neuroscience&rft.atitle=EEG+and+cerebral+blood+flow+velocity+abnormalities+in+chronic+cocaine+users.&rft.au=Copersino%2C+Marc+L%3BHerning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean-Lud%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2009-01-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+and+neuroscience&rft.issn=15500594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-03 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addict Behav. 1994 Nov-Dec;19(6):599-607 [7701971] J Nucl Med. 1995 Jul;36(7):1211-5 [7790946] J Neurosurg. 1996 Jan;84(1):79-84 [8613840] Psychiatry Res. 1995 Oct 16;58(3):247-57 [8570780] Epilepsia. 1996 Sep;37(9):875-8 [8814101] Biol Psychiatry. 1996 Nov 15;40(10):986-93 [8915557] Neurology. 1997 Feb;48(2):341-5 [9040718] Biol Psychiatry. 1997 Jun 1;41(11):1087-94 [9146819] Drug Alcohol Depend. 1997 Jun 6;46(1-2):87-93 [9246556] Neuropsychopharmacology. 1998 Jul;19(1):1-9 [9608571] Biol Psychiatry. 1999 May 1;45(9):1203-11 [10331113] J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):209-21 [10333992] Neuropsychopharmacology. 1999 Jul;21(1):110-8 [10379525] J Clin Neurophysiol. 2004 Sep-Oct;21(5):341-52 [15592008] Arch Gen Psychiatry. 2007 Apr;64(4):495-502 [17404126] Postgrad Med J. 2007 Jun;83(980):389-94 [17551070] Clin Neurophysiol. 2000 Apr;111(4):604-12 [10727911] Stroke. 2000 May;31(5):1111-5 [10797173] Neuropsychobiology. 2000;42(2):93-8 [10940764] Clin Neurophysiol. 2000 Nov;111(11):1961-7 [11068230] Neuropsychopharmacology. 2001 Sep;25(3):332-40 [11522462] Stroke. 2001 Oct;32(10):2338-43 [11588323] Epilepsia. 2002;43 Suppl 2:28-31 [11903480] Biol Psychiatry. 2002 Oct 15;52(8):831-42 [12372655] J Psychoactive Drugs. 2002 Oct-Dec;34(4):415-9 [12562110] Stroke. 2003 Jun;34(6):1375-81 [12764233] Radiology. 1990 Sep;176(3):821-4 [2389042] Am J Drug Alcohol Abuse. 1990;16(3-4):307-17 [2126913] Headache. 1991 Jan;31(1):17-9 [2016163] J Nucl Med. 1991 Jun;32(6):1206-10 [2045934] Psychiatry Res. 1990 Dec;35(2):95-105 [2100807] J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):803-6 [1955899] J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):419-27 [8286941] J Nucl Med. 1994 Dec;35(12):1902-9 [7989967] Neuropsychobiology. 1994;30(4):189-96 [7862268] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Helicobacter Pylori associated global gastric cancer burden. AN - 67013314; 19273142 AB - Helicobacter pylori infection is ubiquitous, infecting close to one-half of the world's population, but its prevalence is declining in developed countries. Chronic H. pylori infection is etiologically linked to gastric adenocarcinoma, especially non-cardia type (63% of all stomach cancer or ~5.5% of the global cancer burden: ~25% of cancers associated with infectious etiology), and to gastric mucosal associated lymphoid tissue (MALT) lymphoma, which accounts for up to 8% of all non-Hodgkin lymphoma. Epidemiological, clinical, and animal studies have established a central role for H. pylori in gastric carcinogenesis and provided insights into the mechanisms and biologic relationships between bacterial infection, host genetics, nutrition, and environmental factors. These discoveries invite strategies to prevent infection to be the logical primary goals in a multi-pronged effort to curtail suffering and death from H. pylori infection-associated cancers. JF - Frontiers in bioscience (Landmark edition) AU - Mbulaiteye, Sam M AU - Hisada, Michie AU - El-Omar, Emad M AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. mbulaits@mail.nih.gov Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 1490 EP - 1504 VL - 14 KW - Index Medicus KW - Virulence KW - Global Health KW - Risk Factors KW - Humans KW - Incidence KW - Stomach Neoplasms -- microbiology KW - Lymphoma, B-Cell, Marginal Zone -- prevention & control KW - Lymphoma, B-Cell, Marginal Zone -- microbiology KW - Lymphoma, B-Cell, Marginal Zone -- epidemiology KW - Helicobacter pylori -- pathogenicity KW - Stomach Neoplasms -- prevention & control KW - Stomach Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67013314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%28Landmark+edition%29&rft.atitle=Helicobacter+Pylori+associated+global+gastric+cancer+burden.&rft.au=Mbulaiteye%2C+Sam+M%3BHisada%2C+Michie%3BEl-Omar%2C+Emad+M&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2009-01-01&rft.volume=14&rft.issue=&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%28Landmark+edition%29&rft.issn=1093-4715&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Scand J Gastroenterol. 1997 Jan;32(1):28-33 [9018763] Semin Gastrointest Dis. 1997 Jul;8(3):142-55 [9232727] Gastroenterology. 1998 Jun;114(6):1169-79 [9609753] J Infect Dis. 1998 Sep;178(3):717-21 [9728540] Pediatr Res. 1999 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Infect Immun. 2003 Jun;71(6):3496-502 [12761134] IARC Sci Publ. 2002;(155):1-781 [12812229] Cancer Sci. 2003 Mar;94(3):235-9 [12824915] Gastroenterology. 2003 Aug;125(2):364-71 [12891537] Gut. 2003 Dec;52(12):1684-9 [14633943] JAMA. 2004 Jan 14;291(2):187-94 [14722144] Gastroenterology. 2003 Dec;125(6):1636-44 [14724815] Curr Top Med Chem. 2004;4(5):531-8 [14965304] Helicobacter. 2004 Jun;9(3):262-70 [15165263] J Gastroenterol. 2004;39(5):429-33 [15175940] Gastroenterology. 2004 Jul;127(1):73-9 [15236174] Aliment Pharmacol Ther. 2004 Jul;20 Suppl 1:1-6 [15298598] Nat Rev Cancer. 2004 Sep;4(9):688-94 [15343275] Leukemia. 2004 Oct;18(10):1722-6 [15356642] J Infect Dis. 2004 Nov 1;190(9):1605-9 [15478065] Br Med J. 1965 Sep 25;2(5464):719-22 [4283943] East Afr Med J. 1966 Jul;43(7):274-83 [5911333] Lancet. 1984 Jun 16;1(8390):1311-5 [6145023] Med J Aust. 1985 Apr 15;142(8):439-44 [3982346] Epidemiol Rev. 1986;8:1-27 [3533579] Afr J Med Med Sci. 1988 Jun;17(2):89-95 [2843023] Cancer Res. 1990 Aug 1;50(15):4737-40 [2369748] Am J Gastroenterol. 1992 Jan;87(1):28-30 [1728121] Lancet. 1993 Sep 4;342(8871):575-7 [8102719] Gut. 1993 Dec;34(12):1672-6 [8282253] Gastroenterology. 1996 Aug;111(2):426-32 [8690208] Scand J Gastroenterol Suppl. 1996;220:23-6 [8898432] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine content and delivery across tobacco products. AN - 66873681; 19184646 AB - Nicotine is the principal alkaloid in both commercial and homemade products (e.g., cigarettes, smokeless tobacco, bidis, waterpipes) followed by nornicotine, anabasine, anatabine, and many other basic substances that contain a cyclic nitrogenous nucleus. Tobacco types, leaf position on the plant, agricultural practices, fertilizer treatment, and degree of ripening are among some prominent factors that determine the levels of alkaloids in tobacco leaf. From a random examination of 152 cultivated varieties of Nicotiana tabacum, a range of alkaloid variation between 0.17 and 4.93% was determined. In fact, every step in tobacco production that affects plant metabolism will influence the level of alkaloid content to a certain degree. Depending on blending recipe, type and amount of additives, and product design, all types of tobacco products contain a very wide range of nicotine concentration. However, the ultimate emission of nicotine to the user, exposure, and psychophar-macological effects depend not only on the content and emission, but also on the relationship between the product and the user. JF - Handbook of experimental pharmacology AU - Djordjevic, Mirjana V AU - Doran, Kelly A AD - Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd, EPN 4048, MSC 7337, Bethesda, MD 20892-7337, USA. djordjev@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 61 EP - 82 IS - 192 SN - 0171-2004, 0171-2004 KW - Alkaloids KW - 0 KW - Nicotinic Agonists KW - Tobacco Smoke Pollution KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Alkaloids -- chemistry KW - Humans KW - Smoking -- metabolism KW - Tobacco Smoke Pollution -- analysis KW - Tobacco, Smokeless -- chemistry KW - Plant Leaves -- chemistry KW - Tobacco -- chemistry KW - Nicotinic Agonists -- chemistry KW - Nicotine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66873681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Nicotine+content+and+delivery+across+tobacco+products.&rft.au=Djordjevic%2C+Mirjana+V%3BDoran%2C+Kelly+A&rft.aulast=Djordjevic&rft.aufirst=Mirjana&rft.date=2009-01-01&rft.volume=&rft.issue=192&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-69248-5_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-3-540-69248-5_3 ER - TY - JOUR T1 - Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. AN - 66850292; 19015200 AB - Androgens and estrogens may play a role in gastric cancer etiology. To investigate the association of gastric cancer with single-nucleotide polymorphisms (SNPs) in six genes (COMT, CYP1B1, CYP17A1, CYP19A1, HSD17B1 and SHBG) involved in estrogen and androgen synthesis and metabolism, 58 haplotype-tagging SNPs were genotyped in 295 gastric cancer cases and 415 controls from a population-based study in Poland. We assessed differences in haplotype frequency between cases and controls using a global score test and calculated multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for individual haplotypes using logistic regression. We found associations in one linkage disequilibrium (LD) block containing the 3' untranslated region of COMT (rs9332377, rs165728, rs165849 and rs1110478), global score test (df = 4, P = 0.033). Relative to the most frequent GATA haplotype, the GATG haplotype was associated with statistically significant increased gastric cancer risk (OR = 1.50, 95% CI: 1.06-2.12; false discovery rate (FDR) value = 0.459) and the AACA haplotype with borderline increased risk (OR = 1.36, 95% CI = 1.00-1.85; FDR = 0.50). We also found associations for the LD block containing part of the SHBG coding region (rs6258, rs6259, rs2955617, rs1641544 and rs1641537). The CACCC haplotype was associated with statistically significant lower gastric cancer risk relative to the referent CGACC haplotype (OR = 0.55, 95% CI = 0.34-0.90; FDR = 0.459), but the overall score test was statistically non-significant. No other statistically significant associations were observed. In summary, we found possible associations between gastric cancer and polymorphisms in COMT, involved in estrogen inactivation, and SHBG, a modulator of hormone bioavailability. These findings should be interpreted cautiously until replicated in other studies. JF - Carcinogenesis AU - Freedman, Neal D AU - Ahn, Jiyoung AU - Hou, Lifang AU - Lissowska, Jolanta AU - Zatonski, Witold AU - Yeager, Meredith AU - Chanock, Stephen J AU - Chow, Wong Ho AU - Abnet, Christian C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA. freedmanne@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 71 EP - 77 VL - 30 IS - 1 KW - Androgens KW - 0 KW - Estrogens KW - Index Medicus KW - Humans KW - Male KW - Female KW - Risk Assessment KW - Polymorphism, Single Nucleotide KW - Stomach Neoplasms -- metabolism KW - Estrogens -- metabolism KW - Stomach Neoplasms -- genetics KW - Androgens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66850292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+estrogen-+and+androgen-metabolizing+genes+and+the+risk+of+gastric+cancer.&rft.au=Freedman%2C+Neal+D%3BAhn%2C+Jiyoung%3BHou%2C+Lifang%3BLissowska%2C+Jolanta%3BZatonski%2C+Witold%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BChow%2C+Wong+Ho%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2009-01-01&rft.volume=69&rft.issue=1&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-2490 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1999 Jun 11;81(6):871-6 [10362132] Nat Rev Cancer. 2005 Dec;5(12):977-85 [16341085] Breast Cancer Res Treat. 1999 Mar;54(2):101-7 [10424400] Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2203-7 [15598781] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):329-35 [15734954] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Am J Hum Genet. 2005 May;76(5):887-93 [15789306] J Clin Endocrinol Metab. 2005 Apr;90(4):2198-204 [15634719] Eur J Cell Biol. 2005 Mar;84(2-3):205-14 [15819401] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1096-101 [15894658] Cancer Lett. 2005 Sep 28;227(2):115-24 [16112414] Cancer Causes Control. 2000 Oct;11(9):869-74 [11075877] Ann Oncol. 2000 Dec;11(12):1537-43 [11205460] Pharmacogenetics. 2001 Nov;11(8):655-61 [11692073] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Cancer Lett. 2002 Feb 25;176(2):129-35 [11804739] Int J Cancer. 2002 Feb 20;97(6):833-8 [11857364] Gastric Cancer. 2002;5(4):213-9 [12491079] Cancer Causes Control. 2003 Feb;14(1):53-9 [12708725] Pigment Cell Res. 2003 Jun;16(3):190-7 [12753385] Am J Hum Genet. 2003 Jul;73(1):152-61 [12802784] Hum Hered. 2003;55(1):56-65 [12890927] J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):477-86 [14623547] J Natl Cancer Inst. 2004 Jun 16;96(12):936-45 [15199113] Infect Immun. 2004 Sep;72(9):5181-92 [15322013] J Cancer Res Clin Oncol. 2004 May;130(5):253-8 [14963700] Am J Epidemiol. 2004 Oct 15;160(8):729-40 [15466495] Cancer Res. 1982 Dec;42(12):5181-2 [7139622] J Clin Endocrinol Metab. 1992 Oct;75(4):1066-70 [1400872] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Br J Cancer. 2006 Jan 16;94(1):136-41 [16404367] Cancer Res. 2006 Feb 15;66(4):2468-75 [16489054] PLoS Genet. 2005 Nov;1(5):e68 [16311626] Breast Cancer Res Treat. 2006 Sep;99(2):235-40 [16596327] Cancer Res. 2006 Oct 1;66(19):9781-5 [17018638] Ann Epidemiol. 2006 Dec;16(12):908-16 [16843679] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):165-8 [17220347] Cancer Res. 2007 Mar 1;67(5):1893-7 [17325027] Cancer. 2007 Apr 1;109(7):1296-302 [17315164] BMC Cancer. 2007;7:60 [17411440] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78 [17507624] Gut. 2007 Dec;56(12):1671-7 [17627962] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2237-46 [18006912] Carcinogenesis. 2007 Dec;28(12):2597-604 [17724378] Am J Gastroenterol. 2008 Jun;103(6):1476-87 [18510611] Protein Sci. 1992 Jul;1(7):902-9 [1304375] Int J Cancer. 1994 Mar 15;56(6):812-5 [8119771] Int J Cancer. 1994 Dec 15;59(6):761-4 [7989115] J Natl Cancer Inst. 1995 May 3;87(9):645-51 [7752269] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] J Clin Endocrinol Metab. 1998 Jan;83(1):235-40 [9435448] Carcinogenesis. 1998 Jan;19(1):1-27 [9472688] Am J Epidemiol. 1999 Apr 15;149(8):706-11 [10206619] Cell. 2005 Sep 9;122(5):751-62 [16143106] J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):481-5 [10419028] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn258 ER - TY - JOUR T1 - Base excision repair of oxidative DNA damage and association with cancer and aging. AN - 66848833; 18978338 AB - Aging has been associated with damage accumulation in the genome and with increased cancer incidence. Reactive oxygen species (ROS) are produced from endogenous sources, most notably the oxidative metabolism in the mitochondria, and from exogenous sources, such as ionizing radiation. ROS attack DNA readily, generating a variety of DNA lesions, such as oxidized bases and strand breaks. If not properly removed, DNA damage can be potentially devastating to normal cell physiology, leading to mutagenesis and/or cell death, especially in the case of cytotoxic lesions that block the progression of DNA/RNA polymerases. Damage-induced mutagenesis has been linked to various malignancies. The major mechanism that cells use to repair oxidative damage lesions, such as 8-hydroxyguanine, formamidopyrimidines, and 5-hydroxyuracil, is base excision repair (BER). The BER pathway in the nucleus is well elucidated. More recently, BER was shown to also exist in the mitochondria. Here, we review the association of BER of oxidative DNA damage with aging, cancer and other diseases. JF - Carcinogenesis AU - Maynard, Scott AU - Schurman, Shepherd H AU - Harboe, Charlotte AU - de Souza-Pinto, Nadja C AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 2 EP - 10 VL - 30 IS - 1 KW - Reactive Oxygen Species KW - 0 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Humans KW - Subcellular Fractions -- metabolism KW - Base Pairing KW - DNA Repair KW - DNA Damage KW - Oxidative Stress KW - Neoplasms -- genetics KW - Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66848833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Base+excision+repair+of+oxidative+DNA+damage+and+association+with+cancer+and+aging.&rft.au=Maynard%2C+Scott%3BSchurman%2C+Shepherd+H%3BHarboe%2C+Charlotte%3Bde+Souza-Pinto%2C+Nadja+C%3BBohr%2C+Vilhelm+A&rft.aulast=Maynard&rft.aufirst=Scott&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn250 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9 [9012815] Nucleic Acids Res. 1997 Feb 15;25(4):750-5 [9016624] Science. 2005 Jul 15;309(5733):481-4 [16020738] Cancer Epidemiol Biomarkers 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1990;77(5):501-2 [2400824] Cancer Res. 1991 Feb 1;51(3):794-8 [1846317] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn250 ER - TY - JOUR T1 - The role of toxicoproteomics in assessing organ specific toxicity. AN - 66838550; 19157068 AB - Aims of this chapter on the role of toxicoproteomics in assessing organ-specific toxicity are to define the field of toxicoproteomics, describe its development among global technologies, and show potential uses in experimental toxicological research, preclinical testing and mechanistic biological research. Disciplines within proteomics deployed in preclinical research are described as Tier I analysis, involving global protein mapping and protein profiling for differential expression, and Tier II proteomic analysis, including global methods for description of function, structure, interactions and post-translational modification of proteins. Proteomic platforms used in toxicoproteomics research are briefly reviewed. Preclinical toxicoproteomic studies with model liver and kidney toxicants are critically assessed for their contributions toward understanding pathophysiology and in biomarker discovery. Toxicoproteomics research conducted in other organs and tissues are briefly discussed as well. The final section suggests several key developments involving new approaches and research focus areas for the field of toxicoproteomics as a new tool for toxicological pathology. JF - EXS AU - Merrick, B Alex AU - Witzmann, Frank A AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, Durham, NC 27709, USA. merrick@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 367 EP - 400 VL - 99 SN - 1023-294X, 1023-294X KW - Index Medicus KW - Animals KW - Humans KW - Proteomics -- methods KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66838550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EXS&rft.atitle=The+role+of+toxicoproteomics+in+assessing+organ+specific+toxicity.&rft.au=Merrick%2C+B+Alex%3BWitzmann%2C+Frank+A&rft.aulast=Merrick&rft.aufirst=B&rft.date=2009-01-01&rft.volume=99&rft.issue=&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=EXS&rft.issn=1023294X&rft_id=info:doi/ LA 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Oct;37(2):225-34 [6814950] Toxicol Lett. 1989 Mar;46(1-3):125-39 [2650019] Toxicol Appl Pharmacol. 1990 May;103(3):463-73 [2339419] Clin Chem. 1994 Jul;40(7 Pt 2):1363-7 [8013120] Drug Metab Rev. 1995;27(1-2):147-77 [7641574] Electrophoresis. 1995 Jul;16(7):1273-83 [7498176] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae. AN - 66832769; 19153345 AB - Drug hypersensitivity syndrome (DHS) is a severe, multisystem adverse drug reaction that may occur following the use of numerous medications, including anticonvulsants, sulfonamides, and minocycline hydrochloride. Long-term autoimmune sequelae of DHS have been reported, including hypothyroidism. A 15-year-old female adolescent developed DHS 4 weeks after starting minocycline therapy for acne vulgaris. Seven weeks later she developed autoimmune hyperthyroidism (Graves disease), and 7 months after discontinuing minocycline therapy she developed autoimmune type 1 diabetes mellitus. In addition, she developed elevated titers of several markers of systemic autoimmune disease, including antinuclear, anti-Sjögren syndrome A, and anti-Smith antibodies. Minocycline-associated DHS may be associated with multiple autoimmune sequelae, including thyroid disease, type 1 diabetes mellitus, and elevated markers of systemic autoimmunity. Long-term follow-up is needed in patients with DHS to determine the natural history of DHS-associated sequelae. JF - Archives of dermatology AU - Brown, Rebecca J AU - Rother, Kristina I AU - Artman, Henry AU - Mercurio, Mary Gail AU - Wang, Roger AU - Looney, R John AU - Cowen, Edward W AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Rockville, Maryland, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 63 EP - 66 VL - 145 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Minocycline KW - FYY3R43WGO KW - Abridged Index Medicus KW - Index Medicus KW - Graves Disease -- chemically induced KW - Acne Vulgaris -- drug therapy KW - Humans KW - Diabetes Mellitus, Type 1 -- chemically induced KW - Adolescent KW - Female KW - Anti-Bacterial Agents -- therapeutic use KW - Drug Hypersensitivity -- etiology KW - Anti-Bacterial Agents -- adverse effects KW - Autoimmune Diseases -- chemically induced KW - Minocycline -- adverse effects KW - Minocycline -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66832769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Minocycline-induced+drug+hypersensitivity+syndrome+followed+by+multiple+autoimmune+sequelae.&rft.au=Brown%2C+Rebecca+J%3BRother%2C+Kristina+I%3BArtman%2C+Henry%3BMercurio%2C+Mary+Gail%3BWang%2C+Roger%3BLooney%2C+R+John%3BCowen%2C+Edward+W&rft.aulast=Brown&rft.aufirst=Rebecca&rft.date=2009-01-01&rft.volume=145&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=1538-3652&rft_id=info:doi/10.1001%2Farchdermatol.2008.521 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2009-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Pediatr. 1999 Oct;11(5):447-56 [10555598] Br J Dermatol. 2007 Sep;157(3):540-6 [17596147] Arch Intern Med. 2002 May 27;162(10):1190-2 [12020192] Diabetes Care. 2002 Dec;25(12):2302-7 [12453977] Arch Dermatol. 2004 Feb;140(2):183-8 [14967790] Arch Dermatol. 2004 Feb;140(2):226-30 [14967800] Diabet Med. 2004 Oct;21(10):1156-7 [15384968] J Invest Dermatol. 1986 Apr;86(4):449-53 [3755739] Clin Pharmacol Ther. 1992 Jan;51(1):56-67 [1732077] Biochem Pharmacol. 1992 Sep 25;44(6):1165-70 [1417938] Antimicrob Agents Chemother. 1996 Apr;40(4):934-40 [8849255] Diabetes. 1997 Jan;46(1):143-9 [8971095] Arthritis Rheum. 2004 Dec 15;51(6):1030-44 [15593352] Toxicology. 2005 Apr 15;209(2):165-7 [15767030] Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9 [15743917] J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S14-7 [16427984] Exp Clin Endocrinol Diabetes. 2006 Jan;114(1):35-8 [16450315] Clin Rheumatol. 2006 Mar;25(2):240-5 [16247581] Pharmacogenet Genomics. 2006 Apr;16(4):297-306 [16538176] Diabetes Care. 2006 May;29(5):1179-80 [16644665] Br J Dermatol. 2006 Aug;155(2):422-8 [16882184] Allergol Int. 2006 Mar;55(1):1-8 [17075280] Br J Dermatol. 2007 May;156(5):1005-9 [17408394] Pediatr Dermatol. 2007 May-Jun;24(3):246-9 [17542873] Curr Opin Allergy Clin Immunol. 2007 Aug;7(4):317-23 [17620823] JAMA. 2001 Mar 7;285(9):1153-4 [11231743] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archdermatol.2008.521 ER - TY - JOUR T1 - Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan. AN - 66830468; 18647964 AB - Screening of the oral cavity and dental care was suggested as mandatory preventive measures of osteonecrosis of the jaw (ONJ) in patients receiving bisphosphonates (BPs). We investigated the occurrence of ONJ before and after implementation of dental preventive measures when starting BP therapy. Since April 2005, 154 consecutive patients treated with BPs (POST-Group) have undergone a baseline mouth assessment (dental visit +/- orthopantomography of the jaws) to detect potential dental conditions and dental care if required. A retrospective review was also conducted of all consecutive cancer patients with bone metastases (PRE-Group) and treated for the first time with BPs from January 1999 to April 2005 in our clinic without receiving any preventive measure. Incidence proportion and incidence rate (IR) were used to estimate the incidence of ONJ. Among the study population (966 patients; male/female=179/787), 73% had breast cancer. 25% of patients were given zoledronic acid (ZOL), 62% pamidronate (PAM), 8% PAM followed by ZOL and 5% clodronate. ONJ was observed in 28 patients (2.9%); we observed a reduction in the incidence of ONJ from 3.2% to 1.3%, when comparing-pre and post-implementation of preventive measures programme. Considering the patients exposed to ZOL, the performance of a dental examination and the application of preventive measures led to a sustained reduction in ONJ IR (7.8% in the PRE-Group versus 1.7% in the POST-Group; P=0.016), with an IR ratio of 0.30 (95% confidence interval 0.03-1.26). ONJ is a manageable and preventable condition. Our data confirm that the application of preventive measures can significantly reduce the incidence of ONJ in cancer patients receiving BPs therapy. Dental exams combined to the identification of patients at risk in cooperation with the Dental Team can improve outcomes and increase the number of ONJ-free patients. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Ripamonti, C I AU - Maniezzo, M AU - Campa, T AU - Fagnoni, E AU - Brunelli, C AU - Saibene, G AU - Bareggi, C AU - Ascani, L AU - Cislaghi, E AD - Palliative Care Unit (Pain Therapy and Rehabilitation), IRCCS Foundation, National Cancer Institute of Milan, Milan, Italy. carla.ripamonti@istitutotumori.mi.it Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 137 EP - 145 VL - 20 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Index Medicus KW - Young Adult KW - Humans KW - Retrospective Studies KW - Academies and Institutes KW - Aged KW - Antineoplastic Agents -- adverse effects KW - Aged, 80 and over KW - Adult KW - Imidazoles -- therapeutic use KW - Incidence KW - Middle Aged KW - Italy -- epidemiology KW - Antineoplastic Agents -- therapeutic use KW - Female KW - Male KW - Diphosphonates -- therapeutic use KW - Neoplasms -- drug therapy KW - Osteonecrosis -- prevention & control KW - Bone Neoplasms -- epidemiology KW - Diphosphonates -- adverse effects KW - Osteonecrosis -- epidemiology KW - Jaw Diseases -- prevention & control KW - Neoplasms -- epidemiology KW - Osteonecrosis -- chemically induced KW - Neoplasms -- pathology KW - Bone Neoplasms -- drug therapy KW - Jaw Diseases -- chemically induced KW - Jaw Diseases -- epidemiology KW - Dental Prophylaxis -- utilization KW - Bone Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66830468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Decreased+occurrence+of+osteonecrosis+of+the+jaw+after+implementation+of+dental+preventive+measures+in+solid+tumour+patients+with+bone+metastases+treated+with+bisphosphonates.+The+experience+of+the+National+Cancer+Institute+of+Milan.&rft.au=Ripamonti%2C+C+I%3BManiezzo%2C+M%3BCampa%2C+T%3BFagnoni%2C+E%3BBrunelli%2C+C%3BSaibene%2C+G%3BBareggi%2C+C%3BAscani%2C+L%3BCislaghi%2C+E&rft.aulast=Ripamonti&rft.aufirst=C&rft.date=2009-01-01&rft.volume=20&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=1569-8041&rft_id=info:doi/10.1093%2Fannonc%2Fmdn526 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-19 N1 - Date created - 2009-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annonc/mdn526 ER - TY - JOUR T1 - Curing of yeast [URE3] prion by the Hsp40 cochaperone Ydj1p is mediated by Hsp70. AN - 66814114; 19015537 AB - [URE3] is a prion of the yeast Ure2 protein. Hsp40 is a cochaperone that regulates Hsp70 chaperone activity. When overexpressed, the Hsp40 Ydj1p cures yeast of [URE3], but the Hsp40 Sis1p does not. On the basis of biochemical data Ydj1p has been proposed to cure [URE3] by binding soluble Ure2p and preventing it from joining prion aggregates. Here, we mutagenized Ydj1p and find that disrupting substrate binding, dimerization, membrane association, or ability to transfer substrate to Hsp70 had little or no effect on curing. J-domain point mutations that disrupt functional interactions of Ydj1p with Hsp70 abolished curing, and the J domain alone cured [URE3]. Consistent with heterologous J domains possessing similar Hsp70 regulatory activity, the Sis1p J domain also cured [URE3]. We further show that Ydj1p is not essential for [URE3] propagation and that depletion of Ure2p is lethal in cells lacking Ydj1p. Our data imply that curing of [URE3] by overproduced Ydj1p does not involve direct interaction of Ydj1p with Ure2p but rather works through regulation of Hsp70 through a specific J-protein/Hsp70 interaction. JF - Genetics AU - Sharma, Deepak AU - Stanley, Robert F AU - Masison, Daniel C AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0851, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 129 EP - 137 VL - 181 IS - 1 SN - 0016-6731, 0016-6731 KW - HSP40 Heat-Shock Proteins KW - 0 KW - HSP70 Heat-Shock Proteins KW - Heat-Shock Proteins KW - Mutant Proteins KW - Prions KW - SIS1 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - YDJ1 protein, S cerevisiae KW - 139874-78-5 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - URE2 protein, S cerevisiae KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Microbial Viability KW - Mutant Proteins -- metabolism KW - Mutation -- genetics KW - Spores, Fungal -- cytology KW - Protein Structure, Tertiary KW - Prenylation KW - Protein Multimerization KW - Heat-Shock Proteins -- chemistry KW - Saccharomyces cerevisiae Proteins -- metabolism KW - HSP70 Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - HSP40 Heat-Shock Proteins -- chemistry KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Prions -- metabolism KW - HSP40 Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66814114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Curing+of+yeast+%5BURE3%5D+prion+by+the+Hsp40+cochaperone+Ydj1p+is+mediated+by+Hsp70.&rft.au=Sharma%2C+Deepak%3BStanley%2C+Robert+F%3BMasison%2C+Daniel+C&rft.aulast=Sharma&rft.aufirst=Deepak&rft.date=2009-01-01&rft.volume=181&rft.issue=1&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/10.1534%2Fgenetics.108.098699 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Plant Cell. 2000 Apr;12(4):457-60 [10760235] Mol Biol Cell. 2003 Mar;14(3):1172-81 [12631732] Curr Biol. 2000 Nov 16;10(22):1443-6 [11102806] EMBO J. 2001 May 15;20(10):2435-42 [11350932] Curr Microbiol. 2001 Jul;43(1):7-10 [11375656] Mol Cell Biol. 2001 Oct;21(20):7035-46 [11564886] Mol Cell Biol. 2002 Jun;22(11):3590-8 [11997496] Genetics. 2002 Nov;162(3):1045-53 [12454054] Genetics. 2003 Feb;163(2):495-506 [12618389] J Biol Chem. 2003 Nov 7;278(45):44457-66 [12941935] Structure. 2003 Dec;11(12):1475-83 [14656432] Mol Cell Biol. 2004 May;24(9):3928-37 [15082786] J Biol Chem. 2004 Oct 22;279(43):44376-83 [15302880] Genetics. 1989 May;122(1):19-27 [2659436] Methods Enzymol. 1991;194:281-301 [2005793] Methods Enzymol. 1991;194:3-21 [2005794] J Cell Biol. 1991 Aug;114(4):609-21 [1869583] J Biol Chem. 1992 Sep 15;267(26):18890-5 [1527016] Cell. 1992 Dec 24;71(7):1143-55 [1473150] Science. 1995 Oct 6;270(5233):93-5 [7569955] J Biol Chem. 1996 Apr 19;271(16):9347-54 [8621599] Mol Cell Biol. 1996 Sep;16(9):4773-81 [8756635] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12503-8 [9356479] Cell. 1998 Jul 10;94(1):73-82 [9674429] J Biol Chem. 1998 Oct 23;273(43):27824-30 [9774392] Protein Sci. 1999 Jan;8(1):203-14 [10210198] J Biol Chem. 1999 Oct 22;274(43):30534-9 [10521435] J Biol Chem. 2005 Jan 7;280(1):695-702 [15496404] Biochem J. 2005 Mar 15;386(Pt 3):453-60 [15500443] EMBO J. 2005 Sep 7;24(17):3082-92 [16096644] Cell. 2006 May 5;125(3):443-51 [16678092] Genetics. 2006 Jun;173(2):611-20 [16582428] J Biol Chem. 2007 Apr 20;282(16):11931-40 [17324933] Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7163-8 [17438278] Mol Biol Cell. 2007 Jun;18(6):2149-54 [17392510] Nat Rev Microbiol. 2007 Aug;5(8):611-8 [17632572] EMBO J. 2007 Aug 22;26(16):3794-803 [17673909] Proc Natl Acad Sci U S A. 2008 May 20;105(20):7206-11 [18480252] J Biol Chem. 2008 Jun 6;283(23):15732-9 [18400756] Mol Cell Biol. 2008 Jul;28(13):4434-44 [18443039] Genetics. 2008 Jul;179(3):1301-11 [18562668] J Mol Biol. 2008 Oct 31;383(1):155-66 [18723025] Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16596-601 [18955697] Mol Cell Biol. 2000 Dec;20(23):8916-22 [11073991] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1534/genetics.108.098699 ER - TY - JOUR T1 - Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. AN - 66811257; 19139015 AB - The increased molecular understanding of cancerous growth may now afford the opportunity to develop novel therapies targeting specific dysregulated molecular mechanisms contributing to the progression of each cancer type. In this regard, the aberrant activation of Akt/mammalian target of rapamycin (mTOR) pathway is a frequent event in head and neck squamous cell carcinomas (HNSCC), thus representing a potential molecular target for the treatment of HNSCC patients. The ability to translate this emerging body of information into effective therapeutic strategies, however, has been hampered by the limited availability of animal models for oral malignancies. Here, we show that the administration in the drinking water to mice of 4-nitroquinoline-1 oxide, a DNA adduct-forming agent that serves as a surrogate of tobacco exposure, leads to the progressive appearance of preneoplastic and tumoral lesions in the tongue and oral mucosa, with 100% incidence after only 16 weeks of carcinogen exposure. Remarkably, many of these lesions evolve spontaneously into highly malignant SCCs few weeks after 4-nitroquinoline-1 oxide withdrawal. In this model, we have observed that the activation of the Akt-mTOR biochemical route represents an early event, which is already detectable in dysplastic lesions. Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs. Together, these findings support the contribution of the mTOR signaling pathway to HNSCC progression and provide a strong rationale for the early evaluation of mTOR inhibitors as a molecular-targeted strategy for HNSCC chemoprevention and treatment. JF - Cancer prevention research (Philadelphia, Pa.) AU - Czerninski, Rakefet AU - Amornphimoltham, Panomwat AU - Patel, Vyomesh AU - Molinolo, Alfredo A AU - Gutkind, J Silvio AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Building 30, Bethesda, MD 20892-4340, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 27 EP - 36 VL - 2 IS - 1 KW - Antibiotics, Antineoplastic KW - 0 KW - Carcinogens KW - 4-Nitroquinoline-1-oxide KW - 56-57-5 KW - Protein Kinases KW - EC 2.7.- KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - mTOR protein, mouse KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinogens -- toxicity KW - Disease Progression KW - Cell Transformation, Neoplastic -- drug effects KW - Mice KW - 4-Nitroquinoline-1-oxide -- toxicity KW - Signal Transduction -- drug effects KW - Mice, Inbred C57BL KW - Immunohistochemistry KW - Female KW - Protein Kinases -- biosynthesis KW - Carcinoma, Squamous Cell -- metabolism KW - Head and Neck Neoplasms -- pathology KW - Precancerous Conditions -- drug therapy KW - Precancerous Conditions -- metabolism KW - Head and Neck Neoplasms -- drug therapy KW - Precancerous Conditions -- pathology KW - Head and Neck Neoplasms -- metabolism KW - Antibiotics, Antineoplastic -- pharmacology KW - Carcinoma, Squamous Cell -- pathology KW - Protein Kinases -- drug effects KW - Sirolimus -- pharmacology KW - Carcinoma, Squamous Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66811257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Targeting+mammalian+target+of+rapamycin+by+rapamycin+prevents+tumor+progression+in+an+oral-specific+chemical+carcinogenesis+model.&rft.au=Czerninski%2C+Rakefet%3BAmornphimoltham%2C+Panomwat%3BPatel%2C+Vyomesh%3BMolinolo%2C+Alfredo+A%3BGutkind%2C+J+Silvio&rft.aulast=Czerninski&rft.aufirst=Rakefet&rft.date=2009-01-01&rft.volume=2&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-08-0147 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-18 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Cancer Prev Res (Phila). 2009 Jan;2(1):10-3 [19139012] Cancer Prev Res (Phila). 2009 Jan;2(1):7-9 [19139011] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-08-0147 ER - TY - JOUR T1 - Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice. AN - 66811177; 19139019 AB - Although inflammatory cytokines and obesity-associated serum proteins have been reported as biomarkers of colorectal adenoma risk in humans, little is known of biomarkers of response to interventions that attenuate tumorigenesis. Dietary navy beans and their fractions attenuate colon carcinogenesis in carcinogen-induced genetically obese mice. We hypothesized that this attenuation would be associated with changes in inflammatory cytokines and obesity-related serum proteins that may serve as measures of efficacy. ob/ob mice (n = 160) were injected with the carcinogen azoxymethane (AOM) to induce colon cancer and randomly placed on one of four diets (control, whole navy bean, bean residue fraction, or bean extract fraction) for 26 to 28 wk. Serum was analyzed for 14 inflammation- or obesity-related proteins, and colon RNA was analyzed for expression of 84 inflammation-associated genes. Six of 14 serum proteins were increased [i.e., interleukin (IL)-4, IL-5, IL-6, IL-10, IFN gamma, granulocyte macrophage colony-stimulating factor] in hyperplastic/dysplastic stages of colon carcinogenesis. Bean-fed mice had significantly higher monocyte chemoattractant protein-1 and lower IL-6 levels in serum. In colon mucosa, 55 of 84 inflammation-associated genes differed between AOM-induced and noninduced mice. Of the 55 AOM-induced genes, 5 were counteracted by bean diets, including IL-6 whose increase in expression levels was attenuated by bean diets in AOM-induced mice. In summary, IL-6 emerged as a serum protein that was increased in hyperplastic/dysplastic stages of colon carcinogenesis, but attenuated with bean-based diet in serum and colon mucosa. Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis. JF - Cancer prevention research (Philadelphia, Pa.) AU - Mentor-Marcel, Roycelynn A AU - Bobe, Gerd AU - Barrett, Kathleen G AU - Young, Matthew R AU - Albert, Paul S AU - Bennink, Maurice R AU - Lanza, Elaine AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA. marcelr@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 60 EP - 69 VL - 2 IS - 1 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Cytokines KW - Interleukin-6 KW - Plant Extracts KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Precancerous Conditions -- diet therapy KW - Azoxymethane -- toxicity KW - Mice, Obese KW - Carcinogens -- toxicity KW - Mice KW - Precancerous Conditions -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Obesity -- complications KW - Precancerous Conditions -- genetics KW - Interleukin-6 -- genetics KW - Biomarkers, Tumor -- analysis KW - Diet KW - Interleukin-6 -- biosynthesis KW - Male KW - Fabaceae -- chemistry KW - Phytotherapy KW - Cytokines -- genetics KW - Colonic Neoplasms -- genetics KW - Cytokines -- biosynthesis KW - Colonic Neoplasms -- diet therapy KW - Inflammation -- genetics KW - Inflammation -- metabolism KW - Cytokines -- metabolism KW - Colonic Neoplasms -- metabolism KW - Plant Extracts -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66811177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Inflammation-associated+serum+and+colon+markers+as+indicators+of+dietary+attenuation+of+colon+carcinogenesis+in+ob%2Fob+mice.&rft.au=Mentor-Marcel%2C+Roycelynn+A%3BBobe%2C+Gerd%3BBarrett%2C+Kathleen+G%3BYoung%2C+Matthew+R%3BAlbert%2C+Paul+S%3BBennink%2C+Maurice+R%3BLanza%2C+Elaine%3BColburn%2C+Nancy+H&rft.aulast=Mentor-Marcel&rft.aufirst=Roycelynn&rft.date=2009-01-01&rft.volume=2&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-08-0086 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-18 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2007 Jun;92(6):2240-7 [17374712] Endocrinology. 2007 Jan;148(1):241-51 [17038556] Obesity (Silver Spring). 2007 Aug;15(8):1988-95 [17712116] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2128-35 [17932361] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2150-4 [17932364] Environ Health Perspect. 2007 Oct;115(10):1467-73 [17938737] J Nutr. 2007 Nov;137(11):2391-8 [17951475] Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1153-8 [17726148] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2373-8 [18006926] J Clin Invest. 2007 Dec;117(12):3660-3 [18060028] Cancer Res. 2008 Jan 1;68(1):323-8 [18172326] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Trends Mol Med. 2008 Mar;14(3):109-19 [18261959] Nutr Cancer. 2008;60(3):373-81 [18444172] Curr Opin Genet Dev. 2008 Feb;18(1):3-10 [18325755] Proc Natl Acad Sci U S A. 2008 May 27;105(21):7534-9 [18490655] Cancer. 2000 May 15;88(10):2398-424 [10820364] Lancet. 2001 Feb 17;357(9255):539-45 [11229684] Oncogene. 2002 Jun 6;21(25):3949-60 [12037677] Gastroenterology. 2002 Jun;122(7):2011-25 [12055606] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Nutr Cancer. 2002;44(1):60-5 [12672642] J Nutr. 2004 Oct;134(10):2673-7 [15465765] Physiol Rev. 1979 Jul;59(3):719-809 [379887] Endocrinology. 1980 Sep;107(3):671-6 [6249569] Science. 1993 Jan 1;259(5091):87-91 [7678183] J Nutr. 1993 Nov;123(11):1939-51 [8229312] Nutr Cancer. 1997;27(2):206-9 [9121951] J Clin Invest. 1997 Sep 1;100(5):1174-9 [9276734] J Nutr. 1997 Dec;127(12):2328-33 [9405582] J Clin Invest. 1998 Feb 15;101(4):746-54 [9466968] J Clin Endocrinol Metab. 1998 Mar;83(3):847-50 [9506738] Anticancer Res. 2004 Sep-Oct;24(5A):3049-55 [15517915] J Biol Chem. 2005 Mar 4;280(9):8260-5 [15613481] Cancer Res. 2005 Jun 1;65(11):4673-82 [15930285] Int J Cancer. 2005 Oct 10;116(6):949-56 [15856455] Obes Res. 2005 Aug;13(8):1311-20 [16129712] J Clin Endocrinol Metab. 2005 Oct;90(10):5834-40 [16091493] J Lipid Res. 2005 Nov;46(11):2347-55 [16150820] Eur J Cancer. 2005 Nov;41(16):2502-12 [16199153] Nat Clin Pract Oncol. 2005 Feb;2(2):90-7; quiz 1 p following 113 [16264881] Am J Clin Nutr. 2006 Feb;83(2):461S-465S [16470013] J Nutr Biochem. 2006 Mar;17(3):145-56 [16426829] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):389-94 [16492934] Proteomics. 2006 May;6(9):2844-52 [16596712] Br J Cancer. 2006 Jun 19;94(12):1898-905 [16755300] J Nutr. 2006 Jul;136(7):1896-903 [16772456] Obesity (Silver Spring). 2006 May;14(5):799-811 [16855189] Int J Obes (Lond). 2006 Sep;30(9):1347-55 [16534530] Mutat Res. 2007 Sep 1;622(1-2):103-16 [17574631] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-08-0086 ER - TY - JOUR T1 - Genetic signature for human risk assessment: lessons from trichloroethylene. AN - 66807296; 19031419 AB - Trichloroethylene (TCE), an organic solvent commonly used for metal degreasing and as a chemical additive, is a significant environmental contaminant that poses health concerns in humans. The US Environmental Protection Agency (EPA) is currently revising the 2001 TCE human risk assessment draft. The next draft is expected to be ready in 2008. TCE metabolites are detectable in humans and carry varying potencies for induction of cancers in animals. Genomic mechanisms have been explored in animals and humans to link TCE to carcinogenesis. DNA analysis provides an opportunity for detection of unique genetic alterations representing a signature of TCE exposure. These alterations can arise from genotoxic and nongenotoxic pathways at multiple points throughout tumorigenesis. Although fixation of alterations may require several stages of selection and modification, the spectra can be specific to TCE. Only a fraction of these alterations eventually lead to tumor formation and some contribute to tumor progression. Genetic events in two major TCE target organs are reviewed, including the VHL gene in kidney, and the Ras gene and genome-wide hypomethylation in liver. Attempts to identify a genetic signature of TCE exposure are challenged by inconsistent findings, lack of evidence of promutagenic lesions, biological relevance of specific genomic changes, and likelihood of coexposures. For human risk assessment, genome-wide screening is useful and is possible with the development of new DNA-sequencing technologies. Genetic screening for preneoplastic and tumor tissues from high-risk population is proposed to exclude the noise of passenger mutations and genetic polymorphisms. JF - Environmental and molecular mutagenesis AU - Shiao, Yih-Horng AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. shiao@mail.ncifcrf.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 68 EP - 77 VL - 50 IS - 1 KW - Trichloroethylene KW - 290YE8AR51 KW - Von Hippel-Lindau Tumor Suppressor Protein KW - EC 2.3.2.27 KW - VHL protein, human KW - EC 6.3.2.- KW - Index Medicus KW - United States KW - Kidney Neoplasms -- genetics KW - United States Environmental Protection Agency KW - Kidney Neoplasms -- chemically induced KW - Humans KW - Von Hippel-Lindau Tumor Suppressor Protein -- genetics KW - Environmental Exposure KW - Mutation KW - Risk Assessment KW - Trichloroethylene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66807296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Genetic+signature+for+human+risk+assessment%3A+lessons+from+trichloroethylene.&rft.au=Shiao%2C+Yih-Horng&rft.aulast=Shiao&rft.aufirst=Yih-Horng&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20432 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Genet. 2008 Mar;24(3):133-41 [18262675] Environ Health Perspect. 2000 May;108 Suppl 2:177-200 [10807551] Environ Health Perspect. 2000 May;108 Suppl 2:215-23 [10807553] Environ Health Perspect. 2000 Jul;108(7):579-88 [10905993] Ann N Y Acad Sci. 2000;919:79-85 [11083100] Science. 2001 Feb 16;291(5507):1304-51 [11181995] Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1583-8 [11171994] Nature. 2001 Feb 15;409(6822):860-921 [11237011] Curr Opin Neurol. 2001 Dec;14(6):695-703 [11723376] Toxicol Appl Pharmacol. 2002 Jul 1;182(1):55-65 [12127263] Nat Genet. 2002 Dec;32(4):614-21 [12415268] Nature. 2002 Dec 5;420(6915):520-62 [12466850] Science. 2003 Apr 18;300(5618):489-92 [12702876] Lancet. 2003 Jun 14;361(9374):2059-67 [12814730] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8424-9 [12826609] Cancer Res. 2003 Sep 1;63(17):5320-8 [14500363] Curr Med Chem. 2003 Nov;10(22):2461-70 [14529485] Hum Mutat. 2004 Jan;23(1):40-6 [14695531] Toxicology. 2004 Mar 1;196(1-2):127-36 [15036762] IARC Sci Publ. 2004;(157):247-70 [15055300] Nature. 2004 Apr 1;428(6982):493-521 [15057822] Toxicol Lett. 2004 Jun 15;151(1):301-10 [15177666] Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:40-8 [15209402] Nature. 1975 Mar 20;254(5497):261-2 [1113893] Annu Rev Genet. 1986;20:201-30 [3545059] Science. 1990 Sep 14;249(4974):1288-90 [1697983] Science. 1991 Nov 15;254(5034):1001-3 [1948068] J Biol Chem. 1992 Jan 5;267(1):166-72 [1730583] Carcinogenesis. 1994 Oct;15(10):2255-61 [7955063] Mutagenesis. 1994 Sep;9(5):429-37 [7837977] Environ Health Perspect. 1994 Sep;102 Suppl 3:57-61 [7843138] Carcinogenesis. 1995 Mar;16(3):495-500 [7697804] Cancer Lett. 1995 Jun 29;93(1):17-48 [7600541] Nat Med. 1995 Aug;1(8):822-6 [7585187] Regul Toxicol Pharmacol. 1996 Feb;23(1 Pt 1):2-13 [8628915] Science. 1996 Oct 18;274(5286):430-2 [8832894] Cancer Lett. 1996 Nov 29;108(2):257-61 [8973603] IARC Monogr Eval Carcinog Risks Hum. 1995;63:33-477 [9139128] Arch Toxicol. 1997;71(5):332-5 [9137812] Mutat Res. 1997 Apr 24;390(1-2):51-7 [9150752] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9102-7 [9256442] Chem Biol Interact. 1997 Sep 12;106(2):109-21 [9366897] Chem Res Toxicol. 1998 Sep;11(9):1082-8 [9760283] J Natl Cancer Inst. 1998 Nov 18;90(22):1720-3 [9827526] J Natl Cancer Inst. 1999 May 19;91(10):854-61 [10340905] Proc R Soc Med. 1965 May;58:295-300 [14283879] Cell. 2004 Dec 17;119(6):847-60 [15607980] Cell. 2004 Dec 17;119(6):861-72 [15607981] Pharmacogenomics. 2005 Jun;6(4):373-82 [16004555] Hum Mutat. 2005 Sep;26(3):184-91 [16086365] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] Bull World Health Organ. 2005 Oct;83(10):792-5 [16283057] Cancer Res. 2006 Mar 1;66(5):2576-83 [16510575] Genetics. 2006 Aug;173(4):2187-98 [16783027] Environ Health Perspect. 2006 Sep;114(9):1457-63 [16966105] Environ Health Perspect. 2006 Sep;114(9):1471-8 [16966107] Science. 2006 Oct 13;314(5797):268-74 [16959974] Hum Mutat. 2007 Feb;28(2):143-9 [17024664] Nature. 2007 Mar 8;446(7132):153-8 [17344846] World J Gastroenterol. 2007 Apr 28;13(16):2271-82 [17511024] Cancer Genomics Proteomics. 2007 May-Jun;4(3):111-9 [17878515] Cancer Cell. 2007 Oct;12(4):303-12 [17936556] Front Biosci. 2008;13:71-84 [17981529] Oncogene. 2008 Jan 10;27(3):404-8 [17621273] Environ Mol Mutagen. 2008 Mar;49(2):142-54 [17973308] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20432 ER - TY - JOUR T1 - Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use. AN - 66806238; 19124692 AB - In ecological momentary assessment (EMA), participants electronically report their activities and moods in their daily environments in real time, enabling a truly prospective approach to the study of acute precipitants of behavioral events. Ecological momentary assessment has greatly enhanced the study of tobacco addiction, but its use has rarely been attempted in individuals with cocaine or heroin addiction. To prospectively monitor the acute daily life precipitants of craving for and use of cocaine and heroin. Cohort study. A volunteer sample of 114 cocaine- and heroin-abusing outpatients who were being treated with methadone provided EMA data on handheld electronic devices for 14 918 person-days (mean, 130.9; range, 6-189 days per participant). Of these outpatients, a total of 102 (63 men, 39 women) provided acute precraving and/or preuse data and were thus included in the present analyses. Changes in reports of mood and exposure to 12 putative drug-use triggers at random intervals during the 5 hours preceding each self-reported episode of drug craving or use, analyzed via repeated-measures logistic regression (generalized linear mixed models). During the 5 hours preceding cocaine use or heroin craving, most of the 12 putative triggers showed linear increases. Cocaine use was most robustly associated with increases in participants reporting that they "saw [the] drug" (P < .001), were "tempted to use out of the blue" (P < .001), "wanted to see what would happen if I used" (P < .001), and were in a good mood (P < .001). Heroin craving was most robustly associated with increases in reports of feeling sad (P < .001) or angry (P = .01). Cocaine craving and heroin use showed few reliable associations with any of the putative triggers assessed. These findings confirm that polydrug-abusing individuals can provide behavioral data in their daily environments using handheld electronic devices and that those data can reveal orderly patterns, including prospectively detectable harbingers of craving and use, which may differ across drugs. JF - Archives of general psychiatry AU - Epstein, David H AU - Willner-Reid, Jessica AU - Vahabzadeh, Massoud AU - Mezghanni, Mustapha AU - Lin, Jia-Ling AU - Preston, Kenzie L AD - National Institute on Drug Abuse Intramural Research Program, Treatment Section, Clinical Pharmacology and Therapeutics Branch, Baltimore, MD 21224, USA. depstein@intra.nida.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 88 EP - 94 VL - 66 IS - 1 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Methadone -- therapeutic use KW - Combined Modality Therapy KW - Humans KW - Counseling KW - Recurrence KW - Ambulatory Care KW - Prospective Studies KW - Token Economy KW - Adult KW - Narcotics -- therapeutic use KW - Middle Aged KW - Female KW - Male KW - Social Environment KW - Substance Withdrawal Syndrome -- rehabilitation KW - Motivation KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Heroin Dependence -- rehabilitation KW - Substance Withdrawal Syndrome -- psychology KW - Affect KW - Computers, Handheld KW - Heroin Dependence -- psychology KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66806238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+and+neuroscience&rft.atitle=EEG+and+cerebral+blood+flow+velocity+abnormalities+in+chronic+cocaine+users.&rft.au=Copersino%2C+Marc+L%3BHerning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean-Lud%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2009-01-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+and+neuroscience&rft.issn=15500594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2009-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addiction. 2000 Jun;95(6):889-900 [10946438] Drug Alcohol Depend. 1998 Nov 1;52(3):183-92 [9839144] J Subst Abuse Treat. 2001 Sep;21(2):77-87 [11551736] Psychol Addict Behav. 2002 Sep;16(3):205-11 [12236455] J Abnorm Psychol. 2002 Nov;111(4):531-45 [12428767] Psychol Addict Behav. 2003 Mar;17(1):73-82 [12665084] Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20 [12402102] Psychopharmacology (Berl). 2003 Jul;168(1-2):31-41 [12721778] J Clin Psychol. 2004 Feb;60(2):179-88 [14724925] Psychol Rev. 2004 Jan;111(1):33-51 [14756584] J Consult Clin Psychol. 2004 Apr;72(2):192-201 [15065954] J Consult Clin Psychol. 1990 Apr;58(2):175-81 [2335634] Addict Behav. 1991;16(1-2):41-9 [2048457] J Consult Clin Psychol. 1996 Apr;64(2):366-79 [8871421] J Consult Clin Psychol. 1997 Feb;65(1):178-83 [9103747] Drug Alcohol Depend. 2005 Jun 1;78(3):275-81 [15893158] J Subst Abuse Treat. 2006 Mar;30(2):105-11 [16490673] Drug Alcohol Depend. 2006 Dec 1;85(3):221-35 [16730923] Schizophr Res. 2008 Jan;98(1-3):312-7 [17920245] Psychol Sci. 2000 Nov;11(6):446-53 [11202488] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archgenpsychiatry.2008.509 ER - TY - JOUR T1 - Jupiter to earth: a statin helps people with normal LDL-C and high hs-CRP, but what does it mean? AN - 66802173; 19122109 AB - The JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) (N Engl J Med 2008; 359:2195-2207) compared rosuvastatin (Crestor) 20 mg daily vs placebo in apparently healthy people who had levels of low-density lipoprotein cholesterol (LDL-C) lower than 130 mg/dL but elevated levels (>or= 2 mg/L) of high-sensitivity C-reactive protein (hs-CRP). Rosuvastatin treatment lowered LDL-C levels by 50% and hs-CRP levels by 37%, accompanied by a 44% relative risk reduction in the composite end point of unstable angina, revascularization, and confirmed death from cardiovascular causes. In absolute terms, 95 people had to be treated over 2 years to prevent one event. There was, however, a higher incidence of diabetes in the rosuvastatin group. JF - Cleveland Clinic journal of medicine AU - Shishehbor, Mehdi H AU - Hazen, Stanley L AD - National Institutes of Health CTSA-KL2 Scholar, Department of Interventional Cardiology, Heart and Vascular Institute, Cleveland Clinic , Cleveland, OH 44195, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 37 EP - 44 VL - 76 IS - 1 KW - Cholesterol, LDL KW - 0 KW - Fluorobenzenes KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Pyrimidines KW - Sulfonamides KW - Rosuvastatin Calcium KW - 83MVU38M7Q KW - C-Reactive Protein KW - 9007-41-4 KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Female KW - Pyrimidines -- adverse effects KW - Cholesterol, LDL -- blood KW - Sulfonamides -- adverse effects KW - Pyrimidines -- therapeutic use KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Fluorobenzenes -- adverse effects KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use KW - Fluorobenzenes -- therapeutic use KW - Sulfonamides -- therapeutic use KW - C-Reactive Protein -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66802173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cleveland+Clinic+journal+of+medicine&rft.atitle=Jupiter+to+earth%3A+a+statin+helps+people+with+normal+LDL-C+and+high+hs-CRP%2C+but+what+does+it+mean%3F&rft.au=Shishehbor%2C+Mehdi+H%3BHazen%2C+Stanley+L&rft.aulast=Shishehbor&rft.aufirst=Mehdi&rft.date=2009-01-01&rft.volume=76&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Cleveland+Clinic+journal+of+medicine&rft.issn=1939-2869&rft_id=info:doi/10.3949%2Fccjm.75a.08105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-24 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Cardiol. 2001 Mar 8;87(5A):28B-32B [11256847] JAMA. 2001 Apr 4;285(13):1711-8 [11277825] Circulation. 2001 Apr 3;103(13):1813-8 [11282915] JAMA. 2001 Jul 4;286(1):64-70 [11434828] Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1712-9 [11701455] Int J Clin Pract. 2002 Jan-Feb;56(1):53-6 [11831837] JAMA. 2002 Jun 26;287(24):3215-22 [12076217] Eur Heart J. 2002 Dec;23(24):1931-7 [12473255] Circulation. 2003 Jan 28;107(3):391-7 [12551861] Circulation. 2003 Jan 28;107(3):499-511 [12551878] JAMA. 2003 Apr 2;289(13):1675-80 [12672736] Cleve Clin J Med. 2003 Jul;70(7):634-40 [12882386] Circulation. 2003 Jul 29;108(4):426-31 [12860913] Curr Probl Cardiol. 2003 May;28(5):317-47 [14614445] JAMA. 2004 Mar 3;291(9):1071-80 [14996776] Curr Atheroscler Rep. 2004 May;6(3):243-50 [15068750] N Engl J Med. 2004 Apr 1;350(14):1387-97 [15070788] N Engl J Med. 2004 Apr 8;350(15):1495-504 [15007110] N Engl J Med. 2004 Apr 8;350(15):1562-4 [15007111] Circulation. 2001 Jan 16;103(2):276-83 [11208689] Circulation. 2004 Jul 13;110(2):227-39 [15249516] JAMA. 2004 Sep 15;292(11):1307-16 [15337732] Expert Opin Drug Saf. 2004 Nov;3(6):547-57 [15500414] Lancet. 1996 Nov 16;348(9038):1339-42 [8918276] N Engl J Med. 1997 Apr 3;336(14):973-9 [9077376] Circulation. 1998 May 26;97(20):2007-11 [9610529] JAMA. 1998 May 27;279(20):1615-22 [9613910] Circulation. 1998 Aug 25;98(8):731-3 [9727541] N Engl J Med. 1999 Jul 8;341(2):70-6 [10395630] Circulation. 1999 Jul 20;100(3):230-5 [10411845] Am J Cardiol. 2004 Nov 1;94(9):1140-6 [15518608] N Engl J Med. 2005 Jan 6;352(1):20-8 [15635109] N Engl J Med. 2005 Jan 6;352(1):29-38 [15635110] N Engl J Med. 2005 Apr 7;352(14):1425-35 [15755765] Circ Res. 2005 Apr 15;96(7):714-6 [15774855] JAMA. 2005 May 11;293(18):2245-56 [15886380] Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1102-11 [15790935] Circulation. 2005 Jul 5;112(1):25-31 [15983251] N Engl J Med. 2005 Jul 7;353(1):93-6; author reply 93-6 [16003832] Circulation. 2005 Aug 16;112(7):1016-23 [16087790] Am J Cardiol. 2005 Sep 5;96(5A):24F-33F [16126020] Lancet. 2005 Oct 8;366(9493):1267-78 [16214597] J Am Coll Cardiol. 2005 Oct 18;46(8):1405-10 [16226162] J Am Coll Cardiol. 2005 Nov 15;46(10):1855-62 [16286171] JAMA. 2005 Nov 16;294(19):2437-45 [16287954] Am J Cardiol. 2006 Apr 17;97(8A):44C-51C [16581328] Am J Cardiol. 2006 Apr 17;97(8A):82C-85C [16581334] JAMA. 2006 Apr 5;295(13):1556-65 [16533939] Cleve Clin J Med. 2006 Aug;73(8):760-6 [16913201] Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):134-40 [17068284] Eur Heart J. 2007 Mar;28(6):664-72 [17242008] J Am Coll Cardiol. 2007 May 1;49(17):1753-62 [17466224] J Am Coll Cardiol. 2007 May 29;49(21):2129-38 [17531663] JAMA. 2008 Mar 19;299(11):1265-76 [18349088] J Am Coll Cardiol. 2008 Apr 29;51(17):1653-62 [18436117] J Am Coll Cardiol. 2008 Jul 1;52(1):24-32 [18582631] N Engl J Med. 2008 Aug 14;359(7):760; author reply 761 [18703482] N Engl J Med. 2008 Oct 30;359(18):1897-908 [18971492] Arch Intern Med. 2002 Apr 22;162(8):867-9 [11966336] N Engl J Med. 2008 Nov 20;359(21):2280-2 [18997195] N Engl J Med. 2008 Nov 20;359(21):2195-207 [18997196] N Engl J Med. 2008 Oct 30;359(18):1953-5 [18971498] N Engl J Med. 1999 Dec 9;341(24):1853-4; author reply 1854-5 [10610464] Adv Intern Med. 2000;45:391-418 [10635056] N Engl J Med. 2000 Mar 23;342(12):836-43 [10733371] Curr Cardiol Rep. 2000 Jul;2(4):269-73 [10953258] Clin Chem. 2001 Mar;47(3):403-11 [11238289] JAMA. 2001 May 16;285(19):2481-5 [11368701] JAMA. 2001 May 16;285(19):2486-97 [11368702] N Engl J Med. 2001 Jun 28;344(26):1959-65 [11430324] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3949/ccjm.75a.08105 ER - TY - JOUR T1 - LX211 (voclosporin) suppresses experimental uveitis and inhibits human T cells. AN - 66795572; 18708627 AB - To test the therapeutic effectiveness of voclosporin against experimental autoimmune uveoretinitis (EAU) in rats and to evaluate its effect on human T cells. EAU was induced by immunization with a uveitogenic protein. Voclosporin administration, by subcutaneous injection, began on day (d) 0 or d7 after immunization. Treatment effectiveness was evaluated in vivo using clinical EAU scoring (d7-d13) and histopathologic evaluation of enucleated eyes after experimental termination. Rodent lymphocytes were harvested from lymph nodes on d14 for antigen-specific proliferation assays. The effect of voclosporin on human T-cell proliferation and cytokine secretion was examined in vitro. Voclosporin prevented EAU development in rats receiving medium and high preventive doses, whereas high-dose voclosporin administration effectively treated EAU. Lymphocytes from animals treated with voclosporin had decreased antigen-specific proliferation in vitro compared with lymphocytes from untreated animals. No evidence of abnormal ocular histopathology was found in the eyes from animals that received high doses of therapeutic voclosporin. Using human T cells, voclosporin inhibited human T-cell proliferation up to 100-fold. Furthermore, voclosporin treatment of human T cells significantly reduced pan T-cell effector responses. Voclosporin effectively suppressed uveoretinitis in an animal model that imitates the human inflammatory ocular disease by inhibiting lymphocyte proliferation. In addition, voclosporin effectively inhibited human T-cell proliferation and function in vitro. The authors report the first evidence supporting the application of voclosporin to treat intraocular inflammation. JF - Investigative ophthalmology & visual science AU - Cunningham, Matthew A AU - Austin, Bobbie Ann AU - Li, Zhuqing AU - Liu, Baoying AU - Yeh, Steven AU - Chan, Chi-Chao AU - Anglade, Eddy AU - Velagaleti, Poonam AU - Nussenblatt, Robert B AD - National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 249 EP - 255 VL - 50 IS - 1 KW - Cytokines KW - 0 KW - Eye Proteins KW - Immunosuppressive Agents KW - Retinol-Binding Proteins KW - interstitial retinol-binding protein KW - voclosporin KW - 2PN063X6B1 KW - Cyclosporine KW - 83HN0GTJ6D KW - Index Medicus KW - Rats KW - Lymphocyte Activation -- drug effects KW - Animals KW - Rats, Inbred Lew KW - Humans KW - Treatment Outcome KW - Injections, Subcutaneous KW - Cytokines -- metabolism KW - Male KW - Uveitis -- prevention & control KW - Autoimmune Diseases -- prevention & control KW - Retinitis -- immunology KW - Retinitis -- prevention & control KW - Disease Models, Animal KW - Uveitis -- immunology KW - Retinitis -- chemically induced KW - Immunosuppressive Agents -- pharmacology KW - Cyclosporine -- pharmacology KW - Autoimmune Diseases -- chemically induced KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- immunology KW - Uveitis -- chemically induced KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66795572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=LX211+%28voclosporin%29+suppresses+experimental+uveitis+and+inhibits+human+T+cells.&rft.au=Cunningham%2C+Matthew+A%3BAustin%2C+Bobbie+Ann%3BLi%2C+Zhuqing%3BLiu%2C+Baoying%3BYeh%2C+Steven%3BChan%2C+Chi-Chao%3BAnglade%2C+Eddy%3BVelagaleti%2C+Poonam%3BNussenblatt%2C+Robert+B&rft.aulast=Cunningham&rft.aufirst=Matthew&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=1552-5783&rft_id=info:doi/10.1167%2Fiovs.08-1891 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2009-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Nephrol Hypertens. 1995 Nov;4(6):472-7 [8591053] Ren Physiol Biochem. 1995 May-Jun;18(3):128-39 [7542793] Ophthalmology. 1998 Nov;105(11):2028-34 [9818601] Ophthalmology. 1999 Apr;106(4):723-8 [10201592] Clin Exp Immunol. 1999 Sep;117(3):455-61 [10469047] Transpl Int. 2005 May;17(12):767-71 [15827754] J Nephrol. 2005 Jul-Aug;18(4):453-7 [16245254] J Am Acad Dermatol. 2006 Mar;54(3):472-8 [16488299] Int Ophthalmol Clin. 2006 Fall;46(4):105-22 [17060797] Br J Ophthalmol. 2007 Feb;91(2):237-42 [16987901] Ophthalmology. 2007 May;114(5):1000-6 [17467532] Nat Med. 2007 Jun;13(6):711-8 [17496900] Expert Opin Investig Drugs. 2007 Oct;16(10):1525-40 [17922618] Bone Marrow Transplant. 2008 Feb;41(3):293-302 [17982500] J Exp Med. 2008 Apr 14;205(4):799-810 [18391061] Transplant Proc. 2001 Feb-Mar;33(1-2):1048-51 [11267185] J Ocul Pharmacol Ther. 2001 Apr;17(2):181-7 [11324985] J Rheumatol. 2002 Aug;29(8):1646-52 [12180723] J Heart Lung Transplant. 2003 Dec;22(12):1343-52 [14672749] Br J Ophthalmol. 2004 Mar;88(3):412-6 [14977779] Mol Interv. 2004 Apr;4(2):97-107 [15087483] Methods Mol Med. 2004;102:395-419 [15286397] Transplantation. 2004 Sep 15;78(5):681-5 [15371668] J Clin Invest. 1981 Apr;67(4):1228-31 [7204576] Invest Ophthalmol Vis Sci. 1985 Feb;26(2):226-32 [3871750] Biochemistry. 1985 Jan 29;24(3):787-93 [4039604] Transplant Proc. 1988 Jun;20(3 Suppl 4):122-7 [3381266] Invest Ophthalmol Vis Sci. 1988 Aug;29(8):1265-71 [2458329] J Ocul Pharmacol. 1985 Winter;1(4):369-82 [3880086] J Autoimmun. 1990 Jun;3(3):247-55 [2397018] Autoimmunity. 1990;8(1):43-51 [1717008] Photochem Photobiol. 1991 Dec;54(6):1057-60 [1775528] Biochem Pharmacol. 1992 Mar 3;43(5):1021-4 [1313235] Am J Ophthalmol. 1994 Jul 15;118(1):39-45 [8023874] Br J Ophthalmol. 1996 Sep;80(9):844-8 [8962842] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1167/iovs.08-1891 ER - TY - JOUR T1 - Enhancement of DNA tumor vaccine efficacy by gene gun-mediated codelivery of threshold amounts of plasmid-encoded helper antigen. AN - 66784619; 18832136 AB - Nucleic acid-based vaccines are effective in infectious disease models but have yielded disappointing results in tumor models when tumor-associated self-antigens are used. Incorporation of helper epitopes from foreign antigens into tumor vaccines might enhance the immunogenicity of DNA vaccines without increasing toxicity. However, generation of fusion constructs encoding both tumor and helper antigens may be difficult, and resulting proteins have unpredictable physical and immunologic properties. Furthermore, simultaneous production of equal amounts of highly immunogenic helper and weakly immunogenic tumor antigens in situ could favor development of responses against the helper antigen rather than the antigen of interest. We assessed the ability of 2 helper antigens (beta-galactosidase or fragment C of tetanus toxin) encoded by one plasmid to augment responses to a self-antigen (lymphoma-associated T-cell receptor) encoded by a separate plasmid after codelivery into skin by gene gun. This approach allowed adjustment of the relative ratios of helper and tumor antigen plasmids to optimize helper effects. Incorporation of threshold (minimally immunogenic) amounts of helper antigen plasmid into a DNA vaccine regimen dramatically increased T cell-dependent protective immunity initiated by plasmid-encoded tumor-associated T-cell receptor antigen. This simple strategy can easily be incorporated into future vaccine trials in experimental animals and possibly in humans. JF - Blood AU - Leitner, Wolfgang W AU - Baker, Matthew C AU - Berenberg, Thomas L AU - Lu, Michael C AU - Yannie, P Josef AU - Udey, Mark C AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 37 EP - 45 VL - 113 IS - 1 KW - Antigens, Neoplasm KW - 0 KW - Cancer Vaccines KW - Epitopes, T-Lymphocyte KW - Peptide Fragments KW - Receptors, Antigen, T-Cell, alpha-beta KW - Tetanus Toxin KW - Vaccines, DNA KW - tetanus toxin fragment C KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cell Line, Tumor KW - Epitopes, T-Lymphocyte -- immunology KW - Mice KW - Plasmids -- pharmacology KW - Epitopes, T-Lymphocyte -- genetics KW - Transfection KW - Antibody Formation -- immunology KW - Receptors, Antigen, T-Cell, alpha-beta -- immunology KW - Kidney -- cytology KW - Mice, Inbred C57BL KW - Antigens, Neoplasm -- immunology KW - Receptors, Antigen, T-Cell, alpha-beta -- genetics KW - T-Lymphocytes -- immunology KW - Female KW - Cricetinae KW - Tetanus Toxin -- immunology KW - Cancer Vaccines -- pharmacology KW - Vaccines, DNA -- immunology KW - Cancer Vaccines -- immunology KW - Peptide Fragments -- genetics KW - Vaccines, DNA -- pharmacology KW - Tetanus Toxin -- genetics KW - Biolistics -- methods KW - beta-Galactosidase -- genetics KW - Lymphoma, T-Cell -- immunology KW - beta-Galactosidase -- immunology KW - Peptide Fragments -- immunology KW - Lymphoma, T-Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66784619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Enhancement+of+DNA+tumor+vaccine+efficacy+by+gene+gun-mediated+codelivery+of+threshold+amounts+of+plasmid-encoded+helper+antigen.&rft.au=Leitner%2C+Wolfgang+W%3BBaker%2C+Matthew+C%3BBerenberg%2C+Thomas+L%3BLu%2C+Michael+C%3BYannie%2C+P+Josef%3BUdey%2C+Mark+C&rft.aulast=Leitner&rft.aufirst=Wolfgang&rft.date=2009-01-01&rft.volume=113&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-01-136267 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Feb 1;162(3):1749-55 [9973438] J Immunother. 1998 Nov;21(6):399-408 [9807734] J Virol. 1999 Mar;73(3):2280-7 [9971811] Vaccine. 1999 Feb 12;17(6):589-96 [10075166] Nat Med. 1999 Jul;5(7):823-7 [10395329] Vaccine. 2005 Jan 19;23(9):1114-25 [15629354] Med Hypotheses. 2006;67(1):71-4 [16513289] Intervirology. 2006;49(4):249-52 [16601357] Trends Mol Med. 2006 May;12(5):216-22 [16621717] J Clin Oncol. 2006 Jul 1;24(19):3107-12 [16754937] Adv Cancer Res. 2006;95:203-47 [16860659] Arch Virol. 2006 Nov;151(11):2133-48 [16791442] Clin Immunol. 2006 Nov;121(2):177-85 [16914381] J Virol. 2006 Dec;80(24):11991-7 [17005652] Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):540-9 [17255276] Scand J Immunol. 2007 Mar;65(3):240-8 [17309778] Vaccine. 2007 May 10;25(19):3731-41 [17350735] Curr Cancer Drug Targets. 2007 May;7(3):259-71 [17504123] Cancer Res. 2007 Jul 1;67(13):6459-67 [17616707] Cancer Res. 2007 Sep 1;67(17):7945-7 [17804699] Cancer Immunol Immunother. 2008 Nov;57(11):1635-45 [18386000] J Immunol. 2001 May 1;166(9):5366-73 [11313372] Vaccine. 1999 Dec 10;18(9-10):815-24 [10580194] Cancer Res. 2000 Jan 1;60(1):51-5 [10646851] J Immunol. 2000 Jul 15;165(2):869-77 [10878361] Curr Oncol Rep. 2000 Jan;2(1):38-47 [11122823] Vaccine. 2001 Mar 21;19(17-19):2647-56 [11257404] J Immunol. 2001 Aug 1;167(3):1558-65 [11466377] Curr Pharm Des. 2001 Nov;7(16):1641-67 [11562304] J Immunol. 2001 Nov 15;167(10):5549-57 [11698425] Dev Biol (Basel). 2000;104:181-5 [11713818] Cancer Res. 2002 Mar 15;62(6):1757-60 [11912151] Nat Med. 2003 Jan;9(1):33-9 [12496961] J Mol Med (Berl). 2003 Feb;81(2):71-86 [12601523] Hum Gene Ther. 2003 May 20;14(8):709-14 [12804135] J Immunol. 2003 Dec 15;171(12):6396-405 [14662838] J Immunol. 2004 Jan 15;172(2):929-36 [14707065] Expert Rev Vaccines. 2004 Apr;3(2):151-62 [15056041] Vaccine. 2004 May 7;22(15-16):2031-41 [15121317] Expert Opin Biol Ther. 2004 Jun;4(6):889-900 [15174971] DNA Cell Biol. 2004 Jun;23(6):395-402 [15231073] Nat Immunol. 2004 Nov;5(11):1143-8 [15475958] Infect Immun. 2004 Nov;72(11):6519-27 [15501783] J Immunol Methods. 1984 Mar 16;67(2):321-36 [6707474] J Immunol Methods. 1987 Apr 2;98(1):11-22 [2435806] J Immunol. 1988 Sep 15;141(6):2168-74 [3049800] Infect Immun. 1990 Apr;58(4):1004-9 [2318526] J Virol. 1996 Nov;70(11):7773-82 [8892898] J Immunol. 1997 Dec 1;159(11):5516-27 [9548492] J Immunol. 1997 Dec 15;159(12):6112-9 [9550412] J Exp Med. 1998 Sep 21;188(6):1075-82 [9743526] J Immunol. 1999 Feb 15;162(4):2251-8 [9973501] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-01-136267 ER - TY - JOUR T1 - Tumor vasculature-targeted delivery of tumor necrosis factor-alpha. AN - 66784051; 19090007 AB - Recently, considerable efforts have been directed toward antivascular therapy as a new modality to treat human cancers. However, targeting a therapeutic gene of interest to the tumor vasculature with minimal toxicity to other tissues remains the objective of antivascular gene therapy. Tumor necrosis factor-alpha (TNF-alpha) is a potent antivascular agent but has limited clinical utility because of significant systemic toxicity. At the maximum tolerated doses of systemic TNF-alpha, there is no meaningful antitumor activity. Hence, the objective of this study was to deliver TNF-alpha targeted to tumor vasculature by systemic delivery to examine its antitumor activity. A hybrid adeno-associated virus phage vector (AAVP) was used that targets tumor endothelium to express TNF-alpha (AAVP-TNF-alpha). The activity of AAVP-TNF-alpha was analyzed in various in vitro and in vivo settings using a human melanoma tumor model. In vitro, AAVP-TNF-alpha infection of human melanoma cells resulted in high levels of TNF-alpha expression. Systemic administration of targeted AAVP-TNF-alpha to melanoma xenografts in mice produced the specific delivery of virus to tumor vasculature. In contrast, the nontargeted vector did not target to tumor vasculature. Targeted AAVP delivery resulted in expression of TNF-alpha, induction of apoptosis in tumor vessels, and significant inhibition of tumor growth. No systemic toxicity to normal organs was observed. Targeted AAVP vectors can be used to deliver TNF-alpha specifically to tumor vasculature, potentially reducing its systemic toxicity. Because TNF-alpha is a promising antivascular agent that currently is limited by its toxicity, the current results suggest the potential for clinical translation of this strategy. JF - Cancer AU - Tandle, Anita AU - Hanna, Engy AU - Lorang, Dominique AU - Hajitou, Amin AU - Moya, Catherine A AU - Pasqualini, Renata AU - Arap, Wadih AU - Adem, Asha AU - Starker, Elizabeth AU - Hewitt, Stephen AU - Libutti, Steven K AD - Tumor Angiogenesis Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 128 EP - 139 VL - 115 IS - 1 SN - 0008-543X, 0008-543X KW - Tumor Necrosis Factor-alpha KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Melanoma, Experimental -- blood supply KW - Humans KW - Genetic Vectors KW - Transduction, Genetic KW - Gene Expression KW - Dependovirus -- genetics KW - Genetic Therapy -- methods KW - Mice, Nude KW - Mice KW - Cell Line, Tumor KW - Melanoma, Experimental -- therapy KW - Skin Neoplasms -- therapy KW - Skin Neoplasms -- blood supply KW - Melanoma -- therapy KW - Tumor Necrosis Factor-alpha -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Melanoma -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66784051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+disabilities+research+reviews&rft.atitle=Fetal+alcohol+spectrum+disorders%3A+when+science%2C+medicine%2C+public+policy%2C+and+laws+collide.&rft.au=Warren%2C+Kenneth+R%3BHewitt%2C+Brenda+G&rft.aulast=Warren&rft.aufirst=Kenneth&rft.date=2009-01-01&rft.volume=15&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Developmental+disabilities+research+reviews&rft.issn=1940-5529&rft_id=info:doi/10.1002%2Fddrr.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-10 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.24001 ER - TY - JOUR T1 - Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis. AN - 66781886; 19118017 AB - Transgenic mice that overexpress PKCalpha in the epidermis (K5-PKCalpha mice) exhibit acute CXCR2-mediated intraepidermal neutrophilic inflammation and a strong epidermal hyperplasia in response to application of 12-O-tetradecanoylphorbol-13-acetate (TPA). We now show that hyperplasia is independent of infiltrating neutrophils. Furthermore, when K5-PKCalpha mice were initiated with 7,12-dimethylbenz(a)anthracene (DMBA) and promoted with a low dose of TPA, 58% of K5-PKCalpha mice developed skin papillomas that progressed to carcinoma, whereas wild-type mice did not develop tumors. We confirmed that CXCR2 is expressed by keratinocytes and showed that transformation by oncogenic ras (a hallmark of DMBA initiation) or TPA exposure induced all CXCR2 ligands. Ras induction of CXCR2 ligands was mediated by autocrine activation of epidermal growth factor receptor and nuclear factor-kappaB, and potentiated by PKCalpha. Oncogenic ras also induced CXCR2 ligands in keratinocytes genetically ablated for CXCR2. However, ras transformed CXCR2 null keratinocytes formed only small skin tumors in orthotopic skin grafts to CXCR2 intact hosts, whereas transformed wild-type keratinocytes produced large tumors. In vitro, CXCR2 was essential for CXCR2 ligand-stimulated migration of ras-transformed keratinocytes and for ligand activation of the extracellular signal-regulated kinase (ERK) and Akt pathways. Both migration and activation of ERK and Akt were restored by CXCR2 reconstitution of CXCR2 null keratinocytes. Thus, activation of CXCR2 on ras-transformed keratinocytes has both promigratory and protumorigenic functions. The up-regulation of CXCR2 ligands after initiation by oncogenic ras and promotion with TPA in the mouse skin model provides a mechanism to stimulate migration by both autocrine and paracrine pathways and contribute to tumor development. JF - Cancer research AU - Cataisson, Christophe AU - Ohman, Rebecca AU - Patel, Gopal AU - Pearson, Andrea AU - Tsien, Margaret AU - Jay, Steve AU - Wright, Lisa AU - Hennings, Henry AU - Yuspa, Stuart H AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute/NIH, 37 Convent Drive, Bethesda, MD 20892-4264, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 319 EP - 328 VL - 69 IS - 1 KW - Ligands KW - 0 KW - Receptors, Interleukin-8B KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Protein Kinase C-alpha KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Neutrophils -- pathology KW - Enzyme Activation KW - HeLa Cells KW - Humans KW - Mice KW - Protein Kinase C-alpha -- metabolism KW - Hair Follicle -- enzymology KW - Protein Kinase C-alpha -- biosynthesis KW - Drug Eruptions -- pathology KW - Female KW - Male KW - Skin Neoplasms -- enzymology KW - Cell Transformation, Neoplastic -- pathology KW - Keratinocytes -- enzymology KW - Cell Transformation, Neoplastic -- metabolism KW - Skin Neoplasms -- pathology KW - Keratinocytes -- pathology KW - Keratinocytes -- metabolism KW - Skin Neoplasms -- metabolism KW - Receptors, Interleukin-8B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66781886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Inducible+cutaneous+inflammation+reveals+a+protumorigenic+role+for+keratinocyte+CXCR2+in+skin+carcinogenesis.&rft.au=Cataisson%2C+Christophe%3BOhman%2C+Rebecca%3BPatel%2C+Gopal%3BPearson%2C+Andrea%3BTsien%2C+Margaret%3BJay%2C+Steve%3BWright%2C+Lisa%3BHennings%2C+Henry%3BYuspa%2C+Stuart+H&rft.aulast=Cataisson&rft.aufirst=Christophe&rft.date=2009-01-01&rft.volume=69&rft.issue=1&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-2490 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-30 N1 - Date created - 2009-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1995 May 1;55(9):1883-93 [7728756] J Immunol. 2003 Sep 1;171(5):2703-13 [12928424] Cancer Res. 1997 Aug 1;57(15):3180-8 [9242447] Mol Carcinog. 1997 Sep;20(1):151-8 [9328446] J Biol Chem. 1998 Apr 24;273(17):10095-8 [9553055] J Dermatol Sci. 1998 May;17(1):1-7 [9651822] Genes Dev. 1999 Jun 1;13(11):1382-97 [10364156] Nat Med. 1999 Jul;5(7):828-31 [10395330] J Cell Sci. 1999 Oct;112 ( Pt 20):3497-506 [10504298] Oncol Rep. 1999 Nov-Dec;6(6):1405-10 [10523720] Cancer Res. 2004 Nov 1;64(21):7801-12 [15520186] Cancer Cell. 2004 Nov;6(5):447-58 [15542429] Semin Cancer Biol. 2005 Apr;15(2):75-83 [15652452] J Immunol. 2005 Feb 1;174(3):1686-92 [15661932] Adv Cancer Res. 2005;93:159-87 [15797447] J Immunol. 2005 Apr 15;174(8):5047-56 [15814736] Cancer Cell. 2005 May;7(5):411-23 [15894262] Cancer Immunol Immunother. 2006 Mar;55(3):237-45 [16047143] Nat Rev Cancer. 2006 Jan;6(1):24-37 [16397525] Eur J Cancer. 2006 Apr;42(6):735-44 [16527478] Cancer Res. 2006 Apr 15;66(8):4279-84 [16618752] Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12493-8 [16891410] J Clin Invest. 2006 Oct;116(10):2757-66 [16964312] J Biol Chem. 2006 Nov 24;281(47):35931-41 [16990258] J Cell Sci. 2007 Aug 15;120(Pt 16):2851-63 [17666434] Cancer Cell. 2008 Jan;13(1):23-35 [18167337] Neoplasia. 2008 Feb;10(2):131-9 [18283335] Nat Protoc. 2008;3(5):799-810 [18451788] J Biol Chem. 2008 Sep 26;283(39):26538-47 [18662984] J Exp Med. 2003 Sep 1;198(5):747-55 [12953094] J Immunol. 2004 Mar 1;172(5):2853-60 [14978086] Oncogene. 2004 Mar 11;23(10):1902-10 [14661063] J Cell Sci. 2004 Nov 1;117(Pt 23):5489-96 [15479720] Nature. 1986 Oct 30-Nov 5;323(6091):822-4 [2430189] J Cell Biol. 1989 Sep;109(3):1207-17 [2475508] Mol Carcinog. 1991;4(3):196-202 [2064725] Mol Carcinog. 1991;4(3):210-9 [2064727] Carcinogenesis. 1993 Nov;14(11):2353-8 [8242866] J Exp Med. 1995 Jan 1;181(1):435-40 [7807024] Cancer Res. 2000 Jan 15;60(2):226-9 [10667563] J Biol Chem. 2000 Mar 10;275(10):6868-75 [10702246] J Invest Dermatol. 2000 May;114(5):976-83 [10771480] Cancer Res. 2000 Jul 1;60(13):3328-32 [10910032] Oncogene. 2000 Jul 20;19(31):3477-86 [10918606] J Invest Dermatol. 2000 Aug;115(2):234-44 [10951241] Cytokine. 2001 Jun 7;14(5):253-63 [11444905] Int J Cancer. 2001 Sep 1;93(5):635-43 [11477572] Nature. 2003 Feb 6;421(6923):639-43 [12571598] Am J Pathol. 2003 Jul;163(1):303-12 [12819035] Science. 1995 Jul 14;269(5221):230-4 [7618084] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-2490 ER - TY - JOUR T1 - When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. AN - 66751231; 19001870 AB - The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, which results from a deficiency of the glycogen-degrading lysosomal hydrolase acid-alpha glucosidase (GAA). Skeletal and cardiac muscle are most severely affected by the progressive expansion of glycogen-filled lysosomes. In both humans and an animal model of the disease (GAA KO), skeletal muscle pathology also involves massive accumulation of autophagic vesicles and autophagic buildup in the core of myofibers, suggesting an induction of autophagy. Only when we suppressed autophagy in the skeletal muscle of the GAA KO mice did we realize that the excess of autophagy manifests as a functional deficiency. This failure of productive autophagy is responsible for the accumulation of potentially toxic aggregate-prone ubiquitinated proteins, which likely cause profound muscle damage in Pompe mice. Also, by generating muscle-specific autophagy-deficient wild-type mice, we were able to analyze the role of autophagy in healthy skeletal muscle. JF - Autophagy AU - Raben, Nina AU - Baum, Rebecca AU - Schreiner, Cynthia AU - Takikita, Shoichi AU - Mizushima, Noboru AU - Ralston, Evelyn AU - Plotz, Paul AD - Arthritis and Rheumatism Branch, NIAMS, NIH, Bethesda, MD 20892-1820, USA. rabenn@arb.niams.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 111 EP - 113 VL - 5 IS - 1 KW - alpha-Glucosidases KW - EC 3.2.1.20 KW - Index Medicus KW - Animals KW - Humans KW - alpha-Glucosidases -- metabolism KW - Organ Specificity KW - Mice KW - alpha-Glucosidases -- deficiency KW - Mice, Knockout KW - Muscle, Skeletal -- pathology KW - Muscle, Skeletal -- ultrastructure KW - Autophagy KW - Glycogen Storage Disease Type II -- enzymology KW - Muscle, Skeletal -- enzymology KW - Glycogen Storage Disease Type II -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66751231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autophagy&rft.atitle=When+more+is+less%3A+excess+and+deficiency+of+autophagy+coexist+in+skeletal+muscle+in+Pompe+disease.&rft.au=Raben%2C+Nina%3BBaum%2C+Rebecca%3BSchreiner%2C+Cynthia%3BTakikita%2C+Shoichi%3BMizushima%2C+Noboru%3BRalston%2C+Evelyn%3BPlotz%2C+Paul&rft.aulast=Raben&rft.aufirst=Nina&rft.date=2009-01-01&rft.volume=5&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Autophagy&rft.issn=1554-8635&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-12-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2000 Nov 1;19(21):5720-8 [11060023] Cell Struct Funct. 2002 Dec;27(6):421-9 [12576635] Dev Cell. 2004 Apr;6(4):463-77 [15068787] J Cell Biol. 1972 Jan;52(1):41-51 [4331300] Mol Ther. 2005 Jan;11(1):48-56 [15585405] J Cell Biol. 2005 May 9;169(3):425-34 [15866887] Ann Neurol. 2006 Apr;59(4):700-8 [16532490] Nature. 2006 Jun 15;441(7095):885-9 [16625204] Nature. 2006 Jun 15;441(7095):880-4 [16625205] Autophagy. 2005 Jul;1(2):84-91 [16874052] Pathol Res Pract. 2006;202(9):631-8 [16781826] Autophagy. 2006 Oct-Dec;2(4):318-20 [16874053] Mol Ther. 2006 Dec;14(6):831-9 [17008131] Curr Neurol Neurosci Rep. 2007 Jan;7(1):71-7 [17217857] Autophagy. 2007 Jul-Aug;3(4):323-8 [17387262] J Biol Chem. 2007 Aug 17;282(33):24131-45 [17580304] Autophagy. 2007 Nov-Dec;3(6):546-52 [17592248] Autophagy. 2007 Nov-Dec;3(6):542-5 [17611390] Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7 [17712358] Autophagy. 2008 Feb;4(2):151-75 [18188003] Nature. 2008 Feb 28;451(7182):1069-75 [18305538] Autophagy. 2008 Jul;4(5):727-30 [18437051] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction. AN - 66748479; 19096789 AB - Irradiation damage to salivary glands is a common iatrogenic consequence of treatment for head and neck cancers. The subsequent lack of saliva production leads to many functional and quality-of-life problems for affected patients and there is no effective conventional therapy. To address this problem, we developed an in vivo gene therapy strategy involving viral vector-mediated transfer of the aquaporin-1 cDNA to irradiation-damaged glands and successfully tested it in two pre-clinical models (irradiated rats and miniature pigs), as well as demonstrated its safety in a large toxicology and biodistribution study. Thereafter, a clinical research protocol was developed that has received approval from all required authorities in the United States. Patients are currently being enrolled in this study. JF - Handbook of experimental pharmacology AU - Baum, Bruce J AU - Zheng, Changyu AU - Cotrim, Ana P AU - McCullagh, Linda AU - Goldsmith, Corinne M AU - Brahim, Jaime S AU - Atkinson, Jane C AU - Turner, R James AU - Liu, Shuying AU - Nikolov, Nikolay AU - Illei, Gabor G AD - Molecular Physiology and Therapeutics Branch and Clinical Research Core, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA. bbaum@dir.nidcr.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 403 EP - 418 IS - 190 SN - 0171-2004, 0171-2004 KW - AQP1 protein, human KW - 0 KW - Aquaporin 1 KW - 146410-94-8 KW - Index Medicus KW - Animals KW - Humans KW - Genetic Vectors KW - Clinical Trials as Topic KW - Disease Models, Animal KW - Research Design KW - Cell Line KW - Radiotherapy -- adverse effects KW - Adenoviridae -- genetics KW - Radiation Injuries -- genetics KW - Aquaporin 1 -- biosynthesis KW - Gene Transfer Techniques -- adverse effects KW - Xerostomia -- metabolism KW - Xerostomia -- therapy KW - Radiation Injuries -- metabolism KW - Xerostomia -- etiology KW - Salivary Glands -- radiation effects KW - Xerostomia -- genetics KW - Aquaporin 1 -- genetics KW - Genetic Therapy -- adverse effects KW - Radiation Injuries -- therapy KW - Genetic Therapy -- methods KW - Salivary Glands -- metabolism KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66748479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Aquaporin-1+gene+transfer+to+correct+radiation-induced+salivary+hypofunction.&rft.au=Baum%2C+Bruce+J%3BZheng%2C+Changyu%3BCotrim%2C+Ana+P%3BMcCullagh%2C+Linda%3BGoldsmith%2C+Corinne+M%3BBrahim%2C+Jaime+S%3BAtkinson%2C+Jane+C%3BTurner%2C+R+James%3BLiu%2C+Shuying%3BNikolov%2C+Nikolay%3BIllei%2C+Gabor+G&rft.aulast=Baum&rft.aufirst=Bruce&rft.date=2009-01-01&rft.volume=&rft.issue=190&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-79885-9_20 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3268-73 [9096382] Hum Gene Ther. 1996 Jun 10;7(9):1085-93 [8773510] Arch Oral Biol. 1998 Apr;43(4):297-303 [9839705] Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1510-6 [16029813] Ann N Y Acad Sci. 1999 Jun 18;875:294-300 [10415576] Radiat Res. 1999 Feb;151(2):150-8 [9952299] Hum Gene Ther. 2006 Nov;17(11):1122-33 [17069536] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103 Suppl:S66.e1-19 [17379158] Mol Ther. 2005 Mar;11(3):444-51 [15727941] Cancer Gene Ther. 1999 Nov-Dec;6(6):505-13 [10608347] Hum Gene Ther. 2002 Jan 1;13(1):15-63 [11779412] Int Rev Cytol. 2002;213:93-146 [11837896] Oral Dis. 2002 Jul;8(4):183-91 [12206399] Arch Otolaryngol Head Neck Surg. 2003 Feb;129(2):247-50 [12578459] Crit Rev Oral Biol Med. 2003;14(3):199-212 [12799323] Mol Genet Metab. 2003 Sep-Oct;80(1-2):148-58 [14567964] J Gene Med. 2004 Jan;6(1):55-63 [14716677] Ann N Y Acad Sci. 1993 Sep 20;694:17-23 [8105741] Am J Physiol. 1994 Jun;266(6 Pt 1):G1146-55 [8023944] Biochem Biophys Res Commun. 1998 May 29;246(3):584-8 [9618254] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/978-3-540-79885-9_20 ER - TY - JOUR T1 - A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells. AN - 66748438; 18996183 AB - Organisms exposed to ionizing radiation are mainly damaged by free radicals, which are generated by the radiolysis of water contained in the cells. Recently a significant reduction of tissue injury from irradiation damage was demonstrated by using MnSOD-plasmid/liposome treatments in the protection of murine lung. In this study we show that a new active recombinant human MnSOD (rMnSOD), easily administered in vivo, not only exerts the same radioprotective effect on normal cells and organisms as any MnSOD, but it is also radiosensitizing for tumor cells. In addition, we show how healthy animals, exposed to lethal doses of ionizing radiation and daily injections with rMnSOD, were protected from radiodamage and were still alive 30 days after the irradiation, while animals treated with only PBS solution, in the absence of rMnSOD, died after 7-8 days from the radiotreatments. The molecular analysis of all irradiated tissues revealed that the antiapoptotic AVEN gene appeared activated only in the animals treated in the presence of rMnSOD. The data suggest that rMnSOD deserves to be considered as a pharmaceutical tool for making radiotherapy more selective on cancer cells and to prevent and/or cure the accidental damage derived from exposure to ionizing radiation. JF - Free radical biology & medicine AU - Borrelli, Antonella AU - Schiattarella, Antonella AU - Mancini, Roberto AU - Morrica, Brunello AU - Cerciello, Vincenzo AU - Mormile, Maria AU - d'Alesio, Valentina AU - Bottalico, Laura AU - Morelli, Francesco AU - D'Armiento, Maria AU - D'Armiento, Francesco Paolo AU - Mancini, Aldo AD - Department of Molecular Biology and Biotherapy, National Cancer Institute of Naples, Italy. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 110 EP - 116 VL - 46 IS - 1 KW - AVEN protein, human KW - 0 KW - Adaptor Proteins, Signal Transducing KW - Apoptosis Regulatory Proteins KW - Free Radical Scavengers KW - Free Radicals KW - Membrane Proteins KW - Radiation-Sensitizing Agents KW - Recombinant Proteins KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - Free Radicals -- toxicity KW - Gene Expression -- drug effects KW - Neoplasms -- drug therapy KW - Animals KW - Radiation Injuries -- prevention & control KW - Humans KW - Apoptosis -- radiation effects KW - Cell Line, Tumor KW - Mice KW - Radiation Tolerance -- drug effects KW - Radiation-Sensitizing Agents -- therapeutic use KW - Neoplasms -- radiotherapy KW - Apoptosis -- drug effects KW - Lethal Dose 50 KW - Mice, Inbred C57BL KW - Female KW - Gene Expression -- radiation effects KW - Radiation, Ionizing KW - Fibroblasts -- drug effects KW - Recombinant Proteins -- pharmacology KW - Apoptosis Regulatory Proteins -- genetics KW - Superoxide Dismutase -- administration & dosage KW - Free Radical Scavengers -- administration & dosage KW - Adaptor Proteins, Signal Transducing -- biosynthesis KW - Apoptosis Regulatory Proteins -- radiation effects KW - Superoxide Dismutase -- pharmacology KW - Fibroblasts -- pathology KW - Apoptosis Regulatory Proteins -- metabolism KW - Membrane Proteins -- biosynthesis KW - Apoptosis Regulatory Proteins -- biosynthesis KW - Fibroblasts -- radiation effects KW - Free Radical Scavengers -- pharmacology KW - Recombinant Proteins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66748438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=A+recombinant+MnSOD+is+radioprotective+for+normal+cells+and+radiosensitizing+for+tumor+cells.&rft.au=Borrelli%2C+Antonella%3BSchiattarella%2C+Antonella%3BMancini%2C+Roberto%3BMorrica%2C+Brunello%3BCerciello%2C+Vincenzo%3BMormile%2C+Maria%3Bd%27Alesio%2C+Valentina%3BBottalico%2C+Laura%3BMorelli%2C+Francesco%3BD%27Armiento%2C+Maria%3BD%27Armiento%2C+Francesco+Paolo%3BMancini%2C+Aldo&rft.aulast=Borrelli&rft.aufirst=Antonella&rft.date=2009-01-01&rft.volume=46&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.10.030 ER - TY - JOUR T1 - Transitions in and out of alcohol use disorders: their associations with conditional changes in quality of life over a 3-year follow-up interval. AN - 66740000; 19042925 AB - The aim of this study was to investigate longitudinal changes in quality of life (QOL) as a function of transitions in alcohol use disorders (AUD) over a 3-year follow-up of a general US population sample. The analysis is based on individuals who drank alcohol in the year preceding the Wave 1 National Epidemiologic Survey on Alcohol and Related Conditions and were reinterviewed at Wave 2 (n = 22,245). Using multiple linear regression models, changes in SF-12 QOL were estimated as a function of DSM-IV AUD transitions, controlling for baseline QOL and multiple potential confounders. Onset and offset of AUD were strongly associated with changes in mental/psychological functioning, with significant decreases in mental component summary (NBMCS) scores among individuals who developed dependence and significant increases among those who achieved full and partial remission from dependence. The increases in overall NBMCS and its social functioning, role emotional and mental health components were equally great for abstinent and nonabstinent remission from dependence, but improvements in bodily pain and general health were associated with nonabstinent remission only. Onset of abuse was unrelated to changes in QOL, and the increase in NBMCS associated with nonabstinent remission from abuse only was slight. Individuals with abuse only or no AUD who stopped drinking had significant declines in QOL. These results suggest the possible importance of preventing and treating AUD for maintaining and/or improving QOL. They are also consistent with the sick quitter hypothesis and suggest that abuse is less a mental disorder than a maladaptive pattern of behavior. JF - Alcohol and alcoholism (Oxford, Oxfordshire) AU - Dawson, Deborah A AU - Li, Ting-Kai AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Biometry and Epidemiology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. ddawson@mail.nih.gov PY - 2009 SP - 84 EP - 92 VL - 44 IS - 1 KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Pain -- psychology KW - Health Status KW - Linear Models KW - Models, Statistical KW - Longitudinal Studies KW - Pain -- complications KW - Psychiatric Status Rating Scales KW - Adult KW - Health Surveys KW - Follow-Up Studies KW - Temperance KW - Adolescent KW - Female KW - Male KW - Alcoholism -- epidemiology KW - Quality of Life KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66740000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.atitle=Transitions+in+and+out+of+alcohol+use+disorders%3A+their+associations+with+conditional+changes+in+quality+of+life+over+a+3-year+follow-up+interval.&rft.au=Dawson%2C+Deborah+A%3BLi%2C+Ting-Kai%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2009-01-01&rft.volume=44&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.issn=1464-3502&rft_id=info:doi/10.1093%2Falcalc%2Fagn094 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1995 Nov 15;274(19):1511-7 [7474219] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Alcohol Clin Exp Res. 1997 Aug;21(5):899-905 [9267541] Alcohol Alcohol. 1997 Jul-Aug;32(4):527-35 [9269861] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] J Subst Abuse. 1998;10(1):75-84 [9720008] Am J Drug Alcohol Abuse. 1998 Nov;24(4):685-94 [9849778] Am J Addict. 1999 Winter;8(1):44-54 [10189514] Alcohol Alcohol. 1999 Mar-Apr;34(2):183-92 [10344779] J Neurosurg. 2005 Mar;102(3):489-94 [15796384] Lancet. 2005 Feb 5-11;365(9458):519-30 [15705462] J Stud Alcohol. 1999 Sep;60(5):653-62 [10487735] J Stud Alcohol Suppl. 2005 Jul;(15):119-39; discussion 92-3 [16223064] J Ambul Care Manage. 2006 Jan-Mar;29(1):61-70 [16340620] Spine (Phila Pa 1976). 2006 Mar 15;31(6):639-43 [16540866] Drug Alcohol Rev. 2006 Nov;25(6):503-13 [17132570] J Stud Alcohol Drugs. 2007 Jan;68(1):36-47 [17149516] Addiction. 2007 Feb;102(2):257-63 [17222280] Ann Epidemiol. 2007 May;17(5 Suppl):S16-23 [17478320] Drug Alcohol Depend. 2008 Jan 1;92(1-3):27-36 [17706375] J Stud Alcohol Drugs. 2008 Nov;69(6):866-77 [18925345] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] Addiction. 1999 Jun;94(6):843-55 [10665074] Med Care. 2000 Nov;38(11):1141-50 [11078054] J Nurs Meas. 2001 Fall;9(2):151-61 [11696939] J Gen Intern Med. 2002 May;17(5):382-6 [12047737] J Stud Alcohol. 2002 Jul;63(4):397-403 [12160097] Ophthalmology. 2002 Oct;109(10):1793-8 [12359596] Am J Drug Alcohol Abuse. 2003 May;29(2):323-35 [12765209] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Am J Addict. 2003 May-Jun;12(3):198-210 [12851016] Alcohol Clin Exp Res. 2004 Jan;28(1):64-77 [14745303] Int J Rehabil Res. 2004 Jun;27(2):149-50 [15167113] Drug Alcohol Depend. 2004 Jun 11;74(3):223-34 [15194200] Aust N Z J Psychiatry. 2004 Oct;38(10):842-8 [15369544] Lancet. 1988 Dec 3;2(8623):1267-73 [2904004] Addiction. 1993 Aug;88(8):1079-90 [8401162] J Consult Clin Psychol. 1995 Feb;63(1):133-40 [7896978] Alcohol Alcohol. 1996 Nov;31(6):565-76 [9010547] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/alcalc/agn094 ER - TY - JOUR T1 - Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal. AN - 66736892; 18723835 AB - The mechanism by which chronic ethanol consumption reduces concentrations of long chain polyunsaturated (LCP) fatty acids (FA) in tissues of humans was investigated in alcohol-dependent (AD) men during early withdrawal and to a well-matched control group by fitting the concentration-time curves of d(5)-labeled n-3 FA from plasma and liver, which originated from an oral dose of d(5)-linolenic acid (d(5)-18:3n-3) ethyl ester to a compartmental model. Blood sampled over 168 h and a liver specimen obtained 96 h after isotope administration were analyzed for d(5)-18:3n-3, d(5)-20:5n-3, d(5)-22:5n-3, and d(5)-22:6n-3. Plasma 20:5n-3 and 22:5n-3 were lower in AD subjects, compared with controls (20:5n-3: -50%, 22:5n-3: -34%). Increased amounts of d(5)-18:3n-3 were directed toward synthesis of d(5)-20:5n-3 in AD subjects (P < .05). However, this effect was offset by larger amounts of 20:5n-3 lost from plasma (control: 2.0 vs. AD: 4.2 mg d(-1)). In livers of AD subjects, more d(5)-18:3n-3 and d(5)-22:5n-3 were utilized for synthesis of d(5)-20:5n-3 (+200%) and d(5)-22:6n-3 (+210%), respectively, than was predicted from plasma kinetics. Although, the potential to utilize linolenic acid for synthesis of LCP FA was greater in AD subjects compared with controls, heightened disappearance rates of 20:5n-3 reduced overall plasma concentrations of several endogenous n-3 LCP FA. JF - Journal of lipid research AU - Pawlosky, Robert J AU - Hibbeln, Joseph R AU - Herion, David AU - Kleiner, David E AU - Salem, Norman AD - Laboratory of Metabolic Control, National Cancer Institute NIH, Bethesda, MD, USA. bpawl@niaaa.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 154 EP - 161 VL - 50 IS - 1 SN - 0022-2275, 0022-2275 KW - Fatty Acids, Essential KW - 0 KW - Fatty Acids, Omega-3 KW - alpha-Linolenic Acid KW - 0RBV727H71 KW - Index Medicus KW - alpha-Linolenic Acid -- metabolism KW - Mass Spectrometry KW - Substance Withdrawal Syndrome -- metabolism KW - Area Under Curve KW - Humans KW - Adult KW - Biopsy KW - Substance Withdrawal Syndrome -- blood KW - Time Factors KW - Models, Biological KW - Male KW - Hepatocytes -- metabolism KW - Liver -- pathology KW - Fatty Acids, Omega-3 -- metabolism KW - Fatty Acids, Essential -- blood KW - Liver -- metabolism KW - Alcoholism -- metabolism KW - Fatty Acids, Essential -- metabolism KW - Fatty Acids, Omega-3 -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66736892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Compartmental+analysis+of+plasma+and+liver+n-3+essential+fatty+acids+in+alcohol-dependent+men+during+withdrawal.&rft.au=Pawlosky%2C+Robert+J%3BHibbeln%2C+Joseph+R%3BHerion%2C+David%3BKleiner%2C+David+E%3BSalem%2C+Norman&rft.aulast=Pawlosky&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=00222275&rft_id=info:doi/10.1194%2Fjlr.M800322-JLR200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-02 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1999 Sep;104(6):805-13 [10491416] Alcohol Clin Exp Res. 1999 Feb;23(2):311-7 [10069561] Hepatology. 2005 Jun;41(6):1313-21 [15915461] Alcohol Clin Exp Res. 2001 Aug;25(8):1231-7 [11505055] J Lipid Res. 2001 Aug;42(8):1257-65 [11483627] J Lipid Res. 2007 Apr;48(4):935-43 [17234605] Alcohol Clin Exp Res. 2001 Dec;25(12):1758-65 [11781509] Br J Nutr. 2002 Oct;88(4):355-63 [12323085] Biol Psychiatry. 2003 Mar 1;53(5):431-41 [12614996] Br J Nutr. 2003 Nov;90(5):993-4; discussion 994-5 [14667193] Fed Proc. 1972 Sep-Oct;31(5):1451-7 [5056171] Biol Psychiatry. 1978 Oct;13(5):551-65 [728507] Lipids. 1980 Apr;15(4):263-8 [7374380] Alcohol Clin Exp Res. 1983 Spring;7(2):220-6 [6408939] Alcohol Clin Exp Res. 1983 Fall;7(4):424-30 [6419631] Ann Nutr Metab. 1985;29(4):246-52 [4026205] J Lipid Res. 1985 Jul;26(7):806-18 [4040952] Eur J Clin Nutr. 1988 Sep;42(9):797-803 [2846266] Biomed Chromatogr. 1990 Nov;4(6):234-8 [2289046] Alcohol Alcohol. 1991;26(4):459-64 [1760057] Free Radic Biol Med. 1992;12(3):219-40 [1563648] J Intern Med. 1992 Apr;231(4):349-56 [1588258] J Am Coll Nutr. 1992 Jun;11(3):304-8 [1619182] Arch Gen Psychiatry. 1992 Aug;49(8):630-6 [1637253] Hepatology. 1992 Aug;16(2):448-53 [1639354] Am J Clin Nutr. 1992 Sep;56(3):467-74 [1503056] J Lipid Res. 1992 Nov;33(11):1711-7 [1464754] Alcohol Alcohol. 1993 May;28(3):287-95 [8352840] Gastroenterology. 1994 Jan;106(1):152-9 [8276177] J Clin Invest. 1994 Jan;93(1):450-4 [8282819] Hepatology. 1994 May;19(5):1229-40 [8175146] Alcohol Alcohol. 1994 Sep;29(5):493-502 [7811333] N Engl J Med. 1995 May 4;332(18):1198-203 [7700313] Am J Clin Nutr. 1995 Jun;61(6):1284-9 [7762532] Hepatology. 1996 Apr;23(4):872-80 [8666344] Circulation. 1996 Jul 1;94(1):19-25 [8964113] Am J Epidemiol. 1996 Aug 15;144(4):325-34 [8712189] J Biol Chem. 1999 Jan 1;274(1):471-7 [9867867] Alcohol. 2004 Aug;34(1):27-33 [15670662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1194/jlr.M800322-JLR200 ER - TY - JOUR T1 - Less is more, except when less is less: Studying joint effects. AN - 66734312; 18598750 AB - Most diseases are complex in that they are caused by the joint action of multiple factors, both genetic and environmental. Over the past few decades, the mathematical convenience of logistic regression has served to enshrine the multiplicative model, to the point where many epidemiologists believe that departure from additivity on a log scale implies that two factors interact in causing disease. Other terminology in epidemiology, where students are told that inequality of relative risks across levels of a second factor should be seen as "effect modification," reinforces an uncritical acceptance of multiplicative joint effect as the biologically meaningful no-interaction null. Our first task, when studying joint effects, is to understand the limitations of our definitions for "interaction," and recognize that what statisticians mean and what biologists might want to mean by interaction may not coincide. Joint effects are notoriously hard to identify and characterize, even when asking a simple and unsatisfying question, like whether two effects are log-additive. The rule of thumb for such efforts is that a factor-of-four sample size is needed, compared with that needed to demonstrate main effects of either genes or exposures. So strategies have been devised that focus on the most informative individuals, either through risk-based sampling for a cohort, or case-control sampling, extreme phenotype sampling, pooling, two-stage sampling, exposed-only, or case-only designs. These designs gain efficiency, but at a cost of flexibility in models for joint effects. A relatively new approach avoids population controls by genotyping case-parent triads. Because it requires parents, the method works best for diseases with onset early in life. With this design, the role of autosomal genetic variants is assessed by in effect treating the nontransmitted parental alleles as controls for affected offspring. Despite advantages for looking at genetic effects, the triad design faces limitations when examining joint effects of genetic and environmental factors. Because population-based controls are not included, main effects for exposures cannot be estimated, and consequently one only has access to inference related to a multiplicative null. We have proposed a hybrid approach that offers the best features of both case-parent and case-control designs. Through genotyping of parents of population-based controls and assuming Mendelian transmission, power is markedly enhanced. One can also estimate main effects for exposures and now flexibly assess models for joint effects. JF - Genomics AU - Weinberg, C R AD - National Institute of Environmental Health Sciences, MD A3-03, P.O. Box 12233, Research Triangle Park, NC 27709, USA. weinber2@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 10 EP - 12 VL - 93 IS - 1 KW - Index Medicus KW - Genotype KW - Epidemiologic Methods KW - Humans KW - Case-Control Studies KW - Parents KW - Research Design KW - Models, Genetic KW - Environmental Exposure KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66734312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Less+is+more%2C+except+when+less+is+less%3A+Studying+joint+effects.&rft.au=Weinberg%2C+C+R&rft.aulast=Weinberg&rft.aufirst=C&rft.date=2009-01-01&rft.volume=93&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=1089-8646&rft_id=info:doi/10.1016%2Fj.ygeno.2008.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biometrics. 1999 Sep;55(3):718-26 [11314998] Eur J Hum Genet. 2004 Nov;12(11):964-70 [15340361] Am J Epidemiol. 1982 Jan;115(1):119-28 [7055123] Am J Epidemiol. 1986 Jan;123(1):162-73 [3940436] Am J Hum Genet. 1993 Mar;52(3):506-16 [8447318] Stat Med. 1994 Jan 30;13(2):153-62 [8122051] Am J Hum Genet. 1998 Apr;62(4):969-78 [9529360] Am J Epidemiol. 1998 Nov 1;148(9):893-901 [9801020] Am J Hum Genet. 1999 Jul;65(1):229-35 [10364536] Am J Hum Genet. 2005 Oct;77(4):627-36 [16175508] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ygeno.2008.06.002 ER - TY - JOUR T1 - Age at menarche and weight concerns in relation to smoking trajectory and dependence among adolescent girls enrolled in a smoking cessation trial. AN - 66724378; 18940275 AB - Many girls adopt dieting and other practices (i.e. cigarette smoking) to control weight during puberty. This analysis explored the relationship between age at menarche and onset of daily smoking, and whether this relationship was influenced by weight concerns among treatment seeking female adolescents. The sample consisted of 71 participants enrolled in a smoking cessation trial (age 15.2+/-1.3 years; 74.7% European American, baseline BMI 24.7+/-5.4, age at menarche 11.7+/-1.3 years, Fagerström Test for Nicotine Dependence score 7.0+/-1.2). Over 60% of participants reported weight concerns at baseline, based on responses to the Eating Disorders module from the Diagnostic Interview for Children and Adolescents. Linear regression analyses revealed a significant association between age at menarche and age of onset of daily smoking (beta=0.18+/-0.09, p=0.038). Having weight concerns did not modify the relationships between age at menarche and smoking trajectory/severity or abstinence. Findings support previous research showing that early maturation represents a risk factor for substance use. Further study in larger samples that include non-treatment-seeking adolescent female smokers is warranted. JF - Addictive behaviors AU - Jaszyna-Gasior, Maria AU - Schroeder, Jennifer R AU - Thorner, Elissa D AU - Heishman, Stephen J AU - Collins, Charles C AU - Lo, Suzanne AU - Moolchan, Eric T AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Biomedical Research Center, Baltimore, Maryland 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 92 EP - 95 VL - 34 IS - 1 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Nicotine -- therapeutic use KW - Nicotinic Agonists -- therapeutic use KW - Humans KW - Child KW - Adolescent KW - Female KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- drug therapy KW - Body Weight -- drug effects KW - Menarche -- physiology KW - Feeding and Eating Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66724378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Age+at+menarche+and+weight+concerns+in+relation+to+smoking+trajectory+and+dependence+among+adolescent+girls+enrolled+in+a+smoking+cessation+trial.&rft.au=Jaszyna-Gasior%2C+Maria%3BSchroeder%2C+Jennifer+R%3BThorner%2C+Elissa+D%3BHeishman%2C+Stephen+J%3BCollins%2C+Charles+C%3BLo%2C+Suzanne%3BMoolchan%2C+Eric+T&rft.aulast=Jaszyna-Gasior&rft.aufirst=Maria&rft.date=2009-01-01&rft.volume=34&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=1873-6327&rft_id=info:doi/10.1016%2Fj.addbeh.2008.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-30 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addbeh.2008.08.001 ER - TY - JOUR T1 - Effect of indoor air pollution from biomass fuel use on argyrophilic nuclear organizer regions in buccal epithelial cells. AN - 66635939; 19888913 AB - This study investigated the effect of indoor air pollution from biomass-fuel use on the expression of argyrophilic nucleolar organizer regions (AgNORs), an indicator of ribosome biosynthesis, in epithelial cells of oral mucosa. AgNORs were evaluated using cytochemical staining in 62 nonsmoking indian women (median age, 34 years), who cooked exclusively with biomass, and 55 age-matched women, who were from a similar neighborhood and cooked with relatively clean liquefied petroleum gas (LPG). Concentrations of particulate pollutants in indoor air were measured using a real-time aerosol monitor. Compared to the LPG-using controls, biomass-fuel users showed a remarkably increased number of AgNOR dots per nucleus (6.08 +/-2.26 vs 3.16 +/-0.86, p < 0.001), AgNOR size (0.85 +/-0.19 vs 0.53 +/-0.15 mum2, p < 0.001), and percentage of AgNOR-occupied nuclear area (4.88 +/-1.49 vs 1.75 +/-0.13%, p < 0.001). Biomass-using households had 2 to 4 times more particulate pollutants than that of LPG-using households. The changes in AgNOR expression were positively associated with PM10 and PM2.5 levels in indoor air after controlling for potential confounders such as age, kitchen location, and family income. Thus, biomass smoke appears to be a risk factor for abnormal cell growth via upregulation of ribosome biogenesis. JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer AU - Mondal, Nandan K AU - Dutta, Anindita AU - Banerjee, Anirban AU - Chakraborty, Sreeparna AU - Lahiri, Twisha AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2009 PY - 2009 DA - 2009 SP - 253 EP - 259 VL - 28 IS - 3 KW - Air Pollutants KW - 0 KW - Antigens, Nuclear KW - Smoke KW - nucleolar organizer region associated proteins KW - Index Medicus KW - Humans KW - Cooking KW - Adult KW - Silver Staining KW - Energy-Generating Resources KW - Female KW - Smoke -- adverse effects KW - Air Pollution, Indoor -- adverse effects KW - Air Pollution, Indoor -- analysis KW - Mouth Mucosa -- pathology KW - Antigens, Nuclear -- drug effects KW - Biomass KW - Nucleolus Organizer Region -- drug effects KW - Air Pollutants -- adverse effects KW - Mouth Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66635939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.atitle=Effect+of+indoor+air+pollution+from+biomass+fuel+use+on+argyrophilic+nuclear+organizer+regions+in+buccal+epithelial+cells.&rft.au=Mondal%2C+Nandan+K%3BDutta%2C+Anindita%3BBanerjee%2C+Anirban%3BChakraborty%2C+Sreeparna%3BLahiri%2C+Twisha%3BRay%2C+Manas+Ranjan&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2009-01-01&rft.volume=28&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.issn=2162-6537&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Natural Language Processing Versus Content-Based Image Analysis for Medical Document Retrieval AN - 57727688; 200903843 AB - One of the most significant recent advances in health information systems has been the shift from paper to electronic documents. While research on automatic text and image processing has taken separate paths, there is a growing need for joint efforts, particularly for electronic health records and biomedical literature databases. This work aims at comparing text-based versus image-based access to multimodal medical documents using state-of-the-art methods of processing text and image components. A collection of 180 medical documents containing an image accompanied by a short text describing it was divided into training and test sets. Content-based image analysis and natural language processing techniques are applied individually and combine for multimodal document analysis. The evaluation consists of an indexing task and a retrieval task based on the "gold standard" codes manually assigned to corpus documents. The performance of text-based and image-based access, as well as combined document features, is compared. Image analysis proves more adequate for both the indexing and retrieval of the images. In the indexing task, multimodal analysis outperforms both independent image and text analysis. This experiment shows that text describing images can be usefully analyzed in the framework of a hybrid text/image retrieval system. [Copyright 2009 Wiley Periodicals Inc.] JF - Journal of the American Society for Information Science and Technology AU - Neveol, Aurelie AU - Deserno, Thomas M AU - Darmoni, Stefan J AU - Guld, Mark Oliver AU - Aronson, Alan R AD - U.S. National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894 neveola@nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 123 EP - 134 PB - Wiley Subscription Services, Hoboken NJ VL - 60 IS - 1 SN - 1532-2882, 1532-2882 KW - Natural language processing KW - Text processing KW - Images KW - article KW - 13.14: INFORMATION STORAGE AND RETRIEVAL - SEARCHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57727688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.atitle=Natural+Language+Processing+Versus+Content-Based+Image+Analysis+for+Medical+Document+Retrieval&rft.au=Neveol%2C+Aurelie%3BDeserno%2C+Thomas+M%3BDarmoni%2C+Stefan+J%3BGuld%2C+Mark+Oliver%3BAronson%2C+Alan+R&rft.aulast=Neveol&rft.aufirst=Aurelie&rft.date=2009-01-01&rft.volume=60&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.issn=15322882&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Natural language processing; Text processing; Images ER - TY - JOUR T1 - Mapping the Health Research Landscape in Sub-Saharan Africa: A Study of Trends in Biomedical Publications AN - 57708320; 200905040 AB - The process of research begins with grant-writing and concludes with publication. According to a recent study, in resource-poor settings, in-country national research and publications change clinical practice. One way to promote the visibility of these publications is for them to be peer reviewed and indexed in MEDLINE/PubMed. This process is fundamental not only to scientific progress, but to promoting the widespread communication of novel discoveries from low- and middle-income countries to the rest of the world. Worldwide scientific publishing activity over the past decade indicates that most countries in Sub-Saharan Africa (SSA) have low levels of publication. In a recent analysis, 31 of the world's 193 countries produce 97.5% of the world's most cited papers. South Africa, at number 29, is the only Sub-Saharan African country on this list, but little is known about the comparative volume of publications among the different countries in SSA. This study examined authorship in MEDLINE-indexed journal publications by Sub-Saharan African first authors as one metric of high-quality health research output. MEDLINE is the bibliographic database of the National Library of Medicine (NLM) at the US National Institutes of Health. Publication trends over a decade were tracked with two key objectives in mind: to approximate the research publishing landscape in the region, with special attention paid to country-specific (i.e., national) journals and to contrast the publication volume of the most productive country in SSA with publishing practices of other comparable countries outside the region. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Hofman, Karen J AU - Kanyengo, Christine W AU - Rapp, Barbara A AU - Kotzin, Sheldon AD - The John E. Fogarty International Center, National Institutes of Health, 16 Center Drive, MSC 6705, Bethesda, MD 20892-6705 hofmank@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 41 EP - 44 PB - Medical Library Association, Chicago, IL VL - 97 IS - 1 SN - 1536-5050, 1536-5050 KW - Bibliometrics KW - SubSaharan Africa KW - Scholarly publishing KW - Medicine KW - article KW - 16.16: PUBLISHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57708320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Mapping+the+Health+Research+Landscape+in+Sub-Saharan+Africa%3A+A+Study+of+Trends+in+Biomedical+Publications&rft.au=Hofman%2C+Karen+J%3BKanyengo%2C+Christine+W%3BRapp%2C+Barbara+A%3BKotzin%2C+Sheldon&rft.aulast=Hofman&rft.aufirst=Karen&rft.date=2009-01-01&rft.volume=97&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Scholarly publishing; Bibliometrics; Medicine; SubSaharan Africa ER - TY - JOUR T1 - OBESITY AND BODY MASS INDEX (BMI) IN RELATION TO LIFE-STYLE AND PSYCHO-SOCIAL ASPECTS AN - 57314511; 200928517 AB - Obesity is increasing in middle-aged adults and the elderly. This multifactorial phenomenon may have different causes, such as incorrect nutritional and dietary habits, psycho-social aspects and sedentary life-style. It is becoming a serious problem, due also to the world's ageing society. The aim of this study is to provide preliminary results on BMI, life-style and psycho-social aspects in a sample of Italian subjects, which also assesses the relationship between obesity and psychological health. We hypothesize that obesity is related to many factors, such as life-style, behavioral, socio-economic, and psychological aspects. The sample was made up of 107 obese and non-obese subjects, aged 50-74. All participants were given a multidimensional assessment, which included anthropometric, psycho-social and life-style evaluation. As per the protocol a structured life-style questionnaire designed to gather information on anthropometric measurements, socio-economic factors, physical activity, smoking, alcohol and food intake. The Symptom Checklist-90 (SCL-90) for the evaluation of a broad range of psychological problems and symptoms of psychopathology; the Binge Eating Scale (BES) for the assessment of disorders in the eating habits were administered. BMI was associated with age and education, socio-economic status and smoking in both genders. Psychological factors for obesity differed between overweight men and women. In conclusion, obesity and non-obesity appear as two different entities in some aspects. The increase in the prevalence of obesity in elderly subjects could lead to disability and age-related diseases. For this reason, greater insight of the factors related to the development of obesity is required to develop treatment strategies weight-loss prevention programs. [Copyright Elsevier B.V.] JF - Archives of Gerontology and Geriatrics AU - Marcellini, F AU - Giuli, C AU - Papa, R AU - Tirabassi, G AU - Faloia, E AU - Boscaro, M AU - Polito, A AU - Ciarapica, D AU - Zaccaria, M AU - Mocchegiani, E AD - Center of Psycho-social Aspects of Aging, Scientific-Technological Area, INRCA (Italian National Institute on Aging), Via S. Margherita 5, 1-60124 Ancona, Italy f.marcellini@inrca.it Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 195 EP - 206 PB - Elsevier Ltd, The Netherlands VL - 49 SN - 0167-4943, 0167-4943 KW - Obesity Binge eating disorder Elderly Body mass index KW - Elderly people KW - Symptoms KW - Obesity KW - Socioeconomic factors KW - Body Mass Index KW - Psychological aspects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57314511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Gerontology+and+Geriatrics&rft.atitle=OBESITY+AND+BODY+MASS+INDEX+%28BMI%29+IN+RELATION+TO+LIFE-STYLE+AND+PSYCHO-SOCIAL+ASPECTS&rft.au=Marcellini%2C+F%3BGiuli%2C+C%3BPapa%2C+R%3BTirabassi%2C+G%3BFaloia%2C+E%3BBoscaro%2C+M%3BPolito%2C+A%3BCiarapica%2C+D%3BZaccaria%2C+M%3BMocchegiani%2C+E&rft.aulast=Marcellini&rft.aufirst=F&rft.date=2009-01-01&rft.volume=49&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Archives+of+Gerontology+and+Geriatrics&rft.issn=01674943&rft_id=info:doi/10.1016%2Fj.archger.2009.09.029 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Obesity; Body Mass Index; Psychological aspects; Symptoms; Elderly people; Socioeconomic factors DO - http://dx.doi.org/10.1016/j.archger.2009.09.029 ER - TY - JOUR T1 - Autism Spectrum Disorders and Childhood-Onset Schizophrenia: Clinical and Biological Contributions to a Relation Revisited AN - 57284482; 200904711 AB - Objective: To highlight emerging evidence for clinical and biological links between autism/pervasive developmental disorder (PDD) and schizophrenia, with particular attention to childhood-onset schizophrenia (COS). Method: Clinical, demographic, and brain developmental data from the National Institute of Mental Health (and other) COS studies and selected family, imaging, and genetic data from studies of autism, PDD, and schizophrenia were reviewed. Results: In the two large studies that have examined this systematically, COS is preceded by and comorbid with PDD in 30% to 50% of cases. Epidemiological and family studies find association between the disorders. Both disorders have evidence of accelerated trajectories of anatomic brain development at ages near disorder onset. A growing number of risk genes and/or rare small chromosomal variants (microdeletions or duplications) are shared by schizophrenia and autism. Conclusions: Biological risk does not closely follow DSM phenotypes, and core neurobiological processes are likely common for subsets of these two heterogeneous clinical groups. Long-term prospective follow-up of autistic populations and greater diagnostic distinction between schizophrenia spectrum and autism spectrum disorders in adult relatives are needed. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Rapoport, Judith AU - Chavez, Alex AU - Greenstein, Deanna AU - Addington, Anjene AU - Gogtay, Nitin AD - Child Psychiatry Branch, NIMH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 10 EP - 18 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 1 SN - 0890-8567, 0890-8567 KW - schizophrenia, childhood, autism, genetics, brain development KW - Schizophrenia KW - Brain KW - Phenotypes KW - Autism KW - Comorbidity KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57284482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Autism+Spectrum+Disorders+and+Childhood-Onset+Schizophrenia%3A+Clinical+and+Biological+Contributions+to+a+Relation+Revisited&rft.au=Rapoport%2C+Judith%3BChavez%2C+Alex%3BGreenstein%2C+Deanna%3BAddington%2C+Anjene%3BGogtay%2C+Nitin&rft.aulast=Rapoport&rft.aufirst=Judith&rft.date=2009-01-01&rft.volume=48&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31818b1c63 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Autism; Autistic spectrum disorders; Brain; Phenotypes; Comorbidity DO - http://dx.doi.org/10.1097/CHI.0b013e31818b1c63 ER - TY - JOUR T1 - Are Patterns of Health Behavior Associated With Cancer Screening? AN - 57283881; 200906941 AB - Purpose. This study investigates the relationship between patterns of health behaviors and the use of cancer-screening tests while controlling for sociodemographic and health system factors. Design. Cross-sectional analysis of the 2000 National Health Interview (NHIS). Setting. Nationally representative sample. Subjects. Adults 50 years and older. Measures. Use of cancer-screening tests, health behaviors, sociodemographic factors, and health system factors from self-reported responses from the NHIS. Sixteen health behavior patterns were identified based on lifestyle recommendations for physical activity, tobacco use, alcohol consumption, and fruit and vegetable consumption. Results. Health behavior patterns, age, educational attainment, usual source of care, and health insurance were significantly associated with the use of breast, cervical, and colorectal cancer screening (p < .05). Approximate R2 for the four models ranged from .067 for colorectal cancer screening in women to .122 for cervical cancer screening. Having a usual source of care was the strongest correlate of screening; the magnitude of associations for health behavior patterns and demographic variables and screening was similar and much smaller than those for usual source of care. Conclusion. These findings demonstrate relationships between patterns of multiple health behaviors and use of recommended cancer-screening tests, even when accounting for factors known to influence test use. This suggests potential for addressing cancer screening in the context of multiple behavior change interventions once barriers to health care access are removed. Adapted from the source document. JF - American Journal of Health Promotion AU - Meissner, Helen I AU - Yabroff, K Robin AU - Dodd, Kevin W AU - Leader, Amy E AU - Ballard-Barbash, Rachel AU - Berrigan, David AD - Division of Cancer Control and Population Sciences. National Cancer Institute, Executive Plaza North, Suite 4102, 6130 Executive Blvd, MSC 7331, Bethesda, MD 20892-7331 Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 168 EP - 175 PB - AJHP Inc, West Bloomfield MI VL - 23 IS - 3 SN - 0890-1171, 0890-1171 KW - Health Behavior, Pattern, Cancer, Screening, Colon, Breast, Lifestyle, Prevention Research KW - Screening KW - Prevention KW - Health care KW - Colorectal cancer KW - Cancer KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57283881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Are+Patterns+of+Health+Behavior+Associated+With+Cancer+Screening%3F&rft.au=Meissner%2C+Helen+I%3BYabroff%2C+K+Robin%3BDodd%2C+Kevin+W%3BLeader%2C+Amy+E%3BBallard-Barbash%2C+Rachel%3BBerrigan%2C+David&rft.aulast=Meissner&rft.aufirst=Helen&rft.date=2009-01-01&rft.volume=23&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHPED N1 - SubjectsTermNotLitGenreText - Health behaviour; Screening; Prevention; Cancer; Colorectal cancer; Health care ER - TY - JOUR T1 - Repetitive TMS combined with exposure therapy for PTSD: A preliminary study AN - 57282110; 200907151 AB - Treatment for anxiety and post-traumatic stress disorder (PTSD) includes exposure therapy and medications, but some patients are refractory. Few studies of repetitive transcranial magnetic stimulation (rTMS) for anxiety or PTSD exist. In this preliminary report, rTMS was combined with exposure therapy for PTSD. Nine subjects with chronic, treatment-refractory PTSD were studied in a placebo-controlled, crossover design of imaginal exposure therapy with rTMS (1 Hz) versus sham. PTSD symptoms, serum and 24 h urine were obtained and analyzed. Effect sizes for PTSD symptoms were determined using Cohen's d. Active rTMS showed a larger effect size of improvement for hyperarousal symptoms compared to sham; 24-h urinary norepinephrine and serum T4 increased; serum prolactin decreased. Active rTMS with exposure may have symptomatic and physiological effects. Larger studies are needed to confirm these preliminary findings and verify whether rTMS plus exposure therapy has a role in the treatment of PTSD. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Osuch, Elizabeth A AU - Benson, Brenda E AU - Luckenbaugh, David A AU - Geraci, Marilla AU - Post, Robert M AU - McCann, Una AD - Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA, United States Elizabeth.osuch@lhsc.on.ca Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 54 EP - 59 PB - Elsevier Ltd, The Netherlands VL - 23 IS - 1 SN - 0887-6185, 0887-6185 KW - Post-traumatic stress disorder (PTSD) Transcranial magnetic stimulation (TMS) Psychological desensitization Psychological therapies Extinction KW - Transcranial magnetic stimulation KW - Posttraumatic stress disorder KW - Anxiety KW - Exposure therapy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Repetitive+TMS+combined+with+exposure+therapy+for+PTSD%3A+A+preliminary+study&rft.au=Osuch%2C+Elizabeth+A%3BBenson%2C+Brenda+E%3BLuckenbaugh%2C+David+A%3BGeraci%2C+Marilla%3BPost%2C+Robert+M%3BMcCann%2C+Una&rft.aulast=Osuch&rft.aufirst=Elizabeth&rft.date=2009-01-01&rft.volume=&rft.issue=190&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-79885-9_20 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Exposure therapy; Transcranial magnetic stimulation; Anxiety DO - http://dx.doi.org/10.1016/j.janxdis.2008.03.015 ER - TY - JOUR T1 - Sex Differences in WISC-III Profiles of Children with High-functioning Pervasive Developmental Disorders AN - 57281634; 200909488 AB - Using the Japanese version of the Wechsler Intelligence Scale for Children-Third Edition (WISC-III), 26 girls with high-functioning (IQ >= 70) pervasive developmental disorders (HFPDD) (mean age, 8.2 years) were compared with 116 boys with HFPDD (mean age, 9.0 years). Compared with the boys, the girls scored significantly higher on the Processing Speed index, Coding, and Symbol Search, but scored significantly lower on Block Design. Although both groups showed weakness on Comprehension in the verbal domain, the girls' subtest profile in the performance domain was relatively even and significantly different from the boys', which was characterized by a peak on Block Design. Such differences should be replicated, and possible behavioral, neurological, and genetic links to these sex differences should be clarified. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Koyama, Tomonori AU - Kamio, Yoko AU - Inada, Naoko AU - Kurita, Hiroshi AD - Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8553, Japan Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 135 EP - 141 PB - Springer, Dordrecht The Netherlands VL - 39 IS - 1 SN - 0162-3257, 0162-3257 KW - Intelligence KW - High functioning KW - Developmentally disabled children KW - Intelligence tests KW - Pervasive developmental disorders KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Sex+Differences+in+WISC-III+Profiles+of+Children+with+High-functioning+Pervasive+Developmental+Disorders&rft.au=Koyama%2C+Tomonori%3BKamio%2C+Yoko%3BInada%2C+Naoko%3BKurita%2C+Hiroshi&rft.aulast=Koyama&rft.aufirst=Tomonori&rft.date=2009-01-01&rft.volume=39&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0610-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Gender differences; Developmentally disabled children; Pervasive developmental disorders; High functioning; Intelligence tests; Intelligence DO - http://dx.doi.org/10.1007/s10803-008-0610-6 ER - TY - JOUR T1 - Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multicenter trial of buprenorphine-naloxone and clonidine in the NIDA clinical trials network drug and alcohol dependence AN - 57276955; 200907998 AB - Few studies in community settings have evaluated predictors, mediators, and moderators of treatment success for medically supervised opioid withdrawal treatment. This report presents new findings about these factors from a study of 344 opioid-dependent men and women prospectively randomized to either buprenorphine-naloxone or clonidine in an open-label 13-day medically supervised withdrawal study. Subjects were either inpatient or outpatient in community treatment settings; however not randomized by treatment setting. Medication type (buprenorphine-naloxone versus clonidine) was the single best predictor of treatment retention and treatment success, regardless of treatment setting. Compared to the outpatient setting, the inpatient setting was associated with higher abstinence rates but similar retention rates when adjusting for medication type. Early opioid withdrawal severity mediated the relationship between medication type and treatment outcome with buprenorphine-naloxone being superior to clonidine at relieving early withdrawal symptoms. Inpatient subjects on clonidine with lower withdrawal scores at baseline did better than those with higher withdrawal scores; inpatient subjects receiving buprenorphine-naloxone did better with higher withdrawal scores at baseline than those with lower withdrawal scores. No relationship was found between treatment outcome and age, gender, race, education, employment, marital status, legal problems, baseline depression, or length/severity of drug use. Tobacco use was associated with worse opioid treatment outcomes. Severe baseline anxiety symptoms doubled treatment success. Medication type (buprenorphine-naloxone) was the most important predictor of positive outcome; however the paper also considers other clinical and policy implications of other results, including that inpatient setting predicted better outcomes and moderated medication outcomes. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ziedonis, Douglas M AU - Amass, Leslie AU - Steinberg, Marc AU - Woody, George AU - Krejciiii, Jonathan AU - Annon, Jeffrey J AU - Cohen, Allan J AU - Waite-O'Brien, Nancy AU - Stine, Susan M AU - McCarty, Dennis AU - Reid, Malcolm S AU - Brown, Lawrence S, Jr AU - Maslansky, Robert AU - Winhusen, Theresa AU - Babcock, Dean AU - Brigham, Greg AU - Muir, Joan AU - Orr, Deborah AU - Buchan, Betty J AU - Horton, Terry AU - Ling, Walter AD - National Institute on Drug Abuse Clinical Trials Network (CTN), University of Massachusetts Medical School, New England Node, Worcester, MA 01581, USA Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 28 EP - 36 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 99 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Buprenorphine Outcome predictors Heroin dependence Detoxification Opiate withdrawal Clinical trial KW - Withdrawal KW - Clonidine KW - Opioids KW - Analgesics KW - Treatment methods KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Predictors+of+outcome+for+short-term+medically+supervised+opioid+withdrawal+during+a+randomized%2C+multicenter+trial+of+buprenorphine-naloxone+and+clonidine+in+the+NIDA+clinical+trials+network+drug+and+alcohol+dependence&rft.au=Ziedonis%2C+Douglas+M%3BAmass%2C+Leslie%3BSteinberg%2C+Marc%3BWoody%2C+George%3BKrejciiii%2C+Jonathan%3BAnnon%2C+Jeffrey+J%3BCohen%2C+Allan+J%3BWaite-O%27Brien%2C+Nancy%3BStine%2C+Susan+M%3BMcCarty%2C+Dennis%3BReid%2C+Malcolm+S%3BBrown%2C+Lawrence+S%2C+Jr%3BMaslansky%2C+Robert%3BWinhusen%2C+Theresa%3BBabcock%2C+Dean%3BBrigham%2C+Greg%3BMuir%2C+Joan%3BOrr%2C+Deborah%3BBuchan%2C+Betty+J%3BHorton%2C+Terry%3BLing%2C+Walter&rft.aulast=Ziedonis&rft.aufirst=Douglas&rft.date=2009-01-01&rft.volume=99&rft.issue=1-3&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.06.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Analgesics; Clonidine; Opioids; Withdrawal; Treatment methods DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.06.016 ER - TY - JOUR T1 - Prevalence of Enuresis and Its Association With Attention-Deficit/Hyperactivity Disorder Among U.S. Children: Results From a Nationally Representative Study AN - 57276756; 200904887 AB - Objective: There are no published nationally representative prevalence estimates of enuresis among children in the United States using standardized diagnostic criteria. This study sets out to describe the prevalence, demographic correlates, comorbidities, and service patterns for enuresis in a representative sample of U.S. children. Method: The diagnosis of enuresis was derived from parent-reported data for "enuresis, nocturnal" collected using the computerized version of the Diagnostic Interview Schedule for Children (C-DISC 4.0) from a nationally representative sample of 8- to 11-year-old children (n = 1, 136) who participated in the 2001-2004 National Health and Nutrition Examination Surveys. Results: The overall 12-month prevalence of enuresis was 4.45%. The prevalence in boys (6.21%) was significantly greater than that in girls (2.51 %). Enuresis was more common at younger ages and among black youth. Attention-deficit/ hyperactivity disorder (ADHD) was strongly associated with enuresis (odds ratio 2.88; 95% confidence interval 1.26-6.57). Only 36% of the enuretic children had received health services for enuresis. Conclusions: Enuresis is a common condition among children in the United States. Few families seek treatment for enuresis despite the potential for adverse effects on emotional health. Child health care professionals should routinely screen for enuresis and its effects on the emotional health of the child and the family. Assessment of ADHD should routinely include evaluation for enuresis and vice versa. Research on the explanations for the association between enuresis and ADHD is indicated. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Shreeram, Srirangam AU - He, Jian-Ping AU - Kalaydjian, Amanda AU - Brothers, Shannon AU - Merikangas, Kathleen Ries AD - Genetic Epidemiology, Branch, National Institute of Mental Health, 35 Convent Drive, 1A-202, MSC 3720, Bethesda, MD 20892-3720 s.shreeram@dc.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 35 EP - 41 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 1 SN - 0890-8567, 0890-8567 KW - enuresis, prevalence, health care use, comorbidities, ADHD KW - Enuresis KW - Attention deficit hyperactivity disorder KW - Children KW - Side effects KW - Hyperactivity KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Prevalence+of+Enuresis+and+Its+Association+With+Attention-Deficit%2FHyperactivity+Disorder+Among+U.S.+Children%3A+Results+From+a+Nationally+Representative+Study&rft.au=Shreeram%2C+Srirangam%3BHe%2C+Jian-Ping%3BKalaydjian%2C+Amanda%3BBrothers%2C+Shannon%3BMerikangas%2C+Kathleen+Ries&rft.aulast=Shreeram&rft.aufirst=Srirangam&rft.date=2009-01-01&rft.volume=48&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e318190045c LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Enuresis; Children; Prevalence; Attention deficit hyperactivity disorder; Hyperactivity; Side effects DO - http://dx.doi.org/10.1097/CHI.0b013e318190045c ER - TY - JOUR T1 - Testing in semiparametric models with interaction, with applications to gene-environment interactions AN - 37057000; 3822521 AB - Motivated from the problem of testing for genetic effects on complex traits in the presence of gene-environment interaction, we develop score tests in general semiparametric regression problems that involves Tukey style 1 degree-of-freedom form of interaction between parametrically and non-parametrically modelled covariates. We find that the score test in this type model, as recently developed by Chatterjee and co-workers in the fully parametric setting, is biased and requires undersmoothing to be valid in the presence of non-parametric components. Moreover, in the presence of repeated outcomes, the asymptotic distribution of the score test depends on the estimation of functions which are defined as solutions of integral equations, making implementation difficult and computationally taxing. We develop profiled score statistics which are unbiased and asymptotically efficient and can be performed by using standard bandwidth selection methods. In addition, to overcome the difficulty of solving functional equations, we give easy interpretations of the target functions, which in turn allow us to develop estimation procedures that can be easily implemented by using standard computational methods. We present simulation studies to evaluate type I error and power of the method proposed compared with a naive test that does not consider interaction. Finally, we illustrate our methodology by analysing data from a case-control study of colorectal adenoma that was designed to investigate the association between colorectal adenoma and the candidate gene NAT2 in relation to smoking history. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Maity, A AU - Carroll, R J AU - Mammen, E AU - Chatterjee, N AD - Texas A&M University ; Universität Mannheim ; National Cancer Institute Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 75 EP - 96 VL - 71 IS - 1 SN - 1369-7412, 1369-7412 KW - Sociology KW - Semiparametric models KW - Evaluation KW - Measurement KW - Genes KW - Quantitative analysis KW - Regression analysis KW - Linear models KW - Estimation KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37057000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Testing+in+semiparametric+models+with+interaction%2C+with+applications+to+gene-environment+interactions&rft.au=Maity%2C+A%3BCarroll%2C+R+J%3BMammen%2C+E%3BChatterjee%2C+N&rft.aulast=Maity&rft.aufirst=A&rft.date=2009-01-01&rft.volume=71&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5455 1678; 4403 7854; 10739 12228 10919; 7419 8163; 7854; 10530 3279 971 3286; 4551; 12228 10919 ER - TY - JOUR T1 - BacA, an ABC Transporter Involved in Maintenance of Chronic Murine Infections with Mycobacterium tuberculosis AN - 21504597; 12493391 AB - BacA is an inner membrane protein associated with maintenance of chronic infections in several diverse host-pathogen interactions. To understand the function of the bacA gene in Mycobacterium tuberculosis (Rv1819c), we insertionally inactivated this gene and analyzed the resulting mutant for a variety of phenotypes. BacA deficiency in M. tuberculosis did not affect sensitivity to detergents, acidic pH, and zinc, indicating that there was no global compromise in membrane integrity, and a comprehensive evaluation of the major lipid constituents of the cell envelope failed to reveal any significant differences. Infection of mice with this mutant revealed no impact on establishment of infection but a profound effect on maintenance of extended chronic infection and ultimate outcome. As in alphaproteobacteria, deletion of BacA in M. tuberculosis led to increased bleomycin resistance, and heterologous expression of the M. tuberculosis BacA homolog in Escherichia coli conferred sensitivity to antimicrobial peptides. These results suggest a striking conservation of function for BacA-related proteins in transport of a critical molecule that determines the outcome of the host-pathogen interaction. JF - Journal of Bacteriology AU - Domenech, Pilar AU - Kobayashi, Hajime AU - LeVier, Kristin AU - Walker, Graham C AU - Barry III, Clifton E AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, 33 North Drive, Bethesda, Maryland 20892, cbarry@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 477 EP - 485 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 2 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Protein transport KW - ABC transporter KW - Detergents KW - Cell envelopes KW - Lipids KW - Membrane proteins KW - Bleomycin KW - Inner membranes KW - Host-pathogen interactions KW - Zinc KW - Chronic infection KW - Escherichia coli KW - Conservation KW - Tuberculosis KW - pH effects KW - Antimicrobial peptides KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21504597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=BacA%2C+an+ABC+Transporter+Involved+in+Maintenance+of+Chronic+Murine+Infections+with+Mycobacterium+tuberculosis&rft.au=Domenech%2C+Pilar%3BKobayashi%2C+Hajime%3BLeVier%2C+Kristin%3BWalker%2C+Graham+C%3BBarry+III%2C+Clifton+E&rft.aulast=Domenech&rft.aufirst=Pilar&rft.date=2009-01-01&rft.volume=191&rft.issue=2&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01132-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Protein transport; Detergents; ABC transporter; Lipids; Cell envelopes; Membrane proteins; Bleomycin; Host-pathogen interactions; Inner membranes; Chronic infection; Zinc; Conservation; Tuberculosis; Antimicrobial peptides; pH effects; Escherichia coli; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/JB.01132-08 ER - TY - JOUR T1 - The Crp-Activated Small Noncoding Regulatory RNA CyaR (RyeE) Links Nutritional Status to Group Behavior , AN - 21501153; 12493392 AB - Small noncoding regulatory RNAs (sRNAs) play a key role in regulating the expression of many genes in Escherichia coli and other bacteria. Many of the sRNAs identified in E. coli bind to mRNAs in an Hfq-dependent manner and stimulate or inhibit translation of the mRNAs. Several sRNAs are regulated by well-studied global regulators. Here, we report characterization of the CyaR (RyeE) sRNA, which was previously identified in a global search for sRNAs in E. coli. We demonstrated that CyaR is positively regulated by the global regulator Crp under conditions in which cyclic AMP levels are high. We showed by using microarray analysis and Northern blotting that several genes are negatively regulated by CyaR, including ompX, encoding a major outer membrane protein; luxS, encoding the autoinducer-2 synthase; nadE, encoding an essential NAD synthetase; and yqaE, encoding a predicted membrane protein with an unknown function. Using translational lacZ fusions to yqaE, ompX, nadE, and luxS, we demonstrated that the negative regulation of these genes by CyaR occurs at the posttranscriptional level and is direct. Different portions of a highly conserved 3' region of CyaR are predicted to pair with sequences near the ribosome binding site of each of these targets; mutations in this sequence affected regulation, and compensatory mutations in the target mRNA restored regulation, confirming that there is direct regulation by the sRNA. These results provide insight into the mechanisms by which Crp negatively regulates genes such as luxS and ompX and provide a link between catabolite repression, quorum sensing, and nitrogen assimilation in E. coli. JF - Journal of Bacteriology AU - Lay, Nicholas De AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, susang@helix.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 461 EP - 476 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 2 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Nutritional status KW - Translation KW - LuxS protein KW - quorum sensing KW - Cyclic AMP KW - Transcription KW - Ribosomes KW - Membrane proteins KW - Northern blotting KW - NAD KW - Gene regulation KW - Escherichia coli KW - Catabolite repression KW - Conserved sequence KW - Post-transcription KW - Major outer membrane protein KW - Mutation KW - N-octanoylhomoserine lactone KW - Nitrogen KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21501153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Crp-Activated+Small+Noncoding+Regulatory+RNA+CyaR+%28RyeE%29+Links+Nutritional+Status+to+Group+Behavior+%2C&rft.au=Lay%2C+Nicholas+De%3BGottesman%2C+Susan&rft.aulast=Lay&rft.aufirst=Nicholas&rft.date=2009-01-01&rft.volume=191&rft.issue=2&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01157-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Nutritional status; Translation; LuxS protein; quorum sensing; Cyclic AMP; Transcription; Ribosomes; Membrane proteins; Northern blotting; NAD; Gene regulation; Catabolite repression; Conserved sequence; Major outer membrane protein; Post-transcription; Mutation; N-octanoylhomoserine lactone; Nitrogen; Escherichia coli DO - http://dx.doi.org/10.1128/JB.01157-08 ER - TY - JOUR T1 - Trends in Prokaryotic Evolution Revealed by Comparison of Closely Related Bacterial and Archaeal Genomes AN - 21498589; 12493367 AB - In order to explore microevolutionary trends in bacteria and archaea, we constructed a data set of 41 alignable tight genome clusters (ATGCs). We show that the ratio of the medians of nonsynonymous to synonymous substitution rates (dN/dS) that is used as a measure of the purifying selection pressure on protein sequences is a stable characteristic of the ATGCs. In agreement with previous findings, parasitic bacteria, notwithstanding the sometimes dramatic genome shrinkage caused by gene loss, are typically subjected to relatively weak purifying selection, presumably owing to relatively small effective population sizes and frequent bottlenecks. However, no evidence of genome streamlining caused by strong selective pressure was found in any of the ATGCs. On the contrary, a significant positive correlation between the genome size, as well as gene size, and selective pressure was observed, although a variety of free-living prokaryotes with very close selective pressures span nearly the entire range of genome sizes. In addition, we examined the connections between the sequence evolution rate and other genomic features. Although gene order changes much faster than protein sequences during the evolution of prokaryotes, a strong positive correlation was observed between the QUOTATION_MARKrearrangement distanceQUOTATION_MARK and the amino acid distance, suggesting that at least some of the events leading to genome rearrangement are subjected to the same type of selective constraints as the evolution of amino acid sequences. JF - Journal of Bacteriology AU - Novichkov, Pavel S AU - Wolf, Yuri I AU - Dubchak, Inna AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, koonin@ncbi.nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 65 EP - 73 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 1 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Bacteria KW - Gene order KW - Data processing KW - Archaea KW - gene rearrangement KW - Atrophy KW - Prokaryotes KW - genomics KW - Evolution KW - A 01310:Products of Microorganisms KW - G 07770:Bacteria KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Trends+in+Prokaryotic+Evolution+Revealed+by+Comparison+of+Closely+Related+Bacterial+and+Archaeal+Genomes&rft.au=Novichkov%2C+Pavel+S%3BWolf%2C+Yuri+I%3BDubchak%2C+Inna%3BKoonin%2C+Eugene+V&rft.aulast=Novichkov&rft.aufirst=Pavel&rft.date=2009-01-01&rft.volume=191&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01237-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Gene order; gene rearrangement; Atrophy; genomics; Prokaryotes; Evolution; Bacteria; Archaea DO - http://dx.doi.org/10.1128/JB.01237-08 ER - TY - JOUR T1 - The Human Papillomavirus Type 8 E2 Tethering Protein Targets the Ribosomal DNA Loci of Host Mitotic Chromosomes AN - 21490227; 12493861 AB - For many papillomaviruses, the viral protein E2 tethers the viral genome to the host mitotic chromosomes to ensure persistent, long-term maintenance of the genome during cell division. Our previous studies of E2 proteins from different genera of papillomaviruses have shown that they bind to different regions of the host chromosomes during mitosis. For example, bovine papillomavirus type 1 (BPV-1) E2 binds to all chromosomes as small speckles in complex with the cellular protein Brd4. In contrast, the human papillomavirus type 8 (HPV-8) E2 protein binds as large speckles at the pericentromeric regions of chromosomes. Here we show that these speckles do not contain Brd4, and unlike that of BPV-1, the N-terminal Brd4-interacting domain of HPV-8 E2 is not required for chromosome binding. In contrast to BPV-1 E2, the HPV-8 E2 protein targets the short arms of acrocentric mitotic chromosomes. Furthermore, the E2 protein interacts with the repeated ribosomal DNA genes found in this location and colocalizes with UBF, the RNA polymerase I transcription factor. Therefore, HPV-8 E2 genome tethering occurs by a Brd4-independent mechanism through a novel interaction with specific regions of mitotic chromosomes. Thus, a wide range of viruses have adopted the strategy of linking their genomes to host chromosomes, but individual viruses use different chromosomal targets. Characterization of these targets will enable the development of antiviral therapies to eliminate the viral genomes from infected cells. JF - Journal of Virology AU - Poddar, Atasi AU - Reed, Shawna C AU - McPhillips, Maria G AU - Spindler, Jonathan E AU - McBride, Alison A AD - Laboratory of Viral Diseases, NIAID, NIH, Bethesda, Maryland, amcbride@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 640 EP - 650 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 2 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - Chromosomes KW - Cell division KW - DNA-directed RNA polymerase KW - Transcription factors KW - Mitosis KW - Bovine papillomavirus KW - DNA KW - E2 protein KW - Repeated DNA sequences KW - Human papillomavirus KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21490227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+Human+Papillomavirus+Type+8+E2+Tethering+Protein+Targets+the+Ribosomal+DNA+Loci+of+Host+Mitotic+Chromosomes&rft.au=Poddar%2C+Atasi%3BReed%2C+Shawna+C%3BMcPhillips%2C+Maria+G%3BSpindler%2C+Jonathan+E%3BMcBride%2C+Alison+A&rft.aulast=Poddar&rft.aufirst=Atasi&rft.date=2009-01-01&rft.volume=83&rft.issue=2&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01936-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Genomes; DNA-directed RNA polymerase; Cell division; Chromosomes; Mitosis; Transcription factors; DNA; E2 protein; Repeated DNA sequences; Bovine papillomavirus; Human papillomavirus DO - http://dx.doi.org/10.1128/JVI.01936-08 ER - TY - JOUR T1 - Differential Sensitivity of QUOTATION_MARKOldQUOTATION_MARK versus QUOTATION_MARKNewQUOTATION_MARK APOBEC3G to Human Immunodeficiency Virus Type 1 Vif AN - 21480010; 12493845 AB - HIV-1 Vif counteracts the antiviral activity of APOBEC3G by inhibiting its encapsidation into virions. Here, we compared the relative sensitivity to Vif of APOBEC3G in stable HeLa cells containing APOBEC3G (HeLa-A3G cells) versus that of newly synthesized APOBEC3G. We observed that newly synthesized APOBEC3G was more sensitive to degradation than preexisting APOBEC3G. Nevertheless, preexisting and transiently expressed APOBEC3G were packaged with similar efficiencies into vif-deficient human immunodeficiency virus type 1 (HIV-1) virions, and Vif inhibited the encapsidation of both forms of APOBEC3G into HIV particles equally well. Our results suggest that HIV-1 Vif preferentially induces degradation of newly synthesized APOBEC3G but indiscriminately inhibits encapsidation of QUOTATION_MARKoldQUOTATION_MARK and QUOTATION_MARKnewQUOTATION_MARK APOBEC3G. JF - Journal of Virology AU - Goila-Gaur, Ritu AU - Khan, Mohammad A AU - Miyagi, Eri AU - Strebel, Klaus AD - Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, Maryland 20892-0460, kstrebel@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 1156 EP - 1160 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 2 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Human immunodeficiency virus 1 KW - Encapsidation KW - Antiviral activity KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21480010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Cluster+of+Cases+of+Nosocomial+Legionnaires+Disease+Linked+to+a+Contaminated+Hospital+Decorative+Water+Fountain&rft.au=Palmore%2C+Tara+N%3BStock%2C+Frida%3BWhite%2C+Margaret%3BBordner%2C+MaryAnn%3BMichelin%2C+Angela%3BBennett%2C+John+E%3BMurray%2C+Patrick+R%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=8&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F598855 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Virions; Encapsidation; Antiviral activity; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.01734-08 ER - TY - JOUR T1 - Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods AN - 21445903; 11866173 AB - Although several genes (including a strong effect in the human leukocyte antigen (HLA) region) and some environmental factors have been implicated to cause susceptibility to rheumatoid arthritis (RA), the etiology of the disease is not completely understood. The ability to screen the entire genome for association to complex diseases has great potential for identifying gene effects. However, the efficiency of gene detection in this situation may be improved by methods specifically designed for high-dimensional data. The aim of this study was to compare how three different statistical approaches, multifactor dimensionality reduction (MDR), random forests (RF), and an omnibus approach, worked in identifying gene effects (including gene-gene interaction) associated with RA. We developed a test set of genes based on previous linkage and association findings and tested all three methods. In the presence of the HLA shared-epitope factor, other genes showed weaker effects. All three methods detected SNPs in PTPN22 and TRAF1-C5 as being important. But we did not detect any new genes in this study. We conclude that the three high-dimensional methods are useful as an initial screening for gene associations to identify promising genes for further modeling and additional replication studies. JF - BMC Proceedings AU - Liang, Xueying AU - Gao, Ying AU - Lam, Tram K AU - Li, Qizhai AU - Falk, Cathy AU - Yang, Xiaohong R AU - Goldstein, Alisa M AU - Goldin, Lynn R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA, liangx2@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S79 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 3 IS - Suppl 7 KW - Calcium & Calcified Tissue Abstracts; Immunology Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Histocompatibility antigen HLA KW - Genomes KW - Rheumatoid arthritis KW - Etiology KW - Statistics KW - Data processing KW - Replication KW - Single-nucleotide polymorphism KW - Forests KW - Environmental factors KW - Protein-tyrosine-phosphatase KW - G 07720:Immunogenetics KW - T 2055:Laboratory Methods KW - F 06930:Autoimmunity KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21445903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Successful+Mandatory+Influenza+Vaccination+Campaign+Using+an+Innovative+Electronic+Tracking+System&rft.au=Palmore%2C+Tara+N%3BVandersluis%2C+JPatrick%3BMorris%2C+Joan%3BMichelin%2C+Angela%3BRuprecht%3B%2C+Lisa+M%3BSchmitt%2C+James+M%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=12&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F648084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Genomes; Histocompatibility antigen HLA; Etiology; Rheumatoid arthritis; Data processing; Statistics; Single-nucleotide polymorphism; Replication; Forests; Environmental factors; Protein-tyrosine-phosphatase ER - TY - JOUR T1 - The potential for automated question answering in the context of genomic medicine: an assessment of existing resources and properties of answers AN - 21442870; 11861941 AB - Knowledge gained in studies of genetic disorders is reported in a growing body of biomedical literature containing reports of genetic variation in individuals that map to medical conditions and/or response to therapy. These scientific discoveries need to be translated into practical applications to optimize patient care. Translating research into practice can be facilitated by supplying clinicians with research evidence. We assessed the role of existing tools in extracting answers to translational research questions in the area of genomic medicine. We: evaluate the coverage of translational research terms in the Unified Medical Language Systems (UMLS) Metathesaurus; determine where answers are most often found in full-text articles; and determine common answer patterns. Findings suggest that we will be able to leverage the UMLS in development of natural language processing algorithms for automated extraction of answers to translational research questions from biomedical text in the area of genomic medicine. JF - BMC Bioinformatics AU - Overby, Casey Lynnette AU - Tarczy-Hornoch, Peter AU - Demner-Fushman, Dina AD - Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, BHHS, Bethesda, MD, USA, ddemner@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S8 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 IS - Suppl 9 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Algorithms KW - Genetic diversity KW - Language KW - Bioinformatics KW - genomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21442870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Intensive+care+unit-acquired+neuromyopathy+and+corticosteroids+in+survivors+of+persistent+ARDS&rft.au=Hough%2C+Catherine+L%3BSteinberg%2C+Kenneth+P%3BTaylor+Thompson%2C+B%3BRubenfeld%2C+Gordon+D%3BHudson%2C+Leonard+D&rft.aulast=Hough&rft.aufirst=Catherine&rft.date=2009-01-01&rft.volume=35&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-008-1304-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Translation; genomics; Language; Algorithms; Genetic diversity; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-10-S9-S8 ER - TY - JOUR T1 - A Successful Mandatory Influenza Vaccination Campaign Using an Innovative Electronic Tracking System AN - 21333289; 11839565 AB - Background. Although influenza vaccination of healthcare workers reduces influenza-like illness and overall mortality among patients, national rates of vaccination for healthcare providers are unacceptably low. We report the implementation of a new mandatory vaccination policy by means of a streamlined electronic enrollment and vaccination tracking system at the National Institutes of Health (NIH) Clinical Center. Objective. To evaluate the outcome of a new mandatory staff influenza vaccination program. Methods. A new hospital policy endorsed by all the component NIH institutes and the Clinical Center departments mandated that employees who have patient contact either be vaccinated annually against influenza or sign a declination specifying the reason(s) for refusal. Those who fail to comply would be required to appear before the Medical Executive Committee to explain their rationale. We collected in a database the names of all physician and nonphysician staff who had patient contact. When a staff member either was vaccinated or declined vaccination, a simple system of badge scanning and bar-coded data entry captured essential data. The database was continuously updated, and it provided a list of noncompliant employees with whom to follow up. Results. By February 12, 2009, all 2,754 identified patient-care employees either were vaccinated or formally declined vaccination. Among those, 2,424 (88%) were vaccinated either at the NIH or elsewhere, 36 (1.3%) reported medical contraindications, and 294 (10.7%) declined vaccination for other reasons. Among the 294 employees without medical contraindications who declined, the most frequent reason given for declination was concern about side effects. Conclusions. Implementation of a novel vaccination tracking process and a hospital policy requiring influenza vaccination or declination yielded dramatic improvement in healthcare worker vaccination rates and likely will result in increased patient safety in our hospital. JF - Infection Control and Hospital Epidemiology AU - Palmore, Tara N AU - Vandersluis, JPatrick AU - Morris, Joan AU - Michelin, Angela AU - Ruprecht AU - , Lisa M AU - Schmitt, James M AU - Henderson, David K AD - Clinical Center and the Occupational Medical Service, Division of Occupational Health and Safety, National Institutes of Health, Bethesda, Maryland, dkh@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1137 EP - 1142 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 12 SN - 0899-823X, 0899-823X KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21333289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Successful+Mandatory+Influenza+Vaccination+Campaign+Using+an+Innovative+Electronic+Tracking+System&rft.au=Palmore%2C+Tara+N%3BVandersluis%2C+JPatrick%3BMorris%2C+Joan%3BMichelin%2C+Angela%3BRuprecht%3B%2C+Lisa+M%3BSchmitt%2C+James+M%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=12&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F648084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1086/648084 ER - TY - JOUR T1 - Malaria Control, Elimination, and Eradication: The Role of the Evolving Biomedical Research Agenda AN - 21330767; 11839604 JF - Journal of Infectious Diseases AU - Hall, BFenton AU - Fauci, Anthony S AD - Parasitology and International Programs Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, lhall@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1639 EP - 1643 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 11 SN - 0022-1899, 0022-1899 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources KW - Human diseases KW - Infectious diseases KW - Malaria KW - Public health KW - K 03400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21330767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Malaria+Control%2C+Elimination%2C+and+Eradication%3A+The+Role+of+the+Evolving+Biomedical+Research+Agenda&rft.au=Hall%2C+BFenton%3BFauci%2C+Anthony+S&rft.aulast=Hall&rft.aufirst=BFenton&rft.date=2009-01-01&rft.volume=200&rft.issue=11&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F646611 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Human diseases; Infectious diseases; Malaria; Public health DO - http://dx.doi.org/10.1086/646611 ER - TY - JOUR T1 - Total Pesticide Exposure Calculation among Vegetable Farmers in Benguet, Philippines AN - 21282119; 11829330 AB - This was a cross-sectional study that investigated pesticide exposure and its risk factors targeting vegetable farmers selected through cluster sampling. The sampling size calculated with [[PQ_REPLACE:[math]]]P=.05 was 211 vegetable farmers and 37 farms. The mean usage of pesticide was 21.35 liters. Risk factors included damaged backpack sprayer (34.7%), spills on hands (31.8%), and spraying against the wind (58%). The top 3 pesticides used were pyrethroid (46.4%), organophosphates (24.2%), and carbamates (21.3%). Those who were exposed to fungicides and insecticides also had higher total pesticide exposure. Furthermore, a farmer who was a pesticide applicator, mixer, loader, and who had not been given instructions through training was at risk of having higher pesticide exposure. The most prevalent symptoms were headache (64.1%), muscle pain (61.1%), cough (45.5%), weakness (42.4%), eye pain (39.9%), chest pain (37.4%), and eye redness (33.8%). The data can be used for the formulation of an integrated program on safety and health in the vegetable industry. JF - Journal of Environmental and Public Health AU - Lu, Jinky Leilanie AD - National Institutes of Health University of the Philippines Manila Ermita, Manila 1100, jinky_lu@yahoo.com Y1 - 2009 PY - 2009 DA - 2009 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2009 KW - Environmental Engineering Abstracts; Environment Abstracts KW - Philippines KW - Eye KW - Training KW - Organophosphates KW - Sprays KW - Muscles KW - pain KW - farms KW - Fungicides KW - Pesticides KW - EE 10:General Environmental Engineering KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21282119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+and+Public+Health&rft.atitle=Total+Pesticide+Exposure+Calculation+among+Vegetable+Farmers+in+Benguet%2C+Philippines&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2009-01-01&rft.volume=2009&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+and+Public+Health&rft.issn=1687-9813&rft_id=info:doi/10.1155%2F2009%2F412054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Philippines; Pesticides; pain; Eye; Sprays; Organophosphates; Muscles; Fungicides; farms; Training DO - http://dx.doi.org/10.1155/2009/412054 ER - TY - JOUR T1 - Chlamydia trachomatis Polymorphic Membrane Protein D Is an Oligomeric Autotransporter with a Higher-Order Structure AN - 21280180; 12511026 AB - Chlamydia trachomatis is a globally important obligate intracellular bacterial pathogen that is a leading cause of sexually transmitted disease and blinding trachoma. Effective control of these diseases will likely require a preventative vaccine. C. trachomatis polymorphic membrane protein D (PmpD) is an attractive vaccine candidate as it is conserved among C. trachomatis strains and is a target of broadly cross-reactive neutralizing antibodies. We show here that immunoaffinity-purified native PmpD exists as an oligomer with a distinct 23-nm flower-like structure. Two-dimensional blue native-sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses showed that the oligomers were composed of full-length PmpD (p155) and two proteolytically processed fragments, the p73 passenger domain (PD) and the p82 translocator domain. We also show that PmpD undergoes an infection-dependent proteolytic processing step late in the growth cycle that yields a soluble extended PD (p111) that was processed into a p73 PD and a novel p30 fragment. Interestingly, soluble PmpD peptides possess putative eukaryote-interacting functional motifs, implying potential secondary functions within or distal to infected cells. Collectively, our findings show that PmpD exists as two distinct forms, a surface-associated oligomer exhibiting a higher-order flower-like structure and a soluble form restricted to infected cells. We hypothesize that PmpD is a multifunctional virulence factor important in chlamydial pathogenesis and could represent novel vaccine or drug targets for the control of human chlamydial infections. JF - Infection and Immunity AU - Swanson, Kena A AU - Taylor, Lacey D AU - Frank, Shaun D AU - Sturdevant, Gail L AU - Fischer, Elizabeth R AU - Carlson, John H AU - Whitmire, William M AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, hcaldwell@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 508 EP - 516 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Proteolysis KW - virulence factors KW - Sexually-transmitted diseases KW - Disease control KW - Chlamydia trachomatis KW - Membrane proteins KW - Pathogens KW - Immunity KW - Infection KW - Gel electrophoresis KW - Trachoma KW - Disease transmission KW - Virulence KW - Antibodies KW - Growth KW - Proteins KW - Vaccines KW - Drugs KW - A 01490:Miscellaneous KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21280180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Chlamydia+trachomatis+Polymorphic+Membrane+Protein+D+Is+an+Oligomeric+Autotransporter+with+a+Higher-Order+Structure&rft.au=Swanson%2C+Kena+A%3BTaylor%2C+Lacey+D%3BFrank%2C+Shaun+D%3BSturdevant%2C+Gail+L%3BFischer%2C+Elizabeth+R%3BCarlson%2C+John+H%3BWhitmire%2C+William+M%3BCaldwell%2C+Harlan+D&rft.aulast=Swanson&rft.aufirst=Kena&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01173-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Virulence; Growth; Antibodies; Disease control; Proteins; Immunity; Pathogens; Vaccines; Disease transmission; Proteolysis; Sexually-transmitted diseases; virulence factors; Membrane proteins; Infection; Drugs; Gel electrophoresis; Trachoma; Chlamydia trachomatis DO - http://dx.doi.org/10.1128/IAI.01173-08 ER - TY - JOUR T1 - Perspective on Malaria Eradication: Is Eradication Possible without Modifying the Mosquito? AN - 21274813; 11839605 JF - Journal of Infectious Diseases AU - Miller, Louis H AU - Pierce, Susan K AD - The Malaria Vaccine Development Branch and Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, lomiller@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1644 EP - 1645 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 11 SN - 0022-1899, 0022-1899 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; Entomology Abstracts KW - Human diseases KW - Infectious diseases KW - Culicidae KW - Malaria KW - Aquatic insects KW - Public health KW - K 03400:Human Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21274813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Perspective+on+Malaria+Eradication%3A+Is+Eradication+Possible+without+Modifying+the+Mosquito%3F&rft.au=Miller%2C+Louis+H%3BPierce%2C+Susan+K&rft.aulast=Miller&rft.aufirst=Louis&rft.date=2009-01-01&rft.volume=200&rft.issue=11&rft.spage=1644&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F646612 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Human diseases; Infectious diseases; Malaria; Aquatic insects; Public health; Culicidae DO - http://dx.doi.org/10.1086/646612 ER - TY - JOUR T1 - The Effect of Exercise Intensity on Serum Leptin and C-Reactive Protein Levels AN - 21233223; 11774511 AB - Recently, serum leptin and C-reactive protein (CRP) levels have been regarded as independent predictive factors for heart disease. Although exercise intensity and duration may influence leptin and CRP concentrations, few studies have investigated this. In addition, leptin and CRP exhibit trends (downward and upward, respectively) after an acute bout of aerobic exercise. There seems to be a negative association between them, which may differ from the baseline; however, no study has tested this assumption. Therefore, we investigated the effect of exercise intensity on serum leptin and CRP levels and compared changes and differences in both relationships with different exercise intensities. In addition to the VO sub(2max) test, 13 male subjects (21.5 c 1.8 years old, 18.5 c 4.0%body fat, 55.0 c 3.8 mL ; kg super(-1) ; min super(-1) VO sub(2max)) exercised at two other exercise intensities (85% VO sub(2max) and 65% VO sub(2max)) in a randomized order. Blood samples were collected before and immediately after each trial to analyze pre- and post-exercise leptin and CRP concentrations in the three trials. While there were no significant differences in post-exercise leptin and CRP levels among the different exercise intensities, there were significant differences between leptin and CRP concentrations before and after exercise bouts corresponding to 65% and 85% VO sub(2max). In addition, post-exercise leptin and CRP levels were not associated. The results of this study suggest that leptin and CRP do not differ among different exercise intensities. Alteration in CRP and body fat percentage did not contribute to the change in leptin in these acute exercise models. JF - Journal of Exercise Science and Fitness AU - Tsao, T-H AU - Hsu, C-H AU - Yang, C-B AU - Liou, T-L AD - Department of Recreation Sports and Health Promotion, National Pingtung University of Science and Technology, 1 Hseuh-Fu Road, Nei-Pu Township, Pingtung 912, TAIWAN, thtsao@mail.npust.edu.tw Y1 - 2009 PY - 2009 DA - 2009 SP - 98 EP - 103 VL - 7 IS - 2 SN - 1728-869X, 1728-869X KW - Physical Education Index KW - Fitness KW - Blood KW - Aerobics KW - Exercise (intensity) KW - Analysis KW - Proteins KW - Hormones KW - Maximum oxygen consumption KW - Heart diseases KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21233223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exercise+Science+and+Fitness&rft.atitle=The+Effect+of+Exercise+Intensity+on+Serum+Leptin+and+C-Reactive+Protein+Levels&rft.au=Tsao%2C+T-H%3BHsu%2C+C-H%3BYang%2C+C-B%3BLiou%2C+T-L&rft.aulast=Tsao&rft.aufirst=T-H&rft.date=2009-01-01&rft.volume=7&rft.issue=2&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exercise+Science+and+Fitness&rft.issn=1728869X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Fitness; Blood; Aerobics; Exercise (intensity); Analysis; Proteins; Maximum oxygen consumption; Hormones; Heart diseases ER - TY - JOUR T1 - Human Type 1 and 17 Responses in Latent Tuberculosis Are Modulated by Coincident Filarial Infection through Cytotoxic T Lymphocyte Antigen-4 and Programmed Death-1 AN - 21222190; 11189284 AB - Mycobacterium tuberculosis and filarial coinfection is highly prevalent, and the presence of a tissue-invasive helminth may modulate the predominant type 1 T helper (Th1; interferon [IFN]--mediated) response needed to control M. tuberculosis infection. By analyzing the cellular responses to mycobacterial antigens in patients who had latent tuberculosis with or without filarial infection, we were able to demonstrate that filarial infection coincident with M. tuberculosis infection significantly diminishes M. tuberculosis-specific Th1 (interleukin [IL]-12 and IFN-) and type 17 T helper (Th17; IL-23 and IL-17) responses related to increased expression of cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1. Blockade of CTLA-4 restored production of both IFN- and IL-17, whereas PD-1 blockade restored IFN- production only. Thus, coincident filarial infection exerted a profound inhibitory effect on protective mycobacteria-specific Th1 and Th17 responses in latent tuberculosis, suggesting a mechanism by which concomitant filarial (and other systemic helminth) infections predispose to the development of active tuberculosis in humans. JF - Journal of Infectious Diseases AU - Babu, Subash AU - Bhat, Sajid Q AU - Kumar, NPavan AU - Jayantasri, S AU - Rukmani, S AU - Kumaran, Paul AU - Gopi, P G AU - Kolappan, C AU - Kumaraswami, V AU - Nutman, Thomas B AD - National Institutes of Health-International Center for Excellence in Research and Tuberculosis Research Center, Chennai, India, sbabu@mail.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 288 EP - 298 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 2 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Interferon KW - PD-1 protein KW - Cytotoxicity KW - Interleukin 23 KW - CTLA-4 protein KW - Helper cells KW - Interleukin 17 KW - Lymphocytes T KW - Tuberculosis KW - Infection KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21222190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Human+Type+1+and+17+Responses+in+Latent+Tuberculosis+Are+Modulated+by+Coincident+Filarial+Infection+through+Cytotoxic+T+Lymphocyte+Antigen-4+and+Programmed+Death-1&rft.au=Babu%2C+Subash%3BBhat%2C+Sajid+Q%3BKumar%2C+NPavan%3BJayantasri%2C+S%3BRukmani%2C+S%3BKumaran%2C+Paul%3BGopi%2C+P+G%3BKolappan%2C+C%3BKumaraswami%2C+V%3BNutman%2C+Thomas+B&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2009-01-01&rft.volume=200&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - PD-1 protein; Interferon; Cytotoxicity; Interleukin 23; CTLA-4 protein; Interleukin 17; Helper cells; Lymphocytes T; Tuberculosis; Infection; Mycobacterium tuberculosis ER - TY - JOUR T1 - HIV-1 RNA Dimerization: It Takes Two to Tango AN - 21213297; 11149485 AB - Each viral particle of HIV-1, the infectious agent of AIDS, contains two copies of the full-length viral genomic RNA. Encapsldating two copies of genomic RNA is one of the characteristics of the retrovirus family. The two RNA molecules are both positive-sense and often identical; furthermore, each RNA encodes the full complement of genetic information required for viral replication. The two strands of RNA are intricately entwined within the core of the mature infectious virus as a ribonuclear complex with the viral proteins, including nucleocapsid. Multiple steps in the biogenesis of the genomic full-length RNA are involved in achieving this location and dimeric state. The viral sequences and proteins involved in the process of RNA dimerization, both for the initial interstrand contact and subsequent steps that result in the condensed, stable conformation of the genomic RNA, are outlined in this review. In addition, the impact of the dimeric state of HIV-1 viral RNA is discussed with respect to its importance in efficient viral replication and, consequently, the potential development of antiviral strategies designed to disrupt the formation of dimeric RNA. JF - AIDS Reviews AU - Moore, MD AU - Hu, W-S AD - HIV Drug Resistance Program, National Cancer Institute, Frederick, MD, USA, whu@ncifcrf.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 91 EP - 102 VL - 11 IS - 2 SN - 1139-6121, 1139-6121 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Retrovirus KW - RNA KW - Replication KW - Human immunodeficiency virus 1 KW - Nucleocapsids KW - genomics KW - Conformation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21213297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Reviews&rft.atitle=HIV-1+RNA+Dimerization%3A+It+Takes+Two+to+Tango&rft.au=Moore%2C+MD%3BHu%2C+W-S&rft.aulast=Moore&rft.aufirst=MD&rft.date=2009-01-01&rft.volume=11&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=AIDS+Reviews&rft.issn=11396121&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Retrovirus; RNA; Replication; Nucleocapsids; genomics; Conformation; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Safety and Immunogenicity of Multiple and Higher Doses of an Inactivated Influenza A/H5N1 Vaccine AN - 21210075; 11189460 AB - Background. H5N1 avian influenza represents an episodic zoonotic disease with the potential to cause a pandemic, and antiviral resistance is of considerable concern. We sought to generate high-titer H5N1 antibodies in healthy volunteers for the purpose of developing hyperimmune intravenous immunoglobulin. Methods. We conducted a dose-escalating, unblinded clinical trial involving 75 subjects aged 18-59 years. Three cohorts of twenty-five subjects were enrolled sequentially and received 90, 120, or 180 [mu]g of H5N1 A/Vietnam/1203/04 vaccine in 4 doses administered [image]28 days apart. Results. No statistically significant dose-related increases in the geometric mean titers (GMTs) of serum hemagglutination inhibition antibody were observed when the 90-[mu]g, 120-[mu]g, and 180-[mu]g cohorts were compared. When the cohorts were analyzed together to determine the effect of additional vaccinations, the GMTs of hemagglutination inhibition antibody after the first, second, third, and fourth vaccinations were 1:15.7, 1:22.2, 1:36.0, and 1:32.0, respectively (first vaccination vs. baseline, [image] ; second vs. first vaccination, [image] ; and third vs. second vaccination, [image]). The microneutralization GMTs after the first, second, third, and fourth vaccinations were 1:17.5, 1:33.1, 1:55.7, and 1:68.4, respectively ([image] for all comparisons). Conclusion. The results of our study suggest that a third and fourth dose of the H5N1 A/Vietnam/1203/04 vaccine may result in higher hemagglutination inhibition and microneutralization GMTs, compared with the GMTs resulting from fewer doses. There was no benefit to increasing the dose of the vaccine. Trial registration. Clinical Trials.gov identifier: JF - Journal of Infectious Diseases AU - Beigel, John H AU - Voell, Jocelyn AU - Huang, Chiung-Yu AU - Burbelo, Peter D AU - Lane, HClifford AD - National Institute of Allergy and Infectious Diseases and National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, jbeigel@niaid.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 501 EP - 508 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 4 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - vaccines KW - Intravenous administration KW - Hemagglutination inhibition KW - Influenza A KW - immunogenicity KW - Statistical analysis KW - clinical trials KW - Vaccination KW - Clinical trials KW - Vietnam KW - influenza KW - Fowl plague KW - pandemics KW - Immunogenicity KW - Vaccines KW - Immunoglobulins KW - A 01340:Antibiotics & Antimicrobials KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21210075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Safety+and+Immunogenicity+of+Multiple+and+Higher+Doses+of+an+Inactivated+Influenza+A%2FH5N1+Vaccine&rft.au=Beigel%2C+John+H%3BVoell%2C+Jocelyn%3BHuang%2C+Chiung-Yu%3BBurbelo%2C+Peter+D%3BLane%2C+HClifford&rft.aulast=Beigel&rft.aufirst=John&rft.date=2009-01-01&rft.volume=200&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Fowl plague; pandemics; Intravenous administration; Immunogenicity; Influenza A; Hemagglutination inhibition; Statistical analysis; Vaccines; Clinical trials; Vaccination; Immunoglobulins; vaccines; immunogenicity; clinical trials; influenza; Vietnam ER - TY - JOUR T1 - A Cluster of Cases of Nosocomial Legionnaires Disease Linked to a Contaminated Hospital Decorative Water Fountain AN - 21209209; 11189151 AB - Background. Nosocomial outbreaks of Legionnaires disease have been linked to contaminated water in hospitals. Immunocompromised patients are particularly vulnerable and, when infected, have a high mortality rate. We report the investigation of a cluster of cases of nosocomial pneumonia attributable to Legionella pneumophila serogroup 1 that occurred among patients on our stem cell transplantation unit. Methods. We conducted a record review to identify common points of potential exposure, followed by environmental and water sampling for Legionella species from those sources. We used an air sampler to in an attempt to detect aerosolized Legionella and pulsed-field gel electrophoresis to compare clinical and environmental isolates. Results. The most likely sources identified were the water supply in the patients' rooms and a decorative fountain in the radiation oncology suite. Samples from the patients' rooms did not grow Legionella species. Cultures of the fountain, which had been restarted 4 months earlier after being shut off for 5 months, yielded L. pneumophila serogroup 1. The isolates from both patients and the fountain were identical by pulsed-field gel electrophoresis. Both patients developed pneumonia within 10 days of completing radiation therapy, and each reported having observed the fountain at close range. Both patients' infections were identified early and treated promptly, and both recovered. Conclusions. This cluster was caused by contamination of a decorative fountain despite its being equipped with a filter and ozone generator. Fountains are a potential source of nosocomial Legionnaires disease despite standard maintenance and sanitizing measures. In our opinion, fountains present unacceptable risk in hospitals serving immunocompromised patients. JF - Infection Control and Hospital Epidemiology AU - Palmore, Tara N AU - Stock, Frida AU - White, Margaret AU - Bordner, MaryAnn AU - Michelin, Angela AU - Bennett, John E AU - Murray, Patrick R AU - Henderson, David K AD - Warren Grant Magnusen Clinical Center and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., tpalmore@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 764 EP - 768 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 8 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Health & Safety Science Abstracts KW - Contamination KW - Cell culture KW - Oncology KW - Water supplies KW - Radiation KW - Air sampling KW - Vulnerability KW - Ozone KW - outbreaks KW - Immunocompromised hosts KW - vulnerability KW - Pneumonia KW - Hospitals KW - Legionella pneumophila KW - Water sampling KW - Infection KW - infection KW - water pollution KW - Radiation therapy KW - Mortality KW - Electrophoresis KW - stem cell transplantation KW - Samplers KW - Maintenance KW - Legionnaire's disease KW - Water pollution KW - Filters KW - Reviews KW - Pulsed-field gel electrophoresis KW - Outbreaks KW - J 02420:Plant Diseases KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21209209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Cluster+of+Cases+of+Nosocomial+Legionnaires+Disease+Linked+to+a+Contaminated+Hospital+Decorative+Water+Fountain&rft.au=Palmore%2C+Tara+N%3BStock%2C+Frida%3BWhite%2C+Margaret%3BBordner%2C+MaryAnn%3BMichelin%2C+Angela%3BBennett%2C+John+E%3BMurray%2C+Patrick+R%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=8&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F598855 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Water sampling; Contamination; stem cell transplantation; Oncology; Cell culture; Infection; Samplers; Water supplies; Filters; Radiation; Immunocompromised hosts; Pulsed-field gel electrophoresis; Pneumonia; Ozone; Hospitals; Radiation therapy; Electrophoresis; outbreaks; Water pollution; Legionnaire's disease; Maintenance; Reviews; Air sampling; infection; vulnerability; Vulnerability; Outbreaks; water pollution; Legionella pneumophila DO - http://dx.doi.org/10.1086/598855 ER - TY - JOUR T1 - A Point Mutation in the agr Locus rather than Expression of the Panton-Valentine Leukocidin Caused Previously Reported Phenotypes in Staphylococcus aureus Pneumonia and Gene Regulation AN - 21206065; 11189485 AB - sThe role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S. aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by earlier investigators. In agreement with other studies that failed to detect similar effects of PVL using community-associated methicillin-resistant S. aureus strains, we found no significant effect of PVL on gene expression or pathogenesis after we repaired the mutation. These findings provide further evidence that PVL does not have a major impact on S. aureus pathogenesis. Moreover, our results demonstrate that a single nucleotide polymorphism in an intergenic region can dramatically affect bacterial physiology and virulence. Finally, our work emphasizes the need to frequently evaluate the integrity of the S. aureus agr locus. JF - Journal of Infectious Diseases AU - Villaruz, Amer E AU - Wardenburg, Juliane Bubeck AU - Khan, Burhan A AU - Whitney, Adeline R AU - Sturdevant, Daniel E AU - Gardner, Donald J AU - DeLeo, Frank R AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, motto@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 724 EP - 734 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 5 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Promoters KW - leukocidin KW - Single-nucleotide polymorphism KW - Gene regulation KW - Drug resistance KW - Point mutation KW - Staphylococcus aureus KW - Pneumonia KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - N 14845:Miscellaneous KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21206065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=A+Point+Mutation+in+the+agr+Locus+rather+than+Expression+of+the+Panton-Valentine+Leukocidin+Caused+Previously+Reported+Phenotypes+in+Staphylococcus+aureus+Pneumonia+and+Gene+Regulation&rft.au=Villaruz%2C+Amer+E%3BWardenburg%2C+Juliane+Bubeck%3BKhan%2C+Burhan+A%3BWhitney%2C+Adeline+R%3BSturdevant%2C+Daniel+E%3BGardner%2C+Donald+J%3BDeLeo%2C+Frank+R%3BOtto%2C+Michael&rft.aulast=Villaruz&rft.aufirst=Amer&rft.date=2009-01-01&rft.volume=200&rft.issue=5&rft.spage=724&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F604728 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Virulence; Promoters; leukocidin; Single-nucleotide polymorphism; Drug resistance; Gene regulation; Point mutation; Pneumonia; Staphylococcus aureus DO - http://dx.doi.org/10.1086/604728 ER - TY - JOUR T1 - Interleukin-2 cycling causes transient increases in high-sensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels AN - 21077976; 11087108 AB - Objective: To determine the effects of interleukin (IL)-2 treatment on inflammatory and thrombotic biomarkers in chronically HIV-infected adults receiving antiretroviral therapy. Methods: Cryopreserved plasma was evaluated retrospectively for C-reactive protein (CRP) and D-dimer at baseline, end of an IL-2 cycle, and long-term follow up from two randomized, controlled trials: 57 IL-2-naive adults receiving either three to six cycles of IL-2 as well as antiretroviral therapy (nucleoside analogues) or antiretroviral therapy alone for 12 months, and 40 IL-2-experienced adults on highly active antiretroviral therapy who either interrupted or continued therapy for 6 months after a baseline IL-2 cycle. High-sensitivity CRP (hsCRP) was measured by immunonephelometry (detection limit 0.175 mg/l) and D-dimer by latex agglutination (detection limit0.20 mg/l). Median within-group differences and pre and post-IL-2 changes between groups were assessed via nonparametric Wilcoxon signed-rank and Mann-Whitney U-tests. Spearman's rank test was used to assess correlations between changes in hsCRP, D-dimer, and HIV-RNA viral load. Results: Significant increases in hsCRP (study 1: 138.6 mg/l; study 2: 58.9 mg/l) and D-dimer (study 1:3.1 mg/l; study 2: 0.4 mg/l, all P < 0.0001) occurred by the end of the initial IL-2 cycle, returning to baseline by the end of study. No correlations were seen between changes in hsCRP or D-dimer and HIV-RNA, CD4 T-cell count, or proliferation (Ki67 expression). No thrombotic or cardiovascular serious adverse events occurred during these study periods. Conclusion: IL-2 dosing caused transient increases in plasma hsCRP and D-dimer levels, regardless of HIV-RNA viral load, suggesting the possibility of increased risk for thrombotic events. JF - AIDS AU - Porter, BO AU - Shen, J AU - Kovacs, JA AU - Davey, R T AU - Rehm, C AU - Lozier, J AU - Csako, G AU - Nghiem, K AU - Costello, R AU - Lane, H C AU - Sereti, I AD - National Institutes of Health, Building 10, Clinical Center, Room 11B07A, 10 Center Drive, Bethesda, MD 20892, USA, isereti@niaid.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 2015 EP - 2019 VL - 23 IS - 15 SN - 0269-9370, 0269-9370 KW - HIV KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Bioindicators KW - Acquired immune deficiency syndrome KW - Interleukin 2 KW - Latex agglutination KW - clinical trials KW - Antiretroviral agents KW - Clinical trials KW - biomarkers KW - Cryopreservation KW - Inflammation KW - nucleoside analogs KW - CD4 antigen KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - antiretroviral agents KW - Lymphocytes T KW - Proteins KW - Side effects KW - C-reactive protein KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21077976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Interleukin-2+cycling+causes+transient+increases+in+high-sensitivity+C-reactive+protein+and+D-dimer+that+are+not+associated+with+plasma+HIV-RNA+levels&rft.au=Porter%2C+BO%3BShen%2C+J%3BKovacs%2C+JA%3BDavey%2C+R+T%3BRehm%2C+C%3BLozier%2C+J%3BCsako%2C+G%3BNghiem%2C+K%3BCostello%2C+R%3BLane%2C+H+C%3BSereti%2C+I&rft.aulast=Porter&rft.aufirst=BO&rft.date=2009-01-01&rft.volume=23&rft.issue=15&rft.spage=2015&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988004-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - nucleoside analogs; CD4 antigen; Interleukin 2; highly active antiretroviral therapy; Latex agglutination; Lymphocytes T; Cryopreservation; biomarkers; Inflammation; C-reactive protein; Bioindicators; Acquired immune deficiency syndrome; antiretroviral agents; Proteins; clinical trials; Clinical trials; Antiretroviral agents; Side effects; Human immunodeficiency virus DO - http://dx.doi.org/10.1097/QAD.0b013e32832d72c6 ER - TY - JOUR T1 - Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy? AN - 20797375; 10885500 AB - Introduction Experimental streptococcal cell wall (SCW)-induced arthritis is characterized by two successive phases of the disease. The acute phase occurs early and is associated with an inflammatory process and neutrophil infiltration into the synovium. The second chronic phase is related to effector T-cell activation and the dysregulation of macrophage function. Creation of an immunomodulatory environment has been attributed to apoptotic cells themselves, apoptotic cell uptake by phagocytes as well as a less sensibility of phagocytes capturing apoptotic bodies to activation. Therefore we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats. Methods Rat apoptotic thymocytes were injected intraperitoneally (2 x 10 super(8)) in addition to an arthritogenic dose of systemic SCW in LEW female rats. Control rats received SCW immunization and PBS. Rats were then followed for arthritis occurrence and circulating cytokine detection. At sacrifice, regulatory T cells (Tregs) and macrophages were analyzed. Results Apoptotic cell injection profoundly suppressed joint swelling and destruction typically observed during the acute and chronic phases of SCW-induced arthritis. Synovial inflammatory cell infiltration and bone destruction were also markedly suppressed. Ex vivo experiments revealed reduced levels of TNF in cultures of macrophages from rats challenged with SCW in the presence of apoptotic thymocytes as well as reduced macrophage response to lipopolysaccharide. Moreover, apoptotic cell injection induced higher Foxp3+ Tregs in the lymphoid organs, especially in the draining lymph nodes. Conclusions Our data indicate that apoptotic cells modulate macrophage function and result in Treg generation/increase. This may be involved in inhibition of inflammation and amelioration of arthritis. This highlights and confirms previous studies showing that in vivo generation of Tregs using apoptotic cell injection may be a useful tool to prevent and treat inflammatory autoimmune responses. JF - Arthritis Research & Therapy AU - Perruche, S AU - Saas, P AU - Chen, W AD - Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1 VL - 11 IS - 4 SN - 1478-6354, 1478-6354 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Immunoregulation KW - Apoptosis KW - Synovium KW - Tumor necrosis factor KW - Joint diseases KW - Cell culture KW - Immunomodulation KW - Cell activation KW - Phagocytes KW - Foxp3 protein KW - Arthritis KW - Lymphocytes T KW - Cytokines KW - Lipopolysaccharides KW - Streptococcus KW - Data processing KW - Leukocytes (neutrophilic) KW - Immunization KW - Lymph nodes KW - Inflammation KW - Bone loss KW - Thymocytes KW - Cell walls KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20797375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Apoptotic+cell-mediated+suppression+of+streptococcal+cell+wall-induced+arthritis+is+associated+with+alteration+of+macrophage+function+and+local+regulatory+T-cell+increase%3A+a+potential+cell-based+therapy%3F&rft.au=Perruche%2C+S%3BSaas%2C+P%3BChen%2C+W&rft.aulast=Perruche&rft.aufirst=S&rft.date=2009-01-01&rft.volume=11&rft.issue=4&rft.spage=R104&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2750 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Macrophages; Immunoregulation; Data processing; Apoptosis; Synovium; Tumor necrosis factor; Leukocytes (neutrophilic); Joint diseases; Cell culture; Immunomodulation; Lymph nodes; Immunization; Inflammation; Cell activation; Foxp3 protein; Phagocytes; Arthritis; Bone loss; Lymphocytes T; Lipopolysaccharides; Cytokines; Thymocytes; Cell walls; Streptococcus DO - http://dx.doi.org/10.1186/ar2750 ER - TY - JOUR T1 - The SaeR/S Gene Regulatory System Is Essential for Innate Immune Evasion by Staphylococcus aureus AN - 20756349; 10190602 AB - Methicillin-resistant Staphylococcus aureus is problematic both in hospitals and in the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S 2-component gene regulatory system and studied its role in mouse models of pathogenesis and during human neutrophil interaction. In this study, we demonstrate that saeR/S plays a distinct role in S. aureus pathogenesis and is vital for virulence of MW2 in a mouse model of sepsis. Moreover, deletion of saeR/S significantly impaired survival of MW2 in human blood and after neutrophil phagocytosis. Microarray analysis revealed that SaeR/S of MW2 influences expression of a wide variety of genes with diverse biological functions. These data provide new insight into how virulence is regulated in S. aureus and associates a specific staphylococcal gene-regulatory system with invasive staphylococcal disease. JF - Journal of Infectious Diseases AU - Voyich, Jovanka M AU - Vuong, Cuong AU - DeWald, Mark AU - Nygaard, Tyler K AU - Kocianova, Stanislava AU - Griffith, Shannon AU - Jones, Jennifer AU - Iverson, Courtney AU - Sturdevant, Daniel E AU - Braughton, Kevin R AU - Whitney, Adeline R AU - Otto, Michael AU - DeLeo, Frank R AD - Department of Veterinary Molecular Biology, Montana State University, Bozeman, and Laboratory of Human Bacterial Pathogenesis and Genomics Unit, Research Technologies Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, jovanka@montana.edu Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1698 EP - 1706 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 11 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Immunology Abstracts KW - Cell survival KW - Deletion mutant KW - Data processing KW - Drug resistance KW - Leukocytes (neutrophilic) KW - Animal models KW - Virulence KW - Blood KW - Sepsis KW - Gene regulation KW - S gene KW - Staphylococcus aureus KW - Phagocytosis KW - Hospitals KW - J 02410:Animal Diseases KW - G 07870:Mammals KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20756349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=The+SaeR%2FS+Gene+Regulatory+System+Is+Essential+for+Innate+Immune+Evasion+by+Staphylococcus+aureus&rft.au=Voyich%2C+Jovanka+M%3BVuong%2C+Cuong%3BDeWald%2C+Mark%3BNygaard%2C+Tyler+K%3BKocianova%2C+Stanislava%3BGriffith%2C+Shannon%3BJones%2C+Jennifer%3BIverson%2C+Courtney%3BSturdevant%2C+Daniel+E%3BBraughton%2C+Kevin+R%3BWhitney%2C+Adeline+R%3BOtto%2C+Michael%3BDeLeo%2C+Frank+R&rft.aulast=Voyich&rft.aufirst=Jovanka&rft.date=2009-01-01&rft.volume=199&rft.issue=11&rft.spage=1698&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F598967 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Cell survival; Data processing; Deletion mutant; Drug resistance; Animal models; Leukocytes (neutrophilic); Virulence; Blood; Sepsis; Gene regulation; S gene; Phagocytosis; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1086/598967 ER - TY - JOUR T1 - The MUC1 oncoprotein as a functional target: Immunotoxin binding to alpha / beta junction mediates cell killing AN - 20628111; 9356006 AB - MUC1, a heavily glycosylated mucin, has generated considerable interest as a target for tumor killing because of its overexpression in malignancies. Full-length MUC1 (MUC1/TM) is proteolytically cleaved after synthesis generating and subunits, which specifically bind in a noncovalent interaction. Although the chain remains on the cell surface, the chain binds in an on-and-off interaction. Most anti-MUC1 antibodies (Abs) described to date recognize epitopes within the highly immunogenic -chain tandem repeat. Because the -chain is shed, such Abs are sequestered and fail to reach MUC1-expressing cells. Immunizing with cDNA encoding MUC1/TM and the spliced MUC1/X isoform from which the tandem repeat has been deleted yielded antibodies to the MUC1 / junction. Pseudomonas toxin PE38 linked to polyclonal anti-MUC1 / junction Abs both bound and killed MUC1-positive malignant cells. Monoclonal DMC209 binds the MUC1 / junction in both MUC1/X and MUC1/TM. When injected into SCID mice xenotransplanted with human breast cancer MDA-MB-231, monoclonal DMC209 showed significant in vivo tumor-suppressive activity. The MUC1/X / junction presents a biologically-significant target in MUC1-expressing malignancies because (i) antibodies directed against cell-bound / junction epitopes reach the intended cellular target, (ii) antibodies to junction epitope are internalized into cells, (iii) anti / junction antibodies can effectively kill high MUC1-expressing cancer cells as antibody-toxin conjugates and (iv) antibodies targeting the MUC1 cell-bound / junction results in tumor suppression in vivo. Our results indicate that cell-bound MUC1 / junction, unlike shed alpha chain, represents a highly effective moiety for targeting and killing MUC1-expressing malignancies. JF - International Journal of Cancer AU - Rubinstein, Daniel B AU - Karmely, Maya AU - Pichinuk, Edward AU - Ziv, Ravit AU - Benhar, Itai AU - Feng, Ningping AU - Smorodinsky, Nechama I AU - Wreschner, Daniel H AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, danielhw@post.tau.ac.il Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 46 EP - 54 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 1 SN - 0020-7136, 0020-7136 KW - Microbiology Abstracts B: Bacteriology; Oncogenes & Growth Factors Abstracts; Immunology Abstracts KW - Cell surface KW - Antibodies KW - Malignancy KW - Immunogenicity KW - mucin KW - Breast cancer KW - Pseudomonas KW - Tumors KW - Epitopes KW - Immunotoxins KW - Toxins KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - J 02350:Immunology KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20628111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Neural+and+cardiac+toxicities+associated+with+3%2C4-methylenedioxymethamphetamine+%28MDMA%29.&rft.au=Baumann%2C+Michael+H%3BRothman%2C+Richard+B&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988010-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell surface; Malignancy; Antibodies; Immunogenicity; mucin; Breast cancer; Tumors; Toxins; Immunotoxins; Epitopes; Pseudomonas DO - http://dx.doi.org/10.1002/ijc.23910 ER - TY - JOUR T1 - Serum pepsinogens and risk of esophageal squamous dysplasia AN - 20627474; 9356061 AB - Pepsinogens are a class of endopeptidases that are secreted by the gastric epithelium and released into the circulation. Low serum pepsinogen I (PGI) and low serum pepsinogen I/pepsinogen II ratio (PGI/II ratio) are markers of gastric fundic atrophy, and have recently been shown to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). We conducted the current study to test whether these markers are also associated with esophageal squamous dysplasia (ESD), the precursor lesion of ESCC. We measured serum PGI and PGII, using enzyme-linked immunosorbent assays, in 125 case subjects (patients with moderate or severe ESD) and 250 sex-matched control subjects (no ESD) selected from an endoscopic screening study in Linxian, China. We used conditional logistic regression models adjusted for age, smoking and place of residence to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Serum PGI showed no statistically significant association with ESD, whether analyzed as a dichotomous, ordinal (quartiles) or continuous variable. Lower serum PGI/II ratio, however, showed a dose-response association with increased risk of ESD, with an adjusted OR (95% CI) of 2.12 (1.08-4.18), comparing the lowest versus the highest quartile. The association between the lower serum PGI/II ratio and log OR of ESD was nearly linear, and the p-value for the continuous association was 0.03. Lower serum PGI/II ratio was linearly associated with higher risk of ESD. This result is consistent with recent findings that gastric atrophy may increase the risk of ESCC. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Kamangar, Farin AU - Diaw, Lena AU - Wei, Wen-Qiang AU - Abnet, Christian C AU - Wang, Guo-Qing AU - Roth, Mark J AU - Liu, Bing AU - Lu, Ning AU - Giffen, Carol AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, kamangaf@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 456 EP - 460 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 2 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Smoking KW - Age KW - Dose-response effects KW - Lesions KW - China, People's Rep. KW - medical instruments KW - Immunoassays KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20627474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Serum+pepsinogens+and+risk+of+esophageal+squamous+dysplasia&rft.au=Kamangar%2C+Farin%3BDiaw%2C+Lena%3BWei%2C+Wen-Qiang%3BAbnet%2C+Christian+C%3BWang%2C+Guo-Qing%3BRoth%2C+Mark+J%3BLiu%2C+Bing%3BLu%2C+Ning%3BGiffen%2C+Carol%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2009-01-01&rft.volume=124&rft.issue=2&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23918 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Age; Dose-response effects; Lesions; medical instruments; Immunoassays; Cancer; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.23918 ER - TY - JOUR T1 - A prospective study of loss of control eating for body weight gain in children at high risk for adult obesity AN - 20556254; 9268159 AB - Objective Limited data suggest that disordered-eating may predispose children to excessive weight gain. We investigated the relationship between baseline responses to the Eating Disorder Examination adapted for Children (ChEDE) and change in BMI (kg/m2) in children at high risk for adult obesity. Method Children (6-12 years) were administered the ChEDE to assess loss of control (LOC) eating, dietary restraint, and eating, shape, and weight concern. Height and weight were measured at baseline and annually. Results Between July, 1999, and August, 2007, 772 measurements were obtained from 143 children over 4.5 ± 1.9 years. LOC eating predicted an increased rate of BMI growth over time (p = .02). Compared with children without LOC, those reporting LOC gained an additional mean 2.4 kg of weight per year. Conclusion LOC is a salient predictor of weight gain during middle childhood. Interventions that decrease LOC eating should be evaluated for their ability to prevent excessive pediatric weight gain. JF - International Journal of Eating Disorders AU - Tanofsky-Kraff, Marian AU - Yanovski, Susan Z AU - Schvey, Natasha A AU - Olsen, Cara H AU - Gustafson, Jennifer AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), DHHS, Bethesda, Maryland, mtanofsky@usuhs.edu Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 26 EP - 30 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 42 IS - 1 SN - 0276-3478, 0276-3478 KW - Physical Education Index; Risk Abstracts KW - Diets KW - Measurement KW - Obesity KW - Eating disorders KW - Body mass KW - obesity KW - Diet (weight control) KW - Height KW - Adults KW - Children KW - eating disorders KW - intervention KW - Objectives KW - body weight KW - R2 23110:Psychological aspects KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20556254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Eating+Disorders&rft.atitle=A+prospective+study+of+loss+of+control+eating+for+body+weight+gain+in+children+at+high+risk+for+adult+obesity&rft.au=Tanofsky-Kraff%2C+Marian%3BYanovski%2C+Susan+Z%3BSchvey%2C+Natasha+A%3BOlsen%2C+Cara+H%3BGustafson%2C+Jennifer%3BYanovski%2C+Jack+A&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2009-01-01&rft.volume=42&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Eating+Disorders&rft.issn=02763478&rft_id=info:doi/10.1002%2Feat.20580 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Measurement; Eating disorders; Objectives; Body mass; Diet (weight control); Height; Adults; Children; Diets; eating disorders; intervention; obesity; body weight DO - http://dx.doi.org/10.1002/eat.20580 ER - TY - JOUR T1 - Crystallization and preliminary X-ray diffraction analyses of several forms of the CfaB major subunit of enterotoxigenic Escherichia coli CFA/I fimbriae AN - 20548261; 9256686 AB - Enterotoxigenic Escherichia coli (ETEC), a major global cause of diarrhea, initiates the pathogenic process via fimbriae-mediated attachment to the small intestinal epithelium. A common prototypic ETEC fimbria, colonization factor antigen I (CFA/I), consists of a tip-localized minor adhesive subunit CfaE and the stalk-forming major subunit CfaB, both of which are necessary for fimbrial assembly. To elucidate the structure of CFA/I at atomic resolution, three recombinant proteins were generated consisting of fusions of the minor and major subunits (CfaEB) and of two (CfaBB) and three (CfaBBB) repeats of the major subunit. Crystals of CfaEB diffracted X-rays to 2.1Aa resolution and displayed the symmetry of space group P21. CfaBB exhibited a crystal diffraction limit of 2.3Aa resolution and had the symmetry of space group P21212. CfaBBB crystallized in the monoclinic space group C2 and diffracted X-rays to 2.3Aa resolution. These structures were determined using the molecular-replacement method. JF - Acta Crystallographica Section F AU - Li, Yong-Fu AU - Poole, Steven AU - Rasulova, Fatima AU - McVeigh, Annette L AU - Savarino, Stephen J AU - Xia, Di AD - aLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4256, USA, dixia@helix.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 242 EP - 247 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 65 IS - 3 SN - 1744-3091, 1744-3091 KW - Microbiology Abstracts B: Bacteriology KW - colonization factor antigen I fimbriae KW - CfaB subunit KW - enterotoxigenic Escherichia coli KW - Crystallization KW - Diarrhea KW - Crystals KW - X-ray diffraction KW - Pili KW - Ionizing radiation KW - Escherichia coli KW - Intestine KW - Epithelium KW - Adhesives KW - Fimbria KW - Colonization factor KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20548261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+F&rft.atitle=Crystallization+and+preliminary+X-ray+diffraction+analyses+of+several+forms+of+the+CfaB+major+subunit+of+enterotoxigenic+Escherichia+coli+CFA%2FI+fimbriae&rft.au=Li%2C+Yong-Fu%3BPoole%2C+Steven%3BRasulova%2C+Fatima%3BMcVeigh%2C+Annette+L%3BSavarino%2C+Stephen+J%3BXia%2C+Di&rft.aulast=Li&rft.aufirst=Yong-Fu&rft.date=2009-01-01&rft.volume=65&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+F&rft.issn=17443091&rft_id=info:doi/10.1107%2FS1744309109001584 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Crystallization; Diarrhea; Pili; Ionizing radiation; Intestine; Epithelium; Crystals; Adhesives; X-ray diffraction; Colonization factor; Escherichia coli; Fimbria DO - http://dx.doi.org/10.1107/S1744309109001584 ER - TY - JOUR T1 - The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations AN - 20525737; 9210011 AB - The realization that there exists a multimembered family of cation channels with structural similarity to Drosophila's Trp channel emerged during the second half of the 1990s. In mammals, depending on the species, the TRP family counts 29 or 30 members which has been subdivided into 6 subfamilies on the basis of sequence similarity. TRP channels are nonselective monovalent cation channels, most of which also allow passage of Ca super(2+). Many members of each of these families, but not all, are involved in sensory signal transduction. The C-type (for canonical or classical) subfamily, differs from the other TRP subfamilies in that it fulfills two different types of function: membrane depolarization, resembling sensory transduction TRPs, and mediation of sustained increases in intracellular Ca super(2+). The mechanism(s) by which the C-class of TRP channels-the TRPCs-are activated is poorly understood and their role in mediating intracellular Ca super(2+) increases is being questioned. Both of these questions-mechanism of activation and participation in Ca super(2+) entry-are the topics of this review. JF - Annual Review of Pharmacology and Toxicology AU - Birnbaumer, Lutz AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, birnbau1@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 395 EP - 426 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 49 SN - 0362-1642, 0362-1642 KW - Entomology Abstracts; Calcium & Calcified Tissue Abstracts; Toxicology Abstracts KW - cation channels KW - Calcium KW - Reviews KW - Ion channels KW - transient receptor potential proteins KW - sensory transduction KW - Drosophila KW - Calcium (intracellular) KW - Signal transduction KW - Membrane potential KW - Depolarization KW - Z 05300:General KW - X 24310:Pharmaceuticals KW - T 2000:Cellular Calcium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20525737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Pharmacology+and+Toxicology&rft.atitle=The+TRPC+Class+of+Ion+Channels%3A+A+Critical+Review+of+Their+Roles+in+Slow%2C+Sustained+Increases+in+Intracellular+Ca2%2B+Concentrations&rft.au=Birnbaumer%2C+Lutz&rft.aulast=Birnbaumer&rft.aufirst=Lutz&rft.date=2009-01-01&rft.volume=49&rft.issue=&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Pharmacology+and+Toxicology&rft.issn=03621642&rft_id=info:doi/10.1146%2Fannurev.pharmtox.48.113006.094928 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - cation channels; Calcium; Reviews; Ion channels; sensory transduction; transient receptor potential proteins; Depolarization; Membrane potential; Signal transduction; Calcium (intracellular); Drosophila DO - http://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094928 ER - TY - JOUR T1 - Cancer Screening: The Clash of Science and Intuition AN - 20525618; 9209921 AB - The concept of early detection of cancer holds great promise and intuitive appeal. However, powerful biases can mislead clinicians when evaluating the efficacy of screening tests by clinical observation alone. Selection bias, lead-time bias, length-biased sampling, and overdiagnosis are counterintuitive concepts with critical implications for early-detection efforts. This article explains these biases and other common confounders in cancer screening. The most direct and reliable way to avoid being led astray by intuitions is through the use of randomized controlled trials. JF - Annual Review of Medicine AU - Kramer, Barnett S AU - Croswell, Jennifer Miller AD - Office of Disease Prevention, Office of the Director, National Institutes of Health, Bethesda, Maryland 20892, bk76p@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 125 EP - 137 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 60 SN - 0066-4219, 0066-4219 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Sampling KW - Clinical trials KW - Cancer KW - Lead KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20525618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=Cancer+Screening%3A+The+Clash+of+Science+and+Intuition&rft.au=Kramer%2C+Barnett+S%3BCroswell%2C+Jennifer+Miller&rft.aulast=Kramer&rft.aufirst=Barnett&rft.date=2009-01-01&rft.volume=60&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.60.101107.134802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reviews; Sampling; Clinical trials; Lead; Cancer DO - http://dx.doi.org/10.1146/annurev.med.60.101107.134802 ER - TY - JOUR T1 - Gene by Environment Interaction in Asthma AN - 20523682; 9209898 AB - Marked international differences in rates of asthma and allergies and the importance of family history highlight the primacy of interactions between genetic variation and the environment in asthma etiology. Environmental tobacco smoke (or secondhand smoke), ambient air pollutants, and endotoxin and/or other pathogen-associated molecular patterns are the ambient exposures studied most frequently for interactions with genetic polymorphisms in asthma. To date, results from the literature remain inconclusive. Most published studies are underpowered to study interactions between genetic polymorphisms and ambient exposures, each with weak effects. Strategies to increase power include cooperation across studies to increase sample sizes and improve measures of both exposure and asthma phenotypes. Genome-wide association studies hold promise for identifying unexpected gene environment interactions, but given the statistical power issues, candidate gene association studies will remain important. New tools are enabling the study of epigenetic mechanisms for environmental interactions. JF - Annual Review of Public Health AU - London, Stephanie J AU - Romieu, Isabelle AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, london2@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 55 EP - 80 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 30 SN - 0163-7525, 0163-7525 KW - Genetics Abstracts; Pollution Abstracts; Immunology Abstracts KW - Air pollution KW - Allergies KW - Asthma KW - Cooperation KW - Endotoxins KW - Etiology KW - Gene polymorphism KW - Genetic diversity KW - Genetics KW - Hypersensitivity KW - Passive smoking KW - Pollutants KW - Public health KW - Respiratory diseases KW - Reviews KW - Smoke KW - Statistics KW - Tobacco KW - epigenetics KW - genetic diversity KW - P 0000:AIR POLLUTION KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20523682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Public+Health&rft.atitle=Gene+by+Environment+Interaction+in+Asthma&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Public+Health&rft.issn=01637525&rft_id=info:doi/10.1146%2Fannurev.publhealth.031308.100151 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Endotoxins; Etiology; Statistics; Gene polymorphism; Cooperation; Asthma; Genetic diversity; Public health; Smoke; Hypersensitivity; Pollutants; epigenetics; Reviews; Tobacco; Air pollution; Genetics; Passive smoking; genetic diversity; Respiratory diseases; Allergies DO - http://dx.doi.org/10.1146/annurev.publhealth.031308.100151 ER - TY - JOUR T1 - The HapMap and Genome-Wide Association Studies in Diagnosis and Therapy AN - 20523645; 9209944 AB - The International HapMap Project produced a genome-wide database of human genetic variation for use in genetic association studies of common diseases. The initial output of these studies has been overwhelming, with over 150 risk loci identified in studies of more than 60 common diseases and traits. These associations have suggested previously unsuspected etiologic pathways for common diseases that will be of use in identifying new therapeutic targets and developing targeted interventions based on genetically defined risk. Here we examine the development and application of the HapMap to genome-wide association (GWA) studies; present and future technologies for GWA research; current major efforts in GWA studies; successes and limitations of the GWA approach in identifying polymorphisms related to complex diseases; data release and privacy polices; use of these findings by clinicians, the public, and academic physicians; and sources of ongoing authoritative information on this rapidly evolving field. JF - Annual Review of Medicine AU - Manolio, Teri A AU - Collins, Francis S AD - National Human Genome Research Institute, Bethesda, Maryland 20892, manolio@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 443 EP - 456 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 60 SN - 0066-4219, 0066-4219 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Databases KW - Data processing KW - Reviews KW - Genetic diversity KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20523645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=The+HapMap+and+Genome-Wide+Association+Studies+in+Diagnosis+and+Therapy&rft.au=Manolio%2C+Teri+A%3BCollins%2C+Francis+S&rft.aulast=Manolio&rft.aufirst=Teri&rft.date=2009-01-01&rft.volume=60&rft.issue=&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.60.061907.093117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Reviews; Genetic diversity DO - http://dx.doi.org/10.1146/annurev.med.60.061907.093117 ER - TY - JOUR T1 - Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS AN - 20509142; 9199172 AB - Objectives: To determine the incidence and outcomes of intensive care unit-acquired neuromyopathy and to investigate the role of methylprednisolone in survivors of persistent acute lung injury. Design: Secondary analysis of completed randomized placebo-controlled trial. Setting: Twenty-five hospitals in the NHLBI ARDS Network. Patients and participants: Patients enrolled in the ARDS Network study of methylprednisolone versus placebo for persistent ARDS who survived 60 days or to hospital discharge. Measurements and results: One hundred and twenty-eight study patients survived 60 days. Forty-three (34%) of these patients had evidence by chart review of ICU-acquired neuromyopathy, which was associated with prolonged mechanical ventilation, return to mechanical ventilation, and delayed return to home after critical illness. Treatment with methylprednisolone was not significantly associated with an increase in risk of neuromyopathy (OR 1.5; 95% CI 0.7-3.2). Conclusions: ICU-acquired-neuromyopathy is common among survivors of persistent ARDS and is associated with poorer clinical outcomes. We did not find a significant association between methylprednisolone treatment and neuromyopathy. Limitations of this study preclude definitive conclusions about the causal relationship between corticosteroids and ICU-acquired neuromuscular dysfunction. JF - Intensive Care Medicine AU - Hough, Catherine L AU - Steinberg, Kenneth P AU - Taylor Thompson, B AU - Rubenfeld, Gordon D AU - Hudson, Leonard D AD - Department of Medicine and The NHLBI ARDS Network, University of Washington, 325 Ninth Avenue, Mailstop 359762, Seattle, WA, 98104, USA, cterrlee@u.washington.edu Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 63 EP - 68 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 VL - 35 IS - 1 SN - 0342-4642, 0342-4642 KW - Risk Abstracts KW - Ventilation KW - Injuries KW - Lung KW - secondary analysis KW - Reviews KW - corticoids KW - Hospitals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20509142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Intensive+care+unit-acquired+neuromyopathy+and+corticosteroids+in+survivors+of+persistent+ARDS&rft.au=Hough%2C+Catherine+L%3BSteinberg%2C+Kenneth+P%3BTaylor+Thompson%2C+B%3BRubenfeld%2C+Gordon+D%3BHudson%2C+Leonard+D&rft.aulast=Hough&rft.aufirst=Catherine&rft.date=2009-01-01&rft.volume=35&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-008-1304-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Injuries; Ventilation; secondary analysis; Lung; Reviews; Hospitals; corticoids DO - http://dx.doi.org/10.1007/s00134-008-1304-4 ER - TY - JOUR T1 - Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity AN - 20400879; 9076905 AB - Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of single-nucleotide polymorphisms (SNPs) on benzene-induced hematotoxicity, we analyzed 1395 SNPs in 411 genes using an Illumina GoldenGate assay in 250 benzene-exposed workers and 140 unexposed controls. Highly significant findings clustered in five genes (BLM, TP53, RAD51, WDR79 and WRN) that play a critical role in DNA repair and genomic maintenance, and these regions were then further investigated with tagSNPs. One or more SNPs in each gene were associated with highly significant 10-20% reductions (P values ranged from 0.0011 to 0.0002) in the white blood cell (WBC) count among benzene-exposed workers but not controls, with evidence for gene-environment interactions for SNPs in BLM, WRN and RAD51. Further, among workers exposed to benzene, the genotype-associated risk of having a WBC count [Lt]4000 cells/kl increased when using individuals with progressively higher WBC counts as the comparison group, with some odds ratios >>8-fold. In vitro functional studies revealed that deletion of SGS1 in yeast, equivalent to lacking BLM and WRN function in humans, caused reduced cellular growth in the presence of the toxic benzene metabolite hydroquinone, and knockdown of WRN using specific short hairpin RNA increased susceptibility of human TK6 cells to hydroquinone toxicity. Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity. JF - Carcinogenesis AU - Lan, Qing AU - Zhang, Luoping AU - Shen, Min AU - Jo, William J AU - Vermeulen, Roel AU - Li, Guilan AU - Vulpe, Christopher AU - Lim, Sophia AU - Ren, Xuefeng AU - Rappaport, Stephen M AU - Berndt, Sonja I AU - Yeager, Meredith AU - Yuenger, Jeff AU - Hayes, Richard B AU - Linet, Martha AU - Yin, Songnian AU - Chanock, Stephen AU - Smith, Martyn T AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, qingl@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 50 EP - 58 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 30 IS - 1 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Leukocytes KW - Hydroquinone KW - Metabolites KW - Toxicity KW - DNA repair KW - Benzene KW - p53 protein KW - Workers KW - RNA KW - Single-nucleotide polymorphism KW - Carcinogenesis KW - genomics KW - homologous recombination KW - N 14820:DNA Metabolism & Structure KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20400879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Large-scale+evaluation+of+candidate+genes+identifies+associations+between+DNA+repair+and+genomic+maintenance+and+development+of+benzene+hematotoxicity&rft.au=Lan%2C+Qing%3BZhang%2C+Luoping%3BShen%2C+Min%3BJo%2C+William+J%3BVermeulen%2C+Roel%3BLi%2C+Guilan%3BVulpe%2C+Christopher%3BLim%2C+Sophia%3BRen%2C+Xuefeng%3BRappaport%2C+Stephen+M%3BBerndt%2C+Sonja+I%3BYeager%2C+Meredith%3BYuenger%2C+Jeff%3BHayes%2C+Richard+B%3BLinet%2C+Martha%3BYin%2C+Songnian%3BChanock%2C+Stephen%3BSmith%2C+Martyn+T%3BRothman%2C+Nathaniel&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn249 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hydroquinone; Leukocytes; Metabolites; Toxicity; DNA repair; Benzene; p53 protein; Workers; RNA; Single-nucleotide polymorphism; Carcinogenesis; genomics; homologous recombination DO - http://dx.doi.org/10.1093/carcin/bgn249 ER - TY - JOUR T1 - Correspondence: Asthma and obesity: An archival addendum AN - 20397448; 9068720 AB - Abstract not available. JF - Journal of Allergy and Clinical Immunology AU - Cohen, Sheldon G AD - National Institute of Allergy and Infectious Diseases and the National Library of Medicine, History of Medicine Division, National Institutes of Health, Bethesda, Md, scohen@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 265 EP - 266 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA, [mailto:membership@aaaai.org], [URL:http://www.aaai.org] VL - 123 IS - 1 SN - 0091-6749, 0091-6749 KW - Physical Education Index KW - Obesity KW - Immune system KW - Asthma KW - Allergies KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Correspondence%3A+Asthma+and+obesity%3A+An+archival+addendum&rft.au=Cohen%2C+Sheldon+G&rft.aulast=Cohen&rft.aufirst=Sheldon&rft.date=2009-01-01&rft.volume=123&rft.issue=1&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2008.07.038 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Immune system; Asthma; Allergies DO - http://dx.doi.org/10.1016/j.jaci.2008.07.038 ER - TY - JOUR T1 - Direct and Indirect Impairment of Human Dendritic Cell Function by Virulent Francisella tularensis Schu S4 AN - 20383919; 9065249 AB - The gram-negative, facultative intracellular bacterium Francisella tularensis causes acute, lethal pneumonic disease following infection with only 10 CFU. The mechanisms used by the bacterium to accomplish this in humans are unknown. Here, we demonstrate that virulent, type A F. tularensis strain Schu S4 efficiently infects and replicates in human myeloid dendritic cells (DCs). Despite exponential replication over time, Schu S4 failed to stimulate transforming growth factor b, interleukin-10 (IL-10), IL-6, IL-1b, IL-12, tumor necrosis factor alpha, alpha interferon (IFN-a), and IFN-b throughout the course of infection. Schu S4 also suppressed the ability of directly infected DCs to respond to different Toll-like receptor agonists. Furthermore, we also observed functional inhibition of uninfected bystander cells. This inhibition was mediated, in part, by a heat-stable bacterial component. Lipopolysaccharide (LPS) from Schu S4 was present in Schu S4-conditioned medium. However, Schu S4 LPS was weakly inflammatory and failed to induce suppression of DCs at concentrations below 10 kg/ml, and depletion of Schu S4 LPS did not significantly alleviate the inhibitory effect of Schu S4-conditioned medium in uninfected human DCs. Together, these data show that type A F. tularensis interferes with the ability of a central cell type of the immune system, DCs, to alert the host of infection both intra- and extracellularly. This suggests that immune dysregulation by F. tularensis operates on a broader and more comprehensive scale than previously appreciated. JF - Infection and Immunity AU - Chase, Jennifer C AU - Celli, Jean AU - Bosio, Catharine M AD - Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 180 EP - 195 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Data processing KW - Replication KW - Immune system KW - Interleukin 1 KW - Francisella tularensis KW - Tumor necrosis factor-a KW - Infection KW - Interleukin 10 KW - Inflammation KW - b-Interferon KW - Interleukin 12 KW - Dendritic cells KW - Colony-forming cells KW - Transforming growth factor-b KW - Lipopolysaccharides KW - Thermal stability KW - Toll-like receptors KW - a-Interferon KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20383919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Direct+and+Indirect+Impairment+of+Human+Dendritic+Cell+Function+by+Virulent+Francisella+tularensis+Schu+S4&rft.au=Chase%2C+Jennifer+C%3BCelli%2C+Jean%3BBosio%2C+Catharine+M&rft.aulast=Chase&rft.aufirst=Jennifer&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Data processing; Replication; Immune system; Interleukin 1; Infection; Tumor necrosis factor-a; Interleukin 10; Inflammation; b-Interferon; Dendritic cells; Interleukin 12; Colony-forming cells; Lipopolysaccharides; Transforming growth factor-b; Thermal stability; a-Interferon; Toll-like receptors; Francisella tularensis ER - TY - JOUR T1 - Sustained Activation of Akt and Erk1/2 Is Required for Coxiella burnetii Antiapoptotic Activity AN - 20381927; 9065252 AB - Coxiella burnetii is an obligate intracellular bacterial pathogen that directs biogenesis of a lysosome-like, parasitophorous vacuole in mammalian cells. We recently reported that C. burnetii inhibits apoptotic cell death in macrophages, presumably as a mechanism to sustain the host for completion of its lengthy infectious cycle. In the current study, we further investigated C. burnetii manipulation of host cell signaling and apoptosis by examining the effect of C. burnetii infection on activation of 15 host proteins involved in stress responses, cytokine production, and apoptosis. C. burnetii infection of THP-1 human macrophage-like cells caused increased levels of phosphorylated c-Jun, Hsp27, Jun N-terminal protein kinase, and p38 at 2 h postinfection (hpi), and this activation rapidly decreased to near basal levels by 24 hpi. The prosurvival kinases Akt and Erk1/2 (extracellular signal-regulated kinases 1 and 2) were also activated at 2 to 6 hpi; however, the phosphorylation of these proteins increased coincident with C. burnetii replication through at least 72 hpi. Sustained phosphorylation of Akt and Erk1/2 was abolished by treatment of infected cells with rifampin, indicating their activation is a C. burnetii-directed event requiring pathogen RNA synthesis. Moreover, pharmacological inhibition of Akt or Erk1/2 significantly decreased C. burnetii antiapoptotic activity. Collectively, these results indicate the importance of C. burnetii modulation of host signaling and demonstrate a critical role for Akt and Erk1/2 in successful intracellular parasitism and maintenance of host cell viability. JF - Infection and Immunity AU - Voth, Daniel E AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 205 EP - 213 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Intracellular signalling KW - Apoptosis KW - Replication KW - Transcription KW - Pathogens KW - c-Jun protein KW - Infection KW - Parasitism KW - Cell activation KW - parasitophorous vacuole KW - Coxiella burnetii KW - Rifampin KW - Extracellular signal-regulated kinase KW - Phosphorylation KW - Mammalian cells KW - Hsp27 protein KW - Transcription factors KW - AKT protein KW - Protein kinase KW - Cytokines KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20381927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Sustained+Activation+of+Akt+and+Erk1%2F2+Is+Required+for+Coxiella+burnetii+Antiapoptotic+Activity&rft.au=Voth%2C+Daniel+E%3BHeinzen%2C+Robert+A&rft.aulast=Voth&rft.aufirst=Daniel&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Intracellular signalling; Apoptosis; Replication; Transcription; Pathogens; Infection; c-Jun protein; Parasitism; Cell activation; parasitophorous vacuole; Extracellular signal-regulated kinase; Rifampin; Mammalian cells; Phosphorylation; Transcription factors; Hsp27 protein; AKT protein; Cytokines; Protein kinase; Signal transduction; Coxiella burnetii ER - TY - JOUR T1 - Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers AN - 20375883; 9061822 AB - Lower molecular weight polybrominated diphenyl ethers (PBDEs), components of flame retardants, are found in the environment and in human and animal tissues. Toxicity studies were conducted in F344/N rats and B6C3F1 mice by administering a flame retardant containing these lower molecular weight PBDEs (BDE-47, BDE-99, BDE-100, and BDE153) by oral gavage 5 days/week for 13 weeks at doses of 0.01, 5, 50, 100 or 500 mg/kg/day. Liver was the primary target organ in rats and mice. Treatment-related increases in liver weights, liver cytochrome P450 (1A1, 1A2, 2B) and UDPGT (rats only) levels, and liver lesions were seen in both rats and mice. Hepatocyte hypertrophy and vacuolization increased in incidence and severity with treatment, and occurred at levels of 50 mg/kg and above in rats, and at 100 mg/kg and above in mice. Liver Cyp 1A1, 1A2, and 2B levels were increased at exposure levels of 50 mg/kg and above in rats and mice. In addition, treatment-related thyroid lesions occurred particularly in rats. The most sensitive parameter for PBDE toxicity was the increase in liver weights which occurred at 5 mg/kg above in rats and 50 mg/kg and above in mice. These results suggest that liver may be a target organ for carcinogenesis processes after long-term administration of PBDEs. A chronic PBDE study is currently being conducted by the National Toxicology Program. JF - Experimental and Toxicologic Pathology AU - Dunnick, June K AU - Nyska, Abraham AD - National Institute of Environmental Health Sciences, Research Triangle Park, P.O. Box 12233, NC 27709, USA, dunnickj@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 1 EP - 12 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 61 IS - 1 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Flame retardant KW - Polybrominated diphenyl ethers KW - Liver toxicity KW - polybrominated diphenyl ethers KW - Hypertrophy KW - Hepatocytes KW - Molecular weight KW - Carcinogenesis KW - Liver KW - Thyroid KW - Fire retardant chemicals KW - Toxicity KW - Cytochrome P450 KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20375883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=Characterization+of+liver+toxicity+in+F344%2FN+rats+and+B6C3F1+mice+after+exposure+to+a+flame+retardant+containing+lower+molecular+weight+polybrominated+diphenyl+ethers&rft.au=Dunnick%2C+June+K%3BNyska%2C+Abraham&rft.aulast=Dunnick&rft.aufirst=June&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2008.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hypertrophy; polybrominated diphenyl ethers; Hepatocytes; Molecular weight; Carcinogenesis; Thyroid; Liver; Cytochrome P450; Toxicity; Fire retardant chemicals DO - http://dx.doi.org/10.1016/j.etp.2008.06.008 ER - TY - JOUR T1 - Multiecho dixon fat and water separation method for detecting fibrofatty infiltration in the myocardium AN - 20373610; 9058293 AB - Conventional approaches for fat and water discrimination based on chemical-shift fat suppression have reduced ability to characterize fatty infiltration due to poor contrast of microscopic fat. The multiecho Dixon approach to water and fat separation has advantages over chemical-shift fat suppression: 1) water and fat images can be acquired in a single breathhold, avoiding misregistration; 2) fat has positive contrast; 3) the method is compatible with precontrast and late-enhancement imaging, 4) less susceptible to partial-volume effects, and 5) robust in the presence of background field variation; and 6) for the bandwidth implemented, chemical-shift artifact is decreased. The proposed technique was applied successfully in all 28 patients studied. This included 10 studies with indication of coronary artery disease (CAD), of which four cases with chronic myocardial infarction (MI) exhibited fatty infiltration; 13 studies to rule out arrhythmogenic right ventricular cardiomyopathy (ARVC), of which there were three cases with fibrofatty infiltration and two confirmed with ARVC; and five cases of cardiac masses (two lipomas). The precontrast contrast-to-noise ratio (CNR) of intramyocardial fat was greatly improved, by 240% relative to conventional fat suppression. For the parameters implemented, the signal-to-noise ratio (SNR) was decreased by 30% relative to conventional late enhancement. The multiecho Dixon method for fat and water separation provides a sensitive means of detecting intramyocardial fat with positive signal contrast. Magn Reson Med 61:215-221, 2009. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Hernando, Diego AU - Shah, Saurabh AU - Zuehlsdorff, Sven AU - Jerecic, Renate AU - Mancini, Christine AU - Liang, Zhi-Pei AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS), Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 215 EP - 221 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 61 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Cardiomyopathy KW - Ventricle KW - N.M.R. KW - lipoma KW - imaging KW - Myocardial infarction KW - Heart diseases KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Multiecho+dixon+fat+and+water+separation+method+for+detecting+fibrofatty+infiltration+in+the+myocardium&rft.au=Kellman%2C+Peter%3BHernando%2C+Diego%3BShah%2C+Saurabh%3BZuehlsdorff%2C+Sven%3BJerecic%2C+Renate%3BMancini%2C+Christine%3BLiang%2C+Zhi-Pei%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21657 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Cardiomyopathy; Ventricle; N.M.R.; lipoma; imaging; Myocardial infarction; Myocardium; Heart diseases DO - http://dx.doi.org/10.1002/mrm.21657 ER - TY - JOUR T1 - Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States AN - 20368472; 9054542 AB - Objective: Immunosuppression may increase risk for some skin cancers. We evaluated skin cancer epidemiology among persons with AIDS. Design: We linked data from population-based US AIDS and cancer registries to evaluate risk of nonkeratinocytic skin cancers (melanoma, Merkel cell carcinoma, and appendageal carcinomas, including sebaceous carcinoma) in 497142 persons with AIDS. Methods: Standardized incidence ratios (SIRs) were calculated to relate skin cancer risk to that in the general population. We used logistic regression to compare risk according to demographic factors, CD4 cell count, and a geographic index of ultraviolet radiation exposure. Results: From 60 months before to 60 months after AIDS onset, persons with AIDS had elevated risks of melanoma (SIR = 1.3, 95% confidence interval 1.1-1.4, n = 292 cases) and, more strongly, of Merkel cell carcinoma (SIR= 11, 95% confidence interval 6.3-17, n = 17) and sebaceous carcinoma (SIR = 8.1, 95% confidence interval 3.2-17, n = 7). Risk for appendageal carcinomas increased with progressive time relative to AIDS onset (P trend = 0.03). Risk of these skin cancers was higher in non-Hispanic whites than other racial/ethnic groups, and melanoma risk was highest among men who have sex with men. Melanoma risk was unrelated to CD4 cell count at AIDS onset (P=0.32). Risks for melanoma and appendageal carcinomas rose with increasing ultraviolet radiation exposure (P trend <10 super(-4) and P trend = 10 super(-3), respectively). Conclusion: Among persons with AIDS, there is a modest excess risk of melanoma, which is not strongly related to immunosuppression and may relate to ultraviolet radiation exposure. In contrast, the greatly increased risks for Merkel cell and sebaceous carcinoma suggest an etiologic role for immunosuppression. JF - AIDS AU - Lanoy, E AU - Dores, G M AU - Madeleine, M M AU - Toro, J R AU - Fraumeni, JF Jr AU - Engels, E A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 7076, Rockville, MD 20892, USA, engelse@exchange.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 385 EP - 393 VL - 23 IS - 3 SN - 0269-9370, 0269-9370 KW - Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - demography KW - Acquired immune deficiency syndrome KW - homosexuality KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - Skin cancer KW - Melanoma KW - Demography KW - CD4 antigen KW - U.V. radiation KW - Risk factors KW - Ultraviolet radiation KW - Ethnic groups KW - Skin KW - Data processing KW - melanoma KW - Cancer KW - Carcinoma KW - USA KW - Epidemiology KW - Standards KW - Immunosuppression KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20368472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Epidemiology+of+nonkeratinocytic+skin+cancers+among+persons+with+AIDS+in+the+United+States&rft.au=Lanoy%2C+E%3BDores%2C+G+M%3BMadeleine%2C+M+M%3BToro%2C+J+R%3BFraumeni%2C+JF+Jr%3BEngels%2C+E+A&rft.aulast=Lanoy&rft.aufirst=E&rft.date=2009-01-01&rft.volume=23&rft.issue=3&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e3283213046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Demography; CD4 antigen; Acquired immune deficiency syndrome; Data processing; U.V. radiation; Epidemiology; Risk factors; Skin cancer; Ethnic groups; Immunosuppression; Melanoma; Carcinoma; demography; Skin; Ultraviolet radiation; homosexuality; Standards; melanoma; Cancer; USA; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir DO - http://dx.doi.org/10.1097/QAD.0b013e3283213046 ER - TY - JOUR T1 - Research paper: Induction of lactoferrin gene expression by innate immune stimuli in mouse mammary epithelial HC-11 cells AN - 20346492; 9011899 AB - Lactoferrin (LF) is a multifunctional protein. While its functions and mechanism of actions are actively being investigated, the cellular signals that regulate LF expression have not been as explored. We have previously demonstrated that LF is upregulated by estrogen in the reproductive system. In this study, we show that the expression of LF was stimulated by bacterial lipopolysaccharide (LPS) and double-stranded RNA (dsRNA) in normal mouse mammalian HC-11 cells. When cells were exposed to either LPS or dsRNA, the mRNA and protein of LF were increased in a dose - and time-dependent manner, yet the kinetics of LF induction by dsRNA or LPS were different. The LPS and dsRNA-induced LF was mainly released into the culture medium where it blocked TNF-a production in exposed cells. We explored the mechanisms of LF induction by LPS and dsRNA using specific inhibitors and found that the induction could be attenuated by inhibitors to PKC, NF-kB, p38 and JNK, but not by an inhibitor to PKA. Interestingly, ERK inhibitor was effective against dsRNA but not against LPS induction of LF. These data suggest that LF was induced by LPS and dsRNA through PKC, NF-kB and MAPK pathways which in turn play an inhibitory role in the continuation of innate inflammation. JF - Biochimie AU - Li, Yin AU - Limmon, Gino V AU - Imani, Farhad AU - Teng, Christina AD - Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA, teng1@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 58 EP - 67 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 91 IS - 1 SN - 0300-9084, 0300-9084 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Lactoferrin KW - LPS KW - dsRNA KW - HC-11 cells KW - PKC KW - MAPK KW - NF-kB KW - Inhibitors KW - Protein kinase C KW - Protein kinase A KW - MAP kinase KW - Estrogens KW - c-Jun amino-terminal kinase KW - Data processing KW - Double-stranded RNA KW - Cell culture KW - Tumor necrosis factor-a KW - Reproductive system KW - Inflammation KW - Gene expression KW - Extracellular signal-regulated kinase KW - Kinetics KW - lactoferrin KW - NF-B protein KW - Lipopolysaccharides KW - J 02310:Genetics & Taxonomy KW - W 30940:Products KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimie&rft.atitle=Research+paper%3A+Induction+of+lactoferrin+gene+expression+by+innate+immune+stimuli+in+mouse+mammary+epithelial+HC-11+cells&rft.au=Li%2C+Yin%3BLimmon%2C+Gino+V%3BImani%2C+Farhad%3BTeng%2C+Christina&rft.aulast=Li&rft.aufirst=Yin&rft.date=2009-01-01&rft.volume=91&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Biochimie&rft.issn=03009084&rft_id=info:doi/10.1016%2Fj.biochi.2008.04.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Estrogens; MAP kinase; Protein kinase A; Data processing; c-Jun amino-terminal kinase; Double-stranded RNA; Cell culture; Tumor necrosis factor-a; Reproductive system; Inflammation; Gene expression; Extracellular signal-regulated kinase; Kinetics; NF-B protein; lactoferrin; Lipopolysaccharides DO - http://dx.doi.org/10.1016/j.biochi.2008.04.014 ER - TY - JOUR T1 - A novel signaling pathway impact analysis AN - 20302503; 8921174 AB - Motivation: Gene expression class comparison studies may identify hundreds or thousands of genes as differentially expressed (DE) between sample groups. Gaining biological insight from the result of such experiments can be approached, for instance, by identifying the signaling pathways impacted by the observed changes. Most of the existing pathway analysis methods focus on either the number of DE genes observed in a given pathway (enrichment analysis methods), or on the correlation between the pathway genes and the class of the samples (functional class scoring methods). Both approaches treat the pathways as simple sets of genes, disregarding the complex gene interactions that these pathways are built to describe.Results: We describe a novel signaling pathway impact analysis (SPIA) that combines the evidence obtained from the classical enrichment analysis with a novel type of evidence, which measures the actual perturbation on a given pathway under a given condition. A bootstrap procedure is used to assess the significance of the observed total pathway perturbation. Using simulations we show that the evidence derived from perturbations is independent of the pathway enrichment evidence. This allows us to calculate a global pathway significance P-value, which combines the enrichment and perturbation P-values. We illustrate the capabilities of the novel method on four real datasets. The results obtained on these data show that SPIA has better specificity and more sensitivity than several widely used pathway analysis methods.Availability: SPIA was implemented as an R package available at http://vortex.cs.wayne.edu/ontoexpress/: Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Tarca, Adi Laurentiu AU - Draghici, Sorin AU - Khatri, Purvesh AU - Hassan, Sonia S AU - Mittal, Pooja AU - Kim, Jung-sun AU - Kim, Chong Jai AU - Kusanovic, Juan Pedro AU - Romero, Roberto AD - 1 Department of Computer Science, Wayne State University, 431 State Hall, Detroit, MI 48202 and 2 Perinatology Research Branch-NIH-NICHD, 4 Brush, 3990 John R, Detroit, MI 48201, USA, sorin@wayne.edu Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 75 EP - 82 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 1 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - Bioinformatics KW - Signal transduction KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=A+novel+signaling+pathway+impact+analysis&rft.au=Tarca%2C+Adi+Laurentiu%3BDraghici%2C+Sorin%3BKhatri%2C+Purvesh%3BHassan%2C+Sonia+S%3BMittal%2C+Pooja%3BKim%2C+Jung-sun%3BKim%2C+Chong+Jai%3BKusanovic%2C+Juan+Pedro%3BRomero%2C+Roberto&rft.aulast=Tarca&rft.aufirst=Adi&rft.date=2009-01-01&rft.volume=25&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn577 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Bioinformatics; Signal transduction DO - http://dx.doi.org/10.1093/bioinformatics/btn577 ER - TY - JOUR T1 - Evidence for Translocation of Microbial Products in Patients with Idiopathic CD4 Lymphocytopenia AN - 20187983; 10190598 AB - Translocation of microbial products has been described in chronic human immunodeficiency virus (HIV) infection and correlates with activation of the immune system. We investigated the potential translocation of microbial products in idiopathic CD4 lymphocytopenia (ICL), a rare disorder characterized by low CD4 T cell counts in the absence of HIV infection. Plasma lipopolysaccharide (LPS) levels and T cell activation were measured in a cross-sectional cohort study of patients with ICL and HIV infection and healthy control subjects. Increases in CD4 T cell proliferation but not CD8 T cell proliferation were observed in patients with ICL. LPS levels were significantly elevated both in patients with ICL and in patients with HIV infection, and they were strongly correlated with the proportion of proliferating CD4 T cells in the cohort of patients with ICL ([image] ; [image]). The proportions of T helper (Th) 17 and Th1 CD4 cells in peripheral blood were similar between patients with ICL, patients with HIV infection, and control subjects. These findings suggest a potential association of translocation of microbial products with perturbed CD4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection. JF - Journal of Infectious Diseases AU - Lee, Philip I AU - Ciccone, Emily J AU - Read, Sarah W AU - Asher, Ava AU - Pitts, Robert AU - Douek, Daniel C AU - Brenchley, Jason M AU - Sereti, Irini AD - Laboratory of Immunoregulation, Clinical and Molecular Retrovirology Section, Division of AIDS, Human Immunology Section, Vaccine Research Center, and Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, isereti@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1664 EP - 1670 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 11 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Helper cells KW - Immune system KW - Lymphopenia KW - Peripheral blood KW - Homeostasis KW - CD8 antigen KW - Cell activation KW - CD4 antigen KW - Human immunodeficiency virus KW - Chronic infection KW - Lymphocytes T KW - Lipopolysaccharides KW - Cell proliferation KW - Translocation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20187983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Evidence+for+Translocation+of+Microbial+Products+in+Patients+with+Idiopathic+CD4+Lymphocytopenia&rft.au=Lee%2C+Philip+I%3BCiccone%2C+Emily+J%3BRead%2C+Sarah+W%3BAsher%2C+Ava%3BPitts%2C+Robert%3BDouek%2C+Daniel+C%3BBrenchley%2C+Jason+M%3BSereti%2C+Irini&rft.aulast=Lee&rft.aufirst=Philip&rft.date=2009-01-01&rft.volume=199&rft.issue=11&rft.spage=1664&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F598953 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Immune system; Helper cells; Lymphopenia; Peripheral blood; CD8 antigen; Homeostasis; Cell activation; CD4 antigen; Chronic infection; Lymphocytes T; Lipopolysaccharides; Cell proliferation; Translocation; Human immunodeficiency virus DO - http://dx.doi.org/10.1086/598953 ER - TY - JOUR T1 - Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1 AN - 20083906; 10095116 JF - Advances in Enzyme Regulation AU - Shears, Stephen B AD - Inositol Signaling Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, USA, shears@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 87 EP - 96 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 49 IS - 1 SN - 0065-2571, 0065-2571 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - inositol phosphate KW - Enzymes KW - Signal transduction KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20083906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Sex+Differences+in+WISC-III+Profiles+of+Children+with+High-functioning+Pervasive+Developmental+Disorders&rft.au=Koyama%2C+Tomonori%3BKamio%2C+Yoko%3BInada%2C+Naoko%3BKurita%2C+Hiroshi&rft.aulast=Koyama&rft.aufirst=Tomonori&rft.date=2009-01-01&rft.volume=39&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0610-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Integration; inositol phosphate; Enzymes; Signal transduction DO - http://dx.doi.org/10.1016/j.advenzreg.2008.12.008 ER - TY - JOUR T1 - Acute but not Chronic Donepezil Increases Muscarinic Receptor-Mediated Signaling via Arachidonic Acid in Unanesthetized Rats AN - 20073920; 10081595 AB - Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Muscarinic receptors are coupled to cytosolic phospholipase A_{2} (cPLA_{2}) activation and arachidonic acid (AA) release from synaptic membrane phospholipid. This activation can be imaged in rodents as an AA incorporation coefficient k*, using quantitative autoradiography. Acute and chronic effects of donepezil on the AA signal, k* for AA, were measured in 81 brain regions of unanesthetized rats. Twenty min after a single oral dose (3.0 mg/kg) of donepezil, k* was increased significantly in 37 brain regions, whereas k* did not differ from control 7 h afterwards or following chronic (21 days) of donepezil. Pretreatment with atropine prevented the 20-min increments in k* following donepezil. Donepezil also increased the brain ACh concentration and reduced brain AChE activity, but did not change cPLA_{2} activity, regardless of administration regimen. These results show that donepezil acutely increases the brain AA signal that is mediated by ACh acting at muscarinic receptors, but that this signal is rapidly desensitized despite continued elevated brain ACh concentration. In contrast, the AA signal in response to arecoline was not altered following donepezil. JF - Journal of Alzheimer's Disease AU - Basselin, Mireille AU - Nguyen, Henry N AU - Chang, Lisa AU - Bell, Jane M AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 369 EP - 382 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG The Netherlands VL - 17 IS - 2 SN - 1387-2877, 1387-2877 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Phospholipase A2 KW - Acetylcholinesterase KW - Alzheimer's disease KW - Acetylcholine receptors (muscarinic) KW - Brain KW - Arachidonic acid KW - donepezil KW - Acetylcholine receptors KW - Autoradiography KW - Neurodegenerative diseases KW - Synaptic membranes KW - Chronic effects KW - Acetylcholine KW - Phospholipids KW - Signal transduction KW - Atropine KW - X 24310:Pharmaceuticals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20073920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+Disease&rft.atitle=Acute+but+not+Chronic+Donepezil+Increases+Muscarinic+Receptor-Mediated+Signaling+via+Arachidonic+Acid+in+Unanesthetized+Rats&rft.au=Basselin%2C+Mireille%3BNguyen%2C+Henry+N%3BChang%2C+Lisa%3BBell%2C+Jane+M%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2009-01-01&rft.volume=17&rft.issue=2&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+Alzheimer%27s+Disease&rft.issn=13872877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Acetylcholinesterase; Phospholipase A2; Acetylcholine receptors (muscarinic); Alzheimer's disease; Brain; Arachidonic acid; donepezil; Autoradiography; Acetylcholine receptors; Neurodegenerative diseases; Synaptic membranes; Chronic effects; Acetylcholine; Atropine; Signal transduction; Phospholipids ER - TY - JOUR T1 - Clinical and Dosimetric Predictors of Acute Toxicity After a 4-Week Hypofractionated External Beam Radiotherapy Regimen for Prostate Cancer: Results From a Multicentric Prospective Trial AN - 19700886; 9068317 AB - To investigate predictors for gastrointestinal (GI) and genitourinary (GU) acute toxicity after a short-course hypofractionated radiotherapy regimen for prostate cancer. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Arcangeli, Stefano AU - Strigari, Lidia AU - Soete, Guy AU - De Meerleer, Gert AU - Gomellini, Sara AU - Fonteyne, Valerie AU - Storme, Guy AU - Arcangeli, Giorgio AD - Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy, stefano.arcangeli@yahoo.it Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 39 EP - 45 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 73 IS - 1 SN - 0360-3016, 0360-3016 KW - Toxicology Abstracts KW - Prostate cancer KW - Radiotherapy KW - Hypofractionation KW - Acute toxicity KW - BED KW - Clinical trials KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19700886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Clinical+and+Dosimetric+Predictors+of+Acute+Toxicity+After+a+4-Week+Hypofractionated+External+Beam+Radiotherapy+Regimen+for+Prostate+Cancer%3A+Results+From+a+Multicentric+Prospective+Trial&rft.au=Arcangeli%2C+Stefano%3BStrigari%2C+Lidia%3BSoete%2C+Guy%3BDe+Meerleer%2C+Gert%3BGomellini%2C+Sara%3BFonteyne%2C+Valerie%3BStorme%2C+Guy%3BArcangeli%2C+Giorgio&rft.aulast=Arcangeli&rft.aufirst=Stefano&rft.date=2009-01-01&rft.volume=73&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2008.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Prostate cancer; Radiotherapy; Acute toxicity; Clinical trials DO - http://dx.doi.org/10.1016/j.ijrobp.2008.04.005 ER - TY - JOUR T1 - Origins of Stochasticity and Burstiness in High-Dimensional Biochemical Networks AN - 19515792; 8830178 AB - Two major approaches are known in the field of stochastic dynamics of intracellular biochemical networks. The first one places the focus of attention on the fact that many biochemical constituents vitally important for the network functionality may be present only in small quantities within the cell, and therefore the regulatory process is essentially discrete and prone to relatively big fluctuations. The second approach treats the regulatory process as essentially continuous. Complex pseudostochastic behavior in such processes may occur due to multistability and oscillatory motions within limit cycles. In this paper we outline the third scenario of stochasticity in the regulatory process. This scenario is only conceivable in high-dimensional highly nonlinear systems. In particular, we show that burstiness, a well-known phenomenon in the biology of gene expression, is a natural consequence of high dimensionality coupled with high nonlinearity. In mathematical terms, burstiness is associated with heavy-tailed probability distributions of stochastic processes describing the dynamics of the system. We demonstrate how the 'shot' noise originates from purely deterministic behavior of the underlying dynamical system. We conclude that the limiting stochastic process may be accurately approximated by the 'heavy-tailed' generalized Pareto process which is a direct mathematical expression of burstiness. JF - Eurasip Journal on Bioinformatics and Systems Biology AU - Rosenfeld, Simon AD - Division of Cancer Prevention (DCP) National Cancer Institute EPN 3108 6130 Executive Blvd Bethesda MO 20892, rosenfes@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 PB - Hindawi Publishing Corporation, P.O. Box 3079 VL - 2009 SN - 1687-4145, 1687-4145 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - Bioinformatics KW - nonlinear systems KW - Stochasticity KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.atitle=Origins+of+Stochasticity+and+Burstiness+in+High-Dimensional+Biochemical+Networks&rft.au=Rosenfeld%2C+Simon&rft.aulast=Rosenfeld&rft.aufirst=Simon&rft.date=2009-01-01&rft.volume=2009&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.issn=16874145&rft_id=info:doi/10.1155%2F2009%2F362309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stochasticity; Computer programs; nonlinear systems; Gene expression; Bioinformatics DO - http://dx.doi.org/10.1155/2009/362309 ER - TY - JOUR T1 - Evaluation of random forests performance for genome-wide association studies in the presence of interaction effects AN - 1034820738; 16899279 AB - Random forests (RF) is one of a broad class of machine learning methods that are able to deal with large-scale data without model specification, which makes it an attractive method for genome-wide association studies (GWAS). The performance of RF and other association methods in the presence of interactions was evaluated using the simulated data from Genetic Analysis Workshop 16 Problem 3, with knowledge of the major causative markers, risk factors, and their interactions in the simulated traits. There was good power to detect the environmental risk factors using RF, trend tests, or regression analyses but the power to detect the effects of the causal markers was poor for all methods. The causal marker that had an interactive effect with smoking did show moderate evidence of association in the RF and regression analyses, suggesting that RF may perform well at detecting such interactions in larger, more highly powered datasets. JF - BMC Proceedings AU - Kim, Yoonhee AU - Wojciechowski, Robert AU - Sung, Heejong AU - Mathias, Rasika A AU - Wang, Li AU - Klein, Alison P AU - Lenroot, Rhoshel K AU - Malley, James AU - Bailey-Wilson, Joan E AD - National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 3 IS - Suppl 7 SN - 1753-6561, 1753-6561 KW - Risk Abstracts KW - Forests KW - Risk factors KW - Smoking KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034820738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Proceedings&rft.atitle=Evaluation+of+random+forests+performance+for+genome-wide+association+studies+in+the+presence+of+interaction+effects&rft.au=Kim%2C+Yoonhee%3BWojciechowski%2C+Robert%3BSung%2C+Heejong%3BMathias%2C+Rasika+A%3BWang%2C+Li%3BKlein%2C+Alison+P%3BLenroot%2C+Rhoshel+K%3BMalley%2C+James%3BBailey-Wilson%2C+Joan+E&rft.aulast=Kim&rft.aufirst=Yoonhee&rft.date=2009-01-01&rft.volume=3&rft.issue=Suppl+7&rft.spage=S64&rft.isbn=&rft.btitle=&rft.title=BMC+Proceedings&rft.issn=17536561&rft_id=info:doi/ L2 - http://www.biomedcentral.com/1753-6561/3/S7/S64 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 11 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Smoking; Risk factors; Forests ER - TY - JOUR T1 - Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. AN - 69932278; 19104039 AB - A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive nuclear factor-kappaB (NF-kappaB) signaling for survival. Small molecule inhibitors of IkappaB kinase beta (IKKbeta), a key regulator of the NF-kappaB pathway, kill ABC DLBCL cells and hold promise for the treatment of this lymphoma type. We conducted an RNA interference genetic screen to investigate potential mechanisms of resistance of ABC DLBCL cells to IKKbeta inhibitors. We screened a library of small hairpin RNAs (shRNAs) targeting 500 protein kinases for shRNAs that would increase the killing of an ABC DLBCL cell line in the presence of a small molecule IKKbeta inhibitor. Two independent shRNAs targeting IKKalpha synergized with the IKKbeta inhibitor to kill three different ABC DLBCL cell lines but were not toxic by themselves. Surprisingly, IKKalpha shRNAs blocked the classical rather than the alternative NF-kappaB pathway in ABC DLBCL cells, as judged by inhibition of IkappaBalpha phosphorylation. IKKalpha shRNA toxicity was reversed by coexpression of wild-type but not kinase inactive forms of IKKalpha, suggesting that IKKalpha may directly phosphorylate IkappaBalpha under conditions of IKKbeta inhibition. In models of physiologic NF-kappaB pathway activation by CARD11 or tumor necrosis factor-alpha, compensatory IKKalpha activity was also observed with IKKbeta inhibition. These results suggest that therapy for ABC DLBCL may be improved by targeting both IKKalpha and IKKbeta, possibly through CARD11 inhibition. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Lam, Lloyd T AU - Davis, R Eric AU - Ngo, Vu N AU - Lenz, Georg AU - Wright, George AU - Xu, Weihong AU - Zhao, Hong AU - Yu, Xin AU - Dang, Lenny AU - Staudt, Louis M AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12/30/ PY - 2008 DA - 2008 Dec 30 SP - 20798 EP - 20803 VL - 105 IS - 52 KW - CARD Signaling Adaptor Proteins KW - 0 KW - NF-kappa B KW - Protein Kinase Inhibitors KW - Tumor Necrosis Factor-alpha KW - I-kappa B Kinase KW - EC 2.7.11.10 KW - CARD11 protein, human KW - EC 4.6.1.2 KW - Guanylate Cyclase KW - Index Medicus KW - Guanylate Cyclase -- metabolism KW - Humans KW - CARD Signaling Adaptor Proteins -- metabolism KW - Jurkat Cells KW - Drug Delivery Systems -- methods KW - Tumor Necrosis Factor-alpha -- metabolism KW - RNA Interference KW - Drug Screening Assays, Antitumor -- methods KW - Phosphorylation -- drug effects KW - I-kappa B Kinase -- metabolism KW - I-kappa B Kinase -- antagonists & inhibitors KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- pharmacology KW - Signal Transduction -- drug effects KW - Lymphoma, Large B-Cell, Diffuse -- enzymology KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69932278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Compensatory+IKKalpha+activation+of+classical+NF-kappaB+signaling+during+IKKbeta+inhibition+identified+by+an+RNA+interference+sensitization+screen.&rft.au=Lam%2C+Lloyd+T%3BDavis%2C+R+Eric%3BNgo%2C+Vu+N%3BLenz%2C+Georg%3BWright%2C+George%3BXu%2C+Weihong%3BZhao%2C+Hong%3BYu%2C+Xin%3BDang%2C+Lenny%3BStaudt%2C+Louis+M&rft.aulast=Lam&rft.aufirst=Lloyd&rft.date=2008-12-30&rft.volume=105&rft.issue=52&rft.spage=20798&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0806491106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2000 Jul 15;165(2):804-12 [10878354] Blood. 2008 Apr 1;111(7):3701-13 [18160665] J Biol Chem. 2000 Aug 25;275(34):25883-91 [10823818] Science. 2000 Sep 1;289(5484):1550-4 [10968790] Mol Cell. 2001 Feb;7(2):401-9 [11239468] Science. 2001 Mar 16;291(5511):2162-5 [11251123] Nature. 2001 Jul 19;412(6844):346-51 [11460167] Science. 2001 Aug 24;293(5534):1495-9 [11520989] Genome Biol. 2001;2(10):RESEARCH0041 [11597333] Cell. 2001 Dec 14;107(6):763-75 [11747812] J Exp Med. 2001 Dec 17;194(12):1861-74 [11748286] Nat Immunol. 2002 Sep;3(9):830-5 [12154356] J Exp Med. 2002 Sep 16;196(6):743-52 [12235208] Nat Immunol. 2002 Oct;3(10):958-65 [12352969] EMBO J. 2002 Oct 15;21(20):5375-85 [12374738] J Immunol. 2003 May 1;170(9):4630-7 [12707341] Nature. 2003 Jun 5;423(6940):659-63 [12789343] Nat Rev Drug Discov. 2004 Jan;3(1):17-26 [14708018] Mol Cell. 2004 May 7;14(3):289-301 [15125833] Mol Cell. 2004 Aug 27;15(4):535-48 [15327770] Immunity. 2004 Oct;21(4):477-89 [15485626] Cell. 1997 Oct 17;91(2):243-52 [9346241] Science. 1998 Aug 28;281(5381):1360-3 [9721103] Science. 1999 Apr 9;284(5412):309-13 [10195894] Science. 1999 Apr 9;284(5412):321-5 [10195897] Clin Cancer Res. 2005 Jan 1;11(1):28-40 [15671525] Adv Immunol. 2005;87:163-208 [16102574] J Exp Med. 2005 Nov 21;202(10):1423-31 [16301747] Immunity. 2005 Dec;23(6):561-74 [16356855] Immunity. 2005 Dec;23(6):575-85 [16356856] Nature. 2006 May 4;441(7089):106-10 [16572121] J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001 [16525037] Blood. 2006 Jun 1;107(11):4266-73 [16439676] Mol Cell. 2006 Jul 7;23(1):13-23 [16818229] Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):908-13 [17213322] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6359-64 [17404218] Cancer Cell. 2007 Aug;12(2):115-30 [17692804] Cell. 2007 Sep 7;130(5):918-31 [17803913] Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3503-8 [18292232] Science. 2008 Mar 21;319(5870):1676-9 [18323416] Genes Dev. 2000 Jul 15;14(14):1729-33 [10898787] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0806491106 ER - TY - JOUR T1 - Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families. AN - 66650840; 19111067 AB - Disulphide bridges are well known to play key roles in stability, folding and functions of proteins. Introduction or deletion of disulphides by site-directed mutagenesis have produced varying effects on stability and folding depending upon the protein and location of disulphide in the 3-D structure. Given the lack of complete understanding it is worthwhile to learn from an analysis of extent of conservation of disulphides in homologous proteins. We have also addressed the question of what structural interactions replaces a disulphide in a homologue in another homologue. Using a dataset involving 34,752 pairwise comparisons of homologous protein domains corresponding to 300 protein domain families of known 3-D structures, we provide a comprehensive analysis of extent of conservation of disulphide bridges and their structural features. We report that only 54% of all the disulphide bonds compared between the homologous pairs are conserved, even if, a small fraction of the non-conserved disulphides do include cytoplasmic proteins. Also, only about one fourth of the distinct disulphides are conserved in all the members in protein families. We note that while conservation of disulphide is common in many families, disulphide bond mutations are quite prevalent. Interestingly, we note that there is no clear relationship between sequence identity between two homologous proteins and disulphide bond conservation. Our analysis on structural features at the sites where cysteines forming disulphide in one homologue are replaced by non-Cys residues show that the elimination of a disulphide in a homologue need not always result in stabilizing interactions between equivalent residues. We observe that in the homologous proteins, disulphide bonds are conserved only to a modest extent. Very interestingly, we note that extent of conservation of disulphide in homologous proteins is unrelated to the overall sequence identity between homologues. The non-conserved disulphides are often associated with variable structural features that were recruited to be associated with differentiation or specialisation of protein function. JF - BMC structural biology AU - Thangudu, Ratna R AU - Manoharan, Malini AU - Srinivasan, N AU - Cadet, Frédéric AU - Sowdhamini, R AU - Offmann, Bernard AD - Laboratoire de Biochimie et Génétique Moléculaire, Université de La Réunion, BP 7151, 15 avenue René Cassin, 97715 Saint Denis Messag Cedex 09, La Réunion, France. thangudr@ncbi.nlm.nih.gov Y1 - 2008/12/26/ PY - 2008 DA - 2008 Dec 26 SP - 55 VL - 8 KW - Disulfides KW - 0 KW - Proteins KW - Solvents KW - Cystine KW - 48TCX9A1VT KW - Index Medicus KW - Cystine -- chemistry KW - Solvents -- chemistry KW - Sequence Alignment KW - Conserved Sequence KW - Databases, Protein KW - Protein Structure, Tertiary KW - Protein Conformation KW - Structural Homology, Protein KW - Disulfides -- chemistry KW - Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66650840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+structural+biology&rft.atitle=Analysis+on+conservation+of+disulphide+bonds+and+their+structural+features+in+homologous+protein+domain+families.&rft.au=Thangudu%2C+Ratna+R%3BManoharan%2C+Malini%3BSrinivasan%2C+N%3BCadet%2C+Fr%C3%A9d%C3%A9ric%3BSowdhamini%2C+R%3BOffmann%2C+Bernard&rft.aulast=Thangudu&rft.aufirst=Ratna&rft.date=2008-12-26&rft.volume=8&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=BMC+structural+biology&rft.issn=1472-6807&rft_id=info:doi/10.1186%2F1472-6807-8-55 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-16 N1 - Date created - 2009-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Eng. 2002 Dec;15(12):951-3 [12601133] Protein Eng. 2003 Mar;16(3):187-93 [12702798] Proteins. 2003 Oct 1;53(1):1-5 [12945044] Annu Rev Biochem. 2003;72:111-35 [12524212] J Mol Biol. 2004 Jan 23;335(4):1083-92 [14698301] Biol Chem. 2003 Dec;384(12):1553-63 [14719797] J Biol Chem. 2004 Mar 5;279(10):9298-305 [14613939] Bioinformatics. 2004 Mar 22;20(5):653-9 [15033872] Biochem Biophys Res Commun. 2004 May 21;318(1):142-7 [15110765] Proteins. 2004 Jun 1;55(4):1036-42 [15146500] Trends Biochem Sci. 1989 Jul;14(7):304-9 [2672455] Protein Eng. 1989 Nov;3(2):95-103 [2594728] Protein Eng. 1990 Jul;3(7):591-8 [1699222] Protein Eng. 1990 Aug;3(8):667-72 [2217140] Proteomics. 2004 Jun;4(6):1665-71 [15174135] Protein Eng Des Sel. 2004 Apr;17(4):367-73 [15166311] J Mol Biol. 1971 Feb 14;55(3):379-400 [5551392] Nature. 1976 Jun 17;261(5561):552-8 [934293] Adv Protein Chem. 1981;34:167-339 [7020376] Adv Protein Chem. 1981;34:61-92 [6266231] J Mol Biol. 1981 Sep 15;151(2):261-87 [7338898] J Biochem. 1983 Sep;94(3):997-1007 [6643433] Biopolymers. 1983 Dec;22(12):2577-637 [6667333] Biochemistry. 1985 Mar 12;24(6):1501-9 [3986190] Bioessays. 1988 Feb-Mar;8(2):57-63 [3282505] Science. 1989 Feb 10;243(4892):792-4 [2916125] Protein Eng. 1988 Sep;2(3):193-9 [3237684] Protein Eng. 1988 Jul;2(2):119-25 [3244694] J Mol Biol. 1999 Dec 10;294(4):1027-40 [10588904] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] EMBO J. 2000 Jan 17;19(2):164-73 [10637221] J Mol Biol. 2000 Jan 28;295(4):903-14 [10656799] J Mol Biol. 2000 Mar 17;297(1):233-49 [10704319] Biochemistry. 2000 Apr 18;39(15):4207-16 [10757967] Chem Pharm Bull (Tokyo). 2000 Apr;48(4):480-5 [10783065] Bioinformatics. 2000 Mar;16(3):251-6 [10869018] J Mol Biol. 2000 Jul 21;300(4):975-85 [10891282] J Mol Biol. 2000 Jul 21;300(4):1005-16 [10891285] J Mol Biol. 2000 Aug 11;301(2):433-50 [10926519] J Biomol NMR. 2000 Oct;18(2):165-71 [11101221] Protein Sci. 2000 Oct;9(10):1889-97 [11106161] Structure. 2000 Dec 15;8(12):1267-78 [11188691] Protein Sci. 2000 Dec;9(12):2394-404 [11206061] J Mol Biol. 2001 Mar 23;307(2):671-81 [11254389] Cell. 2001 Apr 6;105(1):103-13 [11301006] Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20 [11331761] J Mol Biol. 2001 Jul 13;310(3):617-34 [11439028] Biochemistry. 2001 Aug 7;40(31):9059-64 [11478871] Bioinformatics. 2001 Aug;17(8):721-8 [11524373] Nat Struct Biol. 2001 Sep;8(9):770-4 [11524679] Structure. 2001 Apr 4;9(4):331-40 [11525170] Bioinformatics. 2001 Oct;17(10):957-64 [11673241] Proteins. 2002 Feb 15;46(3):243-9 [11835499] Protein Eng. 2002 Jan;15(1):59-64 [11842239] Methods Enzymol. 2002;353:10-21 [12078485] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9679-84 [12107280] Protein Sci. 2002 Nov;11(11):2735-9 [12381855] Bioinformatics. 2003 Jan 22;19(2):313-4 [12538266] J Bacteriol. 1991 Dec;173(23):7719-22 [1938970] Methods Enzymol. 1991;202:336-56 [1784181] FEBS Lett. 1992 May 11;302(2):117-20 [1633841] Proteins. 1992 Oct;14(2):309-23 [1409577] Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):597-604 [8224474] Protein Sci. 1993 Oct;2(10):1551-8 [8251931] Protein Sci. 1994 Jan;3(1):92-102 [8142902] J Mol Biol. 1994 Apr 22;238(1):54-61 [8145256] Biochem Mol Biol Int. 1994 Aug;33(6):1049-53 [7804129] J Mol Biol. 1995 Apr 7;247(4):536-40 [7723011] Protein Sci. 1995 Nov;4(11):2405-10 [8563638] J Mol Biol. 1996 Jun 14;259(3):480-501 [8676383] Biochemistry. 1996 Aug 13;35(32):10328-38 [8756688] J Mol Biol. 1996 Dec 6;264(3):603-23 [8969308] Proteins. 1997 Mar;27(3):360-6 [9094738] J Biol Chem. 1997 Jun 20;272(25):15661-7 [9188456] J Mol Biol. 1997 Oct 3;272(4):597-612 [9325115] Biochemistry. 1998 Feb 3;37(5):1292-301 [9477955] Biochemistry. 1998 Sep 29;37(39):13475-85 [9753433] Structure. 1998 Sep 15;6(9):1195-206 [9753698] J Mol Biol. 1998 Oct 30;283(3):657-68 [9784374] J Mol Biol. 1998 Dec 4;284(3):541-8 [9826496] Cell. 1999 Feb 5;96(3):341-52 [10025400] Trends Biochem Sci. 1999 Jan;24(1):34-6 [10087920] Biochem Biophys Res Commun. 1999 Apr 13;257(2):418-24 [10198229] Proteins. 1999 Aug 15;36(3):340-6 [10409827] Proteins. 2005 Mar 1;58(4):866-79 [15645448] J Mol Biol. 2005 Apr 1;347(3):565-81 [15755451] J Biol Chem. 2005 Mar 25;280(12):11387-94 [15642731] Bioinformatics. 2005 Apr 15;21(8):1415-20 [15585533] Bioinformatics. 2005 May 15;21(10):2336-46 [15741247] Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W230-2 [15980459] Proteins. 2005 Nov 15;61(3):535-44 [16184609] Bioinformatics. 2005 Dec 15;21(24):4416-9 [16223789] Proteins. 2007 May 1;67(2):255-61 [17285632] Extremophiles. 2008 Jan;12(1):29-38 [17508126] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1472-6807-8-55 ER - TY - JOUR T1 - Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). AN - 69921605; 19053756 AB - Here, we examine the significance that stereochemistry plays within the clinically relevant Janus kinase 3 (Jak3) inhibitor 1 (CP-690,550). A synthesis of all four enantiopure stereoisomers of the drug was carried out and an examination of each compound revealed that only the enantiopure 3R,4R isomer was capable of blocking Stat5 phosphorylation (Jak3 dependent). Each compound was profiled across a panel of over 350 kinases, which revealed a high level of selectivity for the Jak family kinases for these related compounds. Each stereoisomer retained a degree of binding to Jak3 and Jak2 and the 3R,4S and 3S,4R stereoisomers were further revealed to have binding affinity for selected members of the STE7 and STE20 subfamily of kinases. Finally, an appraisal of the minimum energy conformation of each stereoisomer and molecular docking at Jak3 was performed in an effort to better understand each compounds selectivity and potency profiles. JF - Journal of medicinal chemistry AU - Jiang, Jian-kang AU - Ghoreschi, Kamran AU - Deflorian, Francesca AU - Chen, Zhi AU - Perreira, Melissa AU - Pesu, Marko AU - Smith, Jeremy AU - Nguyen, Dac-Trung AU - Liu, Eric H AU - Leister, William AU - Costanzi, Stefano AU - O'Shea, John J AU - Thomas, Craig J AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA. Y1 - 2008/12/25/ PY - 2008 DA - 2008 Dec 25 SP - 8012 EP - 8018 VL - 51 IS - 24 KW - Piperidines KW - 0 KW - Protein Kinase Inhibitors KW - Pyrimidines KW - Pyrroles KW - tofacitinib KW - 87LA6FU830 KW - JAK2 protein, human KW - EC 2.7.10.2 KW - Janus Kinase 2 KW - Index Medicus KW - Stereoisomerism KW - Models, Molecular KW - Kinetics KW - Humans KW - Models, Chemical KW - Molecular Conformation KW - Inhibitory Concentration 50 KW - Monte Carlo Method KW - Janus Kinase 2 -- chemistry KW - Protein Binding KW - Hydrogen Bonding KW - Drug Design KW - Pyrimidines -- chemical synthesis KW - Protein Kinase Inhibitors -- pharmacology KW - Pyrimidines -- pharmacology KW - Protein Kinase Inhibitors -- chemical synthesis KW - Chemistry, Pharmaceutical -- methods KW - Pyrroles -- pharmacology KW - Pyrroles -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69921605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Examining+the+chirality%2C+conformation+and+selective+kinase+inhibition+of+3-%28%283R%2C4R%29-4-methyl-3-%28methyl%287H-pyrrolo%5B2%2C3-d%5Dpyrimidin-4-yl%29amino%29piperidin-1-yl%29-3-oxopropanenitrile+%28CP-690%2C550%29.&rft.au=Jiang%2C+Jian-kang%3BGhoreschi%2C+Kamran%3BDeflorian%2C+Francesca%3BChen%2C+Zhi%3BPerreira%2C+Melissa%3BPesu%2C+Marko%3BSmith%2C+Jeremy%3BNguyen%2C+Dac-Trung%3BLiu%2C+Eric+H%3BLeister%2C+William%3BCostanzi%2C+Stefano%3BO%27Shea%2C+John+J%3BThomas%2C+Craig+J&rft.aulast=Jiang&rft.aufirst=Jian-kang&rft.date=2008-12-25&rft.volume=51&rft.issue=24&rft.spage=8012&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm801142b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Rheumatol. 2005 May;17(3):305-11 [15838241] Blood. 2005 Aug 1;106(3):996-1002 [15831699] Blood. 2006 Jan 1;107(1):176-83 [16174768] Nat Immunol. 2007 Jan;8(1):25-30 [17179969] Nat Biotechnol. 2008 Jan;26(1):127-32 [18183025] Blood. 2008 Feb 15;111(4):2155-7 [18094329] Expert Opin Ther Targets. 2004 Dec;8(6):613-29 [15584866] J Exp Med. 1995 Jan 1;181(1):399-404 [7528775] Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7307-11 [7638186] Science. 1995 Nov 3;270(5237):794-7 [7481767] Science. 1995 Nov 3;270(5237):797-800 [7481768] Cell. 1998 May 1;93(3):397-409 [9590174] Genome Biol. 2004;5(12):253 [15575979] Science. 2003 Oct 31;302(5646):875-8 [14593182] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm801142b ER - TY - JOUR T1 - Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities. AN - 69907921; 19053760 AB - A number of bis(diazeniumdiolates) that we designed to release up to 4 mol of nitric oxide (NO) and that are structural analogues of the NO prodrug and anticancer lead compound O(2)-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino)diazen-1-ium-1,2- diolate (PABA/NO) were synthesized and studied. A majority of these compounds yielded higher levels of NO, were better inhibitors of proliferation of a number of cancer cell lines, and more rapidly induced substantially increased levels of S-glutathionylation of cellular proteins in comparison with PABA/NO. In most cases, the antiproliferative activity and extents of S-glutathionylation correlated well with levels of intracellular NO release. We report bis(diazeniumdiolates) to be a class of S-glutathionylating agents with potent antiproliferative and S-glutathionylating activity. JF - Journal of medicinal chemistry AU - Andrei, Daniela AU - Maciag, Anna E AU - Chakrapani, Harinath AU - Citro, Michael L AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. dandrei@dom.edu Y1 - 2008/12/25/ PY - 2008 DA - 2008 Dec 25 SP - 7944 EP - 7952 VL - 51 IS - 24 KW - Azo Compounds KW - 0 KW - Nitric Oxide Donors KW - Prodrugs KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Prodrugs -- chemistry KW - HL-60 Cells KW - Humans KW - Nitric Oxide -- chemistry KW - Models, Chemical KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Chemistry, Pharmaceutical -- methods KW - Cell Proliferation KW - Drug Design KW - Nitric Oxide Donors -- chemistry KW - Azo Compounds -- chemistry KW - Glutathione -- chemistry KW - Azo Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69907921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Aryl+bis%28diazeniumdiolates%29%3A+potent+inducers+of+S-glutathionylation+of+cellular+proteins+and+their+in+vitro+antiproliferative+activities.&rft.au=Andrei%2C+Daniela%3BMaciag%2C+Anna+E%3BChakrapani%2C+Harinath%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Andrei&rft.aufirst=Daniela&rft.date=2008-12-25&rft.volume=51&rft.issue=24&rft.spage=7944&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm800831y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Adv Enzymol Relat Areas Mol Biol. 1994;69:1-44 [7817866] Blood. 1992 Oct 15;80(8):1880-4 [1382708] Leuk Res. 1995 Aug;19(8):527-33 [7658698] Methods Enzymol. 1996;268:281-93 [8782594] Chem Res Toxicol. 1997 Jan;10(1):2-18 [9074797] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] Leukemia. 1998 Sep;12(9):1461-6 [9737697] Expert Opin Investig Drugs. 2005 Jul;14(7):835-46 [16022573] Curr Top Med Chem. 2005;5(7):597-601 [16101422] Curr Top Med Chem. 2005;5(7):625-36 [16101424] Mol Pharmacol. 2006 Feb;69(2):501-8 [16288082] J Med Chem. 2006 Feb 9;49(3):1157-64 [16451080] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] Leuk Res. 2006 Oct;30(10):1279-83 [16439016] Drug Resist Updat. 2006 Jun;9(3):157-73 [16822706] Biochem Pharmacol. 2007 May 1;73(9):1257-69 [17098212] Cardiovasc Res. 2007 Jul 15;75(2):220-8 [17451659] Blood. 2007 Jul 15;110(2):709-18 [17384201] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Free Radic Biol Med. 2007 Sep 15;43(6):883-98 [17697933] Curr Opin Pharmacol. 2007 Aug;7(4):398-403 [17611156] Curr Opin Pharmacol. 2007 Aug;7(4):381-91 [17662654] Org Lett. 2007 Oct 25;9(22):4551-4 [17918856] Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3 [18178089] Bioorg Med Chem. 2008 Mar 1;16(5):2657-64 [18060792] Antioxid Redox Signal. 2008 Mar;10(3):445-73 [18092936] J Cardiovasc Pharmacol. 1999 Dec;34(6):879-86 [10598133] J Org Chem. 2001 May 4;66(9):3090-8 [11325274] J Biol Chem. 2001 Dec 21;276(51):47763-6 [11684673] Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5103-6 [12697895] J Cell Physiol. 2003 Dec;197(3):426-34 [14566972] Mol Pharmacol. 2004 May;65(5):1070-9 [15102935] Mol Cancer Ther. 2004 Jun;3(6):709-14 [15210857] J Cell Mol Med. 2004 Apr-Jun;8(2):201-12 [15256068] Free Radic Biol Med. 2004 Sep 15;37(6):735-6 [15304248] Biochem Pharmacol. 1988 Jul 1;37(13):2495-501 [3291879] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Chem Res Toxicol. 1991 Mar-Apr;4(2):131-40 [1782341] Blood. 1995 Aug 1;86(3):1184-95 [7542498] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800831y ER - TY - JOUR T1 - Application of binocular vision technology in anterior cruciate ligament surgical navigation system AN - 20478579; 9175818 AB - Based on the failed surgery due to great drilling location errors in rebuilding the knee anterior cruciate ligament, a method was introduced with binocular stereo vision technology rational planning and C-armed X-ray. A new idea that adopts the gridiron pattern marker to simplify the stereo matching process was presented in the self-developed binocular vision positioning system. The calibrated system detected the distance between the pairs of markers which were within 1.5 m distance from the binocular vision sensing units, and the error was less than 1 mm. The application in the anterior cruciate ligament reconstruction surgery shows that the system is stable, reliable, cost-effective, easy-to-calibrate, with sufficient accuracy and high positioning precision, and can meet the requirements of surgical navigation. JF - Journal of Clinical Rehabilitative Tissue Engineering Research AU - Jin-Bing, X AU - Lei, H AU - Peng-Wei, Z AD - Department of Computer, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China, xiejinbing@immc.edu.cn Y1 - 2008/12/23/ PY - 2008 DA - 2008 Dec 23 SP - 10297 EP - 10300 PB - Publishing House of Journal of Clinical Rehabilitative Tissue Engineering Research VL - 12 IS - 52 SN - 1673-8225, 1673-8225 KW - Biotechnology and Bioengineering Abstracts KW - Reconstruction KW - Vision KW - Surgery KW - Ionizing radiation KW - Drilling KW - anterior cruciate ligament KW - Tissue engineering KW - Knee KW - Binocular vision KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20478579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.atitle=Application+of+binocular+vision+technology+in+anterior+cruciate+ligament+surgical+navigation+system&rft.au=Jin-Bing%2C+X%3BLei%2C+H%3BPeng-Wei%2C+Z&rft.aulast=Jin-Bing&rft.aufirst=X&rft.date=2008-12-23&rft.volume=12&rft.issue=52&rft.spage=10297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.issn=16738225&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Reconstruction; Vision; Ionizing radiation; Surgery; Drilling; anterior cruciate ligament; Tissue engineering; Knee; Binocular vision ER - TY - JOUR T1 - Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. AN - 66674524; 19094236 AB - Dependences on addictive substances are substantially-heritable complex disorders whose molecular genetic bases have been partially elucidated by studies that have largely focused on research volunteers, including those recruited in Baltimore. Maryland. Subjects recruited from the Baltimore site of the Epidemiological Catchment Area (ECA) study provide a potentially-useful comparison group for possible confounding features that might arise from selecting research volunteer samples of substance dependent and control individuals. We now report novel SNP (single nucleotide polymorphism) genome wide association (GWA) results for vulnerability to substance dependence in ECA participants, who were initially ascertained as members of a probability sample from Baltimore, and compare the results to those from ethnically-matched Baltimore research volunteers. We identify substantial overlap between the home address zip codes reported by members of these two samples. We find overlapping clusters of SNPs whose allele frequencies differ with nominal significance between substance dependent vs control individuals in both samples. These overlapping clusters of nominally-positive SNPs identify 172 genes in ways that are never found by chance in Monte Carlo simulation studies. Comparison with data from human expressed sequence tags suggests that these genes are expressed in brain, especially in hippocampus and amygdala, to extents that are greater than chance. The convergent results from these probability sample and research volunteer sample datasets support prior genome wide association results. They fail to support the idea that large portions of the molecular genetic results for vulnerability to substance dependence derive from factors that are limited to research volunteers. JF - BMC medical genetics AU - Johnson, Catherine AU - Drgon, Tomas AU - Liu, Qing-Rong AU - Zhang, Ping-Wu AU - Walther, Donna AU - Li, Chuan-Yun AU - Anthony, James C AU - Ding, Yulan AU - Eaton, William W AU - Uhl, George R AD - Molecular Neurobiology Branch, NIH-IRP (NIDA), Suite 3510, 333 Cassell Drive Baltimore, Maryland 21224, USA. johnsoncat@intra.nida.nih.gov Y1 - 2008/12/18/ PY - 2008 DA - 2008 Dec 18 SP - 113 VL - 9 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Alleles KW - Gene Frequency KW - Humans KW - European Continental Ancestry Group KW - Case-Control Studies KW - Baltimore -- epidemiology KW - Male KW - Female KW - Genome, Human KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66674524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+medical+genetics&rft.atitle=Genome+wide+association+for+substance+dependence%3A+convergent+results+from+epidemiologic+and+research+volunteer+samples.&rft.au=Johnson%2C+Catherine%3BDrgon%2C+Tomas%3BLiu%2C+Qing-Rong%3BZhang%2C+Ping-Wu%3BWalther%2C+Donna%3BLi%2C+Chuan-Yun%3BAnthony%2C+James+C%3BDing%2C+Yulan%3BEaton%2C+William+W%3BUhl%2C+George+R&rft.aulast=Johnson&rft.aufirst=Catherine&rft.date=2008-12-18&rft.volume=9&rft.issue=&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=BMC+medical+genetics&rft.issn=1471-2350&rft_id=info:doi/10.1186%2F1471-2350-9-113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-13 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Behav Med. 1989 Apr;12(2):159-82 [2668531] Nucleic Acids Res. 2009 Jan;37(Database issue):D251-60 [18790807] Control Clin Trials. 1990 Apr;11(2):116-28 [2161310] Br J Addict. 1991 Sep;86(9):1119-27 [1932883] Arch Gen Psychiatry. 1992 Sep;49(9):723-7 [1355337] JAMA. 1995 Dec 13;274(22):1786-92 [7500511] Biol Psychiatry. 1996 Oct 15;40(8):776-84 [8894071] Arch Gen Psychiatry. 2000 Mar;57(3):217-22 [10711906] Arch Gen Psychiatry. 2000 Mar;57(3):261-9 [10711912] Am J Med Genet. 2000 Oct 9;96(5):665-70 [11054775] Am J Hum Genet. 2001 Dec;69(6):1290-300 [11704927] JAMA. 2001 Nov 14;286(18):2315-21 [11710898] JAMA. 2001 Nov 14;286(18):2326-8 [11710901] Genet Med. 2003 Jan-Feb;5(1):35-42 [12544474] Nicotine Tob Res. 2004 Jun;6(3):439-46 [15203777] Addict Behav. 1978;3(3-4):235-41 [735910] Am J Epidemiol. 1979 Apr;109(4):394-9 [443238] J Chronic Dis. 1979;32(9-10):633-8 [489703] Arch Gen Psychiatry. 1981 Apr;38(4):381-9 [6260053] J Chronic Dis. 1983;36(10):725-8 [6630408] Arch Gen Psychiatry. 1984 Oct;41(10):934-41 [6089692] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Control Clin Trials. 1998 Dec;19(6):589-601 [9875838] Cancer Epidemiol Biomarkers Prev. 1999 Apr;8(4 Pt 2):369-75 [10207642] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] J Gen Intern Med. 1999 Sep;14(9):537-46 [10491242] Psychol Med. 2004 Oct;34(7):1239-50 [15697050] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9 [16091475] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53 [16894614] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):918-25 [17099884] Hum Mol Genet. 2007 Jan 1;16(1):24-35 [17158188] BMC Genet. 2007;8:10 [17407593] Biochem Pharmacol. 2008 Jan 1;75(1):98-111 [17764662] Arch Gen Psychiatry. 2008 Mar;65(3):345-55 [18316681] Arch Gen Psychiatry. 2008 Jun;65(6):683-93 [18519826] Ann N Y Acad Sci. 2008 Oct;1141:318-81 [18991966] Am J Epidemiol. 1989 Dec;130(6):1088-100 [2589302] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2350-9-113 ER - TY - JOUR T1 - Age-Related Crossover in Breast Cancer Incidence Rates Between Black and White Ethnic Groups AN - 20301201; 8921345 AB - Background Although breast cancer incidence is higher in black women than in white women among women younger than 40 years, the reverse is true among those aged 40 years or older. This crossover in incidence rates between black and white ethnic groups has been well described, has not been completely understood, and has been viewed as an artifact.Methods To quantify this incidence rate crossover, we examined data for 440653 women with invasive breast cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results database from January 1, 1975, through December 31, 2004. Data on invasive female breast cancers were stratified by race, age at diagnosis, year of diagnosis, and tumor characteristics. Standard descriptive analyses were supplemented with Poisson regression models, age-period-cohort models, and two-component mixture models. All statistical tests were two-sided.Results We observed qualitative (ie, crossing or reversing) interactions between age and race. That is, age-specific incidence rates overall (expressed as number of breast cancers per 100000 woman-years) were higher among black women (15.5) than among white women (13.1) younger than 40 years (difference = 2.4, 95% confidence interval [CI] = 2.4 to 2.4), and then, age-specific rates crossed with rates higher among white women (281.3) than among black women (239.5) aged 40 years or older (difference = 41.8, 95% CI = 41.7 to 41.9). The black-to-white incidence rate crossover was observed for all tumor characteristics assessed, although the crossover occurred at earlier ages of diagnosis for low-risk tumor characteristics than for high-risk tumor characteristics. The incidence rate crossover between ethnic groups was robust (ie, reliable and reproducible) to adjustment for calendar period and birth cohort effects in age-period-cohort models (P [Lt] .001 for difference by race).Conclusion Although this ecologic study cannot determine the individual-level factors responsible for the racial crossover in vital rates, it confirms that the age-related crossover in breast cancer incidence rates between black and white ethnic groups is a robust age-specific effect that is independent of period and cohort effects. JF - Journal of the National Cancer Institute AU - Anderson, William F AU - Rosenberg, Philip S AU - Menashe, Idan AU - Mitani, Aya AU - Pfeiffer, Ruth M AD - Affiliations of authors: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD (WFA, PSR, IM, RMP); Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT (AM), wanderso@mail.nih.gov Y1 - 2008/12/17/ PY - 2008 DA - 2008 Dec 17 SP - 1804 EP - 1814 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 24 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Age KW - Breast cancer KW - tumors KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Age-Related+Crossover+in+Breast+Cancer+Incidence+Rates+Between+Black+and+White+Ethnic+Groups&rft.au=Anderson%2C+William+F%3BRosenberg%2C+Philip+S%3BMenashe%2C+Idan%3BMitani%2C+Aya%3BPfeiffer%2C+Ruth+M&rft.aulast=Anderson&rft.aufirst=William&rft.date=2008-12-17&rft.volume=100&rft.issue=24&rft.spage=1804&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn411 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Breast cancer; tumors; Ethnic groups; Cancer DO - http://dx.doi.org/10.1093/jnci/djn411 ER - TY - JOUR T1 - Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies. AN - 69900391; 19057013 AB - Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse skin carcinogenesis both in vitro and in vivo. The current study identifies Sulfiredoxin (Srx) as a unique target of activator protein-1 (AP-1) activation and TAM67 inhibition. Manipulation of Srx levels by ShRNA or over-expression demonstrates that Srx is critical for redox homeostasis through reducing hyperoxidized peroxiredoxins. In JB6 cells, knockdown of Srx abolishes tumor promoter-induced transformation and enhances cell sensitivity to oxidative stress. Knockdown of Srx also impairs c-Jun phosphorylation, implicating a role for Srx in the feedback regulation of AP-1 activity. Screening of patient tissues by tissue microarray reveals elevated Srx expression in several types of human skin cancers. Our study indicates that Srx is a functionally significant target of AP-1 blockade that may have value in cancer prevention or treatment. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Wei, Qiou AU - Jiang, Hong AU - Matthews, Connie P AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2008/12/16/ PY - 2008 DA - 2008 Dec 16 SP - 19738 EP - 19743 VL - 105 IS - 50 KW - Peptide Fragments KW - 0 KW - Peroxides KW - Proto-Oncogene Proteins c-jun KW - RNA, Small Interfering KW - TAM67 peptide KW - Transcription Factor AP-1 KW - Oxidoreductases KW - EC 1.- KW - Oxidoreductases Acting on Sulfur Group Donors KW - EC 1.8.- KW - SRXN1 protein, human KW - EC 1.8.98.2 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Animals KW - Cysteine -- metabolism KW - Peroxides -- metabolism KW - Apoptosis KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Epidermis -- metabolism KW - RNA, Small Interfering -- genetics KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Mice KW - Promoter Regions, Genetic KW - Gene Knockdown Techniques KW - Phosphorylation KW - Oxidative Stress KW - Epidermis -- pathology KW - Skin Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic KW - Oxidoreductases -- genetics KW - Cell Transformation, Neoplastic -- pathology KW - Transcription Factor AP-1 -- metabolism KW - Skin Neoplasms -- pathology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69900391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Sulfiredoxin+is+an+AP-1+target+gene+that+is+required+for+transformation+and+shows+elevated+expression+in+human+skin+malignancies.&rft.au=Wei%2C+Qiou%3BJiang%2C+Hong%3BMatthews%2C+Connie+P%3BColburn%2C+Nancy+H&rft.aulast=Wei&rft.aufirst=Qiou&rft.date=2008-12-16&rft.volume=105&rft.issue=50&rft.spage=19738&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0810676105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-12 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9827-32 [10449779] Science. 1989 May 5;244(4904):566-9 [2541502] J Biol Chem. 2005 Feb 4;280(5):3125-8 [15590625] Nature. 2005 May 19;435(7040):347-53 [15902258] J Biol Chem. 2005 Jun 17;280(24):23319-27 [15824112] J Invest Dermatol. 2000 Dec;115(6):1108-14 [11121149] J Biol Chem. 2002 Nov 8;277(45):43175-84 [12196529] Dev Cell. 2003 Jun;4(6):879-89 [12791272] Nature. 2003 Jul 31;424(6948):561-5 [12891360] Nature. 2003 Oct 30;425(6961):980-4 [14586471] Nature. 1991 Aug 15;352(6336):635-8 [1907719] J Biol Chem. 1993 May 25;268(15):11050-6 [8496166] Genes Dev. 1993 Jul;7(7B):1309-17 [8330736] Nature. 1993 Sep 9;365(6442):179-81 [8371760] Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):609-13 [8290571] Cancer Res. 1994 Mar 1;54(5):1139-44 [8118794] Mol Carcinog. 1994 Nov;11(3):164-9 [7945805] Science. 1994 Dec 9;266(5191):1719-23 [7992057] Cell. 1995 Sep 8;82(5):721-32 [7545543] FEBS Lett. 1998 Feb 13;423(1):39-44 [9506838] Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8875-80 [15956211] J Biol Chem. 2005 Aug 5;280(31):28775-84 [15941719] Oncogene. 2005 Dec 1;24(54):8038-50 [16170382] Trends Mol Med. 2005 Dec;11(12):571-8 [16290020] J Biol Chem. 2006 May 19;281(20):14400-7 [16565085] Cancer Res. 2006 Jul 1;66(13):6800-6 [16818657] Cancer Res. 2006 Jul 15;66(14):7136-42 [16849559] Plant J. 2007 Feb;49(3):505-14 [17217469] Cancer Res. 2007 Mar 15;67(6):2430-8 [17363560] Carcinogenesis. 2007 Nov;28(11):2382-90 [17566060] Nature. 2008 Jan 3;451(7174):98-101 [18172504] Biochem J. 2008 Apr 1;411(1):191-9 [18052930] Oncogene. 2008 Aug 21;27(36):4877-87 [18454177] Cancer Prev Res (Phila). 2008 Jun;1(1):45-55 [19138935] J Biol Chem. 2004 Jan 23;279(4):2535-43 [14597634] Nat Biotechnol. 2004 Mar;22(3):326-30 [14758366] Cell. 2004 May 28;117(5):625-35 [15163410] Cell. 1974 Dec;3(4):355-9 [4442124] Cancer Res. 1978 Mar;38(3):624-34 [626967] Cell. 1987 Jun 19;49(6):741-52 [3034433] Cell. 1988 Dec 2;55(5):875-85 [3142689] J Biol Chem. 2004 Dec 3;279(49):50994-1001 [15448164] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0810676105 ER - TY - JOUR T1 - Antitumor Activity of G3139 Lipid Nanoparticles (LNPs) AN - 754551124; 13305289 AB - G3139, an antisense oligodeoxyribonucleotide (ODN) against Bcl-2, contains two CpG dinucleotides and has shown immunostimulatory activities in preclinical studies. It has been suggested that immunoactivation, rather than antisense activity, is primarily responsible for the therapeutic efficacy of G3139. Nanoparticle formulations naturally target phagocytic antigen presenting cells and therefore might enhance the immunological effects of G3139. In this study, a novel formulation of lipid nanoparticles (LNPs) encapsulating G3139 was synthesized and evaluated in mice bearing L1210 subcutaneous tumors. Intravenous injection of G3139-LNPs into mice led to increased serum levels of IL-6 and IFN-*g, promoted proliferation of natural killer (NK) cells and dendritic cells (DCs), and triggered a strong antitumor immune response in mice. The observed effects were much greater than those induced by free G3139. Correspondingly, the G3139-LNPs more effectively inhibited tumor growth and induced complete tumor regression in some mice. In contrast, free G3139 was ineffective in tumor growth inhibition and did not prolong survival of the tumor-bearing mice. These results suggest that G3139-LNPs are a potential immunomodulatory agent and may have applications in cancer therapy. JF - Molecular Pharmaceutics AU - Pan, Xiaogang AU - Chen, Li AU - Liu, Shujun AU - Yang, Xiaojuan AU - Gao, Jian-Xin AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, NSF Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), Department of Pathology, Department of Internal Medicine, College of Medicine and Public Health, and NCI Comprehensive Cancer Center (CCC), The Ohio State University, Columbus, Ohio 43210 Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 211 EP - 220 PB - American Chemical Society VL - 6 IS - 1 SN - 1543-8384, 1543-8384 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Intravenous administration KW - Lipids KW - Natural killer cells KW - Survival KW - CpG islands KW - Tumors KW - Immunomodulation KW - Oligonucleotides KW - Cancer KW - Serum levels KW - Antisense oligonucleotides KW - Dendritic cells KW - Antisense KW - Phagocytes KW - Immunostimulation KW - Antigen-presenting cells KW - Bcl-2 protein KW - Cell proliferation KW - nanoparticles KW - Antitumor activity KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754551124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Antitumor+Activity+of+G3139+Lipid+Nanoparticles+%28LNPs%29&rft.au=Pan%2C+Xiaogang%3BChen%2C+Li%3BLiu%2C+Shujun%3BYang%2C+Xiaojuan%3BGao%2C+Jian-Xin%3BLee%2C+Robert+J&rft.aulast=Pan&rft.aufirst=Xiaogang&rft.date=2008-12-15&rft.volume=6&rft.issue=1&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp800146j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Intravenous administration; Lipids; Natural killer cells; Survival; Tumors; CpG islands; Oligonucleotides; Immunomodulation; Cancer; Serum levels; Dendritic cells; Antisense oligonucleotides; Antisense; Phagocytes; Immunostimulation; Bcl-2 protein; Antigen-presenting cells; Cell proliferation; nanoparticles; Antitumor activity DO - http://dx.doi.org/10.1021/mp800146j ER - TY - JOUR T1 - Transferrin Receptor-Targeted Lipid Nanoparticles for Delivery of an Antisense Oligodeoxyribonucleotide against Bcl-2 AN - 754549980; 13305290 AB - Antisense oligonucleotide G3139-mediated down-regulation of Bcl-2 is a potential strategy for overcoming chemoresistance in leukemia. However, the limited efficacy shown in recent clinical trials calls attention to the need for further development of novel and more efficient delivery systems. In order to address this issue, transferrin receptor (TfR)-targeted, protamine-containing lipid nanoparticles (Tf-LNs) were synthesized as delivery vehicles for G3139. The LNs were produced by an ethanol dilution method, and lipid-conjugated Tf ligand was then incorporated by a postinsertion method. The resulting Tf-LNs had a mean particle diameter of 90 nm and G3139 loading efficiency of 90.4%. Antisense delivery efficiency of Tf-LNs was evaluated in K562, MV4-11, and Raji leukemia cell lines. The results showed that Tf-LNs were more effective than nontargeted LNs and free G3139 (p < 0.05) in decreasing Bcl-2 expression (by up to 62% at the mRNA level in K562 cells) and in inducing caspase-dependent apoptosis. In addition, Bcl-2 down-regulation and apoptosis induced by Tf-LN G3139 were shown to be blocked by excess free Tf and thus were TfR-dependent. Cell lines with higher TfR expression also showed greater Bcl-2 down-regulation. Furthermore, up-regulation of TfR expression in leukemia cells by iron chelator deferoxamine resulted in a further increase in antisense effect (up to 79% Bcl-2 reduction in K562 at the mRNA level) and in caspase-dependent apoptosis (by 3-fold) by Tf-LN. Tf-LN-mediated delivery combined with TfR up-regulation by deferoxamine appears to be a potentially promising strategy for enhancing the delivery efficiency and therapeutic efficacy of antisense oligonucleotides. JF - Molecular Pharmaceutics AU - Yang, Xiaojuan AU - Koh, Chee Guan AU - Liu, Shujun AU - Pan, Xiaogang AU - Santhanam, Ramasamy AU - Yu, Bo AU - Peng, Yong AU - Pang, Jiuxia AU - Golan, Sharon AU - Talmon, Yeshayahu AU - Jin, Yan AU - Muthusamy, Natarajan AU - Byrd, John C AU - Chan, Kenneth K AU - Lee, L James AU - Marcucci, Guido AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, NSF Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), Department of Chemical and Biomolecular Engineering, NCI Comprehensive Cancer Center (CCC), Department of Molecular and Cellular Biochemistry, and Division of Hematology and Oncology, The Ohio State University, Columbus, Ohio 43210, and Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 221 EP - 230 PB - American Chemical Society VL - 6 IS - 1 SN - 1543-8384, 1543-8384 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Lipids KW - Chemoresistance KW - Chelating agents KW - Clinical trials KW - mRNA KW - Antisense oligonucleotides KW - Tumor cell lines KW - Transferrin KW - Transferrin receptors KW - Bcl-2 protein KW - Iron KW - nanoparticles KW - Deferoxamine KW - Ethanol KW - W 30915:Pharmaceuticals & Vaccines KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754549980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Transferrin+Receptor-Targeted+Lipid+Nanoparticles+for+Delivery+of+an+Antisense+Oligodeoxyribonucleotide+against+Bcl-2&rft.au=Yang%2C+Xiaojuan%3BKoh%2C+Chee+Guan%3BLiu%2C+Shujun%3BPan%2C+Xiaogang%3BSanthanam%2C+Ramasamy%3BYu%2C+Bo%3BPeng%2C+Yong%3BPang%2C+Jiuxia%3BGolan%2C+Sharon%3BTalmon%2C+Yeshayahu%3BJin%2C+Yan%3BMuthusamy%2C+Natarajan%3BByrd%2C+John+C%3BChan%2C+Kenneth+K%3BLee%2C+L+James%3BMarcucci%2C+Guido%3BLee%2C+Robert+J&rft.aulast=Yang&rft.aufirst=Xiaojuan&rft.date=2008-12-15&rft.volume=6&rft.issue=1&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp800149s LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Apoptosis; Chemoresistance; Lipids; Chelating agents; Clinical trials; mRNA; Antisense oligonucleotides; Transferrin; Tumor cell lines; Transferrin receptors; Bcl-2 protein; nanoparticles; Iron; Deferoxamine; Ethanol DO - http://dx.doi.org/10.1021/mp800149s ER - TY - JOUR T1 - 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. AN - 69894588; 18785202 AB - 15-LOX-1 and its metabolites are involved in colorectal cancer. Recently, we reported that 15-LOX-1 overexpression in HCT-116 human colorectal cancer cells inhibited cell growth by induction of p53 phosphorylation (4). To determine whether the 15-LOX-1 protein or its metabolites are responsible for phosphorylation of p53 in HCT-116 cells, we used HCT-116 cells that expressed a mutant 15-LOX-1. The mutant 15-LOX-1 enzyme, with a substitution of Leu at residue His361, was devoid of enzymatic activity. HCT-116 cells transiently transfected with either native or mutant 15-LOX-1 showed an increase in p53 phosphorylation and an increase in the expression of downstream genes. Thus, 15-LOX-1 induces p53 phosphorylation independent of enzymatic activity. Treatment of A549 human lung carcinoma cells with IL-4 increased the expression of 15-LOX-1 and also increased the expression of downstream targets of p53. This confirmed that the activation of p53 was also observed in wild-type cells expressing physiological 15-LOX-1. Immunoprecipitation experiments revealed that 15-LOX-1 interacts with, and binds to, DNA-dependent protein kinase (DNA-PK). The binding of 15-LOX-1 to DNA-PK caused an approximate 3.0-fold enhancement in kinase activity, resulting in increased p53 phosphorylation at Ser15. Knockdown of DNA-PK by small interfering RNA (siRNA) significantly reduced p53 phosphorylation. Furthermore, confocal microscopy demonstrated a colocalization of 15-LOX and DNA-PK in the cells. We propose that the 15-LOX-1 protein binds to DNA-PK, increasing its kinase activity and results in downstream activation of the tumor suppressor p53, thus revealing a new mechanism by which lipoxygenases (LOX) may influence the phenotype of tumor cells. (c) 2008 Wiley-Liss, Inc. JF - International journal of cancer AU - Zhu, Hong AU - Glasgow, Wayne AU - George, Margaret D AU - Chrysovergis, Kali AU - Olden, Kenneth AU - Roberts, John D AU - Eling, Thomas AD - Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 2741 EP - 2749 VL - 123 IS - 12 KW - RNA, Small Interfering KW - 0 KW - Tumor Suppressor Protein p53 KW - DNA KW - 9007-49-2 KW - Linoleic Acid KW - 9KJL21T0QJ KW - Arachidonate 15-Lipoxygenase KW - EC 1.13.11.33 KW - Protein Kinases KW - EC 2.7.- KW - Index Medicus KW - Phenotype KW - Gene Expression Regulation, Neoplastic KW - Blotting, Western KW - Phosphorylation KW - Linoleic Acid -- metabolism KW - Transfection KW - Humans KW - DNA -- metabolism KW - Protein Kinases -- genetics KW - Immunoprecipitation KW - HCT116 Cells KW - Fluorescent Antibody Technique KW - Lung Neoplasms -- enzymology KW - Arachidonate 15-Lipoxygenase -- metabolism KW - Colorectal Neoplasms -- metabolism KW - Colorectal Neoplasms -- enzymology KW - Tumor Suppressor Protein p53 -- metabolism KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69894588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=15-lipoxygenase-1+activates+tumor+suppressor+p53+independent+of+enzymatic+activity.&rft.au=Zhu%2C+Hong%3BGlasgow%2C+Wayne%3BGeorge%2C+Margaret+D%3BChrysovergis%2C+Kali%3BOlden%2C+Kenneth%3BRoberts%2C+John+D%3BEling%2C+Thomas&rft.aulast=Zhu&rft.aufirst=Hong&rft.date=2008-12-15&rft.volume=123&rft.issue=12&rft.spage=2741&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.23855 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prostaglandins Leukot Essent Fatty Acids. 2001 Apr-May;64(4-5):217-25 [11418015] J Biol Chem. 2002 Jul 26;277(30):27360-6 [12004065] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9968-73 [12909723] J Immunol. 2003 Jan 15;170(2):887-94 [12517954] J Biol Chem. 2004 Jul 9;279(28):29023-30 [15123652] Immunol Rev. 2004 Aug;200:132-41 [15242401] J Biol Chem. 1990 Mar 25;265(9):5113-20 [2318885] Mol Cell Biol. 1992 Nov;12(11):5041-9 [1406679] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6148-52 [9177185] Cell. 1997 Oct 31;91(3):325-34 [9363941] Int J Biochem Cell Biol. 1997 Jul;29(7):935-8 [9375373] Nat Struct Biol. 1997 Dec;4(12):1003-9 [9406550] Blood. 1998 Jan 1;91(1):64-74 [9414270] J Biol Chem. 1998 Aug 21;273(34):21569-77 [9705287] Science. 1998 Sep 11;281(5383):1677-9 [9733515] Cancer Res. 1998 Oct 1;58(19):4375-82 [9766667] Genes Dev. 1999 Jan 15;13(2):152-7 [9925639] Carcinogenesis. 1999 Oct;20(10):1985-95 [10506115] Biochemistry. 2004 Dec 7;43(48):15296-302 [15568822] Neoplasia. 2004 Nov-Dec;6(6):821-30 [15720809] Ann Surg. 2005 Jun;241(6):941-6; discussion 946-7 [15912043] Mol Cancer Res. 2005 Sep;3(9):511-7 [16179498] J Biol Chem. 2006 Jan 13;281(2):1196-204 [16251187] Oncogene. 2006 Feb 23;25(8):1225-41 [16288226] Neoplasia. 2006 Jun;8(6):510-22 [16820097] Nat Rev Cancer. 2006 Dec;6(12):909-23 [17128209] Biochim Biophys Acta. 2006 Dec;1761(12):1498-505 [17052953] Exp Cell Res. 2006 Dec 10;312(20):4056-69 [17056038] Curr Drug Metab. 2006 Dec;7(8):853-72 [17168687] J Gastroenterol Hepatol. 2007 Dec;22(12):2324-9 [17559385] Biochemistry. 2000 Mar 28;39(12):3185-91 [10727209] Int J Cancer. 2000 Jul 1;87(1):37-43 [10861450] J Natl Cancer Inst. 2000 Jul 19;92(14):1136-42 [10904086] J Biol Chem. 2001 May 11;276(19):16520-7 [11297527] Science. 2001 Jun 15;292(5524):2083-6 [11408659] Prostaglandins Leukot Essent Fatty Acids. 2004 Jan;70(1):7-15 [14643174] J Biol Chem. 2004 Jan 30;279(5):3717-25 [14594811] Methods Mol Biol. 2004;284:1-14 [15173605] Carcinogenesis. 2001 Nov;22(11):1765-73 [11698337] Curr Urol Rep. 2002 Jun;3(3):207-14 [12084190] Carcinogenesis. 2003 Feb;24(2):243-7 [12584173] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.23855 ER - TY - JOUR T1 - Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus). AN - 69870302; 18848574 AB - Alkaloid profiles in skin of poison frogs/toads (Dendrobatidae, Mantellidae, Bufonidae, and Myobatrachidae) are highly dependent on diet and hence on the nature of habitat. Extracts of the two species of toads (Melanophryniscus klappenbachi and Melanophryniscus cupreuscapularis) from similar habitats in the Corrientes/Chaco Provinces of Argentina have similar profiles of alkaloids, which differ considerably in profiles from other Melanophryniscus species from Brazil, Uruguay and Argentina. Structures of two major alkaloids 239Q (1) and 275I (2) were determined by mass, FTIR, and NMR spectral analysis as 5Z,9Z-3-(1-hydroxybutyl)-5-propylindolizidine and 6Z,10E-4,6-di(pent-4-enyl) quinolizidine, respectively. A third alkaloid, 249F (3), is postulated to be a homopumiliotoxin with an unprecedented conjugated exocyclic diene moiety. JF - Toxicon : official journal of the International Society on Toxinology AU - Daly, John W AU - Garraffo, H Martin AU - Spande, Thomas F AU - Yeh, Herman J C AU - Peltzer, Paola M AU - Cacivio, Pedro M AU - Baldo, J Diego AU - Faivovich, Julián AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 858 EP - 870 VL - 52 IS - 8 SN - 0041-0101, 0041-0101 KW - Alkaloids KW - 0 KW - Indolizidines KW - Quinolizidines KW - Index Medicus KW - Molecular Structure KW - Gastrointestinal Contents -- chemistry KW - Spectroscopy, Fourier Transform Infrared KW - Animals KW - Alkaloids -- chemistry KW - Argentina KW - Nuclear Magnetic Resonance, Biomolecular KW - Gas Chromatography-Mass Spectrometry KW - Alkaloids -- isolation & purification KW - Alkaloids -- analysis KW - Indolizidines -- chemistry KW - Skin -- chemistry KW - Bufonidae -- metabolism KW - Quinolizidines -- chemistry KW - Quinolizidines -- analysis KW - Indolizidines -- isolation & purification KW - Indolizidines -- analysis KW - Quinolizidines -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69870302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Indolizidine+239Q+and+quinolizidine+275I.+Major+alkaloids+in+two+Argentinian+bufonid+toads+%28Melanophryniscus%29.&rft.au=Daly%2C+John+W%3BGarraffo%2C+H+Martin%3BSpande%2C+Thomas+F%3BYeh%2C+Herman+J+C%3BPeltzer%2C+Paola+M%3BCacivio%2C+Pedro+M%3BBaldo%2C+J+Diego%3BFaivovich%2C+Juli%C3%A1n&rft.aulast=Daly&rft.aufirst=John&rft.date=2008-12-15&rft.volume=52&rft.issue=8&rft.spage=858&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2008.08.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-12 N1 - Date created - 2008-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicon. 2005 Nov;46(6):641-50 [16157358] J Nat Prod. 2005 Oct;68(10):1556-75 [16252926] J Chem Ecol. 2006 Apr;32(4):795-814 [16718571] Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jan;144(4):398-402 [17208052] J Nat Prod. 2007 Feb;70(2):160-8 [17243727] J Chem Ecol. 2007 Apr;33(4):871-87 [17333373] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8885-90 [17502597] Toxicon. 2007 Nov;50(6):757-78 [17706737] Toxicon. 1978;16(2):163-88 [635931] J Nat Prod. 2002 Apr;65(4):439-47 [11975476] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13996-4001 [12381780] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11092-7 [12960405] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12792-7 [14555763] Mol Phylogenet Evol. 2004 May;31(2):462-75 [15062788] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4346-51 [15070720] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8045-50 [15128938] J Nat Prod. 2004 Aug;67(8):1211-5 [15332834] Science. 1967 May 19;156(3777):970-3 [6023266] Syst Zool. 1967 Dec;16(4):328-42 [6064273] J Am Chem Soc. 1969 Jul 2;91(14):3931-8 [5814950] Experientia. 1971 May 15;27(5):506 [5132572] J Chem Ecol. 2005 Oct;31(10):2403-15 [16195851] Am Nat. 2005 Jan;165(1):56-69 [15729640] Toxicon. 2004 Dec 15;44(8):805-15 [15530960] Science. 1975 Jul 11;189(4197):151-2 [1138374] J Morphol. 1998 Jul;237(1):19-32 [9642789] Toxicon. 1997 May;35(5):705-9 [9203295] Toxicon. 1995 Feb;33(2):246-9 [7597728] Toxicon. 1994 Mar;32(3):279-85 [8016850] J Nat Prod. 1993 Mar;56(3):357-73 [8482947] Steroids. 1986 Sep-Oct;48(3-4):251-7 [3127947] Chem Pharm Bull (Tokyo). 1986 Aug;34(8):3454-7 [3791519] Toxicon. 1984;22(6):905-19 [6523513] Chem Pharm Bull (Tokyo). 1980 May;28(5):1559-62 [7408047] Science. 1980 May 2;208(4443):503-5 [6245447] Nat Prod Rep. 1998 Aug;15(4):397-413 [9736996] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxicon.2008.08.016 ER - TY - JOUR T1 - A validated gas chromatographic-electron impact ionization mass spectrometric method for methamphetamine, methylenedioxymethamphetamine (MDMA), and metabolites in mouse plasma and brain. AN - 69845804; 19026602 AB - A method was developed and fully validated for simultaneous quantification of methamphetamine (MAMP), amphetamine, hydroxy-methamphetamine, methylenedioxymethamphetamine (MDMA, ecstasy), methylenedioxyamphetamine, 3-hydroxy-4-methoxy-methamphetamine, and 3-hydroxy-4-methoxy-amphetamine in 100 microL mouse plasma and 7.5mg brain. Solid phase extraction and gas chromatography-electron impact ionization mass spectrometry in selected-ion monitoring mode achieved plasma linear ranges of 10-20 to 20,000 ng/mL and 0.1-0.2 to 200 ng/mg in brain. Recoveries were greater than 91%, bias 92.3-110.4%, and imprecision less than 5.3% coefficient of variation. This method was used for measuring MAMP and MDMA and metabolites in plasma and brain during mouse neurotoxicity studies. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Scheidweiler, Karl B AU - Barnes, Allan J AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 266 EP - 276 VL - 876 IS - 2 SN - 1570-0232, 1570-0232 KW - Methamphetamine KW - 44RAL3456C KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Humans KW - Brain Chemistry KW - Mice KW - Hydrolysis KW - Male KW - Spectrometry, Mass, Electrospray Ionization -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - N-Methyl-3,4-methylenedioxyamphetamine -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- blood KW - Methamphetamine -- blood KW - Methamphetamine -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- analysis KW - Methamphetamine -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69845804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=A+validated+gas+chromatographic-electron+impact+ionization+mass+spectrometric+method+for+methamphetamine%2C+methylenedioxymethamphetamine+%28MDMA%29%2C+and+metabolites+in+mouse+plasma+and+brain.&rft.au=Scheidweiler%2C+Karl+B%3BBarnes%2C+Allan+J%3BHuestis%2C+Marilyn+A&rft.aulast=Scheidweiler&rft.aufirst=Karl&rft.date=2008-12-15&rft.volume=876&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/10.1016%2Fj.jchromb.2008.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 1997 Dec;19(6):1285-96 [9427251] J Pharmacol Exp Ther. 1998 Mar;284(3):1040-7 [9495865] Mol Pharmacol. 1998 Apr;53(4):649-55 [9547354] J Chromatogr B Biomed Sci Appl. 1999 Feb 19;723(1-2):221-32 [10080649] Br J Pharmacol. 2005 Jan;144(2):231-41 [15665862] Clin Chem. 2005 Oct;51(10):1811-22 [16099938] Ann N Y Acad Sci. 2000 Sep;914:104-11 [11085313] J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 17;832(1):81-9 [16436334] J Psychopharmacol. 2006 May;20(3):456-63 [16574720] Xenobiotica. 2006 Feb-Mar;36(2-3):259-67 [16702115] AAPS J. 2006;8(2):E337-47 [16796384] J Neurochem. 2006 Jul;98(2):495-505 [16749908] Psychopharmacology (Berl). 2007 Jan;189(4):407-24 [16541247] J Anal Toxicol. 2006 Oct;30(8):563-9 [17132253] Annu Rev Pharmacol Toxicol. 2007;47:681-98 [17209801] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] J Anal Toxicol. 2007 Apr;31(3):138-43 [17579960] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):262-70 [17646137] Biol Psychiatry. 2007 Sep 15;62(6):669-79 [17306775] Biomed Chromatogr. 2007 Oct;21(10):1016-22 [17474141] Clin Chem. 2008 Feb;54(2):379-87 [18089653] Xenobiotica. 2008 Mar;38(3):314-24 [18274959] J Pharm Sci. 2008 Apr;97(4):1593-605 [17724664] Drug Alcohol Rev. 2008 May;27(3):236-42 [18368604] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):78-83 [18396472] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 15;874(1-2):119-24 [18829400] J Neurosci. 1999 Nov 15;19(22):10107-15 [10559418] J Pharm Biomed Anal. 1999 Dec;21(4):739-47 [10701939] Neurology. 2000 Mar 28;54(6):1344-9 [10746608] Mol Pharmacol. 2000 Dec;58(6):1247-56 [11093760] Neuroscience. 2001;107(2):265-74 [11731100] Drug Alcohol Depend. 2002 Apr 1;66(2):147-59 [11906802] J Anal Toxicol. 2002 Apr;26(3):157-65 [11991532] Neurosci Res. 2002 Jul;43(3):251-7 [12103443] Clin Chem. 2002 Sep;48(9):1472-85 [12194924] Rapid Commun Mass Spectrom. 2003;17(4):330-6 [12569443] J Anal Toxicol. 2003 Mar;27(2):78-87 [12670001] Brain Res Brain Res Rev. 2003 May;42(2):155-68 [12738056] J Mass Spectrom. 2003 Jun;38(6):659-76 [12827635] J Neurochem. 2003 Jul;86(2):413-21 [12871582] Pharmacol Rev. 2003 Sep;55(3):463-508 [12869661] FASEB J. 2003 Oct;17(13):1775-88 [14519657] Biomed Chromatogr. 2003 Oct;17(7):471-6 [14598332] J Anal Toxicol. 2003 Nov-Dec;27(8):552-9 [14670133] J Neurosci. 2004 Mar 3;24(9):2212-25 [14999072] Psychopharmacology (Berl). 2004 May;173(3-4):310-7 [14747902] Psychopharmacology (Berl). 2004 May;173(3-4):249-63 [15083264] Biol Mass Spectrom. 1993 Jul;22(7):403-11 [8102882] J Chromatogr B Biomed Appl. 1995 Feb 17;664(2):449-57 [7780602] J Anal Toxicol. 1996 Oct;20(6):432-40 [8889680] J Neurochem. 1997 Aug;69(2):780-90 [9231739] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jchromb.2008.11.001 ER - TY - JOUR T1 - Age, sex, and race influence single-strand break repair capacity in a human population. AN - 69843217; 18845243 AB - Recently, we developed an improved comet assay protocol for evaluating single-strand break repair capacity (SSB-RC) in unstimulated cryopreserved human peripheral blood mononuclear cells (PBMCs). This methodology facilitates control of interexperimental variability [A.R. Trzeciak, J. Barnes, M.K. Evans, A modified alkaline comet assay for measuring DNA repair capacity in human populations. Radiat. Res. 169 (2008) 110-121]. The fast component of SSB repair (F-SSB-RC) was assessed using a novel parameter, the initial rate of DNA repair, and the widely used half-time of DNA repair. The slow component of SSB repair (S-SSB-RC) was estimated using the residual DNA damage after 60 min. We have examined repair of gamma-radiation-induced DNA damage in PBMCs from four age-matched groups of male and female whites and African-Americans between ages 30 and 64. There is an increase in F-SSB-RC with age in white females (P<0.01) and nonsignificant decrease in F-SSB-RC in African-American females (P=0.061). F-SSB-RC is lower in white females than in white males (P<0.01). There is a decrease in F-SSB-RC with age in African-American females as compared to white females (P<0.002) and African-American males (nonsignificant, P=0.059). Age, sex, and race had a similar effect on intercellular variability of DNA damage in gamma-irradiated and repairing PBMCs. Our findings suggest that age, sex, and race influence SSB-RC as measured by the alkaline comet assay. SSB-RC may be a useful clinical biomarker. JF - Free radical biology & medicine AU - Trzeciak, Andrzej R AU - Barnes, Janice AU - Ejiogu, Ngozi AU - Foster, Kamala AU - Brant, Larry J AU - Zonderman, Alan B AU - Evans, Michele K AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 1631 EP - 1641 VL - 45 IS - 12 SN - 0891-5849, 0891-5849 KW - DNA, Single-Stranded KW - 0 KW - Index Medicus KW - Age Factors KW - Leukocytes, Mononuclear -- radiation effects KW - Sex Factors KW - Gamma Rays KW - Humans KW - African Americans KW - Comet Assay -- methods KW - European Continental Ancestry Group KW - Adult KW - Leukocytes, Mononuclear -- metabolism KW - Middle Aged KW - Female KW - Male KW - Continental Population Groups -- genetics KW - DNA, Single-Stranded -- genetics KW - DNA Repair KW - DNA, Single-Stranded -- analysis KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69843217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Age%2C+sex%2C+and+race+influence+single-strand+break+repair+capacity+in+a+human+population.&rft.au=Trzeciak%2C+Andrzej+R%3BBarnes%2C+Janice%3BEjiogu%2C+Ngozi%3BFoster%2C+Kamala%3BBrant%2C+Larry+J%3BZonderman%2C+Alan+B%3BEvans%2C+Michele+K&rft.aulast=Trzeciak&rft.aufirst=Andrzej&rft.date=2008-12-15&rft.volume=45&rft.issue=12&rft.spage=1631&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.08.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-23 N1 - Date created - 2008-11-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mutagenesis. 2006 May;21(3):173-8 [16613912] Environ Mol Mutagen. 2006 May;47(4):260-70 [16470524] Mutat Res. 2006 Jun 16;605(1-2):7-16 [16621680] Biochem Biophys Res Commun. 2006 Jun 30;345(2):726-33 [16696946] Environ Res. 2006 Oct;102(2):181-96 [16828737] DNA Repair (Amst). 2007 Jan 4;6(1):45-60 [16982217] Nat Protoc. 2007;2(5):1084-104 [17546000] Age Ageing. 2007 Sep;36(5):521-6 [17913757] Radiat Res. 2008 Jan;169(1):110-21 [18159959] Radiat Environ Biophys. 2001 Mar;40(1):83-9 [11357715] Nucleic Acids Res. 2002 Jan 15;30(2):E1 [11788727] Cancer Res. 2002 May 15;62(10):2791-7 [12019155] Br J Radiol. 2002 Jul;75(895):608-14 [12145135] Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(5):1216-25 [12654430] Acta Biochim Pol. 2003;50(1):181-90 [12673358] Carcinogenesis. 2003 May;24(5):883-9 [12771032] Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):689-98 [12917198] Mutat Res. 2003 Nov 10;541(1-2):1-8 [14568289] Cytogenet Genome Res. 2004;104(1-4):14-20 [15162010] Radiat Environ Biophys. 1983;22(1):3-19 [6611843] Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Nov;50(5):893-908 [3490451] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Radiat Res. 1988 Dec;116(3):511-25 [3060896] Radiat Res. 1990 Apr;122(1):86-94 [2320728] Mutat Res. 1990 May-Jul;237(3-4):123-30 [2233818] Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1614-8 [8434025] Mutat Res. 1993 Oct;294(3):275-83 [7692267] J Invest Dermatol. 1997 Feb;108(2):154-9 [9008227] Mutat Res. 1997 Jan 31;383(1):71-80 [9042421] Mutat Res. 1997 Mar 21;374(2):261-8 [9100849] Mutat Res. 1997 Jun;386(3):315-34 [9219569] Mutat Res. 1998 Mar 16;413(2):111-9 [9639687] Int J Radiat Biol. 1998 Jun;73(6):649-60 [9690683] J Biol Chem. 1998 Sep 18;273(38):24822-31 [9733786] Environ Mol Mutagen. 2000;35(3):206-21 [10737956] Mutat Res. 2000 Sep 20;469(2):181-97 [10984679] Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S77-91 [11041079] J Natl Cancer Inst. 2000 Nov 1;92(21):1764-72 [11058619] Int J Cancer. 2001 Mar 20;95(2):86-91 [11241317] FASEB J. 1998 Oct;12(13):1397-400 [9761783] Radiat Res. 1998 Nov;150(5 Suppl):S42-51 [9806608] Mutagenesis. 2006 May;21(3):205-11 [16613913] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.08.031 ER - TY - JOUR T1 - Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. AN - 69839286; 18782848 AB - The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, the genetic deficiency of the glycogen-degrading lysosomal enzyme acid-alpha glucosidase. Accumulation of lysosomal glycogen, presumably transported from the cytoplasm by the autophagic pathway, occurs in multiple tissues, but pathology is most severe in skeletal and cardiac muscle. Skeletal muscle pathology also involves massive autophagic buildup in the core of myofibers. To determine if glycogen reaches the lysosome via autophagy and to ascertain whether autophagic buildup in Pompe disease is a consequence of induction of autophagy and/or reduced turnover due to defective fusion with lysosomes, we generated muscle-specific autophagy-deficient Pompe mice. We have demonstrated that autophagy is not required for glycogen transport to lysosomes in skeletal muscle. We have also found that Pompe disease involves induction of autophagy but manifests as a functional deficiency of autophagy because of impaired autophagosomal-lysosomal fusion. As a result, autophagic substrates, including potentially toxic aggregate-prone ubiquitinated proteins, accumulate in Pompe myofibers and may cause profound muscle damage. JF - Human molecular genetics AU - Raben, Nina AU - Hill, Victoria AU - Shea, Lauren AU - Takikita, Shoichi AU - Baum, Rebecca AU - Mizushima, Noboru AU - Ralston, Evelyn AU - Plotz, Paul AD - Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA. rabenn@arb.niams.nih.gov Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 3897 EP - 3908 VL - 17 IS - 24 KW - Proteins KW - 0 KW - alpha-Glucosidases KW - EC 3.2.1.20 KW - Index Medicus KW - Animals KW - Mice KW - alpha-Glucosidases -- deficiency KW - Mice, Transgenic KW - alpha-Glucosidases -- genetics KW - Male KW - Female KW - Mice, Knockout KW - Autophagy -- genetics KW - Muscle, Skeletal -- pathology KW - Muscular Diseases -- pathology KW - Ubiquitination -- genetics KW - Glycogen Storage Disease Type II -- genetics KW - Muscle, Skeletal -- enzymology KW - Proteins -- metabolism KW - Proteins -- genetics KW - Muscular Diseases -- metabolism KW - Glycogen Storage Disease Type II -- enzymology KW - Muscular Diseases -- etiology KW - Proteins -- adverse effects KW - Glycogen Storage Disease Type II -- pathology KW - Muscle, Skeletal -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Suppression+of+autophagy+in+skeletal+muscle+uncovers+the+accumulation+of+ubiquitinated+proteins+and+their+potential+role+in+muscle+damage+in+Pompe+disease.&rft.au=Raben%2C+Nina%3BHill%2C+Victoria%3BShea%2C+Lauren%3BTakikita%2C+Shoichi%3BBaum%2C+Rebecca%3BMizushima%2C+Noboru%3BRalston%2C+Evelyn%3BPlotz%2C+Paul&rft.aulast=Raben&rft.aufirst=Nina&rft.date=2008-12-15&rft.volume=17&rft.issue=24&rft.spage=3897&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=1460-2083&rft_id=info:doi/10.1093%2Fhmg%2Fddn292 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2008-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Mol Genet. 2008 Jan 1;17(1):119-29 [17913701] Cell. 2007 Dec 14;131(6):1149-63 [18083104] Nature. 2008 Feb 28;451(7182):1069-75 [18305538] Traffic. 2008 Apr;9(4):574-87 [18182013] Autophagy. 2008 May;4(4):524-6 [18367868] Autophagy. 2008 Jul;4(5):727-30 [18437051] J Biol Chem. 2008 Aug 15;283(33):22847-57 [18524774] J Pathol. 1999 Nov;189(3):416-24 [10547605] EMBO J. 2000 Nov 1;19(21):5720-8 [11060023] J Cell Biol. 2001 Feb 19;152(4):657-68 [11266458] Science. 2001 Nov 23;294(5547):1704-8 [11679633] Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14440-5 [11717410] Curr Opin Neurol. 2002 Oct;15(5):525-31 [12351995] FASEB J. 2002 Nov;16(13):1697-712 [12409312] Curr Neurol Neurosci Rep. 2003 Jan;3(1):64-9 [12507414] Cell Struct Funct. 2002 Dec;27(6):421-9 [12576635] Biochim Biophys Acta. 2003 Mar 20;1637(2):164-70 [12633905] Biochem Biophys Res Commun. 2004 Jan 9;313(2):453-8 [14684184] FASEB J. 2004 Jan;18(1):39-51 [14718385] Microsc Res Tech. 2004 Feb 1;63(2):87-93 [14722905] Oncogene. 2004 Mar 15;23(11):2057-70 [15021893] Dev Cell. 2004 Apr;6(4):463-77 [15068787] Cell. 2004 Apr 30;117(3):399-412 [15109499] Microsc Res Tech. 2004 May 1;64(1):10-20 [15287014] Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18 [15325588] J Cell Biol. 1972 Jan;52(1):41-51 [4331300] Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(1):23-36 [6199885] J Morphol. 1994 Aug;221(2):177-90 [7932768] J Biol Chem. 1998 Jul 24;273(30):19086-92 [9668092] Nucleic Acids Res. 1999 Oct 1;27(19):e27 [10481039] Biochim Biophys Acta. 2004 Nov 29;1695(1-3):89-111 [15571811] Mol Ther. 2005 Jan;11(1):48-56 [15585405] J Cell Sci. 2005 Jan 1;118(Pt 1):7-18 [15615779] Nature. 2004 Dec 23;432(7020):1032-6 [15525940] J Biomech. 2005 May;38(5):1035-43 [15797585] J Cell Biol. 2005 May 9;169(3):425-34 [15866887] Histol Histopathol. 2005 Jul;20(3):689-96 [15944916] J Neuropathol Exp Neurol. 2005 Jun;64(6):513-22 [15977643] J Cell Biol. 2005 Nov 21;171(4):603-14 [16286508] Am J Pathol. 2005 Dec;167(6):1713-28 [16314482] Traffic. 2006 Feb;7(2):129-45 [16420522] Ann Neurol. 2006 Apr;59(4):700-8 [16532490] Nature. 2006 Jun 15;441(7095):885-9 [16625204] Nature. 2006 Jun 15;441(7095):880-4 [16625205] J Pediatr. 2006 Jul;149(1):89-97 [16860134] Pathol Res Pract. 2006;202(9):631-8 [16781826] Autophagy. 2006 Oct-Dec;2(4):318-20 [16874053] J Biol Chem. 2006 Nov 24;281(47):36303-16 [16963441] Lab Invest. 2006 Dec;86(12):1208-20 [17075580] Mol Ther. 2006 Dec;14(6):831-9 [17008131] Curr Neurol Neurosci Rep. 2007 Jan;7(1):71-7 [17217857] Autophagy. 2007 May-Jun;3(3):259-62 [17329960] Hum Mol Genet. 2007 Apr 15;16(8):919-28 [17329348] Mol Genet Metab. 2007 Aug;91(4):343-51 [17572127] J Biol Chem. 2007 Aug 17;282(33):24131-45 [17580304] Mol Biol Cell. 2007 Oct;18(10):3952-65 [17686993] Autophagy. 2007 Nov-Dec;3(6):546-52 [17592248] Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7 [17712358] Autophagy. 2008 Feb;4(2):151-75 [18188003] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/hmg/ddn292 ER - TY - JOUR T1 - Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir. AN - 69820643; 18991509 AB - We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections. This case highlights the potential of ritonavir interactions even with local injections of a corticosteroid. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Ramanathan, Roshan AU - Pau, Alice K AU - Busse, Kristin H AU - Zemskova, Marina AU - Nieman, Lynnette AU - Kwan, Richard AU - Hammer, Jean H AU - Mican, JoAnn M AU - Maldarelli, Frank AD - Clinical Parasitology Unit and Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ramanathanr@niaid.nih.gov Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - e97 EP - e99 VL - 47 IS - 12 KW - Pyrimidinones KW - 0 KW - Triamcinolone KW - 1ZK20VI6TY KW - Lopinavir KW - 2494G1JF75 KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - Drug Interactions KW - HIV-1 -- isolation & purification KW - Humans KW - Adult KW - Male KW - Ritonavir -- therapeutic use KW - Triamcinolone -- adverse effects KW - Iatrogenic Disease KW - HIV Infections -- complications KW - Triamcinolone -- administration & dosage KW - HIV Infections -- drug therapy KW - Pyrimidinones -- therapeutic use KW - Cushing Syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69820643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Iatrogenic+Cushing+syndrome+after+epidural+triamcinolone+injections+in+an+HIV+type+1-infected+patient+receiving+therapy+with+ritonavir-lopinavir.&rft.au=Ramanathan%2C+Roshan%3BPau%2C+Alice+K%3BBusse%2C+Kristin+H%3BZemskova%2C+Marina%3BNieman%2C+Lynnette%3BKwan%2C+Richard%3BHammer%2C+Jean+H%3BMican%2C+JoAnn+M%3BMaldarelli%2C+Frank&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-15&rft.volume=47&rft.issue=12&rft.spage=e97&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F593314 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharm Pharmacol. 2003 Mar;55(3):381-6 [12724045] Clin Exp Immunol. 1976 Apr;24(1):54-62 [1084818] Clin Pharmacol Ther. 1986 Mar;39(3):313-7 [3948470] J Clin Pharmacol. 1994 Aug;34(8):854-8 [7962675] Clin Biochem. 2005 Jun;38(6):531-4 [15885232] AIDS Read. 2008 Feb;18(2):100-4 [18333287] J Clin Endocrinol Metab. 2005 Jul;90(7):4394-8 [15755851] J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):573-80 [16284534] Endocr Pract. 2005 Nov-Dec;11(6):408-10 [16638729] Ther Drug Monit. 2007 Dec;29(6):687-710 [18043468] Drug Metab Dispos. 2005 Jun;33(6):764-70 [15764714] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/593314 ER - TY - JOUR T1 - SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap AN - 20274009; 8920964 AB - Summary: The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies).Availability: SNAP server is available at http://www.broad.mit.edu/mpg/snap/.Contact: debakkerroad.mit.edu JF - Bioinformatics AU - Johnson, Andrew D AU - Handsaker, Robert E AU - Pulit, Sara L AU - Nizzari, Marcia M AU - O'Donnell, Christopher J AU - de Bakker, Paul IW AD - 1 The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health and Boston University School of Medicine, Framingham, MA 01702, 2 Broad Institute of MIT and Harvard, Cambridge, MA 02142, 3 Division of Genetics, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School-Partners HealthCare Center for Genetics and Genomics, 77 Avenue Louis Pasteur, Boston, MA 02215 and 4 Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 2938 EP - 2939 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 24 IS - 24 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Linkage disequilibrium KW - Data processing KW - Single-nucleotide polymorphism KW - Computer graphics KW - Bioinformatics KW - genomics KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20274009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SNAP%3A+a+web-based+tool+for+identification+and+annotation+of+proxy+SNPs+using+HapMap&rft.au=Johnson%2C+Andrew+D%3BHandsaker%2C+Robert+E%3BPulit%2C+Sara+L%3BNizzari%2C+Marcia+M%3BO%27Donnell%2C+Christopher+J%3Bde+Bakker%2C+Paul+IW&rft.aulast=Johnson&rft.aufirst=Andrew&rft.date=2008-12-15&rft.volume=24&rft.issue=24&rft.spage=2938&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn564 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Linkage disequilibrium; Data processing; Single-nucleotide polymorphism; Computer graphics; genomics; Bioinformatics DO - http://dx.doi.org/10.1093/bioinformatics/btn564 ER - TY - JOUR T1 - Polychlorinated dibenzo-p-dioxins/dibenzofuran mass distribution in both start-up and normal condition in the whole municipal solid waste incinerator AN - 19682334; 8615697 AB - Although many researches focused on the polychlorinated dibenzo-p-dioxins/dibenzofuran (PCDD/F) emissions from stack, in the bottom ash and in the surrounding environment, researches focused on PCDD/F mass distributions in the whole incineration plant have seldom been addressed. This study determined PCDD/F emissions in the whole plant. A high-resolution gas chromatograph /high-resolution mass spectrometer was utilized for analyzing 17 PCDD/F species. Experimental results displayed that PCDD/Fs were formed during fly ash from super heater (SH), economizer (EC), semi-dryer absorber (SDA) and fabric filter (FF) was transferred to fly ash pit. Mass distribution ratios of PCDD/Fs in g I-TEQ (Toxicity Equivalency Quantity) per week from stack, SH, EC, SDA, FF, generation and bottom residue (BR) in start-up operations were 14.6%, 0.1%, 8.3%, 1.0%, 41.7%, 33.4% and 0.9%, respectively. Above results indicated that main PCDD/F source in the MSWI was from fly ash. However, the fly ash is easily controlled and PCDD/F emitted from stack flue gases will be difficult to be handled. Therefore, we should pay more attention on PCDD/F emission from flue gases especially from start-up procedure. Besides, fly ash should be controlled by sodium hypophosphite before being landfilled. MSWI did require further detoxification treatments for the solid residues and flue gases. JF - Journal of Hazardous Materials AU - Chen, C K AU - Lin, C AU - Lin, Y C AU - Wang, L C AU - Chang-Chien, G P AD - National Pingtung University of Science and Technology, Nei Pu, Ping Tung 91207, Taiwan, linchieh@mail.npust.edu.tw Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 37 EP - 44 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 160 IS - 1 SN - 0304-3894, 0304-3894 KW - Pollution Abstracts; Toxicology Abstracts KW - Detoxification KW - Municipal solid wastes KW - Solid wastes KW - Incineration plants KW - Emissions KW - PCDD KW - Residues KW - Flue gas KW - Fly ash KW - Toxicity KW - Sodium KW - Filters KW - Fabrics KW - Gases KW - Dibenzofuran KW - Dibenzo-p-dioxin KW - Incinerators KW - P 0000:AIR POLLUTION KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19682334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Polychlorinated+dibenzo-p-dioxins%2Fdibenzofuran+mass+distribution+in+both+start-up+and+normal+condition+in+the+whole+municipal+solid+waste+incinerator&rft.au=Chen%2C+C+K%3BLin%2C+C%3BLin%2C+Y+C%3BWang%2C+L+C%3BChang-Chien%2C+G+P&rft.aulast=Chen&rft.aufirst=C&rft.date=2008-12-15&rft.volume=160&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2008.02.077 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fabrics; Filters; Detoxification; Sodium; Gases; Dibenzofuran; Dibenzo-p-dioxin; Incinerators; Fly ash; Toxicity; Solid wastes; Residues; Flue gas; Municipal solid wastes; Incineration plants; Emissions; PCDD DO - http://dx.doi.org/10.1016/j.jhazmat.2008.02.077 ER - TY - CPAPER T1 - Carbon Monoxide Blocks Lipopolysaccharide (LPS)-induced Gene Expression by Interfering with Proximal NF-B Signal Transduction in Human Monocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41913030; 5090089 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chhikara, M AU - Wang, S AU - Kern, S AU - Danner, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Carbon monoxide KW - Signal transduction KW - Gene expression KW - NF-B protein KW - Monocytes KW - Lipopolysaccharides KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Carbon+Monoxide+Blocks+Lipopolysaccharide+%28LPS%29-induced+Gene+Expression+by+Interfering+with+Proximal+NF-B+Signal+Transduction+in+Human+Monocytes.&rft.au=Chhikara%2C+M%3BWang%2C+S%3BKern%2C+S%3BDanner%2C+R&rft.aulast=Chhikara&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Receptor Possessing Chaperone Activity: The Sigma-1 Receptor at the Mitochondrion-associated ER Membrane. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41911458; 5090329 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Hayashi, T AU - Su, T. Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membranes KW - Chaperones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Receptor+Possessing+Chaperone+Activity%3A+The+Sigma-1+Receptor+at+the+Mitochondrion-associated+ER+Membrane.&rft.au=Hayashi%2C+T%3BSu%2C+T.&rft.aulast=Hayashi&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Metabolism and Signaling in Mouse Embryonic Fibroblasts Derived from an O-GlcNAcase (OGA) Knockout. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41910275; 5090590 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Keembiyehetty, C AU - Comly, M AU - Love, D AU - Robinson, G AU - Hennighausen, L AU - Hanover, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Metabolism KW - Signal transduction KW - Embryo fibroblasts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41910275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Altered+Metabolism+and+Signaling+in+Mouse+Embryonic+Fibroblasts+Derived+from+an+O-GlcNAcase+%28OGA%29+Knockout.&rft.au=Keembiyehetty%2C+C%3BComly%2C+M%3BLove%2C+D%3BRobinson%2C+G%3BHennighausen%2C+L%3BHanover%2C+J&rft.aulast=Keembiyehetty&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drosophila Myosin 7a Is Regulated by Intramolecular Folding. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41907049; 5090878 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Yang, Y AU - Baboolal, T AU - Siththanandan, V AU - Knight, P AU - Peckham, M AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41907049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Drosophila+Myosin+7a+Is+Regulated+by+Intramolecular+Folding.&rft.au=Yang%2C+Y%3BBaboolal%2C+T%3BSiththanandan%2C+V%3BKnight%2C+P%3BPeckham%2C+M%3BSellers%2C+J&rft.aulast=Yang&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of Cadherin 23 Alternate Transcripts and Protein Isoforms in the Mouse and Primate Inner Ear and Retina. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41902761; 5088757 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lagziel, A AU - Overlack, N AU - Wolfrum, U AU - Bernstein, S AU - Morell, R AU - Friedman, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Primates KW - Retina KW - Cadherin 23 KW - Inner ear KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Expression+of+Cadherin+23+Alternate+Transcripts+and+Protein+Isoforms+in+the+Mouse+and+Primate+Inner+Ear+and+Retina.&rft.au=Lagziel%2C+A%3BOverlack%2C+N%3BWolfrum%2C+U%3BBernstein%2C+S%3BMorell%2C+R%3BFriedman%2C+T&rft.aulast=Lagziel&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - One-Dimensional Topography Underlies Rapid Three-Dimensional Cell Migration. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41900455; 5090433 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Doyle, A AU - Wang, F AU - Matsumoto, K AU - Yamada, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Topography KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=One-Dimensional+Topography+Underlies+Rapid+Three-Dimensional+Cell+Migration.&rft.au=Doyle%2C+A%3BWang%2C+F%3BMatsumoto%2C+K%3BYamada%2C+K&rft.aulast=Doyle&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Is Tubulin Glutamylation Good For? An Analysis of Glutamylase Function in C. elegans. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41900281; 5090401 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Peel, N AU - O'Connell, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Tubulin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=What+Is+Tubulin+Glutamylation+Good+For%3F+An+Analysis+of+Glutamylase+Function+in+C.+elegans.&rft.au=Peel%2C+N%3BO%27Connell%2C+K&rft.aulast=Peel&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Hepatocyte Growth Factor Antagonist Engineered by Site-directed Mutagenesis of HGF/NK1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41899411; 5089086 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Cecchi, F AU - Pajalunga, D AU - Fowler, C AU - Peruzzi, B AU - MacDonald, N AU - Grella, D AU - Wingfield, P AU - Stahl, S AU - Kaufman, J AU - Byrd, A AU - Bottaro, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Growth factors KW - Hepatocyte growth factor KW - Site-directed mutagenesis KW - Mutagenesis KW - Hepatocytes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Hepatocyte+Growth+Factor+Antagonist+Engineered+by+Site-directed+Mutagenesis+of+HGF%2FNK1.&rft.au=Cecchi%2C+F%3BPajalunga%2C+D%3BFowler%2C+C%3BPeruzzi%2C+B%3BMacDonald%2C+N%3BGrella%2C+D%3BWingfield%2C+P%3BStahl%2C+S%3BKaufman%2C+J%3BByrd%2C+A%3BBottaro%2C+D&rft.aulast=Cecchi&rft.aufirst=Sreeparna&rft.date=2009-01-01&rft.volume=51&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health&rft.issn=13419145&rft_id=info:doi/10.1539%2Fjoh.L9070 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule Investigation of the Acto-Myosin-10 Complex Using Optical Tweezers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898945; 5088962 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Takagi, Y AU - Farrow, R AU - Mashanov, G AU - Batters, C AU - Yang, Y AU - Peckham, M AU - Sellers, J AU - Molloy, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Single+Molecule+Investigation+of+the+Acto-Myosin-10+Complex+Using+Optical+Tweezers.&rft.au=Takagi%2C+Y%3BFarrow%2C+R%3BMashanov%2C+G%3BBatters%2C+C%3BYang%2C+Y%3BPeckham%2C+M%3BSellers%2C+J%3BMolloy%2C+J&rft.aulast=Takagi&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin-X Is Required for Proper Behavior of Neural Crest Cells in Xenopus laevis T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898903; 5088961 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Hwang, Y AU - Luo, T AU - Xu, Y. AU - Sargent, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Neural crest KW - Amphibiotic species KW - Xenopus laevis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin-X+Is+Required+for+Proper+Behavior+of+Neural+Crest+Cells+in+Xenopus+laevis&rft.au=Hwang%2C+Y%3BLuo%2C+T%3BXu%2C+Y.%3BSargent%2C+T&rft.aulast=Hwang&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynein Light Chain LC8 Regulates Syntaphilin-mediated Docking of Axonal Mitochondria. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898063; 5091065 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chen, Y AU - Gerwin, C AU - Kang, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynein KW - Mitochondria KW - Light chains KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynein+Light+Chain+LC8+Regulates+Syntaphilin-mediated+Docking+of+Axonal+Mitochondria.&rft.au=Chen%2C+Y%3BGerwin%2C+C%3BKang%2C+J%3BSheng%2C+Z&rft.aulast=Chen&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CDC14 Dysfunction Leads to DNA Under-replication That Is Not Detected by Checkpoints. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41897355; 5089821 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Dulev, S AU - de Renty, C. AU - Schwob, E AU - Strunnikov, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - DNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=CDC14+Dysfunction+Leads+to+DNA+Under-replication+That+Is+Not+Detected+by+Checkpoints.&rft.au=Dulev%2C+S%3Bde+Renty%2C+C.%3BSchwob%2C+E%3BStrunnikov%2C+A&rft.aulast=Dulev&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Versatile Roles of a Splicegenerated C-terminal Extension of hCenexin1 in Polo-like Kinase 1 (Plk1)-dependent Mitotic Functions and Plk1-independent Ninein Recruitment and Ciliogenesis T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41890126; 5089033 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Soung, N AU - Yu, L. AU - Park, J AU - Lee, K AU - Lee, J AU - Veenstra, T AU - Rhee, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Recruitment KW - Polo-like kinase 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41890126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Versatile+Roles+of+a+Splicegenerated+C-terminal+Extension+of+hCenexin1+in+Polo-like+Kinase+1+%28Plk1%29-dependent+Mitotic+Functions+and+Plk1-independent+Ninein+Recruitment+and+Ciliogenesis&rft.au=Soung%2C+N%3BYu%2C+L.%3BPark%2C+J%3BLee%2C+K%3BLee%2C+J%3BVeenstra%2C+T%3BRhee%2C+K&rft.aulast=Soung&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane Fission: Lessons from Lipid Nanotubes and Dynamin. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41888706; 5088660 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Bashkirov, P AU - Sergey, A AU - Schmid, S AU - Zimmerberg, J AU - Frolov, V Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lipids KW - Nanotechnology KW - Membranes KW - Dynamin KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Membrane+Fission%3A+Lessons+from+Lipid+Nanotubes+and+Dynamin.&rft.au=Bashkirov%2C+P%3BSergey%2C+A%3BSchmid%2C+S%3BZimmerberg%2C+J%3BFrolov%2C+V&rft.aulast=Bashkirov&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell Biology in the Genomic Era T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41888614; 5088631 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Collins, Francis Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomics KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cell+Biology+in+the+Genomic+Era&rft.au=Collins%2C+Francis&rft.aulast=Collins&rft.aufirst=Francis&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epigenetic Genome Control by RNAi and Transposon-derived Proteins T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41883291; 5089401 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Grewal, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomes KW - RNA-mediated interference KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41883291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Epigenetic+Genome+Control+by+RNAi+and+Transposon-derived+Proteins&rft.au=Grewal%2C+S&rft.aulast=Grewal&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The N-terminal Regions of the HPS1 and HPS4 Proteins Are Required to Form the Biogenesis of Lysosome-related Organelle Complex 3 (BLOC-3). T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41883076; 5089358 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Carmona, C AU - Bonifacino, J AU - Cadilla, C AU - Gahl, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Organelles KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41883076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+N-terminal+Regions+of+the+HPS1+and+HPS4+Proteins+Are+Required+to+Form+the+Biogenesis+of+Lysosome-related+Organelle+Complex+3+%28BLOC-3%29.&rft.au=Carmona%2C+C%3BBonifacino%2C+J%3BCadilla%2C+C%3BGahl%2C+W&rft.aulast=Carmona&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deletion of the G2 Checkpoint Pathway Downstream Mediator of BRCA1, Wee1, in the Mammary Gland Results in Miscoordination of the Cell Cycle and Extensive DNA Damage. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41877729; 5089058 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Vasilopoulos, A AU - Tominaga, Y AU - Wang, R AU - Deng, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Downstream KW - Mammary gland KW - Cell cycle KW - DNA damage KW - BRCA1 protein KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Deletion+of+the+G2+Checkpoint+Pathway+Downstream+Mediator+of+BRCA1%2C+Wee1%2C+in+the+Mammary+Gland+Results+in+Miscoordination+of+the+Cell+Cycle+and+Extensive+DNA+Damage.&rft.au=Vasilopoulos%2C+A%3BTominaga%2C+Y%3BWang%2C+R%3BDeng%2C+C&rft.aulast=Vasilopoulos&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Traction Stress Variation across Single Focal Adhesions T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41877087; 5088792 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Plotnikov, S AU - Sabass, B AU - Schwarz, U AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Stress KW - Adhesion KW - Traction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Analysis+of+Traction+Stress+Variation+across+Single+Focal+Adhesions&rft.au=Plotnikov%2C+S%3BSabass%2C+B%3BSchwarz%2C+U%3BWaterman%2C+C&rft.aulast=Plotnikov&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of the Endocytic Pathway of ITIM-bearing Inhibitory Receptors: CD94/ NKG2A and LAIR-1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41874289; 5089539 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Peruzzi, G AU - Masilamani, M AU - Narayanan, S AU - Borrego, F AU - Coligan, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41874289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Study+of+the+Endocytic+Pathway+of+ITIM-bearing+Inhibitory+Receptors%3A+CD94%2F+NKG2A+and+LAIR-1.&rft.au=Peruzzi%2C+G%3BMasilamani%2C+M%3BNarayanan%2C+S%3BBorrego%2C+F%3BColigan%2C+J&rft.aulast=Peruzzi&rft.aufirst=G&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Condensin Is Essential for Centromeric Chromatin Assembly and Sister Kinetochore Orientation in Anaphase. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41870232; 5091329 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Samoshkin, A AU - Arnaoutov, A AU - Jansen, L AU - Ouispenski, I AU - Dye, L AU - Karpova, T AU - McNally, J AU - Dasso, M AU - Cleveland, D AU - Strunnikov, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetochores KW - Anaphase KW - Condensin KW - Chromatin remodeling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41870232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Condensin+Is+Essential+for+Centromeric+Chromatin+Assembly+and+Sister+Kinetochore+Orientation+in+Anaphase.&rft.au=Samoshkin%2C+A%3BArnaoutov%2C+A%3BJansen%2C+L%3BOuispenski%2C+I%3BDye%2C+L%3BKarpova%2C+T%3BMcNally%2C+J%3BDasso%2C+M%3BCleveland%2C+D%3BStrunnikov%2C+A&rft.aulast=Samoshkin&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - R-Spondin2/Int7 and Wnt-1 Stimulate Invasiveness and Tumorigenicity of Mammary Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41869222; 5090065 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Klauzinska, M AU - Raafat, A AU - Strizzi, L AU - Baljinnyam, B AU - Endo, Y AU - Rubin, J AU - Callahan, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Invasiveness KW - Epithelial cells KW - Mammary gland KW - Tumorigenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41869222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=R-Spondin2%2FInt7+and+Wnt-1+Stimulate+Invasiveness+and+Tumorigenicity+of+Mammary+Epithelial+Cells.&rft.au=Klauzinska%2C+M%3BRaafat%2C+A%3BStrizzi%2C+L%3BBaljinnyam%2C+B%3BEndo%2C+Y%3BRubin%2C+J%3BCallahan%2C+R&rft.aulast=Klauzinska&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein-free Liposomes Rescue Nuclear Envelope Formation by Fusion with Membrane Vesicles. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41868823; 5090704 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Rafikova, E AU - Melikov, K AU - Ramos, C AU - Dye, L AU - Chernomordik, L Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Nuclear membranes KW - Membrane vesicles KW - Membrane fusion KW - Liposomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Multiecho+dixon+fat+and+water+separation+method+for+detecting+fibrofatty+infiltration+in+the+myocardium&rft.au=Kellman%2C+Peter%3BHernando%2C+Diego%3BShah%2C+Saurabh%3BZuehlsdorff%2C+Sven%3BJerecic%2C+Renate%3BMancini%2C+Christine%3BLiang%2C+Zhi-Pei%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21657 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Position of Human Chromosomes Is Conserved in Mouse Nuclei Indicating a Species-independent Mechanism for Maintaining Genome Organization. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41867212; 5090152 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Sengupta, K AU - Camps, J AU - Mathews, P AU - Barenboim-Stapleton, L AU - Nguyen, Q AU - Difi lippantonio, M AU - Ried, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Chromosomes KW - Genomes KW - Nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Position+of+Human+Chromosomes+Is+Conserved+in+Mouse+Nuclei+Indicating+a+Species-independent+Mechanism+for+Maintaining+Genome+Organization.&rft.au=Sengupta%2C+K%3BCamps%2C+J%3BMathews%2C+P%3BBarenboim-Stapleton%2C+L%3BNguyen%2C+Q%3BDifi+lippantonio%2C+M%3BRied%2C+T&rft.aulast=Sengupta&rft.aufirst=K&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Th e Structure of Dynamin Family Members. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41866766; 5090129 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Mears, J AU - Fang, S AU - Ray, P AU - Heymann, J AU - Hinshaw, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41866766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Th+e+Structure+of+Dynamin+Family+Members.&rft.au=Mears%2C+J%3BFang%2C+S%3BRay%2C+P%3BHeymann%2C+J%3BHinshaw%2C+J&rft.aulast=Mears&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Varied Functions of Small, Non-coding RNAs in Bacteria. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41865673; 5090868 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Storz, G AU - Durand, S AU - Fontaine, F AU - Fozo, E AU - Opdyke, J AU - Waters, L AU - Zhang, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Non-coding RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41865673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Varied+Functions+of+Small%2C+Non-coding+RNAs+in+Bacteria.&rft.au=Storz%2C+G%3BDurand%2C+S%3BFontaine%2C+F%3BFozo%2C+E%3BOpdyke%2C+J%3BWaters%2C+L%3BZhang%2C+A&rft.aulast=Storz&rft.aufirst=G&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Medical+mycology&rft.issn=1460-2709&rft_id=info:doi/10.1080%2F13693780802056012 L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cleftin: A Novel Fibronectininduced Gene That Promotes Branching Morphogenesis. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864933; 5090239 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Onodera, T AU - Sakai, T AU - Yamada, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Morphogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cleftin%3A+A+Novel+Fibronectininduced+Gene+That+Promotes+Branching+Morphogenesis.&rft.au=Onodera%2C+T%3BSakai%2C+T%3BYamada%2C+K&rft.aulast=Onodera&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss-of-Function Mutations and Two-Furin Domain Derivatives Reveal Insights about R-spondin2 Structure and Activity. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864572; 5090575 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Li, S. AU - Yen, T AU - Endo, Y AU - Klauzinska, M AU - Baljinnyam, B AU - Macher, B AU - Callahan, R AU - Rubin, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mutation KW - Metabolites KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Loss-of-Function+Mutations+and+Two-Furin+Domain+Derivatives+Reveal+Insights+about+R-spondin2+Structure+and+Activity.&rft.au=Li%2C+S.%3BYen%2C+T%3BEndo%2C+Y%3BKlauzinska%2C+M%3BBaljinnyam%2C+B%3BMacher%2C+B%3BCallahan%2C+R%3BRubin%2C+J&rft.aulast=Li&rft.aufirst=S.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxysterol-binding Proteins Transfer Lipids at Organelle Contact Sites. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864195; 5090910 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Schulz, T AU - Choi, M AU - Mears, J AU - Hinshaw, J AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lipids KW - Organelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+reference+services+quarterly&rft.atitle=United+States+National+Library+of+Medicine+Drug+Information+Portal.&rft.au=Hochstein%2C+Colette%3BGoshorn%2C+Jeanne%3BChang%2C+Florence&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2009-01-01&rft.volume=28&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Medical+reference+services+quarterly&rft.issn=1540-9597&rft_id=info:doi/10.1080%2F02763860902816784 L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Synaptic Facilitation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41861609; 5090750 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kang, J AU - Pan, P AU - Tian, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mobility KW - Mitochondria KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Docking+of+Axonal+Mitochondria+by+Syntaphilin+Controls+Their+Mobility+and+Affects+Short-Term+Synaptic+Facilitation.&rft.au=Kang%2C+J%3BPan%2C+P%3BTian%2C+J%3BSheng%2C+Z&rft.aulast=Kang&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Throughput Screening, Probe Development, and the NIH Molecular Libraries Program T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41861099; 5088616 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Charya, Ananth AU - Colvis, Christine AU - Yao, Yong Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Probes KW - High-throughput screening KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=High-Throughput+Screening%2C+Probe+Development%2C+and+the+NIH+Molecular+Libraries+Program&rft.au=Charya%2C+Ananth%3BColvis%2C+Christine%3BYao%2C+Yong&rft.aulast=Charya&rft.aufirst=Ananth&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Is Essential for Focal Adhesion Assembly in Spreading Corneal Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860939; 5088783 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Pan, Q AU - Gao, C AU - Zelenka, P Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Epithelial cells KW - Cyclin-dependent kinase 5 KW - Cell migration KW - Cornea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Collection+and+preparation+of+rodent+tissue+samples+for+histopathological+and+molecular+studies+in+carcinogenesis.&rft.au=Golubeva%2C+Yelena%3BRogers%2C+Keith&rft.aulast=Golubeva&rft.aufirst=Yelena&rft.date=2009-01-01&rft.volume=511&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-447-6_1 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin II Activity Is Necessary for Growth Cone Turning at the Chondroitin Sulfate Proteoglycan Boundary. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860264; 5091188 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Santiago, L AU - Katagiri, Y AU - Geller, H Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Sulfate KW - Myosin KW - Growth cones KW - Chondroitin sulfate KW - Proteoglycans KW - Boundaries KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin+II+Activity+Is+Necessary+for+Growth+Cone+Turning+at+the+Chondroitin+Sulfate+Proteoglycan+Boundary.&rft.au=Santiago%2C+L%3BKatagiri%2C+Y%3BGeller%2C+H&rft.aulast=Santiago&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stable and Prolonged Contacts Form between Cilia of Adjacent Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860216; 5091183 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ott, C AU - Sengupta, P AU - Elia, N AU - Case, L AU - Lippincott- Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cilia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Stable+and+Prolonged+Contacts+Form+between+Cilia+of+Adjacent+Cells.&rft.au=Ott%2C+C%3BSengupta%2C+P%3BElia%2C+N%3BCase%2C+L%3BLippincott-+Schwartz%2C+J&rft.aulast=Ott&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modifications of Membrane Protein Diffusion in P. falciparum-infected Erythrocytes Studied by Quantum Dot-based Multi-particle Tracking. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860135; 5091374 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Tokumasu, F AU - Clarke, M AU - Crivat, G AU - Ostera, G AU - Hwang, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membrane proteins KW - Erythrocytes KW - Diffusion KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Modifications+of+Membrane+Protein+Diffusion+in+P.+falciparum-infected+Erythrocytes+Studied+by+Quantum+Dot-based+Multi-particle+Tracking.&rft.au=Tokumasu%2C+F%3BClarke%2C+M%3BCrivat%2C+G%3BOstera%2C+G%3BHwang%2C+J&rft.aulast=Tokumasu&rft.aufirst=F&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role of Snapin in Coordinating Late Endocytic Trafficking and Autophagy-Lysosomal Function T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859938; 5088715 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Cai, Q AU - Lu, L. AU - Tian, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Essential+Role+of+Snapin+in+Coordinating+Late+Endocytic+Trafficking+and+Autophagy-Lysosomal+Function&rft.au=Cai%2C+Q%3BLu%2C+L.%3BTian%2C+J%3BSheng%2C+Z&rft.aulast=Cai&rft.aufirst=Q&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biased Gliding of Magnetized Actin Cytoskeleton in Applied Magnetic Field. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859586; 5091267 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chen, Y AU - Conroy, R AU - Sumner, J AU - Moreland, J AU - Koretsky, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cytoskeleton KW - Actin KW - Magnetic fields KW - Gliding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Biased+Gliding+of+Magnetized+Actin+Cytoskeleton+in+Applied+Magnetic+Field.&rft.au=Chen%2C+Y%3BConroy%2C+R%3BSumner%2C+J%3BMoreland%2C+J%3BKoretsky%2C+A&rft.aulast=Chen&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Th e Spatial Organization of Genomes T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859575; 5088640 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Misteli, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Th+e+Spatial+Organization+of+Genomes&rft.au=Misteli%2C+T&rft.aulast=Misteli&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin II Mediates Local Cortical Tension to Guide Endothelial Cell Branching Morphogenesis and Migration in 3D. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859166; 5090424 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Fischer, R AU - Gardel, M AU - Ma, X. AU - Adelstein, R AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Myosin KW - Cell migration KW - Endothelial cells KW - Cortex KW - Morphogenesis KW - Tension KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin+II+Mediates+Local+Cortical+Tension+to+Guide+Endothelial+Cell+Branching+Morphogenesis+and+Migration+in+3D.&rft.au=Fischer%2C+R%3BGardel%2C+M%3BMa%2C+X.%3BAdelstein%2C+R%3BWaterman%2C+C&rft.aulast=Fischer&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bridging Engineering and Life Sciences: Next Generation Tools for Cell Biology T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858941; 5088612 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lee, Jerry Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Bridging+Engineering+and+Life+Sciences%3A+Next+Generation+Tools+for+Cell+Biology&rft.au=Lee%2C+Jerry&rft.aulast=Lee&rft.aufirst=Jerry&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of PolD3 Accessory Subunit in AID-mediated Mutagenesis and Recombination. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858873; 5091548 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Poltoratsky, V AU - Horton, J AU - Wilson, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mutagenesis KW - Recombination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+PolD3+Accessory+Subunit+in+AID-mediated+Mutagenesis+and+Recombination.&rft.au=Poltoratsky%2C+V%3BHorton%2C+J%3BWilson%2C+S&rft.aulast=Poltoratsky&rft.aufirst=V&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Localized Production of RanGTP at the Chromatin-Cytoplasm Interface Is Sufficient and Required for Bipolar Mitotic Spindle Assembly in Xenopus laevis Egg Extracts. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858092; 5090519 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kalab, P AU - Halpin, D AU - Heald, R AU - Weis, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Spindles KW - Amphibiotic species KW - Xenopus laevis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Localized+Production+of+RanGTP+at+the+Chromatin-Cytoplasm+Interface+Is+Sufficient+and+Required+for+Bipolar+Mitotic+Spindle+Assembly+in+Xenopus+laevis+Egg+Extracts.&rft.au=Kalab%2C+P%3BHalpin%2C+D%3BHeald%2C+R%3BWeis%2C+K&rft.aulast=Kalab&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myofibril Assembly Visualized by Imaging N-RAP, Alpha-Actinin, and Actin in Living Cardiomyocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857816; 5089671 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Manisastry, S AU - Zaal, K AU - Horowits, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cardiomyocytes KW - Actin KW - Imaging techniques KW - Myofibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myofibril+Assembly+Visualized+by+Imaging+N-RAP%2C+Alpha-Actinin%2C+and+Actin+in+Living+Cardiomyocytes.&rft.au=Manisastry%2C+S%3BZaal%2C+K%3BHorowits%2C+R&rft.aulast=Manisastry&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetic Characterization of the Myosin IIA with an N-terminal GFP Fused Regulatory Light Chain. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857786; 5090427 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kengyel, A AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetics KW - Myosin KW - Light chains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Kinetic+Characterization+of+the+Myosin+IIA+with+an+N-terminal+GFP+Fused+Regulatory+Light+Chain.&rft.au=Kengyel%2C+A%3BSellers%2C+J&rft.aulast=Kengyel&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PIPs Modulate the Sterol Affinity of Oxysterol Binding Proteins at Membrane Contact Sites. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857724; 5088858 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Schulz, T AU - Chung, R AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membranes KW - Sterols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=PIPs+Modulate+the+Sterol+Affinity+of+Oxysterol+Binding+Proteins+at+Membrane+Contact+Sites.&rft.au=Schulz%2C+T%3BChung%2C+R%3BPrinz%2C+W&rft.aulast=Schulz&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomics Analysis of Focal Adhesion Maturation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857468; 5088794 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kuo, J AU - Han, X AU - Yates, J AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Proteomics KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Proteomics+Analysis+of+Focal+Adhesion+Maturation.&rft.au=Kuo%2C+J%3BHan%2C+X%3BYates%2C+J%3BWaterman%2C+C&rft.aulast=Kuo&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Del-1 (Developmental Endothelial Locus-1) Is an Endogenous Inhibitor of Leukocyte-Endothelial Adhesion Limiting Inflammatory Cell Recruitment. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857383; 5090979 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Choi, E AU - Chavakis, E AU - Czabanka, M AU - Langer, H AU - Fraemohs, L AU - Economopoulou, M AU - Kundu, R AU - Gahmberg, C AU - Udey, M AU - Vajkoczy, P AU - Quertermous, T AU - Dimmeler, S AU - Weber, C AU - Chavakis, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Recruitment KW - Inflammation KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Del-1+%28Developmental+Endothelial+Locus-1%29+Is+an+Endogenous+Inhibitor+of+Leukocyte-Endothelial+Adhesion+Limiting+Inflammatory+Cell+Recruitment.&rft.au=Choi%2C+E%3BChavakis%2C+E%3BCzabanka%2C+M%3BLanger%2C+H%3BFraemohs%2C+L%3BEconomopoulou%2C+M%3BKundu%2C+R%3BGahmberg%2C+C%3BUdey%2C+M%3BVajkoczy%2C+P%3BQuertermous%2C+T%3BDimmeler%2C+S%3BWeber%2C+C%3BChavakis%2C+T&rft.aulast=Choi&rft.aufirst=E&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Microtubule Plus End- Binding Protein EB1 Is Necessary for Muscle Cell Differentiation, Elongation, and Fusion. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857070; 5088910 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Zhang, T AU - Zaal, K AU - Reid, E AU - Sheridan, J AU - Mehta, A AU - Gundersen, G AU - Ralston, E Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Muscles KW - Cell differentiation KW - Differentiation KW - Microtubules KW - Elongation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Microtubule+Plus+End-+Binding+Protein+EB1+Is+Necessary+for+Muscle+Cell+Differentiation%2C+Elongation%2C+and+Fusion.&rft.au=Zhang%2C+T%3BZaal%2C+K%3BReid%2C+E%3BSheridan%2C+J%3BMehta%2C+A%3BGundersen%2C+G%3BRalston%2C+E&rft.aulast=Zhang&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nup107-160 Complex and - TuRC Regulate Microtubule Polymerization at Kinetochores. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41855275; 5089796 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Mishra, R AU - Chakraborty, P AU - Arnaoutov, A AU - Fontoura, B AU - Dasso, M Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetochores KW - Microtubules KW - Polymerization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Nup107-160+Complex+and+-+TuRC+Regulate+Microtubule+Polymerization+at+Kinetochores.&rft.au=Mishra%2C+R%3BChakraborty%2C+P%3BArnaoutov%2C+A%3BFontoura%2C+B%3BDasso%2C+M&rft.aulast=Mishra&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of TRPC1-Interacting Proteins by Tandem Mass Spectroscopy. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854988; 5090308 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lockwich, T AU - Makusky, A AU - Kowalak, J AU - Markey, S AU - Ambudkar, I Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mass spectroscopy KW - Trp protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Analysis+of+TRPC1-Interacting+Proteins+by+Tandem+Mass+Spectroscopy.&rft.au=Lockwich%2C+T%3BMakusky%2C+A%3BKowalak%2C+J%3BMarkey%2C+S%3BAmbudkar%2C+I&rft.aulast=Lockwich&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LRRK2 Regulates Neurite Outgrowth via Modulation of ERM Phosphorylation and Actin Remodeling. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854950; 5091589 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Parisiadou, L AU - Xie, C AU - Wang, L AU - Gu, X. AU - Lin, X AU - Shim, H AU - Li, Z. AU - Cai, H Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - LRRK2 protein KW - Actin KW - Phosphorylation KW - Axonogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=LRRK2+Regulates+Neurite+Outgrowth+via+Modulation+of+ERM+Phosphorylation+and+Actin+Remodeling.&rft.au=Parisiadou%2C+L%3BXie%2C+C%3BWang%2C+L%3BGu%2C+X.%3BLin%2C+X%3BShim%2C+H%3BLi%2C+Z.%3BCai%2C+H&rft.aulast=Parisiadou&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the Penta-EF-Hand Protein ALG-2 as a Ca2+-dependent Interactor of Mucolipin-1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854888; 5089447 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Vergarajauregui, S AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Calcium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Identification+of+the+Penta-EF-Hand+Protein+ALG-2+as+a+Ca2%2B-dependent+Interactor+of+Mucolipin-1.&rft.au=Vergarajauregui%2C+S%3BPuertollano%2C+R&rft.aulast=Vergarajauregui&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Reticulons and DP1/ Yop1p in Maintaining ER Tubules. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854681; 5090207 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Voss, C AU - Shibata, Y AU - Rapoport, T AU - Voeltz, G AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Tubules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+Reticulons+and+DP1%2F+Yop1p+in+Maintaining+ER+Tubules.&rft.au=Voss%2C+C%3BShibata%2C+Y%3BRapoport%2C+T%3BVoeltz%2C+G%3BPrinz%2C+W&rft.aulast=Voss&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule Kinetic Measurements of Non-Muscle Myosin IIB Using Optical Tweezers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854641; 5090428 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Nagy, A AU - Takagi, Y AU - Kovacs, M AU - Homsher, E AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetics KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Single+Molecule+Kinetic+Measurements+of+Non-Muscle+Myosin+IIB+Using+Optical+Tweezers.&rft.au=Nagy%2C+A%3BTakagi%2C+Y%3BKovacs%2C+M%3BHomsher%2C+E%3BSellers%2C+J&rft.aulast=Nagy&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Uptake and Trafficking of Fluorescently Conjugated Dextran and Transferrin: A Comparison of Salivary Gland Fibroblasts in Live Rodents and Isolated Fibroblasts in Culture. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854206; 5090353 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Masedunskas, A AU - Weigert, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Rodents KW - Fibroblasts KW - Transferrin KW - Salivary gland KW - Dextran KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Uptake+and+Trafficking+of+Fluorescently+Conjugated+Dextran+and+Transferrin%3A+A+Comparison+of+Salivary+Gland+Fibroblasts+in+Live+Rodents+and+Isolated+Fibroblasts+in+Culture.&rft.au=Masedunskas%2C+A%3BWeigert%2C+R&rft.aulast=Masedunskas&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Snapin Plays a Key Role as an Adaptor for CPE Cytoplasmic Tail to Connect Hormone Vesicles to Microtubule Motor Complex. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853678; 5089584 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Park, J AU - Loh, Y Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Hormones KW - Microtubules KW - Vesicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Snapin+Plays+a+Key+Role+as+an+Adaptor+for+CPE+Cytoplasmic+Tail+to+Connect+Hormone+Vesicles+to+Microtubule+Motor+Complex.&rft.au=Park%2C+J%3BLoh%2C+Y&rft.aulast=Park&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MCOLN3 Is Involved in the Trafficking of Cargo Proteins along the Endo/ lysosomal Compartment in the Retinal Pigment Epithelial Cell Line ARPE-19. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853647; 5089446 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Martina, J AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Pigments KW - Retinal pigment epithelium KW - Retina KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=MCOLN3+Is+Involved+in+the+Trafficking+of+Cargo+Proteins+along+the+Endo%2F+lysosomal+Compartment+in+the+Retinal+Pigment+Epithelial+Cell+Line+ARPE-19.&rft.au=Martina%2C+J%3BPuertollano%2C+R&rft.aulast=Martina&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sorting Nexin 27: A Novel Regulator of CFTR Trafficking. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853598; 5089443 JF - 48th Annual Meeting of the American Society for Cell Biology AU - McDermott, M AU - Thelin, W AU - Lyons, P AU - Gentzsch, M AU - Hong, W AU - Stutts, M AU - Milgram, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Nexin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Sorting+Nexin+27%3A+A+Novel+Regulator+of+CFTR+Trafficking.&rft.au=McDermott%2C+M%3BThelin%2C+W%3BLyons%2C+P%3BGentzsch%2C+M%3BHong%2C+W%3BStutts%2C+M%3BMilgram%2C+S&rft.aulast=McDermott&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Angiotensin IIInduced ERK1/2 Activation in Primary Fetal Cardiomyocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853355; 5089877 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Yin, X AU - Zhang, M AU - Hu, L. AU - Catt, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cardiomyocytes KW - Angiotensin KW - Fetuses KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Mechanism+of+Angiotensin+IIInduced+ERK1%2F2+Activation+in+Primary+Fetal+Cardiomyocytes.&rft.au=Yin%2C+X%3BZhang%2C+M%3BHu%2C+L.%3BCatt%2C+K&rft.aulast=Yin&rft.aufirst=X&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin Regulates Apical Constriction in Epithelial Monolayers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853253; 5089599 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chua, J AU - Rikhy, R AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynamin KW - Monomolecular films KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynamin+Regulates+Apical+Constriction+in+Epithelial+Monolayers.&rft.au=Chua%2C+J%3BRikhy%2C+R%3BLippincott-Schwartz%2C+J&rft.aulast=Chua&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Targeting of Misfolded Proteins in the Endoplasmic Reticulum for Degradation by Autophagy. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851398; 5090942 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Satpute- Krishnan, P AU - Hegde, R AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Degradation KW - Protein folding KW - Endoplasmic reticulum KW - Phagocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Selective+Targeting+of+Misfolded+Proteins+in+the+Endoplasmic+Reticulum+for+Degradation+by+Autophagy.&rft.au=Satpute-+Krishnan%2C+P%3BHegde%2C+R%3BLippincott-Schwartz%2C+J&rft.aulast=Satpute-+Krishnan&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SIRT1 Inhibitor Alleviates FMR1 Gene Silencing in Fragile X Cell Lines T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851248; 5091415 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Biacsi, R AU - Kumari, D AU - Usdin, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Gene silencing KW - SIRT1 protein KW - Fragile X mental retardation protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=SIRT1+Inhibitor+Alleviates+FMR1+Gene+Silencing+in+Fragile+X+Cell+Lines&rft.au=Biacsi%2C+R%3BKumari%2C+D%3BUsdin%2C+K&rft.aulast=Biacsi&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Nef Mediates Ubiquitination-independent Targeting of CD4 to the MVB Pathway. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851107; 5090853 JF - 48th Annual Meeting of the American Society for Cell Biology AU - daSilva, L AU - Sougrat, R AU - Burgos, P AU - Janvier, K AU - Bonifacino, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Nef protein KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=HIV-1+Nef+Mediates+Ubiquitination-independent+Targeting+of+CD4+to+the+MVB+Pathway.&rft.au=daSilva%2C+L%3BSougrat%2C+R%3BBurgos%2C+P%3BJanvier%2C+K%3BBonifacino%2C+J&rft.aulast=daSilva&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Activity Regulates Cytoskeletal Organization by Controlling Rhodependent Myosin Phosphorylation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849910; 5091137 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Tripathi, B AU - Gao, C AU - Zelenka, P Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Cytoskeleton KW - Cyclin-dependent kinase 5 KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cdk5+Activity+Regulates+Cytoskeletal+Organization+by+Controlling+Rhodependent+Myosin+Phosphorylation.&rft.au=Tripathi%2C+B%3BGao%2C+C%3BZelenka%2C+P&rft.aulast=Tripathi&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topology Rather than Cell Lineage Determines the Presence of the Subcortical Maternal Complex in Preimplantation Mouse Development. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849882; 5090763 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Baibakov, B AU - Li, L. AU - Dean, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cell lineage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Topology+Rather+than+Cell+Lineage+Determines+the+Presence+of+the+Subcortical+Maternal+Complex+in+Preimplantation+Mouse+Development.&rft.au=Baibakov%2C+B%3BLi%2C+L.%3BDean%2C+J&rft.aulast=Baibakov&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Distribution of the Feminization Factor Homolog Fem1b in Human Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849564; 5090925 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lelouvier, B AU - Martina, J AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Epithelial cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Intracellular+Distribution+of+the+Feminization+Factor+Homolog+Fem1b+in+Human+Epithelial+Cells.&rft.au=Lelouvier%2C+B%3BMartina%2C+J%3BPuertollano%2C+R&rft.aulast=Lelouvier&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin Regulates Actin Cytoskeleton Remodeling for Metaphase Furrow Formation through Diaphanous in the Syncytial Drosophila Blastoderm. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41848536; 5091451 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Rikhy, R AU - Mavrakis, M AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Metaphase KW - Cytoskeleton KW - Blastoderm KW - Actin KW - Dynamin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynamin+Regulates+Actin+Cytoskeleton+Remodeling+for+Metaphase+Furrow+Formation+through+Diaphanous+in+the+Syncytial+Drosophila+Blastoderm.&rft.au=Rikhy%2C+R%3BMavrakis%2C+M%3BLippincott-Schwartz%2C+J&rft.aulast=Rikhy&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Sel1-domain Protein EnhC in Host Cell Entry by the Obligate Intracellular Bacterium Coxiella burnetii. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844921; 5089308 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Gilk, S AU - Cirillo, S AU - Cirillo, J AU - Heinzen, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Proteins KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+the+Sel1-domain+Protein+EnhC+in+Host+Cell+Entry+by+the+Obligate+Intracellular+Bacterium+Coxiella+burnetii.&rft.au=Gilk%2C+S%3BCirillo%2C+S%3BCirillo%2C+J%3BHeinzen%2C+R&rft.aulast=Gilk&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel E3 Ubiquitin Ligase LNXL Determines Dorso-Ventral Body Patterning by Negatively Regulating Bozozok Stability T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844900; 5089225 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ro, H. AU - Dawid, I Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Ubiquitin-protein ligase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Novel+E3+Ubiquitin+Ligase+LNXL+Determines+Dorso-Ventral+Body+Patterning+by+Negatively+Regulating+Bozozok+Stability&rft.au=Ro%2C+H.%3BDawid%2C+I&rft.aulast=Ro&rft.aufirst=H.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tubulin Binding to Mitochondrial Outer Membrane through Interaction of the C-terminal "Tails" with VDAC Regulates Respiration - Biophysics, Physiology, and Evolution. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844790; 5090398 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Sherm, J AU - Rostovtseva, T AU - Monge, C AU - Sheldon, K AU - Wolff, J AU - Saks, V AU - Bezrukov, S AU - Sackett, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Respiration KW - Outer membranes KW - Physiology KW - Biophysics KW - Mitochondria KW - Tubulin KW - Electron transport KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Tubulin+Binding+to+Mitochondrial+Outer+Membrane+through+Interaction+of+the+C-terminal+%22Tails%22+with+VDAC+Regulates+Respiration+-+Biophysics%2C+Physiology%2C+and+Evolution.&rft.au=Sherm%2C+J%3BRostovtseva%2C+T%3BMonge%2C+C%3BSheldon%2C+K%3BWolff%2C+J%3BSaks%2C+V%3BBezrukov%2C+S%3BSackett%2C+D&rft.aulast=Sherm&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Trafficking Routes for Cargo Proteins Entering Cells via Clathrinindependent Endocytosis. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844544; 5090354 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Eyster, C AU - Huebner, R AU - Higginson, J AU - Porat-Shliom, N AU - Weigert, R AU - Donaldson, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Endocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=New+Trafficking+Routes+for+Cargo+Proteins+Entering+Cells+via+Clathrinindependent+Endocytosis.&rft.au=Eyster%2C+C%3BHuebner%2C+R%3BHigginson%2C+J%3BPorat-Shliom%2C+N%3BWeigert%2C+R%3BDonaldson%2C+J&rft.aulast=Eyster&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SirT1 Represses MMP13 Expression in Human Articular Chondrocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844195; 5089455 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lee, E AU - Gagarina, V AU - Dvir-Ginzburg, M AU - Hall, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Collagenase 3 KW - Chondrocytes KW - SIRT1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=SirT1+Represses+MMP13+Expression+in+Human+Articular+Chondrocytes.&rft.au=Lee%2C+E%3BGagarina%2C+V%3BDvir-Ginzburg%2C+M%3BHall%2C+D&rft.aulast=Lee&rft.aufirst=E&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nonmuscle Myosin II-A Motor Domain Is Important for Early Mouse Embryonic Development. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844122; 5090426 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Wang, A AU - Ma, X. AU - Adelstein, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Embryogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Nonmuscle+Myosin+II-A+Motor+Domain+Is+Important+for+Early+Mouse+Embryonic+Development.&rft.au=Wang%2C+A%3BMa%2C+X.%3BAdelstein%2C+R&rft.aulast=Wang&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Effect of Ablation of Nonmuscle Myosin II-B and II-C on Karyokinesis in Mouse Cardiac Myocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844078; 5090425 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ma, X. AU - Kawamoto, S AU - Conti, M AU - Jana, S AU - Adelstein, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Synergistic effects KW - Cardiomyocytes KW - Myosin KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Synergistic+Effect+of+Ablation+of+Nonmuscle+Myosin+II-B+and+II-C+on+Karyokinesis+in+Mouse+Cardiac+Myocytes.&rft.au=Ma%2C+X.%3BKawamoto%2C+S%3BConti%2C+M%3BJana%2C+S%3BAdelstein%2C+R&rft.aulast=Ma&rft.aufirst=X.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of Anthrax Lethal Toxin: Impact of the N-Terminal Amino Acid. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41843124; 5089356 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Gupta, P AU - Moayeri, M AU - Leppla, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Anthrax lethal toxin KW - Amino acids KW - Toxins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Activity+of+Anthrax+Lethal+Toxin%3A+Impact+of+the+N-Terminal+Amino+Acid.&rft.au=Gupta%2C+P%3BMoayeri%2C+M%3BLeppla%2C+S&rft.aulast=Gupta&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of NHERF-1 in the Regulation of T Lymphocyte Adhesion and Migration. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41843022; 5089731 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ben Aissa, K AU - Liu, Y AU - Shomer, I AU - Hao, J AU - Steplock, D AU - Weinman, E AU - Shaw, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Adhesion KW - Lymphocytes KW - Leukocyte migration KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+NHERF-1+in+the+Regulation+of+T+Lymphocyte+Adhesion+and+Migration.&rft.au=Ben+Aissa%2C+K%3BLiu%2C+Y%3BShomer%2C+I%3BHao%2C+J%3BSteplock%2C+D%3BWeinman%2C+E%3BShaw%2C+S&rft.aulast=Ben+Aissa&rft.aufirst=K&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Queen's University T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41842923; 5089351 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Li, H. AU - Lee, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cancer KW - Genetics KW - Pathology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Pathology+and+Molecular+Medicine%2C+Division+of+Cancer+Biology+and+Genetics%2C+Queen%27s+University&rft.au=Li%2C+H.%3BLee%2C+S&rft.aulast=Li&rft.aufirst=H.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three Dimensional Superresolution Fluorescence Microscopy Reveals Protein Stratification in Focal Adhesions. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41842158; 5088793 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kanchanawong, P AU - Shtengel, G AU - Davidson, M AU - Hess, H AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Stratification KW - Fluorescence microscopy KW - Adhesion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Three+Dimensional+Superresolution+Fluorescence+Microscopy+Reveals+Protein+Stratification+in+Focal+Adhesions.&rft.au=Kanchanawong%2C+P%3BShtengel%2C+G%3BDavidson%2C+M%3BHess%2C+H%3BWaterman%2C+C&rft.aulast=Kanchanawong&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LOK is the Dominant ERM Kinase in Resting Lymphocytes and Regulates Cytoskeletal Rearrangement through ERM Phosphorylation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41838732; 5089616 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Belkina, N AU - Liu, Y AU - Hao, J AU - Shaw, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lymphocytes KW - Cytoskeleton KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=LOK+is+the+Dominant+ERM+Kinase+in+Resting+Lymphocytes+and+Regulates+Cytoskeletal+Rearrangement+through+ERM+Phosphorylation.&rft.au=Belkina%2C+N%3BLiu%2C+Y%3BHao%2C+J%3BShaw%2C+S&rft.aulast=Belkina&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determinants of the Specificity of Plk1 PBD Binding and Development of a Highly Sensitive Plk1 ELISA Assay. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41838133; 5089806 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Park, J AU - Moulaei, T AU - Lim, D AU - Kang, Y AU - Strebhardt, K AU - Yaffe, M AU - Wlodawer, A AU - Lee, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Polo-like kinase 1 KW - ELISA KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Determinants+of+the+Specificity+of+Plk1+PBD+Binding+and+Development+of+a+Highly+Sensitive+Plk1+ELISA+Assay.&rft.au=Park%2C+J%3BMoulaei%2C+T%3BLim%2C+D%3BKang%2C+Y%3BStrebhardt%2C+K%3BYaffe%2C+M%3BWlodawer%2C+A%3BLee%2C+K&rft.aulast=Park&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - UV radiation regulates Mi-2 through protein translation and stability. AN - 69866902; 18922793 AB - Dermatomyositis (DM) is an autoimmune disease, which is often accompanied by the development of disease-specific autoantibodies directed against the SNF2-superfamily helicase, Mi-2. Recent evidence suggests that ultraviolet radiation exposure may be an important risk factor for the development of not only the disease but also specific autoimmunity against Mi-2. Consequently, we investigated the effects of ultraviolet radiation on Mi-2 protein expression. We observed an increase in protein levels upon ultraviolet radiation exposure in cell culture systems. These changes in expression occur quite rapidly, are maximized just 1 h following exposure, and are unique to Mi-2 when compared with other members of the NuRD complex. Changes in protein levels are not mediated through transcriptional mechanisms. Treatment results in a more efficiently translated message through regulatory elements in the 5'-UTR region of the transcript. Investigation into protein half-life further demonstrated increased stability of Mi-2 following UV exposure. Taken together, we describe a system by which Mi-2 protein expression can be quickly increased following UV exposure and then maintained up to 16 h later. These data provide a novel regulation of an important transcriptional regulator and provide insight into the possible mechanisms of the development of DM and associated autoantibodies. JF - The Journal of biological chemistry AU - Burd, Craig J AU - Kinyamu, H Karimi AU - Miller, Frederick W AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Intitutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 34976 EP - 34982 VL - 283 IS - 50 SN - 0021-9258, 0021-9258 KW - 5' Untranslated Regions KW - 0 KW - Autoantibodies KW - Autoantigens KW - CHD4 protein, human KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - EC 3.5.1.98 KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Plasmids -- metabolism KW - Humans KW - Autoantibodies -- chemistry KW - Transcription, Genetic KW - Cell Line, Tumor KW - Cell Separation KW - Models, Biological KW - Risk Factors KW - Flow Cytometry KW - Keratinocytes -- metabolism KW - Time Factors KW - Ultraviolet Rays KW - DNA Helicases -- metabolism KW - Protein Biosynthesis -- radiation effects KW - Autoantigens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69866902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=UV+radiation+regulates+Mi-2+through+protein+translation+and+stability.&rft.au=Burd%2C+Craig+J%3BKinyamu%2C+H+Karimi%3BMiller%2C+Frederick+W%3BArcher%2C+Trevor+K&rft.aulast=Burd&rft.aufirst=Craig&rft.date=2008-12-12&rft.volume=283&rft.issue=50&rft.spage=34976&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M805383200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Dec 15;59(24):6087-90 [10626795] Nature. 1998 Oct 29;395(6705):917-21 [9804427] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9209-14 [10922072] Nature. 2002 Aug 29;418(6901):994-8 [12198550] Mol Cell. 2002 Dec;10(6):1441-52 [12504018] Rheumatology (Oxford). 2003 Jan;42(1):34-9 [12509610] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8354-9 [12821781] Arthritis Rheum. 2003 Aug;48(8):2285-93 [12905483] Semin Oncol. 2003 Oct;30(5 Suppl 16):30-7 [14613024] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):3-11 [15020040] Immunity. 2004 Jun;20(6):719-33 [15189737] Arthritis Rheum. 1985 Jul;28(7):796-803 [2409985] Am J Med. 1994 May;96(5):457-62 [8192178] J Rheumatol. 1998 Feb;25(2):395-6 [9489847] Mol Cell. 1998 Dec;2(6):851-61 [9885572] Immunity. 1999 Mar;10(3):345-55 [10204490] Mol Endocrinol. 2004 Dec;18(12):2937-49 [15358836] J Exp Med. 2005 Feb 21;201(4):591-601 [15728237] Curr Rheumatol Rep. 2005 Apr;7(2):99-105 [15760588] Autoimmunity. 2005 Feb;38(1):79-83 [15966133] Cell. 2005 Oct 7;123(1):49-63 [16213212] EMBO J. 2006 Sep 6;25(17):3986-97 [16932743] Clin Dermatol. 2006 Sep-Oct;24(5):363-73 [16966018] Curr Opin Rheumatol. 2006 Nov;18(6):620-4 [17053509] Joint Bone Spine. 2006 Dec;73(6):646-54 [17110150] J Biol Chem. 2007 May 11;282(19):13994-4005 [17344210] Oncogene. 2007 Aug 13;26(37):5433-8 [17694084] Mol Biol Cell. 2007 Sep;18(9):3667-80 [17626165] Mol Endocrinol. 2007 Dec;21(12):2907-18 [17761946] Nat Clin Pract Rheumatol. 2008 Apr;4(4):201-9 [18319710] Curr Biol. 1998 Jul 2;8(14):843-6 [9663395] Cell. 1998 Oct 16;95(2):279-89 [9790534] J Biol Chem. 2000 Jun 9;275(23):17771-7 [10748103] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M805383200 ER - TY - JOUR T1 - Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study AN - 20734936; 8934121 AB - Background Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric add concentration and gout. Methods Genome-wide association studies were done for serum uric add in 7699 participants in the Framingham cohort and in 4148 participants in the Rotterdam cohort. Genome-wide significant single nudeotide polymorphisms (SNPs) were replicated in white (n=11 024) and black (n=3843) individuals who took part in the study of Atherosderosis Risk in Communities (ARIC). The SNPs that readied genome-wide significant association with uric add in either the Framingham cohort (p<5 times 0x10 super(-8)) or the Rotterdam cohort (p<1 times 0x10 super(-7)) were evaluated with gout The results obtained in white participants were combined using meta-analysis. Findings Three loci in the Framingham cohort and two in the Rotterdam cohort showed genome-wide association with uric add. Top SNPs in each locus were: missense rs16890979 in SLC2A9 (p=7 times 0x10 super(-168) and 2 times 9x10 super(-18) for white and black participants, respectively); missense rs2231142 in ABCG2 (p=2 times 5x10 super(-60) and 9 times 8x10 super(-4)), and rs1165205 in SLC17A3 (p=3 times 3x10 super(-26) and 0.33). All SNPs were direction-consistent with gout in white participants: rs16890979 (OR 0 times 59 per T allele, 95% CI 0 times 52-0.68, p=7 times 0x10 super(-14)), rs2231142 (1 times 74, 1 times 51-1 times 99, p=3 times 3x10 super(-15)), and rs1165205 (0 times 85, 0 times 77-0 times 94, p=0 times 002). In black partidpants of the ARIC study, rs2231142 was direction-consistent with gout (1 times 71, 1 times 06-2 times 77, p=0 times 028). An additive genetic risk score of high-risk alleles at the three loci showed graded associations with uric add (272-351 mu mol/L in the Framingham cohort, 269-386 mu mol/L in the Rotterdam cohort, and 303-426 mu mol/L in white participants of the ARIC study) and gout (frequency 2-13% in the Framingham cohort, 2-8% in the Rotterdam cohort, and 1-18% in white participants in the ARIC study). Interpretation We identified three genetic loci associated with uric add concentration and gout. A score based on genes with a putative role in renal urate handling showed a substantial risk for gout Funding Netherlands Organisation for Scientific Research (NWO); the National Heart, Lung, and Blood Institute. JF - Lancet AU - Dehghan, A AU - Koettgen, A AU - Yang, Q AU - Hwang, S-J AU - Kao, WHL AU - Rivadeneira, F AU - Boerwinkle, E AU - Levy, D AU - Hofman, A AU - Astor, B C AU - Benjamin, E J AU - van Duijn, CM AU - Wittemant, J C AU - Coresht, J AU - Foxt, C S AD - National Heart Lung and Blood Institute, the Framingham Heart Study, 73 Mount Wayte Avenue Suite 2, Framinqham, MA 01702, USA, foxca@nhlbi.nih.gov Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 1953 EP - 1961 VL - 372 IS - 9654 SN - 0140-6736, 0140-6736 KW - Genetics Abstracts; Risk Abstracts KW - Heart KW - Netherlands, Rotterdam KW - Gout KW - Blood KW - Renal function KW - Single-nucleotide polymorphism KW - Lung KW - Risk factors KW - Reviews KW - Kidney KW - Risk groups KW - Netherlands KW - Additives KW - Uric acid KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20734936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Association+of+three+genetic+loci+with+uric+acid+concentration+and+risk+of+gout%3A+a+genome-wide+association+study&rft.au=Dehghan%2C+A%3BKoettgen%2C+A%3BYang%2C+Q%3BHwang%2C+S-J%3BKao%2C+WHL%3BRivadeneira%2C+F%3BBoerwinkle%2C+E%3BLevy%2C+D%3BHofman%2C+A%3BAstor%2C+B+C%3BBenjamin%2C+E+J%3Bvan+Duijn%2C+CM%3BWittemant%2C+J+C%3BCoresht%2C+J%3BFoxt%2C+C+S&rft.aulast=Dehghan&rft.aufirst=A&rft.date=2008-12-12&rft.volume=372&rft.issue=9654&rft.spage=1953&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2808%2961343-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Blood; Renal function; Lung; Single-nucleotide polymorphism; Reviews; Risk factors; Kidney; Risk groups; Gout; Uric acid; Additives; Netherlands, Rotterdam; Netherlands DO - http://dx.doi.org/10.1016/S0140-6736(08)61343-4 ER - TY - JOUR T1 - The High-Resolution NMR Structure of the Early Folding Intermediate of the Thermus thermophilus Ribonuclease H AN - 19805151; 8851096 AB - Elucidation of the high-resolution structures of folding intermediates is a necessary but difficult step toward the ultimate understanding of the mechanism of protein folding. Here, using hydrogen-exchange-directed protein engineering, we populated the folding intermediate of the Thermus thermophilus ribonuclease H, which forms before the rate-limiting transition state, by removing the unfolded regions of the intermediate, including an a-helix and two b-strands (51 folded residues). Using multidimensional NMR, we solved the structure of this intermediate mimic to an atomic resolution (backbone rmsd, 0.51 A). It has a native-like backbone topology and shows some local deviations from the native structure, revealing that the structure of the folded region of an early folding intermediate can be as well defined as the native structure. The topological parameters calculated from the structures of the intermediate mimic and the native state predict that the intermediate should fold on a millisecond time scale or less and form much faster than the native state. Other factors that may lead to the slow folding of the native state and the accumulation of the intermediate before the rate-limiting transition state are also discussed. JF - Journal of Molecular Biology AU - Zhou, Z AU - Feng, H AU - Ghirlando, R AU - Bai, Y AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, yawen@helix.nih.gov Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 531 EP - 539 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 384 IS - 2 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; ASFA 1: Biological Sciences & Living Resources KW - Protein folding KW - Protein engineering KW - Biochemistry KW - Ribonuclease H KW - Microorganisms KW - N.M.R. KW - Thermus thermophilus KW - Q1 08206:Physiology, biochemistry, biophysics KW - J 02320:Cell Biology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19805151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=The+High-Resolution+NMR+Structure+of+the+Early+Folding+Intermediate+of+the+Thermus+thermophilus+Ribonuclease+H&rft.au=Zhou%2C+Z%3BFeng%2C+H%3BGhirlando%2C+R%3BBai%2C+Y&rft.aulast=Zhou&rft.aufirst=Z&rft.date=2008-12-12&rft.volume=384&rft.issue=2&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2008.09.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Biochemistry; Microorganisms; Protein engineering; Protein folding; Ribonuclease H; N.M.R.; Thermus thermophilus DO - http://dx.doi.org/10.1016/j.jmb.2008.09.044 ER - TY - JOUR T1 - Urethane and N-nitrosodiethylamine are mutagenic for the Syrian hamster fetus. AN - 69827926; 18755288 AB - Urethane and N-nitrosodiethylamine are soluble environmental carcinogens that initiate tumors transplacentally, but have a mixed history of effectiveness in mutagenesis assays in vitro or in vivo with adult rodents. To test for their transplacental mutagenicity, Syrian hamster fetuses at 12 days in gestation were exposed transplacentally to urethane or N-nitrosodiethylamine at 0.5 or 1.0 mM/kg. The fetal cells were isolated on day 13 of gestation and tested for diphtheria toxin resistance as a mutation marker. Both compounds were significantly mutagenic, at both doses, causing 6- to 20-fold increases in mutations compared with controls. Compared with N-nitrosodiethylamine, urethane was somewhat more effective as a mutagen with a more marked dose-response. These results are consistent with mutagenesis as part of the mechanism of transplacental carcinogenicity of urethane and N-nitrosodiethylamine. JF - Mutation research AU - Donovan, Paul J AU - Smith, George T AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538, Room 205 NCI-Frederick, Frederick, MD 21702-1201, USA. donovapa@mail.nih.gov Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 SP - 160 EP - 163 VL - 657 IS - 2 SN - 0027-5107, 0027-5107 KW - Alkylating Agents KW - 0 KW - Carcinogens KW - Mutagens KW - Urethane KW - 3IN71E75Z5 KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Index Medicus KW - Animals KW - Mutation KW - Female KW - Pregnancy KW - Cricetinae KW - Diethylnitrosamine -- toxicity KW - Fetus -- drug effects KW - Carcinogens -- toxicity KW - Mutagens -- toxicity KW - Alkylating Agents -- toxicity KW - Urethane -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69827926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Urethane+and+N-nitrosodiethylamine+are+mutagenic+for+the+Syrian+hamster+fetus.&rft.au=Donovan%2C+Paul+J%3BSmith%2C+George+T&rft.aulast=Donovan&rft.aufirst=Paul&rft.date=2008-12-08&rft.volume=657&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2008.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2008.07.011 ER - TY - CPAPER T1 - An Improved Estimator of Variance Explained in the Presence of Noise T2 - Twenty-Second Annual Conference on Neural Information Processing Systems (NIPS 2008) AN - 41973843; 5130017 JF - Twenty-Second Annual Conference on Neural Information Processing Systems (NIPS 2008) AU - Haefner, Ralf AU - Cumming, Bruce Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41973843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Twenty-Second+Annual+Conference+on+Neural+Information+Processing+Systems+%28NIPS+2008%29&rft.atitle=An+Improved+Estimator+of+Variance+Explained+in+the+Presence+of+Noise&rft.au=Haefner%2C+Ralf%3BCumming%2C+Bruce&rft.aulast=Haefner&rft.aufirst=Ralf&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Twenty-Second+Annual+Conference+on+Neural+Information+Processing+Systems+%28NIPS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://nips.cc/Conferences/2008/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Collaborative Learning by Boosting in Distributed Environments T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41721764; 4987087 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Wang, Shijun AU - Zhang, Changshui Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41721764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Collaborative+Learning+by+Boosting+in+Distributed+Environments&rft.au=Wang%2C+Shijun%3BZhang%2C+Changshui&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Anatomical Landmarks in Human Colon from Computed Tomographic Colonography Images T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41706111; 4986926 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Chowdhury, Ananda AU - Yao, Jianhua AU - Van Uitert, Robert AU - Linguraru, Marius AU - Summers, Ronald Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Colon KW - Computed tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41706111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Detection+of+Anatomical+Landmarks+in+Human+Colon+from+Computed+Tomographic+Colonography+Images&rft.au=Chowdhury%2C+Ananda%3BYao%2C+Jianhua%3BVan+Uitert%2C+Robert%3BLinguraru%2C+Marius%3BSummers%2C+Ronald&rft.aulast=Chowdhury&rft.aufirst=Ananda&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Matching Colonic Polyps from Prone and Supine CT Colonography Scans Based on Statistical Curvature Information T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41705364; 4986949 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Wang, Shijun AU - Yao, Jianhua AU - Summers, Ronald Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Polyps KW - Statistics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41705364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Matching+Colonic+Polyps+from+Prone+and+Supine+CT+Colonography+Scans+Based+on+Statistical+Curvature+Information&rft.au=Wang%2C+Shijun%3BYao%2C+Jianhua%3BSummers%2C+Ronald&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cervicographic Image Retrieval by Spatial Similarity of Lesions T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41656636; 4987455 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Xue, Zhiyun AU - Long, L AU - Antani, Sameer AU - Thoma, George AU - Jeronimo, Jose Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Lesions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41656636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Cervicographic+Image+Retrieval+by+Spatial+Similarity+of+Lesions&rft.au=Xue%2C+Zhiyun%3BLong%2C+L%3BAntani%2C+Sameer%3BThoma%2C+George%3BJeronimo%2C+Jose&rft.aulast=Xue&rft.aufirst=Zhiyun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biological Functions of Membrane-Type Matrix Metalloproteinases T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41899422; 5091696 JF - 2008 Meeting of the American Society for Matrix Biology AU - Holmbeck, Kenn Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Matrix metalloproteinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Biological+Functions+of+Membrane-Type+Matrix+Metalloproteinases&rft.au=Holmbeck%2C+Kenn&rft.aulast=Holmbeck&rft.aufirst=Kenn&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Early Inflammatory Response to Bites of Leishmania Major Infected Phlebotomus Duboscqi Sand Flies in NaiVe and Pre -Exposed Mice T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41897139; 5079979 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Teixeira, Clarissa AU - Oliveira, Luis AU - Gomes, Regis AU - Elnaiem, Dia AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Bites KW - Mice KW - Sand KW - Inflammation KW - Leishmania major KW - Phlebotomus duboscqi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Characterization+of+the+Early+Inflammatory+Response+to+Bites+of+Leishmania+Major+Infected+Phlebotomus+Duboscqi+Sand+Flies+in+NaiVe+and+Pre+-Exposed+Mice&rft.au=Teixeira%2C+Clarissa%3BOliveira%2C+Luis%3BGomes%2C+Regis%3BElnaiem%2C+Dia%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Teixeira&rft.aufirst=Clarissa&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discovery of Leishmania Parasite -Sandfly Interaction Targets for Transmission -Blocking and /or Sandfly -Killing Vaccines T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41896637; 5080273 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Vaccines KW - Disease control KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41896637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Discovery+of+Leishmania+Parasite+-Sandfly+Interaction+Targets+for+Transmission+-Blocking+and+%2For+Sandfly+-Killing+Vaccines&rft.au=Valenzuela%2C+Jesus&rft.aulast=Valenzuela&rft.aufirst=Jesus&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutual Stabilization of P3H1 and CRTAP in ER Modification Complex T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41888893; 5091903 JF - 2008 Meeting of the American Society for Matrix Biology AU - Chang, W AU - Barnes, A AU - Cabral, W AU - Marini, J Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Stabilizing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Mutual+Stabilization+of+P3H1+and+CRTAP+in+ER+Modification+Complex&rft.au=Chang%2C+W%3BBarnes%2C+A%3BCabral%2C+W%3BMarini%2C+J&rft.aulast=Chang&rft.aufirst=W&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Basement Membrane Remodeling During Branching Morphogenesis: The Dynamic Interplay of Proteolysis and Proliferation T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41888867; 5091735 JF - 2008 Meeting of the American Society for Matrix Biology AU - Hoffman, Matthew Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Membranes KW - Proteolysis KW - Morphogenesis KW - Basement membranes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Basement+Membrane+Remodeling+During+Branching+Morphogenesis%3A+The+Dynamic+Interplay+of+Proteolysis+and+Proliferation&rft.au=Hoffman%2C+Matthew&rft.aulast=Hoffman&rft.aufirst=Matthew&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Confocal Microscopy Study of Decorin Binding to Collagen Fibrils T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41885384; 5091897 JF - 2008 Meeting of the American Society for Matrix Biology AU - Makareeva, Elena AU - Sutter, Mary AU - DeRidder, Angela AU - Forlino, Antonella AU - Rossi, Antonio AU - Tenni, Ruggero AU - Leikin, Sergey Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Confocal microscopy KW - Decorin KW - Collagen KW - Fibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41885384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Confocal+Microscopy+Study+of+Decorin+Binding+to+Collagen+Fibrils&rft.au=Makareeva%2C+Elena%3BSutter%2C+Mary%3BDeRidder%2C+Angela%3BForlino%2C+Antonella%3BRossi%2C+Antonio%3BTenni%2C+Ruggero%3BLeikin%2C+Sergey&rft.aulast=Makareeva&rft.aufirst=Elena&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Institutes of Health /Fogarty International Center Support to Build Research Capacity T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41884910; 5079190 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sina, Barbara Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41884910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=National+Institutes+of+Health+%2FFogarty+International+Center+Support+to+Build+Research+Capacity&rft.au=Sina%2C+Barbara&rft.aulast=Sina&rft.aufirst=Barbara&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct OI Phenotype Caused by COL1 C-proteinase Site Mutations T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41877171; 5091868 JF - 2008 Meeting of the American Society for Matrix Biology AU - Barnes, A AU - Lindahl, K AU - Whyte, M AU - Hefferan, T AU - Rubin, C-J AU - Kindmark, A AU - McAlister, W AU - Mumm, S AU - Ljunggren, O AU - Marini, J Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mutation KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Distinct+OI+Phenotype+Caused+by+COL1+C-proteinase+Site+Mutations&rft.au=Barnes%2C+A%3BLindahl%2C+K%3BWhyte%2C+M%3BHefferan%2C+T%3BRubin%2C+C-J%3BKindmark%2C+A%3BMcAlister%2C+W%3BMumm%2C+S%3BLjunggren%2C+O%3BMarini%2C+J&rft.aulast=Barnes&rft.aufirst=A&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DMP1 Isoforms Promote Differential Cell Attachment and Migration T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41873107; 5091703 JF - 2008 Meeting of the American Society for Matrix Biology AU - von Marschall, Zofia Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Migration KW - Cell adhesion KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41873107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=DMP1+Isoforms+Promote+Differential+Cell+Attachment+and+Migration&rft.au=von+Marschall%2C+Zofia&rft.aulast=von+Marschall&rft.aufirst=Zofia&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building Research and Human Capacity One Link at a Time : the National Library of Medicine 's International Information Interventions T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872876; 5080194 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Royall, Julia Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Building+Research+and+Human+Capacity+One+Link+at+a+Time+%3A+the+National+Library+of+Medicine+%27s+International+Information+Interventions&rft.au=Royall%2C+Julia&rft.aulast=Royall&rft.aufirst=Julia&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of Invasive Long Lived Plasmodium Falciparum Merozoites by Cell Sieving T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872465; 5079893 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Narum, David AU - Haynes, J AU - Moch, J AU - Dutta, Sheetij Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Merozoites KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Isolation+of+Invasive+Long+Lived+Plasmodium+Falciparum+Merozoites+by+Cell+Sieving&rft.au=Narum%2C+David%3BHaynes%2C+J%3BMoch%2C+J%3BDutta%2C+Sheetij&rft.aulast=Narum&rft.aufirst=David&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post -treatment reactions in loiasis : looking towards the future T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872284; 5079845 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Klion, Amy Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Post+-treatment+reactions+in+loiasis+%3A+looking+towards+the+future&rft.au=Klion%2C+Amy&rft.aulast=Klion&rft.aufirst=Amy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complexity of the Tick Salivary Gland Transcriptome and Proteome T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41871969; 5079779 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ribeiro, Jose Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Gene expression KW - Salivary gland KW - Glands KW - Ixodidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41871969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Complexity+of+the+Tick+Salivary+Gland+Transcriptome+and+Proteome&rft.au=Ribeiro%2C+Jose&rft.aulast=Ribeiro&rft.aufirst=Jose&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thrombospondin-1 Regulates Blood Pressure and Cardiac Response T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41871555; 5091823 JF - 2008 Meeting of the American Society for Matrix Biology AU - Isenberg, Jeff AU - Qin, Yan AU - Despres, Daryl AU - Bandle, Russell AU - Schnermann, Jurgen AU - Frazier, William AU - Roberts, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Thrombospondin KW - Blood pressure KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41871555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Thrombospondin-1+Regulates+Blood+Pressure+and+Cardiac+Response&rft.au=Isenberg%2C+Jeff%3BQin%2C+Yan%3BDespres%2C+Daryl%3BBandle%2C+Russell%3BSchnermann%2C+Jurgen%3BFrazier%2C+William%3BRoberts%2C+David&rft.aulast=Isenberg&rft.aufirst=Jeff&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Anti -ama1 Antibodies Induced by ama1-c2, a Three -Allele Combination Vaccine T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41868786; 5078727 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Murray, Sara AU - Zhou, Hong AU - Aebig, Joan AU - Lambert, Lynn AU - Martin, Laura AU - Miller, Louis AU - Long, Carole AU - Miura, Kazutoyo Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Antibodies KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Characterization+of+Anti+-ama1+Antibodies+Induced+by+ama1-c2%2C+a+Three+-Allele+Combination+Vaccine&rft.au=Murray%2C+Sara%3BZhou%2C+Hong%3BAebig%2C+Joan%3BLambert%2C+Lynn%3BMartin%2C+Laura%3BMiller%2C+Louis%3BLong%2C+Carole%3BMiura%2C+Kazutoyo&rft.aulast=Murray&rft.aufirst=Sara&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of a Serine Protease from A. Gambiae in Plasmodium Development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41868573; 5079614 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rodrigues, Janneth AU - Abban, Ekua AU - Ortega, Corrie AU - Molina-Cruz, Alvaro AU - Barillas Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Serine proteinase KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Role+of+a+Serine+Protease+from+A.+Gambiae+in+Plasmodium+Development&rft.au=Rodrigues%2C+Janneth%3BAbban%2C+Ekua%3BOrtega%2C+Corrie%3BMolina-Cruz%2C+Alvaro%3BBarillas+Mury%2C+Carolina&rft.aulast=Rodrigues&rft.aufirst=Janneth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro Assessment of Taenia crassiceps Motility and its Application to the Study of Anthelmintic Treatment in Neurocysticercosis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41867556; 5078802 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Scott, Erick AU - Kabat, Juraj AU - Schwartz, Owen AU - Nash, Theodore AU - Mahanty, Siddhartha Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Motility KW - Cysticercosis KW - Taenia KW - Taenia crassiceps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=In+vitro+Assessment+of+Taenia+crassiceps+Motility+and+its+Application+to+the+Study+of+Anthelmintic+Treatment+in+Neurocysticercosis&rft.au=Scott%2C+Erick%3BKabat%2C+Juraj%3BSchwartz%2C+Owen%3BNash%2C+Theodore%3BMahanty%2C+Siddhartha&rft.aulast=Scott&rft.aufirst=Erick&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profiling protective humoral immune responses to Plasmodium falciparum by protein microarray in a longitudinal study in Mali T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41867131; 5079544 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Crompton, Peter AU - Kayala, Matt AU - Traore, Boubacar AU - Weiss, Greta AU - Burk, Chad AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Doumbo, Safiatou AU - Miller, Louis AU - Doumbo, Ogobara AU - Doolan, Denise AU - Baldi, Pierre AU - Felgner, Philip AU - Pierce, Susan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Longitudinal studies KW - Protein arrays KW - Immune response (humoral) KW - Parasites KW - Profiling KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Profiling+protective+humoral+immune+responses+to+Plasmodium+falciparum+by+protein+microarray+in+a+longitudinal+study+in+Mali&rft.au=Crompton%2C+Peter%3BKayala%2C+Matt%3BTraore%2C+Boubacar%3BWeiss%2C+Greta%3BBurk%2C+Chad%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BDoumbo%2C+Safiatou%3BMiller%2C+Louis%3BDoumbo%2C+Ogobara%3BDoolan%2C+Denise%3BBaldi%2C+Pierre%3BFelgner%2C+Philip%3BPierce%2C+Susan&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The impact of access to primary health care on the incidence of clinical malaria in children T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41861292; 5079540 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - O'Meara, Wendy AU - Noor, Abdisalan AU - Tsofa, Benjamin AU - McKenzie, F AU - Marsh, Kevin Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Children KW - Malaria KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+impact+of+access+to+primary+health+care+on+the+incidence+of+clinical+malaria+in+children&rft.au=O%27Meara%2C+Wendy%3BNoor%2C+Abdisalan%3BTsofa%2C+Benjamin%3BMcKenzie%2C+F%3BMarsh%2C+Kevin&rft.aulast=O%27Meara&rft.aufirst=Wendy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and molecular cataloging of hemocyte specific immune genes from malaria vector A. gambiae T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41860759; 5080128 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Dixit, Rajnikant AU - Kumar, Sanjeev AU - Gupta, Lalita AU - Molina-Cruz, Alvaro AU - Rodrigues, Janneth AU - Valenzuela, Jesus AU - Ribeiro, Jose AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Malaria KW - Vectors KW - Hemocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Identification+and+molecular+cataloging+of+hemocyte+specific+immune+genes+from+malaria+vector+A.+gambiae&rft.au=Dixit%2C+Rajnikant%3BKumar%2C+Sanjeev%3BGupta%2C+Lalita%3BMolina-Cruz%2C+Alvaro%3BRodrigues%2C+Janneth%3BValenzuela%2C+Jesus%3BRibeiro%2C+Jose%3BBarillas-Mury%2C+Carolina&rft.aulast=Dixit&rft.aufirst=Rajnikant&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Does Plasmodium Evade the Mosquito 'S Immune System ? T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41860423; 5079240 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immune system KW - Aquatic insects KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=How+Does+Plasmodium+Evade+the+Mosquito+%27S+Immune+System+%3F&rft.au=Barillas-Mury%2C+Carolina&rft.aulast=Barillas-Mury&rft.aufirst=Carolina&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MSCs create a TIMP-rich, matrix-protective local environment T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41859176; 5091830 JF - 2008 Meeting of the American Society for Matrix Biology AU - Lozito, Thomas AU - White, Cassie AU - Kuo, Catherine AU - Taboas, Juan AU - Tuan, Rocky Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=MSCs+create+a+TIMP-rich%2C+matrix-protective+local+environment&rft.au=Lozito%2C+Thomas%3BWhite%2C+Cassie%3BKuo%2C+Catherine%3BTaboas%2C+Juan%3BTuan%2C+Rocky&rft.aulast=Lozito&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ECMPs act as centers of MMP activation and matrix remodeling T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41859135; 5091829 JF - 2008 Meeting of the American Society for Matrix Biology AU - Lozito, Thomas AU - White, Cassie AU - Kuo, Catherine AU - Taboas, Juan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=ECMPs+act+as+centers+of+MMP+activation+and+matrix+remodeling&rft.au=Lozito%2C+Thomas%3BWhite%2C+Cassie%3BKuo%2C+Catherine%3BTaboas%2C+Juan&rft.aulast=Lozito&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Humans from an endemic area of cutaneous leishmaniasis in Mali produce IFN-gamma to sand fly salivary proteins T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857936; 5079924 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Oliveira, Fabiano AU - Gomes, Regis AU - Teixeira, Clarissa AU - Faye, Ousmane AU - Traore, Pierre AU - Diarra, Souleymane AU - Anderson, Jeniffer AU - Dia-Eldin, Elnaiem AU - Samake, Sibiry AU - Traore, Bourama AU - Coulibaly, Cheick AU - Rick, Fairhurst AU - Keita, Somita AU - Doumbia, Seydou AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Sand KW - G-Interferon KW - Cutaneous leishmaniasis KW - Endemic species KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Humans+from+an+endemic+area+of+cutaneous+leishmaniasis+in+Mali+produce+IFN-gamma+to+sand+fly+salivary+proteins&rft.au=Oliveira%2C+Fabiano%3BGomes%2C+Regis%3BTeixeira%2C+Clarissa%3BFaye%2C+Ousmane%3BTraore%2C+Pierre%3BDiarra%2C+Souleymane%3BAnderson%2C+Jeniffer%3BDia-Eldin%2C+Elnaiem%3BSamake%2C+Sibiry%3BTraore%2C+Bourama%3BCoulibaly%2C+Cheick%3BRick%2C+Fairhurst%3BKeita%2C+Somita%3BDoumbia%2C+Seydou%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Oliveira&rft.aufirst=Fabiano&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loa loa : a clinical overview T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857790; 5079842 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Loa+loa+%3A+a+clinical+overview&rft.au=Nutman%2C+Thomas&rft.aulast=Nutman&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lutzomyia longipalpis recombinant salivary yellow -related protein (LJM11) confers protection against leishmania infected sand flies T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857775; 5079976 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Gomes, Regis AU - Oliveira, Fabiano AU - Teixeira, Clarissa AU - Elnaiem, Dia-Eldin AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Sand KW - Recombinants KW - Lutzomyia longipalpis KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Lutzomyia+longipalpis+recombinant+salivary+yellow+-related+protein+%28LJM11%29+confers+protection+against+leishmania+infected+sand+flies&rft.au=Gomes%2C+Regis%3BOliveira%2C+Fabiano%3BTeixeira%2C+Clarissa%3BElnaiem%2C+Dia-Eldin%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Gomes&rft.aufirst=Regis&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Type I collagen homotrimers may alter tissue remodeling T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41857730; 5091809 JF - 2008 Meeting of the American Society for Matrix Biology AU - Han, Sejin AU - Makareeva, Elena AU - McBride, Daniel AU - Phillips, Charlotte AU - Schwarze, Ulrike AU - Pace, James AU - Byers, Peter AU - Visse, Robert AU - Nagase, Hideaki AU - Leikin, Sergey Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Collagen (type I) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Type+I+collagen+homotrimers+may+alter+tissue+remodeling&rft.au=Han%2C+Sejin%3BMakareeva%2C+Elena%3BMcBride%2C+Daniel%3BPhillips%2C+Charlotte%3BSchwarze%2C+Ulrike%3BPace%2C+James%3BByers%2C+Peter%3BVisse%2C+Robert%3BNagase%2C+Hideaki%3BLeikin%2C+Sergey&rft.aulast=Han&rft.aufirst=Sejin&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A tep1 Mediated Response Is Required but Not Sufficient for Melanization of Plasmodium Falciprum in the Anopheles Gambiae Midgut T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857482; 5080283 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Molina-Cruz, Alvaro AU - Ortega, Corrie AU - DeJong, Randall AU - Rodrigues, Janneth AU - Jaramillo-Gutierrez, Giovanna AU - Abban, Ekua AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Midgut KW - Melanization KW - Aquatic insects KW - Plasmodium KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+tep1+Mediated+Response+Is+Required+but+Not+Sufficient+for+Melanization+of+Plasmodium+Falciprum+in+the+Anopheles+Gambiae+Midgut&rft.au=Molina-Cruz%2C+Alvaro%3BOrtega%2C+Corrie%3BDeJong%2C+Randall%3BRodrigues%2C+Janneth%3BJaramillo-Gutierrez%2C+Giovanna%3BAbban%2C+Ekua%3BBarillas-Mury%2C+Carolina&rft.aulast=Molina-Cruz&rft.aufirst=Alvaro&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing the correlation between Growth Inhibition activity and malaria risk in a longitudinal study in Mali T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857209; 5079543 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Crompton, Peter AU - Miura, Kazutoyo AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Weiss, Greta AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Huang, Chiung-Yu AU - Doumbo, Ogobara AU - Miller, Louis AU - Long, Carole AU - Pierce, Susan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Longitudinal studies KW - Malaria KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Assessing+the+correlation+between+Growth+Inhibition+activity+and+malaria+risk+in+a+longitudinal+study+in+Mali&rft.au=Crompton%2C+Peter%3BMiura%2C+Kazutoyo%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BWeiss%2C+Greta%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BHuang%2C+Chiung-Yu%3BDoumbo%2C+Ogobara%3BMiller%2C+Louis%3BLong%2C+Carole%3BPierce%2C+Susan&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracellular Matrix Control of Stem Cell Niches T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41856585; 5091682 JF - 2008 Meeting of the American Society for Matrix Biology AU - Young, Marian Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Stem cells KW - Niches KW - Extracellular matrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Extracellular+Matrix+Control+of+Stem+Cell+Niches&rft.au=Young%2C+Marian&rft.aulast=Young&rft.aufirst=Marian&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neutrophils Are the Predominant Initial Host Cell for Leishmania Major and Are Essential for the Establishment of Sand Fly Transmitted Infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41856528; 5080344 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Peters, Nathan AU - Egen, Jackson AU - Secundino, Naglia AU - Debrabant, Alain AU - Kimblin, Nicola AU - Kamhawi, Shaden AU - Lawyer, Phillip AU - Germain, Ronald AU - Sacks, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Sand KW - Leukocytes (neutrophilic) KW - Leishmania major KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Neutrophils+Are+the+Predominant+Initial+Host+Cell+for+Leishmania+Major+and+Are+Essential+for+the+Establishment+of+Sand+Fly+Transmitted+Infection&rft.au=Peters%2C+Nathan%3BEgen%2C+Jackson%3BSecundino%2C+Naglia%3BDebrabant%2C+Alain%3BKimblin%2C+Nicola%3BKamhawi%2C+Shaden%3BLawyer%2C+Phillip%3BGermain%2C+Ronald%3BSacks%2C+David&rft.aulast=Peters&rft.aufirst=Nathan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide Depletion and Endothelial Dysfunction in Children with Malaria and Marked Anemia T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41856365; 5080320 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Janka, Jacqueline AU - Koita, Ousmane AU - Josepha, Maya AU - Traore, Broulaye AU - Mzayek, Fawaz AU - Sangare, Lansana AU - Cisse, Ousmane AU - Mendelsohn, Laurel AU - Wang, Xunde AU - Masur, Henry AU - Gladwin, Mark AU - Krogstad, Donald Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Anemia KW - Children KW - Malaria KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Nitric+Oxide+Depletion+and+Endothelial+Dysfunction+in+Children+with+Malaria+and+Marked+Anemia&rft.au=Janka%2C+Jacqueline%3BKoita%2C+Ousmane%3BJosepha%2C+Maya%3BTraore%2C+Broulaye%3BMzayek%2C+Fawaz%3BSangare%2C+Lansana%3BCisse%2C+Ousmane%3BMendelsohn%2C+Laurel%3BWang%2C+Xunde%3BMasur%2C+Henry%3BGladwin%2C+Mark%3BKrogstad%2C+Donald&rft.aulast=Janka&rft.aufirst=Jacqueline&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of human H5N1 disease in SEA with emphasis on epidemiology and clinical outcomes in H5N1 T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855255; 5079876 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sedyaningsih, Endang Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Reviews KW - Epidemiology KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Overview+of+human+H5N1+disease+in+SEA+with+emphasis+on+epidemiology+and+clinical+outcomes+in+H5N1&rft.au=Sedyaningsih%2C+Endang&rft.aulast=Sedyaningsih&rft.aufirst=Endang&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of IgM capture ELISA assays for the detection anti -JEV IgM antibodies in cerebrospinal fluid samples T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855101; 5079828 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Vasanthapuram, Ravi AU - Robinson, Jamie AU - Russell, Brandy AU - Desai, Anita AU - Ramamurty, Nalini AU - Featherstone, David AU - Johnson, Barbara Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immunoglobulin M KW - Cerebrospinal fluid KW - ELISA KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Evaluation+of+IgM+capture+ELISA+assays+for+the+detection+anti+-JEV+IgM+antibodies+in+cerebrospinal+fluid+samples&rft.au=Vasanthapuram%2C+Ravi%3BRobinson%2C+Jamie%3BRussell%2C+Brandy%3BDesai%2C+Anita%3BRamamurty%2C+Nalini%3BFeatherstone%2C+David%3BJohnson%2C+Barbara&rft.aulast=Vasanthapuram&rft.aufirst=Ravi&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The role of human dendritic cells in filarial infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855048; 5079815 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Semnani, Roshanak Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+role+of+human+dendritic+cells+in+filarial+infection&rft.au=Semnani%2C+Roshanak&rft.aulast=Semnani&rft.aufirst=Roshanak&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of miRNAs that regulate epithelial morphogenesis during submandibular gland development T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41853541; 5091936 JF - 2008 Meeting of the American Society for Matrix Biology AU - Rebustini, I AU - Reynolds, A AU - Hoffman, M Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - MiRNA KW - Submandibular gland KW - Morphogenesis KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Identification+of+miRNAs+that+regulate+epithelial+morphogenesis+during+submandibular+gland+development&rft.au=Rebustini%2C+I%3BReynolds%2C+A%3BHoffman%2C+M&rft.aulast=Rebustini&rft.aufirst=I&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/2008%20ASMB%20Addendum.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Phase 1 study of the blood stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41852912; 5079565 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ellis, Ruth AU - Martin, Laura AU - Pierce, Mark AU - Miura, Kazutoyo AU - Mullen, Gregory AU - Fay, Michael AU - Long, Carole AU - Shaffer, Donna AU - Saul, Allan AU - Miller, Louis AU - Durbin, Anna Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Blood KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Phase+1+study+of+the+blood+stage+malaria+vaccine+candidate+AMA1-C1%2FAlhydrogel+with+CPG+7909%2C+using+two+different+formulations+and+dosing+intervals&rft.au=Ellis%2C+Ruth%3BMartin%2C+Laura%3BPierce%2C+Mark%3BMiura%2C+Kazutoyo%3BMullen%2C+Gregory%3BFay%2C+Michael%3BLong%2C+Carole%3BShaffer%2C+Donna%3BSaul%2C+Allan%3BMiller%2C+Louis%3BDurbin%2C+Anna&rft.aulast=Ellis&rft.aufirst=Ruth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Filarial lymphatic pathology is characterized by augmented pro -inflammatory cytokine production in response to TLR2 and TLR9 ligands T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41852677; 5079275 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Babu, Subash AU - Bhat, Sajid AU - Kumar, Pavan AU - Kolappan, C AU - Kumaraswami, V AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Pathology KW - Toll-like receptors KW - TLR2 protein KW - Cytokines KW - TLR9 protein KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Filarial+lymphatic+pathology+is+characterized+by+augmented+pro+-inflammatory+cytokine+production+in+response+to+TLR2+and+TLR9+ligands&rft.au=Babu%2C+Subash%3BBhat%2C+Sajid%3BKumar%2C+Pavan%3BKolappan%2C+C%3BKumaraswami%2C+V%3BNutman%2C+Thomas&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Alum Formulation Immunoassay (Dafia): An Immunofluorescent Assay That Directly Determines the Content , Identity and Integrity of Antigens Formulated on Alhydrogel T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851905; 5080105 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Zhu, Daming AU - Huang, Shuhui AU - Gebregeorgis, Elizabeth AU - McClellan, Holly AU - Miller, Louis AU - Saul, Allan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immunoassays KW - Aluminum sulfate KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Direct+Alum+Formulation+Immunoassay+%28Dafia%29%3A+An+Immunofluorescent+Assay+That+Directly+Determines+the+Content+%2C+Identity+and+Integrity+of+Antigens+Formulated+on+Alhydrogel&rft.au=Zhu%2C+Daming%3BHuang%2C+Shuhui%3BGebregeorgis%2C+Elizabeth%3BMcClellan%2C+Holly%3BMiller%2C+Louis%3BSaul%2C+Allan&rft.aulast=Zhu&rft.aufirst=Daming&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions of Yersinia Pestis with Its Flea Vector That Underlie Stable Plague Transmission Cycles T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851447; 5080267 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Hinnebusch, B Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Disease transmission KW - Vectors KW - Plague KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Interactions+of+Yersinia+Pestis+with+Its+Flea+Vector+That+Underlie+Stable+Plague+Transmission+Cycles&rft.au=Hinnebusch%2C+B&rft.aulast=Hinnebusch&rft.aufirst=B&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Phase 1 Trial of the Malaria Transmission Blocking Vaccine Candidates Pfs 25 and Pvs 25 formulated with Montanide ISA 51 T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851443; 5078780 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ellis, Ruth AU - Wu, Yimin AU - Shaffer, Donna AU - Fontes, Erica AU - Malkin, Elissa AU - Mahanty, Siddhartha AU - Fay, Michael AU - Narum, David AU - Rausch, Kelly AU - Miles, Aaron AU - Aebig, Joan AU - Orcutt, Andrew AU - Muratova, Olga AU - Song, Guanhong AU - Lambert, Lynn AU - Zhu, Daming AU - Miura, Kazutoyo AU - Long, Carole AU - Saul, Allan AU - Miller, Louis AU - Durbin, Anna Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Disease transmission KW - Malaria KW - Fish diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Phase+1+Trial+of+the+Malaria+Transmission+Blocking+Vaccine+Candidates+Pfs+25+and+Pvs+25+formulated+with+Montanide+ISA+51&rft.au=Ellis%2C+Ruth%3BWu%2C+Yimin%3BShaffer%2C+Donna%3BFontes%2C+Erica%3BMalkin%2C+Elissa%3BMahanty%2C+Siddhartha%3BFay%2C+Michael%3BNarum%2C+David%3BRausch%2C+Kelly%3BMiles%2C+Aaron%3BAebig%2C+Joan%3BOrcutt%2C+Andrew%3BMuratova%2C+Olga%3BSong%2C+Guanhong%3BLambert%2C+Lynn%3BZhu%2C+Daming%3BMiura%2C+Kazutoyo%3BLong%2C+Carole%3BSaul%2C+Allan%3BMiller%2C+Louis%3BDurbin%2C+Anna&rft.aulast=Ellis&rft.aufirst=Ruth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatio-temporal ordering of a Chagas disease vector elimination campaign T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41850661; 5079730 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Levy, Michael AU - Malaga, Fernando AU - Cornejo del Carpio, Juan AU - McKenzie, Ellis AU - Plotkin, Joshua Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Chagas' disease KW - Disease transmission KW - Hosts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41850661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Spatio-temporal+ordering+of+a+Chagas+disease+vector+elimination+campaign&rft.au=Levy%2C+Michael%3BMalaga%2C+Fernando%3BCornejo+del+Carpio%2C+Juan%3BMcKenzie%2C+Ellis%3BPlotkin%2C+Joshua&rft.aulast=Levy&rft.aufirst=Michael&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation technologies for malaria vaccine development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41849196; 5079699 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Long, Carole Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Technology KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Evaluation+technologies+for+malaria+vaccine+development&rft.au=Long%2C+Carole&rft.aulast=Long&rft.aufirst=Carole&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Frequency of Drug Resistance Mutations in dhfr, dhps , and pfcrt, on the Pacific Coast of Peru T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41849029; 5080084 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Arrospide, Nancy AU - Gutierrez, Sonia AU - Marquino, Wilmer AU - Ruebush, Trent Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Peru KW - Pacific KW - Mutation KW - Coastal zone KW - Drug resistance KW - Dihydrofolate reductase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+Frequency+of+Drug+Resistance+Mutations+in+dhfr%2C+dhps+%2C+and+pfcrt%2C+on+the+Pacific+Coast+of+Peru&rft.au=Arrospide%2C+Nancy%3BGutierrez%2C+Sonia%3BMarquino%2C+Wilmer%3BRuebush%2C+Trent&rft.aulast=Arrospide&rft.aufirst=Nancy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anti -Apical Membrane Antigen 1 Igg Is More Effective in Inhibiting Plasmodium Falciparum Growth as Measured by in Vitro Growth Inhibition Assay than Anti -Merozoite Surface Protein 1 42 Igg T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41848731; 5079575 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Miura, Kazutoyo AU - Zhou, Hong AU - Diouf, Ababacar AU - Moretz, Samuel AU - Miller, Louis AU - Martin, Laura AU - Mullen, Gregory AU - Long, Carole Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Membranes KW - Immunoglobulin G KW - Growth KW - Parasites KW - Antigens KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Anti+-Apical+Membrane+Antigen+1+Igg+Is+More+Effective+in+Inhibiting+Plasmodium+Falciparum+Growth+as+Measured+by+in+Vitro+Growth+Inhibition+Assay+than+Anti+-Merozoite+Surface+Protein+1+42+Igg&rft.au=Miura%2C+Kazutoyo%3BZhou%2C+Hong%3BDiouf%2C+Ababacar%3BMoretz%2C+Samuel%3BMiller%2C+Louis%3BMartin%2C+Laura%3BMullen%2C+Gregory%3BLong%2C+Carole&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative analysis of malaria vaccine candidate AMA1-C1/Alhydrogel with the addition of unique CpG sequences T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41848654; 5079568 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rausch, Kelly AU - Ramineni, Bhanumati AU - Lambert, Lynn AU - Miura, Kazutoyo AU - Barnafo, Emma AU - Long, Carole AU - Miller, Louis AU - Martin, Laura Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Comparative+analysis+of+malaria+vaccine+candidate+AMA1-C1%2FAlhydrogel+with+the+addition+of+unique+CpG+sequences&rft.au=Rausch%2C+Kelly%3BRamineni%2C+Bhanumati%3BLambert%2C+Lynn%3BMiura%2C+Kazutoyo%3BBarnafo%2C+Emma%3BLong%2C+Carole%3BMiller%2C+Louis%3BMartin%2C+Laura&rft.aulast=Rausch&rft.aufirst=Kelly&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of TRAIL- and TNF-?-dependent apoptotic cell death in human monocyte -derived dendritic cells by Brugia malayi T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41847988; 5079273 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Semnani, Roshanak AU - Venugopal, Priyanka AU - Mahapatra, Lily AU - Skinner, Jason AU - Meylan, Francoise AU - Chaussabel, Damien AU - Siegel, Richard AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mortality KW - Cell death KW - Dendritic cells KW - Apoptosis KW - Monocytes KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Induction+of+TRAIL-+and+TNF-%3F-dependent+apoptotic+cell+death+in+human+monocyte+-derived+dendritic+cells+by+Brugia+malayi&rft.au=Semnani%2C+Roshanak%3BVenugopal%2C+Priyanka%3BMahapatra%2C+Lily%3BSkinner%2C+Jason%3BMeylan%2C+Francoise%3BChaussabel%2C+Damien%3BSiegel%2C+Richard%3BNutman%2C+Thomas&rft.aulast=Semnani&rft.aufirst=Roshanak&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of acute Plasmodium vivax malaria with PyramaxRG (pyronaridine tetraphosphate /artesunate ) in a controlled Phase III clinical trial T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41847461; 5079923 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Tjitra, Emiliana AU - Ruangweerayut, Ronnatrai AU - Socheat, Duong AU - Valecha, Neena Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Clinical trials KW - Malaria KW - Artesunate KW - Pyronaridine KW - Public health KW - Plasmodium vivax KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Treatment+of+acute+Plasmodium+vivax+malaria+with+PyramaxRG+%28pyronaridine+tetraphosphate+%2Fartesunate+%29+in+a+controlled+Phase+III+clinical+trial&rft.au=Tjitra%2C+Emiliana%3BRuangweerayut%2C+Ronnatrai%3BSocheat%2C+Duong%3BValecha%2C+Neena&rft.aulast=Tjitra&rft.aufirst=Emiliana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in Exposure and Chronicity in Human Filarial Infection Leads to Variable Gene Expression Profiles T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846931; 5078917 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Steel, Cathy AU - Myers, Timothy AU - Su, Qin AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Differences+in+Exposure+and+Chronicity+in+Human+Filarial+Infection+Leads+to+Variable+Gene+Expression+Profiles&rft.au=Steel%2C+Cathy%3BMyers%2C+Timothy%3BSu%2C+Qin%3BNutman%2C+Thomas&rft.aulast=Steel&rft.aufirst=Cathy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Disruption of a Mechanosensitive Ion Channel in Plasmodium Falciparum T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846205; 5078995 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rayavara, Kempaiah AU - Desai, Sanjay Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Channels KW - Ion channels KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Genetic+Disruption+of+a+Mechanosensitive+Ion+Channel+in+Plasmodium+Falciparum&rft.au=Rayavara%2C+Kempaiah%3BDesai%2C+Sanjay&rft.aulast=Rayavara&rft.aufirst=Kempaiah&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Neonatal Murine Model of Enteroaggregative Escherichia coli Infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846197; 5078878 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Cabal, Ace AU - Roche, James AU - Sevilleja, Jesus AU - Nataro, James AU - Guerrant, Richard Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Neonates KW - Animal models KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Novel+Neonatal+Murine+Model+of+Enteroaggregative+Escherichia+coli+Infection&rft.au=Cabal%2C+Ace%3BRoche%2C+James%3BSevilleja%2C+Jesus%3BNataro%2C+James%3BGuerrant%2C+Richard&rft.aulast=Cabal&rft.aufirst=Ace&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Carrier Frequency for Recessive OI in West Africans T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41844241; 5091781 JF - 2008 Meeting of the American Society for Matrix Biology AU - Cabral, Wayne AU - Barnes, Aileen AU - Rotimi, Charles AU - Brody, Lawrence AU - Bailey-Wilson, Joan AU - Panny, Susan AU - Chitayat, David AU - Porter, Forbes AU - Marini, Joan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Africa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=High+Carrier+Frequency+for+Recessive+OI+in+West+Africans&rft.au=Cabral%2C+Wayne%3BBarnes%2C+Aileen%3BRotimi%2C+Charles%3BBrody%2C+Lawrence%3BBailey-Wilson%2C+Joan%3BPanny%2C+Susan%3BChitayat%2C+David%3BPorter%2C+Forbes%3BMarini%2C+Joan&rft.aulast=Cabral&rft.aufirst=Wayne&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the barriers preventing successful development of Plasmodium falciparum in Culex mosquitoes T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41840855; 5079693 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Hume, Jen AU - Lehmann, Tovi Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Aquatic insects KW - Parasites KW - Barriers KW - Plasmodium falciparum KW - Culex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41840855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Identification+of+the+barriers+preventing+successful+development+of+Plasmodium+falciparum+in+Culex+mosquitoes&rft.au=Hume%2C+Jen%3BLehmann%2C+Tovi&rft.aulast=Hume&rft.aufirst=Jen&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Drug Resistance Using Plasmodium Falciparum Genetic Crosses T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839959; 5079738 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sa, Juliana AU - Twu, Olivia AU - Hayton, Karen AU - Ringwald, Pascal AU - Wellems, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Drug resistance KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Analysis+of+Drug+Resistance+Using+Plasmodium+Falciparum+Genetic+Crosses&rft.au=Sa%2C+Juliana%3BTwu%2C+Olivia%3BHayton%2C+Karen%3BRingwald%2C+Pascal%3BWellems%2C+Thomas&rft.aulast=Sa&rft.aufirst=Juliana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adjuvants and other immunopotentiators for malaria vaccine development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839752; 5079701 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Seder, Robert Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Adjuvants KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Adjuvants+and+other+immunopotentiators+for+malaria+vaccine+development&rft.au=Seder%2C+Robert&rft.aulast=Seder&rft.aufirst=Robert&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccination with MSP142-C1/Alhydrogel RG generates antigen -specific memory B cells in malaria -naive U.S. adults and the CpG 7909 oligodeoxynucleotide adjuvant enhances this response T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839143; 5079546 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Mircetic, Marko AU - Weiss, Greta AU - Mullen, Gregory AU - Martin, Laura AU - Miller, Louis AU - Pierce, Susan AU - Crompton, Peter Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - USA KW - Malaria KW - Lymphocytes B KW - Memory cells KW - Vaccination KW - Oligonucleotides KW - Immunological memory KW - Adjuvants KW - CpG islands KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Vaccination+with+MSP142-C1%2FAlhydrogel+RG+generates+antigen+-specific+memory+B+cells+in+malaria+-naive+U.S.+adults+and+the+CpG+7909+oligodeoxynucleotide+adjuvant+enhances+this+response&rft.au=Mircetic%2C+Marko%3BWeiss%2C+Greta%3BMullen%2C+Gregory%3BMartin%2C+Laura%3BMiller%2C+Louis%3BPierce%2C+Susan%3BCrompton%2C+Peter&rft.aulast=Mircetic&rft.aufirst=Marko&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Searching for Molecular Determinants of Species Specificity in Sand Flies Colonized by Leishmania Parasites T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41838084; 5079906 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Jochim, Ryan AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Sand KW - Specificity KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Searching+for+Molecular+Determinants+of+Species+Specificity+in+Sand+Flies+Colonized+by+Leishmania+Parasites&rft.au=Jochim%2C+Ryan%3BValenzuela%2C+Jesus&rft.aulast=Jochim&rft.aufirst=Ryan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase 1 Safety and Immunogenicity Trial of a Blood -Stage Malaria Vaccine AMA1-C1/ISA 720 in Australian Adults T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41836562; 5080097 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Arden Pierce, Mark AU - Ellis, Ruth AU - Malkin, Elissa AU - Miura, Kazutoyo AU - Marjason, Joanne AU - Mullen, Gregory AU - Long, Carole AU - Miller, Louis AU - Martin, Laura Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Australia KW - Vaccines KW - Immunogenicity KW - Malaria KW - Blood KW - Fish diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41836562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Phase+1+Safety+and+Immunogenicity+Trial+of+a+Blood+-Stage+Malaria+Vaccine+AMA1-C1%2FISA+720+in+Australian+Adults&rft.au=Arden+Pierce%2C+Mark%3BEllis%2C+Ruth%3BMalkin%2C+Elissa%3BMiura%2C+Kazutoyo%3BMarjason%2C+Joanne%3BMullen%2C+Gregory%3BLong%2C+Carole%3BMiller%2C+Louis%3BMartin%2C+Laura&rft.aulast=Arden+Pierce&rft.aufirst=Mark&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intranasal Administration of a Salmonella -Based Vaccine Expressing cp15 Antigen Confers Protection in Neonatal Mice Challenged with Cryptosporidium Parvum T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41836188; 5079061 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Cabal, Ace AU - Manque, Patricio AU - Lara, Ana AU - Woehlbier, Ute AU - Roche, James AU - Sevilleja, Jesus AU - Rivers-Davis, Andrea AU - Buck, Gregory AU - Guerrant, Richard Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Mice KW - Neonates KW - Intranasal administration KW - Anadromous species KW - Antigens KW - Disease control KW - Salmonella KW - Cryptosporidium parvum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41836188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Intranasal+Administration+of+a+Salmonella+-Based+Vaccine+Expressing+cp15+Antigen+Confers+Protection+in+Neonatal+Mice+Challenged+with+Cryptosporidium+Parvum&rft.au=Cabal%2C+Ace%3BManque%2C+Patricio%3BLara%2C+Ana%3BWoehlbier%2C+Ute%3BRoche%2C+James%3BSevilleja%2C+Jesus%3BRivers-Davis%2C+Andrea%3BBuck%2C+Gregory%3BGuerrant%2C+Richard&rft.aulast=Cabal&rft.aufirst=Ace&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The biochemical and biophysical characterization of an Escherichia coli expressed Plasmodium falciparum circumsporozoite protein (CSP), a leading malaria vaccine candidate T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41835672; 5078726 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Plassmeyer, Matthew AU - MacDonald, Nick AU - Reiter, Karine AU - Shimp, Richard AU - Zhang, Yanling AU - House, Brent AU - Lebowitz, Jack AU - Kotova, Svetlana AU - Jin, Albert AU - Hickman, Merrit AU - Herrera, Raul AU - Uchime, Onyinyechukwu AU - Nguyen, Vu AU - Glen, Jacqueline AU - Miller, Louis AU - Wu, Yimin AU - Narum, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Biochemistry KW - Circumsporozoite protein KW - Parasites KW - Public health KW - Disease control KW - Escherichia coli KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41835672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+biochemical+and+biophysical+characterization+of+an+Escherichia+coli+expressed+Plasmodium+falciparum+circumsporozoite+protein+%28CSP%29%2C+a+leading+malaria+vaccine+candidate&rft.au=Plassmeyer%2C+Matthew%3BMacDonald%2C+Nick%3BReiter%2C+Karine%3BShimp%2C+Richard%3BZhang%2C+Yanling%3BHouse%2C+Brent%3BLebowitz%2C+Jack%3BKotova%2C+Svetlana%3BJin%2C+Albert%3BHickman%2C+Merrit%3BHerrera%2C+Raul%3BUchime%2C+Onyinyechukwu%3BNguyen%2C+Vu%3BGlen%2C+Jacqueline%3BMiller%2C+Louis%3BWu%2C+Yimin%3BNarum%2C+David&rft.aulast=Plassmeyer&rft.aufirst=Matthew&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Roles of Plasmodium Rhomboid 1 in Parasite Development and Malaria Pathogenesis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834909; 5079892 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Srinivasan, Prakash AU - Coppens, Isabelle AU - Jacobs-Lorena, Marcelo Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Malaria KW - Public health KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Distinct+Roles+of+Plasmodium+Rhomboid+1+in+Parasite+Development+and+Malaria+Pathogenesis&rft.au=Srinivasan%2C+Prakash%3BCoppens%2C+Isabelle%3BJacobs-Lorena%2C+Marcelo&rft.aulast=Srinivasan&rft.aufirst=Prakash&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The relationship between malaria transmission intensity , clinical disease and mortality in an area of declining transmission T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834818; 5079851 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - O'Meara, Wendy AU - Mwangi, Tabitha AU - Williams, Thomas AU - McKenzie, F AU - Snow, Robert AU - Marsh, Kevin Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Disease transmission KW - Mortality KW - Malaria KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+relationship+between+malaria+transmission+intensity+%2C+clinical+disease+and+mortality+in+an+area+of+declining+transmission&rft.au=O%27Meara%2C+Wendy%3BMwangi%2C+Tabitha%3BWilliams%2C+Thomas%3BMcKenzie%2C+F%3BSnow%2C+Robert%3BMarsh%2C+Kevin&rft.aulast=O%27Meara&rft.aufirst=Wendy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Production , characterization and immunological evaluation of an Escherichia coli expressed Plasmodium falciparum thrombospondin related apical merozoite protein (PTRAMP), a putative malaria vaccine candidate T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834541; 5080096 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Uchime, Onyinyechukwu AU - Reiter, Karine AU - Nguyen, Vu AU - Glen, Jacqueline AU - Miller, Louis AU - Narum, David AU - Plassmeyer, Matthew Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Thrombospondin KW - Merozoites KW - Parasites KW - Public health KW - Disease control KW - Escherichia coli KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Production+%2C+characterization+and+immunological+evaluation+of+an+Escherichia+coli+expressed+Plasmodium+falciparum+thrombospondin+related+apical+merozoite+protein+%28PTRAMP%29%2C+a+putative+malaria+vaccine+candidate&rft.au=Uchime%2C+Onyinyechukwu%3BReiter%2C+Karine%3BNguyen%2C+Vu%3BGlen%2C+Jacqueline%3BMiller%2C+Louis%3BNarum%2C+David%3BPlassmeyer%2C+Matthew&rft.aulast=Uchime&rft.aufirst=Onyinyechukwu&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early Innate Immune Events in the Skin after Transmission of Yersinia Pestis by Fleas T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834471; 5079747 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Bosio, Christopher AU - Jarrett, Clayton AU - Hinnebusch, B Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Skin KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Early+Innate+Immune+Events+in+the+Skin+after+Transmission+of+Yersinia+Pestis+by+Fleas&rft.au=Bosio%2C+Christopher%3BJarrett%2C+Clayton%3BHinnebusch%2C+B&rft.aulast=Bosio&rft.aufirst=Christopher&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tyrosine Nitration of Proteins by a Putative Nitrate Reductase in Sexual and Asexual P. Falciparum Parasites T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834175; 5079999 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ostera, Graciela AU - Ribeiro, Jose AU - Hume, Jennifer AU - Tokumasu, Fuyuki Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Nitrate reductase KW - Nitration KW - Tyrosine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Tyrosine+Nitration+of+Proteins+by+a+Putative+Nitrate+Reductase+in+Sexual+and+Asexual+P.+Falciparum+Parasites&rft.au=Ostera%2C+Graciela%3BRibeiro%2C+Jose%3BHume%2C+Jennifer%3BTokumasu%2C+Fuyuki&rft.aulast=Ostera&rft.aufirst=Graciela&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A longitudinal study of the acquisition and maintenance of Plasmodium falciparum-specific memory B cells T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41833621; 5079106 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Weiss, Greta AU - Traore, Boubacar AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Mircetic, Marko AU - Ongoiba, Aissata AU - Kayentao, Kassoum AU - Doumbo, Ogobara AU - Pierce, Susan AU - Crompton, Peter Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Longitudinal studies KW - Lymphocytes B KW - Memory cells KW - Immunological memory KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41833621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+longitudinal+study+of+the+acquisition+and+maintenance+of+Plasmodium+falciparum-specific+memory+B+cells&rft.au=Weiss%2C+Greta%3BTraore%2C+Boubacar%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BMircetic%2C+Marko%3BOngoiba%2C+Aissata%3BKayentao%2C+Kassoum%3BDoumbo%2C+Ogobara%3BPierce%2C+Susan%3BCrompton%2C+Peter&rft.aulast=Weiss&rft.aufirst=Greta&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression between Infective and Non -Infective Stage Strongyloides Stercoralis Larvae Revealed by Microarray T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41833595; 5080244 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ramanathan, Roshan AU - Abraham, David AU - Myers, Timothy AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Larvae KW - Gene expression KW - Strongyloides stercoralis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41833595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Differential+Gene+Expression+between+Infective+and+Non+-Infective+Stage+Strongyloides+Stercoralis+Larvae+Revealed+by+Microarray&rft.au=Ramanathan%2C+Roshan%3BAbraham%2C+David%3BMyers%2C+Timothy%3BNutman%2C+Thomas&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Diagnostics and Speciation Guide Choice of Alternative , Short-Course Treatment Regimens for Cutaneous Leishmaniasis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41829358; 5079334 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ramanathan, Roshan AU - Talaat, Kawsar AU - Fedorko, Daniel AU - Mahanty, Siddhartha AU - Nash, Theodore Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Speciation KW - Cutaneous leishmaniasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Molecular+Diagnostics+and+Speciation+Guide+Choice+of+Alternative+%2C+Short-Course+Treatment+Regimens+for+Cutaneous+Leishmaniasis&rft.au=Ramanathan%2C+Roshan%3BTalaat%2C+Kawsar%3BFedorko%2C+Daniel%3BMahanty%2C+Siddhartha%3BNash%2C+Theodore&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Navigating the Nationalational Institutes of Health system T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41829300; 5078816 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Costero, Adriana Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Navigating+the+Nationalational+Institutes+of+Health+system&rft.au=Costero%2C+Adriana&rft.aulast=Costero&rft.aufirst=Adriana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Stoichiometry of Antibody -Mediated Neutralization of West Nile Virus Infection : Factors That Govern Antibody Potency T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41827012; 5079352 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Nelson, Steevenson AU - Mehlhop, Erin AU - Jost, Christiane AU - Johnson, Syd AU - Fremont, Daved AU - Diamond, Michael AU - Pierson, Theodore Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Neutralization KW - Antibodies KW - West Nile virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41827012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+Stoichiometry+of+Antibody+-Mediated+Neutralization+of+West+Nile+Virus+Infection+%3A+Factors+That+Govern+Antibody+Potency&rft.au=Nelson%2C+Steevenson%3BMehlhop%2C+Erin%3BJost%2C+Christiane%3BJohnson%2C+Syd%3BFremont%2C+Daved%3BDiamond%2C+Michael%3BPierson%2C+Theodore&rft.aulast=Nelson&rft.aufirst=Steevenson&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How to Turn Potentiation to Protection : Impact of Immunity to Sand Fly Saliva on Leishmaniasis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41821928; 5080176 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Sand KW - Leishmaniasis KW - Immunity KW - Saliva KW - Potentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41821928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=How+to+Turn+Potentiation+to+Protection+%3A+Impact+of+Immunity+to+Sand+Fly+Saliva+on+Leishmaniasis&rft.au=Valenzuela%2C+Jesus&rft.aulast=Valenzuela&rft.aufirst=Jesus&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patent filarial infection modulates malaria -specific Type 1 cytokine responses in an IL-10 dependent manner in a filaria /malaria co -infected population T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41820354; 5080392 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Metenou, Simon AU - Dembele, Benoit AU - Konate, Siaka AU - Dolo, Housseini AU - Soumaoro, Lamine AU - Diallo, Abdallah AU - Coulibaly, Michel AU - Coulibaly, Siaka AU - Sanogo, Dramane AU - Coulibaly, Yaya AU - Traore, Sekou AU - Klion, Amy AU - Nutman, Thomas AU - Mahanty, Siddhartha Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Malaria KW - Infection KW - Patents KW - Interleukin 10 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41820354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Patent+filarial+infection+modulates+malaria+-specific+Type+1+cytokine+responses+in+an+IL-10+dependent+manner+in+a+filaria+%2Fmalaria+co+-infected+population&rft.au=Metenou%2C+Simon%3BDembele%2C+Benoit%3BKonate%2C+Siaka%3BDolo%2C+Housseini%3BSoumaoro%2C+Lamine%3BDiallo%2C+Abdallah%3BCoulibaly%2C+Michel%3BCoulibaly%2C+Siaka%3BSanogo%2C+Dramane%3BCoulibaly%2C+Yaya%3BTraore%2C+Sekou%3BKlion%2C+Amy%3BNutman%2C+Thomas%3BMahanty%2C+Siddhartha&rft.aulast=Metenou&rft.aufirst=Simon&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Age-Related Changes in Bone Marrow T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41980810; 5123272 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Longo, Dan Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Bone marrow KW - Reviews KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41980810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Overview+of+Age-Related+Changes+in+Bone+Marrow&rft.au=Longo%2C+Dan&rft.aulast=Longo&rft.aufirst=Dan&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of Acute Lymphoblastic Leukemia in Children and Adolescents: Peaks and Pitfalls T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41980532; 5123215 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Seibel, Nita Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Adolescents KW - Acute lymphatic leukemia KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41980532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Treatment+of+Acute+Lymphoblastic+Leukemia+in+Children+and+Adolescents%3A+Peaks+and+Pitfalls&rft.au=Seibel%2C+Nita&rft.aulast=Seibel&rft.aufirst=Nita&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mild Pro-Inflammatory State and Anemia in Older Persons T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41964691; 5123275 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Ferrucci, Luigi Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Anemia KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41964691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Mild+Pro-Inflammatory+State+and+Anemia+in+Older+Persons&rft.au=Ferrucci%2C+Luigi&rft.aulast=Ferrucci&rft.aufirst=Luigi&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Small-Molecule Therapeutics for Sickle Cell Disease: Nitric Oxide, Carbon Monoxide, Nitrite, and Apolipoprotein A T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41922479; 5123197 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Kato, Gregory Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Carbon monoxide KW - Nitrite KW - Nitric oxide KW - Apolipoprotein A KW - Sickle cell disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41922479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Novel+Small-Molecule+Therapeutics+for+Sickle+Cell+Disease%3A+Nitric+Oxide%2C+Carbon+Monoxide%2C+Nitrite%2C+and+Apolipoprotein+A&rft.au=Kato%2C+Gregory&rft.aulast=Kato&rft.aufirst=Gregory&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biology Lessons From Human Disease--the Pathophysiology of Bone Marrow Failure T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41902609; 5123114 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Young, Neal Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Bone marrow KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Biology+Lessons+From+Human+Disease--the+Pathophysiology+of+Bone+Marrow+Failure&rft.au=Young%2C+Neal&rft.aulast=Young&rft.aufirst=Neal&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insights on the "Oaks" of the Forest of Life T2 - 6th Annual Rocky Mountain Bioinformatics Conference (ROCKY 2008) AN - 41693291; 4999581 JF - 6th Annual Rocky Mountain Bioinformatics Conference (ROCKY 2008) AU - Puigbo, Pere Y1 - 2008/12/04/ PY - 2008 DA - 2008 Dec 04 KW - Forests KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41693291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28ROCKY+2008%29&rft.atitle=Insights+on+the+%22Oaks%22+of+the+Forest+of+Life&rft.au=Puigbo%2C+Pere&rft.aulast=Puigbo&rft.aufirst=Pere&rft.date=2008-12-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28ROCKY+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/cms_addon/conferences/rocky08/pdf/ProgramBookRocky 08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Obesity, Mammography Use and Accuracy, and Advanced Breast Cancer Risk AN - 20457905; 9145974 AB - Background Being overweight or obese is associated with increased breast cancer risk and disease severity among postmenopausal women, but whether extent of mammography use and accuracy modify this association and further contribute to increases in disease severity at diagnosis among overweight and obese women is unclear.Methods We prospectively collected data during 1996-2005 on 287115 postmenopausal women not using hormone therapy (HT) who underwent 614562 mammography examinations; 4446 women were diagnosed with breast cancer within 12 months of a mammography examination. We calculated rates per 1000 mammography examinations of large (>15 mm), advanced-stage (IIb, III, or IV), high-grade (3 or 4), estrogen receptor (ER)-positive and -negative, and screen-detected and non-screen-detected breast cancer across body mass index (BMI, kg/m2 ) groups defined as normal (18.5-24.9), overweight (25.0-29.9), obese class I (30.0-34.9), and obese class II/III ( greater than or equal to 35.0), adjusting for age, race/ethnicity, and mammography registry and use. All statistical tests were two-sided.Results Adjusted rates per 1000 mammography examinations of overall breast cancer increased across BMI groups (6.6 normal, 7.4 overweight, 7.9 obese I, 8.5 obese II/III; Ptrend < .001), as did rates of advanced disease, including large invasive (2.3 normal, 2.6 overweight, 2.9 obese I, 3.2 obese II/III; Ptrend < .001), advanced-stage (0.8 normal, 0.9 overweight, 1.3 obese I, 1.5 obese II/III; Ptrend < .001), and high nuclear grade (1.5 normal, 1.7 overweight, 1.7 obese I, 1.9 obese II/III; Ptrend = .10) tumors. Rates of ER-positive tumors increased across BMI groups (Ptrend < .001); rates of ER-negative tumors did not. Rates of screen-detected cancers were higher among overweight and obese women than normal and underweight women, but rates of non-screen-detected (false-negative) cancers were similar. Rates of advanced breast cancer increased across BMI groups regardless of extent of mammography use.Conclusions Patterns of mammography use and mammography accuracy are not the primary reasons for higher rates of advanced breast cancer among overweight and obese postmenopausal women not using HT; thus, biologic differences in breast tumor development and/or progression may be important. JF - Journal of the National Cancer Institute AU - Kerlikowske, Karla AU - Walker, Rod AU - Miglioretti, Diana L AU - Desai, Arati AU - Ballard-Barbash, Rachel AU - Buist, Diana SM AD - Affiliations of authors: Departments of Epidemiology and Biostatistics (KK) and General Internal Medicine Section, Department of Veterans Affairs, University of California, San Francisco, CA (KK); Group Health Center for Health Studies, Seattle, WA (RW, DLM, DSMB); Department of Biostatistics, University of Washington, Seattle, WA (DLM); Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (AD); Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD (RBB), karla.kerlikowske@ucsf.edu Y1 - 2008/12/03/ PY - 2008 DA - 2008 Dec 03 SP - 1724 EP - 1733 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 23 SN - 0027-8874, 0027-8874 KW - Physical Education Index; Risk Abstracts KW - Obesity KW - Age KW - Mammography KW - post-menopause KW - Body mass KW - Women KW - obesity KW - tumors KW - Breasts KW - Tumors KW - Hormones KW - Cancer KW - Evaluation KW - body mass KW - Breast cancer KW - Diseases KW - Ethnic groups KW - estrogens KW - PE 090:Sports Medicine & Exercise Sport Science KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20457905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Obesity%2C+Mammography+Use+and+Accuracy%2C+and+Advanced+Breast+Cancer+Risk&rft.au=Kerlikowske%2C+Karla%3BWalker%2C+Rod%3BMiglioretti%2C+Diana+L%3BDesai%2C+Arati%3BBallard-Barbash%2C+Rachel%3BBuist%2C+Diana+SM&rft.aulast=Kerlikowske&rft.aufirst=Karla&rft.date=2008-12-03&rft.volume=100&rft.issue=23&rft.spage=1724&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn388 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Mammography; Body mass; Women; Breasts; Diseases; Tumors; Cancer; Age; post-menopause; body mass; obesity; Breast cancer; tumors; Hormones; Ethnic groups; estrogens DO - http://dx.doi.org/10.1093/jnci/djn388 ER - TY - JOUR T1 - Fat, Protein, and Meat Consumption and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies AN - 20456720; 9145971 AB - Background Results of several case-control studies suggest that high consumption of meat (all meat, red meat, or processed meat) is associated with an increased risk of renal cell cancer, but only a few prospective studies have examined the associations of intakes of meat, fat, and protein with renal cell cancer.Methods We conducted a pooled analysis of 13 prospective studies that included 530469 women and 244483 men and had follow-up times of up to 7-20 years to examine associations between meat, fat, and protein intakes and the risk of renal cell cancer. All participants had completed a validated food frequency questionnaire at study entry. Using the primary data from each study, we calculated the study-specific relative risks (RRs) for renal cell cancer by using Cox proportional hazards models and then pooled these RRs by using a random-effects model. All statistical tests were two-sided.Results A total of 1478 incident cases of renal cell cancer were identified (709 in women and 769 in men). We observed statistically significant positive associations or trends in pooled age-adjusted models for intakes of total fat, saturated fat, monounsaturated fat, polyunsaturated fat, cholesterol, total protein, and animal protein. However, these associations were attenuated and no longer statistically significant after adjusting for body mass index, fruit and vegetable intake, and alcohol intake. For example, the pooled age-adjusted RR of renal cell cancer for the highest vs the lowest quintile of intake for total fat was 1.30 (95% confidence interval [CI] = 1.08 to 1.56; Ptrend = .001) and for total protein was 1.17 (95% CI = 0.99 to 1.38; Ptrend = .02). By comparison, the pooled multivariable RR for the highest vs the lowest quintile of total fat intake was 1.10 (95% CI = 0.92 to 1.32; Ptrend = .31) and of total protein intake was 1.06 (95% CI = 0.89 to 1.26; Ptrend = .37). Intakes of red meat, processed meat, poultry, or seafood were not associated with the risk of renal cell cancer.Conclusions Intakes of fat and protein or their subtypes, red meat, processed meat, poultry, and seafood are not associated with risk of renal cell cancer. JF - Journal of the National Cancer Institute AU - Lee, Jung Eun AU - Spiegelman, Donna AU - Hunter, David J AU - Albanes, Demetrius AU - Bernstein, Leslie AU - van den Brandt, Piet A AU - Buring, Julie E AU - Cho, Eunyoung AU - English, Dallas R AU - Freudenheim, Jo L AU - Giles, Graham G AU - Graham, Saxon AU - Horn-Ross, Pamela L AU - Haakansson, Niclas AU - Leitzmann, Michael F AU - Maennistoe, Satu AU - McCullough, Marjorie L AU - Miller, Anthony B AU - Parker, Alexander S AU - Rohan, Thomas E AU - Schatzkin, Arthur AU - Schouten, Leo J AU - Sweeney, Carol AU - Willett, Walter C AU - Wolk, Alicja AU - Zhang, Shumin M AU - Smith-Warner, Stephanie A AD - Affiliations of authors: Channing Laboratory (JEL, DJH, EC, WCW) and Division of Preventive Medicine (JEB, SMZ), Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA; Department of Epidemiology (DS, DJH, JEB, WCW, SASW), Department of Nutrition (DJH, WCW, SASW), and Department of Biostatistics (DS), Harvard School of Public Health, Boston, MA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Health Services, Bethesda, MD (DA, MFL, AS); City of Hope Comprehensive Cancer Center and Beckman Research Institute, City of Hope National Medical Center, Duarte, CA (LB); Department of Epidemiology, GROW-School for Oncology and Developmental Biology, University Maastricht, Maastricht, The Netherlands (PAvdB, LJS); Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia (DRE, GGG); Department of Social and Preventive Medicine, University at Buffalo, State U, jung.lee@channing.harvard.edu Y1 - 2008/12/03/ PY - 2008 DA - 2008 Dec 03 SP - 1695 EP - 1706 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 23 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Alcohol KW - poultry KW - body mass KW - fruits KW - Proteins KW - Seafood KW - cholesterol KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20456720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Fat%2C+Protein%2C+and+Meat+Consumption+and+Renal+Cell+Cancer+Risk%3A+A+Pooled+Analysis+of+13+Prospective+Studies&rft.au=Lee%2C+Jung+Eun%3BSpiegelman%2C+Donna%3BHunter%2C+David+J%3BAlbanes%2C+Demetrius%3BBernstein%2C+Leslie%3Bvan+den+Brandt%2C+Piet+A%3BBuring%2C+Julie+E%3BCho%2C+Eunyoung%3BEnglish%2C+Dallas+R%3BFreudenheim%2C+Jo+L%3BGiles%2C+Graham+G%3BGraham%2C+Saxon%3BHorn-Ross%2C+Pamela+L%3BHaakansson%2C+Niclas%3BLeitzmann%2C+Michael+F%3BMaennistoe%2C+Satu%3BMcCullough%2C+Marjorie+L%3BMiller%2C+Anthony+B%3BParker%2C+Alexander+S%3BRohan%2C+Thomas+E%3BSchatzkin%2C+Arthur%3BSchouten%2C+Leo+J%3BSweeney%2C+Carol%3BWillett%2C+Walter+C%3BWolk%2C+Alicja%3BZhang%2C+Shumin+M%3BSmith-Warner%2C+Stephanie+A&rft.aulast=Lee&rft.aufirst=Jung&rft.date=2008-12-03&rft.volume=100&rft.issue=23&rft.spage=1695&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn386 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Alcohol; poultry; body mass; fruits; Proteins; Seafood; cholesterol; Cancer DO - http://dx.doi.org/10.1093/jnci/djn386 ER - TY - JOUR T1 - Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users. AN - 69827185; 19034286 AB - Domestic fuel combustion from cooking and heating, to which about 3 billion people worldwide are exposed, is associated with increased lung cancer risk. Lung cancer incidence in Xuanwei is the highest in China, and the attributable risk of lung cancer from unvented smoky coal burning is greater than 90%. To evaluate any lung cancer mortality reduction after changing from unvented stoves to portable stoves, we used lifetime smoky coal users in a retrospective cohort of all farmers born during 1917-1951 and residing in Xuanwei in 1976. Of the 42,422 enrolled farmers, 4054 lifetime smoky coal users changed to portable stoves, 4364 did not change, and 1074 died of lung cancer. Lung cancer morality associated with stove change was assessed by product-limit survival curves and multivariate Cox regression models. Both men (P<0.0001) and women (P<0.0001) who changed to portable stoves had a significantly increased probability of survival compared with those who did not change. Portable stoves were associated with decreased risk of lung cancer mortality in male participants (hazard ratio (HR)=0.62, 95% confidence interval (CI)=0.46-0.82) and female participants (HR=0.41, 95% CI=0.29-0.57). Portable stove use is associated with reduced lung cancer mortality risk, highlighting a cost-effective intervention that could substantially benefit health in developing countries. JF - British journal of cancer AU - Hosgood, H D AU - Chapman, R AU - Shen, M AU - Blair, A AU - Chen, E AU - Zheng, T AU - Lee, K-M AU - He, X AU - Lan, Q AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7240, USA. hosgoodd@mail.nih.gov Y1 - 2008/12/02/ PY - 2008 DA - 2008 Dec 02 SP - 1934 EP - 1939 VL - 99 IS - 11 KW - Coal KW - 0 KW - Smoke KW - Index Medicus KW - Ventilation KW - Humans KW - China -- epidemiology KW - Surveys and Questionnaires KW - Retrospective Studies KW - Male KW - Female KW - Proportional Hazards Models KW - Smoke -- adverse effects KW - Air Pollution, Indoor -- adverse effects KW - Lung Neoplasms -- etiology KW - Coal -- adverse effects KW - Cooking -- methods KW - Lung Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69827185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Portable+stove+use+is+associated+with+lower+lung+cancer+mortality+risk+in+lifetime+smoky+coal+users.&rft.au=Hosgood%2C+H+D%3BChapman%2C+R%3BShen%2C+M%3BBlair%2C+A%3BChen%2C+E%3BZheng%2C+T%3BLee%2C+K-M%3BHe%2C+X%3BLan%2C+Q&rft.aulast=Hosgood&rft.aufirst=H&rft.date=2008-12-02&rft.volume=99&rft.issue=11&rft.spage=1934&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fsj.bjc.6604744 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-30 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Indoor Air. 2000 Sep;10(3):200-5 [10979201] Am J Epidemiol. 2007 Jun 1;165(11):1280-6 [17369610] Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Jun;23(3):186-9 [12411086] Toxicology. 2004 May 20;198(1-3):301-5 [15138056] Health Educ Res. 2004 Oct;19(5):543-50 [15199008] Science. 1987 Jan 9;235(4785):217-20 [3798109] Arch Environ Health. 1988 Mar-Apr;43(2):180-5 [3377554] J Natl Cancer Inst. 1989 Dec 6;81(23):1800-6 [2555531] IARC Sci Publ. 1991;(105):460-5 [1855896] Carcinogenesis. 1995 Dec;16(12):3031-6 [8603481] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Br J Cancer. 2005 Oct 3;93(7):825-33 [16160696] BMJ. 2005 Nov 5;331(7524):1050 [16234255] Soc Sci Med. 2006 Jun;62(12):3161-76 [16426715] Int J Hyg Environ Health. 2006 Sep;209(5):445-50 [16765087] J Epidemiol Community Health. 2007 Jan;61(1):74-9 [17183019] Lancet Oncol. 2006 Dec;7(12):977-8 [17348122] J Natl Cancer Inst. 2002 Jun 5;94(11):826-35 [12048270] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.bjc.6604744 ER - TY - JOUR T1 - Breast cancer incidence following low-dose rate environmental exposure: Techa River Cohort, 1956-2004. AN - 69824240; 19002173 AB - In the 1950s, the Mayak nuclear weapons facility in Russia discharged liquid radioactive wastes into the Techa River causing exposure of riverside residents to protracted low-to-moderate doses of radiation. Almost 10,000 women received estimated doses to the stomach of up to 0.47 Gray (Gy) (mean dose=0.04 Gy) from external gamma-exposure and (137)Cs incorporation. We have been following this population for cancer incidence and mortality and as in the general Russian population, we found a significant temporal trend of breast cancer incidence. A significant linear radiation dose-response relationship was observed (P=0.01) with an estimated excess relative risk per Gray (ERR/Gy) of 5.00 (95% confidence interval (CI), 0.80, 12.76). We estimated that approximately 12% of the 109 observed cases could be attributed to radiation. JF - British journal of cancer AU - Ostroumova, E AU - Preston, D L AU - Ron, E AU - Krestinina, L AU - Davis, F G AU - Kossenko, M AU - Akleyev, A AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MS 7238, 6120 Executive Boulevard, Bethesda, MD 20892-7238, USA. zhenia@urcrm.chel.su Y1 - 2008/12/02/ PY - 2008 DA - 2008 Dec 02 SP - 1940 EP - 1945 VL - 99 IS - 11 KW - Index Medicus KW - Humans KW - Incidence KW - Russia KW - Dose-Response Relationship, Radiation KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Radioactive Hazard Release KW - Neoplasms, Radiation-Induced -- epidemiology KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69824240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Breast+cancer+incidence+following+low-dose+rate+environmental+exposure%3A+Techa+River+Cohort%2C+1956-2004.&rft.au=Ostroumova%2C+E%3BPreston%2C+D+L%3BRon%2C+E%3BKrestinina%2C+L%3BDavis%2C+F+G%3BKossenko%2C+M%3BAkleyev%2C+A&rft.aulast=Ostroumova&rft.aufirst=E&rft.date=2008-12-02&rft.volume=99&rft.issue=11&rft.spage=1940&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fsj.bjc.6604775 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-30 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1984 Jul 15;34(1):71-5 [6746122] Vopr Onkol. 1982;28(10):26-71 [7147820] Int J Epidemiol. 1989 Sep;18(3):498-510 [2807650] Radiat Res. 1991 Feb;125(2):214-22 [1996380] Cancer Causes Control. 1990 Jul;1(1):39-49 [2102275] Vopr Onkol. 1991;37(4):401-36 [1887640] J Natl Cancer Inst. 1993 Oct 20;85(20):1679-85 [8411245] Vopr Onkol. 1992;38(12):1413-83 [1343179] Sci Total Environ. 1994 Mar 1;142(1-2):1-8 [8178126] Sci Total Environ. 1994 Mar 1;142(1-2):49-61 [8178136] Radiat Res. 1999 May;151(5):626-32 [10319736] Radiat Res. 2005 Oct;164(4 Pt 1):409-19 [16187743] Radiat Res. 2005 Nov;164(5):591-601 [16238436] Radiat Res. 2005 Nov;164(5):602-11 [16238437] Int J Cancer. 2006 Aug 1;119(3):651-8 [16506213] J Travel Med. 2006 May-Jun;13(3):127-32 [16706942] Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Radiat Res. 2006 Jul;166(1 Pt 2):255-70 [16808612] Radiat Res. 2007 Jul;168(1):1-64 [17722996] Int J Epidemiol. 2007 Oct;36(5):1038-46 [17768163] Health Phys. 2000 May;78(5):542-54 [10772028] Health Phys. 2000 Jul;79(1):24-35 [10855775] Spine (Phila Pa 1976). 2000 Aug 15;25(16):2052-63 [10954636] Cancer Causes Control. 2001 Feb;12(2):95-101 [11246849] Health Phys. 2002 Apr;82(4):455-66 [11906134] Radiat Res. 2002 Aug;158(2):220-35 [12105993] Radiat Environ Biophys. 2003 Oct;42(3):169-74 [14579133] Radiat Res. 2003 Dec;160(6):707-17 [14640793] Vopr Onkol. 1975;21(1):3-16 [163550] N Engl J Med. 1989 Nov 9;321(19):1281-4 [2797100] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.bjc.6604775 ER - TY - JOUR T1 - Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry AN - 883023686; 15305944 AB - The HIV-1 co-receptor CCR5 possesses sulfo-tyrosine (TYS) residues at its N-terminus (Nt) that are required for binding HIV-1 gp120 and mediating viral entry. By using a 14-residue fragment of CCR5 Nt containing two TYS residues, we recently showed that CCR5 Nt binds gp120 through a conserved region specific for TYS moieties and suggested that this site may represent a target for inhibitors and probes of HIV-1 entry. As peptides containing sulfo-tyrosines are difficult to synthesize and handle due to limited stability of the sulfo-ester moiety, we have now incorporated TYS isosteres into CCR5 Nt analogs and assessed their binding to a complex of gp120-CD4 using saturation transfer difference (STD) NMR and surface plasmon resonance (SPR). STD enhancements for CCR5 Nt peptides containing tyrosine sulfonate (TYSN) in complex with gp120-CD4 were very similar to those observed for sulfated CCR5 Nt peptides indicating comparable modes of binding. STD enhancements for phosphotyrosine-containing CCR5 Nt analogs were greatly diminished consistent with earlier findings showing sulfo-tyrosine to be essential for CCR5 Nt binding to gp120. Tyrosine sulfonate-containing CCR5 peptides exhibited reduced water solubility, limiting their use in assay and probe development. To improve solubility, we designed, synthesized, and incorporated in CCR5 Nt peptide analogs an orthogonally functionalized azido tris(ethylenoxy) l-alanine (l-ate-Ala) residue. Through NMR and SPR experiments, we show a 19-residue TYSN-containing peptide to be a functional, hydrolytically stable CCR5 Nt isostere that was in turn used to develop both SPR-based and ELISA assays to screen for inhibitors of CCR5 binding to gp120-CD4. JF - Bioorganic and Medicinal Chemistry AU - Lam, Son N AU - Acharya, Priyamvada AU - Wyatt, Richard AU - Kwong, Peter D AU - Bewley, Carole A Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 10113 EP - 10120 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 16 IS - 23 SN - 0968-0896, 0968-0896 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - CCR5 protein KW - Development KW - Enzyme-linked immunosorbent assay KW - Glycoprotein gp120 KW - L-Alanine KW - N-Terminus KW - N.M.R. KW - Probes KW - Solubility KW - Tyrosine KW - surface plasmon resonance KW - Human immunodeficiency virus 1 KW - V 22360:AIDS and HIV KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883023686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Tyrosine-sulfate+isosteres+of+CCR5+N-terminus+as+tools+for+studying+HIV-1+entry&rft.au=Lam%2C+Son+N%3BAcharya%2C+Priyamvada%3BWyatt%2C+Richard%3BKwong%2C+Peter+D%3BBewley%2C+Carole+A&rft.aulast=Lam&rft.aufirst=Son&rft.date=2008-12-01&rft.volume=16&rft.issue=23&rft.spage=10113&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-02-22 N1 - SubjectsTermNotLitGenreText - Glycoprotein gp120; Enzyme-linked immunosorbent assay; surface plasmon resonance; Solubility; L-Alanine; Probes; Tyrosine; N.M.R.; CCR5 protein; Development; N-Terminus; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bmc.2008.10.005 ER - TY - JOUR T1 - Literacy-Based Normative Data For Low Socioeconomic Status African Americans AN - 85692413; 200906967 AB - Clinical neuropsychology relies on the use of appropriate test norms. Normative studies frequently stratify based on age, education, sex, and race. None to date has reported norms based on literacy, despite the substantial evidence that literacy impacts cognitive functioning. Some researchers have suggested that literacy is a more accurate reflection of academic achievement and quality of education than years of education, particularly for African Americans. The current study provides literacy-based normative data for multiple neuropsychological measures based on a sample of predominantly low socioeconomic status African Americans. These normative data should improve the diagnostic accuracy of performances by African-American clients with similar demographic backgrounds. Adapted from the source document JF - The Clinical Neuropsychologist AU - Dotson, Vonetta M AU - Kitner-Triolo, Melissa AU - Evans, Michele K AU - Zonderman, Alan B AD - National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Dr., Baltimore, MD 21224, USA dotsonv@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 989 EP - 1017 VL - 22 IS - 6 SN - 1385-4046, 1385-4046 KW - Literacy (48550) KW - Diagnostic Tests (18550) KW - Black Americans (09100) KW - Socioeconomic Status (80150) KW - Academic Achievement (00070) KW - Test Validity and Reliability (88800) KW - Neuropsychological Assessment (57285) KW - article KW - 4115: applied linguistics; adult language development/literacy studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85692413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=Literacy-Based+Normative+Data+For+Low+Socioeconomic+Status+African+Americans&rft.au=Dotson%2C+Vonetta+M%3BKitner-Triolo%2C+Melissa%3BEvans%2C+Michele+K%3BZonderman%2C+Alan+B&rft.aulast=Dotson&rft.aufirst=Vonetta&rft.date=2008-12-01&rft.volume=22&rft.issue=6&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Literacy (48550); Socioeconomic Status (80150); Test Validity and Reliability (88800); Black Americans (09100); Academic Achievement (00070); Neuropsychological Assessment (57285); Diagnostic Tests (18550) ER - TY - JOUR T1 - Introduction to the Special Section: Transformative Research on Emotion Regulation and Dysregulation AN - 839605670; 201100972 AB - Scholars are giving increased attention to the need to incorporate research on more basic developmental processes into new paradigms for understanding and treating mental illness in children and adolescents. The study of emotion regulation, rooted in neurodevelopment, has proven a fruitful model for understanding and characterizing problems of behavior and risk in children and adolescents. This article summarizes NIMH initiatives designed to encourage transformational research on the neurodevelopment origins of mental illness. It highlights the NIMH Strategic Plan and the Report on Transformative Neurodevelopment Research as part of an introduction to a collection of articles that grew out of a previously organized NIMH workshop on developmental and translational models of emotion regulation and dysregulation. Adapted from the source document. JF - Child Development Perspectives AU - Delcarmen-Wiggins, Rebecca Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 121 EP - 123 PB - Wiley Publishing, Malden, MA 02148 VL - 2 IS - 3 SN - 1750-8592, 1750-8592 KW - emotion regulation KW - neurodevelopment KW - translational models KW - transformational research KW - Workshops KW - Mental illness KW - Developmental processes KW - Emotional regulation KW - Children KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839605670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development+Perspectives&rft.atitle=Introduction+to+the+Special+Section%3A+Transformative+Research+on+Emotion+Regulation+and+Dysregulation&rft.au=Delcarmen-Wiggins%2C+Rebecca&rft.aulast=Delcarmen-Wiggins&rft.aufirst=Rebecca&rft.date=2008-12-01&rft.volume=2&rft.issue=3&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Child+Development+Perspectives&rft.issn=17508592&rft_id=info:doi/10.1111%2Fj.1750-8606.2008.00053.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Emotional regulation; Mental illness; Adolescents; Children; Workshops; Developmental processes DO - http://dx.doi.org/10.1111/j.1750-8606.2008.00053.x ER - TY - JOUR T1 - Fetal alcohol spectrum disorder. AN - 69943829; 19129565 AB - Maternal alcohol use during pregnancy leads to fetal alcohol spectrum disorder (FASD) in their children. FASD is characterized by typical facial features, growth retardation, intellectual dysfunction and behavioral problems. Alcohol is neurotoxic to the brain during the developmental stage. Behavioral problems in children with FASD start at an early age and progress to adulthood. It is an important preventable cause of intellectual dysfunction and behavioral problems. This article reviews current prevalence, clinical features, pathogenesis and differential diagnosis of FASD. It also highlights the need for physicians to be aware of this condition. Articles were searched on the internet using fetal alcohol syndrome, fetal alcohol spectrum disorders, women and alcohol. Following links were used to locate journals; EBSCO, OVID, Science Direct, PubMed and NIAAA. Alcohol consumption during pregnancy can lead to a spectrum of deficits. Though physical features are essential to make the diagnosis of FAS, it is important to note that neurocognitive and behavioural deficits can be present in the absence of physical features (alcohol related neurodevelopmental disorder or ARND). Because there is no known safe amount of alcohol consumption during pregnancy, abstinence from alcohol for women who are pregnant or planning a pregnancy must be strongly advised. JF - Indian pediatrics AU - Nayak, Raghavendra Bheemappa AU - Murthy, Pratima AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 29, India. rbn.psych@gmail.com Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 977 EP - 983 VL - 45 IS - 12 SN - 0019-6061, 0019-6061 KW - Index Medicus KW - India -- epidemiology KW - Risk Factors KW - Humans KW - Female KW - Prevalence KW - Pregnancy KW - Maternal Behavior KW - Risk-Taking KW - Alcohol Drinking -- adverse effects KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Fetal Alcohol Spectrum Disorders -- etiology KW - Fetal Alcohol Spectrum Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69943829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+pediatrics&rft.atitle=Fetal+alcohol+spectrum+disorder.&rft.au=Nayak%2C+Raghavendra+Bheemappa%3BMurthy%2C+Pratima&rft.aulast=Nayak&rft.aufirst=Raghavendra&rft.date=2008-12-01&rft.volume=45&rft.issue=12&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Indian+pediatrics&rft.issn=00196061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2009-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques. AN - 69940862; 18978308 AB - Chemical exposures are important risks for development of hepatocellular carcinoma (HCC). One such chemical, diethylnitrosamine (DENA), is present in food products as well as in industrial and research settings. Further examination of tumors induced by DENA may yield clues to human risk. HCC from seven rhesus macaques exposed to DENA was selected from a tissue archive to examine for evidence of Wnt/beta-catenin signaling events, which are frequently associated with HCC. DENA exposure durations ranged from 8 to 207 months, and total accumulated dose ranged from 0.7 to 4.08 mg. Unexposed colony breeder macaques served as controls. Previously unrecognized HCC metastases were discovered in lungs of three macaques. Overexpression of beta-catenin and glutamine synthetase was detected by immunohistochemistry in six confirmed primary HCC and all metastatic HCC, which implicated Wnt/beta-catenin activation. Concomitant beta-catenin gene mutation was detected in one primary HCC; similar findings have been reported in human and rodent HCC. Neither beta-catenin mutation nor beta-catenin overexpression appeared to influence metastatic potential. Accumulation of intracellular proteins involved in Wnt/beta-catenin signaling during HCC oncogenesis in rhesus macaques exposed to DENA appears to include other mechanisms, in addition to mutation of beta-catenin gene. JF - Toxicologic pathology AU - Wei, Bih-Rong AU - Edwards, Jennifer B AU - Hoover, Shelley B AU - Tillman, Heather S AU - Reed, L Tiffany AU - Sills, Robert C AU - Simpson, R Mark AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 972 EP - 980 VL - 36 IS - 7 KW - Carcinogens KW - 0 KW - beta Catenin KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Glutamate-Ammonia Ligase KW - EC 6.3.1.2 KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Glutamate-Ammonia Ligase -- metabolism KW - Carcinogens -- toxicity KW - Carcinogenicity Tests KW - Macaca mulatta KW - Sequence Analysis, DNA KW - Tissue Banks KW - Immunohistochemistry KW - Diethylnitrosamine -- toxicity KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - beta Catenin -- metabolism KW - Liver Neoplasms -- chemically induced KW - beta Catenin -- genetics KW - Carcinoma, Hepatocellular -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69940862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Altered+%7Bbeta%7D-catenin+accumulation+in+hepatocellular+carcinomas+of+diethylnitrosamine-exposed+rhesus+macaques.&rft.au=Wei%2C+Bih-Rong%3BEdwards%2C+Jennifer+B%3BHoover%2C+Shelley+B%3BTillman%2C+Heather+S%3BReed%2C+L+Tiffany%3BSills%2C+Robert+C%3BSimpson%2C+R+Mark&rft.aulast=Wei&rft.aufirst=Bih-Rong&rft.date=2008-12-01&rft.volume=36&rft.issue=7&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308327120 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-06 N1 - Date created - 2009-01-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 1999 Nov 11;18(47):6583-8 [10597262] J Hepatol. 2008 May;48(5):884-6 [18314218] Eur J Cancer. 2001 Oct;37 Suppl 8:S4-66 [11602373] Oncogene. 2001 Nov 22;20(53):7812-6 [11753661] Cancer. 2002 Feb 25;96(1):49-52 [11836703] Biochim Biophys Acta. 2003 Jun 5;1653(1):1-24 [12781368] Gastroenterology. 2004 May;126(5):1374-86 [15131798] Carcinogenesis. 2004 Jun;25(6):901-8 [14742323] IARC Monogr Eval Carcinog Risk Chem Man. 1978 May;17:1-349 [150392] Cancer Res. 1983 Sep;43(9):4253-9 [6871863] Cancer Res. 1992 Sep 15;52(18):5042-5 [1516060] Regul Toxicol Pharmacol. 1994 Apr;19(2):130-51 [8041912] Cancer Res. 1998 Jun 15;58(12):2524-7 [9635572] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8847-51 [9671767] Cancer Res. 1999 Apr 15;59(8):1830-3 [10213486] Am J Pathol. 1999 Sep;155(3):703-10 [10487827] Semin Liver Dis. 1999;19(3):271-85 [10518307] Toxicol Pathol. 2005;33(1):175-80 [15805069] J Hepatol. 2005 Jun;42(6):842-9 [15885355] Semin Liver Dis. 2005;25(2):212-25 [15918149] Exp Mol Med. 2006 Feb 28;38(1):1-10 [16520547] Prostate. 2006 May 1;66(6):567-77 [16372335] Oncogene. 2006 Jun 26;25(27):3778-86 [16799619] Oncogene. 2006 Jun 26;25(27):3787-800 [16799620] Oncogene. 2007 Feb 1;26(5):774-80 [16964294] Hepatology. 2007 May;45(5):1298-305 [17464972] J Pathol. 2007 Jul;212(3):345-52 [17487939] Clin Cancer Res. 2007 Jul 15;13(14):4042-5 [17634527] Physiology (Bethesda). 2007 Oct;22:303-9 [17928543] J Gastroenterol Hepatol. 2008 Jan;23(1):110-8 [18171349] Cancer Res. 2001 Mar 1;61(5):2085-91 [11280770] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308327120 ER - TY - JOUR T1 - Vasopressin does not mediate hypersensitivity of the hypothalamic pituitary adrenal axis during chronic stress. AN - 69934617; 19120128 AB - The hypothesis that vasopressin (VP) becomes the main mediator of pituitary corticotroph responsiveness during chronic hypothalamic pituitary adrenal (HPA) axis activation was tested by examining the effect of pharmacologic VP receptor blockade on the adrenocorticotropic hormone (ACTH) and corticosterone responses of 14-day repeatedly restrained rats. In spite of the increased vasopressinergic activity, repeatedly restrained rats showed lower ACTH and corticosterone responses to 10 min white noise compared with handled controls. These responses were unchanged by injection of the nonpeptide-selective V1b receptor antagonist SSR149415 i.v., 1 h before noise application. In contrast to noise stress, plasma ACTH responses to i.p. hypertonic saline injection were enhanced in the repeatedly restrained rats compared with handled controls, but responses were also unaffected by SSR149415 administered orally, daily 1 h before restraint. Since SSR149415 effectiveness was low, we used minipump infusion of the peptide V1 receptor antagonist, dGly[Phaa1,D-tyr(et), Lys, Arg]VP (V1-Ant) for 14 days, which effectively blocked ACTH responses to exogenous VP. Chronic V1-Ant infusion reduced plasma ACTH responses to i.p. hypertonic saline in handled controls but not in repeatedly restrained rats. These data suggest that the increased vasopressinergic activity characteristic of chronic stress plays roles other than mediating the hypersensitivity of the HPA axis to a novel stress. JF - Annals of the New York Academy of Sciences AU - Chen, Jun AU - Young, Sharla AU - Subburaju, Sivan AU - Sheppard, Jack AU - Kiss, Alexander AU - Atkinson, Helen AU - Wood, Susan AU - Lightman, Stafford AU - Serradeil-Le Gal, Claudine AU - Aguilera, Greti AD - Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 349 EP - 359 VL - 1148 KW - 1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide KW - 0 KW - Antidiuretic Hormone Receptor Antagonists KW - Indoles KW - Pyrrolidines KW - Receptors, Vasopressin KW - Vasopressins KW - 11000-17-2 KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Receptors, Vasopressin -- metabolism KW - Drinking KW - Animals KW - Restraint, Physical KW - Humans KW - Pyrrolidines -- metabolism KW - Rats KW - Body Weight KW - Eating KW - Rats, Sprague-Dawley KW - Corticosterone -- blood KW - Noise KW - Indoles -- metabolism KW - Male KW - Adrenocorticotropic Hormone -- blood KW - Hypothalamo-Hypophyseal System -- physiology KW - Vasopressins -- metabolism KW - Stress, Psychological KW - Pituitary-Adrenal System -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69934617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Vasopressin+does+not+mediate+hypersensitivity+of+the+hypothalamic+pituitary+adrenal+axis+during+chronic+stress.&rft.au=Chen%2C+Jun%3BYoung%2C+Sharla%3BSubburaju%2C+Sivan%3BSheppard%2C+Jack%3BKiss%2C+Alexander%3BAtkinson%2C+Helen%3BWood%2C+Susan%3BLightman%2C+Stafford%3BSerradeil-Le+Gal%2C+Claudine%3BAguilera%2C+Greti&rft.aulast=Chen&rft.aufirst=Jun&rft.date=2008-12-01&rft.volume=1148&rft.issue=&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1410.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1990 Nov 5;532(1-2):34-40 [2178035] Endocrinology. 1989 Jul;125(1):28-34 [2544403] Neuroendocrinology. 1991 Dec;54(6):635-8 [1664502] J Endocrinol. 1992 Sep;134(3):327-39 [1402543] Endocrinology. 1993 Jan;132(1):241-8 [8380375] Front Neuroendocrinol. 1993 Apr;14(2):76-122 [8387436] Front Neuroendocrinol. 1994 Dec;15(4):321-50 [7895891] Br J Pharmacol. 1995 Nov;116(5):2417-24 [8581278] Endocrinology. 1997 Oct;138(10):4351-7 [9322950] Endocrinology. 1998 Feb;139(2):443-50 [9449609] Brain Res Mol Brain Res. 1999 May 7;68(1-2):129-40 [10320790] Endocrinology. 1999 Aug;140(8):3623-32 [10433220] Proc Soc Exp Biol Med. 1954 Nov;87(2):318-24 [13237230] CNS Drug Rev. 2005 Spring;11(1):53-68 [15867952] Endocrinology. 2007 Feb;148(2):849-56 [17122081] J Neuroendocrinol. 2007 Mar;19(3):189-97 [17280592] J Neuroendocrinol. 2007 Jul;19(7):543-51 [17561882] Endocrinology. 2007 Jul;148(7):3102-10 [17412807] Peptides. 1990 Jan-Feb;11(1):59-63 [2160653] Neuroscience. 1999;94(3):797-802 [10579570] Regul Pept. 2000 Dec 22;96(1-2):23-9 [11102648] J Neuroendocrinol. 2001 Aug;13(8):711-23 [11489088] J Pharmacol Exp Ther. 2002 Mar;300(3):1122-30 [11861823] J Clin Invest. 2004 Jan;113(2):302-9 [14722621] Physiol Behav. 2004 Jun;81(4):557-68 [15178148] Brain Res Bull. 2004 Jul 15;63(6):521-30 [15249118] Nature. 1982 Sep 23;299(5881):355-7 [6287293] Proc Natl Acad Sci U S A. 1984 Mar;81(6):1883-7 [6369332] J Biol Chem. 1987 Jan 25;262(3):1129-36 [2433273] Endocrinology. 1988 Jul;123(1):396-405 [2838259] Endocrinology. 1989 Jun;124(6):3102-8 [2542009] Neuroendocrinology. 1991 Feb;53(2):150-9 [1849619] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1410.037 ER - TY - JOUR T1 - Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders. AN - 69934385; 18828796 AB - Existing studies of the association between age at first drink (AFD) and the risk of alcohol use disorders (AUD) suffer from inconsistent levels of control and designs that may inflate associations by failure to control for duration of exposure to risk. This study examined associations between AFD (ages <15 and 15-17 vs. 18+ years) and first incidence of DSM-IV alcohol dependence, abuse, and specific AUD criteria over a 3-year follow-up in a longitudinal study of U.S. drinkers 18 years of age and older at baseline (n = 22,316), controlling for duration of exposure, family history, and a wide range of baseline and childhood risk factors. After adjusting for all risk factors, the incidence of dependence was increased for AFD <15 years (OR = 1.38) and for women only with AFD at ages 15 to 17 (OR = 1.54). The incidence of abuse was increased at AFD <15 and 15 to 17 years (OR = 1.52 and 1.30, respectively). Most dependence criteria showed significant associations with AFD, but hazardous drinking and continued drinking despite interpersonal problems were the only abuse criteria to do so. All associations were nonsignificant after controlling for volume of consumption, except that AFD at all ages <18 combined was associated with a reduced likelihood of impaired control, and AFD at ages 15 to 17 was associated with lower odds of drinking more/longer than intended among heavy-volume drinkers. In a population of low-risk drinkers that excluded those with positive family histories, personality disorders, and childhood risk factors, there were strong associations between early AFD (<18) and the incidence of dependence (OR = 3.79) and continued drinking despite physical/psychological problems (OR = 2.71), but no association with incidence of abuse. There is a robust association between AFD and the risk of AUD that appears to reflect willful rather than uncontrolled heavy drinking, consistent with misuse governed by poor decision-making and/or reward-processing skills associated with impaired executive cognitive function (ECF). Additional research is needed to determine causality in the role of impaired ECF, including longitudinal studies with samples of low-risk adolescents. JF - Alcoholism, clinical and experimental research AU - Dawson, Deborah A AU - Goldstein, Risë B AU - Chou, S Patricia AU - Ruan, W June AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9304, USA. ddawson@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2149 EP - 2160 VL - 32 IS - 12 KW - Index Medicus KW - Young Adult KW - Age Factors KW - Risk Factors KW - Humans KW - Incidence KW - Follow-Up Studies KW - Longitudinal Studies KW - Adolescent KW - Male KW - Female KW - Alcohol-Related Disorders -- diagnosis KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- epidemiology KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcohol-Related Disorders -- psychology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69934385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Age+at+first+drink+and+the+first+incidence+of+adult-onset+DSM-IV+alcohol+use+disorders.&rft.au=Dawson%2C+Deborah+A%3BGoldstein%2C+Ris%C3%AB+B%3BChou%2C+S+Patricia%3BRuan%2C+W+June%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2008-12-01&rft.volume=32&rft.issue=12&rft.spage=2149&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/10.1111%2Fj.1530-0277.2008.00806.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-09 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Psychiatry. 1990 Nov;147(11):1537-41 [2221170] Mol Psychiatry. 2009 Nov;14(11):1051-66 [18427559] Addiction. 1999 Jun;94(6):843-55 [10665074] Am J Psychiatry. 2000 May;157(5):745-50 [10784467] Biol Psychiatry. 2000 Aug 15;48(4):265-75 [10960157] Am J Psychiatry. 2001 Jul;158(7):1084-90 [11431230] Alcohol Clin Exp Res. 2001 Aug;25(8):1156-65 [11505047] Alcohol Clin Exp Res. 2001 Aug;25(8):1166-73 [11515563] J Subst Abuse. 2001;13(4):493-504 [11775078] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Subst Use Misuse. 2003 Dec;38(14):1983-2016 [14677779] Alcohol Clin Exp Res. 2004 Sep;28(9):1379-87 [15365309] J Pers Soc Psychol. 1986 Dec;51(6):1173-82 [3806354] Am J Psychiatry. 1991 Nov;148(11):1501-4 [1928463] J Pers Soc Psychol. 1991 Oct;61(4):614-28 [1960653] Br J Addict. 1992 Aug;87(8):1199-204 [1511233] Addiction. 1993 Aug;88(8):1079-90 [8401162] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Alcohol Clin Exp Res. 1995 Aug;19(4):1018-23 [7485811] J Stud Alcohol. 1997 Jul;58(4):397-404 [9203121] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] J Subst Abuse. 1997;9:103-10 [9494942] J Stud Alcohol. 1998 Jan;59(1):32-42 [9498313] Recent Dev Alcohol. 1998;14:227-51 [9751948] Addiction. 1998 Oct;93(10):1511-20 [9926555] Alcohol Clin Exp Res. 1999 Jan;23(1):101-7 [10029209] Am J Addict. 1999 Summer;8(3):190-200 [10506900] Alcohol Health Res World. 1998;22(2):144-7 [15706789] Addiction. 2005 May;100(5):652-61 [15847623] Alcohol Clin Exp Res. 2005 Oct;29(10):1869-76 [16269917] Behav Genet. 2006 Mar;36(2):195-200 [16402286] Arch Pediatr Adolesc Med. 2006 Jul;160(7):739-46 [16818840] Addiction. 2007 Feb;102(2):216-25 [17222275] J Stud Alcohol Drugs. 2007 Mar;68(2):256-65 [17286344] Drug Alcohol Depend. 2007 Jul 10;89(2-3):139-44 [17227698] Alcohol Clin Exp Res. 2007 Jun;31(6):928-38 [17403069] Drug Alcohol Depend. 2007 Nov 2;91(1):26-39 [17553635] Arch Pediatr Adolesc Med. 2007 Oct;161(10):959-66 [17909139] Drug Alcohol Depend. 2008 Jan 1;92(1-3):27-36 [17706375] Neuropsychologia. 2008 Jan 31;46(2):714-26 [17996909] Alcohol Clin Exp Res. 2008 Mar;32(3):373-4 [18302721] Alcohol Clin Exp Res. 2008 Mar;32(3):386-94 [18302722] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1530-0277.2008.00806.x ER - TY - JOUR T1 - The role of incretins in glucose homeostasis and diabetes treatment. AN - 69921890; 19074620 AB - Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within minutes after eating. One of their many physiological roles is to regulate the amount of insulin that is secreted after eating. In this manner, as well as others to be described in this review, their final common raison d'être is to aid in disposal of the products of digestion. There are two incretins, known as glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), that share many common actions in the pancreas but have distinct actions outside of the pancreas. Both incretins are rapidly deactivated by an enzyme called dipeptidyl peptidase 4 (DPP4). A lack of secretion of incretins or an increase in their clearance are not pathogenic factors in diabetes. However, in type 2 diabetes (T2DM), GIP no longer modulates glucose-dependent insulin secretion, even at supraphysiological (pharmacological) plasma levels, and therefore GIP incompetence is detrimental to beta-cell function, especially after eating. GLP-1, on the other hand, is still insulinotropic in T2DM, and this has led to the development of compounds that activate the GLP-1 receptor with a view to improving insulin secretion. Since 2005, two new classes of drugs based on incretin action have been approved for lowering blood glucose levels in T2DM: an incretin mimetic (exenatide, which is a potent long-acting agonist of the GLP-1 receptor) and an incretin enhancer (sitagliptin, which is a DPP4 inhibitor). Exenatide is injected subcutaneously twice daily and its use leads to lower blood glucose and higher insulin levels, especially in the fed state. There is glucose-dependency to its insulin secretory capacity, making it unlikely to cause low blood sugars (hypoglycemia). DPP4 inhibitors are orally active and they increase endogenous blood levels of active incretins, thus leading to prolonged incretin action. The elevated levels of GLP-1 are thought to be the mechanism underlying their blood glucose-lowering effects. JF - Pharmacological reviews AU - Kim, Wook AU - Egan, Josephine M AD - National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 470 EP - 512 VL - 60 IS - 4 KW - Hypoglycemic Agents KW - 0 KW - Incretins KW - Peptides KW - Pyrazines KW - Triazoles KW - Venoms KW - exenatide KW - 9P1872D4OL KW - Glucose KW - IY9XDZ35W2 KW - Sitagliptin Phosphate KW - TS63EW8X6F KW - Index Medicus KW - Hypoglycemic Agents -- therapeutic use KW - Animals KW - Venoms -- therapeutic use KW - Pyrazines -- therapeutic use KW - Humans KW - Triazoles -- therapeutic use KW - Peptides -- therapeutic use KW - Glucose -- metabolism KW - Incretins -- physiology KW - Homeostasis -- physiology KW - Diabetes Mellitus -- physiopathology KW - Diabetes Mellitus -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69921890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+reviews&rft.atitle=The+role+of+incretins+in+glucose+homeostasis+and+diabetes+treatment.&rft.au=Kim%2C+Wook%3BEgan%2C+Josephine+M&rft.aulast=Kim&rft.aufirst=Wook&rft.date=2008-12-01&rft.volume=60&rft.issue=4&rft.spage=470&rft.isbn=&rft.btitle=&rft.title=Pharmacological+reviews&rft.issn=1521-0081&rft_id=info:doi/10.1124%2Fpr.108.000604 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-12-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 2004 Aug;127(2):546-58 [15300587] Circulation. 2004 Aug 24;110(8):955-61 [15313949] Diabetes. 2004 Sep;53(9):2492-500 [15331566] Diabetes Care. 2004 Nov;27(11):2628-35 [15504997] Diabetes. 2004 Nov;53(11):2824-35 [15504962] J Clin Invest. 1967 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[10611300] Endocrinology. 2000 Feb;141(2):752-62 [10650957] Life Sci. 2000;66(2):91-103 [10666005] Endocrinology. 2000 Mar;141(3):1228-35 [10698200] Biochem Biophys Res Commun. 2000 Mar 16;269(2):331-5 [10708552] J Med Chem. 2000 May 4;43(9):1664-9 [10794683] Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1010-8 [10827002] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9 [10823914] Diabetes. 2000 May;49(5):741-8 [10905482] Diabetes. 2000 Jul;49(7):1156-64 [10909973] J Biol Chem. 2000 Sep 8;275(36):27989-99 [10869353] Biochem Pharmacol. 2002 Mar 1;63(5):993-6 [11911852] Diabetologia. 2002 Feb;45(2):195-202 [11935150] Exp Eye Res. 2002 Feb;74(2):231-6 [11950233] Bone. 2002 May;30(5):655-63 [11996901] Endocrinology. 2002 Jun;143(6):2303-13 [12021195] Endocrinology. 2002 Jun;143(6):2420-6 [12021207] J Endocrinol. 2002 Jun;173(3):465-73 [12065236] Nat Med. 2002 Jul;8(7):738-42 [12068290] J Clin Invest. 2002 Jul;110(1):43-52 [12093887] Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7 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Mar;145(3):1349-55 [14630721] Circulation. 2004 Mar 2;109(8):962-5 [14981009] Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E621-5 [14678954] J Endocrinol. 2004 Mar;180(3):389-98 [15012593] Nat Cell Biol. 2004 Mar;6(3):207-14 [15039777] Diabetes. 2004 May;53(5):1326-35 [15111503] Endocrinology. 2004 Jun;145(6):2687-95 [15001546] Diabetes Care. 2004 Jun;27(6):1335-42 [15161785] Diabetologia. 2004 May;47(5):806-15 [15095038] Diabetes Care. 2004 Jul;27(7):1692-8 [15220248] Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E199-206 [15271645] Bone. 2007 May;40(5):1352-60 [17321229] Int J Mol Med. 2007 Jun;19(6):961-6 [17487430] Gastroenterology. 2007 May;132(6):2131-57 [17498508] Diabetes. 2007 Jun;56(6):1551-8 [17360984] Diabetes. 2007 Jun;56(6):1671-9 [17369525] Diabetes Care. 2007 Jun;30(6):1487-93 [17353504] Diabetes Care. 2007 Jun;30(6):1608-10 [17372153] Eur J Clin Pharmacol. 2007 Jul;63(7):677-86 [17486328] Clin Pharmacokinet. 2007;46(7):577-88 [17596103] JAMA. 2007 Jul 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Endocrinology. 1985 Sep;117(3):817-23 [2862020] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/pr.108.000604 ER - TY - JOUR T1 - Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore. AN - 69916144; 19006141 AB - A search query consisting of two aromatic centers and two cationic centers was defined based on previously identified small molecule inhibitors of the botulinum neurotoxin serotype A light chain (BoNT/A LC) and used to mine the National Cancer Institute Open Repository. Ten small molecule hits were identified, and upon testing, three demonstrated inhibitory activity. Of these, one was structurally unique, possessing a rigid diazachrysene scaffold. The steric limitations of the diazachrysene imposed a separation between the overlaps of previously identified inhibitors, revealing an extended binding mode. As a result, the pharmacophore for BoNT/A LC inhibition has been modified to encompass three zones. To demonstrate the utility of this model, a novel three-zone inhibitor was mined and its activity was confirmed. JF - ChemMedChem AU - Hermone, Ann R AU - Burnett, James C AU - Nuss, Jonathan E AU - Tressler, Lyal E AU - Nguyen, Tam L AU - Solaja, Bogdan A AU - Vennerstrom, Jonathan L AU - Schmidt, James J AU - Wipf, Peter AU - Bavari, Sina AU - Gussio, Rick AD - Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc. National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1905 EP - 1912 VL - 3 IS - 12 KW - Chrysenes KW - 0 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Imaging, Three-Dimensional KW - Computer Simulation KW - Databases, Factual KW - Drug Design KW - Structure-Activity Relationship KW - Models, Molecular KW - Chrysenes -- pharmacology KW - Chrysenes -- chemistry KW - Botulinum Toxins, Type A -- antagonists & inhibitors KW - Botulinum Toxins, Type A -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69916144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ChemMedChem&rft.atitle=Three-dimensional+database+mining+identifies+a+unique+chemotype+that+unites+structurally+diverse+botulinum+neurotoxin+serotype+A+inhibitors+in+a+three-zone+pharmacophore.&rft.au=Hermone%2C+Ann+R%3BBurnett%2C+James+C%3BNuss%2C+Jonathan+E%3BTressler%2C+Lyal+E%3BNguyen%2C+Tam+L%3BSolaja%2C+Bogdan+A%3BVennerstrom%2C+Jonathan+L%3BSchmidt%2C+James+J%3BWipf%2C+Peter%3BBavari%2C+Sina%3BGussio%2C+Rick&rft.aulast=Hermone&rft.aufirst=Ann&rft.date=2008-12-01&rft.volume=3&rft.issue=12&rft.spage=1905&rft.isbn=&rft.btitle=&rft.title=ChemMedChem&rft.issn=1860-7187&rft_id=info:doi/10.1002%2Fcmdc.200800241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cmdc.200800241 ER - TY - JOUR T1 - Cognitive remediation in the treatment of stimulant abuse disorders: a research agenda. AN - 69901640; 19086769 AB - Treatment of substance abuse disorders is often characterized by high dropout rates. Patients who fail to complete a treatment course often are worse at follow-up than those patients who received the full treatment course. Cognitive deficits, including impulsivity, have been noted as a major determinant of treatment retention and successful outcomes. This review summarizes the recent literature on cognitive deficits in stimulant users and their remediation. Cognitive deficits can be remediated through computer-assisted cognitive rehabilitation in residential settings. A few studies have shown this can be transferred to the outpatient setting although much research remains to be done in this setting. Pharmacological remediation of cognitive deficits is a new target for medications development in the treatment of substance abuse disorders. Psychiatric disorders; for example, attention deficit hyperactivity disorder, are amenable to pharmacological remediation of cognitive deficits. Several cognitive deficits (set-shifting, attentional bias, reversal learning, impulsivity, and risky decision making) and their possible remediation with pharmacological agents are presented in the review. Recommendations for the research agenda include comments on testing hierarchies, clinical trial design issues, and types of pharmacological agents. (c) 2008 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Vocci, Frank J AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA. fvocci@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 484 EP - 497 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Central Nervous System Stimulants KW - 0 KW - Index Medicus KW - Impulsive Behavior -- complications KW - Humans KW - Patient Dropouts KW - Treatment Outcome KW - Impulsive Behavior -- therapy KW - Central Nervous System Stimulants -- adverse effects KW - Therapy, Computer-Assisted -- methods KW - Cognitive Therapy -- methods KW - Substance-Related Disorders -- physiopathology KW - Cognition Disorders -- therapy KW - Substance-Related Disorders -- rehabilitation KW - Cognition Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69901640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Cognitive+remediation+in+the+treatment+of+stimulant+abuse+disorders%3A+a+research+agenda.&rft.au=Vocci%2C+Frank+J&rft.aulast=Vocci&rft.aufirst=Frank&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014101 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1037/a0014101 ER - TY - JOUR T1 - Introduction to a symposium on recent advances in the development of medications for drug abuse treatment in honor of Jack H. Mendelson, M.D. AN - 69901562; 19086765 JF - Experimental and clinical psychopharmacology AU - Acri, Jane B AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA. jacri@nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 443 EP - 445 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Index Medicus KW - Mendelson KW - History, 21st Century KW - History, 20th Century KW - Humans KW - Clinical Trials as Topic KW - Male KW - Alcoholism -- rehabilitation KW - Alcoholism -- history KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69901562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Introduction+to+a+symposium+on+recent+advances+in+the+development+of+medications+for+drug+abuse+treatment+in+honor+of+Jack+H.+Mendelson%2C+M.D.&rft.au=Acri%2C+Jane+B&rft.aulast=Acri&rft.aufirst=Jane&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014102 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - People - Mendelson N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Mendelson DO - http://dx.doi.org/10.1037/a0014102 ER - TY - JOUR T1 - Dual dopamine/serotonin releasers: potential treatment agents for stimulant addiction. AN - 69897932; 19086767 AB - "Agonist therapy" for cocaine and methamphetamine addiction involves administration of stimulant-like medications (e.g., monoamine releasers) to reduce withdrawal symptoms and prevent relapse. A significant problem with this strategy is that many candidate medications possess abuse liability because of activation of mesolimbic dopamine (DA) neurons in the brain. One way to reduce DA-mediated abuse liability of candidate drugs is to add in serotonin (5-HT) releasing properties, since substantial evidence shows that 5-HT neurons provide an inhibitory influence over mesolimbic DA neurons. This article addresses several key issues related to the development of dual DA/5-HT releasers for the treatment of substance use disorders. First, the authors briefly summarize the evidence supporting a dual deficit in DA and 5-HT function during withdrawal from chronic cocaine or alcohol abuse. Second, the authors discuss data demonstrating that 5HT release can dampen DA-mediated stimulant effects, and the "antistimulant" role of 5-HT-sub(2C) receptors is considered. Next, the mechanisms underlying potential adverse effects of 5-HT releasers are described. Finally, the authors discuss recently published data with PAL-287, a novel nonamphetamine DA/5-HT releasing agent that suppresses cocaine self-administration but lacks positive reinforcing properties. It is concluded that DA/5-HT releasers could be useful therapeutic adjuncts for the treatment of cocaine and alcohol addictions, as well as for obesity, attention-deficit disorder, and depression. (c) 2008 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Rothman, Richard B AU - Blough, Bruce E AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, IRP/NIDA/NIH, Clinical Psychopharmacology Section, Suite 4500, Triad Building, 333 Cassell Drive, Baltimore, MD 21224, USA. rrothman@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 458 EP - 474 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Central Nervous System Stimulants KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Humans KW - Cocaine-Related Disorders -- drug therapy KW - Dopamine -- metabolism KW - Behavior, Addictive -- drug therapy KW - Serotonin -- metabolism KW - Substance-Related Disorders -- physiopathology KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance-Related Disorders -- drug therapy KW - Substance Withdrawal Syndrome -- drug therapy KW - Central Nervous System Stimulants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69897932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Dual+dopamine%2Fserotonin+releasers%3A+potential+treatment+agents+for+stimulant+addiction.&rft.au=Rothman%2C+Richard+B%3BBlough%2C+Bruce+E%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014103 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Heart Valve Dis. 2000 May;9(3):454-8 [10888105] Psychopharmacology 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[11071707] Chest. 2000 Nov;118(5):1496-7 [11083709] Neuroscience. 2007 Apr 25;146(1):286-97 [17367945] Neuroscience. 2007 Jun 8;146(4):1677-88 [17467185] Curr Opin Neurobiol. 2007 Jun;17(3):304-12 [17509873] Trends Pharmacol Sci. 2007 Jul;28(7):316-25 [17573127] Am J Cardiol. 2007 Nov 1;100(9):1442-5 [17950805] Neuropsychopharmacology. 2008 Jan;33(1):166-80 [17805308] J Pharmacol Exp Ther. 2008 Feb;324(2):791-7 [18032571] Am J Ther. 2010 Nov-Dec;17(6):596-603 [19352140] Br J Pharmacol. 1997 Dec;122(7):1455-63 [9421295] Pharmacol Biochem Behav. 1998 Mar;59(3):709-15 [9512076] Alcohol Clin Exp Res. 1998 Feb;22(1):3-9 [9514280] Am J Addict. 1998 Spring;7(2):142-55 [9598218] Ann N Y Acad Sci. 1998 May 30;844:59-74 [9668665] Synapse. 1998 Sep;30(1):107-11 [9704887] Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):87-96 [9716932] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1037/a0014103 ER - TY - JOUR T1 - Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs. AN - 69892991; 19075617 AB - Medicinal use of natural products such as extracts of plants has existed for many years in China and in other countries and they are now available worldwide. Citrus fruit juices are consumed on a daily basis around the world. Modern medicine provides well-tested compounds or drugs for most sicknesses. However, the simultaneous consumption of plant extracts, food supplements, and fruit juices with drugs can create metabolic aberrations in humans. Interactions between drugs used simultaneously are regulated by government agencies. Not regulated, but warned against in drug inserts are potential interactions between drugs and food and food-additives containing certain compounds with potential side effects. Summarized here are the results of investigations that point out possible interactions at the level of transporter molecules by drugs and compounds of natural origin. These transporter molecules play important roles in absorption in the intestines, at the blood brain barrier, in the liver, the kidney and in some other parts of the human body. Drugs and metabolites pass through these pumps and may compete with compounds from food supplements. The most studied natural compounds that are potential modulators of these transport molecules are flavonoids, found in fruit juices, vegetables, flowers and tea. Mycotoxins found in cereal grains are also shown to modulate transporter proteins. We detail here how such constituents of natural origin were shown to modulate three types of the major transporter molecules, P-glycoprotein (ABCB1), multidrug resistance proteins (ABCCs) and breast cancer resistance protein (ABCG2). Interference of these natural compounds with drugs at the transporter level is also discussed. JF - Current drug metabolism AU - Aszalos, Adorjan AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Room 2112, Bethesda, MD 20892, USA. aszalosa@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1010 EP - 1018 VL - 9 IS - 10 SN - 1389-2002, 1389-2002 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Multidrug Resistance-Associated Proteins KW - Neoplasm Proteins KW - P-Glycoprotein KW - multidrug resistance-associated protein 2 KW - 4AF605U6JN KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Multidrug Resistance-Associated Proteins -- physiology KW - P-Glycoprotein -- physiology KW - Neoplasm Proteins -- physiology KW - Humans KW - Citrus paradisi KW - ATP-Binding Cassette Transporters -- physiology KW - Food-Drug Interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69892991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+metabolism&rft.atitle=Role+of+ATP-binding+cassette+%28ABC%29+transporters+in+interactions+between+natural+products+and+drugs.&rft.au=Aszalos%2C+Adorjan&rft.aulast=Aszalos&rft.aufirst=Adorjan&rft.date=2008-12-01&rft.volume=9&rft.issue=10&rft.spage=1010&rft.isbn=&rft.btitle=&rft.title=Current+drug+metabolism&rft.issn=13892002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metal catalyzed oxidation of alpha-synuclein--a role for oligomerization in pathology? AN - 69891950; 19075587 AB - A number of studies have demonstrated a role for transition metals and oxidative stress in the etiology of Parkinson's disease (PD). Genetic and biochemical evidence also clearly links the protein alpha-synuclein (alphaSyn) to PD and a number of associated diseases. In these "synucleinopathies", alphaSyn is deposited, often in oligomerized forms, as cytoplasmic inclusions known as Lewy bodies and Lewy neurites. alphaSyn cross-linking/oligomerization can occur via a number of processes, most stimulated by metal catalyzed oxidation (MCO). In PD, the increased sensitivity of midbrain neurons expressing high levels of oxidizable catecholamines may provide one clue to account for degeneration of these neurons. In other regions of the nervous system that develop Lewy body pathology, the mode of alphaSyn oligomerization is less clear. Thus, the relationship between alphaSyn and MCO, either direct or indirect, represents a particular concern for possible treatment of these various diseases. JF - Current Alzheimer research AU - Cole, N B AD - Laboratory of Biochemistry, National Heart Lung and Blood Institute, 50 South Drive MSC 8012, Bethesda, Maryland 20892, USA. ncole@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 599 EP - 606 VL - 5 IS - 6 SN - 1567-2050, 1567-2050 KW - Metals KW - 0 KW - alpha-Synuclein KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Humans KW - Brain Chemistry -- drug effects KW - Lipid Peroxidation -- drug effects KW - Catalysis KW - Brain Chemistry -- physiology KW - alpha-Synuclein -- chemistry KW - Neurodegenerative Diseases -- metabolism KW - alpha-Synuclein -- toxicity KW - Neurodegenerative Diseases -- pathology KW - Metals -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69891950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=Metal+catalyzed+oxidation+of+alpha-synuclein--a+role+for+oligomerization+in+pathology%3F&rft.au=Cole%2C+N+B&rft.aulast=Cole&rft.aufirst=N&rft.date=2008-12-01&rft.volume=5&rft.issue=6&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=15672050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. AN - 69891348; 19075603 AB - Glucocerebrosidase (GC) catalyzes the hydrolysis of beta-glucocerebroside to glucose and ceramide in lysosomes. Mutations in the glucocerebrosidase gene (GBA) result in Gaucher disease, an autosomal recessive lysosomal storage disorder. Many of the mutations encountered in patients with Gaucher disease are missense alterations that may cause misfolding, decreased stability and/or mistrafficking of this lysosomal protein. Some inhibitors of GC have been shown to act as chemical chaperones, stabilizing the conformation of mutant proteins and thus restoring their function. High throughput screening (HTS) of small molecule libraries for such compounds with potential for chaperone therapy requires an accurate, reproducible and sensitive assay method. We have adapted and optimized two fluorogenic GC enzyme assays and miniaturized them into the 1536-well plate format for HTS. The two substrates, 4-methylumbelliferyl beta-D-glucopyranoside and resorufin beta-D-glucopyranoside, have K(m) values of 768 microM and 33 microM, respectively, and different emission spectra. Paired screening with the two assays helps to eliminate false inference of activity due to autofluorescence or fluorescence quenching by the screened compounds. Test screens with the LOPAC library indicated that both assays were robust for HTS, and gave comparable results for GC inhibitor activities. These two assays can be used to identify both GC activators and inhibitors with potential therapeutic value. JF - Combinatorial chemistry & high throughput screening AU - Urban, Daniel J AU - Zheng, Wei AU - Goker-Alpan, Ozlem AU - Jadhav, Ajit AU - Lamarca, Mary E AU - Inglese, James AU - Sidransky, Ellen AU - Austin, Christopher P AD - Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3708, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 817 EP - 824 VL - 11 IS - 10 SN - 1386-2073, 1386-2073 KW - Enzyme Inhibitors KW - 0 KW - Taurocholic Acid KW - 5E090O0G3Z KW - Glucosylceramidase KW - EC 3.2.1.45 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Spectrometry, Fluorescence KW - Kinetics KW - Hydrogen-Ion Concentration KW - Enzyme Inhibitors -- pharmacology KW - Miniaturization KW - Substrate Specificity KW - Inhibitory Concentration 50 KW - Glucosylceramidase -- analysis KW - Glucosylceramidase -- metabolism KW - Glucosylceramidase -- antagonists & inhibitors KW - Drug Evaluation, Preclinical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69891348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Combinatorial+chemistry+%26+high+throughput+screening&rft.atitle=Optimization+and+validation+of+two+miniaturized+glucocerebrosidase+enzyme+assays+for+high+throughput+screening.&rft.au=Urban%2C+Daniel+J%3BZheng%2C+Wei%3BGoker-Alpan%2C+Ozlem%3BJadhav%2C+Ajit%3BLamarca%2C+Mary+E%3BInglese%2C+James%3BSidransky%2C+Ellen%3BAustin%2C+Christopher+P&rft.aulast=Urban&rft.aufirst=Daniel&rft.date=2008-12-01&rft.volume=11&rft.issue=10&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=Combinatorial+chemistry+%26+high+throughput+screening&rft.issn=13862073&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-09 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15428-33 [12434014] Hum Mutat. 2008 May;29(5):567-83 [18338393] Mol Genet Metab. 2004 Sep-Oct;83(1-2):6-15 [15464415] Clin Chim Acta. 1975 May 1;60(3):391-6 [806404] Clin Chim Acta. 1976 Jul 15;70(2):247-57 [8226] Arch Biochem Biophys. 1976 Aug;175(2):569-82 [958319] Brain Res. 1977 Feb 18;122(2):325-35 [13910] Clin Chim Acta. 1978 Oct 16;89(2):293-9 [361294] Biochem J. 1980 Mar 1;185(3):583-91 [7387624] Clin Chem. 1982 Apr;28(4 Pt 1):569-77 [6804115] Anal Biochem. 1983 Apr 15;130(2):521-6 [6869839] Biochemistry. 1985 Jul 2;24(14):3530-9 [3929833] J Neurochem. 1990 Feb;54(2):699-702 [1967633] Cell Biochem Funct. 1993 Sep;11(3):167-77 [8403230] Agents Actions. 1993 Nov;40(3-4):186-90 [8023742] Biochim Biophys Acta. 1994 Jul 14;1213(2):176-82 [8025128] Anal Biochem. 1997 May 1;247(2):268-71 [9177687] Baillieres Clin Haematol. 1997 Dec;10(4):621-34 [9497855] Hepatology. 1998 Jul;28(1):156-63 [9657108] J Pathol. 1999 Aug;188(4):407-14 [10440752] J Biol Chem. 2005 Jun 24;280(25):23815-9 [15817452] Hum Mol Genet. 2005 Aug 15;14(16):2387-98 [16000318] Blood Cells Mol Dis. 2005 Sep-Oct;35(2):268-76 [16039881] J Biomol Screen. 2006 Feb;11(1):29-39 [16234337] Cell Mol Life Sci. 2006 May;63(10):1179-92 [16568247] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Nat Chem Biol. 2007 Feb;3(2):101-7 [17187079] Mol Genet Metab. 2007 Feb;90(2):122-5 [17084653] Expert Opin Pharmacother. 2007 Mar;8(4):427-35 [17309337] J Biomol Screen. 2007 Mar;12(2):203-10 [17208922] Nat Chem Biol. 2007 Aug;3(8):466-79 [17637779] Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7 [17670938] Trends Pharmacol Sci. 2003 Jul;24(7):355-60 [12871668] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical evaluation of paroxetine in post-traumatic stress disorder (PTSD): 52-week, non-comparative open-label study for clinical use experience. AN - 69876631; 19068000 AB - The present study was a 52-week, non-comparative, open-label study of flexible dose paroxetine (20-40 mg) in 52 Japanese post-traumatic stress disorder (PTSD) patients in order to obtain clinical experience regarding efficacy and safety in regular clinical practice. Efficacy was measured using the Clinician-Administered PTSD Scale One Week Symptom Status Version (CAPS-SX). The mean change from baseline in CAPS-SX total score was -19.1, -22.8 and -32.3 at weeks 4, 12 and 52, respectively, and that in the Clinical Global Impression (CGI) Severity of Illness score was -1.1 at week 12 and -1.7 at week 52. A total of 46.9% were CGI responders at week 12, while 67.3% were improved on the CGI at week 52. Of 52 subjects who entered into the drug treatment, 25 completed the study. Only one patient withdrew from the study due to lack of efficacy. In patients who were rated as 'moderately ill' or less at baseline, the proportion of CGI responders at end-point was higher at a dose of 20 mg/day than at higher doses, whereas in patients rated as 'markedly ill' or more, it was higher at 30 and 40 mg/day, suggesting that severely ill patients could benefit from higher doses. Paroxetine appeared generally tolerated in short- and long-term use, and the safety profile in this study was consistent with international trials and other Japanese populations (i.e. patients suffering from depression, panic disorder or obsessive-compulsive disorder). Although the study was not conducted in double-blind fashion, the current findings suggest that paroxetine may contribute to clinically meaningful improvement that is maintained during long-term use and is generally well tolerated. JF - Psychiatry and clinical neurosciences AU - Kim, Yoshiharu AU - Asukai, Nozomu AU - Konishi, Takako AU - Kato, Hiroshi AU - Hirotsune, Hideto AU - Maeda, Masaharu AU - Inoue, Hirotaka AU - Narita, Hiroyasu AU - Iwasaki, Masaru AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 646 EP - 652 VL - 62 IS - 6 KW - Serotonin Uptake Inhibitors KW - 0 KW - Paroxetine KW - 41VRH5220H KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Treatment Outcome KW - Cluster Analysis KW - Male KW - Female KW - Paroxetine -- administration & dosage KW - Serotonin Uptake Inhibitors -- administration & dosage KW - Stress Disorders, Post-Traumatic -- psychology KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Paroxetine -- therapeutic use KW - Paroxetine -- adverse effects KW - Stress Disorders, Post-Traumatic -- drug therapy KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69876631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+and+clinical+neurosciences&rft.atitle=Clinical+evaluation+of+paroxetine+in+post-traumatic+stress+disorder+%28PTSD%29%3A+52-week%2C+non-comparative+open-label+study+for+clinical+use+experience.&rft.au=Kim%2C+Yoshiharu%3BAsukai%2C+Nozomu%3BKonishi%2C+Takako%3BKato%2C+Hiroshi%3BHirotsune%2C+Hideto%3BMaeda%2C+Masaharu%3BInoue%2C+Hirotaka%3BNarita%2C+Hiroyasu%3BIwasaki%2C+Masaru&rft.aulast=Kim&rft.aufirst=Yoshiharu&rft.date=2008-12-01&rft.volume=62&rft.issue=6&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Psychiatry+and+clinical+neurosciences&rft.issn=1440-1819&rft_id=info:doi/10.1111%2Fj.1440-1819.2008.01862.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1819.2008.01862.x ER - TY - JOUR T1 - K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3'-azido-3'-deoxythymidine. AN - 69875691; 18800350 AB - A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program,2006]. The incidence of alveolar/bronchiolar adenomas and carcinomas in the 200 and 300 mg/kg groups was significantly higher (P = 0.027 and 0.007, respectively) in male offspring, but not in females (P = 0.338 and 0.315, respectively). The purpose of the present study was to evaluate K-ras mutation status in lung tumors from the female offspring in AZT exposed groups and to determine whether at the molecular level there were signature K-ras mutations in lung tumors that were different from spontaneous tumors. K-ras mutation was detected by cycle sequencing of polymerase chain reaction (PCR)-amplified DNA, isolated from formalin-fixed, paraffin-embedded lung tumors. K-ras mutations were detected in 17 of 28 (61%) lung tumors from the female offspring in AZT exposed groups. No K-ras mutations were detected in the 8 tumors examined from the female control group. The predominant mutations were Codon 12 G-->T transversions in the 50, 100, and 300 mg/kg groups, and Codon 12 G-->C transversions in the 200 and 300 mg/kg groups. K-ras Codon 12 G-->T transversions (TGT mutations) may be induced by oxidative DNA damage and 8-oxoguanine (8-oxoG), while K-ras Codon 12 G-->C transversions (CGT mutations) may be due to further oxidative lesions of guanine and 8-oxoG. JF - Environmental and molecular mutagenesis AU - Koujitani, Takatoshi AU - Ton, Tai-Vu T AU - Lahousse, Stephanie A AU - Hong, Hue-Hua L AU - Wakamatsu, Nobuko AU - Sills, Robert C AD - Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 720 EP - 726 VL - 49 IS - 9 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - Maternal Exposure -- adverse effects KW - Prenatal Exposure Delayed Effects -- etiology KW - Animals KW - Sex Factors KW - Mice KW - Male KW - Female KW - Prenatal Exposure Delayed Effects -- genetics KW - Pregnancy KW - Mutation -- drug effects KW - Lung Neoplasms -- etiology KW - Zidovudine -- toxicity KW - Genes, ras -- genetics KW - Lung Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69875691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=K-ras+cancer+gene+mutations+in+lung+tumors+from+female+Swiss+%28CD-1%29+mice+exposed+transplacentally+to+3%27-azido-3%27-deoxythymidine.&rft.au=Koujitani%2C+Takatoshi%3BTon%2C+Tai-Vu+T%3BLahousse%2C+Stephanie+A%3BHong%2C+Hue-Hua+L%3BWakamatsu%2C+Nobuko%3BSills%2C+Robert+C&rft.aulast=Koujitani&rft.aufirst=Takatoshi&rft.date=2008-12-01&rft.volume=49&rft.issue=9&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20420 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20420 ER - TY - JOUR T1 - Correlates of human papillomavirus viral load with infection site in asymptomatic men. AN - 69872936; 19064573 AB - Numerous studies have evaluated human papillomavirus (HPV) DNA load in women, especially HPV-16 viral load, and its role in cervical carcinogenicity. Few studies have examined HPV viral load in men, none among asymptomatic men. The aim of the current study is to quantify HPV-16 viral load in male anogenital specimens and to explore its correlates with anatomic sites. Two-hundred and ninety-four specimens from 42 men who tested positive for HPV-16 at one or more anatomic sites were evaluated. HPV DNA was detected with PGMY 09/11 primer and genotyped with reverse line blot assay followed by HPV-16 viral quantification using type-specific real-time PCR assay (TaqMan). The quantitative PCR assay showed a higher sensitivity in HPV-16 viral DNA detection compared with the reverse line blot assay. Viral load varied significantly by anatomic site (P = 0.019). Penile shaft specimens had significantly higher viral load than any other anatomic site evaluated except for the anal canal. HPV-16 viral load was positively correlated between proximal anatomic sites: perianal and anal canal (P = 0.003), perianal and scrotum (P = 0.011), scrotum and glans/corona (P = 0.045), and scrotum and penile shaft (P = 0.037). In conclusion, the penile shaft seemed to be the preferred site for HPV-16 viral replication. Viral load correlation between proximal sites suggested a possible autoinoculation in male HPV transmission. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Flores, Roberto AU - Lu, Beibei AU - Beibei, Lu AU - Nielson, Carrie AU - Abrahamsen, Martha AU - Wolf, Kyle AU - Lee, Ji-Hyun AU - Harris, Robin B AU - Giuliano, Anna R AD - Cancer Prevention Fellowship Program, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS Suite T-41, Bethesda, MD 20892-7105, USA. rflores@jhsph.edu Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3573 EP - 3576 VL - 17 IS - 12 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Virus Replication KW - Viral Load KW - Sensitivity and Specificity KW - Genotype KW - Cross-Sectional Studies KW - Penis -- virology KW - Humans KW - Adult KW - Reverse Transcriptase Polymerase Chain Reaction KW - Statistics, Nonparametric KW - Male KW - Human papillomavirus 16 -- isolation & purification KW - Papillomavirus Infections -- virology KW - Human papillomavirus 16 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69872936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Correlates+of+human+papillomavirus+viral+load+with+infection+site+in+asymptomatic+men.&rft.au=Flores%2C+Roberto%3BLu%2C+Beibei%3BBeibei%2C+Lu%3BNielson%2C+Carrie%3BAbrahamsen%2C+Martha%3BWolf%2C+Kyle%3BLee%2C+Ji-Hyun%3BHarris%2C+Robin+B%3BGiuliano%2C+Anna+R&rft.aulast=Flores&rft.aufirst=Roberto&rft.date=2008-12-01&rft.volume=17&rft.issue=12&rft.spage=3573&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0467 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):216 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0467 ER - TY - JOUR T1 - High incidence of oral dysesthesias on a trial of gefitinib, Paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers. AN - 69871530; 19060587 AB - To report a high incidence of oral mucosal dysesthesia occurring in patients on a pilot study of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa) in combination with paclitaxel (Taxol) and external beam radiation therapy for the treatment of locally advanced squamous cell carcinoma of the head and neck. Nine patients were enrolled on a pilot phase I trial of oral gefitinib 250 mg/d with 6 weekly doses of paclitaxel (36 or 45 mg/m) and concurrent radiation therapy [66-76 Gray (Gy)]. All had stage III/IVA-B squamous cell carcinoma of the head and neck. Patients were evaluated twice weekly by physicians and daily by nursing for adverse events. Six of 9 patients (67%) developed a grade 3 "burning" quality oral dysesthesia. These patients received at least 50 Gy (range 50-70 Gy) to the oral tongue. The patients without grade 3 oral dysesthesia received less than 50 Gy radiation to the oral tongue. The oral dysesthesia was exacerbated by the ingestion of neutral pH liquids such as water. Of the 6 patients, all eventually developed common toxicity criteria grade 3/4 mucositis; however, symptoms continued after resolution of the mucositis. Gabapentin (Neurontin) was administered to 2 patients as a treatment for painful mucosal neuropathy. Both patients had near resolution of symptoms despite the evolution of oral mucositis. Development of "burning"-type oral dysesthesia occurred in patients treated with the combination of gefitinib, paclitaxel, and external beam radiation of the oral tongue. This dysesthesia was improved by the use of gabapentin. JF - American journal of clinical oncology AU - Sharp, Hadley AU - Morris, John C AU - Van Waes, Carter AU - Gius, David AU - Cooley-Zgela, Theresa AU - Singh, Anurag K AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 557 EP - 560 VL - 31 IS - 6 KW - Amines KW - 0 KW - Anticonvulsants KW - Cyclohexanecarboxylic Acids KW - Quinazolines KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - gabapentin KW - 6CW7F3G59X KW - Paclitaxel KW - P88XT4IS4D KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Prognosis KW - Aged KW - Amines -- therapeutic use KW - Cyclohexanecarboxylic Acids -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Quinazolines -- administration & dosage KW - gamma-Aminobutyric Acid -- therapeutic use KW - Adult KW - Incidence KW - Middle Aged KW - Female KW - Male KW - Radiation Injuries -- drug therapy KW - Paresthesia -- chemically induced KW - Head and Neck Neoplasms -- pathology KW - Paresthesia -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Stomatitis -- drug therapy KW - Head and Neck Neoplasms -- drug therapy KW - Radiotherapy -- adverse effects KW - Stomatitis -- chemically induced KW - Head and Neck Neoplasms -- therapy KW - Carcinoma, Squamous Cell -- pathology KW - Head and Neck Neoplasms -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy KW - Radiation Injuries -- etiology KW - Carcinoma, Squamous Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69871530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=High+incidence+of+oral+dysesthesias+on+a+trial+of+gefitinib%2C+Paclitaxel%2C+and+concurrent+external+beam+radiation+for+locally+advanced+head+and+neck+cancers.&rft.au=Sharp%2C+Hadley%3BMorris%2C+John+C%3BVan+Waes%2C+Carter%3BGius%2C+David%3BCooley-Zgela%2C+Theresa%3BSingh%2C+Anurag+K&rft.aulast=Sharp&rft.aufirst=Hadley&rft.date=2008-12-01&rft.volume=31&rft.issue=6&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=1537-453X&rft_id=info:doi/10.1097%2FCOC.0b013e318172d5de LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-13 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/COC.0b013e318172d5de ER - TY - JOUR T1 - Small toxic proteins and the antisense RNAs that repress them. AN - 69866027; 19052321 AB - There has been a great expansion in the number of small regulatory RNAs identified in bacteria. Some of these small RNAs repress the synthesis of potentially toxic proteins. Generally the toxin proteins are hydrophobic and less than 60 amino acids in length, and the corresponding antitoxin small RNA genes are antisense to the toxin genes or share long stretches of complementarity with the target mRNAs. Given their short length, only a limited number of these type I toxin-antitoxin loci have been identified, but it is predicted that many remain to be found. Already their characterization has given insights into regulation by small RNAs, has suggested functions for the small toxic proteins at the cell membrane, and has led to practical applications for some of the type I toxin-antitoxin loci. JF - Microbiology and molecular biology reviews : MMBR AU - Fozo, Elizabeth M AU - Hemm, Matthew R AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 18 Library Drive, Bethesda, MD 20892-5430, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 579 EP - 89, Table of Contents VL - 72 IS - 4 KW - Antitoxins KW - 0 KW - Bacterial Toxins KW - RNA, Antisense KW - RNA, Bacterial KW - Index Medicus KW - Antitoxins -- genetics KW - Enterobacteriaceae -- genetics KW - Chromosomes, Bacterial -- genetics KW - Enterobacteriaceae -- metabolism KW - Gene Expression Regulation, Bacterial KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- antagonists & inhibitors KW - Bacterial Toxins -- metabolism KW - RNA, Bacterial -- metabolism KW - RNA, Antisense -- metabolism KW - RNA, Bacterial -- genetics KW - RNA, Antisense -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69866027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+and+molecular+biology+reviews+%3A+MMBR&rft.atitle=Small+toxic+proteins+and+the+antisense+RNAs+that+repress+them.&rft.au=Fozo%2C+Elizabeth+M%3BHemm%2C+Matthew+R%3BStorz%2C+Gisela&rft.aulast=Fozo&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=72&rft.issue=4&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Microbiology+and+molecular+biology+reviews+%3A+MMBR&rft.issn=1098-5557&rft_id=info:doi/10.1128%2FMMBR.00025-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2008-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1999 Dec 17;294(5):1115-25 [10600370] Mol Microbiol. 2008 Dec;70(5):1076-93 [18710431] Mol Microbiol. 2000 Aug;37(3):652-60 [10931358] Mol Microbiol. 2000 Aug;37(3):661-70 [10931359] Curr Biol. 2001 Jun 26;11(12):941-50 [11448770] J Biol Chem. 2001 Sep 21;276(38):35707-13 [11461923] Mol Microbiol. 2001 Oct;42(2):527-37 [11703673] Mol Microbiol. 2002 Jul;45(2):333-49 [12123448] J Biotechnol. 2003 Jan 9;100(1):1-12 [12413781] Res Microbiol. 2002 Oct;153(8):493-501 [12437210] J Bacteriol. 2003 Apr;185(7):2169-77 [12644486] Br J Cancer. 2003 Jul 7;89(1):192-8 [12838323] Science. 2003 Sep 12;301(5639):1496-9 [12970556] Science. 1975 Jan 24;187(4173):257-8 [1089310] J Bacteriol. 1977 Dec;132(3):784-9 [336605] J Bacteriol. 1980 Nov;144(2):833-5 [6159347] Microbiol Immunol. 1982;26(9):779-93 [6185827] Biochim Biophys Acta. 1983 Jan 20;739(1):27-34 [6187365] J Bacteriol. 1985 Jan;161(1):292-8 [2981804] Proc Natl Acad Sci U S A. 1986 May;83(10):3116-20 [3517851] Biochim Biophys Acta. 1986 Jun 20;867(3):81-8 [2424508] EMBO J. 1986 Aug;5(8):2023-9 [3019679] Gene. 1988 Jun 30;66(2):259-68 [3049248] Mol Microbiol. 1990 Nov;4(11):1807-18 [1707122] New Biol. 1990 Nov;2(11):946-56 [2101633] Mol Microbiol. 1991 Jul;5(7):1627-37 [1943700] J Mol Biol. 1992 Jan 5;223(1):41-54 [1370544] Mol Microbiol. 1991 Aug;5(8):1961-73 [1722558] Mol Microbiol. 1992 Apr;6(7):895-905 [1602968] J Mol Biol. 1992 Aug 5;226(3):637-49 [1380562] Biotechnol Prog. 1994 Nov-Dec;10(6):621-9 [7765697] Plasmid. 1994 Sep;32(2):168-81 [7531349] J Bacteriol. 1996 Apr;178(7):2044-50 [8606182] Mol Microbiol. 1996 Apr;20(1):53-63 [8861204] Mol Microbiol. 1996 Sep;21(5):1049-60 [8885274] Appl Environ Microbiol. 1997 May;63(5):1917-24 [9143123] J Mol Biol. 1997 Oct 17;273(1):38-51 [9367744] Mol Microbiol. 1999 Jun;32(5):1090-102 [10361310] Curr Biol. 2004 Dec 29;14(24):2271-6 [15620655] Nucleic Acids Res. 2005;33(3):1040-50 [15718303] Nat Rev Microbiol. 2005 May;3(5):371-82 [15864262] J Bacteriol. 2005 Oct;187(19):6641-50 [16166525] Trends Biochem Sci. 2005 Dec;30(12):672-9 [16257530] J Bacteriol. 2006 Aug;188(15):5374-84 [16855226] Biochem J. 2006 Oct 1;399(1):1-7 [16956326] Nucleic Acids Res. 2006;34(20):5915-22 [17065468] Curr Opin Microbiol. 2007 Apr;10(2):117-24 [17376733] Curr Opin Microbiol. 2007 Apr;10(2):96-101 [17383222] Curr Opin Microbiol. 2007 Apr;10(2):134-9 [17383928] Curr Opin Microbiol. 2007 Apr;10(2):125-33 [17395525] Mol Microbiol. 2007 May;64(3):738-54 [17462020] Mol Cell. 2007 May 11;26(3):381-92 [17499044] Curr Opin Microbiol. 2007 Jun;10(3):257-61 [17553733] J Mol Microbiol Biotechnol. 2007;13(4):200-9 [17827970] Mol Microbiol. 2008 Oct;70(1):258-70 [18761622] Res Microbiol. 1999 Nov-Dec;150(9-10):653-64 [10673004] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MMBR.00025-08 ER - TY - JOUR T1 - Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation. AN - 69863815; 18701433 AB - Squamous cell carcinoma accounts for 20% of all human lung cancers and is strongly linked to cigarette smoking. It develops through premalignant changes that are characterized by high levels of keratin 14 (K14) expression in the airway epithelium and evolve through basal cell hyperplasia, squamous metaplasia and dysplasia to carcinoma in situ and invasive carcinoma. In order to explore the impact of K14 in the pulmonary epithelium that normally lacks both squamous differentiation and K14 expression, human keratin 14 gene hK14 was constitutively expressed in mouse airway progenitor cells using a mouse Clara cell specific 10 kDa protein (CC10) promoter. While the lungs of CC10-hK14 transgenic mice developed normally, we detected increased expression of K14 and the molecular markers of squamous differentiation program such as involucrin, loricrin, small proline-rich protein 1A, transglutaminase 1 and cholesterol sulfotransferase 2B1. In contrast, wild-type lungs were negative. Aging CC10-hK14 mice revealed multifocal airway cell hyperplasia, occasional squamous metaplasia and their lung tumors displayed evidence for multidirectional differentiation. We conclude that constitutive expression of hK14 initiates squamous differentiation program in the mouse lung, but fails to promote squamous maturation. Our study provides a novel model for assessing the mechanisms of premalignant lesions in vivo by modifying differentiation and proliferation of airway progenitor cells. JF - Carcinogenesis AU - Dakir, E L Habib AU - Feigenbaum, Lionel AU - Linnoila, R Ilona AD - Experimental Pathology Section, Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2377 EP - 2384 VL - 29 IS - 12 KW - KRT14 protein, human KW - 0 KW - Keratin-14 KW - Index Medicus KW - Animals KW - Blotting, Western KW - Transfection KW - Humans KW - Immunoprecipitation KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Transgenic KW - Immunohistochemistry KW - Keratin-14 -- genetics KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinoma, Squamous Cell -- metabolism KW - Precancerous Conditions -- metabolism KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- genetics KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- genetics KW - Lung Neoplasms -- genetics KW - Cell Transformation, Neoplastic -- genetics KW - Keratin-14 -- metabolism KW - Lung Neoplasms -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69863815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Constitutive+expression+of+human+keratin+14+gene+in+mouse+lung+induces+premalignant+lesions+and+squamous+differentiation.&rft.au=Dakir%2C+E+L+Habib%3BFeigenbaum%2C+Lionel%3BLinnoila%2C+R+Ilona&rft.aulast=Dakir&rft.aufirst=E+L&rft.date=2008-12-01&rft.volume=29&rft.issue=12&rft.spage=2377&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn190 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-28 N1 - Date created - 2008-12-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Cell Biol. 1990 Dec;2(6):1028-35 [1712211] Cancer Res. 1990 Jan 1;50(1):120-8 [1967140] Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;61(6):375-87 [1349777] J Natl Cancer Inst Monogr. 1992;(13):93-100 [1327037] Biochem Biophys Res Commun. 1993 Nov 30;197(1):163-71 [7916613] J Biol Chem. 1995 Feb 10;270(6):2689-94 [7852338] Cell Growth Differ. 1997 Feb;8(2):145-55 [9040936] J Cell Biol. 1998 Oct 19;143(2):487-99 [9786957] Gene. 1998 Dec 11;224(1-2):59-66 [9931436] Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L625-32 [15579627] Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40 [15803139] Am J Respir Cell Mol Biol. 2005 Nov;33(5):455-62 [16055670] Curr Mol Med. 2007 Feb;7(1):3-14 [17311529] J Pharmacol Exp Ther. 2007 Aug;322(2):529-40 [17496163] Nature. 2007 Aug 16;448(7155):807-10 [17676035] Annu Rev Pathol. 2006;1:331-48 [18039118] J Invest Dermatol. 2008 Jun;128(6):1517-24 [18049449] J Cell Biol. 2000 Apr 3;149(1):17-22 [10747083] Cancer Res. 2000 Aug 1;60(15):4005-9 [10945598] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13031-6 [11698679] Methods. 2001 Dec;25(4):402-8 [11846609] Transgenic Res. 2002 Feb;11(1):21-9 [11874100] Respir Res. 2002;3:20 [11980589] Histopathology. 2002 May;40(5):403-39 [12010363] Pathol Int. 2002 Apr;52(4):286-93 [12031084] Bioessays. 2002 Sep;24(9):789-800 [12210515] Am J Pathol. 2004 Feb;164(2):577-88 [14742263] Cancer Res. 2004 Mar 1;64(5):1647-54 [14996723] J Invest Dermatol. 2004 May;122(5):1207-13 [15140224] J Mol Biol. 1975 Nov 5;98(3):503-17 [1195397] Lab Invest. 1978 Jun;38(6):648-53 [661220] J Anat. 1981 Jan;132(Pt 1):71-84 [7275793] Cell. 1982 Nov;31(1):11-24 [6186379] Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(2):221-40 [6143448] Proc Natl Acad Sci U S A. 1984 Apr;81(7):1991-5 [6326095] Anal Biochem. 1984 Feb;137(1):266-7 [6329026] J Immunol. 1985 Oct;135(4):2589-92 [4031496] EMBO J. 1986 Jul;5(7):1567-75 [3017704] Cell. 1987 Feb 13;48(3):453-63 [2433047] Lab Invest. 1987 Aug;57(2):219-29 [3613528] J Invest Dermatol. 1989 Feb;92(2):203-9 [2465352] Mol Cell Biol. 1989 Sep;9(9):3685-97 [2476664] Am J Clin Pathol. 1992 Feb;97(2):233-43 [1372146] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn190 ER - TY - JOUR T1 - Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. AN - 69852194; 19047179 AB - Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here, we describe the involvement of BRCA2 in O6-alkylguanine DNA alkyltransferase (AGT)-mediated repair of O6-methylguanine adducts. We show that BRCA2 physically associates and undergoes repair-mediated degradation with AGT. In contrast, BRCA2 with a 29-amino-acid deletion in an evolutionarily conserved domain does not bind to alkylated AGT; the two proteins are not degraded; and mouse embryonic fibroblasts are specifically sensitive to alkylating agents that result in O6-methylguanine adducts. We show that O6-benzylguanine (O6BG), a nontoxic inhibitor of AGT, can also induce BRCA2 degradation. BRCA2 is a viable target for cancer therapy because BRCA2-deficient cells are hypersensitive to chemotherapeutic DNA-damaging agents. We show a marked effect of O6BG pretreatment on cell sensitivity to cisplatin. We also show the efficacy of this approach on a wide range of human tumor cell lines, which suggests that chemosensitization of tumors by targeted degradation of BRCA2 may be an important consideration when devising cancer therapeutics. JF - Cancer research AU - Philip, Subha AU - Swaminathan, Srividya AU - Kuznetsov, Sergey G AU - Kanugula, Sreenivas AU - Biswas, Kajal AU - Chang, Suhwan AU - Loktionova, Natalia A AU - Haines, Diana C AU - Kaldis, Philipp AU - Pegg, Anthony E AU - Sharan, Shyam K AD - Mouse Cancer Genetics Program, Center for Cancer Research, and Pathology Histotechnology Laboratory, Science Applications International Corporation-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 9973 EP - 9981 VL - 68 IS - 23 KW - Alkylating Agents KW - 0 KW - BRCA2 Protein KW - BRCA2 protein, mouse KW - O(6)-benzylguanine KW - 01KC87F8FE KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - Guanine KW - 5Z93L87A1R KW - O-(6)-methylguanine KW - 9B710FV2AE KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Index Medicus KW - Animals KW - Humans KW - Molecular Sequence Data KW - Mice KW - Guanine -- analogs & derivatives KW - Amino Acid Sequence KW - Mice, Transgenic KW - Guanine -- pharmacology KW - Guanine -- metabolism KW - Mice, Knockout KW - Gene Deletion KW - DNA Repair -- physiology KW - O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors KW - O(6)-Methylguanine-DNA Methyltransferase -- metabolism KW - BRCA2 Protein -- metabolism KW - BRCA2 Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69852194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Degradation+of+BRCA2+in+alkyltransferase-mediated+DNA+repair+and+its+clinical+implications.&rft.au=Philip%2C+Subha%3BSwaminathan%2C+Srividya%3BKuznetsov%2C+Sergey+G%3BKanugula%2C+Sreenivas%3BBiswas%2C+Kajal%3BChang%2C+Suhwan%3BLoktionova%2C+Natalia+A%3BHaines%2C+Diana+C%3BKaldis%2C+Philipp%3BPegg%2C+Anthony+E%3BSharan%2C+Shyam+K&rft.aulast=Philip&rft.aufirst=Subha&rft.date=2008-12-01&rft.volume=68&rft.issue=23&rft.spage=9973&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1179 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Mol Mutagen. 2001;38(2-3):235-43 [11746760] Clin Cancer Res. 2007 May 1;13(9):2728-37 [17473206] Cancer Res. 2002 Feb 15;62(4):990-4 [11861370] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13920-5 [10570174] Mutat Res. 2000 Apr;462(2-3):83-100 [10767620] Genesis. 2001 Jan;29(1):14-21 [11135458] Oncogene. 2001 Jul 5;20(30):3937-48 [11494122] Bioessays. 2002 Mar;24(3):255-66 [11891762] J Clin Oncol. 2002 May 1;20(9):2388-99 [11981013] Science. 2002 Jul 26;297(5581):606-9 [12065746] Genes Chromosomes Cancer. 2003 Apr;36(4):317-31 [12619154] Mol Cancer Ther. 2003 Jul;2(7):633-40 [12883036] Nat Rev Cancer. 2004 Apr;4(4):296-307 [15057289] J Biol Chem. 1982 Nov 25;257(22):13776-80 [6754717] Proc Natl Acad Sci U S A. 1990 Jul;87(14):5368-72 [2164681] Carcinogenesis. 1991 Sep;12(9):1679-83 [1893528] J Med Chem. 1992 Nov 13;35(23):4486-91 [1447749] Prog Nucleic Acid Res Mol Biol. 1995;51:167-223 [7659775] Biochemistry. 1996 Jan 30;35(4):1328-34 [8573590] Carcinogenesis. 1996 Jun;17(6):1215-20 [8681434] Nature. 1997 Apr 24;386(6627):804-10 [9126738] Genes Dev. 1997 May 15;11(10):1226-41 [9171368] Genes Dev. 1997 May 15;11(10):1242-52 [9171369] Cancer Res. 1997 Jun 15;57(12):2415-8 [9192819] Nat Genet. 1997 Dec;17(4):423-30 [9398843] J Biol Chem. 1997 Dec 19;272(51):31941-4 [9405383] Cancer Res. 1998 Apr 1;58(7):1338-43 [9537225] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5287-92 [9560268] Mol Cell. 1998 Feb;1(3):347-57 [9660919] J Natl Cancer Inst. 1998 Jul 1;90(13):978-85 [9665145] Hum Genet. 1998 Aug;103(2):154-61 [9760198] Annu Rev Genet. 1998;32:95-121 [9928476] Mutagenesis. 1999 May;14(3):339-47 [10375003] J Pharmacol Exp Ther. 2005 Jan;312(1):206-13 [15304523] Clin Exp Metastasis. 2004;21(6):543-52 [15679052] Cancer Chemother Pharmacol. 2005 Apr;55(4):333-42 [15723259] Nature. 2005 Apr 14;434(7035):913-7 [15829966] Nature. 2005 Apr 14;434(7035):917-21 [15829967] Genes Chromosomes Cancer. 2005 Dec;44(4):429-37 [16127665] Cancer Res. 2005 Nov 15;65(22):10145-8 [16287996] Cancer Treat Rev. 2006 Jun;32(4):261-76 [16698182] Int J Biol Sci. 2006;2(4):179-85 [16810332] Curr Opin Pharmacol. 2006 Aug;6(4):355-63 [16777483] Oncogene. 2006 Sep 25;25(43):5885-97 [16998503] Cancer Treat Rev. 2007 Feb;33(1):9-23 [17084534] Cell. 2002 Jan 25;108(2):171-82 [11832208] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1179 ER - TY - JOUR T1 - Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. AN - 69848358; 18773491 AB - Nodal signaling is a critical regulator of multiple aspects of early vertebrate development including asymmetry along the left/right (LR) axis. To study Nodal function occurring specifically in the postgastrulation embryo, we have used Cre/loxP based conditional mutagenesis. A floxed allele of Nodal was generated and shown to have wild-type function. This allele was then used in conjunction with the T-Cre line, which expresses Cre recombinase broadly in the mesodermal and definitive endodermal lineages posterior to the cranial region. T-Cre activity leads to complete deletion of Nodal before its normal transient expression in the early somite stage lateral plate mesoderm, thereby causing severe LR developmental defects. No other abnormalities were found, suggesting that Nodal signaling has no additional essential functions in developmental patterning within the extensive mesodermal and endodermal domains marked by T-Cre activity. JF - Developmental dynamics : an official publication of the American Association of Anatomists AU - Kumar, Amit AU - Lualdi, Margaret AU - Lewandoski, Mark AU - Kuehn, Michael R AD - Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3591 EP - 3601 VL - 237 IS - 12 SN - 1058-8388, 1058-8388 KW - Nodal Protein KW - 0 KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Index Medicus KW - Body Patterning KW - Animals KW - Integrases -- genetics KW - Mice KW - Mice, Transgenic KW - Embryo, Mammalian -- metabolism KW - Gene Deletion KW - Phenotype KW - Alleles KW - Base Sequence KW - Genes, Reporter -- genetics KW - Integrases -- metabolism KW - Embryo, Mammalian -- embryology KW - Mutation -- genetics KW - Gene Expression Regulation, Developmental KW - Mesoderm -- embryology KW - Nodal Protein -- genetics KW - Endoderm -- embryology KW - Gastrointestinal Tract -- metabolism KW - Gastrointestinal Tract -- embryology KW - Endoderm -- metabolism KW - Mesoderm -- metabolism KW - Nodal Protein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69848358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+dynamics+%3A+an+official+publication+of+the+American+Association+of+Anatomists&rft.atitle=Broad+mesodermal+and+endodermal+deletion+of+Nodal+at+postgastrulation+stages+results+solely+in+left%2Fright+axial+defects.&rft.au=Kumar%2C+Amit%3BLualdi%2C+Margaret%3BLewandoski%2C+Mark%3BKuehn%2C+Michael+R&rft.aulast=Kumar&rft.aufirst=Amit&rft.date=2008-12-01&rft.volume=237&rft.issue=12&rft.spage=3591&rft.isbn=&rft.btitle=&rft.title=Developmental+dynamics+%3A+an+official+publication+of+the+American+Association+of+Anatomists&rft.issn=10588388&rft_id=info:doi/10.1002%2Fdvdy.21665 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genesis. 2000 Feb;26(2):118-20 [10686603] Genesis. 2007 Dec;45(12):729-36 [18064671] Development. 2001 May;128(10):1831-43 [11311163] Nat Rev Genet. 2001 Oct;2(10):743-55 [11584291] Genes Dev. 2002 Sep 15;16(18):2339-44 [12231623] Dev Biol. 2003 Apr 1;256(1):160-72 [12654299] BMC Dev Biol. 2001;1:4 [11299042] Dev Cell. 2004 Jan;6(1):7-28 [14723844] Semin Cell Dev Biol. 2004 Oct;15(5):543-54 [15271300] Semin Cell Dev Biol. 2004 Oct;15(5):555-61 [15271301] Dev Biol. 2004 Sep 1;273(1):149-59 [15302604] Mol Cell Biol. 2004 Nov;24(21):9383-9 [15485907] Dev Dyn. 1992 Jul;194(3):198-208 [1467556] Nature. 1993 Feb 11;361(6412):543-7 [8429908] Development. 1994 Jul;120(7):1919-28 [7924997] Nature. 1996 May 9;381(6578):158-61 [8610013] Genes Dev. 1997 Jul 15;11(14):1812-26 [9242489] Nat Genet. 1998 Feb;18(2):136-41 [9462741] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3667-72 [9520423] Nat Genet. 1999 Jan;21(1):70-1 [9916792] Mech Dev. 2005 Jan;122(1):3-25 [15582774] Development. 2005 Sep;132(17):3859-71 [16049111] Cell. 2006 Apr 7;125(1):33-45 [16615888] Dev Biol. 2006 May 15;293(2):370-81 [16564040] Cell. 2006 Oct 6;127(1):27-32 [17018270] Differentiation. 2007 Feb;75(2):133-46 [17316383] Development. 2007 Mar;134(6):1023-34 [17287255] Methods Mol Biol. 2000;137:125-37 [10948531] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/dvdy.21665 ER - TY - JOUR T1 - Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. AN - 69847827; 19047460 AB - Cellular responses to both physiological and pathological DNA double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (ATM) kinase. Upon DNA damage, an activation mechanism involving autophosphorylation has been reported to allow ATM to phosphorylate downstream targets important for cell cycle checkpoints and DNA repair. In humans, serine residues 367, 1893, and 1981 have been shown to be autophosphorylation sites that are individually required for ATM activation. To test the physiological importance of these sites, we generated a transgenic mouse model in which all three conserved ATM serine autophosphorylation sites (S367/1899/1987) have been replaced with alanine. In this study, we show that ATM-dependent responses at both cellular and organismal levels are functional in mice that express a triple serine mutant form of ATM as their sole ATM species. These results lend further support to the notion that ATM autophosphorylation correlates with the DNA damage-induced activation of the kinase but is not required for ATM function in vivo. JF - The Journal of cell biology AU - Daniel, Jeremy A AU - Pellegrini, Manuela AU - Lee, Ji-Hoon AU - Paull, Tanya T AU - Feigenbaum, Lionel AU - Nussenzweig, André AD - Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 777 EP - 783 VL - 183 IS - 5 KW - Cell Cycle Proteins KW - 0 KW - DNA-Binding Proteins KW - Tumor Suppressor Proteins KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Atm protein, mouse KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Animals KW - Enzyme Activation KW - Genes, cdc KW - Mice KW - Amino Acid Sequence KW - Dose-Response Relationship, Radiation KW - Mice, Transgenic KW - Intestine, Small -- radiation effects KW - Phosphorylation KW - Genomic Instability KW - Cells, Cultured KW - Recombination, Genetic KW - Molecular Sequence Data KW - Lymphocytes -- enzymology KW - Testis -- enzymology KW - Mutation KW - Male KW - Intestine, Small -- enzymology KW - Cell Nucleus -- enzymology KW - Protein-Serine-Threonine Kinases -- metabolism KW - Cell Cycle Proteins -- genetics KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - DNA-Binding Proteins -- genetics KW - Protein-Serine-Threonine Kinases -- genetics KW - DNA Breaks, Double-Stranded KW - Cell Nucleus -- radiation effects KW - DNA-Binding Proteins -- metabolism KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69847827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Multiple+autophosphorylation+sites+are+dispensable+for+murine+ATM+activation+in+vivo.&rft.au=Daniel%2C+Jeremy+A%3BPellegrini%2C+Manuela%3BLee%2C+Ji-Hoon%3BPaull%2C+Tanya+T%3BFeigenbaum%2C+Lionel%3BNussenzweig%2C+Andr%C3%A9&rft.aulast=Daniel&rft.aufirst=Jeremy&rft.date=2008-12-01&rft.volume=183&rft.issue=5&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=1540-8140&rft_id=info:doi/10.1083%2Fjcb.200805154 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2002 Jun 20;21(27):4191-9 [12082606] Genes Dev. 2002 Mar 1;16(5):571-82 [11877377] Nature. 2003 Jan 30;421(6922):499-506 [12556884] Nat Rev Cancer. 2003 Mar;3(3):155-68 [12612651] Nucleic Acids Res. 2003 Aug 1;31(15):e80 [12888532] EMBO J. 2003 Oct 15;22(20):5612-21 [14532133] EMBO J. 2003 Dec 15;22(24):6610-20 [14657032] Science. 2004 Apr 2;304(5667):93-6 [15064416] Cell. 1996 Jul 12;86(1):159-71 [8689683] Genes Dev. 1996 Oct 1;10(19):2411-22 [8843194] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13084-9 [8917548] Science. 1998 Sep 11;281(5383):1674-7 [9733514] Science. 1998 Sep 11;281(5383):1677-9 [9733515] Science. 1998 Dec 4;282(5395):1893-7 [9836640] Adv Immunol. 1999;72:179-89 [10361575] Oncogene. 1999 Jul 15;18(28):4047-54 [10435585] J Exp Med. 2004 Nov 1;200(9):1111-21 [15504820] J Exp Med. 2004 Nov 1;200(9):1103-10 [15520243] Science. 2005 Apr 22;308(5721):551-4 [15790808] Mol Cell Biol. 2005 Jul;25(13):5363-79 [15964794] Nat Cell Biol. 2005 Jul;7(7):675-85 [15965469] J Clin Pathol. 2005 Oct;58(10):1009-15 [16189143] Immunol Rev. 2006 Feb;209:142-58 [16448540] Mol Cell Biol. 2006 Mar;26(5):1691-9 [16478990] Nat Struct Mol Biol. 2006 May;13(5):451-7 [16622404] Nature. 2006 Jul 27;442(7101):466-70 [16799570] Nat Cell Biol. 2006 Aug;8(8):870-6 [16862143] EMBO J. 2006 Aug 9;25(15):3504-14 [16858402] Nature. 2006 Sep 14;443(7108):222-5 [16906133] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6323-8 [17405860] Science. 2007 May 25;316(5828):1160-6 [17525332] Nat Cell Biol. 2007 Jun;9(6):683-90 [17486112] J Exp Med. 2007 Jun 11;204(6):1371-81 [17502661] Cell. 2007 Jul 13;130(1):63-75 [17599403] Annu Rev Genomics Hum Genet. 2007;8:37-55 [17887919] Nat Cell Biol. 2007 Nov;9(11):1311-8 [17952060] Mol Cell Biol. 2007 Dec;27(24):8502-9 [17923702] Oncogene. 2007 Dec 10;26(56):7741-8 [18066086] Oncogene. 2007 Dec 10;26(56):7759-64 [18066088] Annu Rev Immunol. 2008;26:261-92 [18370922] J Biol Chem. 2001 Oct 12;276(41):38224-30 [11454856] Genes Dev. 2002 Mar 1;16(5):560-70 [11877376] Nat Cell Biol. 2002 Dec;4(12):993-7 [12447390] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1083/jcb.200805154 ER - TY - JOUR T1 - SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cells. AN - 69846388; 19047146 AB - The malignant transformation in several types of cancer, including lung cancer, results in a loss of growth inhibition by transforming growth factor-beta (TGF-beta). Here, we show that SMAD6 expression is associated with a reduced survival in lung cancer patients. Short hairpin RNA (shRNA)-mediated knockdown of SMAD6 in lung cancer cell lines resulted in reduced cell viability and increased apoptosis as well as inhibition of cell cycle progression. However, these results were not seen in Beas2B, a normal bronchial epithelial cell line. To better understand the mechanism underlying the association of SMAD6 with poor patient survival, we used a lentivirus construct carrying shRNA for SMAD6 to knock down expression of the targeted gene. Through gene expression analysis, we observed that knockdown of SMAD6 led to the activation of TGF-beta signaling through up-regulation of plasminogen activator inhibitor-1 and phosphorylation of SMAD2/3. Furthermore, SMAD6 knockdown activated the c-Jun NH2-terminal kinase pathway and reduced phosphorylation of Rb-1, resulting in increased G0-G1 cell arrest and apoptosis in the lung cancer cell line H1299. These results jointly suggest that SMAD6 plays a critical role in supporting lung cancer cell growth and survival. Targeted inactivation of SMAD6 may provide a novel therapeutic strategy for lung cancers expressing this gene. JF - Cancer research AU - Jeon, Hyo-Sung AU - Dracheva, Tatiana AU - Yang, Sei-Hoon AU - Meerzaman, Daoud AU - Fukuoka, Junya AU - Shakoori, Abbas AU - Shilo, Konstantin AU - Travis, William D AU - Jen, Jin AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 9686 EP - 9692 VL - 68 IS - 23 KW - RNA, Small Interfering KW - 0 KW - SMAD6 protein, human KW - Smad6 Protein KW - Transforming Growth Factor beta KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Phosphorylation KW - Down-Regulation KW - Cell Growth Processes -- physiology KW - Humans KW - Cell Cycle -- physiology KW - Apoptosis -- physiology KW - Transduction, Genetic KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - Immunohistochemistry KW - Signal Transduction KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Smad6 Protein -- genetics KW - Smad6 Protein -- biosynthesis KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- genetics KW - Transforming Growth Factor beta -- metabolism KW - Smad6 Protein -- deficiency KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69846388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=SMAD6+contributes+to+patient+survival+in+non-small+cell+lung+cancer+and+its+knockdown+reestablishes+TGF-beta+homeostasis+in+lung+cancer+cells.&rft.au=Jeon%2C+Hyo-Sung%3BDracheva%2C+Tatiana%3BYang%2C+Sei-Hoon%3BMeerzaman%2C+Daoud%3BFukuoka%2C+Junya%3BShakoori%2C+Abbas%3BShilo%2C+Konstantin%3BTravis%2C+William+D%3BJen%2C+Jin&rft.aulast=Jeon&rft.aufirst=Hyo-Sung&rft.date=2008-12-01&rft.volume=68&rft.issue=23&rft.spage=9686&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1083 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Genomics. 2007;8:98 [17425807] Cancer Res. 2007 Mar 1;67(5):2317-24 [17332363] N Engl J Med. 2000 May 4;342(18):1350-8 [10793168] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4820-5 [10781087] Nat Cell Biol. 2000 Apr;2(4):E65-7 [10783254] J Natl Cancer Inst. 2000 Sep 6;92(17):1388-402 [10974075] Cell. 2000 Oct 13;103(2):239-52 [11057897] J Cell Physiol. 2001 Jun;187(3):265-76 [11319750] Trends Cell Biol. 2001 Nov;11(11):S44-51 [11684442] J Cell Biol. 2001 Dec 10;155(6):1017-27 [11739411] Nature. 2002 Aug 8;418(6898):641-6 [12167862] Cancer Res. 2003 Nov 15;63(22):7760-8 [14633701] Mol Cell Biol. 2003 Dec;23(24):9081-93 [14645520] Clin Cancer Res. 2004 Jul 1;10(13):4314-24 [15240517] Cancer Biol Ther. 2004 Jul;3(7):667-75 [15197354] Proc Natl Acad Sci U S A. 1986 Apr;83(8):2438-42 [2871553] EMBO J. 1987 May;6(5):1281-6 [3111844] Science. 1988 Apr 8;240(4849):196-9 [2895499] Cancer Res. 1988 Jul 15;48(14):3898-904 [3164252] Cancer Res. 1996 Nov 1;56(21):4831-5 [8895728] J Biol Chem. 1997 Jan 17;272(3):1429-32 [8999807] Lung Cancer. 1996 Dec;16(1):47-59 [9017584] Cell. 1997 Jun 27;89(7):1165-73 [9215638] Nature. 1997 Oct 9;389(6651):622-6 [9335505] Nature. 1997 Oct 9;389(6651):631-5 [9335507] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10669-74 [9380693] Nature. 1997 Dec 4;390(6659):465-71 [9393997] Genes Dev. 1998 Jan 15;12(2):186-97 [9436979] EMBO J. 1998 Jun 1;17(11):3091-100 [9606191] Annu Rev Biochem. 1998;67:753-91 [9759503] Oncogene. 1998 Oct 1;17(13):1743-7 [9796704] Oncogene. 1999 May 20;18(20):3098-103 [10340381] Oncogene. 1999 Sep 23;18(39):5363-72 [10498890] Anticancer Res. 2004 Nov-Dec;24(6):3703-9 [15736400] J Natl Cancer Inst. 2005 Dec 7;97(23):1734-46 [16333029] J Biol Chem. 2006 Jul 21;281(29):20357-67 [16687405] Nat Immunol. 2006 Oct;7(10):1057-65 [16951688] Oncogene. 1999 Dec 2;18(51):7280-6 [10602482] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1083 ER - TY - JOUR T1 - Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma: a population-based analysis. AN - 69840096; 18823043 AB - Radiotherapy for Hodgkin lymphoma (HL) increases the risk of salivary gland carcinomas (SGC). To the authors' knowledge, however, the magnitude of the risk has not been assessed to date. The risks of SGC among 20,928 1-year survivors of HL who were diagnosed between 1973 and 2003 were evaluated in 11 population-based cancer registry areas of the Surveillance, Epidemiology, and End Results (SEER) program. Observed-to-expected ratios (O/E) were assessed by radiation treatment, sex, age at the time of HL diagnosis, calendar year of diagnosis, attained age, time since HL diagnosis, histologic type of SGC, and site of occurrence in the major salivary glands. Among 11,047 HL patients who received radiotherapy as part of their initial treatment for HL, 21 developed subsequent invasive SGC (O/E = 16.9; 95% confidence interval [95% CI], 10.4-25.8). The risk of radiation-related SGC was highest for younger HL patients (age <20 years) (O/E = 45.5; 95% CI, 12.4-116.5) and among 10-year survivors (O/E = 23.9; 95% CI, 13.1-40.1), with risks remaining elevated for at least 2 decades after irradiation. Significant differences in risk by histologic type were observed, with a particularly high risk of developing mucoepidermoid carcinomas (O = 14; O/E = 44.2 [95% CI, 24.2-74.2]) and adenocarcinomas (O = 4; O/E = 30.6 [95% CI, 8.3-78.2]) noted. HL patients treated with radiotherapy experienced a significantly increased risk of SGC, particularly when exposed at young ages or for at least 2 decades after exposure. Although the results of the current study reflect the late effects of former HL treatment approaches, they point to the importance of long-term follow-up and a heightened awareness of SGC risk in this population. (c) 2008 American Cancer Society JF - Cancer AU - Boukheris, Houda AU - Ron, Elaine AU - Dores, Graça M AU - Stovall, Marilyn AU - Smith, Susan A AU - Curtis, Rochelle E AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. boukherh@mail.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 3153 EP - 3159 VL - 113 IS - 11 SN - 0008-543X, 0008-543X KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Age Factors KW - Humans KW - SEER Program KW - Adult KW - Male KW - Female KW - Risk Assessment KW - Hodgkin Disease -- radiotherapy KW - Hodgkin Disease -- pathology KW - Salivary Gland Neoplasms -- etiology KW - Neoplasms, Second Primary -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69840096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Risk+of+radiation-related+salivary+gland+carcinomas+among+survivors+of+Hodgkin+lymphoma%3A+a+population-based+analysis.&rft.au=Boukheris%2C+Houda%3BRon%2C+Elaine%3BDores%2C+Gra%C3%A7a+M%3BStovall%2C+Marilyn%3BSmith%2C+Susan+A%3BCurtis%2C+Rochelle+E&rft.aulast=Boukheris&rft.aufirst=Houda&rft.date=2008-12-01&rft.volume=113&rft.issue=11&rft.spage=3153&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.23918 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-13 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Surg. 1978 Jun;135(6):820-4 [149506] Am J Surg. 1968 Oct;116(4):518-23 [4300240] Int J Epidemiol. 1984 Mar;13(1):112-5 [6698695] Am J Surg. 1984 Mar;147(3):345-8 [6703206] Cancer. 1984 Nov 1;54(9):1854-9 [6478421] Int J Cancer. 1987 May 15;39(5):571-85 [3570550] J Am Dent Assoc. 1990 Feb;120(2):151-8 [2405031] Ann Oncol. 1992 Sep;3 Suppl 4:117-28 [1450072] Blood. 1994 Jan 15;83(2):318-29 [8286731] Radiat Res. 1996 Jul;146(1):28-36 [8677295] N Engl J Med. 1997 Mar 27;336(13):897-904 [9070469] Cancer. 1997 Apr 15;79(8):1465-75 [9118025] J Clin Oncol. 1998 Feb;16(2):536-44 [9469338] Radiat Res. 1998 Jun;149(6):625-30 [9611101] Laryngoscope. 1998 Jul;108(7):1095-7 [9665263] Radiat Res. 2006 Jul;166(1 Pt 2):141-57 [16808603] Radiat Res. 2007 Jul;168(1):1-64 [17722996] N Engl J Med. 2007 Nov 8;357(19):1916-27 [17989384] N Engl J Med. 2007 Nov 8;357(19):1968-71 [17989391] J Clin Oncol. 2000 Jun;18(12):2435-43 [10856104] Br J Haematol. 2000 Sep;110(3):504-11 [10997959] J Clin Oncol. 2001 Nov 15;19(22):4238-44 [11709567] J Clin Oncol. 2002 Aug 15;20(16):3484-94 [12177110] Cancer. 2003 Aug 1;98(3):562-70 [12879474] Cancer J. 2003 Nov-Dec;9(6):467-71 [14740975] J Clin Oncol. 2004 Jul 15;22(14):2835-41 [15199092] Cancer. 1983 Jun 15;51(12):2159-63 [6850504] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.23918 ER - TY - JOUR T1 - Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures. AN - 69839991; 18845770 AB - Meconium analysis is a diagnostically sensitive and objective alternative to maternal self-report for detecting prenatal tobacco exposure. Nicotine and metabolite disposition in meconium is poorly characterized, and correlation of analytes' concentrations with neonatal outcomes is unexplored. Our objectives were to quantify nicotine, cotinine, trans-3'-hydroxycotinine (OH-cotinine), nornicotine, norcotinine, and glucuronide concentrations in meconium, identify the best biomarkers of in utero tobacco exposure, compare meconium concentrations of tobacco-exposed and nonexposed neonates, and investigate concentration-outcome relationships. We quantified concentrations of nicotine and 4 metabolites with and without hydrolysis simultaneously in meconium from tobacco-exposed and nonexposed neonates by liquid chromatography-tandem mass spectrometry. We compared meconium concentrations to birth weight, length, head circumference, gestational age, and 1- and 5-min Apgar scores. Nicotine, cotinine, and OH-cotinine were the most prevalent and abundant meconium tobacco biomarkers and were found in higher concentrations in tobacco-exposed neonates. Whereas cotinine and OH-cotinine are glucuronide bound, performing the lengthy and costly enzymatic hydrolysis identified only 1 additional positive specimen. Unconjugated nicotine, cotinine, or OH-cotinine meconium concentration >10 ng/g most accurately discriminated active from passive and nonexposed neonates. There was no significant correlation between quantitative nicotine and metabolite meconium results and neonatal outcomes, although presence of a nicotine biomarker predicted decreased head circumference. Unconjugated nicotine, cotinine, and OH-cotinine should be analyzed in meconium to detect in utero tobacco exposure, as approximately 25% of positive specimens did not contain cotinine. Immunoassay testing monitoring cotinine only would underestimate the prevalence of prenatal tobacco exposure. JF - Clinical chemistry AU - Gray, Teresa R AU - Magri, Raquel AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2018 EP - 2027 VL - 54 IS - 12 KW - Biomarkers KW - 0 KW - Glucuronates KW - Tobacco Smoke Pollution KW - nicotine N-glucuronide KW - 152306-59-7 KW - norcotinine KW - 17114-40-8 KW - hydroxycotinine KW - 27323-64-4 KW - Nicotine KW - 6M3C89ZY6R KW - nornicotine KW - 83H6L5QD8Z KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Cotinine -- analysis KW - Glucuronates -- analysis KW - Humans KW - Gestational Age KW - Infant, Newborn KW - Tandem Mass Spectrometry KW - Hydrolysis KW - Pregnancy KW - Apgar Score KW - Biomarkers -- analysis KW - Chromatography, Liquid KW - Cotinine -- analogs & derivatives KW - Female KW - Body Size KW - Maternal Exposure -- adverse effects KW - Maternal-Fetal Exchange KW - Nicotine -- metabolism KW - Meconium -- chemistry KW - Nicotine -- analysis KW - Nicotine -- adverse effects KW - Tobacco Smoke Pollution -- adverse effects KW - Nicotine -- analogs & derivatives KW - Smoking -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Meconium+nicotine+and+metabolites+by+liquid+chromatography-tandem+mass+spectrometry%3A+differentiation+of+passive+and+nonexposure+and+correlation+with+neonatal+outcome+measures.&rft.au=Gray%2C+Teresa+R%3BMagri%2C+Raquel%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Gray&rft.aufirst=Teresa&rft.date=2008-12-01&rft.volume=54&rft.issue=12&rft.spage=2018&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=1530-8561&rft_id=info:doi/10.1373%2Fclinchem.2008.109173 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-09 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Matern Child Health J. 1998 Jun;2(2):77-83 [10728263] Neonatology. 2008;94(2):75-8 [18212492] Chem Res Toxicol. 2003 Dec;16(12):1502-6 [14680362] Sao Paulo Med J. 2004 May 6;122(3):94-8 [15448806] Br J Obstet Gynaecol. 1987 Jul;94(7):678-81 [3620415] Arch Toxicol. 1988;62(5):395-7 [3242451] JAMA. 1993 Mar 24-31;269(12):1519-24 [8445814] J Pediatr. 1994 Mar;124(3):471-6 [8120724] Br J Obstet Gynaecol. 1996 Aug;103(8):806-13 [8760712] Addict Behav. 1996 Sep-Oct;21(5):675-9 [8876767] Clin Chem. 1997 Jan;43(1):180-1 [8990243] J Chromatogr B Biomed Sci Appl. 1998 Apr 10;707(1-2):317-21 [9613966] Am J Epidemiol. 1998 Aug 1;148(3):259-62 [9690362] Pharmacology. 1998 Aug;57(2):104-16 [9691230] Life Sci. 1998;63(26):2333-42 [9877223] Hum Exp Toxicol. 1999 Apr;18(4):283-90 [10333316] Forensic Sci Int. 1999 Jun 28;102(2-3):167-71 [10464932] Drug Metab Dispos. 2005 Jan;33(1):23-30 [15470160] East Mediterr Health J. 2004 Jan-Mar;10(1-2):96-105 [16201714] Paediatr Perinat Epidemiol. 2006 Mar;20(2):90-9 [16466427] Acta Obstet Gynecol Scand. 2006;85(11):1331-7 [17091413] BMC Public Health. 2007;7:81 [17506887] Hum Exp Toxicol. 2007 Jun;26(6):535-44 [17698949] Nicotine Tob Res. 2007 Oct;9(10):1005-13 [17852766] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):107-14 [18243821] Paediatr Perinat Epidemiol. 2008 Mar;22(2):162-71 [18298691] Pediatrics. 2008 Apr;121(4):e810-6 [18381510] Acta Obstet Gynecol Scand. 2002 Mar;81(3):240-4 [11966481] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1373/clinchem.2008.109173 ER - TY - JOUR T1 - Analysis of ordered categorical data: two score-independent approaches. AN - 69835239; 18266890 AB - A trend test is often employed to analyze ordered categorical data, in which a set of increasing scores is assigned a priori. There is a drawback in this approach, because how to choose a set of scores is not clear. There have been debates on which scores should be used (e.g., Graubard and Korn, 1987, Biometrics 43, 471-476; Ivanova and Berger, 2001, Biometrics 57, 567-570; Senn, 2007, Biometrics 63, 296-298). Conflicting conclusions are often obtained with different sets of scores. Two approaches, which have been applied to genetic case-control studies, are appealing for ordered categorical data, because they take into account the natural order in the data, are score independent, and not contingent on asymptotic theory. These two approaches are applied to a prospective study for detecting association between maternal drinking and congenital malformations. JF - Biometrics AU - Zheng, Gang AD - Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892-7913, USA. zhengg@nhlbi.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1276 EP - 1279 VL - 64 IS - 4 KW - Index Medicus KW - Maternal-Fetal Exchange KW - Mothers KW - Humans KW - Alcohol Drinking -- adverse effects KW - Statistics as Topic KW - Abnormalities, Multiple -- chemically induced KW - Female KW - Pregnancy KW - Biometry -- methods KW - Case-Control Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69835239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Analysis+of+ordered+categorical+data%3A+two+score-independent+approaches.&rft.au=Zheng%2C+Gang&rft.aulast=Zheng&rft.aufirst=Gang&rft.date=2008-12-01&rft.volume=64&rft.issue=4&rft.spage=1276&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=1541-0420&rft_id=info:doi/10.1111%2Fj.1541-0420.2008.00992.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1541-0420.2008.00992.x ER - TY - JOUR T1 - Treatment of high-risk chronic GVHD. AN - 69834100; 19041069 JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation AU - Pavletic, Steven AU - Vogelsand, Georgia B AD - National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1436 EP - 1437 VL - 14 IS - 12 KW - Immunosuppressive Agents KW - 0 KW - Steroids KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Tacrolimus -- adverse effects KW - Steroids -- adverse effects KW - Acute Disease KW - Transplantation Conditioning KW - Humans KW - Steroids -- administration & dosage KW - Transplantation, Homologous KW - Tacrolimus -- administration & dosage KW - Risk KW - Leukemia, Myeloid, Acute -- therapy KW - Peripheral Blood Stem Cell Transplantation KW - Drug Eruptions KW - Adult KW - Chronic Disease KW - Female KW - Male KW - Immunosuppressive Agents -- administration & dosage KW - Immunosuppressive Agents -- adverse effects KW - Graft vs Host Disease -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69834100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.atitle=Treatment+of+high-risk+chronic+GVHD.&rft.au=Pavletic%2C+Steven%3BVogelsand%2C+Georgia+B&rft.aulast=Pavletic&rft.aufirst=Steven&rft.date=2008-12-01&rft.volume=14&rft.issue=12&rft.spage=1436&rft.isbn=&rft.btitle=&rft.title=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.issn=1523-6536&rft_id=info:doi/10.1016%2Fj.bbmt.2008.05.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-10 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbmt.2008.05.016 ER - TY - JOUR T1 - Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival. AN - 69834011; 18710444 AB - To determine if the C421A single nucleotide polymorphism (SNP) in the ATP-binding cassette transporter ABCG2 increases prostate cancer risk or affects survival. Numerous studies have suggested that dietary, hormonal and environmental factors all play a role in the initiation in prostate cancer; among these, the carcinogenic heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a known substrate of the ABCG2. A SNP of ABCG2, C421A, resulting in a glutamine to lysine change at amino acid 141, has been shown to result in decreased function of the protein. Due to the expression of ABCG2 in the prostate, together with the purported role of dietary carcinogens and steroids in the development and progression of prostate cancer, 311 individuals were genotyped for the ABCG2 C421A SNP, 170 patients with androgen-independent prostate cancer (AIPC) and 141 'healthy' controls. We also evaluated the effect of this SNP on the intracellular accumulation of PhIP and testosterone in vitro. There were no significant differences in the prevalence of prostate cancer based on ABCG2 genetic variation in this population. However, survival was significantly longer for individuals with wild-type ABCG2, as compared with those hetero- or homozygous for the C421A SNP (7.4 years vs 5.3 years, P = 0.044). Intracellular accumulation of PhIP was 80% higher in HEK293 cells transfected with Q141K ABCG2 than in wild-type cells, confirming that this SNP decreases transport of PhIP. In contrast, testosterone was not transported by either wild-type or variant transfected cells, nor did it act as in inhibitor of ABCG2 in subsequent transport assays. Increased exposure to PhIP may decrease survival, but the ABCG2 C421A polymorphism does not appear to increase the risk of prostate cancer. JF - BJU international AU - Gardner, Erin R AU - Ahlers, Christoph M AU - Shukla, Suneet AU - Sissung, Tristan M AU - Ockers, Sandra B AU - Price, Douglas K AU - Hamada, Akinobu AU - Robey, Robert W AU - Steinberg, Seth M AU - Ambudkar, Suresh V AU - Dahut, William L AU - Figg, William D AD - Clinical Pharmacology Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1694 EP - 1699 VL - 102 IS - 11 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Androgens KW - Neoplasm Proteins KW - Index Medicus KW - Humans KW - Aged KW - Cell Line, Tumor KW - Polymerase Chain Reaction KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Mutation -- genetics KW - Middle Aged KW - Diet KW - Androgens -- metabolism KW - Male KW - Prostatic Neoplasms -- mortality KW - ATP-Binding Cassette Transporters -- metabolism KW - Prostatic Neoplasms -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69834011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BJU+international&rft.atitle=Association+of+the+ABCG2+C421A+polymorphism+with+prostate+cancer+risk+and+survival.&rft.au=Gardner%2C+Erin+R%3BAhlers%2C+Christoph+M%3BShukla%2C+Suneet%3BSissung%2C+Tristan+M%3BOckers%2C+Sandra+B%3BPrice%2C+Douglas+K%3BHamada%2C+Akinobu%3BRobey%2C+Robert+W%3BSteinberg%2C+Seth+M%3BAmbudkar%2C+Suresh+V%3BDahut%2C+William+L%3BFigg%2C+William+D&rft.aulast=Gardner&rft.aufirst=Erin&rft.date=2008-12-01&rft.volume=102&rft.issue=11&rft.spage=1694&rft.isbn=&rft.btitle=&rft.title=BJU+international&rft.issn=1464-410X&rft_id=info:doi/10.1111%2Fj.1464-410X.2008.07913.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2004 Sep 1;10(17):5889-94 [15355921] Clin Pharmacol Ther. 2004 Jul;76(1):38-44 [15229462] Cancer Res. 1997 Jan 15;57(2):195-8 [9000552] Pharm Res. 2004 Oct;21(10):1895-903 [15553238] Pharmacogenomics. 2005 Mar;6(2):115-38 [15882131] Cancer Chemother Pharmacol. 2005 Aug;56(2):161-72 [15838659] Cancer Res. 2005 Aug 1;65(15):6640-50 [16061644] Cancer Res. 2005 Sep 1;65(17):8034-41 [16140978] Cancer Res. 2005 Dec 15;65(24):11779-84 [16357191] J Androl. 2006 Mar-Apr;27(2):138-50 [16330661] Cancer Lett. 2006 Apr 8;235(1):84-92 [15990223] Invest New Drugs. 2006 Sep;24(5):393-401 [16505951] Biochemistry. 2006 Jul 25;45(29):8940-51 [16846237] Clin Pharmacol Ther. 2006 Aug;80(2):192-201 [16890580] Physiol Rev. 2006 Oct;86(4):1179-236 [17015488] Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6094-9 [17062685] Pharmacol Ther. 2006 Nov;112(2):457-73 [16766035] Cancer Metastasis Rev. 2007 Mar;26(1):39-57 [17323127] BMC Urol. 2007;7:6 [17425799] Mol Cancer Ther. 2007 Jun;6(6):1877-85 [17575116] Mol Pharmacol. 2008 Jan;73(1):12-7 [18094074] Clin Cancer Res. 2001 Jan;7(1):145-52 [11205902] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62 [11352869] J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):155-68 [11477514] Prostate. 2002 Aug 1;52(3):213-35 [12111697] Mol Cancer Ther. 2002 Jun;1(8):611-6 [12479221] J Biol Chem. 2003 Jun 6;278(23):20645-51 [12668685] Cancer Res. 2003 Oct 1;63(19):6447-52 [14559835] Br J Cancer. 2003 Nov 17;89(10):1971-8 [14612912] Int J Cancer. 2004 Mar 20;109(2):238-46 [14750175] J Biol Chem. 2004 May 7;279(19):19781-9 [15001581] Carcinogenesis. 1991 Aug;12(8):1503-6 [1860171] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1464-410X.2008.07913.x ER - TY - JOUR T1 - Reperfusion-associated hemorrhagic transformation in SHR rats: evidence of symptomatic parenchymal hematoma. AN - 69828615; 18757286 AB - Symptomatic hemorrhagic transformation (HT) is the most important complicating factor after treatment with intravenous tissue plasminogen activator. In this study, we used multimodal magnetic resonance imaging to investigate the incidence and severity of reperfusion-based HT in spontaneously hypertensive rats after ischemia/reperfusion. Twenty male spontaneously hypertensive rats were subjected to 30 minutes of middle cerebral artery occlusion via the suture model. Diffusion-weighted, T(2)-weighted, and gradient-echo imaging were performed on days 1, 2, 3, 4, and 7 for longitudinal evaluation of lesion evolution, vasogenic edema, and HT, respectively. Findings on gradient-echo images were classified according to the severity of hemorrhage: no HT; punctate or small petechial hemorrhage (HI-1); confluent petechial hemorrhage (HI-2); hematoma with absent/mild space-occupying effect (PH-1, 30% lesion volume). Histopathologic evaluation of HT was performed after final imaging for comparison with magnetic resonance imaging results. Final hemorrhage scores based on severity were as follows: HI-1 23.1%, HI-2 30.8%, PH-1 30.8%, and PH-2 15.4%. Similar to clinical observations, only PH-2 was associated with neurologic deterioration and associated weight loss. This model has a high incidence of parenchymal hematomas (46.2%) and therefore is appropriate for the evaluation of novel therapeutics targeting blood-brain barrier integrity and the reduction of symptomatic HT events (PH-2), as well as those potentially "at risk" for neurologic deterioration (PH-1). JF - Stroke AU - Henning, Erica C AU - Latour, Lawrence L AU - Hallenbeck, John M AU - Warach, Steven AD - Section on Stroke Diagnostics and Therapeutics, Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. henninge@ninds.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3405 EP - 3410 VL - 39 IS - 12 KW - Fibrinolytic Agents KW - 0 KW - Recombinant Proteins KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Rats, Inbred SHR KW - Disease Progression KW - Hypertension -- genetics KW - Recombinant Proteins -- toxicity KW - Blood-Brain Barrier -- drug effects KW - Hypertension -- complications KW - Rats KW - Brain Edema -- etiology KW - Weight Loss KW - Movement Disorders -- etiology KW - Time Factors KW - Male KW - Recombinant Proteins -- therapeutic use KW - Fibrinolytic Agents -- therapeutic use KW - Cerebral Hemorrhage -- chemically induced KW - Infarction, Middle Cerebral Artery -- complications KW - Hematoma -- etiology KW - Hematoma -- pathology KW - Fibrinolytic Agents -- toxicity KW - Tissue Plasminogen Activator -- therapeutic use KW - Infarction, Middle Cerebral Artery -- pathology KW - Tissue Plasminogen Activator -- toxicity KW - Cerebral Hemorrhage -- pathology KW - Infarction, Middle Cerebral Artery -- drug therapy KW - Thrombolytic Therapy -- adverse effects KW - Reperfusion Injury -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69828615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Reperfusion-associated+hemorrhagic+transformation+in+SHR+rats%3A+evidence+of+symptomatic+parenchymal+hematoma.&rft.au=Henning%2C+Erica+C%3BLatour%2C+Lawrence+L%3BHallenbeck%2C+John+M%3BWarach%2C+Steven&rft.aulast=Henning&rft.aufirst=Erica&rft.date=2008-12-01&rft.volume=39&rft.issue=12&rft.spage=3405&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=1524-4628&rft_id=info:doi/10.1161%2FSTROKEAHA.108.520304 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1161/STROKEAHA.108.520304 ER - TY - JOUR T1 - Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans. AN - 69824937; 18945689 AB - Despite the belief that the etiology of and risk factors for rectal cancer might differ from those for colon cancer, relatively few studies have examined rectal cancer in relation to use of nonsteroidal antiinflammatory drugs (NSAIDs). The authors evaluated the association between NSAIDs and distal large bowel cancer in African Americans and whites, using data from a population-based case-control study of 1,057 incident cases of adenocarcinoma of the sigmoid colon, rectosigmoid junction, and rectum and 1,019 controls from North Carolina (2001-2006). NSAID use was inversely associated with distal large bowel cancer in whites (odds ratio (OR) = 0.60, 95% confidence interval (CI): 0.46, 0.79). The inverse association was evident for all types of NSAIDs but was slightly stronger with prescription NSAIDs, particularly selective cyclooxygenase 2 inhibitors (OR = 0.38, 95% CI: 0.25, 0.56). Compared with whites, a relatively weak inverse association was found in African Americans (OR = 0.87, 95% CI: 0.55, 1.40), although odds ratio heterogeneity by race could not be confirmed (P = 0.21). In addition, the strength of the association with NSAIDs varied by tumor location, suggesting more potent effects for rectal and rectosigmoid cancers than for sigmoid cancer. The chemopreventive potential of NSAIDs might differ by population and by tumor characteristics. JF - American journal of epidemiology AU - Kim, Sangmi AU - Martin, Christopher AU - Galanko, Joseph AU - Woosley, John T AU - Schroeder, Jane C AU - Keku, Temitope O AU - Satia, Jessie A AU - Halabi, Susan AU - Sandler, Robert S AD - Epidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Kims3@niehs.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 1292 EP - 1300 VL - 168 IS - 11 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - North Carolina -- epidemiology KW - Male KW - Female KW - Cyclooxygenase 2 Inhibitors -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cyclooxygenase 2 Inhibitors -- therapeutic use KW - African Americans -- statistics & numerical data KW - European Continental Ancestry Group -- statistics & numerical data KW - Colorectal Neoplasms -- epidemiology KW - Colorectal Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69824937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Use+of+nonsteroidal+antiinflammatory+drugs+and+distal+large+bowel+cancer+in+whites+and+African+Americans.&rft.au=Kim%2C+Sangmi%3BMartin%2C+Christopher%3BGalanko%2C+Joseph%3BWoosley%2C+John+T%3BSchroeder%2C+Jane+C%3BKeku%2C+Temitope+O%3BSatia%2C+Jessie+A%3BHalabi%2C+Susan%3BSandler%2C+Robert+S&rft.aulast=Kim&rft.aufirst=Sangmi&rft.date=2008-12-01&rft.volume=168&rft.issue=11&rft.spage=1292&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn255 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-22 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 1998 Jun 15;82(12):2326-33 [9635524] Br J Cancer. 1997;76(5):675-7 [9303370] Arch Intern Med. 1999 Jan 25;159(2):161-6 [9927099] N Engl J Med. 1999 Jun 17;340(24):1888-99 [10369853] J Am Geriatr Soc. 1999 Jun;47(6):749-54 [10366179] Br J Cancer. 1999 Sep;81(1):62-8 [10487613] Gut. 1999 Nov;45(5):730-2 [10517910] J Surg Oncol. 2004 Dec 15;88(4):261-6 [15565587] JAMA. 2005 Jul 6;294(1):47-55 [15998890] Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1613-8 [16030091] Am J Epidemiol. 2005 Sep 15;162(6):548-58 [16093288] Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):494-501 [16537707] Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1785-90 [17035383] Ann Intern Med. 2007 Mar 6;146(5):365-75 [17339622] N Engl J Med. 2007 May 24;356(21):2131-42 [17522398] Cancer Causes Control. 2000 Mar;11(3):249-55 [10782659] BMJ. 2000 Jun 17;320(7250):1642-6 [10856067] Clin Infect Dis. 2000 Oct;31 Suppl 5:S202-10 [11113024] Curr Opin Oncol. 2001 Jan;13(1):63-9 [11148689] Annu Rev Pharmacol Toxicol. 2002;42:55-80 [11807164] J Natl Cancer Inst. 2002 Feb 20;94(4):252-66 [11854387] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1305-15 [12433707] Gastroenterology. 2002 Dec;123(6):1770-7 [12454832] Ann Pharmacother. 2003 Jan;37(1):136-42 [12503949] N Engl J Med. 2003 Mar 6;348(10):883-90 [12621132] N Engl J Med. 2003 Mar 6;348(10):891-9 [12621133] Int J Gastrointest Cancer. 2002;31(1-3):147-54 [12622426] Pharmacoepidemiol Drug Saf. 2003 Jun;12(4):315-26 [12812012] Lancet Oncol. 2003 Oct;4(10):605-15 [14554238] Cancer Lett. 2004 Nov 8;215(1):1-20 [15374627] Am J Epidemiol. 1991 Aug 15;134(4):421-32 [1877602] Med Sci Sports Exerc. 1993 Jan;25(1):71-80 [8292105] J Natl Cancer Inst. 1993 Aug 4;85(15):1220-4 [8331682] Cancer. 1993 Aug 15;72(4):1171-7 [8339210] Arch Intern Med. 1994 Feb 28;154(4):394-9 [8117171] Ann Intern Med. 1994 Aug 15;121(4):241-6 [8037405] Cancer. 1994 Oct 1;74(7):1847-54 [8082089] Breast Cancer Res Treat. 1995 Jul;35(1):61-4 [7612905] N Engl J Med. 1995 Sep 7;333(10):609-14 [7637720] Am J Epidemiol. 1995 Nov 15;142(10):1103-12 [7485055] Cancer Epidemiol Biomarkers Prev. 1996 Dec;5(12):955-60 [8959316] Cancer. 1997 Feb 1;79(3):441-7 [9028352] Cancer. 1997 Jul 15;80(2):193-7 [9217029] J Natl Cancer Inst. 1998 Nov 4;90(21):1609-20 [9811310] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn255 ER - TY - JOUR T1 - A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. AN - 69817957; 18669595 AB - Low-molecular-weight (LMW) antagonists for TSH receptor (TSHR) may have therapeutic potential as orally active drugs to block stimulating antibodies (TsAbs) in Graves' hyperthyroidism. We describe an approach to identify LMW ligands for TSHR based on Org41841, a LMW partial agonist for the LH/choriogonadotropin receptor and TSHR. We used molecular modeling and functional experiments to guide the chemical modification of Org41841. We identified an antagonist (NIDDK/CEB-52) that selectively inhibits activation of TSHR by both TSH and TsAbs. Whereas initially characterized in cultured cells overexpressing TSHRs, the antagonist was also active under more physiologically relevant conditions in primary cultures of human thyrocytes expressing endogenous TSHRs in which it inhibited TSH- and TsAb-induced up-regulation of mRNA transcripts for thyroperoxidase. Our results establish this LMW compound as a lead for the development of higher potency antagonists and serve as proof of principle that LMW ligands that target TSHR could serve as drugs in patients with Graves' disease. JF - Endocrinology AU - Neumann, Susanne AU - Kleinau, Gunnar AU - Costanzi, Stefano AU - Moore, Susanna AU - Jiang, Jian-kang AU - Raaka, Bruce M AU - Thomas, Craig J AU - Krause, Gerd AU - Gershengorn, Marvin C AD - National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Endocrinology Branch, National Institutes of Health, 50 South Drive, Bethesda, Maryland 20892-8029, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 5945 EP - 5950 VL - 149 IS - 12 SN - 0013-7227, 0013-7227 KW - Antithyroid Agents KW - 0 KW - Receptors, Thyrotropin KW - Abridged Index Medicus KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Molecular Structure KW - Computer Simulation KW - Cells, Cultured KW - Humans KW - Protein Binding -- genetics KW - Molecular Weight KW - Cell Line KW - Receptors, Thyrotropin -- metabolism KW - Hyperthyroidism -- drug therapy KW - Antithyroid Agents -- chemical synthesis KW - Hyperthyroidism -- metabolism KW - Receptors, Thyrotropin -- antagonists & inhibitors KW - Antithyroid Agents -- pharmacology KW - Receptors, Thyrotropin -- genetics KW - Antithyroid Agents -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69817957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=A+low-molecular-weight+antagonist+for+the+human+thyrotropin+receptor+with+therapeutic+potential+for+hyperthyroidism.&rft.au=Neumann%2C+Susanne%3BKleinau%2C+Gunnar%3BCostanzi%2C+Stefano%3BMoore%2C+Susanna%3BJiang%2C+Jian-kang%3BRaaka%2C+Bruce+M%3BThomas%2C+Craig+J%3BKrause%2C+Gerd%3BGershengorn%2C+Marvin+C&rft.aulast=Neumann&rft.aufirst=Susanne&rft.date=2008-12-01&rft.volume=149&rft.issue=12&rft.spage=5945&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/10.1210%2Fen.2008-0836 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Biochem Sci. 2004 Mar;29(3):119-26 [15003269] Chembiochem. 2002 Oct 4;3(10):928-44 [12362358] J Mol Biol. 1993 Jun 20;231(4):1049-67 [8515464] J Virol. 1998 Jan;72(1):279-85 [9420225] J Biol Chem. 1999 Apr 2;274(14):9617-26 [10092648] Nature. 2005 Jan 20;433(7023):269-77 [15662415] Drug Discov Today. 2005 Jul 1;10(13):895-907 [15993809] Mol Pharmacol. 2005 Nov;68(5):1271-80 [16099840] J Biol Chem. 2006 Apr 14;281(15):9841-4 [16488885] J Med Chem. 2006 Jun 29;49(13):3888-96 [16789744] Drug Discov Today. 2006 Jul;11(13-14):580-94 [16793526] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8 [17060607] J Biol Chem. 2007 Jan 5;282(1):518-25 [17079233] Curr Top Med Chem. 2007;7(10):1006-14 [17508934] J Comput Aided Mol Des. 2007 Aug;21(8):437-53 [17668276] J Mol Biol. 2007 Oct 5;372(5):1179-88 [17825322] ChemMedChem. 2007 Oct;2(10):1388-401 [17806089] Nature. 2007 Nov 15;450(7168):383-7 [17952055] Science. 2007 Nov 23;318(5854):1258-65 [17962520] J Biomol Screen. 2008 Feb;13(2):120-7 [18216391] Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11304-9 [15277683] Science. 2000 Aug 4;289(5480):739-45 [10926528] Virology. 2001 Sep 1;287(2):382-90 [11531415] Physiol Rev. 2002 Apr;82(2):473-502 [11917095] J Med Chem. 2002 Apr 11;45(8):1712-22 [11931626] Endocr Rev. 2002 Apr;23(2):141-74 [11943741] Comment In: Endocrinology. 2008 Dec;149(12):5943-4 [19022900] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2008-0836 ER - TY - JOUR T1 - Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers. AN - 69814129; 18799724 AB - Graft-versus-tumor effects can be achieved after allogeneic bone marrow transplantation in patients with malignancies of the kidney or hematopoietic system but are often accompanied by severe graft-versus-host-disease (GVHD). We sought to maximize graft-versus-tumor while minimizing GVHD using tumor-specific allogeneic effector T cells rather than open-repertoire T cells. We transferred allogeneic CD8(+) pmel-1 or CD4(+) TRP-1 T cells specific for the melanoma-associated antigens, glycoprotein 100 (gp100) and tyrosinase-related protein-1 (TRP-1), respectively, into B16-melanoma-bearing mice. Mice receiving a preparative regimen of nonmyeloablating (5 Gy) total body irradiation experienced the rapid rejection of tumor-specific allogeneic lymphocytes with no impact on tumor growth. However, when mice were given more intense total body irradiation conditioning regimens combined with autologous bone marrow transplantation, adoptively transferred allogeneic tumor-specific T lymphocytes persisted at detectable levels for several weeks and mediated significant regression of large, vascularized tumors. We found that the risk of GVHD was low when tumor-specific T cells were transferred and significant toxicity was observed only when substantial numbers of open repertoire allogeneic naive T cells were mixed with the tumor-specific lymphocytes. Taken together, these data indicate that the use of tumor-specific allogeneic CD8(+) T cells or CD4(+) can result in significant antitumor effects in the absence of measurable GVHD. JF - Blood AU - Boni, Andrea AU - Muranski, Pawel AU - Cassard, Lydie AU - Wrzesinski, Claudia AU - Paulos, Chrystal M AU - Palmer, Douglas C AU - Gattinoni, Luca AU - Hinrichs, Christian S AU - Chan, Chi-Chao AU - Rosenberg, Steven A AU - Restifo, Nicholas P AD - Clinical Research Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 4746 EP - 4754 VL - 112 IS - 12 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Transplantation, Homologous -- physiology KW - Graft vs Host Disease -- immunology KW - Graft vs Tumor Effect -- immunology KW - Mice KW - Mice, Transgenic KW - Graft vs Host Disease -- prevention & control KW - Melanoma, Experimental -- pathology KW - Mice, Inbred BALB C KW - Melanoma, Experimental -- immunology KW - Melanoma, Experimental -- therapy KW - Mice, Inbred DBA KW - Graft vs Tumor Effect -- genetics KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Remission Induction -- methods KW - Transplantation, Homologous -- immunology KW - Female KW - Lymphocytes, Tumor-Infiltrating -- physiology KW - Lymphocytes, Tumor-Infiltrating -- immunology KW - Blood Group Incompatibility -- genetics KW - Adoptive Transfer -- methods KW - Blood Group Incompatibility -- immunology KW - Major Histocompatibility Complex -- physiology KW - Tumor Burden -- immunology KW - Lymphocytes, Tumor-Infiltrating -- transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69814129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Adoptive+transfer+of+allogeneic+tumor-specific+T+cells+mediates+effective+regression+of+large+tumors+across+major+histocompatibility+barriers.&rft.au=Boni%2C+Andrea%3BMuranski%2C+Pawel%3BCassard%2C+Lydie%3BWrzesinski%2C+Claudia%3BPaulos%2C+Chrystal+M%3BPalmer%2C+Douglas+C%3BGattinoni%2C+Luca%3BHinrichs%2C+Christian+S%3BChan%2C+Chi-Chao%3BRosenberg%2C+Steven+A%3BRestifo%2C+Nicholas+P&rft.aulast=Boni&rft.aufirst=Andrea&rft.date=2008-12-01&rft.volume=112&rft.issue=12&rft.spage=4746&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-07-169797 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-12 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bone Marrow Transplant. 2005 Jun;35(12):1127-32 [15834432] J Immunother. 2005 Jul-Aug;28(4):281-8 [16000944] Cancer Immunol Immunother. 2005 Aug;54(8):721-8 [16010587] Lancet. 2005 Jul 23-29;366(9482):318-20 [16039336] J Exp Med. 2005 Oct 3;202(7):907-12 [16203864] J Immunother. 2005 Nov-Dec;28(6):517-24 [16224268] J Immunol. 2005 Nov 15;175(10):7046-52 [16272366] Nat Rev Immunol. 2006 May;6(5):383-93 [16622476] Nature. 2006 Apr 27;440(7088):1123 [16641981] Immunol Rev. 2006 Jun;211:214-24 [16824130] Immunol Rev. 2008 Jun;223:334-60 [18613846] J Cell Mol Med. 2009 Aug;13(8B):1962-76 [18624776] Bone Marrow Transplant. 2003 May;31(10):943-5 [12748675] J Clin Invest. 2003 Jul;112(1):101-8 [12840064] J Immunother. 2003 Jul-Aug;26(4):332-42 [12843795] J Exp Med. 2003 Aug 18;198(4):569-80 [12925674] Science. 2003 Oct 17;302(5644):415-9 [14564000] Transfusion. 2003 Dec;43(12):1667-71 [14641861] Annu Rev Med. 2004;55:459-75 [14746531] Nat Clin Pract Oncol. 2008 May;5(5):256-67 [18398414] N Engl J Med. 2000 Sep 14;343(11):750-8 [10984562] Cancer Immunol Immunother. 2001 Mar;50(1):3-15 [11315507] J Clin Oncol. 2002 Apr 15;20(8):2017-24 [11956260] Bone Marrow Transplant. 2002 Jul;30(2):95-102 [12132048] Lancet. 2002 Aug 10;360(9331):436-42 [12241714] N Engl J Med. 2003 Jan 16;348(3):255-6 [12529469] Nature. 2003 Feb 20;421(6925):852-6 [12594515] Bone Marrow Transplant. 2003 Feb;31(4):253-61 [12621459] Science. 2003 Apr 11;300(5617):337-9 [12690201] Blood. 2004 Feb 15;103(4):1534-41 [14551132] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1969-74 [14762166] Pancreas. 2004 Apr;28(3):e65-9 [15084986] J Clin Oncol. 2004 Oct 1;22(19):3886-92 [15314059] Nat Immunol. 2004 Nov;5(11):1143-8 [15475958] Blood. 1992 Jul 15;80(2):551-5 [1627807] Blood. 1995 Mar 1;85(5):1207-14 [7858251] J Exp Med. 1996 Mar 1;183(3):725-9 [8642276] Lancet. 1996 Aug 17;348(9025):472-3 [8709796] Ann Surg Oncol. 1996 Jan;3(1):67-73 [8770305] J Immunol. 1996 Dec 1;157(11):4811-21 [8943383] J Exp Med. 1998 Mar 2;187(5):693-702 [9480979] Hum Gene Ther. 2005 Jan;16(1):35-48 [15703487] Immunity. 2005 Mar;22(3):371-83 [15780993] Blood. 2006 Sep 15;108(6):1797-808 [16741253] Nat Clin Pract Oncol. 2006 Dec;3(12):668-81 [17139318] J Clin Invest. 2007 Feb;117(2):492-501 [17273561] Gene Ther. 2007 Mar;14(6):491-502 [17203106] Front Biosci. 2007;12:2922-34 [17485269] Blood. 2007 Jun 15;109(12):5168-77 [17353346] J Clin Invest. 2007 Aug;117(8):2197-204 [17657310] Blood. 2007 Aug 15;110(4):1123-31 [17468341] J Control Release. 2007 Sep 11;122(1):102-10 [17628160] Curr Opin Hematol. 2007 Nov;14(6):616-24 [17898565] Blood. 2007 Oct 15;110(8):2793-802 [17638856] Hematology Am Soc Hematol Educ Program. 2007;:460-5 [18024665] Nat Rev Immunol. 2007 Dec;7(12):942-53 [18007679] Semin Immunol. 2007 Oct;19(5):318-30 [18023361] J Immunol. 2008 Mar 1;180(5):3122-31 [18292535] Nat Rev Cancer. 2008 Apr;8(4):299-308 [18354418] Nat Biotechnol. 2008 Apr;26(4):453-61 [18376399] Blood. 2008 Apr 15;111(8):4392-402 [17878399] Biol Blood Marrow Transplant. 2008 May;14(5):518-30 [18410894] Exp Hematol. 2000 Nov;28(11):1225-31 [11063870] Trends Immunol. 2008 May;29(5):235-41 [18375183] Immunol Cell Biol. 2008 May-Jun;86(4):312-9 [18362947] Blood. 2008 May 15;111(10):5242-51 [18285547] Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8061-6 [18523011] J Immunol. 2008 Jul 1;181(1):165-73 [18566381] N Engl J Med. 2008 Jun 19;358(25):2698-703 [18565862] Blood. 2008 Jul 15;112(2):362-73 [18354038] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] J Immunother. 2005 May-Jun;28(3):258-67 [15838383] Lancet Oncol. 2005 May;6(5):344-6 [15863383] J Clin Invest. 2005 Jun;115(6):1616-26 [15931392] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-07-169797 ER - TY - JOUR T1 - A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. AN - 69806245; 18799805 AB - Cytochrome P450 3A4 (CYP3A4), the most abundant human cytochrome P450 in liver, participates in the metabolism of approximately 50% of clinically used drugs. The pregnane X receptor (PXR), a member of the nuclear receptor superfamily, is the major activator of CYP3A4 transcription. However, because of species differences in response to PXR ligands, it is problematic to use rodents to assess CYP3A4 regulation and function. The generation of double transgenic mice expressing human PXR and CYP3A4 (TgCYP3A4/hPXR) would provide a solution to this problem. In the current study, a TgCYP3A4/hPXR mouse model was generated by bacterial artificial chromosome transgenesis in Pxr-null mice. In TgCYP3A4/hPXR mice, CYP3A4 was strongly induced by rifampicin, a human-specific PXR ligand, but not by pregnenolone 16alpha-carbonitrile, a rodent-specific PXR ligand. Consistent with CYP3A expression, hepatic CYP3A activity increased approximately 5-fold in TgCYP3A4/hPXR mice pretreated with rifampicin. Most antihuman immunodeficiency virus protease inhibitors are CYP3A substrates and their interactions with rifamycins are a source of major concern in patients coinfected with human immunodeficiency virus and Mycobacterium tuberculosis. By using TgCYP3A4/hPXR mice, human PXR-CYP3A4-mediated rifampicin-protease inhibitor interactions were recapitulated, as the metabolic stability of amprenavir, nelfinavir, and saquinavir decreased 52, 53, and 99%, respectively, in the liver microsomes of TgCYP3A4/hPXR mice pretreated with rifampicin. In vivo, rifampicin pretreatment resulted in an approximately 80% decrease in the area under the serum amprenavir concentration-time curve in TgCYP3A4/hPXR mice. These results suggest that the TgCYP3A4/hPXR mouse model could serve as a useful tool for studies on CYP3A4 transcription and function in vivo. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Ma, Xiaochao AU - Cheung, Connie AU - Krausz, Kristopher W AU - Shah, Yatrik M AU - Wang, Ting AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2506 EP - 2512 VL - 36 IS - 12 KW - Carbamates KW - 0 KW - Cytochrome P-450 Enzyme Inhibitors KW - HIV Protease Inhibitors KW - Receptors, Steroid KW - Sulfonamides KW - pregnane X receptor KW - Pregnenolone Carbonitrile KW - 1434-54-4 KW - amprenavir KW - 5S0W860XNR KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - CYP3A protein, mouse KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP3A KW - Nelfinavir KW - HO3OGH5D7I KW - Saquinavir KW - L3JE09KZ2F KW - Ketoconazole KW - R9400W927I KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Sex Characteristics KW - Humans KW - Microsomes, Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Liver -- metabolism KW - Carbamates -- pharmacokinetics KW - Mice, Transgenic KW - Mice, Knockout KW - Carbamates -- metabolism KW - Liver -- drug effects KW - Microsomes, Liver -- drug effects KW - HIV Protease Inhibitors -- pharmacokinetics KW - Intestine, Small -- drug effects KW - Ketoconazole -- pharmacology KW - Male KW - Pregnenolone Carbonitrile -- pharmacology KW - Intestine, Small -- metabolism KW - Mice KW - Drug Interactions -- physiology KW - Nelfinavir -- metabolism KW - Sulfonamides -- pharmacokinetics KW - Sulfonamides -- metabolism KW - Gene Expression Regulation -- physiology KW - Rifampin -- pharmacology KW - Saquinavir -- metabolism KW - Female KW - HIV Protease Inhibitors -- metabolism KW - Models, Animal KW - Cytochrome P-450 CYP3A -- metabolism KW - Receptors, Steroid -- genetics KW - Cytochrome P-450 CYP3A -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69806245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=A+double+transgenic+mouse+model+expressing+human+pregnane+X+receptor+and+cytochrome+P450+3A4.&rft.au=Ma%2C+Xiaochao%3BCheung%2C+Connie%3BKrausz%2C+Kristopher+W%3BShah%2C+Yatrik+M%3BWang%2C+Ting%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Ma&rft.aufirst=Xiaochao&rft.date=2008-12-01&rft.volume=36&rft.issue=12&rft.spage=2506&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.108.022723 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-05 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Drug Metab. 2004 Dec;5(6):483-505 [15578943] J Pharmacol Exp Ther. 1994 Oct;271(1):549-56 [7965755] Curr Drug Metab. 2005 Aug;6(4):357-67 [16101574] Annu Rev Pharmacol Toxicol. 2006;46:41-64 [16402898] J Pharmacol Exp Ther. 2006 Mar;316(3):1328-34 [16291874] Trop Doct. 2006 Apr;36(2):73-9 [16611437] Drugs. 2006;66(18):2299-308 [17181373] Drug Metab Dispos. 2007 Feb;35(2):194-200 [17093002] Curr Drug Metab. 2007 Feb;8(2):185-94 [17305497] J Antimicrob Chemother. 2007 Apr;59(4):690-7 [17307771] Mol Endocrinol. 2000 Jan;14(1):27-39 [10628745] Nature. 2000 Jul 27;406(6794):435-9 [10935643] Drug Metab Dispos. 2000 Sep;28(9):1051-7 [10950848] Antimicrob Agents Chemother. 2001 Feb;45(2):502-8 [11158747] Biochem Biophys Res Commun. 2001 Mar16;281(5):1349-55 [11243885] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74 [11248085] Pharmacogenetics. 2001 Mar;11(2):111-21 [11266076] Acta Pharmacol Sin. 2001 Oct;22(10):944-8 [11749780] Protein Expr Purif. 2002 Apr;24(3):329-37 [11922748] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8 [12509506] J Mass Spectrom. 2003 Feb;38(2):157-66 [12577282] Biochem Pharmacol. 1995 Nov 27;50(11):1841-50 [8615863] J Clin Invest. 1998 Sep 1;102(5):1016-23 [9727070] Annu Rev Pharmacol Toxicol. 1999;39:1-17 [10331074] J Biol Chem. 1999 Aug 20;274(34):23963-8 [10446164] Drug Metab Dispos. 2003 May;31(5):548-58 [12695342] Mol Pharmacol. 2003 Jul;64(1):42-50 [12815159] Drug Metab Dispos. 2003 Aug;31(8):1054-64 [12867495] Clin Pharmacokinet. 2003;42(9):819-50 [12882588] Hepatology. 2003 Oct;38(4):978-88 [14512885] J Biol Chem. 2003 Nov 14;278(46):45062-71 [12923173] Drug Metab Dispos. 2004 Feb;32(2):163-7 [14744936] Pharmacogenomics. 2004 Apr;5(3):243-72 [15102541] J Biol Chem. 1987 Oct 5;262(28):13534-7 [3654629] Clin Pharmacol Ther. 1990 Oct;48(4):365-74 [2121408] Biochemistry. 1990 Dec 25;29(51):11280-92 [2271712] Endocrinology. 2005 Jul;146(7):2911-9 [15817670] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/dmd.108.022723 ER - TY - JOUR T1 - Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. AN - 69801324; 18712364 AB - Serotonin transporter (SERT) knockout (-/-) mice have an altered phenotype in adulthood, including high baseline anxiety and depressive-like behaviors, associated with increased baseline extracellular serotonin levels throughout life. To examine the effects of increases in serotonin following the administration of the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) in SERT wild-type (+/+), heterozygous (+/-), and -/- mice. 5-HTP increased serotonin in all five brain areas examined with approximately 2- to 5-fold increases in SERT+/+ and +/- mice, and with greater 4.5- to 11.7-fold increases in SERT-/- mice. Behaviorally, 5-HTP induced exaggerated serotonin syndrome behaviors in SERT-/-, mice with similar effects in male and female mice. Studies suggest promiscuous serotonin uptake by the dopamine transporter (DAT) in SERT-/- mice, and here, the DAT blocker GBR 12909 enhanced 5-HTP-induced behaviors in SERT-/- mice. Physiologically, 5-HTP induced exaggerated temperature effects in SERT-deficient mice. The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only. WAY 100635 and SB 269970 together completely blocked 5-HTP-induced hypothermia in SERT+/- and -/- mice. These studies demonstrate that SERT-/- mice have exaggerated neurochemical, behavioral, and physiological responses to further increases in serotonin, and provide the first evidence of intact 5-HT7 receptor function in SERT-/- mice, with interesting interactions between 5-HT1A and 5-HT7 receptors. As roles for 5-HT7 receptors in anxiety and depression were recently established, the current findings have implications for understanding the high anxiety and depressive-like phenotype of SERT-deficient mice. JF - Psychopharmacology AU - Fox, Meredith A AU - Jensen, Catherine L AU - French, Helen T AU - Stein, Alison R AU - Huang, Su-Jan AU - Tolliver, Teresa J AU - Murphy, Dennis L AD - Laboratory of Clinical Science (LCS), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), 10 Center Drive, Building 10-3D41, MSC 1264, Bethesda, MD 20892-1264, USA. mfox@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 203 EP - 218 VL - 201 IS - 2 SN - 0033-3158, 0033-3158 KW - Catecholamines KW - 0 KW - Dopamine Uptake Inhibitors KW - Monoamine Oxidase Inhibitors KW - Phenols KW - Piperazines KW - Pyridines KW - SB 269970 KW - Serotonin 5-HT1 Receptor Antagonists KW - Serotonin Plasma Membrane Transport Proteins KW - Serotonin Receptor Agonists KW - Sulfonamides KW - Serotonin KW - 333DO1RDJY KW - Tranylcypromine KW - 3E3V44J4Z9 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide KW - 71IH826FEG KW - 8-Hydroxy-2-(di-n-propylamino)tetralin KW - 78950-78-4 KW - vanoxerine KW - 90X28IKH43 KW - 5-carboxamidotryptamine KW - 91H76044O0 KW - 5-Hydroxytryptophan KW - C1LJO185Q9 KW - Clorgyline KW - LYJ16FZU9Q KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Animals KW - Hydroxyindoleacetic Acid -- analysis KW - Brain -- drug effects KW - Catecholamines -- classification KW - Brain -- metabolism KW - Catecholamines -- antagonists & inhibitors KW - Piperazines -- pharmacology KW - Monoamine Oxidase Inhibitors -- pharmacology KW - Mice, Knockout KW - Tranylcypromine -- pharmacology KW - Sulfonamides -- pharmacology KW - Brain -- anatomy & histology KW - Hypothermia -- chemically induced KW - Clorgyline -- pharmacology KW - Serotonin Syndrome -- chemically induced KW - Drug Synergism KW - Male KW - Dopamine Uptake Inhibitors -- pharmacology KW - Phenols -- pharmacology KW - Hydroxyindoleacetic Acid -- metabolism KW - Mice KW - Piperazines -- toxicity KW - Drug Therapy, Combination KW - 8-Hydroxy-2-(di-n-propylamino)tetralin -- pharmacology KW - 5-Hydroxytryptophan -- pharmacology KW - Pyridines -- pharmacology KW - Female KW - Serotonin -- pharmacology KW - Serotonin Plasma Membrane Transport Proteins -- deficiency KW - Brain Chemistry -- drug effects KW - Serotonin -- analogs & derivatives KW - Serotonin -- metabolism KW - Serotonin Plasma Membrane Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69801324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Neurochemical%2C+behavioral%2C+and+physiological+effects+of+pharmacologically+enhanced+serotonin+levels+in+serotonin+transporter+%28SERT%29-deficient+mice.&rft.au=Fox%2C+Meredith+A%3BJensen%2C+Catherine+L%3BFrench%2C+Helen+T%3BStein%2C+Alison+R%3BHuang%2C+Su-Jan%3BTolliver%2C+Teresa+J%3BMurphy%2C+Dennis+L&rft.aulast=Fox&rft.aufirst=Meredith&rft.date=2008-12-01&rft.volume=201&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-008-1268-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Pharmacol. 1998 Apr;53(4):649-55 [9547354] J Clin Psychiatry. 1998;59 Suppl 15:4-12 [9786305] Depress Anxiety. 1998;8 Suppl 1:5-12 [9809208] J Neurosci Methods. 2004 Dec 30;140(1-2):169-81 [15589347] Neuropharmacology. 2005 Mar;48(4):492-502 [15755477] Psychopharmacology (Berl). 2005 Jun;180(1):12-20 [15834538] Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):1074-84 [15939518] Neuropharmacology. 2005 Nov;49(6):798-810 [16183083] Biol Psychiatry. 2005 Nov 15;58(10):831-7 [16018977] Eur J Pharmacol. 2006 Feb 27;532(3):258-64 [16488409] Gene Expr. 2006;13(1):53-7 [16572590] Trends Cogn Sci. 2006 Apr;10(4):182-91 [16530463] Am J Hum Genet. 2006 May;78(5):815-26 [16642437] Neuroscience. 2006 Jun 19;140(1):321-34 [16542782] Neurosci Lett. 2006 Jun 19;401(1-2):49-54 [16638624] J Neurosci. 2006 May 17;26(20):5554-64 [16707806] J Neurosci. 2000 Nov 1;20(21):7888-95 [11050108] Brain Res Dev Brain Res. 2001 Jan 31;126(1):125-9 [11172895] J Pharmacol Exp Ther. 2001 Mar;296(3):987-95 [11181933] Eur J Neurosci. 2001 Apr;13(7):1349-62 [11298795] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5300-5 [11320258] J Neurosci. 2001 Sep 1;21(17):6862-73 [11517274] Pharmacol Biochem Behav. 2002 Apr;71(4):555-68 [11888547] Brain Res. 2002 Jun 28;942(1-2):109-19 [12031859] J Pharmacol Exp Ther. 2002 Jul;302(1):240-8 [12065723] Endocrinology. 2002 Dec;143(12):4520-6 [12446578] Neuropsychopharmacology. 2002 Dec;27(6):914-23 [12464448] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1375-80 [12529502] J Neurosci Res. 2003 Mar 1;71(5):701-9 [12584728] Neurosci Lett. 2006 Aug 14;404(1-2):122-6 [16759802] Neuropharmacology. 2006 Sep;51(3):578-86 [16828124] Eur J Pharmacol. 2006 Dec 28;553(1-3):185-90 [17097082] Eur J Pharmacol. 2007 Jan 19;555(1):43-7 [17109856] J Neurosci. 2007 Jan 17;27(3):684-91 [17234600] J Pharmacol Exp Ther. 2007 May;321(2):690-8 [17314195] J Pharmacol Exp Ther. 2007 Jun;321(3):1054-61 [17337633] Genes Brain Behav. 2007 Jun;6(4):389-400 [16939636] Biol Psychiatry. 2007 Aug 15;62(4):327-31 [17210141] Neuropharmacology. 2007 Oct;53(5):643-56 [17765930] Psychopharmacology (Berl). 2007 Dec;195(2):147-66 [17712549] Trends Pharmacol Sci. 2007 Dec;28(12):629-36 [17996955] J Neurosci. 2008 Jan 2;28(1):199-207 [18171937] Mol Psychiatry. 2008 Feb;13(2):131-46 [17700575] Nat Rev Neurosci. 2008 Feb;9(2):85-96 [18209729] J Neurosci. 2008 Apr 2;28(14):3546-54 [18385313] J Neurosci. 2003 Oct 1;23(26):8836-43 [14523084] Eur J Neurosci. 2003 Oct;18(8):2203-12 [14622181] Neuropsychopharmacology. 2003 Dec;28(12):2077-88 [12968128] Genes Brain Behav. 2003 Dec;2(6):365-80 [14653308] Eur J Pharmacol. 2004 Mar 8;487(1-3):125-32 [15033384] Mol Interv. 2004 Apr;4(2):109-23 [15087484] Brain Res Dev Brain Res. 2004 Jun 21;150(2):151-61 [15158078] Neuropsychopharmacology. 2004 Oct;29(10):1790-9 [15226739] Science. 2004 Oct 29;306(5697):879-81 [15514160] Life Sci. 1976 Sep 15;19(6):777-85 [823389] J Pharmacol Exp Ther. 1984 Jan;228(1):133-9 [6694097] Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):783-6 [6141618] Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):653-6 [6531436] Eur J Pharmacol. 1985 Dec 17;119(3):143-52 [4092729] Neuropharmacology. 1985 Dec;24(12):1187-94 [2869435] Pharmacol Biochem Behav. 1986 Jun;24(6):1513-9 [2942947] Psychopharmacology (Berl). 1986;90(4):488-93 [2949333] Psychopharmacology (Berl). 1987;91(4):500-5 [2954178] Psychopharmacology (Berl). 1987;91(4):506-11 [2954179] Eur J Pharmacol. 1988 Sep 23;154(3):299-304 [2976671] Br J Pharmacol. 1991 Aug;103(4):1857-64 [1833017] Nature. 1991 Nov 7;354(6348):66-70 [1944572] Br J Pharmacol. 1992 Sep;107(1):15-21 [1422568] J Neurochem. 1993 Mar;60(3):1167-70 [8094744] Pharmacol Rev. 1994 Jun;46(2):157-203 [7938165] J Pharmacol Exp Ther. 1999 Dec;291(3):999-1007 [10565817] Br J Pharmacol. 2000 Jun;130(3):539-48 [10821781] Eur J Neurosci. 2000 Jul;12(7):2299-310 [10947809] Neuroreport. 2003 Feb 10;14(2):233-8 [12598736] Neuropharmacology. 2003 Jun;44(8):1031-7 [12763096] J Neurochem. 2003 Jul;86(1):210-9 [12807440] Science. 2003 Jul 18;301(5631):386-9 [12869766] Science. 1996 Nov 29;274(5292):1527-31 [8929413] Neurosci Lett. 1997 May 9;227(1):53-6 [9178857] J Pharmacol Exp Ther. 1997 Aug;282(2):699-706 [9262333] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00213-008-1268-7 ER - TY - JOUR T1 - Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. AN - 69796090; 18809576 AB - Nuclear factor of activated T cells (NFAT) was first described as an activation and differentiation transcription factor in lymphocytes. Several in vitro studies suggest that NFAT family members are redundant proteins. However, analysis of mice deficient for NFAT proteins suggested different roles for the NFAT family of transcription factors in the regulation of cell proliferation and apoptosis. NFAT may also regulate several cell cycle and survival factors influencing tumor growth and survival. Here, we demonstrate that two constitutively active forms of NFAT proteins (CA-NFAT1 and CA-NFAT2 short isoform) induce distinct phenotypes in NIH 3T3 cells. Whereas CA-NFAT1 expression induces cell cycle arrest and apoptosis in NIH 3T3 fibroblasts, CA-NFAT2 short isoform leads to increased proliferation capacity and induction of cell transformation. Furthermore, NFAT1-deficient mice showed an increased propensity for chemical carcinogen-induced tumor formation, and CA-NFAT1 expression subverted the transformation of NIH 3T3 cells induced by the H-rasV12 oncogene. The differential roles for NFAT1 are at least partially due to the protein C-terminal domain. These results suggest that the NFAT1 gene acts as a tumor suppressor gene and the NFAT2 short isoform acts gene as an oncogene, supporting different roles for the two transcription factors in tumor development. JF - Molecular and cellular biology AU - Robbs, Bruno K AU - Cruz, Andre L S AU - Werneck, Miriam B F AU - Mognol, Giuliana P AU - Viola, João P B AD - Division of Cellular Biology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 7168 EP - 7181 VL - 28 IS - 23 KW - NFATC Transcription Factors KW - 0 KW - Nfatc1 protein, mouse KW - Nfatc2 protein, mouse KW - Protein Isoforms KW - Index Medicus KW - Phenotype KW - Animals KW - 3T3 Cells KW - Apoptosis KW - Mice KW - Mice, Inbred BALB C KW - Cell Proliferation KW - Cell Cycle KW - Cell Transformation, Neoplastic -- genetics KW - Mice, Knockout KW - Oncogenes KW - NFATC Transcription Factors -- genetics KW - Genes, Tumor Suppressor KW - NFATC Transcription Factors -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69796090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Dual+roles+for+NFAT+transcription+factor+genes+as+oncogenes+and+tumor+suppressors.&rft.au=Robbs%2C+Bruno+K%3BCruz%2C+Andre+L+S%3BWerneck%2C+Miriam+B+F%3BMognol%2C+Giuliana+P%3BViola%2C+Jo%C3%A3o+P+B&rft.aulast=Robbs&rft.aufirst=Bruno&rft.date=2008-12-01&rft.volume=28&rft.issue=23&rft.spage=7168&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.00256-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1998 Mar 12;392(6672):186-90 [9515964] Nature. 1998 Mar 12;392(6672):182-6 [9515963] Immunity. 1998 Nov;9(5):627-35 [9846484] Immunity. 1999 Feb;10(2):261-9 [10072078] J Immunol. 1999 Jun 15;162(12):7294-301 [10358178] Blood. 2004 Nov 15;104(10):3358-60 [15297316] Nature. 2004 Nov 18;432(7015):307-15 [15549092] Br J Haematol. 2005 Feb;128(3):333-42 [15667535] J Biol Chem. 2005 Mar 11;280(10):8686-93 [15632146] Braz J Med Biol Res. 2005 Mar;38(3):335-44 [15761612] Nat Rev Immunol. 2005 Jun;5(6):472-84 [15928679] Blood. 2005 Nov 15;106(10):3546-52 [16051745] Blood. 2005 Dec 1;106(12):3940-7 [16099873] Blood. 2006 Jun 1;107(11):4540-8 [16497967] EMBO J. 2006 Aug 9;25(15):3714-24 [16874304] Oncogene. 2006 Sep 14;25(41):5640-7 [16619034] Nature. 2006 Sep 21;443(7109):345-9 [16988714] Nat Med. 2007 Jun;13(6):736-41 [17515895] Cell Cycle. 2007 Jul 15;6(14):1789-95 [17637565] Am J Pathol. 2008 Jan;172(1):215-24 [18156209] J Exp Med. 2000 Jan 3;191(1):9-22 [10620601] Cell. 2000 Jan 7;100(1):57-70 [10647931] Mol Cell Biol. 2000 Jun;20(12):4309-19 [10825194] J Biol Chem. 2000 Aug 4;275(31):23627-35 [10816557] Mol Cell. 2000 Sep;6(3):539-50 [11030334] Biochem Biophys Res Commun. 2000 Sep 24;276(2):466-71 [11027498] J Biol Chem. 2001 Apr 27;276(17):14350-8 [11278367] Mol Cells. 2002 Feb 28;13(1):77-84 [11911478] Immunity. 2002 Jun;16(6):881-95 [12121669] Eur J Immunol. 2002 Oct;32(10):2971-8 [12355451] Mol Cell. 2002 Nov;10(5):1071-81 [12453415] FASEB J. 2002 Dec;16(14):1940-2 [12368232] Blood. 2003 Feb 15;101(4):1505-12 [12393731] J Biol Chem. 2003 May 9;278(19):17246-54 [12598522] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D523-7 [14681473] Cell. 1991 Jan 25;64(2):313-26 [1988150] Nature. 1992 Jun 25;357(6380):695-7 [1377362] Immunity. 1996 Apr;4(4):397-405 [8612134] Science. 1996 May 10;272(5263):892-5 [8629027] Nature. 1996 Jul 25;382(6589):370-3 [8684469] J Exp Med. 1996 Jul 1;184(1):141-7 [8691127] Annu Rev Immunol. 1997;15:707-47 [9143705] J Biol Chem. 1997 Dec 12;272(50):31427-34 [9395475] Immunity. 1998 Jan;8(1):115-24 [9462517] Eur J Immunol. 1998 Aug;28(8):2456-66 [9710223] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.00256-08 ER - TY - JOUR T1 - Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. AN - 69791961; 18977148 AB - Compounds that stabilize p53 could suppress tumors providing a additional tool to fight cancer. Mdm2, and the human ortholog, Hdm2 serve as ubiquitin E3 ligases and target p53 for ubiquitylation and degradation. Inhibition of Hdm2 stabilizes p53, inhibits cell proliferation and induces apoptosis. Using HTS to discover inhibitors, we identified three new alkaloids, isolissoclinotoxin B, diplamine B, and lissoclinidine B from Lissoclinum cf. badium. Lissoclinidine B inhibited ubiquitylation and degradation of p53, and selectively killed transformed cells harboring wild-type p53, suggesting this compound could be used to develop new treatments. JF - Bioorganic & medicinal chemistry AU - Clement, Jason A AU - Kitagaki, Jirouta AU - Yang, Yili AU - Saucedo, Carrie J AU - O'Keefe, Barry R AU - Weissman, Allan M AU - McKee, Tawnya C AU - McMahon, James B AD - Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 10022 EP - 10028 VL - 16 IS - 23 KW - Acridines KW - 0 KW - Alkaloids KW - Enzyme Inhibitors KW - Phenanthrolines KW - Tumor Suppressor Protein p53 KW - Ubiquitin KW - pyridoacridine KW - MDM2 protein, human KW - EC 2.3.2.27 KW - Proto-Oncogene Proteins c-mdm2 KW - Index Medicus KW - Animals KW - Ubiquitin -- metabolism KW - Phenanthrolines -- chemistry KW - Humans KW - Acridines -- isolation & purification KW - Phenanthrolines -- metabolism KW - Phenanthrolines -- isolation & purification KW - Inhibitory Concentration 50 KW - Cell Line, Transformed KW - Acridines -- metabolism KW - Acridines -- chemistry KW - Alkaloids -- chemistry KW - Enzyme Inhibitors -- chemistry KW - Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - Alkaloids -- pharmacology KW - Alkaloids -- isolation & purification KW - Proto-Oncogene Proteins c-mdm2 -- metabolism KW - Enzyme Inhibitors -- isolation & purification KW - Urochordata -- chemistry KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69791961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Discovery+of+new+pyridoacridine+alkaloids+from+Lissoclinum+cf.+badium+that+inhibit+the+ubiquitin+ligase+activity+of+Hdm2+and+stabilize+p53.&rft.au=Clement%2C+Jason+A%3BKitagaki%2C+Jirouta%3BYang%2C+Yili%3BSaucedo%2C+Carrie+J%3BO%27Keefe%2C+Barry+R%3BWeissman%2C+Allan+M%3BMcKee%2C+Tawnya+C%3BMcMahon%2C+James+B&rft.aulast=Clement&rft.aufirst=Jason&rft.date=2008-12-01&rft.volume=16&rft.issue=23&rft.spage=10022&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=1464-3391&rft_id=info:doi/10.1016%2Fj.bmc.2008.10.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-09 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Mar 24;275(12):8945-51 [10722742] J Biomol Screen. 2008 Mar;13(3):229-37 [18270365] J Am Chem Soc. 2001 Jan 31;123(4):554-60 [11456567] J Nat Prod. 2001 Sep;64(9):1169-73 [11575950] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3529-34 [11891335] Cancer Lett. 2002 Sep 8;183(1):69-77 [12049816] Nat Rev Cancer. 2003 Feb;3(2):102-9 [12563309] J Nat Prod. 2003 Feb;66(2):247-50 [12608858] J Nat Prod. 2003 Jul;66(7):1022-37 [12880330] Science. 2004 Feb 6;303(5659):844-8 [14704432] Oncogene. 2004 Mar 15;23(11):2096-106 [15021897] Cell Mol Life Sci. 2004 Jul;61(13):1546-61 [15224180] J Med Chem. 1989 Jun;32(6):1354-9 [2724306] Science. 1991 Jun 21;252(5013):1708-11 [2047879] Cell. 1993 Sep 24;74(6):957-67 [8402885] J Nat Prod. 1994 Oct;57(10):1336-45 [7807120] J Nat Prod. 1995 Feb;58(2):254-8 [7769392] Nature. 1995 Nov 9;378(6553):203-6 [7477326] Nature. 1995 Nov 9;378(6553):206-8 [7477327] Mol Med. 1995 Jan;1(2):142-52 [8529093] Nature. 1997 May 15;387(6630):296-9 [9153395] Nature. 1997 May 15;387(6630):299-303 [9153396] FEBS Lett. 1997 Dec 22;420(1):25-7 [9450543] Nucleic Acids Res. 1998 Aug 1;26(15):3453-9 [9671804] Mol Med. 1999 Jan;5(1):21-34 [10072445] Nat Med. 2004 Dec;10(12):1321-8 [15558054] J Biomol Screen. 2004 Dec;9(8):695-703 [15634796] Curr Cancer Drug Targets. 2005 Feb;5(1):43-9 [15720188] World J Gastroenterol. 2005 May 21;11(19):2927-31 [15902730] Cancer Cell. 2005 Jun;7(6):547-59 [15950904] Genes Dev. 2006 Jan 15;20(2):125-31 [16418478] Cell Death Differ. 2006 Jun;13(6):1027-36 [16557269] J Med Chem. 2006 Jun 15;49(12):3432-5 [16759082] Nat Rev Mol Cell Biol. 2007 Apr;8(4):275-83 [17380161] Cell. 2007 Aug 24;130(4):597-600 [17719538] Biochemistry. 2001 Jan 16;40(2):336-44 [11148027] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmc.2008.10.024 ER - TY - JOUR T1 - Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide. AN - 69778523; 18812491 AB - A variety of peptide ligands are known to inhibit the function of neuronal nicotinic acetylcholine receptors (nAChRs), including small toxins and brain-derived peptides such as beta-amyloid(1-42) and synthetic apolipoproteinE peptides. The myristoylated alanine-rich C kinase substrate (MARCKS) protein is a major substrate of protein kinase C and is highly expressed in the developing and adult brain. The ability of a 25-amino acid synthetic MARCKS peptide, derived from the effector domain (ED), to modulate nAChR activity was tested. To determine the effects of the MARCKS ED peptide on nAChR function, receptors were expressed in Xenopus laevis oocytes, and two-electrode voltage-clamp experiments were performed. The MARCKS ED peptide completely inhibited acetylcholine (ACh)-evoked responses from alpha7 nAChRs in a dose-dependent manner, yielding an IC(50) value of 16 nM. Inhibition of ACh-induced responses was both activity- and voltage-independent. The MARCKS ED peptide was unable to block alpha-bungarotoxin binding. A MARCKS ED peptide in which four serine residues were replaced with aspartate residues was unable to inhibit alpha7 nAChR-mediated currents. The MARCKS ED peptide inhibited ACh-induced alpha4beta2 and alpha2beta2 responses, although with decreased potency. The effects of the MARCKS ED peptide on native nAChRs were tested using acutely isolated rat hippocampal slices. In hippocampal interneurons, the MARCKS ED peptide was able to block native alpha7 nAChRs in a dose-dependent manner. The MARCKS ED peptide represents a novel antagonist of neuronal nAChRs that has considerable utility as a research tool. JF - The Journal of pharmacology and experimental therapeutics AU - Gay, Elaine A AU - Klein, Rebecca C AU - Melton, Mark A AU - Blackshear, Perry J AU - Yakel, Jerrel L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 884 EP - 890 VL - 327 IS - 3 KW - Chrna7 protein, human KW - 0 KW - Chrna7 protein, rat KW - Intracellular Signaling Peptides and Proteins KW - Membrane Proteins KW - Nicotinic Antagonists KW - Receptors, Nicotinic KW - Recombinant Proteins KW - alpha7 Nicotinic Acetylcholine Receptor KW - myristoylated alanine-rich C kinase substrate KW - 125267-21-2 KW - Index Medicus KW - Rats KW - Xenopus laevis KW - Animals KW - Dose-Response Relationship, Drug KW - Oocytes KW - Inhibitory Concentration 50 KW - Electrophysiology KW - Mutation, Missense KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Receptors, Nicotinic -- drug effects KW - Membrane Proteins -- genetics KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Membrane Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69778523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+native+and+recombinant+nicotinic+acetylcholine+receptors+by+the+myristoylated+alanine-rich+C+kinase+substrate+peptide.&rft.au=Gay%2C+Elaine+A%3BKlein%2C+Rebecca+C%3BMelton%2C+Mark+A%3BBlackshear%2C+Perry+J%3BYakel%2C+Jerrel+L&rft.aulast=Gay&rft.aufirst=Elaine&rft.date=2008-12-01&rft.volume=327&rft.issue=3&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.144758 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-05 N1 - Date created - 2008-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2006 Sep;318(3):956-65 [16740622] Hippocampus. 2006;16(5):495-503 [16572394] J Pharmacol Exp Ther. 2001 Aug;298(2):395-402 [11454899] Mol Pharmacol. 2002 Jan;61(1):43-54 [11752205] Biochem J. 2002 Feb 15;362(Pt 1):1-12 [11829734] J Physiol. 2000 Sep 15;527 Pt 3:515-28 [10990538] J Neurosci. 2001 Jan 1;21(1):RC120 [11150356] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4734-9 [11274373] Eur J Neurosci. 2001 May;13(10):1849-60 [11403678] J Biol Chem. 2002 Jul 12;277(28):25056-61 [11983690] J Physiol. 2003 Feb 15;547(Pt 1):147-57 [12562926] Nat Struct Biol. 2003 Mar;10(3):226-31 [12577052] Br J Pharmacol. 2003 Jul;139(6):1061-73 [12871824] J Neurosci. 2003 Jul 30;23(17):6740-7 [12890766] J Neurosci. 2003 Oct 8;23(27):9024-31 [14534236] Biochem Cell Biol. 2004 Feb;82(1):191-200 [15052337] J Neurochem. 2004 Jul;90(2):325-31 [15228589] Neuroscience. 2004;127(3):563-7 [15283956] J Biol Chem. 2004 Sep 3;279(36):37842-51 [15234980] J Physiol. 1988 Jan;395:131-59 [2457675] J Biol Chem. 1989 Dec 25;264(36):21818-23 [2557340] J Neurosci. 1990 May;10(5):1683-98 [2332803] J Biol Chem. 1991 Aug 5;266(22):14390-8 [1650359] Cell. 1992 Nov 27;71(5):713-6 [1423627] J Physiol. 1992 Aug;454:155-82 [1282155] J Biol Chem. 1993 Jan 25;268(3):1501-4 [8420923] Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):944-8 [7862670] J Biol Chem. 1996 Jan 5;271(1):553-62 [8550618] J Biol Chem. 1997 Sep 19;272(38):23833-42 [9295331] Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14517-22 [9826732] Exp Neurol. 2005 Mar;192(1):109-16 [15698624] Neurosci Lett. 2005 Jun 24;381(3):305-8 [15896489] Hippocampus. 2005;15(5):675-83 [15889447] J Mol Neurosci. 2005;27(1):13-21 [16055943] Neuron. 2005 Oct 6;48(1):77-90 [16202710] J Pharmacol Exp Ther. 2006 Feb;316(2):835-42 [16249370] Biochem Pharmacol. 2007 Oct 15;74(8):1092-101 [17662959] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.144758 ER - TY - JOUR T1 - Acute 5-HT reuptake blockade potentiates human amygdala reactivity. AN - 69773069; 18463627 AB - Variability in serotonin (5-HT) function is associated with individual differences in normal mood and temperament, as well as psychiatric illnesses, all of which are influenced by amygdala function. This study evaluated the acute effects of 5-HT reuptake blockade on amygdala function using pharmacological functional MRI. Eight healthy men completed a double-blind balanced crossover study with the selective 5-HT reuptake inhibitor, citalopram (20 mg infused over 30 min), and normal saline. Amygdala reactivity in response to novel facial expressions was assessed on three successive scans, once before drug/placebo infusion, once early in the infusion, and once at the end of infusion. Acute citalopram administration resulted in concentration-dependent increases in human amygdala reactivity to salient stimuli. The current pattern of 5-HT-mediated amygdala reactivity may represent an important pathway through which SSRIs achieve an antidepressant effect. Intriguingly, our data may also reveal a mechanism contributing to clinical observations of extreme agitation, restlessness, and suicidal ideation in some individuals during acute SSRI treatment. Developing a comprehensive model of how 5-HT modulates human amygdala reactivity supporting behavioral and physiological arousal will be instrumental for our understanding of basic neurobehavioral processes, their dysfunction in psychiatric illnesses, and their contribution to mechanism of treatment response. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Bigos, Kristin L AU - Pollock, Bruce G AU - Aizenstein, Howard J AU - Fisher, Patrick M AU - Bies, Robert R AU - Hariri, Ahmad R AD - Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA. bigosk@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3221 EP - 3225 VL - 33 IS - 13 KW - Serotonin Uptake Inhibitors KW - 0 KW - Citalopram KW - 0DHU5B8D6V KW - Serotonin KW - 333DO1RDJY KW - Index Medicus KW - Young Adult KW - Akathisia, Drug-Induced -- metabolism KW - Anxiety -- metabolism KW - Double-Blind Method KW - Anxiety -- chemically induced KW - Dose-Response Relationship, Drug KW - Humans KW - Anxiety -- physiopathology KW - Akathisia, Drug-Induced -- physiopathology KW - Presynaptic Terminals -- metabolism KW - Facial Expression KW - Presynaptic Terminals -- drug effects KW - Photic Stimulation KW - Adult KW - Cross-Over Studies KW - Depressive Disorder -- physiopathology KW - Depressive Disorder -- drug therapy KW - Middle Aged KW - Serotonin Uptake Inhibitors -- pharmacology KW - Neuropsychological Tests KW - Depressive Disorder -- metabolism KW - Male KW - Amygdala -- metabolism KW - Brain Chemistry -- drug effects KW - Citalopram -- pharmacology KW - Amygdala -- drug effects KW - Serotonin -- metabolism KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69773069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Acute+5-HT+reuptake+blockade+potentiates+human+amygdala+reactivity.&rft.au=Bigos%2C+Kristin+L%3BPollock%2C+Bruce+G%3BAizenstein%2C+Howard+J%3BFisher%2C+Patrick+M%3BBies%2C+Robert+R%3BHariri%2C+Ahmad+R&rft.aulast=Bigos&rft.aufirst=Kristin&rft.date=2008-12-01&rft.volume=33&rft.issue=13&rft.spage=3221&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.52 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chem Neuroanat. 2001 Sep;22(3):185-203 [11522440] Trends Pharmacol Sci. 2007 Dec;28(12):629-36 [17996955] Neuroimage. 2003 Jul;19(3):1233-9 [12880848] Neuroimage. 2004 Jan;21(1):450-5 [14741682] Biol Psychiatry. 2004 Jun 15;55(12):1171-8 [15184036] J Cogn Neurosci. 2004 Jun;16(5):786-93 [15200706] Magn Reson Med. 1995 May;33(5):636-47 [7596267] Psychopharmacol Bull. 1997;33(1):109-12 [9133760] Neuropsychopharmacology. 1999 Aug;21(2 Suppl):91S-98S [10432494] Nat Neurosci. 2005 Jan;8(1):20-1 [15592465] Mol Psychiatry. 2005 Sep;10(9):884-8, 805 [16044172] Trends Cogn Sci. 2006 Apr;10(4):182-91 [16530463] Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6269-74 [16569698] Biol Psychiatry. 2006 May 1;59(9):816-20 [16460693] Neuroscience. 2006 Aug 25;141(2):1047-55 [16713119] Nat Neurosci. 2006 Nov;9(11):1362-3 [17013380] JAMA. 2007 Apr 18;297(15):1683-96 [17440145] Neuroscience. 2007 Apr 25;146(1):306-20 [17331657] J Neurosci. 2007 Aug 22;27(34):9233-7 [17715358] Biol Psychiatry. 2007 Nov 15;62(10):1111-8 [17524369] Science. 2002 Jul 19;297(5580):400-3 [12130784] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.52 ER - TY - JOUR T1 - Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. AN - 69770199; 18710431 AB - The sequences encoding the QUAD1 RNAs were initially identified as four repeats in Escherichia coli. These repeats, herein renamed SIB, are conserved in closely related bacteria, although the number of repeats varies. All five Sib RNAs in E. coli MG1655 are expressed, and no phenotype was observed for a five-sib deletion strain. However, a phenotype reminiscent of plasmid addiction was observed for overexpression of the Sib RNAs, and further examination of the SIB repeat sequences revealed conserved open reading frames encoding highly hydrophobic 18- to 19-amino-acid proteins (Ibs) opposite each sib gene. The Ibs proteins were found to be toxic when overexpressed and this toxicity could be prevented by coexpression of the corresponding Sib RNA. Two other RNAs encoded divergently in the yfhL-acpS intergenic region were similarly found to encode a small hydrophobic protein (ShoB) and an antisense RNA regulator (OhsC). Overexpression of both IbsC and ShoB led to immediate changes in membrane potential suggesting both proteins affect the cell envelope. Whole genome expression analysis showed that overexpression of IbsC and ShoB, as well as the small hydrophobic LdrD and TisB proteins, has both overlapping and unique consequences for the cell. JF - Molecular microbiology AU - Fozo, Elizabeth M AU - Kawano, Mitsuoki AU - Fontaine, Fanette AU - Kaya, Yusuf AU - Mendieta, Kathy S AU - Jones, Kristi L AU - Ocampo, Alejandro AU - Rudd, Kenneth E AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1076 EP - 1093 VL - 70 IS - 5 KW - RNA, Bacterial KW - 0 KW - Index Medicus KW - Gene Expression Regulation, Bacterial KW - Transformation, Bacterial KW - Genes, Bacterial KW - Base Sequence KW - Sequence Alignment KW - Oligonucleotide Array Sequence Analysis KW - Genome, Bacterial KW - Open Reading Frames KW - Molecular Sequence Data KW - Membrane Potentials KW - Repetitive Sequences, Nucleic Acid KW - Gene Deletion KW - Protein Biosynthesis KW - Escherichia coli -- metabolism KW - Escherichia coli -- genetics KW - RNA, Bacterial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69770199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Repression+of+small+toxic+protein+synthesis+by+the+Sib+and+OhsC+small+RNAs.&rft.au=Fozo%2C+Elizabeth+M%3BKawano%2C+Mitsuoki%3BFontaine%2C+Fanette%3BKaya%2C+Yusuf%3BMendieta%2C+Kathy+S%3BJones%2C+Kristi+L%3BOcampo%2C+Alejandro%3BRudd%2C+Kenneth+E%3BStorz%2C+Gisela&rft.aulast=Fozo&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=70&rft.issue=5&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=1365-2958&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06394.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-26 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 1995 Jul;177(14):4121-30 [7608087] Gene. 1995 May 26;158(1):9-14 [7789817] Curr Biol. 2004 Dec 29;14(24):2271-6 [15620655] Nucleic Acids Res. 2005;33(3):1040-50 [15718303] Nat Rev Microbiol. 2005 May;3(5):371-82 [15864262] Mol Microbiol. 2005 Aug;57(3):621-8 [16045608] J Bacteriol. 2005 Oct;187(20):6962-71 [16199566] Mol Microbiol. 2006 Jan;59(1):231-47 [16359331] PLoS Biol. 2006 Jan;4(1):e2 [16336047] Mol Syst Biol. 2006;2:2006.0007 [16738553] Curr Opin Microbiol. 2007 Apr;10(2):117-24 [17376733] Curr Opin Microbiol. 2007 Apr;10(2):96-101 [17383222] Mol Microbiol. 2007 May;64(3):738-54 [17462020] Mol Cell. 2007 May 11;26(3):381-92 [17499044] Curr Opin Microbiol. 2007 Jun;10(3):257-61 [17553733] Mol Microbiol. 2007 Oct;66(1):100-9 [17725563] Mol Microbiol. 1999 Jun;32(5):1090-102 [10361310] Res Microbiol. 1999 Nov-Dec;150(9-10):653-64 [10673004] Antimicrob Agents Chemother. 2000 Mar;44(3):682-7 [10681338] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5978-83 [10811905] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] Genes Dev. 2001 Jul 1;15(13):1637-51 [11445539] Curr Biol. 2001 Jun 26;11(12):941-50 [11448770] Curr Biol. 2001 Sep 4;11(17):1369-73 [11553332] Mol Microbiol. 2002 Jul;45(2):333-49 [12123448] Nucleic Acids Res. 2003 Apr 1;31(7):1813-20 [12654996] Science. 2003 Sep 12;301(5639):1496-9 [12970556] Gene. 2003 Oct 2;315:63-9 [14557065] J Bacteriol. 2004 Oct;186(20):6698-705 [15466020] EMBO J. 1986 Aug;5(8):2023-9 [3019679] Gene. 1987;53(1):85-96 [3596251] Gene. 1989 Apr 15;77(1):61-8 [2744488] J Mol Biol. 1991 Jul 5;220(1):35-48 [1712397] Erratum In: Mol Microbiol. 2008 Dec;70(5):1305 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x ER - TY - JOUR T1 - Trastuzumab cardiotoxicity: biological hypotheses and clinical open issues. AN - 69762284; 18990083 AB - Trastuzumab has significantly improved the prognosis of breast cancer patients overexpressing the human epidermal growth factor receptor 2 (HER2). This result has been achieved in all disease settings, by increasing overall survival in early stage and advanced disease and by increasing pathological complete responses in neoadjuvant disease. Although the greatest impact of this monoclonal antibody has been seen in the adjuvant setting, by increasing disease-free survival and overall survival rates an increased rate of both symptomatic and non-symptomatic cardiac toxicity has also been observed. In the following review, the different mechanisms of trastuzumab cardiac toxicity are described and, in addition, the clinical data coming from both trials and meta-analyses is discussed. While there is strong evidence for the incidence of trastuzumab-related cardiac toxicity, there is still little known on the exact pathogenesis of this toxicity. Interestingly, both experimental and clinical data suggest that trastuzumab may sensitize cardiomyocytes to injuries and stress from administration of anthracyclines. This has led to a proposed novel mechanism of cardiotoxicity that appears to be quite different from the anthracycline-associated cardiotoxicity. Trastuzumab does not seem to cause any overt ultrastructural abnormality; it does, however, lead to myocardial dysfunction. Most of the proposed hypotheses seems to be related to the activity of trastuzumab in interfering with the ERBB-2 receptor. Indeed, data from clinical trials in the adjuvant setting report increased cardiac toxicity in those patients who previously received anthracyclines. JF - Expert opinion on biological therapy AU - Bria, Emilio AU - Cuppone, Federica AU - Milella, Michele AU - Verma, Sunil AU - Carlini, Paolo AU - Nisticò, Cecilia AU - Vaccaro, Vanja AU - Rossi, Antonio AU - Tonini, Giuseppe AU - Cognetti, Francesco AU - Terzoli, Edmondo AD - Regina Elena National Cancer Institute, Department of Medical Oncology, Via Elio Chianesi 53, 00144, Rome, Italy. emiliobria@yahoo.it Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1963 EP - 1971 VL - 8 IS - 12 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Trastuzumab KW - P188ANX8CK KW - Index Medicus KW - Breast Neoplasms -- drug therapy KW - Survival Rate KW - Breast Neoplasms -- pathology KW - Humans KW - Prognosis KW - Clinical Trials as Topic KW - Heart -- drug effects KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69762284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=Trastuzumab+cardiotoxicity%3A+biological+hypotheses+and+clinical+open+issues.&rft.au=Bria%2C+Emilio%3BCuppone%2C+Federica%3BMilella%2C+Michele%3BVerma%2C+Sunil%3BCarlini%2C+Paolo%3BNistic%C3%B2%2C+Cecilia%3BVaccaro%2C+Vanja%3BRossi%2C+Antonio%3BTonini%2C+Giuseppe%3BCognetti%2C+Francesco%3BTerzoli%2C+Edmondo&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2008-12-01&rft.volume=8&rft.issue=12&rft.spage=1963&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/10.1517%2F14728220802517935 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/14728220802517935 ER - TY - JOUR T1 - Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists. AN - 69630864; 18767034 AB - Exposure to ionizing radiation has been consistently associated with increased risk of female breast cancer. Although the majority of DNA damage caused by ionizing radiation is corrected by the base-excision repair pathway, certain types of multiple-base damage can only be repaired through the nucleotide excision repair pathway. In a nested case-control study of breast cancer in US radiologic technologists exposed to low levels of ionizing radiation (858 cases, 1,083 controls), we examined whether risk of breast cancer conferred by radiation was modified by nucleotide excision gene polymorphisms ERCC2 (XPD) rs13181, ERCC4 (XPF) rs1800067 and rs1800124, ERCC5 (XPG) rs1047769 and rs17655; and ERCC6 rs2228526. Of the 6 ERCC variants examined, only ERCC5 rs17655 showed a borderline main effect association with breast cancer risk (OR(GC) = 1.1, OR(CC) = 1.3; p-trend = 0.08), with some indication that individuals carrying the C allele variant were more susceptible to the effects of occupational radiation (EOR/Gy(GG) = 1.0, 95% CI = <0, 6.0; EOR/Gy(GC/CC) = 5.9, 95% CI = 0.9, 14.4; p(het) = 0.10). ERCC2 rs13181, although not associated with breast cancer risk overall, statistically significantly modified the effect of occupational radiation dose on risk of breast cancer (EOR/Gy(AA) = 9.1, 95% CI = 2.1-21.3; EOR/Gy(AC/CC) = 0.6, 95% CI = <0, 4.6; p(het) = 0.01). These results suggest that common variants in nucleotide excision repair genes may modify the association between occupational radiation exposure and breast cancer risk. (c) 2008 Wiley-Liss, Inc. JF - International journal of cancer AU - Rajaraman, Preetha AU - Bhatti, Parveen AU - Doody, Michele Morin AU - Simon, Steven L AU - Weinstock, Robert M AU - Linet, Martha S AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Alexander, Bruce H AU - Preston, Dale L AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA. rajarama@mail.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 2713 EP - 2716 VL - 123 IS - 11 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Risk Factors KW - Humans KW - United States -- epidemiology KW - Male KW - Female KW - Radiation, Ionizing KW - DNA Repair -- genetics KW - Breast Neoplasms -- genetics KW - Occupational Exposure -- statistics & numerical data KW - Health Personnel -- statistics & numerical data KW - Genetic Predisposition to Disease -- genetics KW - Polymorphism, Genetic -- genetics KW - DNA -- metabolism KW - DNA -- genetics KW - Breast Neoplasms -- metabolism KW - Breast Neoplasms -- epidemiology KW - Technology, Radiologic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69630864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Nucleotide+excision+repair+polymorphisms+may+modify+ionizing+radiation-related+breast+cancer+risk+in+US+radiologic+technologists.&rft.au=Rajaraman%2C+Preetha%3BBhatti%2C+Parveen%3BDoody%2C+Michele+Morin%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BLinet%2C+Martha+S%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BAlexander%2C+Bruce+H%3BPreston%2C+Dale+L%3BSigurdson%2C+Alice+J&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2008-12-01&rft.volume=123&rft.issue=11&rft.spage=2713&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.23779 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-22 N1 - Date created - 2008-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3832-7 [10759556] Int J Cancer. 2003 Feb 20;103(5):671-5 [12494477] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] J Chronic Dis. 1987;40 Suppl 2:45S-57S [3312274] J Biol Chem. 1989 Mar 25;264(9):5172-6 [2538476] Biochemistry. 1989 Oct 3;28(20):7979-84 [2690930] Mutat Res. 1990 Mar;235(2):147-56 [2407949] Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2059-64 [15598761] Breast Cancer Res. 2005;7(1):21-32 [15642178] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Breast Cancer Res Treat. 2006 Jan;95(1):73-80 [16319991] Carcinogenesis. 2006 Jul;27(7):1377-85 [16399771] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1614-9 [16985021] Breast Cancer Res Treat. 2007 Jan;101(1):65-71 [16823510] Radiat Res. 2007 Jun;167(6):727-34 [17523852] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2000-7 [17932347] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2033-41 [17932351] Int J Cancer. 2008 Jan 1;122(1):177-82 [17764108] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.23779 ER - TY - JOUR T1 - Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. AN - 66717837; 19594501 AB - Attenuation of protein kinase C (PKC) is a mechanism common to both established (lithium, valproate) and some novel (tamoxifen) antimanic agents. Verapamil, although primarily known as a calcium channel blocker, also has PKC inhibitory activity. Verapamil has shown antimanic activity in some but not all studies. Therefore, we investigated verapamil, used alone or as an adjunctive treatment, in manic patients who did not respond to an initial adequate trial of lithium. Each study phase lasted three weeks. Subjects were treated openly with lithium in Phase 1 (n = 45). Those who failed to respond were randomly assigned to double-blind treatment in Phase 2 with either verapamil (n = 10) or continued-lithium (n = 8). Phase 2 nonresponders (n = 10) were assigned to combined verapamil/lithium in Phase 3. Response in Phase 2 did not differ significantly between verapamil and continued-lithium. During Phase 3, response to combined treatment was significantly better than overall response to monotherapy in Phase 2 (Fisher's Exact test, p = 0.043). Mania ratings improved during combined treatment in Phase 3 by 88.2% (linear mixed model analysis, F = 4.34, p = 0.013), compared with 10.5% improvement during Phase 2. In this preliminary investigation, verapamil monotherapy did not demonstrate antimanic efficacy. By contrast, the combination of verapamil plus lithium was highly efficacious. Our findings thus suggest that verapamil may have potential utility as an adjunct to lithium. This effect may be mediated by additive actions on PKC inhibition, which may be an important mechanism for antimanic agents in general. JF - Bipolar disorders AU - Mallinger, Alan G AU - Thase, Michael E AU - Haskett, Roger AU - Buttenfield, Joan AU - Luckenbaugh, David A AU - Frank, Ellen AU - Kupfer, David J AU - Manji, Husseini K AD - Mood and Anxiety Disorders Program, National Institutes of Health Intramural Research Program, Building 10, Room 3N210, MSC 1290, Bethesda, MD 20892, USA. mallingera@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 856 EP - 866 VL - 10 IS - 8 KW - Antimanic Agents KW - 0 KW - Antipsychotic Agents KW - Calcium Channel Blockers KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Verapamil KW - CJ0O37KU29 KW - Perphenazine KW - FTA7XXY4EZ KW - Index Medicus KW - Double-Blind Method KW - Antipsychotic Agents -- therapeutic use KW - Humans KW - Drug Resistance KW - Drug Therapy, Combination KW - Psychiatric Status Rating Scales KW - Perphenazine -- adverse effects KW - Adult KW - Middle Aged KW - Antipsychotic Agents -- adverse effects KW - Female KW - Male KW - Perphenazine -- therapeutic use KW - Lithium Carbonate -- therapeutic use KW - Verapamil -- adverse effects KW - Lithium Carbonate -- adverse effects KW - Calcium Channel Blockers -- adverse effects KW - Bipolar Disorder -- drug therapy KW - Antimanic Agents -- adverse effects KW - Bipolar Disorder -- psychology KW - Antimanic Agents -- therapeutic use KW - Verapamil -- therapeutic use KW - Calcium Channel Blockers -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66717837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bipolar+disorders&rft.atitle=Verapamil+augmentation+of+lithium+treatment+improves+outcome+in+mania+unresponsive+to+lithium+alone%3A+preliminary+findings+and+a+discussion+of+therapeutic+mechanisms.&rft.au=Mallinger%2C+Alan+G%3BThase%2C+Michael+E%3BHaskett%2C+Roger%3BButtenfield%2C+Joan%3BLuckenbaugh%2C+David+A%3BFrank%2C+Ellen%3BKupfer%2C+David+J%3BManji%2C+Husseini+K&rft.aulast=Mallinger&rft.aufirst=Alan&rft.date=2008-12-01&rft.volume=10&rft.issue=8&rft.spage=856&rft.isbn=&rft.btitle=&rft.title=Bipolar+disorders&rft.issn=1399-5618&rft_id=info:doi/10.1111%2Fj.1399-5618.2008.00636.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-03 N1 - Date created - 2009-07-14 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00518947; ClinicalTrials.gov N1 - SuppNotes - Cited By: Biol Psychiatry. 1999 Nov 15;46(10):1328-51 [10578449] Arch Gen Psychiatry. 2000 Jan;57(1):95-7 [10632242] Eur J Pharmacol. 2000 Feb 11;389(1):59-65 [10686296] Psychiatry Res. 2000 Feb 14;93(1):83-7 [10699232] J Clin Psychiatry. 2000;61 Suppl 9:5-15 [10826655] Biol Psychiatry. 2000 Sep 15;48(6):518-30 [11018224] J Affect Disord. 2000 Sep;59 Suppl 1:S31-S37 [11121825] Curr Psychiatry Rep. 2000 Dec;2(6):479-89 [11122999] Bipolar Disord. 2000 Sep;2(3 Pt 2):217-36 [11249800] Am J Psychiatry. 1992 Jan;149(1):118-20 [1728159] Minerva Med. 1991 Nov;82(11):757-63 [1766578] Eur J Pharmacol. 1991 Aug 6;200(2-3):353-6 [1782995] Brain Res. 1992 Jan 20;570(1-2):333-40 [1617424] Neuropharmacology. 1992 Dec;31(12):1201-10 [1361665] Neuropharmacology. 1992 Dec;31(12):1211-22 [1361666] Biol Psychiatry. 1993 Apr 1;33(7):520-5 [8513036] J Neurochem. 1993 Dec;61(6):2303-10 [8245981] Clin Pharmacol Ther. 1994 Jan;55(1):44-9 [8299315] Brain Res Mol Brain Res. 1993 Dec;20(4):289-98 [8114616] J Neurochem. 1994 Dec;63(6):2361-4 [7964759] Arch Gen Psychiatry. 1995 Jul;52(7):531-43 [7598629] Biol Psychiatry. 1996 Oct 1;40(7):568-75 [8886289] Curr Opin Cell Biol. 1997 Apr;9(2):161-7 [9069266] Synapse. 1997 Jul;26(3):281-91 [9183817] Am J Psychiatry. 1997 Jul;154(7):976-82 [9210749] J Pharmacol Exp Ther. 1997 Dec;283(3):1445-52 [9400020] J Pharmacol Exp Ther. 1998 Apr;285(1):307-16 [9536026] Exp Eye Res. 1998 Jul;67(1):45-52 [9702177] J Clin Psychopharmacol. 1998 Oct;18(5):404-13 [9790159] J Biol Chem. 1999 Apr 23;274(17):11447-50 [10206945] Neuroscience. 1999;91(2):771-6 [10366032] Biol Psychiatry. 1999 Jul 15;46(2):247-55 [10418700] J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 [14399272] Arch Gen Psychiatry. 2005 Sep;62(9):996-1004 [16143731] Psychoneuroendocrinology. 2006 May;31(4):543-7 [16356651] Biol Psychiatry. 2006 Jun 1;59(11):1006-20 [16487491] Biol Psychiatry. 2006 Jun 15;59(12):1160-71 [16457783] Nature. 2007 Jun 7;447(7145):661-78 [17554300] Bipolar Disord. 2007 Sep;9(6):561-70 [17845270] Neuropsychobiology. 2007;55(3-4):123-31 [17641532] Bipolar Disord. 2000 Jun;2(2):108-19 [11252650] Bipolar Disord. 2000 Dec;2(4):305-15 [11252642] Mol Psychiatry. 2008 Feb;13(2):197-207 [17486107] Biol Psychiatry. 2001 Sep 1;50(5):364-70 [11543740] Curr Psychiatry Rep. 2001 Dec;3(6):451-62 [11707158] Biol Psychiatry. 2002 May 1;51(9):745-52 [11983188] Am J Obstet Gynecol. 2002 Dec;187(6):1711-2 [12501088] Neuropsychopharmacology. 2004 Apr;29(4):759-69 [14970832] Science. 2004 Oct 29;306(5697):882-4 [15514161] J Nerv Ment Dis. 1969 Jan;148(1):87-98 [5768895] Acta Psychiatr Scand. 1979 Apr;59(4):420-30 [433633] J Biol Chem. 1980 Nov 25;255(22):10896-901 [6253491] J Neurochem. 1981 Jun;36(6):1947-51 [6264039] Biochem J. 1982 Sep 15;206(3):587-95 [7150264] J Clin Pharmacol. 1986 Nov-Dec;26(8):717-9 [3793965] J Am Geriatr Soc. 1987 Feb;35(2):177-8 [3100605] J Clin Psychiatry. 1987 Sep;48(9):371-2 [3114243] Nature. 1988 Feb 4;331(6155):388 [3123995] Nature. 1988 Feb 4;331(6155):440-2 [3340189] Arch Gen Psychiatry. 1989 Jul;46(7):632-8 [2735813] J Clin Psychopharmacol. 1989 Dec;9(6):454-5 [2512332] Psychopharmacol Bull. 1991;27(1):17-22 [1862201] Biol Psychiatry. 1991 Sep 15;30(6):635-6 [1932412] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1399-5618.2008.00636.x ER - TY - JOUR T1 - Host-environment interactions in exposure-related diffuse lung diseases. AN - 66689953; 19221958 AB - Diffuse lung disease (DLD), also known as interstitial lung disease (ILD), comprises a group of relatively rare but devastating lung diseases that involve varying degrees of acute and chronic inflammation, and which may present with end-stage fibroproliferation. There are currently no proven therapeutic strategies to halt progression of DLDs. Thinking about DLDs has evolved over time from hypotheses invoking inflammation as the prime mover in the etiology of disease, to the current hypothesis that interactions between a damaged and frustrated epithelium, and the response of underlying mesenchymal cells that takes place, contribute to the fibroproliferative milieu. The greatest challenge to understanding the role of environmental exposures in pathogenesis of DLDs is that there is no clear consensus on the etiology and pathogenesis of these diseases. Emerging data on the relationship between loss of epithelial integrity and mesenchymal fibroproliferation support the hypothesis that the damage to the epithelium is a critical component in the development of DLDs that progress to a fibroproliferative presentation. Thus it follows that environmental stress which impacts the well-being of the epithelium may play a critical role in shifting the balance of lung homeostasis through ongoing insult as a result of exposure to environmental agents. Animal models that recapitulate the vulnerable epithelium observed in patients who develop fibrotic lung disease associated with DLDs will provide the best opportunity to understand mechanisms associated with the etiology of these diseases. JF - Seminars in respiratory and critical care medicine AU - Brass, David M AU - Wise, Anastasia L AU - Schwartz, David A AD - National Heart Lung and Blood Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. David.brass@duke.edu Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 603 EP - 609 VL - 29 IS - 6 KW - Index Medicus KW - Animals KW - Humans KW - Disease Progression KW - Disease Models, Animal KW - Mesenchymal Stromal Cells -- metabolism KW - Epithelium -- pathology KW - Homeostasis -- drug effects KW - Epithelium -- drug effects KW - Pulmonary Fibrosis -- etiology KW - Pulmonary Fibrosis -- physiopathology KW - Lung Diseases, Interstitial -- etiology KW - Lung Diseases, Interstitial -- physiopathology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66689953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+respiratory+and+critical+care+medicine&rft.atitle=Host-environment+interactions+in+exposure-related+diffuse+lung+diseases.&rft.au=Brass%2C+David+M%3BWise%2C+Anastasia+L%3BSchwartz%2C+David+A&rft.aulast=Brass&rft.aufirst=David&rft.date=2008-12-01&rft.volume=29&rft.issue=6&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=Seminars+in+respiratory+and+critical+care+medicine&rft.issn=1098-9048&rft_id=info:doi/10.1055%2Fs-0028-1101270 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2009-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-0028-1101270 ER - TY - JOUR T1 - Striving for Control: Cognitive, Self-Care, and Faith Strategies Employed by Vulnerable Black and White Older Adults with Multiple Chronic Conditions AN - 61774796; 200921096 AB - The average older adult reaches age 65 with at least two chronic, co-occurring illnesses, or multiple morbidities (MM). We currently lack critical information about the specific strategies older adults use to attempt to control these MM. To increase our understanding of how older adults attempt to manage these MM and retain control of their health, in-depth interviews were conducted with 41 Black and White middle aged and older men and women with MM. We were particularly interested in representing the experience of those groups more vulnerable to adverse health outcomes due to greater disease prevalence and low income. During in-depth interviews, we asked open-ended questions on life and health history and open-ended and semi-structured questions about self-care for multiple morbidities. Participants expressed a strong desire to remain in control of their health; to do so they employed a wide range of strategies including cognitive structuring techniques (being health vigilant, normalizing, resignation/relinquishing control, and social comparison), self-care activities (emphasizing diet, exercise, medication taking, modifying existing activities, going to the doctor), and faith orientations (prayer as a constructive support strategy, gaining strength from God, church as a central part of life). With the exception of faith orientations, there were no race/ethnicity differences in the strategies participants use. Future studies should expand on this knowledge by exploring the contextual, cultural, and psychological backdrop and characteristics that shape the use of these coping strategies. Adapted from the source document. JF - Journal of Cross-Cultural Gerontology AU - Leach, Corinne R AU - Schoenberg, Nancy E AD - Cancer Prevention Fellow, National Cancer Institute and Master of Public Health Student, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA cleach@hsph.harvard.edu Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 377 EP - 399 PB - Springer, Dordrecht The Netherlands VL - 23 IS - 4 SN - 0169-3816, 0169-3816 KW - Self Care KW - Chronic Illness KW - Religiosity KW - Elderly KW - Health KW - Diseases KW - Coping KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61774796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Gerontology&rft.atitle=Striving+for+Control%3A+Cognitive%2C+Self-Care%2C+and+Faith+Strategies+Employed+by+Vulnerable+Black+and+White+Older+Adults+with+Multiple+Chronic+Conditions&rft.au=Leach%2C+Corinne+R%3BSchoenberg%2C+Nancy+E&rft.aulast=Leach&rft.aufirst=Corinne&rft.date=2008-12-01&rft.volume=23&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Gerontology&rft.issn=01693816&rft_id=info:doi/10.1007%2Fs10823-008-9086-2 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-05-04 N1 - Number of references - 66 N1 - Last updated - 2016-09-28 N1 - CODEN - JCCGEB N1 - SubjectsTermNotLitGenreText - Chronic Illness; Elderly; Diseases; Health; Self Care; Coping; Religiosity DO - http://dx.doi.org/10.1007/s10823-008-9086-2 ER - TY - JOUR T1 - A tailored internet-plus-email intervention for increasing physical activity among ethnically-diverse women AN - 57304033; 200918490 AB - Objective To evaluate the feasibility and efficacy of an individually tailored, Internet-plus-email physical activity intervention designed for adult women. Method Healthy and ethnically-diverse adult females (N = 156) (mean age = 42.8 years, 65% Caucasian) from California were randomly assigned to an intervention (access to a tailored website and weekly emails) or wait-list control group. Participants completed web-based assessments of physical activity, stage of behavior change, and psychosocial variables at baseline, one month, two months, and three months. Data were collected during 2006 -2007. Multilevel random coefficient modeling examined group differences in rates of change. Results As compared to the control condition, the intervention group increased walking (+ 69 versus + 32 min per week) and total moderate-to-vigorous physical activity (+ 23 versus - 25 min per week) after three months. The intervention did not impact stage of behavior change or any of the other psychosocial variables. Conclusion A tailored, Internet-based intervention for adult women had a positive effect on walking and moderate-to-vigorous physical activity in an ethnically-diverse sample. However, given the lack of comparable research contact in the control group, these findings should be taken cautiously. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Dunton, Genevieve Fridlund AU - Robertson, Trina P AD - Health Promotion Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20852, USA Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 605 EP - 611 PB - Elsevier Ltd, The Netherlands VL - 47 IS - 6 SN - 0091-7435, 0091-7435 KW - Exercise Walking Intervention Internet Women Compliance KW - Web sites KW - Electronic mail systems KW - Physical activity KW - Behavioural changes KW - Women KW - Psychosocial factors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57304033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=A+tailored+internet-plus-email+intervention+for+increasing+physical+activity+among+ethnically-diverse+women&rft.au=Dunton%2C+Genevieve+Fridlund%3BRobertson%2C+Trina+P&rft.aulast=Dunton&rft.aufirst=Genevieve&rft.date=2008-12-01&rft.volume=47&rft.issue=6&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2008.10.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Physical activity; Women; Behavioural changes; Psychosocial factors; Electronic mail systems; Web sites DO - http://dx.doi.org/10.1016/j.ypmed.2008.10.004 ER - TY - JOUR T1 - Nutrition-Related Cancer Prevention Cognitions and Behavioral Intentions: Testing the Risk Perception Attitude Framework AN - 57276723; 200904990 AB - This study tested whether the risk perception attitude framework predicted nutrition-related cancer prevention cognitions and behavioral intentions. Data from the 2003 Health Information National Trends Survey were analyzed to assess respondents'reported likelihood of developing cancer (risk) and perceptions of whether they could lower their chances of getting cancer (efficacy). Respondents with higher efficacy were more likely to report that good nutrition can prevent cancer, and they reported more preventive dietary changes, as compared to respondents with lower efficacy. Respondents with higher efficacy were more likely to report intentions to change their diets to prevent cancer, and they reported more preventive dietary changes to their own diets but only at higher levels of risk. Results suggest that to improve cognitions about the role of nutrition in cancer prevention, interventions should target cancer prevention efficacy; however, to increase intentions to change nutrition behaviors, interventions should target efficacy and risk perceptions. [Reprinted by permission of Sage Publications Inc., copyright 2008, Society for Public Health Education.] JF - Health Education & Behavior AU - Sullivan, Helen W AU - Beckjord, Ellen Burke AU - Rutten, Lila J Finney AU - Hesse, Bradford W AD - National Cancer Institute, Bethesda, Maryland Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 866 EP - 879 PB - Sage Publications, Thousand Oaks CA VL - 35 IS - 6 SN - 1090-1981, 1090-1981 KW - risk perception attitude framework KW - Health Information National Trends Survey KW - cancer prevention KW - Preventive strategies KW - Health beliefs KW - Intention KW - Risk perception KW - Cancer KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Nutrition-Related+Cancer+Prevention+Cognitions+and+Behavioral+Intentions%3A+Testing+the+Risk+Perception+Attitude+Framework&rft.au=Sullivan%2C+Helen+W%3BBeckjord%2C+Ellen+Burke%3BRutten%2C+Lila+J+Finney%3BHesse%2C+Bradford+W&rft.aulast=Sullivan&rft.aufirst=Helen&rft.date=2008-12-01&rft.volume=35&rft.issue=6&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198108326164 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Cancer; Health beliefs; Risk perception; Preventive strategies; Health behaviour; Intention DO - http://dx.doi.org/10.1177/1090198108326164 ER - TY - JOUR T1 - Risk for Bipolar Disorder Is Associated With Face-Processing Deficits Across Emotions AN - 57272391; 200901234 AB - Objective: Youths with euthymic bipolar disorder (BD) have a deficit in face-emotion labeling that is present across multiple emotions. Recent research indicates that youths at familial risk for BD, but without a history of mood disorder, also have a deficit in face-emotion labeling, suggesting that such impairments may be an endophenotype for BD. It is unclear whether this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest. Method: Thirty-seven patients with pediatric BD, 25 unaffected children with a first-degree relative with BD, and 36 typically developing youths were administered the Emotional Expression Multimorph Task, a computerized behavioral task, which presents gradations of facial emotions from 100% neutrality to 100% emotional expression (happiness, surprise, fear, sadness, anger, and disgust). Results: Repeats d measures analysis of covariance revealed that, compared with the control youths, the patients and the at-risk youths required significantly more intense emotional information to identify and correctly label face emotions. The patients with BD and the at-risk youths did not differ from each other. Group-by-emotion interactions were not significant, indicating that the group effects did not differ based on the facial emotion. Conclusions: The youths at risk for BD demonstrate nonspecific deficits in face-emotion recognition, similar to patients with the illness. Further research is needed to determine whether such deficits meet all the criteria for an endophenotype. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Brotman, Melissa A AU - Skup, Martha AU - Rich, Brendan A AU - Blair, Karina S AU - Pine, Daniel S AU - Blair, James R AU - Leibenluft, Ellen AD - 15K North Drive, Room 208, Bethesda, MD 20892 brotmanm@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1455 EP - 1461 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 12 SN - 0890-8567, 0890-8567 KW - bipolar disorder, endophenotype, face emotion labeling, at risk KW - Paediatrics KW - Emotions KW - Bipolar affective disorder KW - Young people KW - Phenotypes KW - At risk KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57272391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Risk+for+Bipolar+Disorder+Is+Associated+With+Face-Processing+Deficits+Across+Emotions&rft.au=Brotman%2C+Melissa+A%3BSkup%2C+Martha%3BRich%2C+Brendan+A%3BBlair%2C+Karina+S%3BPine%2C+Daniel+S%3BBlair%2C+James+R%3BLeibenluft%2C+Ellen&rft.aulast=Brotman&rft.aufirst=Melissa&rft.date=2008-12-01&rft.volume=47&rft.issue=12&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e318188832e LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Young people; Emotions; At risk; Bipolar affective disorder; Paediatrics; Phenotypes DO - http://dx.doi.org/10.1097/CHI.0b013e318188832e ER - TY - JOUR T1 - Recent NIMH Clinical Trials and Implications for Practice AN - 57264986; 200902755 AB - More than 10 years ago, the National Institute of Mental Health (NIMH) started a program of multisite clinical trials with the purpose of providing clinicians, patients, and families with the scientific evidence necessary for making informed treatment decisions in child and adolescent psychiatry.1 The focus was on treatments already used in clinical practice but without adequate evidence of efficacy and safety. The specific aim of each trial varied according to the state of the science of the disorder being treated and the particular treatment being tested. Thus, for medications in need of efficacy evaluation, and often used off-label in the community, as was the case for the selective serotonin reuptake inhibitor (SSRI) antidepressants in pediatric anxiety disorders or for the second-generation antipsychotics in autism, straightforward placebo-controlled trials were conducted.2,3 When efficacy had been demonstrated, however, trials were launched to directly compare the relative benefits of active treatments and to assess the possible advantage of combined treatment versus monotherapy. The main findings of NIMH-funded, multisite, randomized clinical trials completed in the last 5 years are here briefly reviewed, and their implications for practice are discussed (Table 1). Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Vitiello, Benedetto AD - National Institute of Mental Health, Room 7147, 6001 Executive Blvd., Bethesda, MD 20892-9633 bvitiell@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1369 EP - 1374 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 12 SN - 0890-8567, 0890-8567 KW - Paediatrics KW - Efficacy KW - Antidepressant drugs KW - Psychiatry KW - Clinical trials KW - Treatment needs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57264986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Recent+NIMH+Clinical+Trials+and+Implications+for+Practice&rft.au=Vitiello%2C+Benedetto&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2008-12-01&rft.volume=47&rft.issue=12&rft.spage=1369&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31818960a7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Efficacy; Antidepressant drugs; Clinical trials; Treatment needs; Paediatrics; Psychiatry DO - http://dx.doi.org/10.1097/CHI.0b013e31818960a7 ER - TY - JOUR T1 - Methylphenidate and Amphetamine Do Not Induce Cytogenetic Damage in Lymphocytes of Children With ADHD AN - 57249227; 200902837 AB - Objective: In response to previously published findings of methylphenidate-induced chromosomal changes in children, this study was designed to determine whether methylphenidate- or amphetamine-based drugs induce chromosomal damage (structural aberrations, micronuclei, and sister chromatid exchanges) in peripheral blood lymphocytes of children with attention-deficit/hyperactivity disorder after 3 months of continuous treatment. Method: Stimulant drug-naive subjects, 6 to 12 years of age, in good overall health, and judged to be appropriate candidates for stimulant therapy based on rigorously diagnosed ADHD using DSM-IV criteria, were randomized into two open-label treatment groups (methylphenidate or mixed amphetamine salts). Each subject provided a blood sample before initiation of treatment and after 3 months of treatment. Pretreatment and posttreatment frequencies of chromosomal aberrations, micronuclei, and sister chromatid exchanges were determined for each subject. Results: Sixty-three subjects enrolled in the study; 47 subjects completed the full 3 months of treatment, 25 in the methylphenidate group and 22 in the amphetamine group. No significant treatment-related increases were observed in any of the three measures of cytogenetic damage in the 47 subjects who completed treatment or the 16 subjects who did not. Conclusions: Earlier findings of methylphenidate-induced chromosomal changes in children were not replicated in this study. These results add to the accumulating evidence that therapeutic levels of methylphenidate do not induce cytogenetic damage in humans. Furthermore, our results indicate that amphetamine-based products do not pose a risk for cytogenetic damage in children. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Witt, Kristine L AU - Shelby, Michael D AU - Itchon-Ramos, Nilda AU - Faircloth, Melissa AU - Kissling, Grace E AU - Chrisman, Allan K AU - Ravi, Hima AU - Murli, Hemalatha AU - Mattison, Donald R AU - Kollins, Scott H AD - National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop EC-32, 79 TW Alexander Drive, Suite 100, Room 159A, Research Triangle Park, NC 27709 witt@niehs.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1375 EP - 1383 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 12 SN - 0890-8567, 0890-8567 KW - stimulant drugs, micronuclei, chromosome aberrations, sister chromatid exchanges, cohort study, Clinical trial registration information, Genetic Measurements in Blood Cells of Children Taking Adderall or Methylphenidate KW - Amphetamines KW - Immunology KW - Attention deficit hyperactivity disorder KW - Methylphenidate KW - Children KW - Side effects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57249227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Methylphenidate+and+Amphetamine+Do+Not+Induce+Cytogenetic+Damage+in+Lymphocytes+of+Children+With+ADHD&rft.au=Witt%2C+Kristine+L%3BShelby%2C+Michael+D%3BItchon-Ramos%2C+Nilda%3BFaircloth%2C+Melissa%3BKissling%2C+Grace+E%3BChrisman%2C+Allan+K%3BRavi%2C+Hima%3BMurli%2C+Hemalatha%3BMattison%2C+Donald+R%3BKollins%2C+Scott+H&rft.aulast=Witt&rft.aufirst=Kristine&rft.date=2008-12-01&rft.volume=47&rft.issue=12&rft.spage=1375&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e3181893620 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Children; Methylphenidate; Amphetamines; Attention deficit hyperactivity disorder; Side effects; Immunology DO - http://dx.doi.org/10.1097/CHI.0b013e3181893620 ER - TY - JOUR T1 - Systematic review of public health branding AN - 37021417; 3805627 AB - Brands build relationships between consumers and products, services, or lifestyles by providing beneficial exchanges and adding value to their objects. Brands can be measured through associations that consumers hold for products and services. Public health brands are the associations that individuals hold for health behaviors, or lifestyles that embody multiple health behaviors. We systematically reviewed the literature on public health brands; developed a methodology for describing branded health messages and campaigns; and examined specific branding strategies across a range of topic areas, campaigns, and global settings. We searched the literature for published studies on public health branding available through all relevant, major online publication databases. Public health branding was operationalized as any manuscripts in the health, social science, and business literature on branding or brands in health promotion marketing. We developed formalized decision rules and applied them in identifying articles for review. We initially identified 154 articles and reviewed a final set of 37, 10 from Africa, Australia, and Europe. Branded health campaigns spanned most of the major domains of public health and numerous communication strategies and evaluation methodologies. Most studies provided clear information on planning, development, and evaluation of the branding effort, while some provided minimal information. Branded health messages typically are theory based, and there is a body of evidence on their behavior change effectiveness, especially in nutrition, tobacco control, and HIV/AIDS. More rigorous research is needed, however, on how branded health messages impact specific populations and behaviors. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Evans, W Douglas AU - Blitstein, Jonathan AU - Hersey, James AU - Renaud, Jeanette AU - Yaroch, Amy AD - Research Triangle Institute International ; National Cancer Institute Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 721 EP - 741 VL - 13 IS - 8 SN - 1081-0730, 1081-0730 KW - Economics KW - Sociology KW - Medical research KW - AIDS KW - Marketing KW - Diseases KW - HIV KW - Information dissemination KW - Illness KW - Brands KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37021417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Systematic+review+of+public+health+branding&rft.au=Evans%2C+W+Douglas%3BBlitstein%2C+Jonathan%3BHersey%2C+James%3BRenaud%2C+Jeanette%3BYaroch%2C+Amy&rft.aulast=Evans&rft.aufirst=W&rft.date=2008-12-01&rft.volume=13&rft.issue=8&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730802487364 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10449 5772; 1757 7738 11245 11239; 7738 11245 11239; 6520; 5703 3617 6220; 482 3617 6220; 7886 10902; 6220; 3617 6220 DO - http://dx.doi.org/10.1080/10810730802487364 ER - TY - JOUR T1 - Occupational practices and the making of health news: a national survey of U.S. health and medical science journalists AN - 37021029; 3805629 AB - News media coverage of health topics can frame and heighten the salience of health-related issues, thus influencing the public's beliefs, attitudes, and behaviors. Through their routine coverage of scientific developments, news media are a critical intermediary in translating research for the public, patients, practitioners, and policymakers. Until now, little was known about how health and medical science reporters and editors initiate, prioritize, and develop news stories related to health and medicine. We surveyed 468 reporters and editors representing 463 local and national broadcast and print media outlets to characterize individual characteristics and occupational practices leading to the development of health and medical science news. Our survey revealed that 70% of respondents had bachelor's degrees; 8% were life sciences majors in college. Minorities are underrepresented in health journalism; 97% of respondents were non-Hispanic and 93% were White. Overall, initial ideas for stories come from a "news source" followed by press conferences or press releases. Regarding newsworthiness criteria, the "potential for public impact" and "new information or development" are the major criteria cited, followed by "ability to provide a human angle" and "ability to provide a local angle." Significant differences were seen between responses from reporters vs. editors and print vs. broadcast outlets. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Viswanath, K AU - Blake, Kelly AU - Meissner, Helen AU - Saiontz, Nicole Gottlieb AU - Mull, Corey AU - Freeman, Carol AU - Hesse, Bradford AU - Croyle, Robert AD - Harvard University ; National Institutes of Health ; National Cancer Institute ; ORC Macro International Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 759 EP - 777 VL - 13 IS - 8 SN - 1081-0730, 1081-0730 KW - Sociology KW - Media KW - Minorities KW - Survey data KW - U.S.A. KW - Information dissemination KW - News KW - Press releases KW - Journalism KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37021029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Occupational+practices+and+the+making+of+health+news%3A+a+national+survey+of+U.S.+health+and+medical+science+journalists&rft.au=Viswanath%2C+K%3BBlake%2C+Kelly%3BMeissner%2C+Helen%3BSaiontz%2C+Nicole+Gottlieb%3BMull%2C+Corey%3BFreeman%2C+Carol%3BHesse%2C+Bradford%3BCroyle%2C+Robert&rft.aulast=Viswanath&rft.aufirst=K&rft.date=2008-12-01&rft.volume=13&rft.issue=8&rft.spage=759&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730802487430 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10449 5772; 12427 12429; 10067; 8122; 8669 6515; 6520; 6999; 7862 2572; 433 293 14 DO - http://dx.doi.org/10.1080/10810730802487430 ER - TY - JOUR T1 - Semiparametric two-sample changepoint model with application to human immunodeficiency virus studies AN - 37006353; 3793384 AB - A two-sample changepoint model is proposed to investigate the difference between two treatments or devices. Under our semiparametric approach, no assumptions are made about the underlying distributions of the measurements from the two treatments or devices, but a parametric link is assumed between the two. The parametric link contains the possible changepoint where the two distributions start to differ. We apply the maximum empirical likelihood for model estimation and show the consistency of the changepoint estimator. An extended changepoint model is studied to handle data censored because of detection limits in viral load assays of human immunodeficiency virus (HIV). Permutation and bootstrap procedures are proposed to test the existence of a changepoint and the goodness of fit of the model. The performance of the semiparametric changepoint model is compared with that of parametric models in a simulation study. We provide two applications in HIV studies: one is a randomized placebo-controlled study to evaluated the effects of a recombinant glycoprotein 120 vaccine on HIV viral load; the other is a study to compare two types of tubes in handling plasma samples for viral load determination. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Hu, Z. AU - Qin, J AU - Follmann, D AD - National Institute of Allergy and Infectious Diseases Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 589 EP - 608 VL - 57 IS - 5 SN - 0035-9254, 0035-9254 KW - Sociology KW - Statistics KW - Medical research KW - Distribution KW - Maximum likelihood method KW - HIV KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37006353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Semiparametric+two-sample+changepoint+model+with+application+to+human+immunodeficiency+virus+studies&rft.au=Hu%2C+Z.%3BQin%2C+J%3BFollmann%2C+D&rft.aulast=Hu&rft.aufirst=Z.&rft.date=2008-12-01&rft.volume=57&rft.issue=5&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12233; 12228 10919; 7886 10902; 7837 8160 8163 12230; 5703 3617 6220; 3641 12233 ER - TY - JOUR T1 - The Early Phagosomal Stage of Francisella tularensis Determines Optimal Phagosomal Escape and Francisella Pathogenicity Island Protein Expression AN - 21508609; 12495322 AB - Francisella tularensis is an intracellular pathogen that can survive and replicate within macrophages. Following phagocytosis and transient interactions with the endocytic pathway, F. tularensis rapidly escapes from its original phagosome into the macrophage cytoplasm, where it eventually replicates. To examine the importance of the nascent phagosome for the Francisella intracellular cycle, we have characterized early trafficking events of the F. tularensis subsp. tularensis strain Schu S4 in a murine bone marrow-derived macrophage model. Here we show that early phagosomes containing Schu S4 transiently interact with early and late endosomes and become acidified before the onset of phagosomal disruption. Inhibition of endosomal acidification with the vacuolar ATPase inhibitor bafilomycin A1 or concanamycin A prior to infection significantly delayed but did not block phagosomal escape and cytosolic replication, indicating that maturation of the early Francisella-containing phagosome (FCP) is important for optimal phagosomal escape and subsequent intracellular growth. Further, Francisella pathogenicity island (FPI) protein expression was induced during early intracellular trafficking events. Although inhibition of endosomal acidification mimicked the early phagosomal escape defects caused by mutation of the FPI-encoded IglCD proteins, it did not inhibit the intracellular induction of FPI proteins, demonstrating that this response is independent of phagosomal pH. Altogether, these results demonstrate that early phagosomal maturation is required for optimal phagosomal escape and that the early FCP provides cues other than intravacuolar pH that determine intracellular induction of FPI proteins. JF - Infection and Immunity AU - Chong, Audrey AU - Wehrly, Tara D AU - Nair, Vinod AU - Fischer, Elizabeth R AU - Barker, Jeffrey R AU - Klose, Karl E AU - Celli, Jean AD - Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, jcelli@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 5488 EP - 5499 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 12 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Adenosinetriphosphatase KW - Replication KW - Concanamycin A KW - Phagosomes KW - Animal models KW - Bone marrow KW - Francisella tularensis KW - Pathogens KW - Infection KW - pathogenicity islands KW - endosomes KW - Cytoplasm KW - Acidification KW - Phagocytosis KW - pH effects KW - Mutation KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21508609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Early+Phagosomal+Stage+of+Francisella+tularensis+Determines+Optimal+Phagosomal+Escape+and+Francisella+Pathogenicity+Island+Protein+Expression&rft.au=Chong%2C+Audrey%3BWehrly%2C+Tara+D%3BNair%2C+Vinod%3BFischer%2C+Elizabeth+R%3BBarker%2C+Jeffrey+R%3BKlose%2C+Karl+E%3BCelli%2C+Jean&rft.aulast=Chong&rft.aufirst=Audrey&rft.date=2008-12-01&rft.volume=76&rft.issue=12&rft.spage=5488&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00682-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Macrophages; Adenosinetriphosphatase; Replication; Concanamycin A; Phagosomes; Bone marrow; Animal models; Pathogens; Infection; pathogenicity islands; endosomes; Cytoplasm; Acidification; Phagocytosis; Mutation; pH effects; Francisella tularensis DO - http://dx.doi.org/10.1128/IAI.00682-08 ER - TY - JOUR T1 - Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin AN - 21391191; 8782665 AB - Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of unknown protein(s) by the proteasome, formation of the Nalp1b (NLRP1b) inflammasome and subsequent activation of caspase-1. We report that heat-shocking LT-sensitive macrophages rapidly protects them against cytolysis by inhibiting caspase-1 activation without upstream effects on LT endocytosis or cleavage of the toxin's known cytosolic substrates (mitogen-activated protein kinases). Heat shock protection against LT occurred through a mechanism independent of de novo protein synthesis, HSP90 activity, p38 activation or proteasome inhibition and was downstream of mitogen-activated protein kinase cleavage and degradation of an unknown substrate by the proteasome. The heat shock inhibition of LT-mediated caspase-1 activation was not specific to the Nalp1b (NLRP1b) inflammasome, as heat shock also inhibited Nalp3 (NLRP3) inflammasome-mediated caspase-1 activation in macrophages. We found that heat shock induced pro-caspase-1 association with a large cellular complex that could prevent its activation. Additionally, while heat-shocking recombinant caspase-1 did not affect its activity in vitro, lysates from heat-shocked cells completely inhibited recombinant active caspase-1 activity. Our results suggest that heat shock inhibition of active caspase-1 can occur independently of an inflammasome platform, through a titratable factor present within intact, functioning heat-shocked cells. JF - Cellular Microbiology AU - Levin, Tera C AU - Wickliffe, Katherine E AU - Leppla, Stephen H AU - Moayeri, Mahtab AD - Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD20892, USA., mmoayeri@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2434 EP - 2446 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 10 IS - 12 SN - 1462-5814, 1462-5814 KW - Toxicology Abstracts KW - Macrophages KW - Hsp90 protein KW - Anthrax lethal toxin KW - Endocytosis KW - MAP kinase KW - Protein biosynthesis KW - proteasomes KW - Cytolysis KW - Heat shock KW - Caspase-1 KW - Cell activation KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21391191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Heat+shock+inhibits+caspase-1+activity+while+also+preventing+its+inflammasome-mediated+activation+by+anthrax+lethal+toxin&rft.au=Levin%2C+Tera+C%3BWickliffe%2C+Katherine+E%3BLeppla%2C+Stephen+H%3BMoayeri%2C+Mahtab&rft.aulast=Levin&rft.aufirst=Tera&rft.date=2008-12-01&rft.volume=10&rft.issue=12&rft.spage=2434&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2008.01220.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Hsp90 protein; Macrophages; Endocytosis; Anthrax lethal toxin; MAP kinase; Protein biosynthesis; Cytolysis; proteasomes; Heat shock; Caspase-1; Cell activation DO - http://dx.doi.org/10.1111/j.1462-5822.2008.01220.x ER - TY - JOUR T1 - Benefit in phase 1 oncology trials: therapeutic misconception or reasonable treatment option? AN - 21342690; 9398754 AB - Novel treatments for cancer are tested initially in phase 1 trials enrolling patients with advanced disease who have exhausted standard treatment options. Although these trials are designed to evaluate safety and to define dosing for future efficacy trials, most patients volunteer with the hope of obtaining medical benefit. Do phase 1 oncology trials promote a `therapeutic misconception' among eligible patients about the personal meaning of trial participation, or do they offer them a reasonable prospect of direct medical benefit as compared with available alternatives? Recent evidence on outcomes of phase 1 oncology trials is examined systematically, with the aim of accurately assessing the prospect of direct medical benefit for participants and drawing implications for informed consent. We argue that, in view of important uncertainties, aggregate data from phase 1 trials relating to the surrogate outcomes of tumor shrinkage and stable disease do not permit any definitive estimate of a `clinical benefit rate.' Nevertheless, these trials do offer participants a prospect of direct medical benefit. As a result, accurately informed patients may reasonably decide to enroll in phase 1 oncology trials in hopes of obtaining benefit, after considering the anticipated risks and available clinical alternatives. Motivation to enroll in these studies to receive personal benefit does not, in itself, compromise informed consent. JF - Clinical Trials AU - Miller, Franklin G AU - Joffe, Steven AD - Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA, fmiller@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 617 EP - 623 PB - Sage Publications Ltd., 6 Bonhill St. VL - 5 IS - 6 SN - 1740-7745, 1740-7745 KW - Health & Safety Science Abstracts; Risk Abstracts KW - tumors KW - clinical trials KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21342690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Benefit+in+phase+1+oncology+trials%3A+therapeutic+misconception+or+reasonable+treatment+option%3F&rft.au=Miller%2C+Franklin+G%3BJoffe%2C+Steven&rft.aulast=Miller&rft.aufirst=Franklin&rft.date=2008-12-01&rft.volume=5&rft.issue=6&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774508097576 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - tumors; clinical trials; Cancer DO - http://dx.doi.org/10.1177/1740774508097576 ER - TY - JOUR T1 - Human tumor-associated viruses and new insights into the molecular mechanisms of cancer AN - 21309623; 11937531 AB - The study of acute-transforming retroviruses and their oncogenes and of the multiple mechanisms deployed by DNA viruses to circumvent the growth-suppressive and proapoptotic function of tumor suppressor genes has provided the foundation of our current understanding of cancer biology. Unlike acute-transforming animal viruses, however, human tumor-associated viruses lead to malignancies with a prolonged latency and in conjunction with other environmental and host-related cooperating events. The relevance of viral infection to human cancer development has often been debated. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Hence, the opportunity exists to fight cancer at the global scale by preventing the spread of these viruses, by the development and distribution of effective and safe antiviral vaccines, and by identifying their oncogenic mechanism. Here, we discuss the molecular events underlying the neoplastic potential of the human tumor-associated viruses, with emphasis on the enigmatic KSHV and its numerous virally hijacked proangiogenic, immune-evasive and tumor-promoting genes. The emerging information may facilitate the development of new molecular-targeted approaches to prevent and treat virally associated human malignancies. JF - Oncogene AU - Martin, D AU - Gutkind, J S AD - Cell Growth Regulation Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - S31 EP - S42 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 27 IS - S2 SN - 0950-9232, 0950-9232 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Oncogenes & Growth Factors Abstracts KW - Human T-lymphotropic virus KW - Molecular modelling KW - Tumor suppressor genes KW - Apoptosis KW - Hepatitis B virus KW - Human T-lymphotropic virus 1 KW - Kaposi's sarcoma-associated herpesvirus KW - Infection KW - DNA viruses KW - Epstein-Barr virus KW - Malignancy KW - Retrovirus KW - Oncogenes KW - Hepatitis C virus KW - Lymphocytes T KW - Sarcoma KW - Vaccines KW - Human papillomavirus KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - B 26650:Viral Oncogenes KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21309623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Human+tumor-associated+viruses+and+new+insights+into+the+molecular+mechanisms+of+cancer&rft.au=Martin%2C+D%3BGutkind%2C+J+S&rft.aulast=Martin&rft.aufirst=D&rft.date=2008-12-01&rft.volume=27&rft.issue=S2&rft.spage=S31&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fonc.2009.351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Molecular modelling; Malignancy; Apoptosis; Oncogenes; Sarcoma; Lymphocytes T; Vaccines; Infection; DNA viruses; Human T-lymphotropic virus; Epstein-Barr virus; Retrovirus; Hepatitis C virus; Hepatitis B virus; Human T-lymphotropic virus 1; Kaposi's sarcoma-associated herpesvirus; Human papillomavirus DO - http://dx.doi.org/10.1038/onc.2009.351 ER - TY - JOUR T1 - Three-dimensional water diffusion in impermeable cylindrical tubes: theory versus experiments AN - 21069520; 8632367 AB - Characterizing diffusion of gases and liquids within pores is important in understanding numerous transport processes and affects a wide range of practical applications. Previous measurements of the pulsed gradient stimulated echo (PGSTE) signal attenuation, E(q), of water within nerves and impermeable cylindrical microcapillary tubes showed it to be exquisitely sensitive to the orientation of the applied wave vector, q, with respect to the tube axis in the high-q regime. Here, we provide a simple three-dimensional model to explain this angular dependence by decomposing the average propagator, which describes the net displacement of water molecules, into components parallel and perpendicular to the tube wall, in which axial diffusion is free and radial diffusion is restricted. The model faithfully predicts the experimental data, not only the observed diffraction peaks in E(q) when the diffusion gradients are approximately normal to the tube wall, but their sudden disappearance when the gradient orientation possesses a small axial component. The model also successfully predicts the dependence of E(q) on gradient pulse duration and on gradient strength as well as tube inner diameter. To account for the deviation from the narrow pulse approximation in the PGSTE sequence, we use Callaghan's matrix operator framework, which this study validates experimentally for the first time. We also show how to combine average propagators derived for classical one-dimensional and two-dimensional models of restricted diffusion (e.g. between plates, within cylinders) to construct composite three-dimensional models of diffusion in complex media containing pores (e.g. rectangular prisms and/or capped cylinders) having a distribution of orientations, sizes, and aspect ratios. This three-dimensional modeling framework should aid in describing diffusion in numerous biological systems and in a myriad of materials sciences applications. JF - NMR in Biomedicine AU - Avram, Liat AU - Ozarslan, Evren AU - Assaf, Yaniv AU - Bar-Shir, Amnon AU - Cohen, Yoram AU - Basser, Peter J AD - School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, Israel, pjbasser@helix.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 888 EP - 898 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 21 IS - 8 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Nerves KW - Molecular modelling KW - Pores KW - Gases KW - Data processing KW - Media (transport) KW - Waves KW - N.M.R. KW - Diffusion KW - Diffraction KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21069520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Three-dimensional+water+diffusion+in+impermeable+cylindrical+tubes%3A+theory+versus+experiments&rft.au=Avram%2C+Liat%3BOzarslan%2C+Evren%3BAssaf%2C+Yaniv%3BBar-Shir%2C+Amnon%3BCohen%2C+Yoram%3BBasser%2C+Peter+J&rft.aulast=Avram&rft.aufirst=Liat&rft.date=2008-12-01&rft.volume=21&rft.issue=8&rft.spage=888&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1277 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diffusion; Models; Pores; Diffraction; Data processing; Molecular modelling; Gases; N.M.R.; Waves; Media (transport); Nerves DO - http://dx.doi.org/10.1002/nbm.1277 ER - TY - JOUR T1 - Chronic granulomatous disease as a risk factor for autoimmune disease AN - 20736417; 8840527 AB - Chronic granulomatous disease (CGD) is characterized by recurrent infections and granuloma formation. In addition, we have observed a number of diverse autoimmune conditions in our CGD population, suggesting that patients with CGD are at an elevated risk for development of autoimmune disorders. In this report, we describe antiphospholipid syndrome, recurrent pericardial effusion, juvenile idiopathic arthritis, IgA nephropathy, cutaneous lupus erythematosus, and autoimmune pulmonary disease in the setting of CGD. The presence and type of autoimmune disease have important treatment implications for patients with CGD. JF - Journal of Allergy and Clinical Immunology AU - De Ravin, Suk See AU - Naumann, Nora AU - Cowen, Edward W AU - Friend, Julia AU - Hilligoss, Dianne AU - Np, Martha Marquesen AU - Balow, James E AU - Barron, Karyl S AU - Turner, Maria L AU - Gallin, John I AU - Malech, Harry L AD - National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md, sderavin@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1097 EP - 1103 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA, [mailto:membership@aaaai.org], [URL:http://www.aaai.org] VL - 122 IS - 6 SN - 0091-6749, 0091-6749 KW - Risk Abstracts; Immunology Abstracts KW - Cutaneous Lupus Erythematosus KW - Immunology KW - Autoimmune diseases KW - Lung diseases KW - autoimmune diseases KW - Effusion KW - Granuloma KW - Allergies KW - Arthritis KW - Risk factors KW - infection KW - Recurrent infection KW - IgA nephropathy KW - antiphospholipid syndrome KW - Chronic granulomatous disease KW - F 06925:Hypersensitivity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20736417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Chronic+granulomatous+disease+as+a+risk+factor+for+autoimmune+disease&rft.au=De+Ravin%2C+Suk+See%3BNaumann%2C+Nora%3BCowen%2C+Edward+W%3BFriend%2C+Julia%3BHilligoss%2C+Dianne%3BNp%2C+Martha+Marquesen%3BBalow%2C+James+E%3BBarron%2C+Karyl+S%3BTurner%2C+Maria+L%3BGallin%2C+John+I%3BMalech%2C+Harry+L&rft.aulast=De+Ravin&rft.aufirst=Suk&rft.date=2008-12-01&rft.volume=122&rft.issue=6&rft.spage=1097&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2008.07.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - autoimmune diseases; infection; Immunology; Allergies; Autoimmune diseases; Chronic granulomatous disease; antiphospholipid syndrome; Cutaneous Lupus Erythematosus; Granuloma; Recurrent infection; Risk factors; Effusion; IgA nephropathy; Lung diseases; Arthritis DO - http://dx.doi.org/10.1016/j.jaci.2008.07.050 ER - TY - JOUR T1 - Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 20731782; 8930912 AB - Objective: A history of diabetes has been fairly consistently related to a reduced prostate cancer risk, but previous investigations have not always addressed whether the relation with diabetes varies by prostate cancer aggressiveness or the association between diabetes and prostate cancer is modified by physical activity level and body mass, variables closely related to glucose metabolism. Methods: We prospectively examined the diabetes-prostate cancer risk relationship among 33,088 men in the screening arm of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Results: During 8.9 years follow-up, we ascertained 2,058 incident prostate cancer cases. Diabetes history was related to decreased risk of total prostate cancer (RR = 0.80, 95% CI = 0.68-0.95). The apparent protection afforded by diabetes was primarily due to the inverse relation with non-aggressive disease (i.e., the combination of low grade (Gleason sum [Lt]8) and low stage (clinical stages I or II); RR = 0.75; 95% CI = 0.62-0.91). In contrast, no association was noted between diabetes and aggressive disease (i.e., high grade or high stage (Gleason sum greater than or equal to 8 or clinical stages III or IV); RR = 1.04, 95% CI = 0.74-1.45). In further analyses, the association between diabetes and aggressive prostate cancer was suggestively positive for men who were lean (RR = 1.64, 95% CI = 0.87-3.07; BMI [Lt] 25 kg/m2) and it was positive for men who were the most physically active (RR = 1.63; 95% CI = 1.07-2.62; 3+ hours vigorous activity/week). By comparison, no relations of diabetes to aggressive prostate cancer were noted for their heavier or physically less active counterparts (p-value for tests of interaction = 0.10 and 0.03 BMI and physical activity, respectively). Conclusion: In this study, diabetes showed divergent relations with prostate cancer by tumor aggressiveness. Specifically, diabetes was inversely associated with early stage prostate cancer but it showed no relation with aggressive prostate cancer. Exploratory analyses suggested a positive association between diabetes and aggressive prostate cancer in the subgroup of men with a low BMI. JF - Cancer Causes & Control AU - Leitzmann, Michael F AU - Ahn, Jiyoung AU - Albanes, Demetrius AU - Hsing, Ann W AU - Schatzkin, Arthur AU - Chang, Shih-Chen AU - Huang, Wen-Yi AU - Weiss, Jocelyn M AU - Danforth, Kim N AU - Grubb, Robert L AU - Andriole, Gerald L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd., Bethesda, MD, 20892, USA, leitzmann@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1267 EP - 1276 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 19 IS - 10 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Historical account KW - diabetes mellitus KW - Lung KW - body mass KW - ovarian carcinoma KW - tumors KW - prostate cancer KW - aggressive behavior KW - physical activity KW - Cancer KW - Metabolism KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20731782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Diabetes+mellitus+and+prostate+cancer+risk+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Leitzmann%2C+Michael+F%3BAhn%2C+Jiyoung%3BAlbanes%2C+Demetrius%3BHsing%2C+Ann+W%3BSchatzkin%2C+Arthur%3BChang%2C+Shih-Chen%3BHuang%2C+Wen-Yi%3BWeiss%2C+Jocelyn+M%3BDanforth%2C+Kim+N%3BGrubb%2C+Robert+L%3BAndriole%2C+Gerald+L&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2008-12-01&rft.volume=19&rft.issue=10&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-008-9198-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Historical account; diabetes mellitus; body mass; Lung; ovarian carcinoma; tumors; physical activity; aggressive behavior; prostate cancer; Metabolism; Cancer DO - http://dx.doi.org/10.1007/s10552-008-9198-6 ER - TY - JOUR T1 - Cerebral sparganosis: a diagnostic challenge AN - 20656410; 9387451 AB - Cerebral sparganosis is a rare cestode larval parasitic infestation of the nervous system. We report a 28-year-old female from South India with a temporo-occipital mass lesion, which mimicked a tuberculoma on imaging. She received antituberculous therapy for 7 months. Surgical excision of the mass revealed a parasitic abscess containing larval form of Sparganum mansoni. Cerebral sparganosis can closely mimic tuberculoma or neoplastic lesions. Hence, in areas endemic for tuberculosis, such as India, it is appropriate to suggest that histological diagnosis be sought in tuberculoma mimicking lesions, especially when the lesion is not responding to treatment. JF - British Journal of Neurosurgery AU - Rengarajan, S AU - Nanjegowda, N AU - Bhat, D AU - Mahadevan, A AU - Sampath, S AU - Krishna, S AD - Departments of Neurosurgery & Neuropathology, National Institute of Mental Health and NeuroSciences, Bangalore, India Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 784 EP - 786 PB - Taylor & Francis Ltd., 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 22 IS - 6 SN - 0268-8697, 0268-8697 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Mimicry KW - Nervous system KW - Infestation KW - Mycobacterium KW - Tuberculosis KW - Abscesses KW - Neurosurgery KW - Cestoda KW - Tuberculoma KW - J 02490:Miscellaneous KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20656410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+Consumer+Research+%281986-1998%29&rft.atitle=The+Nature+and+Methodological+Implications+of+the+Cognitive+Representation+of+Products&rft.au=Johnson%2C+Michael+D%3BFornell%2C+Claes&rft.aulast=Johnson&rft.aufirst=Michael&rft.date=1987-09-01&rft.volume=14&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Research+%281986-1998%29&rft.issn=00935301&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mimicry; Infestation; Nervous system; Tuberculosis; Abscesses; Neurosurgery; Tuberculoma; Mycobacterium; Cestoda DO - http://dx.doi.org/10.1080/02688690802088073 ER - TY - JOUR T1 - Prenatal and perinatal risk factors for neuroblastoma AN - 20629417; 9355985 AB - Neuroblastoma is a rare embryonal tumor of childhood for which risk factors are not well known. Using a nested case-control design, we investigated prenatal, perinatal and neonatal risk factors in detail by linking 245 pediatric neuroblastoma cases identified in the Swedish Cancer Register diagnosed in the year 1973-1995 with the Swedish Medical Birth Register. Five living controls per case were randomly selected from the birth registry, matched by gender and age. Increased risks were associated with maternal anemia during pregnancy (odds ratio (OR) = 2.95, 95% confidence interval (CI): 1.53, 5.69), neonatal respiratory distress (OR = 3.61, 95% CI: 1.41, 9.24) and low (below or equal to 7) 1-min Apgar score (OR = 2.23, 95% CI: 1.41, 3.52). Increased risks were limited to cases diagnosed before 1 year of age. Markers of prenatal, perinatal and neonatal distress may be associated with neuroblastoma in infancy, but not with diagnoses at 1 year or above. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Bluhm, Elizabeth AU - McNeil, Dawn Elizabeth AU - Cnattingius, Sven AU - Gridley, Gloria AU - El Ghormli, Laure AU - Fraumeni Jr, Joseph F AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, elizabeth.c.bluhm@medstar.net Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2885 EP - 2890 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 12 SN - 0020-7136, 0020-7136 KW - CSA Neurosciences Abstracts; Risk Abstracts KW - Age KW - anemia KW - Pediatrics KW - Anemia KW - tumors KW - Tumors KW - Children KW - Neuroblastoma KW - Cancer KW - Pregnancy KW - prenatal experience KW - Risk factors KW - Gender KW - Neonates KW - N3 11003:Developmental neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20629417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Prenatal+and+perinatal+risk+factors+for+neuroblastoma&rft.au=Bluhm%2C+Elizabeth%3BMcNeil%2C+Dawn+Elizabeth%3BCnattingius%2C+Sven%3BGridley%2C+Gloria%3BEl+Ghormli%2C+Laure%3BFraumeni+Jr%2C+Joseph+F&rft.aulast=Bluhm&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=123&rft.issue=12&rft.spage=2885&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23847 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Pediatrics; Risk factors; Anemia; Tumors; Neonates; Children; Cancer; Neuroblastoma; Pregnancy; prenatal experience; anemia; Gender; tumors DO - http://dx.doi.org/10.1002/ijc.23847 ER - TY - JOUR T1 - Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent AN - 20626473; 9355957 AB - A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the leader peptide at the N-terminus. These results were fully confirmed by the molecular mass of rMnSOD as evaluated by ES/MS analysis (26662.7 Da) and the nucleotide sequence of the MnSOD cDNA. The role of the leader peptide in rMnSOD was investigated using a fluorescent and/or 68Gallium-labelled synthetic peptide. The labelled peptide permeated MCF-7 cells and uptake could be inhibited in the presence of an excess of oestrogen. In vivo it was taken up by the tumour, suggesting that the molecule can be used for both therapy and diagnosis. The in vitro and in vivo pharmacology tests confirmed that rMnSOD is only oncotoxic for tumour cells expressing oestrogen receptors. Pharmacokinetic studies in animals performed with 125I- and 131I-labelled proteins confirmed that, when administered systemically, rMnSOD selectively reached the tumour, where its presence was unambiguously demonstrated by scintigraphic and PET scans. PCR analysis revealed that Bax gene expression was increased and the Bcl2 gene was down regulated in MCF7 cells treated with rMnSOD, which suggests that the protein induces a pro-apoptotic mechanism. JF - International Journal of Cancer AU - Mancini, Aldo AU - Borrelli, Antonella AU - Schiattarella, Antonella AU - Aloj, Luigi AU - Aurilio, Michela AU - Morelli, Franco AU - Pica, Alessandra AU - Occhiello, Antonella AU - Lorizio, Roberto AU - Mancini, Roberto AU - Sica, Alessandro AU - Mazzarella, Lelio AU - Sica, Filomena AU - Grieco, Paolo AU - Novellino, Ettore AU - Pagnozzi, Daniela AU - Pucci, Piero AU - Rommelaere, Jean AD - Department of Molecular Biology and Biotherapy, National Cancer Institute G. Pascale Naples, Naples, Italy, aldo_mancini@tiscali.it Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2684 EP - 2695 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 11 SN - 0020-7136, 0020-7136 KW - Biotechnology and Bioengineering Abstracts KW - synthetic peptides KW - Pharmacology KW - Nucleotide sequence KW - Antitumor agents KW - Protein sorting signals KW - Pharmacokinetics KW - N-Terminus KW - Liposarcoma KW - Superoxide dismutase KW - Bax protein KW - Polymerase chain reaction KW - Estrogen receptors KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20626473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Biophysical+and+biochemical+characterization+of+a+liposarcoma-derived+recombinant+MnSOD+protein+acting+as+an+anticancer+agent&rft.au=Mancini%2C+Aldo%3BBorrelli%2C+Antonella%3BSchiattarella%2C+Antonella%3BAloj%2C+Luigi%3BAurilio%2C+Michela%3BMorelli%2C+Franco%3BPica%2C+Alessandra%3BOcchiello%2C+Antonella%3BLorizio%2C+Roberto%3BMancini%2C+Roberto%3BSica%2C+Alessandro%3BMazzarella%2C+Lelio%3BSica%2C+Filomena%3BGrieco%2C+Paolo%3BNovellino%2C+Ettore%3BPagnozzi%2C+Daniela%3BPucci%2C+Piero%3BRommelaere%2C+Jean&rft.aulast=Mancini&rft.aufirst=Aldo&rft.date=2008-12-01&rft.volume=123&rft.issue=11&rft.spage=2684&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23791 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Liposarcoma; synthetic peptides; Pharmacology; Superoxide dismutase; Nucleotide sequence; Bax protein; Polymerase chain reaction; Antitumor agents; Estrogen receptors; Pharmacokinetics; Protein sorting signals; N-Terminus DO - http://dx.doi.org/10.1002/ijc.23791 ER - TY - JOUR T1 - New complexities in helper T cell fate determination and the implications for autoimmune diseases AN - 20522840; 9198244 AB - Recently, new complexities in cell fate decision for helper T cells have emerged. One new lineage, which has come to be called Th17 cells, selectively produces proinflammatory cytokines including interleukin-17 (IL-17, A and F), IL-21, and IL-22. In conjunction with transforming growth factor beta -1 (TGF beta -1), IL-6, IL-21, and IL-23, which activate the transcription factor, signal transducer, and activator of transcription 3 (Stat3), the expression of another transcription factor, retinoic acid-related orphan receptor- Gamma t (ROR Gamma t) leads to the differentiation of Th17 cells in mice. Other cytokines including IL-2, IL-4, interferon- Gamma (IFN- Gamma ), and IL-27 inhibit Th17 differentiation. However, IL-2 acting with TGF beta -1 induces differentiation of naive CD4+ T cells to become regulatory T cells (Tregs). Th17 cells are now known to play an important role not only in the pathogenesis of inflammation and autoimmune diseases, but also host defense against extracellular bacteria. Conversely, extensive data substantiate the role of Tregs as essential in maintenance of peripheral tolerance. Selectively targeting Tregs and Th17 cells are likely to be important strategies in the treatment of inflammatory and autoimmune diseases in humans. JF - Modern Rheumatology AU - Takatori, Hiroaki AU - Kanno, Yuka AU - Chen, Zhi AU - O'Shea, John J AD - Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Room 13C120, 10 Center Drive, MSC-1930, Bethesda, MD, 20892, USA, takatorih@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 533 EP - 541 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 VL - 18 IS - 6 SN - 1439-7595, 1439-7595 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Immunoregulation KW - Interleukin 4 KW - Data processing KW - Interleukin 2 KW - Stat3 protein KW - Helper cells KW - Autoimmune diseases KW - Interleukin 21 KW - Immunological tolerance KW - Inflammation KW - Differentiation KW - CD4 antigen KW - Interleukin 22 KW - Interleukin 23 KW - Inflammatory diseases KW - Interleukin 17 KW - Transcription factors KW - Interleukin 27 KW - Lymphocytes T KW - Cell fate KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Modern+Rheumatology&rft.atitle=New+complexities+in+helper+T+cell+fate+determination+and+the+implications+for+autoimmune+diseases&rft.au=Takatori%2C+Hiroaki%3BKanno%2C+Yuka%3BChen%2C+Zhi%3BO%27Shea%2C+John+J&rft.aulast=Takatori&rft.aufirst=Hiroaki&rft.date=2008-12-01&rft.volume=18&rft.issue=6&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Modern+Rheumatology&rft.issn=14397595&rft_id=info:doi/10.1007%2Fs10165-008-0099-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Immunoregulation; Interleukin 4; Data processing; Interleukin 2; Stat3 protein; Helper cells; Autoimmune diseases; Interleukin 21; Immunological tolerance; Inflammation; Differentiation; Interleukin 22; CD4 antigen; Interleukin 23; Inflammatory diseases; Transcription factors; Interleukin 17; Interleukin 27; Lymphocytes T; Cell fate DO - http://dx.doi.org/10.1007/s10165-008-0099-z ER - TY - JOUR T1 - Modeling weight-loss maintenance to help prevent body weight regain AN - 20390575; 9070164 AB - Background: Lifestyle intervention can successfully induce weight loss in obese persons, at least temporarily. However, there currently is no way to quantitatively estimate the changes of diet or physical activity required to prevent weight regain. Such a tool would be helpful for goal-setting, because obese patients and their physicians could assess at the outset of an intervention whether long-term adherence to the calculated lifestyle change is realistic. Objective: We aimed to calculate the expected change of steady-state body weight arising from a given change in dietary energy intake and, conversely, to calculate the modification of energy intake required to maintain a particular body-weight change. Design: We developed a mathematical model using data from 8 longitudinal weight-loss studies representing 157 subjects with initial body weights ranging from 68 to 160 kg and stable weight losses between 7 and 54 kg. Results: Model calculations closely matched the change data (R super(2) = 0.83, X super(2) = 2.1, P < 0.01 for weight changes; R super(2) = 0.91, X super(2) = 0.87, P < 0.0004 for energy intake changes). Our model performed significantly better than the previous models for which X super(2) values were 10-fold those of our model. The model also accurately predicted the proportion of weight change resulting from the loss of body fat (R super(2) = 0.90). Conclusions: Our model provides realistic calculations of body-weight change and of the dietary modifications required for weight-loss maintenance. Because the model was implemented by using standard spreadsheet software, it can be widely used by physicians and weight-management professionals. JF - American Journal of Clinical Nutrition AU - Hall, K D AU - Jordan, P N AD - NIDDK/NIH, 12A South Drive, Room 4007, Bethesda, MD 20892-5621, USA, kevinh@niddk.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 VL - 88 IS - 6 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Obesity KW - Weight control KW - Diet (weight control) KW - Physicians KW - Standards KW - Exercise KW - Modeling KW - Maintenance KW - Lifestyle KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20390575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Modeling+weight-loss+maintenance+to+help+prevent+body+weight+regain&rft.au=Hall%2C+K+D%3BJordan%2C+P+N&rft.aulast=Hall&rft.aufirst=K&rft.date=2008-12-01&rft.volume=88&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Weight control; Diet (weight control); Standards; Physicians; Exercise; Maintenance; Modeling; Lifestyle ER - TY - JOUR T1 - Elevated Levels of Alanine Aminotransferase and Hepatitis A in the Context of a Pediatric Malaria Vaccine Trial in a Village in Mali AN - 20388948; 9069799 AB - A Phase 1 study of the apical membrane antigen malaria vaccine AMA1-C1/Alhydrogel was conducted in 2-3-year-old children in a village in Mali. A high frequency of elevated levels of alanine aminotransferase (ALT) caused by hepatitis A was seen, with 8 of 36 children diagnosed by specific IgM antibody over the course of the study. Hepatitis A is a common cause of asymptomatic elevations of ALT levels in children, particularly in less-developed settings. Investigators should be aware of the frequency of hepatitis A in this age group to guard against inadvertently facilitating transmission at study facilities and to properly evaluate symptomatic or asymptomatic elevations of ALT levels. JF - American Journal of Tropical Medicine and Hygiene AU - Ellis, R D AU - Dicko, A AU - Sagara, I AU - Kamate, B AU - Guindo, O AU - Niambele, M B AU - Sogoba, M AU - Doumbo, O AD - 5640 Fishers Lane, TB1, Room 1119, Rockville, MD 20852, USA, ellisru@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 VL - 79 IS - 6 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; ASFA Aquaculture Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Age KW - Human diseases KW - Mali KW - Alanine KW - Pediatrics KW - Disease control KW - Malaria KW - Children KW - Alanine transaminase KW - Antibodies KW - Antigens KW - Hepatitis A KW - Age groups KW - Vaccines KW - Hygiene KW - Immunoglobulin M KW - K 03400:Human Diseases KW - Q1 08587:Diseases of Cultured Organisms KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22400:Human Diseases KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20388948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Elevated+Levels+of+Alanine+Aminotransferase+and+Hepatitis+A+in+the+Context+of+a+Pediatric+Malaria+Vaccine+Trial+in+a+Village+in+Mali&rft.au=Ellis%2C+R+D%3BDicko%2C+A%3BSagara%2C+I%3BKamate%2C+B%3BGuindo%2C+O%3BNiambele%2C+M+B%3BSogoba%2C+M%3BDoumbo%2C+O&rft.aulast=Ellis&rft.aufirst=R&rft.date=2008-12-01&rft.volume=79&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Antibodies; Human diseases; Antigens; Alanine; Disease control; Age groups; Malaria; Vaccines; Hygiene; Age; Pediatrics; Hepatitis A; Alanine transaminase; Children; Immunoglobulin M; Mali ER - TY - JOUR T1 - Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension AN - 20387068; 9070188 AB - Background: Essential hypertension is characterized by reciprocal relations between endothelial dysfunction and insulin resistance. Cocoa flavanols stimulate production of the vasodilator nitric oxide from vascular endothelium. Objective: The objective was to test the hypothesis that consumption of cocoa may simultaneously lower blood pressure, improve endothelial dysfunction, and ameliorate insulin resistance in subjects with essential hypertension. Design: We conducted a randomized, placebo-controlled, double-blind, crossover trial of a flavanol-rich cocoa drink (150 mL twice a day, approximately 900 mg flavanols/d) in individuals with essential hypertension (n = 20). Antihypertensive medications were discontinued before study enrollment. After a 7-d cocoa-free run-in period, cocoa or flavanol-poor placebo ( approximately 28 mg flavanols/d) treatment for 2 wk was followed by a 1-wk washout and then crossover to the other treatment arm. Blood pressure was measured thrice weekly. At baseline and after each treatment period, we assessed insulin sensitivity (hyperinsulinemic-isoglycemic glucose clamp) and insulin-stimulated changes in brachial artery diameter and forearm skeletal muscle capillary recruitment (Doppler ultrasound with or without microbubble contrast). Results: Cocoa treatment for 2 wk increased insulin-stimulated changes in brachial artery diameter when compared with placebo [median percentage increase from baseline (25th-75th percentile): 8.3 (4.2-11.3) compared with 5.9 (-0.3 to 9.6); P < 0.04]. Nevertheless, cocoa treatment did not significantly reduce blood pressure or improve insulin resistance and had no significant effects on skeletal muscle capillary recruitment, circulating plasma concentrations of adipocytokines, or endothelial adhesion molecules. Conclusions: Daily consumption of flavanol-rich cocoa for 2 wk is not sufficient to reduce blood pressure or improve insulin resistance in human subjects with essential hypertension. This trial was registered at chnicaltrials.gov as NCT00099476. JF - American Journal of Clinical Nutrition AU - Muniyappa, R AU - Hall, G AU - Kolodziej, T L AU - Karne, R J AU - Crandon, S K AU - Quon, MJ AD - Diabetes Unit, NCCAM, NIH, 9 Memorial Drive, Building 9, Room 1N-105 MSC 0920, Bethesda, MD, USA, quonm@nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 VL - 88 IS - 6 SN - 0002-9165, 0002-9165 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cocoa KW - Beverages KW - Doppler effect KW - Arteries KW - Recruitment KW - Glucose KW - Clinical trials KW - Blood pressure KW - Insulin KW - Antihypertensives KW - Vasodilation KW - Endothelium KW - Skeletal muscle KW - Nitric oxide KW - Ultrasound KW - Forearm KW - Vasodilators KW - Hypertension KW - Vascular system KW - A 01360:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20387068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Cocoa+consumption+for+2+wk+enhances+insulin-mediated+vasodilatation+without+improving+blood+pressure+or+insulin+resistance+in+essential+hypertension&rft.au=Muniyappa%2C+R%3BHall%2C+G%3BKolodziej%2C+T+L%3BKarne%2C+R+J%3BCrandon%2C+S+K%3BQuon%2C+MJ&rft.aulast=Muniyappa&rft.aufirst=R&rft.date=2008-12-01&rft.volume=88&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cocoa; Beverages; Doppler effect; Arteries; Recruitment; Glucose; Clinical trials; Insulin; Blood pressure; Antihypertensives; Vasodilation; Endothelium; Nitric oxide; Skeletal muscle; Ultrasound; Forearm; Vascular system; Hypertension; Vasodilators ER - TY - JOUR T1 - Relapsing Fever Spirochetes Retain Infectivity After Prolonged in vitro Cultivation AN - 20364263; 9047646 AB - Borrelia hermsii and Borrelia burgdorferi, two closely related spirochetes, are the etiological agents of tick-borne relapsing fever and Lyme disease, respectively. Previous studies have shown the loss of infectivity of B. burgdorferi is associated with in vitro cultivation. This diminished infectivity of B. burgdorferi has occurred as early as three in vitro passages, and the loss of plasmids have been observed with these less virulent to noninfective cultures. The effects of long-term in vitro cultivation on B. hermsii have not been investigated. However, understanding the degree of genomic degradation during in vitro cultivation is important for investigating pathogenic mechanisms of spirochetes. In this study, we analyzed the effects of continuous in vitro cultivation on the genomic composition and infectivity of B. hermsii and B. turicatae. We report that all seven isolates of B. hermsii and the one isolate of B. turicatae examined retained infectivity in mice after 1 year of continuous in vitro cultivation. Furthermore, there were few apparent differences in the plasmid profiles after long-term cultivation. Two isolates of B. hermsii remained infective after high passage despite losing a portion of the 200-kb linear plasmid containing the fhbA gene encoding the factor H binding protein. Also, sequence analysis of multiple B. hermsii isolates demonstrated two types of fhbA with complete congruence with the two genomic groups of B. hermsii spirochetes. Therefore, these results suggest that relapsing fever spirochetes are genetically stable during in vitro cultivation, and the fhbA-containing segment of DNA that is lost during cultivation is not required for infection. JF - Vector Borne and Zoonotic Diseases AU - Lopez, JE AU - Schrumpf, ME AU - Raffel, S J AU - Policastro, P F AU - Porcella, S F AU - Schwan, T G AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 813 EP - 820 VL - 8 IS - 6 SN - 1530-3667, 1530-3667 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Borrelia hermsii KW - Borrelia burgdorferi KW - Relapsing fever KW - Vectors KW - Plasmids KW - Infection KW - Spirochetes KW - Infectivity KW - tick-borne diseases KW - DNA KW - genomics KW - Lyme disease KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20364263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vector+Borne+and+Zoonotic+Diseases&rft.atitle=Relapsing+Fever+Spirochetes+Retain+Infectivity+After+Prolonged+in+vitro+Cultivation&rft.au=Lopez%2C+JE%3BSchrumpf%2C+ME%3BRaffel%2C+S+J%3BPolicastro%2C+P+F%3BPorcella%2C+S+F%3BSchwan%2C+T+G&rft.aulast=Lopez&rft.aufirst=JE&rft.date=2008-12-01&rft.volume=8&rft.issue=6&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Vector+Borne+and+Zoonotic+Diseases&rft.issn=15303667&rft_id=info:doi/10.1089%2Fvbz.2008.0033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Spirochetes; Infectivity; Relapsing fever; DNA; tick-borne diseases; Vectors; genomics; Infection; Plasmids; Lyme disease; Borrelia hermsii; Borrelia burgdorferi DO - http://dx.doi.org/10.1089/vbz.2008.0033 ER - TY - JOUR T1 - Antimicrobial property of a herbal preparation containing Dalbergia sissoo and Datura stramonium with cow urine against pathogenic bacteria AN - 20349469; 9024645 AB - In this study, a herbal preparation containing Dalbergia sissoo and Datura stramoium with cow urine (DSDS), was evaluated for its antibacterial potential against pathogenic strains of gram-positive (Staphylococcus aureus and Streptococcus pneumoniae) and gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria. Antibacterial activity was compared to standard antibiotic drugs i.e. Chloramphenicol (30 mcg), Ampicillin (10 mcg), Nalidixic acid (10 mcg) and Rifampicin (30 mcg). Cow urine extract was found to be most active against both gram-positive as well as gram-negative bacteria. Clinical isolate of S. aureus showed higher sensitivity towards cow urine extract of DSDS than standard strains, and inhibited growth on most regulatory levels such as inhibition of protein, DNA, RNA and peptidoglycan synthesis. The results of the present study shows that the cow urine extract of DSDS may be used as a potent antiseptic preparation for prevention and treatment of chronic bacterial infections. JF - International Journal of Immunopathology and Pharmacology AU - Yadav, H AU - Yadav, M AU - Jain, S AU - Bhardwaj, A AU - Singh, V AU - Parkash, O AU - Marotta, F AD - Clinical Research Centre, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, yadavhariom@gmail.com Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1013 EP - 1020 VL - 21 IS - 4 SN - 0394-6320, 0394-6320 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Antibacterial activity KW - Dalbergia sissoo KW - peptidoglycans KW - Antibiotics KW - Rifampin KW - Datura stramonium KW - Antiseptics KW - Gram-negative bacteria KW - Escherichia coli KW - Nalidixic acid KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - Drugs KW - Clinical isolates KW - Chloramphenicol KW - Datura KW - Transcription KW - Ampicillin KW - Antimicrobial agents KW - Streptococcus pneumoniae KW - RNA KW - Urine KW - Chronic infection KW - DNA KW - Klebsiella pneumoniae KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20349469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Immunopathology+and+Pharmacology&rft.atitle=Antimicrobial+property+of+a+herbal+preparation+containing+Dalbergia+sissoo+and+Datura+stramonium+with+cow+urine+against+pathogenic+bacteria&rft.au=Yadav%2C+H%3BYadav%2C+M%3BJain%2C+S%3BBhardwaj%2C+A%3BSingh%2C+V%3BParkash%2C+O%3BMarotta%2C+F&rft.aulast=Yadav&rft.aufirst=H&rft.date=2008-12-01&rft.volume=21&rft.issue=4&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Immunopathology+and+Pharmacology&rft.issn=03946320&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Chloramphenicol; Antibacterial activity; Ampicillin; peptidoglycans; Transcription; Antibiotics; Antimicrobial agents; Rifampin; RNA; Urine; Antiseptics; Gram-negative bacteria; Chronic infection; Nalidixic acid; DNA; Drugs; Streptococcus pneumoniae; Datura; Datura stramonium; Dalbergia sissoo; Escherichia coli; Staphylococcus aureus; Pseudomonas aeruginosa; Klebsiella pneumoniae ER - TY - JOUR T1 - Toll-like receptor 7 is not necessary for retroviral neuropathogenesis but does contribute to virus-induced neuroinflammation AN - 20298585; 8903211 AB - Toll-like receptor 7 (TLR7) recognizes guanidine-rich single-stranded (ss) viral RNA and is an important mediator of peripheral immune responses to several ssRNA viruses. However, the role that TLR7 plays in regulating the innate immune response to ssRNA virus infections in specific organs is not as clear. This is particularly true in the central nervous system (CNS) where microglia and astrocytes are often the first cells responding to virus infection instead of dendritic cells. In the current study, we examined the mechanism by which TLR7 contributes to ssRNA virus-induced neuroinflammation using a mouse model of polytropic retrovirus infection. The authors found that TLR7 was necessary for the early production of certain cytokines and chemokines, including CCL2 and tumor necrosis factor (TNF) and was also involved in the early activation of astrocytes. However, TLR7 was not necessary for cytokine production and astrocyte activation at later stages of infection and did not alter viral pathogenesis or viral replication in the brain. This suggests that other pathogen recognition receptors may be able to compensate for the lack of TLR7 during retrovirus infection in the CNS. JF - Journal of Neurovirology AU - Lewis, S D AU - Butchi, N B AU - Khaleduzzaman, M AU - Morgan, T W AU - Du, M AU - Pourciau, S AU - Baker, D G AU - Akira, S AU - Peterson, KE AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, 903 S. 4th St., Hamilton, MT 59840, USA, petersonka@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 492 EP - 502 VL - 14 IS - 6 SN - 1355-0284, 1355-0284 KW - Virology & AIDS Abstracts; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Central nervous system KW - Chemokines KW - Monocyte chemoattractant protein 1 KW - Astrocytes KW - Replication KW - Tumor necrosis factor KW - Animal models KW - Brain KW - Neuropathogenesis KW - Pathogens KW - Infection KW - Microglia KW - Inflammation KW - Dendritic cells KW - Retrovirus KW - RNA KW - Cytokines KW - TLR7 protein KW - Toll-like receptors KW - V 22350:Immunology KW - W 30940:Products KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20298585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurovirology&rft.atitle=Toll-like+receptor+7+is+not+necessary+for+retroviral+neuropathogenesis+but+does+contribute+to+virus-induced+neuroinflammation&rft.au=Lewis%2C+S+D%3BButchi%2C+N+B%3BKhaleduzzaman%2C+M%3BMorgan%2C+T+W%3BDu%2C+M%3BPourciau%2C+S%3BBaker%2C+D+G%3BAkira%2C+S%3BPeterson%2C+KE&rft.aulast=Lewis&rft.aufirst=S&rft.date=2008-12-01&rft.volume=14&rft.issue=6&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurovirology&rft.issn=13550284&rft_id=info:doi/10.1080%2F13550280802345723 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Central nervous system; Chemokines; Monocyte chemoattractant protein 1; Astrocytes; Replication; Tumor necrosis factor; Neuropathogenesis; Brain; Animal models; Pathogens; Microglia; Infection; Inflammation; Dendritic cells; Retrovirus; RNA; Cytokines; TLR7 protein; Toll-like receptors DO - http://dx.doi.org/10.1080/13550280802345723 ER - TY - JOUR T1 - The 5' end of two redundant sRNAs is involved in the regulation of multiple targets, including their own regulator AN - 20274190; 8921080 AB - Small RNAs are widespread regulators of gene expression in numerous organisms. This study describes the mode of action of two redundant Escherichia coli sRNAs, OmrA and OmrB, that downregulate the expression of multiple targets, most of which encode outer membrane proteins. Our results show that both sRNAs directly interact with at least two of these target mRNAs, ompT and cirA, in the vicinity of the translation initiation region, consistent with control of these targets being dependent on both Hfq and RNase E. Interestingly, these interactions depend on short stretches of complementarity and involve the conserved 5' end of OmrA/B. A mutation in this region abolishes control of all OmrA/B targets tested thus far, thereby highlighting the crucial role of the OmrA/B 5' end. This allowed us, by looking for mRNA sequences complementary to the OmrA/B 5' end, to identify ompR as an additional direct target of these two sRNAs. Since the OmpR transcriptional regulator activates expression of both omrA and omrB genes, this newly identified control should result in an autoregulatory loop limiting the amount of OmrA/B sRNAs. JF - Nucleic Acids Research AU - Guillier, Maude AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, susang@helix.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 6781 EP - 6794 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - 21 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gene expression KW - outer membrane proteins KW - ribonuclease E KW - Translation initiation KW - Escherichia coli KW - Transcription KW - Mutation KW - Complementarity KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20274190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+5%27+end+of+two+redundant+sRNAs+is+involved+in+the+regulation+of+multiple+targets%2C+including+their+own+regulator&rft.au=Guillier%2C+Maude%3BGottesman%2C+Susan&rft.aulast=Guillier&rft.aufirst=Maude&rft.date=2008-12-01&rft.volume=36&rft.issue=21&rft.spage=6781&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn742 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; outer membrane proteins; Translation initiation; ribonuclease E; Transcription; Mutation; Complementarity; Escherichia coli DO - http://dx.doi.org/10.1093/nar/gkn742 ER - TY - JOUR T1 - Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world AN - 20273167; 8921090 AB - The first bacterial genome was sequenced in 1995, and the first archaeal genome in 1996. Soon after these breakthroughs, an exponential rate of genome sequencing was established, with a doubling time of approximately 20 months for bacteria and approximately 34 months for archaea. Comparative analysis of the hundreds of sequenced bacterial and dozens of archaeal genomes leads to several generalizations on the principles of genome organization and evolution. A crucial finding that enables functional characterization of the sequenced genomes and evolutionary reconstruction is that the majority of archaeal and bacterial genes have conserved orthologs in other, often, distant organisms. However, comparative genomics also shows that horizontal gene transfer (HGT) is a dominant force of prokaryotic evolution, along with the loss of genetic material resulting in genome contraction. A crucial component of the prokaryotic world is the mobilome, the enormous collection of viruses, plasmids and other selfish elements, which are in constant exchange with more stable chromosomes and serve as HGT vehicles. Thus, the prokaryotic genome space is a tightly connected, although compartmentalized, network, a novel notion that undermines the 'Tree of Life' model of evolution and requires a new conceptual framework and tools for the study of prokaryotic evolution. JF - Nucleic Acids Research AU - Koonin, Eugene V AU - Wolf, Yuri I AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA, koonin@ncbi.nlm.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 6688 EP - 6719 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - 21 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Chromosomes KW - Archaea KW - genomics KW - Evolutionary genetics KW - Plasmids KW - Evolution KW - Models KW - J 02310:Genetics & Taxonomy KW - A 01390:Forestry KW - N 14810:Methods KW - G 07770:Bacteria KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20273167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Genomics+of+bacteria+and+archaea%3A+the+emerging+dynamic+view+of+the+prokaryotic+world&rft.au=Koonin%2C+Eugene+V%3BWolf%2C+Yuri+I&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2008-12-01&rft.volume=36&rft.issue=21&rft.spage=6688&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn668 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Chromosomes; Evolutionary genetics; genomics; Plasmids; Evolution; Models; Archaea DO - http://dx.doi.org/10.1093/nar/gkn668 ER - TY - JOUR T1 - Respiratory Cancer and Inhaled Inorganic Arsenic in Copper Smelters Workers: A Linear Relationship with Cumulative Exposure that Increases with Concentration AN - 20244702; 8859425 AB - Background: Inhalation of high levels of airborne inorganic arsenic is a recognized cause of respiratory cancer. Although multiple epidemiologic studies have demonstrated this association, there have been few analyses of the mathematical relationship between cumulative arsenic exposure and risk of respiratory cancer, and no assessment as to whether and how arsenic concentration may modify this association. Objectives: The objective is an evaluation of the shape of the relationship between respiratory cancer mortality and cumulative inhaled arsenic exposure among copper smelter workers, and the modification of that relationship by arsenic concentration. Methods: We used Poisson regression methods to analyze data from a cohort of arsenic-exposed copper smelter workers under a linear-exponential model for the excess relative risk. Results: Within categories of arsenic concentration, the association between respiratory cancer and cumulative arsenic exposure was consistent with linearity. The slope of the linear relationship with cumulative exposure increased with increasing arsenic concentration category. Conclusions: Our results suggested a direct concentration effect from inhaled inorganic arsenic, whereby the excess relative risk for a fixed cumulative exposure was greater when delivered at a higher concentration and shorter duration than when delivered at a lower concentration and longer duration. JF - Environmental Health Perspectives AU - Lubin, J H AU - Moore, LE AU - Fraumeni, JF Jr AU - Cantor, K P AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 8042, Rockville, MD 20852 USA, lubinj@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1661 EP - 1665 VL - 116 IS - 12 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts; Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Risk assessment KW - Inhalation KW - Mortality KW - Arsenic KW - Data processing KW - Copper KW - Smelters KW - Cancer KW - Models KW - Workers KW - Regression analysis KW - Occupational exposure KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20244702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Respiratory+Cancer+and+Inhaled+Inorganic+Arsenic+in+Copper+Smelters+Workers%3A+A+Linear+Relationship+with+Cumulative+Exposure+that+Increases+with+Concentration&rft.au=Lubin%2C+J+H%3BMoore%2C+LE%3BFraumeni%2C+JF+Jr%3BCantor%2C+K+P&rft.aulast=Lubin&rft.aufirst=J&rft.date=2008-12-01&rft.volume=116&rft.issue=12&rft.spage=1661&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11515 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inhalation; Risk assessment; Workers; Mortality; Arsenic; Data processing; Regression analysis; Copper; Smelters; Occupational exposure; Cancer; Models DO - http://dx.doi.org/10.1289/ehp.11515 ER - TY - JOUR T1 - Of Microbes and Membranes: Pathogenic Subversion of Host Cell Processes AN - 20240864; 8853172 AB - A recent gathering of researchers at the EMBO conference "At the joint edge of Cellular Microbiology and Cell Biology" was aimed at melding ideas from both scientific fields to advance our understanding of infectious diseases at the cellular level. Work presented at this meeting highlighted how pathogens exploit host cell membrane processes to their advantage and also revealed fundamental signaling and trafficking mechanisms of eukaryotic cells. JF - Cell Host & Microbe AU - Celli, Jean AU - Knodler, Leigh A AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA, jcelli@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 514 EP - 518 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 4 IS - 6 SN - 1931-3128, 1931-3128 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cell membranes KW - Infectious diseases KW - Conferences KW - Pathogens KW - Signal transduction KW - Joints KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20240864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Host+%26+Microbe&rft.atitle=Of+Microbes+and+Membranes%3A+Pathogenic+Subversion+of+Host+Cell+Processes&rft.au=Celli%2C+Jean%3BKnodler%2C+Leigh+A&rft.aulast=Celli&rft.aufirst=Jean&rft.date=2008-12-01&rft.volume=4&rft.issue=6&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Cell+Host+%26+Microbe&rft.issn=19313128&rft_id=info:doi/10.1016%2Fj.chom.2008.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell membranes; Conferences; Infectious diseases; Pathogens; Joints; Signal transduction DO - http://dx.doi.org/10.1016/j.chom.2008.11.007 ER - TY - JOUR T1 - Sorting of Transgenic Secretory Proteins in Rhesus Macaque Parotid Glands After Adenovirus-Mediated Gene Transfer AN - 20148065; 8876185 AB - We have previously used viral vectors encoding either human growth hormone (hGH) or erythropoietin (hEPO) to study the sorting of transgenic proteins in mouse and minipig salivary glands. Whereas hGH (a regulated secretory pathway [RSP] protein) is secreted predominantly into saliva in both species, hEPO (a constitutive secretory pathway [CSP] protein) is found primarily in the bloodstream with mice, but overwhelmingly in saliva with minipigs. In view of the hEPO sorting difference, we have conducted a similar study in nonhuman primates. Specifically, we examined hGH and hEPO sorting after adenoviral (Ad) vector-mediated gene transfer to parotid glands of rhesus macaques, another large and important animal model. Two groups (n = 2 per dose group; total n = 8) of male macaques received either 10 super(10) particles per gland (low-dose group) or 10 super(11) particles per gland (high-dose group) of adenoviral (Ad) vectors encoding either hGH (AdhGH) or hEPO (Ad-hEPO) via intraoral cannulation of both parotid glands. All macaques tolerated administration of Ad vectors well, with no clinically significant changes observed in any hematological and serum chemistry parameters. In AdhGH-rreated animals, hGH was secreted exclusively into saliva. In contrast, after AdhEPO delivery, hEPO was secreted both in serum and saliva, at levels intermediate between mice and minipigs. We conclude that RSP proteins are faithfully secreted into saliva in all model species tested, whereas patterns of CSP protein secretion are variable. JF - Human Gene Therapy AU - Voutetakis, A AU - Zheng, C AU - Metzger, M AU - Cotrim, A P AU - Donahue, R E AU - Dunbar, CE AU - Baum, B J AD - Molecular Physiology and Therapeutics Branch, Building 10, Room 1N113, MSC-1190, 9000 Rockville Pike, Bethesda, MD 20892, USA, bbaum@dir.nidcr.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1401 EP - 1405 VL - 19 IS - 12 SN - 1043-0342, 1043-0342 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Growth hormone KW - Gene therapy KW - Secretion KW - Parotid gland KW - CSP protein KW - Animal models KW - Salivary gland KW - Primates KW - Expression vectors KW - Erythropoietin KW - Macaca mulatta KW - Saliva KW - Cannulation KW - W 30905:Medical Applications KW - V 22410:Animal Diseases KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20148065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Sorting+of+Transgenic+Secretory+Proteins+in+Rhesus+Macaque+Parotid+Glands+After+Adenovirus-Mediated+Gene+Transfer&rft.au=Voutetakis%2C+A%3BZheng%2C+C%3BMetzger%2C+M%3BCotrim%2C+A+P%3BDonahue%2C+R+E%3BDunbar%2C+CE%3BBaum%2C+B+J&rft.aulast=Voutetakis&rft.aufirst=A&rft.date=2008-12-01&rft.volume=19&rft.issue=12&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Expression vectors; Growth hormone; Gene therapy; Erythropoietin; Secretion; Parotid gland; Animal models; CSP protein; Saliva; Salivary gland; Cannulation; Macaca mulatta; Primates DO - http://dx.doi.org/10.1089/hum.2008.034 ER - TY - JOUR T1 - Potency and Fate Specification in CNS Stem Cell Populations In Vitro AN - 20102264; 8769926 AB - To realize the promise of stem cell biology, it is important to identify the precise time in the history of the cell when developmental potential is restricted. To achieve this goal, we developed a real-time imaging system that captures the transitions in fate, generating neurons, astrocytes, and oligodendrocytes from single CNS stem cells in vitro. In the presence of bFGF, tripotent cells normally produce specified progenitors through a bipotent intermediate cell type. Surprisingly, the tripotent state is reset at each passage. The cytokine CNTF is thought to instruct multipotent cells to an astrocytic fate. We demonstrate that CNTF both directs astrogliogenesis from tripotent cells, bypassing two of the three normal bipotent intermediates, and later promotes the expansion of specified astrocytic progenitors. These results show how discrete cell types emerge from a multipotent cell and provide a strong basis for future studies to determine the molecular basis of fate specification. JF - Cell Stem Cell AU - Ravin, Rea AU - Hoeppner, Daniel J AU - Munno, David M AU - Carmel, Liran AU - Sullivan, Jim AU - Levitt, David L AU - Miller, Jennifer L AU - Athaide, Christopher AU - Panchision, David M AU - McKay, Ronald DG AD - Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, mckay@codon.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 670 EP - 680 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 3 IS - 6 SN - 1934-5909, 1934-5909 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - STEMCELL KW - Central nervous system KW - Stem cells KW - Neurogenesis KW - Oligodendrocytes KW - Astrocytes KW - Cytokines KW - Fibroblast growth factor 2 KW - Gliogenesis KW - W 30910:Imaging KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20102264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=Potency+and+Fate+Specification+in+CNS+Stem+Cell+Populations+In+Vitro&rft.au=Ravin%2C+Rea%3BHoeppner%2C+Daniel+J%3BMunno%2C+David+M%3BCarmel%2C+Liran%3BSullivan%2C+Jim%3BLevitt%2C+David+L%3BMiller%2C+Jennifer+L%3BAthaide%2C+Christopher%3BPanchision%2C+David+M%3BMcKay%2C+Ronald+DG&rft.aulast=Ravin&rft.aufirst=Rea&rft.date=2008-12-01&rft.volume=3&rft.issue=6&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=Cell+Stem+Cell&rft.issn=19345909&rft_id=info:doi/10.1016%2Fj.stem.2008.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Central nervous system; Neurogenesis; Stem cells; Astrocytes; Oligodendrocytes; Cytokines; Fibroblast growth factor 2; Gliogenesis DO - http://dx.doi.org/10.1016/j.stem.2008.09.012 ER - TY - JOUR T1 - HER2-Specific Affibody-Conjugated Thermosensitive Liposomes (Affisomes) for Improved Delivery of Anticancer Agents AN - 20066382; 10061161 AB - Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (ZHER2:342-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characteristics and stability of the resulting nanoparticles denoted as 'Affisomes' were investigated. Thermosensitive small unilamellar vesicle (SUV) liposomes of (80-100 nm) a diameter consisting of dipalmitoyl phosphatidylcholine (DPPC, Tm 41°C) as the matrix lipid and a maleimide-conjugated pegylated phospholipid (DSPE-MaL-PEG2000) were prepared by probe sonication. Fluorescent probes were incorporated into liposomes for biophysical and/or biochemical analysis and/or triggered-release assays. Affibody was conjugated to these liposomes via its C-terminal cysteine by incubation in the presence of a reducing agent (e.g., tributylphosphine) for 16-20 hours under an argon atmosphere. Lipid-conjugated affibody molecule was visible as an 11.3-kDa band on a 4-12% Bis/Tris gel under reducing conditions. Affibody conjugation yields were ~70% at a protein-lipid ratio of 20 is a subset of g/mg, with an average number of 200 affibody molecules per Affisome. Affibody conjugation to thermosensitive liposomes did not have any significant effect on the hydrodynamic size distribution of the liposomes. Thermosensitivity of Affisomes was determined by monitoring the release of entrapped calcein (a water-soluble fluorescent probe, lambda ex/em 490/515 nm) as a function of temperature. Calcein was released from Affisomes (thermosensitive liposomes with affibody-Targeted SUV) as well as nontargeted SUV (thermosensitive liposomes without affibody) in a temperature-dependent manner, with optimal leakage (90-100%) at 41°C. In contrast, liposomes prepared from Egg phosphatidyl choline (Egg PC, Tm ~0°C) under similar conditions released only 5-10% calcein at 41°C. Affisomes, when stored at room temperature, retained > 90% entrapped calcein up to 7 days. Moreover, incubation of liposomes in phosphate-buffered saline, supplemented with 10% heat-inactivated serum (fetal bovine serum) did not result in a destabilization of liposomes. Therefore, Affisomes present promising, novel drug-delivery candidates for breast cancer targeting. JF - Journal of Liposome Research AU - Puri, Anu AU - Kramer-Marek, Gabriela AU - Campbell-Massa, Ryan AU - Yavlovich, Amichai AU - Tele, Shrikant C AU - Lee, Sang-Bong AU - Clogston, Jeffrey D AU - Patri, Anil K AU - Blumenthal, Robert AU - Capala, Jacek AD - CCR Nanobiology Program, NCI-Frederick, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 293 EP - 307 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 18 IS - 4 SN - 0898-2104, 0898-2104 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Choline KW - Hydrodynamics KW - Calcein KW - Lipids KW - Probes KW - Lecithin KW - Biochemical analysis KW - Atmosphere KW - Argon KW - Reducing agents KW - Fluorescent indicators KW - Vesicles KW - Phospholipids KW - Temperature effects KW - Physical characteristics KW - Leakage KW - Tumors KW - Antitumor agents KW - Liposomes KW - Sonication KW - Cysteine KW - Breast cancer KW - nanoparticles KW - Size distribution KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20066382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Liposome+Research&rft.atitle=HER2-Specific+Affibody-Conjugated+Thermosensitive+Liposomes+%28Affisomes%29+for+Improved+Delivery+of+Anticancer+Agents&rft.au=Puri%2C+Anu%3BKramer-Marek%2C+Gabriela%3BCampbell-Massa%2C+Ryan%3BYavlovich%2C+Amichai%3BTele%2C+Shrikant+C%3BLee%2C+Sang-Bong%3BClogston%2C+Jeffrey+D%3BPatri%2C+Anil+K%3BBlumenthal%2C+Robert%3BCapala%2C+Jacek&rft.aulast=Puri&rft.aufirst=Anu&rft.date=2008-12-01&rft.volume=18&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Journal+of+Liposome+Research&rft.issn=08982104&rft_id=info:doi/10.1080%2F08982100802457377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug delivery; Choline; Hydrodynamics; Calcein; Lipids; Lecithin; Probes; Biochemical analysis; Atmosphere; Argon; Reducing agents; Fluorescent indicators; Vesicles; Phospholipids; Temperature effects; Physical characteristics; Leakage; Tumors; Liposomes; Antitumor agents; Sonication; Cysteine; Breast cancer; nanoparticles; Size distribution DO - http://dx.doi.org/10.1080/08982100802457377 ER - TY - JOUR T1 - Opinion: [gamma]H2AX and cancer AN - 19913467; 8800222 AB - Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing [gamma]H2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using [gamma]H2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs. JF - Nature Reviews: Cancer AU - Bonner, William M AU - Redon, Christophe E AU - Dickey, Jennifer S AU - Nakamura, Asako J AU - Sedelnikova, Olga A AU - Solier, Stephanie AU - Pommier, Yves AD - William M. Bonner, Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Olga A. Sedelnikova, Stephanie Solier and Yves Pommier are at the Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., bonnerw@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 957 EP - 967 PB - Nature Publishing Group, Brunel Road Houndmills Basingstoke Hampshire RG21 6XS UK, [URL:http://www.naturesj.com/sj/index.html] VL - 8 IS - 12 SN - 1474-175X, 1474-175X KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Oncogenes & Growth Factors Abstracts KW - DNA damage KW - Phosphorylation KW - Histone H2A KW - Cancer KW - Serine KW - B 26690:General, Reviews, Book Notices KW - N 14820:DNA Metabolism & Structure KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19913467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Cancer&rft.atitle=Opinion%3A+%5Bgamma%5DH2AX+and+cancer&rft.au=Bonner%2C+William+M%3BRedon%2C+Christophe+E%3BDickey%2C+Jennifer+S%3BNakamura%2C+Asako+J%3BSedelnikova%2C+Olga+A%3BSolier%2C+Stephanie%3BPommier%2C+Yves&rft.aulast=Bonner&rft.aufirst=William&rft.date=2008-12-01&rft.volume=8&rft.issue=12&rft.spage=957&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc2523 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA damage; Phosphorylation; Histone H2A; Serine; Cancer DO - http://dx.doi.org/10.1038/nrc2523 ER - TY - JOUR T1 - The Big Bang of picorna-like virus evolution antedates the radiation of eukaryotic supergroups AN - 19911787; 8820284 AB - The recent discovery of RNA viruses in diverse unicellular eukaryotes and developments in evolutionary genomics have provided the means for addressing the origin of eukaryotic RNA viruses. The phylogenetic analyses of RNA polymerases and helicases presented in this Analysis article reveal close evolutionary relationships between RNA viruses infecting hosts from the Chromalveolate and Excavate supergroups and distinct families of picorna-like viruses of plants and animals. Thus, diversification of picorna-like viruses probably occurred in a 'Big Bang' concomitant with key events of eukaryogenesis. The origins of the conserved genes of picorna-like viruses are traced to likely ancestors including bacterial group II retroelements, the family of HtrA proteases and DNA bacteriophages. JF - Nature Reviews: Microbiology AU - Koonin, Eugene V AU - Wolf, Yuri I AU - Nagasaki, Keizo AU - Dolja, Valerian V AD - National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20894, USA., doljav@science.oregonstate.edu Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 925 EP - 939 PB - Nature Publishing Co., 345 Park Ave. S. 10th Floor New York NY 10010-1707 USA, [mailto:nature@natureny.com], [URL:http://www.nature.com/nature/] VL - 6 IS - 12 SN - 1740-1526, 1740-1526 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Phages KW - Phylogeny KW - Radiation KW - Picorna-like virus KW - DNA KW - RNA viruses KW - Proteinase KW - genomics KW - Plant viruses KW - DNA helicase KW - Evolution KW - J 02310:Genetics & Taxonomy KW - G 07800:Plants and Algae KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19911787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=The+Big+Bang+of+picorna-like+virus+evolution+antedates+the+radiation+of+eukaryotic+supergroups&rft.au=Koonin%2C+Eugene+V%3BWolf%2C+Yuri+I%3BNagasaki%2C+Keizo%3BDolja%2C+Valerian+V&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2008-12-01&rft.volume=6&rft.issue=12&rft.spage=925&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro2030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phylogeny; Phages; Radiation; DNA; Proteinase; RNA viruses; genomics; Plant viruses; DNA helicase; Evolution; Picorna-like virus DO - http://dx.doi.org/10.1038/nrmicro2030 ER - TY - JOUR T1 - A fluorescence detection platform using spatial electroluminescent excitation for measuring botulinum neurotoxin A activity AN - 19892059; 8579451 AB - Current biodetection illumination technologies (laser, LED, tungsten lamp, etc.) are based on spot illumination with additional optics required when spatial excitation is required. Herein we describe a new approach of spatial illumination based on electroluminescence (EL) semiconductor strips available in several wavelengths, greatly simplifying the biosensor design by eliminating the need for additional optics. This work combines EL excitation with charge-coupled device (CCD) based detection (EL-CCD detector) of fluorescence for developing a simple portable detector for botulinum neurotoxin A (BoTN-A) activity analysis. A Forster Resonance Energy Transfer (FRET) activity assay for BoTN-A was used to both characterize and optimize the EL-CCD detector. The system consists of two modules: (1) the detection module which houses the CCD camera and emission filters, and (2) the excitation and sample module, containing the EL strip, the excitation filter and the 9-well sample chip. The FRET activity assay used in this study utilized a FITC/DABCYL-SNAP-25 peptide substrate in which cleavage of the substrate by BoTN-A, or its light chain derivative (LcA), produced an increase in fluorescence emission. EL-CCD detector measured limits of detection (LODs) were similar to those measured using a standard fluorescent plate reader with valves between 0.625 and 1.25nM (31-62ng/ml) for LcA and 0.313nM (45ng/ml) for the full toxin, BoTN-A. As far as the authors are aware this is the first demonstration of phosphor-based EL strips being used for the spatial illumination/excitation of a surface, coupled with CCD for point of care detection. JF - Biosensors and Bioelectronics AU - Sapsford, KE AU - Sun, S AU - Francis, J AU - Sharma, S AU - Kostov, Y AU - Rasooly, A AD - Office of Science and Engineering Laboratories, FDA, Silver Spring, MD 20993, USA, rasoolya@mail.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 618 EP - 625 PB - Elsevier Advanced Technology, 660 White Plains Rd. Tarrytown NY 10591-5153 USA VL - 24 IS - 4 SN - 0956-5663, 0956-5663 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Filters KW - Biosensors KW - Light chains KW - Houses KW - Illumination KW - Cameras KW - fluorescence resonance energy transfer KW - Lasers KW - Botulinum toxin type A KW - Wavelength KW - Tungsten KW - X 24390:Radioactive Materials KW - W 30955:Biosensors KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19892059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=A+fluorescence+detection+platform+using+spatial+electroluminescent+excitation+for+measuring+botulinum+neurotoxin+A+activity&rft.au=Sapsford%2C+KE%3BSun%2C+S%3BFrancis%2C+J%3BSharma%2C+S%3BKostov%2C+Y%3BRasooly%2C+A&rft.aulast=Sapsford&rft.aufirst=KE&rft.date=2008-12-01&rft.volume=24&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2008.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biosensors; Filters; Houses; Light chains; Illumination; Cameras; fluorescence resonance energy transfer; Lasers; Wavelength; Botulinum toxin type A; Tungsten DO - http://dx.doi.org/10.1016/j.bios.2008.06.018 ER - TY - JOUR T1 - Regulation of interleukin-12-interleukin-23 production and the T-helper 17 response in humans AN - 19891780; 8783509 AB - Interleukin-12 (IL-12) and IL-23 share a common chain. Yet, their production in response to pathogens is differentially regulated, and their functions are distinct and often antithetic. IL-12 is involved in the induction or amplification of the T-helper (Th) type 1 response, whereas IL-23 has been associated with the generation of the Th17 response and IL-17 production. Mycobacterium tuberculosis and yeast zymosan induce IL-23, but in the absence of other stimuli, no IL-12 is induced in human dendritic cells (DCs). The stimulation of IL-23 by M. tuberculosis was mostly explained by the triggering of Toll-like receptor (TLR2) and the cytoplasmic receptor nucleotide oligomerization domain (NOD)-containing protein 2, whereas zymosan induces IL-23 primarily by stimulating the beta -glucan receptor dectin-1 alone or in combination with TLR2. IL-23, IL-6, transforming growth factor (TGF- beta 1), and IL-1 beta in supernatants from activated human DCs induce human naive CD4 super(+) T cells to produce IL-17. These data are consistent with various recent reports that TGF- beta is an inducer of IL-17 production both in human and in mouse cells. However, IL-1 is necessary in combination with some or all of the other cytokines to induce IL-17 production in human T cells. The ability of various stimuli to induce Th17 cells depends not only on their induction of IL-23, IL-6, and TGF- beta production in DCs but also on their ability to activate directly or indirectly the inflammasome and to induce IL-1 beta . JF - Immunological Reviews AU - Lyakh, Lyudmila AU - Trinchieri, Giorgio AU - Provezza, Lisa AU - Carra, Giuseppe AU - Gerosa, Franca AD - Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., trinchig@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 112 EP - 131 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 226 IS - 1 SN - 0105-2896, 0105-2896 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - interleukin-12 KW - interleukin-17 KW - interleukin-23 KW - T-helper 17 KW - Mycobacterium tuberculosis KW - zymosan KW - Transforming growth factor- beta 1 KW - Interleukin 6 KW - Transforming growth factor KW - Data processing KW - Helper cells KW - TLR2 protein KW - Interleukin 1 KW - Oligomerization KW - Pathogens KW - Nucleotides KW - beta -Glucan KW - Interleukin 12 KW - Dendritic cells KW - CD4 antigen KW - Interleukin 23 KW - Interleukin 17 KW - Transforming growth factor- beta KW - Lymphocytes T KW - Tuberculosis KW - Toll-like receptors KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunological+Reviews&rft.atitle=Regulation+of+interleukin-12-interleukin-23+production+and+the+T-helper+17+response+in+humans&rft.au=Lyakh%2C+Lyudmila%3BTrinchieri%2C+Giorgio%3BProvezza%2C+Lisa%3BCarra%2C+Giuseppe%3BGerosa%2C+Franca&rft.aulast=Lyakh&rft.aufirst=Lyudmila&rft.date=2008-12-01&rft.volume=226&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Immunological+Reviews&rft.issn=01052896&rft_id=info:doi/10.1111%2Fj.1600-065X.2008.00700.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Transforming growth factor- beta 1; Transforming growth factor; Data processing; Helper cells; Oligomerization; Interleukin 1; TLR2 protein; Pathogens; Nucleotides; beta -Glucan; Dendritic cells; Interleukin 12; CD4 antigen; Interleukin 23; Interleukin 17; Transforming growth factor- beta; Lymphocytes T; Tuberculosis; Toll-like receptors; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1111/j.1600-065X.2008.00700.x ER - TY - JOUR T1 - Relapsing Fever Borreliosis in Interleukin-10-Deficient Mice AN - 19799566; 8829413 AB - Relapsing fever (RF) is a spirochetal infection characterized by periods of sickness with fever at time of high bacteremia that alternate with afebrile periods of relative well being during low bacteremia. Patients with epidemic RF who are doing relatively well have extraordinarily high levels of interleukin-10 (IL-10) in the circulation. We investigated the possibility that IL-10 plays an important protective role in this infection using wild-type and IL-10-deficient mice inoculated with virulent serotype 2 of the RF spirochete Borrelia turicatae. During peak bacteremia there was increased systemic production of IL-10 that quickly resolved in the postpeak period; in contrast, IL-6 and CXCL13 production increased during the peak but remained elevated during postpeak bacteremia. IL-10 deficiency resulted in lower bacteremia, increased specific antibody production, higher production of CXCL13 and IL-6, and thrombotic and hemorrhagic complications affecting multiple organs with secondary tissue injury. Our results revealed that production of IL-10 is highly regulated during RF and plays an important protective role in the prevention of hemorrhagic and thrombotic complications at the cost of reduced pathogen control. JF - Infection and Immunity AU - Londono, Diana AU - Marques, Adriana AU - Hornung, Ronald L AU - Cadavid, Diego AD - Department of Neurology and Neuroscience and Center for Emerging Pathogens at UMDNJ-New Jersey Medical School, Newark, New Jersey 07103. Clinical Studies Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. Clinical Services Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702 Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 5508 EP - 5513 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 12 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Epidemics KW - Serotypes KW - Injuries KW - Borrelia burgdorferi KW - Relapsing fever KW - Bacteremia KW - Pathogens KW - Hemorrhage KW - Infection KW - Borrelia turicatae KW - Interleukin 10 KW - Fever KW - Spirochetes KW - Antibodies KW - CXCL13 protein KW - Borreliosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19799566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Relapsing+Fever+Borreliosis+in+Interleukin-10-Deficient+Mice&rft.au=Londono%2C+Diana%3BMarques%2C+Adriana%3BHornung%2C+Ronald+L%3BCadavid%2C+Diego&rft.aulast=Londono&rft.aufirst=Diana&rft.date=2008-12-01&rft.volume=76&rft.issue=12&rft.spage=5508&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Serotypes; Epidemics; Injuries; Relapsing fever; Bacteremia; Pathogens; Infection; Hemorrhage; Interleukin 10; Fever; Spirochetes; Antibodies; CXCL13 protein; Borreliosis; Borrelia burgdorferi; Borrelia turicatae ER - TY - JOUR T1 - Induction of type III secretion by cell-free Chlamydia trachomatis elementary bodies AN - 19796975; 8835747 AB - Chlamydiae secrete type III effector proteins at two distinct stages of their developmental cycle. Elementary bodies (EBs) secrete at least one pre-formed effector protein, Tarp, across the host plasma membrane from an extracellular location. Once internalized, a set of newly transcribed proteins are secreted to modify the inclusion membrane. In an effort to better understand the triggers for chlamydial type III secretion and develop means to identify new effectors, we investigated various inducers of T3SS in other Gram-negative bacterial systems to determine if they were able to activate chlamydial type III secretion from EBs using Tarp secretion as an indicator of activation. Chlamydial EBs are induced to secrete Tarp by exposure to FBS, BSA, or sphingolipid and cholesterol-rich liposomes (SCRLs). The induction by FBS and BSA, but not SCRL, is enhanced in the presence of the calcium-chelator, EGTA. This secretion was temperature dependent and inhibited by paraformaldehyde fixation of the EBs. JF - Microbial Pathogenesis AU - Jamison, W P AU - Hackstadt, T AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 South Fourth Street, NIAID, NIH, Hamilton, MT 59840, USA, ted_hackstadt@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 435 EP - 440 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 45 IS - 5-6 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts B: Bacteriology KW - Temperature effects KW - Plasma membranes KW - Sphingolipids KW - Secretion KW - Chlamydia trachomatis KW - Liposomes KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19796975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Induction+of+type+III+secretion+by+cell-free+Chlamydia+trachomatis+elementary+bodies&rft.au=Jamison%2C+W+P%3BHackstadt%2C+T&rft.aulast=Jamison&rft.aufirst=W&rft.date=2008-12-01&rft.volume=45&rft.issue=5-6&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2008.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; Plasma membranes; Sphingolipids; Secretion; Liposomes; Chlamydia trachomatis DO - http://dx.doi.org/10.1016/j.micpath.2008.10.002 ER - TY - JOUR T1 - GEOmetadb: powerful alternative search engine for the Gene Expression Omnibus AN - 19795725; 8817988 AB - The NCBI Gene Expression Omnibus (GEO) represents the largest public repository of microarray data. However, finding data in GEO can be challenging. We have developed GEOmetadb in an attempt to make querying the GEO metadata both easier and more powerful. All GEO metadata records as well as the relationships between them are parsed and stored in a local MySQL database. A powerful, flexible web search interface with several convenient utilities provides query capabilities not available via NCBI tools. In addition, a Bioconductor package, GEOmetadb that utilizes a SQLite export of the entire GEOmetadb database is also available, rendering the entire GEO database accessible with full power of SQL-based queries from within R.Availability: The web interface and SQLite databases available at http://gbnci.abcc.ncifcrf.gov/geo/. The Bioconductor package is available via the Bioconductor project. The corresponding MATLAB implementation is also available at the same website. JF - Bioinformatics AU - Zhu, Yuelin AU - Davis, Sean AU - Stephens, Robert AU - Meltzer, Paul S AU - Chen, Yidong AD - 1 Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 and 2 Advanced Biomedical Computing Center, National Cancer Institute-Frederick-SAIC-Frederick Inc., Frederick, MD 21702, USA Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 2798 EP - 2800 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 24 IS - 23 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Databases KW - Data processing KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19795725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=GEOmetadb%3A+powerful+alternative+search+engine+for+the+Gene+Expression+Omnibus&rft.au=Zhu%2C+Yuelin%3BDavis%2C+Sean%3BStephens%2C+Robert%3BMeltzer%2C+Paul+S%3BChen%2C+Yidong&rft.aulast=Zhu&rft.aufirst=Yuelin&rft.date=2008-12-01&rft.volume=24&rft.issue=23&rft.spage=2798&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn520 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Databases; Data processing; Bioinformatics DO - http://dx.doi.org/10.1093/bioinformatics/btn520 ER - TY - JOUR T1 - Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection AN - 19762860; 8749288 AB - Background. Recently, a hepatitis C virus (HCV) cell-culture system was developed that employed strain JFH1 (genotype 2a), and JFH1-based intra- and intergenotypic recombinants now permit functional studies of the structural genes (Core, E1, and E2), p7, and NS2 of genotypes 1-4. The goal was to adapt the system to employ genotype 5. Methods. Huh7.5 cells infected with SA13/JFH1, containing Core-NS2 of strain SA13 (genotype 5a), were monitored for Core expression and for supernatant infectivity and HCV-RNA titers. Adaptive mutations of SA13/JFH1 were identified by sequence analysis of recovered genomes and reverse-genetic studies. Receptor blockage was performed with anti-CD81 and anti-SR-BI. For neutralization experiments, SA13/JFH1 or JFH1-based viruses of other genotypes were incubated with patient sera. Results. SA13/JFH1 with NS2 and NS3 mutations yielded infectivity titers >10 super(5) TCID sub(50)/mL. Infection with SA13/JFH1 was inhibited by CD81 blocking and SR-BI blocking, respectively, and by preincubation with genotype 5a chronic-phase patient sera. Such sera had varying cross-genotype neutralization potential. However, preincubation and treatment with homologous neutralizing antibodies could not control SA13/JFH1 infection in culture. Conclusion. The SA13/JFH1 culture permits genotype 5a- specific studies of Core-NS2 function and interfering agents. The ability of HCV to spread in vivo during treatment with neutralizing antibodies was confirmed in vitro. JF - Journal of Infectious Diseases AU - Jensen, Tanja B AU - Gottwein, Judith M AU - Scheel, Troels KH AU - Hoegh, Anne M AU - Eugen-Olsen, Jesper AU - Bukh, Jens AD - Copenhagen Hepatitis C Program, Department of Infectious Diseases and Clinical Research Centre and Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, and Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, jbukh@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1756 EP - 1765 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 198 IS - 12 SN - 0022-1899, 0022-1899 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Recombinants KW - Genomes KW - Antibodies KW - Infectivity KW - Hepatitis C virus KW - Cell culture KW - Genotypes KW - CD81 antigen KW - Infection KW - Mutation KW - W 30925:Genetic Engineering KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19762860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Highly+Efficient+JFH1-Based+Cell-Culture+System+for+Hepatitis+C+Virus+Genotype+5a%3A+Failure+of+Homologous+Neutralizing-Antibody+Treatment+to+Control+Infection&rft.au=Jensen%2C+Tanja+B%3BGottwein%2C+Judith+M%3BScheel%2C+Troels+KH%3BHoegh%2C+Anne+M%3BEugen-Olsen%2C+Jesper%3BBukh%2C+Jens&rft.aulast=Jensen&rft.aufirst=Tanja&rft.date=2008-12-01&rft.volume=198&rft.issue=12&rft.spage=1756&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F593021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Recombinants; Infectivity; Antibodies; Cell culture; CD81 antigen; Genotypes; Infection; Mutation; Hepatitis C virus DO - http://dx.doi.org/10.1086/593021 ER - TY - JOUR T1 - Dynamic Behavior of Salmonella-Induced Membrane Tubules in Epithelial Cells AN - 19665045; 8823599 AB - Salmonella Typhimurium is a facultative intracellular pathogen that causes acute gastroenteritis in man. Intracellular Salmonella survive and replicate within a modified phagosome known as the Salmonella-containing vacuole (SCV). The onset of intracellular replication is accompanied by the appearance of membrane tubules, called Salmonella-induced filaments (Sifs), extending from the SCV. Sifs are enriched in late endosomal/lysosomal membrane proteins such as lysosome-associated membrane protein 1, but their formation and ability to interact with endosomal compartments are not characterized. In this study, we use live cell imaging techniques to define the dynamics of Sif formation in infected epithelial cells. At early time-points, Sifs are simple tubules extending from the surface of SCVs. These tubules are highly dynamic and exhibit bidirectional, microtubule-dependent movement. At the distal ends of individual Sif tubules, furthest from the SCV, a distinct 'leader' domain was often observed. At later times, Sifs develop into highly complex tubular networks that extend throughout the cell and appear less dynamic than nascent Sifs; however, individual tubules continue to display bidirectional dynamics. Sifs can acquire endocytic content by fusion, indicating a sustained interaction with the endocytic pathway. Together, these results show that these Salmonella-induced tubules form a highly dynamic network that involves both microtubule-dependent motility and interactions with endosomal compartments. JF - Traffic AU - Drecktrah, Dan AU - Levine-Wilkinson, Seamus AU - Dam, Tapen AU - Winfree, Seth AU - Knodler, Leigh A AU - Schroer, Trina A AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA Current address: Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA, omortimer@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2117 EP - 2129 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 12 SN - 1398-9219, 1398-9219 KW - Microbiology Abstracts B: Bacteriology KW - confocal KW - endosomes KW - lysosomes KW - microtubule KW - Salmonella-containing vacuole KW - Sifs KW - Epithelial cells KW - Replication KW - Phagosomes KW - Membrane proteins KW - Pathogens KW - Salmonella typhimurium KW - imaging KW - Motility KW - Vacuoles KW - Gastroenteritis KW - Filaments KW - Tubules KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19665045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic&rft.atitle=Dynamic+Behavior+of+Salmonella-Induced+Membrane+Tubules+in+Epithelial+Cells&rft.au=Drecktrah%2C+Dan%3BLevine-Wilkinson%2C+Seamus%3BDam%2C+Tapen%3BWinfree%2C+Seth%3BKnodler%2C+Leigh+A%3BSchroer%2C+Trina+A%3BSteele-Mortimer%2C+Olivia&rft.aulast=Drecktrah&rft.aufirst=Dan&rft.date=2008-12-01&rft.volume=9&rft.issue=12&rft.spage=2117&rft.isbn=&rft.btitle=&rft.title=Traffic&rft.issn=13989219&rft_id=info:doi/10.1111%2Fj.1600-0854.2008.00830.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Motility; Replication; Phagosomes; Vacuoles; Pathogens; Membrane proteins; Gastroenteritis; Filaments; imaging; Tubules; Salmonella typhimurium DO - http://dx.doi.org/10.1111/j.1600-0854.2008.00830.x ER - TY - JOUR T1 - The Chlamydial Inclusion Preferentially Intercepts Basolaterally Directed Sphingomyelin-Containing Exocytic Vacuoles AN - 19662851; 8823597 AB - Chlamydiae replicate intracellularly within a unique vacuole termed the inclusion. The inclusion circumvents classical endosomal/lysosomal pathways but actively intercepts a subset of Golgi-derived exocytic vesicles containing sphingomyelin (SM) and cholesterol. To further examine this interaction, we developed a polarized epithelial cell model to study vectoral trafficking of lipids and proteins to the inclusion. We examined seven epithelial cell lines for their ability to form single monolayers of polarized cells and support chlamydial development. Of these cell lines, polarized colonic mucosal C2BBe1 cells were readily infected with Chlamydia trachomatis and remained polarized throughout infection. Trafficking of (6-((N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino)hexanoyl)sphingosine) (NBD-C sub(6)-ceramide) and its metabolic derivatives, NBD-glucosylceramide (GlcCer) and NBD-SM, was analyzed. SM was retained within L2-infected cells relative to mock-infected cells, correlating with a disruption of basolateral SM trafficking. There was no net retention of GlcCer within L2-infected cells and purification of C.trachomatis elementary bodies from polarized C2BBe1 cells confirmed that bacteria retained only SM. The chlamydial inclusion thus appears to preferentially intercept basolaterally-directed SM-containing exocytic vesicles, suggesting a divergence in SM and GlcCer trafficking. The observed changes in lipid trafficking were a chlamydia-specific effect because Coxiella burnetii-infected cells revealed no changes in GlcCer or SM polarized trafficking. JF - Traffic AU - Moore, Elizabeth R AU - Fischer, Elizabeth R AU - Mead, David J AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA Microscopy Unit, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA, thackstadt@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2130 EP - 2140 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 12 SN - 1398-9219, 1398-9219 KW - Microbiology Abstracts B: Bacteriology KW - Chlamydia KW - exocytosis KW - lipid trafficking KW - pathogenesis KW - polarized cell KW - sphingomyelin KW - Epithelial cells KW - Lipids KW - Vacuoles KW - Mucosa KW - Chlamydia trachomatis KW - Vesicles KW - Cell culture KW - Cholesterol KW - Infection KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19662851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic&rft.atitle=The+Chlamydial+Inclusion+Preferentially+Intercepts+Basolaterally+Directed+Sphingomyelin-Containing+Exocytic+Vacuoles&rft.au=Moore%2C+Elizabeth+R%3BFischer%2C+Elizabeth+R%3BMead%2C+David+J%3BHackstadt%2C+Ted&rft.aulast=Moore&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=9&rft.issue=12&rft.spage=2130&rft.isbn=&rft.btitle=&rft.title=Traffic&rft.issn=13989219&rft_id=info:doi/10.1111%2Fj.1600-0854.2008.00828.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epithelial cells; sphingomyelin; Lipids; Mucosa; Vacuoles; Cell culture; Vesicles; Cholesterol; Infection; Chlamydia trachomatis DO - http://dx.doi.org/10.1111/j.1600-0854.2008.00828.x ER - TY - JOUR T1 - Time spent with smoking parents and smoking topography in adolescents AN - 19640547; 8763767 AB - Although the relationship between parental and adolescent smoking has been linked to health consequences of smoking, limited study has explored the specific association between exposure to smoking and adolescent smoking topography (the way a cigarette is smoked). As a first step in this line of enquiry, smoking topography measures were collected from 67 adolescent dependent smokers. Participants smoked one cigarette of their own brand while being monitored by a computer-based smoking-topography unit and completed questionnaires about their time spent daily with parents who smoke Pearson's correlation analysis revealed that time spent daily with parents who smoke was significantly associated with maximum puff velocity (r=0.285, p=.019), a parameter predicting later pulmonary morbidity. ANOVAs, after a median split, were consistent with correlation analyses. There was a significant group effect on puff velocity (F(2.66)=5.197, p=.008); no significant relationship was found with puff volume (F(2.66)=.617) or puff duration (F(2.66)=.776). A post hoc Tukey HSD test indicated puff velocity was higher in the "high time spent" (M=54.37, SD=12.03) than in the "low time spent" group (M=45.59, SD=9.91) and in the group with non-smoking parents (M=44.96, SD=10.17). Future research with a larger non-treatment seeking sample of adolescents aimed at preventing tobacco smoking related diseases should further examine parental influences on adolescent smoking, including potential modeling effects. JF - Addictive Behaviors AU - Collins, C C AU - Lippmann, B M AU - Lo, S J AU - Moolchan, E T AD - Teen Tobacco Addiction Treatment Research Clinic National Institute on Drug Abuse. Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA, emoolcha@intra.nida.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1594 EP - 1597 VL - 33 IS - 12 SN - 0306-4603, 0306-4603 KW - Risk Abstracts KW - Velocity KW - Morbidity KW - group effects KW - Tobacco KW - Adolescents KW - Topography KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19640547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Time+spent+with+smoking+parents+and+smoking+topography+in+adolescents&rft.au=Collins%2C+C+C%3BLippmann%2C+B+M%3BLo%2C+S+J%3BMoolchan%2C+E+T&rft.aulast=Collins&rft.aufirst=C&rft.date=2008-12-01&rft.volume=33&rft.issue=12&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2008.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Adolescents; Topography; Velocity; group effects; Tobacco; Morbidity DO - http://dx.doi.org/10.1016/j.addbeh.2008.07.003 ER - TY - JOUR T1 - A novel approach to enhance antibody sensitivity and specificity by peptide cross-linking AN - 19585899; 8766882 AB - Most current techniques employed to improve antigen-antibody signals in Western blotting and in immunohistochemistry rely on sample processing prior to staining (e.g., microwaving) or using a more robust reporter (e.g., a secondary antibody with biotin-streptavidin). We have developed and optimized a new approach intended to stabilize the complexes formed between antigens and their respective primary antibodies by cupric ions at high pH. This technique improves the affinity and lowers cross-reactivity with nonspecific bands of approximately 20% of antibodies tested (5/25). Here we report that this method can enhance antigen- antibody specificity and can improve the utility of some poorly reactive primary antibodies. JF - Analytical Biochemistry AU - Namiki, Takeshi AU - Valencia, Julio C AU - Hall, Matthew D AU - Hearing, Vincent J AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 3132, Bethesda, MD 20814, USA, hearingv@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 265 EP - 269 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 383 IS - 2 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Western blot KW - Antibody KW - Sensitivity KW - Specificity KW - Biuret reaction KW - Ions KW - Western blotting KW - Antibodies KW - Cross-reactivity KW - Antigen-antibody complexes KW - Immunohistochemistry KW - pH effects KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19585899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=A+novel+approach+to+enhance+antibody+sensitivity+and+specificity+by+peptide+cross-linking&rft.au=Namiki%2C+Takeshi%3BValencia%2C+Julio+C%3BHall%2C+Matthew+D%3BHearing%2C+Vincent+J&rft.aulast=Namiki&rft.aufirst=Takeshi&rft.date=2008-12-01&rft.volume=383&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2008.08.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Western blotting; Ions; Antibodies; Cross-reactivity; Antigen-antibody complexes; pH effects; Immunohistochemistry DO - http://dx.doi.org/10.1016/j.ab.2008.08.024 ER - TY - JOUR T1 - Autoinducer-2 is produced in saliva-fed flow conditions relevant to natural oral biofilms AN - 19572337; 8821930 AB - Aims:We evaluated the ability of a dual-species community of oral bacteria to produce the universal signalling molecule, autoinducer-2 (AI-2), in saliva-fed biofilms. Methods and Results:Streptococcus oralis 34, S. oralis 34 luxS mutant and Actinomyces naeslundii T14V were grown as single- and dual-species biofilms within sorbarods fed with 25% human saliva. AI-2 concentration in biofilm effluents was determined by the Vibrio harveyi BB170 bioluminescence assay. After homogenizing the sorbarods to release biofilm cells, cell numbers were determined by fluorometric analysis of fluorescent antibody-labelled cells. After 48h, dual-species biofilm communities of interdigitated S. oralis 34 and A. naeslundii T14V contained 3.210 super(9) cells: fivefold more than single-species biofilms. However, these 48-h dual-species biofilms exhibited the lowest concentration ratio of AI-2 to cell density. Conclusions:Oral bacteria produce AI-2 in saliva-fed biofilms. The decrease of more than 10-fold in concentration ratio seen between 1 and 48h in S. oralis 34-A. naeslundii T14V biofilms suggests that peak production of AI-2 occurs early and is followed by a very low steady-state level. Significance and Impact of the Study:High oral bacterial biofilm densities may be achieved by inter-species AI-2 signalling. We propose that low concentrations of AI-2 contribute to the establishment of oral commensal biofilm communities. JF - Journal of Applied Microbiology AU - Rickard, AH AU - Campagna AU - Kolenbrander, P E AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA, pkolenbrander@dir.nidcr.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2096 EP - 2103 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 105 IS - 6 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Actinomyces naeslundii KW - autoinducer-2 KW - cell-cell signalling KW - communication KW - dual-species biofilm KW - oral bacteria KW - Streptococcus oralis KW - LuxS protein KW - Cell number KW - Bioluminescence KW - Cell density KW - Commensals KW - Vibrio harveyi KW - Effluents KW - Biofilms KW - Saliva KW - N-octanoylhomoserine lactone KW - Signal transduction KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19572337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Autoinducer-2+is+produced+in+saliva-fed+flow+conditions+relevant+to+natural+oral+biofilms&rft.au=Rickard%2C+AH%3BCampagna%3BKolenbrander%2C+P+E&rft.aulast=Rickard&rft.aufirst=AH&rft.date=2008-12-01&rft.volume=105&rft.issue=6&rft.spage=2096&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2008.03910.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - LuxS protein; Cell number; Bioluminescence; Cell density; Commensals; Saliva; Biofilms; Effluents; N-octanoylhomoserine lactone; Signal transduction; Vibrio harveyi; Actinomyces naeslundii DO - http://dx.doi.org/10.1111/j.1365-2672.2008.03910.x ER - TY - JOUR T1 - Sepsis caused by Elizabethkingia miricola successfully treated with tigecycline and levofloxacin AN - 19571106; 8835299 AB - Elizabethkingia miricola is a Gram-negative rod that was initially isolated from condensation water of the space station Mir. This is the 1st reported case of human disease caused by this organism. JF - Diagnostic Microbiology and Infectious Disease AU - Green, O AU - Murray, P AU - Gea-Banacloche, J C AD - National Institutes of Health Clinical Center, MD 20892, USA, pmurray@cc.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 430 EP - 432 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 62 IS - 4 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Sepsis KW - tigecycline KW - Levofloxacin KW - Condensation KW - A 01490:Miscellaneous KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19571106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Sepsis+caused+by+Elizabethkingia+miricola+successfully+treated+with+tigecycline+and+levofloxacin&rft.au=Green%2C+O%3BMurray%2C+P%3BGea-Banacloche%2C+J+C&rft.aulast=Green&rft.aufirst=O&rft.date=2008-12-01&rft.volume=62&rft.issue=4&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2008.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sepsis; tigecycline; Levofloxacin; Condensation DO - http://dx.doi.org/10.1016/j.diagmicrobio.2008.07.015 ER - TY - JOUR T1 - Small membrane proteins found by comparative genomics and ribosome binding site models AN - 19568145; 8822740 AB - The correct annotation of genes encoding the smallest proteins is one of the biggest challenges of genome annotation, and perhaps more importantly, few annotated short open reading frames have been confirmed to correspond to synthesized proteins. We used sequence conservation and ribosome binding site models to predict genes encoding small proteins, defined as having 16-50 amino acids, in the intergenic regions of the Escherichia coli genome. We tested expression of these predicted as well as previously annotated genes by integrating the sequential peptide affinity tag directly upstream of the stop codon on the chromosome and assaying for synthesis using immunoblot assays. This approach confirmed that 20 previously annotated and 18 newly discovered proteins of 16-50 amino acids are synthesized. We summarize the properties of these small proteins; remarkably more than half of the proteins are predicted to be single-transmembrane proteins, nine of which we show co-fractionate with cell membranes. JF - Molecular Microbiology AU - Hemm, Matthew R AU - Paul, Brian J AU - Schneider, Thomas D AU - Storz, Gisela AU - Rudd, Kenneth E AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD20892, USA., storz@helix.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1487 EP - 1501 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 70 IS - 6 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Amino acids KW - Nucleotide sequence KW - Ribosomes KW - Membrane proteins KW - Chromosomes KW - Stop codon KW - Cell membranes KW - Reviews KW - Escherichia coli KW - Conserved sequence KW - genomics KW - Open reading frames KW - Amino acid sequence KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19568145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Small+membrane+proteins+found+by+comparative+genomics+and+ribosome+binding+site+models&rft.au=Hemm%2C+Matthew+R%3BPaul%2C+Brian+J%3BSchneider%2C+Thomas+D%3BStorz%2C+Gisela%3BRudd%2C+Kenneth+E&rft.aulast=Hemm&rft.aufirst=Matthew&rft.date=2008-12-01&rft.volume=70&rft.issue=6&rft.spage=1487&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06495.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stop codon; Chromosomes; Cell membranes; Amino acids; Nucleotide sequence; Reviews; Conserved sequence; Ribosomes; Membrane proteins; genomics; Open reading frames; Amino acid sequence; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x ER - TY - JOUR T1 - Staphylococcus aureus Elicits Marked Alterations in the Airway Proteome during Early Pneumonia AN - 19567612; 8829451 AB - Pneumonia caused by Staphylococcus aureus is a growing concern in the health care community. We hypothesized that characterization of the early innate immune response to bacteria in the lungs would provide insight into the mechanisms used by the host to protect itself from infection. An adult mouse model of Staphylococcus aureus pneumonia was utilized to define the early events in the innate immune response and to assess the changes in the airway proteome during the first 6 h of pneumonia. S. aureus actively replicated in the lungs of mice inoculated intranasally under anesthesia to cause significant morbidity and mortality. By 6 h postinoculation, the release of proinflammatory cytokines caused effective recruitment of neutrophils to the airway. Neutrophil influx, loss of alveolar architecture, and consolidated pneumonia were observed histologically 6 h postinoculation. Bronchoalveolar lavage fluids from mice inoculated with phosphate-buffered saline (PBS) or S. aureus were depleted of overabundant proteins and subjected to strong cation exchange fractionation followed by liquid chromatography and tandem mass spectrometry to identify the proteins present in the airway. No significant changes in response to PBS inoculation or 30 min following S. aureus inoculation were observed. However, a dramatic increase in extracellular proteins was observed 6 h postinoculation with S. aureus, with the increase dominated by inflammatory and coagulation proteins. The data presented here provide a comprehensive evaluation of the rapid and vigorous innate immune response mounted in the host airway during the earliest stages of S. aureus pneumonia. JF - Infection and Immunity AU - Ventura, Christy L AU - Higdon, Roger AU - Hohmann, Laura AU - Martin, Daniel AU - Kolker, Eugene AU - Liggitt, HDenny AU - Skerrett, Shawn J AU - Rubens, Craig E AD - Division of Infectious Diseases, Center for Childhood Infections and Prematurity Research. Center for Developmental Therapeutics, Seattle Children's Hospital Research Institute. BIATECH Institute. Institute for Systems Biology. Fred Hutchinson Cancer Research Center. Departments of Pediatrics. Medical Education and Biomedical Informatics. Comparative Medicine. Medicine, University of Washington School of Medicine, Seattle, Washington. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 5862 EP - 5872 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 12 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mortality KW - Data processing KW - Coagulation KW - Leukocytes (neutrophilic) KW - Animal models KW - Infection KW - Alveoli KW - Mass spectroscopy KW - Morbidity KW - Inflammation KW - Anesthesia KW - Cations KW - Bronchus KW - Liquid chromatography KW - Lung KW - Inoculation KW - Cytokines KW - Immune response KW - Staphylococcus aureus KW - Pneumonia KW - Respiratory tract KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19567612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Staphylococcus+aureus+Elicits+Marked+Alterations+in+the+Airway+Proteome+during+Early+Pneumonia&rft.au=Ventura%2C+Christy+L%3BHigdon%2C+Roger%3BHohmann%2C+Laura%3BMartin%2C+Daniel%3BKolker%2C+Eugene%3BLiggitt%2C+HDenny%3BSkerrett%2C+Shawn+J%3BRubens%2C+Craig+E&rft.aulast=Ventura&rft.aufirst=Christy&rft.date=2008-12-01&rft.volume=76&rft.issue=12&rft.spage=5862&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Coagulation; Animal models; Leukocytes (neutrophilic); Infection; Morbidity; Mass spectroscopy; Alveoli; Inflammation; Anesthesia; Bronchus; Cations; Lung; Liquid chromatography; Inoculation; Cytokines; Immune response; Pneumonia; Respiratory tract; Staphylococcus aureus ER - TY - JOUR T1 - Role of hydrogen peroxide in competition and cooperation between Streptococcus gordonii and Actinomyces naeslundii AN - 19563687; 8821450 AB - In dental plaque a-haemolytic streptococci, including Streptococcus gordonii, are considered beneficial for oral health. These organisms produce hydrogen peroxide (H sub(2)O sub(2)) at concentrations sufficient to kill many oral bacteria. Streptococci do not produce catalase yet tolerate H sub(2)O sub(2). We recently demonstrated that coaggregation with Actinomyces naeslundii stabilizes arginine biosynthesis in S. gordonii. Protein arginine residues are sensitive to oxidation by H sub(2)O sub(2). Here, the ability of A. naeslundii to protect S. gordonii against self-produced H sub(2)O sub(2) was investigated. Coaggregation with A. naeslundii enabled S. gordonii to grow in the absence of arginine, and promoted survival of S. gordonii following growth with or without added arginine. Arginine-replete S. gordonii monocultures contained 20-30kM H sub(2)O sub(2) throughout exponential growth. Actinomyces naeslundii did not produce H sub(2)O sub(2) but synthesized catalase, removed H sub(2)O sub(2) from coaggregate cultures and decreased protein oxidation in S. gordonii. On solid medium, S. gordonii inhibited growth of A. naeslundii; exogenous catalase overcame this inhibition. In coaggregate cultures, A. naeslundii cell numbers were >90% lower than in monocultures after 24h. These results indicate that coaggregation with A. naeslundii protects S. gordonii from oxidative damage. However, high cell densities of S. gordonii inhibit A. naeslundii. Therefore, H sub(2)O sub(2) may drive these organisms towards an ecologically balanced community in natural dental plaque. JF - FEMS Microbiology Ecology AU - Jakubovics, Nicholas S AU - Gill, Steven R AU - Vickerman, MMargaret AU - Kolenbrander, Paul E AD - School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK, pkolenbrander@dir.nidcr.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 637 EP - 644 PB - Elsevier Science, P.O. Box 211 VL - 66 IS - 3 SN - 0168-6496, 0168-6496 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Ecology Abstracts KW - oral streptococci KW - hydrogen peroxide KW - Actinomyces naeslundii KW - metal-catalyzed oxidation KW - Streptococcus gordonii KW - catalase KW - Cell number KW - Arginine KW - Cell density KW - Survival KW - Cell culture KW - Dental plaque KW - Catalase KW - Hydrogen peroxide KW - Oxidation KW - Competition KW - A 01450:Environmental Pollution & Waste Treatment KW - D 04040:Ecosystem and Ecology Studies KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19563687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Ecology&rft.atitle=Role+of+hydrogen+peroxide+in+competition+and+cooperation+between+Streptococcus+gordonii+and+Actinomyces+naeslundii&rft.au=Jakubovics%2C+Nicholas+S%3BGill%2C+Steven+R%3BVickerman%2C+MMargaret%3BKolenbrander%2C+Paul+E&rft.aulast=Jakubovics&rft.aufirst=Nicholas&rft.date=2008-12-01&rft.volume=66&rft.issue=3&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Ecology&rft.issn=01686496&rft_id=info:doi/10.1111%2Fj.1574-6941.2008.00585.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell number; Arginine; Hydrogen peroxide; Cell density; Oxidation; Survival; Cell culture; Dental plaque; Competition; Catalase; Streptococcus gordonii; Actinomyces naeslundii DO - http://dx.doi.org/10.1111/j.1574-6941.2008.00585.x ER - TY - JOUR T1 - Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion AN - 19366881; 8752721 AB - Acute tryptophan depletion (ATD) putatively results in a transient reduction in central serotonin transmission, and induces depressed mood in some un-medicated subjects with remitted major depressive disorder (MDD). The 5-HT transporter promoter region length polymorphism (5-HTTLPR) has been shown to influence behavioral and metabolic responses to ATD, as well as the risk for developing MDD within the context of stress. The current study investigates the relationships between 5-HTTLPR genotype, neurophysiologic response to ATD, and diagnostic phenotype (healthy control subjects versus MDD subjects differentiated by their depressive response to ATD) using super(18)FDG-PET. Un-medicated subjects with remitted MDD and healthy controls were genotyped for the long (l) and short (s) alleles of the 5-HTTLPR polymorphism and categorized into one of three genotypes. On two separate occasions, subjects received either a placebo or an amino acid mixture designed to deplete plasma tryptophan, followed by super(18)FDG-PET scanning. Depressive symptoms were rated to determine the diagnostic phenotype. Descriptive and predictive discriminant analyses were performed using brain regional metabolic data to classify according to phenotype and genotype. Overall, 79% of the cases were classified correctly by genotype, and 85% were classified correctly by phenotype. In a leave-one-out cross-validation, 72% of the subjects were classified correctly as carrying an s-allele, and 79% of the subjects were classified correctly by primary diagnosis. The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category. JF - NeuroImage AU - Nugent, Allison C AU - Neumeister, Alexander AU - Goldman, David AU - Herscovitch, Peter AU - Charney, Dennis S AU - Drevets, Wayne C AD - Section on Neuroimaging in Mood and Anxiety Disorders, NIMH, NIH, Bethesda, MD, USA, nugenta@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 764 EP - 774 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 43 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene polymorphism KW - Glucose metabolism KW - Mood KW - Promoters KW - Neurotransmission KW - Classification KW - Metabolic response KW - Tryptophan KW - Data processing KW - Amino acids KW - Depression KW - Brain KW - Stress KW - Serotonin KW - Scanning KW - Serotonin transporter KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Serotonin+transporter+genotype+and+depressive+phenotype+determination+by+discriminant+analysis+of+glucose+metabolism+under+acute+tryptophan+depletion&rft.au=Nugent%2C+Allison+C%3BNeumeister%2C+Alexander%3BGoldman%2C+David%3BHerscovitch%2C+Peter%3BCharney%2C+Dennis+S%3BDrevets%2C+Wayne+C&rft.aulast=Nugent&rft.aufirst=Allison&rft.date=2008-12-01&rft.volume=43&rft.issue=4&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.07.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tryptophan; Serotonin; Gene polymorphism; Depression; Glucose metabolism; Amino acids; Mood; Promoters; Metabolic response; Classification; Data processing; Brain; Scanning; Stress; Serotonin transporter; Neurotransmission DO - http://dx.doi.org/10.1016/j.neuroimage.2008.07.040 ER - TY - JOUR T1 - Dissociable roles of medial orbitofrontal cortex in human operant extinction learning AN - 19366660; 8752719 AB - Operant extinction, which features modification of instrumental responses to stimuli following a change in associated reinforcement, is an important form of learning for organisms in dynamic environments. Animal studies have highlighted orbital and medial prefrontal cortex and amygdala as mediators of operant extinction. Yet little is known about the neural mediators of operant extinction learning in humans. Using a novel fMRI paradigm, we report dissociable functional responses in distinct regions of medial orbitofrontal cortex (mOFC) during successful appetitive and aversive based operant extinction. During successful operant extinction, increased activity was observed in frontopolar OFC, while decreased activity was observed in caudal mOFC and rostral anterior cingulate cortex (rACC) relative to both (i) successful control trials where the reinforcement associated with the stimulus does not change; and (ii) successful acquisition trials during initial learning of the stimulus-reinforcement associations. Functional connectivity analysis demonstrated inverse connectivity between frontopolar OFC and both rACC and the amygdala. These data support animal models suggesting the importance of mOFC-amygdala interaction during operant extinction and expand our knowledge of the neural systems in humans. These findings suggest that in humans, frontopolar OFC modulates activity in caudal mOFC, rACC and amygdala during successful operant extinction learning. JF - NeuroImage AU - Finger, Elizabeth C AU - Mitchell, Derek GV AU - Jones, Matthew AU - Blair, RJR AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, Elizabeth.Finger@lhsc.on.ca Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 748 EP - 755 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 43 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Learning KW - Data processing KW - Extinction KW - Operant conditioning KW - Neural networks KW - Functional magnetic resonance imaging KW - Animal models KW - Cortex (cingulate) KW - Reinforcement KW - Amygdala KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Dissociable+roles+of+medial+orbitofrontal+cortex+in+human+operant+extinction+learning&rft.au=Finger%2C+Elizabeth+C%3BMitchell%2C+Derek+GV%3BJones%2C+Matthew%3BBlair%2C+RJR&rft.aulast=Finger&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=43&rft.issue=4&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.08.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Operant conditioning; Extinction; Learning; Cortex (prefrontal); Amygdala; Neural networks; Reinforcement; Cortex (cingulate); Data processing; Animal models; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.08.021 ER - TY - JOUR T1 - Neural interfaces at the nanoscale AN - 1328513447; 17397537 AB - Bioelectrical neural interfaces provide a means of recording the activity from the nervous system and delivering therapeutic stimulation to restore neurological function lost during disease or injury. Although neural interfaces have reached clinical utility, reducing the size of the bioelectrical interface to minimize damage to neural tissue and maximize selectivity has proven problematic. Nanotechnology may offer a means of interfacing with the nervous system with unprecedented specificity. Emergent applications of nanotechnology to neuroscience include molecular imaging, drug delivery across the BBB, scaffolds for neural regeneration and bioelectrical interfaces. In particular, carbon nanotubes offer the promises of material stability and low electrical impedance at physical dimensions that could have a significant impact on the future on neural interfaces. The purpose of this review is to present recent advances in carbon nanotube-based bioelectrical interfaces for the nervous system and discuss research challenges and opportunities. JF - Nanomedicine AU - Pancrazio, Joseph J AD - National Institutes of Health, NINDS, 6001 Executive Boulevard, NSC/2205, Rockville, MD 20892, USA., pancrazj@ninds.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 823 EP - 830 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 3 IS - 6 SN - 1743-5889, 1743-5889 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Injuries KW - Blood-brain barrier KW - Computer applications KW - Electrical impedance KW - Recovery of function KW - scaffolds KW - Nervous system KW - Carbon KW - Implants KW - Regeneration KW - nanotubes KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1328513447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Neural+interfaces+at+the+nanoscale&rft.au=Pancrazio%2C+Joseph+J&rft.aulast=Pancrazio&rft.aufirst=Joseph&rft.date=2008-12-01&rft.volume=3&rft.issue=6&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2F17435889.3.6.823 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Number of references - 70 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Drug delivery; Injuries; Blood-brain barrier; Computer applications; Recovery of function; Electrical impedance; scaffolds; Nervous system; Carbon; Implants; Regeneration; nanotubes; nanotechnology DO - http://dx.doi.org/10.2217/17435889.3.6.823 ER - TY - JOUR T1 - Mitochondrial DNA haplogroups influence AIDS progression. AN - 69773188; 19005266 AB - Mitochondrial function plays a role in both AIDS progression and HAART toxicity; therefore, we sought to determine whether mitochondrial DNA variation revealed novel AIDS restriction genes, particularly as mitochondrial DNA single-nucleotide polymorphisms are known to influence regulation of oxidative phosphorylation, reactive oxygen species production, and apoptosis. This is a retrospective cohort study. We performed an association study of mitochondrial DNA haplogroups among 1833 European American HIV-1 patients from five US cohorts: the Multicenter AIDS Cohort Study, the San Francisco City Clinic Study, Hemophilia Growth and Development Study, the Multicenter Hemophilia Cohort Study, and the AIDS Linked to Intravenous Experiences cohort to determine whether the mitochondrial DNA haplogroup correlated with AIDS progression rate. Mitochondrial DNA haplogroups J and U5a were elevated among HIV-1 infected people who display accelerated progression to AIDS and death. Haplogroups Uk, H3, and IWX appeared to be highly protective against AIDS progression. The associations found in our study appear to support a functional explanation by which mitochondrial DNA variation among haplogroups, influencing ATP production, reactive oxygen species generation, and apoptosis, is correlated to AIDS disease progression; however, repeating these results in cohorts with different ethnic backgrounds would be informative. These data suggest that mitochondrial genes are important indicators of AIDS disease progression in HIV-1 infected persons. JF - AIDS (London, England) AU - Hendrickson, Sher L AU - Hutcheson, Holli B AU - Ruiz-Pesini, Eduardo AU - Poole, Jason C AU - Lautenberger, James AU - Sezgin, Efe AU - Kingsley, Lawrence AU - Goedert, James J AU - Vlahov, David AU - Donfield, Sharyne AU - Wallace, Douglas C AU - O'Brien, Stephen J AD - Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702-1201, USA. hendricksons@mail.nih.gov Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 SP - 2429 EP - 2439 VL - 22 IS - 18 KW - DNA, Mitochondrial KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Polymorphism, Single Nucleotide KW - Humans KW - Cohort Studies KW - Adult KW - Disease Progression KW - Antiretroviral Therapy, Highly Active KW - Middle Aged KW - Male KW - Female KW - HIV-1 -- genetics KW - Haplotypes -- genetics KW - HIV-1 -- immunology KW - HIV Infections -- immunology KW - HIV Infections -- genetics KW - HIV Infections -- mortality KW - Haplotypes -- immunology KW - DNA, Mitochondrial -- immunology KW - DNA, Mitochondrial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69773188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Mitochondrial+DNA+haplogroups+influence+AIDS+progression.&rft.au=Hendrickson%2C+Sher+L%3BHutcheson%2C+Holli+B%3BRuiz-Pesini%2C+Eduardo%3BPoole%2C+Jason+C%3BLautenberger%2C+James%3BSezgin%2C+Efe%3BKingsley%2C+Lawrence%3BGoedert%2C+James+J%3BVlahov%2C+David%3BDonfield%2C+Sharyne%3BWallace%2C+Douglas+C%3BO%27Brien%2C+Stephen+J&rft.aulast=Hendrickson&rft.aufirst=Sher&rft.date=2008-11-30&rft.volume=22&rft.issue=18&rft.spage=2429&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=1473-5571&rft_id=info:doi/10.1097%2FQAD.0b013e32831940bb LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):171-6 [12509511] Vaccine. 2008 Jun 6;26(24):2951-65 [18325640] Am J Hum Genet. 2003 Apr;72(4):804-11 [12618962] Exp Gerontol. 2003 Apr;38(4):397-405 [12670626] J Med Virol. 2003 Aug;70(4):497-505 [12794710] Science. 2004 Jan 9;303(5655):223-6 [14716012] Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R9-19 [14764621] Ann N Y Acad Sci. 2003 Dec;1010:19-28 [15033690] Nat Genet. 2004 Jun;36(6):565-74 [15167933] Clin Infect Dis. 2004 Sep 1;39(5):710-6 [15356787] MMWR Morb Mortal Wkly Rep. 1987 Dec 25;36 Suppl 7:1S-20S [2826984] N Engl J Med. 1989 Oct 26;321(17):1141-8 [2477702] NIDA Res Monogr. 1991;109:75-100 [1661376] J Acquir Immune Defic Syndr. 1992;5(5):490-6 [1560346] MMWR Recomm Rep. 1992 Dec 18;41(RR-17):1-19 [1361652] Am J Pediatr Hematol Oncol. 1993 May;15(2):208-18 [8498644] FEBS Lett. 1993 Sep 27;331(1-2):182-6 [8104823] J Bioenerg Biomembr. 1994 Jun;26(3):241-50 [8077179] Am J Hum Genet. 1994 Oct;55(4):760-76 [7942855] AIDS. 1994 Aug;8(8):1123-8 [7986410] Antibiot Chemother (1971). 1996;48:4-12 [8726500] Am J Hum Genet. 1997 May;60(5):1107-21 [9150158] Science. 1997 Aug 15;277(5328):959-65 [9252328] Science. 1998 Jan 16;279(5349):389-93 [9430590] FEBS Lett. 1998 Jul 31;432(1-2):17-20 [9710242] AIDS. 1998 Oct 1;12(14):1735-44 [9792373] Cell Signal. 1999 Jan;11(1):1-14 [10206339] Lancet. 1999 Sep 25;354(9184):1112-5 [10509516] Eur J Hum Genet. 2004 Dec;12(12):1080-2 [15470367] J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1477-88 [15602126] J Exp Med. 2000 Jan 3;191(1):33-46 [10620603] Eur J Hum Genet. 2005 Aug;13(8):965-9 [15886711] AIDS. 2005 Sep 2;19(13):1341-9 [16103764] Cancer Res. 2005 Sep 1;65(17):8028-33 [16140977] Antivir Ther. 2005;10 Suppl 2:M13-27 [16152703] Nat Genet. 2005 Nov;37(11):1243-6 [16228001] Annu Rev Genet. 2005;39:359-407 [16285865] Lancet. 2005 Dec 17;366(9503):2118-21 [16360789] Am J Hum Genet. 2000 Sep;67(3):682-96 [10936107] Clin Exp Immunol. 2000 Dec;122(3):364-73 [11122242] Annu Rev Genet. 2000;34:563-591 [11092839] FASEB J. 2001 Jan;15(1):5-6 [11099484] Nat Cell Biol. 2001 Nov;3(11):E255-63 [11715037] Free Radic Biol Med. 2002 Mar 1;32(5):414-20 [11864781] Free Radic Biol Med. 2002 Jul 15;33(2):192-200 [12106815] Hum Genet. 2003 Jan;112(1):29-33 [12483296] EMBO J. 2002 Dec 16;21(24):6801-10 [12486001] Gene. 2006 Mar 1;368:21-7 [16326035] AIDS. 2006 Mar 21;20(5):675-84 [16514297] Am J Hum Genet. 2006 Apr;78(4):713-20 [16532401] J Virol. 2006 Jul;80(14):6757-63 [16809281] Nat Genet. 2006 Aug;38(8):904-9 [16862161] Int J Biochem Cell Biol. 2006;38(10):1647-53 [16766221] Nature. 2006 Oct 19;443(7113):787-95 [17051205] Hum Mutat. 2006 Nov;27(11):1072-81 [16947981] Nucleic Acids Res. 2007 Jan;35(Database issue):D823-8 [17178747] Physiol Rev. 2007 Jan;87(1):99-163 [17237344] Environ Mol Mutagen. 2007 Apr-May;48(3-4):166-72 [16758472] PLoS Genet. 2008 Jan;4(1):e236 [18208327] Annu Rev Med. 2003;54:535-51 [12525683] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/QAD.0b013e32831940bb ER - TY - CPAPER T1 - Construction of an Abdominal Probabilistic Atlas and Its Application in Automated Liver Segmentation T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41853700; 5062060 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Linguraru, Marius AU - Li, Zhixi AU - Summers, Ronald Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Liver KW - Segmentation KW - Atlases KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Construction+of+an+Abdominal+Probabilistic+Atlas+and+Its+Application+in+Automated+Liver+Segmentation&rft.au=Linguraru%2C+Marius%3BLi%2C+Zhixi%3BSummers%2C+Ronald&rft.aulast=Linguraru&rft.aufirst=Marius&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of Patient Specific CT Dosimetry Using Treatment Planning System T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41851966; 5061897 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Cheng, Jason AU - Xie, Huchen AU - Fearon, Thomas AU - Li, Guang AU - Ning, Holly AU - Arora, Barbara Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Dosimetry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Study+of+Patient+Specific+CT+Dosimetry+Using+Treatment+Planning+System&rft.au=Cheng%2C+Jason%3BXie%2C+Huchen%3BFearon%2C+Thomas%3BLi%2C+Guang%3BNing%2C+Holly%3BArora%2C+Barbara&rft.aulast=Cheng&rft.aufirst=Jason&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 3T MR Imaging of the Prostate Gland: What the Urologist Needs to Know T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41839486; 5064142 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Turkbey, Baris AU - Ravizzini, Gregory AU - Mani, Haresh AU - Bernardo, Marcelino AU - Pinto, Peter AU - Choyke, Peter Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Magnetic resonance imaging KW - Prostate KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=3T+MR+Imaging+of+the+Prostate+Gland%3A+What+the+Urologist+Needs+to+Know&rft.au=Turkbey%2C+Baris%3BRavizzini%2C+Gregory%3BMani%2C+Haresh%3BBernardo%2C+Marcelino%3BPinto%2C+Peter%3BChoyke%2C+Peter&rft.aulast=Turkbey&rft.aufirst=Baris&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Contrast-enhanced MR Imaging: A Useful Tool for Cancer Diagnosis and Monitoring of Angiogenic Inhibitor Therapy T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41831869; 5063441 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Turkbey, Baris AU - Thomasson, David AU - Bernardo, Marcelino AU - Pang, Yuxi AU - Choyke, Peter Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Cancer KW - Magnetic resonance imaging KW - Angiogenesis KW - Therapy KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41831869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Dynamic+Contrast-enhanced+MR+Imaging%3A+A+Useful+Tool+for+Cancer+Diagnosis+and+Monitoring+of+Angiogenic+Inhibitor+Therapy&rft.au=Turkbey%2C+Baris%3BThomasson%2C+David%3BBernardo%2C+Marcelino%3BPang%2C+Yuxi%3BChoyke%2C+Peter&rft.aulast=Turkbey&rft.aufirst=Baris&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optical/CT Colon Cancer Detection Probes T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41830188; 5062384 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Roney, Celeste AU - Xie, Jianwu AU - Xu, Biying AU - Griffiths, Gary AU - Summers, Ronald Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Colon cancer KW - Probes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41830188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Optical%2FCT+Colon+Cancer+Detection+Probes&rft.au=Roney%2C+Celeste%3BXie%2C+Jianwu%3BXu%2C+Biying%3BGriffiths%2C+Gary%3BSummers%2C+Ronald&rft.aulast=Roney&rft.aufirst=Celeste&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coronary Veins Imaging Utilizing Free-Breathing Whole-Heart 3D Cardiac Magnetic Resonance Imaging (MRI) at 3.0 Tesla: A Comparative Study with Multidetector Computed Tomography (MDCT) T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41801354; 5062141 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Elagha, Abdalla AU - Pettigrew, Roderic AU - Gharib, Ahmed Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Computed tomography KW - Comparative studies KW - Magnetic resonance imaging KW - Heart KW - Veins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41801354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Coronary+Veins+Imaging+Utilizing+Free-Breathing+Whole-Heart+3D+Cardiac+Magnetic+Resonance+Imaging+%28MRI%29+at+3.0+Tesla%3A+A+Comparative+Study+with+Multidetector+Computed+Tomography+%28MDCT%29&rft.au=Elagha%2C+Abdalla%3BPettigrew%2C+Roderic%3BGharib%2C+Ahmed&rft.aulast=Elagha&rft.aufirst=Abdalla&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computer-aided Detection of Polyps at Non-cathartic CTC Using Heterogeneous Stool Removal: FROC Study T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41791324; 5061718 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Linguraru, Marius AU - Zhao, Shan AU - Van Uitert, Robert AU - Fletcher, Joel AU - Johnson, Daniel AU - Summers, Ronald Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Polyps KW - Feces KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41791324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Computer-aided+Detection+of+Polyps+at+Non-cathartic+CTC+Using+Heterogeneous+Stool+Removal%3A+FROC+Study&rft.au=Linguraru%2C+Marius%3BZhao%2C+Shan%3BVan+Uitert%2C+Robert%3BFletcher%2C+Joel%3BJohnson%2C+Daniel%3BSummers%2C+Ronald&rft.aulast=Linguraru&rft.aufirst=Marius&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bilateral Laparoscopic Adrenalectomies: Our Experience T2 - 26th World Congress of Endourology (WCE 26) AN - 41744549; 5001891 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Papalia, Rocco AU - Guaglianone, Salvatore AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Adrenalectomy KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41744549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Bilateral+Laparoscopic+Adrenalectomies%3A+Our+Experience&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BPapalia%2C+Rocco%3BGuaglianone%2C+Salvatore%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20I).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic treatment of multiple diseases in a single operating session T2 - 26th World Congress of Endourology (WCE 26) AN - 41735777; 5003225 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Papalia, Rocco AU - Leonardo, Costantino AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Laparoscopy KW - Disease control KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41735777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Laparoscopic+treatment+of+multiple+diseases+in+a+single+operating+session&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20II).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic partial nephrectomy following superselective arterial embolization T2 - 26th World Congress of Endourology (WCE 26) AN - 41712319; 5003070 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Papalia, Rocco AU - Leonardo, Costantino AU - Guaglianone, Salvatore AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Nephrectomy KW - Embolization KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41712319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Laparoscopic+partial+nephrectomy+following+superselective+arterial+embolization&rft.au=Simone%2C+Giuseppe%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BGuaglianone%2C+Salvatore%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20II).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surgical Steps of Laparoscopic Heminephroureterectomy for a Complete Duplication of the Left Collecting System T2 - 26th World Congress of Endourology (WCE 26) AN - 41710905; 5002298 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Papalia, Rocco AU - Leonardo, Costantino AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Surgery KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41710905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Surgical+Steps+of+Laparoscopic+Heminephroureterectomy+for+a+Complete+Duplication+of+the+Left+Collecting+System&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20I).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Upper Pole Laparoscopic Resection Following Superselective Arterial Embolization T2 - 26th World Congress of Endourology (WCE 26) AN - 41701414; 5002403 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Papalia, Rocco AU - Leonardo, Costantino AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Embolization KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41701414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Upper+Pole+Laparoscopic+Resection+Following+Superselective+Arterial+Embolization&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20I).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic Nephrectomy with Enseal Device: First Experience T2 - 26th World Congress of Endourology (WCE 26) AN - 41701241; 5002367 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Guaglianone, Salvatore AU - Papalia, Rocco AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Nephrectomy KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41701241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Laparoscopic+Nephrectomy+with+Enseal+Device%3A+First+Experience&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BGuaglianone%2C+Salvatore%3BPapalia%2C+Rocco%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20I).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic bilateral adrenalectomy in a patient previously undergone radical cystectomy and ileal conduit T2 - 26th World Congress of Endourology (WCE 26) AN - 41685143; 5002504 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Papalia, Rocco AU - Leonardo, Costantino AU - Loreto, Andrea AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Radicals KW - Adrenalectomy KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41685143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Laparoscopic+bilateral+adrenalectomy+in+a+patient+previously+undergone+radical+cystectomy+and+ileal+conduit&rft.au=Simone%2C+Giuseppe%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BLoreto%2C+Andrea%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20II).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. AN - 69827208; 18801729 AB - Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is a putative tumor suppressor whose expression can be increased by drug treatment. Glioblastoma is the most common central nervous system tumor, is associated with high morbidity and mortality, and responds poorly to surgical, chemical, and radiation therapy. The histone deacetylase inhibitors are under current consideration as therapeutic agents in treating glioblastoma. We investigated whether trichostatin A (TSA) would alter the expression of NAG-1 in glioblastoma cells. The DNA demethylating agent 5-aza-dC did not increase NAG-1 expression, but TSA up-regulated NAG-1 expression and acted synergistically with 5-aza-dC to induce NAG-1 expression. TSA indirectly increases NAG-1 promoter activity and increases NAG-1 mRNA and protein expression in the T98G human glioblastoma cell line. TSA also increases the expression of transcription factors Sp-1 and Egr-1. Small interfering RNA experiments link NAG-1 expression to apoptosis induced by TSA. Reporter gene assays, specific inhibition by small interfering RNA transfections, and chromatin immunoprecipitation assays indicate that Egr-1 and Sp-1 mediate TSA-induced NAG-1 expression. TSA also increases the stability of NAG-1 mRNA. TSA-induced NAG-1 expression involves multiple mechanisms at the transcriptional and post-transcriptional levels. JF - The Journal of biological chemistry AU - Yoshioka, Hiroki AU - Kamitani, Hideki AU - Watanabe, Takashi AU - Eling, Thomas E AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/11/28/ PY - 2008 DA - 2008 Nov 28 SP - 33129 EP - 33137 VL - 283 IS - 48 SN - 0021-9258, 0021-9258 KW - EGR1 protein, human KW - 0 KW - Early Growth Response Protein 1 KW - Enzyme Inhibitors KW - GDF15 protein, human KW - Growth Differentiation Factor 15 KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - Neoplasm Proteins KW - RNA, Messenger KW - RNA, Neoplasm KW - RNA, Small Interfering KW - Sp1 Transcription Factor KW - trichostatin A KW - 3X2S926L3Z KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - RNA, Neoplasm -- biosynthesis KW - Azacitidine -- pharmacology KW - Early Growth Response Protein 1 -- metabolism KW - Humans KW - Azacitidine -- analogs & derivatives KW - Up-Regulation -- drug effects KW - Sp1 Transcription Factor -- metabolism KW - RNA, Small Interfering -- pharmacology KW - Cell Line, Tumor KW - RNA, Messenger -- biosynthesis KW - Neoplasm Proteins -- biosynthesis KW - Neoplasm Proteins -- antagonists & inhibitors KW - Growth Differentiation Factor 15 -- antagonists & inhibitors KW - Glioblastoma -- metabolism KW - Growth Differentiation Factor 15 -- biosynthesis KW - Enzyme Inhibitors -- pharmacology KW - Hydroxamic Acids -- pharmacology KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69827208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Nonsteroidal+anti-inflammatory+drug-activated+gene+%28NAG-1%2FGDF15%29+expression+is+increased+by+the+histone+deacetylase+inhibitor+trichostatin+A.&rft.au=Yoshioka%2C+Hiroki%3BKamitani%2C+Hideki%3BWatanabe%2C+Takashi%3BEling%2C+Thomas+E&rft.aulast=Yoshioka&rft.aufirst=Hiroki&rft.date=2008-11-28&rft.volume=283&rft.issue=48&rft.spage=33129&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M805248200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-29 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Dec 1;20(23):8597-603 [11102463] Mol Cancer. 2007;6:36 [17547775] J Comp Neurol. 2001 Oct 8;439(1):32-45 [11579380] J Biol Chem. 2001 Nov 9;276(45):42084-90 [11551946] J Clin Oncol. 2002 Mar 1;20(5):1375-82 [11870182] Carcinogenesis. 2002 Mar;23(3):425-34 [11895857] J Biol Chem. 2002 May 10;277(19):16823-30 [11877441] J Pharmacol Exp Ther. 2002 Jun;301(3):1126-31 [12023546] Biochem Biophys Res Commun. 2002 Jul 5;295(1):187-92 [12083788] Circ Res. 2002 Nov 1;91(9):837-44 [12411399] Br J Cancer. 2002 Oct 21;87(9):1042-6 [12434298] Mol Pharmacol. 2003 Mar;63(3):557-64 [12606762] Nucleic Acids Res. 2003 Mar 15;31(6):1693-703 [12626711] Int J Cancer. 2003 Jul 20;105(6):747-53 [12767058] Oncogene. 2003 Sep 4;22(38):6023-31 [12955081] J Biol Chem. 2004 Feb 20;279(8):6883-92 [14662774] Carcinogenesis. 2004 Oct;25(10):1813-20 [15142888] J Biol Chem. 1979 Mar 10;254(5):1716-23 [762168] J Biol Chem. 1993 Oct 25;268(30):22429-35 [8226751] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5705-8 [8650156] Nature. 1997 Sep 25;389(6649):349-52 [9311776] Cell. 1998 Feb 20;92(4):463-73 [9491888] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3356-61 [9520369] Exp Cell Res. 1998 May 25;241(1):126-33 [9633520] Nat Genet. 1999 Jan;21(1):103-7 [9916800] Curr Opin Genet Dev. 1999 Feb;9(1):40-8 [10072350] Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4592-7 [10200307] Oncogene. 1999 Apr 15;18(15):2461-70 [10229197] Mol Cell Biol. 1999 Aug;19(8):5504-11 [10409740] Mol Pharmacol. 2005 Feb;67(2):356-64 [15509713] Biochem Biophys Res Commun. 2005 Mar 4;328(1):63-9 [15670751] Acta Neuropathol. 2005 Jan;109(1):93-108 [15685439] Prostate. 2008 Feb 1;68(2):210-22 [18092350] Br J Pharmacol. 2008 Feb;153(4):657-68 [18059320] J Cell Mol Med. 2008 Apr;12(2):607-21 [18419600] Breast Cancer Res Treat. 2008 Sep;111(1):15-25 [17891453] Cancer Lett. 2008 Oct 18;270(1):30-9 [18550273] J Biol Chem. 2005 Sep 23;280(38):32569-77 [15994313] Mol Cancer Ther. 2005 Oct;4(10):1551-8 [16227405] Prog Lipid Res. 2006 Jan;45(1):1-16 [16337272] Mol Cancer Ther. 2006 May;5(5):1352-61 [16731769] J Pharmacol Exp Ther. 2006 Aug;318(2):899-906 [16714403] Gastroenterology. 2006 Nov;131(5):1553-60 [17101328] J Biochem Mol Biol. 2006 Nov 30;39(6):649-55 [17129398] J Biol Chem. 2007 Feb 16;282(7):4765-71 [17121856] Cancer. 2007 Apr 15;109(8):1676-88 [17330857] J Biol Chem. 2001 Sep 7;276(36):33384-92 [11445565] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M805248200 ER - TY - JOUR T1 - Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site. AN - 69826085; 18805795 AB - Pigment epithelium-derived factor (PEDF) is a multifunctional serpin with antitumorigenic, antimetastatic, and differentiating activities. PEDF is found within tissues rich in the glycosaminoglycan hyaluronan (HA), and its amino acid sequence contains putative HA-binding motifs. We show that PEDF coprecipitation with glycosaminoglycans in media conditioned by human retinoblastoma Y-79 cells decreased after pretreatments with hyaluronidase, implying an association between HA and PEDF. Direct binding of human recombinant PEDF to highly purified HA was demonstrated by coprecipitation in the presence of cetylpyridinium chloride. Binding of PEDF to HA was concentration-dependent and saturable. The PEDF-HA interactions were sensitive to increasing NaCl concentrations, indicating an ionic nature of these interactions and having affinity higher than PEDF-heparin. Competition assays showed that PEDF can bind heparin and HA simultaneously. PEDF chemically modified with fluorescein retained the capacity for interacting with HA but lacked heparin affinity, suggesting one or more distinct HA-binding regions on PEDF. The HA-binding region was examined by site-directed mutagenesis. Single-point and cumulative alterations at basic residues within the putative HA-binding motif K189A/K191A/R194A/K197A drastically reduced the HA-binding activity without affecting heparin- or collagen I binding of PEDF. Cumulative alterations at sites critical for heparin binding (K146A/K147A/R149A) decreased HA affinity but not collagen I binding. Thus these clusters of basic residues (BXBXXBXXB and BX3AB2XB motifs) in PEDF are functional regions for binding HA. In the spatial PEDF structure they are located in distinct areas away from the collagen-binding site. The HA-binding activity of PEDF may contribute to deposition in the extracellular matrix and to its reported antitumor/antimetastatic effects. JF - The Journal of biological chemistry AU - Becerra, S Patricia AU - Perez-Mediavilla, L Alberto AU - Weldon, John E AU - Locatelli-Hoops, Silvia AU - Senanayake, Preenie AU - Notari, Luigi AU - Notario, Vicente AU - Hollyfield, Joe G AD - NEI, National Institutes of Health, Bethesda, Maryland 20892, USA. becerrap@nei.nih.gov Y1 - 2008/11/28/ PY - 2008 DA - 2008 Nov 28 SP - 33310 EP - 33320 VL - 283 IS - 48 SN - 0021-9258, 0021-9258 KW - Eye Proteins KW - 0 KW - Nerve Growth Factors KW - Serpins KW - pigment epithelium-derived factor KW - Hyaluronic Acid KW - 9004-61-9 KW - Heparin KW - 9005-49-6 KW - Index Medicus KW - Rats KW - Mutagenesis, Site-Directed KW - Protein Binding -- physiology KW - Animals KW - Amino Acid Motifs -- physiology KW - Humans KW - Organ Specificity -- physiology KW - Heparin -- metabolism KW - Heparin -- chemistry KW - Cell Line, Tumor KW - Amino Acid Substitution KW - Cricetinae KW - Nerve Growth Factors -- metabolism KW - Extracellular Matrix -- metabolism KW - Peptide Mapping KW - Eye Proteins -- chemistry KW - Eye Proteins -- metabolism KW - Serpins -- chemistry KW - Hyaluronic Acid -- chemistry KW - Hyaluronic Acid -- metabolism KW - Extracellular Matrix -- chemistry KW - Nerve Growth Factors -- genetics KW - Nerve Growth Factors -- chemistry KW - Eye Proteins -- genetics KW - Serpins -- metabolism KW - Serpins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69826085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Pigment+epithelium-derived+factor+binds+to+hyaluronan.+Mapping+of+a+hyaluronan+binding+site.&rft.au=Becerra%2C+S+Patricia%3BPerez-Mediavilla%2C+L+Alberto%3BWeldon%2C+John+E%3BLocatelli-Hoops%2C+Silvia%3BSenanayake%2C+Preenie%3BNotari%2C+Luigi%3BNotario%2C+Vicente%3BHollyfield%2C+Joe+G&rft.aulast=Becerra&rft.aufirst=S&rft.date=2008-11-28&rft.volume=283&rft.issue=48&rft.spage=33310&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M801287200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-29 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11131-5 [11562499] J Biol Chem. 2007 Mar 2;282(9):6661-7 [17202143] J Cell Sci. 2001 Dec;114(Pt 24):4421-8 [11792807] J Biol Chem. 2002 Feb 15;277(7):4593-6 [11717318] J Biol Chem. 2002 Feb 15;277(7):4575-9 [11717319] Trends Mol Med. 2002 Jul;8(7):330-4 [12114112] J Biol Chem. 2002 Nov 22;277(47):45400-7 [12237317] BMC Biochem. 2003 Feb 19;4:1 [12625842] Biochemistry. 2003 Mar 25;42(11):3160-7 [12641447] Nat Med. 2003 Jun;9(6):774-80 [12740569] Mol Ther. 2003 Jul;8(1):72-9 [12842430] Nat Rev Neurosci. 2003 Aug;4(8):628-36 [12894238] Cancer Res. 2003 Sep 15;63(18):5685-90 [14522884] J Biol Chem. 1999 Oct 29;274(44):31605-12 [10531367] Invest Ophthalmol Vis Sci. 1999 Nov;40(12):2767-9 [10549633] Glycobiology. 2000 Mar;10(3):273-81 [10704526] Glycobiology. 2000 Mar;10(3):283-93 [10704527] J Cell Sci. 2001 Jan;114(Pt 1):199-205 [11112703] Exp Eye Res. 2004 Feb;78(2):223-34 [14729355] J Biol Chem. 2004 May 28;279(22):23142-50 [15044457] Cell. 1977 May;11(1):223-32 [194704] Ciba Found Symp. 1989;143:150-9; discussion 159-69, 281-5 [2680343] Biochemistry. 1989 Nov 14;28(23):8951-66 [2690952] Exp Eye Res. 1991 Sep;53(3):411-4 [1936177] J Cell Biol. 1992 Jan;116(2):545-57 [1730767] J Exp Med. 1992 Aug 1;176(2):623-7 [1500863] Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1526-30 [8434014] Cancer Res. 1994 Jan 15;54(2):422-6 [7506122] Growth Factors. 1994;10(4):289-97 [7803045] Protein Expr Purif. 1995 Aug;6(4):447-56 [8527930] Am J Pathol. 1996 Jun;148(6):1721-6 [8669457] J Exp Med. 1996 Apr 1;183(4):1663-8 [8666924] Invest Ophthalmol Vis Sci. 1996 Sep;37(10):1984-93 [8814138] Protein Sci. 1996 Dec;5(12):2575-82 [8976566] Invest Ophthalmol Vis Sci. 1996 Dec;37(13):2759-67 [8977492] Exp Eye Res. 1997 Nov;65(5):603-8 [9367640] Arch Biochem Biophys. 1998 Feb 1;350(1):26-35 [9466816] J Biol Chem. 1998 Jun 12;273(24):15125-30 [9614124] Exp Eye Res. 1998 Feb;66(2):241-8 [9533850] Biochim Biophys Acta. 1998 Jun 16;1398(2):203-14 [9689919] Biochemistry. 1998 Jul 28;37(30):10643-52 [9692954] J Biol Chem. 1998 Nov 20;273(47):31599-606 [9813076] Glycobiology. 1998 Dec;8(12):1227-35 [9858645] J Pediatr Surg. 2005 Jan;40(1):236-43 [15868591] Cancer Res. 2005 Jun 15;65(12):5144-52 [15958558] Biochem Biophys Res Commun. 2005 Sep 30;335(3):756-61 [16102727] Curr Drug Targets. 2005 Sep;6(6):665-82 [16178800] Exp Eye Res. 2006 May;82(5):739-40 [16364294] Cancer Res. 2006 Nov 1;66(21):10233-7 [17079438] J Mol Med (Berl). 2007 Jan;85(1):15-22 [17106733] Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3287-93 [11726635] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M801287200 ER - TY - JOUR T1 - PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release AN - 19592434; 8820334 AB - Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for their biological function. We found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three primary metabolites; the major one is the corresponding des-nitroimidazole (des-nitro). When derivatives of PA-824 were used, the amount of des-nitro metabolite formed was highly correlated with anaerobic killing of Mycobacterium tuberculosis (Mtb). Des-nitro metabolite formation generated reactive nitrogen species, including nitric oxide (NO), which are the major effectors of the anaerobic activity of these compounds. Furthermore, NO scavengers protected the bacilli from the lethal effects of the drug. Thus, these compounds may act as intracellular NO donors and could augment a killing mechanism intrinsic to the innate immune system. JF - Science (Washington) AU - Singh, Ramandeep AU - Manjunatha, Ujjini AU - Boshoff, Helena IM AU - Ha, Young Hwan AU - Niyomrattanakit, Pornwaratt AU - Ledwidge, Richard AU - Dowd, Cynthia S AU - Lee, Ill Young AU - Kim, Pilho AU - Zhang, Liang AU - Kang, Sunhee AU - Keller, Thomas H AU - Jiricek, Jan AU - Barry, Clifton E 3rd AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., cbarry@mail.nih.gov Y1 - 2008/11/28/ PY - 2008 DA - 2008 Nov 28 SP - 1392 EP - 1395 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 322 IS - 5906 SN - 0036-8075, 0036-8075 KW - Microbiology Abstracts B: Bacteriology KW - Nitroreductase KW - Bacilli KW - prodrugs KW - Immune system KW - nitroimidazoles KW - Nitric oxide KW - Metabolites KW - Tuberculosis KW - reactive nitrogen species KW - Immunosuppressive agents KW - Mycobacterium tuberculosis KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19592434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=PA-824+Kills+Nonreplicating+Mycobacterium+tuberculosis+by+Intracellular+NO+Release&rft.au=Singh%2C+Ramandeep%3BManjunatha%2C+Ujjini%3BBoshoff%2C+Helena+IM%3BHa%2C+Young+Hwan%3BNiyomrattanakit%2C+Pornwaratt%3BLedwidge%2C+Richard%3BDowd%2C+Cynthia+S%3BLee%2C+Ill+Young%3BKim%2C+Pilho%3BZhang%2C+Liang%3BKang%2C+Sunhee%3BKeller%2C+Thomas+H%3BJiricek%2C+Jan%3BBarry%2C+Clifton+E+3rd&rft.aulast=Singh&rft.aufirst=Ramandeep&rft.date=2008-11-28&rft.volume=322&rft.issue=5906&rft.spage=1392&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1164571 L2 - http://www.sciencemag.org/cgi/reprint/322/5906/1392.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nitroreductase; Bacilli; prodrugs; Immune system; nitroimidazoles; reactive nitrogen species; Tuberculosis; Metabolites; Nitric oxide; Immunosuppressive agents; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1126/science.1164571 ER - TY - JOUR T1 - Stromal gene signatures in large-B-cell lymphomas. AN - 69834606; 19038878 AB - The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma. Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear. We profiled gene expression in pretreatment biopsy specimens from 181 patients with diffuse large-B-cell lymphoma who received CHOP and 233 patients with this disease who received R-CHOP. A multivariate gene-expression-based survival-predictor model derived from a training group was tested in a validation group. A multivariate model created from three gene-expression signatures--termed "germinal-center B-cell," "stromal-1," and "stromal-2"--predicted survival both in patients who received CHOP and patients who received R-CHOP. The prognostically favorable stromal-1 signature reflected extracellular-matrix deposition and histiocytic infiltration. By contrast, the prognostically unfavorable stromal-2 signature reflected tumor blood-vessel density. Survival after treatment of diffuse large-B-cell lymphoma is influenced by differences in immune cells, fibrosis, and angiogenesis in the tumor microenvironment. 2008 Massachusetts Medical Society JF - The New England journal of medicine AU - Lenz, G AU - Wright, G AU - Dave, S S AU - Xiao, W AU - Powell, J AU - Zhao, H AU - Xu, W AU - Tan, B AU - Goldschmidt, N AU - Iqbal, J AU - Vose, J AU - Bast, M AU - Fu, K AU - Weisenburger, D D AU - Greiner, T C AU - Armitage, J O AU - Kyle, A AU - May, L AU - Gascoyne, R D AU - Connors, J M AU - Troen, G AU - Holte, H AU - Kvaloy, S AU - Dierickx, D AU - Verhoef, G AU - Delabie, J AU - Smeland, E B AU - Jares, P AU - Martinez, A AU - Lopez-Guillermo, A AU - Montserrat, E AU - Campo, E AU - Braziel, R M AU - Miller, T P AU - Rimsza, L M AU - Cook, J R AU - Pohlman, B AU - Sweetenham, J AU - Tubbs, R R AU - Fisher, R I AU - Hartmann, E AU - Rosenwald, A AU - Ott, G AU - Muller-Hermelink, H-K AU - Wrench, D AU - Lister, T A AU - Jaffe, E S AU - Wilson, W H AU - Chan, W C AU - Staudt, L M AU - Lymphoma/Leukemia Molecular Profiling Project AD - Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. ; Lymphoma/Leukemia Molecular Profiling Project Y1 - 2008/11/27/ PY - 2008 DA - 2008 Nov 27 SP - 2313 EP - 2323 VL - 359 IS - 22 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Murine-Derived KW - Immunologic Factors KW - Rituximab KW - 4F4X42SYQ6 KW - Vincristine KW - 5J49Q6B70F KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Extracellular Matrix -- genetics KW - Immunologic Factors -- administration & dosage KW - Humans KW - Prognosis KW - Disease Progression KW - Antibodies, Monoclonal -- administration & dosage KW - Multivariate Analysis KW - Kaplan-Meier Estimate KW - Gene Expression Regulation, Neoplastic KW - Germinal Center KW - Neovascularization, Pathologic -- genetics KW - Antineoplastic Combined Chemotherapy Protocols KW - Middle Aged KW - Genes, MHC Class II KW - Gene Expression Profiling KW - Lymphoma, Large B-Cell, Diffuse -- mortality KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - Lymphoma, Large B-Cell, Diffuse -- pathology KW - Gene Expression KW - Stromal Cells -- metabolism KW - Stromal Cells -- pathology KW - Lymphoma, Large B-Cell, Diffuse -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69834606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Stromal+gene+signatures+in+large-B-cell+lymphomas.&rft.au=Lenz%2C+G%3BWright%2C+G%3BDave%2C+S+S%3BXiao%2C+W%3BPowell%2C+J%3BZhao%2C+H%3BXu%2C+W%3BTan%2C+B%3BGoldschmidt%2C+N%3BIqbal%2C+J%3BVose%2C+J%3BBast%2C+M%3BFu%2C+K%3BWeisenburger%2C+D+D%3BGreiner%2C+T+C%3BArmitage%2C+J+O%3BKyle%2C+A%3BMay%2C+L%3BGascoyne%2C+R+D%3BConnors%2C+J+M%3BTroen%2C+G%3BHolte%2C+H%3BKvaloy%2C+S%3BDierickx%2C+D%3BVerhoef%2C+G%3BDelabie%2C+J%3BSmeland%2C+E+B%3BJares%2C+P%3BMartinez%2C+A%3BLopez-Guillermo%2C+A%3BMontserrat%2C+E%3BCampo%2C+E%3BBraziel%2C+R+M%3BMiller%2C+T+P%3BRimsza%2C+L+M%3BCook%2C+J+R%3BPohlman%2C+B%3BSweetenham%2C+J%3BTubbs%2C+R+R%3BFisher%2C+R+I%3BHartmann%2C+E%3BRosenwald%2C+A%3BOtt%2C+G%3BMuller-Hermelink%2C+H-K%3BWrench%2C+D%3BLister%2C+T+A%3BJaffe%2C+E+S%3BWilson%2C+W+H%3BChan%2C+W+C%3BStaudt%2C+L+M%3BLymphoma%2FLeukemia+Molecular+Profiling+Project&rft.aulast=Lenz&rft.aufirst=G&rft.date=2008-11-27&rft.volume=359&rft.issue=22&rft.spage=2313&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMoa0802885 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-04 N1 - Date created - 2008-11-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 2009 Jun 25;360(26):2794-5 [19553658] N Engl J Med. 2008 Nov 27;359(22):2379-81 [19038884] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1056/NEJMoa0802885 ER - TY - JOUR T1 - Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. AN - 66692353; 18973327 AB - O(6)-Benzylguanine is an irreversible inactivator of O(6)-alkylguanine-DNA alkyltransferase currently in clinical trials to overcome alkyltransferase-mediated resistance to certain cancer chemotherapeutic alkylating agents. In order to produce more soluble alkyltransferase inhibitors, we have synthesized three aminomethyl-substituted O(6)-benzylguanines and the three methyl analogs and found that the substitution of aminomethyl at the meta-position greatly enhances inactivation of alkyltransferase, whereas para-substitution has little effect and ortho-substitution virtually eliminates activity. Molecular modeling of their interactions with alkyltransferase provided a molecular explanation for these results. The square of the correlation coefficient (R(2)) obtained between E-model scores (obtained from GLIDE XP/QPLD docking calculations) vs log(ED(50)) values via a linear regression analysis was 0.96. The models indicate that the ortho-substitution causes a steric clash interfering with binding, whereas the meta-aminomethyl substitution allows an interaction of the amino group to generate an additional hydrogen bond with the protein. JF - Journal of medicinal chemistry AU - Pauly, Gary T AU - Loktionova, Natalia A AU - Fang, Qingming AU - Vankayala, Sai Lakshmana AU - Guida, Wayne C AU - Pegg, Anthony E AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, P.O. Box B, Building 538, Frederick, Maryland 21702, USA. Y1 - 2008/11/27/ PY - 2008 DA - 2008 Nov 27 SP - 7144 EP - 7153 VL - 51 IS - 22 KW - Enzyme Inhibitors KW - 0 KW - Ligands KW - O(6)-benzylguanine KW - 01KC87F8FE KW - Guanine KW - 5Z93L87A1R KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Index Medicus KW - Molecular Structure KW - Stereoisomerism KW - Computer Simulation KW - Models, Molecular KW - Humans KW - Models, Chemical KW - Hydrogen Bonding KW - Structure-Activity Relationship KW - O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors KW - Guanine -- chemistry KW - Enzyme Inhibitors -- chemistry KW - Enzyme Inhibitors -- pharmacology KW - Guanine -- chemical synthesis KW - Guanine -- analogs & derivatives KW - Enzyme Inhibitors -- chemical synthesis KW - Guanine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66692353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Substitution+of+aminomethyl+at+the+meta-position+enhances+the+inactivation+of+O6-alkylguanine-DNA+alkyltransferase+by+O6-benzylguanine.&rft.au=Pauly%2C+Gary+T%3BLoktionova%2C+Natalia+A%3BFang%2C+Qingming%3BVankayala%2C+Sai+Lakshmana%3BGuida%2C+Wayne+C%3BPegg%2C+Anthony+E&rft.aulast=Pauly&rft.aufirst=Gary&rft.date=2008-11-27&rft.volume=51&rft.issue=22&rft.spage=7144&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm800675p LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-03 N1 - Date created - 2009-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 1999 Dec;291(3):1269-75 [10565851] Neuro Oncol. 2008 Jun;10(3):320-9 [18403491] EMBO J. 2000 Apr 3;19(7):1719-30 [10747039] Mutat Res. 2000 Apr;462(2-3):83-100 [10767620] J Med Chem. 2000 Nov 2;43(22):4071-83 [11063604] Biochem J. 2000 Apr 15;347(Pt 2):519-26 [10749682] J Pharmacol Exp Ther. 2001 Mar;296(3):958-65 [11181929] Biochemistry. 2002 Jul 9;41(27):8689-97 [12093287] Nat Biotechnol. 2003 Jan;21(1):86-9 [12469133] Lancet Oncol. 2003 Jan;4(1):37-44 [12517538] Carcinogenesis. 2003 Apr;24(4):625-35 [12727789] Biochemistry. 2003 Sep 23;42(37):10965-70 [12974631] J Med Chem. 2004 Mar 25;47(7):1683-93 [15027859] J Med Chem. 2004 Mar 25;47(7):1739-49 [15027865] J Med Chem. 2004 Mar 25;47(7):1750-9 [15027866] Nat Rev Cancer. 2004 Apr;4(4):296-307 [15057289] J Med Chem. 2004 Jul 15;47(15):3887-91 [15239666] Nat Struct Mol Biol. 2004 Aug;11(8):714-20 [15221026] Proc Natl Acad Sci U S A. 1990 Jul;87(14):5368-72 [2164681] Cancer Res. 1991 Jul 1;51(13):3367-72 [1647266] J Med Chem. 1992 Nov 13;35(23):4486-91 [1447749] Biochemistry. 1993 Nov 16;32(45):11998-2006 [8218276] Biochemistry. 1994 Jul 19;33(28):8385-90 [8031773] J Biol Chem. 1995 Mar 10;270(10):5375-80 [7534295] Biochem Pharmacol. 1997 May 15;53(10):1559-64 [9260884] J Med Chem. 1998 Dec 17;41(26):5265-71 [9857094] Clin Cancer Res. 1997 Jun;3(6):837-47 [9815757] Bioorg Med Chem. 2005 Jun 1;13(11):3821-39 [15863008] J Comput Chem. 2005 Jul 15;26(9):915-31 [15841474] J Clin Oncol. 2005 Oct 1;23(28):7178-87 [16192602] J Clin Oncol. 2005 Oct 20;23(30):7646-53 [16234526] Clin Cancer Res. 2005 Nov 1;11(21):7861-5 [16278409] Clin Cancer Res. 2006 Mar 1;12(5):1577-84 [16533784] Neurol Res. 2006 Jul;28(5):542-8 [16808887] J Med Chem. 2006 Oct 19;49(21):6177-96 [17034125] Curr Drug Deliv. 2007 Apr;4(2):169-80 [17456036] Cancer Chemother Pharmacol. 2007 Aug;60(3):415-21 [17354015] DNA Repair (Amst). 2007 Aug 1;6(8):1100-15 [17485252] Expert Opin Investig Drugs. 2007 Oct;16(10):1573-84 [17922622] J Med Chem. 2007 Oct 18;50(21):5193-201 [17880193] Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6712-8 [18006772] Biochem Pharmacol. 2008 Feb 1;75(3):618-26 [17996846] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800675p ER - TY - JOUR T1 - A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. AN - 69794523; 18951897 AB - We identified a novel inhibitor of growth family member 2 (ING2) isoform, ING2b, which shares exon 2 with ING2a, but lacks the N-terminal p53 binding region. Contrary to ING2a, ING2b's promoter has no p53 binding sites. Consistently, activation of p53 led to suppression of ING2a, leaving ING2b unaffected. Through isoform-specific targeting, we showed that ING2a knockdown suppressed cell growth only in the presence of p53, ING2b knockdown had no effect on cell growth, and knockdown of both induced cell cycle arrest and apoptosis independently of p53. ING2a and ING2b have compensatory roles that protect cells from cell cycle arrest and apoptosis and may be involved in development of chemotherapeutic resistance. JF - FEBS letters AU - Unoki, Motoko AU - Kumamoto, Kensuke AU - Robles, Ana I AU - Shen, Jiang Cheng AU - Zheng, Zhi-Ming AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr., Bldg. 37, Rm. 3068, Bethesda, MD 20892, USA. Y1 - 2008/11/26/ PY - 2008 DA - 2008 Nov 26 SP - 3868 EP - 3874 VL - 582 IS - 28 SN - 0014-5793, 0014-5793 KW - Homeodomain Proteins KW - 0 KW - ING2 protein, human KW - Protein Isoforms KW - Receptors, Cytoplasmic and Nuclear KW - Tumor Suppressor Protein p53 KW - Tumor Suppressor Proteins KW - Index Medicus KW - Animals KW - Promoter Regions, Genetic KW - Gene Knockdown Techniques KW - Protein Isoforms -- metabolism KW - Humans KW - Molecular Sequence Data KW - Mice KW - Gene Expression Regulation KW - Amino Acid Sequence KW - Protein Isoforms -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Cell Line KW - Binding Sites KW - Apoptosis -- genetics KW - Homeodomain Proteins -- genetics KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Homeodomain Proteins -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Cell Cycle -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69794523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=A+novel+ING2+isoform%2C+ING2b%2C+synergizes+with+ING2a+to+prevent+cell+cycle+arrest+and+apoptosis.&rft.au=Unoki%2C+Motoko%3BKumamoto%2C+Kensuke%3BRobles%2C+Ana+I%3BShen%2C+Jiang+Cheng%3BZheng%2C+Zhi-Ming%3BHarris%2C+Curtis+C&rft.aulast=Unoki&rft.aufirst=Motoko&rft.date=2008-11-26&rft.volume=582&rft.issue=28&rft.spage=3868&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2008.10.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-02 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2001 May 15;29(10):2052-8 [11353074] Oncogene. 2003 Apr 10;22(14):2172-85 [12687019] Cancer Res. 2003 May 15;63(10):2373-8 [12750254] Mol Cell. 2006 Jan 6;21(1):51-64 [16387653] FEBS Lett. 2006 Jul 10;580(16):3787-93 [16782091] Int J Cancer. 2008 Oct 1;123(7):1483-90 [18636562] Nature. 2006 Jul 6;442(7098):100-3 [16728977] J Biol Chem. 2006 Nov 10;281(45):34677-86 [16973615] Cancer Res. 2008 May 1;68(9):3193-203 [18451145] Mol Cancer Ther. 2008 Jul;7(7):1985-92 [18645008] Nature. 2006 Jul 6;442(7098):96-9 [16728974] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.febslet.2008.10.024 ER - TY - JOUR T1 - Revised Assignment of Absolute Configuration of the cis- and trans-N6-Deoxyadenosine Adducts at C14 of (c)-11*b,12*a-Dihydroxy-13*a,14*a-epoxy-11,12,13,14-te trahydrodibenzo[a,l]pyrene by Stereoselective Synthesis AN - 754548251; 13300947 AB - We have reassigned relative and absolute configurations by unambiguous stereoselective syntheses of the cis- (13S and 13R) and trans-N6-deoxyadenosine (dAdo) adduct diastereomers (14S and 14R) derived from (c)-11*b,12*a-dihydroxy-13*a,14*a-epoxy-11,12,13,14-te trahydrodibenzo[a,l]pyrene (DB[a,l]P DE-2), previously reported by Li et al. [(1999) Chem. Res. Toxicol. 12, 758-767]. Two stereoselective methods, asymmetric aminohydroxylation of the (c)-trans-11,12-dihydrodiol (3) with 3',5'-di-O-(tert -butyldimethylsilyl)-2'-deoxyadenosine (4) and the highly stereoselective cis addition of 4 to (c)-DB[a,l]P DE-2 in hexafluoropropan-2-ol (HFP), were employed. Both afforded a 1:1 mixture of the cis-N6-dAdo adduct diastereomers, which were separated as triacetates (5S and 5R) in comparable yields (80%). The corresponding trans adduct diastereomers (10S and 10R) were obtained by coupling the aminotriol derived from trans opening of (c)-DB[a,l]P DE-2 with 6-fluoro-(2'-deoxy-3,5-di-tert-butyldimethylsilyloxy-*b-d-erythro -pentafuranosyl)purine (9) and subsequent acetylation in 70% yield. The cis-5S and -5R and trans-10S and -10R were separately treated with 7% HF-pyridine followed by ammonolysis in NH3-saturated MeOH to give the dAdo adducts with all hydroxyl groups free (13S, 13R, 14S, and14R). Comparison of the 1H NMR and CD spectra of these presently synthesized dAdo adducts with spectra of the previously reported compounds revealed that the interpretation of the 1H NMR and CD spectra and assignment of the relative stereochemistry (cis/trans) and absolute configuration made by Li et al. were at variance with our results. The above highly stereoselective syntheses of (c)-DB[a,l]P DE-2 adducted dAdo derivatives enabled efficient preparation of each of the four possible stereoisomeric 5'-dimethoxytrityl-3'-phosphoramidites for use in oligonucleotide synthesis. JF - Chemical Research in Toxicology AU - Yagi, Haruhiko AU - Frank, Heinrich AU - Seidel, Albrecht AU - Jerina, Donald M AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892, and Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer-Foundation, Lurup 4, D-22927 Grosshansdorf, Federal Republic of Germany Y1 - 2008/11/21/ PY - 2008 DA - 2008 Nov 21 SP - 2379 EP - 2392 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA VL - 21 IS - 12 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts KW - Acetylation KW - Adducts KW - N.M.R. KW - Absolute configuration KW - Oligonucleotides KW - Stereochemistry KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754548251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Revised+Assignment+of+Absolute+Configuration+of+the+cis-+and+trans-N6-Deoxyadenosine+Adducts+at+C14+of+%28c%29-11*b%2C12*a-Dihydroxy-13*a%2C14*a-epoxy-11%2C12%2C13%2C14-te+trahydrodibenzo%5Ba%2Cl%5Dpyrene+by+Stereoselective+Synthesis&rft.au=Yagi%2C+Haruhiko%3BFrank%2C+Heinrich%3BSeidel%2C+Albrecht%3BJerina%2C+Donald+M&rft.aulast=Yagi&rft.aufirst=Haruhiko&rft.date=2008-11-21&rft.volume=21&rft.issue=12&rft.spage=2379&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx800268f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Acetylation; Adducts; N.M.R.; Absolute configuration; Oligonucleotides; Stereochemistry DO - http://dx.doi.org/10.1021/tx800268f ER - TY - JOUR T1 - Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs. AN - 69784388; 18956868 AB - Although O(2)-(2,4-dinitrophenyl) derivatives of diazeniumdiolate-based nitric oxide (NO) prodrugs bearing a free carboxylic acid group were activated by glutathione to release NO, these compounds were poor sources of intracellular NO and showed diminished antiproliferative activity against human leukemia HL-60 cells. The carboxylic acid esters of these prodrugs, however, were found to be superior sources of intracellular NO and potent inhibitors of HL-60 cell proliferation. JF - Organic letters AU - Chakrapani, Harinath AU - Maciag, Anna E AU - Citro, Michael L AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. chakrah@ncifcrf.gov Y1 - 2008/11/20/ PY - 2008 DA - 2008 Nov 20 SP - 5155 EP - 5158 VL - 10 IS - 22 KW - Azo Compounds KW - 0 KW - Prodrugs KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Rats KW - Cell Proliferation -- drug effects KW - Permeability KW - Animals KW - Intracellular Space -- metabolism KW - Humans KW - Cell Line, Tumor KW - Prodrugs -- chemistry KW - Azo Compounds -- chemistry KW - Prodrugs -- pharmacology KW - Nitric Oxide -- pharmacology KW - Nitric Oxide -- metabolism KW - Nitric Oxide -- chemistry KW - Prodrugs -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69784388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=Cell-permeable+esters+of+diazeniumdiolate-based+nitric+oxide+prodrugs.&rft.au=Chakrapani%2C+Harinath%3BMaciag%2C+Anna+E%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2008-11-20&rft.volume=10&rft.issue=22&rft.spage=5155&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=1523-7052&rft_id=info:doi/10.1021%2Fol8020989 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-15 N1 - Date created - 2008-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ol8020989 ER - TY - JOUR T1 - A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein. AN - 69783523; 18817840 AB - Allyl acetate (AAC), allyl alcohol (AAL), and acrolein (ACR) are used in the manufacture of detergents, plastics, pharmaceuticals, and chemicals and as agricultural agents. A metabolic relationship exists between these chemicals in which allyl acetate is metabolized to allyl alcohol and subsequently to the highly reactive, alpha,beta-unsaturated aldehyde, acrolein. Due to the weaker reactivity of the protoxicants, allyl acetate and allyl alcohol, relative to acrolien we hypothesized the protoxicants would attain greater systemic exposure and therefore deliver higher doses of acrolein to the internal organs. By extension, the higher systemic exposure to acrolein we hypothesized should lead to more internal organ toxicity in the allyl acetate and allyl alcohol treated animals relative to those treated with acrolein. To address our hypothesis we compared the range of toxicities produced by all three chemicals in male and female Fischer 344/N rats and B6C3F1 mice exposed 5 days a week for 3 months by gavage in 0.5% methylcellulose. Rats (10/group) were dosed with 0-100mg/kg allyl acetate, 0-25mg/kg allyl alcohol, or 0-10mg/kg acrolein. Mice (10/group) were dosed with 0-125mg/kg allyl acetate, 0-50mg/kg allyl alcohol, or 0-20mg/kg acrolein. The highest dose of allyl acetate and acrolein decreased survival in both mice and rats. The primary target organ for the toxicity of all three chemicals in both species and sexes was the forestomach; squamous epithelial hyperplasia was observed following exposure to each chemical. In both species the highest allyl acetate dose group exhibited forestomach epithelium necrosis and hemorrhage and the highest dose of acrolein led to glandular stomach hemorrhage. Liver histopathology was the most apparent with allyl acetate, was also observed with allyl alcohol, but was not observed with acrolein. All chemicals had effects on the hematopoietic system with allyl acetate having the most pronounced effect. When dosed at quantities limited by toxicity, allyl acetate and allyl alcohol produce higher levels of urinary mercapturic acids than the minimally toxic dose of acrolein. This observation is likely due to biotransformation of allyl acetate and ally alcohol to acrolein that occurs after absorption and suggests that these chemicals are protoxicants that increase systemic exposure of acrolein. Increased systemic exposure to acrolein is likely responsible for the differences in hepatic toxicological profile observed with these chemicals. JF - Toxicology AU - Auerbach, Scott S AU - Mahler, Joel AU - Travlos, Gregory S AU - Irwin, Richard D AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States. auerbachs@niehs.nih.gov Y1 - 2008/11/20/ PY - 2008 DA - 2008 Nov 20 SP - 79 EP - 88 VL - 253 IS - 1-3 SN - 0300-483X, 0300-483X KW - Acetates KW - 0 KW - Allyl Compounds KW - Propanols KW - allyl alcohol KW - 3W678R12M0 KW - Acrolein KW - 7864XYD3JJ KW - S-(3-hydroxypropyl)cysteine N-acetate KW - BFU3149V95 KW - allyl acetate KW - E4U5E5990I KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Lymphoid Tissue -- pathology KW - Acetylcysteine -- analogs & derivatives KW - Mice KW - Hematopoietic System -- drug effects KW - Gastric Mucosa -- pathology KW - Stomach -- drug effects KW - Blood Cell Count KW - Rats KW - Acetylcysteine -- urine KW - Stomach -- pathology KW - Rats, Inbred F344 KW - Survival Rate KW - Liver -- drug effects KW - Toxicity Tests KW - Gastric Mucosa -- drug effects KW - Lymphoid Tissue -- drug effects KW - Male KW - Female KW - Acetates -- administration & dosage KW - Propanols -- toxicity KW - Propanols -- administration & dosage KW - Allyl Compounds -- administration & dosage KW - Allyl Compounds -- toxicity KW - Acetates -- toxicity KW - Acrolein -- toxicity KW - Acrolein -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69783523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=A+comparative+90-day+toxicity+study+of+allyl+acetate%2C+allyl+alcohol+and+acrolein.&rft.au=Auerbach%2C+Scott+S%3BMahler%2C+Joel%3BTravlos%2C+Gregory+S%3BIrwin%2C+Richard+D&rft.aulast=Auerbach&rft.aufirst=Scott&rft.date=2008-11-20&rft.volume=253&rft.issue=1-3&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2008.08.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hepatology. 1985 Nov-Dec;5(6):1179-82 [2933316] Mutat Res. 1985 Jan-Mar;153(1-2):57-77 [3883152] Toxicol Sci. 2000 Sep;57(1):6-15 [10966506] Circulation. 2002 Jun 25;105(25):2968-73 [12081989] Proc Nutr Soc. 2004 Feb;63(1):49-63 [15099407] J Natl Cancer Inst. 2004 Jul 7;96(13):1023-9 [15240786] Toxicol Pathol. 2004 Jul-Aug;32(4):393-401 [15307212] Genomics. 2004 Oct;84(4):661-8 [15475243] Biometrics. 1971 Mar;27(1):103-17 [5547548] Biometrics. 1972 Jun;28(2):519-31 [5037867] Biochem J. 1973 Aug;134(4):1093-1101 [4762754] Br J Pharmacol. 1975 Jun;54(2):268P [1148549] J Pharmacol Exp Ther. 1987 Oct;243(1):20-6 [3668850] Toxicol Ind Health. 1987 Sep;3(3):337-45 [3686537] Carcinogenesis. 1989 Jan;10(1):87-90 [2642752] J Appl Toxicol. 1989 Aug;9(4):235-8 [2778257] Carcinogenesis. 1990 Mar;11(3):497-8 [2311195] Biochem Pharmacol. 1991 Jan 1;41(1):146-8 [1898849] Environ Health Perspect. 1990 Jul;87:227-32 [2269229] Mutat Res. 1991 Mar-Apr;259(3-4):363-85 [2017217] Carcinogenesis. 1991 Aug;12(8):1483-90 [1860170] J Appl Toxicol. 1992 Apr;12(2):131-9 [1556380] Cancer Res. 1992 Jul 1;52(13):3577-81 [1617627] Mutat Res. 1994 May;321(3):119-26 [7513061] Rev Environ Contam Toxicol. 1995;144:95-146 [8599034] J Appl Toxicol. 1996 Sep-Oct;16(5):449-57 [8889798] World Health Organ Tech Rep Ser. 1997;868:i-viii, 1-69 [9385867] Cancer Res. 2005 Feb 15;65(4):1265-70 [15735011] Drug Metab Pharmacokinet. 2006 Jun;21(3):173-85 [16858120] Am J Hum Genet. 2006 Sep;79(3):586-92 [16909399] Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15404-9 [17030796] Toxic Rep Ser. 2006 Jul;(48):1-73, A1-H10 [17160105] Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16621-6 [17921251] Biometrics. 1977 Jun;33(2):386-9 [884197] Toxicol Appl Pharmacol. 1978 Aug;45(2):377-89 [705781] J Natl Cancer Inst. 1979 Apr;62(4):957-74 [285297] Drug Metab Dispos. 1987 May-Jun;15(3):356-62 [2886311] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2008.08.014 ER - TY - JOUR T1 - Recent Trends in Breast Cancer Among Younger Women in the United States AN - 19754752; 8818195 AB - Increases in the incidence of postmenopausal breast cancers have been linked to screening and menopausal hormone use, but younger women have received less attention. Thus, we analyzed trends in breast cancer incidence (N = 387 231) using the National Cancer Institute's Surveillance, Epidemiology, and End Results Program 13-Registry database (1992-2004). Whites had higher incidence rates than blacks after age 40 years, but the reverse was true among younger women (black-white crossover). Among younger women, the rate per 100 000 woman-years was 16.8 for black vs 15.1 for white women; the highest black-white incidence rate ratio (IRR) was seen among women younger than 30 years (IRR = 1.52, 95% confidence interval = 1.34 to 1.73). This risk pattern was not observed in other ethnic groups. The black-white crossover among younger women was largely restricted to breast cancers with favorable tumor characteristics. The annual percentage change in the incidence of invasive breast cancers decreased modestly among older women but increased among younger ([Lt]40 years) white women. Continued surveillance of trends is needed, particularly for molecular subtypes that preferentially occur among young women. JF - Journal of the National Cancer Institute AU - Brinton, Louise A AU - Sherman, Mark E AU - Carreon, JDaniel AU - Anderson, William F AD - Affiliations of authors: Hormonal and Reproductive Epidemiology Branch (LAB, MES, JDC) and Biostatistics Branch (WFA), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, brinton@nih.gov Y1 - 2008/11/19/ PY - 2008 DA - 2008 Nov 19 SP - 1643 EP - 1648 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 22 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Age KW - post-menopause KW - tumors KW - Hormones KW - USA KW - Breast cancer KW - Females KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19754752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Recent+Trends+in+Breast+Cancer+Among+Younger+Women+in+the+United+States&rft.au=Brinton%2C+Louise+A%3BSherman%2C+Mark+E%3BCarreon%2C+JDaniel%3BAnderson%2C+William+F&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2008-11-19&rft.volume=100&rft.issue=22&rft.spage=1643&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn344 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Breast cancer; post-menopause; tumors; Females; Ethnic groups; Age; Hormones DO - http://dx.doi.org/10.1093/jnci/djn344 ER - TY - JOUR T1 - Calcium Plus Vitamin D Supplementation and the Risk of Breast Cancer AN - 19656507; 8818190 AB - Background Although some observational studies have associated higher calcium intake and especially higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk, no randomized trial has evaluated these relationships.Methods Postmenopausal women (N = 36282) who were enrolled in a Women's Health Initiative clinical trial were randomly assigned to 1000 mg of elemental calcium with 400 IU of vitamin D3 daily or placebo for a mean of 7.0 years to determine the effects of supplement use on incidence of hip fracture. Mammograms and breast exams were serially conducted. Invasive breast cancer was a secondary outcome. Baseline serum 25-hydroxyvitamin D levels were assessed in a nested case-control study of 1067 case patients and 1067 control subjects. A Cox proportional hazards model was used to estimate the risk of breast cancer associated with random assignment to calcium with vitamin D3. Associations between 25-hydroxyvitamin D serum levels and total vitamin D intake, body mass index (BMI), recreational physical activity, and breast cancer risks were evaluated using logistic regression models. Statistical tests were two-sided.Results Invasive breast cancer incidence was similar in the two groups (528 supplement vs 546 placebo; hazard ratio = 0.96; 95% confidence interval = 0.85 to 1.09). In the nested case-control study, no effect of supplement group assignment on breast cancer risk was seen. Baseline 25-hydroxyvitamin D levels were modestly correlated with total vitamin D intake (diet and supplements) (r = 0.19, P [Lt] .001) and were higher among women with lower BMI and higher recreational physical activity (both P [Lt] .001). Baseline 25-hydroxyvitamin D levels were not associated with breast cancer risk in analyses that were adjusted for BMI and physical activity (Ptrend = .20).Conclusions Calcium and vitamin D supplementation did not reduce invasive breast cancer incidence in postmenopausal women. In addition, 25-hydroxyvitamin D levels were not associated with subsequent breast cancer risk. These findings do not support a relationship between total vitamin D intake and 25-hydroxyvitamin D levels with breast cancer risk. JF - Journal of the National Cancer Institute AU - Chlebowski, Rowan T AU - Johnson, Karen C AU - Kooperberg, Charles AU - Pettinger, Mary AU - Wactawski-Wende, Jean AU - Rohan, Tom AU - Rossouw, Jacques AU - Lane, Dorothy AU - O'Sullivan, Mary Jo AU - Yasmeen, Shagufta AU - Hiatt, Robert A AU - Shikany, James M AU - Vitolins, Mara AU - Khandekar, Janu AU - Hubbell, FAllan AD - Affiliations of authors: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (RTC); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN (KCJ); Fred Hutchinson Cancer Research Center, Seattle, WA (CK, MP); Department of Social and Preventive Medicine, State University of New York, Buffalo, NY (JW-W); Albert Einstein College of Medicine, Bronx, NY (TR); National Heart, Lung, and Blood Institute, Bethesda, MD (JR); Department of Preventive Medicine, State University of New York, Stony Brook, NY (DL); Department of Obstetrics-Gynecology, University of Miami, Miami, FL (MJO); Department of Medicine, University of California at Davis, Sacramento, CA (SY); Department of Epidemiology & Biostatics, University of California at San Francisco, San Francisco, CA (RAH); Department of Preventive Medicine, University of Alabama, Birmingham, AL (JMS); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (MV, rchlebowski@gmail.com Y1 - 2008/11/19/ PY - 2008 DA - 2008 Nov 19 SP - 1581 EP - 1591 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 22 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Invasiveness KW - Calcium KW - Physical activity KW - Statistical analysis KW - 25-Hydroxyvitamin D KW - clinical trials KW - Clinical trials KW - vitamins KW - Post-menopause KW - body mass KW - Risk factors KW - Regression analysis KW - physical activity KW - Diets KW - post-menopause KW - Fractures KW - Cancer KW - Serum levels KW - hip fracture KW - Vitamin D KW - Vitamin D3 KW - Recreation areas KW - Dietary supplements KW - Breast cancer KW - Body mass index KW - Hip KW - R2 23060:Medical and environmental health KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19656507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Calcium+Plus+Vitamin+D+Supplementation+and+the+Risk+of+Breast+Cancer&rft.au=Chlebowski%2C+Rowan+T%3BJohnson%2C+Karen+C%3BKooperberg%2C+Charles%3BPettinger%2C+Mary%3BWactawski-Wende%2C+Jean%3BRohan%2C+Tom%3BRossouw%2C+Jacques%3BLane%2C+Dorothy%3BO%27Sullivan%2C+Mary+Jo%3BYasmeen%2C+Shagufta%3BHiatt%2C+Robert+A%3BShikany%2C+James+M%3BVitolins%2C+Mara%3BKhandekar%2C+Janu%3BHubbell%2C+FAllan&rft.aulast=Chlebowski&rft.aufirst=Rowan&rft.date=2008-11-19&rft.volume=100&rft.issue=22&rft.spage=1581&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn360 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Breast cancer; Cancer; vitamins; Calcium; physical activity; Recreation areas; post-menopause; clinical trials; hip fracture; Diets; body mass; 25-Hydroxyvitamin D; Vitamin D; Dietary supplements; Invasiveness; Physical activity; Clinical trials; Vitamin D3; Regression analysis; Post-menopause; Body mass index; Hip; Statistical analysis; Fractures; Risk factors; Serum levels DO - http://dx.doi.org/10.1093/jnci/djn360 ER - TY - CPAPER T1 - Diet, physical activity, and weight control services by US primary care physicians: influence on physicians' health behaviors and health status T2 - 2008 International Conference on Doctors Health AN - 41689820; 4992085 JF - 2008 International Conference on Doctors Health AU - Smith, Ashley AU - Klabunde, Carrie AU - Huang, Terry AU - Ballard-Barbash, Rachel Y1 - 2008/11/17/ PY - 2008 DA - 2008 Nov 17 KW - Physical activity KW - Diets KW - Obesity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41689820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Conference+on+Doctors+Health&rft.atitle=Diet%2C+physical+activity%2C+and+weight+control+services+by+US+primary+care+physicians%3A+influence+on+physicians%27+health+behaviors+and+health+status&rft.au=Smith%2C+Ashley%3BKlabunde%2C+Carrie%3BHuang%2C+Terry%3BBallard-Barbash%2C+Rachel&rft.aulast=Smith&rft.aufirst=Ashley&rft.date=2008-11-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Conference+on+Doctors+Health&rft.issn=&rft_id=info:doi/ L2 - http://web2.bma.org.uk/dhc.nsf/AttachmentsByTitle/PDFd4dfinalabstract/ $FILE/final+abstract+brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A guide for the perplexed: A rabbi's alternative to Bacon, and the challenges of post-genomic research T2 - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AN - 41952518; 5127766 JF - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AU - Ribeiro, Jose Y1 - 2008/11/16/ PY - 2008 DA - 2008 Nov 16 KW - Bacon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41952518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.atitle=A+guide+for+the+perplexed%3A+A+rabbi%27s+alternative+to+Bacon%2C+and+the+challenges+of+post-genomic+research&rft.au=Ribeiro%2C+Jose&rft.aulast=Ribeiro&rft.aufirst=Jose&rft.date=2008-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2008/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Midgut transcript expression profiling in Leishmania-infected sand flies T2 - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AN - 41920368; 5127740 JF - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AU - Jochim, Ryan Y1 - 2008/11/16/ PY - 2008 DA - 2008 Nov 16 KW - Sand KW - Transcription KW - Midgut KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41920368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.atitle=Midgut+transcript+expression+profiling+in+Leishmania-infected+sand+flies&rft.au=Jochim%2C+Ryan&rft.aulast=Jochim&rft.aufirst=Ryan&rft.date=2008-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2008/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using mathematical modeling and genetic algorithms to optimize the control of the Chagas disease vector, Triatoma infestans, in Arequipa, Peru T2 - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AN - 41918088; 5127720 JF - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AU - Levy, Michael Y1 - 2008/11/16/ PY - 2008 DA - 2008 Nov 16 KW - Peru KW - Algorithms KW - Mathematical models KW - Chagas' disease KW - Disease transmission KW - Hosts KW - Disease control KW - Triatoma infestans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41918088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.atitle=Using+mathematical+modeling+and+genetic+algorithms+to+optimize+the+control+of+the+Chagas+disease+vector%2C+Triatoma+infestans%2C+in+Arequipa%2C+Peru&rft.au=Levy%2C+Michael&rft.aulast=Levy&rft.aufirst=Michael&rft.date=2008-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2008/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The use of genetic markers to identify lung cancer in fine needle aspiration samples. AN - 69798844; 19010865 AB - We seek to establish a genetic test to identify lung cancer using cells obtained through computed tomography-guided fine needle aspiration (FNA). We selected regions of frequent copy number gains in chromosomes 1q32, 3q26, 5p15, and 8q24 in non-small cell lung cancer and tested their ability to determine the neoplastic state of cells obtained by FNA using fluorescent in situ hybridization. Two sets of samples were included. The pilot set included six paraffin-embedded, noncancerous lung tissues and 33 formalin-fixed FNA specimens. These 39 samples were used to establish the optimal fixation and single scoring criteria for the samples. The test set included 40 FNA samples. The results of the genetic test were compared with the cytology, pathology, and clinical follow-up for each case to assess the sensitivity and specificity of the genetic test. Nontumor lung tissues had or = 5 signals per nucleus in five or more cells for at least one marker. Among the 40 testing cases, 36 of 40 (90%) FNA samples were analyzable. Genetic analysis identified 15 cases as tumor and 21 cases as nontumor. Clinical and pathologic diagnoses confirmed the genetic test in 15 of 16 lung cancer cases regardless of tumor subtype, stage, or size and in 20 of 20 cases diagnosed as benign lung diseases. A set of only four genetic markers can distinguish the neoplastic state of lung lesion using small samples obtained through computed tomography-guided FNA. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Gill, Rajbir K AU - Vazquez, Madeline F AU - Kramer, Arin AU - Hames, Megan AU - Zhang, Lijuan AU - Heselmeyer-Haddad, Kerstin AU - Ried, Thomas AU - Shilo, Konstantin AU - Henschke, Claudia AU - Yankelevitz, David AU - Jen, Jin AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/11/15/ PY - 2008 DA - 2008 Nov 15 SP - 7481 EP - 7487 VL - 14 IS - 22 SN - 1078-0432, 1078-0432 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Surgery, Computer-Assisted KW - Humans KW - Tomography, X-Ray Computed KW - In Situ Hybridization, Fluorescence KW - Aged KW - Microscopy, Fluorescence KW - Aged, 80 and over KW - Adult KW - Chromosome Aberrations KW - Middle Aged KW - Female KW - Male KW - Biomarkers, Tumor -- genetics KW - Lung Neoplasms -- diagnosis KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- genetics KW - Carcinoma, Non-Small-Cell Lung -- diagnosis KW - Biopsy, Needle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69798844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=The+use+of+genetic+markers+to+identify+lung+cancer+in+fine+needle+aspiration+samples.&rft.au=Gill%2C+Rajbir+K%3BVazquez%2C+Madeline+F%3BKramer%2C+Arin%3BHames%2C+Megan%3BZhang%2C+Lijuan%3BHeselmeyer-Haddad%2C+Kerstin%3BRied%2C+Thomas%3BShilo%2C+Konstantin%3BHenschke%2C+Claudia%3BYankelevitz%2C+David%3BJen%2C+Jin&rft.aulast=Gill&rft.aufirst=Rajbir&rft.date=2008-11-15&rft.volume=14&rft.issue=22&rft.spage=7481&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-5242 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-05 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Vasc Interv Radiol. 2004 Feb;15(2 Pt 1):161-4 [14963182] Ann Intern Med. 2004 May 4;140(9):740-53 [15126259] Chest. 2004 Sep;126(3):761-5 [15364754] Lab Invest. 1989 Aug;61(2):235-42 [2755080] Cancer Res. 1991 Jan 15;51(2):644-51 [1985781] Diagn Cytopathol. 1990;6(5):317-22 [2292218] Cytometry. 1991;12(7):614-21 [1723676] Am J Pathol. 1993 Jan;142(1):307-17 [7678720] Cancer Res. 1994 Apr 1;54(7):1801-6 [8137295] Int J Cancer. 1994 Jun 15;57(6):781-5 [8206672] Cancer Res. 1995 Nov 1;55(21):5030-7 [7585547] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):479-84 [8552665] Genes Chromosomes Cancer. 1996 Jun;16(2):106-12 [8818657] Chest. 1997 Jun;111(6):1691-6 [9187195] Chest. 1997 Jun;111(6):1710-7 [9187198] Cancer Res. 1997 Jun 15;57(12):2331-5 [9192802] Clin Imaging. 1998 Jan-Feb;22(1):7-10 [9421648] Genes Chromosomes Cancer. 1998 May;22(1):79-82 [9591638] Lancet. 1999 Jul 10;354(9173):99-105 [10408484] Clin Cancer Res. 2004 Dec 1;10(23):7820-6 [15585613] Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30 [15983384] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Cancer Res. 2000 Apr 1;60(7):1968-73 [10766187] Am J Pathol. 2000 Aug;157(2):689 [10934171] Cancer Genet Cytogenet. 2001 Mar;125(2):87-99 [11369051] Genes Chromosomes Cancer. 2001 Jul;31(3):282-7 [11391799] Cancer. 2001 Dec 25;93(6):364-75 [11748576] Ann Thorac Surg. 2001 Dec;72(6):1861-7 [11789761] Am J Respir Crit Care Med. 2002 Feb 15;165(4):508-13 [11850344] Oncogene. 2002 Oct 7;21(45):6877-83 [12362270] Cancer. 2002 Oct 25;96(5):306-15 [12378599] Radiology. 2003 Mar;226(3):756-61 [12601181] J Mol Diagn. 2003 May;5(2):103-12 [12707375] Nat Genet. 2003 Aug;34(4):369-76 [12923544] Am J Pathol. 2003 Oct;163(4):1405-16 [14507648] Chest. 2005 Aug;128(2):906-11 [16100185] Radiology. 2006 May;239(2):586-90 [16641357] Br J Cancer. 2006 Aug 7;95(3):331-8 [16847471] N Engl J Med. 2006 Oct 26;355(17):1763-71 [17065637] Cancer. 2007 Aug 25;111(4):252-8 [17614298] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-5242 ER - TY - JOUR T1 - Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy. AN - 69791093; 19010904 AB - Interleukin-13 (IL-13) receptor alpha2 (IL-13Ralpha2), a high-affinity IL-13 binding subunit and a tumor antigen, is amplified in a variety of human tumor cell lines and tumors in vivo. By cDNA microarray, we have shown that gene transfer of human and rat adrenomedullin (AM) up-regulates IL-13Ralpha2 in a human prostate tumor cell line. Here, we show that IL-13Ralpha2 mRNA and protein are also up-regulated in PC-3 prostate tumor cells by recombinant AM (rAM) and human synthetic AM peptide in a dose-dependent manner in vitro and in vivo in mouse prostate tumor model. The 8- to 10-fold up-regulation of IL-13Ralpha2 by rAM or AM peptide in prostate tumor cells in vitro and in vivo increased their sensitivity to IL-13PE cytotoxin consisting of IL-13 and a truncated form of Pseudomonas exotoxin. Immunodeficient mice with established prostate tumors transfected with AM or treated with AM peptide showed reduction in tumor size by intratumoral administration of IL-13PE in a dose-dependent manner. At the highest dose (three 100 mug/kg/d every alternate day), >70% reduction of tumor size was observed compared with controls (P or =48 g of alcohol per day. AN - 69826321; 18715278 AB - The precise pathway by which alcohol causes the characteristic features of fetal alcohol spectrum disorders is unknown. Proposed mechanisms for fetal injury from maternal alcohol use include cellular damage from oxidative stress and impaired fetal oxygenation related to maternal systemic vasoconstriction. Our objective was to compare the levels of urinary markers of oxidative stress and systemic vasoconstriction between women consuming large amounts of alcohol during pregnancy and women who did not drink alcohol during pregnancy. Pregnant women consuming > or =48 g alcohol per day (n = 29) on average and pregnant women who abstained from alcohol use (n = 39) were identified using detailed interviews and home visits. Random maternal urine specimens were collected. Urinary levels of the oxidative stress marker, 8-isoprostane F2alpha, and of the vasoactive prostaglandin metabolites, 2,3-dinor-6-keto-prostaglandin F1alpha (a vasodilator) and 11-dehydro-thromboxane B2 (a vasoconstrictor), were measured using mass spectrometric methods. All analyte levels were corrected for urinary creatinine. In crude analyses, there was no significant difference in 8-isoprostane F2alpha between pregnant drinkers and nondrinkers (2.16 vs. 2.08 ng/mg creatinine, respectively, p = 0.87). There were no significant differences between the drinking and nondrinking groups in levels of 2,3-dinor-6-keto-prostaglandin F1alpha (1.03 vs. 1.17 ng/mg creatinine, respectively, p = 0.50), 11-dehydro-thromboxane B2 (0.72 vs. 0.59 ng/mg creatinine, respectively, p = 0.21), or the ratio of vasodilatory metabolite to vasoconstrictive metabolite (1.73 vs. 2.72, respectively, p = 0.14). Adjusting for maternal age, marital status, smoking, and gestational age at sampling did not substantially alter the results. Our results show no difference in levels of urinary eicosanoid markers of oxidative stress and systemic vasoconstriction between pregnant women who drink heavily and pregnant women who abstain. These findings speak against a role for maternal oxidative stress or systemic vasoconstriction in the pathogenesis of alcohol damage to the fetus. JF - Alcoholism, clinical and experimental research AU - Signore, Caroline AU - Aros, Sofía AU - Morrow, Jason D AU - Troendle, James AU - Conley, Mary R AU - Flanigan, Elizabeth Y AU - Cassorla, Fernando AU - Mills, James L AD - Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1893 EP - 1898 VL - 32 IS - 11 KW - Central Nervous System Depressants KW - 0 KW - Eicosanoids KW - Isoprostanes KW - 8-epi-prostaglandin F2alpha KW - 27415-26-5 KW - Ethanol KW - 3K9958V90M KW - Thromboxane B2 KW - 54397-85-2 KW - 6-Ketoprostaglandin F1 alpha KW - 58962-34-8 KW - 2,3-dinor-6-ketoprostaglandin F1alpha KW - 64700-71-6 KW - 11-dehydro-thromboxane B2 KW - 67910-12-7 KW - Dinoprost KW - B7IN85G1HY KW - Index Medicus KW - Young Adult KW - Humans KW - 6-Ketoprostaglandin F1 alpha -- urine KW - Pregnancy KW - Dinoprost -- urine KW - Ethanol -- adverse effects KW - Thromboxane B2 -- analogs & derivatives KW - Central Nervous System Depressants -- adverse effects KW - Adult KW - Cohort Studies KW - Case-Control Studies KW - Thromboxane B2 -- urine KW - Dinoprost -- analogs & derivatives KW - Follow-Up Studies KW - Adolescent KW - 6-Ketoprostaglandin F1 alpha -- analogs & derivatives KW - Female KW - Vasoconstriction -- physiology KW - Oxidative Stress -- physiology KW - Fetal Alcohol Spectrum Disorders -- physiopathology KW - Alcohol Drinking -- physiopathology KW - Alcohol Drinking -- adverse effects KW - Isoprostanes -- urine KW - Fetal Alcohol Spectrum Disorders -- etiology KW - Eicosanoids -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69826321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Markers+of+oxidative+stress+and+systemic+vasoconstriction+in+pregnant+women+drinking+%26gt%3B+or+%3D48+g+of+alcohol+per+day.&rft.au=Signore%2C+Caroline%3BAros%2C+Sof%C3%ADa%3BMorrow%2C+Jason+D%3BTroendle%2C+James%3BConley%2C+Mary+R%3BFlanigan%2C+Elizabeth+Y%3BCassorla%2C+Fernando%3BMills%2C+James+L&rft.aulast=Signore&rft.aufirst=Caroline&rft.date=2008-11-01&rft.volume=32&rft.issue=11&rft.spage=1893&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/10.1111%2Fj.1530-0277.2008.00773.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-09 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hypertension. 2000 Jun;35(6):1307-13 [10856282] FASEB J. 2000 Jul;14(10):1289-96 [10877821] J Matern Fetal Med. 2000 May-Jun;9(3):173-7 [10914626] Pediatrics. 2000 Aug;106(2 Pt 1):358-61 [10920168] Alcohol. 2000 Jun;21(2):169-80 [10963940] Eur J Obstet Gynecol Reprod Biol. 2000 Nov;93(1):65-9 [11000507] MMWR Morb Mortal Wkly Rep. 2002 Apr 5;51(13):273-6 [11952279] MMWR Morb Mortal Wkly Rep. 2002 May 24;51(20):433-5 [12056499] Mol Aspects Med. 2002 Feb-Jun;23(1-3):101-208 [12079771] Trends Pharmacol Sci. 2002 Aug;23(8):360-6 [12377577] Circulation. 2002 Nov 12;106(20):2543-9 [12427649] Neurotoxicol Teratol. 2003 Jan-Feb;25(1):1-9 [12633732] Am J Obstet Gynecol. 2003 Apr;188(4):986-92 [12712098] Free Radic Res. 2004 Feb;38(2):105-22 [15104204] Best Pract Res Clin Obstet Gynaecol. 2004 Jun;18(3):383-96 [15183134] Lancet. 1973 Jun 9;1(7815):1267-71 [4126070] Am J Obstet Gynecol. 1983 Mar 15;145(6):730-2 [6338724] Obstet Gynecol. 1984 May;63(5):677-80 [6546976] Life Sci. 1987 Jul 20;41(3):371-6 [3110528] Obstet Gynecol. 1988 Jan;71(1):61-6 [3275910] J Dev Physiol. 1989 Mar;11(3):179-84 [2530267] J Chromatogr. 1993 Feb 26;612(2):179-85 [8468374] Am J Obstet Gynecol. 1993 Oct;169(4):1007-12 [8238110] J Chromatogr B Biomed Appl. 1994 Mar 4;653(2):117-22 [8205238] Mol Cell Biochem. 1994 Nov 9;140(1):85-9 [7877602] Metab Brain Dis. 1994 Dec;9(4):291-322 [7898398] Adv Exp Med Biol. 1994;366:291-305 [7771260] Alcohol Clin Exp Res. 1995 Jun;19(3):741-6 [7573802] Placenta. 1995 Sep;16(6):503-15 [8570572] Circulation. 1996 Jul 1;94(1):19-25 [8964113] Free Radic Biol Med. 1996;20(4):619-24 [8904305] Prog Lipid Res. 1997 Mar;36(1):1-21 [9373618] Methods Enzymol. 1999;300:3-12 [9919502] Am J Obstet Gynecol. 1999 Nov;181(5 Pt 1):1211-5 [10561647] Free Radic Biol Med. 2000 Feb 15;28(4):505-13 [10719231] Drug Metab Rev. 1999 Feb;31(1):117-39 [10065368] JAMA. 1999 Jul 28;282(4):356-62 [10432033] J Clin Invest. 1999 Sep;104(6):805-13 [10491416] Free Radic Biol Med. 2005 Mar 15;38(6):698-710 [15721980] Lancet. 2005 Feb 26-Mar 4;365(9461):785-99 [15733721] Arch Surg. 2005 Aug;140(8):801-7 [16103291] J Soc Gynecol Investig. 2006 Feb;13(2):118-21 [16443505] Subst Use Misuse. 2006;41(2):183-97 [16479683] Curr Pharm Des. 2006;12(8):895-902 [16533158] Clin Lab Med. 2006 Sep;26(3):571-90, v-vi [16938585] Curr Med Chem. 2007;14(6):703-17 [17346157] Methods Enzymol. 2007;433:113-26 [17954231] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1530-0277.2008.00773.x ER - TY - JOUR T1 - Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. AN - 69825858; 19023402 AB - The major DNA repair pathways operate on damage in double-strand DNA because they use the intact strand as a template after damage removal. Therefore, lesions in transient single-strand stretches of chromosomal DNA are expected to be especially threatening to genome stability. To test this hypothesis, we designed systems in budding yeast that could generate many kilobases of persistent single-strand DNA next to double-strand breaks or uncapped telomeres. The systems allowed controlled restoration to the double-strand state after applying DNA damage. We found that lesions induced by UV-light and methyl methanesulfonate can be tolerated in long single-strand regions and are hypermutagenic. The hypermutability required PCNA monoubiquitination and was largely attributable to translesion synthesis by the error-prone DNA polymerase zeta. In support of multiple lesions in single-strand DNA being a source of hypermutability, analysis of the UV-induced mutants revealed strong strand-specific bias and unexpectedly high frequency of alleles with widely separated multiple mutations scattered over several kilobases. Hypermutability and multiple mutations associated with lesions in transient stretches of long single-strand DNA may be a source of carcinogenesis and provide selective advantage in adaptive evolution. JF - PLoS genetics AU - Yang, Yong AU - Sterling, Joan AU - Storici, Francesca AU - Resnick, Michael A AU - Gordenin, Dmitry A AD - Department of Health and Human Services, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1 VL - 4 IS - 11 KW - DNA, Fungal KW - 0 KW - DNA, Single-Stranded KW - Index Medicus KW - DNA Repair KW - Models, Genetic KW - Ultraviolet Rays -- adverse effects KW - DNA, Fungal -- genetics KW - Genome, Fungal KW - Mutagenesis KW - Saccharomyces cerevisiae -- genetics KW - Telomere -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - DNA, Single-Stranded -- chemistry KW - DNA Breaks, Double-Stranded -- radiation effects KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69825858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+genetics&rft.atitle=Hypermutability+of+damaged+single-strand+DNA+formed+at+double-strand+breaks+and+uncapped+telomeres+in+yeast+Saccharomyces+cerevisiae.&rft.au=Yang%2C+Yong%3BSterling%2C+Joan%3BStorici%2C+Francesca%3BResnick%2C+Michael+A%3BGordenin%2C+Dmitry+A&rft.aulast=Yang&rft.aufirst=Yong&rft.date=2008-11-01&rft.volume=4&rft.issue=11&rft.spage=e1000264&rft.isbn=&rft.btitle=&rft.title=PLoS+genetics&rft.issn=1553-7404&rft_id=info:doi/10.1371%2Fjournal.pgen.1000264 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Mol Cell Biol. 2005 Dec;6(12):943-53 [16341080] Genes Dev. 2008 Jan 15;22(2):125-40 [18198332] DNA Repair (Amst). 2006 Feb 3;5(2):258-73 [16310415] J Cell Biol. 2006 Apr 24;173(2):195-206 [16618811] Methods Enzymol. 2006;409:329-45 [16793410] Methods Enzymol. 2006;409:462-76 [16793418] Nat Rev Immunol. 2006 Aug;6(8):573-83 [16868548] EMBO J. 2006 Sep 20;25(18):4316-25 [16957771] Mol Cell Biol. 2006 Oct;26(20):7645-57 [16908537] Annu Rev Genet. 2006;40:209-35 [16805667] Nat Struct Mol Biol. 2007 Mar;14(3):208-14 [17293872] Genetics. 2007 Mar;175(3):1533-7 [17151233] Proc Natl Acad Sci U S A. 2007 May 15;104(20):8403-8 [17485671] Crit Rev Biochem Mol Biol. 2007 Jul-Aug;42(4):247-58 [17687667] Crit Rev Biochem Mol Biol. 2007 Sep-Oct;42(5):313-26 [17917869] Nat Biotechnol. 2001 Aug;19(8):773-6 [11479573] Curr Opin Microbiol. 2001 Oct;4(5):582-5 [11587936] Nucleic Acids Res. 2001 Nov 1;29(21):4414-22 [11691929] Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1437-42 [11818556] Genetics. 2002 Nov;162(3):1063-77 [12454056] DNA Repair (Amst). 2002 Jun 21;1(6):425-35 [12509231] Nat Genet. 2003 Jul;34(3):326-9 [12796780] Nucleic Acids Res. 2003 Aug 1;31(15):4541-52 [12888515] J Cell Sci. 2003 Oct 15;116(Pt 20):4057-65 [12972499] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14994-9 [14630945] J Bacteriol. 1972 Mar;109(3):979-86 [4551759] Mutat Res. 1975 Nov;30(2):209-18 [1107831] Nature. 1979 Aug 2;280(5721):420-3 [223063] Crit Rev Microbiol. 1985;12(2):131-51 [3928261] Cancer Res. 1991 Jun 15;51(12):3075-9 [2039987] Genetics. 1991 Nov;129(3):957-62 [1752431] Genetics. 1995 Jul;140(3):965-72 [7672595] Yeast. 1995 Dec;11(16):1553-73 [8720065] Photochem Photobiol. 1997 Feb;65(2):270-83 [9066304] J Mol Biol. 1999 Jun 25;289(5):1207-18 [10373362] Yeast. 1999 Oct;15(14):1541-53 [10514571] Proc Natl Acad Sci U S A. 1963 Nov;50:975-80 [14082365] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12849-54 [16118275] Biochem Soc Trans. 2007 Nov;35(Pt 5):1334-7 [17956345] DNA Repair (Amst). 2007 Dec 1;6(12):1829-38 [17715002] Nature. 2007 Nov 22;450(7169):509-14 [17965729] Mol Cell. 2007 Dec 14;28(5):739-45 [18082599] Mol Cell. 2006 Jan 6;21(1):15-27 [16387650] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pgen.1000264 ER - TY - JOUR T1 - One-carbon metabolism biomarkers and risk of colon and rectal cancers. AN - 69764171; 18990766 AB - Folate intake has been associated with reduced colorectal cancer risk; however, few studies have prospectively examined circulating folate or other related one-carbon biomarkers. We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of 50- to 69-year-old Finnish men to investigate associations between serum folate, vitamin B6, vitamin B12, riboflavin, and homocysteine and risk of colon and rectal cancers. Controls were alive and cancer-free at the time of case diagnosis and matched 1:1 on age and date of baseline fasting serum collection with cases (152 colon and 126 rectal cancers). Multivariate-adjusted odds ratios and 95% confidence intervals were calculated using conditional logistic regression. Serum vitamin B6 was inversely associated with colon cancer [odds ratio, 0.30 (95% confidence interval, 0.11-0.82) in the highest versus lowest quintile]. An increased risk of colon cancer was suggested for men in the middle quintile of serum folate, but without indication of a dose-response relationship. None of the other serum biomarkers were associated with colon or rectal cancer, and we observed no interactions with alcohol consumption or methionine or protein intake. A priori combinations of the five one-carbon serum biomarkers provided no clear evidence to support a collective influence on colorectal cancer risk. Our results support the hypothesis that higher vitamin B6 status may play a role in inhibiting colon cancer carcinogenesis; however, folate and other one-carbon related biomarkers were not associated with colon or rectal cancer. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Weinstein, Stephanie J AU - Albanes, Demetrius AU - Selhub, Jacob AU - Graubard, Barry AU - Lim, Unhee AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Stolzenberg-Solomon, Rachael AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Nutritional Epidemiology Branch, Suite 320, 6120 Executive Boulevard, Bethesda, MD 20892, USA. weinstes@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 3233 EP - 3240 VL - 17 IS - 11 SN - 1055-9965, 1055-9965 KW - Biomarkers, Tumor KW - 0 KW - Placebos KW - Vitamin B 6 KW - 8059-24-3 KW - Folic Acid KW - 935E97BOY8 KW - Index Medicus KW - Double-Blind Method KW - Chi-Square Distribution KW - Folic Acid -- blood KW - Humans KW - Aged KW - Risk KW - Primary Prevention KW - Logistic Models KW - Risk Factors KW - Case-Control Studies KW - Middle Aged KW - Finland -- epidemiology KW - Male KW - Vitamin B 6 -- blood KW - Colorectal Neoplasms -- blood KW - Colorectal Neoplasms -- epidemiology KW - Biomarkers, Tumor -- blood KW - Colorectal Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69764171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=One-carbon+metabolism+biomarkers+and+risk+of+colon+and+rectal+cancers.&rft.au=Weinstein%2C+Stephanie+J%3BAlbanes%2C+Demetrius%3BSelhub%2C+Jacob%3BGraubard%2C+Barry%3BLim%2C+Unhee%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BStolzenberg-Solomon%2C+Rachael&rft.aulast=Weinstein&rft.aufirst=Stephanie&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=3233&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0459 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):403-12 [10794485] Cancer Epidemiol Biomarkers Prev. 1999 Sep;8(9):825-9 [10498402] J Nutr. 2001 Aug;131(8):2204-7 [11481418] J Nutr. 2002 Feb;132(2):283-8 [11823591] J Nutr. 2002 Aug;132(8 Suppl):2350S-2355S [12163691] J Nutr. 2002 Aug;132(8 Suppl):2413S-2418S [12163703] Cancer Causes Control. 2002 Aug;13(6):551-61 [12195645] Int J Cancer. 2002 Oct 10;101(5):403-8 [12216066] Acta Oncol. 2002;41(4):381-8 [12234031] Nutr Cancer. 2002;43(2):152-8 [12588695] Nicotine Tob Res. 2003 Jun;5(3):357-62 [12791531] J Nutr Biochem. 2003 May;14(5):246-50 [12832027] Int J Cancer. 2004 Jan 20;108(3):433-42 [14648711] J Nutr. 2004 Mar;134(3):489-92 [14988435] Annu Rev Med. 1982;33:345-54 [6805415] Am J Epidemiol. 1986 Jul;124(1):17-27 [3521261] Adv Exp Med Biol. 1986;206:313-30 [3591525] J Chromatogr. 1987 Nov 27;422:43-52 [3437026] Am J Epidemiol. 1988 Sep;128(3):655-66 [2458036] Int J Epidemiol. 1991 Jun;20(2):368-74 [1917236] Int J Vitam Nutr Res. 1992;62(2):165-72 [1517040] Nutr Rev. 1993 Aug;51(8):217-25 [8302491] Ann Epidemiol. 1994 Jan;4(1):1-10 [8205268] Am J Clin Nutr. 1994 Oct;60(4):559-66 [8092091] J Natl Cancer Inst. 1995 Feb 15;87(4):265-73 [7707417] Mol Nutr Food Res. 2007 Mar;51(3):267-92 [17295418] JAMA. 2007 Jun 6;297(21):2351-9 [17551129] JAMA. 2007 Jun 6;297(21):2408-9 [17551134] J Nutr. 2007 Jul;137(7):1808-14 [17585035] Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1325-9 [17626997] Cancer Causes Control. 2008 Feb;19(1):67-74 [17943453] Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):171-82 [18199722] Int J Cancer. 2008 May 1;122(9):2057-61 [18092327] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Cancer Epidemiol Biomarkers Prev. 1996 Jul;5(7):487-94 [8827351] Cancer Res. 1997 Mar 15;57(6):1098-102 [9067278] Br J Cancer. 1999 Apr;79(11-12):1917-22 [10206314] J Nutr. 1999 Apr;129(4):779-82 [10203550] Int J Cancer. 2005 Feb 20;113(5):825-8 [15499620] J Natl Cancer Inst. 2005 May 4;97(9):684-92 [15870439] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1198-203 [15894672] Gastroenterology. 2005 Jun;128(7):1830-7 [15940618] Am J Epidemiol. 2006 Jan 15;163(2):108-15 [16339055] Ann Epidemiol. 2006 Mar;16(3):206-12 [16343942] Gut. 2006 Oct;55(10):1461-6 [16638790] Clin Chim Acta. 2007 Feb;377(1-2):14-38 [17045981] Annu Rev Nutr. 1999;19:217-46 [10448523] Ann Epidemiol. 2001 Jan;11(1):65-72 [11164122] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0459 ER - TY - JOUR T1 - Menopausal hormone therapy and breast cancer risk in the NIH-AARP Diet and Health Study Cohort. AN - 69761148; 18990757 AB - Results from the Women's Health Initiative trial raise new questions regarding the effects of estrogen therapy (ET) and estrogen plus progestin therapy (EPT) on breast cancer risk. We analyzed data from 126,638 females, ages 50 to 71 years at baseline, who completed two questionnaires (1995--1996 and 1996--1997) as part of the NIH-AARP Diet and Health Cohort Study and in whom 3,657 incident breast cancers were identified through June 30, 2002. Hormone-associated relative risks (RR) and 95% confidence intervals (CI) of breast cancer were estimated via multivariable regression models. Among thin women (body mass index or = 10 years) users (RR, 2.44; 95% CI, 2.13-2.79). These risks were slightly higher when progestins were prescribed continuously than sequentially (< 15 days/mo; respective RRs of 2.76 versus 2.01). EPT associations were strongest in thin women, but elevated risks persisted among heavy women. EPT use was strongly related to estrogen receptor (ER)-positive tumors, requiring consideration of this variable when assessing relationships according to other clinical features. For instance, ER- ductal tumors were unaffected by EPT use, but all histologic subgroups of ER+ tumors were increased, especially low-grade and mixed ductal-lobular tumors. Both ET and EPT were associated with breast cancer risks with the magnitude of increase varying according to body mass and clinical characteristics of the tumors. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Brinton, Louise A AU - Richesson, Douglas AU - Leitzmann, Michael F AU - Gierach, Gretchen L AU - Schatzkin, Arthur AU - Mouw, Traci AU - Hollenbeck, Albert R AU - Lacey, James V AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA. brinton@nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 3150 EP - 3160 VL - 17 IS - 11 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Prospective Studies KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Incidence KW - Aged KW - Middle Aged KW - Diet KW - United States -- epidemiology KW - Menopause KW - Female KW - Proportional Hazards Models KW - Estrogen Replacement Therapy -- adverse effects KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69761148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Menopausal+hormone+therapy+and+breast+cancer+risk+in+the+NIH-AARP+Diet+and+Health+Study+Cohort.&rft.au=Brinton%2C+Louise+A%3BRichesson%2C+Douglas%3BLeitzmann%2C+Michael+F%3BGierach%2C+Gretchen+L%3BSchatzkin%2C+Arthur%3BMouw%2C+Traci%3BHollenbeck%2C+Albert+R%3BLacey%2C+James+V&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=3150&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0435 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Jan 26;283(4):485-91 [10659874] JAMA. 1999 Jun 9;281(22):2091-7 [10367819] Am J Epidemiol. 2000 Feb 15;151(4):404-8 [10695599] Cancer. 2000 Jun 1;88(11):2570-7 [10861435] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] J Clin Oncol. 2002 Feb 1;20(3):699-706 [11821451] JAMA. 2002 Feb 13;287(6):734-41 [11851540] Cancer Epidemiol Biomarkers Prev. 2002 Jul;11(7):593-600 [12101105] JAMA. 2004 Jan 7;291(1):47-53 [14709575] Cancer Causes Control. 2003 Dec;14(10):933-43 [14750532] Hum Reprod. 2004 Mar;19(3):741-56 [14998980] Int J Cancer. 2004 May 1;109(5):721-7 [14999781] JAMA. 2004 Apr 14;291(14):1701-12 [15082697] Cancer. 2004 Jun 1;100(11):2328-37 [15160335] Br J Cancer. 2004 Aug 16;91(4):644-50 [15238982] Int J Cancer. 2004 Oct 20;112(1):130-4 [15305384] Cancer. 2004 Oct 1;101(7):1490-500 [15378477] Ann Intern Med. 1992 Dec 15;117(12):1016-37 [1443971] N Engl J Med. 1995 Jun 15;332(24):1589-93 [7753136] Am J Epidemiol. 1998 Apr 15;147(8):718-21 [9554412] Int J Cancer. 1999 May 5;81(3):339-44 [10209946] Clin Cancer Res. 2005 Jan 15;11(2 Pt 2):909s-17s [15701886] Br J Cancer. 2005 Apr 11;92(7):1293-7 [15785751] Int J Cancer. 2006 Mar 1;118(5):1285-91 [16170777] Am J Med. 2005 Dec 19;118 Suppl 12B:64-73 [16414329] Breast Cancer Res. 2006;8(1):R11 [16507159] Arch Intern Med. 2006 Apr 10;166(7):760-5 [16606813] JAMA. 2006 Apr 12;295(14):1647-57 [16609086] Arch Intern Med. 2006 May 8;166(9):1027-32 [16682578] Br J Cancer. 2006 Jul 3;95(1):123-9 [16755295] Lancet Oncol. 2006 Nov;7(11):910-8 [17081916] Am J Epidemiol. 2007 Mar 1;165(5):524-9 [17132697] N Engl J Med. 2007 Apr 19;356(16):1670-4 [17442911] J Natl Cancer Inst. 2007 Aug 1;99(15):1152-61 [17652280] Am J Obstet Gynecol. 2008 Jan;198(1):34.e1-7 [17981254] Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):43-50 [18199710] J Clin Oncol. 2008 Mar 10;26(8):1260-8 [18323549] Am J Epidemiol. 2008 Jun 15;167(12):1407-15 [18448442] JAMA. 2002 Jul 17;288(3):321-33 [12117397] South Med J. 2002 Aug;95(8):795-7 [12190211] Cancer Causes Control. 2002 Aug;13(6):583-90 [12195648] JAMA. 2002 Oct 9;288(14):1723-7 [12365955] Cancer Causes Control. 2002 Nov;13(9):847-54 [12462550] Cancer. 2002 Dec 15;95(12):2455-64 [12467057] Obstet Gynecol. 2002 Dec;100(6):1148-58 [12468157] Cancer. 2003 Mar 15;97(6):1387-92 [12627501] Cancer Causes Control. 2003 Apr;14(3):225-33 [12814201] JAMA. 2003 Jun 25;289(24):3243-53 [12824205] JAMA. 2003 Jun 25;289(24):3254-63 [12824206] Lancet. 2003 Aug 9;362(9382):419-27 [12927427] Cancer Causes Control. 2003 Sep;14(7):673-80 [14575365] Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1175-81 [14652277] Lancet. 1997 Oct 11;350(9084):1047-59 [10213546] J Natl Cancer Inst. 2000 Feb 16;92(4):328-32 [10675382] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0435 ER - TY - JOUR T1 - Hematopoietic malignancies associated with viral and alcoholic hepatitis. AN - 69757629; 18957521 AB - Hepatitis C virus (HCV) and hepatitis B virus (HBV) have been associated with hematopoietic malignancies, but data for many subtypes are limited. From the U.S. Surveillance, Epidemiology, and End Results-Medicare database, we selected 61,464 cases (> or = 67 years) with hematopoietic malignancies and 122,531 population-based controls, frequency-matched by gender, age, and year (1993--2002). Logistic regression was used to compare the prevalence of HCV, HBV, and alcoholic hepatitis in cases and controls, adjusted for matching factors, race, duration of Medicare coverage, and number of physician claims. HCV, HBV, and alcoholic hepatitis were reported in 195 (0.3%), 111 (0.2%), and 404 (0.7%) cases and 264 (0.2%), 242 (0.2%), and 798 (0.7%) controls, respectively. HCV was associated with increased risk of diffuse large B-cell lymphoma [odds ratio (OR) 1.52, 95% confidence interval (95% CI) 1.05-2.18], Burkitt lymphoma (OR 5.21, 95% CI 1.62-16.8), follicular lymphoma (OR 1.88, 95% CI 1.17-3.02), marginal zone lymphoma (OR 2.20, 95% CI 1.22-3.95), and acute myeloid leukemia (OR 1.54, 95% CI 1.00-2.37). In contrast, HBV was unrelated to any hematopoietic malignancies. Alcoholic hepatitis was associated with decreased risk of non-Hodgkin lymphoma overall, but increased risk of Burkitt lymphoma. In summary, HCV, but not other causes of hepatitis, was associated with the elevated risk of non-Hodgkin lymphoma and acute myeloid leukemia. HCV may induce lymphoproliferative malignancies through chronic immune stimulation. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Anderson, Lesley A AU - Pfeiffer, Ruth AU - Warren, Joan L AU - Landgren, Ola AU - Gadalla, Shahinaz AU - Berndt, Sonja I AU - Ricker, Winnie AU - Parsons, Ruth AU - Wheeler, William AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076 Rockville, MD 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 3069 EP - 3075 VL - 17 IS - 11 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Logistic Models KW - Aged, 80 and over KW - Humans KW - SEER Program KW - Case-Control Studies KW - Aged KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Hepatitis, Alcoholic -- complications KW - Hepatitis B -- complications KW - Hematologic Neoplasms -- etiology KW - Hepatitis C -- complications KW - Hepatitis, Alcoholic -- epidemiology KW - Hematologic Neoplasms -- virology KW - Hepatitis C -- epidemiology KW - Hematologic Neoplasms -- epidemiology KW - Hepatitis B -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69757629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Hematopoietic+malignancies+associated+with+viral+and+alcoholic+hepatitis.&rft.au=Anderson%2C+Lesley+A%3BPfeiffer%2C+Ruth%3BWarren%2C+Joan+L%3BLandgren%2C+Ola%3BGadalla%2C+Shahinaz%3BBerndt%2C+Sonja+I%3BRicker%2C+Winnie%3BParsons%2C+Ruth%3BWheeler%2C+William%3BEngels%2C+Eric+A&rft.aulast=Anderson&rft.aufirst=Lesley&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=3069&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0408 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Haematol. 1999 Nov;107(2):353-6 [10583224] Blood. 2008 Apr 1;111(7):3388-94 [18239085] J Gastroenterol Hepatol. 2001 Feb;16(2):215-9 [11207904] Eur J Clin Invest. 2001 Jul;31(7):628-38 [11454019] Acta Haematol. 2001;105(4):237-40 [11528098] Liver. 2001 Oct;21(5):335-41 [11589770] Jpn J Cancer Res. 2002 May;93(5):471-7 [12036441] Alcohol. 2002 May;27(1):17-21 [12062632] N Engl J Med. 2002 Jul 11;347(2):89-94 [12110736] Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S50-3 [12142963] Med Care. 2002 Aug;40(8 Suppl):IV-3-18 [12187163] Hematol J. 2003;4(5):303-9 [14502253] J Med Microbiol. 2004 Jan;53(Pt 1):21-9 [14663101] Haematologica. 2004 Jan;89(1):70-6 [14754608] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):425-30 [15006919] Med Oncol. 2004;21(1):67-72 [15034216] Int J Cancer. 2004 Aug 10;111(1):81-5 [15185347] Cancer Sci. 2004 Sep;95(9):745-52 [15471561] Gastroenterology. 1991 Jan;100(1):182-8 [1983820] Haematologica. 1996 Mar-Apr;81(2):162-4 [8641648] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):227-30 [8833624] Hum Pathol. 1997 Jan;28(1):101-4 [9013840] Arch Virol. 1997;142(3):545-55 [9349300] Blood. 1998 Nov 1;92(9):3328-37 [9787170] Science. 1998 Oct 30;282(5390):938-41 [9794763] Am J Public Health. 1999 Jan;89(1):14-8 [9987458] Leuk Lymphoma. 1999 Jun;34(1-2):45-52 [10350331] Br J Cancer. 1999 Jul;80(9):1476-82 [10424754] Eur J Haematol. 2005 Feb;74(2):158-65 [15654908] Hepatology. 2005 Mar;41(3):652-9 [15723449] Expert Opin Drug Saf. 2005 May;4(3):599-608 [15934864] Clin Gastroenterol Hepatol. 2008 Apr;6(4):451-8 [18387498] Lancet Oncol. 2005 Jul;6(7):469-76 [15992695] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18544-9 [16339892] Haematologica. 2006 Apr;91(4):554-7 [16585021] J Hepatol. 2006 Aug;45(2):197-203 [16684579] AIDS. 2006 Aug 1;20(12):1645-54 [16868446] Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2078-85 [17119031] Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):401-4 [17337646] Cancer. 2007 Apr 1;109(7):1360-4 [17326056] JAMA. 2007 May 9;297(18):2010-7 [17488966] Blood. 2007 Jul 15;110(2):695-708 [17389762] Hepatology. 2007 Jul;46(1):107-12 [17526021] Eur J Haematol. 2007 Aug;79(2):132-7 [17635237] Br J Haematol. 2007 Dec;139(5):791-8 [17941950] J Hepatol. 1999;31 Suppl 1:88-91 [10622567] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0408 ER - TY - JOUR T1 - Endogenous retroviruses--aiding and abetting genomic plasticity. AN - 69755136; 18818876 JF - Cellular and molecular life sciences : CMLS AU - Eiden, M V AD - National Institutes of Health, Bethesda, Maryland 20892, USA. eidenm@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 3325 EP - 3328 VL - 65 IS - 21 KW - Index Medicus KW - Animals KW - Humans KW - Cell Transformation, Viral -- genetics KW - Proviruses -- genetics KW - Germ Cells -- virology KW - Vertebrates -- virology KW - Virus Integration KW - Mutagenesis, Insertional KW - Evolution, Molecular KW - Host-Pathogen Interactions -- genetics KW - Endogenous Retroviruses -- physiology KW - Host-Pathogen Interactions -- physiology KW - Endogenous Retroviruses -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69755136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.atitle=Endogenous+retroviruses--aiding+and+abetting+genomic+plasticity.&rft.au=Eiden%2C+M+V&rft.aulast=Eiden&rft.aufirst=M&rft.date=2008-11-01&rft.volume=65&rft.issue=21&rft.spage=3325&rft.isbn=&rft.btitle=&rft.title=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.issn=1420-9071&rft_id=info:doi/10.1007%2Fs00018-008-8493-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-19 N1 - Date created - 2008-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Feb 17;403(6771):785-9 [10693809] Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17506-11 [17959780] J Virol. 2000 May;74(9):4264-72 [10756041] J Biol Chem. 2001 Jan 19;276(3):1896-903 [11054415] J Gen Virol. 1971 Feb;10(2):195-8 [4324256] Nat New Biol. 1972 Feb 9;235(58):170-1 [4501200] Genes Dev. 1992 Aug;6(8):1457-65 [1379564] Nucleic Acids Res. 1993 Jan 11;21(1):135-43 [8382789] J Virol. 2006 Mar;80(6):3104-7 [16501122] J Virol. 2006 Jun;80(11):5651-4 [16699047] Nature. 2006 Jul 6;442(7098):79-81 [16823453] Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14390-5 [16980413] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6261-5 [17384150] Cell Physiol Biochem. 2007;20(5):517-26 [17762178] J Virol. 2007 Oct;81(20):11441-51 [17699582] J Virol. 2000 Apr;74(7):3321-9 [10708449] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00018-008-8493-4 ER - TY - JOUR T1 - Genome wide transcriptional profiling in breast cancer cells reveals distinct changes in hormone receptor target genes and chromatin modifying enzymes after proteasome inhibition. AN - 69748824; 18381591 AB - Steroid hormone receptors, like glucocorticoid (GR) and estrogen receptors (ER), are master regulators of genes that control many biological processes implicated in health and disease. Gene expression is dependent on receptor levels which are tightly regulated by the ubiquitin-proteasome system. Previous studies have shown that proteasome inhibition increases GR, but decreases ER-mediated gene expression. At the gene expression level this divergent role of the proteasome in receptor-dependent transcriptional regulation is not well understood. We have used a genomic approach to examine the impact of proteasome activity on GR- and ER-mediated gene expression in MCF-7 breast cancer cells treated with dexamethasone (DEX) or 17beta-estradiol (E2), the proteasome inhibitor MG132 (MG) or MG132 and either hormone (MD or ME2) for 24 h. Transcript profiling reveals that inhibiting proteasome activity modulates gene expression by GR and ER in a similar manner in that several GR and ER target genes are upregulated and downregulated after proteasome inhibition. In addition, proteasome inhibition modulates receptor-dependent genes involved in the etiology of a number of human pathological states, including multiple myeloma, leukemia, breast/prostate cancer, HIV/AIDS, and neurodegenerative disorders. Importantly, our analysis reveals that a number of transcripts encoding histone and DNA modifying enzymes, prominently histone/DNA methyltransferases and demethylases, are altered after proteasome inhibition. As proteasome inhibitors are currently in clinical trials as therapy for multiple myeloma, HIV/AIDS and leukemia, the possibility that some of the target molecules are hormone regulated and chromatin modifying enzymes is intriguing in this era of epigenetic therapy. JF - Molecular carcinogenesis AU - Kinyamu, H Karimi AU - Collins, Jennifer B AU - Grissom, Sherry F AU - Hebbar, Pratibha B AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 845 EP - 885 VL - 47 IS - 11 KW - Chromatin KW - 0 KW - Glucocorticoids KW - Proteasome Inhibitors KW - Receptors, Estrogen KW - DNA KW - 9007-49-2 KW - RNA Polymerase II KW - EC 2.7.7.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - RNA Polymerase II -- metabolism KW - Glucocorticoids -- metabolism KW - Gene Expression Profiling KW - Proteasome Endopeptidase Complex -- metabolism KW - Humans KW - DNA -- metabolism KW - DNA -- genetics KW - Cell Line, Tumor KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Gene Expression Regulation, Neoplastic -- genetics KW - Breast Neoplasms -- genetics KW - Receptors, Estrogen -- antagonists & inhibitors KW - Chromatin -- metabolism KW - Transcription, Genetic -- drug effects KW - Genome, Human -- genetics KW - Transcription, Genetic -- genetics KW - Breast Neoplasms -- metabolism KW - Receptors, Estrogen -- metabolism KW - Chromatin -- genetics KW - Breast Neoplasms -- pathology KW - Chromatin -- drug effects KW - Breast Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69748824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Genome+wide+transcriptional+profiling+in+breast+cancer+cells+reveals+distinct+changes+in+hormone+receptor+target+genes+and+chromatin+modifying+enzymes+after+proteasome+inhibition.&rft.au=Kinyamu%2C+H+Karimi%3BCollins%2C+Jennifer+B%3BGrissom%2C+Sherry+F%3BHebbar%2C+Pratibha+B%3BArcher%2C+Trevor+K&rft.aulast=Kinyamu&rft.aufirst=H&rft.date=2008-11-01&rft.volume=47&rft.issue=11&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20440 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20440 ER - TY - JOUR T1 - Personal accounts: could Noah's life have been saved? Confronting dual diagnosis and a fragmented mental health system. AN - 69738573; 18971400 JF - Psychiatric services (Washington, D.C.) AU - Seidenberg, Gordon R AD - Division of AIDS and Health and Behavior Research, National Institute of Mental Health. gseidenberg@hotmail.com Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1254 EP - 1255 VL - 59 IS - 11 KW - Index Medicus KW - Young Adult KW - Humans KW - Substance-Related Disorders KW - Mental Health Services KW - Anecdotes as Topic KW - Male KW - Comorbidity KW - Quality of Health Care KW - Diagnosis, Dual (Psychiatry) KW - Suicide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69738573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Personal+accounts%3A+could+Noah%27s+life+have+been+saved%3F+Confronting+dual+diagnosis+and+a+fragmented+mental+health+system.&rft.au=Seidenberg%2C+Gordon+R&rft.aulast=Seidenberg&rft.aufirst=Gordon&rft.date=2008-11-01&rft.volume=59&rft.issue=11&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=1557-9700&rft_id=info:doi/10.1176%2Fappi.ps.59.11.1254 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-27 N1 - Date created - 2008-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1176/appi.ps.59.11.1254 ER - TY - JOUR T1 - Routine diagnostic X-ray examinations and increased frequency of chromosome translocations among U.S. radiologic technologists. AN - 69732606; 18974125 AB - The U.S. population has nearly one radiographic examination per person per year, and concern about cancer risks associated with medical radiation has increased. Radiologic technologists were surveyed to determine whether their personal cumulative exposure to diagnostic X-rays was associated with increased frequencies of chromosome translocations, an established radiation biomarker and possible intermediary suggesting increased cancer risk. Within a large cohort of U.S. radiologic technologists, 150 provided a blood sample for whole chromosome painting and were interviewed about past X-ray examinations. The number and types of examinations reported were converted to a red bone marrow (RBM) dose score with units that approximated 1 mGy. The relationship between dose score and chromosome translocation frequency was assessed using Poisson regression. The estimated mean cumulative RBM radiation dose score was 49 (range, 0-303). After adjustment for age, translocation frequencies significantly increased with increasing RBM dose score with an estimate of 0.004 translocations per 100 cell equivalents per score unit (95% confidence interval, 0.002-0.007; P < 0.001). Removing extreme values or adjustment for gender, cigarette smoking, occupational radiation dose, allowing practice X-rays while training, work with radioisotopes, and radiotherapy for benign conditions did not affect the estimate. Cumulative radiation exposure from routine X-ray examinations was associated independently with increased chromosome damage, suggesting the possibility of elevated long-term health risks, including cancer. The slope estimate was consistent with expectation based on cytogenetic experience and atomic bomb survivor data. JF - Cancer research AU - Sigurdson, Alice J AU - Bhatti, Parveen AU - Preston, Dale L AU - Doody, Michele Morin AU - Kampa, Diane AU - Alexander, Bruce H AU - Petibone, Dayton AU - Yong, Lee C AU - Edwards, Alan A AU - Ron, Elaine AU - Tucker, James D AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. sigurdsa@mail.nih.gov Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 8825 EP - 8831 VL - 68 IS - 21 KW - Index Medicus KW - United States KW - Aged, 80 and over KW - Humans KW - Cohort Studies KW - In Situ Hybridization, Fluorescence KW - Aged KW - Dose-Response Relationship, Radiation KW - Male KW - Female KW - Occupational Exposure KW - Technology, Radiologic -- manpower KW - Translocation, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69732606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Routine+diagnostic+X-ray+examinations+and+increased+frequency+of+chromosome+translocations+among+U.S.+radiologic+technologists.&rft.au=Sigurdson%2C+Alice+J%3BBhatti%2C+Parveen%3BPreston%2C+Dale+L%3BDoody%2C+Michele+Morin%3BKampa%2C+Diane%3BAlexander%2C+Bruce+H%3BPetibone%2C+Dayton%3BYong%2C+Lee+C%3BEdwards%2C+Alan+A%3BRon%2C+Elaine%3BTucker%2C+James+D&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2008-11-01&rft.volume=68&rft.issue=21&rft.spage=8825&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1691 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-08 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiat Res. 1998 Jun;149(6):602-13 [9611099] Radiat Res. 2008 Aug;170(2):149-55 [18666821] Radiat Res. 1999 Dec;152(6):655-64 [10581536] Radiat Res. 2001 Oct;156(4):337-46 [11554845] Int J Radiat Biol. 2001 Aug;77(8):901-8 [11571024] Radiat Prot Dosimetry. 2001;97(3):279-82; discussion 285 [11843345] Health Phys. 2002 Apr;82(4):455-66 [11906134] Health Phys. 2002 Dec;83(6):907-17 [12467299] Int J Cancer. 2003 Feb 10;103(4):556-62 [12478675] Health Phys. 2003 Feb;84(2):245-59 [12553655] Radiat Prot Dosimetry. 2003;103(1):35-40 [12596987] Am J Epidemiol. 2003 Apr 1;157(7):652-63 [12672685] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Health Phys. 2003 Jul;85(1):47-59 [12852471] Radiat Prot Dosimetry. 2003;106(2):131-5 [14653333] Lancet. 2004 Jan 31;363(9406):345-51 [15070562] Mutat Res. 1999 Jun 25;442(2):89-95 [10393277] Radiat Res. 2004 Sep;162(3):249-56 [15378837] Radiat Res. 2004 Oct;162(4):377-89 [15447045] Phys Med Biol. 1981 May;26(3):389-400 [7243876] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7474-6 [1881886] Int J Radiat Biol. 1992 Jul;62(1):53-63 [1353776] Radiology. 1993 Nov;189(2):377-80 [8210363] Health Phys. 1995 Feb;68(2):266-9 [7814260] Cytogenet Cell Genet. 1995;68(3-4):211-21 [7842739] Mutat Res. 1995 Oct;338(1-6):95-106 [7565886] Mutagenesis. 1995 Nov;10(6):487-95 [8596467] Environ Health Perspect. 1996 May;104 Suppl 3:489-92 [8781370] Radiat Res. 1997 Sep;148(3):216-26 [9291352] Environ Mol Mutagen. 1997;30(3):264-72 [9366904] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):229-48 [15657915] Radiat Prot Dosimetry. 2005;113(4):396-402 [15928034] Radiat Res. 2005 Nov;164(5):612-7 [16238438] Occup Environ Med. 2005 Dec;62(12):861-7 [16299095] Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] JAMA. 2006 Aug 9;296(6):638-40 [16896096] Mutat Res. 2006 Aug 30;600(1-2):37-45 [16814813] Radiat Res. 2007 Jun;167(6):727-34 [17523852] JAMA. 2007 Jul 18;298(3):317-23 [17635892] N Engl J Med. 2007 Nov 29;357(22):2277-84 [18046031] Mutat Res. 2008 Apr 30;652(2):112-21 [18337160] Radiology. 2008 Jul;248(1):254-63 [18566177] Int J Radiat Biol. 1998 Nov;74(5):565-71 [9848275] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1691 ER - TY - JOUR T1 - Role for nanomaterial-autophagy interaction in neurodegenerative disease. AN - 69726897; 18927490 AB - Nanotechnology is the control and manipulation of materials in the size range of 1-100 nm. Due to increasing research into the potential beneficial applications of nanotechnology, there is an urgent need for the study of possible health risks. Several researchers, including those in our laboratory, have demonstrated elevated levels of autophagic vacuoles upon exposure of cells to certain nanomaterials, including carbon- and metal-based nanoparticles. While this apparent increase in autophagic activity may be an appropriate cellular response toward nanomaterial clearance, often the interaction between nanomaterials and the autophagy pathway is disruptive, resulting in severe morphological changes and coincident cell death. Interestingly, epidemiological studies have identified an association between exposure to combustion-derived ambient particles (which are predominantly nanoscale) and neurological conditions with Alzheimer's and Parkinson's disease-like pathologies. Becuse impaired autophagy may play an important role in the pathogenesis of these and other diseases, it is intriguing to speculate about the plausible involvement of nanoscale particulates in this process. The interaction of nanomaterials with the autophagy pathway, and the potential negative consequences of resulting autophagy dysfunction, should be explored further. JF - Autophagy AU - Stern, Stephan T AU - Johnson, Denise N AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. sternstephan@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1097 EP - 1100 VL - 4 IS - 8 KW - Index Medicus KW - Rats KW - Risk KW - Central Nervous System -- metabolism KW - Animals KW - Particle Size KW - Humans KW - Central Nervous System -- drug effects KW - Central Nervous System -- pathology KW - Mice KW - Cell Line KW - Autophagy -- drug effects KW - Parkinson Disease, Secondary -- pathology KW - Alzheimer Disease -- chemically induced KW - Environmental Pollution KW - Parkinson Disease, Secondary -- etiology KW - Nanoparticles -- toxicity KW - Alzheimer Disease -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69726897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autophagy&rft.atitle=Role+for+nanomaterial-autophagy+interaction+in+neurodegenerative+disease.&rft.au=Stern%2C+Stephan+T%3BJohnson%2C+Denise+N&rft.aulast=Stern&rft.aufirst=Stephan&rft.date=2008-11-01&rft.volume=4&rft.issue=8&rft.spage=1097&rft.isbn=&rft.btitle=&rft.title=Autophagy&rft.issn=1554-8635&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The P2X7 receptor channel pore dilates under physiological ion conditions. AN - 69720257; 18852304 AB - Activation of the purinergic P2X(7) receptor leads to the rapid opening of an integral ion channel that is permeable to small cations. This is followed by a gradual increase in permeability to fluorescent dyes by integrating the actions of the pannexin-1 channel. Here, we show that during the prolonged agonist application a rapid current that peaked within 200 ms was accompanied with a slower current that required tens of seconds to reach its peak. The secondary rise in current was observed under different ionic conditions and temporally coincided with the development of conductivity to larger organic cations. The biphasic response was also observed in cells with blocked pannexin channels and in cells not expressing these channels endogenously. The biphasic current was preserved in N-terminal T15A, T15S, and T15V mutants that have low or no permeability to organic cations, reflecting enhanced permeability to inorganic cations. In contrast, the T15E, T15K, and T15W mutants, and the Delta18 mutant with deleted P2X(7) receptor-specific 18-amino acid C-terminal segment, were instantaneously permeable to organic cations and generated high amplitude monophasic currents. These results indicate that the P2X(7) receptor channel dilates under physiological ion conditions, leading to generation of biphasic current, and that this process is controlled by residues near the intracellular side of the channel pore. JF - The Journal of general physiology AU - Yan, Zonghe AU - Li, Shuo AU - Liang, Zhaodong AU - Tomić, Melanija AU - Stojilkovic, Stanko S AD - Section on Cellular Signaling, Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 563 EP - 573 VL - 132 IS - 5 KW - Cations KW - 0 KW - Connexins KW - Nerve Tissue Proteins KW - P2RX7 protein, human KW - P2rx7 protein, mouse KW - PANX1 protein, human KW - Panx1 protein, mouse KW - Purinergic P2 Receptor Agonists KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2X7 KW - Index Medicus KW - Nerve Tissue Proteins -- drug effects KW - Animals KW - Ion Transport -- drug effects KW - Thermodynamics KW - Electric Conductivity KW - Particle Size KW - Humans KW - Connexins -- drug effects KW - Mice KW - Cell Line, Tumor KW - Ion Transport -- physiology KW - Structure-Activity Relationship KW - Rats KW - Mutagenesis, Site-Directed KW - Kinetics KW - Nerve Tissue Proteins -- metabolism KW - Connexins -- metabolism KW - Cell Membrane Permeability KW - Cell Line, Transformed KW - Cations -- pharmacology KW - Amino Acid Substitution KW - Ion Channel Gating -- physiology KW - Protein Interaction Domains and Motifs -- physiology KW - Protein Interaction Domains and Motifs -- drug effects KW - Receptors, Purinergic P2 -- physiology KW - Ion Channel Gating -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69720257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+physiology&rft.atitle=The+P2X7+receptor+channel+pore+dilates+under+physiological+ion+conditions.&rft.au=Yan%2C+Zonghe%3BLi%2C+Shuo%3BLiang%2C+Zhaodong%3BTomi%C4%87%2C+Melanija%3BStojilkovic%2C+Stanko+S&rft.aulast=Yan&rft.aufirst=Zonghe&rft.date=2008-11-01&rft.volume=132&rft.issue=5&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+physiology&rft.issn=1540-7748&rft_id=info:doi/10.1085%2Fjgp.200810059 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2006 Oct 27;281(43):32649-59 [16954225] Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12063-8 [18689682] Cancer Res. 2007 Feb 15;67(4):1545-54 [17308093] Br J Pharmacol. 2000 May;130(1):167-73 [10781013] Biochim Biophys Acta. 2000 Aug 25;1467(2):444-56 [11030601] Mol Pharmacol. 2000 Nov;58(5):936-45 [11040040] Am J Physiol Cell Physiol. 2001 Apr;280(4):C943-53 [11245611] J Physiol. 2001 Jul 1;534(Pt 1):25-35 [11432989] Physiol Rev. 2002 Oct;82(4):1013-67 [12270951] J Biol Chem. 2003 Mar 7;278(10):8853-60 [12496266] Am J Physiol Cell Physiol. 2003 Aug;285(2):C467-79 [12711592] J Biol Chem. 2003 Nov 28;278(48):47554-61 [12968021] Curr Top Med Chem. 2004;4(8):821-9 [15078213] Science. 1996 May 3;272(5262):735-8 [8614837] Br J Pharmacol. 1997 Aug;121(7):1429-37 [9257924] FEBS Lett. 1997 Jul 14;411(2-3):339-45 [9271232] Neuropharmacology. 1997 Sep;36(9):1285-94 [9364483] EMBO J. 1998 Jun 1;17(11):3016-28 [9606184] Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):102-9 [10048594] Nat Neurosci. 1999 Apr;2(4):315-21 [10204537] Nat Neurosci. 1999 Apr;2(4):322-30 [10204538] J Neurochem. 2005 Feb;92(4):925-33 [15686495] Mol Pharmacol. 2005 Apr;67(4):1078-88 [15632318] J Biol Chem. 2005 Jul 22;280(29):26922-7 [15923180] Am J Physiol Cell Physiol. 2005 Nov;289(5):C1295-302 [16093280] J Physiol. 2006 Mar 15;571(Pt 3):503-17 [16423852] J Immunol. 2006 Apr 1;176(7):3877-83 [16547218] Biophys J. 2007 Apr 1;92(7):2377-91 [17189308] Biophys J. 2007 Aug 1;93(3):846-58 [17483156] Mol Pharmacol. 2007 Dec;72(6):1402-5 [17895406] EMBO J. 2006 Nov 1;25(21):5071-82 [17036048] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1085/jgp.200810059 ER - TY - JOUR T1 - Identification of the invariant chain (CD74) as an angiotensin AGTR1-interacting protein. AN - 69715297; 18719072 AB - Little is known about the protein-protein interactions that regulate the trafficking of the angiotensin II type I receptor (AGTR1) through the biosynthetic pathway. The membrane-proximal region of the cytoplasmic tail of the AGTR1 has been identified by site-directed mutagenesis studies as an essential site for normal AGTR1 folding and surface expression. Based on yeast two-hybrid screening of a human kidney cDNA library with the AGTR1 carboxyl-terminal tail as a bait, we identified the invariant chain (CD74) as a novel interacting protein. This association was confirmed by co-immunoprecipitation and co-localization studies. The binding site for CD74 on the AGTR1 carboxyl-terminal tail was localized to a site previously identified as important for the exit of the AGTR1 from the endoplasmic reticulum (ER), and conserved in many G protein-coupled receptors. Transient co-expression of CD74 with the AGTR1 in CHO-K1 cells consistently reduced the AGTR1 density at the cell surface. Furthermore, the interaction of CD74 with the carboxyl-terminal tail of the AGTR1 caused its retention in the ER and promoted its proteasomal degradation. These observations indicate that CD74 and the AGTR1 become associated in the early biosynthetic pathway, and that CD74 is a negative regulator of AGTR1 expression. JF - The Journal of endocrinology AU - Szaszák, Márta AU - Chen, Hung-Dar AU - Chen, Hao-Chia AU - Baukal, Albert AU - Hunyady, László AU - Catt, Kevin J AD - Endocrinology and Reproduction Research Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-4510, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 165 EP - 176 VL - 199 IS - 2 KW - Antigens, Differentiation, B-Lymphocyte KW - 0 KW - Histocompatibility Antigens Class II KW - Receptor, Angiotensin, Type 1 KW - invariant chain KW - Index Medicus KW - Microscopy, Confocal KW - Protein Binding -- physiology KW - Animals KW - Blotting, Western KW - Cricetulus KW - Transfection KW - Humans KW - Two-Hybrid System Techniques KW - Immunoprecipitation KW - CHO Cells KW - Cell Membrane -- metabolism KW - Cricetinae KW - Antigens, Differentiation, B-Lymphocyte -- metabolism KW - Antigens, Differentiation, B-Lymphocyte -- genetics KW - Receptor, Angiotensin, Type 1 -- genetics KW - Histocompatibility Antigens Class II -- genetics KW - Histocompatibility Antigens Class II -- metabolism KW - Receptor, Angiotensin, Type 1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69715297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+endocrinology&rft.atitle=Identification+of+the+invariant+chain+%28CD74%29+as+an+angiotensin+AGTR1-interacting+protein.&rft.au=Szasz%C3%A1k%2C+M%C3%A1rta%3BChen%2C+Hung-Dar%3BChen%2C+Hao-Chia%3BBaukal%2C+Albert%3BHunyady%2C+L%C3%A1szl%C3%B3%3BCatt%2C+Kevin+J&rft.aulast=Szasz%C3%A1k&rft.aufirst=M%C3%A1rta&rft.date=2008-11-01&rft.volume=199&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+endocrinology&rft.issn=1479-6805&rft_id=info:doi/10.1677%2FJOE-08-0190 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-10 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1677/JOE-08-0190 ER - TY - JOUR T1 - Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury. AN - 69699669; 18703791 AB - The etiology and pathogenesis of angiogenesis in idiopathic pulmonary fibrosis (IPF) is poorly understood. Inter-alpha-trypsin inhibitor (IaI) is a serum protein that can bind to hyaluronan (HA) and may contribute to the angiogenic response to tissue injury. To determine whether IaI promotes HA-mediated angiogenesis in tissue injury. An examination was undertaken of angiogenesis in IaI-sufficient and -deficient mice in the bleomycin model of pulmonary fibrosis and in angiogenesis assays in vivo and in vitro. IaI and HA in patients with IPF were examined. IaI significantly enhances the angiogenic response to short-fragment HA in vivo and in vitro. lal deficiency Ieads to decreased angiogenesis in the matrigel model, and decreases lung angiogenesis after bleomycin exposure in mice. IaI is found in fibroblastic foci in IPF, where it colocalizes with HA. The colocalization is particularly strong in vascular areas around fibroblastic foci. Serum levels of IaI and HA are significantly elevated in patients with IPF compared with control subjects. High serum IaI and HA levels are associated with decreased lung diffusing capacity, but not FVC. Our findings indicate that serum IaI interacts with HA, and promotes angiogenesis in lung injury. IaI appears to contribute to the vascular response to lung injury and may lead to aberrant angiogenesis. Clinical trial registered with www.clinicaltrials.gov (NCT00016627). JF - American journal of respiratory and critical care medicine AU - Garantziotis, Stavros AU - Zudaire, Enrique AU - Trempus, Carol S AU - Hollingsworth, John W AU - Jiang, Dianhua AU - Lancaster, Lisa H AU - Richardson, Elizabeth AU - Zhuo, Lisheng AU - Cuttitta, Frank AU - Brown, Kevin K AU - Noble, Paul W AU - Kimata, Koji AU - Schwartz, David A AD - Clinical Research Unit, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. garantziotis@niehs.nih.gov Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 939 EP - 947 VL - 178 IS - 9 KW - Alpha-Globulins KW - 0 KW - Angiogenesis Inducing Agents KW - Antibiotics, Antineoplastic KW - Bleomycin KW - 11056-06-7 KW - inter-alpha-inhibitor KW - 39346-44-6 KW - Hyaluronic Acid KW - 9004-61-9 KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Lung -- blood supply KW - Animals KW - Antibiotics, Antineoplastic -- administration & dosage KW - Extracellular Matrix -- metabolism KW - Bleomycin -- administration & dosage KW - Vital Capacity KW - Humans KW - Mice, Inbred C57BL KW - Cell Culture Techniques KW - Disease Models, Animal KW - Mice KW - Pulmonary Fibrosis -- blood KW - Lung Injury -- blood KW - Hyaluronic Acid -- blood KW - Neovascularization, Pathologic -- blood KW - Lung Injury -- chemically induced KW - Pulmonary Fibrosis -- physiopathology KW - Angiogenesis Inducing Agents -- blood KW - Lung Injury -- pathology KW - Alpha-Globulins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69699669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Serum+inter-alpha-trypsin+inhibitor+and+matrix+hyaluronan+promote+angiogenesis+in+fibrotic+lung+injury.&rft.au=Garantziotis%2C+Stavros%3BZudaire%2C+Enrique%3BTrempus%2C+Carol+S%3BHollingsworth%2C+John+W%3BJiang%2C+Dianhua%3BLancaster%2C+Lisa+H%3BRichardson%2C+Elizabeth%3BZhuo%2C+Lisheng%3BCuttitta%2C+Frank%3BBrown%2C+Kevin+K%3BNoble%2C+Paul+W%3BKimata%2C+Koji%3BSchwartz%2C+David+A&rft.aulast=Garantziotis&rft.aufirst=Stavros&rft.date=2008-11-01&rft.volume=178&rft.issue=9&rft.spage=939&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1535-4970&rft_id=info:doi/10.1164%2Frccm.200803-386OC LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-01 N1 - Date created - 2008-10-23 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00016627; ClinicalTrials.gov N1 - SuppNotes - Cited By: J Immunol. 2007 Sep 15;179(6):4187-92 [17785858] Eur Respir J. 2007 Apr;29(4):713-9 [17215312] Surgery. 2000 Jun;127(6):696-704 [10840366] J Biol Chem. 2001 Mar 16;276(11):7693-6 [11145954] Am J Respir Crit Care Med. 2001 Dec 15;164(12):2239-42 [11751193] Am J Respir Crit Care Med. 2002 Jan 15;165(2):277-304 [11790668] Methods. 2001 Dec;25(4):402-8 [11846609] Science. 2002 Apr 5;296(5565):155-8 [11935029] Am J Respir Crit Care Med. 2003 Feb 1;167(3):438-43 [12406847] J Invest Dermatol. 2003 Apr;120(4):501-11 [12648211] J Biol Chem. 2003 Nov 21;278(47):47223-31 [12954638] FASEB J. 2004 Apr;18(6):754-6 [14766798] Am J Respir Crit Care Med. 2004 Jun 1;169(11):1203-8 [14754760] Thorax. 2004 Jul;59(7):581-5 [15223865] Am J Respir Crit Care Med. 2004 Jul 15;170(2):133-40 [15044205] Am J Respir Crit Care Med. 2004 Aug 1;170(3):242-51 [15117744] Am J Respir Crit Care Med. 2004 Aug 1;170(3):207-9 [15280169] Crit Care Med. 2004 Aug;32(8):1747-52 [15286553] J Clin Invest. 2004 Aug;114(3):319-21 [15286797] J Biol Chem. 2004 Sep 10;279(37):38079-82 [15151994] J Clin Invest. 1979 Apr;63(4):665-76 [438328] Science. 1985 Jun 14;228(4705):1324-6 [2408340] Thorax. 1989 Feb;44(2):126-31 [2928996] Am Rev Respir Dis. 1991 Feb;143(2):219-25 [1990931] J Invest Dermatol. 1992 Dec;99(6):683-90 [1361507] Am J Respir Crit Care Med. 1994 Feb;149(2 Pt 1):450-4 [8306044] Development. 1993 Dec;119(4):1079-91 [8306876] Am J Respir Crit Care Med. 1995 Apr;151(4):1180-8 [7697250] J Clin Invest. 1996 Nov 15;98(10):2403-13 [8941660] Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1819-28 [8970376] Int J Cancer. 1997 Apr 10;71(2):251-6 [9139851] J Immunol. 1997 Aug 1;159(3):1437-43 [9233641] J Intern Med. 1997 Jul;242(1):27-33 [9260563] J Immunol. 1999 May 1;162(9):5511-8 [10228032] Cell Tissue Res. 1999 Jun;296(3):587-97 [10370146] Thorax. 1963 Sep;18:225-37 [14064617] Am J Respir Crit Care Med. 2005 Nov 1;172(9):1146-52 [16109978] J Biol Chem. 2006 Jan 13;281(2):905-14 [16286479] Chest. 2006 Mar;129(3):746-52 [16537877] Proc Am Thorac Soc. 2006 Jun;3(4):364-72 [16738202] J Biol Chem. 2006 Jul 21;281(29):20303-14 [16702221] Respir Res. 2006;7:82 [16725031] Am J Respir Crit Care Med. 2006 Sep 15;174(6):654-8 [16799077] Am J Respir Crit Care Med. 2006 Oct 1;174(7):803-9 [16825656] Matrix Biol. 2007 Jan;26(1):58-68 [17055233] Chest. 2007 Mar;131(3):650-6 [17317730] Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):646-64 [10673212] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1164/rccm.200803-386OC ER - TY - JOUR T1 - Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. AN - 69693934; 18725543 AB - Emerging evidence suggests that the rewarding, abuse-related effects of nicotine are modulated by the endocannabinoid system of the brain. For example, pharmacological blockade or genetic deletion of cannabinoid CB(1) receptors can reduce or eliminate many abuse-related behavioral and neurochemical effects of nicotine. Furthermore, doses of Delta(9)-tetrahydrocannabinol and nicotine that are ineffective when given alone can induce conditioned place preference when given together. These previous studies have used systemically administered CB(1) receptor agonists and antagonists and gene deletion techniques, which affect cannabinoid CB(1) receptors throughout the brain. A more functionally selective way to alter endocannabinoid activity is to inhibit fatty acid amide hydrolase (FAAH), thereby magnifying and prolonging the effects of the endocannabinoid anandamide only when and where it is synthesized and released on demand. Here, we combined behavioral and neurochemical approaches to evaluate whether the FAAH inhibitor URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) could alter the abuse-related effects of nicotine in rats. We found that URB597, at a dose (0.3 mg/kg) that had no behavioral effects by itself, prevented development of nicotine-induced conditioned place preference (CPP) and acquisition of nicotine self-administration. URB597 also reduced nicotine-induced reinstatement in both CPP and self-administration models of relapse. Furthermore, in vivo microdialysis showed that URB597 reduced nicotine-induced dopamine elevations in the nucleus accumbens shell, the terminal area of the brain's mesolimbic reward system. These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence. JF - The Journal of pharmacology and experimental therapeutics AU - Scherma, Maria AU - Panlilio, Leigh V AU - Fadda, Paola AU - Fattore, Liana AU - Gamaleddin, Islam AU - Le Foll, Bernard AU - Justinová, Zuzana AU - Mikics, Eva AU - Haller, Jozsef AU - Medalie, Julie AU - Stroik, Jessica AU - Barnes, Chanel AU - Yasar, Sevil AU - Tanda, Gianluigi AU - Piomelli, Daniele AU - Fratta, Walter AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 482 EP - 490 VL - 327 IS - 2 KW - Arachidonic Acids KW - 0 KW - Benzamides KW - Carbamates KW - Endocannabinoids KW - Polyunsaturated Alkamides KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Nicotine KW - 6M3C89ZY6R KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - anandamide KW - UR5G69TJKH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Self Administration KW - Rats, Long-Evans KW - Reward KW - Motor Activity -- drug effects KW - Hydrolysis KW - Male KW - Carbamates -- pharmacology KW - Nucleus Accumbens -- chemistry KW - Nucleus Accumbens -- drug effects KW - Arachidonic Acids -- metabolism KW - Polyunsaturated Alkamides -- metabolism KW - Conditioning (Psychology) -- drug effects KW - Benzamides -- pharmacology KW - Tobacco Use Disorder -- drug therapy KW - Amidohydrolases -- physiology KW - Nicotine -- pharmacology KW - Dopamine -- analysis KW - Amidohydrolases -- antagonists & inhibitors KW - Tobacco Use Disorder -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69693934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+anandamide+hydrolysis+by+cyclohexyl+carbamic+acid+3%27-carbamoyl-3-yl+ester+%28URB597%29+reverses+abuse-related+behavioral+and+neurochemical+effects+of+nicotine+in+rats.&rft.au=Scherma%2C+Maria%3BPanlilio%2C+Leigh+V%3BFadda%2C+Paola%3BFattore%2C+Liana%3BGamaleddin%2C+Islam%3BLe+Foll%2C+Bernard%3BJustinov%C3%A1%2C+Zuzana%3BMikics%2C+Eva%3BHaller%2C+Jozsef%3BMedalie%2C+Julie%3BStroik%2C+Jessica%3BBarnes%2C+Chanel%3BYasar%2C+Sevil%3BTanda%2C+Gianluigi%3BPiomelli%2C+Daniele%3BFratta%2C+Walter%3BGoldberg%2C+Steven+R&rft.aulast=Scherma&rft.aufirst=Maria&rft.date=2008-11-01&rft.volume=327&rft.issue=2&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.142224 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nicotine Tob Res. 1999;1 Suppl 2:S121-5; 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AN - 69693802; 18701886 AB - For the first time, relationships among maternal buprenorphine dose, meconium buprenorphine and metabolite concentrations, and neonatal outcomes are reported. Free and total buprenorphine and norbuprenorphine, nicotine, opiates, cocaine, benzodiazepines, and metabolites were quantified in meconium from 10 infants born to women who had received buprenorphine during pregnancy. Neither cumulative nor total third-trimester maternal buprenorphine dose predicted meconium concentrations or neonatal outcomes. Total buprenorphine meconium concentrations and buprenorphine/norbuprenorphine ratios were significantly related to neonatal abstinence syndrome (NAS) scores >4. As free buprenorphine concentration and percentage free buprenorphine increased, head circumference decreased. Thrice-weekly urine tests for opiates, cocaine, and benzodiazepines and self-reported smoking data from the mother were compared with data from analysis of the meconium to estimate in utero exposure. Time of last drug use and frequency of use during the third trimester were important factors associated with drug-positive meconium specimens. The results suggest that buprenorphine and metabolite concentrations in the meconium may predict the onset and frequency of NAS. JF - Clinical pharmacology and therapeutics AU - Kacinko, S L AU - Jones, H E AU - Johnson, R E AU - Choo, R E AU - Huestis, M A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 604 EP - 612 VL - 84 IS - 5 KW - Narcotic Antagonists KW - 0 KW - Opiate Alkaloids KW - Buprenorphine KW - 40D3SCR4GZ KW - Nicotine KW - 6M3C89ZY6R KW - Cocaine KW - I5Y540LHVR KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Maternal Behavior KW - Methadone -- therapeutic use KW - Double-Blind Method KW - Humans KW - Infant, Newborn KW - Neonatal Abstinence Syndrome -- diagnosis KW - Neonatal Abstinence Syndrome -- drug therapy KW - Pregnancy KW - Maternal-Fetal Exchange KW - Adult KW - Smoking -- metabolism KW - Female KW - Male KW - Buprenorphine -- metabolism KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Cocaine -- urine KW - Nicotine -- metabolism KW - Meconium -- chemistry KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- urine KW - Narcotic Antagonists -- metabolism KW - Opioid-Related Disorders -- drug therapy KW - Opiate Alkaloids -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69693802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Correlations+of+maternal+buprenorphine+dose%2C+buprenorphine%2C+and+metabolite+concentrations+in+meconium+with+neonatal+outcomes.&rft.au=Kacinko%2C+S+L%3BJones%2C+H+E%3BJohnson%2C+R+E%3BChoo%2C+R+E%3BHuestis%2C+M+A&rft.aulast=Kacinko&rft.aufirst=S&rft.date=2008-11-01&rft.volume=84&rft.issue=5&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.156 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-05 N1 - Date created - 2008-10-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pediatr. 1994 Mar;124(3):477-9 [8120725] J Forensic Sci. 1994 Jan;39(1):150-8 [8113697] J Perinatol. 1995 May-Jun;15(3):199-202 [7666268] Clin Chem. 1997 Jan;43(1):235-42 [8990259] Forensic Sci Int. 1997 Jan 17;84(1-3):129-35 [9042717] Clin Pharmacol Ther. 1997 Nov;62(5):569-71 [9390114] J Child Adolesc Psychopharmacol. 1998;8(3):161-74 [9853690] Drug Metab Dispos. 2005 May;33(5):689-95 [15743975] Drug Alcohol Depend. 2005 Jul;79(1):1-10 [15943939] J Perinatol. 2006 Jan 1;26(1):15-7 [16355103] Addiction. 2006 Feb;101(2):275-81 [16445556] Drug Metab Dispos. 2006 Apr;34(4):636-46 [16443669] Drug Alcohol Depend. 2006 May 20;82(3):250-7 [16257138] Eur J Neurosci. 2007 Feb;25(3):611-7 [17298594] Expert Opin Drug Metab Toxicol. 2007 Jun;3(3):331-46 [17539742] Obstet Gynecol Surv. 2007 Nov;62(11):749-57 [17925048] Anal Chem. 2008 Jan 1;80(1):246-52 [18044957] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):107-14 [18243821] Pharmacol Ther. 1999 Dec;84(3):429-45 [10665839] Addiction. 2000 Feb;95(2):239-44 [10723852] Pediatrics. 2001 Feb;107(2):309-17 [11158464] Z Geburtshilfe Neonatol. 2001 Nov-Dec;205(6):224-30 [11745008] J Pharmacol Exp Ther. 2002 Jan;300(1):26-33 [11752093] Biochem Pharmacol. 2002 Feb 1;63(3):409-19 [11853692] J Perinat Neonatal Nurs. 2001 Mar;14(4):61-82; quiz 105-6 [11930523] Anal Biochem. 2002 Jul 1;306(1):31-9 [12069411] Hum Reprod. 2002 Oct;17(10):2564-72 [12351530] Int J Neuropsychopharmacol. 2003 Mar;6(1):57-72 [12899737] Drug Alcohol Depend. 2004 Sep 6;75(3):253-60 [15283946] Pediatrics. 2004 Aug;114(2):e226-34 [15286261] Neurobehav Toxicol Teratol. 1986 Jul-Aug;8(4):353-5 [3762845] Pediatrics. 1992 Jan;89(1):107-13 [1727992] J Pediatr. 1994 Sep;125(3):435-40 [8071754] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.156 ER - TY - JOUR T1 - Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. AN - 69691539; 18682571 AB - Cytochrome P450s (P450s) are important enzymes involved in the metabolism of xenobiotics, particularly clinically used drugs, and are also responsible for metabolic activation of chemical carcinogens and toxins. Many xenobiotics can activate nuclear receptors that in turn induce the expression of genes encoding xenobiotic metabolizing enzymes and drug transporters. Marked species differences in the expression and regulation of cytochromes P450 and xenobiotic nuclear receptors exist. Thus, obtaining reliable rodent models to accurately reflect human drug and carcinogen metabolism is severely limited. Humanized transgenic mice were developed in an effort to create more reliable in vivo systems to study and predict human responses to xenobiotics. Human P450s or human xenobiotic-activated nuclear receptors were introduced directly or replaced the corresponding mouse gene, thus creating "humanized" transgenic mice. Mice expressing human CYP1A1/CYP1A2, CYP2E1, CYP2D6, CYP3A4, CY3A7, pregnane X receptor, and peroxisome proliferator-activated receptor alpha were generated and characterized. These humanized mouse models offer a broad utility in the evaluation and prediction of toxicological risk that may aid in the development of safer drugs. JF - The Journal of pharmacology and experimental therapeutics AU - Cheung, Connie AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, 9000 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 288 EP - 299 VL - 327 IS - 2 KW - PPAR alpha KW - 0 KW - Pharmaceutical Preparations KW - Receptors, Steroid KW - pregnane X receptor KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A2 KW - Cytochrome P-450 CYP2D6 KW - Cytochrome P-450 CYP3A KW - Index Medicus KW - Cytochrome P-450 CYP1A2 -- physiology KW - Animals KW - Receptors, Steroid -- physiology KW - Humans KW - Cytochrome P-450 CYP3A -- physiology KW - PPAR alpha -- physiology KW - Mice KW - Cytochrome P-450 CYP2E1 -- physiology KW - Mice, Transgenic KW - Cytochrome P-450 CYP2D6 -- physiology KW - Species Specificity KW - Cytochrome P-450 CYP1A1 -- physiology KW - Pharmaceutical Preparations -- metabolism KW - Cytochrome P-450 Enzyme System -- physiology KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69691539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Humanized+mouse+lines+and+their+application+for+prediction+of+human+drug+metabolism+and+toxicological+risk+assessment.&rft.au=Cheung%2C+Connie%3BGonzalez%2C+Frank+J&rft.aulast=Cheung&rft.aufirst=Connie&rft.date=2008-11-01&rft.volume=327&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.141242 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2008 Feb;36(2):435-41 [18048490] Toxicology. 2008 Apr 3;246(1):9-17 [18248870] Drug Metab Dispos. 2008 May;36(5):955-62 [18276835] Clin Pharmacol Ther. 2008 Jun;83(6):818-28 [18388875] J Exp Med. 2008 Jun 9;205(6):1409-22 [18474629] Toxicology. 1995 Dec 15;104(1-3):1-8 [8560487] J Pharmacol Exp Ther. 1997 Sep;282(3):1435-41 [9316857] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] Mol Pharmacol. 1998 Jan;53(1):14-22 [9443928] Cell. 1998 Jan 9;92(1):73-82 [9489701] J Clin Invest. 1998 Sep 1;102(5):1016-23 [9727070] J Natl Cancer Inst. 1998 Nov 18;90(22):1702-9 [9827524] Annu Rev Pharmacol Toxicol. 1999;39:1-17 [10331074] Cancer Lett. 1999 Sep 1;143(2):149-55 [10503895] Drug Metab Rev. 2004 Oct;36(3-4):497-509 [15554232] Hum Mutat. 2005 Feb;25(2):196-206 [15643613] Drug Metab Dispos. 2005 Mar;33(3):449-57 [15576447] Endocrinology. 2005 Jul;146(7):2911-9 [15817670] Drug Metab Dispos. 2005 Jul;33(7):892-5 [15845749] Chem Res Toxicol. 2005 Sep;18(9):1471-8 [16167840] Annu Rev Pharmacol Toxicol. 2006;46:41-64 [16402898] Mol Endocrinol. 2000 Jan;14(1):27-39 [10628745] Clin Pharmacokinet. 2000 Jan;38(1):41-57 [10668858] Drug Metab Dispos. 2000 Mar;28(3):268-78 [10681370] Nature. 2000 Jul 27;406(6794):435-9 [10935643] Arch Pharm Res. 2000 Oct;23(5):513-7 [11059833] Pharmacogenetics. 2001 Feb;11(1):1-6 [11207026] Xenobiotica. 2000 Dec;30(12):1131-52 [11307970] Bioorg Med Chem Lett. 2001 May 7;11(9):1225-7 [11354382] Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1333-9 [11705737] Mol Pharmacol. 2001 Dec;60(6):1260-7 [11723233] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1259-66 [11751443] Environ Mol Mutagen. 2002;39(2-3):165-70 [11921185] Hepatology. 2002 Jul;36(1):122-34 [12085356] Nat Rev Drug Discov. 2002 Apr;1(4):259-66 [12120277] J Pharmacol Exp Ther. 2002 Oct;303(1):412-23 [12235278] Drug Metab Dispos. 2003 May;31(5):548-58 [12695342] Pharmacogenetics. 2003 Jun;13(6):307-19 [12777961] J Nutr. 2003 Jul;133(7 Suppl):2444S-2447S [12840222] Hepatology. 2003 Oct;38(4):978-88 [14512885] Curr Mol Med. 2003 Sep;3(6):509-18 [14527082] Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):23-37 [14618296] Annu Rev Pharmacol Toxicol. 2004;44:27-42 [14744237] Mol Interv. 2003 Jun;3(4):194-204 [14993447] Pharmacogenetics. 2004 Jan;14(1):1-18 [15128046] J Biol Chem. 2004 Jun 4;279(23):23847-50 [15028720] Cancer Res. 2004 Jun 1;64(11):3849-54 [15172993] J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):139-42 [15225761] Am J Pathol. 2004 Sep;165(3):901-12 [15331414] Science. 1975 Nov 21;190(4216):787-9 [1198095] Lancet. 1977 Sep 17;2(8038):584-6 [71400] Drug Metab Rev. 1981;12(2):221-37 [7040014] Cancer Res. 1982 Nov;42(11):4712-8 [7127306] Chem Res Toxicol. 1992 Sep-Oct;5(5):691-7 [1446011] Biochemistry. 1993 Jun 1;32(21):5598-604 [7684926] Biochem Pharmacol. 1994 Apr 29;47(9):1643-53 [8185679] Chem Res Toxicol. 1994 Nov-Dec;7(6):733-9 [7696526] Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Clin Pharmacol Ther. 1996 Jan;59(1):7-13 [8549036] J Biol Chem. 1996 May 17;271(20):12063-7 [8662637] Physiol Rev. 1997 Apr;77(2):517-44 [9114822] J Pharmacol Exp Ther. 2006 Mar;316(3):1328-34 [16291874] Carcinogenesis. 2006 May;27(5):1074-80 [16377806] Mol Endocrinol. 2006 Nov;20(11):2613-29 [16543404] Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):875-94 [17125407] Arch Biochem Biophys. 2007 Jan 1;457(1):105-10 [17107656] Drug Metab Dispos. 2007 Feb;35(2):194-200 [17093002] Biochem Biophys Res Commun. 2007 Aug 3;359(3):635-42 [17560947] J Clin Invest. 2007 Nov;117(11):3583-92 [17975676] Toxicol Sci. 2008 Jan;101(1):132-9 [17690133] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.141242 ER - TY - JOUR T1 - One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility. AN - 69688136; 18936755 JF - Molecular psychiatry AU - Volkow, N AU - Rutter, J AU - Pollock, J D AU - Shurtleff, D AU - Baler, R AD - Office of the Director, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 990 EP - 992 VL - 13 IS - 11 KW - Protein Subunits KW - 0 KW - Receptors, Nicotinic KW - Index Medicus KW - Protein Subunits -- genetics KW - Humans KW - Tobacco Use Disorder -- genetics KW - Lung Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Receptors, Nicotinic -- genetics KW - Polymorphism, Single Nucleotide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69688136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+psychiatry&rft.atitle=One+SNP+linked+to+two+diseases-addiction+and+cancer%3A+a+double+whammy%3F+Nicotine+addiction+and+lung+cancer+susceptibility.&rft.au=Volkow%2C+N%3BRutter%2C+J%3BPollock%2C+J+D%3BShurtleff%2C+D%3BBaler%2C+R&rft.aulast=Volkow&rft.aufirst=N&rft.date=2008-11-01&rft.volume=13&rft.issue=11&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=Molecular+psychiatry&rft.issn=1476-5578&rft_id=info:doi/10.1038%2Fmp.2008.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-08 N1 - Date created - 2008-10-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/mp.2008.71 ER - TY - JOUR T1 - Catalytic mechanism of human DNA polymerase lambda with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies. AN - 69674916; 18692600 AB - DNA polymerases play a crucial role in the cell cycle due to their involvement in genome replication and repair. Understanding the reaction mechanism by which these polymerases carry out their function can provide insights into these processes. Recently, the crystal structures of human DNA polymerase lambda (Pollambda) have been reported both for pre- and post-catalytic complexes [García-Díaz et al., DNA Repair 3 (2007), 1333]. Here we employ the pre-catalytic complex as a starting structure for the determination of the catalytic mechanism of Pollambda using ab initio quantum mechanical/molecular mechanical methods. The reaction path has been calculated using Mg(2+) and Mn(2+) as the catalytic metals. In both cases the reaction proceeds through a two-step mechanism where the 3'-OH of the primer sugar ring is deprotonated by one of the conserved Asp residues (D490) in the active site before the incorporation of the nucleotide to the nascent DNA chain. A significant charge transfer is observed between both metals and some residues in the active site as the reaction proceeds. The optimized reactant and product structures agree with the reported crystal structures. In addition, the calculated reaction barriers for both metals are close to experimentally estimated barriers. Energy decomposition analysis to explain individual residue contributions suggests that several amino acids surrounding the active site are important for catalysis. Some of these residues, including R420, R488 and E529, have been implicated in catalysis by previous mutagenesis experiments on the homologous residues on Polbeta. Furthermore, Pollambda residues R420 and E529 found to be important from the energy decomposition analysis, are homologous to residues R183 and E295 in Polbeta, both of which are linked to cancer. In addition, residues R386, E391, K422 and K472 appear to have an important role in catalysis and could be a potential target for mutagenesis experiments. There is partial conservation of these residues across the Pol X family of DNA polymerases. JF - DNA repair AU - Cisneros, G Andrés AU - Perera, Lalith AU - García-Díaz, Miguel AU - Bebenek, Katarzyna AU - Kunkel, Thomas A AU - Pedersen, Lee G AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park (RTP), NC 27709, USA. cisnero1@niehs.nih.gov Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 1824 EP - 1834 VL - 7 IS - 11 SN - 1568-7864, 1568-7864 KW - Manganese KW - 42Z2K6ZL8P KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA polymerase beta2 KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Catalytic Domain KW - Crystallography, X-Ray KW - Amino Acid Sequence KW - Molecular Conformation KW - Sequence Homology, Amino Acid KW - Models, Biological KW - Protein Conformation KW - Mutagenesis KW - Catalysis KW - Manganese -- chemistry KW - Magnesium -- chemistry KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69674916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Catalytic+mechanism+of+human+DNA+polymerase+lambda+with+Mg2%2B+and+Mn2%2B+from+ab+initio+quantum+mechanical%2Fmolecular+mechanical+studies.&rft.au=Cisneros%2C+G+Andr%C3%A9s%3BPerera%2C+Lalith%3BGarc%C3%ADa-D%C3%ADaz%2C+Miguel%3BBebenek%2C+Katarzyna%3BKunkel%2C+Thomas+A%3BPedersen%2C+Lee+G&rft.aulast=Cisneros&rft.aufirst=G&rft.date=2008-11-01&rft.volume=7&rft.issue=11&rft.spage=1824&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2008.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chem Phys. 2006 Feb 7;124(5):054109 [16468853] Chem Rev. 2006 Feb;106(2):340-60 [16464009] Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13294-9 [16938895] Biophys J. 2006 Nov 1;91(9):3182-95 [16920835] Biochem Biophys Res Commun. 2006 Nov 24;350(3):521-9 [17022941] Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4267-72 [17360513] J Am Chem Soc. 2007 Apr 18;129(15):4731-7 [17375926] Biochemistry. 2007 May 8;46(18):5463-72 [17419590] DNA Repair (Amst). 2007 Jun 1;6(6):869-75 [17363341] J Mol Graph Model. 2007 Jul;26(1):1-13 [17046299] DNA Repair (Amst). 2007 Sep 1;6(9):1333-40 [17475573] J Am Chem Soc. 2007 Sep 12;129(36):11100-10 [17696533] DNA Repair (Amst). 2007 Dec 1;6(12):1709-25 [17631059] J Phys Chem B. 2008 Jan 24;112(3):1007-15 [18166038] J Am Chem Soc. 2008 Mar 26;130(12):3967-77 [18307346] Annu Rev Phys Chem. 2008;59:573-601 [18393679] Mol Cell. 2008 May 9;30(3):315-24 [18471977] Mutat Res. 1999 Oct 22;435(2):121-8 [10556592] J Mol Biol. 2000 Sep 8;302(1):205-17 [10964570] Acc Chem Res. 2001 Jan;34(1):72-9 [11170358] Biometals. 2002 Sep;15(3):225-35 [12206389] J Phys Chem B. 2007 Sep 27;111(38):11244-52 [17764165] Cancer Cell. 2003 Feb;3(2):105-10 [12620405] Biochemistry. 2003 Jun 24;42(24):7467-76 [12809503] J Am Chem Soc. 2003 Jul 9;125(27):8163-77 [12837086] J Comput Chem. 2003 Sep;24(12):1514-27 [12868114] J Am Chem Soc. 2003 Aug 27;125(34):10384-93 [12926963] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] Nucleic Acids Res. 2003 Dec 1;31(23):6916-25 [14627824] Biochemistry. 2004 Jun 1;43(21):6751-62 [15157109] J Chem Phys. 2004 Jul 8;121(2):697-706 [15260596] J Chem Phys. 2004 May 1;120(17):8039-52 [15267723] Cell Cycle. 2004 Aug;3(8):998-1001 [15280658] J Mol Biol. 1976 May 15;103(2):227-49 [985660] Nature. 1977 Jun 16;267(5612):585-90 [301613] Biochemistry. 1990 May 29;29(21):5027-34 [2198936] Biochemistry. 1995 Dec 12;34(49):15934-42 [8519750] Adv Protein Chem. 2004;69:137-65 [15588842] Nat Struct Mol Biol. 2005 Jan;12(1):97-8 [15608652] J Am Chem Soc. 2005 Mar 23;127(11):4010-20 [15771538] J Chem Phys. 2005 Mar 15;122(11):114502 [15836224] J Biol Chem. 2005 May 6;280(18):18469-75 [15749700] Proc Natl Acad Sci U S A. 2005 May 10;102(19):6819-24 [15863620] J Biol Chem. 2005 Sep 9;280(36):31641-7 [16002405] Nucleic Acids Res. 2005;33(16):5354-61 [16174846] J Comput Chem. 2005 Dec;26(16):1668-88 [16200636] DNA Repair (Amst). 2005 Dec 8;4(12):1358-67 [16213194] Cell. 2006 Jan 27;124(2):331-42 [16439207] Chem Rev. 2006 Aug;106(8):3210-35 [16895325] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2008.07.007 ER - TY - JOUR T1 - Chronic LPS inhalation causes emphysema-like changes in mouse lung that are associated with apoptosis. AN - 69672871; 18539952 AB - Lipopolysaccharide (LPS) is ubiquitous in the environment. Recent epidemiologic data suggest that occupational exposure to inhaled LPS can contribute to the progression of chronic obstructive pulmonary disease. To address the hypothesis that inhaled LPS can cause emphysema-like changes in mouse pulmonary parenchyma, we exposed C57BL/6 mice to aerosolized LPS daily for 4 weeks. By 3 days after the end of the 4-week exposure, LPS-exposed mice developed enlarged airspaces that persisted in the 4-week recovered mice. These architectural alterations in the lung are associated with enhanced type I, III, and IV procollagen mRNA as well as elevated levels of matrix metalloproteinase (MMP)-9 mRNA, all of which have been previously associated with human emphysema. Interestingly, MMP-9-deficient mice were not protected from the development of LPS-induced emphysema. However, we demonstrate that LPS-induced airspace enlargement was associated with apoptosis within the lung parenchyma, as shown by prominent TUNEL staining and elevated cleaved caspase 3 immunoreactivity. Antineutrophil antiserum-treated mice were partially protected from the lung destruction caused by chronic inhalation of LPS. Taken together, these findings demonstrate that inhaled LPS can cause neutrophil-dependent emphysematous changes in lung architecture that are associated with apoptosis and that these changes may be occurring through mechanisms different than those induced by cigarette smoke. JF - American journal of respiratory cell and molecular biology AU - Brass, David M AU - Hollingsworth, John W AU - Cinque, Mark AU - Li, Zhouwei AU - Potts, Erin AU - Toloza, Eric AU - Foster, William M AU - Schwartz, David A AD - Environmental Lung Diseases Research Group, Laboratory of Respiratory Biology, National Heart Lung and Blood Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. david.brass@duke.edu Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 584 EP - 590 VL - 39 IS - 5 KW - Lipopolysaccharides KW - 0 KW - Procollagen KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Index Medicus KW - Neutrophils -- metabolism KW - Animals KW - Matrix Metalloproteinase 9 -- metabolism KW - Matrix Metalloproteinase 9 -- deficiency KW - Procollagen -- metabolism KW - Apoptosis -- drug effects KW - Matrix Metalloproteinase 9 -- genetics KW - Mice KW - Gene Expression Regulation -- drug effects KW - Time Factors KW - Procollagen -- genetics KW - Male KW - Mice, Knockout KW - Inhalation KW - Lipopolysaccharides -- administration & dosage KW - Pulmonary Emphysema -- pathology KW - Pulmonary Emphysema -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69672871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Chronic+LPS+inhalation+causes+emphysema-like+changes+in+mouse+lung+that+are+associated+with+apoptosis.&rft.au=Brass%2C+David+M%3BHollingsworth%2C+John+W%3BCinque%2C+Mark%3BLi%2C+Zhouwei%3BPotts%2C+Erin%3BToloza%2C+Eric%3BFoster%2C+William+M%3BSchwartz%2C+David+A&rft.aulast=Brass&rft.aufirst=David&rft.date=2008-11-01&rft.volume=39&rft.issue=5&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=1535-4989&rft_id=info:doi/10.1165%2Frcmb.2007-0448OC LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-31 N1 - Date created - 2008-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 1987 Oct 1;166(4):1041-54 [3498786] Am Rev Respir Dis. 1990 Sep;142(3):563-70 [2389908] J Immunol. 1988 Dec 15;141(12):4306-12 [2848893] Chest. 1993 Sep;104(3):825-30 [8365296] Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):584-90 [8118622] Am J Respir Crit Care Med. 1994 Sep;150(3):611-7 [8087327] Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1250-5 [7952548] Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):553-8 [10934086] Scand J Work Environ Health. 1990 Dec;16(6):411-22 [2178280] Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):675-83 [1892310] Am J Pathol. 1992 Jul;141(1):153-60 [1632460] J Pathol. 1992 Jul;167(3):349-56 [1517904] Am Rev Respir Dis. 1993 Feb;147(2):442-7 [8094278] Antonie Van Leeuwenhoek. 1993 Jan;63(1):77-83 [8480995] Inflamm Res. 2001 Mar;50(3):129-35 [11339500] Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L952-62 [12376348] Curr Opin Pulm Med. 2003 Mar;9(2):151-5 [12574696] Am J Respir Cell Mol Biol. 2003 May;28(5):555-62 [12707011] Am J Physiol Lung Cell Mol Physiol. 2003 Jun;284(6):L1082-92 [12576296] Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L755-61 [12794002] Am J Pathol. 1996 Oct;149(4):1405-15 [8863687] Exp Lung Res. 1996 Jul-Aug;22(4):449-65 [8872088] Am J Physiol Lung Cell Mol Physiol. 2003 Oct;285(4):L940-8 [12818888] Eur Respir J. 2004 Jun;23(6):932-46 [15219010] J Allergy Clin Immunol. 2004 Sep;114(3):586-92 [15356561] J Immunol. 2004 Sep 15;173(6):3589-93 [15356101] N Engl J Med. 1968 Jun 20;278(25):1355-60 [5650164] Am Rev Respir Dis. 1976 Jul;114(1):137-45 [937830] Thorax. 1982 Mar;37(3):193-7 [6980496] Br J Ind Med. 1984 Aug;41(3):340-5 [6743581] Thorax. 1985 Feb;40(2):132-7 [3975864] Environ Health Perspect. 1986 Apr;66:83-6 [3709487] N Engl J Med. 1987 Sep 3;317(10):605-10 [3614274] Thorax. 1997 Jan;52(1):22-7 [9039235] Lancet. 1997 May 24;349(9064):1498-504 [9167458] Am J Respir Crit Care Med. 1997 Jul;156(1):240-7 [9230755] Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):341-57 [9279209] J Exp Med. 1997 Dec 1;186(11):1831-41 [9382882] Am J Physiol. 1998 Jul;275(1 Pt 1):L14-20 [9688930] Thorax. 1998 May;53(5):398-407 [9708233] Am J Physiol. 1999 May;276(5 Pt 1):L736-43 [10330029] Nat Med. 2005 May;11(5):491-8 [15852018] Eur Respir J. 2005 Nov;26(5):881-6 [16264050] Respir Res. 2005;6:151 [16372907] J Clin Invest. 2006 Mar;116(3):753-9 [16470245] Environ Health. 2006;5:2 [16476167] Histol Histopathol. 2006 Aug;21(8):823-8 [16691534] Proc Am Thorac Soc. 2006 Jul;3(5):424-7 [16799086] J Clin Invest. 2006 Nov;116(11):3050-9 [17053835] Curr Opin Pulm Med. 2007 Mar;13(2):137-41 [17255805] Int J Chron Obstruct Pulmon Dis. 2006;1(3):267-78 [18046864] Am J Respir Cell Mol Biol. 2008 Jun;38(6):639-46 [18192502] J Biol Response Mod. 1990 Feb;9(1):33-43 [2319259] Lancet. 1988 Mar 26;1(8587):663-7 [2895211] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1165/rcmb.2007-0448OC ER - TY - JOUR T1 - Ethanol regulation of D(1) dopamine receptor signaling is mediated by protein kinase C in an isozyme-specific manner. AN - 69672653; 18288091 AB - Ethanol consumption potentiates dopaminergic signaling that is partially mediated by the D(1) dopamine receptor; however, the mechanism(s) underlying ethanol-dependent modulation of D(1) signaling is unclear. We now show that ethanol treatment of D(1) receptor-expressing cells decreases D(1) receptor phosphorylation and concurrently potentiates dopamine-stimulated cAMP accumulation. Protein kinase C (PKC) inhibitors mimic the effects of ethanol on D(1) receptor phosphorylation and dopamine-stimulated cAMP levels in a manner that is non-additive with ethanol treatment. Ethanol was also found to modulate specific PKC activities as demonstrated using in vitro kinase assays where ethanol treatment attenuated the activities of lipid-stimulated PKCgamma and PKCdelta in membrane fractions, but did not affect the activities of PKCalpha, PKCbeta(1), or PKCvarepsilon. Importantly, ethanol treatment potentiated D(1) receptor-mediated DARPP-32 phosphorylation in rat striatal slices, supporting the notion that ethanol enhances D(1) receptor signaling in vivo. These findings suggest that ethanol inhibits the activities of specific PKC isozymes, resulting in decreased D(1) receptor phosphorylation and enhanced dopaminergic signaling. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Rex, Elizabeth B AU - Rankin, Michele L AU - Ariano, Marjorie A AU - Sibley, David R AD - Molecular Neuropharmacology Section, National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 2900 EP - 2911 VL - 33 IS - 12 KW - Central Nervous System Depressants KW - 0 KW - Dopamine and cAMP-Regulated Phosphoprotein 32 KW - Enzyme Inhibitors KW - Isoenzymes KW - Ppp1r1b protein, rat KW - Receptors, Dopamine D1 KW - Ethanol KW - 3K9958V90M KW - Cyclic AMP KW - E0399OZS9N KW - protein kinase C gamma KW - EC 2.7.1.- KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C-delta KW - Index Medicus KW - Animals KW - Protein Kinase C-delta -- metabolism KW - Humans KW - Brain Chemistry -- drug effects KW - Isoenzymes -- drug effects KW - Protein Kinase C-delta -- antagonists & inhibitors KW - Isoenzymes -- metabolism KW - Phosphorylation -- drug effects KW - Alcohol-Induced Disorders, Nervous System -- physiopathology KW - Rats KW - Central Nervous System Depressants -- pharmacology KW - Alcohol-Induced Disorders, Nervous System -- metabolism KW - Down-Regulation -- physiology KW - Dopamine and cAMP-Regulated Phosphoprotein 32 -- metabolism KW - Dopamine and cAMP-Regulated Phosphoprotein 32 -- drug effects KW - Cyclic AMP -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Down-Regulation -- drug effects KW - Cell Line KW - Brain Chemistry -- physiology KW - Protein Kinase C -- metabolism KW - Signal Transduction -- physiology KW - Brain -- enzymology KW - Protein Kinase C -- antagonists & inhibitors KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Signal Transduction -- drug effects KW - Receptors, Dopamine D1 -- drug effects KW - Receptors, Dopamine D1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69672653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Ethanol+regulation+of+D%281%29+dopamine+receptor+signaling+is+mediated+by+protein+kinase+C+in+an+isozyme-specific+manner.&rft.au=Rex%2C+Elizabeth+B%3BRankin%2C+Michele+L%3BAriano%2C+Marjorie+A%3BSibley%2C+David+R&rft.aulast=Rex&rft.aufirst=Elizabeth&rft.date=2008-11-01&rft.volume=33&rft.issue=12&rft.spage=2900&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.16 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.16 ER - TY - JOUR T1 - Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant. AN - 69671876; 18305459 AB - Accumulating evidence suggests the endocannabinoid system modulates environmental cues' ability to induce seeking of drugs, including nicotine and alcohol. However, little attention has been directed toward extending these advances to the growing problem of cannabis use disorders. Therefore, we studied intravenous self-administration of Delta(9)-tetrahydrocannabinol (THC), the main psychoactive constituent of marijuana, using a second-order schedule of drug seeking. Squirrel monkeys' lever responses produced only a brief cue light until the end of the session, when the final response delivered THC along with the cue. When a reinstatement procedure was used to model relapse following a period of abstinence, THC-seeking behavior was robustly reinstated by the cue or by pre-session administration of THC, other cannabinoid agonists, or morphine, but not cocaine. The cannabinoid antagonist rimonabant blocked cue-induced drug seeking, THC-induced drug seeking, and the direct reinforcing effects of THC. Thus, rimonabant and related medications might be effective as treatments for cannabinoid dependence. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Justinova, Zuzana AU - Munzar, Patrik AU - Panlilio, Leigh V AU - Yasar, Sevil AU - Redhi, Godfrey H AU - Tanda, Gianluigi AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Department of Health and Human Services, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 2870 EP - 2877 VL - 33 IS - 12 KW - Analgesics, Opioid KW - 0 KW - Cannabinoid Receptor Modulators KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Morphine KW - 76I7G6D29C KW - Dronabinol KW - 7J8897W37S KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Reinforcement (Psychology) KW - Disease Models, Animal KW - Cannabinoid Receptor Modulators -- antagonists & inhibitors KW - Morphine -- pharmacology KW - Saimiri KW - Cannabinoid Receptor Modulators -- agonists KW - Self Administration KW - Cannabinoid Receptor Modulators -- metabolism KW - Analgesics, Opioid -- pharmacology KW - Cues KW - Secondary Prevention KW - Male KW - Piperidines -- pharmacology KW - Brain -- physiopathology KW - Pyrazoles -- pharmacology KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Marijuana Abuse -- metabolism KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - Marijuana Abuse -- drug therapy KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Brain -- metabolism KW - Marijuana Abuse -- physiopathology KW - Dronabinol -- antagonists & inhibitors KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69671876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Blockade+of+THC-seeking+behavior+and+relapse+in+monkeys+by+the+cannabinoid+CB%281%29-receptor+antagonist+rimonabant.&rft.au=Justinova%2C+Zuzana%3BMunzar%2C+Patrik%3BPanlilio%2C+Leigh+V%3BYasar%2C+Sevil%3BRedhi%2C+Godfrey+H%3BTanda%2C+Gianluigi%3BGoldberg%2C+Steven+R&rft.aulast=Justinova&rft.aufirst=Zuzana&rft.date=2008-11-01&rft.volume=33&rft.issue=12&rft.spage=2870&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.21 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2006 Aug 16;26(33):8531-6 [16914679] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Brain Res Rev. 2007 Jan;53(1):1-16 [16839608] Behav Pharmacol. 2007 Feb;18(1):61-9 [17218798] Eur J Neurosci. 2007 Apr;25(7):2191-200 [17419755] Psychopharmacology (Berl). 2005 May;179(2):452-60 [15821957] J Neurosci. 2005 Jun 8;25(23):5645-50 [15944392] Pharmacol Biochem Behav. 2005 Jun;81(2):285-99 [15932767] Pharmacol Biochem Behav. 2005 Jun;81(2):387-95 [15935455] Trends Pharmacol Sci. 2005 Aug;26(8):420-6 [15992935] Psychopharmacology (Berl). 2006 Jan;183(4):394-403 [16261315] Trends Neurosci. 2006 Apr;29(4):225-32 [16483675] Addiction. 2007 Dec;102(12):1863-70 [18031422] Nat Neurosci. 2000 Nov;3(11):1073-4 [11036260] Behav Pharmacol. 2000 Aug;11(5):377-86 [11103889] Psychopharmacology (Berl). 2000 Dec;153(1):17-30 [11255926] J Neurosci. 2001 Jul 15;21(14):5344-50 [11438610] Nat Med. 2001 Oct;7(10):1151-4 [11590440] Psychopharmacology (Berl). 2002 Oct;163(3-4):327-44 [12373434] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] J Pharmacol Exp Ther. 2003 Jul;306(1):93-102 [12660305] Psychopharmacology (Berl). 2003 Jul;168(1-2):164-9 [12669182] Psychopharmacology (Berl). 2003 Sep;169(2):135-40 [12827345] Psychopharmacology (Berl). 2004 Apr;173(1-2):186-94 [14668977] JAMA. 2004 May 5;291(17):2114-21 [15126440] Br J Pharmacol. 2004 Oct;143(3):343-50 [15339858] J Pharmacol Exp Ther. 1973 Jul;186(1):18-30 [4198773] Fed Proc. 1975 Aug;34(9):1771-6 [1149889] Psychopharmacology (Berl). 1977 Mar 16;51(3):235-42 [403538] Psychopharmacology (Berl). 1998 Dec;140(3):331-44 [9877013] Pharmacol Biochem Behav. 1999 Oct;64(2):327-36 [10515309] Neuropsychopharmacology. 2006 Dec;31(12):2652-9 [16541083] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.21 ER - TY - JOUR T1 - Dynamic interaction between Arf GAP and PH domains of ASAP1 in the regulation of GAP activity. AN - 69665564; 18675341 AB - ASAP family Arf GAPs induce the hydrolysis of GTP bound to the Ras superfamily protein Arf1, regulate cell adhesion and migration and have been implicated in carcinogenesis. The ASAP proteins have a core catalytic domain of PH, Arf GAP and Ank repeat domains. The PH domain is necessary for both biological and catalytic functions of ASAP1 and has been proposed to be integrally folded with the Arf GAP domain. Protection studies and analytical ultracentrifugation studies previously reported indicated that the domains are, at least partly, folded together. Here, using NMR spectroscopy and biochemical analysis, we have further tested this hypothesis and characterized the interdomain interaction. A comparison of NMR spectra of three recombinant proteins comprised of either the isolated PH domain of ASAP1, the Arf GAP and ankyrin repeat domain or all three domains indicated that the PH domain did interact with the Arf GAP and Ank repeat domains; however, we found a significant amount of dynamic independence between the PH and Arf GAP domains, consistent with the interactions being transient. In contrast, the Arf GAP and Ank repeat domains form a relatively rigid structure. The PH-Arf GAP domain interaction partially occluded the phosphoinositide binding site in the soluble protein, but binding studies indicated the PIP2 binding site was accessible in ASAP1 bound to a lipid bilayer surface. Phosphoinositide binding altered the conformation of the PH domain, but had little effect on the structure of the Arf GAP domain. Mutations in a loop of the PH domain that contacts the Arf GAP domain affected PIP2 binding and the K(m) and k(cat) for converting Arf1 GTP to Arf1 GDP. Based on these results, we generated a homology model of a composite PH/Arf GAP/Ank repeat domain structure. We propose that the PH domain contributes to Arf GAP activity by either binding to or positioning Arf1 GTP that is simultaneously bound to the Arf GAP domain. JF - Cellular signalling AU - Luo, Ruibai AU - Miller Jenkins, Lisa M AU - Randazzo, Paul A AU - Gruschus, James AD - Laboratory of Cellular and Molecular Biology, National Institutes of Health, Bethesda, MD 20892, United Sates. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1968 EP - 1977 VL - 20 IS - 11 SN - 0898-6568, 0898-6568 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - GTPase-Activating Proteins KW - Inositol Phosphates KW - Lipid Bilayers KW - Phosphatidylinositol 4,5-Diphosphate KW - Phospholipids KW - ADP-Ribosylation Factors KW - EC 3.6.5.2 KW - Index Medicus KW - Protein Structure, Secondary KW - Models, Molecular KW - Inositol Phosphates -- metabolism KW - Phospholipids -- metabolism KW - Mutation -- genetics KW - Protein Structure, Tertiary KW - Protein Binding KW - Phosphatidylinositol 4,5-Diphosphate -- metabolism KW - Lipid Bilayers -- metabolism KW - Magnetic Resonance Spectroscopy KW - Catalysis KW - Binding Sites KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Adaptor Proteins, Signal Transducing -- chemistry KW - GTPase-Activating Proteins -- metabolism KW - ADP-Ribosylation Factors -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69665564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+signalling&rft.atitle=Dynamic+interaction+between+Arf+GAP+and+PH+domains+of+ASAP1+in+the+regulation+of+GAP+activity.&rft.au=Luo%2C+Ruibai%3BMiller+Jenkins%2C+Lisa+M%3BRandazzo%2C+Paul+A%3BGruschus%2C+James&rft.aulast=Luo&rft.aufirst=Ruibai&rft.date=2008-11-01&rft.volume=20&rft.issue=11&rft.spage=1968&rft.isbn=&rft.btitle=&rft.title=Cellular+signalling&rft.issn=08986568&rft_id=info:doi/10.1016%2Fj.cellsig.2008.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-03 N1 - Date created - 2008-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2003 Jun 6;278(23):21099-104 [12657629] J Biol Chem. 2003 May 16;278(20):18393-400 [12637522] Dev Cell. 2003 Sep;5(3):513-21 [12967569] Cell Signal. 2004 Sep;16(9):1033-44 [15212764] EMBO J. 2004 Oct 13;23(20):3918-28 [15457207] Eur J Biochem. 1991 Dec 5;202(2):569-74 [1761056] J Biomol NMR. 1993 Mar;3(2):185-204 [8477186] Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):816-20 [7846058] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] Science. 1995 Dec 22;270(5244):1999-2002 [8533093] Structure. 1995 Nov 15;3(11):1185-95 [8591029] Cell. 1996 May 31;85(5):621-4 [8646770] Mol Cell Biol. 1998 Dec;18(12):7038-51 [9819391] J Magn Reson. 1999 Oct;140(2):451-9 [10497050] J Biol Chem. 2005 Mar 11;280(10):8884-92 [15632162] EMBO J. 2005 Mar 9;24(5):963-73 [15719014] Clin Cancer Res. 2005 May 15;11(10):3609-13 [15897555] Cell Signal. 2005 Oct;17(10):1276-88 [16038802] J Cell Sci. 2005 Aug 1;118(Pt 15):3555-66 [16079295] Curr Biol. 2005 Dec 6;15(23):2164-9 [16332543] Methods Enzymol. 2005;404:147-63 [16413266] Methods Enzymol. 2005;404:164-74 [16413267] Curr Biol. 2006 Jan 24;16(2):130-9 [16431365] J Cell Sci. 2006 Apr 1;119(Pt 7):1203-11 [16554436] J Biomol NMR. 2006;36 Suppl 1:21 [16642402] Biochemistry. 2006 Dec 26;45(51):15301-9 [17176052] Biochem J. 2007 Mar 15;402(3):439-47 [17112341] J Biol Chem. 2007 Apr 13;282(15):11356-64 [17277311] EMBO J. 2007 Jul 25;26(14):3484-93 [17581628] Biol Cell. 2007 Oct;99(10):583-600 [17868031] Traffic. 2007 Nov;8(11):1465-75 [17666108] Traffic. 2007 Nov;8(11):1644-55 [17760859] Mol Cell Biol. 2007 Dec;27(23):8271-83 [17893324] J Biol Chem. 1994 Apr 8;269(14):10758-63 [8144664] EMBO J. 1999 Dec 15;18(24):6890-8 [10601011] J Biol Chem. 2000 Mar 31;275(13):9653-63 [10734117] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4011-6 [10725410] Methods Enzymol. 2001;329:343-54 [11210554] EMBO J. 2002 Mar 15;21(6):1315-26 [11889037] FEBS Lett. 2002 Feb 20;513(1):71-6 [11911883] Mol Biol Cell. 2002 Jun;13(6):2147-56 [12058076] Genome Res. 2002 Nov;12(11):1625-41 [12421749] J Struct Biol. 2003 Jan;141(1):63-76 [12576021] Traffic. 2003 Apr;4(4):201-13 [12694559] Curr Opin Cell Biol. 2003 Aug;15(4):396-404 [12892779] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cellsig.2008.07.007 ER - TY - JOUR T1 - A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. AN - 69656854; 17524525 AB - Young male Fischer-344 rats were fed a diet containing 2% blueberry (BB) extract or control diet for at least 8 weeks and then received bilateral hippocampal injections of kainic acid (KA 200 ng/0.5 microl) or phosphate buffered saline (PBS). One week later rats were trained in one-way active footshock avoidance in a straight runway followed the next day by training in a footshock motivated 14-unit T-maze with documented sensitivity to hippocampal glutamatergic manipulations. Based on analyses of several performance variables, KA-treated rats exhibited clearly impaired learning performance; however, the BB diet significantly reduced this impairment. Supporting the behavioral findings, stereological assessment of CA1 pyramidal neurons documented greater neuronal loss in KA-treated controls compared to KA-treated rats on the BB diet. In an in vitro experiment, FaO cells grown in medium supplemented with serum from BB-fed rats had enhanced viability after exposure to hydrogen peroxide. These findings suggest that BB supplementation may protect against neurodegeneration and cognitive impairment mediated by excitotoxicity and oxidative stress. JF - Neurobiology of aging AU - Duffy, Kara B AU - Spangler, Edward L AU - Devan, Bryan D AU - Guo, Zhihong AU - Bowker, Jonna L AU - Janas, Anne M AU - Hagepanos, Adrienne AU - Minor, Robin K AU - DeCabo, Rafael AU - Mouton, Peter R AU - Shukitt-Hale, Barbara AU - Joseph, James A AU - Ingram, Donald K AD - Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1680 EP - 1689 VL - 29 IS - 11 KW - Plant Extracts KW - 0 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Phytotherapy -- methods KW - Animals KW - Rats, Inbred F344 KW - Male KW - Fruit -- chemistry KW - Learning Disorders -- physiopathology KW - Oxidative Stress -- drug effects KW - Blueberry Plants -- chemistry KW - Learning -- drug effects KW - Dietary Supplements KW - Plant Extracts -- administration & dosage KW - Learning Disorders -- prevention & control KW - Learning Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69656854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+aging&rft.atitle=A+blueberry-enriched+diet+provides+cellular+protection+against+oxidative+stress+and+reduces+a+kainate-induced+learning+impairment+in+rats.&rft.au=Duffy%2C+Kara+B%3BSpangler%2C+Edward+L%3BDevan%2C+Bryan+D%3BGuo%2C+Zhihong%3BBowker%2C+Jonna+L%3BJanas%2C+Anne+M%3BHagepanos%2C+Adrienne%3BMinor%2C+Robin+K%3BDeCabo%2C+Rafael%3BMouton%2C+Peter+R%3BShukitt-Hale%2C+Barbara%3BJoseph%2C+James+A%3BIngram%2C+Donald+K&rft.aulast=Duffy&rft.aufirst=Kara&rft.date=2008-11-01&rft.volume=29&rft.issue=11&rft.spage=1680&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+aging&rft.issn=1558-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials? AN - 69649769; 18632727 AB - Quantum dots (QDs) are being investigated as novel in vivo imaging agents. The leaching of toxic metals from these QDs in biological systems is of great concern. This study compared the cytotoxic mechanisms of two QD species made of different core materials (cadmium selenide [CdSe] vs. indium gallium phosphide [InGaP]) but similar core sizes (5.1 vs. 3.7 nm) and surface compositions (both ZnS capped, lipid-coated and pegylated). The CdSe QD was found to be 10-fold more toxic to porcine renal proximal tubule cells (LLC-PK1) than the InGaP QD on a molar basis, as determined by MTT assay (48 h IC(50) 10nM for CdSe vs. 100nM for InGaP). Neither of the QD species induced appreciable oxidative stress, as determined by lipid peroxide and reduced glutathione content, suggesting that toxicity was not metal associated. In agreement, treatment of cells with CdSe QDs was not associated with changes in metallothionein-IA (MT-IA) gene expression or Cd-associated caspase 3 enzyme activation. By contrast, incubation of the LLC-PK1 cells with the InGaP QD resulted in a dramatic increase in MT-IA expression by 21- and 43-fold, at 8 and 24 h, respectively. The most remarkable finding was evidence of extensive autophagy in QD-treated cells, as determined by Lysotracker Red dye uptake, TEM, and LC3 immunobloting. Autophagy induction has also been described for other nanomaterials and may represent a common cellular response. These data suggest that QD cytotoxicity is dependent upon properties of the particle as a whole, and not exclusively the metal core materials. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Stern, Stephan T AU - Zolnik, Banu S AU - McLeland, Christopher B AU - Clogston, Jeffery AU - Zheng, Jiwen AU - McNeil, Scott E AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. sternstephan@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 140 EP - 152 VL - 106 IS - 1 KW - Cadmium Compounds KW - 0 KW - Phosphines KW - Selenium Compounds KW - gallium phosphide KW - 12063-98-8 KW - Metallothionein KW - 9038-94-2 KW - cadmium selenide KW - A7F646JC5C KW - Gallium KW - CH46OC8YV4 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Swine KW - Animals KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cell Shape -- drug effects KW - Oxidative Stress -- drug effects KW - LLC-PK1 Cells KW - Inhibitory Concentration 50 KW - Time Factors KW - Metallothionein -- metabolism KW - Caspase 3 -- metabolism KW - Selenium Compounds -- toxicity KW - Epithelial Cells -- ultrastructure KW - Autophagy -- drug effects KW - Quantum Dots KW - Epithelial Cells -- drug effects KW - Kidney -- drug effects KW - Cadmium Compounds -- toxicity KW - Gallium -- toxicity KW - Phosphines -- toxicity KW - Kidney -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69649769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Induction+of+autophagy+in+porcine+kidney+cells+by+quantum+dots%3A+a+common+cellular+response+to+nanomaterials%3F&rft.au=Stern%2C+Stephan+T%3BZolnik%2C+Banu+S%3BMcLeland%2C+Christopher+B%3BClogston%2C+Jeffery%3BZheng%2C+Jiwen%3BMcNeil%2C+Scott+E&rft.aulast=Stern&rft.aufirst=Stephan&rft.date=2008-11-01&rft.volume=106&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfn137 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-23 N1 - Date created - 2008-10-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2003 Mar 14;302(3):496-501 [12615061] Environ Sci Technol. 2005 Mar 1;39(5):1378-83 [15787380] Microbiol Immunol. 2004;48(9):669-75 [15383704] Cancer Res. 1988 Feb 1;48(3):589-601 [3335022] Biochem Pharmacol. 1990 Jun 1;39(11):1751-7 [2344372] Toxicol Appl Pharmacol. 1993 May;120(1):72-9 [8511784] Science. 1998 Sep 25;281(5385):2013-6 [9748157] Nano Lett. 2005 Feb;5(2):331-8 [15794621] J Mol Med (Berl). 2005 May;83(5):377-85 [15688234] Curr Med Chem. 2005;12(10):1161-208 [15892631] Kidney Blood Press Res. 2005;28(3):127-33 [15812196] Biochem Biophys Res Commun. 2005 Nov 11;337(1):52-60 [16185655] J Clin Invest. 2005 Oct;115(10):2679-88 [16200202] Bioconjug Chem. 2005 Nov-Dec;16(6):1488-94 [16287246] Chem Biol. 2005 Nov;12(11):1227-34 [16298302] Circ J. 2006 Jan;70(1):129-40 [16377937] Nano Lett. 2006 Apr;6(4):800-8 [16608287] Anal Bioanal Chem. 2006 May;385(1):105-13 [16547740] Toxicol Appl Pharmacol. 2006 May 1;212(3):212-23 [16169029] Am J Physiol Cell Physiol. 2006 Jun;290(6):C1495-502 [16407415] Autophagy. 2006 Jan-Mar;2(1):39-46 [16874071] Mol Aspects Med. 2006 Oct-Dec;27(5-6):411-25 [16973212] Curr Top Dev Biol. 2006;76:89-101 [17118264] Toxicol Lett. 2006 Dec 15;167(3):191-200 [17049762] Small. 2005 Jul;1(7):706-9 [17193510] J Invest Dermatol. 2007 Jan;127(1):143-53 [16902417] Nano Lett. 2006 Dec;6(12):2826-32 [17163713] Life Sci. 2007 Jan 23;80(7):650-8 [17125799] Langmuir. 2007 Feb 13;23(4):1974-80 [17279683] J Am Chem Soc. 2007 Mar 21;129(11):3333-8 [17319667] Bioconjug Chem. 2007 Mar-Apr;18(2):389-96 [17263568] Autophagy. 2007 May-Jun;3(3):278-81 [17351332] Toxicol In Vitro. 2007 Jun;21(4):677-84 [17383151] J Nanosci Nanotechnol. 2007 Feb;7(2):497-503 [17450785] Autophagy. 2007 Jul-Aug;3(4):371-3 [17438362] Eur J Pharmacol. 2007 Jul 30;568(1-3):89-98 [17560995] Cell Cycle. 2007 Aug 1;6(15):1837-49 [17671424] Nanomedicine (Lond). 2006 Aug;1(2):209-17 [17716110] Environ Health Perspect. 2007 Sep;115(9):1339-43 [17805425] Bioconjug Chem. 2007 Sep-Oct;18(5):1391-6 [17630789] Autophagy. 2007 Nov-Dec;3(6):542-5 [17611390] Sci Total Environ. 2008 Mar 15;392(1):50-8 [18166216] Aquat Toxicol. 2008 Feb 18;86(3):333-40 [18160110] Autophagy. 2007 May-Jun;3(3):181-206 [17224625] EMBO J. 2000 Nov 1;19(21):5720-8 [11060023] Toxicology. 2003 Feb 1;183(1-3):211-20 [12504352] J Pharmacol Exp Ther. 1998 Oct;287(1):344-51 [9765355] J Am Chem Soc. 2005 Mar 2;127(8):2496-504 [15725004] J Am Chem Soc. 2005 Mar 23;127(11):3870-8 [15771523] Biochem Biophys Res Commun. 2004 Jan 9;313(2):453-8 [14684184] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfn137 ER - TY - JOUR T1 - The metabolism of proline, a stress substrate, modulates carcinogenic pathways. AN - 69629737; 18401543 AB - The resurgence of interest in tumor metabolism has led investigators to emphasize the metabolism of proline as a "stress substrate" and to suggest this pathway as a potential anti-tumor target. Proline oxidase, a.k.a. proline dehydrogenase (POX/PRODH), catalyzes the first step in proline degradation and uses proline to generate ATP for survival or reactive oxygen species for programmed cell death. POX/PRODH is induced by p53 under genotoxic stress and initiates apoptosis by both mitochondrial and death receptor pathways. Furthermore, POX/PRODH is induced by PPARgamma and its pharmacologic ligands, the thiazolidinediones. The anti-tumor effects of PPARgamma may be critically dependent on POX/PRODH. In addition, it is upregulated by nutrient stress through the mTOR pathway to maintain ATP levels. We propose that proline is made available as a stress substrate by the degradation of collagen in the microenvironmental extracellular matrix by matrix metalloproteinases. In a manner analogous to autophagy, this proline-dependent process for bioenergetics from collagen in extracellular matrix can be designated "ecophagy". JF - Amino acids AU - Phang, James M AU - Donald, Steven P AU - Pandhare, Jui AU - Liu, Yongmin AD - Laboratory of Comparative Carcinogenesis, Center for Cancer Research, Building 538, Room 115, NCI-Frederick, Frederick, MD 21702, USA. phang@mail.ncifcrf.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 681 EP - 690 VL - 35 IS - 4 KW - Ligands KW - 0 KW - PPAR delta KW - Thiazolidinediones KW - Tumor Suppressor Protein p53 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Proline KW - 9DLQ4CIU6V KW - Proline Oxidase KW - EC 1.5.3.- KW - Protein Kinases KW - EC 2.7.- KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - Index Medicus KW - Protein Kinases -- metabolism KW - Thiazolidinediones -- metabolism KW - Autophagy KW - Adenosine Triphosphate -- metabolism KW - Proline Oxidase -- metabolism KW - PPAR delta -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism KW - Models, Biological KW - Catalysis KW - Proline -- metabolism KW - Gene Expression Regulation, Enzymologic KW - Apoptosis KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69629737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Amino+acids&rft.atitle=The+metabolism+of+proline%2C+a+stress+substrate%2C+modulates+carcinogenic+pathways.&rft.au=Phang%2C+James+M%3BDonald%2C+Steven+P%3BPandhare%2C+Jui%3BLiu%2C+Yongmin&rft.aulast=Phang&rft.aufirst=James&rft.date=2008-11-01&rft.volume=35&rft.issue=4&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Amino+acids&rft.issn=1438-2199&rft_id=info:doi/10.1007%2Fs00726-008-0063-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-03 N1 - Date created - 2008-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00726-008-0063-4 ER - TY - JOUR T1 - Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. AN - 66717577; 19430578 AB - Psychostimulant abuse is a serious social and health problem, for which no effective treatments currently exist. A number of review articles have described predominantly 'clinic'-based pharmacotherapies for the treatment of psychostimulant addiction, but none have yet been shown to be definitively effective for use in humans. In the present article, we review various 'hypothesis'- or 'mechanism'-based pharmacological agents that have been studied at the preclinical level and evaluate their potential use in the treatment of psychostimulant addiction in humans. These compounds target brain neurotransmitter or neuromodulator systems, including dopamine (DA), gamma-aminobutyric acid (GABA), endocannabinoid, glutamate, opioid and serotonin, which have been shown to be critically involved in drug reward and addiction. For drugs in each category, we first briefly review the role of each neurotransmitter system in psychostimulant actions, and then discuss the mechanistic rationale for each drug's potential anti-addiction efficacy, major findings with each drug in animal models of psychostimulant addiction, abuse liability and potential problems, and future research directions. We conclude that hypothesis-based medication development strategies could significantly promote medication discovery for the effective treatment of psychostimulant addiction. JF - Current drug abuse reviews AU - Xi, Zheng-Xiong AU - Gardner, Eliot L AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. zxi@intra.nida.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 303 EP - 327 VL - 1 IS - 3 KW - Cannabinoid Receptor Modulators KW - 0 KW - Central Nervous System Stimulants KW - Dopamine Agonists KW - Dopamine Antagonists KW - Excitatory Amino Acid Agonists KW - GABA Agonists KW - GABA Uptake Inhibitors KW - Narcotic Antagonists KW - Receptors, AMPA KW - Receptors, N-Methyl-D-Aspartate KW - Serotonin Antagonists KW - Serotonin Receptor Agonists KW - Vesicular Monoamine Transport Proteins KW - Glutamic Acid KW - 3KX376GY7L KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - endocannabinoids KW - dopamine KW - Psychostimulant KW - reward KW - reinstatement KW - GABA KW - addiction KW - glutamate KW - Animals KW - Dopamine Antagonists -- therapeutic use KW - Brain -- drug effects KW - GABA Agonists -- therapeutic use KW - Humans KW - Serotonin Antagonists -- adverse effects KW - Cocaine-Related Disorders -- rehabilitation KW - Cannabinoid Receptor Modulators -- metabolism KW - Treatment Outcome KW - gamma-Aminobutyric Acid -- metabolism KW - Excitatory Amino Acid Agonists -- adverse effects KW - Vesicular Monoamine Transport Proteins -- antagonists & inhibitors KW - GABA Agonists -- adverse effects KW - Serotonin Antagonists -- therapeutic use KW - Cocaine-Related Disorders -- diagnosis KW - Glutamic Acid -- metabolism KW - Excitatory Amino Acid Agonists -- therapeutic use KW - Cocaine-Related Disorders -- psychology KW - Dopamine Agonists -- adverse effects KW - Dopamine -- metabolism KW - Receptors, AMPA -- antagonists & inhibitors KW - Dopamine Agonists -- therapeutic use KW - Narcotic Antagonists -- adverse effects KW - Narcotic Antagonists -- therapeutic use KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Dopamine Antagonists -- adverse effects KW - Drug Evaluation, Preclinical KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66717577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+abuse+reviews&rft.atitle=Hypothesis-driven+medication+discovery+for+the+treatment+of+psychostimulant+addiction.&rft.au=Xi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2008-11-01&rft.volume=1&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Current+drug+abuse+reviews&rft.issn=1874-4745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-13 N1 - 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A commentary on Niederdeppe's article AN - 61783792; 200900856 AB - A commentary on Niederdeppe's articles, "Media Campaigns to Promote Smoking Cessation among Socioeconomically Disadvantaged Populations: What Do We Know, What Do We Need to Learn, and What Should We Do Now?". [Copyright 2008 Elsevier Ltd.] JF - Social Science & Medicine AU - Fagan, Pebbles AD - National Cancer Institute, Tobacco Control Research Branch, 6130 Executive Blvd, E 4034, MSC 7337, Bethesda, MD 20892, USA faganp@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1356 EP - 1358 PB - Elsevier Science, Amsterdam The Netherlands VL - 67 IS - 9 SN - 0277-9536, 0277-9536 KW - Smoking cessation Health disparities Media campaigns Community interventions Socioeconomic status (SES) Ethnicity KW - Mass Media Effects KW - Smoking KW - Ethnic Groups KW - Socioeconomic Status KW - Disadvantaged KW - Western Society KW - United States of America KW - Intervention KW - Health Education KW - article KW - 0828: mass phenomena; communication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61783792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Examining+the+evidence+base+of+mass+media+campaigns+for+socially+disadvantaged+populations%3A+What+do+we+know%2C+what+do+we+need+to+learn%2C+and+what+should+we+do+now%3F+A+commentary+on+Niederdeppe%27s+article&rft.au=Fagan%2C+Pebbles&rft.aulast=Fagan&rft.aufirst=Pebbles&rft.date=2008-11-01&rft.volume=67&rft.issue=9&rft.spage=1356&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2008.06.036 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Health Education; Smoking; Intervention; Mass Media Effects; Socioeconomic Status; Disadvantaged; Ethnic Groups; United States of America; Western Society DO - http://dx.doi.org/10.1016/j.socscimed.2008.06.036 ER - TY - JOUR T1 - Rethinking the Ethics of Vital Organ Donations AN - 58795428; 2008-242891 AB - Accepted medical practice already violates the dead donor rule. Explicitly jettisoning the rule- allowing vital organs to be extracted, under certain conditions, from living patients-is a radical change only at the conceptual level. But it would expand the pools of eligible organ donors. Adapted from the source document. JF - Hastings Center Report AU - Miller, Franklin G AU - Truog, Robert D AD - Department of Bioethics, National Institutes of Health Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 38 EP - 46 PB - Hastings Center, Garrison NY VL - 38 IS - 6 SN - 0093-0334, 0093-0334 KW - Health conditions and policy - Medicine and health care KW - Law and ethics - Ethics KW - Donation of organs, tissues, etc. KW - Ethics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58795428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hastings+Center+Report&rft.atitle=Rethinking+the+Ethics+of+Vital+Organ+Donations&rft.au=Miller%2C+Franklin+G%3BTruog%2C+Robert+D&rft.aulast=Miller&rft.aufirst=Franklin&rft.date=2008-11-01&rft.volume=38&rft.issue=6&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Hastings+Center+Report&rft.issn=00930334&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-28 N1 - CODEN - HSCRAS N1 - SubjectsTermNotLitGenreText - Donation of organs, tissues, etc.; Ethics ER - TY - JOUR T1 - Social and physical environments of sports and exercise reported among adults in the American Time Use Survey AN - 57306537; 200918489 AB - Objective Demographic and temporal patterns in the social and physical environments of sports and exercise in the American Time Use Survey (years 2003 -2006) are described. Method The sample consisted of adult respondents (ages 21+) reporting at least one bout of sports or exercise (N = 8844). During the interview, participants reported where (e.g., outdoors, home, work) and with whom (e.g., alone, family, coworkers) each bout occurred. Sample-weighted multinomial logistic regression analyses estimated the adjusted proportion of bouts occurring in each environment by gender, age, education, race/ethnicity, season, weekend/weekday, and time of day. Results Among members of the oldest age group (ages 60+), more exercise bouts occurred alone and outdoors compared to younger age groups. Among college graduates, more exercise bouts occurred at a gym/health club compared to groups with lower levels of education. Exercise bouts occurring alone were most likely to happen in the winter, on weekdays, and in the morning. Exercise bouts occurring outdoors were most likely to happen in the summer, on weekend days, and in the morning. Conclusion Future research and intervention efforts exploring where, when and with whom exercise bouts occur may prove beneficial to addressing public health concerns about physical inactivity. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Dunton, Genevieve Fridlund AU - Berrigan, David AU - Ballard-Barbash, Rachel AU - Graubard, Barry I AU - Atienza, Audie A AD - Health Promotion Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences National Cancer Institute, 6130 Executive Blvd/EPN 4051C, MSC 7365, Bethesda, MD 20892-7365, USA duntong@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 519 EP - 524 PB - Elsevier Ltd, The Netherlands VL - 47 IS - 5 SN - 0091-7435, 0091-7435 KW - Exercise Time Environment Social environment Age groups Education Seasons KW - Time use KW - Built environment KW - Social environment KW - Exercise KW - Sports KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57306537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Social+and+physical+environments+of+sports+and+exercise+reported+among+adults+in+the+American+Time+Use+Survey&rft.au=Dunton%2C+Genevieve+Fridlund%3BBerrigan%2C+David%3BBallard-Barbash%2C+Rachel%3BGraubard%2C+Barry+I%3BAtienza%2C+Audie+A&rft.aulast=Dunton&rft.aufirst=Genevieve&rft.date=2008-11-01&rft.volume=47&rft.issue=5&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2008.07.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Exercise; Sports; Time use; Built environment; Public health; Social environment DO - http://dx.doi.org/10.1016/j.ypmed.2008.07.001 ER - TY - JOUR T1 - Social and Ethical Implications of Genomics, Race, Ethnicity, and Health Inequities AN - 57289380; 200913821 AB - Objectives To review ethical, ethnic/ancestral, and societal issues of genetic and genomic information and technologies in the context of racial and ethnic health disparities. Data Sources Research and journal articles, government reports, web sites. Conclusion As knowledge of human genetic variation and its link to diseases continues to grow, some see race and ethnicity well poised to serve as genetic surrogates in predicting disease etiology and treatment response. However, stereotyping and bias in clinical interactions can be barriers to effective treatment for racial and ethnic minority patients. Implications for Nursing Practice The nursing profession has a key role in assuring that genomic health care does not enhance racial and ethnic health inequities. This will require utilization of new genomic knowledge and caring for each patient as an individual in a culturally and clinically appropriate manner. [Copyright Elsevier B.V.] JF - Seminars in Oncology Nursing AU - Bonham, Vence L AU - Knerr, Sarah Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 254 EP - 261 PB - Elsevier Ltd, The Netherlands VL - 24 IS - 4 SN - 0749-2081, 0749-2081 KW - Human genetics clinical decision-making race health disparities KW - Racial differences KW - Health inequalities KW - Ethnicity KW - Nursing KW - Race KW - Aetiology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57289380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Oncology+Nursing&rft.atitle=Social+and+Ethical+Implications+of+Genomics%2C+Race%2C+Ethnicity%2C+and+Health+Inequities&rft.au=Bonham%2C+Vence+L%3BKnerr%2C+Sarah&rft.aulast=Bonham&rft.aufirst=Vence&rft.date=2008-11-01&rft.volume=24&rft.issue=4&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Oncology+Nursing&rft.issn=07492081&rft_id=info:doi/10.1016%2Fj.soncn.2008.08.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health inequalities; Racial differences; Race; Nursing; Ethnicity; Aetiology DO - http://dx.doi.org/10.1016/j.soncn.2008.08.005 ER - TY - JOUR T1 - Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin AN - 57287108; 200910469 AB - Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Schirmbeck, Frederike AU - Georgi, Alexander AU - Strohmaier, Jana AU - Schmael, Christine AU - Boesshenz, Katja V AU - Muhleisen, Thomas W AU - Herms, Stefan AU - Hoffmann, Per AU - Jamra, Rami Abou AU - Schumacher, Johannes AU - Maier, Wolfgang AU - Propping, Peter AU - Nothen, Markus M AU - Cichon, Sven AU - Rietschel, Marcella AU - Schulze, Thomas G AD - Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1977 EP - 1981 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 10 SN - 0162-3257, 0162-3257 KW - Schizophrenia KW - Genetics KW - Premorbid KW - Vulnerability KW - Phenotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57287108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Brief+Report%3A+No+Association+Between+Premorbid+Adjustment+in+Adult-Onset+Schizophrenia+and+Genetic+Variation+in+Dysbindin&rft.au=Schirmbeck%2C+Frederike%3BGeorgi%2C+Alexander%3BStrohmaier%2C+Jana%3BSchmael%2C+Christine%3BBoesshenz%2C+Katja+V%3BMuhleisen%2C+Thomas+W%3BHerms%2C+Stefan%3BHoffmann%2C+Per%3BJamra%2C+Rami+Abou%3BSchumacher%2C+Johannes%3BMaier%2C+Wolfgang%3BPropping%2C+Peter%3BNothen%2C+Markus+M%3BCichon%2C+Sven%3BRietschel%2C+Marcella%3BSchulze%2C+Thomas+G&rft.aulast=Schirmbeck&rft.aufirst=Frederike&rft.date=2008-11-01&rft.volume=38&rft.issue=10&rft.spage=1977&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0582-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Premorbid; Schizophrenia; Phenotypes; Vulnerability; Genetics DO - http://dx.doi.org/10.1007/s10803-008-0582-6 ER - TY - JOUR T1 - Three-Year Changes in Adult Risk Drinking Behavior in Relation to the Course of Alcohol-Use Disorders AN - 57281598; 200901396 AB - Objective: This study examines the associations between the course of alcohol-use disorder (AUD) and changes in average daily volume of ethanol intake, frequency of risk drinking, and maximum quantity of drinks consumed per day over a 3-year follow-up interval in a sample of U.S. adults. Method: Data were taken from a longitudinal study of a nationally representative sample of U.S. adults, who were 18 years of age and older (mean age = 46.4) when initially interviewed in 2001-2002 and successfully reinterviewed approximately 3 years later (n = 22,245 baseline drinkers). The time reference period for the drinking measures was the 12 months preceding the interview. Changes in consumption reflect differences between Wave 1 and Wave 2 measures for individuals with nonmissing values at both Waves (n = 22,003 for volume of intake, 22,132 for frequency of risk drinking and 21,942 for maximum quantity of drinks). Results: There were positive changes in all consumption measures associated with developing an AUD and negative changes associated with remission of an AUD, even among individuals who continued to drink. Increases and decreases associated with onset and offset of dependence exceeded those associated with onset/offset of abuse only, and the decreases associated with full remission from dependence exceeded those associated with partial remission. There were few changes in consumption among individuals whose AUD status did not change. Interactions of AUD transitions with other factors indicate that development of an AUD is associated with a greater increase in consumption among men, possibly reflecting their greater total body water and lower blood alcohol concentration in response to a given dose of ethanol, and among individuals with high baseline levels of consumption. Conclusions: Changes in consumption associated with onset and offset of AUD are substantial enough to have important implications for the risk of associated physical and psychological harm. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Chou, Patricia AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 3071, MSC 9304, Bethesda, Maryland 20892-9304 ddawson@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 866 EP - 877 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 69 IS - 6 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Remission KW - Problem drinking KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Three-Year+Changes+in+Adult+Risk+Drinking+Behavior+in+Relation+to+the+Course+of+Alcohol-Use+Disorders&rft.au=Dawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BChou%2C+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2008-11-01&rft.volume=69&rft.issue=6&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alcohol related disorders; Alcohol consumption; Remission; Problem drinking ER - TY - JOUR T1 - End-of-life care in Italy: personal experience of family caregivers. A content analysis of open questions from the Italian Survey of the Dying of Cancer (ISDOC) AN - 57274600; 200902165 AB - Objective: This study aims at describing the emotional and practical experience of a representative sample of Italian non-professional caregivers when caring for a terminally ill family member and is part of the Italian Survey of the Dying of Cancer, which involved 2000 adult cancer deaths representative of the whole country. Methods: Information on patients' experience was gathered from non-professional caregivers by an interview. A specific question was asked about the caregivers' emotional and practical experiences while assisting a terminally ill relative. A content analysis of the open question on caregivers' perceptions was performed on transcribed answers. Three researchers independently generated categories. Subsequently, areas where they differed were reconsidered and an interpretation was agreed upon. Results: Valid interviews were obtained from 1231 non-professional caregivers. Answers were classified according to the perception of the experience as positive (33.1%), negative (65.1%) or neutral (1.8%). Conclusion: Assisting a family member with cancer in his/her last three months of life is a very strong physical and mental stress for the caregiver. In some cases, this experience is nevertheless perceived as an evolution chance. Health-care providers should need to develop programs to ensure that family caregivers' needs for information and support are given great importance. [Copyright 2008 John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Morasso, Gabriella AU - Costantini, Massimo AU - Di Leo, Silvia AU - Roma, Serena AU - Miccinesi, Guido AU - Merlo, Domenico Franco AU - Beccaro, Monica AD - Unit of Psycho-Oncology, National Cancer Institute, Genoa, Italy gabriella.morasso@istge.it Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1073 EP - 1080 PB - John Wiley, Chichester UK VL - 17 IS - 11 SN - 1057-9249, 1057-9249 KW - Families KW - Bereavement KW - Italy KW - Cancer KW - Terminally ill people KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57274600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=End-of-life+care+in+Italy%3A+personal+experience+of+family+caregivers.+A+content+analysis+of+open+questions+from+the+Italian+Survey+of+the+Dying+of+Cancer+%28ISDOC%29&rft.au=Morasso%2C+Gabriella%3BCostantini%2C+Massimo%3BDi+Leo%2C+Silvia%3BRoma%2C+Serena%3BMiccinesi%2C+Guido%3BMerlo%2C+Domenico+Franco%3BBeccaro%2C+Monica&rft.aulast=Morasso&rft.aufirst=Gabriella&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1332 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Carers; Families; Cancer; Terminally ill people; Italy; Bereavement DO - http://dx.doi.org/10.1002/pon.1332 ER - TY - JOUR T1 - Anticipated Affective Consequences of Physical Activity Adoption and Maintenance AN - 57273054; 200901465 AB - Objective: The expected emotional consequences of future actions are thought to play an important role in health behavior change. This research examined whether anticipated affective consequences of success and failure vary across stages of physical activity change and differentially predict physical activity adoption as compared to maintenance. Design: Using a prospective design over a 3-smonth period, a community sample of 329 healthy, middle-aged adults were assessed at 2 time points. Main Outcome Measures: Anticipated positive and negative emotions, stage of behavior change (precontemplation [PC], contemplation [C], preparation [P], action [A], maintenance [M]), and level of physical activity. Results: At baseline, anticipated positive emotions were greater in C versus PC, whereas anticipated negative emotions were greater in M versus A and in M versus P. Higher anticipated positive but not negative emotions predicted physical activity adoption and maintenance after 3 months. Conclusion: Although the expected affective consequences of future success and failure differentiated among individuals in the early and later stages of physical activity change, respectively; only the anticipated affective consequences of success predicted future behavior. [Copyright 2008 The American Psychological Association.] JF - Health Psychology AU - Dunton, Genevieve Fridlund AU - Vaughan, Elaine AD - Cancer Prevention Fellow, Health Promotion Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard, EPN Rm 4051C MSC 7355, Bethesda, MD 20892-7365 duntong@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 703 EP - 710 PB - American Psychological Association, Washington DC VL - 27 IS - 6 SN - 0278-6133, 0278-6133 KW - anticipated emotions, stages of change, health behavior, physical activity KW - Negative emotions KW - Physical activity KW - Behavioural changes KW - Stages of change KW - Positive affect KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57273054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Anticipated+Affective+Consequences+of+Physical+Activity+Adoption+and+Maintenance&rft.au=Dunton%2C+Genevieve+Fridlund%3BVaughan%2C+Elaine&rft.aulast=Dunton&rft.aufirst=Genevieve&rft.date=2008-11-01&rft.volume=27&rft.issue=6&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2F0278-6133.27.6.703 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Physical activity; Negative emotions; Health behaviour; Behavioural changes; Stages of change; Positive affect DO - http://dx.doi.org/10.1037/0278-6133.27.6.703 ER - TY - JOUR T1 - Functional Magnetic Resonance Imaging and Pediatric Anxiety AN - 57262890; 200900746 AB - Proceeding in four steps, this review uses research on pediatric anxiety disorders to illustrate how functional magnetic resonance imaging (fMRI) studies may inform therapeutics. First, we describe how; in developmental psychopathology generally, basic and clinical fMRI research guide each other. Second, we discuss how investigators probe specific behaviors associated with anxiety. Here, we focus on one core feature of anxiety, the abnormal modulation of attention. Pictures of angry faces and other threatening stimuli capture attention to a greater degree in anxious than nonanxious patients; in this way, such stimuli interact with and influence a cognitive process called "attention orienting." Using threatening stimuli to manipulate the focus of attention, fMRI studies may eventually test whether interventions such as cognitive behavioral therapy (CBT) reduce anxiety by altering the abnormal orienting of attention. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Pine, Daniel S AU - Guyer, Amanda E AU - Leibenluft, Ellen AD - National Institute of Mental Health, Mood and Anxiety Program, Building 15K, Room 203, 15K North Drive, MSC 2670, Bethesda, MD 20892 pined@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1217 EP - 1221 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 11 SN - 0890-8567, 0890-8567 KW - Paediatrics KW - Anxiety KW - Magnetic resonance imaging KW - Psychopathology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57262890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Functional+Magnetic+Resonance+Imaging+and+Pediatric+Anxiety&rft.au=Pine%2C+Daniel+S%3BGuyer%2C+Amanda+E%3BLeibenluft%2C+Ellen&rft.aulast=Pine&rft.aufirst=Daniel&rft.date=2008-11-01&rft.volume=47&rft.issue=11&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e318185dad0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Paediatrics; Anxiety; Psychopathology DO - http://dx.doi.org/10.1097/CHI.0b013e318185dad0 ER - TY - JOUR T1 - Interpreting GLOBE Societal Practices Scales AN - 57253914; 200823825 AB - Some of the Global Leadership and Organizational Behavior Effectiveness (GLOBE) Societal Practices scales ask for descriptions of typical personality traits that might be interpreted as judgments of national character. Ratings of national character reflect cultural identities and social dynamics, but previous research suggests that they are unrelated to the mean personality traits of the culture's members. Analyses at the culture level comparing GLOBE scales with aggregate assessed personality traits (n = 34) and with measures of perceived national character (n = 33) showed that these GLOBE scales are better construed as unfounded stereotypes than as actual depictions of the society members' personality traits. [Reprinted by permission of Sage Publications Inc., copyright 2008.] JF - Journal of Cross-Cultural Psychology AU - McCrae, Robert R AU - Terracciano, Antonio AU - Realo, Anu AU - Allik, Juri AD - National Institute on Aging, NIH mccraej@grc.nia.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 805 EP - 810 PB - Sage Publications, Thousand Oaks VL - 39 IS - 6 SN - 0022-0221, 0022-0221 KW - personality traits KW - national character KW - cultural identity KW - stereotypes KW - GLOBE scales KW - Scales KW - Personality KW - Cultural identity KW - Organizational behaviour KW - Nationalism KW - Stereotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Psychology&rft.atitle=Interpreting+GLOBE+Societal+Practices+Scales&rft.au=McCrae%2C+Robert+R%3BTerracciano%2C+Antonio%3BRealo%2C+Anu%3BAllik%2C+Juri&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2008-11-01&rft.volume=39&rft.issue=6&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Psychology&rft.issn=00220221&rft_id=info:doi/10.1177%2F0022022108323806 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPGB5 N1 - SubjectsTermNotLitGenreText - Personality; Organizational behaviour; Cultural identity; Stereotypes; Scales; Nationalism DO - http://dx.doi.org/10.1177/0022022108323806 ER - TY - JOUR T1 - A 1,100-year palaeoenvironmental record inferred from stable isotope and trace element compositions of ostracode and plant caryopses in sediments of Cattle Pond, Dongdao Island, South China Sea AN - 50521916; 2009-022589 JF - Journal of Paleolimnology AU - Liu, Xiaodong AU - Sun, Liguang AU - Wei, Gangjian AU - Wang, Yuhong AU - Yan, Hong AU - Liu, Kexin AU - Wu, Xiaohong Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 987 EP - 1002 PB - Springer, Dordrecht VL - 40 IS - 4 SN - 0921-2728, 0921-2728 KW - calcium KW - magnesium KW - Far East KW - oxygen KW - isotopes KW - Xisha Islands KW - Ostracoda KW - Holocene KW - stable isotopes KW - cores KW - West Pacific KW - Cenozoic KW - radioactive isotopes KW - Dongdao Island KW - carbon KW - sediments KW - absolute age KW - Invertebrata KW - Northwest Pacific KW - Asia KW - chemical ratios KW - South China Sea KW - China KW - alkaline earth metals KW - Plantae KW - Quaternary KW - assemblages KW - isotope ratios KW - Crustacea KW - C-13/C-12 KW - O-18/O-16 KW - Mg/Ca KW - paleoenvironment KW - Arthropoda KW - North Pacific KW - metals KW - Mandibulata KW - Pacific Ocean KW - lacustrine environment KW - Cattle Pond KW - C-14 KW - upper Holocene KW - microfossils KW - lake sediments KW - 24:Quaternary geology KW - 03:Geochronology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50521916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Paleolimnology&rft.atitle=A+1%2C100-year+palaeoenvironmental+record+inferred+from+stable+isotope+and+trace+element+compositions+of+ostracode+and+plant+caryopses+in+sediments+of+Cattle+Pond%2C+Dongdao+Island%2C+South+China+Sea&rft.au=Liu%2C+Xiaodong%3BSun%2C+Liguang%3BWei%2C+Gangjian%3BWang%2C+Yuhong%3BYan%2C+Hong%3BLiu%2C+Kexin%3BWu%2C+Xiaohong&rft.aulast=Liu&rft.aufirst=Xiaodong&rft.date=2008-11-01&rft.volume=40&rft.issue=4&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Journal+of+Paleolimnology&rft.issn=09212728&rft_id=info:doi/10.1007%2Fs10933-008-9211-9 L2 - http://www.springerlink.com/(i42ivkufd5oczp45mspwbbyb)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100294,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 66 N1 - Document feature - illus. incl. 1 table, sect., strat. cols., geol. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absolute age; alkaline earth metals; Arthropoda; Asia; assemblages; C-13/C-12; C-14; calcium; carbon; Cattle Pond; Cenozoic; chemical ratios; China; cores; Crustacea; Dongdao Island; Far East; Holocene; Invertebrata; isotope ratios; isotopes; lacustrine environment; lake sediments; magnesium; Mandibulata; metals; Mg/Ca; microfossils; North Pacific; Northwest Pacific; O-18/O-16; Ostracoda; oxygen; Pacific Ocean; paleoenvironment; Plantae; Quaternary; radioactive isotopes; sediments; South China Sea; stable isotopes; upper Holocene; West Pacific; Xisha Islands DO - http://dx.doi.org/10.1007/s10933-008-9211-9 ER - TY - JOUR T1 - The effects of fur rubbing on the social behavior of tufted Capuchin monkeys AN - 37150890; 3874138 AB - Fur rubbing has often been attributed as a social as well as a medicinal function in capuchin monkeys, yet to date there have been no studies investigating the effects of fur rubbing on subsequent group dynamics. Here, we report for the first time how social group cohesion is affected by fur rubbing in tufted capuchin monkeys. Fifteen captive capuchins were each observed six times for 45 min, three times following the provision of materials typically used for fur rubbing (onion) and three times following control food items (apple). When compared with the apple condition, monkeys significantly increased proximity to one another in the first 15 min of the onion condition, which is when most fur rubbing took place. Moreover, monkeys were more likely to spend time in groups when fur rubbing but less likely to spend time in groups when manipulating the onion in other ways. In subsequent periods monkeys were less likely to be in proximity to one another in the onion condition compared with the apple condition. Aggression between group members was elevated whereas affiliation was decreased throughout the onion condition. In short, capuchins spent more time further apart and engaged in more aggressive acts and shorter affiliative acts following fur-rubbing bouts. It is possible that these differences in behavior could be owing to differences in how the monkeys competed for and interacted with the items presented in each condition rather than due to fur rubbing as such. Alternatively, fur rubbing with pungent materials might interfere with olfactory cues used to regulate social interactions within a group and thereby cause increased levels of aggression. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Paukner, Annika AU - Suomi, Stephen J AD - National Institutes of Health Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1007 EP - 1012 VL - 70 IS - 11 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Biological anthropology KW - Primatology KW - Food KW - Primate behaviour KW - Group dynamics KW - Data analysis KW - Aggression KW - Fur UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37150890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=The+effects+of+fur+rubbing+on+the+social+behavior+of+tufted+Capuchin+monkeys&rft.au=Paukner%2C+Annika%3BSuomi%2C+Stephen+J&rft.aulast=Paukner&rft.aufirst=Annika&rft.date=2008-11-01&rft.volume=70&rft.issue=11&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20595 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1608 1077; 10144 10148 10149 1542 11325; 662; Fur; 5648 5636 5676 971; 5114; 3279 971 3286; 10149 DO - http://dx.doi.org/10.1002/ajp.20595 ER - TY - JOUR T1 - Testing different types of genotype-environment correlation: an extended children-of-twins model AN - 37029342; 3805397 AB - This study presents an extended children-of-twins model, which allowed the authors to test the direction of the association between parenting and child adjustment. Three mechanisms were examined: direct phenotypic influence of parenting on child behavior (controlling for both parental and child genotype), passive genotype-environment correlation, and evocative genotype-environment correlation. This model was tested with Monte Carlo simulations. The authors generated data sets consisting of 1,000 twin parent pairs together with their children and 1,000 twin children pairs together with their parents. These simulated data sets were then used to estimate the model, and the procedure was repeated 1,000 times. The simulation results showed that this model recovered the true values of parameters with high precision. The model was also applied to an observed data set to analyze, as a first example, the association between maternal emotional overinvolvement and child internalizing problems. The results showed that this association was best explained by evocative genotype-environment correlation. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Narusyte, Jurgita AU - Neiderhiser, Jenae M AU - D' Onofrio, Brian M AU - Reiss, David AU - Spotts, Erica L AU - Ganiban, Jody AU - Lichtenstein, Paul AD - Karolinska Institute ; Pennsylvania State University ; Indiana University ; Yale University ; National Institute on Aging ; George Washington University Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1591 EP - 1603 VL - 44 IS - 6 SN - 0012-1649, 0012-1649 KW - Economics KW - Sociology KW - Genotype KW - Monte Carlo simulation KW - Social psychology KW - Twins KW - Psychology KW - Parents KW - Children KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37029342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=Testing+different+types+of+genotype-environment+correlation%3A+an+extended+children-of-twins+model&rft.au=Narusyte%2C+Jurgita%3BNeiderhiser%2C+Jenae+M%3BD%27+Onofrio%2C+Brian+M%3BReiss%2C+David%3BSpotts%2C+Erica+L%3BGaniban%2C+Jody%3BLichtenstein%2C+Paul&rft.aulast=Narusyte&rft.aufirst=Jurgita&rft.date=2008-11-01&rft.volume=44&rft.issue=6&rft.spage=1591&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2Fa0013911 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 2212; 9184; 13030 11646 4777 6093; 8268 12265 3865 4025 10214 12224 971 12228 10919; 11901 10404; 10404 DO - http://dx.doi.org/10.1037/a0013911 ER - TY - JOUR T1 - Rationale for Reading Fluconazole MICs at 24 Hours Rather than 48 Hours When Testing Candida spp. by the CLSI M27-A2 Standard Method AN - 21504017; 12494114 AB - We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata. JF - Antimicrobial Agents & Chemotherapy AU - Ostrosky-Zeichner, Luis AU - Rex, John H AU - Pfaller, Michael A AU - Diekema, Daniel J AU - Alexander, Barbara D AU - Andes, David AU - Brown, Steven D AU - Chaturvedi, Vishnu AU - Ghannoum, Mahmoud A AU - Knapp, Cindy C AU - Sheehan, Daniel J AU - Walsh, Thomas J AD - National Cancer Institute, Bethesda, Maryland, Luis.Ostrosky-Zeichner@uth.tmc.edu Luis.Ostrosky-Zeichner@uth.tmc.edu Luis.Ostrosky-Zeichner@uth.tmc.edu Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 4175 EP - 4177 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 52 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Breakpoints KW - fluconazole KW - Data processing KW - Candida glabrata KW - Candida KW - Language KW - Minimum inhibitory concentration KW - Pharmacodynamics KW - A 01340:Antibiotics & Antimicrobials KW - K 03330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21504017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Rationale+for+Reading+Fluconazole+MICs+at+24+Hours+Rather+than+48+Hours+When+Testing+Candida+spp.+by+the+CLSI+M27-A2+Standard+Method&rft.au=Ostrosky-Zeichner%2C+Luis%3BRex%2C+John+H%3BPfaller%2C+Michael+A%3BDiekema%2C+Daniel+J%3BAlexander%2C+Barbara+D%3BAndes%2C+David%3BBrown%2C+Steven+D%3BChaturvedi%2C+Vishnu%3BGhannoum%2C+Mahmoud+A%3BKnapp%2C+Cindy+C%3BSheehan%2C+Daniel+J%3BWalsh%2C+Thomas+J&rft.aulast=Ostrosky-Zeichner&rft.aufirst=Luis&rft.date=2008-11-01&rft.volume=52&rft.issue=11&rft.spage=4175&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00420-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Breakpoints; Data processing; fluconazole; Language; Minimum inhibitory concentration; Pharmacodynamics; Candida glabrata; Candida DO - http://dx.doi.org/10.1128/AAC.00420-08 ER - TY - JOUR T1 - Identification and Characterization of the Plasmodium yoelii PyP140/RON4 Protein, an Orthologue of Toxoplasma gondii RON4, Whose Cysteine-Rich Domain Does Not Protect against Lethal Parasite Challenge Infection AN - 21502641; 12495300 AB - Previously, we identified a Plasmodium yoelii YM 140-kDa merozoite protein, designated PyP140, which formed a complex with apical membrane antigen 1 (AMA1). Furthermore, we produced a nonprotective monoclonal antibody (MAb), 48F8, that immunoprecipitated metabolically labeled PyP140 and localized the protein to the merozoite's apical end and, less frequently, to the merozoite surface, as observed by immunofluorescence assay (IFA). Here, using MAb 48F8, we have identified the pyp140 gene by screening a P. yoelii -Zap cDNA expression library. The pyp140 cDNA covers approximately 90% of the putative open reading frame (ORF) of PY02159 from the P. yoelii NL genome sequencing project. Analysis of the complete gene identified the presence of two introns. The ORF encodes a 102,407-Da protein with an amino-terminal signal sequence, a series of three unique types of repeats, and a cysteine-rich region. The binding site of MAb 48F8 was also identified. A BLAST search with the deduced amino acid sequence shows significant similarity with the Toxoplasma gondii RON4 protein and the Plasmodium falciparum RON4 protein, and the sequence is highly conserved in other Plasmodium species. We produced the cysteine-rich domain of PyP140/RON4 by using the Pichia pastoris expression system and characterized the recombinant protein biochemically and biophysically. BALB/c mice immunized with the protein formulated in oil-in-water adjuvants produced antibodies that recognize parasitized erythrocytes by IFA and native PyP140/RON4 by immunoblotting but failed to protect against a lethal P. yoelii YM infection. Our results show that PyP140/RON4 is located within the rhoptries or micronemes. It may associate in part with AMA1, but the conserved cysteine-rich domain does not appear to elicit inhibitory antibodies, a finding that is supported by the marked sequence conservation in this protein within Plasmodium spp., suggesting that it is not under immune pressure. JF - Infection and Immunity AU - Narum, David L AU - Nguyen, Vu AU - Zhang, Yanling AU - Glen, Jacqueline AU - Shimp, Richard L AU - Lambert, Lynn AU - Ling, Irene T AU - Reiter, Karine AU - Ogun, Solabomi A AU - Long, Carole AU - Holder, Anthony A AU - Herrera, Raul AD - Malaria Vaccine Development Branch, NIH, Rockville, Maryland 20852, dnarum@niaid.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 4876 EP - 4882 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Genomes KW - Apical membrane antigen 1 KW - Parasites KW - Erythrocytes KW - Adjuvants KW - Infection KW - Conserved sequence KW - Plasmodium yoelii KW - Pressure KW - Immunoblotting KW - Monoclonal antibodies KW - Plasmodium falciparum KW - Immunofluorescence KW - Immunity KW - Micronemes KW - Toxoplasma gondii KW - Introns KW - DNA KW - Proteins KW - Merozoites KW - Pichia pastoris KW - Open reading frames KW - Amino acid sequence KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21502641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+and+Characterization+of+the+Plasmodium+yoelii+PyP140%2FRON4+Protein%2C+an+Orthologue+of+Toxoplasma+gondii+RON4%2C+Whose+Cysteine-Rich+Domain+Does+Not+Protect+against+Lethal+Parasite+Challenge+Infection&rft.au=Narum%2C+David+L%3BNguyen%2C+Vu%3BZhang%2C+Yanling%3BGlen%2C+Jacqueline%3BShimp%2C+Richard+L%3BLambert%2C+Lynn%3BLing%2C+Irene+T%3BReiter%2C+Karine%3BOgun%2C+Solabomi+A%3BLong%2C+Carole%3BHolder%2C+Anthony+A%3BHerrera%2C+Raul&rft.aulast=Narum&rft.aufirst=David&rft.date=2008-11-01&rft.volume=76&rft.issue=11&rft.spage=4876&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01717-07 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Parasites; Monoclonal antibodies; Erythrocytes; DNA; Proteins; Immunity; Immunofluorescence; Amino acid sequence; Apical membrane antigen 1; Genomes; Immunoblotting; Adjuvants; Infection; Micronemes; Introns; Conserved sequence; Merozoites; Pressure; Open reading frames; Toxoplasma gondii; Plasmodium yoelii; Plasmodium falciparum; Pichia pastoris DO - http://dx.doi.org/10.1128/IAI.01717-07 ER - TY - JOUR T1 - Outer Surface Protein A Protects Lyme Disease Spirochetes from Acquired Host Immunity in the Tick Vector AN - 21495909; 12495243 AB - The Lyme disease spirochete Borrelia burgdorferi alters the expression of outer surface protein (osp) genes as the bacterium cycles between ticks and mammals. OspA is produced as borreliae enter the tick vector and remains a major surface antigen during midgut colonization. To elucidate the role of OspA in the vector, we created an insertional deletion of ospA in strain B31-A3. The ospA mutant infects mice when it is injected intradermally and is acquired by larval ticks fed on these mice, where it persists through the molt to the nymph stage. Bacterial survival rates in artificially infected tick larvae fed on naive mice were compared with those in the vector fed on immune mice. The ospA mutant proliferates in larvae if it is exposed to blood from naive mice, but it declines in density after larval feeding if the blood is from immune mice. When uninfected larvae are fed on B-cell-deficient mice infected with the ospA mutant, larvae show borrelial densities and persistence that are significantly greater than those fed on infected, immunocompetent mice. We conclude that OspA serves a critical antibody-shielding role during vector blood meal uptake from immune hosts and is not required for persistence in the tick vector. JF - Infection and Immunity AU - Battisti, James M AU - Bono, James L AU - Rosa, Patricia A AU - Schrumpf, Merry E AU - Schwan, Tom G AU - Policastro, Paul F AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, ppolicastro@niaid.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 5228 EP - 5237 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Feeding KW - Borrelia burgdorferi KW - outer surface proteins KW - Ixodidae KW - Larvae KW - Survival KW - Immunity KW - Blood meals KW - Molting KW - OspA protein KW - Colonization KW - Spirochetes KW - Blood KW - outer surface protein A KW - surface antigens KW - Midgut KW - Lyme disease KW - J 02410:Animal Diseases KW - A 01490:Miscellaneous KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21495909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Outer+Surface+Protein+A+Protects+Lyme+Disease+Spirochetes+from+Acquired+Host+Immunity+in+the+Tick+Vector&rft.au=Battisti%2C+James+M%3BBono%2C+James+L%3BRosa%2C+Patricia+A%3BSchrumpf%2C+Merry+E%3BSchwan%2C+Tom+G%3BPolicastro%2C+Paul+F&rft.aulast=Battisti&rft.aufirst=James&rft.date=2008-11-01&rft.volume=76&rft.issue=11&rft.spage=5228&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00410-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Feeding; outer surface proteins; Larvae; Survival; Blood meals; Immunity; Molting; OspA protein; Blood; Spirochetes; Colonization; outer surface protein A; surface antigens; Midgut; Lyme disease; Borrelia burgdorferi; Ixodidae DO - http://dx.doi.org/10.1128/IAI.00410-08 ER - TY - JOUR T1 - Cerebrospinal Fluid and Plasma (13)-?-D-Glucan as Surrogate Markers for Detection and Monitoring of Therapeutic Response in Experimental Hematogenous Candida Meningoencephalitis AN - 21490734; 12494140 AB - The treatment, diagnosis and therapeutic monitoring of hematogenous Candida meningoencephalitis (HCME) are not well understood. We therefore studied the expression of (13)-?-D-glucan (?-glucan) in cerebrospinal fluid (CSF) and plasma in a nonneutropenic rabbit model of experimental HCME treated with micafungin and amphotericin B. Groups studied consisted of micafungin (0.5 to 32 mg/kg) and amphotericin B (1 mg/kg) treatment groups and the untreated controls (UC). Despite well-established infection in the cerebrum, cerebellum, choroid, vitreous humor (102 to 103 CFU/ml), spinal cord, and meninges (10 to 102 CFU/g), only 8.1% of UC CSF cultures were positive. By comparison, all 25 UC CSF samples tested for ?-glucan were positive (755 to 7,750 pg/ml) (P < 0.001). The therapeutic response in CNS tissue was site dependent, with significant decreases of the fungal burden in the cerebrum and cerebellum starting at 8 mg/kg, in the meninges at 2 mg/kg, and in the vitreous humor at 4 mg/kg. A dosage of 24 mg/kg was required to achieve a significant effect in the spinal cord and choroid. Clearance of Candida albicans from blood cultures was not predictive of eradication of organisms from the CNS; conversely, ?-glucan levels in CSF were predictive of the therapeutic response. A significant decrease of ?-glucan concentrations in CSF, in comparison to that for UC, started at 0.5 mg/kg (P < 0.001). Levels of plasma ?-glucan were lower than levels in simultaneously obtained CSF (P < 0.05). CSF ?-glucan levels correlated in a dose-dependent pattern with therapeutic responses and with Candida infection in cerebral tissue (r = 0.842). Micafungin demonstrated dose-dependent and site-dependent activity against HCME. CSF ?-glucan may be a useful biomarker for detection and monitoring of therapeutic response in HCME. JF - Antimicrobial Agents & Chemotherapy AU - Petraitiene, Ruta AU - Petraitis, Vidmantas AU - Hope, William W AU - Mickiene, Diana AU - Kelaher, Amy M AU - Murray, Heidi A AU - Mya-San, Christine AU - Hughes, Johanna E AU - Cotton, Margaret P AU - Bacher, John AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, walsht@mail.nih.gov walsht@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 4121 EP - 4129 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 52 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - Blood culture KW - Amphotericin B KW - Central nervous system KW - Cerebrum KW - Spinal cord KW - Colony-stimulating factor KW - micafungin KW - Meningoencephalitis KW - Cerebellum KW - Animal models KW - Candida albicans KW - Infection KW - vitreous humor KW - biomarkers KW - Models KW - Meninges KW - Cerebrospinal fluid KW - Colony-forming cells KW - K 03410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21490734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Cerebrospinal+Fluid+and+Plasma+%2813%29-%3F-D-Glucan+as+Surrogate+Markers+for+Detection+and+Monitoring+of+Therapeutic+Response+in+Experimental+Hematogenous+Candida+Meningoencephalitis&rft.au=Petraitiene%2C+Ruta%3BPetraitis%2C+Vidmantas%3BHope%2C+William+W%3BMickiene%2C+Diana%3BKelaher%2C+Amy+M%3BMurray%2C+Heidi+A%3BMya-San%2C+Christine%3BHughes%2C+Johanna+E%3BCotton%2C+Margaret+P%3BBacher%2C+John%3BWalsh%2C+Thomas+J&rft.aulast=Petraitiene&rft.aufirst=Ruta&rft.date=2008-11-01&rft.volume=52&rft.issue=11&rft.spage=4121&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00674-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blood culture; Central nervous system; Amphotericin B; Colony-stimulating factor; Spinal cord; Cerebrum; micafungin; Meningoencephalitis; Animal models; Cerebellum; Infection; biomarkers; vitreous humor; Models; Meninges; Cerebrospinal fluid; Colony-forming cells; Candida albicans DO - http://dx.doi.org/10.1128/AAC.00674-08 ER - TY - JOUR T1 - Predictors of Attrition Among High Risk HIV-Infected Participants Enrolled in a Multi-Site Prevention Trial AN - 211253287; 18202908 AB - Retaining high-risk individuals is critical for HIV prevention trials. The current analyses examined predictors of trial dropout among HIV-infected men and women in a multi-site HIV prevention trial. Results indicated that dropouts (n = 74) were more likely to be younger, depressed, and not taking antiretroviral therapy (ART) than those who continued (n = 815). No other background, substance use, or transmission risk differences were found, suggesting no direct evidence of dropout bias on key outcomes. Efforts may be warranted for early detection and treatment of depression and for improving retention of younger participants and those not on ART. [PUBLICATION ABSTRACT] JF - AIDS and Behavior AU - Johnson, Mallory O AU - Dilworth, Samantha E AU - Neilands, Torsten B AU - Chesney, Margaret A AU - Rotheram-borus, Mary Jane AU - Remien, Robert H AU - Weinhardt, Lance AU - Ehrhardt, Anke A AU - Morin, Stephen F Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 974 EP - 7 CY - New York PB - Springer Science & Business Media VL - 12 IS - 6 SN - 10907165 KW - Psychology KW - Anti-HIV Agents KW - Multicenter Studies as Topic KW - Depression KW - HIV Infections -- transmission KW - Humans KW - Predictive Value of Tests KW - HIV-1 KW - Risk KW - Anti-HIV Agents -- therapeutic use KW - Patient Participation -- statistics & numerical data KW - Adult KW - HIV Infections -- drug therapy KW - Female KW - Male KW - Randomized Controlled Trials as Topic KW - HIV Infections -- prevention & control KW - Patient Dropouts -- statistics & numerical data KW - Patient Dropouts -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/211253287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Predictors+of+Attrition+Among+High+Risk+HIV-Infected+Participants+Enrolled+in+a+Multi-Site+Prevention+Trial&rft.au=Johnson%2C+Mallory+O%3BDilworth%2C+Samantha+E%3BNeilands%2C+Torsten+B%3BChesney%2C+Margaret+A%3BRotheram-borus%2C+Mary+Jane%3BRemien%2C+Robert+H%3BWeinhardt%2C+Lance%3BEhrhardt%2C+Anke+A%3BMorin%2C+Stephen+F&rft.aulast=Johnson&rft.aufirst=Mallory&rft.date=2008-11-01&rft.volume=12&rft.issue=6&rft.spage=974&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-007-9356-y LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2008 N1 - Last updated - 2014-09-25 N1 - CODEN - AIBEFC DO - http://dx.doi.org/10.1007/s10461-007-9356-y ER - TY - JOUR T1 - Once is not enough: clinical trials in sepsis AN - 21117462; 8827905 JF - Intensive Care Medicine AU - Sweeney, Daniel A AU - Danner, Robert L AU - Eichacker, Peter Q AU - Natanson, Charles AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 2C145, Bethesda, MD, 20892-1662, USA, sweeneyda@cc.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1955 EP - 1960 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 VL - 34 IS - 11 SN - 0342-4642, 0342-4642 KW - Microbiology Abstracts B: Bacteriology KW - Sepsis KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21117462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Once+is+not+enough%3A+clinical+trials+in+sepsis&rft.au=Sweeney%2C+Daniel+A%3BDanner%2C+Robert+L%3BEichacker%2C+Peter+Q%3BNatanson%2C+Charles&rft.aulast=Sweeney&rft.aufirst=Daniel&rft.date=2008-11-01&rft.volume=34&rft.issue=11&rft.spage=1955&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-008-1274-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Sepsis; Clinical trials DO - http://dx.doi.org/10.1007/s00134-008-1274-6 ER - TY - JOUR T1 - Chronic NMDA Administration Increases Neuroinflammatory Markers in Rat Frontal Cortex: Cross-Talk Between Excitotoxicity and Neuroinflammation AN - 21062857; 8597461 AB - Chronic N-Methyl-d-aspartate (NMDA) administration, a model of excitotoxicity, and chronic intracerebroventricular lipopolysaccharide infusion, a model of neuroinflammation, are reported to upregulate arachidonic acid incorporation and turnover in rat brain phospholipids as well as enzymes involved in arachidonic acid metabolism. This suggests cross-talk between signaling pathways of excitotoxicity and of neuroinflammation, involving arachidonic acid. To test whether chronic NMDA administrations to rats can upregulate brain markers of neuroinflammation, NMDA (25 mg/kg i.p.) or vehicle (1 ml saline/kg i.p.) was administered daily to adult male rats for 21 days. Protein and mRNA levels of cytokines and other inflammatory markers were measured in the frontal cortex using immunoblot and real-time PCR. Compared with chronic vehicle, chronic NMDA significantly increased protein and mRNA levels of interleukin-1beta, tumor necrosis factor alpha, glial fibrillary acidic protein and inducible nitric oxide synthase. Chronic NMDA receptor overactivation results in increased levels of neuroinflammatory markers in the rat frontal cortex, consistent with cross-talk between excitotoxicity and neuroinflammation. As both processes have been reported in a number of human brain diseases, NMDA receptor inhibitors might be of use in treating neuroinflammation in these diseases. JF - Neurochemical Research AU - Chang, Yunyoung C AU - Kim, Hyung-Wook AU - Rapoport, Stanley I AU - Rao, Jagadeesh S AD - National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg. 9, 1S-126, Bethesda, MD, 20892, USA, jrao@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 2318 EP - 2323 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 33 IS - 11 SN - 0364-3190, 0364-3190 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; CSA Neurosciences Abstracts KW - N-Methyl-D-aspartic acid receptors KW - Glial fibrillary acidic protein KW - Animal models KW - Brain KW - Enzymes KW - Cortex (frontal) KW - Arachidonic acid KW - Glutamic acid receptors (ionotropic) KW - mRNA KW - Inflammation KW - Nitric-oxide synthase KW - Polymerase chain reaction KW - Lipopolysaccharides KW - Tumor necrosis factor- alpha KW - Excitotoxicity KW - Metabolism KW - Phospholipids KW - Signal transduction KW - N3 11008:Neurochemistry KW - F 06910:Microorganisms & Parasites KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21062857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+Research&rft.atitle=Chronic+NMDA+Administration+Increases+Neuroinflammatory+Markers+in+Rat+Frontal+Cortex%3A+Cross-Talk+Between+Excitotoxicity+and+Neuroinflammation&rft.au=Chang%2C+Yunyoung+C%3BKim%2C+Hyung-Wook%3BRapoport%2C+Stanley+I%3BRao%2C+Jagadeesh+S&rft.aulast=Chang&rft.aufirst=Yunyoung&rft.date=2008-11-01&rft.volume=33&rft.issue=11&rft.spage=2318&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/10.1007%2Fs11064-008-9731-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - N-Methyl-D-aspartic acid receptors; Brain; Animal models; Glial fibrillary acidic protein; Arachidonic acid; Cortex (frontal); Enzymes; Glutamic acid receptors (ionotropic); Inflammation; mRNA; Nitric-oxide synthase; Lipopolysaccharides; Polymerase chain reaction; Tumor necrosis factor- alpha; Metabolism; Excitotoxicity; Signal transduction; Phospholipids DO - http://dx.doi.org/10.1007/s11064-008-9731-8 ER - TY - JOUR T1 - A novel immunoregulatory axis of NKT cell subsets regulating tumor immunity AN - 20922018; 8490661 AB - There are many mechanisms that regulate and dampen the immune response to cancers, including several types of regulatory T cells. Besides the T reg cell, we have identified another immunoregulatory circuit initiated by NKT cells that produce IL-13 in response to tumor growth and this IL-13 then induces myeloid cells to make TGF- beta that inhibits cytotoxic T cell-mediated tumor immunosurveillance in several mouse tumor models. This finding created a paradox in the role of NKT cells in tumor immunity, in that they can also contribute to protection. We resolve this paradox by the finding that the suppressive NKT cell is a type II NKT cell that lacks the canonical invariant T cell receptor, whereas the protective cell is a type I NKT cell that expresses the invariant receptor. Further, we see that these two subsets of NKT cells counter-regulate each other, defining a new immunoregulatory axis. The balance along this axis may determine the outcome of tumor immunosurveillance as well as influence the efficacy of anti-cancer vaccines and immunotherapy. JF - Cancer Immunology, Immunotherapy AU - Berzofsky, Jay A AU - Terabe, Masaki AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA, berzofsk@helix.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1679 EP - 1683 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 57 IS - 11 SN - 0340-7004, 0340-7004 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Immunoregulation KW - Immunotherapy KW - double prime T-cell receptor KW - Animal models KW - Natural killer cells KW - Circuits KW - Tumors KW - Myeloid cells KW - Cancer KW - Interleukin 13 KW - Cytotoxicity KW - Immunosurveillance KW - Transforming growth factor- beta KW - Lymphocytes T KW - Vaccines KW - F 06915:Cancer Immunology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20922018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Immunology%2C+Immunotherapy&rft.atitle=A+novel+immunoregulatory+axis+of+NKT+cell+subsets+regulating+tumor+immunity&rft.au=Berzofsky%2C+Jay+A%3BTerabe%2C+Masaki&rft.aulast=Berzofsky&rft.aufirst=Jay&rft.date=2008-11-01&rft.volume=57&rft.issue=11&rft.spage=1679&rft.isbn=&rft.btitle=&rft.title=Cancer+Immunology%2C+Immunotherapy&rft.issn=03407004&rft_id=info:doi/10.1007%2Fs00262-008-0495-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Immunoregulation; double prime T-cell receptor; Immunotherapy; Natural killer cells; Animal models; Circuits; Tumors; Myeloid cells; Cancer; Cytotoxicity; Interleukin 13; Immunosurveillance; Transforming growth factor- beta; Lymphocytes T; Vaccines DO - http://dx.doi.org/10.1007/s00262-008-0495-4 ER - TY - JOUR T1 - Prediagnostic Adiponectin Concentrations and Pancreatic Cancer Risk in Male Smokers AN - 20740753; 9145063 AB - Adiponectin, a hormone secreted by adipocytes, has insulin-sensitizing, antidiabetic, antiinflammatory, and antiangiogenic properties. The authors conducted a nested case-control study in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort, a cohort of male Finnish smokers aged 50-69 years at baseline, to test whether prediagnostic adiponectin concentrations are associated with pancreatic cancer. Between January 1985 and October 2004, 311 incident exocrine pancreatic cancer cases were diagnosed among cohort participants with serum samples. Controls (n = 510) were alive and free of cancer at the time the case was diagnosed and were matched to the cases by age and date of blood drawing. The authors used conditional logistic regression adjusted for smoking, blood pressure, and C-peptide level to calculate odds ratios and 95% confidence intervals for pancreatic cancer. Higher adiponectin concentrations were inversely associated with pancreatic cancer (for highest quintile (>9.8 mu g/mL) vs. lowest ( less than or equal to 4.6 mu g/mL), odds ratio=0.65, 95% confidence interval: 0.39, 1.07; P-trend=0.04). The inverse association was significant among cases diagnosed 5 or more years after blood collection (n=238) (for highest quintile vs. lowest, odds ratio=0.55, 95% confidence interval: 0.31, 0.98; P-trend=0.03). These results support the hypothesis that higher adiponectin concentrations may be inversely associated with the development of pancreatic cancer. JF - American Journal of Epidemiology AU - Stolzenberg-Solomon, Rachael Z AU - Weinstein, Stephanie AU - Pollak, Michael AU - Tao, Yuzhen AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 1047 EP - 1055 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 168 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - adenocarcinoma KW - adiponectin KW - biological markers KW - case-control studies KW - diabetes mellitus KW - pancreatic neoplasms KW - Smoking KW - pancreatic cancer KW - Age KW - prevention KW - males KW - Hormones KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20740753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Prediagnostic+Adiponectin+Concentrations+and+Pancreatic+Cancer+Risk+in+Male+Smokers&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BWeinstein%2C+Stephanie%3BPollak%2C+Michael%3BTao%2C+Yuzhen%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2008-11-01&rft.volume=168&rft.issue=9&rft.spage=1047&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwn221 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Age; pancreatic cancer; prevention; males; Hormones; Cancer DO - http://dx.doi.org/10.1093/aje/kwn221 ER - TY - JOUR T1 - Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study AN - 20731347; 8596771 AB - Objective: In order to prospectively investigate physical activity at varying intensities and sedentary behavior in relation to colorectal cancer. Methods: We considered 488,720 participants of the NIH-AARP Diet and Health Study who were aged 50-71 years at baseline in 1995-1996. Through 31 December, 2003, we identified 3,240 and 1,482 colorectal cancers among men and women, respectively. We estimated multivariable relative risks (RR) and 95% confidence intervals (CI) of colorectal cancer using Cox regression. Results: Engaging in exercise/sports five or more times per week compared to never or rarely exercising was associated with a reduced risk of colon cancer among men (p = 0.001; RR = 0.79, 95% CI = 0.68-0.91) and a suggestive decrease in risk among women (p = 0.376; RR = 0.85, 95% CI = 0.70-1.04). Engaging in exercise/sports was also associated with a decreased risk of rectal cancer in men (P = 0.074; RR comparing extreme categories = 0.76, 95% CI = 0.61-0.94). In men, we observed inverse relations of both low intensity (p = 0.017; RR = 0.81, 95% CI = 0.65-1.00 for greater than or equal to 7 h/week) and moderate to vigorous intensity activity (p = 0.037; RR = 0.82, 95% CI = 0.67-0.99 for greater than or equal to 7 h/week) to colon cancer risk. In contrast, sedentary behavior (time spent watching television/videos) was positively associated with colon cancer (p < 0.001; RR = 1.61, 95% CI = 1.14-2.27 for greater than or equal to 9 h/day) among men. Similar, but less pronounced relations were observed in women. Conclusion: Engaging in physical activity of any intensity is associated with reductions in colon and rectal cancer risk. Conversely, time spent sedentary is associated with increased colon cancer risk. JF - Cancer Causes & Control AU - Howard, Regan A AU - Freedman, DMichal AU - Park, Yikyung AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - National Cancer Institute, NIH, DHHS, Executive Plaza South, Suite 7091, Bethesda, MD, 20892, USA, reganho@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 939 EP - 953 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 19 IS - 9 SN - 0957-5243, 0957-5243 KW - Physical Education Index; Risk Abstracts KW - Diets KW - Men KW - Women KW - Health (behavior) KW - Exercise KW - Cancer KW - risk reduction KW - Behavior KW - colorectal carcinoma KW - Exercise (intensity) KW - Objectives KW - Television KW - Diet KW - physical activity KW - R2 23060:Medical and environmental health KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20731347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+in+Human+Behavior&rft.atitle=Cognitive-bias+toward+gaming-related+words+and+disinhibition+in+World+of+Warcraft+gamers&rft.au=Decker%2C+Seamus+A.%3BGay%2C+Jessica+N.&rft.aulast=Decker&rft.aufirst=Seamus&rft.date=2011-03-01&rft.volume=27&rft.issue=2&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Computers+in+Human+Behavior&rft.issn=07475632&rft_id=info:doi/10.1016%2Fj.chb.2010.11.005 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Behavior; Exercise (intensity); Men; Objectives; Women; Health (behavior); Diet; Exercise; Cancer; Diets; risk reduction; colorectal carcinoma; Television; physical activity DO - http://dx.doi.org/10.1007/s10552-008-9159-0 ER - TY - JOUR T1 - Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors AN - 20730759; 8596767 AB - Testicular germ cell tumors (TGCT) that arise in young men are composed of two histologic types, seminomas and nonseminomas. Risk patterns for the two types appear to be similar and may be related to either endogenous or exogenous hormonal exposures in utero. Why similar risk patterns would result in different histologic types is unclear, but could be related to varying genetic susceptibility profiles. Genetic variation in hormone metabolizing genes could potentially modify hormonal exposures, and thereby affect which histologic type a man develops. To examine this hypothesis, 33 single nucleotide polymorphisms (SNPs) in four hormone metabolism candidate genes (CYP1A1,CYP17A1,HSD17B1,HSD17B4) and the androgen receptor gene (AR) were genotyped. Associations with TGCT were evaluated among 577 TGCT cases (254 seminoma, 323 nonseminoma) and 707 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) study. There were no significant associations with TGCT overall based on a test using an additive model. However, compared to homozygotes of the most common allele, two nonredundant SNPs in CYP1A1 were inversely associated with nonseminoma: CYP1A1 promoter SNP rs4886605 OR = 0.75 (95% CI = 0.54-1.04) among the heterozygotes and OR = 0.37, 95% CI = 0.12-1.11 among the homozygotes with a p-value for trend = 0.02; rs2606345 intron 1 SNP, OR = 0.69 (95% CI = 0.51-0.93) among heterozygotes and OR = 0.70 (95% CI = 0.42-1.17) among homozygotes, with a p-value for trend = 0.02. Caution in interpretation is warranted until findings are replicated in other studies; however, the results suggest that genetic variation in CYP1A1 may be associated with nonseminoma. JF - Cancer Causes & Control AU - Figueroa, Jonine D AU - Sakoda, Lori C AU - Graubard, Barry I AU - Chanock, Stephen AU - Rubertone, Mark V AU - Erickson, RLoren AU - McGlynn, Katherine A AD - National Cancer Institute, Bethesda, MD, USA, figueroaj@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 917 EP - 929 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 19 IS - 9 SN - 0957-5243, 0957-5243 KW - Genetics Abstracts; Risk Abstracts; Toxicology Abstracts KW - Testes KW - Germ cells KW - Genetic diversity KW - tumors KW - genetic diversity KW - Tumors KW - Hormones KW - Cancer KW - Homozygotes KW - Androgen receptors KW - Promoters KW - introns KW - Single-nucleotide polymorphism KW - Heterozygotes KW - Introns KW - Cytochrome P450 KW - seminoma KW - Metabolism KW - X 24490:Other KW - R2 23060:Medical and environmental health KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20730759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Genetic+variation+in+hormone+metabolizing+genes+and+risk+of+testicular+germ+cell+tumors&rft.au=Figueroa%2C+Jonine+D%3BSakoda%2C+Lori+C%3BGraubard%2C+Barry+I%3BChanock%2C+Stephen%3BRubertone%2C+Mark+V%3BErickson%2C+RLoren%3BMcGlynn%2C+Katherine+A&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2008-11-01&rft.volume=19&rft.issue=9&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-008-9153-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Germ cells; Genetic diversity; Tumors; Hormones; Homozygotes; Androgen receptors; Promoters; Single-nucleotide polymorphism; Heterozygotes; Introns; Cytochrome P450; seminoma; Metabolism; introns; genetic diversity; tumors; Cancer DO - http://dx.doi.org/10.1007/s10552-008-9153-6 ER - TY - JOUR T1 - Modified Escherichia coli B (BL21), a superior producer of plasmid DNA compared with Escherichia coli K (DH5a) AN - 20688960; 10247951 AB - Plasmid DNA (pDNA) is an emerging experimental vaccine, produced in E. coli, initially targeted for viral diseases. Unlike traditional protein vaccines whose average dose is micrograms, the average dose of pDNA is on the scale of milligrams. Production yields are, therefore, important for the future development of this vaccine. The E. coli strains currently used for pDNA production, JM109 and DH5, are both suitable for production of stable pDNA due to the deletion of recA and endA, however, these two E. coli K strains are sensitive to growth conditions such as high glucose concentration. On the other hand E. coli BL21 is less sensitive to growth conditions than E. coli JM109 or DH5, this strain grows to higher densities and due to its active glyoxylate shunt and anaplerotic pathways is not sensitive to high glucose concentration. This strain is used for recombinant protein production but not for pDNA production because of its inability to produce stable pDNA. To adapt E. coli BL21 for stable pDNA production, the strain was mutated by deleting both recA and endA, and a proper growth and production strategy was developed. Production values, reaching 2 g/L were obtained using glucose as a carbon source. The produced plasmid, which was constructed for HIV clinical study, was found to have identical properties to the plasmid currently produced by E. coli DH5. Biotechnol. Bioeng. 2008; 101: 831-836. JF - Biotechnology and Bioengineering AU - Phue, Je-Nie AU - Lee, Sang Jun AU - Trinh, Loc AU - Shiloach, Joseph AD - Biotechnology Core Laboratory, NIDDK NIH Bethesda, Bldg 14A Room 173, Maryland 20892; 301-451-5911, yossi@nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 831 EP - 836 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 101 IS - 4 SN - 0006-3592, 0006-3592 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Human immunodeficiency virus KW - Growth conditions KW - Shunts KW - Escherichia coli KW - Glucose KW - DNA KW - Anaplerotic pathways KW - Vaccines KW - Carbon sources KW - Plasmids KW - RecA protein KW - V 22360:AIDS and HIV KW - J 02320:Cell Biology KW - N 14845:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20688960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Modified+Escherichia+coli+B+%28BL21%29%2C+a+superior+producer+of+plasmid+DNA+compared+with+Escherichia+coli+K+%28DH5a%29&rft.au=Phue%2C+Je-Nie%3BLee%2C+Sang+Jun%3BTrinh%2C+Loc%3BShiloach%2C+Joseph&rft.aulast=Phue&rft.aufirst=Je-Nie&rft.date=2008-11-01&rft.volume=101&rft.issue=4&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/10.1002%2Fbit.21973 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Growth conditions; Shunts; DNA; Glucose; Anaplerotic pathways; Carbon sources; Vaccines; Plasmids; RecA protein; Human immunodeficiency virus; Escherichia coli DO - http://dx.doi.org/10.1002/bit.21973 ER - TY - JOUR T1 - Variation in lung cancer risk by smoky coal subtype in Xuanwei, China AN - 20626269; 9355885 AB - Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age (±2 years) and sex to examine risk by coal subtype. Odds ratios (ORs) and 95% confidence intervals (CIs) for coal subtype were calculated by conditional logistic regression, adjusting for potential confounders. Overall, smoky coal use was positively and statistically significantly associated with lung cancer risk, when compared with the use of smokeless coal or wood (OR = 7.7, 95% CI = 4.5-13.3). Furthermore, there was a marked heterogeneity in risk estimates for specific subtypes of smoky coal (test for heterogeneity: p = 5.17 X 10-10). Estimates were highest for coal of the Laibin (OR = 24.8, 95% CI = 12.4-49.6) and Longtan (OR = 11.6, 95% CI = 5.0-27.2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Lan, Qing AU - He, Xingzhou AU - Shen, Min AU - Tian, Linwei AU - Liu, Larry Z AU - Lai, Hong AU - Chen, Wei AU - Berndt, Sonja I AU - Hosgood, Howard Dean AU - Lee, Kyoung-Mu AU - Zheng, Tongzhang AU - Blair, Aaron AU - Chapman, Robert S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, qingl@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 2164 EP - 2169 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 9 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Age KW - Carcinogenicity KW - Combustion products KW - Emissions KW - Wood KW - polycyclic aromatic hydrocarbons KW - China, People's Rep. KW - Coal KW - Mines KW - Cancer KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20626269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Variation+in+lung+cancer+risk+by+smoky+coal+subtype+in+Xuanwei%2C+China&rft.au=Lan%2C+Qing%3BHe%2C+Xingzhou%3BShen%2C+Min%3BTian%2C+Linwei%3BLiu%2C+Larry+Z%3BLai%2C+Hong%3BChen%2C+Wei%3BBerndt%2C+Sonja+I%3BHosgood%2C+Howard+Dean%3BLee%2C+Kyoung-Mu%3BZheng%2C+Tongzhang%3BBlair%2C+Aaron%3BChapman%2C+Robert+S&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2008-11-01&rft.volume=123&rft.issue=9&rft.spage=2164&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23748 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Combustion products; Carcinogenicity; Emissions; polycyclic aromatic hydrocarbons; Wood; Coal; Mines; Cancer; Lung cancer; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.23748 ER - TY - JOUR T1 - Rosiglitazone, a PPAR gamma agonist: Potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers AN - 20626030; 9355898 AB - In an initial study to determine if rosiglitazone had chemopreventive activity, Fischer-344 female rats were administered twice weekly doses of hydroxybutyl(butyl)nitrosamine (OH-BBN), a urinary bladder specific carcinogen, for 8 weeks. Two weeks following the last dose of OH-BBN, rats were administered rosiglitazone (50 mg/kg BW) daily by gavage for the remainder of the study (7 months). Only 57% of OH-BBN-treated animals developed palpable urinary bladder cancers during the course of the study, while all of the OH-BBN plus rosiglitazone treated rats developed large cancers (p < 0.01). Surprisingly, examination for PPAR gamma by immunohistochemistry in the urinary bladders of rats showed that while untreated bladder urothelium and preneoplastic lesions clearly expressed PPAR gamma, frank carcinomas exhibited significantly lower levels. This was confirmed by employing microarray studies of the same samples. In additional studies, lower doses of rosiglitazone (10, 2 and 0.4 mg/kg BW/day) were administered. The 10 mg/kg BW/day dose greatly enhanced bladder cancer incidence (p < 0.01). The dose of 2 mg/kg BW/day, which is roughly equivalent to a standard human dose, also significantly increased bladder cancer incidence (controls, 48%; rosiglitazone-treated, 84%). The lowest dose did not significantly increase tumor incidence (rosiglitazone at 0.4 mg/kg BW/day, 64%) or tumor weight in the rats, although there was a trend in that direction. Rosiglitazone alone (10 mg/kg BW/day) given in the absence of OH-BBN did not result in bladder cancer formation when given for 10 months. In summary, rosiglitazone over a wide dose range enhanced urinary bladder carcinogenesis in the OH-BBN model in rats. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Lubet, Ronald A AU - Fischer, Susan M AU - Steele, Vernon E AU - Juliana, M Margaret AU - Desmond, Renee' AU - Grubbs, Clinton J AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, lubetr@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 2254 EP - 2259 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 10 SN - 0020-7136, 0020-7136 KW - Toxicology Abstracts KW - Promoters KW - Peroxisome proliferator-activated receptors KW - Urinary bladder KW - Carcinogenesis KW - urothelium KW - Tumors KW - Carcinogens KW - rosiglitazone KW - Immunohistochemistry KW - Cancer KW - Carcinoma KW - X 24500:Reviews, Legislation, Book & Conference Notices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20626030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Rosiglitazone%2C+a+PPAR+gamma+agonist%3A+Potent+promoter+of+hydroxybutyl%28butyl%29nitrosamine-induced+urinary+bladder+cancers&rft.au=Lubet%2C+Ronald+A%3BFischer%2C+Susan+M%3BSteele%2C+Vernon+E%3BJuliana%2C+M+Margaret%3BDesmond%2C+Renee%27%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2008-11-01&rft.volume=123&rft.issue=10&rft.spage=2254&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Promoters; Peroxisome proliferator-activated receptors; Urinary bladder; Carcinogenesis; urothelium; Carcinogens; Tumors; Immunohistochemistry; rosiglitazone; Cancer; Carcinoma DO - http://dx.doi.org/10.1002/ijc.23765 ER - TY - JOUR T1 - Low Bone Mineral Density and Mortality in Men and Women: The Third National Health and Nutrition Examination Survey Linked Mortality File AN - 20562401; 9272936 AB - Purpose The aim of this study is to determine the association of bone mineral density and mortality over a median follow-up of 9 years. Methods The baseline data used are from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of non-institutionalized civilians. A cohort of 5,769 non-Hispanic whites, non-Hispanic blacks, and Mexican Americans aged 50 years and older at baseline (1988-1994) was followed through 2000 for overall mortality using the restricted-use NHANES III Linked Mortality File (1,741 deaths). Total proximal femoral bone mineral density was measured by dual-energy x-ray absorptiometry and categorized into quartiles. Cox proportional hazards models were used to estimate the relative risk of death after adjusting for multiple risk factors. Results Compared with subjects in the highest quartile of bone mineral density, those in the lowest quartile had greater risk of death (relative risk, 1.53; 95% confidence interval: 1.08-2.18; P = 0.02). There was no significant interaction of bone mineral density with race or ethnicity. Conclusion Low bone mineral density was associated with increased risk of death. Key Words: Bone Density; Follow-up Studies; Longitudinal Studies; Mortality; Proportional Hazards Models; Men; Women Abbreviations: BMD, bone mineral density; NHANES III, Third National Health and Nutrition Examination Survey; DXA, dual energy x-ray absorptiometry; RR, relative risk; CI, confidence interval JF - Annals of Epidemiology AU - Mussolino, Michael E AU - Gillummd, R F AD - Centers for Disease Control and Prevention, National Center for Health Statistics, Hyattsville, Md, mussolinom@nhlbi.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 847 EP - 850 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 11 SN - 1047-2797, 1047-2797 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Mortality KW - Data processing KW - Dual energy X-ray absorptiometry KW - males KW - Nutrition KW - Femur KW - Models KW - Bone mineral density KW - Risk factors KW - bone density KW - Females KW - bone mineral density KW - Minerals KW - longitudinal studies KW - Ethnic groups KW - Races KW - R2 23060:Medical and environmental health KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20562401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Low+Bone+Mineral+Density+and+Mortality+in+Men+and+Women%3A+The+Third+National+Health+and+Nutrition+Examination+Survey+Linked+Mortality+File&rft.au=Mussolino%2C+Michael+E%3BGillummd%2C+R+F&rft.aulast=Mussolino&rft.aufirst=Michael&rft.date=2008-11-01&rft.volume=18&rft.issue=11&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2008.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Bone mineral density; Risk factors; Dual energy X-ray absorptiometry; Femur; Nutrition; Races; Ethnic groups; Models; bone density; males; Females; Minerals; bone mineral density; longitudinal studies DO - http://dx.doi.org/10.1016/j.annepidem.2008.07.003 ER - TY - JOUR T1 - Radiation Dose to the Brain and Subsequent Risk of Developing Brain Tumors in Pediatric Patients Undergoing Interventional Neuroradiology Procedures AN - 20265122; 8904586 AB - Thierry-Chef, I., Simon, S. L., Land, C. E. and Miller, D. L. Radiation Dose to the Brain and Subsequent Risk of Developing Brain Tumors in Pediatric Patients Undergoing Interventional Neuroradiology Procedures. Radiat. Res. 170, 553- 565 (2008). Radiation dose to the brain and subsequent lifetime risk of diagnosis of radiation-related brain tumors were estimated for pediatric patients undergoing intracranial embolization. Average dose to the whole brain was calculated using dosimetric data from the Radiation Doses in Interventional Radiology Study for 49 pediatric patients who underwent neuroradiological procedures, and lifetime risk of developing radiation-related brain tumors was estimated using published algorithms based on A-bomb survivor data. The distribution of absorbed dose within the brain can vary significantly depending on field size and movement during procedures. Depending on the exposure conditions and age of the patient, organ-averaged brain dose was estimated to vary from 6 to 1600 mGy. The lifetime risk of brain tumor diagnosis was estimated to be increased over the normal background rates (57 cases per 10,000) by 3 to 40% depending on the dose received, age at exposure, and gender. While significant uncertainties are associated with these estimates, we have quantified the range of possible dose and propagated the uncertainty to derive a credible range of estimated lifetime risk for each subject. Collimation and limiting fluoroscopy time and dose rate are the most effective means to minimize dose and risk of future induction of radiation-related tumors. JF - Radiation Research AU - Thierry-Chef, I AU - Simon, S L AU - Land, CE AU - Miller, D L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; , thierrychefi@iarc.fr Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 553 EP - 565 PB - Radiation Research Society VL - 170 IS - 5 SN - 0033-7587, 0033-7587 KW - Biotechnology and Bioengineering Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Age KW - Algorithms KW - Radiation KW - Embolization KW - Data processing KW - Pediatrics KW - Radiology KW - Brain tumors KW - fluoroscopy KW - X 24390:Radioactive Materials KW - N3 11027:Neurology & neuropathology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20265122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Radiation+Dose+to+the+Brain+and+Subsequent+Risk+of+Developing+Brain+Tumors+in+Pediatric+Patients+Undergoing+Interventional+Neuroradiology+Procedures&rft.au=Thierry-Chef%2C+I%3BSimon%2C+S+L%3BLand%2C+CE%3BMiller%2C+D+L&rft.aulast=Thierry-Chef&rft.aufirst=I&rft.date=2008-11-01&rft.volume=170&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1393.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Brain tumors; Radiation; Pediatrics; Data processing; Age; fluoroscopy; Algorithms; Embolization; Radiology DO - http://dx.doi.org/10.1667/RR1393.1 ER - TY - JOUR T1 - Prospective Analysis of Traffic Exposure as a Risk Factor for Incident Coronary (Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study AN - 20239740; 8763878 AB - Background: For people living dose to busy roads, traffic is a major source of air pollution. Few prospective data have been published on the effects of long-term exposure to traffic on the incidence of coronary heart disease (CHD). Objectives: In this article, we examined the association between long-term traffic exposure and incidence of fetal and nonfatal CHD in a population-based prospective cohort study. Methods: We studied 13,309 middle-age men and women in the Atherosclerosis Risk in Communities study, without previous CHD at enrollment, from 1987 to 1989 in four U.S. communities. Geographic information system-mapped traffic density and distance to major roads served as measures of traffic exposure. We examined the association between traffic exposure and incident CHD using proportional hazards regression models, with adjustment for background air pollution and a wide range of individual cardiovascular risk factors. Results: Over an average of 13 years of follow-up, 976 subjects developed CHD. Relative to those in the lowest quartile of traffic density, the adjusted hazard ratio (HR) in the highest quartile was 1.32 [95% confidence interval (CI), 1.06-1.65; p-value for trend across quartiles = 0.042]. When we treated traffic density as a continuous variable, the adjusted HR per one unit increase of log-transformed density was 1.03 (95% CI, 1.01-1.05; P= 0.006). For residents living within 300 m of major roads compared with those living farther away, the adjusted HR was 1.12 (95% CI, 0.95-1.32; p = 0.189). We found little evidence of effect modification for sex, smoking status, obesity, low-density lipoprotein cholesterol level, hypertension, age, or education. Conclusion: Higher long-term exposure to traffic is associated with incidence of CHD, independent of other risk factors. These prospective data support an effect of traffic-related air pollution on the development of CHD in middle-age persons. JF - Environmental Health Perspectives AU - Kan, H AU - Heiss, G AU - Rose, K M AU - Whitsel, E A AU - Lurmann, F AU - London, S J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop A3-05, Research Triangle Park, NC 27709 USA, london2@mehs.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1463 EP - 1468 VL - 116 IS - 11 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Environment Abstracts KW - Age KW - obesity KW - Pollution effects KW - Arteriosclerosis KW - Models KW - Smoking KW - Risk factors KW - Regression analysis KW - Obesity KW - Data processing KW - Cholesterol KW - cholesterol KW - Fetuses KW - Coronary heart disease KW - Traffic KW - Air pollution KW - USA KW - Education KW - traffic KW - hypertension KW - Lipoproteins KW - Cardiovascular diseases KW - Information systems KW - Hypertension KW - X 24380:Social Poisons & Drug Abuse KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Prospective+Analysis+of+Traffic+Exposure+as+a+Risk+Factor+for+Incident+Coronary+%28Heart+Disease%3A+The+Atherosclerosis+Risk+in+Communities+%28ARIC%29+Study&rft.au=Kan%2C+H%3BHeiss%2C+G%3BRose%2C+K+M%3BWhitsel%2C+E+A%3BLurmann%2C+F%3BLondon%2C+S+J&rft.aulast=Kan&rft.aufirst=H&rft.date=2008-11-01&rft.volume=116&rft.issue=11&rft.spage=1463&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11290 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Obesity; Age; Data processing; Cholesterol; Arteriosclerosis; Coronary heart disease; Fetuses; Traffic; Models; Air pollution; Smoking; Risk factors; Lipoproteins; Regression analysis; Cardiovascular diseases; Hypertension; Information systems; obesity; Pollution effects; cholesterol; Education; traffic; hypertension; USA DO - http://dx.doi.org/10.1289/ehp.11290 ER - TY - JOUR T1 - Development of optimal bicistronic lentiviral vectors facilitates high- level TCR gene expression and robust tumor cell recognition AN - 20054172; 8570610 AB - In human gene therapy applications, lentiviral vectors may have advantages over [gamma]-retroviral vectors in several areas, including the ability to transduce nondividing cells, resistance to gene silencing and a potentially safer integration site profile. However, unlike [gamma]- retroviral vectors it has been problematic to drive the expression of multiple genes efficiently and coordinately with approaches such as internal ribosome entry sites or dual promoters. Using different 2A peptides, lentiviral vectors expressing two-gene T-cell receptors directed against the melanoma differentiation antigens gp100 and MART-1 were constructed. We demonstrated that addition of amino-acid spacer sequences (GSG or SGSG) before the 2A sequence is a prerequisite for efficient synthesis of biologically active T-cell receptors and that addition of a furin cleavage site followed by a V5 peptide tag yielded optimal T-cell receptor gene expression. Furthermore, we determined that the furin cleavage site was recognized in lymphocytes and accounted for removal of residual 2A peptides at the post-translational level with an efficiency of 20-30%, which could not be increased by addition of multiple furin cleavage sites. The novel bicistronic lentiviral vector developed herein afforded robust anti-melanoma activities to engineered peripheral blood lymphocytes, including cytokine secretion, cell proliferation and lytic activity. Such optimal vectors may have immediate applications in cancer gene therapy. JF - Gene Therapy AU - Yang, S AU - Cohen, C J AU - Peng, P D AU - Zhao, Y AU - Cassard, L AU - Yu, Z AU - Zheng, Z AU - Jones, S AU - Restifo, N P AU - Rosenberg, S A AU - Morgan, R A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, rmorgan@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1411 EP - 1423 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 21 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - T-cell receptor KW - adoptive immunotherapy KW - tumor immunity KW - lentivirus KW - 2A peptide KW - Gene therapy KW - Spacer KW - Peripheral blood KW - Lymphocytes KW - Tumor cells KW - Cancer KW - furin KW - Melanoma KW - Expression vectors KW - Promoters KW - Differentiation KW - Integration KW - MART-1 antigen KW - Post-translation KW - Antigen (tumor-associated) KW - Glycoprotein gp100 KW - Cytokines KW - Internal ribosome entry site KW - Cell proliferation KW - Gene silencing KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - V 22350:Immunology KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20054172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Development+of+optimal+bicistronic+lentiviral+vectors+facilitates+high-+level+TCR+gene+expression+and+robust+tumor+cell+recognition&rft.au=Yang%2C+S%3BCohen%2C+C+J%3BPeng%2C+P+D%3BZhao%2C+Y%3BCassard%2C+L%3BYu%2C+Z%3BZheng%2C+Z%3BJones%2C+S%3BRestifo%2C+N+P%3BRosenberg%2C+S+A%3BMorgan%2C+R+A&rft.aulast=Yang&rft.aufirst=S&rft.date=2008-11-01&rft.volume=15&rft.issue=21&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2008.90 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - T-cell receptor; Gene therapy; Peripheral blood; Spacer; Lymphocytes; Tumor cells; Cancer; Melanoma; furin; Expression vectors; Integration; Differentiation; Promoters; MART-1 antigen; Post-translation; Glycoprotein gp100; Antigen (tumor-associated); Internal ribosome entry site; Cytokines; Cell proliferation; Gene silencing DO - http://dx.doi.org/10.1038/gt.2008.90 ER - TY - JOUR T1 - Genetic Control of Variegated KIR Gene Expression: Polymorphisms of the Bi-Directional KIR3DL1 Promoter Are Associated with Distinct Frequencies of Gene Expression AN - 19917152; 8819488 AB - Natural killer (NK) cells play an important role in the detection and elimination of tumors and virus-infected cells by the innate immune system. Human NK cells use cell surface receptors (KIR) for class I MHC to sense alterations of class I on potential target cells. Individual NK cells only express a subset of the available KIR genes, generating specialized NK cells that can specifically detect alteration of a particular class I molecule or group of molecules. The probabilistic behavior of human KIR bi-directional promoters is proposed to control the frequency of expression of these variegated genes. Analysis of a panel of donors has revealed the presence of several functionally relevant promoter polymorphisms clustered mainly in the inhibitory KIR family members, especially the KIR3DL1 alleles. We demonstrate for the first time that promoter polymorphisms affecting the strength of competing sense and antisense promoters largely explain the differential frequency of expression of KIR3DL1 allotypes on NK cells. KIR3DL1/S1 subtypes have distinct biological activity and coding region variants of the KIR3DL1/S1 gene strongly influence pathogenesis of HIV/AIDS and other human diseases. We propose that the polymorphisms shown in this study to regulate the frequency of KIR3DL1/S1 subtype expression on NK cells contribute substantially to the phenotypic variation across allotypes with respect to disease resistance. Author Summary Natural killer (NK) cells represent a specialized blood cell that plays an important role in the detection of virus-infected or cancer cells. NK cells recognize and kill diseased cells using receptors for self antigens (HLA) that are frequently altered on aberrant cells. The HLA receptors are known as Killer cell Immunoglobulin-like Receptors, or KIR. Humans possess from four to 14 KIR receptor genes in their genome, and individual NK cells express a subset of the available KIR genes, generating specialized NK cells that detect alterations in specific HLA proteins. The mechanism of this unusual selective gene activation was recently shown by our group to be controlled by a probabilistic bi-directional promoter switch that turns on a given gene at a pre-determined frequency in the NK cell population. The current study shows that the properties of the switches in terms of the relative activity of forward (on) versus reverse (off) promoter activity is directly correlated with the frequency at which a given gene is expressed within the NK cell population. These results have important implications for our understanding of the role of NK cells in viral resistance and bone marrow transplants. JF - PLoS Genetics AU - Li, Hongchuan AU - Pascal, Veronique AU - Martin, Maureen P AU - Carrington, Mary AU - Anderson, Stephen K AU - Roopenian, Derry C AD - Basic Research Program, SAIC-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 4 IS - 11 SN - 1553-7390, 1553-7390 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Histocompatibility antigen HLA KW - Genomes KW - Cell surface KW - Acquired immune deficiency syndrome KW - Gene polymorphism KW - Immune system KW - Major histocompatibility complex KW - Disease resistance KW - Gene expression KW - Promoters KW - Antisense KW - Potassium channels (inwardly-rectifying) KW - Blood cells KW - Bone marrow transplantation KW - Natural killer cells KW - Allotypes KW - Tumors KW - KIR protein KW - Autoantigens KW - Cancer KW - Human immunodeficiency virus KW - Killer cell immunoglobulin-like receptors KW - Genetic control KW - Transcription activation KW - S1 gene KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19917152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Genetics&rft.atitle=Genetic+Control+of+Variegated+KIR+Gene+Expression%3A+Polymorphisms+of+the+Bi-Directional+KIR3DL1+Promoter+Are+Associated+with+Distinct+Frequencies+of+Gene+Expression&rft.au=Li%2C+Hongchuan%3BPascal%2C+Veronique%3BMartin%2C+Maureen+P%3BCarrington%2C+Mary%3BAnderson%2C+Stephen+K%3BRoopenian%2C+Derry+C&rft.aulast=Li&rft.aufirst=Hongchuan&rft.date=2008-11-01&rft.volume=4&rft.issue=11&rft.spage=e1000254&rft.isbn=&rft.btitle=&rft.title=PLoS+Genetics&rft.issn=15537390&rft_id=info:doi/10.1371%2Fjournal.pgen.1000254 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Histocompatibility antigen HLA; Cell surface; Acquired immune deficiency syndrome; Immune system; Gene polymorphism; Natural killer cells; Major histocompatibility complex; Allotypes; Disease resistance; Tumors; Cancer; Autoantigens; KIR protein; Gene expression; Promoters; Antisense; Potassium channels (inwardly-rectifying); Killer cell immunoglobulin-like receptors; Genetic control; Blood cells; Transcription activation; Bone marrow transplantation; S1 gene; Human immunodeficiency virus DO - http://dx.doi.org/10.1371/journal.pgen.1000254 ER - TY - JOUR T1 - Discovery of Pituitary Adenylate Cyclase-Activating Polypeptide-Regulated Genes through Microarray Analyses in Cell Culture and In Vivo AN - 19899032; 8822907 AB - Pituitary adenylate cyclase-activating polypeptide (PACAP) is an evolutionarily well conserved neuropeptide with multiple functions in the nervous, endocrine, and immune systems. PACAP provides neuroprotection from ischemia and toxin exposure, is anti-inflammatory in gastric inflammatory disease and sepsis, controls proliferative signaling pathways involved in neural cell transformation, and modulates glucohomeostasis. PACAP-based, disease-targeted therapeutics might thus be both effective and benign, enhancing homeostatic responses to behavioral, metabolic, oncogenic, and inflammatory stressors. PACAP signal transduction employs synergistic regulation of calcium and cyclic adenosine monophosphate (cAMP), and noncanonical activation of both calcium- and cAMP-dependent processes. Pharmacological activation of PACAP signaling should consequently have highly specific effects even in vivo. Here, a combined cellular biochemical, pharmacologic, transcriptomic, and bioinformatic approach to understanding PACAP signal transduction by identifying PACAP target genes with oligonucleotide- and cDNA-based microarray is described. Calcium- and cAMP-dependent PACAP signaling pathways for regulation of genes encoding proteins required for neuritogenesis, changes in cell morphology, and cell survival have been traced in PC12 cells. Pharmacological experiments have linked gene expression to cell physiological responses in this system, in which gene silencing can also be employed to confirm the functional significance of induction of specific transcripts. Differential transcriptional responses to metabolic, ischemic, and other stressors in wild type compared to PACAP-deficient mice establish in principle which PACAP-responsive transcripts in culture are PACAP-dependent in vivo. Bioinformatic approaches aid in creating a pipeline for identifying neuropeptide-regulated genes, validating their cellular functions, and defining their expression in the context of neuropeptide signaling physiology, required for discovery of new targets for drug action. JF - Annals of the New York Academy of Sciences AU - Eiden, Lee E AU - Samal, Babru AU - Gerdin, Matthew J AU - Mustafa, Tomris AU - Vaudry, David AU - Stroth, Nikolas AD - Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, NIMH-IRP, National Institutes of Health, Bethesda, Maryland, USA, eidenl@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 6 EP - 20 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1144 IS - 1 SN - 0077-8923, 0077-8923 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Calcium & Calcified Tissue Abstracts KW - bioinformatics KW - gene discovery KW - microarray KW - neuropeptide KW - neuroprotection KW - PACAP KW - PC12 KW - pituitary adenylate cyclase-activating polypeptide KW - signal transduction KW - stress response KW - Transformation KW - Cell survival KW - Calcium KW - Immune system KW - Neuroprotection KW - Cell culture KW - DNA microarrays KW - Pituitary adenylate cyclase-activating polypeptide KW - Pheochromocytoma cells KW - Inflammatory diseases KW - Cytology KW - Axonogenesis KW - Neuropeptides KW - Drugs KW - Benign KW - Cyclic AMP KW - Transcription KW - Ischemia KW - Toxins KW - Inflammation KW - Sepsis KW - Gene regulation KW - Bioinformatics KW - Evolution KW - Signal transduction KW - Gene silencing KW - T 2000:Cellular Calcium KW - N3 11001:Behavioral and Cognitive Neuroscience KW - J 02350:Immunology KW - G 07730:Development & Cell Cycle KW - N 14810:Methods KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19899032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Discovery+of+Pituitary+Adenylate+Cyclase-Activating+Polypeptide-Regulated+Genes+through+Microarray+Analyses+in+Cell+Culture+and+In+Vivo&rft.au=Eiden%2C+Lee+E%3BSamal%2C+Babru%3BGerdin%2C+Matthew+J%3BMustafa%2C+Tomris%3BVaudry%2C+David%3BStroth%2C+Nikolas&rft.aulast=Eiden&rft.aufirst=Lee&rft.date=2008-11-01&rft.volume=1144&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1418.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Transformation; Calcium; Immune system; Cell culture; Neuroprotection; DNA microarrays; Pituitary adenylate cyclase-activating polypeptide; Pheochromocytoma cells; Inflammatory diseases; Axonogenesis; Cytology; Drugs; Neuropeptides; Benign; Cyclic AMP; Transcription; Ischemia; Toxins; Inflammation; Sepsis; Gene regulation; Bioinformatics; Evolution; Gene silencing; Signal transduction DO - http://dx.doi.org/10.1196/annals.1418.019 ER - TY - JOUR T1 - BEI Resources: Supporting antiviral research AN - 19879304; 8578964 AB - The Biodefense and Emerging Infections Research Resources Repository (BEI Resources) provides unique, quality-assured reagents to the scientific community for use in basic research and product development involving biodefense and emerging infectious diseases. These include microorganisms (up to Biosafety Level-3) on the National Institute of Allergy and Infectious Diseases (NIAID) and Centers for Disease Control and Prevention (CDC) lists of Category A, B and C priority pathogens. In addition to live microorganisms, related products such as polyclonal antisera, monoclonal antibodies, isolated nucleic acid preparations, overlapping peptide arrays, purified proteins, and assay kits are also available. Many of these materials have direct or indirect applications in antiviral research. These reagents are available free of charge to all registered investigators, regardless of funding source or affiliation. Acquisition of new reagents for the repository is one of the critically necessary and challenging tasks for BEI Resources. Therefore, investigators are encouraged to deposit relevant items, so as to provide access to materials, relief from the burden of distribution, protection of intellectual property rights, and secure storage. In addition, BEI Resources has the capability of contracting for the preparation of specific reagents. If there is a resource needed to advance a specific research area, contact an NIAID program officer or use the ''suggest a reagent'' option on the BEI Resources homepage, www.beiresources.org. JF - Antiviral Research AU - Baker, R AU - Peacock, S AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States, peacocksusan@niaid.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 102 EP - 106 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 80 IS - 2 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Deposits KW - Antisera KW - Hypersensitivity KW - nucleic acids KW - Infectious diseases KW - intellectual property KW - Monoclonal antibodies KW - Microorganisms KW - Disease control KW - Pathogens KW - Infection KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19879304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=BEI+Resources%3A+Supporting+antiviral+research&rft.au=Baker%2C+R%3BPeacock%2C+S&rft.aulast=Baker&rft.aufirst=R&rft.date=2008-11-01&rft.volume=80&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2008.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Deposits; Hypersensitivity; Antisera; nucleic acids; intellectual property; Infectious diseases; Monoclonal antibodies; Disease control; Microorganisms; Pathogens; Infection DO - http://dx.doi.org/10.1016/j.antiviral.2008.07.003 ER - TY - JOUR T1 - Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity AN - 19803751; 8590973 AB - Genome endoreduplication during mammalian development is a rare event for which the mechanism is unknown. It first appears when fibroblast growth factor 4 (FGF4) deprivation induces differentiation of trophoblast stem (TS) cells into the nonproliferating trophoblast giant (TG) cells required for embryo implantation. Here we show that RO3306 inhibition of cyclin-dependent protein kinase 1 (CDK1), the enzyme required to enter mitosis, induced differentiation of TS cells into TG cells. In contrast, RO3306 induced abortive endoreduplication and apoptosis in embryonic stem cells, revealing that inactivation of CDK1 triggers endoreduplication only in cells programmed to differentiate into polyploid cells. Similarly, FGF4 deprivation resulted in CDK1 inhibition by overexpressing two CDK-specific inhibitors, p57/KIP2 and p21/CIP1. TS cell mutants revealed that p57 was required to trigger endoreduplication by inhibiting CDK1, while p21 suppressed expression of the checkpoint protein kinase CHK1, thereby preventing induction of apoptosis. Furthermore, Cdk2 super(-/-) TS cells revealed that CDK2 is required for endoreduplication when CDK1 is inhibited. Expression of p57 in TG cells was restricted to G-phase nuclei to allow CDK activation of S phase. Thus, endoreduplication in TS cells is triggered by p57 inhibition of CDK1 with concomitant suppression of the DNA damage response by p21. JF - Genes & Development AU - Ullah, Zakir AU - Kohn, Matthew J AU - Yagi, Rieko AU - Vassilev, Lyubomir T AU - DePamphilis, Melvin L AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Ajinomoto Institute of Life Science, Kawasaki 210-8681, Japan. Department of Discovery Oncology, Roche Research Center, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110, USA Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 3024 EP - 3036 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 22 IS - 21 SN - 0890-9369, 0890-9369 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Protein kinase C KW - Endoreduplication KW - Giant cells KW - Genomes KW - Polyploidy KW - Apoptosis KW - Enzymes KW - Trophoblasts KW - DNA damage KW - Differentiation KW - Fibroblast growth factor 4 KW - Stem cells KW - Embryo cells KW - Cyclin-dependent kinase KW - S phase KW - Mitosis KW - Protein kinase KW - Nuclei KW - Cyclin-dependent kinase 2 KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19803751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Differentiation+of+trophoblast+stem+cells+into+giant+cells+is+triggered+by+p57%2FKip2+inhibition+of+CDK1+activity&rft.au=Ullah%2C+Zakir%3BKohn%2C+Matthew+J%3BYagi%2C+Rieko%3BVassilev%2C+Lyubomir+T%3BDePamphilis%2C+Melvin+L&rft.aulast=Ullah&rft.aufirst=Zakir&rft.date=2008-11-01&rft.volume=22&rft.issue=21&rft.spage=3024&rft.isbn=&rft.btitle=&rft.title=Genes+%26+Development&rft.issn=08909369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Giant cells; Endoreduplication; Protein kinase C; Apoptosis; Polyploidy; Trophoblasts; Enzymes; Differentiation; DNA damage; Stem cells; Fibroblast growth factor 4; Cyclin-dependent kinase; Embryo cells; S phase; Mitosis; Protein kinase; Cyclin-dependent kinase 2; Nuclei ER - TY - JOUR T1 - Relationship of p53 Overexpression on Cancers and Recognition by Anti-p53 T Cell Receptor-Transduced T Cells AN - 19800736; 8852252 AB - Tumor suppressor p53 is reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in inactivation and often an accumulation of the protein in the tumor cells. Only low amounts of protein are detectable in normal tissues. The differential display of antigen in normal versus tumor tissues has been reported to create an opportunity to target p53 by immunotherapy. We sought to determine the relationship between p53 expression and its recognition by cognate T cells in human tumors including common epithelial malignancies. Inasmuch as nonsense or missense p53 mutations may disrupt processing and presentation, we studied tumors with either identified wild-type or mutated p53, based on our gene-sequencing studies or published data. T cells transduced with a high-affinity, p53 sub(264-272)-reactive T cell receptor (TCR) derived from HLA-A2.1 transgenic mice recognized a wide panel of human tumor lines. There was no significant correlation between p53 expression in tumors and recognition by the anti-p53 TCR-transduced T cells. This conclusion was based on the study of 48 cell lines and is in contrast to several prior studies that used only a limited number of selected cell lines. A panel of normal cells was evaluated for recognition, and some of these populations were capable of stimulating anti-p53 T cells, albeit at low levels. These studies raise doubts concerning the suitability of targeting p53 in the immunotherapy of cancer patients. JF - Human Gene Therapy AU - Theoret, M R AU - Cohen, C J AU - Nahvi, A V AU - Ngo, L T AU - Suri, K B AU - Powell, DJ Jr AU - Dudley, ME AU - Morgan, R A AU - Rosenberg, SA AD - Surgery Branch, Building 10-CRC, Room 3W3-3940, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC 1201, Bethesda, MD 20892-1201, USA, sar@nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1219 EP - 1231 VL - 19 IS - 11 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Histocompatibility antigen HLA KW - Tumor suppressor genes KW - Data processing KW - Gene therapy KW - Immunotherapy KW - double prime T-cell receptor KW - Tumors KW - Transgenic mice KW - Tumor cells KW - Cancer KW - p53 protein KW - Malignancy KW - Lymphocytes T KW - Mutation KW - Differential display KW - W 30905:Medical Applications KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19800736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Relationship+of+p53+Overexpression+on+Cancers+and+Recognition+by+Anti-p53+T+Cell+Receptor-Transduced+T+Cells&rft.au=Theoret%2C+M+R%3BCohen%2C+C+J%3BNahvi%2C+A+V%3BNgo%2C+L+T%3BSuri%2C+K+B%3BPowell%2C+DJ+Jr%3BDudley%2C+ME%3BMorgan%2C+R+A%3BRosenberg%2C+SA&rft.aulast=Theoret&rft.aufirst=M&rft.date=2008-11-01&rft.volume=19&rft.issue=11&rft.spage=1219&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.083 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Tumor suppressor genes; Data processing; Gene therapy; double prime T-cell receptor; Immunotherapy; Tumors; Transgenic mice; Tumor cells; Cancer; p53 protein; Malignancy; Lymphocytes T; Mutation; Differential display DO - http://dx.doi.org/10.1089/hum.2008.083 ER - TY - JOUR T1 - Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus AN - 19749647; 8607731 AB - Exosomes have been proposed as candidates for therapeutic immunization. The present study demonstrates that incorporation of the G protein of vesicular stomatitis virus (VSV-G) into exosome-like vesicles (ELVs) enhances their uptake and induces the maturation of dendritic cells. Targeting of VSV- G and ovalbumin as a model antigen to the same ELVs increased the cross- presentation of ovalbumin via an endosomal acidification mechanism. Immunization of mice with VSV-G and ovalbumin containing ELVs led to an increased IgG2a antibody response, expansion of antigen-specific CD8 T cells, strong in vivo CTL responses, and protection from challenge with ovalbumin expressing tumor cells. Thus, incorporation of VSV-G and targeting of antigens to ELVs are attractive strategies to improve exosomal vaccines. JF - Vaccine AU - Temchura, Vladimir V AU - Tenbusch, Matthias AU - Nchinda, Godwin AU - Nabi, Ghulam AU - Tippler, Bettina AU - Zelenyuk, Maryna AU - Wildner, Oliver AU - Uberla, Klaus AU - Kuate, Seraphin AD - Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum D-44780, Germany, kuates@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 3662 EP - 3672 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 48 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Exosomes KW - VSV-G KW - Vaccines KW - Ovalbumin KW - exosomes KW - Animal models KW - CD8 antigen KW - Antibody response KW - Antigen presentation KW - Tumor cells KW - Immunization KW - Dendritic cells KW - Cytotoxicity KW - Immunostimulation KW - Lymphocytes T KW - Immunoglobulin G KW - Vesicles KW - Acidification KW - Vesicular stomatitis virus KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19749647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Enhancement+of+immunostimulatory+properties+of+exosomal+vaccines+by+incorporation+of+fusion-competent+G+protein+of+vesicular+stomatitis+virus&rft.au=Temchura%2C+Vladimir+V%3BTenbusch%2C+Matthias%3BNchinda%2C+Godwin%3BNabi%2C+Ghulam%3BTippler%2C+Bettina%3BZelenyuk%2C+Maryna%3BWildner%2C+Oliver%3BUberla%2C+Klaus%3BKuate%2C+Seraphin&rft.aulast=Temchura&rft.aufirst=Vladimir&rft.date=2008-11-01&rft.volume=26&rft.issue=48&rft.spage=3662&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.04.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ovalbumin; exosomes; Animal models; Antibody response; CD8 antigen; Antigen presentation; Tumor cells; Immunization; Dendritic cells; Cytotoxicity; Immunostimulation; Immunoglobulin G; Lymphocytes T; Vesicles; Vaccines; Acidification; Vesicular stomatitis virus DO - http://dx.doi.org/10.1016/j.vaccine.2008.04.069 ER - TY - JOUR T1 - Evaluation of systemic and mucosal anti-HPV16 and anti-HPV18 antibody responses from vaccinated women AN - 19743623; 8607721 AB - Ideal methods to monitor HPV neutralizing antibodies induced by vaccination have not been established yet. Here, we evaluated systemic and cervical antibody levels induced by HPV16/18 AS04-adjuvanted vaccine (GlaxoSmithKline Biologicals) using a secreted alkaline phosphatase neutralization assay (SEAP-NA) and enzyme-linked immunosorbent assay (ELISA). Serum and cervical secretions from 50 vaccinated women were used to assess (1) overall assay reproducibility; (2) inter-assay and inter-specimen correlation; (3) correlations between month 1 and month 12 titers. Strong correlations between SEAP-NA and ELISA were observed (serum anti-HPV16/18, [rho] = 0.91/0.85; cervix anti-HPV16/18, [rho] = 0.84/0.89). Systemic and cervical antibody measures also correlated well ([rho] range: 0.64- 0.75); except at mid-cycle ([rho] range: 0.28-0.65). Correlations between antibody levels at 1 and 12 months following the start of vaccination were poor ([rho] range: 0.16-0.38). In conclusion, HPV16/18 VLP-based ELISA is a reliable and valid method to monitor anti-HPV16/18 neutralizing potential for the first year following vaccination; however, additional studies will be required to better define the effects of the time on cycle and patterns of antibody response over time following vaccination. JF - Vaccine AU - Kemp, Troy J AU - Garcia-Pineres, Alfonso AU - Falk, Roni T AU - Poncelet, Sylviane AU - Dessy, Francis AU - Giannini, Sandra L AU - Rodriguez, Ana Cecilia AU - Porras, Carolina AU - Herrero, Rolando AU - Hildesheim, Allan AU - Pinto, Ligia A AD - HPV Immunology Laboratory, SAIC-Frederick Inc., NCI-Frederick, Building 469, Room 120, Frederick, MD 21702, USA, lpinto@ncifcrf.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 3608 EP - 3616 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 48 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Human papillomavirus KW - Neutralization assay KW - Cervical secretions KW - Enzyme-linked immunosorbent assay KW - Alkaline phosphatase KW - Human papillomavirus 16 KW - Secretions KW - Mucosa KW - Vaccines KW - Antibody response KW - Cervix KW - Vaccination KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19743623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Evaluation+of+systemic+and+mucosal+anti-HPV16+and+anti-HPV18+antibody+responses+from+vaccinated+women&rft.au=Kemp%2C+Troy+J%3BGarcia-Pineres%2C+Alfonso%3BFalk%2C+Roni+T%3BPoncelet%2C+Sylviane%3BDessy%2C+Francis%3BGiannini%2C+Sandra+L%3BRodriguez%2C+Ana+Cecilia%3BPorras%2C+Carolina%3BHerrero%2C+Rolando%3BHildesheim%2C+Allan%3BPinto%2C+Ligia+A&rft.aulast=Kemp&rft.aufirst=Troy&rft.date=2008-11-01&rft.volume=26&rft.issue=48&rft.spage=3608&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.04.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Alkaline phosphatase; Mucosa; Secretions; Antibody response; Vaccines; Cervix; Vaccination; Human papillomavirus 16 DO - http://dx.doi.org/10.1016/j.vaccine.2008.04.074 ER - TY - JOUR T1 - Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence AN - 19688116; 8598011 AB - Rationale: Cocaine users have increased regional brain mu-opioid receptor (mOR) binding which correlates with cocaine craving. The relationship of mOR binding to relapse is unknown. Objective: To evaluate regional brain mOR binding as a predictor of relapse to cocaine use is the objective of the study. Materials and methods: Fifteen nontreatment-seeking, adult cocaine users were housed on a closed research ward for 12 weeks of monitored abstinence and then followed for up to 1 year after discharge. Regional brain mOR binding was measured after 1 and 12 weeks using positron emission tomography (PET) with [ super(11)C]carfentanil (a selective mOR agonist). Time to first cocaine use (lapse) and to first two consecutive days of cocaine use (relapse) after discharge was based on self-report and urine toxicology. Results: A shorter interval before relapse was associated with increased mOR binding in frontal and temporal cortical regions at 1 and 12 weeks of abstinence (Ps < 0.001) and with a lesser decrease in binding between 1 and 12 weeks (Ps < 0.0008). There were significant positive correlations between mOR binding at 12 weeks and percent days of cocaine use during first month after relapse (Ps < 0.002). In multiple linear regression analysis, mOR binding contributed significantly to the prediction of time to relapse (R super(2 )= 0.79, P < 0.001), even after accounting for clinical variables. Conclusions: Increased brain mOR binding in frontal and temporal cortical regions is a significant independent predictor of time to relapse to cocaine use, suggesting an important role for the brain endogenous opioid system in cocaine addiction. JF - Psychopharmacology AU - Gorelick, David A AU - Kim, Yu Kyeong AU - Bencherif, Badreddine AU - Boyd, Susan J AU - Nelson, Richard AU - Copersino, Marc L AU - Dannals, Robert F AU - Frost, JJames AD - NIDA IRP, 251 Bayview Boulevard, suite 200, Baltimore, 21224, MD, USA, dgorelic@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 475 EP - 486 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 200 IS - 4 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Cortex KW - Urine KW - Brain KW - Positron emission tomography KW - Regression analysis KW - Opioid receptors (type mu) KW - Opioids KW - Addiction KW - Cocaine KW - Drug abuse KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19688116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Brain+mu-opioid+receptor+binding%3A+relationship+to+relapse+to+cocaine+use+after+monitored+abstinence&rft.au=Gorelick%2C+David+A%3BKim%2C+Yu+Kyeong%3BBencherif%2C+Badreddine%3BBoyd%2C+Susan+J%3BNelson%2C+Richard%3BCopersino%2C+Marc+L%3BDannals%2C+Robert+F%3BFrost%2C+JJames&rft.aulast=Gorelick&rft.aufirst=David&rft.date=2008-11-01&rft.volume=200&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-008-1225-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cortex; Urine; Regression analysis; Positron emission tomography; Brain; Opioids; Opioid receptors (type mu); Addiction; Drug abuse; Cocaine DO - http://dx.doi.org/10.1007/s00213-008-1225-5 ER - TY - JOUR T1 - A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial AN - 19686569; 8685532 AB - Background - The severe acute respiratory syndrome (SARS) virus is a member of the Coronaviridae (CoV) family that first appeared in the Guangdong Province of China in 2002 and was recognized as an emerging infectious disease in March 2003. Over 8000 cases and 900 deaths occurred during the epidemic. We report the safety and immunogenicity of a SARS DNA vaccine in a Phase I human study. Methods - A single-plasmid DNA vaccine encoding the Spike (S) glycoprotein was evaluated in 10 healthy adults. Nine subjects completed the 3 dose vaccination schedule and were evaluated for vaccine safety and immune responses. Immune response was assessed by intracellular cytokine staining (ICS), ELISpot, ELISA, and neutralization assays. Results - The vaccine was well tolerated. SARS-CoV-specific antibody was detected by ELISA in 8 of 10 subjects and neutralizing antibody was detected in all subjects who received 3 doses of vaccine. SARS-CoV-specific CD4+ T-cell responses were detected in all vaccinees, and CD8+ T-cell responses in [not, vert, similar]20% of individuals. Conclusions - The VRC SARS DNA vaccine was well tolerated and produced cellular immune responses and neutralizing antibody in healthy adults. JF - Vaccine AU - Martin, Julie E AU - Louder, Mark K AU - Holman, LaSonji A AU - Gordon, Ingelise J AU - Enama, Mary E AU - Larkin, Brenda D AU - Andrews, Charla A AU - Vogel, Leatrice AU - Koup, Richard A AU - Roederer, Mario AU - Bailer, Robert T AU - Gomez, Phillip L AU - Nason, Martha AU - Mascola, John R AU - Nabel, Gary J AU - Graham, Barney S AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, MSC-2610, Bethesda, MD 20892-3017, USA, bgraham@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 6338 EP - 6343 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 50 SN - 0264-410X, 0264-410X KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - T-cell vaccine KW - Emerging infectious disease KW - Vaccine clinical trial KW - vaccines KW - clinical trials KW - Clinical trials KW - China, People's Rep., Guangdong Prov. KW - CD4 antigen KW - Infectious diseases KW - DNA vaccines KW - Lymphocytes T KW - Cytokines KW - Glycoproteins KW - Neutralization KW - Mortality KW - Enzyme-linked immunosorbent assay KW - Epidemics KW - Coronaviridae KW - severe acute respiratory syndrome KW - Severe acute respiratory syndrome KW - immunogenicity KW - CD8 antigen KW - glycoproteins KW - Antibodies KW - Immunogenicity KW - DNA KW - Immune response KW - SARS coronavirus KW - V 22350:Immunology KW - H 1000:Occupational Safety and Health KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=A+SARS+DNA+vaccine+induces+neutralizing+antibody+and+cellular+immune+responses+in+healthy+adults+in+a+Phase+I+clinical+trial&rft.au=Martin%2C+Julie+E%3BLouder%2C+Mark+K%3BHolman%2C+LaSonji+A%3BGordon%2C+Ingelise+J%3BEnama%2C+Mary+E%3BLarkin%2C+Brenda+D%3BAndrews%2C+Charla+A%3BVogel%2C+Leatrice%3BKoup%2C+Richard+A%3BRoederer%2C+Mario%3BBailer%2C+Robert+T%3BGomez%2C+Phillip+L%3BNason%2C+Martha%3BMascola%2C+John+R%3BNabel%2C+Gary+J%3BGraham%2C+Barney+S&rft.aulast=Martin&rft.aufirst=Julie&rft.date=2008-11-01&rft.volume=26&rft.issue=50&rft.spage=6338&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.09.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Epidemics; Severe acute respiratory syndrome; CD8 antigen; Clinical trials; Antibodies; CD4 antigen; DNA vaccines; Infectious diseases; Immunogenicity; Lymphocytes T; Cytokines; Glycoproteins; Immune response; glycoproteins; Mortality; vaccines; severe acute respiratory syndrome; immunogenicity; DNA; clinical trials; Neutralization; Coronaviridae; SARS coronavirus; China, People's Rep., Guangdong Prov. DO - http://dx.doi.org/10.1016/j.vaccine.2008.09.026 ER - TY - JOUR T1 - The Changing Face of Biomedical Research in Tuberculosis AN - 19617388; 8604316 AB - Tuberculosis (TB) remains a significant cause of morbidity and mortality despite improvements in detection and treatment. Current global control strategies are not sufficient to significantly affect TB rates worldwide and are unlikely to meet global targets without new diagnostic tests, drugs, and vaccines. Increasing rates of drug-resistant TB coupled with co-infection in people with HIV infection, threaten to reverse gains made in controlling both diseases. Control of TB includes many interconnected components. NIH/NIAID supports fundamental, translational, and clinical TB studies and provides resources to facilitate research on candidate products. In an era of limited government funding, clinical use of candidate products, and a changing landscape of organizations participating in TB research and development, it is critical to re-evaluate each partner's contributions. This rethinking will ensure that limited resources focus on medical gaps, and tasks are undertaken by the most suitable organizations. Collaborative efforts are essential to advance in TB research and development. JF - Clinical Microbiology Newsletter AU - Ph.D., Christine Sizemore AU - Ph.D., Carole Heilman AD - Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, csizemore@niaid.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 167 EP - 171 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 30 IS - 22 SN - 0196-4399, 0196-4399 KW - Microbiology Abstracts B: Bacteriology KW - Translation KW - Mortality KW - Human immunodeficiency virus KW - Mycobacterium KW - Drug resistance KW - Landscape KW - Tuberculosis KW - Vaccines KW - Infection KW - Drugs KW - Morbidity KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19617388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=The+Changing+Face+of+Biomedical+Research+in+Tuberculosis&rft.au=Ph.D.%2C+Christine+Sizemore%3BPh.D.%2C+Carole+Heilman&rft.aulast=Ph.D.&rft.aufirst=Christine&rft.date=2008-11-01&rft.volume=30&rft.issue=22&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/10.1016%2Fj.clinmicnews.2008.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Translation; Drug resistance; Landscape; Tuberculosis; Vaccines; Infection; Drugs; Morbidity; Mycobacterium; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.clinmicnews.2008.10.002 ER - TY - JOUR T1 - Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish AN - 19589693; 8781718 AB - An enhancer within intron 1 of the amyloid precursor protein gene (APPb) of zebrafish is identified functionally using a novel approach. Bacterial artificial chromosomes (BACs) were retrofitted with enhancer traps, and expressed as transgenes in zebrafish. Expression from both transient assays and stable lines were used for analysis. Although the enhancer was active in specific nonneural cells of the notochord when placed with APPb gene promoter proximal elements its function was restricted to, and absolutely required for, specific expression in neurons when juxtaposed with additional far-upstream promoter elements of the gene. We demonstrate that expression of green fluorescent protein fluorescence resembling the tissue distribution of APPb mRNA requires both the intron 1 enhancer and similar to 28 kb of DNA upstream of the gene. The results indicate that tissue-specificity of an isolated enhancer may be quite different from that in the context of its own gene. Using this enhancer and upstream sequence, polymorphic variants of APPb can now more closely recapitulate the endogenous pattern and regulation of APPb expression in animal models for Alzheimer's disease. The methodology should help functionally map multiple noncontiguous regulatory elements in BACs with or without gene-coding sequences. JF - Nucleic Acids Research AU - Shakes, Leighcraft A AU - Malcolm, Tennison L AU - Allen, Kevin L AU - De, Supriyo AU - Harewood, Ken R AU - Chatterjee, Pradeep K AD - 1 Julius L. Chambers Biomedical/Biotechnology Research Institute, 2 Department of Chemistry, 3 Department of Biology, North Carolina Central University, Durham, NC 27707 and 4 Gene Expression and Genomics Unit, National Institute on Aging, NIH, Triad Technology Center, Baltimore, MD 21224, USA, pchatterjee@nccu.edu Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 6237 EP - 6248 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - 19 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Nucleotide sequence KW - Alzheimer's disease KW - Animal models KW - Green fluorescent protein KW - Freshwater KW - Freshwater fish KW - Promoters KW - Chromosomes KW - Fluorescence KW - Regulatory sequences KW - Biopolymorphism KW - mRNA KW - Amyloid precursor protein KW - Bacterial artificial chromosomes KW - Danio rerio KW - Enhancers KW - Neurodegenerative diseases KW - Neurons KW - Introns KW - DNA KW - Notochord KW - Traps KW - Nucleic acids KW - J 02310:Genetics & Taxonomy KW - W 30925:Genetic Engineering KW - N3 11023:Neurogenetics KW - Q1 08484:Species interactions: parasites and diseases KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19589693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Context+dependent+function+of+APPb+enhancer+identified+using+enhancer+trap-containing+BACs+as+transgenes+in+zebrafish&rft.au=Shakes%2C+Leighcraft+A%3BMalcolm%2C+Tennison+L%3BAllen%2C+Kevin+L%3BDe%2C+Supriyo%3BHarewood%2C+Ken+R%3BChatterjee%2C+Pradeep+K&rft.aulast=Shakes&rft.aufirst=Leighcraft&rft.date=2008-11-01&rft.volume=36&rft.issue=19&rft.spage=6237&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn628 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Promoters; Chromosomes; Neurons; Nucleotide sequence; DNA; Biopolymorphism; Freshwater fish; Nucleic acids; Fluorescence; Regulatory sequences; Alzheimer's disease; Green fluorescent protein; Animal models; Amyloid precursor protein; mRNA; Bacterial artificial chromosomes; Neurodegenerative diseases; Enhancers; Introns; Traps; Notochord; Danio rerio; Freshwater DO - http://dx.doi.org/10.1093/nar/gkn628 ER - TY - JOUR T1 - Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease AN - 19589064; 8822893 AB - Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but glutamate has since been shown to regulate neurogenesis, neurite outgrowth, synaptogenesis, and neuron survival in the developing and adult mammalian nervous system. Cell-surface glutamate receptors are coupled to Ca super(2+) influx and release from endoplasmic reticulum stores, which causes rapid (kinase- and protease-mediated) and delayed (transcription-dependent) responses that change the structure and function of neurons. Neurotrophic factors and glutamate interact to regulate developmental and adult neuroplasticity. For example, glutamate stimulates the production of brain-derived neurotrophic factor (BDNF), which, in turn, modifies neuronal glutamate sensitivity, Ca super(2+) homeostasis, and plasticity. Neurotrophic factors may modify glutamate signaling directly, by changing the expression of glutamate receptor subunits and Ca super(2+)-regulating proteins, and also indirectly by inducing the production of antioxidant enzymes, energy-regulating proteins, and antiapoptotic Bcl-2 family members. Excessive activation of glutamate receptors, under conditions of oxidative and metabolic stress, may contribute to neuronal dysfunction and degeneration in diseases ranging from stroke and Alzheimer's disease to psychiatric disorders. By enhancing neurotrophic factor signaling, environmental factors such as exercise and dietary energy restriction, and chemicals such as antidepressants may optimize glutamatergic signaling and protect against neurological disorders. JF - Annals of the New York Academy of Sciences AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA, mattsonm@grc.nia.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 97 EP - 112 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1144 IS - 1 SN - 0077-8923, 0077-8923 KW - Sustainability Science Abstracts; Calcium & Calcified Tissue Abstracts; CSA Neurosciences Abstracts KW - Cell survival KW - Alzheimer's disease KW - Endoplasmic reticulum KW - stroke KW - Nervous system KW - Structure-function relationships KW - antidepressants KW - Degeneration KW - Bcl-2 protein KW - Neurotransmitters KW - Diets KW - environmental factors KW - Transcription KW - Stress KW - Glutamic acid receptors KW - Physical training KW - survival KW - mental disorders KW - Chemicals KW - Plasticity (developmental) KW - Neurological diseases KW - Antioxidants KW - Plasticity (neural) KW - Environmental factors KW - Mental disorders KW - Calcium influx KW - Neurogenesis KW - Synaptogenesis KW - Axonogenesis KW - Brain-derived neurotrophic factor KW - Calcium homeostasis KW - Stroke KW - Neurotrophic factors KW - Enzymes KW - Antidepressants KW - Neurodegenerative diseases KW - Proteins KW - Signal transduction KW - N3 11001:Behavioral and Cognitive Neuroscience KW - M3 1010:Issues in Sustainable Development KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19589064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Glutamate+and+Neurotrophic+Factors+in+Neuronal+Plasticity+and+Disease&rft.au=Mattson%2C+Mark+P&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2008-11-01&rft.volume=1144&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1418.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Proteins; Chemicals; Alzheimer's disease; Diets; environmental factors; survival; Antioxidants; Stress; Enzymes; antidepressants; stroke; mental disorders; Glutamic acid receptors; Neurotrophic factors; Neurogenesis; Signal transduction; Brain-derived neurotrophic factor; Cell survival; Synaptogenesis; Calcium influx; Neurotransmitters; Axonogenesis; Plasticity (neural); Neurodegenerative diseases; Stroke; Neurological diseases; Calcium homeostasis; Structure-function relationships; Plasticity (developmental); Antidepressants; Endoplasmic reticulum; Physical training; Degeneration; Bcl-2 protein; Mental disorders; Transcription; Nervous system; Environmental factors DO - http://dx.doi.org/10.1196/annals.1418.005 ER - TY - JOUR T1 - Estimation of particle mass concentration in ambient air using a particle counter AN - 19586700; 8678311 AB - Particle count may have advantage over particle mass concentration for assessing the health effects of airborne particulate matter. However, health effects have mainly been investigated with mass-measuring instruments, so it is important to assess relationships between the variability of particle number, as determined by an optical particle counter, and the variability of particle mass as measured by traditional mass-measuring instruments. We used a light scattering particle counter to monitor the concentration of particulate matter in ambient air in a northern Italian city continuously from August 2005 to July 2006. Six channels were calibrated to count particles in the size range 0.3-10 mu m and above. Particles under 0.3 mu m cannot be detected by the instrument. The particle counter was placed alongside the mass-measuring instruments of the Environmental Protection Agency of the Region of Piemonte (ARPA). Particle numbers were transformed into masses and compared with PM sub(1) sub(0) and PM sub(2) sub(.) sub(5) data obtained from the ARPA instruments. Daily average values were compared. The correlation between the two methods was good for both PM sub(1) sub(0) (R super(2)=0.734) and PM sub(2) sub(.) sub(5) (R super(2)=0.856); differences between means were significant only for PM sub(2) sub(.) sub(5). These findings suggest that a light scattering particle counter might be suitable for assessing particulate matter variability in epidemiological studies on effects of air pollution, though further investigations are necessary. JF - Atmospheric Environment AU - Tittarelli, A AU - Borgini, A AU - Bertoldi, M AU - De Saeger, E AU - Ruprecht, A AU - Stefanoni, R AU - Tagliabue, G AU - Contiero, P AU - Crosignani, P AD - National Cancer Institute, Via Venezian 1, 20133 Milano, Italy, andrea.tittarelli@istitutotumori.mi.it Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 8543 EP - 8548 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 42 IS - 36 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Atmospheric pollution variations KW - Light scattering KW - Correlations KW - Particulate matter in urban air KW - Particulates KW - Particulate matter in atmosphere KW - particle counters KW - Urban areas KW - Particle size KW - Atmospheric pollution KW - Italy, Piemonte KW - Atmospheric pollution effects KW - Particulate atmospheric pollution KW - Environmental protection KW - Channels KW - Air pollution KW - EPA KW - Urban atmospheric pollution KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19586700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Estimation+of+particle+mass+concentration+in+ambient+air+using+a+particle+counter&rft.au=Tittarelli%2C+A%3BBorgini%2C+A%3BBertoldi%2C+M%3BDe+Saeger%2C+E%3BRuprecht%2C+A%3BStefanoni%2C+R%3BTagliabue%2C+G%3BContiero%2C+P%3BCrosignani%2C+P&rft.aulast=Tittarelli&rft.aufirst=A&rft.date=2008-11-01&rft.volume=42&rft.issue=36&rft.spage=8543&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2008.07.056 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution variations; Particulate matter in atmosphere; Atmospheric pollution; Correlations; Atmospheric pollution effects; Light scattering; Urban atmospheric pollution; Particulate matter in urban air; Particulate atmospheric pollution; Environmental protection; Air pollution; Channels; Particle size; EPA; Particulates; particle counters; Urban areas; Italy, Piemonte DO - http://dx.doi.org/10.1016/j.atmosenv.2008.07.056 ER - TY - JOUR T1 - Sex Partner Type and Condom Use in African American Adolescent Mothers: A Literature Review AN - 19562244; 8783581 AB - PROBLEM:Teen mothers may need mental health counseling that goes beyond addressing the parenting stressors of motherhood to include those related to sexual risk decision-making. Sexual risk behaviors of adolescent girls are influenced by partner type. Coparent, 'baby's daddy' partner types may exert unique psychosocial influences on their sexual risk decisions and, thus, their risk for human immunodeficiency virus infection. METHODS:A review of literature was conducted to identify, critique, and summarize the research on partner-type influences on the sexual risk decision-making of African American adolescent mothers. Extensive searches of PubMed, CINAHL, MEDLINE, PsycINFO, and CRISP were conducted. Data displays were constructed to compare constructs across studies. Both the strengths and limitations of these studies are highlighted. FINDINGS:Most studies on partner types and sexual behavior are quantitative, and few target adolescent mothers. Only four studies were identified that focused on sexual partner influences on condom use in African American adolescent mothers, with only one examining the coparent as a partner type. No published studies were identified that examined adolescent mothers' reasons for making partner-specific sexual risk decisions or choices made in regard to having sex with their 'babies' daddies.' CONCLUSION:The state of the science is inadequate regarding partner-type influences on the sexual risk decisions of African American adolescent mothers. Further research is vital for mental healthcare providers so that the depth and complexity of partner-related influences on sexual risk decisions can be appropriately addressed during risk assessments and counseling. JF - Journal of Child & Adolescent Psychiatric Nursing AU - Nelson, LaRon E AU - Morrison-Beedy, Dianne AD - Monroe County Department of Public Health, Rochester, NY, and NIH/NINR Pre-Doctoral Fellow, Center for High Risk Children and Youth, University of Rochester School of Nursing, Rochester, NY, lnelson@monroecounty.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 213 EP - 219 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 21 IS - 4 SN - 1073-6077, 1073-6077 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Adolescent mothers KW - African American KW - condom use KW - decision-making KW - HIV KW - HIV prevention KW - partner type KW - review of literature KW - state of the science KW - Risk assessment KW - sexual behavior KW - Data processing KW - Adolescence KW - Infection KW - Sexual behavior KW - Medical personnel KW - Condoms KW - Sexual partners KW - Decision making KW - Mental disorders KW - Human immunodeficiency virus KW - Reviews KW - Nursing KW - condoms KW - infection KW - Africa KW - mental disorders KW - Adolescents KW - Ethnic groups KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19562244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+%26+Adolescent+Psychiatric+Nursing&rft.atitle=Sex+Partner+Type+and+Condom+Use+in+African+American+Adolescent+Mothers%3A+A+Literature+Review&rft.au=Nelson%2C+LaRon+E%3BMorrison-Beedy%2C+Dianne&rft.aulast=Nelson&rft.aufirst=LaRon&rft.date=2008-11-01&rft.volume=21&rft.issue=4&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+%26+Adolescent+Psychiatric+Nursing&rft.issn=10736077&rft_id=info:doi/10.1111%2Fj.1744-6171.2008.00140.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sexual partners; Risk assessment; Condoms; Decision making; Mental disorders; Data processing; Nursing; Reviews; Adolescence; Infection; Sexual behavior; sexual behavior; infection; condoms; mental disorders; Medical personnel; Ethnic groups; Adolescents; Human immunodeficiency virus; Africa DO - http://dx.doi.org/10.1111/j.1744-6171.2008.00140.x ER - TY - JOUR T1 - Transient Exposure to Transforming Growth Factor Beta 3 Under Serum-Free Conditions Enhances the Biomechanical and Biochemical Maturation of Tissue-Engineered Cartilage AN - 19512613; 8833721 AB - A goal of cartilage tissue engineering is the production of cell-laden constructs possessing sufficient mechanical and biochemical features to enable native tissue function. This study details a systematic characterization of a serum-free (SF) culture methodology employing transient growth factor supplementation to promote robust maturation of tissue-engineered cartilage. Bovine chondrocyte agarose hydrogel constructs were cultured under free-swelling conditions in serum-containing or SF medium supplemented continuously or transiently with varying doses of transforming growth factor beta 3 (TGF- beta 3). Constructs were harvested weekly or bi-weekly and assessed for mechanical and biochemical properties. Transient exposure (2 weeks) to low concentrations (2.5-5 ng/mL) of TGF- beta 3 in chemically defined medium facilitated robust and highly reproducible construct maturation. Constructs receiving transient TGF- beta 3 exposure achieved native tissue levels of compressive modulus (0.8 MPa) and proteoglycan content (6-7% of wet weight) after less than 2 months of in vitro culture. This maturation response was far superior to that observed after continuous growth factor supplementation or transient TGF- beta 3 treatment in the presence of serum. These findings represent a significant advance in developing an ex vivo culture methodology to promote production of clinically relevant and mechanically competent tissue-engineered cartilage constructs for implantation to repair damaged articular surfaces. JF - Tissue Engineering, Part A: Tissue Engineering AU - Byers, BA AU - Mauck, R L AU - Chiang, I E AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 50 South Drive, Building 50, Room 1503, MSC 8022, Bethesda, MD 20892, USA, tuanr@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1821 EP - 1834 VL - 14 IS - 11 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Proteoglycans KW - hydrogels KW - Cartilage KW - Chondrocytes KW - Transforming growth factor-^b KW - Cell culture KW - Tissue engineering KW - Supplementation KW - Transforming growth factor-^b1 KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19512613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Transient+Exposure+to+Transforming+Growth+Factor+Beta+3+Under+Serum-Free+Conditions+Enhances+the+Biomechanical+and+Biochemical+Maturation+of+Tissue-Engineered+Cartilage&rft.au=Byers%2C+BA%3BMauck%2C+R+L%3BChiang%2C+I+E%3BTuan%2C+R+S&rft.aulast=Byers&rft.aufirst=BA&rft.date=2008-11-01&rft.volume=14&rft.issue=11&rft.spage=1821&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2007.0222 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tissue engineering; Transforming growth factor-^b; Cartilage; Cell culture; Transforming growth factor-^b1; Supplementation; Proteoglycans; Chondrocytes; hydrogels DO - http://dx.doi.org/10.1089/ten.tea.2007.0222 ER - TY - JOUR T1 - Age-Dependent Demise of GNAS-Mutated Skeletal Stem Cells and "Normalization" of Fibrous Dysplasia of Bone AN - 19492974; 8614008 AB - We studied the role of somatic mosaicism in fibrous dysplasia of bone (FD) within the context of skeletal ("mesenchymal") stem cells by assessing the frequency of mutated colony forming unit-fibroblasts (CFU-Fs) from FD lesions, and in some cases, from unaffected sites, in a series of patients. There was a tight inverse correlation between the percentage mutant CFU-F versus age, suggesting demise of mutant stem cells caused by exuberant apoptosis noted in samples from young patients. In older patients, either partially or completely normal bone/marrow histology was observed. On in vivo transplantation, FD ossicles were generated only by cell strains in which mutant CFU-Fs were identified. Strains that lacked mutant CFU-F (but were mutation positive) failed to regenerate an FD ossicle. These data indicate that GNAS mutations are only pathogenic when in clonogenic skeletal stem cells. From these data, we have evolved the novel concept of "normalization" of FD. As a lesion ages, mutant stem cells fail to self-renew, and their progeny are consumed by apoptosis, whereas residual normal stem cells survive, self-renew, and enable formation of a normal structure. This suggests that activating GNAS mutations disrupt a pathway that is required for skeletal stem cell self-renewal. JF - Journal of Bone and Mineral Research AU - Kuznetsov, SA AU - Cherman, N AU - Riminucci, M AU - Collins, M T AU - Robey, P G AU - Bianco, P AD - CSDB/NIDCR/NIH/DHHS, 30 Convent Drive, MSC 4320, Building 30, Room 228, Bethesda, MD 20892, USA, probey@dir.nidcr.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1731 EP - 1740 VL - 23 IS - 11 SN - 0884-0431, 0884-0431 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Age KW - Data processing KW - Apoptosis KW - Bone marrow KW - Bone dysplasia KW - Fibrous dysplasia KW - Stem cells KW - Colonies KW - Mosaicism KW - Progeny KW - Mesenchyme KW - Mutation KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19492974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bone+and+Mineral+Research&rft.atitle=Age-Dependent+Demise+of+GNAS-Mutated+Skeletal+Stem+Cells+and+%22Normalization%22+of+Fibrous+Dysplasia+of+Bone&rft.au=Kuznetsov%2C+SA%3BCherman%2C+N%3BRiminucci%2C+M%3BCollins%2C+M+T%3BRobey%2C+P+G%3BBianco%2C+P&rft.aulast=Kuznetsov&rft.aufirst=SA&rft.date=2008-11-01&rft.volume=23&rft.issue=11&rft.spage=1731&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/10.1359%2FJBMR.080609 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Colonies; Age; Stem cells; Apoptosis; Data processing; Mosaicism; Bone marrow; Progeny; Mesenchyme; Bone dysplasia; Mutation; Fibrous dysplasia DO - http://dx.doi.org/10.1359/JBMR.080609 ER - TY - JOUR T1 - Reverse-phase protein lysate microarrays for cell signaling analysis AN - 19411048; 8758434 AB - 'Reverse-phase' protein lysate microarray (RPA) assays use micro-scale, cell lysate dot blots that are printed to a substrate, followed by quantitative immunochemical protein detection, known to be particularly effective across many samples. Large-scale sample collection is a labor- intensive and time-consuming process; the information yielded from RPA assays, however, provides unique opportunities to experimentally interpret theoretical protein networks quantitatively. When specific antibodies are used, RPA can generate 1,000 times more data points using 10,000 times less sample volume than an ordinary western blot, enabling researchers to monitor quantitative proteomic responses for various time-scale and input-dose gradients simultaneously. Hence, the RPA system can be an excellent method for experimental validation of theoretical protein network models. Besides the initial screening of primary antibodies, collection of several hundreds of sample lysates from 1- to 8-h periods can be completed in [math]10 d; subsequent RPA printing and signal detection steps require an additional 2-3 d. JF - Nature Protocols AU - Spurrier, Brett AU - Ramalingam, Sundhar AU - Nishizuka, Satoshi AD - Molecular Translational Technology Section, Molecular Therapeutics Program, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA., snishizu@iwate-med.ac.jp Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1796 EP - 1808 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 11 SN - 1754-2189, 1754-2189 KW - Biotechnology and Bioengineering Abstracts KW - Biochemistry and protein analysis KW - Cell and developmental biology KW - Immunological techniques KW - Western blotting KW - Antibodies KW - Data processing KW - Printing KW - Information processing KW - Protein arrays KW - proteomics KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19411048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Reverse-phase+protein+lysate+microarrays+for+cell+signaling+analysis&rft.au=Spurrier%2C+Brett%3BRamalingam%2C+Sundhar%3BNishizuka%2C+Satoshi&rft.aulast=Spurrier&rft.aufirst=Brett&rft.date=2008-11-01&rft.volume=3&rft.issue=11&rft.spage=1796&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.179 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Western blotting; Antibodies; Printing; Data processing; Information processing; Protein arrays; proteomics; Signal transduction DO - http://dx.doi.org/10.1038/nprot.2008.179 ER - TY - JOUR T1 - Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates AN - 19336000; 8686571 AB - A flexible, trifunctional poly(ethylene glycol)-succinamide-Lysine- Lysine-maleimide (PEG-SU-Lys-Lys-mal) linker was employed to simultaneously allow biotin tagging and cell-surface targeting through an integrin alpha sub(4) beta sub(1)-binding peptidomimetic that was regiospecifically conjugated to an IgG1-derived Fc fragment with an engineered C-terminal selenocysteine residue. The resulting antibody derivative mediates Fc receptor binding by virtue of the Fc protein and selectively targets cancer cells expressing human integrin alpha sub(4) beta sub(1). The PEG-SU-Lys-Lys-mal linker may have general utility as an organic tether for the construction of antibody-drug conjugates. JF - Bioorganic and Medicinal Chemistry AU - Thomas, Joshua D AU - Hofer, Thomas AU - Rader, Christoph AU - Burke, Terrence R AD - Laboratory of Medicinal Chemistry, CCR, NCI, NIH, Frederick, MD 21702, USA, tburke@helix.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 5785 EP - 5788 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 21 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Fc KW - Antibodies KW - double prime Fc receptors KW - Integrins KW - Hybrids KW - peptidomimetics KW - Selenocysteine KW - Biotin KW - Cancer KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19336000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Application+of+a+trifunctional+reactive+linker+for+the+construction+of+antibody-drug+hybrid+conjugates&rft.au=Thomas%2C+Joshua+D%3BHofer%2C+Thomas%3BRader%2C+Christoph%3BBurke%2C+Terrence+R&rft.aulast=Thomas&rft.aufirst=Joshua&rft.date=2008-11-01&rft.volume=18&rft.issue=21&rft.spage=5785&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2008.09.078 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fc; Antibodies; double prime Fc receptors; Integrins; Hybrids; peptidomimetics; Selenocysteine; Biotin; Cancer DO - http://dx.doi.org/10.1016/j.bmcl.2008.09.078 ER - TY - JOUR T1 - Comparison of gestational age at birth based on last menstrual period and ultrasound during the first trimester AN - 19332684; 8647980 AB - Reported last menstrual period (LMP) is commonly used to estimate gestational age (GA) but may be unreliable. Ultrasound in the first trimester is generally considered a highly accurate method of pregnancy dating. The authors compared first trimester report of LMP and first trimester ultrasound for estimating GA at birth and examined whether disagreement between estimates varied by maternal and infant characteristics. Analyses included 1867 singleton livebirths to women enrolled in a prospective pregnancy cohort. The authors computed the difference between LMP and ultrasound GA estimates (GA difference) and examined the proportion of births within categories of GA difference stratified by maternal and infant characteristics. The proportion of births classified as preterm, term and post-term by pregnancy dating methods was also examined.LMP-based estimates were 0.8 days (standard deviation=8.0, median=0) longer on average than ultrasound estimates. LMP classified more births as post-term than ultrasound (4.0% vs. 0.7%). GA difference was greater among young women, non-Hispanic Black and Hispanic women, women of non-optimal body weight and mothers of low-birthweight infants. Results indicate first trimester report of LMP reasonably approximates gestational age obtained from first trimester ultrasound, but the degree of discrepancy between estimates varies by important maternal characteristics. JF - Paediatric and Perinatal Epidemiology AU - Hoffman, Caroline S AU - Messer, Lynne C AU - Mendola, Pauline AU - Savitz, David A AU - Herring, Amy H AU - Hartmann, Katherine E AD - Department of Epidemiology,, dilworthch@niehs.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 587 EP - 596 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 22 IS - 6 SN - 0269-5022, 0269-5022 KW - Biotechnology and Bioengineering Abstracts KW - gestational age KW - measurement KW - accuracy KW - LMP KW - ultrasound estimates KW - maternal age KW - ethnic group KW - preterm KW - post-term KW - bias KW - Birth KW - Gestational age KW - Body weight KW - Dating KW - Menstruation KW - Ultrasound KW - Pregnancy KW - Infants KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19332684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paediatric+and+Perinatal+Epidemiology&rft.atitle=Comparison+of+gestational+age+at+birth+based+on+last+menstrual+period+and+ultrasound+during+the+first+trimester&rft.au=Hoffman%2C+Caroline+S%3BMesser%2C+Lynne+C%3BMendola%2C+Pauline%3BSavitz%2C+David+A%3BHerring%2C+Amy+H%3BHartmann%2C+Katherine+E&rft.aulast=Hoffman&rft.aufirst=Caroline&rft.date=2008-11-01&rft.volume=22&rft.issue=6&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Paediatric+and+Perinatal+Epidemiology&rft.issn=02695022&rft_id=info:doi/10.1111%2Fj.1365-3016.2008.00965.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Birth; Gestational age; Body weight; Dating; Menstruation; Ultrasound; Infants; Pregnancy DO - http://dx.doi.org/10.1111/j.1365-3016.2008.00965.x ER - TY - JOUR T1 - Predictors of progression in patients with Friedreich ataxia. AN - 742777714; pmid-18759347 AB - Friedreich ataxia is an inherited, progressive, neurodegenerative disorder that is clinically heterogeneous. It is caused by a trinucleotide (GAA) repeat expansion resulting in frataxin loss and oxidative stress. We assessed clinical features including the development of cardiomyopathy and scoliosis and disease progression including loss of ambulation and interference with activities of daily living relative to the length of the GAA repeat, age of onset, and age of diagnosis in a retrospective cohort study of 61 genetically confirmed patients. The use of antioxidants such as vitamins, dietary supplements, and idebenone was also examined. Linear regression and Cox proportional hazard models assessed predictors to disease milestones. The shorter GAA allele accounted for part of the variability in the age of diagnosis (46%) and less in the age of onset (27%). Multivariate analysis demonstrated that age at diagnosis, which may incorporate other genetic and environmental factors, is more important than GAA length in predicting cardiomyopathy, scoliosis, and disease progression. (c) 2008 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - La Pean, Alison AU - Jeffries, Neal AU - Grow, Chelsea AU - Ravina, Bernard AU - Di Prospero, Nicholas A AD - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892-3705, USA. lapeana@ninds.nih.gov Y1 - 2008/10/30/ PY - 2008 DA - 2008 Oct 30 SP - 2026 EP - 2032 VL - 23 IS - 14 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Young Adult KW - Cardiomyopathies -- etiology KW - Humans KW - Friedreich Ataxia -- diagnosis KW - Aged KW - Predictive Value of Tests KW - Child KW - Friedreich Ataxia -- complications KW - Multivariate Analysis KW - Child, Preschool KW - Interview, Psychological KW - Scoliosis -- etiology KW - Risk Factors KW - Adult KW - Vitamins -- administration & dosage KW - Friedreich Ataxia -- genetics KW - Confidence Intervals KW - Friedreich Ataxia -- therapy KW - Dietary Supplements KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Membrane Glycoproteins -- genetics KW - Disease Progression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742777714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Predictors+of+progression+in+patients+with+Friedreich+ataxia.&rft.au=La+Pean%2C+Alison%3BJeffries%2C+Neal%3BGrow%2C+Chelsea%3BRavina%2C+Bernard%3BDi+Prospero%2C+Nicholas+A&rft.aulast=La+Pean&rft.aufirst=Alison&rft.date=2008-10-30&rft.volume=23&rft.issue=14&rft.spage=2026&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Aggressive vs. Conservative Phototherapy for Infants with Extremely Low Birth Weight AN - 223922513; 18971491 AB - Background It is unclear whether aggressive phototherapy to prevent neurotoxic effects of bilirubin benefits or harms infants with extremely low birth weight (1000 g or less). Methods We randomly assigned 1974 infants with extremely low birth weight at 12 to 36 hours of age to undergo either aggressive or conservative phototherapy. The primary outcome was a composite of death or neurodevelopmental impairment determined for 91% of the infants by investigators who were unaware of the treatment assignments. Results Aggressive phototherapy, as compared with conservative phototherapy, significantly reduced the mean peak serum bilirubin level (7.0 vs. 9.8 mg per deciliter [120 vs. 168 μmol per liter], P<0.01) but not the rate of the primary outcome (52% vs. 55%; relative risk, 0.94; 95% confidence interval [CI], 0.87 to 1.02; P=0.15). Aggressive phototherapy did reduce rates of neurodevelopmental impairment (26%, vs. 30% for conservative phototherapy; relative risk, 0.86; 95% CI, 0.74 to 0.99). Rates of death in the aggressive-phototherapy and conservative-phototherapy groups were 24% and 23%, respectively (relative risk, 1.05; 95% CI, 0.90 to 1.22). In preplanned subgroup analyses, the rates of death were 13% with aggressive phototherapy and 14% with conservative phototherapy for infants with a birth weight of 751 to 1000 g and 39% and 34%, respectively (relative risk, 1.13; 95% CI, 0.96 to 1.34), for infants with a birth weight of 501 to 750 g. Conclusions Aggressive phototherapy did not significantly reduce the rate of death or neurodevelopmental impairment. The rate of neurodevelopmental impairment alone was significantly reduced with aggressive phototherapy. This reduction may be offset by an increase in mortality among infants weighing 501 to 750 g at birth. (ClinicalTrials.gov number, NCT00114543 .) JF - The New England Journal of Medicine AU - Morris, Brenda H, MD AU - Oh, William, MD AU - Tyson, Jon E, MD, MPH AU - Stevenson, David K, MD AU - Phelps, Dale L, MD AU - O'Shea, T Michael, MD, MPH AU - McDavid, Georgia E, RN AU - Perritt, Rebecca L, MS AU - Van Meurs, Krisa P, MD AU - Vohr, Betty R, MD AU - Grisby, Cathy, BSN AU - Yao, Qing, PhD AU - Pedroza, Claudia, PhD AU - Das, Abhik, PhD AU - Poole, W Kenneth, PhD AU - Carlo, Waldemar A, MD AU - Duara, Shahnaz, MD AU - Laptook, Abbot R, MD AU - Salhab, Walid A, MD AU - Shankaran, Seetha, MD AU - Poindexter, Brenda B, MD AU - Fanaroff, Avroy A, MD AU - Walsh, Michele C, MD AU - Rasmussen, Maynard R, MD AU - Stoll, Barbara J, MD AU - Cotten, C Michael, MD AU - Donovan, Edward F, MD AU - Ehrenkranz, Richard A, MD AU - Guillet, Ronnie, MD, PhD AU - Higgins, Rosemary D, MD Y1 - 2008/10/30/ PY - 2008 DA - 2008 Oct 30 SP - 1885 EP - 96 CY - Boston PB - Massachusetts Medical Society VL - 359 IS - 18 SN - 00284793 KW - Medical Sciences KW - Bilirubin KW - Birth weight KW - Light therapy KW - Confidence intervals KW - Birth Weight KW - Developmental Disabilities -- etiology KW - Humans KW - Bayes Theorem KW - Infant, Newborn KW - Phototherapy -- adverse effects KW - Infant Mortality KW - Hyperbilirubinemia, Neonatal -- complications KW - Developmental Disabilities -- prevention & control KW - Treatment Outcome KW - Bilirubin -- blood KW - Developmental Disabilities -- epidemiology KW - Female KW - Male KW - Infant, Extremely Low Birth Weight -- blood KW - Hyperbilirubinemia, Neonatal -- therapy KW - Phototherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223922513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Aggressive+vs.+Conservative+Phototherapy+for+Infants+with+Extremely+Low+Birth+Weight&rft.au=Morris%2C+Brenda+H%2C+MD%3BOh%2C+William%2C+MD%3BTyson%2C+Jon+E%2C+MD%2C+MPH%3BStevenson%2C+David+K%2C+MD%3BPhelps%2C+Dale+L%2C+MD%3BO%27Shea%2C+T+Michael%2C+MD%2C+MPH%3BMcDavid%2C+Georgia+E%2C+RN%3BPerritt%2C+Rebecca+L%2C+MS%3BVan+Meurs%2C+Krisa+P%2C+MD%3BVohr%2C+Betty+R%2C+MD%3BGrisby%2C+Cathy%2C+BSN%3BYao%2C+Qing%2C+PhD%3BPedroza%2C+Claudia%2C+PhD%3BDas%2C+Abhik%2C+PhD%3BPoole%2C+W+Kenneth%2C+PhD%3BCarlo%2C+Waldemar+A%2C+MD%3BDuara%2C+Shahnaz%2C+MD%3BLaptook%2C+Abbot+R%2C+MD%3BSalhab%2C+Walid+A%2C+MD%3BShankaran%2C+Seetha%2C+MD%3BPoindexter%2C+Brenda+B%2C+MD%3BFanaroff%2C+Avroy+A%2C+MD%3BWalsh%2C+Michele+C%2C+MD%3BRasmussen%2C+Maynard+R%2C+MD%3BStoll%2C+Barbara+J%2C+MD%3BCotten%2C+C+Michael%2C+MD%3BDonovan%2C+Edward+F%2C+MD%3BEhrenkranz%2C+Richard+A%2C+MD%3BGuillet%2C+Ronnie%2C+MD%2C+PhD%3BHiggins%2C+Rosemary+D%2C+MD&rft.aulast=Morris&rft.aufirst=Brenda&rft.date=2008-10-30&rft.volume=359&rft.issue=18&rft.spage=1885&rft.isbn=&rft.btitle=&rft.title=The+New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/10.1056%2FNEJMoa0803024 LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2008 Massachusetts Medical Society. All rights reserved. N1 - Last updated - 2014-03-20 N1 - CODEN - NEJMAG DO - http://dx.doi.org/10.1056/NEJMoa0803024 ER - TY - JOUR T1 - Role of HAMP domains in chemotaxis signaling by bacterial chemoreceptors AN - 20236978; 10317128 AB - Bacterial chemoreceptors undergo conformational changes in response to variations in the concentration of extracellular ligands. These changes in chemoreceptor structure initiate a series of signaling events that ultimately result in regulation of rotation of the flagellar motor. Here we have used cryo-electron tomography combined with 3D averaging to determine the in situ structure of chemoreceptor assemblies in Escherichia coli cells that have been engineered to overproduce the serine chemoreceptor Tsr. We demonstrate that chemoreceptors are organized as trimers of receptor dimers and display two distinct conformations that differ principally in arrangement of the HAMP domains within each trimer. Ligand binding and methylation alter the distribution of chemoreceptors between the two conformations, with serine binding favoring the 'expanded' conformation and chemoreceptor methylation favoring the 'compact' conformation. The distinct positions of chemoreceptor HAMP domains within the context of a trimeric unit are thus likely to represent important aspects of chemoreceptor structural changes relevant to chemotaxis signaling. Based on these results, we propose that the compact and expanded conformations represent the 'kinase-on' and 'kinase-off' states of chemoreceptor trimers, respectively. JF - Proceedings of the National Academy of Sciences, USA AU - Khursigara, Cezar M AU - Wu, Xiongwu AU - Zhang, Peijun AU - Lefman, Jonathan AU - Subramaniam, Sriram AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, ss1@nih.gov Y1 - 2008/10/28/ PY - 2008 DA - 2008 Oct 28 SP - 16555 EP - 16560 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 43 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Animal Behavior Abstracts; Chemoreception Abstracts KW - cryo-electron tomography KW - molecular architecture KW - signal transduction KW - Chemoreceptors KW - Escherichia coli KW - Tomography KW - Methylation KW - Chemotaxis KW - Serine KW - Conformation KW - Signal transduction KW - Flagella KW - R 18003:Chemotaxis KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli KW - A 01490:Miscellaneous KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20236978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Role+of+HAMP+domains+in+chemotaxis+signaling+by+bacterial+chemoreceptors&rft.au=Khursigara%2C+Cezar+M%3BWu%2C+Xiongwu%3BZhang%2C+Peijun%3BLefman%2C+Jonathan%3BSubramaniam%2C+Sriram&rft.aulast=Khursigara&rft.aufirst=Cezar&rft.date=2008-10-28&rft.volume=105&rft.issue=43&rft.spage=16555&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0806401105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Chemoreceptors; Tomography; Chemotaxis; Methylation; Serine; Flagella; Signal transduction; Conformation; Escherichia coli DO - http://dx.doi.org/10.1073/pnas.0806401105 ER - TY - CPAPER T1 - Content analysis of news coverage on the HPV vaccine T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41865844; 5065768 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Tiro, Jasmin AU - Davis, Kia AU - Bhatia, Rohini AU - Potter, Lance AU - Meissner, Helen Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41865844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Content+analysis+of+news+coverage+on+the+HPV+vaccine&rft.au=Tiro%2C+Jasmin%3BDavis%2C+Kia%3BBhatia%2C+Rohini%3BPotter%2C+Lance%3BMeissner%2C+Helen&rft.aulast=Tiro&rft.aufirst=Jasmin&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strategies that children and adolescents use to lose weight T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41862318; 5067995 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Thompson, Olivia AU - Yaroch, Amy AU - Moser, Richard AU - Atienza, Audie AU - Agurs-Collins, Tanya Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Adolescents KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41862318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Strategies+that+children+and+adolescents+use+to+lose+weight&rft.au=Thompson%2C+Olivia%3BYaroch%2C+Amy%3BMoser%2C+Richard%3BAtienza%2C+Audie%3BAgurs-Collins%2C+Tanya&rft.aulast=Thompson&rft.aufirst=Olivia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Knowledge, attitudes, and practices regarding eye health and disease among older adults: Results of a national telephone survey T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41861393; 5067019 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Ammary-Risch, Neyal AU - Scarbrough, William AU - Kwon, Harry Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Attitudes KW - Eye KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Knowledge%2C+attitudes%2C+and+practices+regarding+eye+health+and+disease+among+older+adults%3A+Results+of+a+national+telephone+survey&rft.au=Ammary-Risch%2C+Neyal%3BScarbrough%2C+William%3BKwon%2C+Harry&rft.aulast=Ammary-Risch&rft.aufirst=Neyal&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - State and local regulation of tobacco products: Lessons learned from NCI's state and community tobacco control research program T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41858395; 5068575 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Vollinger, Bob Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Tobacco KW - Research programs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=State+and+local+regulation+of+tobacco+products%3A+Lessons+learned+from+NCI%27s+state+and+community+tobacco+control+research+program&rft.au=Vollinger%2C+Bob&rft.aulast=Vollinger&rft.aufirst=Bob&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Cancer Institute's Community Network Programs to reduce cancer health disparities: A cross-site evaluation progress report T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41855153; 5070523 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Taylor, Emmanuel AU - Jenkins, Susan AU - Chu, Kenneth AU - Cooper, Leslie Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Cancer KW - Community involvement KW - Progress reports KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=National+Cancer+Institute%27s+Community+Network+Programs+to+reduce+cancer+health+disparities%3A+A+cross-site+evaluation+progress+report&rft.au=Taylor%2C+Emmanuel%3BJenkins%2C+Susan%3BChu%2C+Kenneth%3BCooper%2C+Leslie&rft.aulast=Taylor&rft.aufirst=Emmanuel&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Criminal Behavior among U.S. Black Men: Pondering the Influence of Stress, Coping and Ethnicity from a Epidemiological Criminology Perspective T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41853574; 5069321 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Hill, Carl Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Stress KW - Ethnic groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Criminal+Behavior+among+U.S.+Black+Men%3A+Pondering+the+Influence+of+Stress%2C+Coping+and+Ethnicity+from+a+Epidemiological+Criminology+Perspective&rft.au=Hill%2C+Carl&rft.aulast=Hill&rft.aufirst=Carl&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do smoking and depression during pregnancy impact risk resolution in women receiving an integrated behavioral intervention? T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41852414; 5068378 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Kiely, Michele AU - El-Khorazaty, M AU - El-Mohandes, Ayman Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Smoking KW - Pregnancy KW - Intervention KW - Depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Do+smoking+and+depression+during+pregnancy+impact+risk+resolution+in+women+receiving+an+integrated+behavioral+intervention%3F&rft.au=Kiely%2C+Michele%3BEl-Khorazaty%2C+M%3BEl-Mohandes%2C+Ayman&rft.aulast=Kiely&rft.aufirst=Michele&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Understanding Breast Changes: An Inupiaq-English Radio Show to Encourage Breast Cancer Screening T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41849408; 5065499 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Lavigne, Marie AU - Briant, Katherine AU - Slatton, Jozieta Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Breast cancer KW - Screening KW - Radio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Understanding+Breast+Changes%3A+An+Inupiaq-English+Radio+Show+to+Encourage+Breast+Cancer+Screening&rft.au=Lavigne%2C+Marie%3BBriant%2C+Katherine%3BSlatton%2C+Jozieta&rft.aulast=Lavigne&rft.aufirst=Marie&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do research participants share the results of genetic susceptibility testing for Alzheimer's disease with family, friends, and health professionals? Insights from the REVEAL Study T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41849240; 5067890 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Ashida, Sato AU - Koehly, Laura AU - Roberts, J AU - Chen, Clara AU - Hiraki, Susan AU - Green, Robert Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Alzheimer's disease KW - Neurodegenerative diseases KW - Experts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Do+research+participants+share+the+results+of+genetic+susceptibility+testing+for+Alzheimer%27s+disease+with+family%2C+friends%2C+and+health+professionals%3F+Insights+from+the+REVEAL+Study&rft.au=Ashida%2C+Sato%3BKoehly%2C+Laura%3BRoberts%2C+J%3BChen%2C+Clara%3BHiraki%2C+Susan%3BGreen%2C+Robert&rft.aulast=Ashida&rft.aufirst=Sato&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Facilitating the translation of research tested interventions into practice: The role of the NCI's Cancer Information Service T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41848721; 5068922 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Fleisher, Linda AU - Krebill, Hope AU - Briant, Katherine AU - McFarlane, Anita AU - Candreia, Myrna AU - LaPorta, Madeline Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Cancer KW - Intervention KW - Translation KW - Information systems KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Facilitating+the+translation+of+research+tested+interventions+into+practice%3A+The+role+of+the+NCI%27s+Cancer+Information+Service&rft.au=Fleisher%2C+Linda%3BKrebill%2C+Hope%3BBriant%2C+Katherine%3BMcFarlane%2C+Anita%3BCandreia%2C+Myrna%3BLaPorta%2C+Madeline&rft.aulast=Fleisher&rft.aufirst=Linda&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building capacity for cessation services in primary care settings; A health systems approach T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41848201; 5068791 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Rarick, James AU - Lee, Hye-ryeon AU - Ng-Osorio, Jackie Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Building+capacity+for+cessation+services+in+primary+care+settings%3B+A+health+systems+approach&rft.au=Rarick%2C+James%3BLee%2C+Hye-ryeon%3BNg-Osorio%2C+Jackie&rft.aulast=Rarick&rft.aufirst=James&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changing the landscape of funding: Collaborations that leverage resources to reach populations most in need T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41847820; 5068920 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Gonzalez, Evelyn AU - Vinson, Cynthia AU - La Porta, Madeline AU - Oliveros, Catherine AU - Thompson, Ginny Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Landscape KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Changing+the+landscape+of+funding%3A+Collaborations+that+leverage+resources+to+reach+populations+most+in+need&rft.au=Gonzalez%2C+Evelyn%3BVinson%2C+Cynthia%3BLa+Porta%2C+Madeline%3BOliveros%2C+Catherine%3BThompson%2C+Ginny&rft.aulast=Gonzalez&rft.aufirst=Evelyn&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring decision making: Why do Hispanics and African Americans participate in HIV/AIDS clinical research? T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41844303; 5067846 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Rivera-Goba, Migdalia AU - Dominguez, Dinora AU - Grady, Christine AU - Stoll, Pamela AU - Ramos, Catalina AU - Morgan, Marcela AU - Miranda-Acevedo, Robert AU - Aizvera, Jeasmine AU - Koziol, Deloris AU - Purdie, Lori AU - Mican, JoAnn Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Africa KW - Ethnic groups KW - Clinical trials KW - Human immunodeficiency virus KW - Acquired immune deficiency syndrome KW - Decision making KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Exploring+decision+making%3A+Why+do+Hispanics+and+African+Americans+participate+in+HIV%2FAIDS+clinical+research%3F&rft.au=Rivera-Goba%2C+Migdalia%3BDominguez%2C+Dinora%3BGrady%2C+Christine%3BStoll%2C+Pamela%3BRamos%2C+Catalina%3BMorgan%2C+Marcela%3BMiranda-Acevedo%2C+Robert%3BAizvera%2C+Jeasmine%3BKoziol%2C+Deloris%3BPurdie%2C+Lori%3BMican%2C+JoAnn&rft.aulast=Rivera-Goba&rft.aufirst=Migdalia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of "Crossroads" a tobacco prevention drama for Middle School students in Hawaii T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41843936; 5070097 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Cassel, Kevin AU - Loebl, Karen AU - Tatafu, Elitei AU - Segal-Matsunaga, Doris AU - Mitschke, Diane Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA, Hawaii KW - Prevention KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Evaluation+of+%22Crossroads%22+a+tobacco+prevention+drama+for+Middle+School+students+in+Hawaii&rft.au=Cassel%2C+Kevin%3BLoebl%2C+Karen%3BTatafu%2C+Elitei%3BSegal-Matsunaga%2C+Doris%3BMitschke%2C+Diane&rft.aulast=Cassel&rft.aufirst=Kevin&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Overweight and Obesity with Health-Risk Behaviors among US Youth T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41842768; 5069300 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Farhat, Tilda AU - Iannotti, Ronald Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Obesity KW - Body weight KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Association+of+Overweight+and+Obesity+with+Health-Risk+Behaviors+among+US+Youth&rft.au=Farhat%2C+Tilda%3BIannotti%2C+Ronald&rft.aulast=Farhat&rft.aufirst=Tilda&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disseminating the cancer screening process through development, implementation, and evaluation of an e-learning program T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41840923; 5070548 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Swarz, Jeffrey AU - Burns, David Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Cancer KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41840923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Disseminating+the+cancer+screening+process+through+development%2C+implementation%2C+and+evaluation+of+an+e-learning+program&rft.au=Swarz%2C+Jeffrey%3BBurns%2C+David&rft.aulast=Swarz&rft.aufirst=Jeffrey&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Restricting access to vending machines in schools: A strategy to improve the school-nutrition environment? T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41839665; 5069549 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Thompson, Olivia AU - Agurs-Collins, Tanya AU - Yaroch, Amy AU - Moser, Richard Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Schools KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Restricting+access+to+vending+machines+in+schools%3A+A+strategy+to+improve+the+school-nutrition+environment%3F&rft.au=Thompson%2C+Olivia%3BAgurs-Collins%2C+Tanya%3BYaroch%2C+Amy%3BMoser%2C+Richard&rft.aulast=Thompson&rft.aufirst=Olivia&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Evidence-Based Programming on Comprehensive Cancer Control T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41837088; 5068921 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Briant, Katherine AU - Jacobson, Janelle AU - Brown, Maebe AU - Covington, Carol AU - Nass, Carrie Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Cancer KW - Planning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41837088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Impact+of+Evidence-Based+Programming+on+Comprehensive+Cancer+Control&rft.au=Briant%2C+Katherine%3BJacobson%2C+Janelle%3BBrown%2C+Maebe%3BCovington%2C+Carol%3BNass%2C+Carrie&rft.aulast=Briant&rft.aufirst=Katherine&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using CHIS data to Measure and Understand Racial and Ethnic Disparities T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41837043; 5067570 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Shariff-Marco, Salma AU - Breen, Nancy AU - Browner, Deirdre AU - Brown, E Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41837043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Using+CHIS+data+to+Measure+and+Understand+Racial+and+Ethnic+Disparities&rft.au=Shariff-Marco%2C+Salma%3BBreen%2C+Nancy%3BBrowner%2C+Deirdre%3BBrown%2C+E&rft.aulast=Shariff-Marco&rft.aufirst=Salma&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Testing innovative approaches for communicating with lay individuals about genetic concepts using virtual reality technology T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41835537; 5068489 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Kaphingst, Kimberly AU - Persky, Susan AU - Lachance, Christina AU - McCall, Cade AU - Loewenstein, Johanna AU - Beall, Andrew AU - Blascovich, James Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Technology KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41835537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Testing+innovative+approaches+for+communicating+with+lay+individuals+about+genetic+concepts+using+virtual+reality+technology&rft.au=Kaphingst%2C+Kimberly%3BPersky%2C+Susan%3BLachance%2C+Christina%3BMcCall%2C+Cade%3BLoewenstein%2C+Johanna%3BBeall%2C+Andrew%3BBlascovich%2C+James&rft.aulast=Kaphingst&rft.aufirst=Kimberly&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NHLBI's SNP Health Association Resource (SHARe) Project: A New Model for Access to Genetic Epidemiology Data T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41834970; 5066468 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Pandey, Mona AU - Jaquish, Cashell AU - Papanicolaou, George AU - O'Donnell, Christopher AU - Fabsitz, Richard Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Data processing KW - Single-nucleotide polymorphism KW - Models KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=NHLBI%27s+SNP+Health+Association+Resource+%28SHARe%29+Project%3A+A+New+Model+for+Access+to+Genetic+Epidemiology+Data&rft.au=Pandey%2C+Mona%3BJaquish%2C+Cashell%3BPapanicolaou%2C+George%3BO%27Donnell%2C+Christopher%3BFabsitz%2C+Richard&rft.aulast=Pandey&rft.aufirst=Mona&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measuring self-reported racial/ethnic discrimination in multicultural health surveys T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41832105; 5067573 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Shariff-Marco, Salma Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Discrimination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41832105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Measuring+self-reported+racial%2Fethnic+discrimination+in+multicultural+health+surveys&rft.au=Shariff-Marco%2C+Salma&rft.aulast=Shariff-Marco&rft.aufirst=Salma&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trade and transportation: Impact on environmental public health T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41829569; 5065248 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Dearry, Allen Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Public health KW - Transportation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Trade+and+transportation%3A+Impact+on+environmental+public+health&rft.au=Dearry%2C+Allen&rft.aulast=Dearry&rft.aufirst=Allen&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aging and Cancer: A Cancer 101 Adaptation to Meet the Needs of Elders T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41827099; 5067020 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Lavigne, Marie AU - Briant, Katherine Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Cancer KW - Aging KW - Elderly KW - Adaptability KW - Adaptations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41827099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Aging+and+Cancer%3A+A+Cancer+101+Adaptation+to+Meet+the+Needs+of+Elders&rft.au=Lavigne%2C+Marie%3BBriant%2C+Katherine&rft.aulast=Lavigne&rft.aufirst=Marie&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence and correlates of sexual concurrency among urban crack-using men T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41826592; 5067654 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Freeman, Robert Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41826592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Prevalence+and+correlates+of+sexual+concurrency+among+urban+crack-using+men&rft.au=Freeman%2C+Robert&rft.aulast=Freeman&rft.aufirst=Robert&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using audience research to ensure that health education materials are understandable and appropriate: Developing and pretesting "Are you at risk for oral cancer? What African American men need to know" T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41816493; 5070307 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Boehm, Karina AU - Beltran, Marco AU - Daum, Mary Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Africa KW - Cancer KW - Ethnic groups KW - Education KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41816493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Using+audience+research+to+ensure+that+health+education+materials+are+understandable+and+appropriate%3A+Developing+and+pretesting+%22Are+you+at+risk+for+oral+cancer%3F+What+African+American+men+need+to+know%22&rft.au=Boehm%2C+Karina%3BBeltran%2C+Marco%3BDaum%2C+Mary&rft.aulast=Boehm&rft.aufirst=Karina&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hearing loss, frequent ear infections, speech-language development and therapy, and use of other services in preschool-aged children in the United States T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41808992; 5069047 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Hoffman, Howard AU - Park, Jennifer AU - Losonczy, Katalin AU - Chiu, May Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - USA KW - Infection KW - Hearing loss KW - Children KW - Speech KW - Language KW - Ear KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41808992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Hearing+loss%2C+frequent+ear+infections%2C+speech-language+development+and+therapy%2C+and+use+of+other+services+in+preschool-aged+children+in+the+United+States&rft.au=Hoffman%2C+Howard%3BPark%2C+Jennifer%3BLosonczy%2C+Katalin%3BChiu%2C+May&rft.aulast=Hoffman&rft.aufirst=Howard&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characteristics of current and recent former smokers associated with the use of new potential reduced-exposure tobacco products (PREPs) T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41808336; 5068766 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Parascandola, Mark AU - Augustson, Erik AU - Rose, Allison Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41808336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Characteristics+of+current+and+recent+former+smokers+associated+with+the+use+of+new+potential+reduced-exposure+tobacco+products+%28PREPs%29&rft.au=Parascandola%2C+Mark%3BAugustson%2C+Erik%3BRose%2C+Allison&rft.aulast=Parascandola&rft.aufirst=Mark&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intimate partner violence and depression in a population of pregnant African American residents of the District of Columbia: A risky combination T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41805722; 5066373 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Kiely, Michele AU - El-Khorazaty, M AU - Gantz, Marie AU - El-Mohandes, Ayman Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Africa KW - Pregnancy KW - Domestic violence KW - Ethnic groups KW - Depression KW - Aggression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41805722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Intimate+partner+violence+and+depression+in+a+population+of+pregnant+African+American+residents+of+the+District+of+Columbia%3A+A+risky+combination&rft.au=Kiely%2C+Michele%3BEl-Khorazaty%2C+M%3BGantz%2C+Marie%3BEl-Mohandes%2C+Ayman&rft.aulast=Kiely&rft.aufirst=Michele&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in Stage-Specific Survival for Colorectal Cancer in Asian Subgroups by Census Tract Education T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41804455; 5069213 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Ham, Leyda Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Census KW - Colorectal carcinoma KW - Survival KW - Education KW - Colorectal cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41804455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Differences+in+Stage-Specific+Survival+for+Colorectal+Cancer+in+Asian+Subgroups+by+Census+Tract+Education&rft.au=Ham%2C+Leyda&rft.aulast=Ham&rft.aufirst=Leyda&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complementary and Alternative Medicine usage in Minority Patients with Rheumatic Diseases T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41801048; 5070731 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Middleton, Kimberly AU - Wallen, Gwenyth Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Rheumatic diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41801048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Complementary+and+Alternative+Medicine+usage+in+Minority+Patients+with+Rheumatic+Diseases&rft.au=Middleton%2C+Kimberly%3BWallen%2C+Gwenyth&rft.aulast=Middleton&rft.aufirst=Kimberly&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Outcomes of training rural, Appalachia community-based cancer coalitions,agency and clinical partners in adapting and using evidence-based programs T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41800480; 5068923 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Gonzalez, Evelyn AU - Kluhsman, Brenda AU - McFarlane, Anita AU - Jaitley, Vijai AU - Widman, Christy AU - Bencivenga, Marcyann AU - Homick, Heather AU - Lengerich, Eugene AU - Fleisher, Linda Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Cancer KW - Rural areas KW - Training KW - Adaptability KW - Community involvement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41800480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Outcomes+of+training+rural%2C+Appalachia+community-based+cancer+coalitions%2Cagency+and+clinical+partners+in+adapting+and+using+evidence-based+programs&rft.au=Gonzalez%2C+Evelyn%3BKluhsman%2C+Brenda%3BMcFarlane%2C+Anita%3BJaitley%2C+Vijai%3BWidman%2C+Christy%3BBencivenga%2C+Marcyann%3BHomick%2C+Heather%3BLengerich%2C+Eugene%3BFleisher%2C+Linda&rft.aulast=Gonzalez&rft.aufirst=Evelyn&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Cancer Institute's State Cancer Legislative Database (SCLD): A resource for tobacco control researchers T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41799865; 5068773 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - El Arculli, Regina AU - Gallotta, Elizabeth AU - Freudenwald, Jill AU - Fues, Liza Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Cancer KW - Tobacco KW - Legislation KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41799865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=National+Cancer+Institute%27s+State+Cancer+Legislative+Database+%28SCLD%29%3A+A+resource+for+tobacco+control+researchers&rft.au=El+Arculli%2C+Regina%3BGallotta%2C+Elizabeth%3BFreudenwald%2C+Jill%3BFues%2C+Liza&rft.aulast=El+Arculli&rft.aufirst=Regina&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Psychiatric outcomes in women with adverse childhood experiences: A national level study in US T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41797015; 5066457 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Saha, Tulshi AU - Grant, Bridget Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41797015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Psychiatric+outcomes+in+women+with+adverse+childhood+experiences%3A+A+national+level+study+in+US&rft.au=Saha%2C+Tulshi%3BGrant%2C+Bridget&rft.aulast=Saha&rft.aufirst=Tulshi&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethnic differences in body weight and body appearance perception among US schoolchildren: Results from the 2001 HBSC survey T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41795646; 5067716 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Farhat, Tilda AU - Mikolajczyk, Rafael AU - Iannotti, Ronald AU - Thomas, Vijaya Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Body weight KW - Children KW - Perception KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41795646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=Ethnic+differences+in+body+weight+and+body+appearance+perception+among+US+schoolchildren%3A+Results+from+the+2001+HBSC+survey&rft.au=Farhat%2C+Tilda%3BMikolajczyk%2C+Rafael%3BIannotti%2C+Ronald%3BThomas%2C+Vijaya&rft.aulast=Farhat&rft.aufirst=Tilda&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - No Drop in Mammograms Here: What makes the Golden State Exceptional? T2 - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AN - 41789400; 5067571 JF - 136th American Public Health Association Annual Meeting and Exposition (APHA 2008) AU - Breen, Nancy Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41789400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.atitle=No+Drop+in+Mammograms+Here%3A+What+makes+the+Golden+State+Exceptional%3F&rft.au=Breen%2C+Nancy&rft.aulast=Breen&rft.aufirst=Nancy&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=136th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/136am/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From the Mouths of Babes: Primary Immunodeficiencies as Guides to Immunotherapy T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40348834; 5261222 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Holland, Steve Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Immunotherapy KW - Immunodeficiency KW - Mouth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=From+the+Mouths+of+Babes%3A+Primary+Immunodeficiencies+as+Guides+to+Immunotherapy&rft.au=Holland%2C+Steve&rft.aulast=Holland&rft.aufirst=Steve&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathogenesis of CA-MRSA Infections T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40345921; 5261277 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Deleo, Frank Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Infection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Pathogenesis+of+CA-MRSA+Infections&rft.au=Deleo%2C+Frank&rft.aulast=Deleo&rft.aufirst=Frank&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune evasion and biofilm dissemination, key molecular mechanisms defining the pathogenic potential of Staphylococcus epidermidis T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40342316; 5261210 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Otto, Michael Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Biofilms KW - Molecular modelling KW - Staphylococcus epidermidis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Immune+evasion+and+biofilm+dissemination%2C+key+molecular+mechanisms+defining+the+pathogenic+potential+of+Staphylococcus+epidermidis&rft.au=Otto%2C+Michael&rft.aulast=Otto&rft.aufirst=Michael&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Update on Mother to Child HIV Transmission T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40342311; 5261214 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Mofenson, Lynne Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Disease transmission KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Update+on+Mother+to+Child+HIV+Transmission&rft.au=Mofenson%2C+Lynne&rft.aulast=Mofenson&rft.aufirst=Lynne&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Norovirus: Surveillance, Diagnosis, and Genetics T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40342189; 5261282 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Green, Kim Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Genetics KW - Norovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Norovirus%3A+Surveillance%2C+Diagnosis%2C+and+Genetics&rft.au=Green%2C+Kim&rft.aulast=Green&rft.aufirst=Kim&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Reservoirs of HIV T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40342118; 5261260 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Chun, Tae-Wook Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Human immunodeficiency virus KW - Reservoirs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Cellular+Reservoirs+of+HIV&rft.au=Chun%2C+Tae-Wook&rft.aulast=Chun&rft.aufirst=Tae-Wook&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Containing the Ebola Virus T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40342063; 5261248 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Nabel, Gary Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Ebola virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Containing+the+Ebola+Virus&rft.au=Nabel%2C+Gary&rft.aulast=Nabel&rft.aufirst=Gary&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Malaria Vaccines T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40328007; 5260929 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Fenton Hall, B Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Vaccines KW - Malaria KW - Reviews KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Overview+of+Malaria+Vaccines&rft.au=Fenton+Hall%2C+B&rft.aulast=Fenton+Hall&rft.aufirst=B&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validation of the MOS-HIV as a Measure of Health-Related Quality of Life in Persons Living with HIV and Liver Disease T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40327480; 5258435 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Henderson, W AU - Schlenk, E AU - Kim, K AU - Hadigan, C AU - Sereika, S AU - Erlen, J Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Quality of life KW - Human immunodeficiency virus KW - Liver diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40327480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Validation+of+the+MOS-HIV+as+a+Measure+of+Health-Related+Quality+of+Life+in+Persons+Living+with+HIV+and+Liver+Disease&rft.au=Henderson%2C+W%3BSchlenk%2C+E%3BKim%2C+K%3BHadigan%2C+C%3BSereika%2C+S%3BErlen%2C+J&rft.aulast=Henderson&rft.aufirst=W&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma Kinetics of Circulating Galactomannan Antigen After Infusion of Plasma-Lyte T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40326039; 5258718 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Petraitiene, R AU - Petraitis, V AU - Witt, J AU - Durkin, M AU - Wheat, L AU - Walsh, T Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Kinetics KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40326039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Plasma+Kinetics+of+Circulating+Galactomannan+Antigen+After+Infusion+of+Plasma-Lyte&rft.au=Petraitiene%2C+R%3BPetraitis%2C+V%3BWitt%2C+J%3BDurkin%2C+M%3BWheat%2C+L%3BWalsh%2C+T&rft.aulast=Petraitiene&rft.aufirst=R&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Safety, Tolerability and Pharmacokinetics of Liposomal Amphotericin B in Immunocompromised Pediatric Patients T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40325665; 5258604 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Walsh, T AU - Shad, A AU - Bekersky, I AU - Gonzalez, C AU - Groll, A AU - Wood, L AU - Buell, D AU - Seibel, N Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Pharmacokinetics KW - Pediatrics KW - Amphotericin B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40325665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Safety%2C+Tolerability+and+Pharmacokinetics+of+Liposomal+Amphotericin+B+in+Immunocompromised+Pediatric+Patients&rft.au=Walsh%2C+T%3BShad%2C+A%3BBekersky%2C+I%3BGonzalez%2C+C%3BGroll%2C+A%3BWood%2C+L%3BBuell%2C+D%3BSeibel%2C+N&rft.aulast=Walsh&rft.aufirst=T&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunopathology of Crohn's Disease and the Role of Commensal Bacteria T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40325560; 5261073 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Strober, Warren Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Commensals KW - Crohn's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40325560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Immunopathology+of+Crohn%27s+Disease+and+the+Role+of+Commensal+Bacteria&rft.au=Strober%2C+Warren&rft.aulast=Strober&rft.aufirst=Warren&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Factors Influencing the Permeability of Amphotericin B (AmB) in an In Vitro blood brain barrier (BBB) Model T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40325443; 5258603 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Pyrgos, V AU - Mickiene, D AU - Fransesconi, A AU - Cotton, M AU - Donoghue, M AU - Hardwick, M AU - Benjamin, D AU - Shoham, S AU - Walsh, T Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Permeability KW - Brain KW - Blood-brain barrier KW - Models KW - Amphotericin B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40325443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Factors+Influencing+the+Permeability+of+Amphotericin+B+%28AmB%29+in+an+In+Vitro+blood+brain+barrier+%28BBB%29+Model&rft.au=Pyrgos%2C+V%3BMickiene%2C+D%3BFransesconi%2C+A%3BCotton%2C+M%3BDonoghue%2C+M%3BHardwick%2C+M%3BBenjamin%2C+D%3BShoham%2C+S%3BWalsh%2C+T&rft.aulast=Pyrgos&rft.aufirst=V&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coronary Plaque Volume by CT Angiography Correlates with Duration of Antiretroviral Therapy T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40324686; 5260074 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Hadigan, C AU - Healey, L AU - Muldoon, N AU - Sanko, J AU - Georgoff, P AU - Gharib, A Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Antiretroviral agents KW - Angiography KW - Plaques KW - Antiretroviral therapy KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40324686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Coronary+Plaque+Volume+by+CT+Angiography+Correlates+with+Duration+of+Antiretroviral+Therapy&rft.au=Hadigan%2C+C%3BHealey%2C+L%3BMuldoon%2C+N%3BSanko%2C+J%3BGeorgoff%2C+P%3BGharib%2C+A&rft.aulast=Hadigan&rft.aufirst=C&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mitochondrial Translocator Protein (TSPO) Ligand Inhibits Amphotericin B-induced Apoptosis in Renal Renal Tubular Epithelial Cells T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40323740; 5258602 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Demchok, J AU - Seufert, C AU - Hardwick, M AU - Shoham, S AU - Walsh, T Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Kidneys KW - Mitochondria KW - Epithelial cells KW - Apoptosis KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40323740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Mitochondrial+Translocator+Protein+%28TSPO%29+Ligand+Inhibits+Amphotericin+B-induced+Apoptosis+in+Renal+Renal+Tubular+Epithelial+Cells&rft.au=Demchok%2C+J%3BSeufert%2C+C%3BHardwick%2C+M%3BShoham%2C+S%3BWalsh%2C+T&rft.aulast=Demchok&rft.aufirst=J&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Twice Weekly Peg IFN-alpha-2a with Ribavirin Improves Early Viral Kinetics over Standard Therapy Among HIV/HCV Co-infected African American Patients T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40322844; 5261067 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Murphy, A AU - Rozenberg, L AU - Polis, M AU - Frank, A AU - Masur, H AU - Neumann, A AU - Kottilil, S Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Africa KW - Human immunodeficiency virus KW - Kinetics KW - Ethnic groups KW - Ribavirin KW - Therapy KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40322844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Twice+Weekly+Peg+IFN-alpha-2a+with+Ribavirin+Improves+Early+Viral+Kinetics+over+Standard+Therapy+Among+HIV%2FHCV+Co-infected+African+American+Patients&rft.au=Murphy%2C+A%3BRozenberg%2C+L%3BPolis%2C+M%3BFrank%2C+A%3BMasur%2C+H%3BNeumann%2C+A%3BKottilil%2C+S&rft.aulast=Murphy&rft.aufirst=A&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Immune Reconstitution by Macrophages on the Kinetics of Four Aspergillus Species in an In Vitro Lung Model of Early Invasive Pulmonary Aspergillosis T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40321182; 5259540 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Donoghue, M AU - Francesconi, A AU - Petraitiene, R AU - Hope, W AU - Demchok, J AU - Seufert, C AU - Pyrgos, V AU - Sein, T AU - Kasai, M AU - Seibel, N AU - Schaufele, R AU - Walsh, T Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Lung KW - Kinetics KW - Aspergillosis KW - Macrophages KW - Immune reconstitution KW - Models KW - Aspergillus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40321182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=The+Effects+of+Immune+Reconstitution+by+Macrophages+on+the+Kinetics+of+Four+Aspergillus+Species+in+an+In+Vitro+Lung+Model+of+Early+Invasive+Pulmonary+Aspergillosis&rft.au=Donoghue%2C+M%3BFrancesconi%2C+A%3BPetraitiene%2C+R%3BHope%2C+W%3BDemchok%2C+J%3BSeufert%2C+C%3BPyrgos%2C+V%3BSein%2C+T%3BKasai%2C+M%3BSeibel%2C+N%3BSchaufele%2C+R%3BWalsh%2C+T&rft.aulast=Donoghue&rft.aufirst=M&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Kinetics of Galactomannan (GM) and (1,3)B-D-Glucan (BG) in Early Experimental Invasive Pulmonary Aspergillosis (IPA): Correlation with Histopathology T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40320439; 5259501 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Hope, W AU - Petraitiene, R AU - Petraitis, V AU - Sein, T AU - Walsh, T Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Histopathology KW - Kinetics KW - Aspergillosis KW - Lung KW - Aspergillus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40320439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Comparative+Kinetics+of+Galactomannan+%28GM%29+and+%281%2C3%29B-D-Glucan+%28BG%29+in+Early+Experimental+Invasive+Pulmonary+Aspergillosis+%28IPA%29%3A+Correlation+with+Histopathology&rft.au=Hope%2C+W%3BPetraitiene%2C+R%3BPetraitis%2C+V%3BSein%2C+T%3BWalsh%2C+T&rft.aulast=Hope&rft.aufirst=W&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prospective Study of Oral, Tympanic, and Temporal Artery Thermometry in Pediatric Patients T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40320188; 5259273 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Walsh, T AU - Woolery, M AU - Knudsen, T AU - Milanovich, J AU - Steinberg, S AU - Liewehr, D AU - Turk, S Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Pediatrics KW - Arteries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40320188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Prospective+Study+of+Oral%2C+Tympanic%2C+and+Temporal+Artery+Thermometry+in+Pediatric+Patients&rft.au=Walsh%2C+T%3BWoolery%2C+M%3BKnudsen%2C+T%3BMilanovich%2C+J%3BSteinberg%2C+S%3BLiewehr%2C+D%3BTurk%2C+S&rft.aulast=Walsh&rft.aufirst=T&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determining the Genetic Basis of Amodiaquine Resistance Using its Active Metabolite T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40319784; 5259553 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Sa, J. AU - Twu, O AU - Hayton, K AU - Ringwald, P AU - Wellems, T Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Metabolites KW - Amodiaquine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40319784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Determining+the+Genetic+Basis+of+Amodiaquine+Resistance+Using+its+Active+Metabolite&rft.au=Sa%2C+J.%3BTwu%2C+O%3BHayton%2C+K%3BRingwald%2C+P%3BWellems%2C+T&rft.aulast=Sa&rft.aufirst=J.&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Health and Infectious Diseases: A Look to the Future T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40319154; 5258102 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Fauci, Anthony Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Infectious diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40319154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Global+Health+and+Infectious+Diseases%3A+A+Look+to+the+Future&rft.au=Fauci%2C+Anthony&rft.aulast=Fauci&rft.aufirst=Anthony&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Host-Dependent Effects on Expression of Galactomannan (GM) and (1,3)-b-D-Glucan (BG) in Experimental Invasive Pulmonary Aspergillosis (IPA) T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40316579; 5260999 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Petraitiene, R AU - Petraitis, V AU - Cotton, M AU - Greene, L AU - Sein, T AU - Bacher, J AU - Walsh, T Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Aspergillosis KW - Lung KW - Aspergillus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40316579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Host-Dependent+Effects+on+Expression+of+Galactomannan+%28GM%29+and+%281%2C3%29-b-D-Glucan+%28BG%29+in+Experimental+Invasive+Pulmonary+Aspergillosis+%28IPA%29&rft.au=Petraitiene%2C+R%3BPetraitis%2C+V%3BCotton%2C+M%3BGreene%2C+L%3BSein%2C+T%3BBacher%2C+J%3BWalsh%2C+T&rft.aulast=Petraitiene&rft.aufirst=R&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bliss Independence Interaction Analysis of the Inhibitory Effects of Hydrocortisone and Glucose on Human Neutrophil Mediated Hyphal Damage to Rhizopus oryzae T2 - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AN - 40315824; 5259538 JF - Joint 48th Interscience Conference on Antimicrobial Agents and Chemotherapy and 46th Annual Meeting of the Infectious Diseases Society of America AU - Demchok, J AU - Meletiadis, J AU - Stergiopoulou, T AU - Antachopoulos, C AU - Kontoyiannis, D AU - Roilides, E AU - Walsh, T Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 KW - Hydrocortisone KW - Glucose KW - Leukocytes (neutrophilic) KW - Rhizopus oryzae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40315824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Bliss+Independence+Interaction+Analysis+of+the+Inhibitory+Effects+of+Hydrocortisone+and+Glucose+on+Human+Neutrophil+Mediated+Hyphal+Damage+to+Rhizopus+oryzae&rft.au=Demchok%2C+J%3BMeletiadis%2C+J%3BStergiopoulou%2C+T%3BAntachopoulos%2C+C%3BKontoyiannis%2C+D%3BRoilides%2C+E%3BWalsh%2C+T&rft.aulast=Demchok&rft.aufirst=J&rft.date=2008-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+48th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+and+46th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={26DFAE32 -3D6D-446F-9AE5-B759FE42C683}&AKey={B156596F-4F2B-4B7B-9988-53EF0A52 3ACC} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-28 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Inhibition of norovirus replication by morpholino oligomers targeting the 5'-end of the genome AN - 19710127; 8578659 AB - Noroviruses are an important cause of non-bacterial epidemic gastroenteritis, but no specific antiviral therapies are available. We investigated the inhibitory effect of phosphorodiamidiate morpholino oligomers (PMOs) targeted against norovirus sequences. A panel of peptide-conjugated PMOs (PPMOs) specific for the murine norovirus (MNV) genome was developed, and two PPMO compounds directed against the first AUG of the ORF1 coding sequence near the 5'-end of the genome proved effective in inhibiting MNV replication in cells. A consensus PPMO (designated Noro 1.1), designed to target the corresponding region of several diverse human norovirus genotypes, decreased the efficiency of protein translation in a cell-free luciferase reporter assay and inhibited Norwalk virus protein expression in replicon-bearing cells. Our data suggest that PPMOs directed against the relatively conserved 5'-end of the norovirus genome may show broad antiviral activity against this genetically diverse group of viruses. JF - Virology AU - Bok, K AU - Cavanaugh, V J AU - Matson, DO AU - Gonzalez-Molleda, L AU - Chang, KO AU - Zintz, C AU - Smith, A W AU - Iversen, P AU - Green, KY AU - Campbell, A E AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, 50 South Drive, Bldg. 50, Room 6316, Bethesda, MD 20892, USA, bokk@niaid.nih.gov Y1 - 2008/10/25/ PY - 2008 DA - 2008 Oct 25 SP - 328 EP - 337 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 380 IS - 2 SN - 0042-6822, 0042-6822 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Virology & AIDS Abstracts KW - Genomes KW - Translation KW - Data processing KW - Epidemics KW - Replication KW - Norwalk virus KW - Nucleotide sequence KW - Norovirus KW - Genotypes KW - Antiviral activity KW - Gastroenteritis KW - J 02320:Cell Biology KW - V 22320:Replication KW - N 14830:RNA KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Inhibition+of+norovirus+replication+by+morpholino+oligomers+targeting+the+5%27-end+of+the+genome&rft.au=Bok%2C+K%3BCavanaugh%2C+V+J%3BMatson%2C+DO%3BGonzalez-Molleda%2C+L%3BChang%2C+KO%3BZintz%2C+C%3BSmith%2C+A+W%3BIversen%2C+P%3BGreen%2C+KY%3BCampbell%2C+A+E&rft.aulast=Bok&rft.aufirst=K&rft.date=2008-10-25&rft.volume=380&rft.issue=2&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2008.08.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Translation; Epidemics; Data processing; Replication; Nucleotide sequence; Genotypes; Gastroenteritis; Antiviral activity; Norwalk virus; Norovirus DO - http://dx.doi.org/10.1016/j.virol.2008.08.007 ER - TY - CPAPER T1 - Autoantibodies Against Aquaporins in primary Sjogren's Syndrome (pSS) T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41974236; 5121723 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Nikolov, Nikolay AU - Burbelo, Peter AU - Leahy, Hannah AU - Groot, Sandra AU - Alba, Maria AU - Baraniuk, James AU - Iadarola, Michael AU - Illei, Gabor Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Autoantibodies KW - Aquaporins KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41974236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Autoantibodies+Against+Aquaporins+in+primary+Sjogren%27s+Syndrome+%28pSS%29&rft.au=Nikolov%2C+Nikolay%3BBurbelo%2C+Peter%3BLeahy%2C+Hannah%3BGroot%2C+Sandra%3BAlba%2C+Maria%3BBaraniuk%2C+James%3BIadarola%2C+Michael%3BIllei%2C+Gabor&rft.aulast=Nikolov&rft.aufirst=Nikolay&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical and Functional Significance of P369S and R408Q Variants in the Familial Mediterranean Fever-associated Gene MEFV T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41966765; 5121073 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Ryan, John AU - Booty, Matthew AU - Barham, Beverly AU - Remmers, Elaine AU - Kastner, Daniel AU - Aksentijevich, Ivona AU - Masters, Seth AU - Barron, Karyl Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - MED KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41966765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Clinical+and+Functional+Significance+of+P369S+and+R408Q+Variants+in+the+Familial+Mediterranean+Fever-associated+Gene+MEFV&rft.au=Ryan%2C+John%3BBooty%2C+Matthew%3BBarham%2C+Beverly%3BRemmers%2C+Elaine%3BKastner%2C+Daniel%3BAksentijevich%2C+Ivona%3BMasters%2C+Seth%3BBarron%2C+Karyl&rft.aulast=Ryan&rft.aufirst=John&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Treatment on Disease Damage in Juvenile and Adult Myositis T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41955431; 5119698 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Rider, L AU - Lachenbruch, P AU - James-Newton, L AU - Cabalar, I AU - Feldman, B AU - Ravelli, A AU - Myones, B AU - Rennebohm, R AU - Pachman, L AU - Villalba, M AU - Adams, E AU - Lindsley, C AU - Wallace, C AU - Ballinger, S AU - Zemel, L AU - Reed, A AU - Miller, F Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Myositis KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41955431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Effects+of+Treatment+on+Disease+Damage+in+Juvenile+and+Adult+Myositis&rft.au=Rider%2C+L%3BLachenbruch%2C+P%3BJames-Newton%2C+L%3BCabalar%2C+I%3BFeldman%2C+B%3BRavelli%2C+A%3BMyones%2C+B%3BRennebohm%2C+R%3BPachman%2C+L%3BVillalba%2C+M%3BAdams%2C+E%3BLindsley%2C+C%3BWallace%2C+C%3BBallinger%2C+S%3BZemel%2C+L%3BReed%2C+A%3BMiller%2C+F&rft.aulast=Rider&rft.aufirst=L&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predictors of Calcinosis in Juvenile and Adult Dermatomyositis (DM) T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41941945; 5119699 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Rider, L AU - Lachenbruch, P AU - James-Newton, L AU - Cabalar, I AU - Feldman, B AU - Ravelli, A AU - Myones, B AU - Rennebohm, R AU - Pachman, L AU - Villalba, M AU - Adams, E AU - Lindsley, C AU - Wallace, C AU - Ballinger, S AU - Zemel, L AU - Reed, A AU - Miller, F Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Calcinosis KW - Dermatomyositis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41941945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Predictors+of+Calcinosis+in+Juvenile+and+Adult+Dermatomyositis+%28DM%29&rft.au=Rider%2C+L%3BLachenbruch%2C+P%3BJames-Newton%2C+L%3BCabalar%2C+I%3BFeldman%2C+B%3BRavelli%2C+A%3BMyones%2C+B%3BRennebohm%2C+R%3BPachman%2C+L%3BVillalba%2C+M%3BAdams%2C+E%3BLindsley%2C+C%3BWallace%2C+C%3BBallinger%2C+S%3BZemel%2C+L%3BReed%2C+A%3BMiller%2C+F&rft.aulast=Rider&rft.aufirst=L&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lymphoid Tissue Inducer-like Cells Are an Innate Source of IL-17 and IL-22 T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41933085; 5119588 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Takatori, Hiroaki AU - Kanno, Yuka AU - O'Shea, John AU - Tato, Cristina AU - Weiss, Greta Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Interleukin 22 KW - Interleukin 17 KW - Lymphoid tissue KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41933085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Lymphoid+Tissue+Inducer-like+Cells+Are+an+Innate+Source+of+IL-17+and+IL-22&rft.au=Takatori%2C+Hiroaki%3BKanno%2C+Yuka%3BO%27Shea%2C+John%3BTato%2C+Cristina%3BWeiss%2C+Greta&rft.aulast=Takatori&rft.aufirst=Hiroaki&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differences in Self-Reported Physical Function Among the Elderly: NHANES III T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41926506; 5119634 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Louie, Grant AU - Ward, Michael Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Sex KW - Elderly KW - Sex differences KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41926506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Gender+Differences+in+Self-Reported+Physical+Function+Among+the+Elderly%3A+NHANES+III&rft.au=Louie%2C+Grant%3BWard%2C+Michael&rft.aulast=Louie&rft.aufirst=Grant&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dysautonomia in Primary Sjogren's Syndrome (pSS) Patients as Assessed in the Outpatient Setting Using Real-Time Digital Autonomic Nervous System Monitoring T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41921080; 5121724 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Nikolov, Nikolay AU - Patel, Ankur AU - Alba, Maria AU - Leakan, Rose AU - Bebris, Lolita AU - Illei, Gabor AU - Ghosh-Dastidar, Samanwoy AU - Colombo, Joe Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Sjogren's syndrome KW - Autonomic nervous system KW - Dysautonomia KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41921080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Dysautonomia+in+Primary+Sjogren%27s+Syndrome+%28pSS%29+Patients+as+Assessed+in+the+Outpatient+Setting+Using+Real-Time+Digital+Autonomic+Nervous+System+Monitoring&rft.au=Nikolov%2C+Nikolay%3BPatel%2C+Ankur%3BAlba%2C+Maria%3BLeakan%2C+Rose%3BBebris%2C+Lolita%3BIllei%2C+Gabor%3BGhosh-Dastidar%2C+Samanwoy%3BColombo%2C+Joe&rft.aulast=Nikolov&rft.aufirst=Nikolay&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real Decisions in Real Time - Helping Patients Make Treatment Decisions, a Patient Perspective T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41920214; 5122025 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Austin, Janet Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Decision making KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41920214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Real+Decisions+in+Real+Time+-+Helping+Patients+Make+Treatment+Decisions%2C+a+Patient+Perspective&rft.au=Austin%2C+Janet&rft.aulast=Austin&rft.aufirst=Janet&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infusion Protocols: National Institutes of Health T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41919375; 5122085 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Hardwick, Donna Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41919375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Infusion+Protocols%3A+National+Institutes+of+Health&rft.au=Hardwick%2C+Donna&rft.aulast=Hardwick&rft.aufirst=Donna&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pharmacokinetics (PK) of Single- and Multiple-Dose Anakinra in Patients with Neonatal-Onset Multisystem Inflammatory Disease (NOMID/CINCA) T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41918018; 5120673 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Penzak, Scott AU - Pham, Tuyet-Hang AU - Pucino, Frank AU - Goldbach-Mansky, Raphaela Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Pharmacokinetics KW - Interleukin 1 receptor antagonist KW - Inflammatory diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41918018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=The+Pharmacokinetics+%28PK%29+of+Single-+and+Multiple-Dose+Anakinra+in+Patients+with+Neonatal-Onset+Multisystem+Inflammatory+Disease+%28NOMID%2FCINCA%29&rft.au=Penzak%2C+Scott%3BPham%2C+Tuyet-Hang%3BPucino%2C+Frank%3BGoldbach-Mansky%2C+Raphaela&rft.aulast=Penzak&rft.aufirst=Scott&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signal Transduction in Th17 Development T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41917765; 5119457 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - O'Shea, John Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Signal transduction KW - Lymphocytes T KW - Helper cells KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41917765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Signal+Transduction+in+Th17+Development&rft.au=O%27Shea%2C+John&rft.aulast=O%27Shea&rft.aufirst=John&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID/CINCA) with the IL-1 blocker, anakinra: after 3 years on treatment T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41917411; 5121137 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Goldbach-Mansky, Raphaela AU - Plass, Nicole AU - Chapelle, Daewn AU - Stone, Deborah AU - Sara, Plehn AU - Kastner, Daniel Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Interleukin 1 KW - Interleukin 1 receptor antagonist KW - Inflammatory diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41917411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Treatment+of+Neonatal-Onset+Multisystem+Inflammatory+Disease+%28NOMID%2FCINCA%29+with+the+IL-1+blocker%2C+anakinra%3A+after+3+years+on+treatment&rft.au=Goldbach-Mansky%2C+Raphaela%3BPlass%2C+Nicole%3BChapelle%2C+Daewn%3BStone%2C+Deborah%3BSara%2C+Plehn%3BKastner%2C+Daniel&rft.aulast=Goldbach-Mansky&rft.aufirst=Raphaela&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Analysis of Gene-Expression Signatures in Peripheral Blood Leukocytes of Patients with Hyperimmunoglobulinemia D with Periodic Fever Syndrome (HIDS) T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41915893; 5120713 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Ryan, John AU - Booty, Matthew AU - Balow, Jr, James AU - Barham, Beverly AU - Sun, Hong-Wei AU - Kastner, Daniel AU - Aksentijevich, Ivona AU - Barron, Karyl Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Gene expression KW - Leukocytes KW - Fever KW - Peripheral blood KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41915893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Identification+and+Analysis+of+Gene-Expression+Signatures+in+Peripheral+Blood+Leukocytes+of+Patients+with+Hyperimmunoglobulinemia+D+with+Periodic+Fever+Syndrome+%28HIDS%29&rft.au=Ryan%2C+John%3BBooty%2C+Matthew%3BBalow%2C+Jr%2C+James%3BBarham%2C+Beverly%3BSun%2C+Hong-Wei%3BKastner%2C+Daniel%3BAksentijevich%2C+Ivona%3BBarron%2C+Karyl&rft.aulast=Ryan&rft.aufirst=John&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ankylosing Spondylitis T2 - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AN - 41913756; 5121005 JF - 2008 Annual Scientific Meeting of the American College of Rheumatology and Association of Rheumatology Health Professionals AU - Guthrie, Lori Y1 - 2008/10/24/ PY - 2008 DA - 2008 Oct 24 KW - Ankylosing spondylitis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.atitle=Ankylosing+Spondylitis&rft.au=Guthrie%2C+Lori&rft.aulast=Guthrie&rft.aufirst=Lori&rft.date=2008-10-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Scientific+Meeting+of+the+American+College+of+Rheumatology+and+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is Epilepsy a progressive disease? - Yes T2 - 2nd World Congress on Controversies in Neurology (CONy 2008) AN - 41710078; 4994301 JF - 2nd World Congress on Controversies in Neurology (CONy 2008) AU - Theodore, W Y1 - 2008/10/23/ PY - 2008 DA - 2008 Oct 23 KW - Epilepsy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41710078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2nd+World+Congress+on+Controversies+in+Neurology+%28CONy+2008%29&rft.atitle=Is+Epilepsy+a+progressive+disease%3F+-+Yes&rft.au=Theodore%2C+W&rft.aulast=Theodore&rft.aufirst=W&rft.date=2008-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2nd+World+Congress+on+Controversies+in+Neurology+%28CONy+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://comtecmed.com/cony/2008/Document.aspx?did=58 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Graphics Processor Approach to Real-Time ML Positioning of Scintillation Events in Continuous Small Field-of-View Scintillation Cameras T2 - 2008 IEEE Nuclear Science Symposium and Medical Imaging Conference and 16th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors AN - 41121740; 4960024 JF - 2008 IEEE Nuclear Science Symposium and Medical Imaging Conference and 16th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors AU - Xi, W. AU - Thada, S AU - Seidel, J AU - Barker, W C AU - Green, M V AU - Choyke, P Y1 - 2008/10/18/ PY - 2008 DA - 2008 Oct 18 KW - Scintillation KW - Cameras KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41121740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+IEEE+Nuclear+Science+Symposium+and+Medical+Imaging+Conference+and+16th+International+Workshop+on+Room-Temperature+Semiconductor+X-ray+and+Gamma-ray+Detectors&rft.atitle=A+Graphics+Processor+Approach+to+Real-Time+ML+Positioning+of+Scintillation+Events+in+Continuous+Small+Field-of-View+Scintillation+Cameras&rft.au=Xi%2C+W.%3BThada%2C+S%3BSeidel%2C+J%3BBarker%2C+W+C%3BGreen%2C+M+V%3BChoyke%2C+P&rft.aulast=Xi&rft.aufirst=W.&rft.date=2008-10-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+IEEE+Nuclear+Science+Symposium+and+Medical+Imaging+Conference+and+16th+International+Workshop+on+Room-Temperature+Semiconductor+X-ray+and+Gamma-ray+Detectors&rft.issn=&rft_id=info:doi/ L2 - http://www.nss-mic.org/2008/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. AN - 69680388; 18831589 AB - High-throughput screening of National Cancer Institute libraries of synthetic and natural compounds identified the vinylogous ureas 2-amino-5,6,7,8-tetrahydro-4 H-cyclohepta[ b]thiophene-3-carboxamide (NSC727447) and N-[3-(aminocarbonyl)-4,5-dimethyl-2-thienyl]-2-furancarboxamide (NSC727448) as inhibitors of the ribonuclease H (RNase H) activity of HIV-1 and HIV-2 reverse transcriptase (RT). A Yonetani-Theorell analysis demonstrated that NSC727447, and the active-site hydroxytropolone RNase H inhibitor beta-thujaplicinol were mutually exclusive in their interaction with the RNase H domain. Mass spectrometric protein footprinting of the NSC727447 binding site indicated that residues Cys280 and Lys281 in helix I of the thumb subdomain of p51 were affected by ligand binding. Although DNA polymerase and pyrophosphorolysis activities of HIV-1 RT were less sensitive to inhibition by NSC727447, protein footprinting indicated that NSC727447 occupied the equivalent region of the p66 thumb. Site-directed mutagenesis using reconstituted p66/p51 heterodimers substituted with natural or non-natural amino acids indicates that altering the p66 RNase H primer grip significantly affects inhibitor sensitivity. NSC727447 thus represents a novel class of RNase H antagonists with a mechanism of action differing from active site, divalent metal-chelating inhibitors that have been reported. JF - ACS chemical biology AU - Wendeler, Michaela AU - Lee, Hsiu-Fang AU - Bermingham, Alun AU - Miller, Jennifer T AU - Chertov, Oleg AU - Bona, Marion K AU - Baichoo, Noel S AU - Ehteshami, Maryam AU - Beutler, John AU - O'Keefe, Barry R AU - Götte, Matthias AU - Kvaratskhelia, Mamuka AU - Le Grice, Stuart AD - HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA. Y1 - 2008/10/17/ PY - 2008 DA - 2008 Oct 17 SP - 635 EP - 644 VL - 3 IS - 10 KW - Furans KW - 0 KW - NSC 727447 KW - NSC 727448 KW - Reverse Transcriptase Inhibitors KW - Thiophenes KW - Urea KW - 8W8T17847W KW - reverse transcriptase, Human immunodeficiency virus 1 KW - EC 2.7.7.- KW - reverse transcriptase, Human immunodeficiency virus 2 KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - Ribonuclease H, Human Immunodeficiency Virus KW - EC 3.1.26.4 KW - Index Medicus KW - Humans KW - Combinatorial Chemistry Techniques KW - Binding Sites KW - Reverse Transcriptase Inhibitors -- chemistry KW - Furans -- pharmacology KW - Thiophenes -- chemistry KW - Furans -- chemistry KW - Ribonuclease H, Human Immunodeficiency Virus -- antagonists & inhibitors KW - Reverse Transcriptase Inhibitors -- pharmacology KW - Thiophenes -- pharmacology KW - HIV Reverse Transcriptase -- antagonists & inhibitors KW - HIV Reverse Transcriptase -- chemistry KW - Ribonuclease H, Human Immunodeficiency Virus -- chemistry KW - Urea -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69680388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+chemical+biology&rft.atitle=Vinylogous+ureas+as+a+novel+class+of+inhibitors+of+reverse+transcriptase-associated+ribonuclease+H+activity.&rft.au=Wendeler%2C+Michaela%3BLee%2C+Hsiu-Fang%3BBermingham%2C+Alun%3BMiller%2C+Jennifer+T%3BChertov%2C+Oleg%3BBona%2C+Marion+K%3BBaichoo%2C+Noel+S%3BEhteshami%2C+Maryam%3BBeutler%2C+John%3BO%27Keefe%2C+Barry+R%3BG%C3%B6tte%2C+Matthias%3BKvaratskhelia%2C+Mamuka%3BLe+Grice%2C+Stuart&rft.aulast=Wendeler&rft.aufirst=Michaela&rft.date=2008-10-17&rft.volume=3&rft.issue=10&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=ACS+chemical+biology&rft.issn=1554-8937&rft_id=info:doi/10.1021%2Fcb8001039 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 1989 Nov 6;257(2):311-4 [2479577] EMBO J. 1991 Dec;10(12):3905-11 [1718745] J Biol Chem. 1992 Jul 25;267(21):15071-9 [1378844] Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6320-4 [7687065] J Biol Chem. 1994 Jan 14;269(2):1388-93 [7507107] J Mol Biol. 1998 Apr 3;277(3):559-72 [9533880] Prog Biophys Mol Biol. 2005 Jun;88(2):209-31 [15572156] Biochemistry. 2005 Feb 8;44(5):1595-606 [15683243] J Biol Chem. 2005 Mar 4;280(9):7949-55 [15615720] Nucleic Acids Res. 2005;33(4):1249-56 [15741178] Nat Methods. 2006 Apr;3(4):263-5 [16554830] Annu Rev Biophys Biomol Struct. 2006;35:225-49 [16689635] Curr Pharm Des. 2006;12(15):1909-22 [16724956] Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9785-9 [16785423] J Med Chem. 2006 Aug 10;49(16):4834-41 [16884295] Nat Rev Mol Cell Biol. 2006 Oct;7(10):775-82 [16926858] J Virol. 2006 Dec;80(24):12283-92 [17020946] Infect Disord Drug Targets. 2006 Dec;6(4):391-413 [17168804] J Virol. 2007 Jul;81(13):6837-45 [17428874] Chem Biol. 2000 May;7(5):355-64 [10801473] EMBO J. 2001 Mar 15;20(6):1449-61 [11250910] Biochemistry. 2002 Apr 16;41(15):4856-65 [11939780] Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15988-93 [12461175] J Biol Chem. 2003 Jan 31;278(5):2777-80 [12480948] J Virol. 2003 Aug;77(15):8548-54 [12857924] Nucleic Acids Res. 2003 Dec 1;31(23):6852-9 [14627818] Anal Biochem. 2003 Nov 1;322(1):33-9 [14705777] Proc Natl Acad Sci U S A. 2004 May 4;101(18):6894-9 [15118107] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8882-7 [15187228] Anal Biochem. 2004 Aug 15;331(2):296-302 [15265735] Protein Expr Purif. 2004 Nov;38(1):37-44 [15477080] Biochemistry. 1972 Jun 6;11(12):2291-9 [5028497] Methods Enzymol. 1982;87:500-9 [6757651] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/cb8001039 ER - TY - JOUR T1 - Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. AN - 69659845; 18713735 AB - Relatively little is known regarding the role of mitochondrial metabolism in stem cell biology. Here we demonstrate that mouse embryonic stem cells sorted for low and high resting mitochondrial membrane potential (DeltaPsi(m)L and DeltaPsi(m)H) are indistinguishable morphologically and by the expression of pluripotency markers, whereas markedly differing in metabolic rates. Interestingly, DeltaPsi(m)L cells are highly efficient at in vitro mesodermal differentiation yet fail to efficiently form teratomas in vivo, whereas DeltaPsi(m)H cells behave in the opposite fashion. We further demonstrate that DeltaPsi(m) reflects the degree of overall mammalian target of rapamycin (mTOR) activation and that the mTOR inhibitor rapamycin reduces metabolic rate, augments differentiation, and inhibits tumor formation of the mouse embryonic stem cells with a high metabolic rate. Taken together, our results suggest a coupling between intrinsic metabolic parameters and stem cell fate that might form a basis for novel enrichment strategies and therapeutic options. JF - The Journal of biological chemistry AU - Schieke, Stefan M AU - Ma, Mingchao AU - Cao, Liu AU - McCoy, J Philip AU - Liu, Chengyu AU - Hensel, Nancy F AU - Barrett, A John AU - Boehm, Manfred AU - Finkel, Toren AD - Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/10/17/ PY - 2008 DA - 2008 Oct 17 SP - 28506 EP - 28512 VL - 283 IS - 42 SN - 0021-9258, 0021-9258 KW - Protein Kinases KW - EC 2.7.- KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - mTOR protein, mouse KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Protein Kinases -- metabolism KW - Animals KW - Oxygen Consumption KW - Cell Nucleus -- metabolism KW - Oxygen -- metabolism KW - Membrane Potentials KW - Cell Differentiation KW - Mice KW - Mice, SCID KW - Models, Biological KW - Male KW - Cell Line KW - Teratoma -- metabolism KW - Embryonic Stem Cells -- cytology KW - Teratoma -- pathology KW - Mitochondria -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69659845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Mitochondrial+metabolism+modulates+differentiation+and+teratoma+formation+capacity+in+mouse+embryonic+stem+cells.&rft.au=Schieke%2C+Stefan+M%3BMa%2C+Mingchao%3BCao%2C+Liu%3BMcCoy%2C+J+Philip%3BLiu%2C+Chengyu%3BHensel%2C+Nancy+F%3BBarrett%2C+A+John%3BBoehm%2C+Manfred%3BFinkel%2C+Toren&rft.aulast=Schieke&rft.aufirst=Stefan&rft.date=2008-10-17&rft.volume=283&rft.issue=42&rft.spage=28506&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M802763200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Oct 1;20(19):7370-6 [11007895] J Neurosci. 2000 Oct 1;20(19):7377-83 [11007896] Transfusion. 2000 Dec;40(12):1482-8 [11134568] Biophys J. 2001 Aug;81(2):685-96 [11463617] J Clin Invest. 2003 Jul;112(1):126-35 [12840067] Cell. 2003 Oct 31;115(3):281-92 [14636556] Mol Cell Biol. 2004 Aug;24(15):6710-8 [15254238] Development. 2004 Sep;131(18):4623-34 [15342485] Nature. 1990 Feb 15;343(6259):657-9 [1689462] Blood. 1993 Oct 1;82(7):2031-7 [8104535] Development. 1993 Jun;118(2):489-98 [8223275] Mol Cell Biol. 1995 Jan;15(1):141-51 [7799920] Science. 1997 Sep 12;277(5332):1669-72 [9287221] Stem Cells. 2004;22(6):962-71 [15536187] Cell. 2005 Feb 25;120(4):483-95 [15734681] Biochem Soc Trans. 2005 Dec;33(Pt 6):1522-5 [16246160] Dev Cell. 2005 Nov;9(5):617-28 [16256737] Genes Dev. 2006 Mar 1;20(5):557-70 [16510872] J Biol Chem. 2006 Sep 15;281(37):27643-52 [16847060] Cancer Res. 2006 Sep 15;66(18):8927-30 [16982728] Nat Cell Biol. 2007 Feb;9(2):210-7 [17220880] Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5431-6 [17374716] Cell. 2007 May 4;129(3):465-72 [17482542] Nature. 2007 Nov 29;450(7170):736-40 [18046414] J Transl Med. 2008;6:7 [18230169] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M802763200 ER - TY - JOUR T1 - Differential dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk. AN - 69659369; 18715866 AB - The cell surface-expressed gamma chain of the high affinity receptor for IgE (FcepsilonRI) can be phosphorylated on two tyrosine residues of the immunoreceptor tyrosine-based activation motif (ITAM), leading to recruitment and activation of spleen tyrosine kinase (Syk), a kinase that is essential for mast cell signaling and allergic responses. However, it is not known whether preferential phosphorylation or dephosphorylation of the two individual FcRgamma tyrosines (the N-terminal Tyr47 and C-terminal Tyr58) could regulate Syk activation. Herein we report that phosphorylation of only Tyr58 was able to elicit Syk phosphorylation and a weak rise in intracellular calcium, suggesting that Tyr58 phosphorylation may be distinctively important for Syk activation. In vitro and in vivo studies revealed that both Tyr47 and Tyr58 could be similarly phosphorylated. However, mass spectrometric analysis of the phosphorylated FcepsilonRgamma from bone marrow-derived mast cells showed that phosphorylation at Tyr47 was at least 2-fold greater than at Tyr58. This suggested that, once phosphorylated, Tyr58 is preferentially dephosphorylated. In vitro studies demonstrated more efficient dephosphorylation of Tyr58 (by the receptor-associated phosphatases SHP-1 and SHP-2) than of Tyr47. Analysis of Syk binding to wild type and mutant phosphorylated FcepsilonRI revealed that mutation at Tyr58 almost completely ablated Syk binding, whereas mutation at Tyr47 moderately reduced Syk binding. The findings argue for a novel regulatory mechanism, where dephosphorylation of phospho-Tyr58 is likely to promote the down-regulation of Syk activation and suppression of mast cell responses. JF - The Journal of biological chemistry AU - Yamashita, Toshiyuki AU - Suzuki, Ryo AU - Backlund, Peter S AU - Yamashita, Yumi AU - Yergey, Alfred L AU - Rivera, Juan AD - Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/10/17/ PY - 2008 DA - 2008 Oct 17 SP - 28584 EP - 28594 VL - 283 IS - 42 SN - 0021-9258, 0021-9258 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - Receptors, IgG KW - Tyrosine KW - 42HK56048U KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - SYK protein, human KW - EC 2.7.10.2 KW - Syk Kinase KW - Syk protein, mouse KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Mice, Transgenic KW - Models, Biological KW - Protein Binding KW - Mutagenesis, Site-Directed KW - Amino Acid Motifs KW - Phosphorylation KW - Protein Structure, Tertiary KW - Mutation KW - Signal Transduction KW - Tyrosine -- chemistry KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Receptors, IgG -- chemistry KW - Protein-Tyrosine Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69659369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Differential+dephosphorylation+of+the+FcRgamma+immunoreceptor+tyrosine-based+activation+motif+tyrosines+with+dissimilar+potential+for+activating+Syk.&rft.au=Yamashita%2C+Toshiyuki%3BSuzuki%2C+Ryo%3BBacklund%2C+Peter+S%3BYamashita%2C+Yumi%3BYergey%2C+Alfred+L%3BRivera%2C+Juan&rft.aulast=Yamashita&rft.aufirst=Toshiyuki&rft.date=2008-10-17&rft.volume=283&rft.issue=42&rft.spage=28584&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M802679200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2004 Aug 1;173(3):1811-8 [15265912] J Biol Chem. 1994 Sep 2;269(35):22427-32 [8071371] Nature. 1976 Dec 9;264(5586):548-50 [826833] J Immunol. 1980 Jun;124(6):2728-37 [7373045] Mol Immunol. 1988 Jul;25(7):647-61 [2971137] Nature. 1991 Oct 31;353(6347):855-8 [1834946] EMBO J. 1993 Feb;12(2):779-86 [8382611] J Biol Chem. 1993 Nov 5;268(31):23318-24 [7693687] Cell. 1994 Feb 11;76(3):519-29 [8313472] Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11246-50 [7526393] Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11251-5 [7526394] J Immunol. 1995 Dec 1;155(11):5330-6 [7594547] Cell. 1996 Jun 28;85(7):985-95 [8674126] J Exp Med. 1996 Jul 1;184(1):71-9 [8691151] J Biol Chem. 1996 Oct 11;271(41):25308-15 [8810294] J Biol Chem. 1996 Nov 1;271(44):27962-8 [8910399] Oncogene. 1996 Dec 19;13(12):2595-605 [9000133] Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1919-24 [9050880] Curr Opin Cell Biol. 1997 Apr;9(2):193-204 [9069265] J Immunol. 1997 Nov 1;159(9):4426-34 [9379041] EMBO J. 1998 Dec 15;17(24):7311-9 [9857188] J Biol Chem. 2004 Nov 19;279(47):49177-87 [15355979] Trends Immunol. 2005 Apr;26(4):208-14 [15797511] Curr Opin Immunol. 2005 Dec;17(6):662-9 [16214316] Biochem Biophys Res Commun. 2007 Dec 7;364(1):111-7 [17936247] Biochim Biophys Acta. 2007 Dec;1774(12):1493-9 [18021750] J Immunol. 2000 Jan 1;164(1):338-44 [10605028] J Immunol. 2000 Feb 1;164(3):1521-8 [10640770] Immunity. 2000 May;12(5):525-35 [10843385] EMBO J. 2001 Dec 17;20(24):7085-95 [11742985] Immunol Lett. 2002 Jun 3;82(1-2):17-21 [12008029] Blood. 2002 Sep 15;100(6):2138-44 [12200378] Mol Immunol. 2002 Sep;38(16-18):1229-33 [12217388] Curr Opin Immunol. 2002 Dec;14(6):688-93 [12413516] J Leukoc Biol. 2003 Jun;73(6):823-9 [12773515] J Exp Med. 2003 Jun 2;197(11):1453-65 [12782712] J Biol Chem. 2004 Oct 29;279(44):45782-90 [15339926] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12911-6 [14569021] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M802679200 ER - TY - CPAPER T1 - New Frontiers in Genomic Research T2 - 5th Annual Biotechnology and Bioinformatics Symposium (BIOT 2008) AN - 42067283; 4978556 JF - 5th Annual Biotechnology and Bioinformatics Symposium (BIOT 2008) AU - Elnitski, Laura Y1 - 2008/10/17/ PY - 2008 DA - 2008 Oct 17 KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42067283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Biotechnology+and+Bioinformatics+Symposium+%28BIOT+2008%29&rft.atitle=New+Frontiers+in+Genomic+Research&rft.au=Elnitski%2C+Laura&rft.aulast=Elnitski&rft.aufirst=Laura&rft.date=2008-10-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Biotechnology+and+Bioinformatics+Symposium+%28BIOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biotconf.org/2008/schedule2008.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - DNA Sequences in gal Operon Override Transcription Elongation Blocks AN - 19805135; 8578453 AB - The DNA loop that represses transcription from galactose (gal) promoters is infrequently formed in stationary-phase cells because the concentration of the loop architectural protein HU is significantly low at that state, resulting in expression of the operon in the absence of the gal inducer d-galactose. Unexpectedly, transcription from the gal promoters under these conditions overrides physical block because of the presence of the Gal repressor bound to an internal operator (O sub(I)) located downstream of the promoters. We have shown here that although a stretch of pyrimidine residues (UUCU) in the RNA:DNA hybrid located immediately upstream of O sub(I) weakens the RNA:DNA hybrid and favors RNA polymerase (RNAP) pausing and backtracking, a stretch of purines (GAGAG) in the RNA present immediately upstream of the pause sequence in the hybrid acts as an antipause element by stabilizing the RNA:DNA duplex and preventing backtracking. This facilitates forward translocation of RNAP, including overriding of the DNA-bound Gal repressor barrier at O sub(I). When the GAGAG sequence is separated from the pyrimidine sequence by a 5-bp DNA insertion, RNAP backtracking is favored from a weak hybrid to a more stable hybrid. RNAP backtracking is sensitive to Gre factors, d-galactose, and antisense oligonucleotides. The ability of a native DNA sequence to override transcription elongation blocks in the gal operon uncovers a previously unknown way of regulating gal metabolism in Escherichia coli. It also explains the synthesis of gal enzymes in the absence of inducer for biosynthetic reactions. JF - Journal of Molecular Biology AU - Lewis, DEA AU - Komissarova, N AU - Le, P AU - Kashlev, M AU - Adhya, S AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA, aed@helix.nih.gov Y1 - 2008/10/17/ PY - 2008 DA - 2008 Oct 17 SP - 843 EP - 858 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 382 IS - 4 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Galactose KW - Nucleotide sequence KW - D-Galactose KW - Enzymes KW - purines KW - Operators KW - Antisense oligonucleotides KW - Promoters KW - DNA-directed RNA polymerase KW - Transcription elongation KW - Hybrids KW - Escherichia coli KW - pyrimidines KW - Operons KW - Repressors KW - Translocation KW - Metabolism KW - Galactose operon KW - N 14815:Nucleotide Sequence KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19805135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=DNA+Sequences+in+gal+Operon+Override+Transcription+Elongation+Blocks&rft.au=Lewis%2C+DEA%3BKomissarova%2C+N%3BLe%2C+P%3BKashlev%2C+M%3BAdhya%2C+S&rft.aulast=Lewis&rft.aufirst=DEA&rft.date=2008-10-17&rft.volume=382&rft.issue=4&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2008.07.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Galactose; Nucleotide sequence; D-Galactose; Enzymes; purines; Operators; Promoters; Antisense oligonucleotides; DNA-directed RNA polymerase; Transcription elongation; Hybrids; pyrimidines; Operons; Translocation; Repressors; Galactose operon; Metabolism; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2008.07.060 ER - TY - CPAPER T1 - Glycans in the Progression of HCV Infection to Hepatocellular Carcinoma T2 - 3rd Annual European Biomarkers Summit Conference AN - 42078178; 4981145 JF - 3rd Annual European Biomarkers Summit Conference AU - Goldman, Radoslav Y1 - 2008/10/16/ PY - 2008 DA - 2008 Oct 16 KW - Infection KW - Hepatocellular carcinoma KW - Polysaccharides KW - Tumors KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42078178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Annual+European+Biomarkers+Summit+Conference&rft.atitle=Glycans+in+the+Progression+of+HCV+Infection+to+Hepatocellular+Carcinoma&rft.au=Goldman%2C+Radoslav&rft.aulast=Goldman&rft.aufirst=Radoslav&rft.date=2008-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Annual+European+Biomarkers+Summit+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.selectbiosciences.com/conferences/EBS2008/Agenda.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Von Hippel-Lindau-coupled and transcription-coupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin. AN - 69676206; 18927284 AB - Ecteinascidin 743 (Et743; trabectedin, Yondelis) has recently been approved in Europe for the treatment of soft tissue sarcomas and is undergoing clinical trials for other solid tumors. Et743 selectively targets cells proficient for TC-NER, which sets it apart from other DNA alkylating agents. In the present study, we examined the effects of Et743 on RNA Pol II. We report that Et743 induces the rapid and massive degradation of transcribing Pol II in various cancer cell lines and normal fibroblasts. Pol II degradation was abrogated by the proteasome inhibitor MG132 and was dependent on TC-NER. Cockayne syndrome (CS) cells and xeroderma pigmentosum (XP) cells (XPD, XPA, XPG, and XPF) were defective in Pol II degradation, whereas XPC cells whose defect is limited to global genome NER in nontranscribing regions were proficient for Pol II degradation. Complementation of the CSB and XPD cells restored Pol II degradation. We also show that cells defective for the VHL complex were defective in Pol II degradation and that complementation of those cells restores Pol II degradation. Moreover, VHL deficiency rendered cells resistant to Et743-induced cell death, a similar effect to that of TC-NER deficiency. These results suggest that both TC-NER-induced and VHL-mediated Pol II degradation play a role in cell killing by Et743. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Aune, Gregory J AU - Takagi, Kazutaka AU - Sordet, Olivier AU - Guirouilh-Barbat, Josée AU - Antony, Smitha AU - Bohr, Vilhelm A AU - Pommier, Yves AD - Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 SP - 6449 EP - 6455 VL - 14 IS - 20 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Cysteine Proteinase Inhibitors KW - DNA-Binding Proteins KW - Dioxoles KW - Leupeptins KW - Tetrahydroisoquinolines KW - XPC protein, human KW - 156533-34-5 KW - Von Hippel-Lindau Tumor Suppressor Protein KW - EC 2.3.2.27 KW - RNA Polymerase II KW - EC 2.7.7.- KW - DNA Helicases KW - EC 3.6.4.- KW - ERCC6 protein, human KW - EC 3.6.4.12 KW - Xeroderma Pigmentosum Group D Protein KW - ERCC2 protein, human KW - EC 5.99.- KW - VHL protein, human KW - EC 6.3.2.- KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - trabectedin KW - ID0YZQ2TCP KW - benzyloxycarbonylleucyl-leucyl-leucine aldehyde KW - RF1P63GW3K KW - Index Medicus KW - von Hippel-Lindau Disease -- enzymology KW - Humans KW - DNA-Binding Proteins -- genetics KW - Xeroderma Pigmentosum -- genetics KW - Xeroderma Pigmentosum -- pathology KW - Cysteine Proteinase Inhibitors -- pharmacology KW - Leupeptins -- pharmacology KW - Xeroderma Pigmentosum Group D Protein -- genetics KW - Xeroderma Pigmentosum -- enzymology KW - Cell Survival -- drug effects KW - Cockayne Syndrome -- genetics KW - von Hippel-Lindau Disease -- genetics KW - DNA Helicases -- genetics KW - Genetic Complementation Test KW - Sarcoma -- enzymology KW - Sarcoma -- pathology KW - DNA-Binding Proteins -- metabolism KW - DNA Repair Enzymes -- metabolism KW - DNA Helicases -- metabolism KW - Xeroderma Pigmentosum -- metabolism KW - Fibroblasts -- metabolism KW - Cockayne Syndrome -- pathology KW - DNA Damage -- drug effects KW - Phosphorylation -- drug effects KW - Blotting, Western KW - von Hippel-Lindau Disease -- pathology KW - DNA Repair Enzymes -- genetics KW - Cells, Cultured KW - Sarcoma -- genetics KW - Cockayne Syndrome -- enzymology KW - Xeroderma Pigmentosum Group D Protein -- metabolism KW - RNA Polymerase II -- metabolism KW - Transcription, Genetic -- drug effects KW - Neoplasms -- pathology KW - Neoplasms -- enzymology KW - RNA Polymerase II -- genetics KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Von Hippel-Lindau Tumor Suppressor Protein -- genetics KW - Tetrahydroisoquinolines -- pharmacology KW - Von Hippel-Lindau Tumor Suppressor Protein -- metabolism KW - Dioxoles -- pharmacology KW - Neoplasms -- genetics KW - DNA Repair -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69676206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Von+Hippel-Lindau-coupled+and+transcription-coupled+nucleotide+excision+repair-dependent+degradation+of+RNA+polymerase+II+in+response+to+trabectedin.&rft.au=Aune%2C+Gregory+J%3BTakagi%2C+Kazutaka%3BSordet%2C+Olivier%3BGuirouilh-Barbat%2C+Jos%C3%A9e%3BAntony%2C+Smitha%3BBohr%2C+Vilhelm+A%3BPommier%2C+Yves&rft.aulast=Aune&rft.aufirst=Gregory&rft.date=2008-10-15&rft.volume=14&rft.issue=20&rft.spage=6449&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-0730 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-16 N1 - Date created - 2008-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2001 Oct;7(10):3251-7 [11595721] Clin Cancer Res. 2001 Sep;7(9):2908-11 [11555609] Chem Biol. 2001 Dec;8(12):1151-60 [11755394] Nucleic Acids Res. 2002 Feb 1;30(3):782-93 [11809892] Oncologist. 2002;7(3):210-6 [12065793] Cancer Res. 2002 Jun 15;62(12):3377-81 [12067978] Anticancer Drugs. 2002 Jul;13(6):545-55 [12172500] Cancer Res. 2002 Sep 1;62(17):4899-902 [12208738] Clin Cancer Res. 2002 Dec;8(12):3893-903 [12473605] Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2706-11 [12604794] Nat Rev Mol Cell Biol. 2003 May;4(5):361-72 [12728270] EMBO J. 2003 Aug 15;22(16):4249-59 [12912922] J Biol Chem. 2004 Feb 27;279(9):8190-5 [14662762] Annu Rev Biochem. 2004;73:39-85 [15189136] Proc Natl Acad Sci U S A. 1986 Dec;83(23):8878-82 [3466163] J Biol Chem. 1991 Feb 5;266(4):2297-302 [1989983] J Nat Prod. 1990 Jul-Aug;53(4):771-92 [2095373] Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11456-60 [1454834] J Biomol Struct Dyn. 1993 Apr;10(5):793-818 [8318161] J Cell Physiol. 1994 Mar;158(3):417-26 [8126066] Biochemistry. 1996 Oct 15;35(41):13303-9 [8873596] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11586-90 [8876179] J Biol Chem. 1998 Feb 27;273(9):5184-9 [9478972] Clin Cancer Res. 1998 Aug;4(8):1977-83 [9717828] Ann Oncol. 1998 Sep;9(9):981-7 [9818072] Genes Dev. 1999 Apr 1;13(7):768-85 [10197977] J Med Chem. 1999 Jul 15;42(14):2493-7 [10411470] Mol Cell Biol. 1999 Sep;19(9):5902-12 [10454537] J Clin Oncol. 2004 Dec 15;22(24):4991-5004 [15611513] Trends Pharmacol Sci. 2005 Mar;26(3):138-45 [15749159] Prog Nucleic Acid Res Mol Biol. 2005;79:183-235 [16096029] Curr Opin Oncol. 2006 Jul;18(4):347-53 [16721129] Cancer Res. 2006 Aug 15;66(16):8155-62 [16912194] Nat Rev Mol Cell Biol. 2006 Aug;7(8):557-67 [16936696] Mol Syst Biol. 2006;2:51 [17016517] Genes Dev. 2006 Nov 1;20(21):2922-36 [17079683] Science. 2007 Feb 9;315(5813):859-62 [17290000] Mol Cell Biol. 2007 Apr;27(8):3211-6 [17296727] Trends Biochem Sci. 2007 Apr;32(4):165-71 [17349792] Curr Opin Cell Biol. 2007 Dec;19(6):685-90 [18006292] Science. 2007 Dec 14;318(5857):1735-6 [18079391] Science. 2007 Dec 14;318(5857):1780-2 [18079404] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6775-9 [10841572] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6780-4 [10841573] Int J Cancer. 2001 May 15;92(4):583-8 [11304695] Nat Med. 2001 May;7(5):584-90 [11329060] Nature. 2001 May 17;411(6835):366-74 [11357144] J Am Chem Soc. 2001 Jul 11;123(27):6485-95 [11439034] Nat Med. 2001 Aug;7(8):961-6 [11479630] Chem Biol. 2001 Nov;8(11):1033-49 [11731295] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-0730 ER - TY - JOUR T1 - Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics. AN - 69669578; 18922899 AB - Arsenic is a carcinogen with transplacental activity that can affect human skin stem cell population dynamics in vitro by blocking exit into differentiation pathways. Keratinocyte stem cells (KSC) are probably a key target in skin carcinogenesis. Thus, we tested the effects of fetal arsenic exposure in Tg.AC mice, a strain sensitive to skin carcinogenesis via activation of the v-Ha-ras transgene likely in KSCs. After fetal arsenic treatment, offspring received topical 12-O-tetradecanoyl phorbol-13-acetate (TPA) through adulthood. Arsenic alone had no effect, whereas TPA alone induced papillomas and squamous cell carcinomas (SCC). However, fetal arsenic treatment before TPA increased SCC multiplicity 3-fold more than TPA alone, and these SCCs were much more aggressive (invasive, etc.). Tumor v-Ha-ras levels were 3-fold higher with arsenic plus TPA than TPA alone, and v-Ha-ras was overexpressed early on in arsenic-treated fetal skin. CD34, considered a marker for both KSCs and skin cancer stem cells, and Rac1, a key gene stimulating KSC self-renewal, were greatly increased in tumors produced by arsenic plus TPA exposure versus TPA alone, and both were elevated in arsenic-treated fetal skin. Greatly increased numbers of CD34-positive probable cancer stem cells and marked overexpression of RAC1 protein occurred in tumors induced by arsenic plus TPA compared with TPA alone. Thus, fetal arsenic exposure, although by itself oncogenically inactive in skin, facilitated cancer response in association with distorted skin tumor stem cell signaling and population dynamics, implicating stem cells as a target of arsenic in the fetal basis of skin cancer in adulthood. JF - Cancer research AU - Waalkes, Michael P AU - Liu, Jie AU - Germolec, Dori R AU - Trempus, Carol S AU - Cannon, Ronald E AU - Tokar, Erik J AU - Tennant, Raymond W AU - Ward, Jerrold M AU - Diwan, Bhalchandra A AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, North Carolina27709, USA. waalkes@niehs.nih.gov Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 SP - 8278 EP - 8285 VL - 68 IS - 20 KW - Antigens, CD34 KW - 0 KW - Neuropeptides KW - Proteins KW - Rac1 protein, mouse KW - Shfdg1 protein, mouse KW - rac GTP-Binding Proteins KW - EC 3.6.5.2 KW - rac1 GTP-Binding Protein KW - Arsenic KW - N712M78A8G KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Tetradecanoylphorbol Acetate -- toxicity KW - Animals KW - Carcinoma, Squamous Cell -- chemically induced KW - Mice KW - rac GTP-Binding Proteins -- analysis KW - Pregnancy KW - Genes, ras KW - Neuropeptides -- analysis KW - Antigens, CD34 -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Antigens, CD34 -- analysis KW - Female KW - rac GTP-Binding Proteins -- genetics KW - Neuropeptides -- genetics KW - Skin Neoplasms -- genetics KW - Fetus -- drug effects KW - Arsenic -- toxicity KW - Skin Neoplasms -- chemically induced KW - Neoplastic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69669578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Arsenic+exposure+in+utero+exacerbates+skin+cancer+response+in+adulthood+with+contemporaneous+distortion+of+tumor+stem+cell+dynamics.&rft.au=Waalkes%2C+Michael+P%3BLiu%2C+Jie%3BGermolec%2C+Dori+R%3BTrempus%2C+Carol+S%3BCannon%2C+Ronald+E%3BTokar%2C+Erik+J%3BTennant%2C+Raymond+W%3BWard%2C+Jerrold+M%3BDiwan%2C+Bhalchandra+A&rft.aulast=Waalkes&rft.aufirst=Michael&rft.date=2008-10-15&rft.volume=68&rft.issue=20&rft.spage=8278&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-2099 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-07 N1 - Date created - 2008-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] Nature. 2008 Apr 3;452(7187):650-3 [18385740] Curr Biol. 2001 Apr 17;11(8):558-68 [11369200] J Biol Chem. 2003 Jan 17;278(3):1758-68 [12419822] J Invest Dermatol. 2003 Apr;120(4):501-11 [12648211] Nat Rev Cancer. 2003 Jun;3(6):434-43 [12778133] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):394-404 [15276419] Am J Pathol. 1993 Apr;142(4):1199-207 [8475993] Carcinogenesis. 1996 Sep;17(9):1825-33 [8824502] Mutat Res. 1997 Jun;386(3):209-18 [9219559] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] Mol Carcinog. 1998 Apr;21(4):244-50 [9585254] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] Nature. 2004 Nov 18;432(7015):324-31 [15549094] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Toxicol Appl Pharmacol. 2005 Aug 22;207(1):69-77 [16054901] Science. 2005 Aug 5;309(5736):933-5 [16081735] Oncogene. 2005 Dec 15;24(56):8217-28 [16355251] Cancer Lett. 2006 Jan 18;231(2):326-38 [15893875] Mol Carcinog. 2006 Feb;45(2):126-40 [16329151] Cancer Res. 2006 Feb 15;66(4):1883-90; discussion 1895-6 [16488983] Semin Fetal Neonatal Med. 2006 Apr;11(2):73-8 [16368278] Cell. 2006 Mar 24;124(6):1111-5 [16564000] Environ Health Perspect. 2006 Aug;114(8):1293-6 [16882542] Stem Cell Rev. 2005;1(3):225-31 [17142859] Hepatology. 2007 Jan;45(1):205-12 [17187425] J Intern Med. 2007 May;261(5):412-7 [17444880] Reprod Toxicol. 2007 Apr-May;23(3):297-307 [17046196] Cancer Res. 2007 May 1;67(9):4173-81 [17483328] Toxicol Appl Pharmacol. 2007 May 15;221(1):119-28 [17400267] C R Biol. 2007 Jun-Jul;330(6-7):465-73 [17631439] Mol Carcinog. 2007 Aug;46(8):605-10 [17538943] Mol Carcinog. 2007 Aug;46(8):579-84 [17583566] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80 [17306315] Oncogene. 2007 Oct 18;26(48):6885-95 [17525749] Microsc Res Tech. 2001 Jan 15;52(2):190-203 [11169867] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-2099 ER - TY - JOUR T1 - Treatment of malignant pheochromocytoma/paraganglioma with cyclophosphamide, vincristine, and dacarbazine: recommendation from a 22-year follow-up of 18 patients. AN - 69654211; 18780317 AB - A long-term follow-up was conducted of 18 patients with a diagnosis of pheochromocytoma/paraganglioma treated with a combination of cyclophosphamide, vincristine, and dacarbazine (CVD). The study design was a nonrandomized, single-arm trial conducted at a government medical referral center. Eighteen patients with metastatic malignant pheochromocytoma/paraganglioma were studied. After controlling symptoms of catecholamine excess, patients were treated with cyclophosphamide at 750 mg/m(2), vincristine at 1.4 mg/m(2), and dacarbazine at 600 mg/m(2) on Day 1 and dacarbazine at 600 mg/m(2) on Day 2, every 21 to 28 days. Combination chemotherapy with CVD produced a complete response rate of 11% and a partial response rate of 44%. Median survival from a landmark was 3.8 years for patients whose tumors responded to therapy and 1.8 years for patients whose tumors did not respond (P = .65). All patients with tumors scored as responding reported improvement in their symptoms related to excessive catecholamine release and had objective improvements in blood pressure. CVD was well tolerated with only grade I/II toxicities. Combination chemotherapy with CVD produced objective tumor responses in patients with advanced malignant pheochromocytoma/paraganglioma. In this 22-year follow-up there was no difference in overall survival between patients whose tumors objectively shrank and those with stable or progressive disease. However, patients reported improvement in symptoms, had objective improvements in blood pressure, and had tumor shrinkage that made surgical resection possible. The authors conclude that CVD therapy is not indicated in every patient with metastatic pheochromocytoma/paraganglioma, but should be considered in the management of patients with symptoms and where tumor shrinkage might be beneficial. (c) 2008 American Cancer Society. JF - Cancer AU - Huang, Hui AU - Abraham, Jame AU - Hung, Elizabeth AU - Averbuch, Steven AU - Merino, Maria AU - Steinberg, Seth M AU - Pacak, Karel AU - Fojo, Tito AD - Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 SP - 2020 EP - 2028 VL - 113 IS - 8 SN - 0008-543X, 0008-543X KW - Vincristine KW - 5J49Q6B70F KW - Dacarbazine KW - 7GR28W0FJI KW - Cyclophosphamide KW - 8N3DW7272P KW - Abridged Index Medicus KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Vincristine -- adverse effects KW - Humans KW - Vincristine -- administration & dosage KW - Child KW - Dacarbazine -- adverse effects KW - Cyclophosphamide -- adverse effects KW - Kaplan-Meier Estimate KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Dacarbazine -- administration & dosage KW - Follow-Up Studies KW - Adolescent KW - Female KW - Male KW - Pheochromocytoma -- mortality KW - Pheochromocytoma -- drug therapy KW - Adrenal Gland Neoplasms -- pathology KW - Pheochromocytoma -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Adrenal Gland Neoplasms -- mortality KW - Adrenal Gland Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69654211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Treatment+of+malignant+pheochromocytoma%2Fparaganglioma+with+cyclophosphamide%2C+vincristine%2C+and+dacarbazine%3A+recommendation+from+a+22-year+follow-up+of+18+patients.&rft.au=Huang%2C+Hui%3BAbraham%2C+Jame%3BHung%2C+Elizabeth%3BAverbuch%2C+Steven%3BMerino%2C+Maria%3BSteinberg%2C+Seth+M%3BPacak%2C+Karel%3BFojo%2C+Tito&rft.aulast=Huang&rft.aufirst=Hui&rft.date=2008-10-15&rft.volume=113&rft.issue=8&rft.spage=2020&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.23812 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.23812 ER - TY - JOUR T1 - Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities. AN - 69591973; 18706386 AB - We previously described many Hsp70 Ssa1p mutants that impair [PSI(+)] prion propagation in yeast without affecting cell growth. To determine how the mutations alter Hsp70 we analyzed biochemically the substrate-binding domain (SBD) mutant L483W and the nucleotide-binding domain (NBD) mutants A17V and R34K. Ssa1(L483W) ATPase activity was elevated 10-fold and was least stimulated by substrates or Hsp40 co-chaperones. Ssa1(A17V) and Ssa1(R34K) ATPase activities were nearly wild type but both showed increased stimulation by substrates. Peptide binding and reactivation of denatured luciferase were enhanced in Ssa1(A17V) and Ssa1(R34K) but compromised in Ssa1(L483W). The nucleotide exchange factor Fes1 influenced ATPase of wild type Ssa1 and each mutant differently. Partial protease digestion uncovered similar and distinct conformational changes of the substrate-binding domain among the three mutants. Our data suggest that prion-impairing mutations of Ssa1 can increase or decrease substrate interactions, alter the Hsp70 reaction cycle at different points and impair normal NBD-SBD cooperation. JF - Archives of biochemistry and biophysics AU - Needham, Patrick G AU - Masison, Daniel C AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Building 8, Room 407, LBG/NIDDK, Bethesda, MD 20892-0851, USA. Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 SP - 167 EP - 174 VL - 478 IS - 2 KW - HSP70 Heat-Shock Proteins KW - 0 KW - Molecular Chaperones KW - Prions KW - Recombinant Proteins KW - Saccharomyces cerevisiae Proteins KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - SSA1 protein, S cerevisiae KW - EC 3.6.1.3 KW - Index Medicus KW - Molecular Chaperones -- chemistry KW - Molecular Chaperones -- genetics KW - Genes, Fungal KW - Molecular Chaperones -- metabolism KW - Models, Molecular KW - Recombinant Proteins -- genetics KW - Saccharomyces cerevisiae -- genetics KW - Mutagenesis, Site-Directed KW - Saccharomyces cerevisiae -- metabolism KW - Recombinant Proteins -- metabolism KW - Binding Sites -- genetics KW - Recombinant Proteins -- chemistry KW - Protein Structure, Tertiary KW - Amino Acid Substitution KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Prions -- genetics KW - HSP70 Heat-Shock Proteins -- metabolism KW - HSP70 Heat-Shock Proteins -- genetics KW - HSP70 Heat-Shock Proteins -- chemistry KW - Saccharomyces cerevisiae Proteins -- genetics KW - Adenosine Triphosphatases -- metabolism KW - Adenosine Triphosphatases -- chemistry KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Prions -- metabolism KW - Adenosine Triphosphatases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69591973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Prion-impairing+mutations+in+Hsp70+chaperone+Ssa1%3A+effects+on+ATPase+and+chaperone+activities.&rft.au=Needham%2C+Patrick+G%3BMasison%2C+Daniel+C&rft.aulast=Needham&rft.aufirst=Patrick&rft.date=2008-10-15&rft.volume=478&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=1096-0384&rft_id=info:doi/10.1016%2Fj.abb.2008.07.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-06 N1 - Date created - 2008-09-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 1998 Jul 10;94(1):73-82 [9674429] J Biol Chem. 1998 Oct 23;273(43):27824-30 [9774392] J Biol Chem. 1998 Dec 4;273(49):32883-8 [9830037] Mol Cell. 1998 Nov;2(5):593-603 [9844632] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15253-8 [9860955] Biochemistry. 1999 Mar 30;38(13):4165-76 [10194333] Proc Natl Acad Sci U S A. 1999 May 11;96(10):5452-7 [10318904] Mol Cell Biol. 1999 Dec;19(12):8103-12 [10567536] Nat Struct Biol. 2000 Jul;7(7):586-93 [10876246] Genetics. 2007 Nov;177(3):1583-93 [18039878] Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1164-9 [18203820] PLoS One. 2008;3(3):e1763 [18335038] Nat Genet. 2008 Apr;40(4):460-5 [18362884] J Biol Chem. 1995 Jul 14;270(28):16903-10 [7622507] Cell. 2003 Jan 10;112(1):41-50 [12526792] FEBS Lett. 1995 Jul 24;368(3):435-40 [7635193] J Biol Chem. 1996 May 10;271(19):11236-46 [8626673] Science. 1996 Jun 14;272(5268):1606-14 [8658133] Science. 1997 Apr 18;276(5311):431-5 [9103205] Biochemistry. 1998 May 5;37(18):6586-97 [9572876] J Biol Chem. 2000 Jul 14;275(28):21107-13 [10801805] J Struct Biol. 2000 Jun;130(2-3):310-22 [10940235] Genetics. 2000 Oct;156(2):559-70 [11014806] J Biol Chem. 2001 Mar 2;276(9):6112-8 [11096111] FEBS Lett. 2001 Jan 26;489(1):92-6 [11231020] Nat Struct Biol. 2001 May;8(5):427-32 [11323718] Curr Microbiol. 2001 Jul;43(1):7-10 [11375656] Biochem J. 2002 Jan 1;361(Pt 1):27-34 [11743879] Adv Protein Chem. 2001;59:223-42 [11868273] Science. 2002 Mar 8;295(5561):1852-8 [11884745] Mol Cell Biol. 2002 Jul;22(13):4677-89 [12052876] J Biol Chem. 2002 Jun 28;277(26):23702-8 [11923285] FEBS Lett. 2002 Nov 6;531(2):339-42 [12417338] Genetics. 2003 Feb;163(2):495-506 [12618389] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Mar 25;786(1-2):109-15 [12651006] J Biol Chem. 2003 May 23;278(21):19017-22 [12651857] J Mol Biol. 2004 Feb 6;336(1):275-85 [14741222] Genes Dev. 2004 Mar 1;18(5):470-85 [15037545] Mol Cell Biol. 2004 May;24(9):3928-37 [15082786] Science. 2004 Jun 18;304(5678):1793-7 [15155912] J Biol Chem. 2004 Jul 2;279(27):27957-64 [15102842] J Biol Chem. 2004 Oct 22;279(43):44376-83 [15302880] J Biol Chem. 1979 May 10;254(9):3229-35 [155064] J Biol Chem. 1987 Jan 15;262(2):746-51 [3027066] Mol Cell Biol. 1987 Jul;7(7):2568-77 [3302682] EMBO J. 1989 May;8(5):1461-7 [2670554] Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2874-8 [1826368] J Biol Chem. 1992 Oct 15;267(29):20927-31 [1400408] J Biol Chem. 1994 Apr 1;269(13):9798-804 [8144572] Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10345-9 [7937953] J Biol Chem. 1995 May 5;270(18):10412-9 [7737974] Science. 1995 May 12;268(5212):880-4 [7754373] J Mol Biol. 1995 May 26;249(1):126-37 [7776367] Biochim Biophys Acta. 2004 Nov 29;1695(1-3):171-88 [15571814] Mol Cell. 2005 Feb 4;17(3):367-79 [15694338] Cell Mol Life Sci. 2005 Mar;62(6):670-84 [15770419] Genetics. 2005 Apr;169(4):1873-82 [15687271] Protein Sci. 2005 Jul;14(7):1697-709 [15987899] Mol Cell. 2005 Nov 23;20(4):513-24 [16307916] J Biol Chem. 2005 Dec 16;280(50):41262-9 [16221677] Mol Cell. 2006 Feb 3;21(3):359-67 [16455491] EMBO J. 2006 Feb 22;25(4):822-33 [16467849] Cell. 2006 May 5;125(3):443-51 [16678092] EMBO J. 2006 Jun 7;25(11):2510-8 [16688211] Genetics. 2006 Jun;173(2):611-20 [16582428] Biophys J. 2006 Jul 15;91(2):496-507 [16648174] Curr Top Med Chem. 2006;6(11):1215-25 [16842158] Genetics. 2007 Feb;175(2):621-30 [17151238] J Biol Chem. 2007 Apr 20;282(16):11931-40 [17324933] Mol Biol Cell. 2007 Jun;18(6):2149-54 [17392510] Mol Cell. 2007 Nov 9;28(3):422-33 [17996706] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.abb.2008.07.023 ER - TY - CPAPER T1 - Neurorehabilitation at a Crossroads: From Bench to Bedside T2 - 2008 ACRM-ASNR Joint Educational Conference on Rehabilitation Research Without Borders AN - 42052611; 4974295 DE: JF - 2008 ACRM-ASNR Joint Educational Conference on Rehabilitation Research Without Borders AU - Cohen, Leonardo Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42052611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+ACRM-ASNR+Joint+Educational+Conference+on+Rehabilitation+Research+Without+Borders&rft.atitle=Neurorehabilitation+at+a+Crossroads%3A+From+Bench+to+Bedside&rft.au=Cohen%2C+Leonardo&rft.aulast=Cohen&rft.aufirst=Leonardo&rft.date=2008-10-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+ACRM-ASNR+Joint+Educational+Conference+on+Rehabilitation+Research+Without+Borders&rft.issn=&rft_id=info:doi/ L2 - http://www.acrm.org/annual_conference/Preliminary_Program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms and Therapeutic Applications of Immune Suppressive Oligonucleotides T2 - 4th Annual Meeting of the Oligonucleotide Therapeutics Society AN - 41103048; 4951861 JF - 4th Annual Meeting of the Oligonucleotide Therapeutics Society AU - Klinman, Dennis Marc Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 KW - Oligonucleotides KW - Therapeutic applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41103048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Meeting+of+the+Oligonucleotide+Therapeutics+Society&rft.atitle=Mechanisms+and+Therapeutic+Applications+of+Immune+Suppressive+Oligonucleotides&rft.au=Klinman%2C+Dennis+Marc&rft.aulast=Klinman&rft.aufirst=Dennis&rft.date=2008-10-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Meeting+of+the+Oligonucleotide+Therapeutics+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.nyas.org/pdfs/OTS_File.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Tamoxifen Chemoprevention Treatment and Time to First Diagnosis of Estrogen Receptor-Negative Breast Cancer AN - 19718166; 8641841 AB - Background Tamoxifen's effect of reducing the risk of estrogen receptor (ER)-positive breast cancer is well established. Its effect on the time to first diagnosis of breast cancer has not been reported. We used information from the randomized, placebo-controlled Breast Cancer Prevention Trial (BCPT) to make that evaluation.Methods A total of 13388 women enrolled in BCPT, of whom 174 were diagnosed with ER-positive tumors and 69 were diagnosed with ER-negative tumors. A flexible semiparametric cure rate model was used to assess the effects of tamoxifen vs placebo treatment on the time to disease diagnosis. Multivariable logistic regression, adjusted for age and tumor size at diagnosis, was used to assess the association between the mammography detection rate and treatment with tamoxifen. All statistical tests were two-sided.Results The median times to diagnosis of ER-positive tumors were similar in both treatment groups (43 months for the placebo arm and 51 months for the treatment arm). Times to diagnosis of ER-negative tumors, however, differed between treatment groups, with median times to diagnosis of 36 months in the placebo arm vs 24 months in the tamoxifen arm (difference = 12 months, 95% confidence interval [CI] = 3 to 17 months, P = .037). ER-negative breast cancers in the tamoxifen arm were more likely than those in the placebo arm to be detected by mammography than by clinical breast examination alone after adjustment for age and tumor size, but the increase was only marginally statistically significant (odds ratio for mammography detection = 4.68, 95% CI = 0.86 to 25.32, P = .073). No differences were found in the mammography detection rates for ER-positive tumors by treatment arm.Conclusion Although tamoxifen treatment does not reduce the incidence of ER-negative breast cancer, it may have advanced detection of such tumors by approximately 1 year, compared with that in the placebo arm. The time to diagnosis of ER-positive breast cancer was similar in both treatment arms. JF - Journal of the National Cancer Institute AU - Shen, Yu AU - Costantino, Joseph P AU - Qin, Jing AD - Affiliations of authors: Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, TX (YS); Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA (JPC); Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD (JQ), yshen@mdanderson.org Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 SP - 1448 EP - 1453 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 20 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - risk reduction KW - Age KW - prevention KW - Breast cancer KW - tumors KW - chemotherapy KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19718166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Tamoxifen+Chemoprevention+Treatment+and+Time+to+First+Diagnosis+of+Estrogen+Receptor-Negative+Breast+Cancer&rft.au=Shen%2C+Yu%3BCostantino%2C+Joseph+P%3BQin%2C+Jing&rft.aulast=Shen&rft.aufirst=Yu&rft.date=2008-10-15&rft.volume=100&rft.issue=20&rft.spage=1448&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - risk reduction; Age; prevention; Breast cancer; tumors; chemotherapy; estrogens DO - http://dx.doi.org/10.1093/jnci/djn320 ER - TY - JOUR T1 - Prospective Evaluation of Risk Factors for Male Breast Cancer AN - 19612263; 8641853 AB - Most risk factors for male breast cancer have been derived from retrospective studies that may reflect selective recall. In the prospective National Institutes of Health-AARP Diet and Health Study, we studied 324920 men, among whom 121 developed breast cancer. Men who reported a first-degree relative with breast cancer had an increased risk of breast cancer (relative risk [RR] = 1.92, 95% confidence interval [CI] = 1.19 to 3.09). Among the medical conditions examined, a new finding emerged regarding increased male breast cancer risk associated with a history of a bone fracture (RR = 2.20, 95% CI = 1.24 to 3.91). Obesity was positively related to risk (RR = 1.79, 95% CI = 1.10 to 2.91, for body mass indices of greater than or equal to 30 vs [Lt]25 kg/m2 ) and physical activity inversely related, even after adjustment for body mass index. Smokers were at somewhat elevated risk, although trends with smoking characteristics were inconsistent. Alcohol consumption was not related to risk. The identified risk factors show some commonalities with female breast cancer and indicate the importance of hormonal mechanisms. Differences in risk factors may reflect unique mechanisms associated with androgens and their ratio to bioavailable estrogens. JF - Journal of the National Cancer Institute AU - Brinton, Louise A AU - Richesson, Douglas A AU - Gierach, Gretchen L AU - Lacey, James V AU - Park, Yikyung AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AD - Affiliations of authors: Hormonal and Reproductive Epidemiology Branch (LAB, DAR, GLG, JVL) and Nutritional Epidemiology Branch (YP, AS), Knowledge Management, AARP, Washington, DC (ARH), brinton@nih.gov Y1 - 2008/10/15/ PY - 2008 DA - 2008 Oct 15 SP - 1477 EP - 1481 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 20 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Historical account KW - obesity KW - Smoking KW - Bioavailability KW - body mass KW - physical activity KW - Diets KW - Alcohol KW - males KW - Cancer KW - Bone KW - Breast cancer KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19612263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Prospective+Evaluation+of+Risk+Factors+for+Male+Breast+Cancer&rft.au=Brinton%2C+Louise+A%3BRichesson%2C+Douglas+A%3BGierach%2C+Gretchen+L%3BLacey%2C+James+V%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2008-10-15&rft.volume=100&rft.issue=20&rft.spage=1477&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn329 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Breast cancer; Cancer; body mass; estrogens; Alcohol; Bone; Diets; males; obesity; Historical account; Bioavailability; Smoking; physical activity DO - http://dx.doi.org/10.1093/jnci/djn329 ER - TY - JOUR T1 - Update on blepharospasm: report from the BEBRF International Workshop. AN - 69660872; 18852443 AB - This review updates understanding and research on blepharospasm, a subtype of focal dystonia. Topics covered include clinical aspects, pathology, pathophysiology, animal models, dry eye, photophobia, epidemiology, genetics, and treatment. Blepharospasm should be differentiated from apraxia of eyelid opening. New insights into pathology and pathophysiology are derived from different types of imaging, including magnetic resonance studies. Physiologic studies indicate increased plasticity and trigeminal sensitization. While botulinum neurotoxin injections are the mainstay of therapy, other therapies are on the horizon. JF - Neurology AU - Hallett, Mark AU - Evinger, Craig AU - Jankovic, Joseph AU - Stacy, Mark AU - BEBRF International Workshop AD - Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892-1428, USA. hallettm@ninds.nih.gov ; BEBRF International Workshop Y1 - 2008/10/14/ PY - 2008 DA - 2008 Oct 14 SP - 1275 EP - 1282 VL - 71 IS - 16 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Education KW - Oculomotor Muscles -- physiopathology KW - Apraxias -- physiopathology KW - Humans KW - Photophobia -- physiopathology KW - Dystonic Disorders -- physiopathology KW - Blepharospasm -- epidemiology KW - Blepharospasm -- therapy KW - Blepharospasm -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69660872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Update+on+blepharospasm%3A+report+from+the+BEBRF+International+Workshop.&rft.au=Hallett%2C+Mark%3BEvinger%2C+Craig%3BJankovic%2C+Joseph%3BStacy%2C+Mark%3BBEBRF+International+Workshop&rft.aulast=Hallett&rft.aufirst=Mark&rft.date=2008-10-14&rft.volume=71&rft.issue=16&rft.spage=1275&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/10.1212%2F01.wnl.0000327601.46315.85 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-27 N1 - Date created - 2008-10-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurol. 2002 Jan;249(1):64-8 [11954870] Arch Neurol. 2007 Apr;64(4):576-80 [17420321] Br J Ophthalmol. 2003 Feb;87(2):128-30 [12543734] Neurol Sci. 2002 Sep;23 Suppl 2:S81-2 [12548354] Neurology. 2003 Jun 24;60(12):2017-8 [12821763] J Opt Soc Am A Opt Image Sci Vis. 2003 Oct;20(10):1852-8 [14570098] Am J Ophthalmol. 2003 Nov;136(5):846-52 [14597035] Clin Neurophysiol. 2004 Feb;115(2):341-7 [14744575] Ann Neurol. 2004 Oct;56(4):540-7 [15455404] Neurology. 2004 Oct 26;63(8):1423-6 [15505159] Cephalalgia. 1997 Nov;17(7):733-41 [9399002] Neurosurgery. 2005 Feb;56(2):E415; discussion E415 [15670394] Neuron. 2005 Feb 3;45(3):447-57 [15694330] Mov Disord. 2005 Mar;20(3):283-92 [15641011] Mov Disord. 2005 Sep;20(9):1203-5 [15954126] J Neurol Neurosurg Psychiatry. 2005 Nov;76(11):1591-3 [16227560] Brain. 2007 May;130(Pt 5):1183-93 [17242025] Ocul Surf. 2007 Apr;5(2):179-93 [17508121] Surv Ophthalmol. 2007 Jul-Aug;52(4):369-74 [17574063] J Neurol Neurosurg Psychiatry. 2007 Aug;78(8):877-9 [17578856] Mov Disord. 2007 Jun 15;22(8):1117-23 [17443700] J Neurol. 2007 Jul;254(7):890-6 [17325818] J Neurol. 2007 Jul;254(7):879-83 [17401742] Eur Neurol. 2007;58(3):138-41 [17622718] Mov Disord. 2007 Oct 15;22(13):1885-91 [17618522] Cereb Cortex. 2008 Apr;18(4):930-7 [17652462] J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):392-6 [17635969] Mov Disord. 2008 Mar 15;23(4):558-65 [18074393] Neurology. 2008 May 6;70(19):1699-706 [18458230] Mov Disord. 2005 Dec;20(12):1564-70 [16092106] Ophthalmology. 2005 Dec;112(12):2208-11 [16242188] Brain. 2006 Jan;129(Pt 1):36-46 [16280353] NeuroRx. 2005 Jul;2(3):513-24 [16389315] J Neurosci. 2006 Jan 11;26(2):716-21 [16407569] J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):252-4 [16421132] Trends Neurosci. 2006 Apr;29(4):192-9 [16519953] Eur J Ophthalmol. 2006 Mar-Apr;16(2):204-8 [16703535] Am J Ophthalmol. 2006 Jul;142(1):82-87 [16815254] Ann Neurol. 2000 Mar;47(3):377-80 [10716260] Brain. 2001 Jan;124(Pt 1):176-208 [11133797] J Neurosci. 2001 Jun 15;21(12):RC151 [11404443] Neurosci Lett. 2002 Jan 14;317(3):135-8 [11755258] J Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1017-20 [16690695] Mov Disord. 2006 Aug;21(8):1225-9 [16622858] Mov Disord. 2006 Aug;21(8):1175-81 [16673404] J Neural Transm Suppl. 2006;(70):485-8 [17017571] J Comp Neurol. 2007 Jan 1;500(1):134-65 [17099887] J Neurosurg. 2006 Nov;105(5):765-8 [17121141] Mov Disord. 2007 Jan 15;22(2):162-6 [17133500] J Neuroophthalmol. 2007 Mar;27(1):32-5 [17414870] Neurology. 2002 Nov 12;59(9):1306-12 [12434791] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1212/01.wnl.0000327601.46315.85 ER - TY - JOUR T1 - Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells AN - 19808591; 8759835 AB - Removal of TRF2, a telomere shelterin protein, recapitulates key aspects of telomere attrition including the DNA-damage response and cell-cycle arrest. Distinct from the response of proliferating cells to loss of TRF2, in rodent noncycling cells, TRF2 inhibition promotes differentiation and growth. However, the mechanism that couples telomere gene-silencing features to differentiation programs has yet to be elucidated. Here we describe an extratelomeric function of TRF2 in the regulation of neuronal genes mediated by the interaction of TRF2 with repressor element 1-silencing transcription factor (REST), a master repressor of gene networks devoted to neuronal functions. TRF2-REST complexes are readily detected by coimmunoprecipitation assays and are localized to aggregated PML-nuclear bodies in undifferentiated pluripotent human NTera2 stem cells. Inhibition of TRF2, either by a dominant-negative mutant or by RNA interference, dissociates TRF2-REST complexes resulting in ubiquitin-proteasomal degradation of REST. Consequentially, REST-targeted neural genes (L1CAM, b3-tubulin, synaptophysin, and others) are derepressed, resulting in acquisition of neuronal phenotypes. Notably, selective damage to telomeres without affecting TRF2 levels causes neither REST degradation nor cell differentiation. Thus, in addition to protecting telomeres, TRF2 possesses a novel role in stabilization of REST thereby controlling neural tumor and stem cell fate. JF - Current Biology AU - Zhang, P AU - Pazin, MJ AU - Schwartz, C M AU - Becker, K G AU - Wersto, R P AU - Dilley, C M AU - Mattson, M P AD - Laboratory of Neurosciences, Laboratory of Cellular and Molecular Biology, Research Resources Branch, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA, mattsonm@grc.nia.nih.gov Y1 - 2008/10/14/ PY - 2008 DA - 2008 Oct 14 SP - 1489 EP - 1494 VL - 18 IS - 19 SN - 0960-9822, 0960-9822 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - TRF2 protein KW - Transcription KW - Tumors KW - DNA damage KW - Differentiation KW - Telomeres KW - Synaptophysin KW - Stem cells KW - Gene regulation KW - Transcription factors KW - RNA-mediated interference KW - Telomere-binding protein KW - Repressors KW - Neural stem cells KW - Gene silencing KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19808591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Nontelomeric+TRF2-REST+Interaction+Modulates+Neuronal+Gene+Silencing+and+Fate+of+Tumor+and+Stem+Cells&rft.au=Zhang%2C+P%3BPazin%2C+MJ%3BSchwartz%2C+C+M%3BBecker%2C+K+G%3BWersto%2C+R+P%3BDilley%2C+C+M%3BMattson%2C+M+P&rft.aulast=Zhang&rft.aufirst=P&rft.date=2008-10-14&rft.volume=18&rft.issue=19&rft.spage=1489&rft.isbn=&rft.btitle=&rft.title=Current+Biology&rft.issn=09609822&rft_id=info:doi/10.1016%2Fj.cub.2008.08.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - TRF2 protein; Transcription; Tumors; Telomeres; Differentiation; DNA damage; Stem cells; Synaptophysin; Transcription factors; Gene regulation; RNA-mediated interference; Telomere-binding protein; Neural stem cells; Repressors; Gene silencing DO - http://dx.doi.org/10.1016/j.cub.2008.08.048 ER - TY - JOUR T1 - Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. AN - 69527843; 18640912 AB - Drugs and food exert their reinforcing effects in part by increasing dopamine (DA) in limbic regions, which has generated interest in understanding how drug abuse/addiction relates to obesity. Here, we integrate findings from positron emission tomography imaging studies on DA's role in drug abuse/addiction and in obesity and propose a common model for these two conditions. Both in abuse/addiction and in obesity, there is an enhanced value of one type of reinforcer (drugs and food, respectively) at the expense of other reinforcers, which is a consequence of conditioned learning and resetting of reward thresholds secondary to repeated stimulation by drugs (abuse/addiction) and by large quantities of palatable food (obesity) in vulnerable individuals (i.e. genetic factors). In this model, during exposure to the reinforcer or to conditioned cues, the expected reward (processed by memory circuits) overactivates the reward and motivation circuits while inhibiting the cognitive control circuit, resulting in an inability to inhibit the drive to consume the drug or food despite attempts to do so. These neuronal circuits, which are modulated by DA, interact with one another so that disruption in one circuit can be buffered by another, which highlights the need of multiprong approaches in the treatment of addiction and obesity. JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Telang, Frank AD - National Institute on Drug Abuse, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 SP - 3191 EP - 3200 VL - 363 IS - 1507 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Eating KW - Humans KW - Learning -- physiology KW - Conditioning (Psychology) -- physiology KW - Obesity -- pathology KW - Substance-Related Disorders -- pathology KW - Dopamine -- metabolism KW - Neural Pathways -- pathology KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69527843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.atitle=Overlapping+neuronal+circuits+in+addiction+and+obesity%3A+evidence+of+systems+pathology.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BTelang%2C+Frank&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2008-10-12&rft.volume=363&rft.issue=1507&rft.spage=3191&rft.isbn=&rft.btitle=&rft.title=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.issn=1471-2970&rft_id=info:doi/10.1098%2Frstb.2008.0107 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-17 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Psychiatry. 1999 Nov;156(11):1686-96 [10553730] Physiol Behav. 2007 Aug 15;91(5):486-98 [17307205] Cereb Cortex. 2000 Mar;10(3):318-25 [10731226] Diabetes. 2000 May;49(5):838-46 [10905495] Am J Psychiatry. 2000 Nov;157(11):1789-98 [11058476] Lancet. 2001 Feb 3;357(9253):354-7 [11210998] Exp Brain Res. 2001 Aug;139(3):278-86 [11545466] J Neurochem. 2001 Sep;78(5):1094-103 [11553683] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] Synapse. 2002 Jun 1;44(3):175-80 [11954049] Neuroimage. 2002 Jun;16(2):331-48 [12030820] Synapse. 2002 Nov;46(2):79-82 [12211085] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] Neuron. 2002 Oct 10;36(2):241-63 [12383780] Int J Eat Disord. 2003 Mar;33(2):136-42 [12616579] J Clin Invest. 2003 May;111(10):1444-51 [12750391] Am J Clin Nutr. 2003 Oct;78(4):834S-842S [14522747] J Neurosci. 2004 Feb 11;24(6):1265-71 [14960596] Neuroimage. 2004 Apr;21(4):1790-7 [15050599] Brain Cogn. 2004 Jun;55(1):11-29 [15134840] Mol Psychiatry. 2004 Jun;9(6):557-69 [15098002] Am J Psychiatry. 2004 Oct;161(10):1783-9 [15465974] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2088-92 [2006148] Am J Psychiatry. 1991 May;148(5):621-6 [2018164] Arch Gen Psychiatry. 1992 Sep;49(9):739-44 [1514879] Synapse. 1993 Jun;14(2):169-77 [8101394] Pharmacol Biochem Behav. 1994 Jul;48(3):651-60 [7938118] Brain Res. 1994 Aug 1;652(2):225-34 [7953734] Nature. 1997 Apr 24;386(6627):830-3 [9126741] Am J Psychiatry. 1999 Jan;156(1):19-26 [9892293] Life Sci. 1999;64(9):775-84 [10075110] Am J Psychiatry. 1999 Sep;156(9):1440-3 [10484959] Nat Rev Neurosci. 2004 Dec;5(12):963-70 [15550951] Neuron. 2005 Mar 3;45(5):647-50 [15748840] J Neurosci. 2005 Apr 13;25(15):3932-9 [15829645] Nat Neurosci. 2005 May;8(5):555-60 [15856062] Arch Neurol. 2007 Nov;64(11):1575-9 [17998440] J Neurosci. 2007 Nov 14;27(46):12700-6 [18003850] Neurosci Biobehav Rev. 2008;32(1):20-39 [17617461] Neuroimage. 2008 Oct 1;42(4):1537-43 [18598772] Nature. 1996 Feb 15;379(6566):606-12 [8628395] Pharmacol Biochem Behav. 1996 Jan;53(1):221-6 [8848454] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12040-5 [8876259] Biol Psychiatry. 2005 Nov 15;58(10):779-86 [16018986] Eur J Pharmacol. 2005 Dec 5;526(1-3):77-88 [16310768] J Neurosci. 2006 Jun 14;26(24):6583-8 [16775146] Arch Gen Psychiatry. 2006 Sep;63(9):999-1008 [16953002] Neuropsychopharmacology. 2006 Dec;31(12):2716-27 [16971900] Obes Rev. 2007 Mar;8 Suppl 1:73-5 [17316306] Am J Psychiatry. 2007 Apr;164(4):622-9 [17403976] Am J Psychiatry. 2007 May;164(5):708-10 [17475727] J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):615-9 [17158560] Synapse. 2007 Sep;61(9):748-56 [17568412] Cereb Cortex. 2000 Mar;10(3):284-94 [10731223] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1098/rstb.2008.0107 ER - TY - CPAPER T1 - Applications of Microfabricated and Nanofabricated Systems toward Cancer Diagnosis T2 - 2008 Fall Meeting of the Electrochemical Society of Japan and 214th Meeting of the Electrochemical Society (PRiME 2008) AN - 42096261; 4986823 JF - 2008 Fall Meeting of the Electrochemical Society of Japan and 214th Meeting of the Electrochemical Society (PRiME 2008) AU - Nagahara, Larry A Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42096261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Fall+Meeting+of+the+Electrochemical+Society+of+Japan+and+214th+Meeting+of+the+Electrochemical+Society+%28PRiME+2008%29&rft.atitle=Applications+of+Microfabricated+and+Nanofabricated+Systems+toward+Cancer+Diagnosis&rft.au=Nagahara%2C+Larry+A&rft.aulast=Nagahara&rft.aufirst=Larry&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Fall+Meeting+of+the+Electrochemical+Society+of+Japan+and+214th+Meeting+of+the+Electrochemical+Society+%28PRiME+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.electrochem.org/meetings/biannual/214/mas_802/reportSymposi umList.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of IFN-alpha-induced Genes and Proteins that are Associated with Antiviral Activity in DAUDI Cells. T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42086864; 4975879 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Schmeisser, Hana AU - Mejido, Josef AU - Zoon, Kathryn C Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Antiviral agents KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42086864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Identification+of+IFN-alpha-induced+Genes+and+Proteins+that+are+Associated+with+Antiviral+Activity+in+DAUDI+Cells.&rft.au=Schmeisser%2C+Hana%3BMejido%2C+Josef%3BZoon%2C+Kathryn+C&rft.aulast=Schmeisser&rft.aufirst=Hana&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Control of Immune Responses by Natural and Adaptive Regulatory T-cells T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42073977; 4976160 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Shevach, Ethan M AU - Huter, Eva AU - Tran, Dat AU - Andersson, John Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42073977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Control+of+Immune+Responses+by+Natural+and+Adaptive+Regulatory+T-cells&rft.au=Shevach%2C+Ethan+M%3BHuter%2C+Eva%3BTran%2C+Dat%3BAndersson%2C+John&rft.aulast=Shevach&rft.aufirst=Ethan&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV Infection Leads to Increased Proliferation of T-cells by Two Distinct Pathways that Differentially Affect CD4 and CD8 T-cells T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42073407; 4976213 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Catalfamo, Marta AU - Wilhelm, Christopher AU - Di Mascio, Michele AU - Hu, Zonghui AU - Srinivasula, Sharat AU - Thaker, Vishakha AU - Adelsberger, Joseph AU - Rupert, Adam AU - Baseler, Michael AU - Tagaya, Yutaka AU - Roby, Gregg AU - Rehm, Catherine AU - Follmann, Dean AU - Lane, Clifford Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Human immunodeficiency virus KW - Infection KW - Lymphocytes T KW - CD8 antigen KW - CD4 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42073407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=HIV+Infection+Leads+to+Increased+Proliferation+of+T-cells+by+Two+Distinct+Pathways+that+Differentially+Affect+CD4+and+CD8+T-cells&rft.au=Catalfamo%2C+Marta%3BWilhelm%2C+Christopher%3BDi+Mascio%2C+Michele%3BHu%2C+Zonghui%3BSrinivasula%2C+Sharat%3BThaker%2C+Vishakha%3BAdelsberger%2C+Joseph%3BRupert%2C+Adam%3BBaseler%2C+Michael%3BTagaya%2C+Yutaka%3BRoby%2C+Gregg%3BRehm%2C+Catherine%3BFollmann%2C+Dean%3BLane%2C+Clifford&rft.aulast=Catalfamo&rft.aufirst=Marta&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine Responses of NaA=ve T-cells Requires Special Permission by Accessory Cells T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42071929; 4975973 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Sato, Noriko AU - Waldmann, Thomas A AU - Tagaya, Yutaka Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Cytokines KW - Lymphocytes T KW - Accessory cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42071929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Cytokine+Responses+of+NaA%3Dve+T-cells+Requires+Special+Permission+by+Accessory+Cells&rft.au=Sato%2C+Noriko%3BWaldmann%2C+Thomas+A%3BTagaya%2C+Yutaka&rft.aulast=Sato&rft.aufirst=Noriko&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Innate Immunity: Preclinical Study of Eradication of Tumor Cells by IFN-activated Monocytes in vitro and in vivo. T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42071766; 4976212 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Baron, Samuel AU - Poast, Joyce AU - Suzuki, Fujio AU - Kobayashi, Makiko AU - Clouse, Kathleen AU - Bacot, Sylvia AU - Tiffany, Linda AU - Lankford, Carla AU - Boekhoudt, Gunther AU - Morrow, Angel AU - Fey, Samuel AU - Schmeisser, Hana AU - Bekisz, Joseph AU - Zoon, Kathryn Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Tumors KW - Tumor cells KW - Immunity KW - Monocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42071766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Innate+Immunity%3A+Preclinical+Study+of+Eradication+of+Tumor+Cells+by+IFN-activated+Monocytes+in+vitro+and+in+vivo.&rft.au=Baron%2C+Samuel%3BPoast%2C+Joyce%3BSuzuki%2C+Fujio%3BKobayashi%2C+Makiko%3BClouse%2C+Kathleen%3BBacot%2C+Sylvia%3BTiffany%2C+Linda%3BLankford%2C+Carla%3BBoekhoudt%2C+Gunther%3BMorrow%2C+Angel%3BFey%2C+Samuel%3BSchmeisser%2C+Hana%3BBekisz%2C+Joseph%3BZoon%2C+Kathryn&rft.aulast=Baron&rft.aufirst=Samuel&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutations in the Interleukin-1 Receptor Antagonist Cause a New Autoinflammatory Disease T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42071755; 4975840 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Aksentijevich, Ivona AU - Ferguson, Polly J AU - Booty, Matthew G AU - Laurence, Arian AU - Pham, Hang AU - Stone, Deborah L AU - Cowen, Edward W AU - Plass, Nicole AU - Bing, Xinyu AU - Clarke, Gillian I AU - El-Shanti, Hatem I AU - Royen, Annet van AU - Frenk, Joost AU - Remmers, Elaine F AU - Dancey, Paul AU - Kastner, Daniel L AU - Rahman, Proton AU - Ohson, Kamal Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Mutation KW - Interleukin 1 receptor antagonist KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42071755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Mutations+in+the+Interleukin-1+Receptor+Antagonist+Cause+a+New+Autoinflammatory+Disease&rft.au=Aksentijevich%2C+Ivona%3BFerguson%2C+Polly+J%3BBooty%2C+Matthew+G%3BLaurence%2C+Arian%3BPham%2C+Hang%3BStone%2C+Deborah+L%3BCowen%2C+Edward+W%3BPlass%2C+Nicole%3BBing%2C+Xinyu%3BClarke%2C+Gillian+I%3BEl-Shanti%2C+Hatem+I%3BRoyen%2C+Annet+van%3BFrenk%2C+Joost%3BRemmers%2C+Elaine+F%3BDancey%2C+Paul%3BKastner%2C+Daniel+L%3BRahman%2C+Proton%3BOhson%2C+Kamal&rft.aulast=Aksentijevich&rft.aufirst=Ivona&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene and Protein Expression Observed After Treatment of DAUDI Cells with IFN-?2c and IFN-?21? T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42070361; 4975877 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Bekisz, Joseph AU - Mejido, Josef AU - Veenstra, Timothy AU - Zoon, Kathryn Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42070361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Gene+and+Protein+Expression+Observed+After+Treatment+of+DAUDI+Cells+with+IFN-%3F2c+and+IFN-%3F21%3F&rft.au=Bekisz%2C+Joseph%3BMejido%2C+Josef%3BVeenstra%2C+Timothy%3BZoon%2C+Kathryn&rft.aulast=Bekisz&rft.aufirst=Joseph&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of TOLL/IL-1 Receptor Domain Dimerization and Signaling Revealed by the Crystal Structure of MYD88 T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42070206; 4976014 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Snyder, Greg A AU - Jiang, Jiansheng AU - Xiao, Tsan Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Signal transduction KW - Interleukin 1 receptors KW - MyD88 protein KW - Crystal structure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42070206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Mechanism+of+TOLL%2FIL-1+Receptor+Domain+Dimerization+and+Signaling+Revealed+by+the+Crystal+Structure+of+MYD88&rft.au=Snyder%2C+Greg+A%3BJiang%2C+Jiansheng%3BXiao%2C+Tsan&rft.aulast=Snyder&rft.aufirst=Greg&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mechanism of Interferon Gene Transcription in Dendritic Cells T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42070041; 4975996 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Ozato, Keiko AU - Tailor, Prafullakumar AU - Ramakrishna, Lakshimi AU - Chang, Tsung Hsien AU - Kubota, Toru AU - Matsuoka, Mayumi AU - Morse, Herbert Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Interferon KW - Dendritic cells KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42070041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=The+Mechanism+of+Interferon+Gene+Transcription+in+Dendritic+Cells&rft.au=Ozato%2C+Keiko%3BTailor%2C+Prafullakumar%3BRamakrishna%2C+Lakshimi%3BChang%2C+Tsung+Hsien%3BKubota%2C+Toru%3BMatsuoka%2C+Mayumi%3BMorse%2C+Herbert&rft.aulast=Ozato&rft.aufirst=Keiko&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine Signaling and T-cell Differentiation T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42068456; 4976037 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - O'Shea, John Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Signal transduction KW - Cytokines KW - Differentiation KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42068456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Cytokine+Signaling+and+T-cell+Differentiation&rft.au=O%27Shea%2C+John&rft.aulast=O%27Shea&rft.aufirst=John&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Up-regulation of Cytokine Encoding Genes by CpG Oligonucleotides Plus Poly (I:C). T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42068104; 4976069 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Petrenko, Lev AU - Klaschik, Sven AU - Shirota, Hidekazu AU - Klinman, Dennis M Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Cytokines KW - Oligonucleotides KW - Poly (I:C) KW - CpG islands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42068104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Synergistic+Up-regulation+of+Cytokine+Encoding+Genes+by+CpG+Oligonucleotides+Plus+Poly+%28I%3AC%29.&rft.au=Petrenko%2C+Lev%3BKlaschik%2C+Sven%3BShirota%2C+Hidekazu%3BKlinman%2C+Dennis+M&rft.aulast=Petrenko&rft.aufirst=Lev&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Immunomodulatory CD300A Receptor is Differentially Expressed on Human TH1 AND TH17 Cells T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42067213; 4976045 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Borrego, Francisco AU - Narayanan, Sriram AU - Tang, Xiaobin AU - Alvarez, Yelina AU - Coligan, John E Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Helper cells KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42067213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=The+Immunomodulatory+CD300A+Receptor+is+Differentially+Expressed+on+Human+TH1+AND+TH17+Cells&rft.au=Borrego%2C+Francisco%3BNarayanan%2C+Sriram%3BTang%2C+Xiaobin%3BAlvarez%2C+Yelina%3BColigan%2C+John+E&rft.aulast=Borrego&rft.aufirst=Francisco&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Innate Immune Antiviral Mechanism of Action of Ribavirin in Mammalian Cells Contributes to Efficacy of Combination Therapy for Hepatitis C T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42066898; 4976253 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Thomas, Emmanuel AU - Hu, Zongyi AU - Dong, Stephen AU - Feld, Jordan J AU - Liang, T Jake Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Hepatitis C KW - Antiviral activity KW - Ribavirin KW - Mammalian cells KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42066898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=A+Novel+Innate+Immune+Antiviral+Mechanism+of+Action+of+Ribavirin+in+Mammalian+Cells+Contributes+to+Efficacy+of+Combination+Therapy+for+Hepatitis+C&rft.au=Thomas%2C+Emmanuel%3BHu%2C+Zongyi%3BDong%2C+Stephen%3BFeld%2C+Jordan+J%3BLiang%2C+T+Jake&rft.aulast=Thomas&rft.aufirst=Emmanuel&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inductive and Suppressive Networks Regulate TLR9-dependent Gene Expression in vivo T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42065242; 4976067 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Klaschik, Sven AU - Tross, Debra AU - Klinman, Dennis M Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42065242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Inductive+and+Suppressive+Networks+Regulate+TLR9-dependent+Gene+Expression+in+vivo&rft.au=Klaschik%2C+Sven%3BTross%2C+Debra%3BKlinman%2C+Dennis+M&rft.aulast=Klaschik&rft.aufirst=Sven&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell Generation and Resistance to TNBSColitis Induction T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42065207; 4976049 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Boirivant, Monica AU - Amendola, Antonello AU - Butera, Alessia AU - Sanchez, Massimo AU - Xu, Lili AU - Marinaro, Mariarosaria AU - Kitani, Atsushi AU - Di Giacinto, Claudia AU - Strober, Warren AU - Fuss, Ivan J Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Lymphocytes T KW - Barriers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42065207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=A+Transient+Breach+in+the+Epithelial+Barrier+Leads+to+Regulatory+T-Cell+Generation+and+Resistance+to+TNBSColitis+Induction&rft.au=Boirivant%2C+Monica%3BAmendola%2C+Antonello%3BButera%2C+Alessia%3BSanchez%2C+Massimo%3BXu%2C+Lili%3BMarinaro%2C+Mariarosaria%3BKitani%2C+Atsushi%3BDi+Giacinto%2C+Claudia%3BStrober%2C+Warren%3BFuss%2C+Ivan+J&rft.aulast=Boirivant&rft.aufirst=Monica&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of miRNAs in the Regulation of Interferon-gamma Gene Expression T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42065099; 4976032 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Savan, Ram AU - Yalamanchili, Rajesh AU - Hakim, Shakeeb AU - Young, Howard A Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Gene expression KW - MiRNA KW - G-Interferon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42065099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=The+Role+of+miRNAs+in+the+Regulation+of+Interferon-gamma+Gene+Expression&rft.au=Savan%2C+Ram%3BYalamanchili%2C+Rajesh%3BHakim%2C+Shakeeb%3BYoung%2C+Howard+A&rft.aulast=Savan&rft.aufirst=Ram&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development and Maintenance of T-cells Require Post-Translational Regulation of Anti-apoptotic MCL-1 and Pro-apoptotic BIM by IL-7. T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42064845; 4976125 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Li, Wenqing AU - Guszczynski, Tad AU - Hixon, Julie AU - Durum, Scott K Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Lymphocytes T KW - Interleukin 7 KW - Post-translation KW - Mcl-1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42064845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Development+and+Maintenance+of+T-cells+Require+Post-Translational+Regulation+of+Anti-apoptotic+MCL-1+and+Pro-apoptotic+BIM+by+IL-7.&rft.au=Li%2C+Wenqing%3BGuszczynski%2C+Tad%3BHixon%2C+Julie%3BDurum%2C+Scott+K&rft.aulast=Li&rft.aufirst=Wenqing&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-27 is a Novel Anti-viral Cytokine that Inhibits Replication of HIV-1 and HCV T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42064349; 4976144 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Brann, Terrence W AU - Yang, Jun AU - Huang, Da-Wei AU - Frank, Astrid AU - Lempicki, Richard A AU - Baseler, Michael W AU - Kottilili, Shaym AU - Lane, H Clifford AU - Imamichi, Tom Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Replication KW - Antiviral agents KW - Interleukin 27 KW - Hepatitis C virus KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42064349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=IL-27+is+a+Novel+Anti-viral+Cytokine+that+Inhibits+Replication+of+HIV-1+and+HCV&rft.au=Brann%2C+Terrence+W%3BYang%2C+Jun%3BHuang%2C+Da-Wei%3BFrank%2C+Astrid%3BLempicki%2C+Richard+A%3BBaseler%2C+Michael+W%3BKottilili%2C+Shaym%3BLane%2C+H+Clifford%3BImamichi%2C+Tom&rft.aulast=Brann&rft.aufirst=Terrence&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Receptor and Cell-specific Function of MAP3K8/TPL2 in Innate Immune Signaling and Cytokine Production T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42064310; 4976140 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Mielke, Lisa A AU - Elkins, Karen AU - Starr, Robyn AU - Hilton, Douglas J AU - Tsichlis, Philip AU - O'Shea, John J AU - Watford, Wendy T Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Signal transduction KW - Cytokines KW - Receptor mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42064310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Receptor+and+Cell-specific+Function+of+MAP3K8%2FTPL2+in+Innate+Immune+Signaling+and+Cytokine+Production&rft.au=Mielke%2C+Lisa+A%3BElkins%2C+Karen%3BStarr%2C+Robyn%3BHilton%2C+Douglas+J%3BTsichlis%2C+Philip%3BO%27Shea%2C+John+J%3BWatford%2C+Wendy+T&rft.aulast=Mielke&rft.aufirst=Lisa&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signaling and Gene Regulation by ?c-Dependent Cytokines T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42063762; 4976156 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Leonard, Warren Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Signal transduction KW - Cytokines KW - Gene regulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42063762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Signaling+and+Gene+Regulation+by+%3Fc-Dependent+Cytokines&rft.au=Leonard%2C+Warren&rft.aulast=Leonard&rft.aufirst=Warren&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IFN-gamma 3'untranslated Region AU-RICH Element-deleted Mice have Altered Immune Structure and Function. T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42063684; 4976137 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Hodge, Deborah L AU - Berthet, Cyril AU - Subleski, Jeff AU - Bere, William AU - Chen, Xin AU - Coppola, Vincenzo AU - Buschman, Matthew AU - Wolfe, Thomas AU - Shuggi, Isabelle AU - Young, Howard A Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Mice KW - Structure-function relationships KW - G-Interferon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42063684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=IFN-gamma+3%27untranslated+Region+AU-RICH+Element-deleted+Mice+have+Altered+Immune+Structure+and+Function.&rft.au=Hodge%2C+Deborah+L%3BBerthet%2C+Cyril%3BSubleski%2C+Jeff%3BBere%2C+William%3BChen%2C+Xin%3BCoppola%2C+Vincenzo%3BBuschman%2C+Matthew%3BWolfe%2C+Thomas%3BShuggi%2C+Isabelle%3BYoung%2C+Howard+A&rft.aulast=Hodge&rft.aufirst=Deborah&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokines in Guillain Barre Syndrome T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42063343; 4975893 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Patil, Shripad A AU - Taly, Arun B Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Cytokines KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42063343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Cytokines+in+Guillain+Barre+Syndrome&rft.au=Patil%2C+Shripad+A%3BTaly%2C+Arun+B&rft.aulast=Patil&rft.aufirst=Shripad&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of ISGF3 in Response to Interferon Gamma in Human Cells T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42063232; 4975880 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Morrow, Angel N AU - Schmeisser, Hana AU - Tsuno, Takaya AU - Zoon, Kathryn C Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - G-Interferon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42063232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Induction+of+ISGF3+in+Response+to+Interferon+Gamma+in+Human+Cells&rft.au=Morrow%2C+Angel+N%3BSchmeisser%2C+Hana%3BTsuno%2C+Takaya%3BZoon%2C+Kathryn+C&rft.aulast=Morrow&rft.aufirst=Angel&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Roles of JAK-STAT Pathway Factors in Antiproliferative Activities of Human IFN-? and IFN-?: A Comprehensive Assessment in Human Ovarian Adenocarcinoma OVCAR3 Cells T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42062611; 4975831 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Tsuno, Takaya AU - Mejido, Josef AU - Zhao, Tongmao AU - Morrow, Angel AU - Zoon, Kathryn C Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - A-Interferon KW - Interferon KW - Adenocarcinoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42062611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Roles+of+JAK-STAT+Pathway+Factors+in+Antiproliferative+Activities+of+Human+IFN-%3F+and+IFN-%3F%3A+A+Comprehensive+Assessment+in+Human+Ovarian+Adenocarcinoma+OVCAR3+Cells&rft.au=Tsuno%2C+Takaya%3BMejido%2C+Josef%3BZhao%2C+Tongmao%3BMorrow%2C+Angel%3BZoon%2C+Kathryn+C&rft.aulast=Tsuno&rft.aufirst=Takaya&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokines Control CD4+ CD25+ Foxp3+ Regulatory T-cell Survival and their Mechanism of Suppression T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42062179; 4975855 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Pandiyan, Pushpa AU - Lenardo, Michael Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Survival KW - Cytokines KW - Lymphocytes T KW - Foxp3 protein KW - CD25 antigen KW - CD4 antigen KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42062179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Cytokines+Control+CD4%2B+CD25%2B+Foxp3%2B+Regulatory+T-cell+Survival+and+their+Mechanism+of+Suppression&rft.au=Pandiyan%2C+Pushpa%3BLenardo%2C+Michael&rft.aulast=Pandiyan&rft.aufirst=Pushpa&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TL1A-DR3 Interactions Drive Immunopathology Mediated by Multiple T-cell Subsets T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42062141; 4975839 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Siegel, Richard M AU - Kahle, Erin AU - Acharya, Krishika AU - Fuss, Ivan AU - Wang, Eddie AU - Meylan, Francoise Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42062141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=TL1A-DR3+Interactions+Drive+Immunopathology+Mediated+by+Multiple+T-cell+Subsets&rft.au=Siegel%2C+Richard+M%3BKahle%2C+Erin%3BAcharya%2C+Krishika%3BFuss%2C+Ivan%3BWang%2C+Eddie%3BMeylan%2C+Francoise&rft.aulast=Siegel&rft.aufirst=Richard&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Pro-Inflammatory Cytokines in Carcinogenesis T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42062057; 4975819 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Trinchieri, Giorgio Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Carcinogenesis KW - Cytokines KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42062057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Role+of+Pro-Inflammatory+Cytokines+in+Carcinogenesis&rft.au=Trinchieri%2C+Giorgio&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ebola and Marburg Viruses: Immunopathology and Immunoprotection T2 - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AN - 42061870; 4976119 JF - 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (Cytokines 2008) AU - Feldmann, Heinz Y1 - 2008/10/12/ PY - 2008 DA - 2008 Oct 12 KW - Viruses KW - Marburg virus KW - Ebola virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42061870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.atitle=Ebola+and+Marburg+Viruses%3A+Immunopathology+and+Immunoprotection&rft.au=Feldmann%2C+Heinz&rft.aulast=Feldmann&rft.aufirst=Heinz&rft.date=2008-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Joint+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research+and+the+International+Cytokine+Society+%28Cytokines+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://cytokines2008.org/pdf/ScientificProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats. AN - 69497311; 18682277 AB - Neurochemical studies suggest that baclofen, an agonist at GABA(B) receptors, may be useful for treatment of nicotine dependence. However, its ability to selectively reduce nicotine's abuse-related behavioral effects remains in question. We assessed effects of baclofen doses ranging from 0.1 to 3mg/kg on nicotine-induced conditioned place preferences (CPPs), nicotine discrimination, locomotor activity and food-reinforced behavior in male Sprague-Dawley rats. The high dose of baclofen (3mg/kg) totally eliminated food-reinforced responding and significantly decreased locomotor activity. Lower doses of baclofen did not have nicotine-like discriminative effects in rats trained to discriminate 0.4mg/kg nicotine from saline under a fixed-ratio 10 schedule of food delivery. Lower doses of baclofen also did not reduce discriminative stimulus effects of the training dose of nicotine and did not significantly shift the dose-response curve for nicotine discrimination. Rats treated with the high 3mg/kg dose of baclofen did not express nicotine-induced CPP. These experiments, along with previous reports that baclofen can reduce intravenous nicotine self-administration behavior, confirm the potential utility of baclofen as a tool for smoking cessation. JF - Neuroscience letters AU - Le Foll, Bernard AU - Wertheim, Carrie E AU - Goldberg, Steven R AD - National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA. bernard_lefoll@camh.net Y1 - 2008/10/10/ PY - 2008 DA - 2008 Oct 10 SP - 236 EP - 240 VL - 443 IS - 3 SN - 0304-3940, 0304-3940 KW - GABA Agonists KW - 0 KW - Nicotinic Agonists KW - Nicotine KW - 6M3C89ZY6R KW - Baclofen KW - H789N3FKE8 KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Reinforcement Schedule KW - Dose-Response Relationship, Drug KW - Motor Activity -- drug effects KW - Male KW - Conditioning, Operant -- drug effects KW - Discrimination (Psychology) -- drug effects KW - GABA Agonists -- pharmacology KW - Reward KW - Discrimination (Psychology) -- physiology KW - Conditioning, Operant -- physiology KW - Nicotine -- pharmacology KW - Nicotinic Agonists -- pharmacology KW - Baclofen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69497311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Effects+of+baclofen+on+conditioned+rewarding+and+discriminative+stimulus+effects+of+nicotine+in+rats.&rft.au=Le+Foll%2C+Bernard%3BWertheim%2C+Carrie+E%3BGoldberg%2C+Steven+R&rft.aulast=Le+Foll&rft.aufirst=Bernard&rft.date=2008-10-10&rft.volume=443&rft.issue=3&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2008.07.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-03 N1 - Date created - 2008-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 2003 Jun;167(4):335-43 [12684733] Neuroscience. 2003;118(1):123-34 [12676144] Psychopharmacology (Berl). 2004 Mar;172(2):179-86 [14610636] Neuroreport. 2004 Sep 15;15(13):2139-43 [15486497] J Neurochem. 1977 Nov;29(5):797-802 [591956] J Consult Clin Psychol. 1982 Feb;50(1):71-86 [7056922] Psychopharmacology (Berl). 1983;81(1):54-60 [6415731] Psychopharmacology (Berl). 1984;84(3):413-9 [6440189] Pharmacol Biochem Behav. 1985 Feb;22(2):237-41 [2858867] Br J Pharmacol. 1987 Jan;90(1):239-46 [2880625] Eur J Pharmacol. 1986 Dec 16;132(2-3):337-8 [3816984] Trends Pharmacol Sci. 1992 May;13(5):177-84 [1604710] Pharmacol Biochem Behav. 1994 Jul;48(3):817-20 [7938142] Nature. 1996 Jul 18;382(6588):255-7 [8717040] Neuropsychopharmacology. 1996 Oct;15(4):417-23 [8887996] BMJ. 1997 Jan 18;314(7075):180-1 [9022432] Psychopharmacology (Berl). 1997 Feb;129(4):390-7 [9085409] Psychopharmacology (Berl). 1997 Jun;131(3):271-7 [9203238] Nature. 1997 Nov 27;390(6658):401-4 [9389479] Behav Pharmacol. 1998 May;9(3):195-206 [9832934] Synapse. 1999 Jan;31(1):76-86 [10025686] J Pharmacol Exp Ther. 1999 Mar;288(3):1053-73 [10027843] Psychopharmacology (Berl). 1999 Apr;143(2):209-14 [10326784] J Pharmacol Exp Ther. 1999 Sep;290(3):1369-74 [10454516] Ann N Y Acad Sci. 2004 Oct;1025:491-503 [15542754] Neuropsychopharmacology. 2005 Jan;30(1):119-28 [15266350] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Psychopharmacology (Berl). 2005 Apr;178(4):481-92 [15765262] Neuropsychopharmacology. 2005 Apr;30(4):720-30 [15562293] Psychopharmacology (Berl). 2006 Mar;184(3-4):367-81 [16205918] Lancet. 2007 Dec 8;370(9603):1915-22 [18068515] Addict Biol. 2008 Jun;13(2):239-52 [18482433] Life Sci. 2000 Feb 18;66(13):PL169-73 [10737423] Psychopharmacology (Berl). 2000 Feb;148(3):314-21 [10755745] Nicotine Tob Res. 2001 May;3(2):123-9 [11403726] Pharmacol Biochem Behav. 2001 Dec;70(4):515-30 [11796151] Drug Alcohol Depend. 2002 Feb 1;65(3):209-20 [11841892] Synapse. 2002 May;44(2):61-3 [11891877] Neuropharmacology. 2002 Mar;42(4):530-9 [11955523] Life Sci. 2001 Dec 7;70(3):349-56 [12005267] Synapse. 2002 Jun 15;44(4):252-3 [11984860] Alcohol Alcohol. 2002 Sep-Oct;37(5):478-84 [12217943] Alcohol Alcohol. 2002 Sep-Oct;37(5):495-8 [12217945] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] Mol Psychiatry. 2003 Feb;8(2):225-30 [12610655] Neuropsychopharmacology. 2003 Mar;28(3):510-8 [12629530] Synapse. 2003 Oct;50(1):1-6 [12872287] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2008.07.074 ER - TY - JOUR T1 - The mitochondrial antiviral signaling protein, MAVS, is cleaved during apoptosis AN - 19896933; 8493757 AB - Apoptosis of virus-infected cells is one important host strategy used to limit viral infection. Recently a member of the innate immune signaling pathway, MAVS, was localized to mitochondria, an organelle important for apoptosis regulation. Here we investigate what role MAVS may play in apoptosis. Induction of cell death led to the rapid cleavage of MAVS, resulting in its release from the outer mitochondrial membrane. This cleavage is blocked in cells incubated with proteasome or caspase inhibitors. Transfection of synthetic viral dsRNA and dsDNA also led to cleavage of MAVS, indicating that this process may be important during infection. Preventing apoptosis by over-expression of anti-apoptotic Bcl-xL blocks MAVS cleavage, placing this process downstream of caspase activation in the apoptotic program. JF - Biochemical and Biophysical Research Communications AU - Scott, I AU - Norris, K L AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2C-1014, Building 35, 9000 Rockville Pike, Bethesda, MD 20892, USA, scotti@ninds.nih.gov Y1 - 2008/10/10/ PY - 2008 DA - 2008 Oct 10 SP - 101 EP - 106 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 375 IS - 1 SN - 0006-291X, 0006-291X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - Apoptosis KW - Double-stranded RNA KW - Caspase inhibitors KW - proteasomes KW - Mitochondria KW - Infection KW - Bcl-x protein KW - Transfection KW - Overexpression KW - Caspase KW - Organelles KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19896933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=The+mitochondrial+antiviral+signaling+protein%2C+MAVS%2C+is+cleaved+during+apoptosis&rft.au=Scott%2C+I%3BNorris%2C+K+L&rft.aulast=Scott&rft.aufirst=I&rft.date=2008-10-10&rft.volume=375&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2008.07.147 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bcl-x protein; Apoptosis; Transfection; Double-stranded RNA; Overexpression; Caspase inhibitors; proteasomes; Mitochondria; Caspase; Organelles; Infection; Signal transduction DO - http://dx.doi.org/10.1016/j.bbrc.2008.07.147 ER - TY - JOUR T1 - Construction of a Large Phage-Displayed Human Antibody Domain Library with a Scaffold Based On a Newly Identified Highly Soluble, Stable Heavy Chain Variable Domain AN - 19804496; 8559409 AB - Currently, almost all U.S. Food and Drug Administration-approved therapeutic antibodies and the vast majority of those in clinical trials are full-size antibodies mostly in an immunoglobulin G1 format of about 150 kDa in size. Two fundamental problems for such large molecules are their poor penetration into tissues (e.g., solid tumors) and poor or absent binding to regions on the surface of some molecules [e.g., on the human immunodeficiency virus envelope glycoprotein (Env)] that are accessible by molecules of smaller size. We have identified a phage-displayed heavy chain-only antibody by panning of a large (size, arrow right .5x10 super(1) super(0)) human naive Fab (antigen-binding fragment) library against an Env and found that the heavy chain variable domain (V sub(H)) of this antibody, designated as m0, was independently folded, stable, highly soluble, monomeric, and expressed at high levels in bacteria. m0 was used as a scaffold to construct a large (size, arrow up .5x10 super(1) super(0)), highly diversified phage-displayed human V sub(H) library by grafting naturally occurring complementarity-determining regions (CDRs) 2 and 3 of heavy chains from five human antibody Fab libraries and by randomly mutating four putative solvent-accessible residues in CDR1 to A, D, S, or Y. The sequence diversity of all CDRs was determined from 143 randomly selected clones. Most of these V sub(H)s were with different CDR2 origins (six of seven groups of V sub(H) germlines) or CDR3 lengths (ranging from 7 to 24 residues) and could be purified directly from the soluble fraction of the Escherichia coli periplasm. The quality of the library was also validated by successful selection of high-affinity V sub(H)s against viral and cancer-related antigens; all selected V sub(H)s were monomeric, easily expressed, and purified with high solubility and yield. This library could be a valuable source of antibodies targeting size-restricted epitopes and antigens in obstructed locations where efficient penetration could be critical for successful treatment. JF - Journal of Molecular Biology AU - Chen, W AU - Zhu, Z AU - Feng, Y AU - Xiao, X AU - Dimitrov, D S AD - Center for Cancer Research Nanobiology Program, National Cancer Institute (NCI)-Frederick, National Institutes of Health (NIH), Frederick, MD 21702-1201, USA, dimitrov@ncifcrf.gov Y1 - 2008/10/10/ PY - 2008 DA - 2008 Oct 10 SP - 779 EP - 789 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 382 IS - 3 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - complementarity-determining region 3 KW - Solubility KW - Grafting KW - Solid tumors KW - Food KW - complementarity-determining region 1 KW - Panning KW - Clinical trials KW - scaffolds KW - Antibodies KW - Envelopes KW - Human immunodeficiency virus KW - Escherichia coli KW - Immunoglobulin G KW - Glycoproteins KW - Fab KW - Drugs KW - periplasm KW - Epitopes KW - V 22360:AIDS and HIV KW - K 03330:Biochemistry KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19804496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Construction+of+a+Large+Phage-Displayed+Human+Antibody+Domain+Library+with+a+Scaffold+Based+On+a+Newly+Identified+Highly+Soluble%2C+Stable+Heavy+Chain+Variable+Domain&rft.au=Chen%2C+W%3BZhu%2C+Z%3BFeng%2C+Y%3BXiao%2C+X%3BDimitrov%2C+D+S&rft.aulast=Chen&rft.aufirst=W&rft.date=2008-10-10&rft.volume=382&rft.issue=3&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2008.07.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - complementarity-determining region 3; Solubility; Grafting; Solid tumors; complementarity-determining region 1; Food; Panning; Clinical trials; scaffolds; Antibodies; Envelopes; Immunoglobulin G; Glycoproteins; Fab; periplasm; Drugs; Epitopes; Human immunodeficiency virus; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2008.07.054 ER - TY - JOUR T1 - Nutrition and cancer: essential elements for a roadmap. AN - 69543769; 18599198 AB - Personalizing nutrition for cancer prevention and therapy will require a comprehensive understanding of "genotypes/phenotypes" in order to identify, evaluate, and prioritize appropriate points for dietary intervention. This nutritional preemption roadmap must begin with accurately assessing intakes/exposures of which bioactive food component(s) is needed to bring about a desired response in critical cellular processes (carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetic) within an individual. Understanding this "individuality" through a better understanding of the "omics" is fundamental to arriving at the correct destination and thus interpreting biological variables which establish the magnitude or direction of a response to bioactive food components. JF - Cancer letters AU - Milner, J A AD - Nutritional Sciences Research Group, Division Cancer Prevention, NCI/NIH/HHS, 6130 Executive Boulevard, Executive Plaza North, Suite 3164, Rockville, MD 20852, USA. milnerj@mail.nih.gov Y1 - 2008/10/08/ PY - 2008 DA - 2008 Oct 08 SP - 189 EP - 198 VL - 269 IS - 2 KW - Receptors, Calcitriol KW - 0 KW - Index Medicus KW - Animals KW - Polymorphism, Single Nucleotide KW - Apoptosis KW - Receptors, Calcitriol -- genetics KW - DNA Methylation KW - Humans KW - Dietary Supplements KW - Epigenesis, Genetic KW - Genomics KW - Neoplasms -- prevention & control KW - Nutritional Physiological Phenomena KW - Neoplasms -- therapy KW - Neoplasms -- genetics KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69543769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Nutrition+and+cancer%3A+essential+elements+for+a+roadmap.&rft.au=Milner%2C+J+A&rft.aulast=Milner&rft.aufirst=J&rft.date=2008-10-08&rft.volume=269&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2008.05.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-14 N1 - Date created - 2008-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.canlet.2008.05.030 ER - TY - JOUR T1 - A heterogeneous dose distribution in simultaneous integrated boost: the role of the clonogenic cell density on the tumor control probability. AN - 69536087; 18758004 AB - IMRT with inverse planning allows simultaneous integrated boost strategies that exploit the heterogeneous dose distribution within the planning target volumes (PTVs). In this scenario, the location of cold spots within the target becomes a crucial issue and has to be related to the distribution of the clonogenic cell density (CCD). The main aim of this work is to provide the means to calculate the optimal prescription dose in a relative inhomogeneous dose distribution. To achieve this, the prescription dose has to be assigned to obtain the same tumor control probability (TCP) as the ideal homogeneous distribution, taking into account different CCDs in different PTVs (i.e. visible and subclinical regions). An adapted formulation of the linear-quadratic model, within the F-factor formalism, has been derived to preserve a chosen TCP value for the whole target volume. The F-factor has been investigated to show its potential applications in clinical practice. JF - Physics in medicine and biology AU - Strigari, L AU - D'Andrea, M AU - Abate, A AU - Benassi, M AD - Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy. strigari@ifo.it Y1 - 2008/10/07/ PY - 2008 DA - 2008 Oct 07 SP - 5257 EP - 5273 VL - 53 IS - 19 SN - 0031-9155, 0031-9155 KW - Index Medicus KW - Probability KW - Reproducibility of Results KW - Radiotherapy Dosage KW - Humans KW - Reference Standards KW - Algorithms KW - Radiotherapy, Intensity-Modulated KW - Time Factors KW - Radiation Dosage KW - Clone Cells -- pathology KW - Neoplasms -- pathology KW - Clone Cells -- radiation effects KW - Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69536087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+in+medicine+and+biology&rft.atitle=A+heterogeneous+dose+distribution+in+simultaneous+integrated+boost%3A+the+role+of+the+clonogenic+cell+density+on+the+tumor+control+probability.&rft.au=Strigari%2C+L%3BD%27Andrea%2C+M%3BAbate%2C+A%3BBenassi%2C+M&rft.aulast=Strigari&rft.aufirst=L&rft.date=2008-10-07&rft.volume=53&rft.issue=19&rft.spage=5257&rft.isbn=&rft.btitle=&rft.title=Physics+in+medicine+and+biology&rft.issn=00319155&rft_id=info:doi/10.1088%2F0031-9155%2F53%2F19%2F001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-10 N1 - Date created - 2008-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1088/0031-9155/53/19/001 ER - TY - CPAPER T1 - The role of Disabled in Axon Guidance T2 - 9th International Congress on Cell Biology (ICCB 2008) AN - 41103789; 4949486 JF - 9th International Congress on Cell Biology (ICCB 2008) AU - "Song,Jeongkuen" Y1 - 2008/10/07/ PY - 2008 DA - 2008 Oct 07 KW - Axon guidance KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41103789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Congress+on+Cell+Biology+%28ICCB+2008%29&rft.atitle=The+role+of+Disabled+in+Axon+Guidance&rft.au=%22Song%2CJeongkuen%22&rft.aulast=%22Song&rft.aufirst=Jeongkuen%22&rft.date=2008-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Congress+on+Cell+Biology+%28ICCB+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iccb2008.org/sub_pro.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppression of genomic instability by evolutionary conserved mechanisms T2 - 9th International Congress on Cell Biology (ICCB 2008) AN - 41101284; 4949362 JF - 9th International Congress on Cell Biology (ICCB 2008) AU - "Myung,Kyungjae " Y1 - 2008/10/07/ PY - 2008 DA - 2008 Oct 07 KW - Genomic instability KW - Evolutionary conservation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41101284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Congress+on+Cell+Biology+%28ICCB+2008%29&rft.atitle=Suppression+of+genomic+instability+by+evolutionary+conserved+mechanisms&rft.au=%22Myung%2CKyungjae+%22&rft.aulast=%22Myung&rft.aufirst=Kyungjae&rft.date=2008-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Congress+on+Cell+Biology+%28ICCB+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iccb2008.org/sub_pro.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Substitution treatment in Malaysia AN - 19619493; 8689796 AB - Less than 6 months after Richard Schottenfeld and colleagues terminated their buprenorphine versus naltrexone study in Malaysia (June 28, p 2192), super(1) the country's drug policy entered a new phase. Substitution treatment was introduced as a pilot programme in October, 2005. Methadone was prescribed through government hospitals, community clinics, and general practitioners' clinics, reaching 1241 heroin users within a year. The programme was subsequently scaled up, reaching the target of about 5000 people by the end of 2007, with a new target of 25 000 by 2010. JF - Lancet AU - Noordin, N M AU - Merican, MI AU - Rahman, HA AU - Lee, S S AU - Ramly, R AD - Department of Health Economics and Finance, Institute for Health Management, National Institutes of Health, Kuala Lumpur, Malaysia (NMN), sslee@cuhk.edu.hk Y1 - 2008/10/03/ PY - 2008 DA - 2008 Oct 03 SP - 1149 VL - 372 IS - 9644 SN - 0099-5355, 0099-5355 KW - Risk Abstracts KW - Malaysia KW - Drugs KW - heroin KW - Hospitals KW - R2 23090:Policy and planning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19619493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Substitution+treatment+in+Malaysia&rft.au=Noordin%2C+N+M%3BMerican%2C+MI%3BRahman%2C+HA%3BLee%2C+S+S%3BRamly%2C+R&rft.aulast=Noordin&rft.aufirst=N&rft.date=2008-10-03&rft.volume=372&rft.issue=9644&rft.spage=1149&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=00995355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Malaysia; heroin; Drugs; Hospitals ER - TY - JOUR T1 - Spin Trapping Investigation of Peroxide- and Isoniazid-Induced Radicals in Mycobacterium tuberculosis Catalase-Peroxidase AN - 754540313; 13264248 AB - A new approach, the immuno-spin trapping assay, used a novel rabbit polyclonal anti-DMPO (5,5-dimethyl-1-pyrroline N-oxide) antiserum to detect protein radical-derived DMPO nitrone adducts in the hemoprotein Mycobacterium tuberculosis catalase-peroxidase (KatG). This work demonstrates that the formation of protein nitrone adducts is dependent on the concentrations of tert-BuOOH and DMPO as shown by Western blotting and an enzyme-linked immunosorbent assay (ELISA). We have also detected protein-protein cross-links formed during turnover of Mtb KatG driven by tert-butyl peroxide (tert-BuOOH) or enzymatic generation of hydrogen peroxide. DMPO inhibits this dimerization due to its ability to trap the amino acid radicals responsible for the cross-linkage. Chemical modifications by tyrosine and tryptophan blockage suggest that tyrosine residues are one site of formation of the dimers. The presence of the tuberculosis drug isoniazid (INH) also prevented cross-linking as a result of its competition for the protein radical. Protein-DMPO nitrone adducts were also generated by a continuous flux of hydrogen peroxide. These findings demonstrated that the protein-based radicals were formed not only during Mtb KatG turnover with alkyl peroxides but also in the presence of hydrogen peroxide. Furthermore, the formation of protein-DMPO nitrone adducts was accelerated in the presence of isoniazid. JF - Biochemistry (Washington) AU - Ranguelova, Kalina AU - Suarez, Javier AU - Magliozzo, Richard S AU - Mason, Ronald P AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, MD F0-01, 111 T. W. Alexander Drive, Research Triangle Park, North Carolina 27709, Department of Biochemistry, The Graduate Center of the City University of New York, New York, New York 10016, and Department of Chemistry, Brooklyn College, Brooklyn, New York 11210 Y1 - 2008/10/02/ PY - 2008 DA - 2008 Oct 02 SP - 11377 EP - 11385 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA VL - 47 IS - 43 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Western blotting KW - Tryptophan KW - Enzyme-linked immunosorbent assay KW - Amino acids KW - Adducts KW - N-Oxides KW - Tyrosine KW - Trapping KW - Cross-linkage KW - Hydrogen peroxide KW - Tuberculosis KW - Competition KW - Drugs KW - Mycobacterium tuberculosis KW - Chemical modification KW - Isoniazid KW - Radicals KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754540313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Spin+Trapping+Investigation+of+Peroxide-+and+Isoniazid-Induced+Radicals+in+Mycobacterium+tuberculosis+Catalase-Peroxidase&rft.au=Ranguelova%2C+Kalina%3BSuarez%2C+Javier%3BMagliozzo%2C+Richard+S%3BMason%2C+Ronald+P&rft.aulast=Ranguelova&rft.aufirst=Kalina&rft.date=2008-10-02&rft.volume=47&rft.issue=43&rft.spage=11377&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi800952b L2 - http://pubs.acs.org/doi/abs/10.1021/bi800952b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Tryptophan; Western blotting; Enzyme-linked immunosorbent assay; Amino acids; Adducts; N-Oxides; Tyrosine; Trapping; Cross-linkage; Hydrogen peroxide; Tuberculosis; Drugs; Competition; Radicals; Isoniazid; Chemical modification; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1021/bi800952b ER - TY - CPAPER T1 - Measurement Issues in Pediatric Obesity Research T2 - 2008 Conference on Childhood and Adolescent Obesity AN - 41108590; 4949873 JF - 2008 Conference on Childhood and Adolescent Obesity AU - "Huang, Terry" Y1 - 2008/10/02/ PY - 2008 DA - 2008 Oct 02 KW - Obesity KW - Pediatrics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41108590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Conference+on+Childhood+and+Adolescent+Obesity&rft.atitle=Measurement+Issues+in+Pediatric+Obesity+Research&rft.au=%22Huang%2C+Terry%22&rft.aulast=%22Huang&rft.aufirst=Terry%22&rft.date=2008-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Conference+on+Childhood+and+Adolescent+Obesity&rft.issn=&rft_id=info:doi/ L2 - http://www.interprofessional.ubc.ca/Brochures/Brochure_Child%20Obesity 08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A 200 MHz flexible array for (F)MRI of macaques in a vertical scanner T2 - 25th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2008) AN - 41104367; 4947864 JF - 25th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2008) AU - "Merkle, HellmutNB " AU - "Logothetis, N. " AU - "Goense, J. " Y1 - 2008/10/02/ PY - 2008 DA - 2008 Oct 02 KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41104367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2008%29&rft.atitle=A+200+MHz+flexible+array+for+%28F%29MRI+of+macaques+in+a+vertical+scanner&rft.au=%22Merkle%2C+HellmutNB+%22%3B%22Logothetis%2C+N.+%22%3B%22Goense%2C+J.+%22&rft.aulast=%22Merkle&rft.aufirst=HellmutNB&rft.date=2008-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esmrmb.org/cms/website.php?id=/en/esmrmb_congress_2008/scie ntificprogramme.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Research priorities in spasmodic dysphonia. AN - 85401812; pmid-18922334 AB - To identify research priorities to increase understanding of the pathogenesis, diagnosis, and improved treatment of spasmodic dysphonia.A multidisciplinary working group was formed that included both scientists and clinicians from multiple disciplines (otolaryngology, neurology, speech pathology, genetics, and neuroscience) to review currently available information on spasmodic dysphonia and to identify research priorities.Operational definitions for spasmodic dysphonia at different levels of certainty were recommended for diagnosis and recommendations made for a multicenter multidisciplinary validation study.The highest priority is to characterize the disorder and identify risk factors that may contribute to its onset. Future research should compare and contrast spasmodic dysphonia with other forms of focal dystonia. Development of animal models is recommended to explore hypotheses related to pathogenesis. Improved understanding of the pathophysiology of spasmodic dysphonia should provide the basis for developing new treatment options and exploratory clinical trials.This document should foster future research to improve the care of patients with this chronic debilitating voice and speech disorder by otolaryngology, neurology, and speech pathology. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Ludlow, Christy L AU - Adler, Charles H AU - Berke, Gerald S AU - Bielamowicz, Steven A AU - Blitzer, Andrew AU - Bressman, Susan B AU - Hallett, Mark AU - Jinnah, H A AU - Juergens, Uwe AU - Martin, Sandra B AU - Perlmutter, Joel S AU - Sapienza, Christine AU - Singleton, Andrew AU - Tanner, Caroline M AU - Woodson, Gayle E AD - Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 495 EP - 505 VL - 139 SN - 0194-5998, 0194-5998 KW - National Library of Medicine KW - Botulinum Toxins, Type A: administration & dosage KW - Humans KW - Laryngoscopy KW - Neuromuscular Agents: administration & dosage KW - Recurrent Laryngeal Nerve: surgery KW - *Research KW - Risk Factors KW - Voice Disorders: diagnosis KW - Voice Disorders: epidemiology KW - Voice Disorders: physiopathology KW - Voice Disorders: surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85401812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Research+priorities+in+spasmodic+dysphonia.&rft.au=Ludlow%2C+Christy+L%3BAdler%2C+Charles+H%3BBerke%2C+Gerald+S%3BBielamowicz%2C+Steven+A%3BBlitzer%2C+Andrew%3BBressman%2C+Susan+B%3BHallett%2C+Mark%3BJinnah%2C+H+A%3BJuergens%2C+Uwe%3BMartin%2C+Sandra+B%3BPerlmutter%2C+Joel+S%3BSapienza%2C+Christine%3BSingleton%2C+Andrew%3BTanner%2C+Caroline+M%3BWoodson%2C+Gayle+E&rft.aulast=Ludlow&rft.aufirst=Christy&rft.date=2008-10-01&rft.volume=139&rft.issue=&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-06-04 N1 - SuppNotes - Cites: Adv Neurol. 1998;78:161-8[9750913]; 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AN - 69917327; 19106445 AB - Iron is an essential trace metal required by all living organisms and is toxic in excess. Nature has evolved a delicately balanced network to monitor iron entry, transport it to sites of need, and serve as a unique storage and recycling system, in the absence of an excretory system, to remove excess iron. Due to the unique nature of iron metabolism, iron homeostasis is achieved by integrated specialized mechanisms that operate at the cellular and organism level. The use of positional cloning approaches by multiple researchers has led to the identification and characterization of various proteins and peptides that play a critical role in iron metabolism. These efforts have led to elucidation of the molecular mechanisms involved in the uptake of iron by the enterocytes, transportation across the membrane to circulation, and delivery to diverse tissues for use and storage and sensor system to co-ordinate and achieve homeostasis. Molecular understanding of these processes and the key regulatory molecules involved in maintaining homeostasis will provide novel insights into understanding human disorders associated with either iron deficiency or overload. JF - The Indian journal of medical research AU - Nadadur, S S AU - Srirama, K AU - Mudipalli, Anuradha AD - Division of Extramural Research & Training, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. nadadurs@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 533 EP - 544 VL - 128 IS - 4 SN - 0971-5916, 0971-5916 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Humans KW - Biological Transport KW - Homeostasis KW - Iron -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69917327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Indian+journal+of+medical+research&rft.atitle=Iron+transport+%26amp%3B+homeostasis+mechanisms%3A+their+role+in+health+%26amp%3B+disease.&rft.au=Nadadur%2C+S+S%3BSrirama%2C+K%3BMudipalli%2C+Anuradha&rft.aulast=Nadadur&rft.aufirst=S&rft.date=2008-10-01&rft.volume=128&rft.issue=4&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=The+Indian+journal+of+medical+research&rft.issn=09715916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-30 N1 - Date created - 2008-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The road to the crystal structure of the cytochrome bc1 complex from the anoxigenic, photosynthetic bacterium Rhodobacter sphaeroides. AN - 69832904; 18953640 AB - The advantages of using bacterial systems to study the mechanism and function of cytochrome bc (1) complexes do not extend readily to their structural investigations. High quality crystals of bacterial complexes have been difficult to obtain despite the enzymes' smaller sizes and simpler subunit compositions compared to their mitochondrial counterparts. In the course of the structure determination of the bc (1) complex from R. sphaeroides, we observed that the growth of only low quality crystals correlated with low activity and stability of the purified complex, which was mitigated in part by introducing a double mutations to the enzyme. The S287R(cyt b)/V135S(ISP) mutant shows 40% increase in electron transfer activity and displays a 4.3 degrees C increase in thermal stability over wild-type enzyme. The amino acid histidine was found important in maintaining structural integrity of the bacterial complex, while the respiratory inhibitors such as stigmatellin are required for immobilization of the iron-sulfur protein extrinsic domain. Crystal quality of the R. sphaeroides bc (1) complex can be improved further by the presence of strontium ions yielding crystals that diffracted X-rays to better than 2.3 A resolution. The improved crystal quality can be understood in terms of participation of strontium ions in molecular packing arrangement in crystal. JF - Journal of bioenergetics and biomembranes AU - Xia, Di AU - Esser, Lothar AU - Elberry, Maria AU - Zhou, Fei AU - Yu, Linda AU - Yu, Chang-An AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. dixia@helix.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 485 EP - 492 VL - 40 IS - 5 SN - 0145-479X, 0145-479X KW - Recombinant Proteins KW - 0 KW - Histidine KW - 4QD397987E KW - Electron Transport Complex III KW - EC 1.10.2.2 KW - Strontium KW - YZS2RPE8LE KW - Index Medicus KW - Anisotropy KW - Models, Molecular KW - Recombinant Proteins -- genetics KW - Histidine -- chemistry KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- isolation & purification KW - Strontium -- chemistry KW - Recombinant Proteins -- metabolism KW - Enzyme Stability KW - Crystallization -- methods KW - Crystallography, X-Ray KW - Recombinant Proteins -- chemistry KW - Protein Conformation KW - Rhodobacter sphaeroides -- genetics KW - Electron Transport Complex III -- genetics KW - Rhodobacter sphaeroides -- enzymology KW - Electron Transport Complex III -- chemistry KW - Electron Transport Complex III -- metabolism KW - Electron Transport Complex III -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69832904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bioenergetics+and+biomembranes&rft.atitle=The+road+to+the+crystal+structure+of+the+cytochrome+bc1+complex+from+the+anoxigenic%2C+photosynthetic+bacterium+Rhodobacter+sphaeroides.&rft.au=Xia%2C+Di%3BEsser%2C+Lothar%3BElberry%2C+Maria%3BZhou%2C+Fei%3BYu%2C+Linda%3BYu%2C+Chang-An&rft.aulast=Xia&rft.aufirst=Di&rft.date=2008-10-01&rft.volume=40&rft.issue=5&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Journal+of+bioenergetics+and+biomembranes&rft.issn=0145479X&rft_id=info:doi/10.1007%2Fs10863-008-9180-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10863-008-9180-8 ER - TY - JOUR T1 - [New guidelines against unfair treatment of narcotic addicts necessary]. TT - Nya riktlinjer behövs mot övergrepp i narkomanvården. AN - 69827709; 19031975 JF - Lakartidningen AU - Heilig, Markus AU - Gunne, Lars AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. markus.heilig@mail.nih.gov PY - 2008 SP - 3093 EP - 3094 VL - 105 IS - 44 SN - 0023-7205, 0023-7205 KW - Narcotics KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Humans KW - Practice Guidelines as Topic KW - Buprenorphine -- administration & dosage KW - Narcotics -- administration & dosage KW - Outcome Assessment (Health Care) KW - Methadone -- administration & dosage KW - Health Policy KW - Sweden KW - Drug Users KW - Opioid-Related Disorders -- rehabilitation KW - Patient Rights UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69827709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lakartidningen&rft.atitle=%5BNew+guidelines+against+unfair+treatment+of+narcotic+addicts+necessary%5D.&rft.au=Heilig%2C+Markus%3BGunne%2C+Lars&rft.aulast=Heilig&rft.aufirst=Markus&rft.date=2008-10-01&rft.volume=105&rft.issue=44&rft.spage=3093&rft.isbn=&rft.btitle=&rft.title=Lakartidningen&rft.issn=00237205&rft_id=info:doi/ LA - Swedish DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-01 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Medical countermeasures against nuclear threats: radionuclide decorporation agents. AN - 69814063; 19024661 AB - Exposure to radionuclides disseminated by a radiological dispersion device or deposited as fallout after a nuclear power plant accident or detonation of an improvised nuclear device could result in internal contamination of a significant number of individuals. Internalized radionuclides may cause both acute and chronic radiation injury and increase an individual's risk of developing cancer. This damage and risk can be mitigated by the use of decorporation agents that reduce internal contamination. Unfortunately, most effective agents decorporate only a limited range of radionuclides, and some are formulated in ways that would make administration in mass casualty situations challenging. There is a need for new radionuclide decorporation agents, reformulations of existing agents, and/or expansion of the labeled indications for existing treatments. Researchers developing novel or improved decorporation agents should also understand the regulatory pathway for these products. This workshop, the first in nearly half a century to focus exclusively on radionuclide decorporation, brought together researchers and scientific administrators from academia, government and industry as well as senior regulatory affairs officers and U.S. Food and Drug Administration personnel. Meeting participants reviewed recent progress in the development of decorporation agents and contemplated the future of the field. JF - Radiation research AU - Cassatt, David R AU - Kaminski, Joseph M AU - Hatchett, Richard J AU - DiCarlo, Andrea L AU - Benjamin, Jessica M AU - Maidment, Bert W Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 540 EP - 548 VL - 170 IS - 4 KW - Chelating Agents KW - 0 KW - Radioactive Fallout KW - Radioisotopes KW - Index Medicus KW - Space life sciences KW - Chelating Agents -- therapeutic use KW - Chelating Agents -- chemistry KW - Radioactive Hazard Release KW - Humans KW - Radioactive Fallout -- adverse effects KW - Nuclear Weapons KW - Radiation Injuries -- prevention & control KW - Radioisotopes -- chemistry KW - Radioisotopes -- toxicity KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69814063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Radiation+research&rft.atitle=Medical+countermeasures+against+nuclear+threats%3A+radionuclide+decorporation+agents.&rft.au=Cassatt%2C+David+R%3BKaminski%2C+Joseph+M%3BHatchett%2C+Richard+J%3BDiCarlo%2C+Andrea+L%3BBenjamin%2C+Jessica+M%3BMaidment%2C+Bert+W&rft.aulast=Cassatt&rft.aufirst=David&rft.date=2008-10-01&rft.volume=170&rft.issue=4&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-07 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protective effect of dietary phytochemicals against arsenite induced genotoxicity in mammalian V79 cells. AN - 69805655; 19024166 AB - Chronic arsenic exposure causes skin diseases, gastrointestinal and neurological disorders, diabetes and cancer in various organs. Oxidative stress associated with arsenic exposure cause genetic instabilities and may initiate carcinogenesis. Phytochemicals present in vegetables, fruits, spices, tea, and medicinal plants, have shown to suppress experimental carcinogenesis in various organs. The aim of the present study was to elucidate the protective effect of some of the phytochemicals against the arsenite induced DNA damage in normal mammalian V79 cells. Comet assay was used for assessment of DNA damage and 2', 7'-dichlorofluorescein dihydroacetate for estimation of ROS generated by arsenite. The effect of the phytochemicals was observed during simultaneous treatment with arsenic, before arsenite exposure and during repair experiments. Of all the phytochemicals tested against arsenic, curcumin gave better protection during simultaneous treatment and resveratrol during pre treatment, which was evident both from comet assay and ROS generation experiments. During pre treatment a longer duration of treatment with lower dose of phytochemicals proved fruitful in reducing the genotoxicity. During repair experiments the phytochemicals enhanced recovery of DNA damage and ellagic acid gave promising results. The results indicated that natural phytochemicals may have the efficacy in reducing arsenic induced genotoxicity, in scavenging ROS and in enhancing the process of DNA repair in V79 cells. JF - Indian journal of experimental biology AU - Roy, Madhumita AU - Sinha, Dona AU - Mukherjee, Sutapa AU - Paul, Susmita AU - Bhattacharya, R K AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Kolkata 700 026, India. mitacnci@yahoo.co.in Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 690 EP - 697 VL - 46 IS - 10 SN - 0019-5189, 0019-5189 KW - Arsenites KW - 0 KW - Flavonoids KW - Mutagens KW - Reactive Oxygen Species KW - Stilbenes KW - Ellagic Acid KW - 19YRN3ZS9P KW - Curcumin KW - IT942ZTH98 KW - arsenite KW - N5509X556J KW - resveratrol KW - Q369O8926L KW - Capsaicin KW - S07O44R1ZM KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Comet Assay KW - Animals KW - Ellagic Acid -- pharmacology KW - Cricetulus KW - Stilbenes -- pharmacology KW - DNA Damage KW - Flavonoids -- pharmacology KW - Cell Line KW - Curcumin -- pharmacology KW - Cricetinae KW - Capsaicin -- pharmacology KW - Arsenites -- toxicity KW - Mutagens -- toxicity KW - Diet KW - Arsenites -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69805655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+experimental+biology&rft.atitle=Protective+effect+of+dietary+phytochemicals+against+arsenite+induced+genotoxicity+in+mammalian+V79+cells.&rft.au=Roy%2C+Madhumita%3BSinha%2C+Dona%3BMukherjee%2C+Sutapa%3BPaul%2C+Susmita%3BBhattacharya%2C+R+K&rft.aulast=Roy&rft.aufirst=Madhumita&rft.date=2008-10-01&rft.volume=46&rft.issue=10&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+experimental+biology&rft.issn=00195189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-07 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Urinary elimination of 11-nor-9-carboxy-delta9-tetrahydrocannnabinol in cannabis users during continuously monitored abstinence. AN - 69783994; 19007504 AB - The time course of 11-nor-9-carboxy-Delta9-tetrahydrocannnabinol (THCCOOH) elimination in urine was characterized in 60 cannabis users during 24 h monitored abstinence on a closed research unit for up to 30 days. Six thousand, one hundred fifty-eight individual urine specimens were screened by immunoassay with values > or = 50 ng/mL classified as positive. Urine specimens were confirmed for THCCOOH by gas chromatography-mass spectrometry following base hydrolysis and liquid-liquid or solid-phase extraction. In 60%, the maximum creatinine normalized concentration occurred in the first urine specimen; in 40%, peaks occurred as long as 2.9 days after admission. Data were divided into three groups, 0-50, 51-150, and > 150 ng/mg, based on the creatinine corrected initial THCCOOH concentration. There were statistically significant correlations between groups and number of days until first negative and last positive urine specimens; mean number of days were 0.6 and 4.3, 3.2 and 9.7, and 4.7 and 15.4 days, respectively, for the three groups. These data provide guidelines for interpreting urine cannabinoid test results and suggest appropriate detection windows for differentiating new cannabis use from residual drug excretion. JF - Journal of analytical toxicology AU - Goodwin, Robert S AU - Darwin, William D AU - Chiang, C Nora AU - Shih, Ming AU - Li, Shou-Hua AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Rockville, Maryland, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 562 EP - 569 VL - 32 IS - 8 SN - 0146-4760, 0146-4760 KW - 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid KW - 4TPC9E4A32 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Female KW - Marijuana Abuse -- urine KW - Dronabinol -- analogs & derivatives KW - Marijuana Abuse -- diagnosis KW - Substance Abuse Detection -- methods KW - Dronabinol -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69783994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Urinary+elimination+of+11-nor-9-carboxy-delta9-tetrahydrocannnabinol+in+cannabis+users+during+continuously+monitored+abstinence.&rft.au=Goodwin%2C+Robert+S%3BDarwin%2C+William+D%3BChiang%2C+C+Nora%3BShih%2C+Ming%3BLi%2C+Shou-Hua%3BHuestis%2C+Marilyn+A&rft.aulast=Goodwin&rft.aufirst=Robert&rft.date=2008-10-01&rft.volume=32&rft.issue=8&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-04 N1 - Date created - 2008-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Anal Toxicol. 2000 May-Jun;24(4):245-9 [10872570] J Anal Toxicol. 1998 Oct;22(6):445-54 [9788519] J Anal Toxicol. 2001 Oct;25(7):550-4 [11599598] Drug Alcohol Depend. 2002 Dec 1;68(3):285-97 [12393223] Clin Chem. 1980 Jul;26(8):1119-26 [6156031] J Pharmacol Exp Ther. 1980 Oct;215(1):35-44 [6256518] Am J Psychiatry. 1982 Sep;139(9):1196-8 [6287871] Hum Toxicol. 1983 Oct;2(4):641-4 [6642522] Aviat Space Environ Med. 1983 Nov;54(11):1031-3 [6316902] J Subst Abuse Treat. 1984;1(4):265-70 [6399325] Clin Pharmacol Ther. 1985 Nov;38(5):572-8 [3902318] J Anal Toxicol. 1987 Jan-Feb;11(1):1-5 [3029505] J Anal Toxicol. 1989 Jul-Aug;13(4):218-23 [2550702] J Anal Toxicol. 1992 Jul-Aug;16(4):228-35 [1323733] J Anal Toxicol. 2001 Oct;25(7):538-49 [11599597] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Strategies for addressing global environmental health concerns. AN - 69762543; 18991900 AB - While each region of the world faces unique public health challenges, environmental threats to vulnerable populations in Asia constitute a significant global public health challenge. Environmental threats to health are widespread and are increasing as nations in the region undergo rapid industrial development. One of the major predictors of ill health is poverty. Regional poverty puts large populations at risk for ill health, which exacerbates poverty and increases the exposure risk to environmental factors, such as pollution and disease. Patterns of illness have changed dramatically in the last century, and will continue to change in this century. Chemical toxicants in the environment, poverty, and little or no access to health care are all factors contributing to life-threatening diseases. Therefore, it is vital that we develop a better understanding of the mechanisms and interactions between nutrition, infectious disease, environmental exposures, and genetic predisposition in order to develop better prevention methods. JF - Annals of the New York Academy of Sciences AU - Suk, William A AU - Davis, E Ann AD - NIH-National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. suk@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 40 EP - 44 VL - 1140 KW - Environmental Pollutants KW - 0 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Environment KW - Arsenic -- toxicity KW - Air Pollution, Indoor KW - Humans KW - Child KW - Biomass KW - Global Health KW - Risk KW - Public Health KW - Risk Factors KW - Genetic Predisposition to Disease KW - Environmental Pollution KW - Environmental Health KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69762543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Strategies+for+addressing+global+environmental+health+concerns.&rft.au=Suk%2C+William+A%3BDavis%2C+E+Ann&rft.aulast=Suk&rft.aufirst=William&rft.date=2008-10-01&rft.volume=1140&rft.issue=&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1454.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-03 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1454.046 ER - TY - JOUR T1 - Addiction Reviews. Introduction. AN - 69759153; 18991948 JF - Annals of the New York Academy of Sciences AU - Volkow, Nora D AD - National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - xi EP - xii VL - 1141 KW - Index Medicus KW - Humans KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69759153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Addiction+Reviews.+Introduction.&rft.au=Volkow%2C+Nora+D&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2008-10-01&rft.volume=1141&rft.issue=&rft.spage=xi&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1441.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-12 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1441.034 ER - TY - JOUR T1 - Identification of two late acyltransferase genes responsible for lipid A biosynthesis in Moraxella catarrhalis. AN - 69728576; 18795947 AB - Lipid A is a biological component of the lipo-oligosaccharide of a human pathogen, Moraxella catarrhalis. No other acyltransferases except for UDP-GlcNAc acyltransferase, responsible for lipid A biosynthesis in M. catarrhalis, have been identified. By bioinformatics, two late acyltransferase genes, lpxX and lpxL, responsible for lipid A biosynthesis were identified, and knockout mutants of each gene in M. catarrhalis strain O35E were constructed and named O35ElpxX and O35ElpxL. Structural analysis of lipid A from the parental strain and derived mutants showed that O35ElpxX lacked two decanoic acids (C10:0), whereas O35ElpxL lacked one dodecanoic (lauric) acid (C12:0), suggesting that lpxX encoded decanoyl transferase and lpxL encoded dodecanoyl transferase. Phenotypic analysis revealed that both mutants were similar to the parental strain in their toxicity in vitro. However, O35ElpxX was sensitive to the bactericidal activity of normal human serum and hydrophobic reagents. It had a reduced growth rate in broth and an accelerated bacterial clearance at 3 h (P < 0.01) or 6 h (P < 0.05) after an aerosol challenge in a murine model of bacterial pulmonary clearance. O35ElpxL presented similar patterns to those of the parental strain, except that it was slightly sensitive to the hydrophobic reagents. These results indicate that these two genes, particularly lpxX, encoding late acyltransferases responsible for incorporation of the acyloxyacyl-linked secondary acyl chains into lipid A, are important for the biological activities of M. catarrhalis. JF - The FEBS journal AU - Gao, Song AU - Peng, Daxin AU - Zhang, Wenhong AU - Muszyński, Artur AU - Carlson, Russell W AU - Gu, Xin-Xing AD - Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 5201 EP - 5214 VL - 275 IS - 20 KW - Bacterial Proteins KW - 0 KW - Lipid A KW - Acyltransferases KW - EC 2.3.- KW - LpxL protein, bacteria KW - Index Medicus KW - Animals KW - Base Sequence KW - Bacterial Proteins -- genetics KW - Blood -- microbiology KW - Humans KW - Molecular Sequence Data KW - Mice KW - Mutation KW - Acyltransferases -- genetics KW - Lipid A -- biosynthesis KW - Lipid A -- chemistry KW - Moraxella (Branhamella) catarrhalis -- genetics KW - Moraxella (Branhamella) catarrhalis -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69728576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+FEBS+journal&rft.atitle=Identification+of+two+late+acyltransferase+genes+responsible+for+lipid+A+biosynthesis+in+Moraxella+catarrhalis.&rft.au=Gao%2C+Song%3BPeng%2C+Daxin%3BZhang%2C+Wenhong%3BMuszy%C5%84ski%2C+Artur%3BCarlson%2C+Russell+W%3BGu%2C+Xin-Xing&rft.aulast=Gao&rft.aufirst=Song&rft.date=2008-10-01&rft.volume=275&rft.issue=20&rft.spage=5201&rft.isbn=&rft.btitle=&rft.title=The+FEBS+journal&rft.issn=1742-4658&rft_id=info:doi/10.1111%2Fj.1742-4658.2008.06651.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-10-30 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - EU155138; GENBANK; EU155137 N1 - SuppNotes - Cited By: J Exp Med. 2000 Mar 20;191(6):949-60 [10727457] Microbes Infect. 2000 Apr;2(5):547-59 [10865200] Infect Immun. 2000 Sep;68(9):4980-5 [10948114] Infect Immun. 2000 Sep;68(9):5261-8 [10948153] Infect Immun. 2001 Mar;69(3):1358-63 [11179299] Infect Immun. 2001 Oct;69(10):5981-90 [11553534] Comput Chem. 2001 Dec;26(1):51-6 [11765852] Clin Microbiol Rev. 2002 Jan;15(1):125-44 [11781271] Infect Immun. 2002 Feb;70(2):909-20 [11796626] J Bacteriol. 2002 May;184(9):2379-88 [11948150] Annu Rev Biochem. 2002;71:635-700 [12045108] Infect Immun. 2002 Aug;70(8):4661-8 [12117980] Infect Immun. 2003 Feb;71(2):647-55 [12540541] Microb Pathog. 2003 Mar;34(3):121-30 [12631473] Infect Immun. 2003 Sep;71(9):4977-84 [12933840] Infect Immun. 2003 Nov;71(11):6426-34 [14573664] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W321-6 [15215403] Anal Biochem. 1982 Jan 1;119(1):115-9 [6176137] Carbohydr Res. 1988 Apr 15;175(2):273-82 [2900066] J Clin Microbiol. 1990 Feb;28(2):182-7 [2107197] Clin Microbiol Rev. 1990 Oct;3(4):293-320 [2121328] J Bacteriol. 1992 Feb;174(3):702-10 [1732206] Infect Immun. 1992 Sep;60(9):3824-9 [1500191] Infect Immun. 1993 May;61(5):2003-10 [7683000] Microbiol Rev. 1993 Sep;57(3):655-82 [7504166] Antimicrob Agents Chemother. 1993 Nov;37(11):2255-60 [8285603] Eur J Biochem. 1994 Feb 15;220(1):209-16 [8119289] Pediatr Infect Dis J. 1994 Jan;13(1 Suppl 1):S23-6; discussion S50-4 [8159511] Carbohydr Res. 1994 May 5;257(2):269-84 [7516823] Comput Appl Biosci. 1994 Dec;10(6):685-6 [7704669] J Biol Chem. 1995 Nov 10;270(45):27151-9 [7592970] J Biol Chem. 1996 May 17;271(20):12095-102 [8662613] Microbiol Rev. 1996 Jun;60(2):267-79 [8801433] J Biol Chem. 1997 Apr 18;272(16):10353-60 [9099672] J Bacteriol. 1997 Sep;179(17):5521-33 [9287009] Infect Immun. 1998 May;66(5):1891-7 [9573066] J Bacteriol. 1999 Feb;181(4):1099-109 [9973334] J Biol Chem. 1999 Apr 2;274(14):9677-85 [10092655] Eur J Biochem. 1999 Oct;265(2):524-9 [10504382] Infect Immun. 2005 Apr;73(4):2400-10 [15784586] J Bacteriol. 2005 May;187(9):2939-47 [15838019] Infect Immun. 2005 Jul;73(7):4222-30 [15972513] Am J Respir Crit Care Med. 2005 Jul 15;172(2):195-9 [15805178] Infect Immun. 2005 Nov;73(11):7569-77 [16239560] J Clin Microbiol. 2005 Dec;43(12):6139-43 [16333114] J Bacteriol. 2006 Feb;188(4):1381-8 [16452420] Plasmid. 2006 Sep;56(2):133-7 [16757025] Carbohydr Res. 2006 Nov 6;341(15):2600-6 [16934238] Bioinformatics. 2007 Mar 15;23(6):673-9 [17237039] Annu Rev Biochem. 2007;76:295-329 [17362200] Infect Immun. 2007 Nov;75(11):5518-31 [17724076] Glycobiology. 2008 Jun;18(6):447-55 [18337458] Erratum In: FEBS J. 2009 Jul;276(13):3683 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1742-4658.2008.06651.x ER - TY - JOUR T1 - Influence of Helicobacter hepaticus infection on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice. AN - 69717130; 18812577 AB - Helicobacter hepaticus (H. hepaticus) infection causes hepatitis and increased hepatocellular neoplasms in male mice; although females are also infected, liver lesions are not typically expressed. In the 1990s, B6C3F1 mice from some chronic National Toxicology Program (NTP) studies were found to be infected with H. hepaticus. In these studies, there was hepatitis in many of the males, and there were more hepatocellular neoplasms in control males compared to studies with uninfected mice. In one of these studies, increased hepatocellular neoplasms at the high doses in male and female mice exposed topically to triethanolamine (TEA) provided the only evidence of carcinogenic activity. This study was repeated in mice free of H. hepaticus.However, the NTP mouse production colony and the diet differed between studies; these differences were the result of NTP programmatic decisions. In repeat study males, although control incidences were similar between studies, exposure did not result in increased hepatocellular neoplasms. In repeat study females, the control incidence of hepatocellular neoplasms was half that observed in the initial study, and these neoplasms were increased over controls at all doses. These data suggest that in the initial study, H. hepaticusinfluenced the induction of hepatocellular neoplasms in males, but not in females. JF - Toxicologic pathology AU - Stout, Matthew D AU - Kissling, Grace E AU - Suárez, Fernando A AU - Malarkey, David E AU - Herbert, Ronald A AU - Bucher, John R AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 783 EP - 794 VL - 36 IS - 6 KW - Carcinogens KW - 0 KW - Ethanolamines KW - triethanolamine KW - 9O3K93S3TK KW - Index Medicus KW - Hepatitis -- microbiology KW - Animals KW - Liver -- pathology KW - Sex Characteristics KW - Skin -- pathology KW - Mice KW - Kaplan-Meier Estimate KW - Mice, Inbred Strains KW - Logistic Models KW - Liver Diseases -- pathology KW - Liver Diseases -- etiology KW - Female KW - Male KW - Proportional Hazards Models KW - Carcinogens -- administration & dosage KW - Chemical and Drug Induced Liver Injury KW - Helicobacter Infections -- complications KW - Carcinogens -- toxicity KW - Liver Neoplasms -- chemically induced KW - Toxicity Tests, Chronic -- methods KW - Liver Neoplasms -- pathology KW - Ethanolamines -- administration & dosage KW - Helicobacter hepaticus KW - Carcinogenicity Tests -- methods KW - Ethanolamines -- toxicity KW - Liver Neoplasms -- etiology KW - Helicobacter Infections -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69717130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Influence+of+Helicobacter+hepaticus+infection+on+the+chronic+toxicity+and+carcinogenicity+of+triethanolamine+in+B6C3F1+mice.&rft.au=Stout%2C+Matthew+D%3BKissling%2C+Grace+E%3BSu%C3%A1rez%2C+Fernando+A%3BMalarkey%2C+David+E%3BHerbert%2C+Ronald+A%3BBucher%2C+John+R&rft.aulast=Stout&rft.aufirst=Matthew&rft.date=2008-10-01&rft.volume=36&rft.issue=6&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308322312 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-11 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Pathol. 2003 Mar-Apr;31(2):243-50 [12696586] Int J Cancer. 2008 Feb 15;122(4):832-8 [17957786] Toxicol Pathol. 2004 Nov-Dec;32(6):668-77 [15513910] Biometrics. 1971 Mar;27(1):103-17 [5547548] Biometrics. 1972 Jun;28(2):519-31 [5037867] Biometrics. 1988 Jun;44(2):417-31 [3390507] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] J Natl Cancer Inst. 1994 Aug 17;86(16):1222-7 [8040890] J Clin Microbiol. 1994 May;32(5):1238-45 [8051250] Am J Pathol. 1994 Oct;145(4):959-68 [7943185] J Clin Microbiol. 1995 Nov;33(11):2968-72 [8576355] Am J Pathol. 1996 Feb;148(2):509-17 [8579113] Infect Immun. 1996 Sep;64(9):3673-81 [8751916] In Vivo. 1996 May-Jun;10(3):285-92 [8797029] J Nutr. 1997 May;127(5 Suppl):842S-846S [9164250] Toxicol Pathol. 1997 May-Jun;25(3):256-63 [9210256] Am J Pathol. 1997 Oct;151(4):933-41 [9327726] Toxicol Pathol. 1997 Nov-Dec;25(6):591-6 [9437804] Toxicol Pathol. 1997 Nov-Dec;25(6):597-605 [9437805] Toxicol Pathol. 1998 Sep-Oct;26(5):602-11 [9789946] J Clin Microbiol. 2007 Jul;45(7):2166-72 [17507523] Natl Toxicol Program Tech Rep Ser. 2004 May;(518):5-163 [15213765] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308322312 ER - TY - JOUR T1 - Smoking knowledge and behavior in the United States: sociodemographic, smoking status, and geographic patterns. AN - 69698661; 18946775 AB - Smoking is the leading cause of preventable death in the United States and has been linked to several dire health consequences including cancer and cardiovascular disease. However, knowledge of the associated risks of tobacco use may not be evenly distributed within the population. We analyzed data from the National Cancer Institute's Health Information National Trends Survey (HINTS, 2003) to characterize current knowledge of cancer prevention and smoking risk in the adult U.S. population and to identify associated sociodemographic, smoking status, and geographic factors. To account for the complex survey design of HINTS, SUDAAN was used to calculate population estimates and confidence intervals. Geographic Information System (GIS) isopleth maps were generated to examine smoking behavior and knowledge. Females, non-Hispanic Whites, those with higher incomes, and former smokers (compared with current smokers) were more likely to reject smoking myths. More accurate smoking risk beliefs were reported by respondents with some college (OR = 1.76) and college degrees (OR = 2.13) compared with those with less than a high school education. Former smokers (OR = 2.53) and never-smokers (OR = 3.26) reported more accurate risk beliefs than current smokers. Knowledge of lung cancer mortality was lower among females (OR = 0.38), older adults (OR age 65-79 = 0.69; OR age 80+ = 0.48), and non-Hispanic Blacks (OR = 0.64). GIS analyses revealed lower knowledge of smoking risk and higher tobacco use in the regions with higher tobacco production and higher tobacco-related mortality. Disparities in tobacco-related knowledge, morbidity, and mortality underscore the need for continued development and delivery of effective prevention and treatment interventions to reduce the population burden of tobacco-related disease. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Finney Rutten, Lila J AU - Augustson, Erik M AU - Moser, Richard P AU - Beckjord, Ellen Burke AU - Hesse, Bradford W AD - Division of Cancer Control and Population Sciences, Behavioral Research Program, Health Communication and Informatics Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. finneyl@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1559 EP - 1570 VL - 10 IS - 10 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - Socioeconomic Factors KW - Educational Status KW - Risk Factors KW - Humans KW - Health Status KW - United States -- epidemiology KW - Sex Distribution KW - Population Surveillance KW - Attitude to Health -- ethnology KW - Health Knowledge, Attitudes, Practice KW - Health Behavior -- ethnology KW - Tobacco Use Disorder -- ethnology KW - Tobacco Use Disorder -- prevention & control KW - Smoking -- ethnology KW - Smoking -- prevention & control KW - Ethnic Groups -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69698661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Smoking+knowledge+and+behavior+in+the+United+States%3A+sociodemographic%2C+smoking+status%2C+and+geographic+patterns.&rft.au=Finney+Rutten%2C+Lila+J%3BAugustson%2C+Erik+M%3BMoser%2C+Richard+P%3BBeckjord%2C+Ellen+Burke%3BHesse%2C+Bradford+W&rft.aulast=Finney+Rutten&rft.aufirst=Lila&rft.date=2008-10-01&rft.volume=10&rft.issue=10&rft.spage=1559&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/10.1080%2F14622200802325873 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/14622200802325873 ER - TY - JOUR T1 - E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. AN - 69680141; 18722373 AB - Resistance to apoptosis is essential for cancer growth. We previously reported that hepatic coexpression of c-Myc and E2F1, 2 key regulators of proliferation and apoptosis, enhanced hepatocellular carcinoma (HCC) development in transgenic mice. Here, we investigated the molecular mechanisms underlying oncogenic cooperation between c-Myc and E2F1 in relationship to human liver cancer. Activation of pro- and antiapoptotic cascades was assessed by immunoblotting in experimental HCC models and in human HCC. Effect of antisense oligodeoxy nucleotides against c-Myc and E2F1 was studied in human HCC cell lines. Suppression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase (PIK3CA)/Akt, mammalian target of rapamycin (mTOR), and cyclooxygenase (COX)-2 pathways was achieved by pharmacologic inhibitors and small interfering RNA in human and mouse HCC cell lines. Coexpression with E2F1 did not increase proliferation triggered by c-Myc overexpression but conferred a strong resistance to c-Myc-initiated apoptosis via concomitant induction of PIK3CA/Akt/mTOR and c-Myb/COX-2 survival pathways. COX-2 was not induced in c-Myc and rarely in E2F1 tumors. In human HCC, PIK3CA/Akt/mTOR and c-Myb/COX-2 pathways were similarly activated, with levels of PIK3CA/Akt, mTOR, and c-Myb being inversely associated with patients' survival length. Silencing c-Myc and E2F1 reduced PIK3CA/Akt and mTOR and completely abolished c-Myb and COX-2 expression in human HCC cell lines. Finally, simultaneous inhibition of PIK3CA/Akt/mTOR and COX-2 activity in in vitro models caused massive apoptosis of neoplastic hepatocytes. E2F1 may function as a critical antiapoptotic factor both in human and in rodent liver cancer through its ability to counteract c-Myc-driven apoptosis via activation of PIK3CA/Akt/mTOR and c-Myb/COX-2 pathways. JF - Gastroenterology AU - Ladu, Sara AU - Calvisi, Diego F AU - Conner, Elizabeth A AU - Farina, Miriam AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4262, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1322 EP - 1332 VL - 135 IS - 4 KW - Carrier Proteins KW - 0 KW - E2F1 Transcription Factor KW - E2F1 protein, human KW - E2f1 protein, mouse KW - MYC protein, human KW - Multiprotein Complexes KW - Myc protein, mouse KW - Proteins KW - Proto-Oncogene Proteins c-myc KW - Transcription Factors KW - mechanistic target of rapamycin complex 1 KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Phosphotransferases (Alcohol Group Acceptor) KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - mTOR protein, mouse KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Ribosomal Protein S6 Kinases, 70-kDa KW - Abridged Index Medicus KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Carrier Proteins -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Transcription Factors -- metabolism KW - Humans KW - Transgenes -- physiology KW - Aged KW - Disease Models, Animal KW - Mice KW - Ribosomal Protein S6 Kinases, 70-kDa -- metabolism KW - Mice, Transgenic KW - Cyclooxygenase 2 -- metabolism KW - Middle Aged KW - Phosphotransferases (Alcohol Group Acceptor) -- metabolism KW - Cell Survival -- physiology KW - Female KW - Male KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - E2F1 Transcription Factor -- metabolism KW - Apoptosis -- physiology KW - Carcinoma, Hepatocellular -- pathology KW - E2F1 Transcription Factor -- genetics KW - Liver Neoplasms -- physiopathology KW - Proto-Oncogene Proteins c-myc -- metabolism KW - Carcinoma, Hepatocellular -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69680141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=E2F1+inhibits+c-Myc-driven+apoptosis+via+PIK3CA%2FAkt%2FmTOR+and+COX-2+in+a+mouse+model+of+human+liver+cancer.&rft.au=Ladu%2C+Sara%3BCalvisi%2C+Diego+F%3BConner%2C+Elizabeth+A%3BFarina%2C+Miriam%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Ladu&rft.aufirst=Sara&rft.date=2008-10-01&rft.volume=135&rft.issue=4&rft.spage=1322&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2008.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Growth Differ. 1998 Feb;9(2):113-8 [9486847] J Cell Physiol. 1997 Nov;173(2):233-6 [9365528] Genes Dev. 1998 Aug 1;12(15):2245-62 [9694791] Mol Cell. 2004 Dec 3;16(5):831-7 [15574337] Clin Cancer Res. 2004 Dec 15;10(24):8421-5 [15623621] Mol Cancer Res. 2004 Dec;2(12):685-91 [15634757] Cancer. 2005 Jan 15;103(2):307-12 [15593087] Cancer Res. 2005 May 1;65(9):3633-42 [15867358] J Hepatol. 2005 Jun;42(6):842-9 [15885355] Clin Cancer Res. 2005 Jul 1;11(13):4948-54 [16000594] Cancer Cell. 2005 Sep;8(3):179-83 [16169463] Curr Opin Cell Biol. 2005 Dec;17(6):596-603 [16226444] Nat Rev Cancer. 2005 Dec;5(12):921-9 [16341083] Cancer Cell. 2006 May;9(5):341-9 [16697955] Cancer Res. 2006 Jul 15;66(14):7059-66 [16849551] Hepatology. 2006 Oct;44(4):1003-11 [17006931] EMBO J. 2006 Oct 18;25(20):4795-807 [17006541] Cancer Cell. 2008 Jan;13(1):11-22 [18167336] Oncogene. 2002 Sep 19;21(42):6498-509 [12226753] Biochem Biophys Res Commun. 2003 Feb 28;302(1):114-20 [12593856] Hepatology. 2003 Sep;38(3):756-68 [12939602] Trends Cell Biol. 2003 Sep;13(9):478-83 [12946627] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10848-53 [12954980] Trends Biochem Sci. 2003 Nov;28(11):573-6 [14607085] Carcinogenesis. 2004 Mar;25(3):333-41 [14604889] Cancer Res. 2004 Jun 1;64(11):3844-8 [15172992] Hepatology. 2004 Sep;40(3):667-76 [15349906] J Environ Pathol Toxicol. 1979 Dec;3(1-2):329-51 [575723] Science. 1985 Jun 14;228(4705):1313-5 [4001943] Nature. 1986 Nov 20-26;324(6094):276-9 [3024010] Proc Natl Acad Sci U S A. 1989 May;86(10):3594-8 [2524830] Science. 1990 Nov 23;250(4984):1149-51 [2251503] Nucleic Acids Res. 1991 Aug 11;19(15):4293 [1870982] Genes Dev. 2000 Oct 1;14(19):2393-409 [11018009] Oncogene. 2000 Oct 19;19(44):5054-62 [11042693] Mol Cell Biol. 2001 Feb;21(3):893-901 [11154276] Nature. 2001 May 17;411(6835):342-8 [11357141] J Biochem. 2001 Jul;130(1):1-8 [11432772] Mol Cell. 2001 Jul;8(1):105-13 [11511364] Clin Cancer Res. 2001 Nov;7(11):3590-7 [11705881] Nat Rev Cancer. 2002 Jul;2(7):489-501 [12094235] Science. 1992 Oct 16;258(5081):424-9 [1411535] Cancer Res. 1993 Apr 15;53(8):1719-23 [8467484] Nature. 1993 Sep 23;365(6444):349-52 [8377827] Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3602-6 [8170954] Science. 1994 Sep 30;265(5181):2091-3 [8091232] Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7245-50 [9207076] J Biol Chem. 1998 Apr 17;273(16):9373-7 [9545260] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1053/j.gastro.2008.07.012 ER - TY - JOUR T1 - Male contraception: what is on the horizon? AN - 69652608; 18847595 AB - Male contraception remains an important area of research. Methods can inhibit sperm production or can be targeted to inhibit sperm functions such as motility, orientation or interaction with the egg. Hormonal methods appear to be safe and effective in proof of concept studies but efforts are underway to improve delivery options or lead time until full efficacy is achieved. Nonhormonal methods are based on numerous targets that impact sperm production or function. Several agents that inhibit the sperm-specific or testis-specific targets have been identified and studies in animals have shown promising results. JF - Contraception AU - Blithe, Diana AD - Contraception and Reproductive Health Branch, Center for Population Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. blithed@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - S23 EP - S27 VL - 78 IS - 4 Suppl SN - 0010-7824, 0010-7824 KW - Contraceptive Agents, Male KW - 0 KW - Spermatogenesis-Blocking Agents KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Index Medicus KW - Animals KW - Humans KW - Gonadotropin-Releasing Hormone -- antagonists & inhibitors KW - Forecasting KW - Male KW - Spermatogenesis-Blocking Agents -- therapeutic use KW - Contraceptive Agents, Male -- pharmacology KW - Spermatogenesis-Blocking Agents -- pharmacology KW - Contraception -- methods KW - Contraceptive Agents, Male -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69652608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contraception&rft.atitle=Male+contraception%3A+what+is+on+the+horizon%3F&rft.au=Blithe%2C+Diana&rft.aulast=Blithe&rft.aufirst=Diana&rft.date=2008-10-01&rft.volume=78&rft.issue=4+Suppl&rft.spage=S23&rft.isbn=&rft.btitle=&rft.title=Contraception&rft.issn=00107824&rft_id=info:doi/10.1016%2Fj.contraception.2008.03.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.contraception.2008.03.018 ER - TY - JOUR T1 - Adjuvant mitotane for adrenocortical cancer--a recurring controversy. AN - 69649518; 18842984 JF - The Journal of clinical endocrinology and metabolism AU - Huang, Hui AU - Fojo, Tito AD - Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. huangh@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 3730 EP - 3732 VL - 93 IS - 10 SN - 0021-972X, 0021-972X KW - Antineoplastic Agents, Hormonal KW - 0 KW - Mitotane KW - 78E4J5IB5J KW - Abridged Index Medicus KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Neoplasm Metastasis KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Antineoplastic Agents, Hormonal -- adverse effects KW - Recurrence KW - Chemotherapy, Adjuvant KW - Adrenal Cortex Neoplasms -- pathology KW - Mitotane -- administration & dosage KW - Mitotane -- therapeutic use KW - Carcinoma -- pathology KW - Carcinoma -- drug therapy KW - Adrenal Cortex Neoplasms -- drug therapy KW - Mitotane -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69649518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Adjuvant+mitotane+for+adrenocortical+cancer--a+recurring+controversy.&rft.au=Huang%2C+Hui%3BFojo%2C+Tito&rft.aulast=Huang&rft.aufirst=Hui&rft.date=2008-10-01&rft.volume=93&rft.issue=10&rft.spage=3730&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/10.1210%2Fjc.2008-0579 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-24 N1 - Date created - 2008-10-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2007 Jun 7;356(23):2372-80 [17554118] N Engl J Med. 2007 Sep 20;357(12):1256-7; author reply 1259 [17881760] Cancer. 2001 Sep 15;92(6):1385-92 [11745214] J Clin Endocrinol Metab. 2000 Jun;85(6):2234-8 [10852456] Eur J Cancer Clin Oncol. 1984 Jan;20(1):47-53 [6537915] Am J Med. 1966 Oct;41(4):572-80 [5923598] JAMA. 1973 Mar 5;223(10):1109-12 [4739370] J Steroid Biochem. 1973 Nov;4(6):585-91 [4789318] Cancer. 1978 Nov;42(5):2177-81 [719602] Comment In: J Clin Endocrinol Metab. 2009 Jun;94(6):1879-80 [19494162] Comment On: J Clin Endocrinol Metab. 2000 Jun;85(6):2234-8 [10852456] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/jc.2008-0579 ER - TY - JOUR T1 - Impregnated netting slows infestation by Triatoma infestans. AN - 69641231; 18840739 AB - We used sentinel animal enclosures to measure the rate of infestation by the Chagas disease vector, Triatoma infestans, in an urban community of Arequipa, Peru, and to evaluate the effect of deltamethrin-impregnated netting on that rate. Impregnated netting decreased the rate of infestation of sentinel enclosures (rate ratio, 0.23; 95% confidence interval, 0.13-0.38; P < 0.001), controlling for the density of surrounding vector populations and the distance of these to the sentinel enclosures. Most migrant insects were early-stage nymphs, which are less likely to carry the parasitic agent of Chagas disease, Trypanosoma cruzi. Spread of the vector in the city therefore likely precedes spread of the parasite. Netting was particularly effective against adult insects and late-stage nymphs; taking into account population structure, netting decreased the reproductive value of migrant populations from 443.6 to 40.5. Impregnated netting can slow the spread of T. infestans and is a potentially valuable tool in the control of Chagas disease. JF - The American journal of tropical medicine and hygiene AU - Levy, Michael Z AU - Quíspe-Machaca, Victor R AU - Ylla-Velasquez, Jose L AU - Waller, Lance A AU - Richards, Jean M AU - Rath, Bruno AU - Borrini-Mayori, Katty AU - del Carpio, Juan G Cornejo AU - Cordova-Benzaquen, Eleazar AU - McKenzie, F Ellis AU - Wirtz, Robert A AU - Maguire, James H AU - Gilman, Robert H AU - Bern, Caryn AD - Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892-2220, USA. levymz@yahoo.com Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 528 EP - 534 VL - 79 IS - 4 KW - Insecticides KW - 0 KW - Nitriles KW - Pyrethrins KW - decamethrin KW - 2JTS8R821G KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Population Density KW - Poisson Distribution KW - Nitriles -- pharmacology KW - Triatoma KW - Insect Vectors KW - Pyrethrins -- pharmacology KW - Insect Control -- methods KW - Chagas Disease -- transmission KW - Insecticides -- pharmacology KW - Chagas Disease -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69641231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.atitle=Impregnated+netting+slows+infestation+by+Triatoma+infestans.&rft.au=Levy%2C+Michael+Z%3BQu%C3%ADspe-Machaca%2C+Victor+R%3BYlla-Velasquez%2C+Jose+L%3BWaller%2C+Lance+A%3BRichards%2C+Jean+M%3BRath%2C+Bruno%3BBorrini-Mayori%2C+Katty%3Bdel+Carpio%2C+Juan+G+Cornejo%3BCordova-Benzaquen%2C+Eleazar%3BMcKenzie%2C+F+Ellis%3BWirtz%2C+Robert+A%3BMaguire%2C+James+H%3BGilman%2C+Robert+H%3BBern%2C+Caryn&rft.aulast=Levy&rft.aufirst=Michael&rft.date=2008-10-01&rft.volume=79&rft.issue=4&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+tropical+medicine+and+hygiene&rft.issn=1476-1645&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trans R Soc Trop Med Hyg. 2007 Apr;101(4):360-7 [17097698] Emerg Infect Dis. 2006 Sep;12(9):1345-52 [17073082] PLoS Negl Trop Dis. 2007;1(3):e103 [18160979] PLoS Med. 2007 Dec;4(12):e332 [18162039] Science. 2001 Jul 27;293(5530):694-8 [11474111] Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:405-11 [10677766] Clin Infect Dis. 2008 Jun 15;46(12):1822-8 [18462104] Am J Trop Med Hyg. 2001 Dec;65(6):861-4 [11791988] Mem Inst Oswaldo Cruz. 2002 Jul;97(5):603-12 [12219120] Am J Trop Med Hyg. 2003 Mar;68(3):307-11 [12685636] JAMA. 2004 Jun 2;291(21):2571-80 [15173148] J Med Entomol. 2004 Jul;41(4):614-21 [15311452] J Med Entomol. 1972 Aug 1;9(4):351-70 [4559948] Annu Rev Entomol. 1981;26:101-33 [6791582] Med Vet Entomol. 1988 Oct;2(4):401-4 [2980200] Med Vet Entomol. 1993 Jul;7(3):238-42 [7690269] Gastroenterol Clin North Am. 1996 Sep;25(3):517-33 [8863038] J Med Entomol. 1996 Jan;33(1):15-26 [8906900] Rev Panam Salud Publica. 1997 Apr;1(4):273-9 [9149523] Am J Trop Med Hyg. 1998 Jun;58(6):748-58 [9660458] Trop Med Int Health. 1999 Mar;4(3):194-8 [10223214] Am J Trop Med Hyg. 2004 Dec;71(6):803-10 [15642975] Am Nat. 2007 Sep;170(3):421-30 [17879192] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of two PCR-based human papillomavirus genotyping methods. AN - 69633033; 18716224 AB - We compared two consensus primer PCR human papillomavirus (HPV) genotyping methods for the detection of individual HPV genotypes and carcinogenic HPV genotypes as a group, using a stratified sample of enrollment cervical specimens from sexually active women participating in the NCI/Costa Rica HPV16/18 Vaccine Efficacy Trial. For the SPF(10) method, DNA was extracted from 0.1% of the cervical specimen by using a MagNA Pure LC instrument, a 65-bp region of the HPV L1 gene was targeted for PCR amplification by using SPF(10) primers, and 25 genotypes were detected by reverse-line blot hybridization of the amplicons. For the Linear Array (LA) method, DNA was extracted from 0.5% of the cervical specimen by using an MDx robot, a 450-bp region of the HPV L1 gene was targeted for PCR amplification by using PGMY09/11 L1 primers, and 37 genotypes were detected by reverse-line blot hybridization of the amplicons. Specimens (n = 1,427) for testing by the LA method were randomly selected from strata defined on the basis of enrollment test results from the SPF(10) method, cytology, and Hybrid Capture 2. LA results were extrapolated to the trial cohort (n = 5,659). The LA and SPF(10) methods detected 21 genotypes in common; HPV16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -66, -68, and -73 were considered the carcinogenic HPV genotypes. There was no difference in the overall results for grouped detection of carcinogenic HPV by the SPF(10) and LA methods (35.3% versus 35.9%, respectively; P = 0.5), with a 91.8% overall agreement and a kappa value of 0.82. In comparisons of individual HPV genotypes, the LA method detected significantly more HPV16, HPV18, HPV39, HPV58, HPV59, HPV66, and HPV68/73 and less HPV31 and HPV52 than the SPF(10) method; inclusion of genotype-specific testing for HPV16 and HPV18 for those specimens testing positive for HPV by the SPF(10) method but for which no individual HPV genotype was detected abrogated any differences between the LA and SPF(10) methods. The LA method detected more carcinogenic-HPV-genotype infections per specimen than the SPF(10) method (P < 0.001). In conclusion, the LA method and the SPF(10) method with HPV16 and HPV18 genotype-specific detection among ungenotyped HPV-positive specimens were comparable for detection of HPV16 and HPV18, the two HPV genotypes targeted by current prophylactic HPV vaccines. Both approaches are suitable for monitoring the impact of HPV16/18 vaccines in clinical trials. JF - Journal of clinical microbiology AU - Castle, Philip E AU - Porras, Carolina AU - Quint, Wim G AU - Rodriguez, Ana Cecilia AU - Schiffman, Mark AU - Gravitt, Patti E AU - González, Paula AU - Katki, Hormuzd A AU - Silva, Sandra AU - Freer, Enrique AU - Van Doorn, Leen-Jan AU - Jiménez, Silvia AU - Herrero, Rolando AU - Hildesheim, Allan AU - CVT Group AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 5004, EPS MSC 7234, Bethesda, MD 20892-7234. castlep@mail.nih.gov. ; CVT Group Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 3437 EP - 3445 VL - 46 IS - 10 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Costa Rica KW - Adult KW - Cervix Uteri -- virology KW - DNA, Viral -- isolation & purification KW - Adolescent KW - DNA, Viral -- genetics KW - Female KW - Papillomavirus Infections -- diagnosis KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Polymerase Chain Reaction -- methods KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69633033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Comparison+of+two+PCR-based+human+papillomavirus+genotyping+methods.&rft.au=Castle%2C+Philip+E%3BPorras%2C+Carolina%3BQuint%2C+Wim+G%3BRodriguez%2C+Ana+Cecilia%3BSchiffman%2C+Mark%3BGravitt%2C+Patti+E%3BGonz%C3%A1lez%2C+Paula%3BKatki%2C+Hormuzd+A%3BSilva%2C+Sandra%3BFreer%2C+Enrique%3BVan+Doorn%2C+Leen-Jan%3BJim%C3%A9nez%2C+Silvia%3BHerrero%2C+Rolando%3BHildesheim%2C+Allan%3BCVT+Group&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-10-01&rft.volume=46&rft.issue=10&rft.spage=3437&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=1098-660X&rft_id=info:doi/10.1128%2FJCM.00620-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-27 N1 - Date created - 2008-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] N Engl J Med. 2003 Feb 6;348(6):489-90 [12571255] Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):485-90 [12814991] J Clin Microbiol. 1996 Mar;34(3):745-7 [8904451] Am J Pathol. 1998 Dec;153(6):1731-9 [9846964] J Clin Microbiol. 1999 Aug;37(8):2508-17 [10405393] J Pathol. 1999 Sep;189(1):12-9 [10451482] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1149-56 [15894665] Am J Clin Pathol. 2005 Jun;123(6):896-9 [15899782] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Am J Clin Pathol. 2005 Nov;124(5):722-32 [16203281] J Clin Microbiol. 2006 Sep;44(9):3122-9 [16954236] J Clin Microbiol. 2006 Nov;44(11):3915-7 [16971652] J Infect Dis. 2006 Nov 1;194(9):1291-9 [17041856] J Clin Microbiol. 2006 Sep;44(9):3292-8 [16954263] J Clin Microbiol. 2007 May;45(5):1447-54 [17344361] N Engl J Med. 2007 May 10;356(19):1915-27 [17494925] N Engl J Med. 2007 May 10;356(19):1928-43 [17494926] J Virol Methods. 2007 Jul;143(1):45-54 [17399803] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Lancet. 2007 Jun 30;369(9580):2161-70 [17602732] JAMA. 2007 Aug 15;298(7):743-53 [17699008] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] J Clin Microbiol. 2007 Nov;45(11):3821-3 [17898159] J Virol Methods. 2008 Feb;147(2):290-6 [17996311] J Clin Microbiol. 2008 Jan;46(1):109-17 [17989194] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1248-54 [18483347] Am J Epidemiol. 2008 Jul 15;168(2):138-44; discussion 145-8 [18483124] Am J Epidemiol. 2008 Jul 15;168(2):123-37 [18483125] Vaccine. 2008 Sep 2;26(37):4795-808 [18640170] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] JAMA. 2000 Jan 5;283(1):87-93 [10632285] J Infect Dis. 2001 Jun 1;183(11):1554-64 [11343204] Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1129-36 [11700260] Cancer Epidemiol Biomarkers Prev. 2003 Apr;12(4):372-9 [12692113] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JCM.00620-08 ER - TY - JOUR T1 - Addressing the intersecting problems of opioid misuse and chronic pain treatment. AN - 69632842; 18837638 AB - Misuse of prescription opioid medications has continued as a major public health problem in the United States. Review of major epidemiologic databases shows that the prevalence of opioid misuse rose markedly through the 1990s and the early part of the current decade. In this same period of time, the number of prescriptions for chronic noncancer pain increased markedly, and the intersection of these two public health problems remains a concern. Further, despite some leveling off of the overall rate of prescription opioid misuse in the past several years, surveillance data show high and increasing mortality associated with these drugs. Analysis of the 2006 National Survey of Drug Use and Health indicates the increasing prevalence of prescription opioid misuse is associated more with an increase in the general availability of these medications than misuse of the medications by those who were directly prescribed them. National Institute on Drug Abuse initiatives to address the prescription opioid problem include programs to stimulate research in the basic and clinical sciences, and to educate physicians and other health personnel. Copyright (c) 2008 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Denisco, Richard A AU - Chandler, Redonna K AU - Compton, Wilson M AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, Bethesda, MD 20892-9589, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 417 EP - 428 VL - 16 IS - 5 SN - 1064-1297, 1064-1297 KW - Analgesics, Opioid KW - 0 KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Humans KW - Chronic Disease KW - Terminology as Topic KW - Pain -- complications KW - Pain -- drug therapy KW - Opioid-Related Disorders -- epidemiology KW - Opioid-Related Disorders -- psychology KW - Opioid-Related Disorders -- complications KW - Analgesics, Opioid -- therapeutic use KW - Pain -- epidemiology KW - Analgesics, Opioid -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69632842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Addressing+the+intersecting+problems+of+opioid+misuse+and+chronic+pain+treatment.&rft.au=Denisco%2C+Richard+A%3BChandler%2C+Redonna+K%3BCompton%2C+Wilson+M&rft.aulast=Denisco&rft.aufirst=Richard&rft.date=2008-10-01&rft.volume=16&rft.issue=5&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0013636 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-10-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Pain Headache Rep. 2007 Aug;11(4):276-82 [17686391] Spine (Phila Pa 1976). 2007 Aug 15;32(18):2012-8 [17700450] Arch Intern Med. 2007 Sep 10;167(16):1752-9 [17846394] Clin J Pain. 2007 Oct;23(8):648-60 [17885342] Pain Med. 2007 Mar;8(2):171-83 [17305688] Arch Gen Psychiatry. 2007 Mar;64(3):379-80; author reply 381-2 [17339528] Clin J Pain. 2007 May;23(4):303-6 [17449990] Pain Suppl. 1986;3:S1-226 [3461421] Drugs. 1991 Aug;42(2):228-39 [1717222] N Z Med J. 1991 Dec 11;104(925):520-1 [1758664] J Pain Symptom Manage. 1992 Feb;7(2):69-77 [1573287] Lancet. 1993 Apr 24;341(8852):1075-6 [8096970] J Pain Symptom Manage. 1993 Jul;8(5):279-88 [7525744] Drug Alcohol Depend. 2007 Dec 1;91(2-3):115-20 [17590285] Respiration. 2007;74(6):663-73 [17622755] Lancet. 1999 Dec;354 Suppl:SIV1 [10691419] JAMA. 2000 Apr 5;283(13):1710-4 [10755497] J Womens Health Gend Based Med. 2000 Apr;9(3):289-97 [10787224] J Pain Symptom Manage. 2000 Sep;20(3):180-92 [11018336] Pain. 2001 Jan;89(2-3):127-34 [11166468] J Pain Symptom Manage. 2001 Sep;22(3):791-6 [11532592] J Gen Intern Med. 2002 Mar;17(3):173-9 [11929502] Pain. 2002 Dec;100(3):213-7 [12467992] Drug Alcohol Depend. 2003 Apr 1;69(3):215-32 [12633908] Eur J Cancer Care (Engl). 2003 Mar;12(1):28-34 [12641554] JAMA. 2003 Nov 12;290(18):2443-54 [14612481] N Engl J Med. 2003 Nov 13;349(20):1943-53 [14614170] Oncologist. 2003;8(6):567-75 [14657535] Pain. 2003 Dec;106(3):221-8 [14659505] Subst Use Misuse. 2004 Jan;39(1):1-23 [15002942] Spine (Phila Pa 1976). 2004 Apr 15;29(8):884-90; discussion 891 [15082989] J Pain Palliat Care Pharmacother. 2004;18(1):31-46 [15148007] Pain. 2004 Jun;109(3):207-9 [15157679] Pain. 2004 Jun;109(3):514-9 [15157714] J Pain Symptom Manage. 2004 Aug;28(2):176-88 [15276196] Lancet. 2004 Aug 28-Sep 3;364(9436):739-40 [15337386] Pain Med. 2004 Sep;5(3):301-2 [15367310] Novartis Found Symp. 2004;261:181-6; discussion 187-93 [15469051] Pain. 1986 May;25(2):171-86 [2873550] Clin J Pain. 1995 Mar;11(1):6-21 [7787338] Clin J Pain. 1995 Dec;11(4):267-78 [8788574] Clin J Pain. 1995 Dec;11(4):279-86 [8788575] JAMA. 1998 Jul 8;280(2):147-51 [9669787] Br J Anaesth. 1998 Jul;81(1):58-68 [9771273] Lancet. 1999 May 29;353(9167):1865-9 [10359427] JAMA. 2005 Jan 19;293(3):297-8 [15657321] J Pain Palliat Care Pharmacother. 2005;19(1):13-26 [15814511] J Pain. 2005 Oct;6(10):662-72 [16202959] Am J Public Health. 2005 Nov;95(11):2042-8 [16195508] J Ethn Subst Abuse. 2005;4(2):97-114 [16275636] Pain Med. 2005 Nov-Dec;6(6):432-42 [16336480] Drug Alcohol Depend. 2006 Feb 1;81(2):103-7 [16023304] Curr Pain Headache Rep. 2006 Feb;10(1):67-70 [16499832] Drug Alcohol Depend. 2006 Jun;83 Suppl 1:S4-7 [16563663] Drug Alcohol Rev. 2006 Mar;25(2):173-5 [16627308] J Emerg Nurs. 2006 Jun;32(3):219-24 [16730276] BMC Health Serv Res. 2006;6:46 [16595013] J Clin Psychiatry. 2006 Jul;67(7):1062-73 [16889449] Pharmacoepidemiol Drug Saf. 2006 Sep;15(9):618-27 [16862602] Curr Psychiatry Rep. 2006 Oct;8(5):377-82 [16968618] Eur Addict Res. 2006;12(4):187-96 [16968994] Am J Ther. 2006 Sep-Oct;13(5):436-44 [16988540] Clin J Pain. 2006 Oct;22(8):717-24 [16988568] CMAJ. 2006 Nov 21;175(11):1385 [17116905] Pediatrics. 2006 Dec;118(6):2472-80 [17142533] Ann Intern Med. 2007 Jan 16;146(2):116-27 [17227935] Pain. 2007 Jun;129(3):355-62 [17449178] Drug Saf. 2007;30(6):533-40 [17536879] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1037/a0013636 ER - TY - JOUR T1 - Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. AN - 69624663; 18632753 AB - Aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs) are carcinogens present in tobacco smoke and functional polymorphisms in NAT2 and GSTM1 metabolizing genes are associated with increased bladder cancer risk. We evaluated whether genetic variation in other candidate metabolizing genes are also associated with risk. Candidates included genes that control the transcription of metabolizing genes [aryl hydrocarbon receptor (AHR), AHRR and aryl hydrocarbon nuclear translocator (ARNT)] and genes that activate/detoxify AA or PAH (AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EPHX1, EPHX2, NQO1, MPO, UGT1A4, SULT1A1 and SULT1A2). Using genotype data from 1150 cases of urothelial carcinomas and 1149 controls from the Spanish Bladder Cancer Study, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) adjusting for age, gender, region and smoking status. Based on a test for trend, we observed 10 non-redundant single-nucleotide polymorphisms (SNPs) in five genes (AKR1C3, ARNT, CYP1A1, CYP1B1 and SULT1A2) significantly associated with bladder cancer risk. We observed an inverse association with risk for the AKR1C3 promoter SNP rs1937845 [OR (95% CI) for heterozygote and homozygote variant compared with common homozygote genotype were 0.86 (0.70-1.06) and 0.74 (0.57-0.96), respectively; P for trend = 0.02]. Interestingly, genetic variation in this region has been associated with lung, non-Hodgkin lymphoma and prostate cancer risk. Analysis of additional SNPs to capture most (approximately 90%) of common genetic variation in AKR1C3 and haplotype walking analyses based on all AKR1C3 SNPs (n = 25) suggest two separate regions associated with bladder cancer risk. These results indicate that genetic variation in carcinogen-metabolizing genes, particularly AKR1C3, could be associated with bladder cancer risk. JF - Carcinogenesis AU - Figueroa, Jonine D AU - Malats, Núria AU - García-Closas, Montserrat AU - Real, Francisco X AU - Silverman, Debra AU - Kogevinas, Manolis AU - Chanock, Stephen AU - Welch, Robert AU - Dosemeci, Mustafa AU - Lan, Qing AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Castaño-Vinyals, Gemma AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. figueroaj@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1955 EP - 1962 VL - 29 IS - 10 KW - ARNT protein, human KW - 0 KW - Aryl Hydrocarbon Receptor Nuclear Translocator KW - 138391-32-9 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - 3-Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - AKR1C3 protein, human KW - EC 1.1.1.- KW - Hydroxyprostaglandin Dehydrogenases KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1B1 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Genetic Variation KW - Cytochrome P-450 CYP1A1 -- genetics KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Aged KW - Glutathione Transferase -- genetics KW - Genotype KW - Promoter Regions, Genetic KW - Haplotypes KW - Aged, 80 and over KW - Aryl Hydrocarbon Receptor Nuclear Translocator -- genetics KW - Risk Factors KW - Adult KW - Middle Aged KW - Male KW - Female KW - Polymorphism, Single Nucleotide KW - Urinary Bladder Neoplasms -- etiology KW - 3-Hydroxysteroid Dehydrogenases -- genetics KW - Hydroxyprostaglandin Dehydrogenases -- genetics KW - Urinary Bladder Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69624663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Bladder+cancer+risk+and+genetic+variation+in+AKR1C3+and+other+metabolizing+genes.&rft.au=Figueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BGarc%C3%ADa-Closas%2C+Montserrat%3BReal%2C+Francisco+X%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BLan%2C+Qing%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BRothman%2C+Nathaniel&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2008-10-01&rft.volume=29&rft.issue=10&rft.spage=1955&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn163 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-14 N1 - Date created - 2008-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2000 Oct;83(8):998-1002 [10993645] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78 [17507624] Biochem J. 2000 Oct 1;351(Pt 1):67-77 [10998348] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] J Biol Chem. 2002 Jul 5;277(27):24799-808 [11978787] Mutat Res. 2002 Sep 30;506-507:29-40 [12351142] Mutat Res. 2002 Sep 30;506-507:65-77 [12351146] Carcinogenesis. 2002 Nov;23(11):1839-49 [12419832] Cancer Lett. 2003 Dec 8;202(1):61-9 [14643027] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] World J Urol. 2004 Feb;21(6):382-91 [14648102] Curr Drug Metab. 2004 Jun;5(3):211-24 [15180491] Hematol Oncol Clin North Am. 1992 Feb;6(1):1-30 [1556044] Cancer Epidemiol Biomarkers Prev. 1992 Jan-Feb;1(2):149-53 [1306098] IARC Sci Publ. 1993;(124):331-40 [8225503] Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8413-7 [8078896] Oncol Res. 1994;6(10-11):525-32 [7620221] Br J Cancer. 1995 Sep;72(3):555-61 [7669561] Mutat Res. 1997 May 12;376(1-2):135-42 [9202749] Cancer Causes Control. 1997 May;8(3):346-55 [9498898] Cancer Causes Control. 1997 May;8(3):444-72 [9498904] J Biochem. 1998 Nov;124(5):940-6 [9792917] Toxicol Lett. 1998 Dec 28;102-103:173-83 [10022251] Pharmacogenetics. 1999 Feb;9(1):113-21 [10208650] Carcinogenesis. 2004 Nov;25(11):2177-81 [15284179] Genet Epidemiol. 2004 Dec;27(4):348-64 [15543638] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Pharmacogenomics J. 2007 Aug;7(4):282-9 [16983398] Arch Biochem Biophys. 2007 Aug 15;464(2):241-50 [17537398] Mutat Res. 2007 Dec 1;625(1-2):72-82 [17612574] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):979-87 [16702380] Nat Clin Pract Urol. 2006 Jun;3(6):327-40 [16763645] Toxicol Lett. 2006 Aug 20;165(2):182-94 [16713138] Expert Opin Drug Metab Toxicol. 2005 Aug;1(2):187-202 [16922636] Toxicol Lett. 2006 Dec 15;167(3):212-20 [17069994] PLoS Genet. 2007 Feb 23;3(2):e29 [17319747] Hum Genet. 2007 Apr;121(2):161-8 [17149600] Genet Epidemiol. 2000 Dec;19(4):323-32 [11108642] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn163 ER - TY - JOUR T1 - Latent membrane protein 1 of Epstein-Barr virus activates the hTERT promoter and enhances telomerase activity in B lymphocytes. AN - 69618824; 18684838 AB - Transformation of primary B lymphocytes by Epstein-Barr virus requires the establishment of a strictly latent infection, the expression of several latent viral proteins, and sustained telomerase activity. Our previous findings indicated that induction of hTERT, the rate-limiting catalytic unit of the telomerase complex, was associated with the expression of the viral latent membrane protein 1 (LMP1). In the present study, we demonstrate that ectopic expression of LMP1 in BJAB and Ramos B cells resulted in an increase of hTERT transcripts, thus suggesting that LMP1 acts at the transcriptional level. This was confirmed by transient expression of a luciferase reporter plasmid containing the hTERT promoter cotransfected with an LMP1-expressing vector or transfected into B cells in which LMP1 expression was inducible. Consistently, silencing of LMP1 by small interfering RNA resulted in a reduction of hTERT transcripts. We also provide evidence indicating that LMP1-induced hTERT activation is independently mediated by NF-kappaB and by mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 pathways, whereas CD40, Akt, and mTOR signaling has no involvement. Moreover, our results do not support a role for c-Myc in mediating these effects on hTERT, since ectopic expression of LMP1 did not upregulate c-Myc and silencing of this oncogene or E box mutagenesis failed to inhibit LMP1-induced hTERT activation. These findings indicate that LMP1 simultaneously modulates multiple signal transduction pathways in B cells to transactivate the hTERT promoter and enhance telomerase activity, thus confirming the pleiotropic nature of this viral oncoprotein. JF - Journal of virology AU - Terrin, Liliana AU - Dal Col, Jessica AU - Rampazzo, Enrica AU - Zancai, Paola AU - Pedrotti, Moreno AU - Ammirabile, Grazia AU - Bergamin, Stefano AU - Rizzo, Silvana AU - Dolcetti, Riccardo AU - De Rossi, Anita AD - Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico-IRCCS, National Cancer Institute, Via Franco Gallini 2, 33081 Aviano (PN), Italy. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 10175 EP - 10187 VL - 82 IS - 20 KW - Antigens, CD40 KW - 0 KW - EBV-associated membrane antigen, Epstein-Barr virus KW - RNA, Small Interfering KW - Transcription Factor RelA KW - Viral Matrix Proteins KW - Protein Kinases KW - EC 2.7.- KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Telomerase KW - EC 2.7.7.49 KW - Index Medicus KW - Mitogen-Activated Protein Kinase 1 -- genetics KW - Proto-Oncogene Proteins c-akt -- genetics KW - Animals KW - Mitogen-Activated Protein Kinase 3 -- genetics KW - Humans KW - Transcription, Genetic KW - RNA, Small Interfering -- metabolism KW - Epithelial Cells -- cytology KW - Herpesvirus 4, Human -- genetics KW - Protein Kinases -- genetics KW - Gene Expression Regulation KW - Epstein-Barr Virus Infections KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Epithelial Cells -- physiology KW - Herpesvirus 4, Human -- metabolism KW - Transcription Factor RelA -- metabolism KW - RNA, Small Interfering -- genetics KW - Antigens, CD40 -- metabolism KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Protein Kinases -- metabolism KW - Signal Transduction -- physiology KW - Transcription Factor RelA -- genetics KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Cell Line KW - Viral Matrix Proteins -- genetics KW - Promoter Regions, Genetic KW - B-Lymphocytes -- virology KW - Telomerase -- genetics KW - B-Lymphocytes -- enzymology KW - Telomerase -- metabolism KW - B-Lymphocytes -- physiology KW - Viral Matrix Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69618824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Latent+membrane+protein+1+of+Epstein-Barr+virus+activates+the+hTERT+promoter+and+enhances+telomerase+activity+in+B+lymphocytes.&rft.au=Terrin%2C+Liliana%3BDal+Col%2C+Jessica%3BRampazzo%2C+Enrica%3BZancai%2C+Paola%3BPedrotti%2C+Moreno%3BAmmirabile%2C+Grazia%3BBergamin%2C+Stefano%3BRizzo%2C+Silvana%3BDolcetti%2C+Riccardo%3BDe+Rossi%2C+Anita&rft.aulast=Terrin&rft.aufirst=Liliana&rft.date=2008-10-01&rft.volume=82&rft.issue=20&rft.spage=10175&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00321-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-14 N1 - Date created - 2008-09-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2007 Apr 6;355(2):379-84 [17307151] Int J Cancer. 2007 Aug 1;121(3):576-87 [17417773] Ann N Y Acad Sci. 2007 Oct;1114:36-47 [17986575] J Virol. 1995 Apr;69(4):2168-74 [7884865] Nature. 1996 Mar 7;380(6569):79-82 [8598912] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12606-11 [12193655] Virology. 2002 Oct 25;302(2):310-20 [12441075] Cancer Res. 2003 Jan 1;63(1):18-21 [12517770] J Biol Chem. 2003 Feb 7;278(6):3694-704 [12446712] J Cell Physiol. 2003 Aug;196(2):207-18 [12811813] Virology. 1996 Sep 1;223(1):29-40 [8806537] Blood. 1997 Feb 15;89(4):1299-307 [9028953] Blood. 1997 Jul 1;90(1):313-22 [9207467] Science. 1997 Aug 15;277(5328):955-9 [9252327] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10827-32 [9380719] Eur J Immunol. 1999 Nov;29(11):3745-53 [10556831] Oncogene. 1999 Nov 22;18(49):6959-64 [10602470] Mol Cell Biol. 2000 Mar;20(5):1626-38 [10669740] Int J Cancer. 2000 May 1;86(3):375-84 [10760826] J Biol Chem. 2000 Aug 4;275(31):23814-24 [10781614] J Biol Chem. 2000 Nov 24;275(47):36671-5 [10970902] J Infect Dis. 2001 Feb 1;183(3):417-24 [11133373] Int J Cancer. 2001 Mar 1;91(5):644-9 [11267974] J Virol. 2001 May;75(9):4467-72 [11287602] Blood. 2001 Aug 1;98(3):597-603 [11468156] Semin Cancer Biol. 2001 Dec;11(6):435-44 [11669605] AIDS. 2002 Jan 4;16(1):63-73 [11741164] Oncogene. 2002 Jun 13;21(26):4071-9 [12037663] Oncogene. 2002 May 9;21(20):3130-8 [12082628] Am J Pathol. 2002 Jul;161(1):163-71 [12107101] Mol Cancer Ther. 2003 Aug;2(8):789-95 [12939469] Oncogene. 2003 Nov 13;22(51):8263-70 [14614450] J Biol Chem. 2003 Dec 19;278(51):51134-42 [14532284] Mol Cell Biol. 2004 Jan;24(1):25-35 [14673140] Mol Cell Biol. 2004 Jan;24(1):192-9 [14673155] FEBS Lett. 2004 Apr 23;564(1-2):9-13 [15094035] Cancer Res. 2004 May 15;64(10):3361-4 [15150084] Oncogene. 2004 Jun 3;23(26):4505-15 [15048073] J Virol. 2004 Oct;78(19):10348-59 [15367601] Blood. 2004 Oct 15;104(8):2523-31 [15226182] Int J Cancer. 1987 Aug 15;40(2):202-6 [3038758] Cell. 1995 Feb 10;80(3):389-99 [7859281] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12592-7 [9356494] Virology. 1998 Jan 5;240(1):93-9 [9448693] J Biol Chem. 1998 Feb 6;273(6):3285-90 [9452444] Nat Genet. 1999 Feb;21(2):220-4 [9988278] J Immunol. 1999 Mar 15;162(6):3298-307 [10092782] J Biol Chem. 1999 May 7;274(19):13085-90 [10224060] EMBO J. 1999 May 4;18(9):2511-21 [10228165] J Biol Chem. 1999 Jun 4;274(23):16085-96 [10347160] EMBO J. 1999 Jun 1;18(11):3064-73 [10357818] Mol Cell Biol. 1999 Jul;19(7):4798-805 [10373529] Br J Haematol. 1999 Sep;106(3):662-8 [10468854] Nature. 1999 Sep 2;401(6748):82-5 [10485710] Nature. 1999 Sep 2;401(6748):86-90 [10485711] Nat Med. 1999 Oct;5(10):1164-70 [10502820] Science. 1999 Oct 8;286(5438):300-3 [10514374] Gene. 2004 Sep 29;340(1):1-10 [15556289] J Exp Clin Cancer Res. 2004 Sep;23(3):495-506 [15595642] Oncogene. 2005 Feb 17;24(8):1320-7 [15608686] J Immunol. 2005 May 1;174(9):5261-9 [15843522] Int J Biochem Cell Biol. 2005 Sep;37(9):1881-9 [15967702] Cell Death Differ. 2005 Nov;12(11):1429-38 [15920535] Mol Cell Biol. 2006 Jan;26(1):230-7 [16354694] Gynecol Oncol. 2006 Mar;100(3):487-94 [16249016] Gynecol Oncol. 2006 May;101(2):305-10 [16380156] Oncogene. 2006 Aug 3;25(33):4505-14 [16619047] Expert Opin Biol Ther. 2006 Nov;6(11):1193-205 [17049016] FEBS Lett. 2006 Dec 22;580(30):6819-24 [17141225] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00321-08 ER - TY - JOUR T1 - Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. AN - 69618157; 18676680 AB - Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with lung cancer in a population-based case-control study in Xuan Wei, China (122 cases and 111 controls). A total of 1260 single-nucleotide polymorphisms (SNPs) in 380 candidate genes for lung cancer were successfully genotyped and assigned to one of 10 pathways based on gene ontology. Logistic regression was used to assess the marginal effect of each SNP on lung cancer susceptibility. The minP test was used to identify statistically significant associations at the gene level. Important pathways were identified using a test of proportions and the rank truncated product methods. The cell cycle pathway was found as the most important pathway (P = 0.044) with four genes significantly associated with lung cancer (PLA2G6 minP = 0.001, CCNA2 minP = 0.006, GSK3 beta minP = 0.007 and EGF minP = 0.013), after adjusting for multiple comparisons. Interestingly, most cell cycle genes that were associated with lung cancer in this analysis were concentrated in the AKT signaling pathway, which is essential for regulation of cell cycle progression and cellular survival, and may be important in lung cancer etiology in Xuan Wei. These results should be viewed as exploratory until they are replicated in a larger study. JF - Carcinogenesis AU - Hosgood, H Dean AU - Menashe, Idan AU - Shen, Min AU - Yeager, Meredith AU - Yuenger, Jeff AU - Rajaraman, Preetha AU - He, Xingzhou AU - Chatterjee, Nilanjan AU - Caporaso, Neil E AU - Zhu, Yong AU - Chanock, Stephen J AU - Zheng, Tongzhang AU - Lan, Qing AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. hosgoodd@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1938 EP - 1943 VL - 29 IS - 10 KW - Epidermal Growth Factor KW - 62229-50-9 KW - Glycogen Synthase Kinase 3 beta KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins c-akt KW - Glycogen Synthase Kinase 3 KW - EC 2.7.11.26 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Aged KW - Epidermal Growth Factor -- genetics KW - Genotype KW - Glycogen Synthase Kinase 3 -- genetics KW - Logistic Models KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Proto-Oncogene Proteins c-akt -- physiology KW - Female KW - Male KW - Signal Transduction -- physiology KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Cell Cycle KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69618157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Pathway-based+evaluation+of+380+candidate+genes+and+lung+cancer+susceptibility+suggests+the+importance+of+the+cell+cycle+pathway.&rft.au=Hosgood%2C+H+Dean%3BMenashe%2C+Idan%3BShen%2C+Min%3BYeager%2C+Meredith%3BYuenger%2C+Jeff%3BRajaraman%2C+Preetha%3BHe%2C+Xingzhou%3BChatterjee%2C+Nilanjan%3BCaporaso%2C+Neil+E%3BZhu%2C+Yong%3BChanock%2C+Stephen+J%3BZheng%2C+Tongzhang%3BLan%2C+Qing&rft.aulast=Hosgood&rft.aufirst=H&rft.date=2008-10-01&rft.volume=29&rft.issue=10&rft.spage=1938&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn178 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-14 N1 - Date created - 2008-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurosci Lett. 2005 Feb 21;374(3):157-60 [15663953] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Respirology. 2007 Nov;12(6):902-5 [17986122] Genet Epidemiol. 2007 Dec;31(8):803-12 [17549762] PLoS One. 2008;3(2):e1651 [18297132] Int J Cancer. 2008 Nov 1;123(9):2164-9 [18712724] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Exp Cell Res. 1999 Nov 25;253(1):210-29 [10579924] Cancer Epidemiol Biomarkers Prev. 2000 Jun;9(6):605-8 [10868696] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Int J Cancer. 2005 Sep 20;116(5):768-73 [15849729] Biochem Biophys Res Commun. 2005 Sep 9;334(4):1365-73 [16043125] Food Chem Toxicol. 2006 Sep;44(9):1590-6 [16750592] Genet Epidemiol. 2006 Sep;30(6):495-507 [16755536] Clin Cancer Res. 2006 Sep 1;12(17):5074-81 [16951223] Circulation. 2006 Oct 3;114(14):1545-8 [17015806] Lancet Oncol. 2006 Dec;7(12):977-8 [17348122] BMC Genomics. 2007;8:297 [17727719] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] J Natl Cancer Inst. 2002 Jun 5;94(11):826-35 [12048270] APMIS. 2002 Aug;110(7-8):587-92 [12390418] Genet Epidemiol. 2003 Dec;25(4):360-6 [14639705] Oncogene. 2003 Dec 8;22(56):8983-98 [14663477] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] Toxicology. 2004 May 20;198(1-3):301-5 [15138056] Science. 1987 Jan 9;235(4785):217-20 [3798109] Arch Environ Health. 1988 Mar-Apr;43(2):180-5 [3377554] Tumour Biol. 1990;11(5):229-61 [2203137] Cancer Res. 1990 Nov 1;50(21):7077-80 [2208175] Anticancer Res. 1992 Jul-Aug;12(4):1183-7 [1503407] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Carcinogenesis. 1995 Dec;16(12):3031-6 [8603481] Cell Signal. 1998 Apr;10(4):233-9 [9617480] Carcinogenesis. 2004 Nov;25(11):2177-81 [15284179] Anticancer Res. 2007 Sep-Oct;27(5B):3561-9 [17972518] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn178 ER - TY - JOUR T1 - Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. AN - 69615177; 18710938 AB - Oct4 and Sox2 are transcription factors required for pluripotency during early embryogenesis and for the maintenance of embryonic stem cell (ESC) identity. Functional mechanisms contributing to pluripotency are expected to be associated with genes transcriptionally activated by these factors. Here, we show that Oct4 and Sox2 bind to a conserved promoter region of miR-302, a cluster of eight microRNAs expressed specifically in ESCs and pluripotent cells. The expression of miR-302a is dependent on Oct4/Sox2 in human ESCs (hESCs), and miR-302a is expressed at the same developmental stages and in the same tissues as Oct4 during embryogenesis. miR-302a is predicted to target many cell cycle regulators, and the expression of miR-302a in primary and transformed cell lines promotes an increase in S-phase and a decrease in G(1)-phase cells, reminiscent of an ESC-like cell cycle profile. Correspondingly, the inhibition of miR-302 causes hESCs to accumulate in G(1) phase. Moreover, we show that miR-302a represses the productive translation of an important G(1) regulator, cyclin D1, in hESCs. The transcriptional activation of miR-302 and the translational repression of its targets, such as cyclin D1, may provide a link between Oct4/Sox2 and cell cycle regulation in pluripotent cells. JF - Molecular and cellular biology AU - Card, Deborah A Greer AU - Hebbar, Pratibha B AU - Li, Leping AU - Trotter, Kevin W AU - Komatsu, Yoshihiro AU - Mishina, Yuji AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 6426 EP - 6438 VL - 28 IS - 20 KW - DNA-Binding Proteins KW - 0 KW - HMGB Proteins KW - Homeodomain Proteins KW - MIRN302 microRNA, human KW - MicroRNAs KW - NANOG protein, human KW - Nanog Homeobox Protein KW - Octamer Transcription Factor-3 KW - SOX2 protein, human KW - SOXB1 Transcription Factors KW - Sox2 protein, mouse KW - Transcription Factors KW - Cyclin D1 KW - 136601-57-5 KW - CDK4 protein, human KW - EC 2.7.11.22 KW - Cyclin-Dependent Kinase 4 KW - Index Medicus KW - Embryonic Development KW - Animals KW - Humans KW - Transcription, Genetic KW - Mice KW - Protein Binding KW - Cyclin-Dependent Kinase 4 -- metabolism KW - Base Sequence KW - Homeodomain Proteins -- metabolism KW - Molecular Sequence Data KW - Promoter Regions, Genetic -- genetics KW - G1 Phase KW - Cell Line KW - Gene Expression Regulation, Developmental KW - Transcription Factors -- metabolism KW - HMGB Proteins -- metabolism KW - MicroRNAs -- genetics KW - DNA-Binding Proteins -- genetics KW - HMGB Proteins -- genetics KW - Transcription Factors -- genetics KW - Embryonic Stem Cells -- enzymology KW - Embryonic Stem Cells -- metabolism KW - Cyclin D1 -- metabolism KW - MicroRNAs -- metabolism KW - Octamer Transcription Factor-3 -- genetics KW - Octamer Transcription Factor-3 -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69615177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Oct4%2FSox2-regulated+miR-302+targets+cyclin+D1+in+human+embryonic+stem+cells.&rft.au=Card%2C+Deborah+A+Greer%3BHebbar%2C+Pratibha+B%3BLi%2C+Leping%3BTrotter%2C+Kevin+W%3BKomatsu%2C+Yoshihiro%3BMishina%2C+Yuji%3BArcher%2C+Trevor+K&rft.aulast=Card&rft.aufirst=Deborah+A&rft.date=2008-10-01&rft.volume=28&rft.issue=20&rft.spage=6426&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.00359-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-24 N1 - Date created - 2008-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Dec 15;59(24):6087-90 [10626795] Mol Cell Biol. 2007 Mar;27(6):2240-52 [17242205] Development. 2002 Feb;129(4):905-16 [11861474] Oncogene. 2002 Aug 15;21(36):5515-28 [12165850] Science. 2002 Sep 20;297(5589):2053-6 [12242443] Mol Cell Biol. 2003 Apr;23(8):2699-708 [12665572] Cell. 2003 May 30;113(5):631-42 [12787504] Mol Cell Biol. 2003 Aug;23(16):5867-81 [12897156] Dev Cell. 2003 Aug;5(2):351-8 [12919684] Genes Dev. 2003 Aug 15;17(16):2048-59 [12923055] Cell. 2003 Dec 26;115(7):787-98 [14697198] Cell. 2004 Jan 23;116(2):281-97 [14744438] Dev Biol. 2004 Jun 15;270(2):488-98 [15183728] EMBO J. 2004 Oct 13;23(20):4051-60 [15372072] Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 [6828386] Gene. 1991 Dec 15;108(2):193-9 [1660837] Oncogene. 1994 Mar;9(3):809-18 [8108123] Genes Dev. 1995 Nov 1;9(21):2635-45 [7590241] Nucleic Acids Res. 1995 Dec 11;23(23):4878-84 [8532532] Oncogene. 1996 Jan 18;12(2):309-22 [8570208] J Comput Biol. 1994 Fall;1(3):191-8 [8790464] Cell. 1998 Oct 30;95(3):379-91 [9814708] Mol Cell Biol. 1999 Aug;19(8):5453-65 [10409735] RNA. 2004 Dec;10(12):1957-66 [15525708] Cell. 2005 Jan 14;120(1):15-20 [15652477] J Biol Chem. 2005 Feb 18;280(7):5307-17 [15557334] Science. 2005 May 6;308(5723):833-8 [15774722] Nature. 2005 Jun 9;435(7043):839-43 [15944709] Nature. 2005 Jun 16;435(7044):974-8 [15944714] J Biol Chem. 2005 Jul 1;280(26):24731-7 [15860457] Mol Cell Biol. 2005 Jul;25(14):6031-46 [15988017] Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12135-40 [16099834] Cell. 2005 Sep 23;122(6):947-56 [16153702] Cell. 2005 Dec 2;123(5):819-31 [16325577] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2422-7 [16461918] Nat Genet. 2006 Apr;38(4):431-40 [16518401] Stem Cells. 2006 Mar;24(3):547-56 [16239321] Science. 2006 Apr 7;312(5770):75-9 [16484454] Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8721-6 [16731620] Cell. 2006 Aug 25;126(4):663-76 [16904174] Cell. 2006 Sep 22;126(6):1203-17 [16990141] Dev Cell. 2001 Sep;1(3):377-87 [11702949] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.00359-08 ER - TY - JOUR T1 - Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. AN - 69601554; 18817471 AB - Nanoparticles possess enormous potential as diagnostic imaging agents and hold promise for the development of multimodality agents with both imaging and therapeutic capabilities. Yet, some of the most promising nanoparticles demonstrate prolonged tissue retention and contain heavy metals. This presents serious concerns for toxicity. The creation of nanoparticles with optimal clearance characteristics will minimize toxicity risks by reducing the duration of exposure to these agents. Given that many nanoparticles possess easily modifiable surface and interior chemistry, if nanoparticle characteristics associated with optimal clearance from the body were well established, it would be feasible to design and create agents with more favorable clearance properties. This article presents a thorough discussion of the physiologic aspects of nanoparticle clearance, focusing on renal mechanisms, and provides an overview of current research investigating clearance of specific types of nanoparticles and nano-sized macromolecules, including dendrimers, quantum dots, liposomes and carbon, gold and silica-based nanoparticles. JF - Nanomedicine (London, England) AU - Longmire, Michelle AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, NCI/NIH Building 10, Bethesda, MD 20892-1088, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 703 EP - 717 VL - 3 IS - 5 KW - Biocompatible Materials KW - 0 KW - Dendrimers KW - Liposomes KW - Nanotubes, Carbon KW - Polymers KW - Gold KW - 7440-57-5 KW - Silicon Dioxide KW - 7631-86-9 KW - Index Medicus KW - Biocompatible Materials -- chemistry KW - Quantum Dots KW - Nanotubes, Carbon -- chemistry KW - Magnetic Resonance Imaging -- methods KW - Particle Size KW - Humans KW - Liver -- metabolism KW - Polymers -- chemistry KW - Liposomes -- chemistry KW - Gold -- chemistry KW - Silicon Dioxide -- chemistry KW - Kidney -- pathology KW - Diagnostic Imaging -- instrumentation KW - Metal Nanoparticles -- chemistry KW - Diagnostic Imaging -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69601554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine+%28London%2C+England%29&rft.atitle=Clearance+properties+of+nano-sized+particles+and+molecules+as+imaging+agents%3A+considerations+and+caveats.&rft.au=Longmire%2C+Michelle%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Longmire&rft.aufirst=Michelle&rft.date=2008-10-01&rft.volume=3&rft.issue=5&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Nanomedicine+%28London%2C+England%29&rft.issn=1748-6963&rft_id=info:doi/10.2217%2F17435889.3.5.703 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-09-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Chem Soc. 2008 Feb 20;130(7):2154-5 [18217764] Biomaterials. 2008 Apr;29(12):1912-9 [18242692] Environ Health Perspect. 2007 Sep;115(9):1339-43 [17805425] Nat Biotechnol. 2007 Oct;25(10):1165-70 [17891134] Expert Opin Drug Deliv. 2007 Nov;4(6):621-33 [17970665] Regul Toxicol Pharmacol. 2007 Dec;49(3):217-29 [17868963] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1410-5 [18230737] Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L843-54 [17693486] Mol Pharm. 2008 Mar-Apr;5(2):316-27 [18217714] J Control Release. 2000 Mar 1;65(1-2):133-48 [10699277] Cancer Res. 2000 Dec 15;60(24):6964-71 [11156397] Am J Physiol Renal Physiol. 2001 Mar;280(3):F396-405 [11181401] Magn Reson Med. 2001 Mar;45(3):454-60 [11241704] Am J Physiol Renal Physiol. 2001 Oct;281(4):F579-96 [11553505] Biophys J. 2001 Oct;81(4):1930-7 [11566767] Radiol Clin North Am. 2001 Sep;39(5):947-56, viii [11587063] Magn Reson Med. 2001 Dec;46(6):1169-73 [11746584] Biosci Rep. 2002 Apr;22(2):197-224 [12428901] Bioconjug Chem. 2003 Mar-Apr;14(2):388-94 [12643749] J Am Chem Soc. 2003 May 7;125(18):5471-8 [12720461] Magn Reson Med. 2004 Jan;51(1):27-34 [14705042] Bioconjug Chem. 2004 Jan-Feb;15(1):79-86 [14733586] Cell Tissue Res. 2004 Jun;316(3):315-23 [15103550] J Magn Reson Imaging. 2004 Sep;20(3):512-8 [15332261] Annu Rev Biophys Bioeng. 1980;9:467-508 [6994593] Crit Rev Ther Drug Carrier Syst. 1987;3(2):123-93 [3542245] Scand J Clin Lab Invest. 1990 Nov;50(7):757-61 [2293336] J Immunol. 1991 Jun 15;146(12):4234-41 [2040798] Eur J Clin Pharmacol. 1991;40(6):619-24 [1884745] Biochim Biophys Acta. 1992 Jan 31;1103(2):198-204 [1543704] Invest Radiol. 1992 Aug;27 Suppl 1:S12-5 [1506147] J Biol Chem. 1992 Sep 15;267(26):18759-65 [1527006] Magn Reson Med. 1994 Jan;31(1):1-8 [8121264] Pharm Res. 1994 Mar;11(3):402-6 [8008707] Cancer Res. 1996 Aug 15;56(16):3788-95 [8706025] Acad Radiol. 1996 Aug;3 Suppl 2:S292-4 [8796583] J Microencapsul. 1996 May-Jun;13(3):245-55 [8860681] Pharm Res. 1996 Nov;13(11):1704-9 [8956338] Invest Radiol. 1998 Sep;33(9):699-708 [9766055] J Drug Target. 1998;6(3):167-74 [9888302] Bioconjug Chem. 1999 Jan-Feb;10(1):103-11 [9893971] Cancer Res. 1999 Jan 15;59(2):422-30 [9927057] J Magn Reson Imaging. 1999 Feb;9(2):348-52 [10077036] Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5182-7 [10220440] Nat Biotechnol. 1999 Aug;17(8):780-3 [10429243] Curr Pharm Biotechnol. 2004 Dec;5(6):539-49 [15579043] J Am Chem Soc. 2005 Jan 19;127(2):799-805 [15643906] Nano Lett. 2005 Mar;5(3):473-7 [15755097] Magn Reson Med. 2005 Apr;53(4):835-42 [15799038] Adv Drug Deliv Rev. 2005 Dec 14;57(15):2271-86 [16290152] Environ Health Perspect. 2006 Feb;114(2):165-72 [16451849] Invest Radiol. 2006 Mar;41(3):313-24 [16481915] Br J Radiol. 2006 Mar;79(939):248-53 [16498039] Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3357-62 [16492781] Ann Biomed Eng. 2006 Jan;34(1):15-22 [16528617] Anal Bioanal Chem. 2006 Jun;385(3):518-24 [16715275] Radiology. 2006 Sep;240(3):756-64 [16837672] Drug Deliv. 2006 Nov-Dec;13(6):399-409 [17002967] Pharm Res. 2006 Aug;23(8):1736-42 [16850267] Adv Drug Deliv Rev. 2006 Dec 1;58(14):1471-504 [17116343] Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18882-6 [17135351] Contrast Media Mol Imaging. 2006 Nov-Dec;1(6):230-45 [17191764] Biochem Soc Trans. 2007 Feb;35(Pt 1):61-7 [17233602] Curr Opin Biotechnol. 2007 Feb;18(1):17-25 [17234399] Expert Opin Drug Deliv. 2007 Mar;4(2):149-64 [17335412] Bioconjug Chem. 2007 Mar-Apr;18(2):389-96 [17263568] Small. 2007 Feb;3(2):333-41 [17262759] Pharm Res. 2007 Jun;24(6):1193-201 [17373581] Contrast Media Mol Imaging. 2007 May-Jun;2(3):139-46 [17583898] J Nucl Med. 2007 Sep;48(9):1511-8 [17704240] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2217/17435889.3.5.703 ER - TY - JOUR T1 - Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. AN - 69595366; 18787106 AB - Radiation, a primary mode of cancer therapy, acutely damages cellular macromolecules and DNA and elicits stress responses that lead to cell death. The known cytoprotective activity of nitric oxide (NO) is blocked by thrombospondin-1, a potent antagonist of NO/cGMP signaling in ischemic soft tissues, suggesting that thrombospondin-1 signaling via its receptor CD47 could correspondingly increase radiosensitivity. We show here that soft tissues in thrombospondin-1-null mice are remarkably resistant to radiation injury. Twelve hours after 25-Gy hindlimb irradiation, thrombospondin-1-null mice showed significantly less cell death in both muscle and bone marrow. Two months after irradiation, skin and muscle units in null mice showed minimal histological evidence of radiation injury and near full retention of mitochondrial function. Additionally, both tissue perfusion and acute vascular responses to NO were preserved in irradiated thrombospondin-1-null hindlimbs. The role of thrombospondin-1 in radiosensitization is specific because thrombospondin-2-null mice were not protected. However, mice lacking CD47 showed radioresistance similar to thrombospondin-1-null mice. Both thrombospondin-1- and CD47-dependent radiosensitization is cell autonomous because vascular cells isolated from the respective null mice showed dramatically increased survival and improved proliferative capacity after irradiation in vitro. Therefore, thrombospondin-1/CD47 antagonists may have selective radioprotective activity for normal tissues. JF - The American journal of pathology AU - Isenberg, Jeff S AU - Maxhimer, Justin B AU - Hyodo, Fuminori AU - Pendrak, Michael L AU - Ridnour, Lisa A AU - DeGraff, William G AU - Tsokos, Maria AU - Wink, David A AU - Roberts, David D AD - Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1500, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1100 EP - 1112 VL - 173 IS - 4 KW - Antigens, CD47 KW - 0 KW - Thrombospondin 1 KW - Thrombospondins KW - thrombospondin 2 KW - Abridged Index Medicus KW - Index Medicus KW - Endothelial Cells -- radiation effects KW - Animals KW - Radiation Tolerance -- radiation effects KW - Cell Proliferation -- radiation effects KW - Apoptosis -- radiation effects KW - Mice KW - Thrombospondins -- metabolism KW - Blood Vessels -- pathology KW - Neoplasm Transplantation KW - X-Rays KW - Hypertrophy KW - Neoplasms -- pathology KW - Cells, Cultured KW - Blood Vessels -- radiation effects KW - Hindlimb -- radiation effects KW - Mice, Inbred C57BL KW - Cell Survival -- radiation effects KW - Endothelial Cells -- pathology KW - Hindlimb -- pathology KW - Male KW - Radiation Injuries, Experimental -- pathology KW - Radiation Injuries, Experimental -- metabolism KW - Antigens, CD47 -- metabolism KW - Thrombospondin 1 -- metabolism KW - Tissue Survival -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69595366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Thrombospondin-1+and+CD47+limit+cell+and+tissue+survival+of+radiation+injury.&rft.au=Isenberg%2C+Jeff+S%3BMaxhimer%2C+Justin+B%3BHyodo%2C+Fuminori%3BPendrak%2C+Michael+L%3BRidnour%2C+Lisa+A%3BDeGraff%2C+William+G%3BTsokos%2C+Maria%3BWink%2C+David+A%3BRoberts%2C+David+D&rft.aulast=Isenberg&rft.aufirst=Jeff&rft.date=2008-10-01&rft.volume=173&rft.issue=4&rft.spage=1100&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=1525-2191&rft_id=info:doi/10.2353%2Fajpath.2008.080237 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-08 N1 - Date created - 2008-09-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13141-6 [16150726] Lancet Oncol. 2005 Jul;6(7):520-8 [15992701] Oncogene. 2006 Jun 29;25(28):3885-93 [16462761] Cardiovasc Res. 2006 Sep 1;71(4):785-93 [16820142] J Biol Chem. 2006 Sep 8;281(36):26069-80 [16835222] Exp Hematol. 2007 Jan;35(1):137-45 [17198882] Blood. 2007 Mar 1;109(5):1945-52 [17082319] Circ Res. 2007 Mar 16;100(5):712-20 [17293482] Semin Radiat Oncol. 2007 Apr;17(2):81-8 [17395038] Semin Radiat Oncol. 2007 Apr;17(2):121-30 [17395042] J Immunol. 2007 May 1;178(9):5930-9 [17442977] Biol Pharm Bull. 2007 Jun;30(6):1102-7 [17541161] Front Radiat Ther Oncol. 2007;40:18-39 [17641500] Clin Cancer Res. 2007 Aug 15;13(16):4928-33 [17699873] Am J Pathol. 2007 Sep;171(3):777-89 [17640965] Mol Cell Biol. 2007 Oct;27(20):7073-88 [17682056] Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2582-8 [17916772] Mol Cancer Res. 2007 Dec;5(12):1225-31 [18171979] Cell Mol Life Sci. 2008 Mar;65(5):672-86 [18193164] Neoplasia. 2008 Aug;10(8):886-96 [18670646] J Biol Chem. 2005 Aug 19;280(33):29637-44 [15917238] Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):59-69 [10708953] Am J Pathol. 2001 Nov;159(5):1949-56 [11696456] Curr Probl Cancer. 2001 Nov-Dec;25(6):334-411 [11740469] Am J Pathol. 2002 Mar;160(3):1057-68 [11891202] J Biol Chem. 2002 May 3;277(18):15400-6 [11856735] J Cell Biol. 2002 Apr 29;157(3):509-19 [11980922] EMBO J. 2002 Oct 1;21(19):5195-205 [12356735] J Invest Dermatol. 2003 Jan;120(1):14-9 [12535193] Int J Radiat Biol. 2003 Feb;79(2):71-81 [12569011] Cell Biol Toxicol. 2003 Feb;19(1):13-27 [12661984] Cancer Res. 2003 Jul 15;63(14):4055-61 [12874006] Oncogene. 2003 Sep 1;22(37):5866-75 [12947393] Am J Pathol. 2003 Dec;163(6):2247-57 [14633599] Dev Dyn. 2003 Dec;228(4):630-42 [14648840] Gut. 2004 Feb;53(2):214-21 [14724153] Life Sci. 2004 May 7;74(25):3055-63 [15081571] Int J Biochem Cell Biol. 2004 Jun;36(6):1115-25 [15094126] Oncogene. 2004 Apr 22;23(19):3265-71 [15064735] FEBS Lett. 2004 Jul 30;571(1-3):227-32 [15280047] Cancer Res. 1994 Jul 1;54(13):3365-8 [7516820] Cancer Res. 1994 Dec 15;54(24):6504-11 [7527299] J Biol Chem. 1996 Jan 5;271(1):21-4 [8550562] Science. 1996 Nov 1;274(5288):795-8 [8864123] J Clin Invest. 1998 Mar 1;101(5):982-92 [9486968] Cell. 1998 Jun 26;93(7):1159-70 [9657149] Cancer Res. 2004 Nov 1;64(21):8015-21 [15520210] Radiat Res. 2006 Jun;165(6):671-7 [16802867] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2353/ajpath.2008.080237 ER - TY - JOUR T1 - The metabolism of proline as microenvironmental stress substrate. AN - 69586045; 18806116 AB - Proline, a unique proteogenic secondary amino acid, has its own metabolic system with special features. Recent findings defining the regulation of this system led us to propose that proline is a stress substrate in the microenvironment of inflammation and tumorigenesis. The criteria for proline as a stress substrate are: 1) the enzymes utilizing proline respond to stress signaling; 2) there is a large, mobilizable pool of proline; and 3) the metabolism of proline serves special stress functions. Studies show that the proline-utilizing enzyme, proline oxidase (POX)/proline dehydrogenase (PRODH), responds to genotoxic, inflammatory, and nutrient stress. Proline as substrate is stored as collagen in extracellular matrix, connective tissue, and bone and it is rapidly released from this reservoir by the sequential action of matrix metalloproteinases, peptidases, and prolidase. Special functions include the use of proline by POX/PRODH to generate superoxide radicals that initiate apoptosis by intrinsic and extrinsic pathways. Under conditions of nutrient stress, proline is an energy source. It provides carbons for the tricarboxylic acid cycle and also participates in the proline cycle. The latter, catalyzed by mitochondrial POX and cytosolic pyrroline-5-carboxylate reductase, shuttles reducing potential from the pentose phosphate pathway into mitochondria to generate ATP and oxidizing potential to activate the cytosolic pentose phosphate pathway. JF - The Journal of nutrition AU - Phang, James M AU - Pandhare, Jui AU - Liu, Yongmin AD - Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA. phang@mail.ncifcrf.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 2008S EP - 2015S VL - 138 IS - 10 KW - Dietary Proteins KW - 0 KW - Collagen KW - 9007-34-5 KW - Proline KW - 9DLQ4CIU6V KW - Pyrroline Carboxylate Reductases KW - EC 1.5.1.- KW - delta-1-pyrroline-5-carboxylate reductase KW - EC 1.5.1.2 KW - Proline Oxidase KW - EC 1.5.3.- KW - Index Medicus KW - Pyrroline Carboxylate Reductases -- metabolism KW - Inflammation -- physiopathology KW - Dietary Proteins -- metabolism KW - Collagen -- metabolism KW - Humans KW - Proline Oxidase -- metabolism KW - Neoplasms -- physiopathology KW - Homeostasis KW - Stress, Physiological KW - Proline -- metabolism KW - Food KW - Proline -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69586045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=The+metabolism+of+proline+as+microenvironmental+stress+substrate.&rft.au=Phang%2C+James+M%3BPandhare%2C+Jui%3BLiu%2C+Yongmin&rft.aulast=Phang&rft.aufirst=James&rft.date=2008-10-01&rft.volume=138&rft.issue=10&rft.spage=2008S&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=1541-6100&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-02 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13009-14 [11069295] Biochem J. 1982 Apr 15;204(1):313-21 [6810880] J Biol Chem. 2002 Feb 8;277(6):4223-31 [11704682] Br J Nutr. 2002 Jan;87 Suppl 1:S17-21 [11895151] J Biol Chem. 2003 Mar 14;278(11):9784-9 [12514185] Am J Clin Nutr. 2003 Nov;78(5):979-84 [14594785] Cancer Metastasis Rev. 2004 Jan-Jun;23(1-2):119-35 [15000153] Herz. 2004 Mar;29(2):162-6 [15054588] Nat Rev Immunol. 2004 Aug;4(8):617-29 [15286728] Biochim Biophys Acta. 2004 Sep 1;1701(1-2):49-59 [15450175] J Nutr. 2004 Oct;134(10 Suppl):2863S-2867S; discussion 2895S [15465802] J Clin Invest. 1967 Jul;46(7):1172-7 [6027080] Science. 1970 Feb 13;167(3920):1003-4 [5411169] Int Rev Connect Tissue Res. 1970;5:1-91 [5500436] Eur J Biochem. 1977 Dec;81(3):599-607 [598383] Biochem Biophys Res Commun. 1980 Mar 28;93(2):462-70 [6892988] Annu Rev Biochem. 1980;49:1005-61 [6250440] Arch Biochem Biophys. 1983 Aug;225(1):95-101 [6688511] Carcinogenesis. 1985 Apr;6(4):501-4 [3986956] Curr Top Cell Regul. 1985;25:91-132 [2410198] Arch Biochem Biophys. 1986 Jul;248(1):166-74 [3729412] J Clin Endocrinol Metab. 1989 Aug;69(2):448-52 [2753984] Bone. 1989;10(6):439-45 [2624825] J Biol Chem. 1992 Jun 5;267(16):10931-4 [1375931] Cancer Res. 1994 May 1;54(9):2390-7 [8162586] Cancer Res. 1994 Sep 1;54(17):4726-8 [8062271] Digestion. 1994;55(4):229-33 [8063026] New Horiz. 1995 May;3(2):170-82 [7583159] Nature. 1997 Sep 18;389(6648):300-5 [9305847] Mol Carcinog. 1999 Jan;24(1):25-8 [10029407] Trends Biochem Sci. 1999 Feb;24(2):68-72 [10098401] J Biol Chem. 2005 Feb 25;280(8):6742-51 [15569667] Carcinogenesis. 2005 Aug;26(8):1335-42 [15817612] Curr Atheroscler Rep. 2005 Sep;7(5):369-74 [16105480] Nat Rev Immunol. 2005 Nov;5(11):844-52 [16239903] J Biol Chem. 2006 Jan 27;281(4):2044-52 [16303758] Diabetologia. 2006 Mar;49(3):434-41 [16477438] Crit Rev Clin Lab Sci. 2006;43(2):183-202 [16517422] Cancer Metastasis Rev. 2006 Mar;25(1):9-34 [16680569] Oncogene. 2006 Sep 14;25(41):5640-7 [16619034] Int J Cancer. 2006 Nov 15;119(10):2339-46 [16858678] Oncogene. 2006 Oct 16;25(48):6373-83 [17041623] J Biol Chem. 2006 Nov 3;281(44):33045-52 [16914544] Anticancer Drugs. 2007 Mar;18(3):237-44 [17264754] Nat Rev Mol Cell Biol. 2007 Mar;8(3):221-33 [17318226] J Biol Chem. 2007 May 11;282(19):14316-27 [17344208] Cells Tissues Organs. 2007;185(1-3):104-10 [17587815] Bioessays. 2007 Aug;29(8):738-44 [17621638] Semin Cancer Biol. 2007 Aug;17(4):309-16 [17651985] Shock. 2007 Aug;28(2):186-91 [17510607] Mol Pharmacol. 2007 Sep;72(3):674-85 [17535976] Nanomedicine (Lond). 2007 Feb;2(1):85-98 [17716195] Sci STKE. 2007 Oct 9;2007(407):cm8 [17925579] Trends Immunol. 2007 Dec;28(12):551-8 [17981503] Cancer Res. 2001 Mar 1;61(5):1810-5 [11280728] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of animal models to develop antiaddiction medications. AN - 69573892; 18803910 AB - Although addiction is a uniquely human phenomenon, some of its pathognomonic features can be modeled at the animal level. Such features include the euphoric "high" produced by acute administration of addictive drugs; the dysphoric "crash" produced by acute withdrawal; drug-seeking and drug-taking behaviors; and relapse to drug-seeking behavior after achieving successful abstinence. Animal models exist for each of these features. In this review, I focus on various animal models of addiction and how they can be used to search for clinically effective antiaddiction medications. I conclude by noting some of the new and novel medications that have been developed preclinically using such models and the hope for further developments along such lines. JF - Current psychiatry reports AU - Gardner, Eliot L AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA. egardner@intra.nida.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 377 EP - 384 VL - 10 IS - 5 KW - Dopamine Antagonists KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - GABA Agonists KW - GABA-B Receptor Agonists KW - Neurotransmitter Agents KW - Receptors, Dopamine D3 KW - Index Medicus KW - Animals KW - Motivation KW - Brain -- drug effects KW - Dopamine Antagonists -- pharmacology KW - Humans KW - Receptors, Dopamine D3 -- antagonists & inhibitors KW - Conditioning, Classical -- drug effects KW - Brain -- physiopathology KW - Nerve Net -- physiopathology KW - Neurotransmitter Agents -- metabolism KW - GABA Agonists -- pharmacology KW - Nerve Net -- drug effects KW - Secondary Prevention KW - Dopamine Plasma Membrane Transport Proteins -- antagonists & inhibitors KW - Substance-Related Disorders -- physiopathology KW - Disease Models, Animal KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69573892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=Use+of+animal+models+to+develop+antiaddiction+medications.&rft.au=Gardner%2C+Eliot+L&rft.aulast=Gardner&rft.aufirst=Eliot&rft.date=2008-10-01&rft.volume=10&rft.issue=5&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=1535-1645&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-27 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroimage. 2005 Jul 15;26(4):1097-108 [15886020] Drug Alcohol Depend. 2008 Oct 1;97(3):216-25 [18063319] J Pharmacol Exp Ther. 2000 Aug;294(2):613-9 [10900239] Am J Psychiatry. 2000 Nov;157(11):1789-98 [11058476] J Med Chem. 2000 Dec 28;43(26):4981-92 [11150168] Am J Addict. 2000 Fall;9(4):285-313 [11155784] Eur J Pharmacol. 2001 Mar 2;414(2-3):205-9 [11239920] Psychopharmacology (Berl). 2000 Dec;153(1):17-30 [11255926] Brain Res. 2001 Jul 20;908(1):86-92 [11457434] Psychopharmacology (Berl). 2002 Jan;159(2):125-32 [11862339] Pharmacol Rev. 2002 Mar;54(1):1-42 [11870259] Brain Res. 2002 Nov 1;954(1):132-40 [12393241] Neuropsychopharmacology. 2003 Mar;28(3):510-8 [12629530] Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20 [12402102] Synapse. 2003 Oct;50(1):1-6 [12872287] Synapse. 2003 Dec 1;50(3):261-5 [14515344] Psychopharmacology (Berl). 2005 Aug;181(1):90-100 [15739075] Neuropsychopharmacology. 2005 Nov;30(11):2065-72 [15841108] Psychopharmacology (Berl). 2006 May;185(4):459-70 [16555060] Int J Neuropsychopharmacol. 2006 Oct;9(5):585-602 [16942635] Neuropharmacology. 2006 Oct;51(5):993-1003 [16901516] Psychopharmacology (Berl). 2006 Nov;189(1):1-16 [17019567] CNS Drug Rev. 2007 Summer;13(2):240-59 [17627675] Addict Biol. 2007 Sep;12(3-4):227-462 [17678505] Psychopharmacology (Berl). 2007 Sep;194(1):117-25 [17558499] Nat Neurosci. 2004 Mar;7(3):211-4 [15001989] Neurosci Biobehav Rev. 2004 Jan;27(8):721-8 [15019422] J Neurosci. 2004 Jul 28;24(30):6686-92 [15282271] Psychopharmacology (Berl). 1977 Mar 16;51(3):235-42 [403538] Psychol Rev. 1981 May;88(3):228-73 [6264530] J Neurosci Methods. 1993 Jul;48(3):173-97 [8412302] Arch Gen Psychiatry. 1995 Jun;52(6):456-63 [7771915] Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12304-8 [8618890] J Neurosci Methods. 1996 May;66(1):1-11 [8794935] Psychopharmacology (Berl). 1997 Oct;133(4):383-8 [9372539] Prog Neurobiol. 1998 Dec;56(6):613-72 [9871940] J Pharmacol Exp Ther. 1999 Aug;290(2):797-802 [10411594] Eur J Pharmacol. 1999 Jun 30;375(1-3):13-30 [10443561] Nat Rev Neurosci. 2004 Dec;5(12):963-70 [15550951] Brain Res Brain Res Rev. 2005 Jul;49(1):77-105 [15960988] Addiction. 2007 Dec;102(12):1863-70 [18031422] Physiol Behav. 2005 Sep 15;86(1-2):18-20 [16061264] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Novel medications to treat addictive disorders. AN - 69571661; 18803912 AB - Recent discoveries about the effects of drugs of abuse on the brain and the mechanisms of their addictions; new chemical compounds, including immunotherapies; and new actions of available medications are offering many opportunities for the discovery and development of novel medications to treat addictive disorders. Furthermore, advancements in the understanding of the genetic and epigenetic basis of drug addiction and the pharmacogenetics of the safety and/or efficacy of the medications are providing opportunities for more individualized pharmacotherapy approaches. Although multiple medications have been investigated for treating addictions, only a handful have shown acceptable safety and efficacy and are approved by the US Food and Drug Administration. This article reviews the current medications that are medically safe and have shown promising results for treating opioid, cocaine, methamphetamine, and cannabis addictions. JF - Current psychiatry reports AU - Montoya, Iván D AU - Vocci, Frank AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, Room 4143, Bethesda, MD 20892-9551, USA. imontoya@nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 392 EP - 398 VL - 10 IS - 5 KW - Neurotransmitter Agents KW - 0 KW - Psychotropic Drugs KW - Street Drugs KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Neurotransmitter Agents -- metabolism KW - Substance Withdrawal Syndrome -- rehabilitation KW - Marijuana Abuse -- rehabilitation KW - Humans KW - Brain -- drug effects KW - Opioid-Related Disorders -- rehabilitation KW - Amphetamine-Related Disorders -- rehabilitation KW - Cocaine-Related Disorders -- rehabilitation KW - Methamphetamine -- toxicity KW - Psychotropic Drugs -- therapeutic use KW - Street Drugs -- toxicity KW - Psychotropic Drugs -- adverse effects KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69571661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=Novel+medications+to+treat+addictive+disorders.&rft.au=Montoya%2C+Iv%C3%A1n+D%3BVocci%2C+Frank&rft.aulast=Montoya&rft.aufirst=Iv%C3%A1n&rft.date=2008-10-01&rft.volume=10&rft.issue=5&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=1535-1645&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-27 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Neuropsychopharmacol. 2008 May;11(3):425-38 [17927843] Psychopharmacology (Berl). 2008 Mar;197(1):157-68 [18161012] Br J Pharmacol. 2008 May;154(2):327-42 [18345022] Addict Biol. 2008 Jun;13(2):188-95 [18279497] Drug Alcohol Depend. 2008 Aug 1;96(3):222-32 [18468815] Int J Neuropsychopharmacol. 2008 Sep;11(6):729-41 [18248689] J Subst Abuse Treat. 2008 Oct;35(3):334-42 [18329221] Vaccine. 2002 Jan 15;20(7-8):1196-204 [11803082] Addiction. 2003 Apr;98(4):427-39 [12653813] Drug Alcohol Depend. 2003 May 1;70(1):29-37 [12681523] J Subst Abuse Treat. 2003 Jun;24(4):369-76 [12867212] Drug Alcohol Depend. 2003 Nov 24;72(2):163-8 [14636971] Clin Pharmacol Ther. 2004 Jan;75(1):34-48 [14749690] Drug Alcohol Depend. 2004 Sep 6;75(3):233-40 [15283944] Addiction. 2004 Nov;99(11):1439-49 [15500597] Neuropsychopharmacology. 1995 Dec;13(4):269-93 [8747752] Neuropsychopharmacology. 2005 Jan;30(1):205-11 [15525998] Biol Psychiatry. 2005 Jul 15;58(2):158-64 [16038686] Pharmacol Ther. 2005 Oct;108(1):94-108 [16083966] AAPS J. 2005;7(3):E592-9 [16353938] Am Heart J. 2006 Mar;151(3):754.e1-754.e5 [16504646] J Pharm Pharmacol. 2006 Mar;58(3):337-44 [16536900] Drug Alcohol Depend. 2006 Oct 1;84(3):256-63 [16631323] Curr Psychiatry Rep. 2006 Oct;8(5):345-54 [16968614] Drug Alcohol Depend. 2007 Jan 5;86(1):22-9 [16769180] Ann N Y Acad Sci. 2006 Nov;1083:239-51 [17148743] Am J Addict. 2007 Mar-Apr;16(2):71-8 [17453607] Addiction. 2007 Apr;102 Suppl 1:107-13 [17493059] Psychopharmacology (Berl). 2000 Feb;148(3):251-62 [10755738] J Pharmacol Exp Ther. 2001 Mar;296(3):1023-34 [11181937] Arch Gen Psychiatry. 2001 Apr;58(4):322-8 [11296091] J Pharmacol Exp Ther. 2001 Jul;298(1):172-9 [11408539] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] Psychopharmacology (Berl). 2007 Aug;193(2):235-45 [17406858] Expert Opin Investig Drugs. 2007 Aug;16(8):1285-94 [17685876] Psychopharmacology (Berl). 2007 Oct;194(3):381-93 [17605004] Am J Addict. 2007 Sep-Oct;16(5):331-42 [17882603] Psychopharmacology (Berl). 2007 Nov;194(4):505-15 [17619859] Pharmacol Ther. 2007 Nov;116(2):306-21 [17868902] Drug Alcohol Depend. 2008 Jan 1;92(1-3):282-5 [17719727] Neuropsychopharmacology. 2008 Mar;33(4):761-8 [17568397] Pharmacol Biochem Behav. 2008 Apr;89(2):200-8 [18207225] Biochem Pharmacol. 2008 Mar 15;75(6):1411-5 [18191815] Expert Rev Neurother. 2008 Mar;8(3):479-91 [18345976] Clin Pharmacol Ther. 2008 Apr;83(4):627-30 [18212797] Am J Addict. 2008 Mar-Apr;17(2):161-4 [18393061] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. AN - 69566116; 18802068 AB - Nonalcoholic steatohepatitis (NASH), the most common cause of chronic liver fibrosis, progresses to cirrhosis in up to 20% of patients. We report that hepatic stellate cells (HSC) in sinusoidal lesions of liver of patients with NASH express high levels of high-affinity IL-13R (IL-13Ralpha2), which is colocalized with smooth muscle actin, whereas fatty liver and normal liver specimens do not express IL-13Ralpha2. HSCs engineered to overexpress IL-13Ralpha2 respond to IL-13 and induce TGFB1 promoter activity and TGF-beta1 production. We also developed NASH in rats by feeding a choline-deficient l-amino acid diet. These rats developed liver fibrosis as assessed by H&E staining, Masson's trichrome and Sirius red staining, and hydroxyproline assays. Treatment of these rats with IL-13R-directed cytotoxin caused a substantial decline in fibrosis and liver enzymes without organ toxicity. These studies demonstrate that functional IL-13Ralpha2 are overexpressed in activated HSCs involved in NASH and that IL-13 cytotoxin ameliorates pathological features of NASH in rat liver, indicating a novel role of this cytotoxin in potential therapy. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Shimamura, Takeshi AU - Fujisawa, Toshio AU - Husain, Syed R AU - Kioi, Mitomu AU - Nakajima, Atsushi AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 4656 EP - 4665 VL - 181 IS - 7 KW - Cytotoxins KW - 0 KW - Exotoxins KW - IL13-PE38 KW - Interleukin-13 KW - Interleukin-13 Receptor alpha2 Subunit KW - RNA, Messenger KW - Receptors, Interleukin-13 KW - Recombinant Fusion Proteins KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Hepatic Stellate Cells -- pathology KW - Gene Expression Regulation -- immunology KW - Humans KW - Disease Models, Animal KW - Cell Line, Tumor KW - Interleukin-13 Receptor alpha2 Subunit -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Rats KW - Hepatic Stellate Cells -- metabolism KW - Rats, Inbred F344 KW - Interleukin-13 Receptor alpha2 Subunit -- physiology KW - Cells, Cultured KW - Interleukin-13 Receptor alpha2 Subunit -- genetics KW - Signal Transduction -- immunology KW - Hepatic Stellate Cells -- immunology KW - Male KW - Cell Line KW - Cytotoxins -- metabolism KW - Fatty Liver -- metabolism KW - Liver Cirrhosis -- therapy KW - Recombinant Fusion Proteins -- physiology KW - Fatty Liver -- immunology KW - Exotoxins -- physiology KW - Interleukin-13 -- physiology KW - Fatty Liver -- therapy KW - Interleukin-13 -- therapeutic use KW - Cytotoxins -- therapeutic use KW - Receptors, Interleukin-13 -- physiology KW - Liver Cirrhosis -- metabolism KW - Liver Cirrhosis -- immunology KW - Exotoxins -- therapeutic use KW - Recombinant Fusion Proteins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69566116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Novel+role+of+IL-13+in+fibrosis+induced+by+nonalcoholic+steatohepatitis+and+its+amelioration+by+IL-13R-directed+cytotoxin+in+a+rat+model.&rft.au=Shimamura%2C+Takeshi%3BFujisawa%2C+Toshio%3BHusain%2C+Syed+R%3BKioi%2C+Mitomu%3BNakajima%2C+Atsushi%3BPuri%2C+Raj+K&rft.aulast=Shimamura&rft.aufirst=Takeshi&rft.date=2008-10-01&rft.volume=181&rft.issue=7&rft.spage=4656&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment. AN - 69556004; 18798697 AB - The impact of an inflammatory response, as well as interactions between the immune and nervous systems, are rapidly assuming major roles in neurodegenerative disease and injury. However, it is now appreciated that the exact nature of such responses can differ with each type of insult and interaction. More recently, neuroinflammation and the associated cellular response of microglia are being considered for their contribution to neurotoxicity of environmental agents; yet, so far, the inclusion of inflammatory end points into neurotoxicity assessment have relied primarily on relatively limited measures or driven by in vitro models of neurotoxicity. To present background information on relevant biological considerations of neuroinflammation and the microglia response demonstrating the complex integrative nature of these biological processes and raising concern with regards to translation of effects demonstrated in vitro to the in vivo situation. Specific points are addressed that would influence the design and interpretation of neuroinflammation with regards to neurotoxicology assessment. There is a complex and dynamic response in the brain to regulate inflammatory processes and maintain a normal homeostatic level. The classification of such responses as beneficial or detrimental is an oversimplification. Neuroinflammation should be considered as a balanced network of processes in which subtle modifications can shift the cells toward disparate outcomes. The tendency to overinterpret data obtained in an isolated culture system should be discouraged. Rather, the use of cross-disciplinary approaches to evaluate several end points should be incorporated into the assessment of inflammatory contributions to the neurotoxicity of environmental exposures. JF - Expert opinion on drug metabolism & toxicology AU - Harry, Gaylia Jean AU - Kraft, Andrew D AD - National Institute of Environmental Health Sciences, National Institutes of Health, Neurotoxicology Group, Laboratory of Neurobiology, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1265 EP - 1277 VL - 4 IS - 10 SN - 1742-5255, 1742-5255 KW - Inflammation Mediators KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Neurodegenerative Diseases -- metabolism KW - Cell Culture Techniques KW - Nervous System -- metabolism KW - Down-Regulation -- immunology KW - Nervous System -- pathology KW - Models, Biological KW - Inflammation Mediators -- metabolism KW - Neurotoxicity Syndromes -- diagnosis KW - Inflammation -- physiopathology KW - Neurotoxicity Syndromes -- etiology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69556004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Neuroinflammation+and+microglia%3A+considerations+and+approaches+for+neurotoxicity+assessment.&rft.au=Harry%2C+Gaylia+Jean%3BKraft%2C+Andrew+D&rft.aulast=Harry&rft.aufirst=Gaylia&rft.date=2008-10-01&rft.volume=4&rft.issue=10&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.4.10.1265 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci Res. 1998 Aug 1;53(3):361-7 [9698164] J Neurosci. 1998 Aug 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Immunol. 2007 Jan;28(1):12-8 [17129764] Brain Res. 2007 Feb 2;1131(1):17-28 [17161388] Nat Rev Immunol. 2007 Feb;7(2):161-7 [17220915] J Neuroimmunol. 2007 Feb;183(1-2):125-32 [17229471] J Neurosci. 2007 Mar 7;27(10):2596-605 [17344397] Brain Behav Immun. 2007 May;21(4):367-73 [17234380] Neuroreport. 2007 Mar 26;18(5):425-9 [17496797] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.4.10.1265 ER - TY - JOUR T1 - Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. AN - 69546384; 18368483 AB - Using primary rat mesencephalic neuron-glia cultures as an in vitro model of Parkinson's disease (PD), we tested the effect of curcumin, a natural dietary pigment with well-known anti-inflammation effects, on dopaminergic (DA) degeneration. Curcumin pretreatment mitigated LPS-induced DA neurotoxicity in a concentration-dependent manner and curcumin post-treatment also showed protective effect. Microglia depletion abolished this protective effect of curcumin, indicating that microglia play an important role in this effect. Supportively, observation by immunocytochemistry staining using OX-42 antibody showed that curcumin treatment inhibited LPS-induced morphological change of microglia. Besides, LPS-induced production of many proinflammatory factors and their gene expressions decreased dramatically after curcumin treatment. Results also revealed that curcumin treatment decreased LPS-induced activation of two transcription factors--nuclear factors kappaB (NF-kappaB) and activator protein-1 (AP-1). Taken together, our study implicated that curcumin might be a potential preventive and therapeutic strategy for inflammation-related neurodegenerative diseases. JF - Neurochemical research AU - Yang, Sufen AU - Zhang, Dan AU - Yang, Zhengqin AU - Hu, Xiaoming AU - Qian, Steven AU - Liu, Jie AU - Wilson, Belinda AU - Block, Michelle AU - Hong, Jau-Shyong AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental, Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 2044 EP - 2053 VL - 33 IS - 10 KW - Anti-Inflammatory Agents KW - 0 KW - Interleukin-1beta KW - Lipopolysaccharides KW - NF-kappa B KW - Transcription Factor AP-1 KW - Tumor Necrosis Factor-alpha KW - Curcumin KW - IT942ZTH98 KW - Dinoprostone KW - K7Q1JQR04M KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Dinoprostone -- biosynthesis KW - Transcription Factor AP-1 -- metabolism KW - Interleukin-1beta -- antagonists & inhibitors KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Neuroglia -- physiology KW - Rats KW - Microglia -- physiology KW - Rats, Inbred F344 KW - Interleukin-1beta -- biosynthesis KW - Cells, Cultured KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Dinoprostone -- antagonists & inhibitors KW - NF-kappa B -- metabolism KW - Neurons -- drug effects KW - Neurons -- physiology KW - Dopamine -- physiology KW - Lipopolysaccharides -- toxicity KW - Curcumin -- pharmacology KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69546384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Curcumin+protects+dopaminergic+neuron+against+LPS+induced+neurotoxicity+in+primary+rat+neuron%2Fglia+culture.&rft.au=Yang%2C+Sufen%3BZhang%2C+Dan%3BYang%2C+Zhengqin%3BHu%2C+Xiaoming%3BQian%2C+Steven%3BLiu%2C+Jie%3BWilson%2C+Belinda%3BBlock%2C+Michelle%3BHong%2C+Jau-Shyong&rft.aulast=Yang&rft.aufirst=Sufen&rft.date=2008-10-01&rft.volume=33&rft.issue=10&rft.spage=2044&rft.isbn=&rft.btitle=&rft.title=Neurochemical+research&rft.issn=1573-6903&rft_id=info:doi/10.1007%2Fs11064-008-9675-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-08 N1 - Date created - 2008-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11064-008-9675-z ER - TY - JOUR T1 - From UVs to metastases: modeling melanoma initiation and progression in the mouse. AN - 69543649; 18787547 AB - Cutaneous malignant melanoma is highly invasive and capable of metastasizing to distant sites where it is typically resistant to available therapy. While striving to prevent or eradicate melanoma, researchers have two significant advantages not shared by those working on many other cancers. The main environmental etiological agent, UV radiation, is known and melanocytic lesions are excisable for molecular analysis from most stages. Yet knowledge about how UV initiates melanoma has been insufficient to achieve prevention, and the understanding of metastatic mechanisms has been inadequate to reduce mortality. Here, we review the value of melanoma mouse models, focusing on these critical early and late stages. JF - The Journal of investigative dermatology AU - Zaidi, M Raza AU - Day, Chi-Ping AU - Merlino, Glenn AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4264, USA. Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 2381 EP - 2391 VL - 128 IS - 10 KW - Index Medicus KW - Animals KW - Disease Progression KW - Melanoma -- pathology KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms, Radiation-Induced -- pathology KW - Skin Neoplasms -- etiology KW - Melanoma -- secondary KW - Melanoma -- etiology KW - Ultraviolet Rays -- adverse effects KW - Skin Neoplasms -- pathology KW - Disease Models, Animal KW - Mice KW - Skin Neoplasms -- secondary KW - Neoplasms, Radiation-Induced -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69543649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=From+UVs+to+metastases%3A+modeling+melanoma+initiation+and+progression+in+the+mouse.&rft.au=Zaidi%2C+M+Raza%3BDay%2C+Chi-Ping%3BMerlino%2C+Glenn&rft.aulast=Zaidi&rft.aufirst=M&rft.date=2008-10-01&rft.volume=128&rft.issue=10&rft.spage=2381&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=1523-1747&rft_id=info:doi/10.1038%2Fjid.2008.177 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-22 N1 - Date created - 2008-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/jid.2008.177 ER - TY - JOUR T1 - Tobacco use and secondhand smoke exposure during pregnancy: an investigative survey of women in 9 developing nations. AN - 69538838; 18309125 AB - We examined pregnant women's use of cigarettes and other tobacco products and the exposure of pregnant women and their young children to secondhand smoke (SHS) in 9 nations in Latin America, Asia, and Africa. Face-to-face surveys were administered to 7961 pregnant women (more than 700 per site) between October 2004 and September 2005. At all Latin American sites, pregnant women commonly reported that they had ever tried cigarette smoking (range: 78.3% [Uruguay] to 35.0% [Guatemala]). The highest levels of current smoking were found in Uruguay (18.3%), Argentina (10.3%), and Brazil (6.1%). Experimentation with smokeless tobacco occurred in the Democratic Republic of the Congo and India; one third of all respondents in Orissa, India, were current smokeless tobacco users. SHS exposure was common: between 91.6% (Pakistan) and 17.1% (Democratic Republic of the Congo) of pregnant women reported that smoking was permitted in their home. Pregnant women's tobacco use and SHS exposure are current or emerging problems in several low- and middle-income nations, jeopardizing ongoing efforts to improve maternal and child health. JF - American journal of public health AU - Bloch, Michele AU - Althabe, Fernando AU - Onyamboko, Marie AU - Kaseba-Sata, Christine AU - Castilla, Eduardo E AU - Freire, Salvio AU - Garces, Ana L AU - Parida, Sailajanandan AU - Goudar, Shivaprasad S AU - Kadir, Muhammad Masood AU - Goco, Norman AU - Thornberry, Jutta AU - Daniels, Magdalena AU - Bartz, Janet AU - Hartwell, Tyler AU - Moss, Nancy AU - Goldenberg, Robert AD - Tobacco Control Research Branch, National Cancer Institute, Executive Plaza North, Room 4038, 6130 Executive Blvd, MSC 7337, Bethesda, MD 20892-7337, USA. blochm@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1833 EP - 1840 VL - 98 IS - 10 KW - Tobacco Smoke Pollution KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - India -- epidemiology KW - Guatemala -- epidemiology KW - Humans KW - Brazil -- epidemiology KW - Pakistan -- epidemiology KW - Uruguay -- epidemiology KW - Ecuador -- epidemiology KW - Pregnancy KW - Population Surveillance KW - Cross-Sectional Studies KW - Risk Factors KW - Adult KW - Health Surveys KW - Surveys and Questionnaires KW - Argentina -- epidemiology KW - Health Knowledge, Attitudes, Practice KW - Middle Aged KW - Adolescent KW - Democratic Republic of the Congo -- epidemiology KW - Zambia -- epidemiology KW - Female KW - Pregnant Women -- psychology KW - Developing Countries -- statistics & numerical data KW - Attitude to Health KW - Pregnancy Complications -- psychology KW - Tobacco Smoke Pollution -- statistics & numerical data KW - Pregnancy Complications -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69538838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Tobacco+use+and+secondhand+smoke+exposure+during+pregnancy%3A+an+investigative+survey+of+women+in+9+developing+nations.&rft.au=Bloch%2C+Michele%3BAlthabe%2C+Fernando%3BOnyamboko%2C+Marie%3BKaseba-Sata%2C+Christine%3BCastilla%2C+Eduardo+E%3BFreire%2C+Salvio%3BGarces%2C+Ana+L%3BParida%2C+Sailajanandan%3BGoudar%2C+Shivaprasad+S%3BKadir%2C+Muhammad+Masood%3BGoco%2C+Norman%3BThornberry%2C+Jutta%3BDaniels%2C+Magdalena%3BBartz%2C+Janet%3BHartwell%2C+Tyler%3BMoss%2C+Nancy%3BGoldenberg%2C+Robert&rft.aulast=Bloch&rft.aufirst=Michele&rft.date=2008-10-01&rft.volume=98&rft.issue=10&rft.spage=1833&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/10.2105%2FAJPH.2007.117887 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-26 N1 - Date created - 2008-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Tob Control. 2000 Mar;9(1):3-8 [10691743] PLoS Med. 2007 Jan;4(1):e20 [17227135] Clin Infect Dis. 2000 Sep;31(3):808-12 [11017836] Am J Public Health. 2001 Feb;91(2):191-3 [11211624] Tob Control. 2001 Sep;10(3):212-7 [11544383] Tob Control. 2002 Sep;11(3):252-70 [12198280] Lancet. 2002 Nov 2;360(9343):1347-60 [12423980] Bull World Health Organ. 2003;81(1):48-52 [12640476] J Sch Health. 2003 Aug;73(6):207-15 [12899101] Am J Obstet Gynecol. 2003 Oct;189(4):939-43 [14586330] Am J Public Health. 2004 Feb;94(2):331-7 [14759951] BMJ. 2004 Apr 3;328(7443):801-6 [15070637] Nicotine Tob Res. 2004 Apr;6 Suppl 2:S217-38 [15203823] BMJ. 2004 Jun 26;328(7455):1538 [15198947] Thorax. 2004 Jul;59(7):623-30 [15223875] N Y State J Med. 1985 Jul;85(7):335-40 [3900827] J Am Med Womens Assoc. 1996 Jan-Apr;51(1-2):48-51 [8868549] J Am Med Womens Assoc. 1996 Jan-Apr;51(1-2):63-6 [8868552] Health Psychol. 1996 Sep;15(5):355-61 [8891714] Lancet Oncol. 2004 Dec;5(12):708 [15600001] Lancet. 2005 Mar 19-25;365(9464):1087-98 [15781104] Am J Public Health. 2005 Jun;95(6):1009-15 [15914826] Epidemiology. 2006 Jan;17(1):47-51 [16357594] Science. 2006 Jan 13;311(5758):162-7 [16410496] Lancet. 2006 Mar 4;367(9512):749-53 [16517275] Am J Public Health. 2006 Jun;96(6):1060-5 [16670229] Sex Transm Infect. 2007 Feb;83(1):41-6 [16923740] Lancet. 2007 May 19;369(9574):1758-61 [17512860] Arch Pediatr Adolesc Med. 2007 Jul;161(7):704-10 [17606835] Bull World Health Organ. 2000;78(7):891-901 [10994262] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2105/AJPH.2007.117887 ER - TY - JOUR T1 - Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress. AN - 69532922; 18625256 AB - Ethanol exerts effects on the brain noradrenergic system, and these are thought to contribute to the sedative/hypnotic (depressant) effects of ethanol. Recent studies suggest that the norepinephrine transporter (NET) plays an important role in modulating ethanol's depressant effects. The aim of the present study was to further characterize this role. Transporter blockers with varying affinity for NET versus the serotonin transporter (desipramine>fluoxetine>citalopram) were tested for their ability to alter ethanol's depressant effects, and for comparison, hypothermic effects. Effects of desipramine on another depressant, pentobarbital, were examined. Desipramine potentiation of ethanol's depressant effects was assessed following depletion of brain norepinephrine via N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4) treatment, or depletion of brain 5-HT via para-chlorophenylalanine methyl ester hydrochloride (PCPA) treatment. The effects of co-administration of either the selective alpha2-adrenoreceptor agonist (dexmedetomidine) or the selective alpha2-adrenoreceptor antagonist (atipamezole) on desipramine's effect on ethanol's depressant effects were examined. Given the close link between stress, ethanol and norepinephrine, desipramine potentiation of ethanol's depressant effects was tested following repeated forced swim stress. Results showed that desipramine, but not SERT-selective doses of citalopram or fluoxetine, strongly potentiated the depressant (not hypothermic) effects of ethanol. These effects were mimicked by dexmedetomidine and blocked by atipamezole, but not by depletion of either norepinephrine or 5-HT. Desipramine potentiation of ethanol's depressant effects was abolished following repeated stress. Present findings further support a major role for NET and the alpha2-adrenoreceptor in modulating the depressant effects of ethanol, with possible implications for understanding the role of noradrenergic dysfunction in stress-related alcoholism. JF - Neuropharmacology AU - Boyce-Rustay, Janel M AU - Palachick, Benjamin AU - Hefner, Kathryn AU - Chen, Yi-Chyan AU - Karlsson, Rose-Marie AU - Millstein, Rachel A AU - Harvey-White, Judith AU - Holmes, Andrew AD - Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, USA. janel.boyce-rustay@abbott.com Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 803 EP - 811 VL - 55 IS - 5 SN - 0028-3908, 0028-3908 KW - Adrenergic Agents KW - 0 KW - Antidepressive Agents KW - Receptors, Adrenergic, alpha-2 KW - 4-chlorophenylalanine methyl ester KW - 23434-96-0 KW - Serotonin KW - 333DO1RDJY KW - Ethanol KW - 3K9958V90M KW - Fenclonine KW - R5J7E3L9SP KW - Desipramine KW - TG537D343B KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Behavior, Animal KW - Fenclonine -- pharmacology KW - Adrenergic Agents -- pharmacology KW - Sleep -- drug effects KW - Norepinephrine -- metabolism KW - Fenclonine -- analogs & derivatives KW - Mice, Inbred C57BL KW - Serotonin -- metabolism KW - Drug Synergism KW - Male KW - Antidepressive Agents -- pharmacology KW - Desipramine -- pharmacology KW - Desipramine -- adverse effects KW - Stress, Psychological -- physiopathology KW - Depression -- drug therapy KW - Antidepressive Agents -- adverse effects KW - Receptors, Adrenergic, alpha-2 -- physiology KW - Depression -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69532922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Desipramine+potentiation+of+the+acute+depressant+effects+of+ethanol%3A+modulation+by+alpha2-adrenoreceptors+and+stress.&rft.au=Boyce-Rustay%2C+Janel+M%3BPalachick%2C+Benjamin%3BHefner%2C+Kathryn%3BChen%2C+Yi-Chyan%3BKarlsson%2C+Rose-Marie%3BMillstein%2C+Rachel+A%3BHarvey-White%2C+Judith%3BHolmes%2C+Andrew&rft.aulast=Boyce-Rustay&rft.aufirst=Janel&rft.date=2008-10-01&rft.volume=55&rft.issue=5&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.06.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Pharmacol. 2002 Feb 2;436(3):197-205 [11858799] 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[11082458] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2008.06.032 ER - TY - JOUR T1 - Does increased urination frequency protect against bladder cancer? AN - 69385657; 18623081 AB - Experimental studies suggest that increased urination frequency may reduce bladder cancer risk if carcinogens are present in the urine. Only 2 small studies of the effect of increased urination frequency on bladder cancer risk in humans have been conducted with conflicting results. Our purpose was to evaluate the effect of urination frequency on risk of bladder cancer in a large, multicenter case-control study. We analyzed data based on interviews conducted with 884 patients with newly diagnosed, bladder cancer and 996 controls from 1998 to 2001 in Spain. We observed a consistent, inverse trend in risk with increasing nighttime voiding frequency in both men (p = 0.0003) and women (p = 0.07); voiding at least 2 times per night was associated with a significant, 40-50% risk reduction. The protective effect of nocturia was apparent among study participants with low, moderate and high water consumption. The risk associated with cigarette smoking was reduced by nocturia. Compared with nonsmokers who did not urinate at night, current smokers who did not urinate at night had an OR of 7.0 (95% CI = 4.7-10.2), whereas those who voided at least twice per night had an OR of 3.3 (95% CI = 1.9-5.8) (p value for trend = 0.0005). Our findings suggest a strong protective effect of nocturia on bladder cancer risk, providing evidence in humans that bladder cancer risk is related to the contact time of the urothelium with carcinogens in urine. Increased urination frequency, coupled with possible dilution of the urine from increased water intake, may diminish the effect of urinary carcinogens on bladder cancer risk. JF - International journal of cancer AU - Silverman, Debra T AU - Alguacil, Juan AU - Rothman, Nathaniel AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Cantor, Kenneth P AU - Malats, Nuria AU - Tardon, Adonina AU - Serra, Consol AU - Garcia-Closas, Reina AU - Carrato, Alfredo AU - Lloreta, Josep AU - Samanic, Claudine AU - Dosemeci, Mustafa AU - Kogevinas, Manolis AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA. silvermd@mail.nih.gov Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 1644 EP - 1648 VL - 123 IS - 7 KW - Carcinogens KW - 0 KW - Index Medicus KW - Smoking -- urine KW - Aged, 80 and over KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Carcinogens -- analysis KW - Male KW - Female KW - Urinary Bladder Neoplasms -- prevention & control KW - Urination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69385657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Does+increased+urination+frequency+protect+against+bladder+cancer%3F&rft.au=Silverman%2C+Debra+T%3BAlguacil%2C+Juan%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BGarcia-Closas%2C+Reina%3BCarrato%2C+Alfredo%3BLloreta%2C+Josep%3BSamanic%2C+Claudine%3BDosemeci%2C+Mustafa%3BKogevinas%2C+Manolis&rft.aulast=Silverman&rft.aufirst=Debra&rft.date=2008-10-01&rft.volume=123&rft.issue=7&rft.spage=1644&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.23572 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.23572 ER - TY - JOUR T1 - Parenting Stress, Perceived Parenting Behaviors, and Adolescent Self-Concept in European American Families AN - 61715056; 200905660 AB - This study assesses whether the stresses associated with parenting a child are indirectly related to adolescent self-concept through parenting behaviors. We examined longitudinal associations among mothers and fathers parenting stress at age 10, children's perceptions of parenting at age 10, and adolescents self-concept at age 14 in 120 European American families. Mothers and fathers parenting stress was related to children's perceptions of acceptance and psychologically controlling behavior, and psychologically controlling behavior (and lax control for fathers) was related to adolescent self-concept. We further examined which domains of parenting stress and perceived parenting behaviors were associated with adolescents scholastic competence, social acceptance, physical appearance, and behavioral conduct. Parenting stress was related to specific parenting behaviors, which were, in turn, related to specific domains of self-concept in adolescence. Parenting stress appears to exert its effects on early adolescent self-concept indirectly through perceived parenting behavior. [Copyright 2008 The American Psychological Association.] JF - Journal of Family Psychology AU - Putnick, Diane L AU - Bornstein, Marc H AU - Hendricks, Charlene AU - Painter, Kathleen M AU - Suwalsky, Joan T D AU - Collins, W Andrew AD - Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Suite 8030, 6705 Rockledge Drive, Bethesda MD 20892-7971 putnickd@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 752 EP - 762 PB - American Psychological Association, Washington DC VL - 22 IS - 5 SN - 0893-3200, 0893-3200 KW - parenting stress, parenting behavior, self-concept, adolescence KW - Behavior KW - Self Concept KW - Stress KW - Parents KW - Adolescents KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61715056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Psychology&rft.atitle=Parenting+Stress%2C+Perceived+Parenting+Behaviors%2C+and+Adolescent+Self-Concept+in+European+American+Families&rft.au=Putnick%2C+Diane+L%3BBornstein%2C+Marc+H%3BHendricks%2C+Charlene%3BPainter%2C+Kathleen+M%3BSuwalsky%2C+Joan+T+D%3BCollins%2C+W+Andrew&rft.aulast=Putnick&rft.aufirst=Diane&rft.date=2008-10-01&rft.volume=22&rft.issue=5&rft.spage=752&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Psychology&rft.issn=08933200&rft_id=info:doi/10.1037%2Fa0013177 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-28 N1 - CODEN - JFPSEV N1 - SubjectsTermNotLitGenreText - Parents; Stress; Behavior; Self Concept; Adolescents DO - http://dx.doi.org/10.1037/a0013177 ER - TY - JOUR T1 - Differential Associations of Social Support and Social Connectedness With Structural Features of Social Networks and the Health Status of Older Adults AN - 61439210; 200900825 AB - Objective: This study explores the extent to which the constructs of social support and social connectedness differ in terms of their associations with the structural characteristics of social networks and the health status of older adults. Method: Trained interviewers conducted 126 face-to-face interviews with community-dwelling older adults aged 65 to 85 years. Results: Having frequent contact with network members was positively associated with social support. Network density and having network members living in close proximity were positively associated with perceived social connectedness. Furthermore, perceived social connectedness had a significant positive association with health status, whereas social support did not. Discussion: Perceived social connectedness may be relatively more important to the health and wellbeing of older adults than the perceived availability of social support. Efforts to enhance older adults' social relationships can be focused on developing friends and companions, allowing them to feel socially engaged in society. [Reprinted by permission of Sage Publications Ltd., copyright 2008.] JF - Journal of Aging and Health AU - Ashida, Sato AU - Heaney, Catherine A AD - Social and Behavioral Research Branch, National Human Genome Research Institute, 31 Center Dr.-31/B1B37C, Bethesda, MD 20892 ashidas@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 872 EP - 893 PB - Sage Publications, Thousand Oaks CA VL - 20 IS - 7 SN - 0898-2643, 0898-2643 KW - social support, social connectedness, social engagement, companionship, network characteristics KW - Elderly KW - Social Networks KW - Social Contact KW - Social Support KW - Social Integration KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61439210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aging+and+Health&rft.atitle=Differential+Associations+of+Social+Support+and+Social+Connectedness+With+Structural+Features+of+Social+Networks+and+the+Health+Status+of+Older+Adults&rft.au=Ashida%2C+Sato%3BHeaney%2C+Catherine+A&rft.aulast=Ashida&rft.aufirst=Sato&rft.date=2008-10-01&rft.volume=20&rft.issue=7&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aging+and+Health&rft.issn=08982643&rft_id=info:doi/10.1177%2F0898264308324626 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 43 N1 - Last updated - 2016-09-28 N1 - CODEN - JAHEEG N1 - SubjectsTermNotLitGenreText - Social Support; Social Integration; Social Contact; Social Networks; Elderly DO - http://dx.doi.org/10.1177/0898264308324626 ER - TY - JOUR T1 - Jihad Threat in Central Asia TT - La menace djihadiste en Grande Asie centrale AN - 59858255; 200903470 AB - The Islamic threat in Central Asia is difficult to define. Most of the currently existing movements are unarmed political groups, but some of them arouse concern. Increasing Jihad threat in the future could be liked to the Afghan & Pakistani situations. It may also be aggravated by internal crackdown on the part of rather antidemocratic states. Developments in the whole area depend on how the situation evolves in Afghanistan & Pakistan. Adapted from the source document. JF - Politique etrangere AU - Chaudet, Didier AD - Centre Russie/NEI, Ifri Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 561 EP - 573 PB - Armand Colin, France IS - 3 SN - 0032-342X, 0032-342X KW - Political Violence KW - Religious Fundamentalism KW - Islam KW - Central Asia KW - article KW - 9105: politics; national-level politics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59858255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Politique+etrangere&rft.atitle=Jihad+Threat+in+Central+Asia&rft.au=Chaudet%2C+Didier&rft.aulast=Chaudet&rft.aufirst=Didier&rft.date=2008-10-01&rft.volume=&rft.issue=3&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Politique+etrangere&rft.issn=0032342X&rft_id=info:doi/ LA - French DB - Worldwide Political Science Abstracts N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Islam; Religious Fundamentalism; Political Violence; Central Asia ER - TY - JOUR T1 - Informationist Education AN - 57680445; 200900145 AB - The National Institutes of Health (NIH) funds biomedical research and conducts its own research. One way the NIH Library supports this work is by providing librarians with biomedical training and encouraging them to become embedded with researchers and administrators. Some of these "informationists" have degrees in scientific or health fields, and all engage in ongoing training, mostly through coursework at local institutions and at NIH itself. This article elaborates on the training of NIH informationists. Past research has indicated that patrons welcome librarians with biomedical training, which may in turn lead to greater communication between librarians and researchers. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Medical Reference Services Quarterly AU - Robison, Rex R AD - National Institutes of Health Library, Building 10, Room 1L-13A, 10 Center Drive, MSC 1150, Bethesda, MD 10892-1150 robisonr@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 339 EP - 347 PB - Haworth Press, Binghamton NY VL - 27 IS - 3 SN - 0276-3869, 0276-3869 KW - Informationist, National Institutes of Health (NIH), training KW - Training KW - National Institutes of Health KW - Information professionals KW - article KW - 2.12: LIS - EDUCATION AND TRAINING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57680445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Reference+Services+Quarterly&rft.atitle=Informationist+Education&rft.au=Robison%2C+Rex+R&rft.aulast=Robison&rft.aufirst=Rex&rft.date=2008-10-01&rft.volume=27&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Medical+Reference+Services+Quarterly&rft.issn=02763869&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Training; Information professionals; National Institutes of Health ER - TY - JOUR T1 - Gamma-vinyl GABA inhibits cocaine-triggered re-instatement of drug-seeking behavior in rats by a non-dopaminergic mechanism AN - 57267248; 200902329 AB - Relapse to drug use is a core feature of addiction. Previous studies demonstrate that ^D*g-vinyl GABA (GVG), an irreversible GABA transaminase inhibitor, attenuates the acute rewarding effects of cocaine and other addictive drugs. We here report that systemic administration of GVG (25-300 mg/kg) dose-dependently inhibits cocaine- or sucrose-induced reinstatement of reward-seeking behavior in rats. In vivo microdialysis data indicated that the same doses of GVG dose-dependently elevate extracellular GABA levels in the nucleus accumbens (NAc). However, GVG, when administered systemically or locally into the NAc, failed to inhibit either basal or cocaine-priming enhanced NAc dopamine in either naive rats or cocaine extinction rats. These data suggest that: (1) GVG significantly inhibits cocaine- or sucrose-triggered reinstatement of reward-seeking behavior; and (2) a GABAergic-, but not dopaminergic-, dependent mechanism may underlie the antagonism by GVG of cocaine-triggered reinstatement of drug-seeking behavior, at least with respect to GVG's action on the NAc. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Peng, Xiao-Qing AU - Li, Xia AU - Gilbert, Jeremy G AU - Pak, Arlene C AU - Ashby, Charles R, Jr AU - Brodie, Jonathan D AU - Dewey, Stephen L AU - Gardner, Eliot L AU - Xi, Zheng-Xiong AD - Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, United States Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 216 EP - 225 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 97 IS - 3 SN - 0376-8716, 0376-8716 KW - Cocaine KW - Dopamine KW - GABA KW - Gamma-vinyl GABA KW - Reinstatement KW - Relapse KW - Addictive behaviour KW - Drug dependency KW - Models KW - Gamma-aminobutyric acid KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57267248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Gamma-vinyl+GABA+inhibits+cocaine-triggered+re-instatement+of+drug-seeking+behavior+in+rats+by+a+non-dopaminergic+mechanism&rft.au=Peng%2C+Xiao-Qing%3BLi%2C+Xia%3BGilbert%2C+Jeremy+G%3BPak%2C+Arlene+C%3BAshby%2C+Charles+R%2C+Jr%3BBrodie%2C+Jonathan+D%3BDewey%2C+Stephen+L%3BGardner%2C+Eliot+L%3BXi%2C+Zheng-Xiong&rft.aulast=Peng&rft.aufirst=Xiao-Qing&rft.date=2008-10-01&rft.volume=97&rft.issue=3&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.10.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Cocaine; Relapse; Gamma-aminobutyric acid; Drug dependency; Models; Addictive behaviour DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.10.004 ER - TY - JOUR T1 - Two simple approaches for validating a binary surrogate endpoint using data from multiple trials AN - 57252783; 200823177 AB - A surrogate endpoint is an endpoint that is observed before a true endpoint and is used to draw conclusions about the effect of intervention on true endpoint. To gauge confidence in the use of a surrogate endpoint, it must be validated. Two simple validation methods using data from multiple trials with surrogate and true endpoints are discussed: an estimation method extending previous work and new method based on hypothesis tests. The validation methods were applied to two data sets, each involving 10 randomized trials: one for patients with early colon cancer where the true endpoint was survival status at eight years and surrogate endpoint was cancer recurrence status at three years, and one for patients with advanced colorectal cancer where the true endpoint was survival status at 12 months and the surrogate endpoint was cancer recurrence status at six months. The estimation method uses the surrogate endpoint in the new trial and a model relating surrogate and true endpoints in previous trials to predict the effect of intervention on true endpoint in the new trial. For validation, each trial was successively treated as the 'new' trial and a comparison was made between predicted and observed effects of intervention on true endpoint. Performance of the surrogate endpoint was good in both data sets. The hypothesis testing method involves the z-statistic for the surrogate endpoint, which is the estimated effect of intervention on surrogate endpoint divided by its standard error. To use this z-statistic to test a null hypothesis of no effect of intervention on true endpoint, the critical value is increased above a standard level of 1.96 to a level determined by the relationships between surrogate and true endpoints in the data sets. This elevated critical value could be used for accelerated approval. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Baker, Stuart G AD - Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA sb16i@nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 505 EP - 514 PB - Hodder Arnold, London UK VL - 17 IS - 5 SN - 0962-2802, 0962-2802 KW - Statistics KW - Colorectal cancer KW - Surrogates KW - Validation KW - Recurrence KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57252783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Two+simple+approaches+for+validating+a+binary+surrogate+endpoint+using+data+from+multiple+trials&rft.au=Baker%2C+Stuart+G&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2008-10-01&rft.volume=17&rft.issue=5&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280207081861 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-12-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Surrogates; Validation; Cancer; Recurrence; Statistics; Colorectal cancer DO - http://dx.doi.org/10.1177/0962280207081861 ER - TY - JOUR T1 - Remission Status and Cortical Thickness in Childhood-Onset Schizophrenia AN - 57249801; 200900332 AB - Objective: Few studies have examined prediction of schizophrenia outcome in relation to brain magnetic resonance imaging measures. In this study, remission status at the time of discharge was examined in relation to admission cortical thickness for childhood-onset schizophrenia probands. We hypothesized that total, frontal, temporal, and parietal gray matter thickness would be greater in patients who subsequently remit. Method: The relation between admission cortical brain thickness on magnetic resonance imaging and remission status at the time of discharge an average of 3 months later was examined for 56 individuals (32 males) ages 6 to 19 diagnosed with childhood-onset schizophrenia. Cortical thickness was measured across the cerebral hemispheres at admission. Discharge remission criteria were adapted from the 2005 Remission in Schizophrenia Working Group criteria. Results: Patients remitted at discharge (n = 16 [29%]) had thicker regional cortex in left orbitofrontal, left superior, and middle temporal gyri and bilateral postcentral and angular gyri (p less than or equal to .008). Conclusions: Our results provide neuroanatomic correlates of clinical remission in schizophrenia and evidence that response to treatment may be mediated by these cortical brain regions. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Greenstein, Deanna K AU - Wolfe, Sarah AU - Gochman, Peter AU - Rapoport, Judith L AU - Gogtay, Nitin AD - Child Psychiatry Branch, NIMH/NIH, Bldg. 10, Room 3N 202, Bethesda, MD 20892-1600 Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1133 EP - 1140 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 10 SN - 0890-8567, 0890-8567 KW - childhood-onset schizophrenia, magnetic resonance imaging, remission, cortical thickness KW - Schizophrenia KW - Magnetic resonance imaging KW - Brain KW - Remission KW - Neuroanatomy KW - Childhood onset KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57249801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Remission+Status+and+Cortical+Thickness+in+Childhood-Onset+Schizophrenia&rft.au=Greenstein%2C+Deanna+K%3BWolfe%2C+Sarah%3BGochman%2C+Peter%3BRapoport%2C+Judith+L%3BGogtay%2C+Nitin&rft.aulast=Greenstein&rft.aufirst=Deanna&rft.date=2008-10-01&rft.volume=47&rft.issue=10&rft.spage=1133&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e3181825b0c LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Remission; Schizophrenia; Neuroanatomy; Brain; Magnetic resonance imaging; Childhood onset DO - http://dx.doi.org/10.1097/CHI.0b013e3181825b0c ER - TY - JOUR T1 - Childhood-Onset Schizophrenia: Insights From Neuroimaging Studies AN - 57248776; 200900322 AB - Advances in neuroimaging allow prospective study of human brain development. Studies on pediatric populations are particularly informative because they explore the pathophysiological processes that are tied to important periods of brain development. Furthermore, childhood-onset counterparts of typical adult-onset illnesses usually show a more severe phenotype, one that is less likely to be influenced by environmental factors and more likely to show genetic influences. 1 Such samples thus provide an opportunity to study the illness in its relatively pure form and that may also increase the likelihood of identifying causal genetic events. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Gogtay, Nitin AU - Rapoport, Judith L AD - Child Psychiatry Branch, NIMH, NIH, Building 10, Room 3N202, 10 Center Drive, MSC-1600, Bethesda, MD 20892 gogtayn@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - October 2008 SP - 1120 EP - 1124 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 10 SN - 0890-8567, 0890-8567 KW - Schizophrenia KW - Paediatrics KW - Genetics KW - Pathophysiological aspects KW - Neuroimaging KW - Brain KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57248776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Childhood-Onset+Schizophrenia%3A+Insights+From+Neuroimaging+Studies&rft.au=Gogtay%2C+Nitin%3BRapoport%2C+Judith+L&rft.aulast=Gogtay&rft.aufirst=Nitin&rft.date=2008-10-01&rft.volume=47&rft.issue=10&rft.spage=1120&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31817eed7a LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Brain; Schizophrenia; Pathophysiological aspects; Genetics; Paediatrics DO - http://dx.doi.org/10.1097/CHI.0b013e31817eed7a ER - TY - JOUR T1 - Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats AN - 57238464; 200902330 AB - Gabapentin is a ^Dg-aminobutyric acid (GABA) analogue, with GABAmimetic pharmacological properties. Gabapentin is used for the treatment of seizures, anxiety and neuropathic pain. It has been proposed that gabapentin may be useful in the treatment of cocaine dependence. However, clinical trials with gabapentin have shown conflicting results, while preclinical studies are sparse. In the present study, we investigated the effects of gabapentin on intravenous cocaine self-administration and cocaine-triggered reinstatement of drug-seeking behavior, as well as on cocaine-enhanced dopamine (DA) in the nucleus accumbens (NAc). We found that gabapentin (25-200 mg/kg, i.p., 30 min or 2 h prior to cocaine) failed to inhibit intravenous cocaine (0.5 mg/kg/infusion) self-administration under a fixed-ratio reinforcement schedule or cocaine-triggered reinstatement of cocaine-seeking behavior. In vivo microdialysis showed that the same doses of gabapentin produced a modest increase (50%, p < 0.05) in extracellular NAc GABA levels, but failed to alter either basal or cocaine-enhanced NAc DA. These data suggest that gabapentin is a weak GABA-mimic drug. At the doses tested, it has no effect in the addiction-related animal behavioral models here tested. This is in striking contrast to positive findings in the same animal models shown by another GABAmimetic -- ^Dg-vinyl GABA (see companion piece to present article). [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Peng, Xiao-Qing AU - Li, Xia AU - Li, Jie AU - Ramachandran, P Veeraraghavan AU - Gagare, Pravin D AU - Pratihar, Debarshi AU - Ashby, Charles R, Jr AU - Gardner, Eliot L AU - Xi, Zheng-Xiong AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, United States Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 207 EP - 215 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 97 IS - 3 SN - 0376-8716, 0376-8716 KW - Gabapentin KW - Cocaine KW - Dopamine KW - GABA KW - Self-administration KW - Relapse KW - Intravenous drug addicts KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57238464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Effects+of+gabapentin+on+cocaine+self-administration%2C+cocaine-triggered+relapse+and+cocaine-enhanced+nucleus+accumbens+dopamine+in+rats&rft.au=Peng%2C+Xiao-Qing%3BLi%2C+Xia%3BLi%2C+Jie%3BRamachandran%2C+P+Veeraraghavan%3BGagare%2C+Pravin+D%3BPratihar%2C+Debarshi%3BAshby%2C+Charles+R%2C+Jr%3BGardner%2C+Eliot+L%3BXi%2C+Zheng-Xiong&rft.aulast=Peng&rft.aufirst=Xiao-Qing&rft.date=2008-10-01&rft.volume=97&rft.issue=3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.09.019 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Cocaine; Gabapentin; Intravenous drug addicts; Dopamine; Relapse DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.09.019 ER - TY - JOUR T1 - Personality trait similarity between spouses in four cultures AN - 37149756; 3873781 AB - We examined patterns of trait similarity (assortative mating) in married couples in four cultures, using both self-reports and spouse ratings on versions of the Revised NEO Personality Inventory. There was evidence of a subtle but pervasive perceived contrast bias in the spouse-rating data. However, there was strong agreement across methods of assessment and moderate agreement across cultures in the pattern of results. Most assortment effects were small, but correlations exceeding .40 were seen for a subset of traits, chiefly from the Openness and Agreeableness domains. Except in Russia, where more positive assortment was seen for younger couples, comparisons of younger and older cohorts showed little systematic difference. This suggested that mate selection, rather than convergence over time, accounted for similarity. Future research on personality similarity in dyads can utilize different designs but should assess personality at both domain and the facet levels. Reprinted by permission of Blackwell Publishers JF - Journal of personality AU - McCrae, Robert R AU - Martin, Thomas A AU - Hrebícková, Martina AU - Urbánek, Tomás AU - Boomsma, Dorret I AU - Willemsen, Gonneke AU - Costa, Jr., Paul T. AD - National Institute on Aging, NIH, DHHS ; Susquehanna University ; Czech Academy of Sciences ; Free University of Amsterdam Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1137 EP - 1163 VL - 76 IS - 5 SN - 0022-3506, 0022-3506 KW - Sociology KW - Comparative analysis KW - Husbands KW - Wives KW - Psychology KW - Personality traits KW - Personality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37149756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=Personality+trait+similarity+between+spouses+in+four+cultures&rft.au=McCrae%2C+Robert+R%3BMartin%2C+Thomas+A%3BHreb%C3%ADckov%C3%A1%2C+Martina%3BUrb%C3%A1nek%2C+Tom%C3%A1s%3BBoomsma%2C+Dorret+I%3BWillemsen%2C+Gonneke%3BCosta%2C+Jr.%2C+Paul+T.&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2008-10-01&rft.volume=76&rft.issue=5&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fj.1467-6494.2008.00517.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6145 4777 6093; 13577 13598 5421 6091; 2630 971; 9429 9416 2153; 9416 2153; 10404 DO - http://dx.doi.org/10.1111/j.1467-6494.2008.00517.x ER - TY - JOUR T1 - Different strokes for different gangs? An analysis of capital among Latino and Asian gang members AN - 36986305; 3780921 AB - Gang activity and membership were noted to be significantly related to financial rewards. As such, gang membership and gang activity should also be understood from an economic perspective. In this article, Pierre Bourdieu's framework of capital is used to analyze two separate samples of Latino and Asian gang members. Stark contrasts in socioeconomic backgrounds are recorded among the two samples of gang members, and gang membership and activities are also noticeably dissimilar. Accessibility to economic, cultural, and social capital is argued to affect gang membership and activities. The results suggest that the availability of legitimate and illegitimate capital greatly affects the trajectory and the length of gang involvement. Also, gangs provide significant material and social capital for the respondents of the study. JF - Sociological perspectives AU - Pih, Kay Kei-Ho AU - De La Rosa, Mario AU - Rugh, Douglas AU - Mao, KuoRay AD - California State University ; Florida International University ; National Institute on Drug Abuse ; University of Kansas Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 473 EP - 494 VL - 51 IS - 3 SN - 0731-1214, 0731-1214 KW - Political Science KW - Comparative analysis KW - International crime KW - Gangs KW - Group membership KW - Socioeconomic status KW - Latin America KW - Networks KW - Social capital KW - Corruption KW - Organized crime KW - Asia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36986305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sociological+perspectives&rft.atitle=Different+strokes+for+different+gangs%3F+An+analysis+of+capital+among+Latino+and+Asian+gang+members&rft.au=Pih%2C+Kay+Kei-Ho%3BDe+La+Rosa%2C+Mario%3BRugh%2C+Douglas%3BMao%2C+KuoRay&rft.aulast=Pih&rft.aufirst=Kay&rft.date=2008-10-01&rft.volume=51&rft.issue=3&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Sociological+perspectives&rft.issn=07311214&rft_id=info:doi/10.1525%2Fsop.2008.51.3.473 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5407; 2630 971; 6709 3015 11881; 9031 3015 11881; 11988 4011 3974 9390 11932 2328 11935 5837 2360 2688 2449 10404 11936; 5658 5636 5676 971; 2909; 8634; 11780 1952; 210 14; 30 DO - http://dx.doi.org/10.1525/sop.2008.51.3.473 ER - TY - JOUR T1 - Effects of program exposure and engagement with tailored prevention communication on sun protection by young adolescents AN - 36976741; 3775069 AB - Few family-based interventions to increase sun safe behavior among adolescents have been evaluated. The present study tested an intervention that included tailored and nontailored print communications delivered by mail to adolescents (age 11 to 15) and their parents who were also participating in an evaluation of an in-school intervention. The use of sunscreen, protective clothing, and avoidance of the sun were promoted, and family communication and environmental change strategies were fostered. Adolescents and their parents were pretested in May of 2002 and posttested from August to October. Adolescents (N = 599) were stratified on experimental condition in the in-school study (in-school intervention vs control) and randomly were assigned from within strata to receive (N = 288) or not receive (N = 311) the summer intervention materials. No statistically significant effects were found for adolescents between the randomized experimental conditions. Parents' had increased knowledge (F = 5.52, p < .05) and propensity to have their child wear sunglasses (F = 4.07, p < .05). Greater program exposure/engagement led to enhanced sun protection behavior (e.g., fewer sunburns) and psychosocial factors among adolescents and parents. Greater exposure/engagement led to improvements in family interaction and home environment (e.g., shade audit completed). Future research is needed on exposure/engagement with family-based health messaging and on family-based sun safety programs for adolescents. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Reynolds, Kim AU - Buller, David AU - Yaroch, Amy AU - Maloy, Julie AU - Geno, Cristy AU - Cutter, Gary AD - Claremont Graduate University ; Klein Buendel, Inc. ; National Cancer Institute, USA ; Kaiser Permanente of Colorado ; University of Alabama, Birmingham Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 619 EP - 636 VL - 13 IS - 7 SN - 1081-0730, 1081-0730 KW - Anthropology KW - Risk KW - Statistics KW - Skin KW - Sun KW - Communication KW - Empirical research KW - Youth KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36976741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Effects+of+program+exposure+and+engagement+with+tailored+prevention+communication+on+sun+protection+by+young+adolescents&rft.au=Reynolds%2C+Kim%3BBuller%2C+David%3BYaroch%2C+Amy%3BMaloy%2C+Julie%3BGeno%2C+Cristy%3BCutter%2C+Gary&rft.aulast=Reynolds&rft.aufirst=Kim&rft.date=2008-10-01&rft.volume=13&rft.issue=7&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730802412149 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 593; 13779 652 5676 646 6091; 12386 12166 9055 12092; 11714 1678; 2572; 4200 10902; 12233; 11035 DO - http://dx.doi.org/10.1080/10810730802412149 ER - TY - JOUR T1 - A PHASE II MULTICENTRIC PROSPECTIVE TRIAL ON HEPATIC ARTERIAL YTTHRIUM MICROSPHERES AS SALVAGE THERAPY IN UNRESECTABLE, CHEMOREFRACTORY COLORECTAL LIVER METASTASES AN - 21245610; 10275563 AB - Background: Intra-arterial injection of super(90)Y resin microspheres radiotherapy (SIRT) enables delivery of tumorcidal doses of radiation to malignant tumor, with minimal damage to adjacent tissue. This multicentre phase II study is the first prospective evaluation of SIRT as salvage therapy for patients with colorectal liver metastases who had failed prior oxaliplatin- and irinotecan-based regimens. Methods: Eligible patients had a life expectancy of >6 months, adequate hepatic and renal function and an absence of major vascular anomalies and pulmonary shunt >10%. The gastroduodenal and right gastric arteries were embolized before injection of microspheres (median dose 1.7 GBq; range 0.9-2.2) into the hepatic artery by arteriography. Results: Patients were enrolled and followed up for a median of 11 months (mos) (range 2-27). Of 50 eligible patients, 38 (76%) had received at least 4 lines of chemotherapy. Most patients had synchronous disease (72%), >4 hepatic metastases (58%) (median size 50 mm; range 8-120), involving 25-50% of the liver tissue (60%) and bilateral spread (70%). Early and late (after 48 h) WHO G1-2 toxic events (mostly fever and pain) were observed in 16% and 22% of patients, respectively. One responding patient died after 60 days due to liver failure. Of 46 patients who were evaluable for response using RECIST criteria, 1 patient (2%) had a complete response (CR), 11 (22%) a partial response (PR), 12 (24%) stable disease (SD) and 22 (44%) progressive disease (PD). In responders (CR + PR + SD), the maximum diameter of nodules diminished to 35 mm. The Kaplan-Meyer overall median survival was 13 (CI 7-18) mos, with a significant difference (p=0.0006) between responders 16 (CI 13-19) mos and PD 8 (CI 4-12) mos. At 2 years, survival was 40.3% and 0% in responders and PD, respectively. The median time to progression (mostly extrahepatic) was 4 (CI 3-5) mos. Conclusion: In heavily pretreated patients, super(90)Y resin microspheres produced an encouraging median survival, with acceptable toxicity, that compares favorably with previous phase II/III studies of chemotherapy regimens used as third- or subsequent lines of therapy. JF - Anticancer Research AU - Cosimelli, M AU - Cagol, P AU - Carpanese, L AU - Fiore, F AU - Gasparini, D AU - Geatti, O AU - Golfieri, R AU - Izzo, F AU - Sciuto, R AU - Maini, CL AD - Regina Elena National Cancer Institute, Rome, Italy Y1 - 2008/10// PY - 2008 DA - Oct 2008 VL - 28 IS - 5C SN - 0250-7005, 0250-7005 KW - Toxicology Abstracts KW - Resins KW - Liver diseases KW - Chemotherapy KW - Life span KW - Survival KW - Radiotherapy KW - Pain KW - Tumors KW - Toxicity KW - Clinical trials KW - Nodules KW - Metastases KW - Fever KW - hepatic artery KW - Arteriography KW - Renal function KW - Radiation KW - Lung KW - Shunts KW - Liver KW - microspheres KW - Vascular system KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21245610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+Research&rft.atitle=A+PHASE+II+MULTICENTRIC+PROSPECTIVE+TRIAL+ON+HEPATIC+ARTERIAL+YTTHRIUM+MICROSPHERES+AS+SALVAGE+THERAPY+IN+UNRESECTABLE%2C+CHEMOREFRACTORY+COLORECTAL+LIVER+METASTASES&rft.au=Cosimelli%2C+M%3BCagol%2C+P%3BCarpanese%2C+L%3BFiore%2C+F%3BGasparini%2C+D%3BGeatti%2C+O%3BGolfieri%2C+R%3BIzzo%2C+F%3BSciuto%2C+R%3BMaini%2C+CL&rft.aulast=Cosimelli&rft.aufirst=M&rft.date=2008-10-01&rft.volume=28&rft.issue=5C&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Anticancer+Research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Resins; Liver diseases; Chemotherapy; Life span; Radiotherapy; Survival; Pain; Toxicity; Tumors; Clinical trials; Nodules; hepatic artery; Fever; Metastases; Radiation; Renal function; Arteriography; Lung; Shunts; microspheres; Liver; Vascular system ER - TY - JOUR T1 - Feast or famine: autophagy control and engineering in eukaryotic cell culture AN - 21192744; 8853309 AB - Autophagy is a degradative process playing a role in both cell death and cell survival. Its presence is well conserved both in lower and higher eukaryotes. Recent studies have shown that activation or inhibition of autophagy may be possible in biotechnologically important species including mammalian cells and filamentous fungi using both environmental manipulation and genetic engineering. As our understanding of the autophagic biochemical pathways increases and monitoring methods become more user-friendly, the potential exists to obtain an optimum level of autophagy. This may allow for maximum cell survival and production of proteins and other metabolites in these industrially important eukaryotes. JF - Current Opinion in Biotechnology AU - Zustiak, Matthew P AU - Pollack, Judith K AU - Marten, Mark R AU - Betenbaugh, Michael J AD - Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States, zustiakm@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 518 EP - 526 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 5 SN - 0958-1669, 0958-1669 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Famine KW - Cell death KW - Mammalian cells KW - Genetic engineering KW - Reviews KW - Fungi KW - Metabolites KW - Cell culture KW - Phagocytosis KW - W 30910:Imaging KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21192744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Feast+or+famine%3A+autophagy+control+and+engineering+in+eukaryotic+cell+culture&rft.au=Zustiak%2C+Matthew+P%3BPollack%2C+Judith+K%3BMarten%2C+Mark+R%3BBetenbaugh%2C+Michael+J&rft.aulast=Zustiak&rft.aufirst=Matthew&rft.date=2008-10-01&rft.volume=19&rft.issue=5&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2008.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell survival; Famine; Cell death; Mammalian cells; Fungi; Reviews; Genetic engineering; Cell culture; Metabolites; Phagocytosis DO - http://dx.doi.org/10.1016/j.copbio.2008.07.007 ER - TY - JOUR T1 - Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array AN - 21062662; 8571804 AB - To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. We also constructed and determined the efficacy of a panel of 186 ancestry informative markers. An average of 1465 loci were genotyped at an average completion rate of 91.3%, with an average call rate of 98.3% and replication rate of 99.7%. Completion and call rates were lowered by the performance of two datasets, highlighting the importance of the DNA quality in high throughput assays. A comparison of haplotypes captured by the Addictions Array tagging SNPs and commercially available whole-genome arrays from Illumina and Affymetrix shows comparable performance of the tag SNPs to the best whole-genome array in all populations for which data are available. Arrays of haplotype-tagged candidate genes, such as this addictions-focused array, represent a cost-effective approach to generate high-quality SNP genotyping data useful for the haplotype-based analysis of panels of genes such as these 130 genes of interest to alcohol and addictions researchers. The inclusion of the 186 ancestry informative markers allows for the detection and correction for admixture and further enhances the utility of the array. JF - Alcohol and Alcoholism AU - Hodgkinson, CA AU - Yuan, Q AU - Xu, K AU - Shen, P-H AU - Heinz, E AU - Lobos, E A AU - Binder, E B AU - Cubells, J AU - Ehlers, CL AU - Gelemter, J AU - Mann, J AU - Riley, B AU - Roy, A AU - Tabakoff, B AD - Laboratory of Neurogenetics, NIAAA, 5625 Fishers Lane, Room 3S32 MSC9412, Rockville, MD 20852-1728, USA, chodg@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 505 EP - 515 VL - 43 IS - 5 SN - 0735-0414, 0735-0414 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Anxiety KW - Replication KW - Genotyping KW - Drug abuse KW - Mood KW - Vocalization behavior KW - Haplotypes KW - Single-nucleotide polymorphism KW - Information processing KW - Alcoholism KW - Addiction KW - Drug addiction KW - Ethanol KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30900:Methods KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21062662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+Alcoholism&rft.atitle=Addictions+Biology%3A+Haplotype-Based+Analysis+for+130+Candidate+Genes+on+a+Single+Array&rft.au=Hodgkinson%2C+CA%3BYuan%2C+Q%3BXu%2C+K%3BShen%2C+P-H%3BHeinz%2C+E%3BLobos%2C+E+A%3BBinder%2C+E+B%3BCubells%2C+J%3BEhlers%2C+CL%3BGelemter%2C+J%3BMann%2C+J%3BRiley%2C+B%3BRoy%2C+A%3BTabakoff%2C+B&rft.aulast=Hodgkinson&rft.aufirst=CA&rft.date=2008-10-01&rft.volume=43&rft.issue=5&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+Alcoholism&rft.issn=07350414&rft_id=info:doi/10.1093%2Falcalc%2Fagn032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Anxiety; Replication; Genotyping; Drug abuse; Mood; Haplotypes; Vocalization behavior; Single-nucleotide polymorphism; Information processing; Alcoholism; Addiction; Drug addiction; Ethanol DO - http://dx.doi.org/10.1093/alcalc/agn032 ER - TY - JOUR T1 - Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness AN - 21052987; 8585550 AB - Background. Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics. Methods. We examined relevant information from the most recent influenza pandemic that occurred during the era prior to the use of antibiotics, the 1918-1919 'Spanish flu' pandemic. We examined lung tissue sections obtained during 58 autopsies and reviewed pathologic and bacteriologic data from 109 published autopsy series that described 8398 individual autopsy investigations. Results. The postmortem samples we examined from people who died of influenza during 1918-1919 uniformly exhibited severe changes indicative of bacterial pneumonia. Bacteriologic and histopathologic results from published autopsy series clearly and consistently implicated secondary bacterial pneumonia caused by common upper respiratory-tract bacteria in most influenza fatalities. Conclusions. The majority of deaths in the 1918-1919 influenza pandemic likely resulted directly from secondary bacterial pneumonia caused by common upper respiratory-tract bacteria. Less substantial data from the subsequent 1957 and 1968 pandemics are consistent with these findings. If severe pandemic influenza is largely a problem of viral- bacterial copathogenesis, pandemic planning needs to go beyond addressing the viral cause alone (e.g., influenza vaccines and antiviral drugs). Prevention, diagnosis, prophylaxis, and treatment of secondary bacterial pneumonia, as well as stockpiling of antibiotics and bacterial vaccines, should also be high priorities for pandemic planning. JF - Journal of Infectious Diseases AU - Morens, David M AU - Taubenberger, Jeffery K AU - Fauci, Anthony S AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, dmorens@niaid.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 962 EP - 970 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 198 IS - 7 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Bacteria KW - Autopsy KW - Data processing KW - Antibiotics KW - Influenza KW - pandemics KW - Antiviral agents KW - Lung KW - Reviews KW - Prophylaxis KW - Vaccines KW - Pneumonia KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21052987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Predominant+Role+of+Bacterial+Pneumonia+as+a+Cause+of+Death+in+Pandemic+Influenza%3A+Implications+for+Pandemic+Influenza+Preparedness&rft.au=Morens%2C+David+M%3BTaubenberger%2C+Jeffery+K%3BFauci%2C+Anthony+S&rft.aulast=Morens&rft.aufirst=David&rft.date=2008-10-01&rft.volume=198&rft.issue=7&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F591708 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Influenza; Autopsy; pandemics; Data processing; Antiviral agents; Lung; Reviews; Prophylaxis; Antibiotics; Vaccines; Pneumonia; Bacteria DO - http://dx.doi.org/10.1086/591708 ER - TY - JOUR T1 - Erratum to ''TRPC1: The link between functionally distinct store-operated calcium channels'' [Cell Calcium 42 (2007) 213-223] AN - 21028568; 8493907 JF - Cell Calcium AU - Ambudkar, I S AU - Ong, H L AU - Liu, X AU - Bandyopadhyay, B C AU - Cheng, K T AD - GTTB, NIDCR, NIH, Bethesda, MD 20892, USA Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 427 PB - Churchill Livingstone, Robert Stevenson House 1-3 Baxter's Place Edinburgh EH1 3AF United Kingdom, [URL:http://www.intl.elsevierhealth.com/] VL - 44 IS - 4 SN - 0143-4160, 0143-4160 KW - Aqualine Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21028568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Calcium&rft.atitle=Erratum+to+%27%27TRPC1%3A+The+link+between+functionally+distinct+store-operated+calcium+channels%27%27+%5BCell+Calcium+42+%282007%29+213-223%5D&rft.au=Ambudkar%2C+I+S%3BOng%2C+H+L%3BLiu%2C+X%3BBandyopadhyay%2C+B+C%3BCheng%2C+K+T&rft.aulast=Ambudkar&rft.aufirst=I&rft.date=2008-10-01&rft.volume=44&rft.issue=4&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Cell+Calcium&rft.issn=01434160&rft_id=info:doi/10.1016%2Fj.ceca.2008.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.ceca.2008.02.004 ER - TY - JOUR T1 - Synthetic oligonucleotides as modulators of inflammation AN - 20976999; 11068512 AB - Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate human B cells and plasmacytoid dendritic cells, promote the production of Th1 and proinflammatory cytokines, and trigger the maturation/activation of professional APC. CpG ODN are finding use in the treatment of cancer, allergy, and infection. In contrast, ODN containing multiple TTAGGG motifs mimic the immunosuppressive activity of self-DNA, down-regulating the production of proinflammatory and Th1 cytokines. Preclinical studies suggest that "suppressive" ODN may slow or prevent diseases characterized by pathologic immune stimulation, including autoimmunity and septic shock. Extensive studies in animal models suggest that the therapeutic value of CpG and TTAGGG ODN may be optimized by early administration. JF - Journal of Leukocyte Biology AU - Klinman, D AU - Shirota, H AU - Tross, D AU - Sato, T AU - Klaschik, S AD - NCI, Bldg. 567, Rm. 205, Frederick, MD 21702, USA, klinmand@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 958 EP - 964 VL - 84 IS - 4 SN - 0741-5400, 0741-5400 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Lymphocytes B KW - Helper cells KW - Autoimmune diseases KW - Leukocytes KW - Animal models KW - CpG islands KW - Septic shock KW - Infection KW - Immunosuppressive agents KW - Oligonucleotides KW - Cancer KW - Cell activation KW - Inflammation KW - Dendritic cells KW - Hypersensitivity KW - adenomatous polyposis coli KW - Immunostimulation KW - Lymphocytes T KW - Cytokines KW - Antigen-presenting cells KW - N 14840:Antisense, Nucleotide Analogs KW - F 06925:Hypersensitivity KW - A 01490:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20976999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Synthetic+oligonucleotides+as+modulators+of+inflammation&rft.au=Klinman%2C+D%3BShirota%2C+H%3BTross%2C+D%3BSato%2C+T%3BKlaschik%2C+S&rft.aulast=Klinman&rft.aufirst=D&rft.date=2008-10-01&rft.volume=84&rft.issue=4&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Lymphocytes B; Helper cells; Leukocytes; Autoimmune diseases; Animal models; Septic shock; CpG islands; Infection; Oligonucleotides; Immunosuppressive agents; Cancer; Inflammation; Cell activation; Dendritic cells; Hypersensitivity; adenomatous polyposis coli; Immunostimulation; Lymphocytes T; Cytokines; Antigen-presenting cells ER - TY - JOUR T1 - Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: An application of muscle pain concepts to myofascial pain syndrome AN - 20976056; 8567685 AB - This article discusses muscle pain concepts in the context of myofascial pain syndrome (MPS) and summarizes microdialysis studies that have surveyed the biochemical sis of this musculoskeletal pain condition. Though MPS is a common type of non-articular pain, its pathophysiology is only beginning to be understood due to its enormous complexity. MPS is characterized by the presence of myofascial trigger points (MTrPs), which are defined as hyperirritable nodules located within a taut nd of skeletal muscle. rPs may be active (spontaneously painful and symptomatic) or latent (non- spontaneously painful). Painful rPs activate muscle nociceptors that, upon sustained noxious stimulation, initiate motor and sensory changes in the peripheral and central nervous systems. This process is called sensitization. In order to investigate the peripheral factors that influence the sensitization process, a microdialysis technique was developed to quantitatively measure the biochemical milieu of skeletal muscle. Biochemical differences were found between active and latent rPs, as well as in comparison with healthy muscle tissue. In this paper we relate the findings of elevated levels of sensitizing substances within painful muscle to the current theoretical framework of muscle pain and rP development. JF - Journal of Bodywork and Movement Therapies AU - Shah, Jay P AU - Gilliams, Elizabeth A AD - Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, 10 Center Drive, Room 1-1469, 1604, Bethesda, 20892-1604 USA, jshah@mail.cc.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 371 EP - 384 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 12 IS - 4 SN - 1360-8592, 1360-8592 KW - Physical Education Index KW - Nervous system KW - Therapy KW - Muscles KW - Stimuli KW - Techniques KW - Health KW - Pain KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20976056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bodywork+and+Movement+Therapies&rft.atitle=Uncovering+the+biochemical+milieu+of+myofascial+trigger+points+using+in+vivo+microdialysis%3A+An+application+of+muscle+pain+concepts+to+myofascial+pain+syndrome&rft.au=Shah%2C+Jay+P%3BGilliams%2C+Elizabeth+A&rft.aulast=Shah&rft.aufirst=Jay&rft.date=2008-10-01&rft.volume=12&rft.issue=4&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bodywork+and+Movement+Therapies&rft.issn=13608592&rft_id=info:doi/10.1016%2Fj.jbmt.2008.06.006 LA - English DB - Physical Education Index N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Muscles; Pain; Techniques; Therapy; Health; Nervous system; Stimuli DO - http://dx.doi.org/10.1016/j.jbmt.2008.06.006 ER - TY - JOUR T1 - Some evidence of effects of environmental chemicals on the endocrine system in children AN - 20948098; 8325448 AB - Pollutant chemicals that are widespread in the environment can affect endocrine function in laboratory experiments and in wildlife. Although human beings are commonly exposed to such pollutant chemicals, the exposures are generally low and clear effects on endocrine function from such exposures have been difficult to demonstrate. Human data including both exposure to the chemical agent and the endocrine outcome are reviewed here, including age at weaning, age at puberty, anogenital distance, and sex ratio at birth, and the strength of the evidence are discussed. Although endocrine disruption in humans by pollutant chemicals remains largely undemonstrated, the underlying science is sound and the potential for such effects is real. JF - International Journal of Hygiene and Environmental Health AU - Rogan, Walter J AU - Ragan, N Beth AD - Epidemiology Branch, Mail Drop A3-05, P.O. Box 12233, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA, rogan@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 659 EP - 667 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 210 IS - 5 SN - 1438-4639, 1438-4639 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Endocrine disruptors KW - Environmental chemicals KW - Lactation KW - Thyroid function KW - Sex ratio KW - Puberty KW - Age KW - Data processing KW - Laboratory testing KW - endocrine disruptors KW - Anogenital KW - Wildlife KW - Pollution effects KW - Weaning KW - sex ratio KW - Children KW - Birth KW - Pollutants KW - Reviews KW - Sound KW - Chemical pollution KW - Endocrine system KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20948098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Hygiene+and+Environmental+Health&rft.atitle=Some+evidence+of+effects+of+environmental+chemicals+on+the+endocrine+system+in+children&rft.au=Rogan%2C+Walter+J%3BRagan%2C+N+Beth&rft.aulast=Rogan&rft.aufirst=Walter&rft.date=2008-10-01&rft.volume=210&rft.issue=5&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Hygiene+and+Environmental+Health&rft.issn=14384639&rft_id=info:doi/10.1016%2Fj.ijheh.2007.07.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Sex ratio; Anogenital; Endocrine disruptors; Wildlife; Weaning; Children; Birth; Pollutants; Reviews; Sound; Endocrine system; Puberty; Laboratory testing; endocrine disruptors; Pollution effects; sex ratio; Chemical pollution DO - http://dx.doi.org/10.1016/j.ijheh.2007.07.005 ER - TY - JOUR T1 - Using microarrays to study the microenvironment in tumor biology: The crucial role of statistics AN - 20886116; 8414625 AB - Microarrays represent a potentially powerful tool for better understanding the role of the microenvironment on tumor biology. To make the best use of microarray data and avoid incorrect or unsubstantiated conclusions, care must be taken in the statistical analysis. To illustrate the statistical issues involved we discuss three microarray studies related to the microenvironment and tumor biology involving: (i) prostatic stroma cells in cancer and non-cancer tissues; (ii) breast stroma and epithelial cells in breast cancer patients and non-cancer patients; and (iii) serum associated with wound response and stroma in cancer patients. Using these examples we critically discuss three types of analyses: differential gene expression, cluster analysis, and class prediction. We also discuss design issues. JF - Seminars in Cancer Biology AU - Baker, S G AU - Kramer, B S AD - National Cancer Institute, Bethesda, MD, USA, sb16i@nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 305 EP - 310 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 18 IS - 5 SN - 1044-579X, 1044-579X KW - Biotechnology and Bioengineering Abstracts KW - Stroma KW - Gene expression KW - Epithelial cells KW - Statistics KW - Data processing KW - Statistical analysis KW - Microenvironments KW - Breast cancer KW - Tumors KW - DNA microarrays KW - Wounds KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20886116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Cancer+Biology&rft.atitle=Using+microarrays+to+study+the+microenvironment+in+tumor+biology%3A+The+crucial+role+of+statistics&rft.au=Baker%2C+S+G%3BKramer%2C+B+S&rft.aulast=Baker&rft.aufirst=S&rft.date=2008-10-01&rft.volume=18&rft.issue=5&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Cancer+Biology&rft.issn=1044579X&rft_id=info:doi/10.1016%2Fj.semcancer.2008.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Stroma; Epithelial cells; Data processing; Statistics; Statistical analysis; Breast cancer; Microenvironments; Tumors; DNA microarrays; Wounds DO - http://dx.doi.org/10.1016/j.semcancer.2008.03.001 ER - TY - JOUR T1 - The changing impact of genes and environment on brain development during childhood and adolescence: Initial findings from a neuroimaging study of pediatric twins AN - 20756435; 9293756 AB - Human brain development is created through continuing complex interactions of genetic and environmental influences. The challenge of linking specific genetic or environmental risk factors to typical or atypical behaviors has led to interest in using brain structural features as an intermediate phenotype. Twin studies in adults have found that many aspects of brain anatomy are highly heritable, demonstrating that genetic factors provide a significant contribution to variation in brain structures. Less is known about the relative impact of genes and environment while the brain is actively developing. We summarize results from the ongoing National Institute of Mental Health child and adolescent twin study that suggest that heritability of different brain areas changes over the course of development in a regionally specific fashion. Areas associated with more complex reasoning abilities become increasingly heritable with maturation. The potential mechanisms by which gene-environment interactions may affect heritability values during development is discussed. JF - Development and Psychopathology AU - Lenroot, Rhoshel K AU - Giedd, Jay N AD - National Institutes of Mental Health, jg@nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1161 EP - 1175 PB - Cambridge University Press VL - 20 IS - 4 SN - 0954-5794, 0954-5794 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neuroimaging KW - Genetic factors KW - Pediatrics KW - Adolescence KW - Development KW - Children KW - Mental disorders KW - Twins KW - Reviews KW - Risk factors KW - Psychopathology KW - Heritability KW - N3 11003:Developmental neuroscience KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20756435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development+and+Psychopathology&rft.atitle=The+changing+impact+of+genes+and+environment+on+brain+development+during+childhood+and+adolescence%3A+Initial+findings+from+a+neuroimaging+study+of+pediatric+twins&rft.au=Lenroot%2C+Rhoshel+K%3BGiedd%2C+Jay+N&rft.aulast=Lenroot&rft.aufirst=Rhoshel&rft.date=2008-10-01&rft.volume=20&rft.issue=4&rft.spage=1161&rft.isbn=&rft.btitle=&rft.title=Development+and+Psychopathology&rft.issn=09545794&rft_id=info:doi/10.1017%2FS0954579408000552 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mental disorders; Genetic factors; Neuroimaging; Twins; Pediatrics; Risk factors; Reviews; Adolescence; Development; Psychopathology; Children; Heritability DO - http://dx.doi.org/10.1017/S0954579408000552 ER - TY - JOUR T1 - Replication of a genome-wide case-control study of esophageal squamous cell carcinoma AN - 20627112; 9355809 AB - In a previous pilot case-control study of individuals diagnosed with esophageal squamous cell carcinoma (ESCC) and matched controls from a high-risk area in China, we identified 38 single nucleotide polymorphisms (SNPs) associated with ESCC located in or near one of 33 genes. In our study, we attempted to replicate the results of these 38 gene-related SNPs in a new sample of 300 ESCC cases and 300 matched controls from the same study conducted in Shanxi Province, China. Among 36 evaluable SNPs, 4 were significant in one or more analyses, including SNPs located in EPHB1, PGLYRP2, PIK3C3 and SLC9A9, although the odds ratios (ORs) for these genotypes were modest. Associations were found with EPHB1/rs1515366 (OR 0.92, 95% CI 0.86-0.99; p = 0.019), PIK3C3/rs52911 (OR 0.93, 95% CI 0.88-0.99; p = 0.02) and PGLYRP2/rs959117 (OR 0.93, 95% CI, 0.86-1.01; p = 0.061) in general linear models (additive mode); and the genotype distribution differed between cases and controls for SLC9A9/rs956062 (p = 0.024). To examine these 4 genes in more detail, 40 HapMap-based tag SNPs from these 4 genes were evaluated in the same subjects and 7 additional SNPs associated with ESCC were identified. Further confirmation of these findings in other populations and other studies are needed to determine if the signals from these SNPs are indirectly associated due to linkage disequilibrium, or are directly related to biologic function and the development of ESCC. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Ng, David AU - Hu, Nan AU - Hu, Ying AU - Wang, Chaoyu AU - Giffen, Carol AU - Tang, Ze-Zhong AU - Han, Xiao-You AU - Yang, Howard H AU - Lee, Maxwell P AU - Goldstein, Alisa M AU - Taylor, Philip R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA, davidng@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1610 EP - 1615 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 7 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - Esophagus KW - Linkage disequilibrium KW - Single-nucleotide polymorphism KW - Replication KW - China, People's Rep., Shanxi Prov. KW - Risk groups KW - Population studies KW - squamous cell carcinoma KW - Genotypes KW - Additives KW - Cancer KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20627112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Replication+of+a+genome-wide+case-control+study+of+esophageal+squamous+cell+carcinoma&rft.au=Ng%2C+David%3BHu%2C+Nan%3BHu%2C+Ying%3BWang%2C+Chaoyu%3BGiffen%2C+Carol%3BTang%2C+Ze-Zhong%3BHan%2C+Xiao-You%3BYang%2C+Howard+H%3BLee%2C+Maxwell+P%3BGoldstein%2C+Alisa+M%3BTaylor%2C+Philip+R&rft.aulast=Ng&rft.aufirst=David&rft.date=2008-10-01&rft.volume=123&rft.issue=7&rft.spage=1610&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23682 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Esophagus; Linkage disequilibrium; Replication; Single-nucleotide polymorphism; Population studies; Risk groups; squamous cell carcinoma; Genotypes; Additives; Cancer; China, People's Rep., Shanxi Prov. DO - http://dx.doi.org/10.1002/ijc.23682 ER - TY - JOUR T1 - The development of antisocial behavior: What can we learn from functional neuroimaging studies? AN - 20591421; 9293762 AB - The recent development of low-risk imaging technologies, such as functional magnetic resonance imaging (fMRI), have had a significant impact on the investigation of psychopathologies in children and adolescents. This review considers what we can infer from fMRI work regarding the development of conduct disorder (CD) and oppositional defiant disorder (ODD). We make two central assumptions that are grounded in the empirical literature. First, the diagnoses of CD and ODD identify individuals with heterogeneous pathologies; that is, different developmental pathologies can receive a CDD or ODD diagnosis. This is indicated by the comorbidities associated with CD/ODD, some of which appear to be mutually exclusive at the biological level (e.g., posttraumatic stress disorder [PTSD] and psychopathic tendencies). Second, two populations of antisocial individuals can be identified: those that show an increased risk for only reactive aggression and those that show an increased risk for both reactive and instrumental aggression. We review the fMRI data indicating that particular comorbidities of CD/ODD (i.e., mood and anxiety conditions such as childhood bipolar disorder and PTSD) are associated with either increased responsiveness of neural regions implicated in the basic response to threat (e.g., the amygdala) or decreased responsiveness in regions of frontal cortex (e.g., ventromedial frontal cortex) that are implicated in the regulation of the basic threat response. We suggest why such pathology would increase the risk for reactive aggression and, in turn, lead to the association with a CD/ODD diagnosis. We also review the literature on psychopathic tendencies, a condition where the individual is at significantly elevated risk for both reactive and instrumental aggression. We show that in individuals with psychopathic tendencies, the functioning of the amygdala in stimulus-reinforcement learning and of the ventromedial frontal cortex in the representation of reinforcement expectancies is impaired. We suggest why such pathology would increase the risk for reactive and instrumental aggression and thus also lead to the association with a CD/ODD diagnosis. JF - Development and Psychopathology AU - Crowe, S L AU - Blair, RJR AD - National Institute of Mental Health, blairj@intra.nimh.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1145 EP - 1159 PB - Cambridge University Press VL - 20 IS - 4 SN - 0954-5794, 0954-5794 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neuroimaging KW - Learning KW - Data processing KW - Anxiety KW - Functional magnetic resonance imaging KW - Adolescence KW - Cortex (frontal) KW - Children KW - Post-traumatic stress disorder KW - Mood KW - Bipolar disorder KW - Risk factors KW - Reviews KW - Reinforcement KW - Social behavior KW - Risk groups KW - Amygdala KW - Psychopathology KW - Aggression KW - Expectancy KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20591421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development+and+Psychopathology&rft.atitle=The+development+of+antisocial+behavior%3A+What+can+we+learn+from+functional+neuroimaging+studies%3F&rft.au=Crowe%2C+S+L%3BBlair%2C+RJR&rft.aulast=Crowe&rft.aufirst=S&rft.date=2008-10-01&rft.volume=20&rft.issue=4&rft.spage=1145&rft.isbn=&rft.btitle=&rft.title=Development+and+Psychopathology&rft.issn=09545794&rft_id=info:doi/10.1017%2FS0954579408000540 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Learning; Neuroimaging; Data processing; Anxiety; Adolescence; Functional magnetic resonance imaging; Cortex (frontal); Children; Post-traumatic stress disorder; Mood; Bipolar disorder; Reviews; Risk factors; Social behavior; Reinforcement; Risk groups; Amygdala; Psychopathology; Aggression; Expectancy DO - http://dx.doi.org/10.1017/S0954579408000540 ER - TY - JOUR T1 - Treponema denticola TroR is a manganese- and iron-dependent transcriptional repressor AN - 20453709; 9150031 AB - SummaryTreponema denticola harbours a genetic locus with significant homology to most of the previously characterized Treponema pallidum tro operon. Within this locus are five genes (troABCDR) encoding for the components of an ATP-binding cassette cation-transport system (troABCD) and a DtxR-like transcriptional regulator (troR). In addition, a s70-like promoter and an 18bp region of dyad symmetry were identified upstream of the troA start codon. This putative operator sequence demonstrated similarity to the T.pallidum TroR (TroRTp) binding sequence; however, the position of this motif with respect to the predicted tro promoters differed. Interestingly, unlike the T.pallidum orthologue, T.denticola TroR (TroRTd) possesses a C-terminal Src homology 3-like domain commonly associated with DtxR family members. In the present study, we show that TroRTd is a manganese- and iron-dependent transcriptional repressor using Escherichia coli reporter constructs and in T.denticola. In addition, we demonstrate that although TroRTd possessing various C-terminal deletions maintain metal-sensing capacities, these truncated proteins exhibit reduced repressor activities in comparison with full-length TroRTd. Based upon these findings, we propose that TroRTd represents a novel member of the DtxR family of transcriptional regulators and is likely to play an important role in regulating both manganese and iron homeostases in this spirochaete. JF - Molecular Microbiology AU - Brett, Paul J AU - Burtnick, Mary N AU - Fenno, JChristopher AU - Gherardini, Frank C AD - 1Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA. Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 396 EP - 409 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 70 IS - 2 SN - 0950-382X, 0950-382X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Transcription KW - Treponema denticola KW - Operators KW - Promoters KW - Homology KW - Treponema pallidum KW - Globus pallidus KW - Escherichia coli KW - Codons KW - Src protein KW - Operons KW - Repressors KW - Iron KW - Manganese KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20453709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Treponema+denticola+TroR+is+a+manganese-+and+iron-dependent+transcriptional+repressor&rft.au=Brett%2C+Paul+J%3BBurtnick%2C+Mary+N%3BFenno%2C+JChristopher%3BGherardini%2C+Frank+C&rft.aulast=Brett&rft.aufirst=Paul&rft.date=2008-10-01&rft.volume=70&rft.issue=2&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06418.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Operators; Promoters; Homology; Globus pallidus; Src protein; Codons; Transcription; Operons; Manganese; Iron; Repressors; Treponema pallidum; Escherichia coli; Treponema denticola DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06418.x ER - TY - JOUR T1 - Marked Liver Tumorigenesis by Helicobacter hepaticus Requires Perinatal Exposure AN - 20257900; 8571987 AB - Background: Although severe hepatitis and liver tumors occur in a high percentage of A/J male mice naturally infected with Helicobacter hepaticus, these effects have not been observed after injection of adult mice with the bacteria. Objectives: We tested the hypothesis that perinatal exposure to the bacteria is required for liver tumorigenesis. Methods: A/J female mice were infected by intragastric (ig) or intraperitoneal (ip) treatment with 1.5 x 10 super(8) H. hepaticus before pregnancy. We examined offspring at progressive time intervals, including some kept until natural death in old age. A/J, BALB/c, and C57BL/6 weanling male mice were similarly treated ig with the bacteria and observed for up to 2 years. RESULTS: After ip bacterial infection of A/J females, 41% of their male offspring developed hepatitis and 33% had hepatocellular tumors, including 18% with hepatocellular carcinoma. Treatment by the ig route resulted in a similar incidence of hepatitis in offspring (35%) but fewer total liver tumors (8%) and carcinomas (4%). By contrast, ig instillation of H. hepaticus in weanling A/J, C57BL/6, or BALB/c mice resulted in low incidence of hepatitis (0-20%) and few liver tumors, despite presence of bacteria confirmed in feces. Conclusions: Results indicate that a high incidence of liver tumors in mice infected with H. hepaticus requires perinatal exposure. Contributing perinatal factors could include known high sensitivity of neonatal liver to tumor initiation, and/or modulation of immune response to the bacterium or its toxins. Mechanisms of human perinatal sensitivity to such phenomena can be studied with this model. JF - Environmental Health Perspectives AU - Diwan, BA AU - Sipowicz, M AU - Logsdon, D AU - Gorelick, P AU - Anver, M R AU - Kasprzak, K S AU - Anderson, L M AD - NCI at Frederick, Building 538, Room 205B, Ft. Detrick, Frederick, MD 21702 USA, andersol@mail.ncifcrf.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1352 EP - 1356 VL - 116 IS - 10 SN - 0091-6765, 0091-6765 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Environment Abstracts KW - Animal models KW - tumors KW - Infection KW - Immunomodulation KW - Models KW - Perinatal exposure KW - Helicobacter hepaticus KW - Geriatrics KW - Feces KW - offspring KW - Immunoglobulins KW - Hepatocellular carcinoma KW - Sensitivity KW - Mortality KW - Fecal coliforms KW - Tumorigenesis KW - Mice KW - Toxins KW - Carcinoma KW - Pregnancy KW - Hepatitis KW - Liver KW - Progeny KW - Immune response KW - Neonates KW - J 02410:Animal Diseases KW - V 22350:Immunology KW - X 24490:Other KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20257900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Marked+Liver+Tumorigenesis+by+Helicobacter+hepaticus+Requires+Perinatal+Exposure&rft.au=Diwan%2C+BA%3BSipowicz%2C+M%3BLogsdon%2C+D%3BGorelick%2C+P%3BAnver%2C+M+R%3BKasprzak%2C+K+S%3BAnderson%2C+L+M&rft.aulast=Diwan&rft.aufirst=BA&rft.date=2008-10-01&rft.volume=116&rft.issue=10&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11493 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tumorigenesis; Animal models; Infection; Immunomodulation; Toxins; Pregnancy; Carcinoma; Models; Hepatitis; Perinatal exposure; Geriatrics; Progeny; Neonates; Immune response; Feces; Hepatocellular carcinoma; Immunoglobulins; Mortality; Sensitivity; Fecal coliforms; Liver; Mice; tumors; offspring; Helicobacter hepaticus DO - http://dx.doi.org/10.1289/ehp.11493 ER - TY - JOUR T1 - PROSTATE CANCER STEM CELLS AN - 20148997; 10275724 AB - Recently there have been several reports of cancer stem cells (CSCs) in hematological malignancies as well as in solid tumors, such as breast, colon, glioblastoma, and prostate cancer. CSCs are the tumor-initiating cells that give rise to the multiple cell types present within a heterogeneous tumor. Moreover, CSCs are resistant to many conventional chemotherapies, resulting in recurrence of the tumor. Therefore, the targeting of these cells is central to any therapy that is to be successful in eradicating cancer. However, successful targeting of these cells requires an understanding of the biology governing the CSC's unique properties of continued self-renewal, multipotent differentiation, and tumor initiation. Using prostate CSCs as a model, we are elucidating the molecular mechanisms underlying these properties. JF - Anticancer Research AU - Hurt, E M AD - National Cancer Institute-Frederick, Center for Cancer Research, Laboratory of Cancer Prevention, Cancer Stem Cells Section, Frederick, MD 21702, USA Y1 - 2008/10// PY - 2008 DA - Oct 2008 VL - 28 IS - 5C SN - 0250-7005, 0250-7005 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Glioblastoma KW - Differentiation KW - Stem cells KW - Malignancy KW - Prostate cancer KW - Colon KW - Solid tumors KW - Chemotherapy KW - Tumors KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20148997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+Research&rft.atitle=PROSTATE+CANCER+STEM+CELLS&rft.au=Hurt%2C+E+M&rft.aulast=Hurt&rft.aufirst=E&rft.date=2008-10-01&rft.volume=28&rft.issue=5C&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Anticancer+Research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Differentiation; Glioblastoma; Molecular modelling; Malignancy; Stem cells; Prostate cancer; Colon; Solid tumors; Chemotherapy; Tumors ER - TY - JOUR T1 - The lamin B receptor under transcriptional control of C/EBPe is required for morphological but not functional maturation of neutrophils AN - 20110297; 8488029 AB - The lamin B receptor (LBR) is an integral nuclear envelope protein that interacts with chromatin and has homology to sterol reductases. Mutations in LBR result in Pelger-Hueet anomaly and HEM-Greenberg skeletal dysplasia, whereas in mice Lbr mutations result in ichthyosis. To further understand the function of the LBR and its role in disease, we derived a novel mouse model with a gene-trap insertion into the Lbr locus (Lbr super(GT/GT)). Phenotypically, the Lbr super(GT/GT) mice are similar to ichthyosis mice. The Lbr super(GT/GT) granulocytes lack a mature segmented nucleus and have a block in late maturation. Despite these changes in nuclear morphology, the innate granulocyte immune function in the killing of Staphylococcus aureus bacteria appears to be intact. Granulocyte differentiation requires the transcription factor C/EBPe. We identified C/EBPe binding sites within the Lbr promoter and used EMSAs and luciferase assays to show that Lbr is transcriptionally regulated by C/EBPe. Our findings indicate that the Lbr super(GT/GT) mice are a model for Pelger-Hueet anomaly and that Lbr, under transcriptional regulation of C/EBPe, is necessary for morphological but not necessarily functional granulocyte maturation. JF - Human Molecular Genetics AU - Cohen, Tatiana V AU - Klarmann, Kimberly D AU - Sakchaisri, Krisada AU - Cooper, Jason P AU - Kuhns, Douglas AU - Anver, Miriam AU - Johnson, Peter F AU - Williams, Simon C AU - Keller, Jonathan R AU - Stewart, Colin L AD - Cancer and Developmental Biology Laboratory, CCR. Basic Research Program, Laboratory of Cancer Prevention, SAIC-Frederick, Inc. Laboratory of Protein Dynamics and Signaling, CCR. Clinical Services Program, SAIC-Frederick, Inc. Laboratory Animal Sciences Program, Pathology/Histotechnology Laboratory, SAIC-Frederick, National Cancer Institute, Frederick, MD 21702, USA. Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 2921 EP - 2933 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 17 IS - 19 SN - 0964-6906, 0964-6906 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Chromatin KW - Animal models KW - Leukocytes (neutrophilic) KW - Lamins KW - Bone dysplasia KW - Ichthyosis KW - Promoters KW - Leukocytes (granulocytic) KW - Differentiation KW - reductase KW - Homology KW - Insertion KW - Nuclear membranes KW - Sterols KW - Gene regulation KW - Transcription factors KW - Immune response KW - Staphylococcus aureus KW - Nuclei KW - Mutation KW - Skeleton KW - J 02410:Animal Diseases KW - G 07770:Bacteria KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20110297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Molecular+Genetics&rft.atitle=The+lamin+B+receptor+under+transcriptional+control+of+C%2FEBPe+is+required+for+morphological+but+not+functional+maturation+of+neutrophils&rft.au=Cohen%2C+Tatiana+V%3BKlarmann%2C+Kimberly+D%3BSakchaisri%2C+Krisada%3BCooper%2C+Jason+P%3BKuhns%2C+Douglas%3BAnver%2C+Miriam%3BJohnson%2C+Peter+F%3BWilliams%2C+Simon+C%3BKeller%2C+Jonathan+R%3BStewart%2C+Colin+L&rft.aulast=Cohen&rft.aufirst=Tatiana&rft.date=2008-10-01&rft.volume=17&rft.issue=19&rft.spage=2921&rft.isbn=&rft.btitle=&rft.title=Human+Molecular+Genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chromatin; Leukocytes (neutrophilic); Animal models; Lamins; Bone dysplasia; Ichthyosis; Differentiation; Leukocytes (granulocytic); Promoters; reductase; Homology; Sterols; Nuclear membranes; Insertion; Transcription factors; Gene regulation; Immune response; Nuclei; Mutation; Skeleton; Staphylococcus aureus ER - TY - JOUR T1 - Alterations of the Arginine Metabolome in Asthma AN - 199561354; 18635886 AB - As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation. We hypothesized that arginine (Arg) bioavailability would be associated with airflow abnormalities and inflammation in subjects with asthma, and would be informative for asthma severity. Arg bioavailability was assessed in subjects with severe and nonsevere asthma and healthy control subjects by determination of plasma Arg relative to its metabolic products, ornithine and citrulline, and relative to methylarginine inhibitors of NO synthases, and by serum arginase activity. Inflammatory parameters, including fraction of exhaled NO (Fe(NO)), IgE, skin test positivity to allergens, bronchoalveolar lavage, and blood eosinophils, were also evaluated. Subjects with asthma had greater Arg bioavailability, but also increased Arg catabolism compared with healthy control subjects, as evidenced by higher levels of Fe(NO) and serum arginase activity. However, Arg bioavailability was positively associated with Fe(NO) only in healthy control subjects; Arg bioavailability was unrelated to Fe(NO) or other inflammatory parameters in severe or nonsevere asthma. Inflammatory parameters were related to airflow obstruction and reactivity in nonsevere asthma, but not in severe asthma. Conversely, Arg bioavailability was related to airflow obstruction in severe asthma, but not in nonsevere asthma. Modeling confirmed that measures of Arg bioavailabilty predict airflow obstruction only in severe asthma. Unlike Fe(NO), Arg bioavailability is not a surrogate measure of inflammation; however, Arg bioavailability is strongly associated with airflow abnormalities in severe asthma. JF - American Journal of Respiratory and Critical Care Medicine AU - Lara, Abigail AU - Khatri, Sumita B AU - Wang, Zeneng AU - Comhair, Suzy A A AU - Xu, Weiling AU - Dweik, Raed A AU - Bodine, Melanie AU - Levison, Bruce S AU - Hammel, Jeffrey AU - Bleecker, Eugene AU - Busse, William AU - Calhoun, William J AU - Castro, Mario AU - Chung, Kian Fan AU - Curran-Everett, Douglas AU - Gaston, Benjamin AU - Israel, Elliot AU - Jarjour, Nizar AU - Moore, Wendy AU - Peters, Stephen P AU - Teague, W Gerald AU - Wenzel, Sally AU - Hazen, Stanley L AU - Erzurum, Serpil C Y1 - 2008/10/01/ PY - 2008 DA - 2008 Oct 01 SP - 673 EP - 81 CY - New York PB - American Thoracic Society VL - 178 IS - 7 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Nitric Oxide KW - Arginine KW - Arginase KW - Spirometry KW - Humans KW - Adult KW - Case-Control Studies KW - Arginine -- blood KW - Arginase -- blood KW - Male KW - Female KW - Breath Tests KW - Asthma -- physiopathology KW - Biological Availability KW - Asthma -- metabolism KW - Arginine -- metabolism KW - Arginase -- metabolism KW - Nitric Oxide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199561354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Alterations+of+the+Arginine+Metabolome+in+Asthma&rft.au=Lara%2C+Abigail%3BKhatri%2C+Sumita+B%3BWang%2C+Zeneng%3BComhair%2C+Suzy+A+A%3BXu%2C+Weiling%3BDweik%2C+Raed+A%3BBodine%2C+Melanie%3BLevison%2C+Bruce+S%3BHammel%2C+Jeffrey%3BBleecker%2C+Eugene%3BBusse%2C+William%3BCalhoun%2C+William+J%3BCastro%2C+Mario%3BChung%2C+Kian+Fan%3BCurran-Everett%2C+Douglas%3BGaston%2C+Benjamin%3BIsrael%2C+Elliot%3BJarjour%2C+Nizar%3BMoore%2C+Wendy%3BPeters%2C+Stephen+P%3BTeague%2C+W+Gerald%3BWenzel%2C+Sally%3BHazen%2C+Stanley+L%3BErzurum%2C+Serpil+C&rft.aulast=Lara&rft.aufirst=Abigail&rft.date=2008-10-01&rft.volume=178&rft.issue=7&rft.spage=673&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Oct 1, 2008 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Cetuximab: Preclinical Evaluation of a Monoclonal Antibody Targeting EGFR for Radioimmunodiagnostic and Radioimmunotherapeutic Applications AN - 19916110; 8852834 AB - The monoclonal antibody, cetuximab, binds to epidermal growth-factor receptor and thus provides an opportunity to create both imaging and therapies that target this receptor. The potential of cetuximab as a radioimmunoconjugate, using the acyclic bifunctional chelator, CHX-A"-DTPA, was investigated. The pharmacokinetic behavior in the blood was determined in mice with and without tumors. Tumor targeting and scintigraphic imaging were evaluated in mice bearing xenografts of LS-174T (colorectal), SHAW (pancreatic), SKOV3 (ovarian), DU145 (prostate), and HT-29 (colorectal). Excellent tumor targeting was observed in each of the models with peak tumor uptakes of 59.8 plus or minus 18.1, 22.5 plus or minus 4.7, 33.3 plus or minus 5.7, 18.2 plus or minus 7.8, and 41.7 plus or minus 10.8 injected dose per gram (%ID/g) at 48-72 hours, respectively. In contrast, the highest tumor %ID/g obtained in mice bearing melanoma (A375) xenografts was 6.3 plus or minus 1.1 at 72 hours. The biodistribution of super(111)ln-cetuximab was also evaluated in nontumor-bearing mice. The highest %ID/g was observed in the liver (9.3 plus or minus 1.3 at 24 hours) and the salivary glands (8.1 plus or minus 2.8 at 72 hours). Scintigraphy showed excellent tumor targeting at 24 hours. Blood pool was evident, as expected, but cleared over time. At 168 hours, the tumor was clearly discernible with negligible background. JF - Cancer Biotherapy and Radiopharmaceuticals AU - Milenic, DE AU - Wong, K J AU - Baidoo, KE AU - Ray, G L AU - Garmestani, K AU - Williams, M AU - Brechbiel, M W AD - Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Building 10, Room 1B40, 10 Center Drive, MSC-1088, Bethesda, MD 20892, USA, dm71q@njh.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 619 EP - 632 VL - 23 IS - 5 SN - 1084-9785, 1084-9785 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Monoclonal antibodies KW - Pancreas KW - Animal models KW - Epidermal growth factor receptors KW - Tumors KW - Salivary gland KW - Chelating agents KW - Scintigraphy KW - imaging KW - Pharmacokinetics KW - Models KW - Melanoma KW - Blood KW - Liver KW - Xenografts KW - Prostate KW - W 30910:Imaging KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19916110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Biotherapy+and+Radiopharmaceuticals&rft.atitle=Cetuximab%3A+Preclinical+Evaluation+of+a+Monoclonal+Antibody+Targeting+EGFR+for+Radioimmunodiagnostic+and+Radioimmunotherapeutic+Applications&rft.au=Milenic%2C+DE%3BWong%2C+K+J%3BBaidoo%2C+KE%3BRay%2C+G+L%3BGarmestani%2C+K%3BWilliams%2C+M%3BBrechbiel%2C+M+W&rft.aulast=Milenic&rft.aufirst=DE&rft.date=2008-10-01&rft.volume=23&rft.issue=5&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Cancer+Biotherapy+and+Radiopharmaceuticals&rft.issn=10849785&rft_id=info:doi/10.1089%2Fcbr.2008.0493 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Monoclonal antibodies; Pancreas; Animal models; Epidermal growth factor receptors; Tumors; Chelating agents; Salivary gland; imaging; Scintigraphy; Pharmacokinetics; Melanoma; Models; Blood; Liver; Xenografts; Prostate DO - http://dx.doi.org/10.1089/cbr.2008.0493 ER - TY - JOUR T1 - Glycoside analogs of b-galactosylceramide, a novel class of small molecule antiviral agents that inhibit HIV-1 entry AN - 19897076; 8467599 AB - The interaction between HIV gp120 and galactose-containing cell surface glycolipids such as GalCer or Gb sub(3) is known to facilitate HIV binding to both CD4 super(+) as well as CD4 super(-) cells. In an effort to develop small molecule HIV-1 entry inhibitors with improved solubility and efficacy, we have synthesized a series of C-glycoside analogs of GalCer and tested their anti HIV-1 activity. The analogs were tested for gp120 binding using a HIV-1 (IIIB) V3-loop specific peptide. Two of the six analogs that interfered with gp120 binding also inhibited HIV Env-mediated cell-to-cell fusion and viral entry in the absence of any significant cytotoxicity. Analogs with two side chains did not show inhibition of fusion and/or infection under identical conditions. The inhibition of virus infection seen by these compounds was not coreceptor dependent, as they inhibited CXCR4, CCR5 as well as dual tropic viruses. These compounds showed inhibition of HIV entry at early steps in viral infection since the compounds were inactive if added post viral entry. Temperature-arrested state experiments showed that the compounds act at the level of virus attachment to the cells likely at a pre-CD4 engagement step. These compounds also showed inhibition of VSV glycoprotein-pseudotyped virus. The results presented here show that the glycoside derivatives of GalCer with simple side chains may serve as a novel class of small molecule HIV-1 entry inhibitors that would be active against a number of HIV isolates as well as other enveloped viruses. JF - Antiviral Research AU - Garg, H AU - Francella, N AU - Tony, KA AU - Augustine, LA AU - Barchi, J J AU - Fantini, J AU - Puri, A AU - Mootoo AU - Blumenthal, R AD - Nanobiology Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA, BlumenthalR@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 54 EP - 61 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 80 IS - 1 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Cell surface KW - Solubility KW - CXCR4 protein KW - CCR5 protein KW - Infection KW - Glycolipids KW - Glycoprotein gp120 KW - CD4 antigen KW - Cytotoxicity KW - Antiviral agents KW - glycosides KW - Human immunodeficiency virus 1 KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19897076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Glycoside+analogs+of+b-galactosylceramide%2C+a+novel+class+of+small+molecule+antiviral+agents+that+inhibit+HIV-1+entry&rft.au=Garg%2C+H%3BFrancella%2C+N%3BTony%2C+KA%3BAugustine%2C+LA%3BBarchi%2C+J+J%3BFantini%2C+J%3BPuri%2C+A%3BMootoo%3BBlumenthal%2C+R&rft.aulast=Garg&rft.aufirst=H&rft.date=2008-10-01&rft.volume=80&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2008.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Glycolipids; Cell surface; Glycoprotein gp120; Cytotoxicity; CD4 antigen; Solubility; CXCR4 protein; Antiviral agents; glycosides; CCR5 protein; Infection; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.antiviral.2008.04.004 ER - TY - JOUR T1 - 5-Aminolaevulinic acid and photodynamic therapy reduce HSV-1 replication in HaCat cells through an apoptosis-independent mechanism AN - 19878532; 8533289 AB - BackgroundPhotodynamic therapy (PDT) involves the use of a photosensitizing agent, which may require metabolic synthesis (i.e. a prodrug), followed by light activation. Numerous studies have advanced PDT as a means for treating bacteria, fungi and viruses. In this study, the photoinactivation of Herpes simplex virus type 1 (HSV-1) in human keratinocytes using 5-aminolaevulinic acid (5-ALA) was investigated. MethodsHaCat cells were infected with HSV-1 and treated with 5-ALA to verify its antiviral effect during the stages of adsorption and penetration to host cells. Immunoblot analysis was used to estimate the effect of ALA-PDT on the production of viral proteins glycoprotein D (gD), infected cell proteins (ICP) 27 and virion protein (VP) 16. We also investigated whether the effect of ALA-PDT was associated with a cellular apoptotic mechanism through DNA fragmentation and the study of p53, PARP and caspase-3 protein expression. ResultsWhile the treatment of ALA-PDT after the viral adsorption period reduced HSV-1 replication by about 70%, it did not act on the virus in the first phase of infection. The viral proteins' expressions were reduced by ALA-PDT treatments. There was no evidence of ALA-PDT-induced apoptosis. ConclusionOur data suggest that the target of photoinactivation appears to be viral replication and not a cellular response. JF - Photodermatology, Photoimmunology and Photomedicine AU - Ayala, Fabrizio AU - Grimaldi, Elena AU - Perfetto, Brunella AU - Donnarumma, Maria AU - De Filippis, Anna AU - Donnarumma, Giovanna AU - Tufano, Maria Antonietta AD - National Cancer Institute of Naples 'G. Pascale', Naples, Italy, mariaan.tufano@unina2.it Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 237 EP - 243 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 24 IS - 5 SN - 0905-4383, 0905-4383 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - 5-aminolaevulinic acid KW - HaCat cells KW - HSV-1 KW - photodynamic therapy KW - Virions KW - Apoptosis KW - Data processing KW - Replication KW - Fungi KW - Herpes simplex virus 1 KW - Infection KW - p53 protein KW - Light effects KW - glycoprotein D KW - DNA fragmentation KW - Photosensitization KW - prodrugs KW - Poly(ADP-ribose) polymerase KW - Caspase-3 KW - Adsorption KW - Keratinocytes KW - Photoinactivation KW - J 02330:Biochemistry KW - V 22320:Replication KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19878532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photodermatology%2C+Photoimmunology+and+Photomedicine&rft.atitle=5-Aminolaevulinic+acid+and+photodynamic+therapy+reduce+HSV-1+replication+in+HaCat+cells+through+an+apoptosis-independent+mechanism&rft.au=Ayala%2C+Fabrizio%3BGrimaldi%2C+Elena%3BPerfetto%2C+Brunella%3BDonnarumma%2C+Maria%3BDe+Filippis%2C+Anna%3BDonnarumma%2C+Giovanna%3BTufano%2C+Maria+Antonietta&rft.aulast=Ayala&rft.aufirst=Fabrizio&rft.date=2008-10-01&rft.volume=24&rft.issue=5&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Photodermatology%2C+Photoimmunology+and+Photomedicine&rft.issn=09054383&rft_id=info:doi/10.1111%2Fj.1600-0781.2008.00367.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virions; Data processing; Apoptosis; Replication; Fungi; photodynamic therapy; Infection; glycoprotein D; Light effects; p53 protein; DNA fragmentation; Photosensitization; prodrugs; Poly(ADP-ribose) polymerase; Adsorption; Caspase-3; Photoinactivation; Keratinocytes; Herpes simplex virus 1 DO - http://dx.doi.org/10.1111/j.1600-0781.2008.00367.x ER - TY - JOUR T1 - Arsenic-induced Aberrant Gene Expression in Fetal Mouse Primary Liver-Cell Cultures AN - 19802710; 8787991 AB - Exposure of maternal mice to inorganic arsenic through the drinking water induces liver tumors and aberrant gene expression in offspring when they reach adulthood. To help define if these are direct fetal effects of arsenic, fetal liver cells were isolated from untreated mice at gestation day 13.5 by mechanical dissection and centrifugation. Two hours after seeding the cells on collagen1-coated plates in William E media containing 10% fetal bovine serum, 1x ITS (insulin, transferrin, and selenium) and antibiotics, inorganic arsenite (0, 0.1, 0.3, and 1.0 mu M) was added to the fresh media for 72 h. Cell morphology and viability were not significantly altered by these arsenic concentrations. At the end of arsenic exposure, cells were harvested into Trizol, and total RNA was extracted, purified, and subjected to real-time reverse transcriptase polymerase chain reaction (RT-PCR) analysis. Arsenite exposure produced a concentration-dependent induction of heme oxygenase-1 (up to eight-fold) and metallothionein-1 (up to five-fold), indicative of stress response to adapt to arsenic insult. Expression of genes related to steroid metabolism, such as 17 beta -hydroxysteroid dehydrogenase-7 (HSD17 beta 7) and Cyp2a4, were increased approximately two-fold, together with increases in estrogen receptor- alpha (ER- alpha ) and ER- alpha -linked genes, such as anterior gradient-2, keratin 1-19, and trefoil factor-3. Arsenic in vitro induced a three-fold increase in the expression of alpha -fetoprotein (AFP), a biomarker associated with transplacental arsenic-induced mouse liver tumors. Thus, exposure of mouse fetal liver cells to arsenic induces adaptive responses and aberrant gene expression, which could alter genetic programming at a very early life stage, potentially contributing to tumor formation much later in life. JF - Annals of the New York Academy of Sciences AU - Liu, Jie AU - Yu, Limei AU - Tokar, Erik J AU - Bortner, Carl AU - Sifre, Maria I AU - Sun, Yang AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina, USA, Liu6@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 368 EP - 375 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1140 IS - 1 SN - 0077-8923, 0077-8923 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - arsenic KW - fetal mouse liver cells KW - adaptive response KW - aberrant gene expression KW - Hepatocytes KW - alpha -fetoprotein KW - Cell culture KW - Antibiotics KW - Insulin KW - Collagen KW - Gene expression KW - Selenium KW - Centrifugation KW - Gestation KW - RNA-directed DNA polymerase KW - Polymerase chain reaction KW - Cytology KW - Arsenic KW - Chromium KW - Arsenite KW - Developmental stages KW - Stress KW - Heme oxygenase (decyclizing) KW - Tumors KW - Steroid hormones KW - biomarkers KW - Fetuses KW - Transferrin KW - Keratin KW - RNA KW - Liver KW - Progeny KW - Drinking water KW - Estrogen receptors KW - Metabolism KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19802710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Arsenic-induced+Aberrant+Gene+Expression+in+Fetal+Mouse+Primary+Liver-Cell+Cultures&rft.au=Liu%2C+Jie%3BYu%2C+Limei%3BTokar%2C+Erik+J%3BBortner%2C+Carl%3BSifre%2C+Maria+I%3BSun%2C+Yang%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2008-10-01&rft.volume=1140&rft.issue=1&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1454.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Hepatocytes; alpha -fetoprotein; Antibiotics; Cell culture; Insulin; Collagen; Gene expression; Centrifugation; Selenium; Gestation; Cytology; Polymerase chain reaction; RNA-directed DNA polymerase; Arsenic; Chromium; Arsenite; Stress; Developmental stages; Heme oxygenase (decyclizing); Steroid hormones; Tumors; biomarkers; Fetuses; Transferrin; Keratin; RNA; Liver; Progeny; Drinking water; Estrogen receptors; Metabolism DO - http://dx.doi.org/10.1196/annals.1454.028 ER - TY - JOUR T1 - CASE REPORT: Trace Evidence of trans-Phenylpropene as a Marker of Smoked Methamphetamine AN - 19757671; 8806425 AB - This case study Investigates trans-phenylpropene as a potential marker for smoked methamphetamine. The decedent, a 31-year-old male, was found with paraphernalia that Indicated that he may have been smoking abused drugs prior to death. Methamphetamine and cocaine were detected in the residue remaining in the paraphernalia. Markers of thermal degradation of methamphetamine and cocaine were also detected in the paraphernalia. Gas chromatography-mass spectrometry (GC-MS) analysis detected trans-phenylpropene as a marker of smoked methamphetamine and anhydroecgonine methyl ester as a marker of smoked cocaine. Both trans-phenylpropene and anydroecgonine methyl ester were detected in the urine of the decedent, connecting the link between the paraphernalia for smoking and the ingestion of the pyrolysis products of methamphetamine and cocaine. Several other drugs of abuse were identified either in blood and urine or in hexane extracts of the paraphernalia, including phenylacetone, fentanyl, norfentanyl, amphetamine, ecgonine methyl ester, oxycodone, acetaminophen, chlorpheniramine, and caffeine. Using a pyrolysis GC-MS, the characteristic pyrolytic products of cocaine HCl, methamphetamine HCl, and combinations of the two were evaluated and the results showed that combining the drugs in a single run did not alter the pyrolysis pattern. The detection of trans-phenylpropene in both biological specimens and in paraphernalia is the first example of this analyte being applied as evidence of smoked methamphetamine. JF - Journal of Analytical Toxicology AU - Shakleya, D M AU - Plumley, A E AU - Kraner, J C AU - Bell, S C AU - Callery, P S AD - National Institute on Drug Abuse, Chemistry and Drug Metabolism Section, Nathan Shock Drive, Baltimore, Maryland 21224, USA Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 705 EP - 708 VL - 32 IS - 8 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Pyrolysis products KW - oxycodone KW - fentanyl KW - Drug abuse KW - Mass spectroscopy KW - Pyrolysis KW - Blood KW - Smoking KW - Methamphetamine KW - Case reports KW - Urine KW - Gas chromatography KW - Amphetamine KW - Caffeine KW - Cocaine KW - n-Hexane KW - Acetaminophen KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19757671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=CASE+REPORT%3A+Trace+Evidence+of+trans-Phenylpropene+as+a+Marker+of+Smoked+Methamphetamine&rft.au=Shakleya%2C+D+M%3BPlumley%2C+A+E%3BKraner%2C+J+C%3BBell%2C+S+C%3BCallery%2C+P+S&rft.aulast=Shakleya&rft.aufirst=D&rft.date=2008-10-01&rft.volume=32&rft.issue=8&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pyrolysis products; Drug abuse; fentanyl; oxycodone; Mass spectroscopy; Pyrolysis; Smoking; Blood; Methamphetamine; Case reports; Gas chromatography; Urine; Caffeine; Amphetamine; Cocaine; Acetaminophen; n-Hexane ER - TY - JOUR T1 - Urinary Elimination of 11-Nor-9-Carboxy- super(9)-tetrahydrocannnabinol in Cannabis Users During Continuously Monitored Abstinence AN - 19756599; 8806404 AB - The time course of 11-nor-9-carboxy- super(9)-tetrahydrocannnabinol (THCCOOH) elimination in urine was characterized in 60 cannabis users during 24 h monitored abstinence on a closed research unit for up to 30 days. Six thousand, one hundred fifty-eight individual urine specimens were screened by immunoassay with values . 50 ng/mL classified as positive. Urine specimens were confirmed for THCCOOH by gas chromatography-mass spectrometry following base hydrolysis and liquid-liquid or solid-phase extraction. In 60%, the maximum creatinine normalized concentration occurred in the first urine specimen; in 40%, peaks occurred as long as 2.9 days after admission. Data were divided into three groups, 0-50, 51-150, and > 150 ng/mg, based on the creatinine corrected initial THCCOOH concentration. There were statistically significant correlations between groups and number of days until first negative and last positive urine specimens; mean number of days were 0.6 and 4.3, 3.2 and 9.7, and 4.7 and 15.4 days, respectively, for the three groups. These data provide guidelines for interpreting urine cannabinoid test results and suggest appropriate detection windows for differentiating new cannabis use from residual drug excretion. JF - Journal of Analytical Toxicology AU - Goodwin, R S AU - Darwin, W D AU - Chiang, C N AU - Shin, M AU - Li, S-H AU - Huestis, MA AD - Chemistry and Drug Metabolism Section, Intramural Research Program and Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Rockville, Maryland, USA Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 562 EP - 569 VL - 32 IS - 8 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Data processing KW - Statistical analysis KW - Drug abuse KW - Hydrolysis KW - Mass spectroscopy KW - Creatinine KW - Cannabinoids KW - Urine KW - Gas chromatography KW - Cannabis KW - Excretion KW - Immunoassays KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19756599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Urinary+Elimination+of+11-Nor-9-Carboxy-+super%289%29-tetrahydrocannnabinol+in+Cannabis+Users+During+Continuously+Monitored+Abstinence&rft.au=Goodwin%2C+R+S%3BDarwin%2C+W+D%3BChiang%2C+C+N%3BShin%2C+M%3BLi%2C+S-H%3BHuestis%2C+MA&rft.aulast=Goodwin&rft.aufirst=R&rft.date=2008-10-01&rft.volume=32&rft.issue=8&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Creatinine; Cannabinoids; Gas chromatography; Urine; Statistical analysis; Cannabis; Excretion; Drug abuse; Immunoassays; Hydrolysis; Mass spectroscopy ER - TY - JOUR T1 - Molecular Genetics of Addiction and Related Heritable Phenotypes AN - 19720937; 8788019 AB - Genome-wide association (GWA) can elucidate molecular genetic bases for human individual differences in complex phenotypes that include vulnerability to addiction. Here, we review (a) evidence that supports polygenic models with (at least) modest heterogeneity for the genetic architectures of addiction and several related phenotypes; (b) technical and ethical aspects of importance for understanding GWA data, including genotyping in individual samples versus DNA pools, analytic approaches, power estimation, and ethical issues in genotyping individuals with illegal behaviors; (c) the samples and the data that shape our current understanding of the molecular genetics of individual differences in vulnerability to substance dependence and related phenotypes; (d) overlaps between GWA data sets for dependence on different substances; and (e) overlaps between GWA data for addictions versus other heritable, brain-based phenotypes that include bipolar disorder, cognitive ability, frontal lobe brain volume, the ability to successfully quit smoking, neuroticism, and Alzheimer's disease. These convergent results identify potential targets for drugs that might modify addictions and play roles in these other phenotypes. They add to evidence that individual differences in the quality and quantity of brain connections make pleiotropic contributions to individual differences in vulnerability to addictions and to related brain disorders and phenotypes. A 'connectivity constellation' of brain phenotypes and disorders appears to receive substantial pathogenic contributions from individual differences in a constellation of genes whose variants provide individual differences in the specification of brain connectivities during development and in adulthood. Heritable brain differences that underlie addiction vulnerability thus lie squarely in the midst of the repertoire of heritable brain differences that underlie vulnerability to other common brain disorders and phenotypes. JF - Annals of the New York Academy of Sciences AU - Uhl, George R AU - Drgon, Tomas AU - Johnson, Catherine AU - Li, Chuan-Yun AU - Contoreggi, Carlo AU - Hess, Judith AU - Naiman, Daniel AU - Liu, Qing-Rong AD - Molecular Neurobiology Branch, National Institutes of Health (NIH), Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), Baltimore, Maryland, USA, guhl@intra.nida.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 318 EP - 381 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1141 IS - 1 SN - 0077-8923, 0077-8923 KW - Genetics Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - pleiotropic KW - cell adhesion KW - Monte Carlo KW - Molecular modelling KW - Alzheimer's disease KW - Genetics KW - Smoking KW - Ethics KW - Addiction KW - Drugs KW - Substance abuse KW - Data processing KW - Neural networks KW - Genotyping KW - Neurosis KW - Brain KW - Neurodegenerative diseases KW - cognitive ability KW - Behavior KW - Cognitive ability KW - Bipolar disorder KW - Frontal lobe KW - Reviews KW - DNA KW - vulnerability KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19720937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Molecular+Genetics+of+Addiction+and+Related+Heritable+Phenotypes&rft.au=Uhl%2C+George+R%3BDrgon%2C+Tomas%3BJohnson%2C+Catherine%3BLi%2C+Chuan-Yun%3BContoreggi%2C+Carlo%3BHess%2C+Judith%3BNaiman%2C+Daniel%3BLiu%2C+Qing-Rong&rft.aulast=Uhl&rft.aufirst=George&rft.date=2008-10-01&rft.volume=1141&rft.issue=1&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1441.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Data processing; Neural networks; Genotyping; Alzheimer's disease; Brain; Neurosis; Smoking; Neurodegenerative diseases; Frontal lobe; Bipolar disorder; Cognitive ability; Ethics; Reviews; DNA; Addiction; Genetics; cognitive ability; Behavior; vulnerability; Drugs; Substance abuse DO - http://dx.doi.org/10.1196/annals.1441.018 ER - TY - JOUR T1 - Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1) AN - 19720523; 8808710 AB - Vanilloid agonists such as capsaicin activate ion flux through the TRPV1 channel, a heat- and ligand- gated cation channel that transduces painful chemical or thermal stimuli applied to peripheral nerve endings in skin or deep tissues. We have probed the SAR of a variety of 1,4-dihydropyridine (DHP) derivatives as novel 'enhancers' of TRPV1 activity by examining changes in capsaicin-induced elevations in super(45)Ca super(2+)- uptake in either cells ectopically expressing TRPV1 or in cultured dorsal root ganglion (DRG) neurons. The enhancers increased the maximal capsaicin effect on super(45)Ca super(2+)-uptake by typically 2- to 3-fold without producing an action when used alone. The DHP enhancers contained 6-aryl substitution and small alkyl groups at the 1 and 4 positions, and a 3-phenylalkylthioester was tolerated. Levels of free intracellular Ca super(2+), as measured by calcium imaging, were also increased in DRG neurons when exposed to the combination of capsaicin and the most efficacious enhancer 23 compared to capsaicin alone. Thus, DHPs can modulate TRPV1 channels in a positive fashion. JF - Bioorganic and Medicinal Chemistry AU - Roh, Eun Joo AU - Keller, Jason M AU - Olah, Zoltan AU - Iadarola, Michael J AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Building 8A, Room B1A-19 LBC, Bethesda, MD 20892-0810, USA, miadarola@dir.nidcr.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 9349 EP - 9358 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 20 SN - 0968-0896, 0968-0896 KW - Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - cation channels KW - Skin KW - Capsaicin receptors KW - Dorsal root ganglia KW - Calcium imaging KW - Capsaicin KW - Calcium (intracellular) KW - Calcium influx KW - Neurons KW - Thermal stimuli KW - Structure-activity relationships KW - Peripheral nerves KW - W 30910:Imaging KW - T 2000:Cellular Calcium KW - N3 11008:Neurochemistry KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19720523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Structure-activity+relationships+of+1%2C4-dihydropyridines+that+act+as+enhancers+of+the+vanilloid+receptor+1+%28TRPV1%29&rft.au=Roh%2C+Eun+Joo%3BKeller%2C+Jason+M%3BOlah%2C+Zoltan%3BIadarola%2C+Michael+J%3BJacobson%2C+Kenneth+A&rft.aulast=Roh&rft.aufirst=Eun&rft.date=2008-10-01&rft.volume=16&rft.issue=20&rft.spage=9349&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.08.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - cation channels; Calcium influx; Skin; Capsaicin receptors; Neurons; Dorsal root ganglia; Thermal stimuli; Calcium imaging; Structure-activity relationships; Capsaicin; Peripheral nerves; Calcium (intracellular) DO - http://dx.doi.org/10.1016/j.bmc.2008.08.048 ER - TY - JOUR T1 - Synthesis of nucleoside-based antiviral drugs in ionic liquids AN - 19718152; 8686523 AB - Nucleoside-based antiviral drugs have been synthesized using imidazolium- based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents. JF - Bioorganic and Medicinal Chemistry AU - Kumar, Vineet AU - Malhotra, Sanjay V AD - Laboratory of Synthetic Chemistry, SAIC-Frederick Inc., National Cancer Institute-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA, malhotrasa@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 5640 EP - 5642 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 20 SN - 0968-0896, 0968-0896 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Solubility KW - Antiviral agents KW - nucleosides KW - Solvents KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - N 14845:Miscellaneous KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19718152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+of+nucleoside-based+antiviral+drugs+in+ionic+liquids&rft.au=Kumar%2C+Vineet%3BMalhotra%2C+Sanjay+V&rft.aulast=Kumar&rft.aufirst=Vineet&rft.date=2008-10-01&rft.volume=18&rft.issue=20&rft.spage=5640&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2008.08.090 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Solubility; Antiviral agents; nucleosides; Solvents DO - http://dx.doi.org/10.1016/j.bmcl.2008.08.090 ER - TY - JOUR T1 - Origins and evolution of eukaryotic RNA interference AN - 19717125; 8599314 AB - Small interfering RNAs (siRNAs) and genome-encoded microRNAs (miRNAs) silence genes via complementary interactions with mRNAs. With thousands of miRNA genes identified and genome sequences of diverse eukaryotes available for comparison, the opportunity emerges for insights into the origin and evolution of RNA interference (RNAi). The miRNA repertoires of plants and animals appear to have evolved independently. However, conservation of the key proteins involved in RNAi suggests that the last common ancestor of modern eukaryotes possessed siRNA-based mechanisms. Prokaryotes have an RNAi-like defense system that is functionally analogous but not homologous to eukaryotic RNAi. The protein machinery of eukaryotic RNAi seems to have been pieced together from ancestral archaeal, bacterial and phage proteins that are involved in DNA repair and RNA processing. JF - Trends in Ecology & Evolution AU - Shabalina, SA AU - Koonin, E V AD - Building 38 A, shabalin@ncbi.nlm.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 578 EP - 587 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 23 IS - 10 SN - 0169-5347, 0169-5347 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Ecology Abstracts KW - Phages KW - Genomes KW - miRNA KW - DNA repair KW - mRNA KW - RNA processing KW - siRNA KW - Reviews KW - Conservation KW - RNA-mediated interference KW - Prokaryotes KW - Evolutionary genetics KW - Evolution KW - Gene silencing KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure KW - D 04040:Ecosystem and Ecology Studies KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19717125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Ecology+%26+Evolution&rft.atitle=Origins+and+evolution+of+eukaryotic+RNA+interference&rft.au=Shabalina%2C+SA%3BKoonin%2C+E+V&rft.aulast=Shabalina&rft.aufirst=SA&rft.date=2008-10-01&rft.volume=23&rft.issue=10&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Trends+in+Ecology+%26+Evolution&rft.issn=01695347&rft_id=info:doi/10.1016%2Fj.tree.2008.06.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Phages; miRNA; DNA repair; mRNA; RNA processing; siRNA; Reviews; RNA-mediated interference; Conservation; Evolutionary genetics; Prokaryotes; Evolution; Gene silencing DO - http://dx.doi.org/10.1016/j.tree.2008.06.005 ER - TY - JOUR T1 - An ontology-driven semantic mashup of gene and biological pathway information: Application to the domain of nicotine dependence AN - 19706849; 8566116 AB - Objectives: This paper illustrates how Semantic Web technologies (especially RDF, OWL, and SPARQL) can support information integration and make it easy to create semantic mashups (semantically integrated resources). In the context of understanding the genetic basis of nicotine dependence, we integrate gene and pathway information and show how three complex biological queries can be answered by the integrated knowledge base. Methods: We use an ontology-driven approach to integrate two gene resources (Entrez Gene and HomoloGene) and three pathway resources (KEGG, Reactome and BioCyc), for five organisms, including humans. We created the Entrez Knowledge Model (EKoM), an information model in OWL for the gene resources, and integrated it with the extant BioPAX ontology designed for pathway resources. The integrated schema is populated with data from the pathway resources, publicly available in BioPAX-compatible format, and gene resources for which a population procedure was created. The SPARQL query language is used to formulate queries over the integrated knowledge base to answer the three biological queries. Results: Simple SPARQL queries could easily identify hub genes, i.e., those genes whose gene products participate in many pathways or interact with many other gene products. The identification of the genes expressed in the brain turned out to be more difficult, due to the lack of a common identification scheme for proteins. Conclusion: Semantic Web technologies provide a valid framework for information integration in the life sciences. Ontology-driven integration represents a flexible, sustainable and extensible solution to the integration of large volumes of information. Additional resources, which enable the creation of mappings between information sources, are required to compensate for heterogeneity across namespaces. Resource page: http://knoesis.wright.edu/research/lifesci /integration/structured_data/JBI-2008/ JF - Computers and Biomedical Research AU - Sahoo, S S AU - Bodenreider, O AU - Rutter, J L AU - Skinner, K J AU - Sheth AD - National Library of Medicine, 8600 Rockville Pike, MS 3841, Building 38A, Room B1N28U, Bethesda, MD 20894, USA, olivier@nlm.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 752 EP - 765 PB - Academic Press, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 41 IS - 5 SN - 0010-4809, 0010-4809 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Integration KW - Drug dependence KW - Data processing KW - Brain KW - Language KW - Computer applications KW - Semantics KW - Models KW - Gene mapping KW - G 07880:Human Genetics KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19706849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+and+Biomedical+Research&rft.atitle=An+ontology-driven+semantic+mashup+of+gene+and+biological+pathway+information%3A+Application+to+the+domain+of+nicotine+dependence&rft.au=Sahoo%2C+S+S%3BBodenreider%2C+O%3BRutter%2C+J+L%3BSkinner%2C+K+J%3BSheth&rft.aulast=Sahoo&rft.aufirst=S&rft.date=2008-10-01&rft.volume=41&rft.issue=5&rft.spage=752&rft.isbn=&rft.btitle=&rft.title=Computers+and+Biomedical+Research&rft.issn=00104809&rft_id=info:doi/10.1016%2Fj.jbi.2008.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drug dependence; Integration; Data processing; Brain; Language; Computer applications; Gene mapping; Models; Semantics DO - http://dx.doi.org/10.1016/j.jbi.2008.02.006 ER - TY - JOUR T1 - Computational strategies for the automated design of RNA nanoscale structures from building blocks using NanoTiler AN - 19686062; 8600355 AB - One approach to designing RNA nanoscale structures is to use known RNA structural motifs such as junctions, kissing loops or bulges and to construct a molecular model by connecting these building blocks with helical struts. We previously developed an algorithm for detecting internal loops, junctions and kissing loops in RNA structures. Here we present algorithms for automating or assisting many of the steps that are involved in creating RNA structures from building blocks: (1) assembling building blocks into nanostructures using either a combinatorial search or constraint satisfaction; (2) optimizing RNA 3D ring structures to improve ring closure; (3) sequence optimisation; (4) creating a unique non-degenerate RNA topology descriptor. This effectively creates a computational pipeline for generating molecular models of RNA nanostructures and more specifically RNA ring structures with optimized sequences from RNA building blocks. We show several examples of how the algorithms can be utilized to generate RNA tecto-shapes. JF - Journal of Molecular Graphics AU - Bindewald, E AU - Grunewald, C AU - Boyle, B AU - O'Connor, M AU - Shapiro, BA AD - NCI-Frederick, Frederick, MD 21702, USA, bshapiro@ncifcrf.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 299 EP - 308 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 27 IS - 3 SN - 0263-7855, 0263-7855 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - RNA KW - Nucleotide sequence KW - Algorithms KW - Computer applications KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics&rft.atitle=Computational+strategies+for+the+automated+design+of+RNA+nanoscale+structures+from+building+blocks+using+NanoTiler&rft.au=Bindewald%2C+E%3BGrunewald%2C+C%3BBoyle%2C+B%3BO%27Connor%2C+M%3BShapiro%2C+BA&rft.aulast=Bindewald&rft.aufirst=E&rft.date=2008-10-01&rft.volume=27&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics&rft.issn=02637855&rft_id=info:doi/10.1016%2Fj.jmgm.2008.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; RNA; Nucleotide sequence; Algorithms; Computer applications DO - http://dx.doi.org/10.1016/j.jmgm.2008.05.004 ER - TY - JOUR T1 - A Robotic Platform for Quantitative High-Throughput Screening AN - 19645898; 8940105 AB - High-throughput screening (HTS) is increasingly being adopted in academic institutions, where the decoupling of screening and drug development has led to unique challenges, as well as novel uses of instrumentation, assay formulations, and software tools. Advances in technology have made automated unattended screening in the 1,536-well plate format broadly accessible and have further facilitated the exploration of new technologies and approaches to screening. A case in point is our recently developed quantitative HTS (qHTS) paradigm, which tests each library compound at multiple concentrations to construct concentration-response curves (CRCs) generating a comprehensive data set for each assay. The practical implementation of qHTS for cell-based and biochemical assays across libraries of > 100,000 compounds (e.g., between 700,000 and 2,000,000 sample wells tested) requires maximal efficiency and miniaturization and the ability to easily accommodate many different assay formats and screening protocols. Here, we describe the design and utilization of a fully integrated and automated screening system for qHTS at the National Institutes of Health's Chemical Genomics Center. We report system productivity, reliability, and flexibility, as well as modifications made to increase throughput, add additional capabilities, and address limitations. The combination of this system and qHTS has led to the generation of over 6 million CRCs from >120 assays in the last 3 years and is a technology that can be widely implemented to increase efficiency of screening and lead generation. JF - Assay and Drug Development Technologies AU - Michael, S AU - Auld, D AU - Klumpp, C AU - Jadhav, A AU - Zheng, W AU - Thorne, N AU - Austin, C P AU - Inglese, J AU - Simeonov, A AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20850, USA, asimeono@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 637 EP - 658 VL - 6 IS - 5 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Data processing KW - robotics KW - high-throughput screening KW - Drug development KW - genomics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19645898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=A+Robotic+Platform+for+Quantitative+High-Throughput+Screening&rft.au=Michael%2C+S%3BAuld%2C+D%3BKlumpp%2C+C%3BJadhav%2C+A%3BZheng%2C+W%3BThorne%2C+N%3BAustin%2C+C+P%3BInglese%2C+J%3BSimeonov%2C+A&rft.aulast=Michael&rft.aufirst=S&rft.date=2008-10-01&rft.volume=6&rft.issue=5&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2008.150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Drug development; high-throughput screening; robotics; Data processing; software; genomics; Computer programs DO - http://dx.doi.org/10.1089/adt.2008.150 ER - TY - JOUR T1 - Transcriptional Correlates of Human Substance Use AN - 19613850; 8647697 AB - Drugs of abuse produce both acute and chronic changes in brain function, each of which is reflected in altered gene expression patterns. A number of large-scale gene expression studies have employed microarray analysis of human postmortem brain to identify transcriptional correlates of antemortem substance use. These studies have identified changes in transcripts encoding proteins functionally involved in neuronal function and synaptic plasticity, oligodendrocyte function and myelination, lipid and energy metabolism, mitochondrial function, oxidative phosphorylation, and cytoskeleton-related signal transduction. Overall, different types of substance use appear to share some of these effects, but there are more differences than similarities in gene expression for different types of substance use. Moreover, data suggest that transcriptional subtypes within a diagnostic classification of substance use may occur. These transcriptional subtypes, or 'endophenotypes,' may reflect complex patterns of substance use and co-morbid neuropsychiatric disorders or other diseases, which may interact with substance use to differentially affect gene expression. A broader understanding of the manner in which substance abuse causes long-term changes in brain function may be obtained from studies replicating and expanding the present gene expression data. In particular, cross-referencing comprehensive transcriptional data on regional and-or substance use-specific changes with genetic and proteomic data may further aid in identifying candidate biomarkers of altered brain function in substance-use disorders. JF - Annals of the New York Academy of Sciences AU - Lehrmann, Elin AU - Freed, William J AD - Cellular Neurobiology Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA, elehrman@intra.nida.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 34 EP - 42 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1139 IS - 1 SN - 0077-8923, 0077-8923 KW - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - alcohol KW - cocaine KW - cannabis KW - gene expression KW - human postmortem brain KW - nicotine KW - RNA KW - substance abuse KW - Oligodendrocytes KW - Lipids KW - Mitochondria KW - Plasticity (synaptic) KW - Drug abuse KW - DNA microarrays KW - Gene expression KW - Mental disorders KW - Bioindicators KW - Data processing KW - Energy metabolism KW - Oxidative phosphorylation KW - substance use KW - Brain KW - Transcription KW - biomarkers KW - Lipid metabolism KW - Proteins KW - proteomics KW - Myelination KW - Metabolism KW - Signal transduction KW - N3 11023:Neurogenetics KW - N 14810:Methods KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19613850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Transcriptional+Correlates+of+Human+Substance+Use&rft.au=Lehrmann%2C+Elin%3BFreed%2C+William+J&rft.aulast=Lehrmann&rft.aufirst=Elin&rft.date=2008-10-01&rft.volume=1139&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1432.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Energy metabolism; Oligodendrocytes; Oxidative phosphorylation; Brain; Transcription; Mitochondria; Drug abuse; Plasticity (synaptic); DNA microarrays; biomarkers; Lipid metabolism; Gene expression; Mental disorders; proteomics; Myelination; Signal transduction; substance abuse; Bioindicators; Lipids; substance use; Proteins; Metabolism DO - http://dx.doi.org/10.1196/annals.1432.027 ER - TY - JOUR T1 - Exercise enhances vaccine-induced antigen-specific T cell responses AN - 19611495; 8618132 AB - Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX enhanced OVA-specific CD4 super(+) T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases. JF - Vaccine AU - Rogers, Connie J AU - Zaharoff, David A AU - Hance, Kenneth W AU - Perkins, Susan N AU - Hursting, Stephen D AU - Schlom, Jeffrey AU - Greiner, John W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, United States, greinerj@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 5407 EP - 5415 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 42 SN - 0264-410X, 0264-410X KW - Physical Education Index; Immunology Abstracts KW - Adaptive immunity KW - Cytokines KW - Cell proliferation KW - Ovalbumin KW - Mucosal immunity KW - Preventive health KW - Running KW - Animal subjects KW - Immune system KW - Animal models KW - Therapy KW - Exercise KW - Vaccination KW - Physical training KW - CD4 antigen KW - Wheel running KW - Lymphocytes T KW - Vaccines KW - Immune response KW - Diseases KW - Self efficacy KW - F 06905:Vaccines KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19611495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Exercise+enhances+vaccine-induced+antigen-specific+T+cell+responses&rft.au=Rogers%2C+Connie+J%3BZaharoff%2C+David+A%3BHance%2C+Kenneth+W%3BPerkins%2C+Susan+N%3BHursting%2C+Stephen+D%3BSchlom%2C+Jeffrey%3BGreiner%2C+John+W&rft.aulast=Rogers&rft.aufirst=Connie&rft.date=2008-10-01&rft.volume=26&rft.issue=42&rft.spage=5407&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.07.081 LA - English DB - Physical Education Index N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Preventive health; Immune system; Animal subjects; Running; Therapy; Diseases; Exercise; Self efficacy; Ovalbumin; CD4 antigen; Mucosal immunity; Wheel running; Animal models; Lymphocytes T; Cytokines; Immune response; Vaccines; Vaccination; Physical training DO - http://dx.doi.org/10.1016/j.vaccine.2008.07.081 ER - TY - JOUR T1 - An intrinsic pattern of reduced susceptibility to fluoroquinolones in pediatric isolates of Streptococcus pyogenes AN - 19608976; 8578538 AB - A total of 116 clinical isolates collected in 2003 from a tertiary pediatric hospital and a primary pediatric department in Chicago, IL, were screened for reduced susceptibility to selected fluoroquinolones by disc diffusion. Correlation between reduced susceptibility and point mutations in the quinolone resistance-determining region of parC and gyrA genes was evaluated, and point mutations were compared with other reports of isolates derived from adult or mixed patient populations. Nine percent of isolates had reduced susceptibility to 1 or more of these fluoroquinolones by Etest: ciprofloxacin, levofloxacin, and moxifloxacin. A single point mutation (Ser-79) in parC seemed responsible for the reduced susceptibility. Resistant Streptococcus pyogenes isolates were compared using M/emm type, repetitive sequence-based PCR (rep-PCR), and pulsed-field gel electrophoresis (PFGE). Rep-PCR provided no more separation of strains than M/emm typing, and PFGE results with SgrAI were more discriminatory than with SmaI. The majority of these isolates were M/emm type 6. PFGE analysis using SgrAI demonstrated 2 different resistant strains among the M/emm type 6 isolates. The findings suggest that a population of S. pyogenes with an intrinsic reduced susceptibility to fluoroquinolones exists in pediatric clinical isolates. Monitoring of amino acid changes in both parC and gyrA will assist in the prediction of emergence of high-level fluoroquinolone resistance. JF - Diagnostic Microbiology and Infectious Disease AU - Yan, S S AU - Schreckenberger, P C AU - Zheng, X AU - Nelson, NA AU - Harrington, S M AU - Tjhio, J AU - Fedorko, D P AD - DHHS, Bethesda, MD 20892, USA, dfedorko@mail.cc.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 205 EP - 209 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 62 IS - 2 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Fluoroquinolones KW - Pediatrics KW - Levofloxacin KW - Quinolones KW - Point mutation KW - Streptococcus pyogenes KW - DNA topoisomerase IV KW - Ciprofloxacin KW - Typing KW - Moxifloxacin KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - Diffusion KW - Hospitals KW - Amino acid sequence KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19608976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=An+intrinsic+pattern+of+reduced+susceptibility+to+fluoroquinolones+in+pediatric+isolates+of+Streptococcus+pyogenes&rft.au=Yan%2C+S+S%3BSchreckenberger%2C+P+C%3BZheng%2C+X%3BNelson%2C+NA%3BHarrington%2C+S+M%3BTjhio%2C+J%3BFedorko%2C+D+P&rft.aulast=Yan&rft.aufirst=S&rft.date=2008-10-01&rft.volume=62&rft.issue=2&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2008.04.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Fluoroquinolones; Pediatrics; Levofloxacin; Point mutation; Quinolones; DNA topoisomerase IV; Ciprofloxacin; Typing; Moxifloxacin; Pulsed-field gel electrophoresis; Polymerase chain reaction; Diffusion; Amino acid sequence; Hospitals; Streptococcus pyogenes DO - http://dx.doi.org/10.1016/j.diagmicrobio.2008.04.018 ER - TY - JOUR T1 - Is Addressing Impairments the Shortest Path to Improving Function? AN - 19595837; 8880837 AB - As a result of the International Classification of Functioning (ICF), Disability and Health (World Health Organization, 2001), physical and occupational therapy practitioners and researchers now recognize that any treatment approach for individuals with cerebral palsy (CP) and other motor disabilities should be chosen or developed with consideration of its potential broader impact on the patient's or client's level of activity and participation (Rosenbaum & Stewart, 2004). However, for many years we mistakenly assumed that treating impairments, or limitations in specific body structures or functions, would lead directly and perhaps even proportionately to functional improvement. Confidence in this assumption was slowly eroded as treatments were developed that successfully eliminated what were deemed primary impairments, but function changed minimally in comparison (e.g. meta-analysis of outcomes in selective dorsal rhizotomy for spastic CP showed consistent large changes in spasticity with modest or negligible changes in function) (McLaughlin et al., 2002). In multiple studies relating impairments in either the upper or lower extremity to motor performance, few have emerged as significant and strong predictors of function (Abel et al., 2003; Beckung & Hagberg, 2002). As is apparent in the ICF, personal and environmental factors also interact in a reciprocal, rather than unidirectional, relationship between impairments in body structures and functions and activity limitations, which further weakens the predictability of one from the other. Finally, dynamical systems theory emphasizes the complexity and nonlinearity of producing a change in function, such that a small change in a single key rate-limiting parameter could produce a marked change in behavior whereas a large change in another parameter might go unnoticed (Kamm, Thelen, & Jensen, 1990). JF - Physical & Occupational Therapy in Pediatrics AU - Damiano, D L AD - Biomechanics Program, Rehabilitation Medicine Department, National Institutes of Health Clinical Center Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 325 EP - 328 VL - 28 IS - 4 SN - 0194-2638, 0194-2638 KW - Physical Education Index KW - Confidence KW - Handicapped KW - Classification KW - Physical therapy KW - Health (organization) KW - Meta analysis KW - Cerebral palsy KW - Legs KW - Spasticity KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19595837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+%26+Occupational+Therapy+in+Pediatrics&rft.atitle=Is+Addressing+Impairments+the+Shortest+Path+to+Improving+Function%3F&rft.au=Damiano%2C+D+L&rft.aulast=Damiano&rft.aufirst=D&rft.date=2008-10-01&rft.volume=28&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Physical+%26+Occupational+Therapy+in+Pediatrics&rft.issn=01942638&rft_id=info:doi/10.1080%2F01942630802307077 LA - English DB - Physical Education Index N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Handicapped; Health (organization); Physical therapy; Cerebral palsy; Spasticity; Classification; Legs; Meta analysis; Confidence DO - http://dx.doi.org/10.1080/01942630802307077 ER - TY - JOUR T1 - Inhibition of the development of morphine tolerance by a potent dual k-/d-opioid antagonist, H-Dmt-Tic-Lys-NH-CH sub(2)-Ph AN - 19571332; 8835235 AB - Three analogues of the dual k-/d-antagonist, H-Dmt-Tic-R-NH-CH sub(2)-Ph (R=1, Lys-Z; 2, Lys-Ac; 3, Lys) were examined in vivo: 1 and 2 exhibited weak bioactivity, while 3 injected intracerebroventricularly was a potent dual antagonist for morphine- and deltorphin C-induced antinociception comparable to naltrindole (d-antagonist), but 93% as effective as naloxone (nonspecific opioid receptor antagonist) and 4% as active as CTOP, a k antagonist. Subcutaneous or oral administration of 3 antagonized morphine-induced antinociception indicating passage across epithelial and blood-brain barriers. Mice pretreated with 3 before morphine did not develop morphine tolerance indicative of a potential clinical role to inhibit development of drug tolerance. JF - Pharmacology Biochemistry and Behavior AU - Jinsmaa, Y AU - Marczak, ED AU - Balboni, G AU - Salvadori, S AU - Lazarus, L H AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA, marczake@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 651 EP - 657 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 90 IS - 4 SN - 0091-3057, 0091-3057 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Opioid receptors KW - Morphine KW - Naltrindole KW - Blood-brain barrier KW - Pain perception KW - Oral administration KW - Drug tolerance KW - Naloxone KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19571332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Inhibition+of+the+development+of+morphine+tolerance+by+a+potent+dual+k-%2Fd-opioid+antagonist%2C+H-Dmt-Tic-Lys-NH-CH+sub%282%29-Ph&rft.au=Jinsmaa%2C+Y%3BMarczak%2C+ED%3BBalboni%2C+G%3BSalvadori%2C+S%3BLazarus%2C+L+H&rft.aulast=Jinsmaa&rft.aufirst=Y&rft.date=2008-10-01&rft.volume=90&rft.issue=4&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2Fj.pbb.2008.05.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Opioid receptors; Morphine; Naltrindole; Blood-brain barrier; Oral administration; Pain perception; Drug tolerance; Naloxone DO - http://dx.doi.org/10.1016/j.pbb.2008.05.008 ER - TY - JOUR T1 - The immunity-related GTPase Irgm1 promotes the expansion of activated CD4 super(+) T cell populations by preventing interferon-[gamma]-induced cell death AN - 19564715; 8800130 AB - Mice deficient in the interferon-[gamma] (IFN-[gamma])-inducible, immunity-related GTPase Irgm1 have defective host resistance to a variety of intracellular pathogens. This greater susceptibility to infection is associated with impaired IFN-[gamma]-dependent macrophage microbicidal activity in vitro. Here we show that Irgm1 also regulated the survival of mature effector CD4 super(+) T lymphocytes by protecting them from IFN-[gamma]- induced autophagic cell death. Mice deficient in both IFN-[gamma] and Irgm1 were 'rescued' from the lymphocyte depletion and greater mortality that occurs in mice singly deficient in Irgm1 after mycobacterial infection. Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-[gamma] on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-[gamma]. JF - Nature Immunology AU - Feng, Carl G AU - Zheng, Lixin AU - Jankovic, Dragana AU - Bafica, Andre AU - Cannons, Jennifer L AU - Watford, Wendy T AU - Chaussabel, Damien AU - Hieny, Sara AU - Caspar, Patricia AU - Schwartzberg, Pamela L AU - Lenardo, Michael J AU - Sher, Alan Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1279 EP - 1287 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 9 IS - 11 SN - 1529-2908, 1529-2908 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell survival KW - Macrophages KW - Mortality KW - Mycobacterium KW - Pathogens KW - Infection KW - Cell death KW - CD4 antigen KW - Lymphocytes T KW - Feedback KW - Guanosinetriphosphatase KW - microbicides KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19564715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Immunology&rft.atitle=The+immunity-related+GTPase+Irgm1+promotes+the+expansion+of+activated+CD4+super%28%2B%29+T+cell+populations+by+preventing+interferon-%5Bgamma%5D-induced+cell+death&rft.au=Feng%2C+Carl+G%3BZheng%2C+Lixin%3BJankovic%2C+Dragana%3BBafica%2C+Andre%3BCannons%2C+Jennifer+L%3BWatford%2C+Wendy+T%3BChaussabel%2C+Damien%3BHieny%2C+Sara%3BCaspar%2C+Patricia%3BSchwartzberg%2C+Pamela+L%3BLenardo%2C+Michael+J%3BSher%2C+Alan&rft.aulast=Feng&rft.aufirst=Carl&rft.date=2008-10-01&rft.volume=9&rft.issue=11&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Nature+Immunology&rft.issn=15292908&rft_id=info:doi/10.1038%2Fni.1653 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell survival; Mortality; CD4 antigen; Cell death; Lymphocytes T; Feedback; Pathogens; Infection; microbicides; Guanosinetriphosphatase; Mycobacterium DO - http://dx.doi.org/10.1038/ni.1653 ER - TY - JOUR T1 - Kinesthetic Imagery and Tool-Specific Modulation of Corticospinal Representations in Expert Tennis Players AN - 19504362; 8560385 AB - Specific physical or mental practice may induce short- and long-term neuroplastic changes in the motor system and cause tools to become part of one's own body representation. Athletes who use tools as part of their practice may be an excellent model for assessing the neural correlates of possible bodily representation changes that are specific to extensive practice. We used single-pulse transcranial magnetic stimulation to measure corticospinal excitability in forearm and hand muscles of expert tennis players and novices while they mentally practiced a tennis forehand, table tennis forehand, and a golf drive. The muscles of expert tennis players showed increased corticospinal facilitation during motor imagery of tennis but not golf or table tennis. Novices, although athletes, were not modulated across sports. Subjective reports indicated that only in the tennis imagery condition did experts differ from novices in the ability to form proprioceptive images and to consider the tool as an extension of the hand. Neurophysiological and subjective data converge to suggest a key role of long-term experience in modulating sensorimotor body representations during mental simulation of sports. JF - Cerebral Cortex AU - Fourkas, Alissa D AU - BonavolontA, Valerio AU - Avenanti, Alessio AU - Aglioti, Salvatore M AD - 1 Dipartimento di Psicologia, UniversitA degli studi di Roma 'La Sapienza,' I-00185 Roma, Italia,; fourkasa@mail.nih.gov] alissa-dora.fourkas@uni-tuebingen.de Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 2382 EP - 2390 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 18 IS - 10 SN - 1047-3211, 1047-3211 KW - CSA Neurosciences Abstracts; Physical Education Index KW - Hands KW - Excitability KW - Practice KW - Sports KW - sensorimotor system KW - Cortex KW - Pyramidal tracts KW - Motor systems KW - Mental practice KW - mental task performance KW - Forearm KW - Data processing KW - Motor task performance KW - Muscles KW - Hand KW - Table tennis KW - Physical training KW - Transcranial magnetic stimulation KW - Golf (swing) KW - Proprioception KW - Tennis (players) KW - Athletes KW - N3 11002:Computational & theoretical neuroscience KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19504362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cerebral+Cortex&rft.atitle=Kinesthetic+Imagery+and+Tool-Specific+Modulation+of+Corticospinal+Representations+in+Expert+Tennis+Players&rft.au=Fourkas%2C+Alissa+D%3BBonavolontA%2C+Valerio%3BAvenanti%2C+Alessio%3BAglioti%2C+Salvatore+M&rft.aulast=Fourkas&rft.aufirst=Alissa&rft.date=2008-10-01&rft.volume=18&rft.issue=10&rft.spage=2382&rft.isbn=&rft.btitle=&rft.title=Cerebral+Cortex&rft.issn=10473211&rft_id=info:doi/10.1093%2Fcercor%2Fbhn005 LA - English DB - Physical Education Index N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Athletes; Mental practice; Tennis (players); Golf (swing); Muscles; Sports; Practice; Hands; Table tennis; Pyramidal tracts; Physical training; Hand; Transcranial magnetic stimulation; Data processing; Motor task performance; sensorimotor system; Excitability; Forearm; Motor systems; Proprioception; mental task performance; Cortex DO - http://dx.doi.org/10.1093/cercor/bhn005 ER - TY - JOUR T1 - On the spread of epidemics in a closed heterogeneous population AN - 19503524; 8811035 AB - Heterogeneity is an important property of any population experiencing a disease. Here we apply general methods of the theory of heterogeneous populations to the simplest mathematical models in epidemiology. In particular, an SIR (susceptible-infective-removed) model is formulated and analyzed when susceptibility to or infectivity of a particular disease is distributed. It is shown that a heterogeneous model can be reduced to a homogeneous model with a nonlinear transmission function, which is given in explicit form. The widely used power transmission function is deduced from the model with distributed susceptibility and infectivity with the initial gamma-distribution of the disease parameters. Therefore, a mechanistic derivation of the phenomenological model, which is believed to mimic reality with high accuracy, is provided. The equation for the final size of an epidemic for an arbitrary initial distribution of susceptibility is found. The implications of population heterogeneity are discussed, in particular, it is pointed out that usual moment-closure methods can lead to erroneous conclusions if applied for the study of the long-term behavior of the models. JF - Mathematical Biosciences AU - Novozhilov, Artem S AD - National Institutes of Health, NCBI, 8600 Rockville Pike, Bldg 38A room 8N811H, Bethesda, MD 20894, USA, novozhil@ncbi.nlm.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 177 EP - 185 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 215 IS - 2 SN - 0025-5564, 0025-5564 KW - Ecology Abstracts; Biotechnology and Bioengineering Abstracts KW - Infectivity KW - Epidemics KW - Mathematical models KW - Epidemiology KW - W 30910:Imaging KW - D 04030:Models, Methods, Remote Sensing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19503524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mark%3A+another+architecture&rft.atitle=Populous+doesn%27t+mind+the+weather+%5BMiami%2C+Florida%5D.&rft.au=Schaefer%2C+Silvie&rft.aulast=Schaefer&rft.aufirst=Silvie&rft.date=2012-10-01&rft.volume=&rft.issue=40&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Mark%3A+another+architecture&rft.issn=15746453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mathematical models; Infectivity; Epidemics; Epidemiology DO - http://dx.doi.org/10.1016/j.mbs.2008.07.010 ER - TY - JOUR T1 - Androgen receptor expression in prostate cancer stem cells: is there a conundrum? AN - 19479177; 8410718 AB - Androgen deprivation therapy (ADT) is standard frontline therapy for metastatic prostate cancer. However, prostate cancer progresses to a castrate-resistant state. The response of prostate cancer to androgen deprivation is mediated by the androgen receptor (AR). Castrate-resistant disease is marked by a gain-of-function in AR and AR reactivation. The stem cell hypothesis of cancer would therefore predict that AR should be expressed in the prostate cancer stem cell, since genetic selection for gain-of-function changes in AR, such as AR gene amplification, should occur at the level of the stem cell population. Initial reports characterizing prostate cancer stem cells suggest that AR is not expressed in this population, which is an apparent conundrum. Here, we examined the CD44+/24- LNCaP putative stem cell population by in-cell Western and show that AR is expressed at the protein level. Our findings suggest that at least a subset of prostate cancers express AR in the putative stem cell population. JF - Cancer Chemotherapy and Pharmacology AU - Sharifi, Nima AU - Hurt, Elaine M AU - Farrar, William L AD - National Cancer Institute Frederick, Frederick, MD, 21702, USA, galanthus7@yahoo.com Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 921 EP - 923 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 62 IS - 5 SN - 0344-5704, 0344-5704 KW - Biotechnology and Bioengineering Abstracts KW - Androgen receptors KW - Metastases KW - Stem cells KW - Prostate cancer KW - Androgens KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19479177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mark%3A+another+architecture&rft.atitle=Populous+doesn%27t+mind+the+weather+%5BMiami%2C+Florida%5D.&rft.au=Schaefer%2C+Silvie&rft.aulast=Schaefer&rft.aufirst=Silvie&rft.date=2012-10-01&rft.volume=&rft.issue=40&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Mark%3A+another+architecture&rft.issn=15746453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Metastases; Androgen receptors; Stem cells; Prostate cancer; Androgens DO - http://dx.doi.org/10.1007/s00280-007-0659-5 ER - TY - JOUR T1 - Differential Sorting of Human Parathyroid Hormone After Transduction of Mouse and Rat Salivary Glands AN - 19410054; 8759280 AB - Gene transfer to salivary glands leads to abundant secretion of transgenic protein into either saliva or the bloodstream. This indicates significant clinical potential, depending on the route of sorting. The aim of this study was to probe the sorting characteristics of human parathyroid hormone (hPTH) in two animal models for salivary gland gene transfer. PTH is a key hormone regulating calcium levels in the blood. A recombinant serotype 5 adenoviral vector carrying the hPTH cDNA was administered to the submandibular glands of mice and rats. Two days after delivery, high levels of hPTH were found in the serum of mice, leading to elevated serum calcium levels. Only low amounts of hPTH were found in the saliva. Two days after vector infusion into rats, a massive secretion of hPTH was measured in saliva, with little secretion into serum. Confocal microscopy showed hPTH in the glands, localized basolaterally in mice and apically in rats. Submandibular gland transduction was effective and the produced hPTH was biologically active in vivo. Whereas hPTH sorted toward the basolateral side in mice, in rats hPTH was secreted mainly at the apical side. These results indicate that the interaction between hPTH and the cell sorting machinery is different between mouse and rat salivary glands. Detailed studies in these two species should result in a better understanding of cellular control of transgenic secretory protein sorting in this tissue. JF - Human Gene Therapy AU - Adriaansen, J AU - Perez, P AU - Goldsmith, C M AU - Zheng, C AU - Baum, B J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Building 10, Room 1N113, MSC-1190, 10 Center Drive, Bethesda, MD 20892-1190, USA, adriaansenj@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1021 EP - 1028 VL - 19 IS - 10 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Protein transport KW - Calcium KW - Serotypes KW - Gene therapy KW - Secretion KW - Animal models KW - Probes KW - Salivary gland KW - Hormones KW - Calcium (blood) KW - Expression vectors KW - Blood KW - Confocal microscopy KW - Parathyroid hormone KW - Submandibular gland KW - Saliva KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19410054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Differential+Sorting+of+Human+Parathyroid+Hormone+After+Transduction+of+Mouse+and+Rat+Salivary+Glands&rft.au=Adriaansen%2C+J%3BPerez%2C+P%3BGoldsmith%2C+C+M%3BZheng%2C+C%3BBaum%2C+B+J&rft.aulast=Adriaansen&rft.aufirst=J&rft.date=2008-10-01&rft.volume=19&rft.issue=10&rft.spage=1021&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein transport; Serotypes; Calcium; Gene therapy; Secretion; Probes; Animal models; Salivary gland; Calcium (blood); Hormones; Expression vectors; Blood; Confocal microscopy; Parathyroid hormone; Submandibular gland; Saliva DO - http://dx.doi.org/10.1089/hum.2008.079 ER - TY - JOUR T1 - Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: The Generation R study AN - 19377858; 8559788 AB - Concern about potential health impacts of low-level exposures to organophosphorus (OP) pesticides, bisphenol A (BPA), and phthalates among the general population is increasing. We measured levels of six dialkyl phosphate (DAP) metabolites of OP pesticides, a chlorpyrifos-specific metabolite (3,5,6-trichloro-2-pyridinol, TCPy), BPA, and 14 phthalate metabolites in urine samples of 100 pregnant women from the Generation R study, the Netherlands. The unadjusted and creatinine-adjusted concentrations were reported, and compared to National Health and Nutrition Examination Survey and other studies. In general, these metabolites were detectable in the urine of the women from the Generation R study and compared with other groups, they had relatively high-level exposures to OP pesticides and several phthalates but similar exposure to BPA. The median concentrations of total dimethyl (DM) metabolites was 264.0nmol/g creatinine (Cr) and of total DAP was 316.0nmol/g Cr. The median concentration of mono-ethyl phthalate (MEP) was 222.0kg /g Cr; the median concentrations of mono-isobutyl phthalate (MiBP) and mono-n-butyl phthalate (MnBP) were above 50kg/g Cr. The median concentrations of the three secondary metabolites of di-2-ethylhexyl phthalate (DEHP) were greater than 20kg/g Cr. The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation. JF - Environmental Research AU - Ye, X AU - Pierik, F H AU - Hauser, R AU - Duty, S AU - Angerer, J AU - Park, M M AU - Burdorf, A AU - Hofman, A AU - Jaddoe, VWV AU - Mackenbach, J P AU - Steegers, EAP AU - Tiemeier, H AU - Longnecker, M P AD - National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), MD A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA, longnec1@niehs.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 260 EP - 267 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 108 IS - 2 SN - 0013-9351, 0013-9351 KW - Pollution Abstracts; Toxicology Abstracts KW - secondary metabolites KW - Metabolites KW - Nutrition KW - Bisphenol A KW - Netherlands KW - bisphenol A KW - Data processing KW - Netherlands, Rotterdam KW - Population studies KW - Phthalic acid KW - Pregnancy KW - phthalates KW - Phosphates KW - Creatinine KW - Phosphate KW - Urine KW - Pesticides KW - Secondary metabolites KW - Females KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19377858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Urinary+metabolite+concentrations+of+organophosphorous+pesticides%2C+bisphenol+A%2C+and+phthalates+among+pregnant+women+in+Rotterdam%2C+the+Netherlands%3A+The+Generation+R+study&rft.au=Ye%2C+X%3BPierik%2C+F+H%3BHauser%2C+R%3BDuty%2C+S%3BAngerer%2C+J%3BPark%2C+M+M%3BBurdorf%2C+A%3BHofman%2C+A%3BJaddoe%2C+VWV%3BMackenbach%2C+J+P%3BSteegers%2C+EAP%3BTiemeier%2C+H%3BLongnecker%2C+M+P&rft.aulast=Ye&rft.aufirst=X&rft.date=2008-10-01&rft.volume=108&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2008.07.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bisphenol A; Data processing; Creatinine; Phosphate; Urine; Pesticides; Population studies; Secondary metabolites; Metabolites; Nutrition; Pregnancy; Phthalic acid; phthalates; bisphenol A; Phosphates; secondary metabolites; Females; Netherlands, Rotterdam; Netherlands DO - http://dx.doi.org/10.1016/j.envres.2008.07.014 ER - TY - JOUR T1 - The effects of age on medio-lateral stability during normal and narrow base walking AN - 19371657; 8768759 AB - We examined age-related differences in frontal plane stability during performance of narrow base (NB) walking relative to usual gait. A cross- sectional analysis of participants from the Baltimore Longitudinal Study of Aging (BLSA) was performed on data from the BLSA Motion Analysis Laboratory. Participants were 34 adults aged 54-92 without history of falls. We measured step error rates during NB gait and spatial-temporal parameters, frontal plane stability, and gait variability during usual and NB gait. There was a non-significant age-associated linear increase in step error rate (P = 0.12) during NB gait. With increasing age, step width increased (P = 0.002) and step length and stride velocity decreased (P < 0.001), especially during NB gait. Age-associated increases in medio-lateral (M-L) center of mass (COM) peak velocity (P < 0.001) and displacement (P = 0.005) were also greater during NB compared to usual gait. With increasing age there was greater variability in stride velocity (P = 0.001) and step length (P < 0.001) under both conditions. Age-associated differences related to M-L COM stability suggest that the quantification of COM control during NB gait may improve identification of older persons at increased falls risk. JF - Gait & Posture AU - Schrager, Matthew A AU - Kelly, Valerie E AU - Price, Robert AU - Ferrucci, Luigi AU - Shumway-Cook, Anne AD - Clinical Research Branch, National Institute on Aging - National Institutes of Health, Harbor Hospital Center, 5th Floor, 3001 S. Hanover Street, Baltimore, MD 21225, United States, schrag17@ku.edu Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 466 EP - 471 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 28 IS - 3 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Longitudinal studies KW - Measurement KW - Analysis KW - Walking KW - Velocity KW - Center of gravity KW - Performance KW - Stability KW - Gait KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19371657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=The+effects+of+age+on+medio-lateral+stability+during+normal+and+narrow+base+walking&rft.au=Schrager%2C+Matthew+A%3BKelly%2C+Valerie+E%3BPrice%2C+Robert%3BFerrucci%2C+Luigi%3BShumway-Cook%2C+Anne&rft.aulast=Schrager&rft.aufirst=Matthew&rft.date=2008-10-01&rft.volume=28&rft.issue=3&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2008.02.009 LA - English DB - Physical Education Index N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Gait; Stability; Velocity; Analysis; Walking; Center of gravity; Longitudinal studies; Performance; Measurement DO - http://dx.doi.org/10.1016/j.gaitpost.2008.02.009 ER - TY - JOUR T1 - Serotonin (5-HT) Transporter Ligands Affect Plasma 5-HT in Rats AN - 19338674; 8647711 AB - Dual dopamine (DA)-serotonin (5-HT)-releasing agents are promising candidate medications for stimulant addiction and other disorders. However, certain 5-HT transporter (SERT) substrates are associated with development of idiopathic pulmonary arterial hypertension (IPAH) and valvular heart disease (VHD). According to the '5-HT hypothesis,' SERT substrates increase the risk for developing IPAH and VHD by increasing plasma 5-HT. To test this hypothesis directly, we determined the effects of acute and chronic fenfluramine, and other SERT ligands, on plasma 5-HT in male rats. For acute treatments, rats received i.v. vehicle or test drug (0.3 and 1.0 mg-kg), and serial blood samples were withdrawn. For chronic treatments, vehicle or test drug was infused via osmotic minipump (3 and 10 mg-kg-d) for 2 weeks. On the last day of infusion, rats received i.v. fenfluramine challenge (1 mg-kg), and serial blood samples were withdrawn. Plasma 5-HT was measured using ex vivo microdialysis in whole-blood samples. Baseline plasma 5-HT was <1.0 nM. Acute injection of fenfluramine or other SERT substrates caused large (up to 24-fold) dose-dependent increases in plasma 5-HT. Chronic fenfluramine at 3 and 10 mg-kg-d produced 1.7- and 3.5-fold increases in baseline plasma 5-HT, while chronic fluoxetine had no effect. Chronic infusions of fenfluramine or fluoxetine diminished the ability of acute fenfluramine to elevate dialysate 5-HT, and both drugs markedly reduced whole-blood 5-HT. Acute fenfluramine increases plasma 5-HT to concentrations that are below the micromolar levels necessary to produce adverse cardiovascular effects. Chronic fenfluramine and fluoxetine have minimal effects on plasma 5-HT, suggesting that the increased risk for IPAH associated with fenfluramine does not depend upon elevations in plasma 5-HT. JF - Annals of the New York Academy of Sciences AU - Rothman, Richard B AU - Zolkowska, Dorota AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland, USA, rrothman@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 268 EP - 284 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1139 IS - 1 SN - 0077-8923, 0077-8923 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19338674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Serotonin+%285-HT%29+Transporter+Ligands+Affect+Plasma+5-HT+in+Rats&rft.au=Rothman%2C+Richard+B%3BZolkowska%2C+Dorota%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2008-10-01&rft.volume=1139&rft.issue=1&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1432.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1196/annals.1432.042 ER - TY - JOUR T1 - Dual DAT/[sigma]1 receptor ligands based on 3-(4-(3-(bis(4- fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol AN - 19332060; 8686047 AB - Ester analogs of (+/-)3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin- 1-yl)-1-phenylpropan-1-ol were synthesized and evaluated for binding at DAT, SERT, NET, and [sigma]1 receptors, and compared to GBR 12909 and several known [sigma]1 receptor ligands. Most of these compounds demonstrated high affinity (K sub(i) = 4.3-51 nM) and selectivity for the DAT among the monoamine transporters. S- and R-1-(4-(3-(bis(4- fluorophenyl)amino)propyl)piperazin-1-yl)-3-phenylpropan-2-ol were also prepared wherein modest enantioselectivity was demonstrated at the DAT. However, no enantioselectivity at [sigma]1 receptors was observed and most of the ester analogs of the more active S-enantiomer showed comparable binding affinities at both DAT and [sigma]1 receptors with a maximal 16-fold DAT/[sigma]1 selectivity. JF - Bioorganic and Medicinal Chemistry AU - Cao, Jianjing AU - Kopajtic, Theresa AU - Katz, Jonathan L AU - Newman, Amy Hauck AD - Medicinal Chemistry Section, National Institute on Drug Abuse--Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA, anewman@intra.nida.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 5238 EP - 5241 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 19 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Enantiomers KW - Monoamine transporter KW - Esters KW - Serotonin transporter KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19332060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Dual+DAT%2F%5Bsigma%5D1+receptor+ligands+based+on+3-%284-%283-%28bis%284-+fluorophenyl%29amino%29propyl%29piperazin-1-yl%29-1-phenylpropan-1-ol&rft.au=Cao%2C+Jianjing%3BKopajtic%2C+Theresa%3BKatz%2C+Jonathan+L%3BNewman%2C+Amy+Hauck&rft.aulast=Cao&rft.aufirst=Jianjing&rft.date=2008-10-01&rft.volume=18&rft.issue=19&rft.spage=5238&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2008.08.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Enantiomers; Monoamine transporter; Serotonin transporter; Esters DO - http://dx.doi.org/10.1016/j.bmcl.2008.08.065 ER - TY - JOUR T1 - Validation of proteomic-based discovery with tissue microarrays AN - 19285459; 8640592 AB - Proteomics is routinely utilized for biomarker discovery above and beyond its general use in basic science. Multiple platforms provide a robust pipeline of candidates that require verification and validation as biomarkers of disease. Within the field of oncology, tissue biomarkers are in high demand as tools of diagnosis, prognosis and prediction of response to therapy. By examining the proteome, rather than the transcriptome, there is the potential to directly interrogate the drug targets and define biomarkers at the most proximate level. Toward these ends, the tissue microarray has become a common platform for verification of results and validation of clinically relevant biomarkers. Immunohistochemistry remains the most common analytical method applied to TMA and provides a direct channel toward clinical application. The TMA stands at the crossroads of proteomics and pathology, combining formalin-fixed paraffin-embedded tissue as an analyte and IHC as a method of assay. JF - Proteomics Clinical Applications AU - Hewitt, S M AU - Takikita, M AU - Abedi-Ardekani, B AU - Kris, Y AU - Bexfield, K AU - Braunschweig, T AU - Chung, J-Y AD - TARP Lab, Advanced Technology Center, MSC 4605, Bethesda, MD 20892-4605, USA, genejock@helix.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1460 EP - 1466 VL - 2 IS - 10-11 SN - 1862-8346, 1862-8346 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Prognosis KW - Therapeutic applications KW - Oncology KW - proteomics KW - biomarkers KW - Immunohistochemistry KW - Drugs KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19285459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Validation+of+proteomic-based+discovery+with+tissue+microarrays&rft.au=Hewitt%2C+S+M%3BTakikita%2C+M%3BAbedi-Ardekani%2C+B%3BKris%2C+Y%3BBexfield%2C+K%3BBraunschweig%2C+T%3BChung%2C+J-Y&rft.aulast=Hewitt&rft.aufirst=S&rft.date=2008-10-01&rft.volume=2&rft.issue=10-11&rft.spage=1460&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200800003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Prognosis; Therapeutic applications; Oncology; proteomics; Drugs; Immunohistochemistry; biomarkers DO - http://dx.doi.org/10.1002/prca.200800003 ER - TY - JOUR T1 - Analysis of biofluids for biomarker research AN - 19284885; 8640587 AB - While many of the developments made in high-throughput proteomics were originally applied to procaryotic and simple eucaryotic organisms, the analysis of biofluids became increasingly important as the prospect of using proteomics to discover novel biomarkers became realized. Biofluids have represented a unique challenge to proteomics as they are often present only in small amounts and, particularly in the cases of serum and plasma, can have protein concentration ranges that differ by ten orders of magnitude. While the discovery of authentic, clinically useful biomarkers in the proteomics era has been lacking, there have been a number of significant developments in the ability to more comprehensively characterize biofluid proteomes. The rapid pace of these developments suggest that the eventual discovery of clinically validate biomarkers using proteomic technologies still has a bright future. JF - Proteomics Clinical Applications AU - Xu, X AU - Veenstra, T D AD - Laboratory of Prote-omics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, P.O. Box B, Frederick, MD, USA, veenstra@ncifcrf.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1403 EP - 1412 VL - 2 IS - 10-11 SN - 1862-8346, 1862-8346 KW - Biotechnology and Bioengineering Abstracts KW - Therapeutic applications KW - proteomics KW - biomarkers KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19284885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Analysis+of+biofluids+for+biomarker+research&rft.au=Xu%2C+X%3BVeenstra%2C+T+D&rft.aulast=Xu&rft.aufirst=X&rft.date=2008-10-01&rft.volume=2&rft.issue=10-11&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200780173 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Therapeutic applications; proteomics; biomarkers DO - http://dx.doi.org/10.1002/prca.200780173 ER - TY - JOUR T1 - Bringing diagnostic technologies to the clinical laboratory: Rigor, regulation, and reality AN - 19284863; 8640585 AB - With the numerous reports of new technologies and biomarkers reported in the literature, it may be surprising that there are not an equal number of new products available to the clinical diagnostic laboratory. Powerful potential tools such as protein microarrays and MS patterns have been extensively published yet commercialization and acceptance of these technologies has yet to happen. The reasons for this are a combination of industry risk avoidance, academic focus on discovery, and a lack of appreciation for the high standards and regulation that surrounds the clinical diagnostic laboratory. The development and validation of a new technology or biomarker ensures that a test is reproducible, controllable, and has a defined accuracy and clinical predictive result but this information is only obtained through somewhat mundane but necessary experimental work. The use of design of experiment principles helps to define material parameters to ensure performance. The organization and documentation of this work through a quality system is both mandated and practical. All of this must be done before a test can reach the market with the safety and effectiveness review of regulatory agencies. JF - Proteomics Clinical Applications AU - Whiteley, G AD - Clinical Proteomics Reference Lab, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, P.O. Box B, Frederick, MD 21702-1201, USA, whiteleyg@ncifcrf.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1378 EP - 1385 VL - 2 IS - 10-11 SN - 1862-8346, 1862-8346 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Protein arrays KW - Therapeutic applications KW - proteomics KW - biomarkers KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19284863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Bringing+diagnostic+technologies+to+the+clinical+laboratory%3A+Rigor%2C+regulation%2C+and+reality&rft.au=Whiteley%2C+G&rft.aulast=Whiteley&rft.aufirst=G&rft.date=2008-10-01&rft.volume=2&rft.issue=10-11&rft.spage=1378&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200780170 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Reviews; Protein arrays; Therapeutic applications; proteomics; biomarkers DO - http://dx.doi.org/10.1002/prca.200780170 ER - TY - JOUR T1 - A well-based reverse-phase protein array applicable to extracts from formalin-fixed paraffin-embedded tissue AN - 19284451; 8640599 AB - Proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tissue offers significant diagnostic utility but is complicated due to the high level of covalently crosslinked proteins arising from formalin fixation. To address these challenges, we developed a reliable protein extraction method for FFPE tissue, based on heat-induced antigen retrieval within a pressure cooker. The protein extraction yield from archival FFPE tissue section is approximately 90% of that recovered from frozen tissue. This method demonstrates preservation of immunoreactivity and recovery of full-length proteins by Western blotting. Additionally, we developed a well-based RP protein array platform utilizing an electrochemiluminescence detection system. Protein samples derived from FFPE tissue by means of laser capture dissection, with as few as 500 shots demonstrate measurable signal differences for different proteins. The lysates coated to the array plate, remain stable over 1 month at room temperature. Theses data suggest that this new protein-profiling platform coupled with the protein extraction method can be used for molecular profiling analysis in FFPE tissue, and contribute to the validation and development of biomarkers in clinical studies. JF - Proteomics Clinical Applications AU - Chung, J-Y AU - Lee, S-J AU - Kris, Y AU - Braunschweig, T AU - Traicoff, J L AU - Hewitt, S M AD - TARP Laboratory, Advanced Technology Center, MSC 4605, Bethesda, MD 20892-4605, USA, genejock@helix.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1539 EP - 1547 VL - 2 IS - 10-11 SN - 1862-8346, 1862-8346 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Western blotting KW - Data processing KW - Therapeutic applications KW - Formaldehyde KW - biomarkers KW - Protein arrays KW - Immunoreactivity KW - Lasers KW - proteomics KW - Preservation KW - Pressure KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19284451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=A+well-based+reverse-phase+protein+array+applicable+to+extracts+from+formalin-fixed+paraffin-embedded+tissue&rft.au=Chung%2C+J-Y%3BLee%2C+S-J%3BKris%2C+Y%3BBraunschweig%2C+T%3BTraicoff%2C+J+L%3BHewitt%2C+S+M&rft.aulast=Chung&rft.aufirst=J-Y&rft.date=2008-10-01&rft.volume=2&rft.issue=10-11&rft.spage=1539&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200800005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Western blotting; Data processing; Immunoreactivity; Protein arrays; Formaldehyde; Therapeutic applications; Lasers; Preservation; proteomics; Pressure; biomarkers DO - http://dx.doi.org/10.1002/prca.200800005 ER - TY - JOUR T1 - Mechanoactive Tenogenic Differentiation of Human Mesenchymal Stem Cells AN - 19283680; 8690285 AB - A mesenchymal stem cell (MSC)-seeded collagen gel under static or dynamic tension is a well-established model to study the potential of MSCs in regenerating a tendon- or ligament-like tissue. Using this model, upregulation of fibrillar collagen mRNA expression and protein production has been demonstrated in response to cyclic tensile mechanical stimulation. However, the mechanisms driving MSC tenogenesis (differentiation into tendon or ligament fibroblasts) have not been elucidated. This study investigated the mechanisms of tenogenesis of human bone marrow-derived MSCs in a dynamic, three-dimensional (3D) tissue-engineering model by investigating the effects of cyclic stretching on matrix production and gene expression of candidate tendon and ligament markers. The 3D MSC tenogenesis culture system upre-gulated scleraxis, but cyclic stretching was required to maintain expression of this putative tendon marker over time. Enhanced tendinous neo-tissue development demonstrated with extracellular matrix staining was largely due to changes in matrix deposition and remodeling activity under dynamic loading conditions, as evidenced by differential regulation of matrix metalloproteinases at a transcriptional level with minimal changes in collagen mRNA levels. Regulation of Wnt gene expression with cyclic stimulation suggested a similar role for Wnt4 versus Wnt5a in tenogenesis as in cartilage development. This first report of the potential involvement of matrix remodeling and Wnt signaling during tenogenesis of human MSCs in a dynamic, 3D tissue-engineering model provides insights into the mechanisms of tenogenesis in a mechanoactive environment and supports the therapeutic potential of adult stem cells. JF - Tissue Engineering, Part A: Tissue Engineering AU - Kuo, C K AU - Tuan, R S AD - Cartilage Biology and Orthopedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1523, 50 South Drive, MSC 8022, Bethesda, MD 20892, USA, Tuanr@mail.nih.gov Y1 - 2008/10// PY - 2008 DA - Oct 2008 SP - 1615 EP - 1628 VL - 14 IS - 10 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Mechanical loading KW - Ligaments KW - Wnt protein KW - Cartilage KW - Bone marrow KW - Transcription KW - Matrix metalloproteinase KW - Tissue engineering KW - Mechanical stimuli KW - Fibroblasts KW - Collagen KW - Gene expression KW - Differentiation KW - Stem cells KW - Extracellular matrix KW - Mesenchyme KW - Tendons KW - Signal transduction KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19283680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Mechanoactive+Tenogenic+Differentiation+of+Human+Mesenchymal+Stem+Cells&rft.au=Kuo%2C+C+K%3BTuan%2C+R+S&rft.aulast=Kuo&rft.aufirst=C&rft.date=2008-10-01&rft.volume=14&rft.issue=10&rft.spage=1615&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2006.0415 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Wnt protein; Collagen; Tendons; Stem cells; Gene expression; Mesenchyme; Differentiation; Tissue engineering; Ligaments; Mechanical loading; Bone marrow; Matrix metalloproteinase; Fibroblasts; Signal transduction; Transcription; Extracellular matrix; Cartilage; Mechanical stimuli DO - http://dx.doi.org/10.1089/ten.tea.2006.0415 ER - TY - JOUR T1 - Association Properties of *bB1- and *bA3-Crystallins: Ability To Form Heterotetramers AN - 754545778; 13264214 AB - As major constituents of the mammalian lens, *b-crystallins associate into dimers, tetramers, and higher-order complexes to maintain lens transparency and refractivity. A previous study has shown that dimerization of *bB2- and *bA3-crystallins is energetically highly favored and entropically driven. While heterodimers further associate into higher-order complexes in vivo, a significant level of reversibly associated tetrameric crystallin has not been previously observed in vitro. To enhance our understanding of the interactions between *b-crystallins, we characterized the association of *bB1-crystallin, a major component of large *b-crystallin complexes (*b-high), with itself and with *bA3-crystallin. Mouse *bB1-crystallin and human *bA3-crystallin were expressed in Escherichia coli and purified chromatographically. Their association was then characterized using size-exclusion chromatography, native gel electrophoresis, isoelectric focusing, and analytical sedimentation equilibrium centrifugation. When present alone, each *b-crystallin associates into homodimers; however, no tetramer formation is seen. Once mixing has taken place, formation of a heterocomplex between *bB1- and *bA3-crystallins is observed using size-exclusion chromatography, native gel electrophoresis, isoelectric focusing, and sedimentation equilibrium. In contrast to results previously obtained after *bB2- and *bA3-crystallins had been mixed, mixed *bB1- and *bA3-crystallins show a dimer-tetramer equilibrium with a Kd of 1.1 *mM, indicating that these two *b-crystallins associate predominantly into heterotetramers in vitro. Thus, while each purified *b-crystallin associates only into homodimers and under the conditions studied mixed *bB2- and *bA3-crystallins form a mixture of homo- and heterodimers, mixed *bB1- and *bA3-crystallins associate predominantly into heterotetramers in equilibrium with heterodimers. These findings suggest a unique role for *bB1-crystallin in promoting higher-order crystallin association in the lens. JF - Biochemistry (Washington) AU - Chan, May P AU - Dolinska, Monika AU - Sergeev, Yuri V AU - Wingfield, Paul T AU - Hejtmancik, J Fielding AD - National Eye Institute and National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/09/30/ PY - 2008 DA - 2008 Sep 30 SP - 11062 EP - 11069 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA VL - 47 IS - 42 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Crystallin KW - Centrifugation KW - Chromatography KW - Refractivity KW - Escherichia coli KW - Isoelectric focusing KW - Sedimentation KW - Gel electrophoresis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754545778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Association+Properties+of+*bB1-+and+*bA3-Crystallins%3A+Ability+To+Form+Heterotetramers&rft.au=Chan%2C+May+P%3BDolinska%2C+Monika%3BSergeev%2C+Yuri+V%3BWingfield%2C+Paul+T%3BHejtmancik%2C+J+Fielding&rft.aulast=Chan&rft.aufirst=May&rft.date=2008-09-30&rft.volume=47&rft.issue=42&rft.spage=11062&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi8012438 L2 - http://pubs.acs.org/doi/abs/10.1021/bi8012438 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Centrifugation; Crystallin; Chromatography; Refractivity; Isoelectric focusing; Sedimentation; Gel electrophoresis; Escherichia coli DO - http://dx.doi.org/10.1021/bi8012438 ER - TY - JOUR T1 - Detection of low avidity CD8 super(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers AN - 21039309; 8578435 AB - The development of soluble recombinant peptide-major histocompatibility complex class I (pMHCI) molecules conjugated in multimeric form to fluorescent labels has enabled the physical quantification and characterization of antigen-specific CD8 super(+) T cell populations by flow cytometry. Several factors determine the binding threshold that enables visualization of cognate CD8 super(+) T cells with these reagents; these include the affinity of the T cell receptor (TCR) for pMHCI antigen. Here, we show that multimers constructed from peptide-human leukocyte antigen (pHLA) A approximately equal to 0201 monomers engineered in the heavy chain alpha 2 domain to enhance CD8 binding (K sub(D)~85 mu M) without impacting the TCR binding platform can detect cognate CD8 super(+) T cells bearing low affinity TCRs that are not visible with the corresponding wildtype pHLA A approximately equal to 0201 multimeric complexes. Mechanistically, this effect is mediated by a disproportionate enhancement of the TCR/pMHCI association rate. In direct ex vivo applications, these coreceptor-enhanced multimers exhibit faithful cognate binding properties; concomitant increases in background staining within the non-cognate CD8 super(+) T cell population can be resolved phenotypically using polychromatic flow cytometry as a mixture of naive and memory cells. These findings provide the first validation of a novel approach to the physical detection of low avidity antigen-specific CD8 super(+) T cell populations; such coreceptor-enhanced multimeric reagents are likely to be useful in a multitude of settings for the detection of auto-immune, tumor-specific and cross-reactive CD8 super(+) T cells. JF - Journal of Immunological Methods AU - Melenhorst, J J AU - Scheinberg, P AU - Chattopadhyay, P K AU - Lissina, A AU - Gostick, E AU - Cole, D K AU - Wooldridge, L AU - van den Berg, HA AU - Bornstein, E AU - Hensel, N F AU - Douek, D C AU - Roederer, M AU - Sewell, A K AU - Barrett, A J AU - Price, DA AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, priced6@cardiff.ac.uk Y1 - 2008/09/30/ PY - 2008 DA - 2008 Sep 30 SP - 31 EP - 39 PB - Elsevier Science, P.O. Box 211 Langford Lane Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 338 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Flow cytometry KW - Monomers KW - Avidity KW - double prime T-cell receptor KW - Leukocytes KW - Lymphocytes T KW - Memory cells KW - Major histocompatibility complex KW - CD8 antigen KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21039309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Detection+of+low+avidity+CD8+super%28%2B%29+T+cell+populations+with+coreceptor-enhanced+peptide-major+histocompatibility+complex+class+I+tetramers&rft.au=Melenhorst%2C+J+J%3BScheinberg%2C+P%3BChattopadhyay%2C+P+K%3BLissina%2C+A%3BGostick%2C+E%3BCole%2C+D+K%3BWooldridge%2C+L%3Bvan+den+Berg%2C+HA%3BBornstein%2C+E%3BHensel%2C+N+F%3BDouek%2C+D+C%3BRoederer%2C+M%3BSewell%2C+A+K%3BBarrett%2C+A+J%3BPrice%2C+DA&rft.aulast=Melenhorst&rft.aufirst=J&rft.date=2008-09-30&rft.volume=338&rft.issue=1-2&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2008.07.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Monomers; Flow cytometry; Avidity; double prime T-cell receptor; Leukocytes; Memory cells; Lymphocytes T; Major histocompatibility complex; CD8 antigen DO - http://dx.doi.org/10.1016/j.jim.2008.07.008 ER - TY - JOUR T1 - The mammary microenvironment alters the differentiation repertoire of neural stem cells AN - 20213701; 10316088 AB - A fundamental issue in stem cell biology is whether adult somatic stem cells are capable of accessing alternate tissue sites and continue functioning as stem cells in the new microenvironment. To address this issue relative to neurogenic stem cells in the mouse mammary gland microenvironment, we mixed wild-type mammary epithelial cells (MECs) with bona fide neural stem cells (NSCs) isolated from WAP-Cre/Rosa26R mice and inoculated them into cleared fat pads of immunocompromised females. Hosts were bred 6-8 weeks later and examined postinvolution. This allowed for mammary tissue growth, transient activation of the WAP-Cre gene, recombination, and constitutive expression of LacZ. The NSCs and their progeny contributed to mammary epithelial growth during ductal morphogenesis, and the Rosa26-LacZ reporter gene was activated by WAP-Cre expression during pregnancy. Some NSC-derived LacZ super(+) cells expressed mammary-specific functions, including milk protein synthesis, whereas others adopted myoepithelial cell fates. Thus, NSCs and their progeny enter mammary epithelium-specific niches and adopt the function of similarly endowed mammary cells. This result supports the conclusion that tissue-specific signals emanating from the stroma and from the differentiated somatic cells of the mouse mammary gland can redirect the NSCs to produce cellular progeny committed to MEC fates. JF - Proceedings of the National Academy of Sciences, USA AU - Booth, Brian W AU - Mack, David L AU - Andoutsellis-Theotokis, Andreas AU - McKay, Ronald DG AU - Boulanger, Corinne A AU - Smith, Gilbert H Y1 - 2008/09/30/ PY - 2008 DA - 2008 Sep 30 SP - 14891 EP - 14896 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 39 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - transplantation KW - niche KW - plasticity KW - trans-differentiation KW - regeneration KW - Stroma KW - Epithelial cells KW - Milk KW - Protein biosynthesis KW - Mammary gland KW - Morphogenesis KW - Somatic cells KW - Pregnancy KW - Differentiation KW - Recombination KW - Stem cells KW - Reporter gene KW - Microenvironments KW - Progeny KW - Cell fate KW - Neural stem cells KW - W 30910:Imaging KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20213701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=The+mammary+microenvironment+alters+the+differentiation+repertoire+of+neural+stem+cells&rft.au=Booth%2C+Brian+W%3BMack%2C+David+L%3BAndoutsellis-Theotokis%2C+Andreas%3BMcKay%2C+Ronald+DG%3BBoulanger%2C+Corinne+A%3BSmith%2C+Gilbert+H&rft.aulast=Booth&rft.aufirst=Brian&rft.date=2008-09-30&rft.volume=105&rft.issue=39&rft.spage=14891&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0803214105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stroma; Epithelial cells; Protein biosynthesis; Milk; Mammary gland; Morphogenesis; Somatic cells; Pregnancy; Recombination; Differentiation; Stem cells; Reporter gene; Microenvironments; Progeny; Cell fate; Neural stem cells DO - http://dx.doi.org/10.1073/pnas.0803214105 ER - TY - JOUR T1 - Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. AN - 69574095; 18635547 AB - Aberrant phosphorylation of neuronal cytoskeletal proteins is a key pathological event in neurodegenerative disorders such as Alzheimer disease (AD) and amyotrophic lateral sclerosis, but the underlying mechanisms are still unclear. Previous studies have shown that Pin1, a peptidylprolyl cis/trans-isomerase, may be actively involved in the regulation of Tau hyperphosphorylation in AD. Here, we show that Pin1 modulates oxidative stress-induced NF-H phosphorylation. In an in vitro kinase assay, the addition of Pin1 substantially increased phosphorylation of NF-H KSP repeats by proline-directed kinases, Erk1/2, Cdk5/p35, and JNK3 in a concentration-dependent manner. In vivo, dominant-negative (DN) Pin1 and Pin1 small interfering RNA inhibited epidermal growth factor-induced NF-H phosphorylation. Because oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, we studied the role of Pin1 in stressed cortical neurons and HEK293 cells. Both hydrogen peroxide (H(2)O(2)) and heat stresses induce phosphorylation of NF-H in transfected HEK293 cells and primary cortical cultures. Knockdown of Pin1 by transfected Pin1 short interference RNA and DN-Pin1 rescues the effect of stress-induced NF-H phosphorylation. The H(2)O(2) and heat shock induced perikaryal phospho-NF-H accumulations, and neuronal apoptosis was rescued by inhibition of Pin1 in cortical neurons. JNK3, a brain-specific JNK isoform, is activated under oxidative and heat stresses, and inhibition of Pin1 by Pin1 short interference RNA and DN-Pin1 inhibits this pathway. These results implicate Pin1 as a possible modulator of stress-induced NF-H phosphorylation as seen in neurodegenerative disorders like AD and amyotrophic lateral sclerosis. Thus, Pin1 may be a potential therapeutic target for these diseases. JF - The Journal of biological chemistry AU - Rudrabhatla, Parvathi AU - Zheng, Ya-Li AU - Amin, Niranjana D AU - Kesavapany, Sashi AU - Albers, Wayne AU - Pant, Harish C AD - Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/09/26/ PY - 2008 DA - 2008 Sep 26 SP - 26737 EP - 26747 VL - 283 IS - 39 SN - 0021-9258, 0021-9258 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - NIMA-Interacting Peptidylprolyl Isomerase KW - Neurofilament Proteins KW - Oxidants KW - PAPIN protein, rat KW - tau Proteins KW - neurofilament protein H KW - 108688-71-7 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Protein Kinases KW - EC 2.7.- KW - PIN1 protein, human KW - EC 5.2.1.8 KW - Peptidylprolyl Isomerase KW - Index Medicus KW - Animals KW - tau Proteins -- metabolism KW - Alzheimer Disease -- genetics KW - Amyotrophic Lateral Sclerosis -- genetics KW - Amyotrophic Lateral Sclerosis -- metabolism KW - Oxidants -- pharmacology KW - Humans KW - Hydrogen Peroxide -- pharmacology KW - Phosphorylation -- drug effects KW - Rats KW - Protein Kinases -- metabolism KW - Apoptosis -- genetics KW - Alzheimer Disease -- therapy KW - Amyotrophic Lateral Sclerosis -- therapy KW - Apoptosis -- drug effects KW - tau Proteins -- genetics KW - Rats, Wistar KW - Protein Kinases -- genetics KW - Alzheimer Disease -- metabolism KW - Cell Line KW - Peptidylprolyl Isomerase -- antagonists & inhibitors KW - Neurons -- metabolism KW - Cerebral Cortex -- metabolism KW - Peptidylprolyl Isomerase -- genetics KW - Neurofilament Proteins -- metabolism KW - Oxidative Stress -- genetics KW - Adaptor Proteins, Signal Transducing -- antagonists & inhibitors KW - Neurofilament Proteins -- antagonists & inhibitors KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Cerebral Cortex -- embryology KW - Neurofilament Proteins -- genetics KW - Oxidative Stress -- drug effects KW - Adaptor Proteins, Signal Transducing -- genetics KW - Heat-Shock Response -- drug effects KW - Peptidylprolyl Isomerase -- metabolism KW - Heat-Shock Response -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69574095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Pin1-dependent+prolyl+isomerization+modulates+the+stress-induced+phosphorylation+of+high+molecular+weight+neurofilament+protein.&rft.au=Rudrabhatla%2C+Parvathi%3BZheng%2C+Ya-Li%3BAmin%2C+Niranjana+D%3BKesavapany%2C+Sashi%3BAlbers%2C+Wayne%3BPant%2C+Harish+C&rft.aulast=Rudrabhatla&rft.aufirst=Parvathi&rft.date=2008-09-26&rft.volume=283&rft.issue=39&rft.spage=26737&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M801633200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-10 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci Res. 2000 Oct 1;62(1):75-83 [11002289] Proteins. 1993 Dec;17(4):355-62 [8108378] Nucleic Acids Res. 2001 Feb 1;29(3):767-73 [11160900] EMBO J. 2001 Jul 2;20(13):3459-72 [11432833] Nat Rev Neurosci. 2001 Nov;2(11):806-19 [11715057] Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1335-40 [11805292] J Biol Chem. 2002 Jun 21;277(25):23054-64 [11940573] Neurochem Res. 2003 Jul;28(7):1041-7 [12737529] J Biol Chem. 2003 Jul 11;278(28):26183-93 [12721297] Genes Dev. 2003 Nov 15;17(22):2765-76 [14600023] Nat Cell Biol. 2004 Apr;6(4):308-18 [15048125] J Neurosci. 2004 May 5;24(18):4421-31 [15128856] J Neurosci Res. 2004 Jun 15;76(6):795-800 [15160391] Free Radic Biol Med. 2004 Jul 15;37(2):139-45 [15203185] Nature. 1970 Aug 15;227(5259):680-5 [5432063] J Cell Biol. 1975 Aug;66(2):351-66 [49355] J Biol Chem. 1982 Sep 10;257(17):10467-70 [7202005] J Cell Biol. 1994 Aug;126(4):1031-46 [7519617] J Neurochem. 1994 Dec;63(6):2324-35 [7964754] Hum Mol Genet. 1994 Oct;3(10):1757-61 [7849698] J Neurochem. 1995 Jun;64(6):2681-90 [7760048] Trends Biochem Sci. 1995 Sep;20(9):374 [7482707] Biochem Cell Biol. 1995 Sep-Oct;73(9-10):575-92 [8714676] Biochem Cell Biol. 1995 Sep-Oct;73(9-10):593-7 [8714677] Brain Res Mol Brain Res. 1996 Jan;35(1-2):47-57 [8717339] J Biol Chem. 1996 Nov 29;271(48):30404-9 [8940004] Neuroscience. 1997 Nov;81(1):199-212 [9300412] Brain Res. 1997 Aug 15;765(2):259-66 [9313898] Nature. 1997 Oct 23;389(6653):865-70 [9349820] EMBO J. 1998 Aug 10;17(5):1315-27 [9482729] Electrophoresis. 1997 Dec;18(15):2714-23 [9504803] Biochemistry. 1998 Apr 28;37(17):5953-60 [9558330] J Neurosci. 1998 Jun 1;18(11):4008-21 [9592082] Biochemistry. 1998 Nov 17;37(46):16211-24 [9819213] J Biol Chem. 1999 Apr 9;274(15):10195-202 [10187804] Nature. 1999 Jun 24;399(6738):784-8 [10391244] J Biol Chem. 2005 Oct 21;280(42):35081-4 [16123044] Mol Cell Biol. 2005 Nov;25(21):9687-99 [16227615] Toxicol Appl Pharmacol. 2005 Nov 15;209(1):1-9 [16271620] J Biol Chem. 2006 Feb 17;281(7):4117-25 [16365047] Neuron. 2006 Mar 2;49(5):655-62 [16504941] Mol Cell. 2006 Jul 7;23(1):37-48 [16818231] EMBO J. 2007 Apr 4;26(7):1761-71 [17347650] Cell Death Differ. 2007 May;14(5):1001-10 [17218956] Mol Biol Cell. 2007 Sep;18(9):3645-55 [17626162] Nat Rev Mol Cell Biol. 2007 Nov;8(11):904-16 [17878917] J Cell Sci. 2000 Feb;113 ( Pt 3):401-7 [10639328] Proc Natl Acad Sci U S A. 1983 Oct;80(19):6126-30 [6577472] J Neurosci. 1987 Nov;7(11):3474-88 [3119789] Proc Natl Acad Sci U S A. 1988 Mar;85(6):1998-2002 [2450354] J Neuropathol Exp Neurol. 1988 Nov;47(6):642-53 [2459315] J Histochem Cytochem. 1989 Feb;37(2):241-7 [2492046] Brain Res Dev Brain Res. 1989 Nov 1;50(1):142-6 [2510955] Trends Neurosci. 1991 Nov;14(11):501-6 [1726767] Ann N Y Acad Sci. 2000;920:1-8 [11193136] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M801633200 ER - TY - JOUR T1 - Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells AN - 19688738; 8713128 AB - Protein Gene Product 9.5 (PGP9.5) is highly expressed in nervous tissue. Recently PGP9.5 expression has been found to be upregulated in the pulmonary epithelium of smokers and in non-small cell lung cancer, suggesting that it also plays a role in carcinogen-inflicted lung epithelial injury and carcinogenesis. We investigated the expression of PGP9.5 in mice in response to two prominent carcinogens found in tobacco smoke: Naphthalene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). By immunostaining, we found that PGP9.5 protein was highly expressed throughout the airway epithelium in the days immediately following a single injection of naphthalene. In contrast, PGP9.5 was exclusively confined to neurons and neuroendocrine cells in the control and NNK-exposed lungs. Furthermore, we investigated the expression of PGP9.5 mRNA in the lungs by quantitative RT-PCR (qPCR). PGP9.5 mRNA expression was highly upregulated in the days immediately following naphthalene injection and gradually returning to that of control mice 5 days after naphthalene injection. In contrast, exposure to NNK did not result in a significant increase in PGP9.5 mRNA 10 weeks after exposure. No increased expression of two other neuroendocrine markers was found in the non-neuroendocrine epithelial cells after naphthalene exposure. In contrast, immunostaining for the cell cycle regulator p27 super(K) super(i) super(p) super(1), which has previously been associated with PGP9.5 in lung cancer cells, revealed transient downregulation of p27 super(K) super(i) super(p) super(1) in naphthalene exposed airways compared to controls, indicating that the rise in PGP9.5 in the airway epithelium is related to downregulation of p27 super(K) super(i) super(p) super(1). This study is the first to specifically identify the carcinogen naphthalene as an inducer of PGP9.5 expression in non-neuroendocrine epithelium after acute lung injury and further strengthens the accumulating evidence of PGP9.5 as a central player in lung epithelial damage and early carcinogenesis. JF - Toxicology Letters AU - Poulsen, T T AU - Naizhen, X AU - Poulsen, H S AU - Linnoila, R I AD - CCBB, CCR, NCI, NIH 37 Convent Drive, Room 1056B, Bethesda, MD 20892, USA, il17h@nih.gov Y1 - 2008/09/26/ PY - 2008 DA - 2008 Sep 26 SP - 67 EP - 74 PB - Elsevier Science, Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 181 IS - 2 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Epithelial cells KW - Injuries KW - Cell cycle KW - Non-small cell lung carcinoma KW - Naphthalene KW - Carcinogens KW - Smoke KW - Gene expression KW - Cyclin-dependent kinase inhibitor p27 KW - Neurons KW - Carcinogenesis KW - Tobacco KW - Polymerase chain reaction KW - 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone KW - Epithelium KW - protein gene product 9.5 KW - Lung cancer KW - Respiratory tract KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19688738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Acute+damage+by+naphthalene+triggers+expression+of+the+neuroendocrine+marker+PGP9.5+in+airway+epithelial+cells&rft.au=Poulsen%2C+T+T%3BNaizhen%2C+X%3BPoulsen%2C+H+S%3BLinnoila%2C+R+I&rft.aulast=Poulsen&rft.aufirst=T&rft.date=2008-09-26&rft.volume=181&rft.issue=2&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2008.06.872 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Injuries; Non-small cell lung carcinoma; Cell cycle; Naphthalene; Carcinogens; Gene expression; Smoke; Neurons; Cyclin-dependent kinase inhibitor p27; Carcinogenesis; Tobacco; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; Polymerase chain reaction; Epithelium; protein gene product 9.5; Respiratory tract; Lung cancer DO - http://dx.doi.org/10.1016/j.toxlet.2008.06.872 ER - TY - JOUR T1 - Cholinesterase research at the National Institutes of Health, USA. AN - 69519593; 18550039 AB - Presented below is a brief description of research supported by the National Institutes of Health (NIH) on cholinesterases that was discussed at the IXth International Meeting on Cholinesterases in Suzhou, China. It is a partial description of the research conducted by researchers at academic and other institutions supported by the NIH, and by some of the researchers in NIH intramural laboratories. It does not represent a comprehensive survey of all research supported by the NIH related to cholinesterases, but rather a brief discussion of some of the studies discussed at the IXth International Meeting on Cholinesterases. The article describes exciting basic, translational and clinical research on therapies for neurological and other diseases. In addition, cholinesterases that may treat substance abuse are discussed, and pesticide and chemical warfare agents that inhibit cholinesterases are highlighted as part of the NIH portfolio. It is the intent of this article to share with the international community some of the research being supported by the NIH on cholinesterases that complements many of the studies being conducted elsewhere. The information was obtained only from published articles or from abstracts available to the public within the NIH CRISP database (http://crisp.cit.nih.gov/). JF - Chemico-biological interactions AU - Jett, David A AD - Institute of Neurological Disorders and Stroke, National Institutes of Health, 6001 Executive Boulevard, Bethesda, MD 20892-9535, USA. jettd@ninds.nih.gov Y1 - 2008/09/25/ PY - 2008 DA - 2008 Sep 25 SP - 22 EP - 25 VL - 175 IS - 1-3 SN - 0009-2797, 0009-2797 KW - Chemical Warfare Agents KW - 0 KW - Cholinesterase Inhibitors KW - Cholinesterases KW - EC 3.1.1.8 KW - Index Medicus KW - United States KW - Cholinesterase Inhibitors -- pharmacology KW - Substance-Related Disorders -- enzymology KW - Humans KW - National Institutes of Health (U.S.) KW - Chemical Warfare Agents -- pharmacology KW - Cholinesterases -- metabolism KW - Cholinesterases -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69519593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Cholinesterase+research+at+the+National+Institutes+of+Health%2C+USA.&rft.au=Jett%2C+David+A&rft.aulast=Jett&rft.aufirst=David&rft.date=2008-09-25&rft.volume=175&rft.issue=1-3&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/10.1016%2Fj.cbi.2008.04.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-10 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cbi.2008.04.021 ER - TY - JOUR T1 - A mathematical approach for evaluating the influence of dose heterogeneity on TCP for prostate cancer brachytherapy treatment. AN - 69473755; 18723926 AB - The low-dose-rate brachytherapy technique has proven suitable for the management of prostate cancer. However, published data generally report the clinical outcome and the minimum peripheral dose (mPD) to the target volume and not the actual dose distribution in patients. To this end, modern guidelines recommend the use of specific dose and volume indices describing dose distribution throughout the target. The introduction of a method, based on the standard linear quadratic model and Poisson statistics, entitled the F-factor allows the TCP from different DVHs to be calculated, by using the TCP from a uniform dose distribution as the reference. The F-factor sensitivity against radiobiological parameters and influence of the DVH were evaluated. We applied the F-formula on the post-plan DVHs of 58 patients treated with (125)I permanent seed implant brachytherapy for localized prostate cancer. F shows a strong correlation with dosimetric parameters already reported as significant predictors of the biochemical outcome. JF - Physics in medicine and biology AU - Strigari, L AU - Orlandini, L C AU - Andriani, I AU - d'Angelo, A AU - Stefanacci, M AU - Di Nallo, A M AU - Benassi, Marcello AD - Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy. strigari@ifo.it Y1 - 2008/09/21/ PY - 2008 DA - 2008 Sep 21 SP - 5045 EP - 5059 VL - 53 IS - 18 SN - 0031-9155, 0031-9155 KW - Index Medicus KW - Relative Biological Effectiveness KW - Computer Simulation KW - Radiotherapy Dosage KW - Humans KW - Body Burden KW - Models, Statistical KW - Male KW - Radiotherapy, Computer-Assisted -- methods KW - Radiotherapy Planning, Computer-Assisted -- methods KW - Outcome Assessment (Health Care) -- methods KW - Brachytherapy -- methods KW - Radiometry -- mortality KW - Models, Biological KW - Prostatic Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69473755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+in+medicine+and+biology&rft.atitle=A+mathematical+approach+for+evaluating+the+influence+of+dose+heterogeneity+on+TCP+for+prostate+cancer+brachytherapy+treatment.&rft.au=Strigari%2C+L%3BOrlandini%2C+L+C%3BAndriani%2C+I%3Bd%27Angelo%2C+A%3BStefanacci%2C+M%3BDi+Nallo%2C+A+M%3BBenassi%2C+Marcello&rft.aulast=Strigari&rft.aufirst=L&rft.date=2008-09-21&rft.volume=53&rft.issue=18&rft.spage=5045&rft.isbn=&rft.btitle=&rft.title=Physics+in+medicine+and+biology&rft.issn=00319155&rft_id=info:doi/10.1088%2F0031-9155%2F53%2F18%2F013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1088/0031-9155/53/18/013 ER - TY - JOUR T1 - Solution NMR structure of selenium-binding protein from Methanococcus vannielii. AN - 69546190; 18650445 AB - Selenium is an important nutrient. The lack of selenium will suppress expression of various enzymes that will lead to cell abnormality and diseases. However, high concentrations of free selenium are toxic to the cell because it adversely affects numerous cell metabolic pathways. In Methanococcus vannielii, selenium transport in the cell is established by the selenium-binding protein, SeBP. SeBP sequesters selenium during transport, thus regulating the level of free selenium in the cell, and delivers it specifically to the selenophosphate synthase enzyme. In solution, SeBP is an oligomer of 8.8-kDa subunits. It is a symmetric pentamer. The solution structure of SeBP was determined by NMR spectroscopy. Each subunit of SeBP is composed of an alpha-helix on top of a 4-stranded twisted beta-sheet. The stability of the five subunits stems mainly from hydrophobic interactions and supplemented by hydrogen bond interactions. The loop containing Cys(59) has been shown to be important for selenium binding, is flexible, and adopts multiple conformations. However, the cysteine accessibility is restricted in the structure, reducing the possibility of the binding of free selenium readily. Therefore, a different selenium precursor or other factors might be needed to facilitate opening of this loop to expose Cys(59) for selenium binding. JF - The Journal of biological chemistry AU - Suzuki, Motoshi AU - Lee, Duck-Yeon AU - Inyamah, Nwakaego AU - Stadtman, Thressa C AU - Tjandra, Nico AD - Laboratory of Molecular Biophysics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/09/19/ PY - 2008 DA - 2008 Sep 19 SP - 25936 EP - 25943 VL - 283 IS - 38 SN - 0021-9258, 0021-9258 KW - Recombinant Proteins KW - 0 KW - Selenium-Binding Proteins KW - Selenium KW - H6241UJ22B KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Static Electricity KW - Protein Structure, Secondary KW - Cysteine -- chemistry KW - Molecular Sequence Data KW - Mass Spectrometry -- methods KW - Amino Acid Sequence KW - Recombinant Proteins -- chemistry KW - Molecular Conformation KW - Hydrogen Bonding KW - Surface Properties KW - Protein Conformation KW - Selenium -- chemistry KW - Magnetic Resonance Spectroscopy -- methods KW - Selenium-Binding Proteins -- chemistry KW - Methanococcus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69546190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Solution+NMR+structure+of+selenium-binding+protein+from+Methanococcus+vannielii.&rft.au=Suzuki%2C+Motoshi%3BLee%2C+Duck-Yeon%3BInyamah%2C+Nwakaego%3BStadtman%2C+Thressa+C%3BTjandra%2C+Nico&rft.aulast=Suzuki&rft.aufirst=Motoshi&rft.date=2008-09-19&rft.volume=283&rft.issue=38&rft.spage=25936&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M803773200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-27 N1 - Date created - 2008-09-15 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2JZ7; PDB N1 - SuppNotes - Cited By: Lancet. 2000 Jul 15;356(9225):233-41 [10963212] Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12029-34 [16103372] J Magn Reson. 2003 Jan;160(1):65-73 [12565051] Science. 1974 Mar 8;183(4128):915-22 [4605100] J Bacteriol. 1988 Feb;170(2):540-6 [2962989] Biofactors. 1988 Oct;1(3):245-50 [2978458] Biochemistry. 1989 Sep 19;28(19):7510-6 [2692701] Proc Natl Acad Sci U S A. 1990 Jan;87(2):543-7 [2405383] Science. 1990 Jul 27;249(4967):411-4 [2377896] Biochemistry. 1991 Jan 8;30(1):12-8 [1988012] Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2975-9 [1557403] Biochemistry. 1992 Jun 16;31(23):5269-78 [1606151] J Biomol NMR. 1992 Jan;2(1):33-56 [1422145] J Mol Biol. 1993 Sep 5;233(1):123-38 [8377180] FEBS Lett. 1994 Aug 15;350(1):87-90 [8062930] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] J Mol Graph. 1996 Feb;14(1):51-5, 29-32 [8744573] J Biomol NMR. 1996 Dec;8(4):477-86 [9008363] Nat Struct Biol. 1997 Sep;4(9):732-8 [9303001] J Magn Reson. 1998 Oct;134(2):365-9 [9761712] J Biomol NMR. 1999 Mar;13(3):289-302 [10212987] J Biomol NMR. 1999 Jun;14(2):181-4 [10427744] Carcinogenesis. 1999 Sep;20(9):1657-66 [10469608] IUBMB Life. 2004 Jul;56(7):427-31 [15545220] IUBMB Life. 2004 Aug;56(8):501-7 [15545230] Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1012-6 [15653770] Biochim Biophys Acta. 2005 May 25;1723(1-3):215-20 [15780970] Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9150-3 [12084818] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M803773200 ER - TY - JOUR T1 - Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer AN - 19716130; 8560488 AB - Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted. JF - Journal of the National Cancer Institute AU - Liu, Pengyuan AU - Vikis, Haris G AU - Wang, Daolong AU - Lu, Yan AU - Wang, Yian AU - Schwartz, Ann G AU - Pinney, Susan M AU - Yang, Ping AU - de Andrade, Mariza AU - Petersen, Gloria M AU - Wiest, Jonathan S AU - Fain, Pamela R AU - Gazdar, Adi AU - Gaba, Colette AU - Rothschild, Henry AU - Mandal, Diptasri AU - Coons, Teresa AU - Lee, Juwon AU - Kupert, Elena AU - Seminara, Daniela AU - Minna, John AU - Bailey-Wilson, Joan E AU - Wu, Xifeng AU - Spitz, Margaret R AU - Eisen, Timothy AU - Houlston, Richard S AU - Amos, Christopher I AU - Anderson, Marshall W AU - You, Ming AD - Affiliations of authors: Washington University, St Louis, MO (PL, HGV, DW, YL, YW, MY); Karmanos Cancer Institute, Detroit, MI (AGS); University of Cincinnati, Cincinnati, OH (SMP, JLM, WA); Mayo Clinic, Rochester, MN (PY, MdA, GMP, DS); National Cancer Institute, Bethesda, MD (JSW); University of Colorado, Denver, CO (PRF); University of Texas Southwestern Medical Center, Dallas, TX (AG, JM); University of Toledo College of Medicine, Toledo, OH (CG); Louisiana State University Health Science Center, New Orleans, LA (HR, DM); Saccomanno Research Institute, Grand Junction, CO (TC); National Human Genome Research Institute, Baltimore, MD (JEB-W); M. D. Anderson Cancer Center, Houston, TX (XW, MRS, CIA); Department of Oncology, University of Cambridge, Cambridge, CB2 2RE, UK (TE); Section of Cancer Genetics, Institute of Cancer Research, SM2 5NG, UK (RSH), youm@wudosis.wustl.edu Y1 - 2008/09/17/ PY - 2008 DA - 2008 Sep 17 SP - 1326 EP - 1330 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 18 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Genetics KW - DNA KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Familial+Aggregation+of+Common+Sequence+Variants+on+15q24-25.1+in+Lung+Cancer&rft.au=Liu%2C+Pengyuan%3BVikis%2C+Haris+G%3BWang%2C+Daolong%3BLu%2C+Yan%3BWang%2C+Yian%3BSchwartz%2C+Ann+G%3BPinney%2C+Susan+M%3BYang%2C+Ping%3Bde+Andrade%2C+Mariza%3BPetersen%2C+Gloria+M%3BWiest%2C+Jonathan+S%3BFain%2C+Pamela+R%3BGazdar%2C+Adi%3BGaba%2C+Colette%3BRothschild%2C+Henry%3BMandal%2C+Diptasri%3BCoons%2C+Teresa%3BLee%2C+Juwon%3BKupert%2C+Elena%3BSeminara%2C+Daniela%3BMinna%2C+John%3BBailey-Wilson%2C+Joan+E%3BWu%2C+Xifeng%3BSpitz%2C+Margaret+R%3BEisen%2C+Timothy%3BHoulston%2C+Richard+S%3BAmos%2C+Christopher+I%3BAnderson%2C+Marshall+W%3BYou%2C+Ming&rft.aulast=Liu&rft.aufirst=Pengyuan&rft.date=2008-09-17&rft.volume=100&rft.issue=18&rft.spage=1326&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn268 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Lung cancer; Genetics; DNA DO - http://dx.doi.org/10.1093/jnci/djn268 ER - TY - JOUR T1 - A powerful method combining homologous recombination and site-specific recombination for targeted mutagenesis in Drosophila. AN - 69559866; 18772376 AB - Gene targeting provides a powerful tool for dissecting gene function. However, repeated targeting of a single locus remains a practice mostly limited to unicellular organisms that afford simple targeting methodologies. We developed an efficient method to repeatedly target a single locus in Drosophila. In this method, which we term "site-specific integrase mediated repeated targeting" (SIRT), an attP attachment site for the phage phiC31 integrase is first targeted to the vicinity of the gene of interest by homologous recombination. All subsequent modifications of that gene are introduced by phiC31-mediated integration of plasmids carrying an attB attachment site and the desired mutation. This highly efficient integration results in a tandem duplication of the target locus, which is then reduced into a single copy carrying the mutation, likely by the efficient "single strand annealing" mechanism, induced with a DNA double-strand break (DSB). We used SIRT to generate a series of six mutations in the Drosophila nbs gene, ranging from single amino acid replacements and small in-frame deletions to complete deletion of the gene. Because all of the components of SIRT are functional in many different organisms, it is readily adaptable to other multicellular organisms. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Gao, Guanjun AU - McMahon, Conor AU - Chen, Jie AU - Rong, Yikang S AD - Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/09/16/ PY - 2008 DA - 2008 Sep 16 SP - 13999 EP - 14004 VL - 105 IS - 37 KW - Index Medicus KW - Animals KW - Alleles KW - Male KW - Female KW - Gene Deletion KW - Drosophila melanogaster -- genetics KW - Recombination, Genetic -- genetics KW - Mutagenesis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69559866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=A+powerful+method+combining+homologous+recombination+and+site-specific+recombination+for+targeted+mutagenesis+in+Drosophila.&rft.au=Gao%2C+Guanjun%3BMcMahon%2C+Conor%3BChen%2C+Jie%3BRong%2C+Yikang+S&rft.aulast=Gao&rft.aufirst=Guanjun&rft.date=2008-09-16&rft.volume=105&rft.issue=37&rft.spage=13999&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0805843105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-09 N1 - Date created - 2008-09-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 May 23;97(11):5995-6000 [10801973] Methods Mol Biol. 2008;435:165-73 [18370075] Genetics. 2002 Jun;161(2):711-20 [12072467] Genes Dev. 2002 Jun 15;16(12):1568-81 [12080094] J Mol Biol. 2004 Jan 16;335(3):667-78 [14687564] Genetics. 2003 Dec;165(4):1831-42 [14704169] Genetics. 2004 Apr;166(4):1775-82 [15126397] Nucleic Acids Res. 1997 Sep 1;25(17):3379-88 [9254693] Nucleic Acids Res. 1997 Sep 15;25(18):3665-71 [9278488] Genetics. 2004 Nov;168(3):1477-89 [15579700] Nat Methods. 2005 Aug;2(8):583-5 [16094382] Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12483-8 [16116081] Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15167-72 [16203987] Genetics. 2006 Jun;173(2):769-77 [16547094] Science. 2006 Dec 15;314(5806):1747-51 [17138868] Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3312-7 [17360644] Adv Exp Med Biol. 2007;601:61-7 [17712992] Nat Genet. 2008 Apr;40(4):476-83 [18311141] Science. 2000 Jun 16;288(5473):2013-8 [10856208] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0805843105 ER - TY - JOUR T1 - Double-blind, placebo-controlled, pilot trial of botulinum toxin A in restless legs syndrome. AN - 69551222; 18794499 JF - Neurology AU - Nahab, Fatta B AU - Peckham, Elizabeth L AU - Hallett, Mark AD - Human Motor Control Section, NINDS/NIH, 10 Center Drive, Bldg 10, Room 5N226, Bethesda, MD 20892-1428, USA. nahabf@ninds.nih.gov Y1 - 2008/09/16/ PY - 2008 DA - 2008 Sep 16 SP - 950 EP - 951 VL - 71 IS - 12 KW - Neuromuscular Agents KW - 0 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Abridged Index Medicus KW - Index Medicus KW - Leg KW - Treatment Failure KW - Double-Blind Method KW - Muscle Weakness -- chemically induced KW - Humans KW - Cross-Over Studies KW - Pilot Projects KW - Middle Aged KW - Injections KW - Male KW - Female KW - Botulinum Toxins, Type A -- administration & dosage KW - Neuromuscular Agents -- adverse effects KW - Botulinum Toxins, Type A -- adverse effects KW - Botulinum Toxins, Type A -- therapeutic use KW - Restless Legs Syndrome -- drug therapy KW - Neuromuscular Agents -- administration & dosage KW - Neuromuscular Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69551222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Double-blind%2C+placebo-controlled%2C+pilot+trial+of+botulinum+toxin+A+in+restless+legs+syndrome.&rft.au=Nahab%2C+Fatta+B%3BPeckham%2C+Elizabeth+L%3BHallett%2C+Mark&rft.aulast=Nahab&rft.aufirst=Fatta&rft.date=2008-09-16&rft.volume=71&rft.issue=12&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/10.1212%2F01.wnl.0000325994.93782.a1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-16 N1 - Date created - 2008-09-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Sleep Med. 2003 Mar;4(2):121-32 [14592342] Clin Neurophysiol. 2004 Sep;115(9):1975-88 [15294200] Med Hypotheses. 2007;69(3):497-501 [17363179] Neurology. 2006 Sep 26;67(6):1034-9 [16931507] J Clin Sleep Med. 2006 Jul 15;2(3):275-8 [17561538] Mov Disord. 1995 Sep;10(5):634-42 [8552117] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1212/01.wnl.0000325994.93782.a1 ER - TY - JOUR T1 - Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension. AN - 742778565; pmid-18661549 AB - Patients with Parkinson's disease (PD) often have manifestations of autonomic failure. About 40% have neurogenic orthostatic hypotension (NOH), and among PD+NOH patients virtually all have evidence of cardiac sympathetic denervation; however, whether PD+NOH entails extra-cardiac noradrenergic denervation has been less clear. Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects. Microdialysate DHPG concentrations were similarly low in PD+NOH and PAF compared to control subjects (163 +/- 25, 153 +/- 27, and 304 +/- 27 pg/mL, P < 0.01 each vs. control). The two groups also had similarly small plasma DHPG responses to tyramine (71 +/- 58 and 82 +/- 105 vs. 313 +/- 94 pg/mL; P < 0.01 each vs. control) and NE responses to yohimbine (223 +/- 37 and 61 +/- 15 vs. 672 +/- 130 pg/mL, P < 0.01 each vs. control), and virtually absent NE responses to isoproterenol (20 +/- 34 and 14 +/- 15 vs. 336 +/- 78 pg/mL, P < 0.01 each vs. control). Patients with PD+NOH had normal bradycardia responses to edrophonium and normal epinephrine responses to glucagon. The results support the concept of generalized noradrenergic denervation in PD+NOH, with similar severity to that seen in PAF. In contrast, the parasympathetic cholinergic and adrenomedullary hormonal components of the autonomic nervous system seem intact in PD+NOH. (c) 2007 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Sharabi, Yehonatan AU - Imrich, Richard AU - Holmes, Courtney AU - Pechnik, Sandra AU - Goldstein, David S AD - Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/09/15/ PY - 2008 DA - 2008 Sep 15 SP - 1725 EP - 1732 VL - 23 IS - 12 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Methoxyhydroxyphenylglycol -- metabolism KW - Bradycardia -- drug therapy KW - Glucagon -- therapeutic use KW - Cholinesterase Inhibitors -- therapeutic use KW - Humans KW - Aged KW - Pure Autonomic Failure -- drug therapy KW - Methoxyhydroxyphenylglycol -- analogs & derivatives KW - Tyramine -- administration & dosage KW - Microdialysis -- methods KW - Isoproterenol -- diagnostic use KW - Yohimbine -- diagnostic use KW - Edrophonium -- therapeutic use KW - Yohimbine -- administration & dosage KW - Tyramine -- diagnostic use KW - Middle Aged KW - Blood Pressure -- drug effects KW - Isoproterenol -- administration & dosage KW - Epinephrine -- therapeutic use KW - Muscle, Skeletal -- metabolism KW - Male KW - Female KW - Hypotension, Orthostatic -- complications KW - Norepinephrine -- metabolism KW - Parkinson Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742778565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Generalized+and+neurotransmitter-selective+noradrenergic+denervation+in+Parkinson%27s+disease+with+orthostatic+hypotension.&rft.au=Sharabi%2C+Yehonatan%3BImrich%2C+Richard%3BHolmes%2C+Courtney%3BPechnik%2C+Sandra%3BGoldstein%2C+David+S&rft.aulast=Sharabi&rft.aufirst=Yehonatan&rft.date=2008-09-15&rft.volume=23&rft.issue=12&rft.spage=1725&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - SuppNotes - Cites: J Physiol. 2006 May 1;572(Pt 3):821-7[16513672]; Cites: J Nucl Med. 2006 Nov;47(11):1769-77[17079809]; Cites: Clin Auton Res. 2006 Feb;16(1):46-54[16477495]; Cites: J Nucl Med. 2005 Nov;46(11):1775-81[16269589]; Cites: Hypertension. 2005 Aug;46(2):355-9[15967868]; Cites: Ann Nucl Med. 2005 May;19(3):225-9[15981676]; Cites: Hypertension. 2005 Jul;46(1):1-6[15911739]; Cites: Clin Auton Res. 2000 Oct;10(5):285-91[11198484]; Cites: Ann Intern Med. 2000 Sep 5;133(5):338-47[10979878]; Cites: Eur J Nucl Med. 2000 May;27(5):566-73[10853813]; Cites: Horm Metab Res. 2005 Apr;37(4):205-8[15952078]; Cites: Brain Pathol. 2005 Jan;15(1):29-34[15779234]; Cites: Eur Neurol. 1997;38 Suppl 2:2-7[9387796]; Cites: Acta Neuropathol. 1997 Aug;94(2):192-6[9255396]; Cites: N Engl J Med. 1997 Mar 6;336(10):696-702[9041100]; Cites: J Auton Nerv Syst. 1995 Jun 25;53(2-3):230-4[7560760]; Cites: Am J Physiol. 1995 Jan;268(1 Pt 2):R278-85[7840332]; Cites: Fundam Clin Pharmacol. 1991;5(6):539-48[1659556]; Cites: Am J Physiol. 1991 Jan;260(1 Pt 2):R142-7[1847020]; Cites: Eur J Clin Invest. 1990 Dec;20(6):613-9[1964123]; Cites: Ann Neurol. 1989 Oct;26(4):558-63[2510587]; Cites: Clin Pharmacol Ther. 1986 Aug;40(2):233-8[3731686]; Cites: Naunyn Schmiedebergs Arch Pharmacol. 1983 Dec;324(4):256-63[6141531]; Cites: Klin Wochenschr. 1982 May 3;60(9):465-70[7045511]; Cites: Neurology. 1981 Jan;31(1):1-7[7192816]; Cites: Circulation. 1982 Aug;66(2):432-9[7094250]; Cites: J Neurol Neurosurg Psychiatry. 1976 Nov;39(11):1092-100[188990]; Cites: Chest. 1975 Feb;67(2):147-51[1116389]; Cites: Semin Neurol. 2003 Dec;23(4):351-63[15088256]; Cites: J Cardiovasc Pharmacol. 2003 Jan;41(1):126-31[12500030]; Cites: Circulation. 2003 May 20;107(19):2475-9[12707242]; Cites: Neurology. 2003 Apr 22;60(8):1327-32[12707437]; Cites: Neurology. 2003 Mar 25;60(6):1036-9[12654979]; Cites: J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):776-7[12438492]; Cites: Clin Auton Res. 2002 Feb;12(1):13-9[12102443]; Cites: Neurology. 2002 Apr 23;58(8):1247-55[11971094]; Cites: Neurology. 2001 Sep 25;57(6):1140-1[11571358]; Cites: J Physiol. 2000 Nov 1;528(Pt 3):407-17[11060120]; Cites: J Hypertens. 2007 Nov;25(11):2286-95[17921824]; Cites: Acta Neuropathol. 2007 Jan;113(1):81-6[17089131]; Cites: Clin Neuropharmacol. 2006 May-Jun;29(3):97-105[16772807] N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Folliculotropic mycosis fungoides and a leonine clinical appearance of the face. AN - 69870554; 19061588 AB - A 73-year-old man presented with a two year history of multiple nodules and follicular papules accompanied by slight itching on the face and the forearm. A physical examination showed multiple, soft, erythematous nodules on the forehead, cheek, and jaw, contributing to a generally leonine appearance of the face. Histopathological examination from the forehead revealed dense, massive concentrations of atypical lymphocytes in the dermis, and the forearm showed infiltration of atypical lymphocytes predominantly around the follicles. We diagnosed this condition as folliculotropic cutaneous T cell lymphoma (CTCL). EPOCH therapy was very effective and the lesions of the forehead and forearm showed a decrease in tumor elevation; the histology showed a precipitous decrease in the number of the atypical lymphocytes. JF - Dermatology online journal AU - Ito, Tomonobu AU - Yamamoto, Toshiyuki AU - Matsumoto, Yuka AU - Wakamatsu, Junko AU - Kato, Yukihiko AU - Tsuboi, Ryoji AD - Department of Dermatology, Tokyo Medical University, Tokyo, Japan. itoto@niaid.nih.gov Y1 - 2008/09/15/ PY - 2008 DA - 2008 Sep 15 SP - 6 VL - 14 IS - 9 KW - Interferon-alpha KW - 0 KW - Vincristine KW - 5J49Q6B70F KW - Etoposide KW - 6PLQ3CP4P3 KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisolone KW - 9PHQ9Y1OLM KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Doxorubicin -- analogs & derivatives KW - Interferon-alpha -- therapeutic use KW - Humans KW - Vincristine -- administration & dosage KW - Aged KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Doxorubicin -- administration & dosage KW - PUVA Therapy KW - Etoposide -- administration & dosage KW - Prednisolone -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Arm -- pathology KW - Prednisone -- administration & dosage KW - Male KW - Skin Neoplasms -- drug therapy KW - Facial Neoplasms -- diagnosis KW - Hair Follicle -- pathology KW - Facial Neoplasms -- drug therapy KW - Facial Neoplasms -- complications KW - Skin Neoplasms -- diagnosis KW - Skin Neoplasms -- pathology KW - Skin Neoplasms -- complications KW - Mycosis Fungoides -- complications KW - Facial Neoplasms -- pathology KW - Mycosis Fungoides -- diagnosis KW - Mycosis Fungoides -- drug therapy KW - Mycosis Fungoides -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69870554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dermatology+online+journal&rft.atitle=Folliculotropic+mycosis+fungoides+and+a+leonine+clinical+appearance+of+the+face.&rft.au=Ito%2C+Tomonobu%3BYamamoto%2C+Toshiyuki%3BMatsumoto%2C+Yuka%3BWakamatsu%2C+Junko%3BKato%2C+Yukihiko%3BTsuboi%2C+Ryoji&rft.aulast=Ito&rft.aufirst=Tomonobu&rft.date=2008-09-15&rft.volume=14&rft.issue=9&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Dermatology+online+journal&rft.issn=1087-2108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-19 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Soluble CD22 as a tumor marker for hairy cell leukemia. AN - 69525935; 18596230 AB - CD22 is an important immunotherapeutic target on B-cell malignancies, particularly hairy cell leukemia (HCL), but its soluble extracellular domain, sCD22, has not yet been reported in the blood. By immunoaffinity and enzyme-linked immunosorbent assay techniques using anti-CD22 monoclonal antibodies, we identified the 100-kDa extracellular domain of CD22 and an 80-kDa processed form in serum of patients with HCL. The median sCD22 level measured by enzyme-linked immunosorbent assay was 18 ng/mL for 93 patients with HCL. sCD22 levels varied from 2.1 to 163 ng/mL and were higher (P < .001) than 23 normal donors (median, 0.6 ng/mL). More than 95% of normal donors had sCD22 levels less than 1.9 ng/mL. sCD22 levels were proportional to concentrations of circulating HCL cells (P = .002), and HCL spleen size (P < .001). sCD22 levels normalized with complete but not partial response to treatment. sCD22 levels up to 300 ng/mL had less than a 2-fold effect on the cytotoxicity of the anti-CD22 recombinant immunotoxin BL22. sCD22 levels may be useful to follow in patients with HCL and may be more specific than sCD25 in patients with CD22(+)/CD25(-) disease. Trials are listed on www.cancer.gov as NCT00002765, NCT00021983, NCT00074048, NCT00085085, NCT00337311, and NCT00462189. JF - Blood AU - Matsushita, Kakushi AU - Margulies, Inger AU - Onda, Masanori AU - Nagata, Satoshi AU - Stetler-Stevenson, Maryalice AU - Kreitman, Robert J AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20854-4255, USA. Y1 - 2008/09/15/ PY - 2008 DA - 2008 Sep 15 SP - 2272 EP - 2277 VL - 112 IS - 6 KW - Biomarkers, Tumor KW - 0 KW - Immunotoxins KW - Sialic Acid Binding Ig-like Lectin 2 KW - Abridged Index Medicus KW - Index Medicus KW - Solubility KW - Immunotoxins -- toxicity KW - Humans KW - Diagnostic Techniques and Procedures KW - Case-Control Studies KW - Tumor Burden KW - Enzyme-Linked Immunosorbent Assay KW - Biomarkers, Tumor -- blood KW - Molecular Weight KW - Leukemia, Hairy Cell -- drug therapy KW - Sialic Acid Binding Ig-like Lectin 2 -- blood KW - Leukemia, Hairy Cell -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69525935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Soluble+CD22+as+a+tumor+marker+for+hairy+cell+leukemia.&rft.au=Matsushita%2C+Kakushi%3BMargulies%2C+Inger%3BOnda%2C+Masanori%3BNagata%2C+Satoshi%3BStetler-Stevenson%2C+Maryalice%3BKreitman%2C+Robert+J&rft.aulast=Matsushita&rft.aufirst=Kakushi&rft.date=2008-09-15&rft.volume=112&rft.issue=6&rft.spage=2272&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-01-131987 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-30 N1 - Date created - 2008-09-09 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00021983; ClinicalTrials.gov; NCT00462189; NCT00074048; NCT00337311; NCT00085085; NCT00002765 N1 - SuppNotes - Cited By: Ann Oncol. 2002 Dec;13(12):1908-14 [12453859] Haematologica. 2002 Jul;87(7):701-8; discussion 708 [12091120] Cytometry B Clin Cytom. 2003 Mar;52(1):1-12 [12599176] Blood. 2003 Apr 1;101(7):2507-13 [12446458] Tumour Biol. 2003 Jan-Feb;24(1):53-60 [12743427] Br J Haematol. 2003 Dec;123(5):850-7 [14632776] Cancer. 2004 Sep 1;101(5):999-1008 [15329909] Leuk Lymphoma. 2004 Oct;45(10):2111-8 [15370258] Cell Immunol. 1989 Jan;118(1):85-99 [2463099] Ann Clin Lab Sci. 1990 May-Jun;20(3):163-8 [2188562] Ann Intern Med. 1990 Oct 15;113(8):619-27 [2205142] Cancer. 1991 May 1;67(9):2295-9 [2013037] Cancer Res. 1991 Aug 1;51(15):4052-8 [1855219] Cancer Res. 1993 Jan 15;53(2):340-7 [8417828] Cancer Res. 1993 Feb 15;53(4):819-25 [8428363] J Immunol. 1993 Jun 1;150(11):4715-8 [8496586] Blood. 1993 Aug 15;82(4):1277-87 [7688993] Blood. 1993 Nov 1;82(9):2624-33 [8219217] Blood. 1995 Jun 15;85(12):3457-65 [7780133] Semin Immunol. 1998 Aug;10(4):287-97 [9695185] Clin Cancer Res. 2005 Feb 15;11(4):1545-50 [15746059] Leukemia. 2005 May;19(5):883-5 [15744355] Curr Opin Immunol. 2005 Jun;17(3):290-7 [15886119] Clin Cancer Res. 2005 May 15;11(10):3879-88 [15897589] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Immunol Invest. 2006;35(1):93-114 [16531332] Br J Haematol. 2006 Apr;133(2):165-72 [16611307] Cancer. 2006 May 15;106(10):2148-57 [16598754] Clin Cancer Res. 2006 May 1;12(9):2804-11 [16675574] Clin Chem Lab Med. 2006;44(5):594-602 [16681430] Eur J Haematol. 2006 Sep;77(3):217-25 [16856931] Mediators Inflamm. 2006;2006(3):42394 [16951490] Eur J Haematol. 2006 Nov;77(5):387-94 [16879607] Klin Padiatr. 2006 Nov-Dec;218(6):327-33 [17080335] Leukemia. 2006 Dec;20(12):2102-10 [17051247] Leukemia. 2007 Jan;21(1):169-74 [17051241] Oncogene. 2007 May 28;26(25):3704-13 [17530024] Thorax. 2007 Jul;62(7):569-76 [17356060] Biomarkers. 2008 Feb;13(1):1-26 [17906988] Neoplasma. 2006;53(1):26-9 [16416009] Blood. 2000 Jan 15;95(2):461-9 [10627450] Cancer J Sci Am. 2000 Jan-Feb;6(1):21-4 [10696734] Clin Cancer Res. 2000 Apr;6(4):1476-87 [10778980] Blood. 2001 Jan 15;97(2):528-35 [11154233] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Cancer. 2001 Aug 15;92(4):713-9 [11550139] Hepatogastroenterology. 2002 Jan-Feb;49(43):231-4 [11941962] Clin Cancer Res. 2002 Apr;8(4):995-1002 [11948105] Leukemia. 2002 May;16(5):865-73 [11986949] Am J Clin Pathol. 2003 Feb;119(2):213-7 [12579991] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1182/blood-2008-01-131987 ER - TY - JOUR T1 - Risk of cataract after exposure to low doses of ionizing radiation: a 20-year prospective cohort study among US radiologic technologists. AN - 69518332; 18664497 AB - The study aim was to determine the risk of cataract among radiologic technologists with respect to occupational and nonoccupational exposures to ionizing radiation and to personal characteristics. A prospective cohort of 35,705 cataract-free US radiologic technologists aged 24-44 years was followed for nearly 20 years (1983-2004) by using two follow-up questionnaires. During the study period, 2,382 cataracts and 647 cataract extractions were reported. Cigarette smoking for >or=5 pack-years; body mass index of >or=25 kg/m(2); and history of diabetes, hypertension, hypercholesterolemia, or arthritis at baseline were significantly (p or=3 x-rays to the face/neck was associated with a hazard ratio of cataract of 1.25 (95% confidence interval: 1.06, 1.47). For workers in the highest category (mean, 60 mGy) versus lowest category (mean, 5 mGy) of occupational dose to the lens of the eye, the adjusted hazard ratio of cataract was 1.18 (95% confidence interval: 0.99, 1.40). Findings challenge the National Council on Radiation Protection and International Commission on Radiological Protection assumptions that the lowest cumulative ionizing radiation dose to the lens of the eye that can produce a progressive cataract is approximately 2 Gy, and they support the hypothesis that the lowest cataractogenic dose in humans is substantially less than previously thought. JF - American journal of epidemiology AU - Chodick, Gabriel AU - Bekiroglu, Nural AU - Hauptmann, Michael AU - Alexander, Bruce H AU - Freedman, D Michal AU - Doody, Michele Morin AU - Cheung, Li C AU - Simon, Steven L AU - Weinstock, Robert M AU - Bouville, André AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7238, USA. hodik_g@mac.org.il Y1 - 2008/09/15/ PY - 2008 DA - 2008 Sep 15 SP - 620 EP - 631 VL - 168 IS - 6 KW - Index Medicus KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Confidence Intervals KW - Middle Aged KW - Follow-Up Studies KW - Dose-Response Relationship, Radiation KW - United States -- epidemiology KW - Male KW - Female KW - Proportional Hazards Models KW - Smoking -- adverse effects KW - Occupational Exposure -- adverse effects KW - Cataract -- etiology KW - Radiation, Ionizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69518332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Risk+of+cataract+after+exposure+to+low+doses+of+ionizing+radiation%3A+a+20-year+prospective+cohort+study+among+US+radiologic+technologists.&rft.au=Chodick%2C+Gabriel%3BBekiroglu%2C+Nural%3BHauptmann%2C+Michael%3BAlexander%2C+Bruce+H%3BFreedman%2C+D+Michal%3BDoody%2C+Michele+Morin%3BCheung%2C+Li+C%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BBouville%2C+Andr%C3%A9%3BSigurdson%2C+Alice+J&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2008-09-15&rft.volume=168&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn171 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Health Phys. 1995 May;68(5):632-42 [7730059] Am J Public Health. 1993 Apr;83(4):588-90 [8460743] Ophthalmic Res. 1996;28(4):237-47 [8878187] Br J Ophthalmol. 1997 Apr;81(4):261-6 [9215051] Arch Ophthalmol. 1997 Oct;115(10):1296-303 [9338677] Arch Ophthalmol. 1998 Feb;116(2):219-25 [9488275] Ophthalmology. 1998 Jul;105(7):1244-50 [9663229] JAMA. 1998 Aug 26;280(8):714-8 [9728643] Arch Ophthalmol. 2005 Aug;123(8):1102-5 [16087845] Eye (Lond). 2005 Oct;19(10):1074-82 [16304587] Health Phys. 2006 Feb;90(2):154-60 [16404173] Chest. 2006 Apr;129(4):933-41 [16608941] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] Radiat Res. 2007 Feb;167(2):233-43 [17390731] Arch Ophthalmol. 2002 Nov;120(11):1551-8 [12427071] Am J Epidemiol. 2003 Apr 1;157(7):652-63 [12672685] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Am J Public Health. 1999 Dec;89(12):1864-6 [10589319] Ophthalmic Epidemiol. 2000 Mar;7(1):61-5 [10652172] Ophthalmology. 2000 Jul;107(7):1267-73 [10889096] Invest Ophthalmol Vis Sci. 2000 Nov;41(12):3720-5 [11053268] Radiat Res. 2001 Jul;156(1):71-7 [11418075] Radiat Res. 2001 Nov;156(5 Pt 1):460-6 [11604058] Arch Ophthalmol. 2002 Jun;120(6):804-11 [12049587] Am J Ophthalmol. 2002 Aug;134(2):273-4 [12140040] Invest Ophthalmol Vis Sci. 2003 Jul;44(7):2905-8 [12824230] Ophthalmic Epidemiol. 2003 Oct;10(4):227-40 [14628965] Arch Ophthalmol. 2004 Apr;122(4):487-94 [15078665] Arch Ophthalmol. 2004 Apr;122(4):525-30 [15078670] Ophthalmology. 2004 May;111(5):914-20 [15121368] Arch Ophthalmol. 1967 Dec;78(6):697-704 [4863707] Am J Epidemiol. 1969 Feb;89(2):129-38 [5765953] Am J Ophthalmol. 1981 Mar;91(3):381-95 [7211996] Lancet. 1981 Dec 5;2(8258):1249-50 [6118668] Radiat Res. 1982 Dec;92(3):574-95 [7178422] Bull N Y Acad Med. 1983 May;59(4):372-92 [6575847] Am J Epidemiol. 1983 Aug;118(2):239-49 [6881129] Radiat Res. 1983 Dec;96(3):560-79 [6657922] Am J Infect Control. 1985 Apr;13(2):52-6 [3922254] Am J Epidemiol. 1986 Dec;124(6):916-25 [3776974] Science. 1988 Feb 12;239(4841 Pt 1):762-4 [3340857] Am J Epidemiol. 1991 Mar 15;133(6):541-53 [1672483] Cancer. 1992 Jan 15;69(2):586-98 [1728391] Epidemiol Rev. 1995;17(2):336-46 [8654515] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn171 ER - TY - JOUR T1 - First-trimester maternal alcohol consumption and the risk of infant oral clefts in Norway: a population-based case-control study. AN - 69517397; 18667525 AB - Although alcohol is a recognized teratogen, evidence is limited on alcohol intake and oral cleft risk. The authors examined the association between maternal alcohol consumption and oral clefts in a national, population-based case-control study of infants born in 1996-2001 in Norway. Participants were 377 infants with cleft lip with or without cleft palate, 196 with cleft palate only, and 763 controls. Mothers reported first-trimester alcohol consumption in self-administered questionnaires completed within a few months after delivery. Logistic regression was used to calculate odds ratios and 95% confidence intervals, adjusting for confounders. Compared with nondrinkers, women who reported binge-level drinking (>or=5 drinks per sitting) were more likely to have an infant with cleft lip with or without cleft palate (odds ratio = 2.2, 95% confidence interval: 1.1, 4.2) and cleft palate only (odds ratio = 2.6, 95% confidence interval: 1.2, 5.6). Odds ratios were higher among women who binged on three or more occasions: odds ratio = 3.2 for cleft lip with or without cleft palate (95% confidence interval: 1.0, 10.2) and odds ratio = 3.0 for cleft palate only (95% confidence interval: 0.7, 13.0). Maternal binge-level drinking may increase the risk of infant clefts. JF - American journal of epidemiology AU - DeRoo, Lisa A AU - Wilcox, Allen J AU - Drevon, Christian A AU - Lie, Rolv Terje AD - Epidemiology Branch, National Institute of Environmental Health Sciences/National Institutes of Health, Durham, NC 27709, USA. DeRooL@niehs.nih.gov Y1 - 2008/09/15/ PY - 2008 DA - 2008 Sep 15 SP - 638 EP - 646 VL - 168 IS - 6 KW - Index Medicus KW - Registries KW - Maternal Behavior KW - Pregnancy Trimester, First KW - Norway -- epidemiology KW - Logistic Models KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Infant, Newborn KW - Case-Control Studies KW - Female KW - Pregnancy KW - Cleft Palate -- etiology KW - Cleft Palate -- epidemiology KW - Alcohol Drinking -- adverse effects KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69517397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=First-trimester+maternal+alcohol+consumption+and+the+risk+of+infant+oral+clefts+in+Norway%3A+a+population-based+case-control+study.&rft.au=DeRoo%2C+Lisa+A%3BWilcox%2C+Allen+J%3BDrevon%2C+Christian+A%3BLie%2C+Rolv+Terje&rft.aulast=DeRoo&rft.aufirst=Lisa&rft.date=2008-09-15&rft.volume=168&rft.issue=6&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn186 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 2000 Mar;90(3):415-9 [10705862] Am J Epidemiol. 2007 Oct 1;166(7):775-85 [17609516] Ann Epidemiol. 2001 Aug;11(6):434-42 [11454503] Addiction. 2001 Nov;96(11):1575-88 [11784455] Alcohol Res Health. 2001;25(3):168-74 [11810954] Birth Defects Res A Clin Mol Teratol. 2003 Jul;67(7):509-14 [14565622] JAMA. 2003 Dec 10;290(22):2996-9 [14665662] N Engl J Med. 1978 May 11;298(19):1063-7 [347295] Am J Orthod. 1985 Jul;88(1):64-76 [3860013] Alcohol Clin Exp Res. 1988 Aug;12(4):506-11 [3056071] Am J Epidemiol. 1991 Oct 1;134(7):691-8 [1951274] Neurotoxicol Teratol. 1991 Sep-Oct;13(5):535-40 [1758408] Eur J Clin Nutr. 1992 Nov;46(11):809-21 [1425535] Int J Epidemiol. 1994 Dec;23(6):1218-25 [7721524] Reprod Toxicol. 1996 Jan-Feb;10(1):3-13 [8998383] Am J Clin Nutr. 1996 Sep;64(3):305-11 [8780338] Teratology. 1996 May;53(5):309-17 [8879089] Teratology. 1996 Jul;54(1):27-33 [8916367] Subst Use Misuse. 1998 Aug;33(10):2179-200 [9744846] Teratology. 1999 Jan;59(1):39-50 [9988882] J Pediatr. 1999 Mar;134(3):298-303 [10064665] Am J Epidemiol. 1999 Jul 1;150(1):75-87 [10400557] Alcohol Clin Exp Res. 2006 Mar;30(3):510-5 [16499492] Acta Obstet Gynecol Scand. 2006;85(11):1292-8 [17091405] Addiction. 2006 Dec;101(12):1711-8 [17156170] Eur J Epidemiol. 2007;22(3):173-81 [17295096] Eur J Neurol. 2000 Jul;7(4):413-21 [10971601] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn186 ER - TY - JOUR T1 - Characterization of a novel nonclassical T cell clone with broad reactivity against human renal cell carcinomas. AN - 69508661; 18768829 AB - A CD4(+) T cell clone (HC/2G-1) was established by stimulating peripheral blood T cells from a patient with renal cell carcinoma (RCC) with dendritic cells preincubated with the autologous apoptotic renal tumor line in the presence of IFN-alpha. It recognizes the autologous RCC and most allogeneic RCC lines by IFN-gamma release (10 of 11 lines) and lysis (9 of 10 lines), but does not recognize multiple EBV B cells or fibroblasts. It shows little or no recognition of a panel of melanomas, breast cancers and non-small-cell lung cancers. Phenotypically, HC/2G-1 is CD3(+)CD4(+) TCR alphabeta(+), but CD161(-)CD16(-)NKG2D(-). Tumor recognition by clone HC/2G-1 was not blocked by Abs to HLA class I or class II, but was significantly reduced by anti-TCR alphabeta Ab. Furthermore, tumor recognition was beta(2)-microglobulin-independent. HC/2G-1 does not use a Valpha or Vbeta described for classical NKT cells, but rather Valpha14 and Vbeta2.1. Allogeneic T cells cotransfected with mRNAs encoding the alpha and beta chains of the HC/2G-1 TCR recognized renal tumor lines, demonstrating that tumor recognition is TCR-mediated. Interestingly, TRAIL appears to play a role in tumor recognition by HC/2G-1 in that reactivity was blocked by anti-TRAIL Ab, and soluble TRAIL could enhance IFN-gamma secretion by HC/2G-1 in response to renal tumors. Our findings suggest that clone HC/2G-1 represents a novel type of CD4(+) cell that has broad TCR-mediated recognition of a determinant widely expressed by RCC. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Wang, Qiong J AU - Hanada, Ken-Ichi AU - Yang, James C AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/09/15/ PY - 2008 DA - 2008 Sep 15 SP - 3769 EP - 3776 VL - 181 IS - 6 KW - Antibodies, Blocking KW - 0 KW - Epitopes, T-Lymphocyte KW - Receptors, Antigen, T-Cell KW - TNF-Related Apoptosis-Inducing Ligand KW - Abridged Index Medicus KW - Index Medicus KW - Clone Cells KW - Coculture Techniques KW - Humans KW - Apoptosis -- immunology KW - Cell Line, Tumor KW - Epitopes, T-Lymphocyte -- immunology KW - TNF-Related Apoptosis-Inducing Ligand -- physiology KW - Antibodies, Blocking -- physiology KW - Cell Proliferation KW - Receptors, Antigen, T-Cell -- physiology KW - TNF-Related Apoptosis-Inducing Ligand -- immunology KW - Tumor Cells, Cultured KW - Lymphocyte Activation -- immunology KW - Cytotoxicity Tests, Immunologic KW - Cell Line, Transformed KW - TNF-Related Apoptosis-Inducing Ligand -- antagonists & inhibitors KW - T-Lymphocyte Subsets -- metabolism KW - Carcinoma, Renal Cell -- pathology KW - Kidney Neoplasms -- therapy KW - Kidney Neoplasms -- pathology KW - Carcinoma, Renal Cell -- therapy KW - T-Lymphocyte Subsets -- immunology KW - CD4-Positive T-Lymphocytes -- immunology KW - T-Lymphocyte Subsets -- pathology KW - Carcinoma, Renal Cell -- immunology KW - Kidney Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69508661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Characterization+of+a+novel+nonclassical+T+cell+clone+with+broad+reactivity+against+human+renal+cell+carcinomas.&rft.au=Wang%2C+Qiong+J%3BHanada%2C+Ken-Ichi%3BYang%2C+James+C&rft.aulast=Wang&rft.aufirst=Qiong&rft.date=2008-09-15&rft.volume=181&rft.issue=6&rft.spage=3769&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Mar 1;162(5):2639-47 [10072506] Annu Rev Immunol. 1998;16:359-93 [9597134] J Immunol. 2004 Dec 15;173(12):7209-16 [15585842] Nat Rev Immunol. 2005 Jun;5(6):459-71 [15928678] J Exp Med. 2005 Jun 20;201(12):1973-85 [15967825] Cancer Immunol Immunother. 2005 Aug;54(8):721-8 [16010587] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12855-60 [16123136] J Immunother. 2005 Nov-Dec;28(6):551-9 [16224272] J Exp Med. 2005 Nov 7;202(9):1279-88 [16275765] J Exp Med. 2005 Dec 5;202(11):1507-16 [16330814] Mol Ther. 2006 Jan;13(1):151-9 [16140584] J Exp Med. 2006 Jan 23;203(1):239-50 [16418392] Science. 2006 Oct 6;314(5796):126-9 [16946036] J Immunol. 1999 Dec 1;163(11):6330-7 [10570328] Nat Immunol. 2001 May;2(5):443-51 [11323699] Trends Immunol. 2001 May;22(5):269-76 [11323286] J Immunol. 2001 Aug 1;167(3):1347-52 [11466352] Nature. 2003 Feb 20;421(6925):852-6 [12594515] Science. 2003 Apr 11;300(5617):337-9 [12690201] J Clin Oncol. 2003 Aug 15;21(16):3127-32 [12915604] Nat Immunol. 2003 Oct;4(10):1009-15 [14502286] Nat Med. 2003 Nov;9(11):1377-82 [14528297] Cancer Immunol Immunother. 2004 Mar;53(3):176-86 [14685782] J Immunother. 2004 May-Jun;27(3):184-90 [15076135] Kidney Int. 1984 Feb;25(2):383-90 [6727133] Proc Natl Acad Sci U S A. 1989 Sep;86(18):7159-63 [2674949] J Immunol. 1998 Apr 1;160(7):3111-20 [9531265] J Exp Med. 1999 May 3;189(9):1451-60 [10224285] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition. AN - 69412088; 18590744 AB - C-C chemokine receptor 5 (CCR5), a member of G-protein-coupled receptors, serves as a coreceptor for human immunodeficiency virus type 1 (HIV-1). In the present study, we examined the interactions between CCR5 and novel CCR5 inhibitors containing the spirodiketopiperazine scaffolds AK530 and AK317, both of which were lodged in the hydrophobic cavity located between the upper transmembrane domain and the second extracellular loop (ECL2) of CCR5. Although substantial differences existed between the two inhibitors--AK530 had 10-fold-greater CCR5-binding affinity (K(d)=1.4 nM) than AK317 (16.7 nM)-their antiviral potencies were virtually identical (IC(50)=2.1 nM and 1.5 nM, respectively). Molecular dynamics simulations for unbound CCR5 showed hydrogen bond interactions among transmembrane residues Y108, E283, and Y251, which were crucial for HIV-1-gp120/sCD4 complex binding and HIV-1 fusion. Indeed, AK530 and AK317, when bound to CCR5, disrupted these interhelix hydrogen bond interactions, a salient molecular mechanism enabling allosteric inhibition. Mutagenesis and structural analysis showed that ECL2 consists of a part of the hydrophobic cavity for both inhibitors, although AK317 is more tightly engaged with ECL2 than AK530, explaining their similar anti-HIV-1 potencies despite the difference in K(d) values. We also found that amino acid residues in the beta-hairpin structural motif of ECL2 are critical for HIV-1-elicited fusion and binding of the spirodiketopiperazine-based inhibitors to CCR5. The direct ECL2-engaging property of the inhibitors likely produces an ECL2 conformation, which HIV-1 gp120 cannot bind to, but also prohibits HIV-1 from utilizing the "inhibitor-bound" CCR5 for cellular entry--a mechanism of HIV-1's resistance to CCR5 inhibitors. The data should not only help delineate the dynamics of CCR5 following inhibitor binding but also aid in designing CCR5 inhibitors that are more potent against HIV-1 and prevent or delay the emergence of resistant HIV-1 variants. JF - Journal of molecular biology AU - Maeda, Kenji AU - Das, Debananda AU - Yin, Philip D AU - Tsuchiya, Kiyoto AU - Ogata-Aoki, Hiromi AU - Nakata, Hirotomo AU - Norman, Rachael B AU - Hackney, Lauren A AU - Takaoka, Yoshikazu AU - Mitsuya, Hiroaki AD - Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/09/12/ PY - 2008 DA - 2008 Sep 12 SP - 956 EP - 974 VL - 381 IS - 4 KW - Antibodies, Monoclonal KW - 0 KW - CCR5 Receptor Antagonists KW - HIV Envelope Protein gp120 KW - Ligands KW - Mutant Proteins KW - Receptors, CCR5 KW - Tritium KW - 10028-17-8 KW - Index Medicus KW - Animals KW - Protein Structure, Secondary KW - Computer Simulation KW - Cricetulus KW - Models, Molecular KW - Mutant Proteins -- metabolism KW - Humans KW - Amino Acid Sequence KW - HIV Envelope Protein gp120 -- metabolism KW - Structure-Activity Relationship KW - Cell Fusion KW - Molecular Sequence Data KW - CHO Cells KW - Allosteric Regulation KW - Protein Structure, Tertiary KW - Amino Acid Substitution KW - Cricetinae KW - HIV-1 -- metabolism KW - Extracellular Space -- metabolism KW - Receptors, CCR5 -- chemistry KW - Cell Membrane -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69412088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Involvement+of+the+second+extracellular+loop+and+transmembrane+residues+of+CCR5+in+inhibitor+binding+and+HIV-1+fusion%3A+insights+into+the+mechanism+of+allosteric+inhibition.&rft.au=Maeda%2C+Kenji%3BDas%2C+Debananda%3BYin%2C+Philip+D%3BTsuchiya%2C+Kiyoto%3BOgata-Aoki%2C+Hiromi%3BNakata%2C+Hirotomo%3BNorman%2C+Rachael+B%3BHackney%2C+Lauren+A%3BTakaoka%2C+Yoshikazu%3BMitsuya%2C+Hiroaki&rft.aulast=Maeda&rft.aufirst=Kenji&rft.date=2008-09-12&rft.volume=381&rft.issue=4&rft.spage=956&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/10.1016%2Fj.jmb.2008.06.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-05 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1996 Jun 28;272(5270):1955-8 [8658171] Mol Pharmacol. 2008 Mar;73(3):789-800 [18096812] Science. 1996 Nov 1;274(5288):768-70 [8864113] Nature. 1996 Nov 14;384(6605):179-83 [8906795] Nature. 1996 Nov 14;384(6605):184-7 [8906796] J Biol Chem. 1997 Oct 3;272(40):24934-41 [9312096] J Virol. 2000 Feb;74(4):1787-93 [10644351] J Virol. 2000 Apr;74(8):3740-51 [10729149] Proc Natl Acad Sci U S A. 2000 May 9;97(10):5639-44 [10779565] Science. 2000 Aug 4;289(5480):739-45 [10926528] J Biol Chem. 2001 Aug 3;276(31):29171-7 [11375997] J Mol Biol. 2001 Aug 10;311(2):421-30 [11478870] J Biol Chem. 2001 Sep 14;276(37):35194-200 [11454872] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):395-400 [11782552] J Exp Med. 1997 Oct 20;186(8):1373-81 [9334377] J Biol Chem. 1998 Jul 17;273(29):17979-82 [9660746] J Biol Chem. 1999 Jan 22;274(4):1905-13 [9890944] Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5982-7 [11972040] J Virol. 2002 Sep;76(17):8953-7 [12163614] J Virol. 2003 May;77(9):5201-8 [12692222] N Engl J Med. 2003 May 29;348(22):2228-38 [12773651] J Virol. 2004 Mar;78(6):2790-807 [14990699] J Med Chem. 2004 Mar 25;47(7):1739-49 [15027865] Proteins. 2004 May 1;55(2):351-67 [15048827] J Med Chem. 2004 May 6;47(10):2405-8 [15115380] J Virol. 2004 Aug;78(16):8654-62 [15280474] J Mol Biol. 2004 Sep 10;342(2):571-83 [15327956] Science. 1986 Jul 11;233(4760):215-9 [3014648] Science. 1988 Sep 23;241(4873):1673-5 [3047875] J Virol. 1992 Apr;66(4):2232-9 [1548759] Nature. 1996 Jun 20;381(6584):661-6 [8649511] J Biol Chem. 1999 Apr 2;274(14):9617-26 [10092648] J Virol. 1999 May;73(5):4145-55 [10196311] Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703 [10318947] J Virol. 2005 Feb;79(4):2087-96 [15681411] Mol Pharmacol. 2005 Apr;67(4):1268-82 [15644495] Virology. 2005 Jul 20;338(1):182-99 [15935415] Antimicrob Agents Chemother. 2005 Nov;49(11):4708-15 [16251315] Antimicrob Agents Chemother. 2005 Nov;49(11):4721-32 [16251317] Nat Med. 2005 Nov;11(11):1170-2 [16205738] Science. 2005 Nov 11;310(5750):1025-8 [16284180] J Med Chem. 2006 Jan 26;49(2):534-53 [16420040] J Med Chem. 2006 Mar 23;49(6):2037-48 [16539392] J Med Chem. 2006 May 4;49(9):2784-93 [16640339] J Biol Chem. 2006 May 5;281(18):12688-98 [16476734] Virology. 2006 May 25;349(1):41-54 [16494916] Curr Top Med Chem. 2006;6(13):1319-33 [16918451] J Med Chem. 2006 Oct 19;49(21):6177-96 [17034125] Antimicrob Agents Chemother. 2007 Feb;51(2):707-15 [17116673] Bioorg Med Chem Lett. 2007 Feb 1;17(3):727-31 [17118654] J Virol. 2007 Mar;81(5):2359-71 [17182681] Virology. 2007 Apr 25;361(1):212-28 [17166540] Nature. 2007 Nov 15;450(7168):383-7 [17952055] J Biol Chem. 1996 Jul 19;271(29):17161-6 [8663314] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jmb.2008.06.041 ER - TY - JOUR T1 - Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury. AN - 69364162; 18586006 AB - Recent studies in mice suggest that stress-activated c-Jun N-terminal protein kinase 2 (JNK2) plays a pathologic role in acetaminophen (APAP)-induced liver injury (AILI), a major cause of acute liver failure (ALF). In contrast, we present evidence that JNK2 can have a protective role against AILI. When male C57BL/6J wild type (WT) and JNK2(-/-) mice were treated with 300mg APAP/kg, 90% of JNK2(-/-) mice died of ALF compared to 20% of WT mice within 48h. The high susceptibility of JNK2(-/-) mice to AILI appears to be due in part to deficiencies in hepatocyte proliferation and repair. Therefore, our findings are consistent with JNK2 signaling playing a protective role in AILI and further suggest that the use of JNK inhibitors as a potential treatment for AILI, as has been recommended by other investigators, should be reconsidered. JF - Biochemical and biophysical research communications AU - Bourdi, Mohammed AU - Korrapati, Midhun C AU - Chakraborty, Mala AU - Yee, Steven B AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1760, USA. bourdim@nih.gov Y1 - 2008/09/12/ PY - 2008 DA - 2008 Sep 12 SP - 6 EP - 10 VL - 374 IS - 1 KW - Analgesics, Non-Narcotic KW - 0 KW - Cyclin D KW - Cyclins KW - Acetaminophen KW - 362O9ITL9D KW - Mitogen-Activated Protein Kinase 9 KW - EC 2.7.1.24 KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Cyclins -- metabolism KW - Mice KW - Liver Regeneration -- genetics KW - Male KW - Mitogen-Activated Protein Kinase 9 -- genetics KW - Liver Failure, Acute -- genetics KW - Liver Failure, Acute -- chemically induced KW - Liver -- pathology KW - Liver -- enzymology KW - Liver -- drug effects KW - Mitogen-Activated Protein Kinase 9 -- physiology KW - Analgesics, Non-Narcotic -- toxicity KW - Liver Failure, Acute -- enzymology KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69364162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Protective+role+of+c-Jun+N-terminal+kinase+2+in+acetaminophen-induced+liver+injury.&rft.au=Bourdi%2C+Mohammed%3BKorrapati%2C+Midhun+C%3BChakraborty%2C+Mala%3BYee%2C+Steven+B%3BPohl%2C+Lance+R&rft.aulast=Bourdi&rft.aufirst=Mohammed&rft.date=2008-09-12&rft.volume=374&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=1090-2104&rft_id=info:doi/10.1016%2Fj.bbrc.2008.06.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-25 N1 - Date created - 2008-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Pharmacol. 1987 Apr 15;36(8):1193-6 [3593409] Hepatology. 2004 Jul;40(1):23-6 [15239082] J Clin Invest. 1995 Feb;95(2):803-10 [7860764] EMBO J. 1999 Jan 4;18(1):188-97 [9878062] Br J Pharmacol. 1999 Aug;127(7):1589-96 [10455314] Endocrinology. 2004 Dec;145(12):5439-47 [15331580] Toxicol Pathol. 2005;33(1):41-51 [15805055] Nat Rev Drug Discov. 2005 Jun;4(6):489-99 [15931258] Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Life Sci. 2006 Mar 6;78(15):1670-6 [16226279] Gastroenterology. 2006 Jul;131(1):165-78 [16831600] Gastroenterology. 2006 Jul;131(1):314-6 [16831613] Transplantation. 2006 Jul 27;82(2):241-50 [16858288] Exp Mol Med. 2006 Aug 31;38(4):408-16 [16953120] Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1536-44 [16489107] Mol Cell. 2006 Sep 15;23(6):899-911 [16973441] J Biochem Mol Biol. 2006 Sep 30;39(5):479-91 [17002867] Microbiol Mol Biol Rev. 2006 Dec;70(4):1061-95 [17158707] Chem Res Toxicol. 2007 Feb;20(2):208-16 [17305405] Hepatology. 2007 Feb;45(2):412-21 [17366662] Eur J Pharmacol. 2007 Jun 14;564(1-3):190-5 [17395177] Chem Res Toxicol. 2007 May;20(5):734-44 [17439248] Gut. 2007 Jul;56(7):982-90 [17185352] J Nutr Sci Vitaminol (Tokyo). 2007 Apr;53(2):160-5 [17616004] J Cell Physiol. 2007 Nov;213(2):286-300 [17559071] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] Hepatology. 2008 Sep;48(3):889-97 [18712839] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6 [11287661] J Pharmacol Exp Ther. 2001 Jun;297(3):946-52 [11356915] Hepatology. 2002 Feb;35(2):289-98 [11826401] Biochem Biophys Res Commun. 2002 Jun 7;294(2):225-30 [12051698] Toxicol Appl Pharmacol. 2002 Jun 1;181(2):106-15 [12051994] FASEB J. 2002 Aug;16(10):1227-36 [12153990] Biochem J. 2003 Apr 1;371(Pt 1):199-204 [12534346] Hepatology. 2003 Apr;37(4):824-32 [12668975] Am J Physiol Gastrointest Liver Physiol. 2003 Jun;284(6):G875-9 [12736142] J Biol Chem. 2003 Jun 20;278(25):22243-9 [12646564] Toxicol Lett. 2003 Oct 15;144(3):279-88 [12927346] Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G959-66 [12842828] Drug Metab Dispos. 2003 Dec;31(12):1499-506 [14625346] Biochim Biophys Acta. 2004 Mar 11;1697(1-2):89-101 [15023353] Hepatology. 2004 May;39(5):1267-76 [15122755] Cancer Treat Res. 2004;119:217-37 [15164880] Cancer Lett. 1991 Sep;59(3):251-6 [1680544] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbrc.2008.06.065 ER - TY - JOUR T1 - Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. AN - 69531983; 18765795 AB - Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). To investigate whether these DLBCL subtypes arise by distinct pathogenetic mechanisms, we analyzed 203 DLBCL biopsy samples by high-resolution, genome-wide copy number analysis coupled with gene-expression profiling. Of 272 recurrent chromosomal aberrations that were associated with gene-expression alterations, 30 were used differentially by the DLBCL subtypes (P < 0.006). An amplicon on chromosome 19 was detected in 26% of ABC DLBCLs but in only 3% of GCB DLBCLs and PMBLs. A highly up-regulated gene in this amplicon was SPIB, which encodes an ETS family transcription factor. Knockdown of SPIB by RNA interference was toxic to ABC DLBCL cell lines but not to GCB DLBCL, PMBL, or myeloma cell lines, strongly implicating SPIB as an oncogene involved in the pathogenesis of ABC DLBCL. Deletion of the INK4a/ARF tumor suppressor locus and trisomy 3 also occurred almost exclusively in ABC DLBCLs and was associated with inferior outcome within this subtype. FOXP1 emerged as a potential oncogene in ABC DLBCL that was up-regulated by trisomy 3 and by more focal high-level amplifications. In GCB DLBCL, amplification of the oncogenic mir-17-92 microRNA cluster and deletion of the tumor suppressor PTEN were recurrent, but these events did not occur in ABC DLBCL. Together, these data provide genetic evidence that the DLBCL subtypes are distinct diseases that use different oncogenic pathways. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Lenz, Georg AU - Wright, George W AU - Emre, N C Tolga AU - Kohlhammer, Holger AU - Dave, Sandeep S AU - Davis, R Eric AU - Carty, Shannon AU - Lam, Lloyd T AU - Shaffer, A L AU - Xiao, Wenming AU - Powell, John AU - Rosenwald, Andreas AU - Ott, German AU - Muller-Hermelink, Hans Konrad AU - Gascoyne, Randy D AU - Connors, Joseph M AU - Campo, Elias AU - Jaffe, Elaine S AU - Delabie, Jan AU - Smeland, Erlend B AU - Rimsza, Lisa M AU - Fisher, Richard I AU - Weisenburger, Dennis D AU - Chan, Wing C AU - Staudt, Louis M AD - Metabolism Branch, Biometric Research Branch, Center for Information Technology, and Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. lstaudt@mail.nih.gov Y1 - 2008/09/09/ PY - 2008 DA - 2008 Sep 09 SP - 13520 EP - 13525 VL - 105 IS - 36 KW - Oncogene Proteins KW - 0 KW - Tumor Suppressor Proteins KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Gene Expression Profiling KW - Humans KW - Tumor Suppressor Proteins -- metabolism KW - Genome, Human -- genetics KW - Tumor Suppressor Proteins -- genetics KW - Prognosis KW - Chromosome Aberrations KW - Oncogene Proteins -- genetics KW - Biopsy KW - Oncogene Proteins -- metabolism KW - Cell Survival KW - Lymphoma, Large B-Cell, Diffuse -- pathology KW - Lymphoma, Large B-Cell, Diffuse -- metabolism KW - Lymphoma, Large B-Cell, Diffuse -- genetics KW - Lymphoma, Large B-Cell, Diffuse -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69531983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Molecular+subtypes+of+diffuse+large+B-cell+lymphoma+arise+by+distinct+genetic+pathways.&rft.au=Lenz%2C+Georg%3BWright%2C+George+W%3BEmre%2C+N+C+Tolga%3BKohlhammer%2C+Holger%3BDave%2C+Sandeep+S%3BDavis%2C+R+Eric%3BCarty%2C+Shannon%3BLam%2C+Lloyd+T%3BShaffer%2C+A+L%3BXiao%2C+Wenming%3BPowell%2C+John%3BRosenwald%2C+Andreas%3BOtt%2C+German%3BMuller-Hermelink%2C+Hans+Konrad%3BGascoyne%2C+Randy+D%3BConnors%2C+Joseph+M%3BCampo%2C+Elias%3BJaffe%2C+Elaine+S%3BDelabie%2C+Jan%3BSmeland%2C+Erlend+B%3BRimsza%2C+Lisa+M%3BFisher%2C+Richard+I%3BWeisenburger%2C+Dennis+D%3BChan%2C+Wing+C%3BStaudt%2C+Louis+M&rft.aulast=Lenz&rft.aufirst=Georg&rft.date=2008-09-09&rft.volume=105&rft.issue=36&rft.spage=13520&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0804295105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30 [15983384] Blood. 2005 Nov 1;106(9):3183-90 [16046532] Adv Immunol. 2005;87:163-208 [16102574] Blood. 2005 Sep 1;106(5):1770-7 [15886317] Cancer Res. 2004 May 1;64(9):3087-95 [15126345] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9067-72 [15199222] Blood. 1997 Jun 1;89(11):3909-18 [9166827] EMBO J. 1997 Dec 1;16(23):7118-29 [9384589] Blood. 1998 Dec 1;92(11):4487-9 [9882102] Cancer Res. 2000 Feb 1;60(3):549-52 [10676635] Nature. 2000 Feb 3;403(6769):503-11 [10676951] Curr Opin Oncol. 2001 Sep;13(5):325-34 [11555708] J Exp Med. 2001 Dec 17;194(12):1861-74 [11748286] N Engl J Med. 2002 Jun 20;346(25):1937-47 [12075054] Nat Rev Immunol. 2002 Dec;2(12):920-32 [12461565] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9991-6 [12900505] J Exp Med. 2003 Sep 15;198(6):851-62 [12975453] Blood. 2003 Dec 1;102(12):3871-9 [12933571] Clin Cancer Res. 2005 Jan 1;11(1):28-40 [15671525] J Biol Chem. 2005 Mar 4;280(9):7444-51 [15618216] Leukemia. 2005 Apr;19(4):652-8 [15703784] Nature. 2005 Jun 9;435(7043):839-43 [15944709] Blood. 2006 Mar 15;107(6):2477-85 [16317097] Nature. 2006 May 4;441(7089):106-10 [16572121] N Engl J Med. 2006 Jun 8;354(23):2419-30 [16760442] Leukemia. 2006 Jul;20(7):1300-3 [16673020] Nature. 2006 Nov 23;444(7118):444-54 [17122850] Nat Genet. 2007 Mar;39(3):347-51 [17293865] J Exp Med. 2007 Mar 19;204(3):633-43 [17353367] Trends Biochem Sci. 2007 Nov;32(11):509-19 [17949986] Science. 2008 Mar 21;319(5870):1676-9 [18323416] Blood. 2008 Apr 1;111(7):3701-13 [18160665] Leukemia. 2005 Aug;19(8):1299-305 [15944719] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0804295105 ER - TY - JOUR T1 - Regulating antibody diversity: taming a mutagen. AN - 69522149; 18775319 AB - In a recent issue of Molecular Cell, Conticello et al. (2008) identified a protein that interacts with the activation-induced deaminase protein and affects somatic hypermutation, class switching, and gene conversion in immunoglobulin genes, possibly via the spliceosome transcription complex. JF - Molecular cell AU - Gearhart, Patricia J AU - Sen, Ranjan AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA. gearhartp@grc.nia.nih.gov Y1 - 2008/09/05/ PY - 2008 DA - 2008 Sep 05 SP - 615 EP - 616 VL - 31 IS - 5 KW - Apoptosis Regulatory Proteins KW - 0 KW - CTNNBL1 protein, human KW - Immunoglobulin Heavy Chains KW - Immunoglobulin Variable Region KW - Nuclear Proteins KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Index Medicus KW - Immunoglobulin Variable Region -- genetics KW - Immunoglobulin Heavy Chains -- immunology KW - Gene Conversion KW - Humans KW - Immunoglobulin Variable Region -- immunology KW - Genes, Immunoglobulin KW - Transcription, Genetic KW - Immunoglobulin Heavy Chains -- genetics KW - Somatic Hypermutation, Immunoglobulin KW - Apoptosis Regulatory Proteins -- immunology KW - Nuclear Proteins -- genetics KW - Apoptosis Regulatory Proteins -- genetics KW - Immunoglobulin Class Switching -- genetics KW - Cytidine Deaminase -- immunology KW - Nuclear Proteins -- immunology KW - Cytidine Deaminase -- genetics KW - Antibody Diversity -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69522149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=Regulating+antibody+diversity%3A+taming+a+mutagen.&rft.au=Gearhart%2C+Patricia+J%3BSen%2C+Ranjan&rft.aulast=Gearhart&rft.aufirst=Patricia&rft.date=2008-09-05&rft.volume=31&rft.issue=5&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=1097-4164&rft_id=info:doi/10.1016%2Fj.molcel.2008.08.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Mol Cell. 2008 Aug 22;31(4):474-84 [18722174] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.molcel.2008.08.016 ER - TY - JOUR T1 - A Sox10 expression screen identifies an amino acid essential for Erbb3 function. AN - 69517827; 18773073 AB - The neural crest (NC) is a population of embryonic stem cells that gives rise to numerous cell types, including the glia and neurons of the peripheral and enteric nervous systems and the melanocytes of the skin and hair. Mutations in genes and genetic pathways regulating NC development lead to a wide spectrum of human developmental disorders collectively called neurocristopathies. To identify molecular pathways regulating NC development and to understand how alterations in these processes lead to disease, we established an N-ethyl-N-nitrosourea (ENU) mutagenesis screen utilizing a mouse model sensitized for NC defects, Sox10(LacZ/+). Out of 71 pedigrees analyzed, we identified and mapped four heritable loci, called modifier of Sox10 expression pattern 1-4 (msp1-4), which show altered NC patterning. In homozygous msp1 embryos, Sox10(LacZ) expression is absent in cranial ganglia, cranial nerves, and the sympathetic chain; however, the development of other Sox10-expressing cells appears unaffected by the mutation. Linkage analysis, sequencing, and complementation testing confirmed that msp1 is a new allele of the receptor tyrosine kinase Erbb3, Erbb3(msp1), that carries a single amino acid substitution in the extracellular region of the protein. The ENU-induced mutation does not alter protein expression, however, it is sufficient to impair ERBB3 signaling such that the embryonic defects observed in msp1 resemble those of Erbb3 null alleles. Biochemical analysis of the mutant protein showed that ERBB3 is expressed on the cell surface, but its ligand-induced phosphorylation is dramatically reduced by the msp1 mutation. These findings highlight the importance of the mutated residue for ERBB3 receptor function and activation. This study underscores the utility of using an ENU mutagenesis to identify genetic pathways regulating NC development and to dissect the roles of discrete protein domains, both of which contribute to a better understanding of gene function in a cellular and developmental setting. JF - PLoS genetics AU - Buac, Kristina AU - Watkins-Chow, Dawn E AU - Loftus, Stacie K AU - Larson, Denise M AU - Incao, Arturo AU - Gibney, Gretchen AU - Pavan, William J AD - Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America. Y1 - 2008/09/05/ PY - 2008 DA - 2008 Sep 05 SP - 1 VL - 4 IS - 9 KW - Amino Acids KW - 0 KW - DNA-Binding Proteins KW - High Mobility Group Proteins KW - RNA, Messenger KW - SOX10 protein, human KW - SOXE Transcription Factors KW - Sox10 protein, mouse KW - Transcription Factors KW - Receptor, ErbB-3 KW - EC 2.7.10.1 KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Animals KW - Humans KW - Amino Acids -- genetics KW - Gene Expression KW - Amino Acid Sequence KW - Mice KW - Mice, Inbred BALB C KW - Phenotype KW - Alleles KW - Base Sequence KW - RNA, Messenger -- metabolism KW - Phosphorylation KW - Neural Crest -- embryology KW - Molecular Sequence Data KW - Mice, Inbred C57BL KW - Amino Acids -- metabolism KW - Neural Crest -- metabolism KW - Mutation KW - Neural Crest -- cytology KW - Ethylnitrosourea -- pharmacology KW - Receptor, ErbB-3 -- metabolism KW - High Mobility Group Proteins -- genetics KW - Transcription Factors -- metabolism KW - Receptor, ErbB-3 -- genetics KW - DNA-Binding Proteins -- genetics KW - Transcription Factors -- genetics KW - High Mobility Group Proteins -- metabolism KW - Amino Acid Substitution KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69517827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+genetics&rft.atitle=A+Sox10+expression+screen+identifies+an+amino+acid+essential+for+Erbb3+function.&rft.au=Buac%2C+Kristina%3BWatkins-Chow%2C+Dawn+E%3BLoftus%2C+Stacie+K%3BLarson%2C+Denise+M%3BIncao%2C+Arturo%3BGibney%2C+Gretchen%3BPavan%2C+William+J&rft.aulast=Buac&rft.aufirst=Kristina&rft.date=2008-09-05&rft.volume=4&rft.issue=9&rft.spage=e1000177&rft.isbn=&rft.btitle=&rft.title=PLoS+genetics&rft.issn=1553-7404&rft_id=info:doi/10.1371%2Fjournal.pgen.1000177 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-11 N1 - Date created - 2008-09-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 1998 Jan;18(1):60-4 [9425902] Genes Dev. 2001 Jan 1;15(1):66-78 [11156606] Mamm Genome. 1998 Feb;9(2):150-4 [9457677] Nat Genet. 1998 Feb;18(2):171-3 [9462749] J Biol Chem. 1998 Jun 26;273(26):16050-7 [9632656] Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7485-90 [9636176] Nucleic Acids Res. 1999 Mar 15;27(6):1409-20 [10037800] Development. 1999 Apr;126(8):1601-9 [10079223] Hum Mol Genet. 1999 Sep;8(9):1785-9 [10441344] Neuron. 2005 Feb 17;45(4):513-23 [15721238] Mech Dev. 2005 May;122(5):659-69 [15817223] Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9 [15755804] Mol Cell Biol. 2005 Sep;25(17):7734-42 [16107719] J Biol. 2005;4(3):10 [16492316] Hum Mol Genet. 2007 Dec 15;16(24):3037-46 [17855451] J Biol Chem. 2008 Mar 28;283(13):8229-36 [18216017] Hum Mol Genet. 2008 Jul 15;17(14):2118-31 [18397875] Am J Hum Genet. 2000 May;66(5):1496-503 [10762540] Hum Genet. 2000 Jul;107(1):1-6 [10982026] Development. 2000 Dec;127(24):5379-89 [11076759] J Med Genet. 2001 Sep;38(9):E30 [11546831] Nat Genet. 2002 Feb;30(2):185-9 [11818962] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4471-6 [11917121] Science. 2002 Aug 23;297(5585):1330-3 [12154198] Cell. 2002 Sep 20;110(6):763-73 [12297049] Cell. 2002 Sep 20;110(6):775-87 [12297050] Neuron. 2003 Apr 10;38(1):17-31 [12691661] Development. 2003 Jun;130(12):2809-18 [12736222] Mol Biol Cell. 2003 Jul;14(7):2756-67 [12857862] PLoS Biol. 2004 Aug;2(8):E219 [15314648] Int Rev Cytol. 1986;103:89-145 [3528022] Dev Biol. 1987 May;121(1):220-36 [3552788] Proc Natl Acad Sci U S A. 1990 Jul;87(13):4905-9 [2164210] Nature. 1991 Dec 19-26;354(6354):526-8 [1722027] J Biol Chem. 1994 May 20;269(20):14661-5 [7514177] J Biol Chem. 1994 May 13;269(19):14303-6 [8188716] Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8132-6 [8058768] Nature. 1995 Nov 23;378(6555):386-90 [7477375] Proteins. 1995 Nov;23(3):318-26 [8710825] Nature. 1997 Oct 16;389(6652):725-30 [9338783] Development. 1997 Sep;124(18):3575-86 [9342050] J Neurosci. 1998 Jan 1;18(1):237-50 [9412504] Development. 1997 Dec;124(24):4999-5011 [9362461] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pgen.1000177 ER - TY - JOUR T1 - BMP7 reduces synergistic injury induced by methamphetamine and ischemia in mouse brain. AN - 69361763; 18598737 AB - Previous studies have indicated that methamphetamine (MA) potentiates neurodegeneration induced by ischemia in brain. We, and others, have reported that bone morphogenetic protein 7 (BMP7) is protective against MA and ischemic brain injury. The purpose of this study is to examine whether BMP7 reduces synergistic injury induced by both MA and cerebral ischemia. Adult CD-1 mice were treated with MA (4x 10mg/kg, each dose 2h apart) or saline. Using the quantitative real time polymerase chain reaction, we found that MA suppressed the expression of BMP7 mRNA in the cerebral cortex 1 day after injection. Ischemic and reperfusional injuries were introduced by ligation of the right middle cerebral artery for 90min after MA injection. Animals were sacrificed for caspase-3/7 activity assay and tri-phenyl-tetrazolium chloride staining at 1h and 2 days after reperfusion, respectively. Cerebral infarction and caspase-3/7 activity were enhanced in the stroke animals pretreated with MA; both responses were attenuated by pretreatment with BMP7. In conclusion, our data suggest that MA facilitates cerebral infarction after ischemia possibly mediated, in part, through the suppression of BMP7. JF - Neuroscience letters AU - Shen, Hui AU - Luo, Yu AU - Kuo, Chi-Chung AU - Wang, Yun AD - National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, United States. Y1 - 2008/09/05/ PY - 2008 DA - 2008 Sep 05 SP - 15 EP - 18 VL - 442 IS - 1 SN - 0304-3940, 0304-3940 KW - Bone Morphogenetic Protein 7 KW - 0 KW - Bone Morphogenetic Proteins KW - Dopamine Agents KW - Transforming Growth Factor beta KW - Methamphetamine KW - 44RAL3456C KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 7 KW - Index Medicus KW - Animals KW - Caspase 3 -- drug effects KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Caspase 7 -- drug effects KW - Male KW - Injections, Intraventricular KW - Transforming Growth Factor beta -- administration & dosage KW - Gene Expression -- drug effects KW - Dopamine Agents -- toxicity KW - Brain Ischemia -- pathology KW - Bone Morphogenetic Proteins -- metabolism KW - Bone Morphogenetic Proteins -- administration & dosage KW - Transforming Growth Factor beta -- metabolism KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69361763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=BMP7+reduces+synergistic+injury+induced+by+methamphetamine+and+ischemia+in+mouse+brain.&rft.au=Shen%2C+Hui%3BLuo%2C+Yu%3BKuo%2C+Chi-Chung%3BWang%2C+Yun&rft.aulast=Shen&rft.aufirst=Hui&rft.date=2008-09-05&rft.volume=442&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2008.06.052 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-14 N1 - Date created - 2008-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 1997 Jun 1;17(11):4341-8 [9151750] Cell Tissue Res. 1996 Nov;286(2):269-79 [8854897] Neuroreport. 1998 Nov 16;9(16):3615-21 [9858369] Stroke. 1999 Jan;30(1):126-33 [9880400] J Emerg Med. 1999 May-Jun;17(3):469-71 [10338241] J Neurol Sci. 2006 Jan 15;240(1-2):21-9 [16236321] Neuroscience. 2008 Jan 2;151(1):92-103 [18082966] Acta Neurochir Suppl. 2008;101:93-8 [18642641] Neuroscience. 2000;100(1):33-43 [10996456] Stroke. 2001 Mar;32(3):775-82 [11239201] Neuropharmacology. 2002 Sep;43(3):418-26 [12243771] Stroke. 2003 Feb;34(2):558-64 [12574575] FASEB J. 2003 Oct;17(13):1775-88 [14519657] Neurology. 1988 Apr;38(4):589-92 [3352918] Stroke. 1993 Feb;24(2):310-3 [8421834] Eur Neurol. 1994;34(1):16-22 [8137834] Neurosci Lett. 1995 Feb 24;187(1):21-4 [7617293] J Neurosci. 1998 May 15;18(10):3659-68 [9570797] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2008.06.052 ER - TY - JOUR T1 - The MYCN oncogene is a direct target of miR-34a. AN - 69513191; 18504438 AB - Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an aggressive phenotype. Database searches identified five microRNAs that map to the commonly deleted region of 1p36 and we hypothesized that the loss of one or more of these microRNAs contributes to the malignant phenotype of MYCN-amplified tumors. By bioinformatic analysis, we identified that three out of the five microRNAs target MYCN and of these miR-34a caused the most significant suppression of cell growth through increased apoptosis and decreased DNA synthesis in neuroblastoma cell lines with MYCN amplification. Quantitative RT-PCR showed that neuroblastoma tumors with 1p36 loss expressed lower level of miR-34a than those with normal copies of 1p36. Furthermore, we demonstrated that MYCN is a direct target of miR-34a. Finally, using a series of mRNA expression profiling experiments, we identified other potential direct targets of miR-34a, and pathway analysis demonstrated that miR-34a suppresses cell-cycle genes and induces several neural-related genes. This study demonstrates one important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma. JF - Oncogene AU - Wei, J S AU - Song, Y K AU - Durinck, S AU - Chen, Q-R AU - Cheuk, A T C AU - Tsang, P AU - Zhang, Q AU - Thiele, C J AU - Slack, A AU - Shohet, J AU - Khan, J AD - Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20892, USA. Y1 - 2008/09/04/ PY - 2008 DA - 2008 Sep 04 SP - 5204 EP - 5213 VL - 27 IS - 39 KW - DNA Primers KW - 0 KW - MYCN protein, human KW - MicroRNAs KW - N-Myc Proto-Oncogene Protein KW - Nuclear Proteins KW - Oncogene Proteins KW - Index Medicus KW - Neuroblastoma -- pathology KW - Mutagenesis, Site-Directed KW - Chromosomes, Human, Pair 1 KW - Neuroblastoma -- genetics KW - Chromosome Deletion KW - Base Sequence KW - Loss of Heterozygosity KW - Humans KW - Reverse Transcriptase Polymerase Chain Reaction KW - Nuclear Proteins -- genetics KW - MicroRNAs -- genetics KW - Oncogene Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69513191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=The+MYCN+oncogene+is+a+direct+target+of+miR-34a.&rft.au=Wei%2C+J+S%3BSong%2C+Y+K%3BDurinck%2C+S%3BChen%2C+Q-R%3BCheuk%2C+A+T+C%3BTsang%2C+P%3BZhang%2C+Q%3BThiele%2C+C+J%3BSlack%2C+A%3BShohet%2C+J%3BKhan%2C+J&rft.aulast=Wei&rft.aufirst=J&rft.date=2008-09-04&rft.volume=27&rft.issue=39&rft.spage=5204&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2008.154 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2007 Jul 26;26(34):5017-22 [17297439] Cancer. 1977 Nov;40(5):2256-63 [922665] Science. 1984 Dec 14;226(4680):1335-7 [6505694] Nature. 1986 Feb 27-Mar 5;319(6056):780-3 [2419762] Proc Natl Acad Sci U S A. 1988 Dec;85(24):9585-9 [3200843] Proc Natl Acad Sci U S A. 1989 May;86(10):3753-7 [2566996] Cell Growth Differ. 1991 May;2(5):245-55 [1679663] Cell. 1992 Apr 3;69(1):119-28 [1555236] Mol Cell Biol. 1993 Sep;13(9):5216-24 [8395000] Cancer Res. 1993 Nov 1;53(21):5269-73 [8221661] Cancer. 1994 Jun 15;73(12):3087-93 [8200007] Nat Genet. 1994 Jul;7(3):370-5 [7920654] Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5520-4 [7777541] Genes Chromosomes Cancer. 1995 Dec;14(4):295-300 [8605118] EMBO J. 1997 Jun 2;16(11):2985-95 [9214616] Eur J Cancer. 1997 Oct;33(12):1991-6 [9516840] Oncol Rep. 1998 Jan-Feb;5(1):267-72 [9458380] Cancer Genet Cytogenet. 1998 Jul 15;104(2):146-52 [9666809] Blood. 1998 Nov 1;92(9):3405-9 [9787180] Oncogene. 1999 May 13;18(19):3004-16 [10378696] Oncogene. 1999 Sep 2;18(35):4948-57 [10490829] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):731-6 [15644444] Gynecol Oncol. 2005 Feb;96(2):510-5 [15661244] Clin Cancer Res. 2005 Feb 1;11(3):1119-28 [15709179] Nature. 2005 Feb 17;433(7027):769-73 [15685193] Oncogene. 2005 Apr 14;24(16):2684-94 [15829979] Cancer Res. 2005 Apr 15;65(8):3136-45 [15833843] Genes Chromosomes Cancer. 2005 Aug;43(4):390-403 [15892104] Nature. 2005 Jun 9;435(7043):834-8 [15944708] Bioinformatics. 2005 Aug 15;21(16):3439-40 [16082012] Cancer Res. 2005 Aug 15;65(16):7065-70 [16103053] Cancer Lett. 2005 Oct 18;228(1-2):29-35 [15907364] Pediatr Blood Cancer. 2008 Feb;50(2):208-12 [17420990] J Clin Oncol. 2000 May;18(9):1888-99 [10784629] Neoplasia. 1999 Apr;1(1):80-9 [10935473] Med Pediatr Oncol. 2000 Dec;35(6):512-5 [11107105] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):31-6 [11134512] Med Pediatr Oncol. 2001 Jan;36(1):32-6 [11464900] Eur J Cancer. 2002 Jan;38(1):92-8 [11750845] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9 [12434020] J Biol Chem. 2003 Jan 31;278(5):2983-9 [12438307] Oncogene. 2003 Feb 20;22(7):1002-11 [12592387] Nat Rev Cancer. 2003 Mar;3(3):203-16 [12612655] Genome Biol. 2003;4(5):P3 [12734009] Plant Physiol. 2003 Jun;132(2):709-17 [12805599] Cell. 2004 Jan 23;116(2):281-97 [14744438] Eur J Cancer. 2004 May;40(8):1255-61 [15110891] Nature. 2004 Sep 16;431(7006):350-5 [15372042] BMC Genomics. 2004 Sep 20;5:70 [15380028] Int J Oncol. 2004 Nov;25(5):1297-302 [15492818] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9 [16166262] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [16199517] N Engl J Med. 2005 Nov 24;353(21):2243-53 [16306521] Oncogene. 2005 Dec 1;24(54):7976-83 [16091745] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19075-80 [16365291] Clin Cancer Res. 2006 Jan 1;12(1):131-8 [16397034] BMC Cancer. 2005;5:161 [16359544] Proc Natl Acad Sci U S A. 2006 May 2;103(18):7024-9 [16641092] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11579-83 [16864777] Biochem Biophys Res Commun. 2006 Dec 8;351(1):192-7 [17055458] Cell. 2007 Feb 9;128(3):459-75 [17289567] Int J Oncol. 2007 May;30(5):1189-96 [17390021] Mol Cell. 2007 Jun 8;26(5):731-43 [17540598] Mol Cell. 2007 Jun 8;26(5):745-52 [17540599] Nature. 2007 Jun 28;447(7148):1130-4 [17554337] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2008.154 ER - TY - JOUR T1 - Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivation. AN - 69513157; 18768696 AB - Microdialysis was used to assess the contribution to cocaine seeking of cholinergic input to the mesocorticolimbic dopamine system in ventral tegmental area (VTA). VTA acetylcholine (ACh) was elevated in animals lever pressing for intravenous cocaine and in cocaine-experienced and cocaine-naive animals passively receiving similar "yoked" injections. In cocaine-trained animals, the elevations comprised an initial (first hour) peak to approximately 160% of baseline and a subsequent plateau of 140% of baseline for the rest of the cocaine intake period. In cocaine-naive animals, yoked cocaine injections raised ACh levels to the 140% plateau but did not cause the initial 160% peak. In cocaine-trained animals that received unexpected saline (extinction conditions) rather than the expected cocaine, the initial peak was seen but the subsequent plateau was absent. VTA ACh levels played a causal role and were not just a correlate of cocaine seeking. Blocking muscarinic input to the VTA increased cocaine intake; the increase in intake offset the decrease in cholinergic input, resulting in the same VTA dopamine levels as were seen in the absence of the ACh antagonists. Increased VTA ACh levels (resulting from 10 microM VTA neostigmine infusion) increased VTA dopamine levels and reinstated cocaine seeking in cocaine-trained animals that had undergone extinction; these effects were strongly attenuated by local infusion of a muscarinic antagonist and weakly attenuated by a nicotinic antagonist. These findings identify two cholinergic responses to cocaine self-administration, an unconditioned response to cocaine itself and a conditioned response triggered by cocaine-predictive cues, and confirm that these cholinergic responses contribute to the control of cocaine seeking. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - You, Zhi-Bing AU - Wang, Bin AU - Zitzman, Dawnya AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. zyou@intra.nida.nih.gov Y1 - 2008/09/03/ PY - 2008 DA - 2008 Sep 03 SP - 9021 EP - 9029 VL - 28 IS - 36 KW - Cholinergic Antagonists KW - 0 KW - Mecamylamine KW - 6EE945D3OK KW - Atropine KW - 7C0697DR9I KW - Cocaine KW - I5Y540LHVR KW - Acetylcholine KW - N9YNS0M02X KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Extinction, Psychological KW - Rats, Long-Evans KW - Substantia Nigra -- drug effects KW - Mecamylamine -- pharmacology KW - Cholinergic Antagonists -- pharmacology KW - Cocaine -- administration & dosage KW - Microdialysis -- methods KW - Substantia Nigra -- metabolism KW - Rats KW - Self Administration -- methods KW - Behavior, Animal -- physiology KW - Atropine -- pharmacology KW - Male KW - Acetylcholine -- metabolism KW - Reward KW - Motivation KW - Conditioning (Psychology) -- physiology KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- physiopathology KW - Dopamine -- metabolism KW - Ventral Tegmental Area -- metabolism KW - Ventral Tegmental Area -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69513157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Acetylcholine+release+in+the+mesocorticolimbic+dopamine+system+during+cocaine+seeking%3A+conditioned+and+unconditioned+contributions+to+reward+and+motivation.&rft.au=You%2C+Zhi-Bing%3BWang%2C+Bin%3BZitzman%2C+Dawnya%3BWise%2C+Roy+A&rft.aulast=You&rft.aufirst=Zhi-Bing&rft.date=2008-09-03&rft.volume=28&rft.issue=36&rft.spage=9021&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.0694-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-16 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1996 Aug 19;730(1-2):133-42 [8883897] Brain Res. 1999 Aug 21;839(1):85-93 [10482802] Nature. 1997 Nov 27;390(6658):401-4 [9389479] J Neurosci. 1998 Jul 1;18(13):5035-44 [9634569] J Comp Neurol. 2005 Mar 7;483(2):217-35 [15678476] J Neurosci. 2000 Feb 15;20(4):1635-42 [10662853] Pharmacol Biochem Behav. 2000 Mar;65(3):375-9 [10683476] J Neurosci. 2000 Oct 1;20(19):7489-95 [11007908] Eur J Neurosci. 2000 Oct;12(10):3596-604 [11029630] J Neurosci. 2001 Mar 1;21(5):1452-63 [11222635] J Neurosci. 2001 Aug 1;21(15):5841-6 [11466456] Neuroscience. 2001;106(3):633-41 [11591463] J Neurosci. 2002 Jan 1;22(1):RC190 [11756520] J Neurosci. 2002 Jul 15;22(14):6247-53 [12122083] Eur J Pharmacol. 2003 Sep 5;477(1):37-44 [14512096] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Psychopharmacology (Berl). 2004 Aug;175(1):53-9 [14767633] J Pharmacol Exp Ther. 1968 May;161(1):122-9 [5648489] J Comp Physiol Psychol. 1969 May;68(1):22-30 [5798120] Psychopharmacologia. 1974 Jan 14;34(3):255-64 [4819978] Biochem Pharmacol. 1975 Apr 15;24(8):847-52 [1125084] Nature. 1976 Mar 18;260(5548):258-60 [1256567] Can J Psychol. 1977 Dec;31(4):195-203 [608135] Brain Res. 1980 Mar 3;185(1):1-15 [7353169] Brain Res. 1981 May 25;213(1):190-4 [7016258] Science. 1983 Aug 19;221(4612):773-5 [6879176] Brain Res. 1985 Mar 11;329(1-2):19-26 [3872153] Brain Res. 1985 Dec 2;348(2):355-8 [4075093] Neurosci Lett. 1986 May 23;66(3):281-6 [2425289] Brain Res Bull. 1986 May;16(5):603-37 [3742247] Neuroscience. 1986 Oct;19(2):551-64 [3774154] Acta Physiol Scand. 1986 Nov;128(3):351-8 [3788613] Eur J Pharmacol. 1987 Sep 23;141(3):395-9 [3666033] J Neurosci. 1988 Jan;8(1):100-12 [3339402] Neuroscience. 1989;28(3):611-23 [2710334] Pharmacol Biochem Behav. 1989 Feb;32(2):527-31 [2727015] Pharmacol Biochem Behav. 1988 Nov;31(3):547-59 [3251239] J Comp Neurol. 1989 Jun 8;284(2):314-35 [2754038] J Neurosci. 1989 Oct;9(10):3400-9 [2795130] Pharmacol Biochem Behav. 1989 Dec;34(4):899-904 [2623043] J Neurosci. 1990 Aug;10(8):2541-59 [2388079] Neurosci Lett. 1990 Jul 3;114(2):154-9 [2395528] Synapse. 1990;6(1):106-12 [1697988] Proc Natl Acad Sci U S A. 1990 Sep;87(18):7050-4 [2402490] Brain Res. 1990 Aug 27;526(1):45-53 [2078817] Neuroscience. 1991;41(2-3):483-94 [1678502] Synapse. 1994 Jan;16(1):36-44 [8134899] Pharmacol Toxicol. 1994 Dec;75(6):348-52 [7534921] J Neurosci. 1995 Sep;15(9):5859-69 [7666171] Psychopharmacology (Berl). 1995 Jul;120(1):10-20 [7480530] J Neurosci. 1996 Jan 15;16(2):714-22 [8551354] J Comp Neurol. 1995 Dec 11;363(2):177-96 [8642069] Psychopharmacology (Berl). 1995 Nov;122(2):194-7 [8848536] J Comp Neurol. 1996 Jan 8;364(2):254-66 [8788248] J Neurosci. 2005 May 11;25(19):4725-32 [15888648] J Comp Neurol. 2006 Feb 20;494(6):863-75 [16385486] Brain Res. 2006 Oct 20;1116(1):143-52 [16942754] J Neurosci. 2007 May 23;27(21):5730-43 [17522317] J Neurosci. 2007 Sep 26;27(39):10546-55 [17898226] Neuroreport. 2008 Jun 11;19(9):991-5 [18521007] Synapse. 1999 Mar 15;31(4):241-9 [10051104] Pharmacol Biochem Behav. 1997 Aug;57(4):915-21 [9259024] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.0694-08.2008 ER - TY - JOUR T1 - Obesity and addiction: common neurological mechanisms and drug development. AN - 69461010; 18571681 JF - Physiology & behavior AU - Rapaka, Rao AU - Schnur, Paul AU - Shurtleff, David AD - National Institute on Drug Abuse, National Institutes of Health, United States. Y1 - 2008/09/03/ PY - 2008 DA - 2008 Sep 03 SP - 2 EP - 9 VL - 95 IS - 1-2 SN - 0031-9384, 0031-9384 KW - Index Medicus KW - Animals KW - Humans KW - Substance-Related Disorders -- physiopathology KW - Obesity -- drug therapy KW - Obesity -- pathology KW - Substance-Related Disorders -- pathology KW - Substance-Related Disorders -- drug therapy KW - Obesity -- physiopathology KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69461010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiology+%26+behavior&rft.atitle=Obesity+and+addiction%3A+common+neurological+mechanisms+and+drug+development.&rft.au=Rapaka%2C+Rao%3BSchnur%2C+Paul%3BShurtleff%2C+David&rft.aulast=Rapaka&rft.aufirst=Rao&rft.date=2008-09-03&rft.volume=95&rft.issue=1-2&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Physiology+%26+behavior&rft.issn=00319384&rft_id=info:doi/10.1016%2Fj.physbeh.2008.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-18 N1 - Date created - 2008-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.physbeh.2008.05.001 ER - TY - JOUR T1 - Follicular dendritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin. AN - 69613443; 18761751 AB - Follicular dendritic cell (FDC) sarcoma is a rare neoplasm arising in lymph nodes but also in extranodal sites from accessory cells of the immune system that are essential for the function of antigen presentation and germinal center reaction regulation. FDC sarcoma has a significant recurrent and metastatic potential and for these reason it should be viewed as an intermediate grade malignancy. We report the case of a 49-year old woman patient who showed persistent, enlarged, hard, cervical lymph node. The most common histologic feature was the presence of oval to spindle cells with elongated nuclei, vesicular or stippled chromatin and scant eosinophilic cytoplasm. Immunohistochemically, tumor cells were diffusely positive for follicular dendritic cell markers CD21, CD23 and negative for cytokeratin.The patient after complete excision of the lymph node underwent five courses of adjuvant chemotherapy with COP plus PEG-liposomal doxorubicin, considering the propensity of the tumor to metastasize. No hematological or cardiac toxicity were registered and among the other extra hematological effects only transitory palmar erythrodysesthesia is worthy of mention. After a follow up of 5 years the patient is alive and in CR. These results suggest that this therapeutic modality may be useful in the management of FDC sarcoma. JF - Journal of experimental & clinical cancer research : CR AU - Pisani, Francesco AU - Marino, Mirella AU - Sentinelli, Steno AU - Petti, Maria Concetta AD - Department of Hematology, Regina Elena National Cancer Institute, Rome, Italy. fr.pisani@tiscali.it Y1 - 2008/09/02/ PY - 2008 DA - 2008 Sep 02 SP - 33 VL - 27 KW - Antibiotics, Antineoplastic KW - 0 KW - Receptors, Complement 3d KW - Receptors, IgE KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Humans KW - Receptors, Complement 3d -- immunology KW - Receptors, IgE -- immunology KW - Lymph Nodes -- pathology KW - Middle Aged KW - Female KW - Chemotherapy, Adjuvant KW - Dendritic Cell Sarcoma, Follicular -- surgery KW - Head and Neck Neoplasms -- therapy KW - Dendritic Cell Sarcoma, Follicular -- therapy KW - Doxorubicin -- therapeutic use KW - Head and Neck Neoplasms -- surgery KW - Head and Neck Neoplasms -- drug therapy KW - Dendritic Cell Sarcoma, Follicular -- drug therapy KW - Antibiotics, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69613443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.atitle=Follicular+dendritic+cell+sarcoma+of+the+neck%3A+report+of+a+case+treated+by+surgical+excision+and+COP+plus+%28PEG%29-liposomal+doxorubicin.&rft.au=Pisani%2C+Francesco%3BMarino%2C+Mirella%3BSentinelli%2C+Steno%3BPetti%2C+Maria+Concetta&rft.aulast=Pisani&rft.aufirst=Francesco&rft.date=2008-09-02&rft.volume=27&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.issn=1756-9966&rft_id=info:doi/10.1186%2F1756-9966-27-33 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-12 N1 - Date created - 2008-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 1986 Mar;122(3):562-72 [2420185] Tumori. 2003 May-Jun;89(3):237-49 [12908776] Semin Diagn Pathol. 1998 May;15(2):144-54 [9606805] Am J Hematol. 1998 Oct;59(2):161-7 [9766802] J Pak Med Assoc. 2006 Mar;56(3):137-9 [16696516] Virchows Arch. 2006 Aug;449(2):148-58 [16758173] Int J Clin Oncol. 2007 Feb;12(1):56-8 [17380443] J Clin Oncol. 1999 Jul;17(7):2290-2 [10561286] Histopathology. 2001 Jun;38(6):510-8 [11422494] Mod Pathol. 2002 Jan;15(1):50-8 [11796841] Histopathology. 2002 Jul;41(1):1-29 [12121233] Drugs. 2002;62(14):2089-126 [12269857] Auris Nasus Larynx. 2002 Oct;29(4):401-3 [12393051] Oral Oncol. 2003 Jun;39(4):415-9 [12676264] Clin Pharmacokinet. 2003;42(5):419-36 [12739982] Cancer. 1997 Jan 15;79(2):294-313 [9010103] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1756-9966-27-33 ER - TY - JOUR T1 - Replica exchange simulations of transient encounter complexes in protein-protein association AN - 20775378; 10315286 AB - Recent paramagnetic relaxation enhancement (PRE) studies on several weakly interacting protein complexes have unequivocally demonstrated the existence of transient encounter complexes. Here, we present a computational method to study protein-protein binding by creating equilibrium ensembles that include both specific and nonspecific protein complexes. In a joint analysis of simulation and experiment we explore the physical nature and underlying physicochemical characteristics of encounter complexes involving three protein-protein interactions of the bacterial phosphotransferase system. Replica exchange Monte Carlo simulations using a coarse-grained energy function recover the structures of the specific complexes and produce binding affinities in good agreement with experiment. Together with the specific complex, a relatively small number of distinct nonspecific complexes largely accounts for the measured PRE data. The combined relative population of the latter is less than a1/410%. The binding interfaces of the specific and nonspecific complexes differ primarily in size but exhibit similar amino acid compositions. We find that the overall funnel-shaped energy landscape of complex formation is dominated by the specific complex, a small number of structured nonspecific complexes, and a diffuse cloud of loosely bound complexes connecting the specific and nonspecific binding sites with each other and the unbound state. Nonspecific complexes may not only accelerate the binding kinetics by enhancing the rate of success of random diffusional encounters but also play a role in protein function as alternative binding modes. JF - Proceedings of the National Academy of Sciences, USA AU - Kim, Young C AU - Tang, Chun AU - Clore, GMarius AU - Hummer, Gerhard Y1 - 2008/09/02/ PY - 2008 DA - 2008 Sep 02 SP - 12855 EP - 12860 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 35 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Sustainability Science Abstracts KW - protein binding KW - transient nonspecific encounter complexes KW - paramagnetic relaxation enhancement KW - bacterial phosphotransferase system KW - Monte Carlo simulation KW - Amino acids KW - Data processing KW - Physicochemical properties KW - Landscape KW - Simulation KW - Amino acid composition KW - phosphotransferase KW - Computer applications KW - Clouds KW - Structure-function relationships KW - Energy KW - Kinetics KW - Proteins KW - Protein interaction KW - M3 1010:Issues in Sustainable Development KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20775378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Replica+exchange+simulations+of+transient+encounter+complexes+in+protein-protein+association&rft.au=Kim%2C+Young+C%3BTang%2C+Chun%3BClore%2C+GMarius%3BHummer%2C+Gerhard&rft.aulast=Kim&rft.aufirst=Young&rft.date=2008-09-02&rft.volume=105&rft.issue=35&rft.spage=12855&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0802460105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Clouds; Data processing; Structure-function relationships; Kinetics; Energy; Amino acid composition; phosphotransferase; Computer applications; Protein interaction; Amino acids; Landscape; Physicochemical properties; Simulation; Proteins DO - http://dx.doi.org/10.1073/pnas.0802460105 ER - TY - JOUR T1 - Body size and the risk of biliary tract cancer: a population-based study in China AN - 19618231; 8613125 AB - Though obesity is an established risk factor for gall bladder cancer, its role in cancers of the extrahepatic bile ducts and ampulla of Vater is less clear, as also is the role of abdominal obesity. In a population-based case-control study of biliary tract cancer in Shanghai, China, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for biliary tract cancer in relation to anthropometric measures, including body mass index (BMI) at various ages and waist-to-hip ratio (WHR), adjusting for age, sex, and education. The study included 627 patients with biliary tract cancer (368 gall bladder, 191 bile duct, 68 ampulla of Vater) and 959 healthy subjects randomly selected from the population. A higher BMI at all ages, including early adulthood (ages 20-29 years), and a greater WHR were associated with an increased risk of gall bladder cancer. A high usual adult BMI ( greater than or equal to 25) was associated with a 1.6-fold risk of gall bladder cancer (95% Cl 1.2-2.1, P for trend 0.90) having the highest risk of gall bladder cancer (OR = 12.6, 95% Cl 4.8-33.2), relative to those with a low BMI and WHR We found no clear risk patterns for cancers of the bile duct and ampulla of Vater. These results suggest that both overall and abdominal obesity, including obesity in early adulthood, are associated with an increased risk of gall bladder cancer. The increasing prevalence of obesity and cholesterol stones in Shanghai seems at least partly responsible for the rising incidence of gall bladder cancer in Shanghai. JF - British Journal of Cancer AU - Hsing, A W AU - Sakoda, L C AU - Rashid, A AU - Chen, J AU - Shen, M C AU - Han, T Q AU - Wang, B S AU - Gao, Y T AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 5024, Bethesda, MD 20892-7324, USA, hsinga@mail.nih.gov Y1 - 2008/09/02/ PY - 2008 DA - 2008 Sep 02 SP - 811 EP - 815 VL - 99 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Age KW - obesity KW - body size KW - cholesterol KW - Cancer KW - urinary bladder KW - Education KW - body mass KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19618231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Body+size+and+the+risk+of+biliary+tract+cancer%3A+a+population-based+study+in+China&rft.au=Hsing%2C+A+W%3BSakoda%2C+L+C%3BRashid%2C+A%3BChen%2C+J%3BShen%2C+M+C%3BHan%2C+T+Q%3BWang%2C+B+S%3BGao%2C+Y+T&rft.aulast=Hsing&rft.aufirst=A&rft.date=2008-09-02&rft.volume=99&rft.issue=5&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604616 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - China, People's Rep., Shanghai; China, People's Rep.; Cancer; urinary bladder; obesity; Age; cholesterol; Education; body mass; body size DO - http://dx.doi.org/10.1038/sj.bjc.6604616 ER - TY - JOUR T1 - Effect of the cochlear microphonic on the limiting frequency of the mammalian ear. AN - 742776438; pmid-19045652 AB - Electromotility is a basis for cochlear amplifier, which controls the sensitivity of the mammalian ear and contributes to its frequency selectivity. Because it is driven by the receptor potential, its frequency characteristics are determined by the low-pass RC filter intrinsic to the cell, which has a corner frequency about 1/10th of the operating frequency. This filter significantly decreases the efficiency of electromotility as an amplifier. The present paper examines a proposal that the cochlear microphonic, the voltage drop across the extracellular medium by the receptor current, contributes to overcome this problem. It is found that this effect can improve frequency dependence. However, this effect alone is too small to enhance the effectiveness of electromotility beyond 10 kHz in the mammalian ear. JF - The Journal of the Acoustical Society of America AU - Iwasa, Kuni H AU - Sul, Bora AD - Section on Biophysics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Ct Rm 1B03, Rockville, Maryland 20850-3211, USA. ki2s@nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1607 EP - 1612 VL - 124 IS - 3 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Hair Cells, Auditory, Outer -- physiology KW - Animals KW - Endolymph -- physiology KW - Viscosity KW - Auditory Threshold KW - Humans KW - Perilymph -- physiology KW - Acoustic Stimulation KW - Basilar Membrane -- physiology KW - Time Factors KW - Models, Biological KW - Mechanotransduction, Cellular KW - Cochlea -- physiology KW - Cochlear Microphonic Potentials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742776438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Effect+of+the+cochlear+microphonic+on+the+limiting+frequency+of+the+mammalian+ear.&rft.au=Iwasa%2C+Kuni+H%3BSul%2C+Bora&rft.aulast=Iwasa&rft.aufirst=Kuni&rft.date=2008-09-01&rft.volume=124&rft.issue=3&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - SuppNotes - Cites: Curr Biol. 2007 Aug 7;17(15):1340-4[17658260]; Cites: J Acoust Soc Am. 2003 Jan;113(1):453-61[12558282]; Cites: ORL J Otorhinolaryngol Relat Spec. 2006;68(6):373-7[17065832]; Cites: J Neurosci. 2006 Apr 12;26(15):3992-8[16611815]; Cites: J Neurosci. 2004 Nov 10;24(45):10057-63[15537874]; Cites: Biophys J. 2003 Feb;84(2 Pt 1):739-49[12547758]; Cites: Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17101-6[12461165]; Cites: Nature. 2002 Sep 19;419(6904):300-4[12239568]; Cites: Physiol Rev. 2001 Jul;81(3):1305-52[11427697]; Cites: Neuron. 2008 May 8;58(3):333-9[18466744]; Cites: J Physiol. 1996 Nov 1;496 ( Pt 3):639-46[8930832]; Cites: Biophys J. 1997 Jul;73(1):546-55[9199816]; Cites: Science. 1995 Jun 9;268(5216):1420-1[7770765]; Cites: Science. 1995 Mar 31;267(5206):2006-9[7701325]; Cites: J Physiol. 1992 Mar;448:73-98[1593487]; Cites: J Neurosci. 1992 May;12(5):1906-16[1578277]; Cites: J Physiol. 1987 Feb;383:551-69[3656135]; Cites: Hear Res. 1990 Mar;44(2-3):241-56[2329097]; Cites: J Acoust Soc Am. 1980 Dec;68(6):1660-70[7462465]; Cites: J Acoust Soc Am. 1976 Aug;60(2):510-2[993471]; Cites: J Acoust Soc Am. 1971 Apr;49(4):Suppl 2:1218+[4994693]; Cites: Nature. 2004 Jun 17;429(6993):766-70[15201911]; Cites: J Physiol. 2003 Mar 15;547(Pt 3):873-91[12562920]; Cites: J Acoust Soc Am. 2007 May;121(5 Pt1):2758-73[17550176] N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Familial and genetic risk of transitional cell carcinoma of the urinary tract. AN - 69528896; 18562223 AB - Environmental exposures, including tobacco smoke and occupational exposure to aromatic amines, have been implicated in bladder cancer etiology. However, the pathogenesis of urinary bladder transitional cell carcinoma remains incompletely defined. In epidemiologic studies, family history confers a 2-fold increase in bladder cancer risk, but it is uncertain whether this represents evidence of a genetic and/or a shared environmental basis for familial aggregation. Polymorphisms in genes involved in the metabolism of environmental toxins (e.g., NAT2) clearly modify individual susceptibility to bladder cancer. A genetic predisposition has also been suggested by case reports describing multiple-case families, and the development of bladder cancer in association with several well-described Mendelian disorders (e.g., HNPCC, retinoblastoma). Here we update a previously reported family, report a new multiple-case kindred, critically review previously reported bladder cancer families, and the epidemiologic literature related to family history of transitional cell carcinoma of the urinary tract (TCCUT) as a risk factor, as well as provide a brief summary of genetic factors that have been implicated in TCCUT risk. We conclude that familial TCCUT is either very uncommon or significantly under-reported, perhaps on the assumption that this is an environmental rather than a genetic disorder. The interaction between multiple genetic and environmental factors has made it challenging to identify genetic components responsible for many common diseases; therefore, a proposed genome-wide association study (GWAS) for urinary bladder cancer may help to clarify the etiologic role of the candidate genetic pathways reviewed here, as well as characterize gene/environment interactions that contribute to TCCUT carcinogenesis. JF - Urologic oncology AU - Mueller, Christine M AU - Caporaso, Neil AU - Greene, Mark H AD - Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, Rockville, MD 20852, USA. muellerc@mail.nih.gov PY - 2008 SP - 451 EP - 464 VL - 26 IS - 5 SN - 1078-1439, 1078-1439 KW - Index Medicus KW - Pedigree KW - Humans KW - Urinary Bladder Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Carcinoma, Transitional Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69528896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urologic+oncology&rft.atitle=Familial+and+genetic+risk+of+transitional+cell+carcinoma+of+the+urinary+tract.&rft.au=Mueller%2C+Christine+M%3BCaporaso%2C+Neil%3BGreene%2C+Mark+H&rft.aulast=Mueller&rft.aufirst=Christine&rft.date=2008-09-01&rft.volume=26&rft.issue=5&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Urologic+oncology&rft.issn=10781439&rft_id=info:doi/10.1016%2Fj.urolonc.2008.02.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-04 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Urol. 1993 Aug;72(2):177-80 [8402022] Eur J Cancer. 1993;29A(16):2335-6 [8110507] J Natl Cancer Inst. 1994 Nov 2;86(21):1600-8 [7932824] Med Pediatr Oncol. 1995 Apr;24(4):269-70 [7700174] J Am Acad Dermatol. 1995 Nov;33(5 Pt 2):909-12 [7593809] Pharmacogenetics. 1995;5 Spec No:S97-102 [7581498] J Urol. 1996 Mar;155(3):1035-6 [8583556] Int J Cancer. 1996 Aug 7;67(4):515-9 [8759610] J Urol. 1997 May;157(5):1649-51 [9112497] J Urol. 1998 Aug;160(2):466-70 [9679899] J Cell Biochem. 2005 May 1;95(1):24-33 [15759278] Int J Cancer. 2005 Aug 20;116(2):282-4 [15800923] Carcinogenesis. 2005 Jul;26(7):1263-71 [15746160] Am J Med Genet C Semin Med Genet. 2005 Aug 15;137C(1):72-7 [16010679] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Nat Rev Cancer. 2005 Sep;5(9):713-25 [16110317] Int J Cancer. 2007 Dec 15;121(12):2748-52 [17724720] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] Pharmacogenetics. 2000 Feb;10(1):5-10 [10739167] Cancer. 2000 Aug 1;89(3):630-9 [10931463] Int J Cancer. 2000 Nov 1;88(3):493-6 [11054683] Urology. 2001 Feb;57(2):266-9 [11182334] J Urol. 2001 Dec;166(6):2129-33 [11696721] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1239-48 [11751440] Int J Cancer. 2002 Mar 10;98(2):274-8 [11857419] Am J Med Genet C Semin Med Genet. 2003 Feb 15;117C(1):42-8 [12561057] BJU Int. 2003 Feb;91(3):297 [12581024] J Urol. 1981 Nov;126(5):691-2 [7053069] Clin Pharmacol Ther. 1983 May;33(5):591-602 [6687705] J Urol. 1983 Oct;130(4):772-3 [6887416] Br J Clin Pharmacol. 1984 Apr;17(4):459-64 [6721992] Carcinogenesis. 1984 Sep;5(9):1191-2 [6467507] Ophthalmologica. 1984;189(3):143-6 [6493695] Nature. 1984 Nov 8-14;312(5990):169-70 [6504125] Int J Cancer. 1985 Jun 15;35(6):703-6 [4008097] Urology. 1986 May;27(5):394-6 [3705270] Am J Epidemiol. 1986 Jun;123(6):1033-42 [3706274] J Natl Cancer Inst. 2003 Apr 2;95(7):540-7 [12671022] J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8 [12928346] Nat Rev Cancer. 2003 Oct;3(10):733-44 [14570033] Birth Defects Res C Embryo Today. 2003 Nov;69(4):286-304 [14745970] Nat Rev Cancer. 2004 Feb;4(2):153-8 [14964310] J Natl Cancer Inst. 2004 Feb 18;96(4):261-8 [14970275] J Natl Cancer Inst. 2004 Mar 3;96(5):357-63 [14996857] Nat Med. 2004 Apr;10(4):374-81 [15034568] Am J Clin Oncol. 2004 Aug;27(4):411-9 [15289737] Ann Rheum Dis. 2004 Oct;63(10):1307-11 [15130900] J Urol. 1966 Nov;96(5):697-701 [5923294] J Natl Cancer Inst. 1973 Jul;51(1):269-70 [4720876] J Urol. 1975 May;113(5):629-35 [1127804] Trans Ophthalmol Soc U K. 1974;94(4):938-44 [4534143] J Natl Cancer Inst. 1976 Jun;56(6):1101-4 [994212] Med Pediatr Oncol. 1976;2(4):379-85 [1004381] Br J Urol. 1976 Dec;48(6):442 [1009327] J Natl Cancer Inst. 1977 Feb;58(2):205-7 [264592] J Urol. 1979 Oct;122(4):458-61 [480484] Semin Oncol. 1979 Jun;6(2):254-6 [482963] Environ Health Perspect. 1979 Apr;29:71-9 [510245] Br Med J. 1979 Sep 29;2(6193):798 [519209] Br J Cancer. 1986 May;53(5):661-71 [3718823] Am J Med Genet. 1986 Nov;25(3):473-6 [3789010] Cancer Genet Cytogenet. 1987 Jul;27(1):161-5 [3581037] Cancer Res. 1987 Oct 15;47(20):5488-93 [3652049] Int J Cancer. 1988 Apr 15;41(4):499-504 [3356485] Br J Cancer. 1989 Sep;60(3):358-65 [2789942] J Urol. 1990 Jan;143(1):24-8 [2294255] Cancer. 1991 Jul 1;68(1):206-10 [2049747] Epidemiology. 1991 Mar;2(2):145-8 [1932313] Cancer. 1992 Apr 1;69(7):1776-90 [1551063] Carcinogenesis. 1992 Jun;13(6):1035-8 [1600608] Nat Genet. 2005 Oct;37(10):1038-40 [16170316] Psychosomatics. 2006 Jan-Feb;47(1):75-85 [16384813] Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):180-3 [16434610] Am J Hum Genet. 2006 Mar;78(3):464-79 [16465622] Eur J Hum Genet. 2006 Apr;14(4):390-402 [16479259] Eur J Cancer. 2006 Jul;42(10):1428-33 [16737809] Am J Med Genet A. 2006 Oct 15;140(20):2245-7 [16969861] Cancer. 2006 Aug 15;107(4):705-11 [16845665] Australas J Dermatol. 2006 Nov;47(4):266-9 [17034469] Am J Hum Genet. 2007 Jan;80(1):126-39 [17160900] South Med J. 2006 Nov;99(11):1256-63 [17195421] Oncologist. 2007 Jan;12(1):20-37 [17227898] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9 [17416776] Cancer Causes Control. 2007 Jun;18(5):479-84 [17440825] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1595-600 [17684133] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.urolonc.2008.02.016 ER - TY - JOUR T1 - Characterization of uterine granular cell tumors in B6C3F1 mice: a histomorphologic, immunohistochemical, and ultrastructural study. AN - 69465489; 18725470 AB - The granular cell tumor is most often a benign neoplasm of uncertain origin. Four uterine granular cell tumors in control and treated female B6C3F1 mice were identified in chronic studies at the National Toxicology Program. Two tumors occurred in untreated control animals and 2 in treated animals receiving different compounds. Tissue sections were evaluated histologically and stained with hematoxylin and eosin, periodic acid-Schiff with diastase resistance, Masson's trichrome, toluidine blue, phosphotungstic acid-hematoxylin, and stained immunohistochemically with a panel of antibodies to muscle (desmin, alpha smooth muscle actin), neural (S-100, neuron specific enolase), epithelial (wide-spectrum cytokeratin), and macrophage (F4/80) markers. The main histomorphologic feature of tumor cells was the presence of abundant cytoplasmic eosinophilic granules that stained positive for periodic acid-Schiff with diastase resistance. Tumors varied in appearance and were comprised of sheets and nests of round to polygonal cells with distinct borders. Nuclei were hyperchromatic, pleomorphic, and centrally to eccentrically located and often contained single nucleoli. Occasional multinucleated giant cells were observed. Tumors were pale pink and homogeneous with trichrome stain and negative with toluidine blue. Three tumors had positive to weakly positive immunoreactivity for desmin, and 1 was positive for alpha smooth muscle actin. Expression of S-100, wide-spectrum cytokeratin, and neuron-specific enolase was negative for all tumors. Ultrastructurally, prominent electron-dense cytoplasmic granules were abundant and contained secondary lysosomes with heterogeneous lysosomal contents. The characteristics of these uterine granular cell tumors were suggestive of a myogenic origin. JF - Veterinary pathology AU - Veit, A C AU - Painter, J T AU - Miller, R A AU - Hardisty, J F AU - Dixon, D AD - Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD C2-09, 111 T.W. Alexander Drive, Bldg. 101, Research Triangle Park, NC 27709 (USA). Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 654 EP - 662 VL - 45 IS - 5 SN - 0300-9858, 0300-9858 KW - Index Medicus KW - Animals KW - Microscopy, Electron -- veterinary KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Crosses, Genetic KW - Mice KW - Immunohistochemistry -- veterinary KW - Animals, Laboratory KW - Female KW - Uterine Neoplasms -- ultrastructure KW - Granular Cell Tumor -- ultrastructure KW - Granular Cell Tumor -- metabolism KW - Uterine Neoplasms -- veterinary KW - Uterine Neoplasms -- metabolism KW - Granular Cell Tumor -- veterinary KW - Granular Cell Tumor -- pathology KW - Uterine Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69465489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+pathology&rft.atitle=Characterization+of+uterine+granular+cell+tumors+in+B6C3F1+mice%3A+a+histomorphologic%2C+immunohistochemical%2C+and+ultrastructural+study.&rft.au=Veit%2C+A+C%3BPainter%2C+J+T%3BMiller%2C+R+A%3BHardisty%2C+J+F%3BDixon%2C+D&rft.aulast=Veit&rft.aufirst=A&rft.date=2008-09-01&rft.volume=45&rft.issue=5&rft.spage=654&rft.isbn=&rft.btitle=&rft.title=Veterinary+pathology&rft.issn=03009858&rft_id=info:doi/10.1354%2Fvp.45-5-654 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pathol. 1984 Mar;142(3):221-9 [6323661] Cancer. 1984 May 15;53(10):2104-10 [6704900] Virchows Arch A Pathol Anat Histopathol. 1985;406(1):1-5 [2581359] J Comp Pathol. 1985 Apr;95(2):175-92 [3915749] Vet Pathol. 1987 Jan;24(1):50-8 [3824823] Vet Pathol. 1987 May;24(3):273-6 [3603967] Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;53(1):52-7 [2885972] Oral Surg Oral Med Oral Pathol. 1988 Apr;65(4):427-35 [2834681] J Comp Pathol. 1988 May;98(4):481-7 [3417916] Vet Pathol. 1984 Sep;21(5):489-94 [6091314] J Comp Pathol. 1989 Jul;101(1):109-12 [2794147] Crit Rev Toxicol. 1990;20(4):287-310 [2178628] Lab Anim. 1991 Oct;25(4):299-302 [1753688] Vet Pathol. 1992 Jan;29(1):86-9 [1557868] Vet Pathol. 1993 Mar;30(2):176-85 [8470338] Ultrastruct Pathol. 1993 May-Aug;17(3-4):271-8 [8266592] Toxicol Pathol. 1997 Mar-Apr;25(2):211-6 [9125780] Toxicol Pathol. 1997 Jul-Aug;25(4):409 [9280127] Adv Anat Pathol. 1999 Jul;6(4):186-203 [10410172] Arch Pathol Lab Med. 1999 Oct;123(10):967-73 [10506457] J Natl Cancer Inst. 1961 Sep;27:611-53 [13726967] J Natl Cancer Inst. 1963 Aug;31:425-55 [14046632] Vet Rec. 2006 Feb 4;158(5):168-70 [16461626] Vet Pathol. 2000 Sep;37(5):439-48 [11055867] J Vet Med Sci. 2001 Apr;63(4):449-52 [11346182] Vet Pathol. 2001 May;38(3):332-6 [11355666] Vet Pathol. 2001 Nov;38(6):620-7 [11732794] J Vet Med Sci. 2004 Jan;66(1):77-9 [14960817] Vet Clin Pathol. 2004;33(2):111-4 [15195271] Arch Pathol Lab Med. 2004 Jul;128(7):771-5 [15214825] Am J Vet Res. 1968 Jun;29(6):1309-13 [4297859] J Pathol. 1973 Feb;109(2):101-11 [4124410] Pathol Annu. 1974;9(0):43-79 [4371717] Cornell Vet. 1978 Oct;68(4):506-20 [213238] J Oral Surg. 1979 Jun;37(6):402-6 [220399] J Comp Pathol. 1979 Jul;89(3):421-30 [231057] Histopathology. 1981 Jan;5(1):69-79 [7194305] J Environ Pathol Toxicol. 1980 Nov;4(5-6):81-95 [7217862] J Comp Pathol. 1981 Oct;91(4):471-81 [6274928] Vet Pathol. 1982 Jan;19(1):23-9 [7072082] Diagn Histopathol. 1982 Jul-Sep;5(3):205-11 [6183084] J Oral Pathol. 1982;11(5):343-52 [6183416] Vet Q. 1983;5(2):89-93 [6308883] Am J Pathol. 1983 Aug;112(2):139-46 [6192721] Virchows Arch A Pathol Anat Histopathol. 1983;402(1):35-45 [6318425] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1354/vp.45-5-654 ER - TY - JOUR T1 - Depressive Symptoms and Interpersonal Victimization Among African American Women Attending an Urban STD Clinic AN - 61780154; 200901792 AB - Objectives: This study evaluated the association of depressive symptom levels & interpersonal victimization. The sample was comprised of 455 African American women attending an urban sexually transmitted disease clinic. Interpersonal victimization was defined as whether a woman was forced to have sexual intercourse & whether a woman was ever hit, slap or physically hurt by a boyfriend, girlfriend, or spouse in the past 12 months. Methods: Using audio computer-assisted self-interviewing (ACASI), women responded to questions regarding interpersonal victimization & depressive symptom levels (e.g., depression, sadness, loneliness & crying in the past week). Results: Results indicated that women with a history of interpersonal victimization were more likely to experience higher levels of depressive symptoms when compared with women who did not. Statistically significant differences were found for being forced to have sexual intercourse (all p's <0.0001) & ever being hit, slap or physically hurt by a boyfriend, girlfriend, or spouse in the past 12 months (p's range from 0.012 to 0.0003) with regard to each depressive symptom item. Conclusion: Behavioral women-focused interventions need to address mental health issues associated with risky sexual behaviors in order to be more efficacious. [Copyright 2008 Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Williams, Makeda J AU - Grimley, Diane M AD - National Cancer Institute, Bethesda, Maryland Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 375 EP - 380 PB - Elsevier Science, New York NY VL - 18 IS - 5 SN - 1049-3867, 1049-3867 KW - Loneliness KW - Sexual Behavior KW - Black Americans KW - Depression (Psychology) KW - Womens History KW - Victims KW - Sexual Intercourse KW - Victimization KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61780154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Depressive+Symptoms+and+Interpersonal+Victimization+Among+African+American+Women+Attending+an+Urban+STD+Clinic&rft.au=Williams%2C+Makeda+J%3BGrimley%2C+Diane+M&rft.aulast=Williams&rft.aufirst=Makeda&rft.date=2008-09-01&rft.volume=18&rft.issue=5&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2008.06.004 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-01-08 N1 - Number of references - 27 N1 - Last updated - 2016-09-28 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - Depression (Psychology); Victims; Victimization; Sexual Intercourse; Black Americans; Loneliness; Sexual Behavior; Womens History DO - http://dx.doi.org/10.1016/j.whi.2008.06.004 ER - TY - JOUR T1 - Noninvasive Assessment of Glycosaminoglycan Production in Injectable Tissue-Engineered Cartilage Constructs Using Magnetic Resonance Imaging AN - 21061511; 8552534 AB - The glycosaminoglycan (GAG) content of engineered cartilage is a determinant of biochemical and mechanical quality. The ability to measure the degree to which GAG content is maintained or increases in an implant is therefore of importance in cartilage repair procedures. The gadolinium exclusion magnetic resonance imaging (MRI) method for estimating matrix fixed charge density (FCD) is ideally suited to this. One promising approach to cartilage repair is use of seeded injectable hydrogels. Accordingly, we assess the reliability of measuring GAG content in such a system ex vivo using MRI. Samples of the photo-polymerizable hydrogel, poly(ethylene oxide) diacrylate, were seeded with bovine chondrocytes ( similar to 2.4 million cells/sample). The FCD of the constructs was determined using MRI after 9, 16, 29, 36, 43, and 50 days of incubation. Values were correlated with the results of biochemical determination of GAG from the same samples. FCD and GAG were found to be statistically significantly correlated (R super(2) = 0.91, p < 0.01). We conclude that MRI-derived FCD measurements of FCD in injectable hydrogels reflect tissue GAG content and that this methodology therefore has potential for in vivo monitoring of such constructs. JF - Tissue Engineering, Part C: Methods AU - Ramaswamy, S AU - Uluer, M C AU - Leen, S AU - Bajaj, P AU - Fishbein, K W AU - Spencer, R G AD - Magnetic Resonance Imaging and Spectroscopy Section, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Room 4D-08, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA, spencer@helix.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 243 EP - 250 VL - 14 IS - 3 SN - 1937-3384, 1937-3384 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Glycosaminoglycans KW - hydrogels KW - Cartilage KW - Magnetic resonance imaging KW - Gadolinium KW - Computed tomography KW - Chondrocytes KW - oxides KW - Tissue engineering KW - Mechanical properties KW - T 2030:Cartilage and Cartilage Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21061511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+C%3A+Methods&rft.atitle=Noninvasive+Assessment+of+Glycosaminoglycan+Production+in+Injectable+Tissue-Engineered+Cartilage+Constructs+Using+Magnetic+Resonance+Imaging&rft.au=Ramaswamy%2C+S%3BUluer%2C+M+C%3BLeen%2C+S%3BBajaj%2C+P%3BFishbein%2C+K+W%3BSpencer%2C+R+G&rft.aulast=Ramaswamy&rft.aufirst=S&rft.date=2008-09-01&rft.volume=14&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+C%3A+Methods&rft.issn=19373384&rft_id=info:doi/10.1089%2Ften.tec.2007.0423 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Glycosaminoglycans; hydrogels; Cartilage; Computed tomography; Gadolinium; Magnetic resonance imaging; oxides; Chondrocytes; Tissue engineering; Mechanical properties DO - http://dx.doi.org/10.1089/ten.tec.2007.0423 ER - TY - JOUR T1 - Intervertebral Disc Tissue Engineering Using a Novel Hyaluronic Acid-Nanofibrous Scaffold (HANFS) Amalgam AN - 20972865; 8552515 AB - Degeneration of the intervertebral disc (IVD) represents a significant musculoskeletal disease burden. Although spinal fusion has some efficacy in pain management, spine biomechanics is ultimately compromised. In addition, there is inherent limitation of hardware-based IVD replacement prostheses, which underscores the importance of biological approaches to disc repair. In this study, we have seeded multipotent, adult human mesenchymal stem cells (MSCs) into a novel biomaterial amalgam to develop a biphasic construct that consisted of electrospun, biodegradable nanofibrous scaffold (NFS) enveloping a hyaluronic acid (HA) hydrogel center. The seeded MSCs were induced to undergo chondrogenesis in vitro in the presence of transforming growth factor- beta for up to 28 days. The cartilaginous hyaluronic acid-nanofibrous scaffold (HANFS) construct architecturally resembled a native IVD, with an outer annulus fibrosus-like region and inner nucleus pulposus-like region. Histological and biochemical analyses, immunohistochemistry, and gene expression profiling revealed the time-dependent development of chondrocytic phenotype of the seeded cells. The cells also maintain the microarchitecture of a native IVD. Taken together, these findings suggest the prototypic potential of MSC-seeded HANFS constructs for the tissue engineering of biological replacements of degenerated IVD. JF - Tissue Engineering, Part A: Tissue Engineering AU - Nesti, L J AU - Li, W-J AU - Shanti, R M AU - Jiang, Y J AU - Jackson, W AU - Freedman, BA AU - Kuklo, T R AU - Giuliani, J R AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1503, MSC 8022, Bethesda, MD 20892-8022, USA, tuanr@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1527 EP - 1538 VL - 14 IS - 9 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Hyaluronic acid KW - Biochemical analysis KW - Pain KW - Tissue engineering KW - scaffolds KW - Intervertebral discs KW - Gene expression KW - Stem cells KW - Spine KW - hydrogels KW - Biomaterials KW - Transforming growth factor-^b KW - Degeneration KW - Mesenchyme KW - Nuclei KW - Immunohistochemistry KW - Biomechanics KW - Chondrogenesis KW - Prosthetics KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20972865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Intervertebral+Disc+Tissue+Engineering+Using+a+Novel+Hyaluronic+Acid-Nanofibrous+Scaffold+%28HANFS%29+Amalgam&rft.au=Nesti%2C+L+J%3BLi%2C+W-J%3BShanti%2C+R+M%3BJiang%2C+Y+J%3BJackson%2C+W%3BFreedman%2C+BA%3BKuklo%2C+T+R%3BGiuliani%2C+J+R%3BTuan%2C+R+S&rft.aulast=Nesti&rft.aufirst=L&rft.date=2008-09-01&rft.volume=14&rft.issue=9&rft.spage=1527&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2008.0215 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tissue engineering; Intervertebral discs; scaffolds; Gene expression; Nuclei; Spine; Prosthetics; Biomaterials; Transforming growth factor-^b; Biomechanics; Hyaluronic acid; Mesenchyme; hydrogels; Biochemical analysis; Degeneration; Immunohistochemistry; Stem cells; Chondrogenesis; Pain DO - http://dx.doi.org/10.1089/ten.tea.2008.0215 ER -