TY - JOUR T1 - Visual and proprioceptive feedback improves knee joint position sense AN - 954610455; 14081271 AB - Joint position sense (JPS), one method to assess proprioception, is the ability to replicate a target limb position. Feedback is commonly used to improve motor performance but it has not been demonstrated to improve JPS. The purpose of this study was to determine if feedback decreases error associated with knee JPS at three movement velocities. Healthy volunteers sat with their hip and knees flexed. The knee was passively extended at three velocities (0.5, 2, and 10 degree /s). Subjects were instructed to stop knee motion, via a thumb switch, at a 20 degree knee flexion target. Following movement, each subject received visual and proprioceptive feedback indicating final leg position relative to the target position. Movement velocities and times (4s, 5s, 6s) were randomly presented so subjects could not predict the target position. Measures of JPS included constant error (CE), absolute error (AE), variable error (VE), and percent correct (%CORR). Significant decreases in CE, AE, and VE as well as an increase in %CORR were demonstrated. The majority of JPS improvement (85%) occurred by the tenth trial. Short-term improvements in JPS may be the result of temporary CNS adaptations via feedback that was provided to subjects. Long-term learning of JPS enhancement needs further investigation. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Brindle, Timothy J AU - Mizelle, J C AU - Lebiedowska, Maria K AU - Miller, Jeri L AU - Stanhope, Steven J AD - Biomechanics Laboratory, National Institutes of Health, Building 10 CRC, Room 1-1469 10 Center Drive MCS 1604, Bethesda, MD, 20892, USA, Tbrindle@cc.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 40 EP - 47 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 17 IS - 1 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Feedback KW - Fingers KW - Hips KW - Joints KW - Knees KW - Movement KW - Sports KW - Surgery KW - Velocity KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954610455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=Visual+and+proprioceptive+feedback+improves+knee+joint+position+sense&rft.au=Brindle%2C+Timothy+J%3BMizelle%2C+J+C%3BLebiedowska%2C+Maria+K%3BMiller%2C+Jeri+L%3BStanhope%2C+Steven+J&rft.aulast=Brindle&rft.aufirst=Timothy&rft.date=2009-01-01&rft.volume=17&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-008-0638-3 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Fingers; Surgery; Knees; Velocity; Feedback; Sports; Movement; Hips; Joints DO - http://dx.doi.org/10.1007/s00167-008-0638-3 ER - TY - JOUR T1 - A Comprehensive Review of the Literature on Exposure to Metalworking Fluids AN - 899165765; 15153489 AB - An extensive literature review was conducted of studies with exposure measurements to metalworking fluids (MWFs). A database of 155 arithmetic means based on 9379 aerosol measurements from published studies was compiled. Weighted arithmetic means (WAMs) and their variance calculated across studies were summarized based on decade (prior to 1970s through 2000s), industry (auto, auto parts, small job shops, and others), operation (grinding and machining), and fluid type (straight, soluble, synthetic, and semisynthetic). Total mass and total extractable mass measurements that were simultaneously collected were compared. Average concentrations by size fractions and mass median aerodynamic diameters (MMADs) were also analyzed. Analysis of the WAMs indicated a reduction in exposure levels over time regardless of industry or type of operation or fluid, with mean levels prior to the 1970s of 5.4 mg/m3, which dropped to 2.5 mg/m3 in the 1970s, to 1.2 mg/m3 in the 1980s, and to 0.5 mg/m3 in the 1990s. No further reduction was seen in the 2000s. A comparison by industry, operation, and fluid type found no consistent patterns in the measurement results. The percent extractable mass in the total aerosol samples varied by fluid type, with an average 84% in straight fluids, 58% in synthetic fluids, 56% in soluble fluids, and 42% in the semisynthetic fluids. Exposure means from the thoracic fraction (0.3-0.5 mg/m3) were slightly less than those for total aerosol for both the 1990s and 2000s, the only decades for which thoracic data were available. Respirable means did not change from the 1980s to the 2000s (generally about 0.2-0.3 mg/m3). The MMADs of the MWF aerosols averaged 4-6 Delta *mm. These measurement data indicate a clear reduction of exposure levels over time. They will be used for the retrospective assessment of exposure levels to MWFs in a population-based, case-control study of bladder cancer. JF - Journal of Occupational and Environmental Hygiene AU - Park, Donguk AU - Stewart, Patricia A AU - Coble, Joseph B AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland Y1 - 2009 PY - 2009 DA - 2009 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 6 IS - 9 SN - 1545-9624, 1545-9624 KW - Health & Safety Science Abstracts KW - urinary bladder KW - Aerosols KW - Reviews KW - Aerodynamics KW - metal-working fluids KW - Air sampling KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899165765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=A+Comprehensive+Review+of+the+Literature+on+Exposure+to+Metalworking+Fluids&rft.au=Park%2C+Donguk%3BStewart%2C+Patricia+A%3BCoble%2C+Joseph+B&rft.aulast=Park&rft.aufirst=Donguk&rft.date=2009-01-01&rft.volume=6&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459620903065984 L2 - http://www.informaworld.com/smpp/content~db=all~content=a912533614~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - urinary bladder; Aerosols; Aerodynamics; Reviews; Air sampling; metal-working fluids DO - http://dx.doi.org/10.1080/15459620903065984 ER - TY - JOUR T1 - Safety and efficacy of antipsychotic drugs for the behavioral and psychological symptoms of dementia AN - 872139349; 14606947 AB - Antipsychotic drugs are commonly used in the treatment of the behavioral and psychological symptoms of dementia (BPSD). We present a qualitative review of the data on the efficacy and safety of antipsychotic drugs for BPSD. We more specifically examine safety issues with an especial focus on recent research. We examine two safety studies in detail to provide readers with a critical perspective. Typical and atypical antipsychotic drugs both attenuate the severity of BPSD; however, both categories of drugs increase the risk of cerebrovascular and other adverse events, as well as the risk of death. The risk appears greater with the typical drugs, with higher doses, and during the initial weeks of treatment. The risk probably persists for as long as a year after the initiation of treatment. Both drug- and patient-related factors appear to mediate this increase in risk. Antipsychotic drugs should be considered for BPSD only if there is a specific need, or if other treatments have failed; decision-making should be individualized and documented after a risk-benefit analysis. Atypical antipsychotics appear safer than the typical drugs. The lowest effective dose should be used. JF - Indian Journal of Psychiatry AU - Andrade, Chittaranjan AU - Radhakrishnan, Rajiv AD - Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India Y1 - 2009/01// PY - 2009 DA - January 2009 SP - S87 EP - S92 PB - Medknow Publications Pvt. Ltd., A-108/109 Kanara Business Center Mumbai 400075 India VL - 51 IS - 1 SN - 0019-5545, 0019-5545 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Antipsychotics KW - dementia KW - behavioral and psychological symptoms of dementia KW - mortality KW - stroke KW - Risk assessment KW - Mortality KW - Data processing KW - Psychology KW - Decision making KW - Dose-response effects KW - Neuroleptics KW - Reviews KW - Dementia disorders KW - dementia disorders KW - Drugs KW - Side effects KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872139349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Psychiatry&rft.atitle=Safety+and+efficacy+of+antipsychotic+drugs+for+the+behavioral+and+psychological+symptoms+of+dementia&rft.au=Andrade%2C+Chittaranjan%3BRadhakrishnan%2C+Rajiv&rft.aulast=Andrade&rft.aufirst=Chittaranjan&rft.date=2009-01-01&rft.volume=51&rft.issue=1&rft.spage=S87&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Psychiatry&rft.issn=00195545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Risk assessment; Decision making; Data processing; Reviews; Neuroleptics; Dementia disorders; Drugs; Mortality; Psychology; Dose-response effects; dementia disorders; Side effects ER - TY - JOUR T1 - The contribution of the Department of Veterans Affairs to neuroimaging of aphasia: One perspective AN - 85348357; llba-200920515 AB - Background: The Department of Veterans Affairs (VA) has made important contributions to the neuroimaging of aphasia. Through the affiliations of VA researchers with medical faculties, a broad range of questions has been addressed regarding the structural, metabolic, and functional changes that occur in the brain of individuals who develop aphasia. Aims: This report examines some of the work that has been accomplished by VA researchers using CT, MRI, SPECT, and PET imaging approaches. Main Contribution and Conclusions: The reviewed VA research demonstrates that aphasia results from the dynamic relationships that exist between the impact of structural brain damage on brain function in both damaged and non-damaged regions of the brain. The resulting concepts have led to innovative strategies for the neurorehabilitation of aphasia. Adapted from the source document JF - Aphasiology AU - Metter, Jeffrey E AU - Mlcoch, Anthony AD - National Institute on Aging, Baltimore, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1086 EP - 1100 VL - 23 IS - 9 SN - 0268-7038, 0268-7038 KW - *Aphasia (03400) KW - *Magnetic Resonance Imaging (MRI) (50620) KW - *Neuroimaging Techniques (57245) KW - *Medicine (52500) KW - *Armed Forces (04200) KW - *Brain Damage (09400) KW - *Positron Emission Tomography (PET) (66813) KW - article KW - 6414: language-pathological and normal; aphasia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85348357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=The+contribution+of+the+Department+of+Veterans+Affairs+to+neuroimaging+of+aphasia%3A+One+perspective&rft.au=Metter%2C+Jeffrey+E%3BMlcoch%2C+Anthony&rft.aulast=Metter&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=23&rft.issue=9&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-12-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Neuroimaging Techniques (57245); *Medicine (52500); *Magnetic Resonance Imaging (MRI) (50620); *Positron Emission Tomography (PET) (66813); *Brain Damage (09400); *Armed Forces (04200) ER - TY - JOUR T1 - Targeting Protein Kinase C (PKC) and Telomerase by Phenethyl Isothiocyanate (PEITC) Sensitizes PC-3 Cells Towards Chemotherapeutic Drug-Induced Apoptosis AN - 746078779; 12926388 AB - Prostate cancer is the leading cause of cancer-related death in men, incidences of which are increasing gradually in India. Protein kinase C (PKC), an enzyme, gets overexpressed in prostate cancer and results in a resistance to chemotherapy. Telomerase, a reverse transcriptase, is highly activated in prostate cancer cells. Both of these enzymes can be considered as potential molecular markers for prostate cancer. The present study investigates the effects of natural isothiocyanate phenethyl isothiocyanate (PEITC) in modulating the activities of PKC and telomerase in the androgen-independent human prostate adenocarcinoma (PC-3) cell line. We observed that PEITC downregulated the antiapoptotic isoforms (PKC alpha and epsilon) efficiently and zeta moderately. Basal level of PKC delta, a proapoptotic form, was very poor and its modulation was not significant. PEITC also inhibited the activity of telomerase. Studies were conducted to measure the degree of apoptotic cell death induced either by PEITC alone or in combination with adriamycin or etoposide. Apoptosis was evident from the release of mitochondrial cytochrome c, apoptotic index, and by the induction of caspases 3 and 8. PEITC exhibited remarkable efficacy in sensitizing PC-3 cells to undergo cell death by adriamycin and etoposide, which might prove to be of considerable value in synergistic therapy of cancer. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Mukherjee, Sutapa AU - Bhattacharya, Rathindra Kumar AU - Roy, Madhumita AD - Department of Environmental Carcinogenesis & Toxicology, Chittaranjan National Cancer Institute, Kolkata 700 026 Y1 - 2009 PY - 2009 DA - 2009 SP - 269 EP - 282 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 USA VL - 28 IS - 4 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Pollution Abstracts KW - Protein kinase C KW - Apoptosis KW - Pathology KW - Telomerase KW - Chemotherapy KW - Mitochondria KW - Tumor cell lines KW - ISW, India KW - Cytochrome c KW - phenethyl isothiocyanate KW - deltas KW - RNA-directed DNA polymerase KW - prostate cancer KW - Etoposide KW - isothiocyanate KW - Mortality KW - Enzymes KW - Cancer KW - chemotherapy KW - Cytochrome KW - Prostate cancer KW - Caspase-3 KW - Proteins KW - Adenocarcinoma KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746078779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Targeting+Protein+Kinase+C+%28PKC%29+and+Telomerase+by+Phenethyl+Isothiocyanate+%28PEITC%29+Sensitizes+PC-3+Cells+Towards+Chemotherapeutic+Drug-Induced+Apoptosis&rft.au=Mukherjee%2C+Sutapa%3BBhattacharya%2C+Rathindra+Kumar%3BRoy%2C+Madhumita&rft.aulast=Mukherjee&rft.aufirst=Sutapa&rft.date=2009-01-01&rft.volume=28&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Apoptosis; Telomerase; Chemotherapy; Enzymes; Mitochondria; Tumor cell lines; Prostate cancer; Cytochrome c; phenethyl isothiocyanate; Caspase-3; RNA-directed DNA polymerase; Adenocarcinoma; Etoposide; isothiocyanate; Mortality; Cytochrome; Pathology; deltas; Proteins; prostate cancer; chemotherapy; Cancer; ISW, India ER - TY - JOUR T1 - Research Misconduct Policies of Scientific Journals AN - 746009558; 13054696 AB - The purpose of this study was to gather information on the misconduct policies of scientific journals. We contacted editors from a random sample of 399 journals drawn from the ISI Web of Knowledge database. We received 197 responses (49.4% response rate): 54.8% had a policy, and 47.7% had a formal (written) policy; 28.9% had a policy that only outlined procedures for handling misconduct, 15.7% had a policy that only defined misconduct, 10.2% had a policy that included both a definition and procedures; 26.9% of journals had a policy that was generated by the publisher, 13.2% had a policy that was generated by the journal, and 14.7% had a policy that was generated by another source, such as a professional association. We analyzed the relationship between having a policy and impact factor, field of science, publishing house, and nationality. Impact factor was the only variable with a statistically significant association with having a policy. Impact factor was slightly positively associated with whether or not the publisher had a policy, with an odds ratio of 1.49 (P < .0004) per 10 units increase in the impact factor, with a 95% confidence interval (1.20, 1.88). Our research indicates that more than half of scientific journals have developed misconduct policies, but that most of these policies do not define research misconduct and most of these policies were not generated by the journal. JF - Accountability in Research AU - Resnik J.D., DB AU - Peddada, S AU - Brunson, W Jr AD - National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, North Carolina, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 254 EP - 267 VL - 16 IS - 5 SN - 0898-9621, 0898-9621 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746009558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accountability+in+Research&rft.atitle=Research+Misconduct+Policies+of+Scientific+Journals&rft.au=Resnik+J.D.%2C+DB%3BPeddada%2C+S%3BBrunson%2C+W+Jr&rft.aulast=Resnik+J.D.&rft.aufirst=DB&rft.date=2009-01-01&rft.volume=16&rft.issue=5&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Accountability+in+Research&rft.issn=08989621&rft_id=info:doi/10.1080%2F08989620903190299 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/08989620903190299 ER - TY - JOUR T1 - Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers AN - 745698870; 13028073 AB - Organophosphate (OP) and N-methyl-carbamate (CB) insecticides are widely used in agriculture in the US and abroad. These compounds - which inhibit acetylcholinestersase (AChE) enzyme activity - continue to be responsible for a high proportion of pesticide poisonings among US agricultural workers. It is possible that some individuals may be especially susceptible to health effects related to OP/CB exposure. The paraoxonase (PON1) enzyme metabolizes the highly toxic oxon forms of some OPs, and an individual's PON1 status may be an important determinant of his or her sensitivity to these chemicals. This chapter discusses methods used to characterize the PON1 status of individuals and reviews previous epidemiologic studies that have evaluated PON1-related sensitivity to OPs in relation to various health endpoints. It also describes an ongoing longitudinal study among OP-exposed agricultural pesticide handlers who are participating in a recently implemented cholinesterase monitoring program in Washington State. This study will evaluate handlers' PON1 status as a hypothesized determinant of butyrylcholinesterase (BuChE) inhibition. Such studies will be useful to determine how regulatory risk assessments might account for differences in PON1-related OP sensitivity when characterizing inter-individual variability in risk related to OP exposure. Recent work assessing newer and more sensitive biomarkers of OP exposure is also discussed briefly in this chapter. JF - Advances in Experimental Medicine and Biology AU - Hofmann, J N AU - Keifer, M C AU - Checkoway, H AU - De Roos, AJ AU - Farin, F M AU - Fenske, R A AU - Richter, R J AU - van Belle, G AU - Furlong, CE AD - Division of Cancer Epidemilogy and Genetics, National Cancer Institute, Bethesda, MD, USA, hofmannjn@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 19 EP - 28 VL - 660 SN - 0065-2598, 0065-2598 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Agriculture KW - Risk assessment KW - Poisoning KW - Handlers KW - Enzymes KW - Aryldialkylphosphatase KW - organophosphates KW - Cholinesterase KW - biomarkers KW - Insecticides KW - Pesticides KW - Occupational exposure KW - W 30940:Products KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745698870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Experimental+Medicine+and+Biology&rft.atitle=Biomarkers+of+Sensitivity+and+Exposure+in+Washington+State+Pesticide+Handlers&rft.au=Hofmann%2C+J+N%3BKeifer%2C+M+C%3BCheckoway%2C+H%3BDe+Roos%2C+AJ%3BFarin%2C+F+M%3BFenske%2C+R+A%3BRichter%2C+R+J%3Bvan+Belle%2C+G%3BFurlong%2C+CE&rft.aulast=Hofmann&rft.aufirst=J&rft.date=2009-01-01&rft.volume=660&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Advances+in+Experimental+Medicine+and+Biology&rft.issn=00652598&rft_id=info:doi/10.1007%2F978-1-60761-350-3_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Agriculture; Insecticides; Pesticides; Poisoning; Aryldialkylphosphatase; Enzymes; Handlers; organophosphates; Cholinesterase; biomarkers; Occupational exposure DO - http://dx.doi.org/10.1007/978-1-60761-350-3_3 ER - TY - JOUR T1 - Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent AN - 744698970; 11741218 AB - Background The obligate intracellular bacterial pathogen Coxiella burnetii causes the zoonosis Q fever. The intracellular niche of C. burnetii has led to the assumption that cell-mediated immunity is the most important immune component for protection against this pathogen. However, passive immunization with immune serum can protect naive animals from challenge with virulent C. burnetii, indicating a role for antibody (Ab) in protection. The mechanism of this Ab-mediated protection is unknown. Therefore, we conducted a study to determine whether Fc receptors (FcR) or complement contribute to Ab-mediated immunity (AMI) to C. burnetii. Results Virulent C. burnetii infects and replicates within human dendritic cells (DC) without inducing their maturation or activation. We investigated the effects of Ab opsonized C. burnetii on human monocyte-derived and murine bone marrow-derived DC. Infection of DC with Ab-opsonized C. burnetii resulted in increased expression of maturation markers and inflammatory cytokine production. Bacteria that had been incubated with naive serum had minimal effect on DC, similar to virulent C. burnetii alone. The effect of Ab opsonized C. burnetii on DC was FcR dependent as evidenced by a reduced response of DC from FcR knockout (FcR k/o) compared to C57Bl/6 (B6) mice. To address the potential role of FcR in Ab-mediated protection in vivo, we compared the response of passively immunized FcR k/o mice to the B6 controls. Interestingly, we found that FcR are not essential for AMI to C. burnetii in vivo. We subsequently examined the role of complement in AMI by passively immunizing and challenging several different strains of complement-deficient mice and found that AMI to C. burnetii is also complement-independent. Conclusion Despite our data showing FcR-dependent stimulation of DC in vitro, Ab-mediated immunity to C. burnetii in vivo is FcR-independent. We also found that passive immunity to this pathogen is independent of complement. JF - BMC Immunology AU - Shannon, Jeffrey G AU - Cockrell, Diane C AU - Takahashi, Kazue AU - Stahl, Gregory L AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA, rheinzen@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 26 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bacteria KW - Immune serum KW - Data processing KW - Bone marrow KW - Pathogens KW - Infection KW - Cell activation KW - Fc receptors KW - Inflammation KW - Immunity (passive) KW - Coxiella burnetii KW - Dendritic cells KW - Antibodies KW - Immunity (cell-mediated) KW - Cytokines KW - Immunization (passive) KW - Monocytes KW - Q fever KW - Opsonization KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744698970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Immunology&rft.atitle=Antibody-mediated+immunity+to+the+obligate+intracellular+bacterial+pathogen+Coxiella+burnetii+is+Fc+receptor-+and+complement-independent&rft.au=Shannon%2C+Jeffrey+G%3BCockrell%2C+Diane+C%3BTakahashi%2C+Kazue%3BStahl%2C+Gregory+L%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=10&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=BMC+Immunology&rft.issn=1471-2172&rft_id=info:doi/10.1186%2F1471-2172-10-26 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2017-02-01 N1 - SubjectsTermNotLitGenreText - Data processing; Immune serum; Bone marrow; Pathogens; Infection; Inflammation; Fc receptors; Cell activation; Immunity (passive); Dendritic cells; Antibodies; Immunity (cell-mediated); Cytokines; Immunization (passive); Monocytes; Q fever; Opsonization; Coxiella burnetii; Bacteria DO - http://dx.doi.org/10.1186/1471-2172-10-26 ER - TY - JOUR T1 - Chronic Exposures to Cholinesterase-inhibiting Pesticides Adversely Affect Respiratory Health of Agricultural Workers in India AN - 744670208; 12554778 AB - Objective: The impact of long term exposure to cholinesterase (ChE)- inhibiting organophosphate (OP) and carbamate (C) pesticides on the respiratory health of agricultural workers in India was investigated. Methods: Three hundred and seventy-six nonsmoking agricultural workers (median age 41 yr) from eastern India who sprayed OP and C pesticides in the field and 348 age- and sex-matched control subjects with non-agricultural occupations from the same locality were enrolled. Prevalence of respiratory symptoms was obtained by questionnaire survey, and pulmonary function tests were carried out by spirometry. Chronic obstructive pulmonary disease (COPD) was diagnosed by the Global Obstructive Lung Disease (GOLD) criteria, and erythrocyte acetylcholinesterase (AChE) was measured by the Ellman method. Results: Agricultural workers had greater prevalences of upper and lower respiratory symptoms, and appreciable reduction in spirometric measurements. Overall, lung function reduction was noted in 48.9% of agricultural workers compared with 22.7% of control, and a restrictive type of deficit was predominant. COPD was diagnosed in 10.9% of agricultural workers compared with 3.4% of controls (p-0.05 in [chi] super(2) test), and the severity of the disease was greater in agricultural workers. Red blood cell (RBC) AChE was lowered by 34.2% in agricultural workers, and the fall in AChE level was positively associated with respiratory symptoms, lung function decrement and COPD after controlling for education and income as potential confounders. Conclusions: Long-term exposure to cholinesterase-inhibiting agricultural pesticides currently in use in India is associated with a reduction in lung function, COPD and a rise in respiratory symptoms. JF - Journal of Occupational Health AU - Chakraborty, Sreeparna AU - Mukherjee, Sayali AU - Roychoudhury, Sanghita AU - Siddique, Shabana AU - Lahiri, Twisha AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute Y1 - 2009 PY - 2009 DA - 2009 SP - 488 EP - 497 PB - Japan Society for Occupational Health, Public Health Bldg., 1-29-8 Shinjuku Shinjuku-ku Tokyo 190 Japan VL - 51 IS - 6 SN - 1341-9145, 1341-9145 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Acetylcholinesterase KW - Occupational exposure KW - India KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744670208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Health&rft.atitle=Chronic+Exposures+to+Cholinesterase-inhibiting+Pesticides+Adversely+Affect+Respiratory+Health+of+Agricultural+Workers+in+India&rft.au=Chakraborty%2C+Sreeparna%3BMukherjee%2C+Sayali%3BRoychoudhury%2C+Sanghita%3BSiddique%2C+Shabana%3BLahiri%2C+Twisha%3BRay%2C+Manas+Ranjan&rft.aulast=Chakraborty&rft.aufirst=Sreeparna&rft.date=2009-01-01&rft.volume=51&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health&rft.issn=13419145&rft_id=info:doi/10.1539%2Fjoh.L9070 L2 - http://www.jstage.jst.go.jp/article/joh/51/6/488/_pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Occupational exposure; India DO - http://dx.doi.org/10.1539/joh.L9070 ER - TY - JOUR T1 - Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic AN - 744615758; 13002509 AB - In recent years, various nanotechnology platforms in the area of medical biology, including both diagnostics and therapy, have gained remarkable attention. Moreover, research and development of engineered multifunctional nanoparticles as pharmaceutical drug carriers have spurred exponential growth in applications to medicine in the last decade. Design principles of these nanoparticles, including nanoemulsions, dendrimers, nano-gold, liposomes, drug-carrier conjugates, antibody-drug complexes, and magnetic nanoparticles, are primarily based on unique assemblies of synthetic, natural, or biological components, including but not limited to synthetic polymers, metal ions, oils, and lipids as their building blocks. However, the potential success of these particles in the clinic relies on consideration of important parameters such as nanoparticle fabrication strategies, their physical properties, drug loading efficiencies, drug release potential, and, most importantly, minimum toxicity of the carrier itself. Among these, lipid-based nanoparticles bear the advantage of being the least toxic for in vivo applications, and significant progress has been made in the area of DNA/RNA and drug delivery using lipid-based nanoassemblies. In this review, we will primarily focus on the recent advances and updates on lipid-based nanoparticles for their projected applications in drug delivery. We begin with a review of current activities in the field of liposomes (the so-called honorary nanoparticles), and challenging issues of targeting and triggering will be discussed in detail. We will further describe nanoparticles derived from a novel class of amphipathic lipids called bolaamphiphiles with unique lipid assembly features that have been recently examined as drug/DNA delivery vehicles. Finally, an overview of an emerging novel class of particles (based on lipid components other than phospholipids), solid lipid nanoparticles and nanostructured lipid carriers will be presented. We conclude with a few examples of clinically successful formulations of currently available lipid-based nanoparticles. JF - Critical Reviews in Therapeutic Drug Carrier Systems AU - Puri, Anu AU - Loomis, Kristin AU - Smith, Brandon AU - Lee, Jae-Ho AU - Yavlovich, Amichai AU - Heldman, Eliahu AU - Blumenthal, Robert AD - Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 523 EP - 580 PB - Begell House Inc. VL - 26 IS - 6 SN - 0743-4863, 0743-4863 KW - Biotechnology and Bioengineering Abstracts KW - Ions KW - Metals KW - Drug delivery KW - Lipids KW - Oils KW - Toxicity KW - Liposomes KW - RNA KW - Reviews KW - DNA KW - Pharmaceuticals KW - nanoparticles KW - Phospholipids KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744615758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Therapeutic+Drug+Carrier+Systems&rft.atitle=Lipid-Based+Nanoparticles+as+Pharmaceutical+Drug+Carriers%3A+From+Concepts+to+Clinic&rft.au=Puri%2C+Anu%3BLoomis%2C+Kristin%3BSmith%2C+Brandon%3BLee%2C+Jae-Ho%3BYavlovich%2C+Amichai%3BHeldman%2C+Eliahu%3BBlumenthal%2C+Robert&rft.aulast=Puri&rft.aufirst=Anu&rft.date=2009-01-01&rft.volume=26&rft.issue=6&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Therapeutic+Drug+Carrier+Systems&rft.issn=07434863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Drug delivery; Metals; Ions; Lipids; Oils; Toxicity; Liposomes; RNA; Reviews; DNA; Pharmaceuticals; nanoparticles; nanotechnology; Phospholipids ER - TY - JOUR T1 - Social Media Use in the United States: Implications for Health Communication AN - 742900242; 201006703 AB - Background: Given the rapid changes in the communication landscape brought about by participative Internet use and social media, it is important to develop a better understanding of these technologies and their impact on health communication. The first step in this effort is to identify the characteristics of current social media users. Up-to-date reporting of current social media use will help monitor the growth of social media and inform health promotion/communication efforts aiming to effectively utilize social media. Objective: The purpose of the study is to identify the sociodemographic and health-related factors associated with current adult social media users in the United States. Results: Approximately 69% of US adults reported having access to the Internet in 2007. Among Internet users, 5% participated in an online support group, 7% reported blogging, and 23% used a social networking site. Multivariate analysis found that younger age was the only significant predictor of blogging and social networking site participation; a statistically significant linear relationship was observed, with younger categories reporting more frequent use. Younger age, poorer subjective health, and a personal cancer experience predicted support group participation. In general, social media are penetrating the US population independent of education, race/ethnicity, or health care access. Conclusions: Recent growth of social media is not uniformly distributed across age groups; therefore, health communication programs utilizing social media must first consider the age of the targeted population to help ensure that messages reach the intended audience. While racial/ethnic and health statusrelated disparities exist in Internet access, among those with Internet access, these characteristics do not affect social media use. This finding suggests that the new technologies, represented by social media, may be changing the communication pattern throughout the United States. Adapted from the source document. JF - Journal of Medical Internet Research AU - ChoU, Wen-ying Sylvia AU - Hunt, Yvonne M AU - Beckjord, Ellen Burke AU - Moser, Richard P AU - Hesse, Bradford W AD - National Cancer Institute, Health Communication and Informatics Research Branch, 6130 Executive Blvd (EPN), 4051A, Bethesda, MD 20892-7365 Email: chouws@mail.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth Innovation, Toronto, Canada VL - 11 IS - 4 SN - 1438-8871, 1438-8871 KW - USA KW - Internet KW - social media KW - social networking KW - demography KW - population surveillance KW - eHealth, new technologies KW - health communication KW - Web 2.0 KW - Social networks KW - Consumer health information KW - article KW - 14.11: COMMUNICATIONS AND INFORMATION TECHNOLOGY - NETWORKS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742900242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Social+Media+Use+in+the+United+States%3A+Implications+for+Health+Communication&rft.au=ChoU%2C+Wen-ying+Sylvia%3BHunt%2C+Yvonne+M%3BBeckjord%2C+Ellen+Burke%3BMoser%2C+Richard+P%3BHesse%2C+Bradford+W&rft.aulast=ChoU&rft.aufirst=Wen-ying&rft.date=2009-01-01&rft.volume=11&rft.issue=4&rft.spage=NP&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/ L2 - http://www.jmir.org/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumer health information; Internet; Social networks; Web 2.0 ER - TY - JOUR T1 - Neurotrapping: cellular screens to identify the neural substrates of behavior in Drosophila. AN - 734164854; 19949456 AB - The availability of new tools for manipulating neuronal activity, coupled with the development of increasingly sophisticated techniques for targeting these tools to subsets of cells in living, behaving animals, is permitting neuroscientists to tease apart brain circuits by a method akin to classical mutagenesis. Just as mutagenesis can be used to introduce changes into an organism's DNA to identify the genes required for a given biological process, changes in activity can be introduced into the nervous system to identify the cells required for a given behavior. If the changes are introduced randomly, the cells can be identified without any prior knowledge of their properties. This strategy, which we refer to here as "neurotrapping," has been implemented most effectively in Drosophila, where transgenes capable of either suppressing or stimulating neuronal activity can be reproducibly targeted to arbitrary subsets of neurons using so-called "enhancer-trap" techniques. By screening large numbers of enhancer-trap lines, experimenters have been able to identify groups of neurons which, when suppressed (or, in some cases, activated), alter a specific behavior. Parsing these groups of neurons to identify the minimal subset required for generating a behavior has proved difficult, but emerging tools that permit refined transgene targeting are increasing the resolution of the screening techniques. Some of the most recent neurotrapping screens have identified physiological substrates of behavior at the single neuron level. JF - Frontiers in molecular neuroscience AU - White, Benjamin H AU - Peabody, Nathan C AD - Laboratory of Molecular Biology, National Institute of Mental Health Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 20 VL - 2 KW - excitability KW - synaptic KW - genetic KW - neural networks KW - circuits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734164854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Public+Health&rft.atitle=Gene+by+Environment+Interaction+in+Asthma&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Public+Health&rft.issn=01637525&rft_id=info:doi/10.1146%2Fannurev.publhealth.031308.100151 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2009-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Front Mol Neurosci. 2009;2:13 [19750193] Neuron. 2009 Aug 13;63(3):305-15 [19679071] Front Mol Neurosci. 2009;2:21 [19915728] Proc Natl Acad Sci U S A. 1990 Oct;87(20):7844-8 [2236000] Neuron. 1995 Feb;14(2):341-51 [7857643] J Neurosci. 2001 Mar 1;21(5):1523-31 [11222642] Trends Neurosci. 2001 May;24(5):251-4 [11311363] Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12602-7 [11675496] J Neurobiol. 2002 Feb 15;50(3):221-33 [11810637] Cell. 2002 May 17;109(4):485-95 [12086605] J Neurobiol. 2003 May;55(2):233-46 [12672020] Neuron. 2004 May 27;42(4):553-66 [15157418] J Neurobiol. 2005 Jun;63(3):235-54 [15751025] Cell. 2005 Jun 3;121(5):795-807 [15935765] J Neurosci. 2006 Jan 11;26(2):479-89 [16407545] Nature. 2006 Jun 8;441(7094):757-60 [16760980] Curr Biol. 2006 Sep 5;16(17):1741-7 [16950113] Nature. 2007 Jan 11;445(7124):168-76 [17151600] Mol Cell Neurosci. 2007 Jun;35(2):383-96 [17498969] Nature. 2007 Nov 15;450(7168):420-4 [17943086] Nat Neurosci. 2008 May;11(5):538-40 [18391943] Neuron. 2008 Jul 31;59(2):322-35 [18667159] PLoS Biol. 2008 Nov 4;6(11):e273 [18986214] Nat Neurosci. 2009 Mar;12(3):356-62 [19219037] Curr Biol. 2009 Apr 14;19(7):613-9 [19303299] Adv Genet. 2009;65:79-143 [19615532] Front Mol Neurosci. 2009;2:11 [19738923] Front Mol Neurosci. 2009;2:12 [19753326] Science. 1995 Feb 10;267(5199):902-5 [7846534] Development. 1993 Jun;118(2):401-15 [8223268] Genetics. 1999 Mar;151(3):1093-101 [10049925] J Neurobiol. 2001 May;47(2):81-92 [11291099] Neuron. 2001 Sep 13;31(5):699-711 [11567611] Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12596-601 [11675495] Curr Biol. 2001 Dec 11;11(24):R1041-53 [11747845] Adv Genet. 2002;47:1-47 [12000095] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13232-7 [12239352] J Neurosci. 2002 Nov 1;22(21):9490-501 [12417673] J Neurogenet. 2002 Oct-Dec;16(4):205-28 [12745632] Trends Genet. 2004 Aug;20(8):384-91 [15262411] Nature. 2004 Oct 14;431(7010):854-9 [15372051] Cell. 2005 Apr 8;121(1):141-52 [15820685] Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12483-8 [16116081] J Neurosci. 2006 Jan 11;26(2):573-84 [16407556] Nature. 2006 Jun 8;441(7094):753-6 [16760979] J Comp Neurol. 2006 Sep 10;498(2):194-203 [16856137] J Neurosci. 2006 Oct 11;26(41):10380-6 [17035522] Neuron. 2006 Nov 9;52(3):425-36 [17088209] Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5199-204 [17360325] Nature. 2007 Jul 12;448(7150):151-6 [17625558] Curr Opin Neurobiol. 2007 Oct;17(5):572-80 [18024005] Neuron. 2008 Mar 13;57(5):634-60 [18341986] Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9715-20 [18621688] Neuron. 2008 Oct 23;60(2):328-42 [18957224] Neuron. 2008 Nov 26;60(4):672-82 [19038223] Neuron. 2009 Feb 12;61(3):373-84 [19217375] J Neurosci. 2009 Mar 18;29(11):3343-53 [19295141] Science. 2009 May 22;324(5930):1080-4 [19389999] Nature. 2009 Jun 4;459(7247):698-702 [19396159] Nature. 2009 Sep 17;461(7262):407-10 [19759620] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3389/neuro.02.020.2009 ER - TY - JOUR T1 - Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA). AN - 734130413; 19897081 AB - (+/-)-3,4-Methylenedioxymethamphetamine (MDMA) is a commonly abused illicit drug which affects multiple organ systems. In animals, high-dose administration of MDMA produces deficits in serotonin (5-HT) neurons (e.g., depletion of forebrain 5-HT) that have been viewed as neurotoxicity. Recent data implicate MDMA in the development of valvular heart disease (VHD). The present paper reviews several issues related to MDMA-associated neural and cardiac toxicities. The hypothesis of MDMA neurotoxicity in rats is evaluated in terms of the effects of MDMA on monoamine neurons, the use of scaling methods to extrapolate MDMA doses across species, and functional consequences of MDMA exposure. A potential treatment regimen (l-5-hydroxytryptophan plus carbidopa) for MDMA-associated neural deficits is discussed. The pathogenesis of MDMA-associated VHD is reviewed with specific reference to the role of valvular 5-HT(2B) receptors. We conclude that pharmacological effects of MDMA occur at the same doses in rats and humans. High doses of MDMA that produce 5-HT depletions in rats are associated with tolerance and impaired 5-HT release. Doses of MDMA that fail to deplete 5-HT in rats can cause persistent behavioral dysfunction, suggesting even moderate doses may pose risks. Finally, the MDMA metabolite, 3,4-methylenedioxyamphetamine (MDA), is a potent 5-HT(2B) agonist which could contribute to the increased risk of VHD observed in heavy MDMA users. JF - International review of neurobiology AU - Baumann, Michael H AU - Rothman, Richard B AD - Clinical Psychopharmacology Section, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, Maryland 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 257 EP - 296 VL - 88 SN - 0074-7742, 0074-7742 KW - Serotonin Agents KW - 0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Rats KW - Animals KW - Neurons -- drug effects KW - Humans KW - Neurotoxicity Syndromes -- physiopathology KW - Heart Valve Diseases -- chemically induced KW - Brain -- drug effects KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Heart -- drug effects KW - Serotonin Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734130413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Neural+and+cardiac+toxicities+associated+with+3%2C4-methylenedioxymethamphetamine+%28MDMA%29.&rft.au=Baumann%2C+Michael+H%3BRothman%2C+Richard+B&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988010-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-08 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Neurosci. 1990 Jul;13(7):290-6 [1695406] Ann N Y Acad Sci. 1990;600:649-61; discussion 661-4 [1979216] Neuropharmacology. 1990 Nov;29(11):1099-101 [1982341] Annu Rev Pharmacol Toxicol. 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Oct;1025:465-71 [15542750] Neurotox Res. 2004;6(7-8):589-614 [15639791] Br J Pharmacol. 2005 Jan;144(2):231-41 [15665862] J Psychopharmacol. 2005 Jan;19(1):71-83 [15671132] Neuropsychopharmacology. 2005 Mar;30(3):550-60 [15496938] J Exp Biol. 2005 May;208(Pt 9):1611-9 [15855392] Drug Alcohol Depend. 2006 Jan 4;81(1):27-36 [15975736] Neuropsychopharmacology. 2006 Feb;31(2):339-50 [15999148] Synapse. 2006 Apr;59(5):277-89 [16416445] J Psychopharmacol. 2006 Mar;20(2):211-25 [16510479] Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):377-87 [16863450] Curr Top Med Chem. 2006;6(17):1845-59 [17017961] Psychopharmacology (Berl). 2007 Jan;189(4):407-24 [16541247] N Engl J Med. 2007 Jan 4;356(1):6-9 [17202450] Pharmacol Biochem Behav. 2007 Apr;86(4):622-30 [17363047] Neuroscience. 2007 Aug 10;148(1):212-20 [17629409] Am J Cardiol. 2007 Nov 1;100(9):1442-5 [17950805] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0074-7742(09)88010-0 ER - TY - JOUR T1 - Acute methamphetamine intoxication: brain hyperthermia, blood-brain barrier, brain edema, and morphological cell abnormalities. AN - 734130085; 19897075 AB - Methamphetamine (METH) is a powerful and often abused stimulant with potent addictive and neurotoxic properties. While it is generally assumed that multiple chemical substances released in the brain following METH-induced metabolic activation (or oxidative stress) are primary factors underlying damage of neural cells, in this work we present data suggesting a role of brain hyperthermia and associated leakage of the blood-brain barrier (BBB) in acute METH-induced toxicity. First, we show that METH induces a dose-dependent brain and body hyperthermia, which is strongly potentiated by associated physiological activation and in warm environments that prevent proper heat dissipation to the external environment. Second, we demonstrate that acute METH intoxication induces robust, widespread but structure-specific leakage of the BBB, acute glial activation, and increased water content (edema), which are related to drug-induced brain hyperthermia. Third, we document widespread morphological abnormalities of brain cells, including neurons, glia, epithelial, and endothelial cells developing rapidly during acute METH intoxication. These structural abnormalities are tightly related to the extent of brain hyperthermia, leakage of the BBB, and brain edema. While it is unclear whether these rapidly developed morphological abnormalities are reversible, this study demonstrates that METH induces multiple functional and structural perturbations in the brain, determining its acute toxicity and possibly contributing to neurotoxicity. JF - International review of neurobiology AU - Kiyatkin, Eugene A AU - Sharma, Hari S AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 65 EP - 100 VL - 88 SN - 0074-7742, 0074-7742 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Fever -- chemically induced KW - Animals KW - Neuroglia -- pathology KW - Neurons -- drug effects KW - Humans KW - Poisoning KW - Neuroglia -- drug effects KW - Neurons -- pathology KW - Blood-Brain Barrier -- drug effects KW - Brain Edema -- chemically induced KW - Brain -- drug effects KW - Methamphetamine -- poisoning KW - Central Nervous System Stimulants -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734130085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Acute+methamphetamine+intoxication%3A+brain+hyperthermia%2C+blood-brain+barrier%2C+brain+edema%2C+and+morphological+cell+abnormalities.&rft.au=Kiyatkin%2C+Eugene+A%3BSharma%2C+Hari+S&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988004-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-08 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Hyperthermia. 2000 Jan-Feb;16(1):73-83 [10669318] J Chem Neuroanat. 2009 Jan;37(1):18-32 [18773954] Eur J Pharmacol. 2000 Dec 15;409(3):265-71 [11108820] Brain Res. 2001 Jan 5;888(1):117-127 [11146058] Glia. 2001 Apr 15;34(2):134-42 [11307162] Brain Res. 2001 Jun 29;905(1-2):21-5 [11423075] CMAJ. 2001 Oct 2;165(7):917-28 [11599334] J Appl Physiol (1985). 2002 Jun;92(6):2667-79 [12015388] Di Yi Jun Yi Da Xue Xue Bao. 2003 Jan;23(1):21-4 [12527507] Environ Res. 2003 May;92(1):48-53 [12706754] J Neurosci. 2003 May 1;23(9):3924-9 [12736362] Int J Hyperthermia. 2003 May-Jun;19(3):252-66 [12745971] Int J Hyperthermia. 2003 May-Jun;19(3):325-54 [12745974] Spinal Cord. 2003 Jul;41(7):369-78 [12815368] Neurobiol Aging. 2003 May-Jun;24 Suppl 1:S123-7; discussion S131 [12829120] Neurochem Res. 2003 Aug;28(8):1163-73 [12834255] Eur J Neurosci. 2004 Jul;20(1):51-8 [15245478] Neuroradiology. 2004 Jul;46(7):565-70 [15258709] Can Med Assoc J. 1975 Feb 8;112(3):299-304 [1089034] Experientia. 1975 Dec 15;31(12):1436-7 [1213067] J Neurosurg. 1977 Oct;47(4):525-31 [903805] Brain Res. 1980 Jul 7;193(1):153-63 [7378814] Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(7):1016-20 [4041105] J Neurol Sci. 1986 Jan;72(1):61-76 [2936871] Alcohol Drug Res. 1987;7(3):123-34 [2881551] Am J Physiol. 1988 Feb;254(2 Pt 2):H286-91 [3344819] Brain Res. 1989 May 1;486(1):73-8 [2720435] Neuropharmacology. 1989 Oct;28(10):1145-50 [2554183] Brain Res Dev Brain Res. 1990 Oct 1;56(1):47-53 [2279331] Radiat Res. 1991 Apr;126(1):43-51 [1850533] Neuroscience. 1992 Jun;48(4):889-901 [1630627] Neurochem Res. 1992 Sep;17(9):877-85 [1407275] Pharmacol Biochem Behav. 1993 Jan;44(1):87-98 [8094252] Ann N Y Acad Sci. 1993 May 28;679:195-210 [8512183] J Pharmacol Exp Ther. 1994 Aug;270(2):741-51 [8071867] J Pharmacol Exp Ther. 1994 Aug;270(2):752-60 [8071868] Synapse. 1994 Jul;17(3):203-9 [7974204] Brain Res. 1994 Sep 26;658(1-2):33-8 [7530580] J Pharmacol Exp Ther. 1995 Feb;272(2):868-75 [7853205] J Pharmacol Exp Ther. 1995 Dec;275(3):1104-14 [8531070] NIDA Res Monogr. 1996;163:251-76 [8809863] Ann N Y Acad Sci. 1997 Mar 15;813:572-80 [9100936] Hum Cell. 1996 Dec;9(4):353-66 [9183669] Prog Brain Res. 1998;115:241-74 [9632939] J Pharmacol Exp Ther. 1998 Oct;287(1):107-14 [9765328] Eur J Pharmacol. 1998 Dec 18;363(2-3):107-12 [9881575] Jpn J Pharmacol. 1963 Dec;13:230-9 [14097554] Physiol Behav. 2004 Dec 15;83(3):467-74 [15581669] Curr Pharm Des. 2005;11(11):1353-89 [15853669] Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1689-94 [15650123] Brain Res Brain Res Rev. 2005 Dec 1;50(1):27-56 [15890410] AAPS J. 2006;8(2):E413-8 [16808044] Pain. 2006 Sep;124(1-2):211-21 [16806707] Synapse. 2006 Dec 1;60(7):521-32 [16952162] Ann N Y Acad Sci. 2006 Aug;1074:198-224 [17105918] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] Prog Brain Res. 2007;162:173-99 [17645920] Eur J Neurosci. 2007 Sep;26(5):1242-53 [17767502] Neuron. 2008 Jan 24;57(2):178-201 [18215617] Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1240-6 [10801293] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0074-7742(09)88004-5 ER - TY - JOUR T1 - Teratogenicity and hyperprolactinemia. AN - 734041764; 19742198 JF - Indian journal of psychiatry AU - Andrade, Chittaranjan AD - Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 62 EP - 64 VL - 51 IS - 1 SN - 0019-5545, 0019-5545 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734041764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+psychiatry&rft.atitle=Teratogenicity+and+hyperprolactinemia.&rft.au=Andrade%2C+Chittaranjan&rft.aulast=Andrade&rft.aufirst=Chittaranjan&rft.date=2009-01-01&rft.volume=51&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+psychiatry&rft.issn=00195545&rft_id=info:doi/10.4103%2F0019-5545.44909 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2009-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epilepsia. 2008 Dec;49(12):2122-4 [18557775] J Clin Psychiatry. 2002;63 Suppl 4:56-62 [11913677] Neurology. 2008 Jul 22;71(4):272-6 [18645165] Reprod Toxicol. 2008 Apr;25(3):388-9 [18424066] J Psychopharmacol. 2008 Mar;22(2 Suppl):70-5 [18477623] CNS Drugs. 2008;22(4):325-34 [18336060] J Clin Psychopharmacol. 2007 Dec;27(6):639-61 [18004132] Am J Psychiatry. 2007 Sep;164(9):1404-10 [17728426] Eur J Neurol. 2006 Jun;13(6):645-54 [16796590] J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):193-8 [16157661] Neurology. 2005 Mar 22;64(6):961-5 [15781808] Neurology. 2005 Mar 22;64(6):955-60 [15781807] Neurology. 2005 Mar 22;64(6):949-54 [15781806] J Clin Endocrinol Metab. 1977 May;44(5):989-93 [558225] Am J Psychiatry. 2004 Apr;161(4):608-20 [15056503] J Clin Psychiatry. 2008 May;69(5):817-29 [18466043] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4103/0019-5545.44909 ER - TY - JOUR T1 - Fetal alcohol spectrum disorders: when science, medicine, public policy, and laws collide. AN - 734038859; 19731390 AB - Historically, alcohol has been used for different purposes including as a part of religious observances, as a food, at times as a medicine and its well-known use as a beverage. Until relatively recently these purposes have not changed and have at times been at odds with one another, resulting in collisions among policies and practices in science, medicine, public policy and the law. One area in which this has been particularly true is that of fetal alcohol spectrum disorders (FASD) where the adverse consequences of consumed alcohol on children in the womb and after birth may have been observed since antiquity, but the actions taken based on such observations have been influenced as much by the socio/cultural/political context of the times in which they were made as by evidence of harm. This article provides an overview of the inherent confusion when new scientific findings confront prevailing medical practice, the history involved in this confusion with respect to FASD, including public policy and legal issues that have arisen around alcohol and pregnancy, and the research and clinical challenges still being faced. (c) 2009 Wiley-Liss, Inc. JF - Developmental disabilities research reviews AU - Warren, Kenneth R AU - Hewitt, Brenda G AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 170 EP - 175 VL - 15 IS - 3 KW - Index Medicus KW - United States KW - Infant KW - History, 21st Century KW - History, 20th Century KW - Humans KW - History, 18th Century KW - Infant, Newborn KW - History, 19th Century KW - Female KW - Pregnancy KW - Alcoholism -- history KW - Public Policy -- history KW - Fetal Alcohol Spectrum Disorders -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734038859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+disabilities+research+reviews&rft.atitle=Fetal+alcohol+spectrum+disorders%3A+when+science%2C+medicine%2C+public+policy%2C+and+laws+collide.&rft.au=Warren%2C+Kenneth+R%3BHewitt%2C+Brenda+G&rft.aulast=Warren&rft.aufirst=Kenneth&rft.date=2009-01-01&rft.volume=15&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Developmental+disabilities+research+reviews&rft.issn=1940-5529&rft_id=info:doi/10.1002%2Fddrr.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2009-09-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ddrr.71 ER - TY - JOUR T1 - Recombinant immunotoxins for the treatment of chemoresistant hematologic malignancies. AN - 733970328; 19689336 AB - Recombinant immunotoxins are proteins composed of fragments of monoclonal antibodies fused to truncated protein toxins. No agents of this class are approved yet for medical use, although a related molecule, denileukin diftitox, composed of interleukin-2 fused to truncated diphtheria toxin, is approved for relapsed/refractory cutaneous T-cell lymphoma. Recombinant immunotoxins which have been tested in patients with chemotherapy-pretreated hematologic malignancies include LMB-2 (anti-CD25), BL22 (CAT-3888, anti-CD22) and HA22 (CAT-8015, anti-CD22), each containing an Fv fragment fused to truncated Pseudomonas exotoxin. Major responses were observed with LMB-2 in adult T-cell leukemia, chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma, Hodgkin's disease, and hairy cell leukemia (HCL). BL22 resulted in a high complete remission rate in patients with HCL, particularly those without excessive tumor burden. HA22, an improved version of BL22 with higher affinity to CD22, is now undergoing phase I testing in HCL, CLL, non-Hodgkin's lymphoma, and pediatric acute lymphoblastic leukemia. JF - Current pharmaceutical design AU - Kreitman, Robert J AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, 37/5124b, 9000 Rockville Pike, Bethesda, MD 20892, USA. kreitmar@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 2652 EP - 2664 VL - 15 IS - 23 KW - Diphtheria Toxin KW - 0 KW - Immunotoxins KW - Leukocidins KW - Pseudomonas aeruginosa Cytotoxins KW - Recombinant Proteins KW - Toxins, Biological KW - Index Medicus KW - Leukocidins -- pharmacology KW - Humans KW - Toxins, Biological -- pharmacology KW - Diphtheria Toxin -- pharmacology KW - Clinical Trials as Topic KW - Models, Biological KW - Recombinant Proteins -- biosynthesis KW - Hematologic Neoplasms -- drug therapy KW - Immunotoxins -- therapeutic use KW - Drug Resistance, Neoplasm -- immunology KW - Recombinant Proteins -- therapeutic use KW - Drug Discovery -- methods KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733970328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+design&rft.atitle=Recombinant+immunotoxins+for+the+treatment+of+chemoresistant+hematologic+malignancies.&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=15&rft.issue=23&rft.spage=2652&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+design&rft.issn=1873-4286&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-21 N1 - Date created - 2009-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amphetamine recapitulates developmental programs in the zebrafish. AN - 733943056; 19664194 AB - Addictive drugs hijack the human brain's 'reward' systems. A zebrafish model of addiction has recently been used to query changes in gene expression during this process. JF - Genome biology AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse/IRP, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA. jcadet@intra.nida.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 231 VL - 10 IS - 7 KW - Central Nervous System Stimulants KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Animals KW - Reward KW - Central Nervous System Stimulants -- toxicity KW - Signal Transduction -- drug effects KW - Conditioning, Classical -- drug effects KW - Models, Biological KW - Behavior, Addictive -- genetics KW - Transcription, Genetic -- drug effects KW - Amphetamine -- toxicity KW - Transcription, Genetic -- genetics KW - Zebrafish -- physiology KW - Zebrafish -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733943056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+biology&rft.atitle=Amphetamine+recapitulates+developmental+programs+in+the+zebrafish.&rft.au=Cadet%2C+Jean+Lud&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2009-01-01&rft.volume=10&rft.issue=7&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Genome+biology&rft.issn=1474-760X&rft_id=info:doi/10.1186%2Fgb-2009-10-7-231 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-13 N1 - Date created - 2009-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Brain Behav. 2004 Apr;3(2):63-74 [15005714] Neuropharmacology. 2004;47 Suppl 1:33-46 [15464124] Nature. 1981 May 28;291(5813):293-6 [7248006] Prog Neurobiol. 1994 Dec;44(5):497-516 [7886237] Development. 1996 Dec;123:1-36 [9007226] Can J Psychol. 1957 Jun;11(2):104-12 [13426853] Addict Biol. 2005 Mar;10(1):101-18 [15849024] Lab Anim (NY). 2006 May;35(5):33-9 [16645614] Methods. 2006 Jul;39(3):262-74 [16809048] Addict Biol. 2007 Sep;12(3-4):227-462 [17678505] J Clin Invest. 2008 Feb;118(2):454-61 [18246196] Genes Brain Behav. 2008 Mar;7(2):193-202 [17640290] Biochim Biophys Acta. 2008 Aug;1779(8):432-7 [18674649] Neuropharmacology. 2009;56 Suppl 1:73-82 [18647613] Biol Lett. 2009 Feb 23;5(1):112-6 [18755655] Brain Res Rev. 2009 Mar;59(2):253-77 [18762212] Neuron. 2009 May 14;62(3):335-48 [19447090] Genome Biol. 2009;10(7):R81 [19646228] Comment On: Genome Biol. 2009;10(7):R81 [19646228] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/gb-2009-10-7-231 ER - TY - JOUR T1 - Vascular endothelial barrier dysfunction mediated by amyloid-beta proteins. AN - 733867900; 19542618 AB - Neuronal inflammation is very common in Alzheimer's disease (AD). This inflammation can be caused by infiltration of neutrophils across the blood brain barrier. Endothelial permeability changes are required for the infiltration of high molecular weight components to the brain. Deposition of toxic amyloid-beta (A beta) fibrils in the cerebral vasculature, as well as in brain neurons, has been implicated in the development of AD. This study investigates the effect of A beta fibrils on the permeability of the endothelium and the mechanism for the observed permeability changes. A beta(1-40) and A beta(1-42) fibrils, but not monomers, were found to increase permeability of bovine pulmonary arterial endothelial cells in a dose- and time dependent manner as detected by transendothelial electrical resistance. This increase in permeability is only partially (25%) inhibited by catalase and is not associated with an increase in cytosolic Ca+2 or tyrosine phosphorylation. These results indicate that hydrogen peroxide is not the primary mediator for the permeability changes. Treatment of cells with both amyloid fibrils resulted in stress fiber formation, disruption and aggregation of actin filaments, and cellular gap formation. The results of this study reveal that A beta increases the permeability of endothelium by inducing change in the cytoskeleton network. JF - Journal of Alzheimer's disease : JAD AU - Nagababu, Enika AU - Usatyuk, Peter V AU - Enika, Divya AU - Natarajan, Viswanathan AU - Rifkind, Joseph M AD - Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 845 EP - 854 VL - 17 IS - 4 KW - Amyloid beta-Peptides KW - 0 KW - Cytoskeletal Proteins KW - Organophosphates KW - Polymers KW - tyrosine polyphosphate KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Microscopy, Fluorescence KW - Calcium -- metabolism KW - Animals KW - Cattle KW - Blotting, Western KW - Organophosphates -- metabolism KW - Cells, Cultured KW - Electric Impedance KW - Polymers -- metabolism KW - Pulmonary Artery -- cytology KW - Cytoskeletal Proteins -- metabolism KW - Time Factors KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- cytology KW - Amyloid beta-Peptides -- metabolism KW - Cell Membrane Permeability -- drug effects KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733867900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.atitle=Vascular+endothelial+barrier+dysfunction+mediated+by+amyloid-beta+proteins.&rft.au=Nagababu%2C+Enika%3BUsatyuk%2C+Peter+V%3BEnika%2C+Divya%3BNatarajan%2C+Viswanathan%3BRifkind%2C+Joseph+M&rft.aulast=Nagababu&rft.aufirst=Enika&rft.date=2009-01-01&rft.volume=17&rft.issue=4&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.issn=1875-8908&rft_id=info:doi/10.3233%2FJAD-2009-1104 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-22 N1 - Date created - 2010-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2007 May 23;27(21):5719-29 [17522316] Curr Alzheimer Res. 2007 Apr;4(2):191-7 [17430246] J Neurochem. 2008 Jan;104(2):500-13 [17953673] Brain Pathol. 2008 Apr;18(2):253-66 [18363936] Ann N Y Acad Sci. 2008 Mar;1123:134-45 [18375586] Neurobiol Aging. 2000 May-Jun;21(3):383-421 [10858586] J Struct Biol. 2000 Jun;130(2-3):184-208 [10940225] Am J Physiol Cell Physiol. 2000 Dec;279(6):C1772-81 [11078691] Am J Physiol Cell Physiol. 2001 Apr;280(4):C719-41 [11245588] J Cereb Blood Flow Metab. 2001 Jun;21(6):702-10 [11488539] Microcirculation. 2001 Aug;8(4):207-20 [11528529] J Appl Physiol (1985). 2001 Oct;91(4):1487-500 [11568129] Am J Physiol Cell Physiol. 2001 Dec;281(6):C1940-7 [11698252] Stroke. 2002 Apr;33(4):1152-62 [11935076] Free Radic Biol Med. 2002 Jun 1;32(11):1050-60 [12031889] J Neural Transm (Vienna). 2002 May;109(5-6):813-36 [12111471] Am J Physiol Cell Physiol. 2002 Sep;283(3):C895-904 [12176746] Surgery. 2002 Aug;132(2):180-5 [12219009] Acta Histochem. 2003;105(2):115-25 [12831163] Brain Res Brain Res Rev. 2003 Oct;43(2):207-23 [14572915] Antioxid Redox Signal. 2003 Dec;5(6):723-30 [14588145] J Alzheimers Dis. 2003 Aug;5(4):275-86 [14624023] Endothelium. 2003;10(6):309-17 [14741846] Microcirculation. 2003 Dec;10(6):463-70 [14745459] J Biol Chem. 2004 Mar 19;279(12):11789-97 [14699126] Int J Biochem Cell Biol. 2005 Feb;37(2):289-305 [15474976] Nature. 1987 Feb 19-25;325(6106):733-6 [2881207] Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7919-23 [1518814] Nature. 1992 Sep 24;359(6393):325-7 [1406936] Cell. 1994 Jun 17;77(6):817-27 [8004671] Neuron. 1996 May;16(5):921-32 [8630250] Neurosci Lett. 1996 Mar 15;206(2-3):157-60 [8710175] Am J Physiol. 1996 Jun;270(6 Pt 1):L973-8 [8764222] Nat Med. 1996 Aug;2(8):864-70 [8705854] Acta Neuropathol. 1996;91(1):6-14 [8773140] Am J Physiol. 1996 Feb;270(2 Pt 1):G363-9 [8779980] Life Sci. 1996;59(18):1483-97 [8890929] J Neurosci Res. 1997 Jan 15;47(2):216-23 [9008152] Free Radic Biol Med. 1997;23(1):134-47 [9165306] Am J Physiol. 1997 Jul;273(1 Pt 1):L31-9 [9252537] Am J Physiol. 1997 Jul;273(1 Pt 1):L172-84 [9252554] Ann N Y Acad Sci. 1997 Sep 26;826:161-72 [9329688] Neurosci Lett. 1998 Sep 4;253(2):139-41 [9774169] Am J Physiol. 1999 Jul;277(1 Pt 1):L150-8 [10409242] J Neurosci. 2005 Feb 2;25(5):1149-58 [15689551] Am J Pathol. 2005 Apr;166(4):955-7 [15793276] Int J Mol Med. 2005 Jun;15(6):929-35 [15870895] Cardiovasc Res. 2005 Oct 1;68(1):26-36 [16009356] Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L999-1010 [16040628] FASEB J. 2006 Mar;20(3):426-33 [16507760] Biochim Biophys Acta. 2007 Aug;1768(8):1976-90 [17433250] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3233/JAD-2009-1104 ER - TY - JOUR T1 - Truncation of histone H2A's C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects. AN - 733576900; 19667409 AB - Nickel(II), capable of transforming cells and causing tumors in humans and animals, has been previously shown by us to mediate hydrolytic truncation of histone H2A's C-terminal tail by 8 amino acids in both cell-free and cell culture systems. Since H2A's C-tail is involved in maintaining chromatin structure, such truncation might alter this structure and affect gene expression. To test the latter possibility, we transfected cultured T-REx 293 human embryonic kidney cells with plasmids expressing either wild type (wt) or truncated (q) histone H2A proteins, which were either untagged or N-terminally tagged with fluorescent proteins. Each histone variant was found to be incorporated into chromatin at 24 and 48 hr post-transfection. Cells transfected with the untagged plasmids were tested for gene expression by microarray and real-time PCR. Evaluation of the results for over 21,000 genes using the multidimensional scaling and hierarchical clustering methods revealed significant differences in expression of numerous genes between the q-H2A and wt-H2A transfectants. Many of the differentially expressed genes, including BAZ2A, CLDN18, CYP51A1, GFR, GIPC2, HMGB1, IRF7, JAK3, PSIP1, and VEGF, are cancer-related genes. The results thus demonstrate the potential of q-H2A to contribute to the process of carcinogenesis through epigenetic mechanisms. JF - Annals of clinical and laboratory science AU - Karaczyn, Aldona A AU - Cheng, Robert Y S AU - Buzard, Gregory S AU - Hartley, James AU - Esposito, Dominic AU - Kasprzak, Kazimierz S AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 251 EP - 262 VL - 39 IS - 3 KW - Histones KW - 0 KW - Recombinant Fusion Proteins KW - Nickel KW - 7OV03QG267 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Up-Regulation -- genetics KW - Amino Acid Sequence KW - Hydrolysis KW - Recombinant Fusion Proteins -- metabolism KW - Gene Expression Profiling KW - Polymerase Chain Reaction KW - Down-Regulation -- genetics KW - Transfection KW - Recombinant Fusion Proteins -- genetics KW - Time Factors KW - Cluster Analysis KW - Cell Line KW - Neoplasms -- etiology KW - Histones -- metabolism KW - Histones -- chemistry KW - Nickel -- metabolism KW - Gene Expression Regulation KW - Histones -- genetics KW - Sequence Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733576900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+and+laboratory+science&rft.atitle=Truncation+of+histone+H2A%27s+C-terminal+tail%2C+as+is+typical+for+Ni%28II%29-assisted+specific+peptide+bond+hydrolysis%2C+has+gene+expression+altering+effects.&rft.au=Karaczyn%2C+Aldona+A%3BCheng%2C+Robert+Y+S%3BBuzard%2C+Gregory+S%3BHartley%2C+James%3BEsposito%2C+Dominic%3BKasprzak%2C+Kazimierz+S&rft.aulast=Karaczyn&rft.aufirst=Aldona&rft.date=2009-01-01&rft.volume=39&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+and+laboratory+science&rft.issn=1550-8080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 1999 May 19;258(3):592-5 [10329430] Br J Haematol. 2006 May;133(3):270-5 [16643428] Biochim Biophys Acta. 2006 Apr;1765(2):148-54 [16386852] Int J Hematol. 2006 Apr;83(3):195-200 [16720547] Expert Rev Mol Med. 2006;8(18):1-11 [16887048] BMC Cancer. 2006;6:186 [16836752] Leukemia. 2006 Oct;20(10):1759-66 [16932349] Int J Biochem Cell Biol. 2007;39(1):171-80 [16979371] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16236-41 [17060627] Mol Cell Biol. 2007 Apr;27(7):2661-75 [17283066] Cancer Res. 2007 Mar 15;67(6):2559-67 [17363574] Cancer Sci. 2007 Jan;98(1):77-82 [17083565] Am J Surg Pathol. 2008 Feb;32(2):188-96 [18223320] Oncogene. 2008 Feb 28;27(10):1404-11 [17828303] Oncogene. 2008 Mar 6;27(11):1511-9 [17873904] Arch Med Res. 2008 May;39(4):365-72 [18375246] Acta Biochim Biophys Sin (Shanghai). 2008 Apr;40(4):297-303 [18401527] Breast J. 2008 May-Jun;14(3):261-7 [18373644] Curr Cancer Drug Targets. 2008 Jun;8(4):253-65 [18537549] J Histochem Cytochem. 2008 Aug;56(8):711-21 [18474937] Mol Med. 2008 Jul-Aug;14(7-8):476-84 [18431461] Cancer Biol Ther. 2008 Jul;7(7):1098-103 [18443431] Biochim Biophys Acta. 2008 Dec;1786(2):178-87 [18541156] Genes Chromosomes Cancer. 1999 Sep;26(1):62-9 [10441007] Cell. 1999 Aug 6;98(3):285-94 [10458604] J Virol. 2004 Dec;78(23):12987-95 [15542650] Front Biosci. 2005 Jan 1;10:866-72 [15569624] Clin Cancer Res. 2005 Jan 1;11(1):226-31 [15671550] Genes Dev. 2005 Feb 1;19(3):295-310 [15687254] Environ Health Perspect. 2005 May;113(5):577-84 [15866766] Clin Cancer Res. 2005 May 15;11(10):3758-65 [15897573] Immunology. 2005 Jul;115(3):358-65 [15946253] J Clin Invest. 2005 Jul;115(7):1765-76 [15965503] Clin Cancer Res. 2005 Oct 15;11(20):7369-75 [16243809] Clin Cancer Res. 2006 Jan 15;12(2):353-60 [16428472] J Pathol. 2006 Apr;208(5):633-42 [16435283] J Hum Genet. 2006;51(4):368-74 [16435073] Genomics. 2000 Jan 1;63(1):40-5 [10662543] Cancer Res. 2000 Mar 15;60(6):1521-5 [10749116] Hum Mol Genet. 2000 Mar 22;9(5):757-63 [10749982] Chem Res Toxicol. 2000 Jul;13(7):616-24 [10898594] Nucleic Acids Res. 2000 Sep 15;28(18):3478-85 [10982866] J Biol Chem. 2000 Nov 10;275(45):34901-8 [10934204] Genome Res. 2000 Nov;10(11):1788-95 [11076863] Radiat Res. 2001 Jan;155(1 Pt 2):181-187 [11121232] Genomics. 2001 Apr 15;73(2):211-22 [11318611] J Biol Chem. 2001 May 25;276(21):18624-32 [11278666] J Biol Chem. 2001 Feb 16;276(7):5074-84 [11085978] Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6599-604 [11381129] Biochem Biophys Res Commun. 2001 Jun 22;284(4):1083-9 [11409905] Biochim Biophys Acta. 2001 Dec 3;1522(2):118-21 [11750063] J Neural Transm Suppl. 2001;(61):95-107 [11771764] Biochem Cell Biol. 2001;79(6):693-708 [11800010] Int J Oncol. 2002 Mar;20(3):571-6 [11836570] J Interferon Cytokine Res. 2002 Jan;22(1):95-101 [11846980] Biochemistry. 2002 May 14;41(19):5945-9 [11993987] Int J Mol Med. 2002 Jun;9(6):585-9 [12011974] Int J Oncol. 2002 Jun;20(6):1183-7 [12011997] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7877-82 [12060735] Biochim Biophys Acta. 2002 Nov 4;1600(1-2):68-73 [12445461] Biochemistry. 2002 Dec 17;41(50):14960-8 [12475245] Mol Carcinog. 2002 Dec;35(4):186-95 [12489110] Am J Pathol. 2003 Jul;163(1):81-9 [12819013] Cancer Metastasis Rev. 2003 Dec;22(4):423-34 [12884916] Toxicol Appl Pharmacol. 2003 Aug 15;191(1):22-39 [12915101] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13225-30 [14578449] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13118-20 [14597707] Brain Res Mol Brain Res. 2003 Nov 26;119(2):216-9 [14625090] Genes Dev. 2003 Nov 15;17(22):2733-40 [14630937] J Cancer Res Clin Oncol. 2003 Dec;129(12):735-6 [14574570] Mutat Res. 2003 Dec 10;533(1-2):67-97 [14643413] Chem Res Toxicol. 2003 Dec;16(12):1555-9 [14680369] J Neurosci. 2004 Feb 18;24(7):1707-18 [14973233] Int J Oncol. 2004 Apr;24(4):1033-8 [15010845] J Invest Dermatol. 2004 May;122(5):1180-7 [15140221] Int J Oncol. 2004 Oct;25(4):821-30 [15375529] Biochim Biophys Acta. 1968 Aug 27;167(1):154-60 [4176710] Biochemistry. 1974 Dec 3;13(25):5128-34 [4373030] Cell. 1976 Dec;9(4 PT 2):785-92 [13934] Eur J Biochem. 1980 Aug;109(1):17-23 [7408874] Nucleic Acids Res. 1983 May 11;11(9):2681-700 [6406983] Ann Clin Lab Sci. 1984 Sep-Oct;14(5):355-65 [6236739] J Biol Chem. 1988 Dec 15;263(35):18972-8 [3058692] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6845-9 [8041707] Exp Cell Res. 1994 Nov;215(1):63-7 [7957682] Int J Cancer. 1998 Jun 10;76(6):903-8 [9626360] Chem Res Toxicol. 1998 Sep;11(9):1014-23 [9760275] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evolving views of DNA replication (in)fidelity. AN - 733372920; 19903750 AB - "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material" (Watson and Crick 1953). In the years since this remarkable understatement, we have come to realize the enormous complexity of the cellular machinery devoted to replicating DNA with the accuracy needed to maintain genetic information over many generations, balanced by the emergence of mutations on which selection can act. This complexity is partly based on the need to remove or tolerate cytotoxic and mutagenic lesions in DNA generated by environmental stress. Considered here is the fidelity with which undamaged and damaged DNA is replicated by the many DNA polymerases now known to exist. Some of these seriously violate Watson-Crick base-pairing rules such that, depending on the polymerase, the composition and location of the error, and the ability to correct errors (or not), DNA synthesis error rates can vary by more than a millionfold. This offers the potential to modulate rates of point mutations over a wide range, with consequences that can be either deleterious or beneficial. JF - Cold Spring Harbor symposia on quantitative biology AU - Kunkel, T A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. kunkel@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 91 EP - 101 VL - 74 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Escherichia coli -- metabolism KW - DNA Repair KW - Models, Molecular KW - Humans KW - Escherichia coli -- genetics KW - Models, Biological KW - DNA-Directed DNA Polymerase -- chemistry KW - INDEL Mutation KW - DNA Mismatch Repair KW - Genomic Instability KW - Mutation KW - DNA-Directed DNA Polymerase -- genetics KW - Protein Conformation KW - DNA-Directed DNA Polymerase -- metabolism KW - DNA Replication -- genetics KW - DNA Replication -- physiology KW - Evolution, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733372920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.atitle=Evolving+views+of+DNA+replication+%28in%29fidelity.&rft.au=Kunkel%2C+T+A&rft.aulast=Kunkel&rft.aufirst=T&rft.date=2009-01-01&rft.volume=74&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.issn=1943-4456&rft_id=info:doi/10.1101%2Fsqb.2009.74.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-12 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2002 Aug 1;16(15):1872-83 [12154119] Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7160-4 [1831267] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] Biochimie. 1975;57(5):587-95 [1182215] J Mol Biol. 1982 Mar 25;156(1):37-51 [6212689] Annu Rev Biochem. 1982;51:429-57 [6214209] Nature. 1985 Feb 28-Mar 6;313(6005):762-6 [3883192] Mol Gen Genet. 1994 Feb;242(3):289-96 [8107676] J Biol Chem. 1995 Jan 13;270(2):746-50 [7822305] Genetics. 1994 Nov;138(3):553-64 [7851754] Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10144-9 [9294177] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5 [9618505] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10020-5 [9707593] Ann N Y Acad Sci. 1999 May 18;870:100-7 [10415476] Nature. 1953 Apr 25;171(4356):737-8 [13054692] Biochim Biophys Acta. 1956 Jul;21(1):197-8 [13363894] Adv Protein Chem. 2004;69:229-64 [15588845] DNA Repair (Amst). 2003 Feb 3;2(2):135-49 [12531385] Curr Biol. 2003 Apr 29;13(9):744-8 [12725731] Structure. 2003 May;11(5):489-96 [12737815] Cold Spring Harb Symp Quant Biol. 2000;65:81-91 [12760023] Nat Genet. 2003 Jul;34(3):326-9 [12796780] Sci Aging Knowledge Environ. 2003 Feb 26;2003(8):RE3 [12844548] J Biol Chem. 2003 Oct 31;278(44):43770-80 [12882968] Mol Cell Biol. 2005 Jan;25(1):461-71 [15601866] Trends Immunol. 2005 Apr;26(4):215-20 [15797512] Mol Cell. 2005 May 27;18(5):499-505 [15916957] Annu Rev Biochem. 2005;74:681-710 [15952900] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15803-8 [16249340] Curr Biol. 2006 Jan 24;16(2):202-7 [16431373] Chem Rev. 2006 Feb;106(2):302-23 [16464007] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] Cell Cycle. 2006 May;5(9):958-62 [16687920] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18083-8 [17114294] Nat Struct Mol Biol. 2007 Jan;14(1):45-53 [17159995] Science. 2007 Jul 6;317(5834):127-30 [17615360] Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15591-8 [17898175] DNA Repair (Amst). 2007 Dec 1;6(12):1829-38 [17715002] Mol Cell. 2007 Nov 30;28(4):522-9 [18042449] Cell Res. 2008 Jan;18(1):148-61 [18166979] Mol Cell. 2008 Apr 25;30(2):137-44 [18439893] Mech Ageing Dev. 2008 Jul-Aug;129(7-8):391-407 [18406444] Nat Rev Genet. 2008 Aug;9(8):594-604 [18626473] J Mol Biol. 2008 Oct 17;382(4):859-69 [18691598] Trends Cell Biol. 2008 Nov;18(11):521-7 [18824354] Nat Chem Biol. 2009 Feb;5(2):82-90 [19148176] J Biol Chem. 2009 Feb 13;284(7):4041-5 [18835809] Nucleic Acids Res. 2009 Jun;37(11):3774-87 [19380376] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13910-3 [10570172] Annu Rev Biochem. 2000;69:497-529 [10966467] Mol Cell Biol. 2001 Feb;21(3):940-51 [11154280] Science. 2001 Mar 16;291(5511):2156-9 [11251121] Nat Med. 2001 Jun;7(6):638-9 [11385474] Cell. 2001 Jun 1;105(5):657-67 [11389835] Mol Cell. 2001 Jul;8(1):7-8 [11515498] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] Annu Rev Biochem. 2002;71:191-219 [12045095] EMBO J. 1989 Nov;8(11):3511-6 [2555167] Biochemistry. 1991 Jan 15;30(2):538-46 [1988042] DNA Repair (Amst). 2002 Jun 21;1(6):425-35 [12509231] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1101/sqb.2009.74.027 ER - TY - JOUR T1 - The development of gene therapy: from monogenic recessive disorders to complex diseases such as cancer. AN - 67439445; 19565894 AB - During the last 4 decades, gene therapy has moved from preclinical to clinical studies for many diseases ranging from monogenic recessive disorders such as hemophilia to more complex diseases such as cancer, cardiovascular disorders, and human immunodeficiency virus (HIV). To date, more than 1,340 gene therapy clinical trials have been completed, are ongoing, or have been approved in 28 countries, using more than 100 genes. Most of those clinical trials (66.5%) were aimed at the treatment of cancer. Early hype, failures, and tragic events have now largely been replaced by the necessary stepwise progress needed to realize clinical benefits. We now understand better the strengths and weaknesses of various gene transfer vectors; this facilitates the choice of appropriate vectors for individual diseases. Continuous advances in our understanding of tumor biology have allowed the development of elegant, more efficient, and less toxic treatment strategies. In this introductory chapter, we review the history of gene therapy since the early 1960s and present in detail two major recurring themes in gene therapy: (1) the development of vector and delivery systems and (2) the design of strategies to fight or cure particular diseases. The field of cancer gene therapy experienced an "awkward adolescence." Although this field has certainly not yet reached maturity, it still holds the potential of alleviating the suffering of many individuals with cancer. JF - Methods in molecular biology (Clifton, N.J.) AU - Gillet, Jean-Pierre AU - Macadangdang, Benjamin AU - Fathke, Robert L AU - Gottesman, Michael M AU - Kimchi-Sarfaty, Chava AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 5 EP - 54 VL - 542 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - History, 21st Century KW - History, 20th Century KW - Gene Transfer Techniques KW - Humans KW - Genetic Vectors KW - Genetic Therapy -- history KW - Neoplasms -- therapy KW - Neoplasms -- genetics KW - Genes, Recessive UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67439445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=The+development+of+gene+therapy%3A+from+monogenic+recessive+disorders+to+complex+diseases+such+as+cancer.&rft.au=Gillet%2C+Jean-Pierre%3BMacadangdang%2C+Benjamin%3BFathke%2C+Robert+L%3BGottesman%2C+Michael+M%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Gillet&rft.aufirst=Jean-Pierre&rft.date=2009-01-01&rft.volume=542&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-561-9_1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-561-9_1 ER - TY - JOUR T1 - Airway inflammation and upregulation of beta2 Mac-1 integrin expression on circulating leukocytes of female ragpickers in India. AN - 67390912; 19372628 AB - Over one million ragpickers collect and sale recyclable materials from municipal solid wastes (MSW) in India for a living. Since MSW contains a host of pathogenic microorganisms, we investigated the occurrence of airway inflammation and its underlying mechanism in 52 non-smoking female ragpickers (median age 29 yr) and 42 control women matched for age, smoking habit and socioeconomic conditions in Kolkata, eastern India. Spontaneously expectorated sputum were stained using the Papanicolau method for cytology, and flow cytometry was used for measurements of surface expression of beta(2) Mac-1 integrin (CD11b/CD18) on leukocytes and P-selectin on platelets. The concentrations of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and chemokine interleukin-8 (IL-8) were measured in plasma by enzyme-linked immunosorbent assay. Compared with controls, sputum samples of ragpickers contained significantly increased numbers of alveolar macrophages, neutrophils, eosinophils and lymphocytes, suggesting airway inflammation. Circulating neutrophils and monocytes of the ragpickers overexpressed CD11b/CD18 and their platelets had upregulated surface expression of P-selectin, implying functional activation of these cells. In addition, plasma levels of IL-8 and TNF-alpha were significantly increased, indicating greater trafficking of leukocytes from circulation to the tissues. Multivariate logistic regression analysis demonstrated a positive association between the ragpicking profession and leukocyte activation after controlling for potential confounders. Ragpickers experience leukocyte and platelet activation and airway inflammation that could make them more vulnerable to tissue damage and cardiovascular diseases. JF - Journal of occupational health AU - Ray, Manas Ranjan AU - Roychoudhury, Sanghita AU - Mukherjee, Sayali AU - Siddique, Shabana AU - Banerjee, Madhuchanda AU - Akolkar, A B AU - Sengupta, B AU - Lahiri, Twisha AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata, India. manasrray@rediffmail.com Y1 - 2009 PY - 2009 DA - 2009 SP - 232 EP - 238 VL - 51 IS - 3 KW - Macrophage-1 Antigen KW - 0 KW - P-Selectin KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Poverty KW - P-Selectin -- blood KW - Humans KW - Adult KW - Tumor Necrosis Factor-alpha -- blood KW - P-Selectin -- metabolism KW - Middle Aged KW - Garbage KW - Tumor Necrosis Factor-alpha -- metabolism KW - Female KW - India KW - Leukocytes -- metabolism KW - Macrophage-1 Antigen -- metabolism KW - Bronchitis -- etiology KW - Macrophage-1 Antigen -- blood KW - Bronchitis -- physiopathology KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67390912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+health&rft.atitle=Airway+inflammation+and+upregulation+of+beta2+Mac-1+integrin+expression+on+circulating+leukocytes+of+female+ragpickers+in+India.&rft.au=Ray%2C+Manas+Ranjan%3BRoychoudhury%2C+Sanghita%3BMukherjee%2C+Sayali%3BSiddique%2C+Shabana%3BBanerjee%2C+Madhuchanda%3BAkolkar%2C+A+B%3BSengupta%2C+B%3BLahiri%2C+Twisha&rft.aulast=Ray&rft.aufirst=Manas&rft.date=2009-01-01&rft.volume=51&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+health&rft.issn=1348-9585&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-22 N1 - Date created - 2009-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Rhinacanthus nasutus kurz on colon carcinogenesis in mice. AN - 67279193; 19469634 AB - Rhinacanthus nasutus Kurz, a Thai medicinal plant which possess antiproliferative and pro-apoptotic effects on human cancer cells, was examined for chemopreventive potential against colonic neoplasms induced by azoxymethane (AOM) combined with dextran sodium sulfate (DSS) in mice. Male ICR mice were given a single intraperitoneal administration of AOM (10 mg/kg body weight) followed by 2% DSS in their drinking water for a week. Water extract of the roots of R. nasutus (RNR) was given to the animals intragastrically daily in the initiation and promotion phases. The one hundred mice were divided into 8 groups, one group treated with AOM plus DSS serving as a control. Four other groups received AOM/DSS and RNR at 100 or 500 mg/kg body weight for 5 weeks (initiation phase study) and for 14 weeks (promotion phase study). Another two groups were given RNR alone at 100 and 500 mg/kg body weight and the last group was maintained untreated. At the end of the study, we found that the incidence and multiplicity of colonic tumors in mice fed with RNR both at 100 and 500 mg/kg body weight in initiation phase were higher than those in the control group. Moreover, RNR feeding during the promotion phase also gave similar results. Our results suggest that water extract of the roots of R. nasutus Kurz. has no preventive potential against colon carcinogenesis induced by AOM/DSS in mice, rather increasing the incidence of colonic tumors when given during initiation and promotion phases. Further study on RNR should provide more information on mechanisms of its tumor promotion activity. JF - Asian Pacific journal of cancer prevention : APJCP AU - Kupradinun, Piengchai AU - Siripong, Pongpun AU - Chanpai, Rittichai AU - Piyaviriyagul, Suratsawadee AU - Rungsipipat, Anudep AU - Wangnaitham, Supradit AD - National Cancer Institute, Bangkok, Thailand. pkupradi@health.moph.go.th PY - 2009 SP - 103 EP - 106 VL - 10 IS - 1 SN - 1513-7368, 1513-7368 KW - Carcinogens KW - 0 KW - Plant Extracts KW - Dextran Sulfate KW - 9042-14-2 KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Thailand KW - Mice KW - Male KW - Plant Extracts -- pharmacology KW - Plant Roots KW - Plants, Medicinal KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- chemically induced KW - Acanthaceae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67279193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Effects+of+Rhinacanthus+nasutus+kurz+on+colon+carcinogenesis+in+mice.&rft.au=Kupradinun%2C+Piengchai%3BSiripong%2C+Pongpun%3BChanpai%2C+Rittichai%3BPiyaviriyagul%2C+Suratsawadee%3BRungsipipat%2C+Anudep%3BWangnaitham%2C+Supradit&rft.aulast=Kupradinun&rft.aufirst=Piengchai&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.issn=1179-190X&rft_id=info:doi/10.2165%2F00063030-200923010-00001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-26 N1 - Date created - 2009-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neem (Azadirachta indica) leaf preparation prevents leukocyte apoptosis mediated by cisplatin plus 5-fluorouracil treatment in Swiss mice. AN - 67248675; 19346744 AB - Neem (Azadirachta indica) is widely regarded as a wonder tree because of its diverse medicinal applications. We investigated the ability of neem leaf preparation (NLP) to protect against apoptosis of circulating blood cells induced by cisplatin and 5-fluorouracil (cis + 5-FU) in carcinoma-bearing mice. Apoptosis was studied by annexin V-propidium iodide method. Total white blood cell count was performed using 3% glacial acetic acid on hemocytometer. Cytotoxicity was determined by LDH release assay and T/NK cell status was determined by flow cytometry. In comparison to untreated control, during cis + 5-FU therapy, significant down-regulation of leukocyte apoptosis was noted in mice pretreated with NLP or granulocyte colony stimulating factor (GCSF) during cis + 5-FU therapy. This enhanced cytotoxicity may be associated with NLP-induced increase of the cytotoxic T and NK cell pool. Efficacy of NLP is comparable to GCSF in its ability to protect against leukocyte apoptosis induced by cis + 5-FU. NLP would be a better choice of treatment because GCSF is tumor promoting, angiogenic and expensive. Copyright 2009 S. Karger AG, Basel. JF - Chemotherapy AU - Ghosh, Diptendu AU - Bose, Anamika AU - Haque, Enamul AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2009 PY - 2009 DA - 2009 SP - 137 EP - 144 VL - 55 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Plant Extracts KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Animals KW - Mice KW - Plant Leaves -- chemistry KW - Granulocyte Colony-Stimulating Factor -- pharmacology KW - Fluorouracil -- therapeutic use KW - Plant Extracts -- pharmacology KW - Cisplatin -- therapeutic use KW - Apoptosis KW - Fluorouracil -- toxicity KW - Leukocytes -- physiology KW - Cisplatin -- toxicity KW - Antineoplastic Agents -- toxicity KW - Azadirachta -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Leukocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67248675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemotherapy&rft.atitle=Neem+%28Azadirachta+indica%29+leaf+preparation+prevents+leukocyte+apoptosis+mediated+by+cisplatin+plus+5-fluorouracil+treatment+in+Swiss+mice.&rft.au=Tarca%2C+Adi+Laurentiu%3BDraghici%2C+Sorin%3BKhatri%2C+Purvesh%3BHassan%2C+Sonia+S%3BMittal%2C+Pooja%3BKim%2C+Jung-sun%3BKim%2C+Chong+Jai%3BKusanovic%2C+Juan+Pedro%3BRomero%2C+Roberto&rft.aulast=Tarca&rft.aufirst=Adi&rft.date=2009-01-01&rft.volume=25&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn577 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000211558 ER - TY - JOUR T1 - Epidemiologic studies in agricultural populations: observations and future directions. AN - 67244568; 19437268 AB - This paper reviews epidemiologic studies of cancer among agricultural populations to identify possible associations and to provide a focus for future investigations. Meta-analyses of mortality surveys of farmers find excesses of several cancers, including connective tissue, non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma and cancers of the skin, stomach, and brain, and deficits for total mortality, heart disease, total cancer, and cancers of the esophagus, colon, lung, and bladder. Meta-analyses of studies of individual cancers also support these findings, indicating a need to identify exposures and lifestyle factors that might account for this mortality pattern. Although cancer studies of other occupations that might have pesticide exposures in common with farmers show some similarities with observations among farmers, the overall patterns are quite different. This suggests that pesticides are not likely to fully explain the cancer and other disease patterns observed among farmers. Because exposures vary by type of farm operation, exposures for individual farmers can differ considerably. Studies in the future need to focus on the full range of exposures to fully understand the cancer pattern in farmers. JF - Journal of agromedicine AU - Blair, Aaron AU - Freeman, Laura Beane AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA. blaira@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 125 EP - 131 VL - 14 IS - 2 KW - Agrochemicals KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Occupational Exposure -- adverse effects KW - Meta-Analysis as Topic KW - Agrochemicals -- adverse effects KW - Agriculture KW - Agricultural Workers' Diseases -- etiology KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- epidemiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67244568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Epidemiologic+studies+in+agricultural+populations%3A+observations+and+future+directions.&rft.au=Blair%2C+Aaron%3BFreeman%2C+Laura+Beane&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2009-01-01&rft.volume=14&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1545-0813&rft_id=info:doi/10.1080%2F10599240902779436 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-24 N1 - Date created - 2009-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Scand J Work Environ Health. 1999 Oct;25(5):436-41 [10569464] J Expo Sci Environ Epidemiol. 2009 Sep;19(6):544-54 [19052531] Am J Ind Med. 2001 Nov;40(5):604-11 [11675631] Occup Environ Med. 2003 Sep;60(9):634-42 [12937183] Scand J Work Environ Health. 1992 Aug;18(4):209-15 [1411362] Int Arch Occup Environ Health. 1993;65(3):163-9 [8282414] Am J Ind Med. 1996 May;29(5):501-6 [8732923] Am J Ind Med. 1997 Nov;32(5):510-6 [9327075] Ann Epidemiol. 1998 Jan;8(1):64-74 [9465996] Am J Ind Med. 1998 Sep;34(3):252-60 [9698994] Scand J Work Environ Health. 1998 Aug;24(4):255-61 [9754856] Occup Environ Med. 1999 Jan;56(1):14-21 [10341741] Occup Environ Med. 1999 Aug;56(8):548-52 [10492653] Ann Epidemiol. 2005 Apr;15(4):279-85 [15780775] Am J Epidemiol. 2005 Jun 1;161(11):1037-46 [15901624] Cancer Causes Control. 2005 May;16(4):389-97 [15953981] Scand J Work Environ Health. 2005;31 Suppl 1:9-17; discussion 5-7 [16190144] Scand J Work Environ Health. 2005;31 Suppl 1:39-45; discussion 5-7 [16190148] Ann Occup Hyg. 2007 Jan;51(1):53-65 [16984946] Cancer Causes Control. 2007 Jun;18(5):457-78 [17443416] Am J Ind Med. 2001 Nov;40(5):596-603 [11675630] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10599240902779436 ER - TY - JOUR T1 - Treatment of adolescent depression: what we have come to know. AN - 67222436; 19404989 JF - Depression and anxiety AU - Vitiello, Benedetto AD - Child and Adolescent Treatment and Preventive Interventions Research Branch, National Institute of Mental Health, Room 7147, 6001 Executive Blvd., Bethesda 20892-9633, Maryland, USA. bvitiell@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 393 EP - 395 VL - 26 IS - 5 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Index Medicus KW - Cross-Sectional Studies KW - Randomized Controlled Trials as Topic KW - Suicide, Attempted -- statistics & numerical data KW - Combined Modality Therapy KW - Humans KW - Treatment Outcome KW - Adolescent KW - Fluoxetine -- adverse effects KW - Depressive Disorder, Major -- diagnosis KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Cognitive Therapy KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depressive Disorder, Major -- psychology KW - Fluoxetine -- therapeutic use KW - Depressive Disorder, Major -- therapy KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67222436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Treatment+of+adolescent+depression%3A+what+we+have+come+to+know.&rft.au=Vitiello%2C+Benedetto&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2009-01-01&rft.volume=26&rft.issue=5&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=1520-6394&rft_id=info:doi/10.1002%2Fda.20572 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-22 N1 - Date created - 2009-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/da.20572 ER - TY - JOUR T1 - United States National Library of Medicine Drug Information Portal. AN - 67147664; 19384716 AB - The Drug Information Portal is a free Web resource from the National Library of Medicine (NLM) that provides a user-friendly gateway to current information for more than 15,000 drugs. The site guides users to related resources of NLM, the National Institutes of Health (NIH), and other government agencies. Current drug-related information regarding consumer health, clinical trials, AIDS, MeSH pharmacological actions, MEDLINE/PubMed biomedical literature, and physical properties and structure is easily retrieved by searching on a drug name. A varied selection of focused topics in medicine and drugs is also available from displayed subject headings. This column provides background information about the Drug Information Portal, as well as search basics. JF - Medical reference services quarterly AU - Hochstein, Colette AU - Goshorn, Jeanne AU - Chang, Florence AD - Division of Specialized Information Services, National Library of Medicine, Bethesda, MD 20892, USA. colette@nlm.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 154 EP - 163 VL - 28 IS - 2 KW - Hazardous Substances KW - 0 KW - Pharmaceutical Preparations KW - Health administration KW - United States KW - Clinical Trials as Topic KW - National Library of Medicine (U.S.) KW - Databases, Factual KW - Information Storage and Retrieval -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67147664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+reference+services+quarterly&rft.atitle=United+States+National+Library+of+Medicine+Drug+Information+Portal.&rft.au=Hochstein%2C+Colette%3BGoshorn%2C+Jeanne%3BChang%2C+Florence&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2009-01-01&rft.volume=28&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Medical+reference+services+quarterly&rft.issn=1540-9597&rft_id=info:doi/10.1080%2F02763860902816784 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-28 N1 - Date created - 2009-04-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Med Ref Serv Q. 2006 Spring;25(1):37-48 [16635956] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/02763860902816784 ER - TY - JOUR T1 - What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus? AN - 67142003; 18608908 AB - Gliotoxin is a member of the epipolythiodioxopiperazine class of toxins and is both the major and the most potent toxin produced by Aspergillus fumigatus. Since the discovery of the putative gliotoxin biosynthetic 12-gene cluster in the genome of A. fumigatus, five different laboratories have attempted to determine the role of this toxin in the virulence of A. fumigatus. The genes in the cluster that have been disrupted to study the pathobiological importance of gliotoxin include gliZ that encodes a transcription factor and gliP that encodes a nonribosomal peptide synthase. Two of the five laboratories have reported gliotoxin to be an important virulence determinant of A. fumigatus, while the other three laboratories have shown it to be unimportant. Comparisons of the data generated among the five laboratories revealed that the immunosuppressive regimen used for mice was the key factor that contributed to the observed disparity. Regardless of either the mouse strains used or the route of infection, immunosuppression with a combination of cyclophosphamide and corticosteroids (neutropenic mice) showed gliotoxin to be unimportant. The mice immunosuppressed with corticosteroids alone, however, revealed that gliotoxin is an important virulence determinant of A. fumigatus. These studies indicate that the neutropenic mice model is inadequate to reveal the pathobiological importance of fungal secondary metabolites in invasive pulmonary aspergillosis. JF - Medical mycology AU - Kwon-Chung, Kyung J AU - Sugui, Janyce A AD - Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. june_kwon-chung@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S97 EP - 103 VL - 47 Suppl 1 KW - Virulence Factors KW - 0 KW - Gliotoxin KW - 67-99-2 KW - Index Medicus KW - Gene Knockout Techniques KW - Animals KW - Genes, Fungal KW - Multigene Family KW - Disease Models, Animal KW - Mice KW - Immunocompromised Host KW - Aspergillus fumigatus -- pathogenicity KW - Virulence Factors -- toxicity KW - Aspergillus fumigatus -- genetics KW - Virulence Factors -- genetics KW - Gliotoxin -- biosynthesis KW - Gliotoxin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67142003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Immunology&rft.atitle=Antibody-mediated+immunity+to+the+obligate+intracellular+bacterial+pathogen+Coxiella+burnetii+is+Fc+receptor-+and+complement-independent&rft.au=Shannon%2C+Jeffrey+G%3BCockrell%2C+Diane+C%3BTakahashi%2C+Kazue%3BStahl%2C+Gregory+L%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=10&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=BMC+Immunology&rft.issn=1471-2172&rft_id=info:doi/10.1186%2F1471-2172-10-26 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-27 N1 - Date created - 2009-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bone Marrow Transplant. 2002 Jan;29(1):15-9 [11840139] Microbiol Mol Biol Rev. 2002 Sep;66(3):447-59, table of contents [12208999] Blood. 2002 Dec 15;100(13):4358-66 [12393425] Bone Marrow Transplant. 2002 Dec;30(12):925-9 [12476286] Mycopathologia. 2003;156(2):133-8 [12733634] Infect Immun. 2004 Jun;72(6):3373-82 [15155643] Antimicrob Agents Chemother. 1972 Oct;2(4):261-6 [4670497] Proc Natl Acad Sci U S A. 1984 Jun;81(12):3835-7 [6203127] Int J Immunopharmacol. 1986;8(7):789-97 [2430903] J Biol Chem. 1988 Dec 5;263(34):18493-9 [2461370] Infect Immun. 1995 Sep;63(9):3266-71 [7543879] J Exp Med. 1996 Apr 1;183(4):1829-40 [8666939] Gen Pharmacol. 1996 Dec;27(8):1311-6 [9304400] Clin Infect Dis. 1999 Feb;28(2):322-30 [10064251] Clin Microbiol Rev. 1999 Apr;12(2):310-50 [10194462] J Bacteriol. 1999 Oct;181(20):6469-77 [10515939] Blood. 2005 Mar 15;105(6):2258-65 [15546954] Microbiology. 2005 Apr;151(Pt 4):1021-32 [15817772] Nat Rev Microbiol. 2005 Jun;3(6):470-8 [15931165] FEMS Microbiol Lett. 2005 Jul 15;248(2):241-8 [15979823] Eukaryot Cell. 2005 Sep;4(9):1574-82 [16151250] J Clin Microbiol. 2005 Dec;43(12):6120-2 [16333108] Acta Pharm. 2005 Dec;55(4):365-75 [16375826] Clin Immunol. 2006 Jan;118(1):108-16 [16213796] Eukaryot Cell. 2006 Jun;5(6):972-80 [16757745] J Cell Biol. 2006 Aug 14;174(4):509-19 [16893972] Mol Microbiol. 2006 Oct;62(1):292-302 [16956378] Infect Immun. 2006 Dec;74(12):6761-8 [17030582] Biochemistry. 2006 Dec 19;45(50):15029-38 [17154540] Biol Lett. 2007 Oct 22;3(5):523-5 [17686752] Eukaryot Cell. 2007 Sep;6(9):1562-9 [17601876] Eukaryot Cell. 2007 Sep;6(9):1552-61 [17630330] J Leukoc Biol. 2007 Oct;82(4):839-48 [17626149] BMC Evol Biol. 2007;7:174 [17897469] J Infect Dis. 2008 Feb 1;197(3):479-86 [18199036] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/13693780802056012 ER - TY - JOUR T1 - Colobronchial fistula: an unusual complication after peritonectomy and hyperthermic intra-peritoneal chemotherapy (HIPEC). AN - 67141389; 19368141 AB - Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an innovative approach to peritoneal carcinomatosis. Due to the complexity of the combined procedure, high rates of potentially life-threatening complications have been reported. This is the first report of colobronchial fistula following CRS and HIPEC. A 70-year-old woman underwent CRS and HIPEC for papillary well-differentiated peritoneal mesothelioma. During the postoperative course, recurrent pneumonia occurred and bacteria of intestinal origin were isolated from expectorated sputum. Water-soluble contrast studies revealed direct communication between the left colon flexure and the bronchial tree. After appropriate medical and supportive therapies, the patient underwent resection of the splenic flexure and immediate anastomosis with complete recovery. Colobronchial fistula is a rare and potentially lethal complication of CRS and HIPEC. A suggestive clinical picture and contrast studies allow conclusive diagnosis to be made. Surgery is a safe and effective therapeutic option. JF - In vivo (Athens, Greece) AU - Laterza, Barbara AU - Baratti, Dario AU - Cozzi, Guido AU - Kusamura, Shigeki AU - Oliva, Grazia Daniela AU - Gavazzi, Cecilia AU - Fumagalli, Luca AU - Sironi, Alessandro AU - Sabia, Domenico AU - Deraco, Marcello AD - Department of Surgery, National Cancer Institute, Milan, Italy. PY - 2009 SP - 151 EP - 153 VL - 23 IS - 1 SN - 0258-851X, 0258-851X KW - Index Medicus KW - Colon KW - Combined Modality Therapy KW - Peritoneum -- surgery KW - Humans KW - Treatment Outcome KW - Aged KW - Radiography KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Female KW - Mesothelioma -- therapy KW - Intestinal Fistula -- diagnostic imaging KW - Peritoneal Neoplasms -- pathology KW - Hyperthermia, Induced -- adverse effects KW - Mesothelioma -- pathology KW - Bronchial Fistula -- surgery KW - Postoperative Complications -- pathology KW - Postoperative Complications -- etiology KW - Intestinal Fistula -- surgery KW - Intestinal Fistula -- etiology KW - Bronchial Fistula -- etiology KW - Peritoneal Neoplasms -- therapy KW - Bronchial Fistula -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67141389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Colobronchial+fistula%3A+an+unusual+complication+after+peritonectomy+and+hyperthermic+intra-peritoneal+chemotherapy+%28HIPEC%29.&rft.au=Laterza%2C+Barbara%3BBaratti%2C+Dario%3BCozzi%2C+Guido%3BKusamura%2C+Shigeki%3BOliva%2C+Grazia+Daniela%3BGavazzi%2C+Cecilia%3BFumagalli%2C+Luca%3BSironi%2C+Alessandro%3BSabia%2C+Domenico%3BDeraco%2C+Marcello&rft.aulast=Laterza&rft.aufirst=Barbara&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies. AN - 67118532; 19344187 AB - Immunotoxins are molecules that contain a protein toxin and a ligand that is either an antibody or a growth factor. The ligand binds to a target cell antigen, and the target cell internalizes the immunotoxin, allowing the toxin to migrate to the cytoplasm where it can kill the cell. In the case of recombinant immunotoxins, the ligand and toxin are encoded in DNA that is then expressed in bacteria, and the purified immunotoxin contains the ligand and toxin fused together. Among the most active recombinant immunotoxins clinically tested are those that are targeted to hematologic malignancies. One agent, containing human interleukin-2 and truncated diphtheria toxin (denileukin diftitox), has been approved for use in cutaneous T-cell lymphoma, and has shown activity in other hematologic malignancies, including leukemias and lymphomas. Diphtheria toxin has also been targeted by other ligands, including granulocyte-macrophage colony-stimulating factor and interleukin-3, to target myelogenous leukemia cells. Single-chain antibodies containing variable heavy and light antibody domains have been fused to truncated Pseudomonas exotoxin to target lymphomas and lymphocytic leukemias. Recombinant immunotoxins anti-Tac(Fv)-PE38 (LMB-2), targeting CD25, and RFB4(dsFv)-PE38 (BL22, CAT-3888), targeting CD22, have each been tested in patients. Major responses have been observed after failure of standard chemotherapy. The most successful application of recombinant immunotoxins today is in hairy cell leukemia, where BL22 has induced complete remissions in most patients who were previously treated with optimal chemotherapy. JF - BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy AU - Kreitman, Robert J AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. kreitmar@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1 EP - 13 VL - 23 IS - 1 KW - Antibodies KW - 0 KW - Antibodies, Monoclonal KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Bacterial Toxins KW - Diphtheria Toxin KW - Enterotoxins KW - Exotoxins KW - Immunotoxins KW - Interleukin-2 KW - RFB4(dsFv)-PE38 recombinant immunotoxin KW - Recombinant Fusion Proteins KW - denileukin diftitox KW - 25E79B5CTM KW - Index Medicus KW - Animals KW - Antibodies -- therapeutic use KW - Interleukin-2 -- therapeutic use KW - Humans KW - Treatment Outcome KW - Enterotoxins -- therapeutic use KW - Diphtheria Toxin -- therapeutic use KW - Exotoxins -- therapeutic use KW - Recombinant Fusion Proteins -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use KW - Hematologic Neoplasms -- therapy KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- adverse effects KW - Immunotoxins -- adverse effects KW - Bacterial Toxins -- therapeutic use KW - Immunotoxins -- therapeutic use KW - Hematologic Neoplasms -- immunology KW - Immunotoxins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67118532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.atitle=Recombinant+immunotoxins+containing+truncated+bacterial+toxins+for+the+treatment+of+hematologic+malignancies.&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.issn=1179-190X&rft_id=info:doi/10.2165%2F00063030-200923010-00001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-04 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Jpn J Cancer Res. 1990 Sep;81(9):902-8 [2121691] J Biol Chem. 1990 Nov 25;265(33):20673-7 [2243114] Proc Natl Acad 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Lymphoma. 2002 Apr;43(4):885-8 [12153180] Leukemia. 2003 Jan;17(1):155-9 [12529673] Traffic. 2006 Apr;7(4):379-93 [16536737] Ann Intern Med. 1997 Jun 1;126(11):882-5 [9163289] Leuk Lymphoma. 1997 Apr;25(3-4):381-5 [9168448] Toxicol Lett. 1997 Apr 28;91(2):121-7 [9175848] Biochem Soc Trans. 1997 May;25(2):709-14 [9191188] Blood. 1997 Jul 1;90(1):252-9 [9207460] Eur J Immunol. 1997 Jun;27(6):1459-68 [9209499] Blood. 1997 Sep 1;90(5):2020-6 [9292538] J Biol Chem. 1997 Sep 26;272(39):24165-9 [9305866] Biochemistry. 1997 Nov 25;36(47):14577-82 [9398176] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2165/00063030-200923010-00001 ER - TY - JOUR T1 - Collection and preparation of rodent tissue samples for histopathological and molecular studies in carcinogenesis. AN - 67112480; 19347291 AB - Histology, as a mean of tissue visualization on a cellular level, is a fundamental tool in the study of cancer. The need for simultaneous delivery of quality histological material for pathological evaluation and subsequent genomic and proteomic studies, however, requires modification of traditional practices to include rapid isolation and stabilization of target tissue to preserve molecular integrity. Informative molecular analysis depends on the integrity of target molecules (RNA, DNA, and proteins) in the tissue during and after its collection. A reliable systematic approach to routine and genomic/proteomic sample collection and preparation presented is supported by detailed protocols. JF - Methods in molecular biology (Clifton, N.J.) AU - Golubeva, Yelena AU - Rogers, Keith AD - Histotechnology Laboratory, NCI-Frederick, SAIC-Frederick, Frederick, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 3 EP - 60 VL - 511 SN - 1064-3745, 1064-3745 KW - RNA, Neoplasm KW - 0 KW - Index Medicus KW - Biological Assay -- methods KW - Animals KW - Microdissection -- methods KW - Genomics -- methods KW - Microdissection -- instrumentation KW - Humans KW - RNA Stability KW - Biological Assay -- instrumentation KW - Mice KW - Lasers KW - RNA, Neoplasm -- analysis KW - Female KW - Histocytochemistry -- methods KW - Neoplasms -- pathology KW - Tissue Fixation -- methods KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67112480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Collection+and+preparation+of+rodent+tissue+samples+for+histopathological+and+molecular+studies+in+carcinogenesis.&rft.au=Golubeva%2C+Yelena%3BRogers%2C+Keith&rft.aulast=Golubeva&rft.aufirst=Yelena&rft.date=2009-01-01&rft.volume=511&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-447-6_1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-18 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-447-6_1 ER - TY - JOUR T1 - Automation in an addiction treatment research clinic: computerised contingency management, ecological momentary assessment and a protocol workflow system. AN - 67073985; 19320669 AB - A challenge in treatment research is the necessity of adhering to protocol and regulatory strictures while maintaining flexibility to meet patients' treatment needs and to accommodate variations among protocols. Another challenge is the acquisition of large amounts of data in an occasionally hectic environment, along with the provision of seamless methods for exporting, mining and querying the data. We have automated several major functions of our outpatient treatment research clinic for studies in drug abuse and dependence. Here we describe three such specialised applications: the Automated Contingency Management (ACM) system for the delivery of behavioural interventions, the transactional electronic diary (TED) system for the management of behavioural assessments and the Protocol Workflow System (PWS) for computerised workflow automation and guidance of each participant's daily clinic activities. These modules are integrated into our larger information system to enable data sharing in real time among authorised staff. ACM and the TED have each permitted us to conduct research that was not previously possible. In addition, the time to data analysis at the end of each study is substantially shorter. With the implementation of the PWS, we have been able to manage a research clinic with an 80 patient capacity, having an annual average of 18,000 patient visits and 7300 urine collections with a research staff of five. Finally, automated data management has considerably enhanced our ability to monitor and summarise participant safety data for research oversight. When developed in consultation with end users, automation in treatment research clinics can enable more efficient operations, better communication among staff and expansions in research methods. JF - Drug and alcohol review AU - Vahabzadeh, Massoud AU - Lin, Jia-Ling AU - Mezghanni, Mustapha AU - Epstein, David H AU - Preston, Kenzie L AD - Biomedical Informatics Section, Administrative Management Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, Maryland 21224, USA. massoudv@nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 3 EP - 11 VL - 28 IS - 1 KW - Index Medicus KW - Ambulatory Care -- organization & administration KW - Efficiency, Organizational KW - Humans KW - Decision Support Systems, Clinical KW - Communication KW - Automation -- methods KW - Behavior Therapy -- methods KW - Time Factors KW - Substance Abuse Detection -- methods KW - Research Design -- legislation & jurisprudence KW - Information Systems KW - Substance Abuse Treatment Centers -- organization & administration KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67073985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+review&rft.atitle=Automation+in+an+addiction+treatment+research+clinic%3A+computerised+contingency+management%2C+ecological+momentary+assessment+and+a+protocol+workflow+system.&rft.au=Vahabzadeh%2C+Massoud%3BLin%2C+Jia-Ling%3BMezghanni%2C+Mustapha%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Vahabzadeh&rft.aufirst=Massoud&rft.date=2009-01-01&rft.volume=28&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+review&rft.issn=1465-3362&rft_id=info:doi/10.1111%2Fj.1465-3362.2008.00007.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Consult Clin Psychol. 2007 Oct;75(5):765-74 [17907858] J Am Med Inform Assoc. 2007 Jul-Aug;14(4):415-23 [17460127] J Am Med Inform Assoc. 2007 May-Jun;14(3):387-8; discussion 389 [17329719] J Investig Med. 2006 May;54(4):171-3 [17152855] J Investig Med. 2006 Sep;54(6):327-33 [17134616] J Am Med Inform Assoc. 2006 Sep-Oct;13(5):547-56 [16799128] AMIA Annu Symp Proc. 2005;:455-9 [16779081] Arch Gen Psychiatry. 2006 Feb;63(2):201-8 [16461864] BMJ. 2005 Dec 3;331(7528):1313-6 [16269467] J Consult Clin Psychol. 2005 Apr;73(2):354-9 [15796645] J Nerv Ment Dis. 1987 Sep;175(9):526-36 [3655778] J Biomed Inform. 2003 Jun;36(3):218-27 [14615230] JAMA. 2003 Mar 12;289(10):1278-87 [12633190] J Am Med Inform Assoc. 2000 Mar-Apr;7(2):135-45 [10730596] Drug Alcohol Depend. 2000 Feb 1;58(1-2):9-25 [10669051] Health Policy. 2007 Dec;84(2-3):181-90 [17624470] J Appl Behav Anal. 2008 Winter;41(4):539-49 [19192858] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1465-3362.2008.00007.x ER - TY - JOUR T1 - PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells. AN - 67047488; 19305641 AB - Cytoplasmic expression of claudin-1 in metastatic melanoma cells correlates to increased migration, and increased secretion of MMP-2 in a PKC dependent manner, whereas claudin-1 nuclear expression is found in benign nevi. Melanoma cells were transfected with a vector expressing CLDN-1 fused to a nuclear localization signal (NLS). Despite significant nuclear localization of claudin-1, there was still transport of claudin-1 to the cytoplasm. Phorbol ester treatment of cells transfected with NLS-claudin-1 resulted in an exclusion of claudin-1 from the nucleus, despite the NLS. To ascertain whether PKC or PKA were involved in this translocation, we mutated the putative phosphorylation sites within the protein. We found that mutating the PKC phosphorylation sites to mimic a non-phosphorylated state did not cause a shift of claudin-1 to the nucleus of the cells, but mutating the PKA sites did. Mutations of either site to mimic constitutive phosphorylation resulted in cytoplasmic claudin-1 expression. Stable claudin-1 transfectants containing non-phosphorylatable PKA sites exhibited decreased motility. These data imply that subcellular localization of claudin-1 can be controlled by phosphorylation, dicating effects on metastatic capacity. JF - International journal of medical sciences AU - French, Amanda D AU - Fiori, Jennifer L AU - Camilli, Tura C AU - Leotlela, Poloko D AU - O'Connell, Michael P AU - Frank, Brittany P AU - Subaran, Sarah AU - Indig, Fred E AU - Taub, Dennis D AU - Weeraratna, Ashani T AD - Laboratory of Immunology, National Institute on Aging, Baltimore, MD 21124, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 93 EP - 101 VL - 6 IS - 2 KW - CLDN1 protein, human KW - 0 KW - Claudin-1 KW - Membrane Proteins KW - Nuclear Localization Signals KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - PKA KW - metastasis KW - Claudin KW - melanoma KW - PKC KW - Neoplasm Invasiveness KW - Computer Simulation KW - Cell Nucleus -- metabolism KW - Enzyme Activation KW - Humans KW - Biological Transport -- genetics KW - Cell Line, Tumor KW - Cell Nucleus -- drug effects KW - Nuclear Localization Signals -- metabolism KW - Matrix Metalloproteinase 2 -- metabolism KW - Mutagenesis, Site-Directed KW - Phosphorylation KW - Cytoplasm -- genetics KW - Transfection KW - Cytoplasm -- metabolism KW - Genetic Vectors KW - Neoplasm Metastasis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Subcellular Fractions -- metabolism KW - Nuclear Localization Signals -- genetics KW - Immunohistochemistry KW - Cell Nucleus -- genetics KW - Protein Kinase C -- metabolism KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Melanoma -- pathology KW - Membrane Proteins -- metabolism KW - Melanoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67047488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+medical+sciences&rft.atitle=PKC+and+PKA+phosphorylation+affect+the+subcellular+localization+of+claudin-1+in+melanoma+cells.&rft.au=French%2C+Amanda+D%3BFiori%2C+Jennifer+L%3BCamilli%2C+Tura+C%3BLeotlela%2C+Poloko+D%3BO%27Connell%2C+Michael+P%3BFrank%2C+Brittany+P%3BSubaran%2C+Sarah%3BIndig%2C+Fred+E%3BTaub%2C+Dennis+D%3BWeeraratna%2C+Ashani+T&rft.aulast=French&rft.aufirst=Amanda&rft.date=2009-01-01&rft.volume=6&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=International+journal+of+medical+sciences&rft.issn=1449-1907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2009-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroreport. 2000 May 15;11(7):1427-31 [10841351] Methods Mol Biol. 2008;468:243-53 [19099260] Traffic. 2001 Feb;2(2):93-8 [11247307] J Cell Biol. 2002 Mar 18;156(6):1099-111 [11889141] Oncol Res. 2001;12(11-12):469-76 [11939410] Cancer Cell. 2002 Apr;1(3):279-88 [12086864] J Biol Chem. 2003 Jan 24;278(4):2692-700 [12403786] Am J Physiol Cell Physiol. 2003 Aug;285(2):C300-9 [12660149] J Biol Chem. 2004 Aug 20;279(34):35702-8 [15187091] Am J Pathol. 2005 May;166(5):1541-54 [15855653] J Biol Chem. 2005 Jul 15;280(28):26233-40 [15905176] J Clin Invest. 2005 Jul;115(7):1765-76 [15965503] Cancer Res. 2005 Nov 1;65(21):9603-6 [16266975] Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H381-9 [16155104] Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):287-91 [16831296] Oncogene. 2007 May 31;26(26):3846-56 [17160014] J Biol Chem. 2007 Jun 8;282(23):17259-71 [17426020] Mol Pharmacol. 2008 Aug;74(2):432-42 [18477669] PLoS One. 2008;3(7):e2715 [18648642] Cancer Res. 2008 Dec 15;68(24):10205-14 [19074888] Cancer Res. 2000 Nov 15;60(22):6281-7 [11103784] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - EEG and cerebral blood flow velocity abnormalities in chronic cocaine users. AN - 67016958; 19278131 AB - EEG and cerebral blood flow abnormalities have been documented in chronic cocaine abusers. To identify possible relationships between EEG and blood flow changes and their relationship to the intensity of cocaine use, we recorded the resting eyes-closed EEG and anterior (ACA) and middle (MCA) cerebral artery blood flow velocity during systole (V(S)) and diastole (V(D)) by transcranial Doppler (TCD) sonography of 99 (76 male, 23 female; mean [SD] age 34.3 [5.2] years, 8.6 [5.5] years of cocaine use, 17.8 [7.7] days of cocaine use in month prior to screening) cocaine users within 5 days of admission to a closed research unit. Forty-two non-drug-using, age-matched control subjects (22 male, 20 female) were tested as outpatients. A 3-minute period of resting EEG was recorded from 16 standard scalp electrodes. Artifact-free EEG was converted to six frequency bands (delta, theta, alpha1, alpha2, beta1 and beta2) using a Fast Fourier Transform. Pulsatility index (PI) was calculated as a measure of small vessel resistance. Cocaine users had decreased VD and increased PI in the MCA, with no difference in V(S), and reduced EEG theta, beta1 and beta2 absolute power in posterior brain regions. Recent cocaine use was positively associated with MCA PI (r = 0.27, p < 0.001) and negatively associated with low frequency EEG power (delta power: r = -0.25, p < 0.002; theta power: r = -0.29, p < 0.001). EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence. JF - Clinical EEG and neuroscience AU - Copersino, Marc L AU - Herning, Ronald I AU - Better, Warren AU - Cadet, Jean-Lud AU - Gorelick, David A AD - Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 39 EP - 42 VL - 40 IS - 1 SN - 1550-0594, 1550-0594 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Analysis of Variance KW - Blood Flow Velocity KW - Humans KW - Adult KW - Ultrasonography, Doppler, Transcranial KW - Cocaine -- toxicity KW - Fourier Analysis KW - Male KW - Female KW - Anterior Cerebral Artery -- drug effects KW - Brain -- blood supply KW - Brain -- drug effects KW - Electroencephalography KW - Anterior Cerebral Artery -- diagnostic imaging KW - Cerebrovascular Circulation KW - Middle Cerebral Artery -- diagnostic imaging KW - Cocaine-Related Disorders -- diagnostic imaging KW - Brain -- physiopathology KW - Middle Cerebral Artery -- physiopathology KW - Middle Cerebral Artery -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Anterior Cerebral Artery -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67016958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+and+neuroscience&rft.atitle=EEG+and+cerebral+blood+flow+velocity+abnormalities+in+chronic+cocaine+users.&rft.au=Copersino%2C+Marc+L%3BHerning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean-Lud%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2009-01-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+and+neuroscience&rft.issn=15500594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-03 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addict Behav. 1994 Nov-Dec;19(6):599-607 [7701971] J Nucl Med. 1995 Jul;36(7):1211-5 [7790946] J Neurosurg. 1996 Jan;84(1):79-84 [8613840] Psychiatry Res. 1995 Oct 16;58(3):247-57 [8570780] Epilepsia. 1996 Sep;37(9):875-8 [8814101] Biol Psychiatry. 1996 Nov 15;40(10):986-93 [8915557] Neurology. 1997 Feb;48(2):341-5 [9040718] Biol Psychiatry. 1997 Jun 1;41(11):1087-94 [9146819] Drug Alcohol Depend. 1997 Jun 6;46(1-2):87-93 [9246556] Neuropsychopharmacology. 1998 Jul;19(1):1-9 [9608571] Biol Psychiatry. 1999 May 1;45(9):1203-11 [10331113] J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):209-21 [10333992] Neuropsychopharmacology. 1999 Jul;21(1):110-8 [10379525] J Clin Neurophysiol. 2004 Sep-Oct;21(5):341-52 [15592008] Arch Gen Psychiatry. 2007 Apr;64(4):495-502 [17404126] Postgrad Med J. 2007 Jun;83(980):389-94 [17551070] Clin Neurophysiol. 2000 Apr;111(4):604-12 [10727911] Stroke. 2000 May;31(5):1111-5 [10797173] Neuropsychobiology. 2000;42(2):93-8 [10940764] Clin Neurophysiol. 2000 Nov;111(11):1961-7 [11068230] Neuropsychopharmacology. 2001 Sep;25(3):332-40 [11522462] Stroke. 2001 Oct;32(10):2338-43 [11588323] Epilepsia. 2002;43 Suppl 2:28-31 [11903480] Biol Psychiatry. 2002 Oct 15;52(8):831-42 [12372655] J Psychoactive Drugs. 2002 Oct-Dec;34(4):415-9 [12562110] Stroke. 2003 Jun;34(6):1375-81 [12764233] Radiology. 1990 Sep;176(3):821-4 [2389042] Am J Drug Alcohol Abuse. 1990;16(3-4):307-17 [2126913] Headache. 1991 Jan;31(1):17-9 [2016163] J Nucl Med. 1991 Jun;32(6):1206-10 [2045934] Psychiatry Res. 1990 Dec;35(2):95-105 [2100807] J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):803-6 [1955899] J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):419-27 [8286941] J Nucl Med. 1994 Dec;35(12):1902-9 [7989967] Neuropsychobiology. 1994;30(4):189-96 [7862268] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Helicobacter Pylori associated global gastric cancer burden. AN - 67013314; 19273142 AB - Helicobacter pylori infection is ubiquitous, infecting close to one-half of the world's population, but its prevalence is declining in developed countries. Chronic H. pylori infection is etiologically linked to gastric adenocarcinoma, especially non-cardia type (63% of all stomach cancer or ~5.5% of the global cancer burden: ~25% of cancers associated with infectious etiology), and to gastric mucosal associated lymphoid tissue (MALT) lymphoma, which accounts for up to 8% of all non-Hodgkin lymphoma. Epidemiological, clinical, and animal studies have established a central role for H. pylori in gastric carcinogenesis and provided insights into the mechanisms and biologic relationships between bacterial infection, host genetics, nutrition, and environmental factors. These discoveries invite strategies to prevent infection to be the logical primary goals in a multi-pronged effort to curtail suffering and death from H. pylori infection-associated cancers. JF - Frontiers in bioscience (Landmark edition) AU - Mbulaiteye, Sam M AU - Hisada, Michie AU - El-Omar, Emad M AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. mbulaits@mail.nih.gov Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 1490 EP - 1504 VL - 14 KW - Index Medicus KW - Virulence KW - Global Health KW - Risk Factors KW - Humans KW - Incidence KW - Stomach Neoplasms -- microbiology KW - Lymphoma, B-Cell, Marginal Zone -- prevention & control KW - Lymphoma, B-Cell, Marginal Zone -- microbiology KW - Lymphoma, B-Cell, Marginal Zone -- epidemiology KW - Helicobacter pylori -- pathogenicity KW - Stomach Neoplasms -- prevention & control KW - Stomach Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67013314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%28Landmark+edition%29&rft.atitle=Helicobacter+Pylori+associated+global+gastric+cancer+burden.&rft.au=Mbulaiteye%2C+Sam+M%3BHisada%2C+Michie%3BEl-Omar%2C+Emad+M&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2009-01-01&rft.volume=14&rft.issue=&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%28Landmark+edition%29&rft.issn=1093-4715&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Scand J Gastroenterol. 1997 Jan;32(1):28-33 [9018763] Semin Gastrointest Dis. 1997 Jul;8(3):142-55 [9232727] Gastroenterology. 1998 Jun;114(6):1169-79 [9609753] J Infect Dis. 1998 Sep;178(3):717-21 [9728540] Pediatr Res. 1999 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Infect Immun. 2003 Jun;71(6):3496-502 [12761134] IARC Sci Publ. 2002;(155):1-781 [12812229] Cancer Sci. 2003 Mar;94(3):235-9 [12824915] Gastroenterology. 2003 Aug;125(2):364-71 [12891537] Gut. 2003 Dec;52(12):1684-9 [14633943] JAMA. 2004 Jan 14;291(2):187-94 [14722144] Gastroenterology. 2003 Dec;125(6):1636-44 [14724815] Curr Top Med Chem. 2004;4(5):531-8 [14965304] Helicobacter. 2004 Jun;9(3):262-70 [15165263] J Gastroenterol. 2004;39(5):429-33 [15175940] Gastroenterology. 2004 Jul;127(1):73-9 [15236174] Aliment Pharmacol Ther. 2004 Jul;20 Suppl 1:1-6 [15298598] Nat Rev Cancer. 2004 Sep;4(9):688-94 [15343275] Leukemia. 2004 Oct;18(10):1722-6 [15356642] J Infect Dis. 2004 Nov 1;190(9):1605-9 [15478065] Br Med J. 1965 Sep 25;2(5464):719-22 [4283943] East Afr Med J. 1966 Jul;43(7):274-83 [5911333] Lancet. 1984 Jun 16;1(8390):1311-5 [6145023] Med J Aust. 1985 Apr 15;142(8):439-44 [3982346] Epidemiol Rev. 1986;8:1-27 [3533579] Afr J Med Med Sci. 1988 Jun;17(2):89-95 [2843023] Cancer Res. 1990 Aug 1;50(15):4737-40 [2369748] Am J Gastroenterol. 1992 Jan;87(1):28-30 [1728121] Lancet. 1993 Sep 4;342(8871):575-7 [8102719] Gut. 1993 Dec;34(12):1672-6 [8282253] Gastroenterology. 1996 Aug;111(2):426-32 [8690208] Scand J Gastroenterol Suppl. 1996;220:23-6 [8898432] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine content and delivery across tobacco products. AN - 66873681; 19184646 AB - Nicotine is the principal alkaloid in both commercial and homemade products (e.g., cigarettes, smokeless tobacco, bidis, waterpipes) followed by nornicotine, anabasine, anatabine, and many other basic substances that contain a cyclic nitrogenous nucleus. Tobacco types, leaf position on the plant, agricultural practices, fertilizer treatment, and degree of ripening are among some prominent factors that determine the levels of alkaloids in tobacco leaf. From a random examination of 152 cultivated varieties of Nicotiana tabacum, a range of alkaloid variation between 0.17 and 4.93% was determined. In fact, every step in tobacco production that affects plant metabolism will influence the level of alkaloid content to a certain degree. Depending on blending recipe, type and amount of additives, and product design, all types of tobacco products contain a very wide range of nicotine concentration. However, the ultimate emission of nicotine to the user, exposure, and psychophar-macological effects depend not only on the content and emission, but also on the relationship between the product and the user. JF - Handbook of experimental pharmacology AU - Djordjevic, Mirjana V AU - Doran, Kelly A AD - Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd, EPN 4048, MSC 7337, Bethesda, MD 20892-7337, USA. djordjev@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 61 EP - 82 IS - 192 SN - 0171-2004, 0171-2004 KW - Alkaloids KW - 0 KW - Nicotinic Agonists KW - Tobacco Smoke Pollution KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Alkaloids -- chemistry KW - Humans KW - Smoking -- metabolism KW - Tobacco Smoke Pollution -- analysis KW - Tobacco, Smokeless -- chemistry KW - Plant Leaves -- chemistry KW - Tobacco -- chemistry KW - Nicotinic Agonists -- chemistry KW - Nicotine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66873681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Nicotine+content+and+delivery+across+tobacco+products.&rft.au=Djordjevic%2C+Mirjana+V%3BDoran%2C+Kelly+A&rft.aulast=Djordjevic&rft.aufirst=Mirjana&rft.date=2009-01-01&rft.volume=&rft.issue=192&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-69248-5_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-3-540-69248-5_3 ER - TY - JOUR T1 - Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. AN - 66850292; 19015200 AB - Androgens and estrogens may play a role in gastric cancer etiology. To investigate the association of gastric cancer with single-nucleotide polymorphisms (SNPs) in six genes (COMT, CYP1B1, CYP17A1, CYP19A1, HSD17B1 and SHBG) involved in estrogen and androgen synthesis and metabolism, 58 haplotype-tagging SNPs were genotyped in 295 gastric cancer cases and 415 controls from a population-based study in Poland. We assessed differences in haplotype frequency between cases and controls using a global score test and calculated multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for individual haplotypes using logistic regression. We found associations in one linkage disequilibrium (LD) block containing the 3' untranslated region of COMT (rs9332377, rs165728, rs165849 and rs1110478), global score test (df = 4, P = 0.033). Relative to the most frequent GATA haplotype, the GATG haplotype was associated with statistically significant increased gastric cancer risk (OR = 1.50, 95% CI: 1.06-2.12; false discovery rate (FDR) value = 0.459) and the AACA haplotype with borderline increased risk (OR = 1.36, 95% CI = 1.00-1.85; FDR = 0.50). We also found associations for the LD block containing part of the SHBG coding region (rs6258, rs6259, rs2955617, rs1641544 and rs1641537). The CACCC haplotype was associated with statistically significant lower gastric cancer risk relative to the referent CGACC haplotype (OR = 0.55, 95% CI = 0.34-0.90; FDR = 0.459), but the overall score test was statistically non-significant. No other statistically significant associations were observed. In summary, we found possible associations between gastric cancer and polymorphisms in COMT, involved in estrogen inactivation, and SHBG, a modulator of hormone bioavailability. These findings should be interpreted cautiously until replicated in other studies. JF - Carcinogenesis AU - Freedman, Neal D AU - Ahn, Jiyoung AU - Hou, Lifang AU - Lissowska, Jolanta AU - Zatonski, Witold AU - Yeager, Meredith AU - Chanock, Stephen J AU - Chow, Wong Ho AU - Abnet, Christian C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20852, USA. freedmanne@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 71 EP - 77 VL - 30 IS - 1 KW - Androgens KW - 0 KW - Estrogens KW - Index Medicus KW - Humans KW - Male KW - Female KW - Risk Assessment KW - Polymorphism, Single Nucleotide KW - Stomach Neoplasms -- metabolism KW - Estrogens -- metabolism KW - Stomach Neoplasms -- genetics KW - Androgens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66850292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+estrogen-+and+androgen-metabolizing+genes+and+the+risk+of+gastric+cancer.&rft.au=Freedman%2C+Neal+D%3BAhn%2C+Jiyoung%3BHou%2C+Lifang%3BLissowska%2C+Jolanta%3BZatonski%2C+Witold%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BChow%2C+Wong+Ho%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2009-01-01&rft.volume=69&rft.issue=1&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-2490 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1999 Jun 11;81(6):871-6 [10362132] Nat Rev Cancer. 2005 Dec;5(12):977-85 [16341085] Breast Cancer Res Treat. 1999 Mar;54(2):101-7 [10424400] Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2203-7 [15598781] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):329-35 [15734954] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Am J Hum Genet. 2005 May;76(5):887-93 [15789306] J Clin Endocrinol Metab. 2005 Apr;90(4):2198-204 [15634719] Eur J Cell Biol. 2005 Mar;84(2-3):205-14 [15819401] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1096-101 [15894658] Cancer Lett. 2005 Sep 28;227(2):115-24 [16112414] Cancer Causes Control. 2000 Oct;11(9):869-74 [11075877] Ann Oncol. 2000 Dec;11(12):1537-43 [11205460] Pharmacogenetics. 2001 Nov;11(8):655-61 [11692073] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Cancer Lett. 2002 Feb 25;176(2):129-35 [11804739] Int J Cancer. 2002 Feb 20;97(6):833-8 [11857364] Gastric Cancer. 2002;5(4):213-9 [12491079] Cancer Causes Control. 2003 Feb;14(1):53-9 [12708725] Pigment Cell Res. 2003 Jun;16(3):190-7 [12753385] Am J Hum Genet. 2003 Jul;73(1):152-61 [12802784] Hum Hered. 2003;55(1):56-65 [12890927] J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):477-86 [14623547] J Natl Cancer Inst. 2004 Jun 16;96(12):936-45 [15199113] Infect Immun. 2004 Sep;72(9):5181-92 [15322013] J Cancer Res Clin Oncol. 2004 May;130(5):253-8 [14963700] Am J Epidemiol. 2004 Oct 15;160(8):729-40 [15466495] Cancer Res. 1982 Dec;42(12):5181-2 [7139622] J Clin Endocrinol Metab. 1992 Oct;75(4):1066-70 [1400872] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Br J Cancer. 2006 Jan 16;94(1):136-41 [16404367] Cancer Res. 2006 Feb 15;66(4):2468-75 [16489054] PLoS Genet. 2005 Nov;1(5):e68 [16311626] Breast Cancer Res Treat. 2006 Sep;99(2):235-40 [16596327] Cancer Res. 2006 Oct 1;66(19):9781-5 [17018638] Ann Epidemiol. 2006 Dec;16(12):908-16 [16843679] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):165-8 [17220347] Cancer Res. 2007 Mar 1;67(5):1893-7 [17325027] Cancer. 2007 Apr 1;109(7):1296-302 [17315164] BMC Cancer. 2007;7:60 [17411440] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):969-78 [17507624] Gut. 2007 Dec;56(12):1671-7 [17627962] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2237-46 [18006912] Carcinogenesis. 2007 Dec;28(12):2597-604 [17724378] Am J Gastroenterol. 2008 Jun;103(6):1476-87 [18510611] Protein Sci. 1992 Jul;1(7):902-9 [1304375] Int J Cancer. 1994 Mar 15;56(6):812-5 [8119771] Int J Cancer. 1994 Dec 15;59(6):761-4 [7989115] J Natl Cancer Inst. 1995 May 3;87(9):645-51 [7752269] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] J Clin Endocrinol Metab. 1998 Jan;83(1):235-40 [9435448] Carcinogenesis. 1998 Jan;19(1):1-27 [9472688] Am J Epidemiol. 1999 Apr 15;149(8):706-11 [10206619] Cell. 2005 Sep 9;122(5):751-62 [16143106] J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):481-5 [10419028] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn258 ER - TY - JOUR T1 - Base excision repair of oxidative DNA damage and association with cancer and aging. AN - 66848833; 18978338 AB - Aging has been associated with damage accumulation in the genome and with increased cancer incidence. Reactive oxygen species (ROS) are produced from endogenous sources, most notably the oxidative metabolism in the mitochondria, and from exogenous sources, such as ionizing radiation. ROS attack DNA readily, generating a variety of DNA lesions, such as oxidized bases and strand breaks. If not properly removed, DNA damage can be potentially devastating to normal cell physiology, leading to mutagenesis and/or cell death, especially in the case of cytotoxic lesions that block the progression of DNA/RNA polymerases. Damage-induced mutagenesis has been linked to various malignancies. The major mechanism that cells use to repair oxidative damage lesions, such as 8-hydroxyguanine, formamidopyrimidines, and 5-hydroxyuracil, is base excision repair (BER). The BER pathway in the nucleus is well elucidated. More recently, BER was shown to also exist in the mitochondria. Here, we review the association of BER of oxidative DNA damage with aging, cancer and other diseases. JF - Carcinogenesis AU - Maynard, Scott AU - Schurman, Shepherd H AU - Harboe, Charlotte AU - de Souza-Pinto, Nadja C AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 2 EP - 10 VL - 30 IS - 1 KW - Reactive Oxygen Species KW - 0 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Humans KW - Subcellular Fractions -- metabolism KW - Base Pairing KW - DNA Repair KW - DNA Damage KW - Oxidative Stress KW - Neoplasms -- genetics KW - Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66848833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Base+excision+repair+of+oxidative+DNA+damage+and+association+with+cancer+and+aging.&rft.au=Maynard%2C+Scott%3BSchurman%2C+Shepherd+H%3BHarboe%2C+Charlotte%3Bde+Souza-Pinto%2C+Nadja+C%3BBohr%2C+Vilhelm+A&rft.aulast=Maynard&rft.aufirst=Scott&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn250 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9 [9012815] Nucleic Acids Res. 1997 Feb 15;25(4):750-5 [9016624] Science. 2005 Jul 15;309(5733):481-4 [16020738] Cancer Epidemiol Biomarkers 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1990;77(5):501-2 [2400824] Cancer Res. 1991 Feb 1;51(3):794-8 [1846317] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn250 ER - TY - JOUR T1 - The role of toxicoproteomics in assessing organ specific toxicity. AN - 66838550; 19157068 AB - Aims of this chapter on the role of toxicoproteomics in assessing organ-specific toxicity are to define the field of toxicoproteomics, describe its development among global technologies, and show potential uses in experimental toxicological research, preclinical testing and mechanistic biological research. Disciplines within proteomics deployed in preclinical research are described as Tier I analysis, involving global protein mapping and protein profiling for differential expression, and Tier II proteomic analysis, including global methods for description of function, structure, interactions and post-translational modification of proteins. Proteomic platforms used in toxicoproteomics research are briefly reviewed. Preclinical toxicoproteomic studies with model liver and kidney toxicants are critically assessed for their contributions toward understanding pathophysiology and in biomarker discovery. Toxicoproteomics research conducted in other organs and tissues are briefly discussed as well. The final section suggests several key developments involving new approaches and research focus areas for the field of toxicoproteomics as a new tool for toxicological pathology. JF - EXS AU - Merrick, B Alex AU - Witzmann, Frank A AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, Durham, NC 27709, USA. merrick@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 367 EP - 400 VL - 99 SN - 1023-294X, 1023-294X KW - Index Medicus KW - Animals KW - Humans KW - Proteomics -- methods KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66838550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EXS&rft.atitle=The+role+of+toxicoproteomics+in+assessing+organ+specific+toxicity.&rft.au=Merrick%2C+B+Alex%3BWitzmann%2C+Frank+A&rft.aulast=Merrick&rft.aufirst=B&rft.date=2009-01-01&rft.volume=99&rft.issue=&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=EXS&rft.issn=1023294X&rft_id=info:doi/ LA 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Oct;37(2):225-34 [6814950] Toxicol Lett. 1989 Mar;46(1-3):125-39 [2650019] Toxicol Appl Pharmacol. 1990 May;103(3):463-73 [2339419] Clin Chem. 1994 Jul;40(7 Pt 2):1363-7 [8013120] Drug Metab Rev. 1995;27(1-2):147-77 [7641574] Electrophoresis. 1995 Jul;16(7):1273-83 [7498176] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Minocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae. AN - 66832769; 19153345 AB - Drug hypersensitivity syndrome (DHS) is a severe, multisystem adverse drug reaction that may occur following the use of numerous medications, including anticonvulsants, sulfonamides, and minocycline hydrochloride. Long-term autoimmune sequelae of DHS have been reported, including hypothyroidism. A 15-year-old female adolescent developed DHS 4 weeks after starting minocycline therapy for acne vulgaris. Seven weeks later she developed autoimmune hyperthyroidism (Graves disease), and 7 months after discontinuing minocycline therapy she developed autoimmune type 1 diabetes mellitus. In addition, she developed elevated titers of several markers of systemic autoimmune disease, including antinuclear, anti-Sjögren syndrome A, and anti-Smith antibodies. Minocycline-associated DHS may be associated with multiple autoimmune sequelae, including thyroid disease, type 1 diabetes mellitus, and elevated markers of systemic autoimmunity. Long-term follow-up is needed in patients with DHS to determine the natural history of DHS-associated sequelae. JF - Archives of dermatology AU - Brown, Rebecca J AU - Rother, Kristina I AU - Artman, Henry AU - Mercurio, Mary Gail AU - Wang, Roger AU - Looney, R John AU - Cowen, Edward W AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Rockville, Maryland, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 63 EP - 66 VL - 145 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Minocycline KW - FYY3R43WGO KW - Abridged Index Medicus KW - Index Medicus KW - Graves Disease -- chemically induced KW - Acne Vulgaris -- drug therapy KW - Humans KW - Diabetes Mellitus, Type 1 -- chemically induced KW - Adolescent KW - Female KW - Anti-Bacterial Agents -- therapeutic use KW - Drug Hypersensitivity -- etiology KW - Anti-Bacterial Agents -- adverse effects KW - Autoimmune Diseases -- chemically induced KW - Minocycline -- adverse effects KW - Minocycline -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66832769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Minocycline-induced+drug+hypersensitivity+syndrome+followed+by+multiple+autoimmune+sequelae.&rft.au=Brown%2C+Rebecca+J%3BRother%2C+Kristina+I%3BArtman%2C+Henry%3BMercurio%2C+Mary+Gail%3BWang%2C+Roger%3BLooney%2C+R+John%3BCowen%2C+Edward+W&rft.aulast=Brown&rft.aufirst=Rebecca&rft.date=2009-01-01&rft.volume=145&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=1538-3652&rft_id=info:doi/10.1001%2Farchdermatol.2008.521 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2009-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Pediatr. 1999 Oct;11(5):447-56 [10555598] Br J Dermatol. 2007 Sep;157(3):540-6 [17596147] Arch Intern Med. 2002 May 27;162(10):1190-2 [12020192] Diabetes Care. 2002 Dec;25(12):2302-7 [12453977] Arch Dermatol. 2004 Feb;140(2):183-8 [14967790] Arch Dermatol. 2004 Feb;140(2):226-30 [14967800] Diabet Med. 2004 Oct;21(10):1156-7 [15384968] J Invest Dermatol. 1986 Apr;86(4):449-53 [3755739] Clin Pharmacol Ther. 1992 Jan;51(1):56-67 [1732077] Biochem Pharmacol. 1992 Sep 25;44(6):1165-70 [1417938] Antimicrob Agents Chemother. 1996 Apr;40(4):934-40 [8849255] Diabetes. 1997 Jan;46(1):143-9 [8971095] Arthritis Rheum. 2004 Dec 15;51(6):1030-44 [15593352] Toxicology. 2005 Apr 15;209(2):165-7 [15767030] Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9 [15743917] J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S14-7 [16427984] Exp Clin Endocrinol Diabetes. 2006 Jan;114(1):35-8 [16450315] Clin Rheumatol. 2006 Mar;25(2):240-5 [16247581] Pharmacogenet Genomics. 2006 Apr;16(4):297-306 [16538176] Diabetes Care. 2006 May;29(5):1179-80 [16644665] Br J Dermatol. 2006 Aug;155(2):422-8 [16882184] Allergol Int. 2006 Mar;55(1):1-8 [17075280] Br J Dermatol. 2007 May;156(5):1005-9 [17408394] Pediatr Dermatol. 2007 May-Jun;24(3):246-9 [17542873] Curr Opin Allergy Clin Immunol. 2007 Aug;7(4):317-23 [17620823] JAMA. 2001 Mar 7;285(9):1153-4 [11231743] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archdermatol.2008.521 ER - TY - JOUR T1 - Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan. AN - 66830468; 18647964 AB - Screening of the oral cavity and dental care was suggested as mandatory preventive measures of osteonecrosis of the jaw (ONJ) in patients receiving bisphosphonates (BPs). We investigated the occurrence of ONJ before and after implementation of dental preventive measures when starting BP therapy. Since April 2005, 154 consecutive patients treated with BPs (POST-Group) have undergone a baseline mouth assessment (dental visit +/- orthopantomography of the jaws) to detect potential dental conditions and dental care if required. A retrospective review was also conducted of all consecutive cancer patients with bone metastases (PRE-Group) and treated for the first time with BPs from January 1999 to April 2005 in our clinic without receiving any preventive measure. Incidence proportion and incidence rate (IR) were used to estimate the incidence of ONJ. Among the study population (966 patients; male/female=179/787), 73% had breast cancer. 25% of patients were given zoledronic acid (ZOL), 62% pamidronate (PAM), 8% PAM followed by ZOL and 5% clodronate. ONJ was observed in 28 patients (2.9%); we observed a reduction in the incidence of ONJ from 3.2% to 1.3%, when comparing-pre and post-implementation of preventive measures programme. Considering the patients exposed to ZOL, the performance of a dental examination and the application of preventive measures led to a sustained reduction in ONJ IR (7.8% in the PRE-Group versus 1.7% in the POST-Group; P=0.016), with an IR ratio of 0.30 (95% confidence interval 0.03-1.26). ONJ is a manageable and preventable condition. Our data confirm that the application of preventive measures can significantly reduce the incidence of ONJ in cancer patients receiving BPs therapy. Dental exams combined to the identification of patients at risk in cooperation with the Dental Team can improve outcomes and increase the number of ONJ-free patients. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Ripamonti, C I AU - Maniezzo, M AU - Campa, T AU - Fagnoni, E AU - Brunelli, C AU - Saibene, G AU - Bareggi, C AU - Ascani, L AU - Cislaghi, E AD - Palliative Care Unit (Pain Therapy and Rehabilitation), IRCCS Foundation, National Cancer Institute of Milan, Milan, Italy. carla.ripamonti@istitutotumori.mi.it Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 137 EP - 145 VL - 20 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Index Medicus KW - Young Adult KW - Humans KW - Retrospective Studies KW - Academies and Institutes KW - Aged KW - Antineoplastic Agents -- adverse effects KW - Aged, 80 and over KW - Adult KW - Imidazoles -- therapeutic use KW - Incidence KW - Middle Aged KW - Italy -- epidemiology KW - Antineoplastic Agents -- therapeutic use KW - Female KW - Male KW - Diphosphonates -- therapeutic use KW - Neoplasms -- drug therapy KW - Osteonecrosis -- prevention & control KW - Bone Neoplasms -- epidemiology KW - Diphosphonates -- adverse effects KW - Osteonecrosis -- epidemiology KW - Jaw Diseases -- prevention & control KW - Neoplasms -- epidemiology KW - Osteonecrosis -- chemically induced KW - Neoplasms -- pathology KW - Bone Neoplasms -- drug therapy KW - Jaw Diseases -- chemically induced KW - Jaw Diseases -- epidemiology KW - Dental Prophylaxis -- utilization KW - Bone Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66830468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Decreased+occurrence+of+osteonecrosis+of+the+jaw+after+implementation+of+dental+preventive+measures+in+solid+tumour+patients+with+bone+metastases+treated+with+bisphosphonates.+The+experience+of+the+National+Cancer+Institute+of+Milan.&rft.au=Ripamonti%2C+C+I%3BManiezzo%2C+M%3BCampa%2C+T%3BFagnoni%2C+E%3BBrunelli%2C+C%3BSaibene%2C+G%3BBareggi%2C+C%3BAscani%2C+L%3BCislaghi%2C+E&rft.aulast=Ripamonti&rft.aufirst=C&rft.date=2009-01-01&rft.volume=20&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=1569-8041&rft_id=info:doi/10.1093%2Fannonc%2Fmdn526 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-19 N1 - Date created - 2009-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annonc/mdn526 ER - TY - JOUR T1 - Curing of yeast [URE3] prion by the Hsp40 cochaperone Ydj1p is mediated by Hsp70. AN - 66814114; 19015537 AB - [URE3] is a prion of the yeast Ure2 protein. Hsp40 is a cochaperone that regulates Hsp70 chaperone activity. When overexpressed, the Hsp40 Ydj1p cures yeast of [URE3], but the Hsp40 Sis1p does not. On the basis of biochemical data Ydj1p has been proposed to cure [URE3] by binding soluble Ure2p and preventing it from joining prion aggregates. Here, we mutagenized Ydj1p and find that disrupting substrate binding, dimerization, membrane association, or ability to transfer substrate to Hsp70 had little or no effect on curing. J-domain point mutations that disrupt functional interactions of Ydj1p with Hsp70 abolished curing, and the J domain alone cured [URE3]. Consistent with heterologous J domains possessing similar Hsp70 regulatory activity, the Sis1p J domain also cured [URE3]. We further show that Ydj1p is not essential for [URE3] propagation and that depletion of Ure2p is lethal in cells lacking Ydj1p. Our data imply that curing of [URE3] by overproduced Ydj1p does not involve direct interaction of Ydj1p with Ure2p but rather works through regulation of Hsp70 through a specific J-protein/Hsp70 interaction. JF - Genetics AU - Sharma, Deepak AU - Stanley, Robert F AU - Masison, Daniel C AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0851, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 129 EP - 137 VL - 181 IS - 1 SN - 0016-6731, 0016-6731 KW - HSP40 Heat-Shock Proteins KW - 0 KW - HSP70 Heat-Shock Proteins KW - Heat-Shock Proteins KW - Mutant Proteins KW - Prions KW - SIS1 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - YDJ1 protein, S cerevisiae KW - 139874-78-5 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - URE2 protein, S cerevisiae KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Microbial Viability KW - Mutant Proteins -- metabolism KW - Mutation -- genetics KW - Spores, Fungal -- cytology KW - Protein Structure, Tertiary KW - Prenylation KW - Protein Multimerization KW - Heat-Shock Proteins -- chemistry KW - Saccharomyces cerevisiae Proteins -- metabolism KW - HSP70 Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - HSP40 Heat-Shock Proteins -- chemistry KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Prions -- metabolism KW - HSP40 Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66814114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Curing+of+yeast+%5BURE3%5D+prion+by+the+Hsp40+cochaperone+Ydj1p+is+mediated+by+Hsp70.&rft.au=Sharma%2C+Deepak%3BStanley%2C+Robert+F%3BMasison%2C+Daniel+C&rft.aulast=Sharma&rft.aufirst=Deepak&rft.date=2009-01-01&rft.volume=181&rft.issue=1&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/10.1534%2Fgenetics.108.098699 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Plant Cell. 2000 Apr;12(4):457-60 [10760235] Mol Biol Cell. 2003 Mar;14(3):1172-81 [12631732] Curr Biol. 2000 Nov 16;10(22):1443-6 [11102806] EMBO J. 2001 May 15;20(10):2435-42 [11350932] Curr Microbiol. 2001 Jul;43(1):7-10 [11375656] Mol Cell Biol. 2001 Oct;21(20):7035-46 [11564886] Mol Cell Biol. 2002 Jun;22(11):3590-8 [11997496] Genetics. 2002 Nov;162(3):1045-53 [12454054] Genetics. 2003 Feb;163(2):495-506 [12618389] J Biol Chem. 2003 Nov 7;278(45):44457-66 [12941935] Structure. 2003 Dec;11(12):1475-83 [14656432] Mol Cell Biol. 2004 May;24(9):3928-37 [15082786] J Biol Chem. 2004 Oct 22;279(43):44376-83 [15302880] Genetics. 1989 May;122(1):19-27 [2659436] Methods Enzymol. 1991;194:281-301 [2005793] Methods Enzymol. 1991;194:3-21 [2005794] J Cell Biol. 1991 Aug;114(4):609-21 [1869583] J Biol Chem. 1992 Sep 15;267(26):18890-5 [1527016] Cell. 1992 Dec 24;71(7):1143-55 [1473150] Science. 1995 Oct 6;270(5233):93-5 [7569955] J Biol Chem. 1996 Apr 19;271(16):9347-54 [8621599] Mol Cell Biol. 1996 Sep;16(9):4773-81 [8756635] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12503-8 [9356479] Cell. 1998 Jul 10;94(1):73-82 [9674429] J Biol Chem. 1998 Oct 23;273(43):27824-30 [9774392] Protein Sci. 1999 Jan;8(1):203-14 [10210198] J Biol Chem. 1999 Oct 22;274(43):30534-9 [10521435] J Biol Chem. 2005 Jan 7;280(1):695-702 [15496404] Biochem J. 2005 Mar 15;386(Pt 3):453-60 [15500443] EMBO J. 2005 Sep 7;24(17):3082-92 [16096644] Cell. 2006 May 5;125(3):443-51 [16678092] Genetics. 2006 Jun;173(2):611-20 [16582428] J Biol Chem. 2007 Apr 20;282(16):11931-40 [17324933] Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7163-8 [17438278] Mol Biol Cell. 2007 Jun;18(6):2149-54 [17392510] Nat Rev Microbiol. 2007 Aug;5(8):611-8 [17632572] EMBO J. 2007 Aug 22;26(16):3794-803 [17673909] Proc Natl Acad Sci U S A. 2008 May 20;105(20):7206-11 [18480252] J Biol Chem. 2008 Jun 6;283(23):15732-9 [18400756] Mol Cell Biol. 2008 Jul;28(13):4434-44 [18443039] Genetics. 2008 Jul;179(3):1301-11 [18562668] J Mol Biol. 2008 Oct 31;383(1):155-66 [18723025] Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16596-601 [18955697] Mol Cell Biol. 2000 Dec;20(23):8916-22 [11073991] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1534/genetics.108.098699 ER - TY - JOUR T1 - Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. AN - 66811257; 19139015 AB - The increased molecular understanding of cancerous growth may now afford the opportunity to develop novel therapies targeting specific dysregulated molecular mechanisms contributing to the progression of each cancer type. In this regard, the aberrant activation of Akt/mammalian target of rapamycin (mTOR) pathway is a frequent event in head and neck squamous cell carcinomas (HNSCC), thus representing a potential molecular target for the treatment of HNSCC patients. The ability to translate this emerging body of information into effective therapeutic strategies, however, has been hampered by the limited availability of animal models for oral malignancies. Here, we show that the administration in the drinking water to mice of 4-nitroquinoline-1 oxide, a DNA adduct-forming agent that serves as a surrogate of tobacco exposure, leads to the progressive appearance of preneoplastic and tumoral lesions in the tongue and oral mucosa, with 100% incidence after only 16 weeks of carcinogen exposure. Remarkably, many of these lesions evolve spontaneously into highly malignant SCCs few weeks after 4-nitroquinoline-1 oxide withdrawal. In this model, we have observed that the activation of the Akt-mTOR biochemical route represents an early event, which is already detectable in dysplastic lesions. Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs. Together, these findings support the contribution of the mTOR signaling pathway to HNSCC progression and provide a strong rationale for the early evaluation of mTOR inhibitors as a molecular-targeted strategy for HNSCC chemoprevention and treatment. JF - Cancer prevention research (Philadelphia, Pa.) AU - Czerninski, Rakefet AU - Amornphimoltham, Panomwat AU - Patel, Vyomesh AU - Molinolo, Alfredo A AU - Gutkind, J Silvio AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Building 30, Bethesda, MD 20892-4340, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 27 EP - 36 VL - 2 IS - 1 KW - Antibiotics, Antineoplastic KW - 0 KW - Carcinogens KW - 4-Nitroquinoline-1-oxide KW - 56-57-5 KW - Protein Kinases KW - EC 2.7.- KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - mTOR protein, mouse KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinogens -- toxicity KW - Disease Progression KW - Cell Transformation, Neoplastic -- drug effects KW - Mice KW - 4-Nitroquinoline-1-oxide -- toxicity KW - Signal Transduction -- drug effects KW - Mice, Inbred C57BL KW - Immunohistochemistry KW - Female KW - Protein Kinases -- biosynthesis KW - Carcinoma, Squamous Cell -- metabolism KW - Head and Neck Neoplasms -- pathology KW - Precancerous Conditions -- drug therapy KW - Precancerous Conditions -- metabolism KW - Head and Neck Neoplasms -- drug therapy KW - Precancerous Conditions -- pathology KW - Head and Neck Neoplasms -- metabolism KW - Antibiotics, Antineoplastic -- pharmacology KW - Carcinoma, Squamous Cell -- pathology KW - Protein Kinases -- drug effects KW - Sirolimus -- pharmacology KW - Carcinoma, Squamous Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66811257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Targeting+mammalian+target+of+rapamycin+by+rapamycin+prevents+tumor+progression+in+an+oral-specific+chemical+carcinogenesis+model.&rft.au=Czerninski%2C+Rakefet%3BAmornphimoltham%2C+Panomwat%3BPatel%2C+Vyomesh%3BMolinolo%2C+Alfredo+A%3BGutkind%2C+J+Silvio&rft.aulast=Czerninski&rft.aufirst=Rakefet&rft.date=2009-01-01&rft.volume=2&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-08-0147 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-18 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Cancer Prev Res (Phila). 2009 Jan;2(1):10-3 [19139012] Cancer Prev Res (Phila). 2009 Jan;2(1):7-9 [19139011] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-08-0147 ER - TY - JOUR T1 - Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice. AN - 66811177; 19139019 AB - Although inflammatory cytokines and obesity-associated serum proteins have been reported as biomarkers of colorectal adenoma risk in humans, little is known of biomarkers of response to interventions that attenuate tumorigenesis. Dietary navy beans and their fractions attenuate colon carcinogenesis in carcinogen-induced genetically obese mice. We hypothesized that this attenuation would be associated with changes in inflammatory cytokines and obesity-related serum proteins that may serve as measures of efficacy. ob/ob mice (n = 160) were injected with the carcinogen azoxymethane (AOM) to induce colon cancer and randomly placed on one of four diets (control, whole navy bean, bean residue fraction, or bean extract fraction) for 26 to 28 wk. Serum was analyzed for 14 inflammation- or obesity-related proteins, and colon RNA was analyzed for expression of 84 inflammation-associated genes. Six of 14 serum proteins were increased [i.e., interleukin (IL)-4, IL-5, IL-6, IL-10, IFN gamma, granulocyte macrophage colony-stimulating factor] in hyperplastic/dysplastic stages of colon carcinogenesis. Bean-fed mice had significantly higher monocyte chemoattractant protein-1 and lower IL-6 levels in serum. In colon mucosa, 55 of 84 inflammation-associated genes differed between AOM-induced and noninduced mice. Of the 55 AOM-induced genes, 5 were counteracted by bean diets, including IL-6 whose increase in expression levels was attenuated by bean diets in AOM-induced mice. In summary, IL-6 emerged as a serum protein that was increased in hyperplastic/dysplastic stages of colon carcinogenesis, but attenuated with bean-based diet in serum and colon mucosa. Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis. JF - Cancer prevention research (Philadelphia, Pa.) AU - Mentor-Marcel, Roycelynn A AU - Bobe, Gerd AU - Barrett, Kathleen G AU - Young, Matthew R AU - Albert, Paul S AU - Bennink, Maurice R AU - Lanza, Elaine AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA. marcelr@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 60 EP - 69 VL - 2 IS - 1 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Cytokines KW - Interleukin-6 KW - Plant Extracts KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Precancerous Conditions -- diet therapy KW - Azoxymethane -- toxicity KW - Mice, Obese KW - Carcinogens -- toxicity KW - Mice KW - Precancerous Conditions -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Obesity -- complications KW - Precancerous Conditions -- genetics KW - Interleukin-6 -- genetics KW - Biomarkers, Tumor -- analysis KW - Diet KW - Interleukin-6 -- biosynthesis KW - Male KW - Fabaceae -- chemistry KW - Phytotherapy KW - Cytokines -- genetics KW - Colonic Neoplasms -- genetics KW - Cytokines -- biosynthesis KW - Colonic Neoplasms -- diet therapy KW - Inflammation -- genetics KW - Inflammation -- metabolism KW - Cytokines -- metabolism KW - Colonic Neoplasms -- metabolism KW - Plant Extracts -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66811177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Inflammation-associated+serum+and+colon+markers+as+indicators+of+dietary+attenuation+of+colon+carcinogenesis+in+ob%2Fob+mice.&rft.au=Mentor-Marcel%2C+Roycelynn+A%3BBobe%2C+Gerd%3BBarrett%2C+Kathleen+G%3BYoung%2C+Matthew+R%3BAlbert%2C+Paul+S%3BBennink%2C+Maurice+R%3BLanza%2C+Elaine%3BColburn%2C+Nancy+H&rft.aulast=Mentor-Marcel&rft.aufirst=Roycelynn&rft.date=2009-01-01&rft.volume=2&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-08-0086 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-18 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2007 Jun;92(6):2240-7 [17374712] Endocrinology. 2007 Jan;148(1):241-51 [17038556] Obesity (Silver Spring). 2007 Aug;15(8):1988-95 [17712116] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2128-35 [17932361] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2150-4 [17932364] Environ Health Perspect. 2007 Oct;115(10):1467-73 [17938737] J Nutr. 2007 Nov;137(11):2391-8 [17951475] Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1153-8 [17726148] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2373-8 [18006926] J Clin Invest. 2007 Dec;117(12):3660-3 [18060028] Cancer Res. 2008 Jan 1;68(1):323-8 [18172326] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Trends Mol Med. 2008 Mar;14(3):109-19 [18261959] Nutr Cancer. 2008;60(3):373-81 [18444172] Curr Opin Genet Dev. 2008 Feb;18(1):3-10 [18325755] Proc Natl Acad Sci U S A. 2008 May 27;105(21):7534-9 [18490655] Cancer. 2000 May 15;88(10):2398-424 [10820364] Lancet. 2001 Feb 17;357(9255):539-45 [11229684] Oncogene. 2002 Jun 6;21(25):3949-60 [12037677] Gastroenterology. 2002 Jun;122(7):2011-25 [12055606] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Nutr Cancer. 2002;44(1):60-5 [12672642] J Nutr. 2004 Oct;134(10):2673-7 [15465765] Physiol Rev. 1979 Jul;59(3):719-809 [379887] Endocrinology. 1980 Sep;107(3):671-6 [6249569] Science. 1993 Jan 1;259(5091):87-91 [7678183] J Nutr. 1993 Nov;123(11):1939-51 [8229312] Nutr Cancer. 1997;27(2):206-9 [9121951] J Clin Invest. 1997 Sep 1;100(5):1174-9 [9276734] J Nutr. 1997 Dec;127(12):2328-33 [9405582] J Clin Invest. 1998 Feb 15;101(4):746-54 [9466968] J Clin Endocrinol Metab. 1998 Mar;83(3):847-50 [9506738] Anticancer Res. 2004 Sep-Oct;24(5A):3049-55 [15517915] J Biol Chem. 2005 Mar 4;280(9):8260-5 [15613481] Cancer Res. 2005 Jun 1;65(11):4673-82 [15930285] Int J Cancer. 2005 Oct 10;116(6):949-56 [15856455] Obes Res. 2005 Aug;13(8):1311-20 [16129712] J Clin Endocrinol Metab. 2005 Oct;90(10):5834-40 [16091493] J Lipid Res. 2005 Nov;46(11):2347-55 [16150820] Eur J Cancer. 2005 Nov;41(16):2502-12 [16199153] Nat Clin Pract Oncol. 2005 Feb;2(2):90-7; quiz 1 p following 113 [16264881] Am J Clin Nutr. 2006 Feb;83(2):461S-465S [16470013] J Nutr Biochem. 2006 Mar;17(3):145-56 [16426829] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):389-94 [16492934] Proteomics. 2006 May;6(9):2844-52 [16596712] Br J Cancer. 2006 Jun 19;94(12):1898-905 [16755300] J Nutr. 2006 Jul;136(7):1896-903 [16772456] Obesity (Silver Spring). 2006 May;14(5):799-811 [16855189] Int J Obes (Lond). 2006 Sep;30(9):1347-55 [16534530] Mutat Res. 2007 Sep 1;622(1-2):103-16 [17574631] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-08-0086 ER - TY - JOUR T1 - Genetic signature for human risk assessment: lessons from trichloroethylene. AN - 66807296; 19031419 AB - Trichloroethylene (TCE), an organic solvent commonly used for metal degreasing and as a chemical additive, is a significant environmental contaminant that poses health concerns in humans. The US Environmental Protection Agency (EPA) is currently revising the 2001 TCE human risk assessment draft. The next draft is expected to be ready in 2008. TCE metabolites are detectable in humans and carry varying potencies for induction of cancers in animals. Genomic mechanisms have been explored in animals and humans to link TCE to carcinogenesis. DNA analysis provides an opportunity for detection of unique genetic alterations representing a signature of TCE exposure. These alterations can arise from genotoxic and nongenotoxic pathways at multiple points throughout tumorigenesis. Although fixation of alterations may require several stages of selection and modification, the spectra can be specific to TCE. Only a fraction of these alterations eventually lead to tumor formation and some contribute to tumor progression. Genetic events in two major TCE target organs are reviewed, including the VHL gene in kidney, and the Ras gene and genome-wide hypomethylation in liver. Attempts to identify a genetic signature of TCE exposure are challenged by inconsistent findings, lack of evidence of promutagenic lesions, biological relevance of specific genomic changes, and likelihood of coexposures. For human risk assessment, genome-wide screening is useful and is possible with the development of new DNA-sequencing technologies. Genetic screening for preneoplastic and tumor tissues from high-risk population is proposed to exclude the noise of passenger mutations and genetic polymorphisms. JF - Environmental and molecular mutagenesis AU - Shiao, Yih-Horng AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. shiao@mail.ncifcrf.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 68 EP - 77 VL - 50 IS - 1 KW - Trichloroethylene KW - 290YE8AR51 KW - Von Hippel-Lindau Tumor Suppressor Protein KW - EC 2.3.2.27 KW - VHL protein, human KW - EC 6.3.2.- KW - Index Medicus KW - United States KW - Kidney Neoplasms -- genetics KW - United States Environmental Protection Agency KW - Kidney Neoplasms -- chemically induced KW - Humans KW - Von Hippel-Lindau Tumor Suppressor Protein -- genetics KW - Environmental Exposure KW - Mutation KW - Risk Assessment KW - Trichloroethylene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66807296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Genetic+signature+for+human+risk+assessment%3A+lessons+from+trichloroethylene.&rft.au=Shiao%2C+Yih-Horng&rft.aulast=Shiao&rft.aufirst=Yih-Horng&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20432 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Genet. 2008 Mar;24(3):133-41 [18262675] Environ Health Perspect. 2000 May;108 Suppl 2:177-200 [10807551] Environ Health Perspect. 2000 May;108 Suppl 2:215-23 [10807553] Environ Health Perspect. 2000 Jul;108(7):579-88 [10905993] Ann N Y Acad Sci. 2000;919:79-85 [11083100] Science. 2001 Feb 16;291(5507):1304-51 [11181995] Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1583-8 [11171994] Nature. 2001 Feb 15;409(6822):860-921 [11237011] Curr Opin Neurol. 2001 Dec;14(6):695-703 [11723376] Toxicol Appl Pharmacol. 2002 Jul 1;182(1):55-65 [12127263] Nat Genet. 2002 Dec;32(4):614-21 [12415268] Nature. 2002 Dec 5;420(6915):520-62 [12466850] Science. 2003 Apr 18;300(5618):489-92 [12702876] Lancet. 2003 Jun 14;361(9374):2059-67 [12814730] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8424-9 [12826609] Cancer Res. 2003 Sep 1;63(17):5320-8 [14500363] Curr Med Chem. 2003 Nov;10(22):2461-70 [14529485] Hum Mutat. 2004 Jan;23(1):40-6 [14695531] Toxicology. 2004 Mar 1;196(1-2):127-36 [15036762] IARC Sci Publ. 2004;(157):247-70 [15055300] Nature. 2004 Apr 1;428(6982):493-521 [15057822] Toxicol Lett. 2004 Jun 15;151(1):301-10 [15177666] Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:40-8 [15209402] Nature. 1975 Mar 20;254(5497):261-2 [1113893] Annu Rev Genet. 1986;20:201-30 [3545059] Science. 1990 Sep 14;249(4974):1288-90 [1697983] Science. 1991 Nov 15;254(5034):1001-3 [1948068] J Biol Chem. 1992 Jan 5;267(1):166-72 [1730583] Carcinogenesis. 1994 Oct;15(10):2255-61 [7955063] Mutagenesis. 1994 Sep;9(5):429-37 [7837977] Environ Health Perspect. 1994 Sep;102 Suppl 3:57-61 [7843138] Carcinogenesis. 1995 Mar;16(3):495-500 [7697804] Cancer Lett. 1995 Jun 29;93(1):17-48 [7600541] Nat Med. 1995 Aug;1(8):822-6 [7585187] Regul Toxicol Pharmacol. 1996 Feb;23(1 Pt 1):2-13 [8628915] Science. 1996 Oct 18;274(5286):430-2 [8832894] Cancer Lett. 1996 Nov 29;108(2):257-61 [8973603] IARC Monogr Eval Carcinog Risks Hum. 1995;63:33-477 [9139128] Arch Toxicol. 1997;71(5):332-5 [9137812] Mutat Res. 1997 Apr 24;390(1-2):51-7 [9150752] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9102-7 [9256442] Chem Biol Interact. 1997 Sep 12;106(2):109-21 [9366897] Chem Res Toxicol. 1998 Sep;11(9):1082-8 [9760283] J Natl Cancer Inst. 1998 Nov 18;90(22):1720-3 [9827526] J Natl Cancer Inst. 1999 May 19;91(10):854-61 [10340905] Proc R Soc Med. 1965 May;58:295-300 [14283879] Cell. 2004 Dec 17;119(6):847-60 [15607980] Cell. 2004 Dec 17;119(6):861-72 [15607981] Pharmacogenomics. 2005 Jun;6(4):373-82 [16004555] Hum Mutat. 2005 Sep;26(3):184-91 [16086365] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] Bull World Health Organ. 2005 Oct;83(10):792-5 [16283057] Cancer Res. 2006 Mar 1;66(5):2576-83 [16510575] Genetics. 2006 Aug;173(4):2187-98 [16783027] Environ Health Perspect. 2006 Sep;114(9):1457-63 [16966105] Environ Health Perspect. 2006 Sep;114(9):1471-8 [16966107] Science. 2006 Oct 13;314(5797):268-74 [16959974] Hum Mutat. 2007 Feb;28(2):143-9 [17024664] Nature. 2007 Mar 8;446(7132):153-8 [17344846] World J Gastroenterol. 2007 Apr 28;13(16):2271-82 [17511024] Cancer Genomics Proteomics. 2007 May-Jun;4(3):111-9 [17878515] Cancer Cell. 2007 Oct;12(4):303-12 [17936556] Front Biosci. 2008;13:71-84 [17981529] Oncogene. 2008 Jan 10;27(3):404-8 [17621273] Environ Mol Mutagen. 2008 Mar;49(2):142-54 [17973308] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20432 ER - TY - JOUR T1 - Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use. AN - 66806238; 19124692 AB - In ecological momentary assessment (EMA), participants electronically report their activities and moods in their daily environments in real time, enabling a truly prospective approach to the study of acute precipitants of behavioral events. Ecological momentary assessment has greatly enhanced the study of tobacco addiction, but its use has rarely been attempted in individuals with cocaine or heroin addiction. To prospectively monitor the acute daily life precipitants of craving for and use of cocaine and heroin. Cohort study. A volunteer sample of 114 cocaine- and heroin-abusing outpatients who were being treated with methadone provided EMA data on handheld electronic devices for 14 918 person-days (mean, 130.9; range, 6-189 days per participant). Of these outpatients, a total of 102 (63 men, 39 women) provided acute precraving and/or preuse data and were thus included in the present analyses. Changes in reports of mood and exposure to 12 putative drug-use triggers at random intervals during the 5 hours preceding each self-reported episode of drug craving or use, analyzed via repeated-measures logistic regression (generalized linear mixed models). During the 5 hours preceding cocaine use or heroin craving, most of the 12 putative triggers showed linear increases. Cocaine use was most robustly associated with increases in participants reporting that they "saw [the] drug" (P < .001), were "tempted to use out of the blue" (P < .001), "wanted to see what would happen if I used" (P < .001), and were in a good mood (P < .001). Heroin craving was most robustly associated with increases in reports of feeling sad (P < .001) or angry (P = .01). Cocaine craving and heroin use showed few reliable associations with any of the putative triggers assessed. These findings confirm that polydrug-abusing individuals can provide behavioral data in their daily environments using handheld electronic devices and that those data can reveal orderly patterns, including prospectively detectable harbingers of craving and use, which may differ across drugs. JF - Archives of general psychiatry AU - Epstein, David H AU - Willner-Reid, Jessica AU - Vahabzadeh, Massoud AU - Mezghanni, Mustapha AU - Lin, Jia-Ling AU - Preston, Kenzie L AD - National Institute on Drug Abuse Intramural Research Program, Treatment Section, Clinical Pharmacology and Therapeutics Branch, Baltimore, MD 21224, USA. depstein@intra.nida.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 88 EP - 94 VL - 66 IS - 1 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Methadone -- therapeutic use KW - Combined Modality Therapy KW - Humans KW - Counseling KW - Recurrence KW - Ambulatory Care KW - Prospective Studies KW - Token Economy KW - Adult KW - Narcotics -- therapeutic use KW - Middle Aged KW - Female KW - Male KW - Social Environment KW - Substance Withdrawal Syndrome -- rehabilitation KW - Motivation KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Heroin Dependence -- rehabilitation KW - Substance Withdrawal Syndrome -- psychology KW - Affect KW - Computers, Handheld KW - Heroin Dependence -- psychology KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66806238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+and+neuroscience&rft.atitle=EEG+and+cerebral+blood+flow+velocity+abnormalities+in+chronic+cocaine+users.&rft.au=Copersino%2C+Marc+L%3BHerning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean-Lud%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2009-01-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+and+neuroscience&rft.issn=15500594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2009-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addiction. 2000 Jun;95(6):889-900 [10946438] Drug Alcohol Depend. 1998 Nov 1;52(3):183-92 [9839144] J Subst Abuse Treat. 2001 Sep;21(2):77-87 [11551736] Psychol Addict Behav. 2002 Sep;16(3):205-11 [12236455] J Abnorm Psychol. 2002 Nov;111(4):531-45 [12428767] Psychol Addict Behav. 2003 Mar;17(1):73-82 [12665084] Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20 [12402102] Psychopharmacology (Berl). 2003 Jul;168(1-2):31-41 [12721778] J Clin Psychol. 2004 Feb;60(2):179-88 [14724925] Psychol Rev. 2004 Jan;111(1):33-51 [14756584] J Consult Clin Psychol. 2004 Apr;72(2):192-201 [15065954] J Consult Clin Psychol. 1990 Apr;58(2):175-81 [2335634] Addict Behav. 1991;16(1-2):41-9 [2048457] J Consult Clin Psychol. 1996 Apr;64(2):366-79 [8871421] J Consult Clin Psychol. 1997 Feb;65(1):178-83 [9103747] Drug Alcohol Depend. 2005 Jun 1;78(3):275-81 [15893158] J Subst Abuse Treat. 2006 Mar;30(2):105-11 [16490673] Drug Alcohol Depend. 2006 Dec 1;85(3):221-35 [16730923] Schizophr Res. 2008 Jan;98(1-3):312-7 [17920245] Psychol Sci. 2000 Nov;11(6):446-53 [11202488] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archgenpsychiatry.2008.509 ER - TY - JOUR T1 - Jupiter to earth: a statin helps people with normal LDL-C and high hs-CRP, but what does it mean? AN - 66802173; 19122109 AB - The JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) (N Engl J Med 2008; 359:2195-2207) compared rosuvastatin (Crestor) 20 mg daily vs placebo in apparently healthy people who had levels of low-density lipoprotein cholesterol (LDL-C) lower than 130 mg/dL but elevated levels (>or= 2 mg/L) of high-sensitivity C-reactive protein (hs-CRP). Rosuvastatin treatment lowered LDL-C levels by 50% and hs-CRP levels by 37%, accompanied by a 44% relative risk reduction in the composite end point of unstable angina, revascularization, and confirmed death from cardiovascular causes. In absolute terms, 95 people had to be treated over 2 years to prevent one event. There was, however, a higher incidence of diabetes in the rosuvastatin group. JF - Cleveland Clinic journal of medicine AU - Shishehbor, Mehdi H AU - Hazen, Stanley L AD - National Institutes of Health CTSA-KL2 Scholar, Department of Interventional Cardiology, Heart and Vascular Institute, Cleveland Clinic , Cleveland, OH 44195, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 37 EP - 44 VL - 76 IS - 1 KW - Cholesterol, LDL KW - 0 KW - Fluorobenzenes KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Pyrimidines KW - Sulfonamides KW - Rosuvastatin Calcium KW - 83MVU38M7Q KW - C-Reactive Protein KW - 9007-41-4 KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Female KW - Pyrimidines -- adverse effects KW - Cholesterol, LDL -- blood KW - Sulfonamides -- adverse effects KW - Pyrimidines -- therapeutic use KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Fluorobenzenes -- adverse effects KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use KW - Fluorobenzenes -- therapeutic use KW - Sulfonamides -- therapeutic use KW - C-Reactive Protein -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66802173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cleveland+Clinic+journal+of+medicine&rft.atitle=Jupiter+to+earth%3A+a+statin+helps+people+with+normal+LDL-C+and+high+hs-CRP%2C+but+what+does+it+mean%3F&rft.au=Shishehbor%2C+Mehdi+H%3BHazen%2C+Stanley+L&rft.aulast=Shishehbor&rft.aufirst=Mehdi&rft.date=2009-01-01&rft.volume=76&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Cleveland+Clinic+journal+of+medicine&rft.issn=1939-2869&rft_id=info:doi/10.3949%2Fccjm.75a.08105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-24 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Cardiol. 2001 Mar 8;87(5A):28B-32B [11256847] JAMA. 2001 Apr 4;285(13):1711-8 [11277825] Circulation. 2001 Apr 3;103(13):1813-8 [11282915] JAMA. 2001 Jul 4;286(1):64-70 [11434828] Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1712-9 [11701455] Int J Clin Pract. 2002 Jan-Feb;56(1):53-6 [11831837] JAMA. 2002 Jun 26;287(24):3215-22 [12076217] Eur Heart J. 2002 Dec;23(24):1931-7 [12473255] Circulation. 2003 Jan 28;107(3):391-7 [12551861] Circulation. 2003 Jan 28;107(3):499-511 [12551878] JAMA. 2003 Apr 2;289(13):1675-80 [12672736] Cleve Clin J Med. 2003 Jul;70(7):634-40 [12882386] Circulation. 2003 Jul 29;108(4):426-31 [12860913] Curr Probl Cardiol. 2003 May;28(5):317-47 [14614445] JAMA. 2004 Mar 3;291(9):1071-80 [14996776] Curr Atheroscler Rep. 2004 May;6(3):243-50 [15068750] N Engl J Med. 2004 Apr 1;350(14):1387-97 [15070788] N Engl J Med. 2004 Apr 8;350(15):1495-504 [15007110] N Engl J Med. 2004 Apr 8;350(15):1562-4 [15007111] Circulation. 2001 Jan 16;103(2):276-83 [11208689] Circulation. 2004 Jul 13;110(2):227-39 [15249516] JAMA. 2004 Sep 15;292(11):1307-16 [15337732] Expert Opin Drug Saf. 2004 Nov;3(6):547-57 [15500414] Lancet. 1996 Nov 16;348(9038):1339-42 [8918276] N Engl J Med. 1997 Apr 3;336(14):973-9 [9077376] Circulation. 1998 May 26;97(20):2007-11 [9610529] JAMA. 1998 May 27;279(20):1615-22 [9613910] Circulation. 1998 Aug 25;98(8):731-3 [9727541] N Engl J Med. 1999 Jul 8;341(2):70-6 [10395630] Circulation. 1999 Jul 20;100(3):230-5 [10411845] Am J Cardiol. 2004 Nov 1;94(9):1140-6 [15518608] N Engl J Med. 2005 Jan 6;352(1):20-8 [15635109] N Engl J Med. 2005 Jan 6;352(1):29-38 [15635110] N Engl J Med. 2005 Apr 7;352(14):1425-35 [15755765] Circ Res. 2005 Apr 15;96(7):714-6 [15774855] JAMA. 2005 May 11;293(18):2245-56 [15886380] Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1102-11 [15790935] Circulation. 2005 Jul 5;112(1):25-31 [15983251] N Engl J Med. 2005 Jul 7;353(1):93-6; author reply 93-6 [16003832] Circulation. 2005 Aug 16;112(7):1016-23 [16087790] Am J Cardiol. 2005 Sep 5;96(5A):24F-33F [16126020] Lancet. 2005 Oct 8;366(9493):1267-78 [16214597] J Am Coll Cardiol. 2005 Oct 18;46(8):1405-10 [16226162] J Am Coll Cardiol. 2005 Nov 15;46(10):1855-62 [16286171] JAMA. 2005 Nov 16;294(19):2437-45 [16287954] Am J Cardiol. 2006 Apr 17;97(8A):44C-51C [16581328] Am J Cardiol. 2006 Apr 17;97(8A):82C-85C [16581334] JAMA. 2006 Apr 5;295(13):1556-65 [16533939] Cleve Clin J Med. 2006 Aug;73(8):760-6 [16913201] Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):134-40 [17068284] Eur Heart J. 2007 Mar;28(6):664-72 [17242008] J Am Coll Cardiol. 2007 May 1;49(17):1753-62 [17466224] J Am Coll Cardiol. 2007 May 29;49(21):2129-38 [17531663] JAMA. 2008 Mar 19;299(11):1265-76 [18349088] J Am Coll Cardiol. 2008 Apr 29;51(17):1653-62 [18436117] J Am Coll Cardiol. 2008 Jul 1;52(1):24-32 [18582631] N Engl J Med. 2008 Aug 14;359(7):760; author reply 761 [18703482] N Engl J Med. 2008 Oct 30;359(18):1897-908 [18971492] Arch Intern Med. 2002 Apr 22;162(8):867-9 [11966336] N Engl J Med. 2008 Nov 20;359(21):2280-2 [18997195] N Engl J Med. 2008 Nov 20;359(21):2195-207 [18997196] N Engl J Med. 2008 Oct 30;359(18):1953-5 [18971498] N Engl J Med. 1999 Dec 9;341(24):1853-4; author reply 1854-5 [10610464] Adv Intern Med. 2000;45:391-418 [10635056] N Engl J Med. 2000 Mar 23;342(12):836-43 [10733371] Curr Cardiol Rep. 2000 Jul;2(4):269-73 [10953258] Clin Chem. 2001 Mar;47(3):403-11 [11238289] JAMA. 2001 May 16;285(19):2481-5 [11368701] JAMA. 2001 May 16;285(19):2486-97 [11368702] N Engl J Med. 2001 Jun 28;344(26):1959-65 [11430324] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3949/ccjm.75a.08105 ER - TY - JOUR T1 - LX211 (voclosporin) suppresses experimental uveitis and inhibits human T cells. AN - 66795572; 18708627 AB - To test the therapeutic effectiveness of voclosporin against experimental autoimmune uveoretinitis (EAU) in rats and to evaluate its effect on human T cells. EAU was induced by immunization with a uveitogenic protein. Voclosporin administration, by subcutaneous injection, began on day (d) 0 or d7 after immunization. Treatment effectiveness was evaluated in vivo using clinical EAU scoring (d7-d13) and histopathologic evaluation of enucleated eyes after experimental termination. Rodent lymphocytes were harvested from lymph nodes on d14 for antigen-specific proliferation assays. The effect of voclosporin on human T-cell proliferation and cytokine secretion was examined in vitro. Voclosporin prevented EAU development in rats receiving medium and high preventive doses, whereas high-dose voclosporin administration effectively treated EAU. Lymphocytes from animals treated with voclosporin had decreased antigen-specific proliferation in vitro compared with lymphocytes from untreated animals. No evidence of abnormal ocular histopathology was found in the eyes from animals that received high doses of therapeutic voclosporin. Using human T cells, voclosporin inhibited human T-cell proliferation up to 100-fold. Furthermore, voclosporin treatment of human T cells significantly reduced pan T-cell effector responses. Voclosporin effectively suppressed uveoretinitis in an animal model that imitates the human inflammatory ocular disease by inhibiting lymphocyte proliferation. In addition, voclosporin effectively inhibited human T-cell proliferation and function in vitro. The authors report the first evidence supporting the application of voclosporin to treat intraocular inflammation. JF - Investigative ophthalmology & visual science AU - Cunningham, Matthew A AU - Austin, Bobbie Ann AU - Li, Zhuqing AU - Liu, Baoying AU - Yeh, Steven AU - Chan, Chi-Chao AU - Anglade, Eddy AU - Velagaleti, Poonam AU - Nussenblatt, Robert B AD - National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 249 EP - 255 VL - 50 IS - 1 KW - Cytokines KW - 0 KW - Eye Proteins KW - Immunosuppressive Agents KW - Retinol-Binding Proteins KW - interstitial retinol-binding protein KW - voclosporin KW - 2PN063X6B1 KW - Cyclosporine KW - 83HN0GTJ6D KW - Index Medicus KW - Rats KW - Lymphocyte Activation -- drug effects KW - Animals KW - Rats, Inbred Lew KW - Humans KW - Treatment Outcome KW - Injections, Subcutaneous KW - Cytokines -- metabolism KW - Male KW - Uveitis -- prevention & control KW - Autoimmune Diseases -- prevention & control KW - Retinitis -- immunology KW - Retinitis -- prevention & control KW - Disease Models, Animal KW - Uveitis -- immunology KW - Retinitis -- chemically induced KW - Immunosuppressive Agents -- pharmacology KW - Cyclosporine -- pharmacology KW - Autoimmune Diseases -- chemically induced KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- immunology KW - Uveitis -- chemically induced KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66795572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=LX211+%28voclosporin%29+suppresses+experimental+uveitis+and+inhibits+human+T+cells.&rft.au=Cunningham%2C+Matthew+A%3BAustin%2C+Bobbie+Ann%3BLi%2C+Zhuqing%3BLiu%2C+Baoying%3BYeh%2C+Steven%3BChan%2C+Chi-Chao%3BAnglade%2C+Eddy%3BVelagaleti%2C+Poonam%3BNussenblatt%2C+Robert+B&rft.aulast=Cunningham&rft.aufirst=Matthew&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=1552-5783&rft_id=info:doi/10.1167%2Fiovs.08-1891 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2009-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Nephrol Hypertens. 1995 Nov;4(6):472-7 [8591053] Ren Physiol Biochem. 1995 May-Jun;18(3):128-39 [7542793] Ophthalmology. 1998 Nov;105(11):2028-34 [9818601] Ophthalmology. 1999 Apr;106(4):723-8 [10201592] Clin Exp Immunol. 1999 Sep;117(3):455-61 [10469047] Transpl Int. 2005 May;17(12):767-71 [15827754] J Nephrol. 2005 Jul-Aug;18(4):453-7 [16245254] J Am Acad Dermatol. 2006 Mar;54(3):472-8 [16488299] Int Ophthalmol Clin. 2006 Fall;46(4):105-22 [17060797] Br J Ophthalmol. 2007 Feb;91(2):237-42 [16987901] Ophthalmology. 2007 May;114(5):1000-6 [17467532] Nat Med. 2007 Jun;13(6):711-8 [17496900] Expert Opin Investig Drugs. 2007 Oct;16(10):1525-40 [17922618] Bone Marrow Transplant. 2008 Feb;41(3):293-302 [17982500] J Exp Med. 2008 Apr 14;205(4):799-810 [18391061] Transplant Proc. 2001 Feb-Mar;33(1-2):1048-51 [11267185] J Ocul Pharmacol Ther. 2001 Apr;17(2):181-7 [11324985] J Rheumatol. 2002 Aug;29(8):1646-52 [12180723] J Heart Lung Transplant. 2003 Dec;22(12):1343-52 [14672749] Br J Ophthalmol. 2004 Mar;88(3):412-6 [14977779] Mol Interv. 2004 Apr;4(2):97-107 [15087483] Methods Mol Med. 2004;102:395-419 [15286397] Transplantation. 2004 Sep 15;78(5):681-5 [15371668] J Clin Invest. 1981 Apr;67(4):1228-31 [7204576] Invest Ophthalmol Vis Sci. 1985 Feb;26(2):226-32 [3871750] Biochemistry. 1985 Jan 29;24(3):787-93 [4039604] Transplant Proc. 1988 Jun;20(3 Suppl 4):122-7 [3381266] Invest Ophthalmol Vis Sci. 1988 Aug;29(8):1265-71 [2458329] J Ocul Pharmacol. 1985 Winter;1(4):369-82 [3880086] J Autoimmun. 1990 Jun;3(3):247-55 [2397018] Autoimmunity. 1990;8(1):43-51 [1717008] Photochem Photobiol. 1991 Dec;54(6):1057-60 [1775528] Biochem Pharmacol. 1992 Mar 3;43(5):1021-4 [1313235] Am J Ophthalmol. 1994 Jul 15;118(1):39-45 [8023874] Br J Ophthalmol. 1996 Sep;80(9):844-8 [8962842] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1167/iovs.08-1891 ER - TY - JOUR T1 - Enhancement of DNA tumor vaccine efficacy by gene gun-mediated codelivery of threshold amounts of plasmid-encoded helper antigen. AN - 66784619; 18832136 AB - Nucleic acid-based vaccines are effective in infectious disease models but have yielded disappointing results in tumor models when tumor-associated self-antigens are used. Incorporation of helper epitopes from foreign antigens into tumor vaccines might enhance the immunogenicity of DNA vaccines without increasing toxicity. However, generation of fusion constructs encoding both tumor and helper antigens may be difficult, and resulting proteins have unpredictable physical and immunologic properties. Furthermore, simultaneous production of equal amounts of highly immunogenic helper and weakly immunogenic tumor antigens in situ could favor development of responses against the helper antigen rather than the antigen of interest. We assessed the ability of 2 helper antigens (beta-galactosidase or fragment C of tetanus toxin) encoded by one plasmid to augment responses to a self-antigen (lymphoma-associated T-cell receptor) encoded by a separate plasmid after codelivery into skin by gene gun. This approach allowed adjustment of the relative ratios of helper and tumor antigen plasmids to optimize helper effects. Incorporation of threshold (minimally immunogenic) amounts of helper antigen plasmid into a DNA vaccine regimen dramatically increased T cell-dependent protective immunity initiated by plasmid-encoded tumor-associated T-cell receptor antigen. This simple strategy can easily be incorporated into future vaccine trials in experimental animals and possibly in humans. JF - Blood AU - Leitner, Wolfgang W AU - Baker, Matthew C AU - Berenberg, Thomas L AU - Lu, Michael C AU - Yannie, P Josef AU - Udey, Mark C AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 37 EP - 45 VL - 113 IS - 1 KW - Antigens, Neoplasm KW - 0 KW - Cancer Vaccines KW - Epitopes, T-Lymphocyte KW - Peptide Fragments KW - Receptors, Antigen, T-Cell, alpha-beta KW - Tetanus Toxin KW - Vaccines, DNA KW - tetanus toxin fragment C KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cell Line, Tumor KW - Epitopes, T-Lymphocyte -- immunology KW - Mice KW - Plasmids -- pharmacology KW - Epitopes, T-Lymphocyte -- genetics KW - Transfection KW - Antibody Formation -- immunology KW - Receptors, Antigen, T-Cell, alpha-beta -- immunology KW - Kidney -- cytology KW - Mice, Inbred C57BL KW - Antigens, Neoplasm -- immunology KW - Receptors, Antigen, T-Cell, alpha-beta -- genetics KW - T-Lymphocytes -- immunology KW - Female KW - Cricetinae KW - Tetanus Toxin -- immunology KW - Cancer Vaccines -- pharmacology KW - Vaccines, DNA -- immunology KW - Cancer Vaccines -- immunology KW - Peptide Fragments -- genetics KW - Vaccines, DNA -- pharmacology KW - Tetanus Toxin -- genetics KW - Biolistics -- methods KW - beta-Galactosidase -- genetics KW - Lymphoma, T-Cell -- immunology KW - beta-Galactosidase -- immunology KW - Peptide Fragments -- immunology KW - Lymphoma, T-Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66784619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Enhancement+of+DNA+tumor+vaccine+efficacy+by+gene+gun-mediated+codelivery+of+threshold+amounts+of+plasmid-encoded+helper+antigen.&rft.au=Leitner%2C+Wolfgang+W%3BBaker%2C+Matthew+C%3BBerenberg%2C+Thomas+L%3BLu%2C+Michael+C%3BYannie%2C+P+Josef%3BUdey%2C+Mark+C&rft.aulast=Leitner&rft.aufirst=Wolfgang&rft.date=2009-01-01&rft.volume=113&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-01-136267 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Feb 1;162(3):1749-55 [9973438] J Immunother. 1998 Nov;21(6):399-408 [9807734] J Virol. 1999 Mar;73(3):2280-7 [9971811] Vaccine. 1999 Feb 12;17(6):589-96 [10075166] Nat Med. 1999 Jul;5(7):823-7 [10395329] Vaccine. 2005 Jan 19;23(9):1114-25 [15629354] Med Hypotheses. 2006;67(1):71-4 [16513289] Intervirology. 2006;49(4):249-52 [16601357] Trends Mol Med. 2006 May;12(5):216-22 [16621717] J Clin Oncol. 2006 Jul 1;24(19):3107-12 [16754937] Adv Cancer Res. 2006;95:203-47 [16860659] Arch Virol. 2006 Nov;151(11):2133-48 [16791442] Clin Immunol. 2006 Nov;121(2):177-85 [16914381] J Virol. 2006 Dec;80(24):11991-7 [17005652] Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):540-9 [17255276] Scand J Immunol. 2007 Mar;65(3):240-8 [17309778] Vaccine. 2007 May 10;25(19):3731-41 [17350735] Curr Cancer Drug Targets. 2007 May;7(3):259-71 [17504123] Cancer Res. 2007 Jul 1;67(13):6459-67 [17616707] Cancer Res. 2007 Sep 1;67(17):7945-7 [17804699] Cancer Immunol Immunother. 2008 Nov;57(11):1635-45 [18386000] J Immunol. 2001 May 1;166(9):5366-73 [11313372] Vaccine. 1999 Dec 10;18(9-10):815-24 [10580194] Cancer Res. 2000 Jan 1;60(1):51-5 [10646851] J Immunol. 2000 Jul 15;165(2):869-77 [10878361] Curr Oncol Rep. 2000 Jan;2(1):38-47 [11122823] Vaccine. 2001 Mar 21;19(17-19):2647-56 [11257404] J Immunol. 2001 Aug 1;167(3):1558-65 [11466377] Curr Pharm Des. 2001 Nov;7(16):1641-67 [11562304] J Immunol. 2001 Nov 15;167(10):5549-57 [11698425] Dev Biol (Basel). 2000;104:181-5 [11713818] Cancer Res. 2002 Mar 15;62(6):1757-60 [11912151] Nat Med. 2003 Jan;9(1):33-9 [12496961] J Mol Med (Berl). 2003 Feb;81(2):71-86 [12601523] Hum Gene Ther. 2003 May 20;14(8):709-14 [12804135] J Immunol. 2003 Dec 15;171(12):6396-405 [14662838] J Immunol. 2004 Jan 15;172(2):929-36 [14707065] Expert Rev Vaccines. 2004 Apr;3(2):151-62 [15056041] Vaccine. 2004 May 7;22(15-16):2031-41 [15121317] Expert Opin Biol Ther. 2004 Jun;4(6):889-900 [15174971] DNA Cell Biol. 2004 Jun;23(6):395-402 [15231073] Nat Immunol. 2004 Nov;5(11):1143-8 [15475958] Infect Immun. 2004 Nov;72(11):6519-27 [15501783] J Immunol Methods. 1984 Mar 16;67(2):321-36 [6707474] J Immunol Methods. 1987 Apr 2;98(1):11-22 [2435806] J Immunol. 1988 Sep 15;141(6):2168-74 [3049800] Infect Immun. 1990 Apr;58(4):1004-9 [2318526] J Virol. 1996 Nov;70(11):7773-82 [8892898] J Immunol. 1997 Dec 1;159(11):5516-27 [9548492] J Immunol. 1997 Dec 15;159(12):6112-9 [9550412] J Exp Med. 1998 Sep 21;188(6):1075-82 [9743526] J Immunol. 1999 Feb 15;162(4):2251-8 [9973501] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-01-136267 ER - TY - JOUR T1 - Tumor vasculature-targeted delivery of tumor necrosis factor-alpha. AN - 66784051; 19090007 AB - Recently, considerable efforts have been directed toward antivascular therapy as a new modality to treat human cancers. However, targeting a therapeutic gene of interest to the tumor vasculature with minimal toxicity to other tissues remains the objective of antivascular gene therapy. Tumor necrosis factor-alpha (TNF-alpha) is a potent antivascular agent but has limited clinical utility because of significant systemic toxicity. At the maximum tolerated doses of systemic TNF-alpha, there is no meaningful antitumor activity. Hence, the objective of this study was to deliver TNF-alpha targeted to tumor vasculature by systemic delivery to examine its antitumor activity. A hybrid adeno-associated virus phage vector (AAVP) was used that targets tumor endothelium to express TNF-alpha (AAVP-TNF-alpha). The activity of AAVP-TNF-alpha was analyzed in various in vitro and in vivo settings using a human melanoma tumor model. In vitro, AAVP-TNF-alpha infection of human melanoma cells resulted in high levels of TNF-alpha expression. Systemic administration of targeted AAVP-TNF-alpha to melanoma xenografts in mice produced the specific delivery of virus to tumor vasculature. In contrast, the nontargeted vector did not target to tumor vasculature. Targeted AAVP delivery resulted in expression of TNF-alpha, induction of apoptosis in tumor vessels, and significant inhibition of tumor growth. No systemic toxicity to normal organs was observed. Targeted AAVP vectors can be used to deliver TNF-alpha specifically to tumor vasculature, potentially reducing its systemic toxicity. Because TNF-alpha is a promising antivascular agent that currently is limited by its toxicity, the current results suggest the potential for clinical translation of this strategy. JF - Cancer AU - Tandle, Anita AU - Hanna, Engy AU - Lorang, Dominique AU - Hajitou, Amin AU - Moya, Catherine A AU - Pasqualini, Renata AU - Arap, Wadih AU - Adem, Asha AU - Starker, Elizabeth AU - Hewitt, Stephen AU - Libutti, Steven K AD - Tumor Angiogenesis Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 128 EP - 139 VL - 115 IS - 1 SN - 0008-543X, 0008-543X KW - Tumor Necrosis Factor-alpha KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Melanoma, Experimental -- blood supply KW - Humans KW - Genetic Vectors KW - Transduction, Genetic KW - Gene Expression KW - Dependovirus -- genetics KW - Genetic Therapy -- methods KW - Mice, Nude KW - Mice KW - Cell Line, Tumor KW - Melanoma, Experimental -- therapy KW - Skin Neoplasms -- therapy KW - Skin Neoplasms -- blood supply KW - Melanoma -- therapy KW - Tumor Necrosis Factor-alpha -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Melanoma -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66784051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+disabilities+research+reviews&rft.atitle=Fetal+alcohol+spectrum+disorders%3A+when+science%2C+medicine%2C+public+policy%2C+and+laws+collide.&rft.au=Warren%2C+Kenneth+R%3BHewitt%2C+Brenda+G&rft.aulast=Warren&rft.aufirst=Kenneth&rft.date=2009-01-01&rft.volume=15&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Developmental+disabilities+research+reviews&rft.issn=1940-5529&rft_id=info:doi/10.1002%2Fddrr.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-10 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.24001 ER - TY - JOUR T1 - Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis. AN - 66781886; 19118017 AB - Transgenic mice that overexpress PKCalpha in the epidermis (K5-PKCalpha mice) exhibit acute CXCR2-mediated intraepidermal neutrophilic inflammation and a strong epidermal hyperplasia in response to application of 12-O-tetradecanoylphorbol-13-acetate (TPA). We now show that hyperplasia is independent of infiltrating neutrophils. Furthermore, when K5-PKCalpha mice were initiated with 7,12-dimethylbenz(a)anthracene (DMBA) and promoted with a low dose of TPA, 58% of K5-PKCalpha mice developed skin papillomas that progressed to carcinoma, whereas wild-type mice did not develop tumors. We confirmed that CXCR2 is expressed by keratinocytes and showed that transformation by oncogenic ras (a hallmark of DMBA initiation) or TPA exposure induced all CXCR2 ligands. Ras induction of CXCR2 ligands was mediated by autocrine activation of epidermal growth factor receptor and nuclear factor-kappaB, and potentiated by PKCalpha. Oncogenic ras also induced CXCR2 ligands in keratinocytes genetically ablated for CXCR2. However, ras transformed CXCR2 null keratinocytes formed only small skin tumors in orthotopic skin grafts to CXCR2 intact hosts, whereas transformed wild-type keratinocytes produced large tumors. In vitro, CXCR2 was essential for CXCR2 ligand-stimulated migration of ras-transformed keratinocytes and for ligand activation of the extracellular signal-regulated kinase (ERK) and Akt pathways. Both migration and activation of ERK and Akt were restored by CXCR2 reconstitution of CXCR2 null keratinocytes. Thus, activation of CXCR2 on ras-transformed keratinocytes has both promigratory and protumorigenic functions. The up-regulation of CXCR2 ligands after initiation by oncogenic ras and promotion with TPA in the mouse skin model provides a mechanism to stimulate migration by both autocrine and paracrine pathways and contribute to tumor development. JF - Cancer research AU - Cataisson, Christophe AU - Ohman, Rebecca AU - Patel, Gopal AU - Pearson, Andrea AU - Tsien, Margaret AU - Jay, Steve AU - Wright, Lisa AU - Hennings, Henry AU - Yuspa, Stuart H AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute/NIH, 37 Convent Drive, Bethesda, MD 20892-4264, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 319 EP - 328 VL - 69 IS - 1 KW - Ligands KW - 0 KW - Receptors, Interleukin-8B KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Protein Kinase C-alpha KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Neutrophils -- pathology KW - Enzyme Activation KW - HeLa Cells KW - Humans KW - Mice KW - Protein Kinase C-alpha -- metabolism KW - Hair Follicle -- enzymology KW - Protein Kinase C-alpha -- biosynthesis KW - Drug Eruptions -- pathology KW - Female KW - Male KW - Skin Neoplasms -- enzymology KW - Cell Transformation, Neoplastic -- pathology KW - Keratinocytes -- enzymology KW - Cell Transformation, Neoplastic -- metabolism KW - Skin Neoplasms -- pathology KW - Keratinocytes -- pathology KW - Keratinocytes -- metabolism KW - Skin Neoplasms -- metabolism KW - Receptors, Interleukin-8B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66781886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Inducible+cutaneous+inflammation+reveals+a+protumorigenic+role+for+keratinocyte+CXCR2+in+skin+carcinogenesis.&rft.au=Cataisson%2C+Christophe%3BOhman%2C+Rebecca%3BPatel%2C+Gopal%3BPearson%2C+Andrea%3BTsien%2C+Margaret%3BJay%2C+Steve%3BWright%2C+Lisa%3BHennings%2C+Henry%3BYuspa%2C+Stuart+H&rft.aulast=Cataisson&rft.aufirst=Christophe&rft.date=2009-01-01&rft.volume=69&rft.issue=1&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-2490 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-30 N1 - Date created - 2009-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1995 May 1;55(9):1883-93 [7728756] J Immunol. 2003 Sep 1;171(5):2703-13 [12928424] Cancer Res. 1997 Aug 1;57(15):3180-8 [9242447] Mol Carcinog. 1997 Sep;20(1):151-8 [9328446] J Biol Chem. 1998 Apr 24;273(17):10095-8 [9553055] J Dermatol Sci. 1998 May;17(1):1-7 [9651822] Genes Dev. 1999 Jun 1;13(11):1382-97 [10364156] Nat Med. 1999 Jul;5(7):828-31 [10395330] J Cell Sci. 1999 Oct;112 ( Pt 20):3497-506 [10504298] Oncol Rep. 1999 Nov-Dec;6(6):1405-10 [10523720] Cancer Res. 2004 Nov 1;64(21):7801-12 [15520186] Cancer Cell. 2004 Nov;6(5):447-58 [15542429] Semin Cancer Biol. 2005 Apr;15(2):75-83 [15652452] J Immunol. 2005 Feb 1;174(3):1686-92 [15661932] Adv Cancer Res. 2005;93:159-87 [15797447] J Immunol. 2005 Apr 15;174(8):5047-56 [15814736] Cancer Cell. 2005 May;7(5):411-23 [15894262] Cancer Immunol Immunother. 2006 Mar;55(3):237-45 [16047143] Nat Rev Cancer. 2006 Jan;6(1):24-37 [16397525] Eur J Cancer. 2006 Apr;42(6):735-44 [16527478] Cancer Res. 2006 Apr 15;66(8):4279-84 [16618752] Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12493-8 [16891410] J Clin Invest. 2006 Oct;116(10):2757-66 [16964312] J Biol Chem. 2006 Nov 24;281(47):35931-41 [16990258] J Cell Sci. 2007 Aug 15;120(Pt 16):2851-63 [17666434] Cancer Cell. 2008 Jan;13(1):23-35 [18167337] Neoplasia. 2008 Feb;10(2):131-9 [18283335] Nat Protoc. 2008;3(5):799-810 [18451788] J Biol Chem. 2008 Sep 26;283(39):26538-47 [18662984] J Exp Med. 2003 Sep 1;198(5):747-55 [12953094] J Immunol. 2004 Mar 1;172(5):2853-60 [14978086] Oncogene. 2004 Mar 11;23(10):1902-10 [14661063] J Cell Sci. 2004 Nov 1;117(Pt 23):5489-96 [15479720] Nature. 1986 Oct 30-Nov 5;323(6091):822-4 [2430189] J Cell Biol. 1989 Sep;109(3):1207-17 [2475508] Mol Carcinog. 1991;4(3):196-202 [2064725] Mol Carcinog. 1991;4(3):210-9 [2064727] Carcinogenesis. 1993 Nov;14(11):2353-8 [8242866] J Exp Med. 1995 Jan 1;181(1):435-40 [7807024] Cancer Res. 2000 Jan 15;60(2):226-9 [10667563] J Biol Chem. 2000 Mar 10;275(10):6868-75 [10702246] J Invest Dermatol. 2000 May;114(5):976-83 [10771480] Cancer Res. 2000 Jul 1;60(13):3328-32 [10910032] Oncogene. 2000 Jul 20;19(31):3477-86 [10918606] J Invest Dermatol. 2000 Aug;115(2):234-44 [10951241] Cytokine. 2001 Jun 7;14(5):253-63 [11444905] Int J Cancer. 2001 Sep 1;93(5):635-43 [11477572] Nature. 2003 Feb 6;421(6923):639-43 [12571598] Am J Pathol. 2003 Jul;163(1):303-12 [12819035] Science. 1995 Jul 14;269(5221):230-4 [7618084] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-2490 ER - TY - JOUR T1 - When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. AN - 66751231; 19001870 AB - The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, which results from a deficiency of the glycogen-degrading lysosomal hydrolase acid-alpha glucosidase (GAA). Skeletal and cardiac muscle are most severely affected by the progressive expansion of glycogen-filled lysosomes. In both humans and an animal model of the disease (GAA KO), skeletal muscle pathology also involves massive accumulation of autophagic vesicles and autophagic buildup in the core of myofibers, suggesting an induction of autophagy. Only when we suppressed autophagy in the skeletal muscle of the GAA KO mice did we realize that the excess of autophagy manifests as a functional deficiency. This failure of productive autophagy is responsible for the accumulation of potentially toxic aggregate-prone ubiquitinated proteins, which likely cause profound muscle damage in Pompe mice. Also, by generating muscle-specific autophagy-deficient wild-type mice, we were able to analyze the role of autophagy in healthy skeletal muscle. JF - Autophagy AU - Raben, Nina AU - Baum, Rebecca AU - Schreiner, Cynthia AU - Takikita, Shoichi AU - Mizushima, Noboru AU - Ralston, Evelyn AU - Plotz, Paul AD - Arthritis and Rheumatism Branch, NIAMS, NIH, Bethesda, MD 20892-1820, USA. rabenn@arb.niams.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 111 EP - 113 VL - 5 IS - 1 KW - alpha-Glucosidases KW - EC 3.2.1.20 KW - Index Medicus KW - Animals KW - Humans KW - alpha-Glucosidases -- metabolism KW - Organ Specificity KW - Mice KW - alpha-Glucosidases -- deficiency KW - Mice, Knockout KW - Muscle, Skeletal -- pathology KW - Muscle, Skeletal -- ultrastructure KW - Autophagy KW - Glycogen Storage Disease Type II -- enzymology KW - Muscle, Skeletal -- enzymology KW - Glycogen Storage Disease Type II -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66751231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autophagy&rft.atitle=When+more+is+less%3A+excess+and+deficiency+of+autophagy+coexist+in+skeletal+muscle+in+Pompe+disease.&rft.au=Raben%2C+Nina%3BBaum%2C+Rebecca%3BSchreiner%2C+Cynthia%3BTakikita%2C+Shoichi%3BMizushima%2C+Noboru%3BRalston%2C+Evelyn%3BPlotz%2C+Paul&rft.aulast=Raben&rft.aufirst=Nina&rft.date=2009-01-01&rft.volume=5&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Autophagy&rft.issn=1554-8635&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-12-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2000 Nov 1;19(21):5720-8 [11060023] Cell Struct Funct. 2002 Dec;27(6):421-9 [12576635] Dev Cell. 2004 Apr;6(4):463-77 [15068787] J Cell Biol. 1972 Jan;52(1):41-51 [4331300] Mol Ther. 2005 Jan;11(1):48-56 [15585405] J Cell Biol. 2005 May 9;169(3):425-34 [15866887] Ann Neurol. 2006 Apr;59(4):700-8 [16532490] Nature. 2006 Jun 15;441(7095):885-9 [16625204] Nature. 2006 Jun 15;441(7095):880-4 [16625205] Autophagy. 2005 Jul;1(2):84-91 [16874052] Pathol Res Pract. 2006;202(9):631-8 [16781826] Autophagy. 2006 Oct-Dec;2(4):318-20 [16874053] Mol Ther. 2006 Dec;14(6):831-9 [17008131] Curr Neurol Neurosci Rep. 2007 Jan;7(1):71-7 [17217857] Autophagy. 2007 Jul-Aug;3(4):323-8 [17387262] J Biol Chem. 2007 Aug 17;282(33):24131-45 [17580304] Autophagy. 2007 Nov-Dec;3(6):546-52 [17592248] Autophagy. 2007 Nov-Dec;3(6):542-5 [17611390] Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7 [17712358] Autophagy. 2008 Feb;4(2):151-75 [18188003] Nature. 2008 Feb 28;451(7182):1069-75 [18305538] Autophagy. 2008 Jul;4(5):727-30 [18437051] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction. AN - 66748479; 19096789 AB - Irradiation damage to salivary glands is a common iatrogenic consequence of treatment for head and neck cancers. The subsequent lack of saliva production leads to many functional and quality-of-life problems for affected patients and there is no effective conventional therapy. To address this problem, we developed an in vivo gene therapy strategy involving viral vector-mediated transfer of the aquaporin-1 cDNA to irradiation-damaged glands and successfully tested it in two pre-clinical models (irradiated rats and miniature pigs), as well as demonstrated its safety in a large toxicology and biodistribution study. Thereafter, a clinical research protocol was developed that has received approval from all required authorities in the United States. Patients are currently being enrolled in this study. JF - Handbook of experimental pharmacology AU - Baum, Bruce J AU - Zheng, Changyu AU - Cotrim, Ana P AU - McCullagh, Linda AU - Goldsmith, Corinne M AU - Brahim, Jaime S AU - Atkinson, Jane C AU - Turner, R James AU - Liu, Shuying AU - Nikolov, Nikolay AU - Illei, Gabor G AD - Molecular Physiology and Therapeutics Branch and Clinical Research Core, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA. bbaum@dir.nidcr.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 403 EP - 418 IS - 190 SN - 0171-2004, 0171-2004 KW - AQP1 protein, human KW - 0 KW - Aquaporin 1 KW - 146410-94-8 KW - Index Medicus KW - Animals KW - Humans KW - Genetic Vectors KW - Clinical Trials as Topic KW - Disease Models, Animal KW - Research Design KW - Cell Line KW - Radiotherapy -- adverse effects KW - Adenoviridae -- genetics KW - Radiation Injuries -- genetics KW - Aquaporin 1 -- biosynthesis KW - Gene Transfer Techniques -- adverse effects KW - Xerostomia -- metabolism KW - Xerostomia -- therapy KW - Radiation Injuries -- metabolism KW - Xerostomia -- etiology KW - Salivary Glands -- radiation effects KW - Xerostomia -- genetics KW - Aquaporin 1 -- genetics KW - Genetic Therapy -- adverse effects KW - Radiation Injuries -- therapy KW - Genetic Therapy -- methods KW - Salivary Glands -- metabolism KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66748479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Aquaporin-1+gene+transfer+to+correct+radiation-induced+salivary+hypofunction.&rft.au=Baum%2C+Bruce+J%3BZheng%2C+Changyu%3BCotrim%2C+Ana+P%3BMcCullagh%2C+Linda%3BGoldsmith%2C+Corinne+M%3BBrahim%2C+Jaime+S%3BAtkinson%2C+Jane+C%3BTurner%2C+R+James%3BLiu%2C+Shuying%3BNikolov%2C+Nikolay%3BIllei%2C+Gabor+G&rft.aulast=Baum&rft.aufirst=Bruce&rft.date=2009-01-01&rft.volume=&rft.issue=190&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-79885-9_20 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3268-73 [9096382] Hum Gene Ther. 1996 Jun 10;7(9):1085-93 [8773510] Arch Oral Biol. 1998 Apr;43(4):297-303 [9839705] Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1510-6 [16029813] Ann N Y Acad Sci. 1999 Jun 18;875:294-300 [10415576] Radiat Res. 1999 Feb;151(2):150-8 [9952299] Hum Gene Ther. 2006 Nov;17(11):1122-33 [17069536] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103 Suppl:S66.e1-19 [17379158] Mol Ther. 2005 Mar;11(3):444-51 [15727941] Cancer Gene Ther. 1999 Nov-Dec;6(6):505-13 [10608347] Hum Gene Ther. 2002 Jan 1;13(1):15-63 [11779412] Int Rev Cytol. 2002;213:93-146 [11837896] Oral Dis. 2002 Jul;8(4):183-91 [12206399] Arch Otolaryngol Head Neck Surg. 2003 Feb;129(2):247-50 [12578459] Crit Rev Oral Biol Med. 2003;14(3):199-212 [12799323] Mol Genet Metab. 2003 Sep-Oct;80(1-2):148-58 [14567964] J Gene Med. 2004 Jan;6(1):55-63 [14716677] Ann N Y Acad Sci. 1993 Sep 20;694:17-23 [8105741] Am J Physiol. 1994 Jun;266(6 Pt 1):G1146-55 [8023944] Biochem Biophys Res Commun. 1998 May 29;246(3):584-8 [9618254] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/978-3-540-79885-9_20 ER - TY - JOUR T1 - A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells. AN - 66748438; 18996183 AB - Organisms exposed to ionizing radiation are mainly damaged by free radicals, which are generated by the radiolysis of water contained in the cells. Recently a significant reduction of tissue injury from irradiation damage was demonstrated by using MnSOD-plasmid/liposome treatments in the protection of murine lung. In this study we show that a new active recombinant human MnSOD (rMnSOD), easily administered in vivo, not only exerts the same radioprotective effect on normal cells and organisms as any MnSOD, but it is also radiosensitizing for tumor cells. In addition, we show how healthy animals, exposed to lethal doses of ionizing radiation and daily injections with rMnSOD, were protected from radiodamage and were still alive 30 days after the irradiation, while animals treated with only PBS solution, in the absence of rMnSOD, died after 7-8 days from the radiotreatments. The molecular analysis of all irradiated tissues revealed that the antiapoptotic AVEN gene appeared activated only in the animals treated in the presence of rMnSOD. The data suggest that rMnSOD deserves to be considered as a pharmaceutical tool for making radiotherapy more selective on cancer cells and to prevent and/or cure the accidental damage derived from exposure to ionizing radiation. JF - Free radical biology & medicine AU - Borrelli, Antonella AU - Schiattarella, Antonella AU - Mancini, Roberto AU - Morrica, Brunello AU - Cerciello, Vincenzo AU - Mormile, Maria AU - d'Alesio, Valentina AU - Bottalico, Laura AU - Morelli, Francesco AU - D'Armiento, Maria AU - D'Armiento, Francesco Paolo AU - Mancini, Aldo AD - Department of Molecular Biology and Biotherapy, National Cancer Institute of Naples, Italy. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 110 EP - 116 VL - 46 IS - 1 KW - AVEN protein, human KW - 0 KW - Adaptor Proteins, Signal Transducing KW - Apoptosis Regulatory Proteins KW - Free Radical Scavengers KW - Free Radicals KW - Membrane Proteins KW - Radiation-Sensitizing Agents KW - Recombinant Proteins KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - Free Radicals -- toxicity KW - Gene Expression -- drug effects KW - Neoplasms -- drug therapy KW - Animals KW - Radiation Injuries -- prevention & control KW - Humans KW - Apoptosis -- radiation effects KW - Cell Line, Tumor KW - Mice KW - Radiation Tolerance -- drug effects KW - Radiation-Sensitizing Agents -- therapeutic use KW - Neoplasms -- radiotherapy KW - Apoptosis -- drug effects KW - Lethal Dose 50 KW - Mice, Inbred C57BL KW - Female KW - Gene Expression -- radiation effects KW - Radiation, Ionizing KW - Fibroblasts -- drug effects KW - Recombinant Proteins -- pharmacology KW - Apoptosis Regulatory Proteins -- genetics KW - Superoxide Dismutase -- administration & dosage KW - Free Radical Scavengers -- administration & dosage KW - Adaptor Proteins, Signal Transducing -- biosynthesis KW - Apoptosis Regulatory Proteins -- radiation effects KW - Superoxide Dismutase -- pharmacology KW - Fibroblasts -- pathology KW - Apoptosis Regulatory Proteins -- metabolism KW - Membrane Proteins -- biosynthesis KW - Apoptosis Regulatory Proteins -- biosynthesis KW - Fibroblasts -- radiation effects KW - Free Radical Scavengers -- pharmacology KW - Recombinant Proteins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66748438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=A+recombinant+MnSOD+is+radioprotective+for+normal+cells+and+radiosensitizing+for+tumor+cells.&rft.au=Borrelli%2C+Antonella%3BSchiattarella%2C+Antonella%3BMancini%2C+Roberto%3BMorrica%2C+Brunello%3BCerciello%2C+Vincenzo%3BMormile%2C+Maria%3Bd%27Alesio%2C+Valentina%3BBottalico%2C+Laura%3BMorelli%2C+Francesco%3BD%27Armiento%2C+Maria%3BD%27Armiento%2C+Francesco+Paolo%3BMancini%2C+Aldo&rft.aulast=Borrelli&rft.aufirst=Antonella&rft.date=2009-01-01&rft.volume=46&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.10.030 ER - TY - JOUR T1 - Transitions in and out of alcohol use disorders: their associations with conditional changes in quality of life over a 3-year follow-up interval. AN - 66740000; 19042925 AB - The aim of this study was to investigate longitudinal changes in quality of life (QOL) as a function of transitions in alcohol use disorders (AUD) over a 3-year follow-up of a general US population sample. The analysis is based on individuals who drank alcohol in the year preceding the Wave 1 National Epidemiologic Survey on Alcohol and Related Conditions and were reinterviewed at Wave 2 (n = 22,245). Using multiple linear regression models, changes in SF-12 QOL were estimated as a function of DSM-IV AUD transitions, controlling for baseline QOL and multiple potential confounders. Onset and offset of AUD were strongly associated with changes in mental/psychological functioning, with significant decreases in mental component summary (NBMCS) scores among individuals who developed dependence and significant increases among those who achieved full and partial remission from dependence. The increases in overall NBMCS and its social functioning, role emotional and mental health components were equally great for abstinent and nonabstinent remission from dependence, but improvements in bodily pain and general health were associated with nonabstinent remission only. Onset of abuse was unrelated to changes in QOL, and the increase in NBMCS associated with nonabstinent remission from abuse only was slight. Individuals with abuse only or no AUD who stopped drinking had significant declines in QOL. These results suggest the possible importance of preventing and treating AUD for maintaining and/or improving QOL. They are also consistent with the sick quitter hypothesis and suggest that abuse is less a mental disorder than a maladaptive pattern of behavior. JF - Alcohol and alcoholism (Oxford, Oxfordshire) AU - Dawson, Deborah A AU - Li, Ting-Kai AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Biometry and Epidemiology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. ddawson@mail.nih.gov PY - 2009 SP - 84 EP - 92 VL - 44 IS - 1 KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Pain -- psychology KW - Health Status KW - Linear Models KW - Models, Statistical KW - Longitudinal Studies KW - Pain -- complications KW - Psychiatric Status Rating Scales KW - Adult KW - Health Surveys KW - Follow-Up Studies KW - Temperance KW - Adolescent KW - Female KW - Male KW - Alcoholism -- epidemiology KW - Quality of Life KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66740000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.atitle=Transitions+in+and+out+of+alcohol+use+disorders%3A+their+associations+with+conditional+changes+in+quality+of+life+over+a+3-year+follow-up+interval.&rft.au=Dawson%2C+Deborah+A%3BLi%2C+Ting-Kai%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2009-01-01&rft.volume=44&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.issn=1464-3502&rft_id=info:doi/10.1093%2Falcalc%2Fagn094 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 1995 Nov 15;274(19):1511-7 [7474219] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Alcohol Clin Exp Res. 1997 Aug;21(5):899-905 [9267541] Alcohol Alcohol. 1997 Jul-Aug;32(4):527-35 [9269861] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] J Subst Abuse. 1998;10(1):75-84 [9720008] Am J Drug Alcohol Abuse. 1998 Nov;24(4):685-94 [9849778] Am J Addict. 1999 Winter;8(1):44-54 [10189514] Alcohol Alcohol. 1999 Mar-Apr;34(2):183-92 [10344779] J Neurosurg. 2005 Mar;102(3):489-94 [15796384] Lancet. 2005 Feb 5-11;365(9458):519-30 [15705462] J Stud Alcohol. 1999 Sep;60(5):653-62 [10487735] J Stud Alcohol Suppl. 2005 Jul;(15):119-39; discussion 92-3 [16223064] J Ambul Care Manage. 2006 Jan-Mar;29(1):61-70 [16340620] Spine (Phila Pa 1976). 2006 Mar 15;31(6):639-43 [16540866] Drug Alcohol Rev. 2006 Nov;25(6):503-13 [17132570] J Stud Alcohol Drugs. 2007 Jan;68(1):36-47 [17149516] Addiction. 2007 Feb;102(2):257-63 [17222280] Ann Epidemiol. 2007 May;17(5 Suppl):S16-23 [17478320] Drug Alcohol Depend. 2008 Jan 1;92(1-3):27-36 [17706375] J Stud Alcohol Drugs. 2008 Nov;69(6):866-77 [18925345] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] Addiction. 1999 Jun;94(6):843-55 [10665074] Med Care. 2000 Nov;38(11):1141-50 [11078054] J Nurs Meas. 2001 Fall;9(2):151-61 [11696939] J Gen Intern Med. 2002 May;17(5):382-6 [12047737] J Stud Alcohol. 2002 Jul;63(4):397-403 [12160097] Ophthalmology. 2002 Oct;109(10):1793-8 [12359596] Am J Drug Alcohol Abuse. 2003 May;29(2):323-35 [12765209] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Am J Addict. 2003 May-Jun;12(3):198-210 [12851016] Alcohol Clin Exp Res. 2004 Jan;28(1):64-77 [14745303] Int J Rehabil Res. 2004 Jun;27(2):149-50 [15167113] Drug Alcohol Depend. 2004 Jun 11;74(3):223-34 [15194200] Aust N Z J Psychiatry. 2004 Oct;38(10):842-8 [15369544] Lancet. 1988 Dec 3;2(8623):1267-73 [2904004] Addiction. 1993 Aug;88(8):1079-90 [8401162] J Consult Clin Psychol. 1995 Feb;63(1):133-40 [7896978] Alcohol Alcohol. 1996 Nov;31(6):565-76 [9010547] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/alcalc/agn094 ER - TY - JOUR T1 - Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal. AN - 66736892; 18723835 AB - The mechanism by which chronic ethanol consumption reduces concentrations of long chain polyunsaturated (LCP) fatty acids (FA) in tissues of humans was investigated in alcohol-dependent (AD) men during early withdrawal and to a well-matched control group by fitting the concentration-time curves of d(5)-labeled n-3 FA from plasma and liver, which originated from an oral dose of d(5)-linolenic acid (d(5)-18:3n-3) ethyl ester to a compartmental model. Blood sampled over 168 h and a liver specimen obtained 96 h after isotope administration were analyzed for d(5)-18:3n-3, d(5)-20:5n-3, d(5)-22:5n-3, and d(5)-22:6n-3. Plasma 20:5n-3 and 22:5n-3 were lower in AD subjects, compared with controls (20:5n-3: -50%, 22:5n-3: -34%). Increased amounts of d(5)-18:3n-3 were directed toward synthesis of d(5)-20:5n-3 in AD subjects (P < .05). However, this effect was offset by larger amounts of 20:5n-3 lost from plasma (control: 2.0 vs. AD: 4.2 mg d(-1)). In livers of AD subjects, more d(5)-18:3n-3 and d(5)-22:5n-3 were utilized for synthesis of d(5)-20:5n-3 (+200%) and d(5)-22:6n-3 (+210%), respectively, than was predicted from plasma kinetics. Although, the potential to utilize linolenic acid for synthesis of LCP FA was greater in AD subjects compared with controls, heightened disappearance rates of 20:5n-3 reduced overall plasma concentrations of several endogenous n-3 LCP FA. JF - Journal of lipid research AU - Pawlosky, Robert J AU - Hibbeln, Joseph R AU - Herion, David AU - Kleiner, David E AU - Salem, Norman AD - Laboratory of Metabolic Control, National Cancer Institute NIH, Bethesda, MD, USA. bpawl@niaaa.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 154 EP - 161 VL - 50 IS - 1 SN - 0022-2275, 0022-2275 KW - Fatty Acids, Essential KW - 0 KW - Fatty Acids, Omega-3 KW - alpha-Linolenic Acid KW - 0RBV727H71 KW - Index Medicus KW - alpha-Linolenic Acid -- metabolism KW - Mass Spectrometry KW - Substance Withdrawal Syndrome -- metabolism KW - Area Under Curve KW - Humans KW - Adult KW - Biopsy KW - Substance Withdrawal Syndrome -- blood KW - Time Factors KW - Models, Biological KW - Male KW - Hepatocytes -- metabolism KW - Liver -- pathology KW - Fatty Acids, Omega-3 -- metabolism KW - Fatty Acids, Essential -- blood KW - Liver -- metabolism KW - Alcoholism -- metabolism KW - Fatty Acids, Essential -- metabolism KW - Fatty Acids, Omega-3 -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66736892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Compartmental+analysis+of+plasma+and+liver+n-3+essential+fatty+acids+in+alcohol-dependent+men+during+withdrawal.&rft.au=Pawlosky%2C+Robert+J%3BHibbeln%2C+Joseph+R%3BHerion%2C+David%3BKleiner%2C+David+E%3BSalem%2C+Norman&rft.aulast=Pawlosky&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=00222275&rft_id=info:doi/10.1194%2Fjlr.M800322-JLR200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-02 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1999 Sep;104(6):805-13 [10491416] Alcohol Clin Exp Res. 1999 Feb;23(2):311-7 [10069561] Hepatology. 2005 Jun;41(6):1313-21 [15915461] Alcohol Clin Exp Res. 2001 Aug;25(8):1231-7 [11505055] J Lipid Res. 2001 Aug;42(8):1257-65 [11483627] J Lipid Res. 2007 Apr;48(4):935-43 [17234605] Alcohol Clin Exp Res. 2001 Dec;25(12):1758-65 [11781509] Br J Nutr. 2002 Oct;88(4):355-63 [12323085] Biol Psychiatry. 2003 Mar 1;53(5):431-41 [12614996] Br J Nutr. 2003 Nov;90(5):993-4; discussion 994-5 [14667193] Fed Proc. 1972 Sep-Oct;31(5):1451-7 [5056171] Biol Psychiatry. 1978 Oct;13(5):551-65 [728507] Lipids. 1980 Apr;15(4):263-8 [7374380] Alcohol Clin Exp Res. 1983 Spring;7(2):220-6 [6408939] Alcohol Clin Exp Res. 1983 Fall;7(4):424-30 [6419631] Ann Nutr Metab. 1985;29(4):246-52 [4026205] J Lipid Res. 1985 Jul;26(7):806-18 [4040952] Eur J Clin Nutr. 1988 Sep;42(9):797-803 [2846266] Biomed Chromatogr. 1990 Nov;4(6):234-8 [2289046] Alcohol Alcohol. 1991;26(4):459-64 [1760057] Free Radic Biol Med. 1992;12(3):219-40 [1563648] J Intern Med. 1992 Apr;231(4):349-56 [1588258] J Am Coll Nutr. 1992 Jun;11(3):304-8 [1619182] Arch Gen Psychiatry. 1992 Aug;49(8):630-6 [1637253] Hepatology. 1992 Aug;16(2):448-53 [1639354] Am J Clin Nutr. 1992 Sep;56(3):467-74 [1503056] J Lipid Res. 1992 Nov;33(11):1711-7 [1464754] Alcohol Alcohol. 1993 May;28(3):287-95 [8352840] Gastroenterology. 1994 Jan;106(1):152-9 [8276177] J Clin Invest. 1994 Jan;93(1):450-4 [8282819] Hepatology. 1994 May;19(5):1229-40 [8175146] Alcohol Alcohol. 1994 Sep;29(5):493-502 [7811333] N Engl J Med. 1995 May 4;332(18):1198-203 [7700313] Am J Clin Nutr. 1995 Jun;61(6):1284-9 [7762532] Hepatology. 1996 Apr;23(4):872-80 [8666344] Circulation. 1996 Jul 1;94(1):19-25 [8964113] Am J Epidemiol. 1996 Aug 15;144(4):325-34 [8712189] J Biol Chem. 1999 Jan 1;274(1):471-7 [9867867] Alcohol. 2004 Aug;34(1):27-33 [15670662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1194/jlr.M800322-JLR200 ER - TY - JOUR T1 - Less is more, except when less is less: Studying joint effects. AN - 66734312; 18598750 AB - Most diseases are complex in that they are caused by the joint action of multiple factors, both genetic and environmental. Over the past few decades, the mathematical convenience of logistic regression has served to enshrine the multiplicative model, to the point where many epidemiologists believe that departure from additivity on a log scale implies that two factors interact in causing disease. Other terminology in epidemiology, where students are told that inequality of relative risks across levels of a second factor should be seen as "effect modification," reinforces an uncritical acceptance of multiplicative joint effect as the biologically meaningful no-interaction null. Our first task, when studying joint effects, is to understand the limitations of our definitions for "interaction," and recognize that what statisticians mean and what biologists might want to mean by interaction may not coincide. Joint effects are notoriously hard to identify and characterize, even when asking a simple and unsatisfying question, like whether two effects are log-additive. The rule of thumb for such efforts is that a factor-of-four sample size is needed, compared with that needed to demonstrate main effects of either genes or exposures. So strategies have been devised that focus on the most informative individuals, either through risk-based sampling for a cohort, or case-control sampling, extreme phenotype sampling, pooling, two-stage sampling, exposed-only, or case-only designs. These designs gain efficiency, but at a cost of flexibility in models for joint effects. A relatively new approach avoids population controls by genotyping case-parent triads. Because it requires parents, the method works best for diseases with onset early in life. With this design, the role of autosomal genetic variants is assessed by in effect treating the nontransmitted parental alleles as controls for affected offspring. Despite advantages for looking at genetic effects, the triad design faces limitations when examining joint effects of genetic and environmental factors. Because population-based controls are not included, main effects for exposures cannot be estimated, and consequently one only has access to inference related to a multiplicative null. We have proposed a hybrid approach that offers the best features of both case-parent and case-control designs. Through genotyping of parents of population-based controls and assuming Mendelian transmission, power is markedly enhanced. One can also estimate main effects for exposures and now flexibly assess models for joint effects. JF - Genomics AU - Weinberg, C R AD - National Institute of Environmental Health Sciences, MD A3-03, P.O. Box 12233, Research Triangle Park, NC 27709, USA. weinber2@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 10 EP - 12 VL - 93 IS - 1 KW - Index Medicus KW - Genotype KW - Epidemiologic Methods KW - Humans KW - Case-Control Studies KW - Parents KW - Research Design KW - Models, Genetic KW - Environmental Exposure KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66734312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Less+is+more%2C+except+when+less+is+less%3A+Studying+joint+effects.&rft.au=Weinberg%2C+C+R&rft.aulast=Weinberg&rft.aufirst=C&rft.date=2009-01-01&rft.volume=93&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=1089-8646&rft_id=info:doi/10.1016%2Fj.ygeno.2008.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biometrics. 1999 Sep;55(3):718-26 [11314998] Eur J Hum Genet. 2004 Nov;12(11):964-70 [15340361] Am J Epidemiol. 1982 Jan;115(1):119-28 [7055123] Am J Epidemiol. 1986 Jan;123(1):162-73 [3940436] Am J Hum Genet. 1993 Mar;52(3):506-16 [8447318] Stat Med. 1994 Jan 30;13(2):153-62 [8122051] Am J Hum Genet. 1998 Apr;62(4):969-78 [9529360] Am J Epidemiol. 1998 Nov 1;148(9):893-901 [9801020] Am J Hum Genet. 1999 Jul;65(1):229-35 [10364536] Am J Hum Genet. 2005 Oct;77(4):627-36 [16175508] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ygeno.2008.06.002 ER - TY - JOUR T1 - Age at menarche and weight concerns in relation to smoking trajectory and dependence among adolescent girls enrolled in a smoking cessation trial. AN - 66724378; 18940275 AB - Many girls adopt dieting and other practices (i.e. cigarette smoking) to control weight during puberty. This analysis explored the relationship between age at menarche and onset of daily smoking, and whether this relationship was influenced by weight concerns among treatment seeking female adolescents. The sample consisted of 71 participants enrolled in a smoking cessation trial (age 15.2+/-1.3 years; 74.7% European American, baseline BMI 24.7+/-5.4, age at menarche 11.7+/-1.3 years, Fagerström Test for Nicotine Dependence score 7.0+/-1.2). Over 60% of participants reported weight concerns at baseline, based on responses to the Eating Disorders module from the Diagnostic Interview for Children and Adolescents. Linear regression analyses revealed a significant association between age at menarche and age of onset of daily smoking (beta=0.18+/-0.09, p=0.038). Having weight concerns did not modify the relationships between age at menarche and smoking trajectory/severity or abstinence. Findings support previous research showing that early maturation represents a risk factor for substance use. Further study in larger samples that include non-treatment-seeking adolescent female smokers is warranted. JF - Addictive behaviors AU - Jaszyna-Gasior, Maria AU - Schroeder, Jennifer R AU - Thorner, Elissa D AU - Heishman, Stephen J AU - Collins, Charles C AU - Lo, Suzanne AU - Moolchan, Eric T AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Biomedical Research Center, Baltimore, Maryland 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 92 EP - 95 VL - 34 IS - 1 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Nicotine -- therapeutic use KW - Nicotinic Agonists -- therapeutic use KW - Humans KW - Child KW - Adolescent KW - Female KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- drug therapy KW - Body Weight -- drug effects KW - Menarche -- physiology KW - Feeding and Eating Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66724378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Age+at+menarche+and+weight+concerns+in+relation+to+smoking+trajectory+and+dependence+among+adolescent+girls+enrolled+in+a+smoking+cessation+trial.&rft.au=Jaszyna-Gasior%2C+Maria%3BSchroeder%2C+Jennifer+R%3BThorner%2C+Elissa+D%3BHeishman%2C+Stephen+J%3BCollins%2C+Charles+C%3BLo%2C+Suzanne%3BMoolchan%2C+Eric+T&rft.aulast=Jaszyna-Gasior&rft.aufirst=Maria&rft.date=2009-01-01&rft.volume=34&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=1873-6327&rft_id=info:doi/10.1016%2Fj.addbeh.2008.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-30 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addbeh.2008.08.001 ER - TY - JOUR T1 - Effect of indoor air pollution from biomass fuel use on argyrophilic nuclear organizer regions in buccal epithelial cells. AN - 66635939; 19888913 AB - This study investigated the effect of indoor air pollution from biomass-fuel use on the expression of argyrophilic nucleolar organizer regions (AgNORs), an indicator of ribosome biosynthesis, in epithelial cells of oral mucosa. AgNORs were evaluated using cytochemical staining in 62 nonsmoking indian women (median age, 34 years), who cooked exclusively with biomass, and 55 age-matched women, who were from a similar neighborhood and cooked with relatively clean liquefied petroleum gas (LPG). Concentrations of particulate pollutants in indoor air were measured using a real-time aerosol monitor. Compared to the LPG-using controls, biomass-fuel users showed a remarkably increased number of AgNOR dots per nucleus (6.08 +/-2.26 vs 3.16 +/-0.86, p < 0.001), AgNOR size (0.85 +/-0.19 vs 0.53 +/-0.15 mum2, p < 0.001), and percentage of AgNOR-occupied nuclear area (4.88 +/-1.49 vs 1.75 +/-0.13%, p < 0.001). Biomass-using households had 2 to 4 times more particulate pollutants than that of LPG-using households. The changes in AgNOR expression were positively associated with PM10 and PM2.5 levels in indoor air after controlling for potential confounders such as age, kitchen location, and family income. Thus, biomass smoke appears to be a risk factor for abnormal cell growth via upregulation of ribosome biogenesis. JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer AU - Mondal, Nandan K AU - Dutta, Anindita AU - Banerjee, Anirban AU - Chakraborty, Sreeparna AU - Lahiri, Twisha AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2009 PY - 2009 DA - 2009 SP - 253 EP - 259 VL - 28 IS - 3 KW - Air Pollutants KW - 0 KW - Antigens, Nuclear KW - Smoke KW - nucleolar organizer region associated proteins KW - Index Medicus KW - Humans KW - Cooking KW - Adult KW - Silver Staining KW - Energy-Generating Resources KW - Female KW - Smoke -- adverse effects KW - Air Pollution, Indoor -- adverse effects KW - Air Pollution, Indoor -- analysis KW - Mouth Mucosa -- pathology KW - Antigens, Nuclear -- drug effects KW - Biomass KW - Nucleolus Organizer Region -- drug effects KW - Air Pollutants -- adverse effects KW - Mouth Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66635939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.atitle=Effect+of+indoor+air+pollution+from+biomass+fuel+use+on+argyrophilic+nuclear+organizer+regions+in+buccal+epithelial+cells.&rft.au=Mondal%2C+Nandan+K%3BDutta%2C+Anindita%3BBanerjee%2C+Anirban%3BChakraborty%2C+Sreeparna%3BLahiri%2C+Twisha%3BRay%2C+Manas+Ranjan&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2009-01-01&rft.volume=28&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.issn=2162-6537&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Natural Language Processing Versus Content-Based Image Analysis for Medical Document Retrieval AN - 57727688; 200903843 AB - One of the most significant recent advances in health information systems has been the shift from paper to electronic documents. While research on automatic text and image processing has taken separate paths, there is a growing need for joint efforts, particularly for electronic health records and biomedical literature databases. This work aims at comparing text-based versus image-based access to multimodal medical documents using state-of-the-art methods of processing text and image components. A collection of 180 medical documents containing an image accompanied by a short text describing it was divided into training and test sets. Content-based image analysis and natural language processing techniques are applied individually and combine for multimodal document analysis. The evaluation consists of an indexing task and a retrieval task based on the "gold standard" codes manually assigned to corpus documents. The performance of text-based and image-based access, as well as combined document features, is compared. Image analysis proves more adequate for both the indexing and retrieval of the images. In the indexing task, multimodal analysis outperforms both independent image and text analysis. This experiment shows that text describing images can be usefully analyzed in the framework of a hybrid text/image retrieval system. [Copyright 2009 Wiley Periodicals Inc.] JF - Journal of the American Society for Information Science and Technology AU - Neveol, Aurelie AU - Deserno, Thomas M AU - Darmoni, Stefan J AU - Guld, Mark Oliver AU - Aronson, Alan R AD - U.S. National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894 neveola@nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 123 EP - 134 PB - Wiley Subscription Services, Hoboken NJ VL - 60 IS - 1 SN - 1532-2882, 1532-2882 KW - Natural language processing KW - Text processing KW - Images KW - article KW - 13.14: INFORMATION STORAGE AND RETRIEVAL - SEARCHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57727688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.atitle=Natural+Language+Processing+Versus+Content-Based+Image+Analysis+for+Medical+Document+Retrieval&rft.au=Neveol%2C+Aurelie%3BDeserno%2C+Thomas+M%3BDarmoni%2C+Stefan+J%3BGuld%2C+Mark+Oliver%3BAronson%2C+Alan+R&rft.aulast=Neveol&rft.aufirst=Aurelie&rft.date=2009-01-01&rft.volume=60&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.issn=15322882&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Natural language processing; Text processing; Images ER - TY - JOUR T1 - Mapping the Health Research Landscape in Sub-Saharan Africa: A Study of Trends in Biomedical Publications AN - 57708320; 200905040 AB - The process of research begins with grant-writing and concludes with publication. According to a recent study, in resource-poor settings, in-country national research and publications change clinical practice. One way to promote the visibility of these publications is for them to be peer reviewed and indexed in MEDLINE/PubMed. This process is fundamental not only to scientific progress, but to promoting the widespread communication of novel discoveries from low- and middle-income countries to the rest of the world. Worldwide scientific publishing activity over the past decade indicates that most countries in Sub-Saharan Africa (SSA) have low levels of publication. In a recent analysis, 31 of the world's 193 countries produce 97.5% of the world's most cited papers. South Africa, at number 29, is the only Sub-Saharan African country on this list, but little is known about the comparative volume of publications among the different countries in SSA. This study examined authorship in MEDLINE-indexed journal publications by Sub-Saharan African first authors as one metric of high-quality health research output. MEDLINE is the bibliographic database of the National Library of Medicine (NLM) at the US National Institutes of Health. Publication trends over a decade were tracked with two key objectives in mind: to approximate the research publishing landscape in the region, with special attention paid to country-specific (i.e., national) journals and to contrast the publication volume of the most productive country in SSA with publishing practices of other comparable countries outside the region. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Hofman, Karen J AU - Kanyengo, Christine W AU - Rapp, Barbara A AU - Kotzin, Sheldon AD - The John E. Fogarty International Center, National Institutes of Health, 16 Center Drive, MSC 6705, Bethesda, MD 20892-6705 hofmank@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 41 EP - 44 PB - Medical Library Association, Chicago, IL VL - 97 IS - 1 SN - 1536-5050, 1536-5050 KW - Bibliometrics KW - SubSaharan Africa KW - Scholarly publishing KW - Medicine KW - article KW - 16.16: PUBLISHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57708320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Mapping+the+Health+Research+Landscape+in+Sub-Saharan+Africa%3A+A+Study+of+Trends+in+Biomedical+Publications&rft.au=Hofman%2C+Karen+J%3BKanyengo%2C+Christine+W%3BRapp%2C+Barbara+A%3BKotzin%2C+Sheldon&rft.aulast=Hofman&rft.aufirst=Karen&rft.date=2009-01-01&rft.volume=97&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Scholarly publishing; Bibliometrics; Medicine; SubSaharan Africa ER - TY - JOUR T1 - OBESITY AND BODY MASS INDEX (BMI) IN RELATION TO LIFE-STYLE AND PSYCHO-SOCIAL ASPECTS AN - 57314511; 200928517 AB - Obesity is increasing in middle-aged adults and the elderly. This multifactorial phenomenon may have different causes, such as incorrect nutritional and dietary habits, psycho-social aspects and sedentary life-style. It is becoming a serious problem, due also to the world's ageing society. The aim of this study is to provide preliminary results on BMI, life-style and psycho-social aspects in a sample of Italian subjects, which also assesses the relationship between obesity and psychological health. We hypothesize that obesity is related to many factors, such as life-style, behavioral, socio-economic, and psychological aspects. The sample was made up of 107 obese and non-obese subjects, aged 50-74. All participants were given a multidimensional assessment, which included anthropometric, psycho-social and life-style evaluation. As per the protocol a structured life-style questionnaire designed to gather information on anthropometric measurements, socio-economic factors, physical activity, smoking, alcohol and food intake. The Symptom Checklist-90 (SCL-90) for the evaluation of a broad range of psychological problems and symptoms of psychopathology; the Binge Eating Scale (BES) for the assessment of disorders in the eating habits were administered. BMI was associated with age and education, socio-economic status and smoking in both genders. Psychological factors for obesity differed between overweight men and women. In conclusion, obesity and non-obesity appear as two different entities in some aspects. The increase in the prevalence of obesity in elderly subjects could lead to disability and age-related diseases. For this reason, greater insight of the factors related to the development of obesity is required to develop treatment strategies weight-loss prevention programs. [Copyright Elsevier B.V.] JF - Archives of Gerontology and Geriatrics AU - Marcellini, F AU - Giuli, C AU - Papa, R AU - Tirabassi, G AU - Faloia, E AU - Boscaro, M AU - Polito, A AU - Ciarapica, D AU - Zaccaria, M AU - Mocchegiani, E AD - Center of Psycho-social Aspects of Aging, Scientific-Technological Area, INRCA (Italian National Institute on Aging), Via S. Margherita 5, 1-60124 Ancona, Italy f.marcellini@inrca.it Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 195 EP - 206 PB - Elsevier Ltd, The Netherlands VL - 49 SN - 0167-4943, 0167-4943 KW - Obesity Binge eating disorder Elderly Body mass index KW - Elderly people KW - Symptoms KW - Obesity KW - Socioeconomic factors KW - Body Mass Index KW - Psychological aspects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57314511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Gerontology+and+Geriatrics&rft.atitle=OBESITY+AND+BODY+MASS+INDEX+%28BMI%29+IN+RELATION+TO+LIFE-STYLE+AND+PSYCHO-SOCIAL+ASPECTS&rft.au=Marcellini%2C+F%3BGiuli%2C+C%3BPapa%2C+R%3BTirabassi%2C+G%3BFaloia%2C+E%3BBoscaro%2C+M%3BPolito%2C+A%3BCiarapica%2C+D%3BZaccaria%2C+M%3BMocchegiani%2C+E&rft.aulast=Marcellini&rft.aufirst=F&rft.date=2009-01-01&rft.volume=49&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Archives+of+Gerontology+and+Geriatrics&rft.issn=01674943&rft_id=info:doi/10.1016%2Fj.archger.2009.09.029 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Obesity; Body Mass Index; Psychological aspects; Symptoms; Elderly people; Socioeconomic factors DO - http://dx.doi.org/10.1016/j.archger.2009.09.029 ER - TY - JOUR T1 - Autism Spectrum Disorders and Childhood-Onset Schizophrenia: Clinical and Biological Contributions to a Relation Revisited AN - 57284482; 200904711 AB - Objective: To highlight emerging evidence for clinical and biological links between autism/pervasive developmental disorder (PDD) and schizophrenia, with particular attention to childhood-onset schizophrenia (COS). Method: Clinical, demographic, and brain developmental data from the National Institute of Mental Health (and other) COS studies and selected family, imaging, and genetic data from studies of autism, PDD, and schizophrenia were reviewed. Results: In the two large studies that have examined this systematically, COS is preceded by and comorbid with PDD in 30% to 50% of cases. Epidemiological and family studies find association between the disorders. Both disorders have evidence of accelerated trajectories of anatomic brain development at ages near disorder onset. A growing number of risk genes and/or rare small chromosomal variants (microdeletions or duplications) are shared by schizophrenia and autism. Conclusions: Biological risk does not closely follow DSM phenotypes, and core neurobiological processes are likely common for subsets of these two heterogeneous clinical groups. Long-term prospective follow-up of autistic populations and greater diagnostic distinction between schizophrenia spectrum and autism spectrum disorders in adult relatives are needed. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Rapoport, Judith AU - Chavez, Alex AU - Greenstein, Deanna AU - Addington, Anjene AU - Gogtay, Nitin AD - Child Psychiatry Branch, NIMH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 10 EP - 18 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 1 SN - 0890-8567, 0890-8567 KW - schizophrenia, childhood, autism, genetics, brain development KW - Schizophrenia KW - Brain KW - Phenotypes KW - Autism KW - Comorbidity KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57284482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Autism+Spectrum+Disorders+and+Childhood-Onset+Schizophrenia%3A+Clinical+and+Biological+Contributions+to+a+Relation+Revisited&rft.au=Rapoport%2C+Judith%3BChavez%2C+Alex%3BGreenstein%2C+Deanna%3BAddington%2C+Anjene%3BGogtay%2C+Nitin&rft.aulast=Rapoport&rft.aufirst=Judith&rft.date=2009-01-01&rft.volume=48&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31818b1c63 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Autism; Autistic spectrum disorders; Brain; Phenotypes; Comorbidity DO - http://dx.doi.org/10.1097/CHI.0b013e31818b1c63 ER - TY - JOUR T1 - Are Patterns of Health Behavior Associated With Cancer Screening? AN - 57283881; 200906941 AB - Purpose. This study investigates the relationship between patterns of health behaviors and the use of cancer-screening tests while controlling for sociodemographic and health system factors. Design. Cross-sectional analysis of the 2000 National Health Interview (NHIS). Setting. Nationally representative sample. Subjects. Adults 50 years and older. Measures. Use of cancer-screening tests, health behaviors, sociodemographic factors, and health system factors from self-reported responses from the NHIS. Sixteen health behavior patterns were identified based on lifestyle recommendations for physical activity, tobacco use, alcohol consumption, and fruit and vegetable consumption. Results. Health behavior patterns, age, educational attainment, usual source of care, and health insurance were significantly associated with the use of breast, cervical, and colorectal cancer screening (p < .05). Approximate R2 for the four models ranged from .067 for colorectal cancer screening in women to .122 for cervical cancer screening. Having a usual source of care was the strongest correlate of screening; the magnitude of associations for health behavior patterns and demographic variables and screening was similar and much smaller than those for usual source of care. Conclusion. These findings demonstrate relationships between patterns of multiple health behaviors and use of recommended cancer-screening tests, even when accounting for factors known to influence test use. This suggests potential for addressing cancer screening in the context of multiple behavior change interventions once barriers to health care access are removed. Adapted from the source document. JF - American Journal of Health Promotion AU - Meissner, Helen I AU - Yabroff, K Robin AU - Dodd, Kevin W AU - Leader, Amy E AU - Ballard-Barbash, Rachel AU - Berrigan, David AD - Division of Cancer Control and Population Sciences. National Cancer Institute, Executive Plaza North, Suite 4102, 6130 Executive Blvd, MSC 7331, Bethesda, MD 20892-7331 Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 168 EP - 175 PB - AJHP Inc, West Bloomfield MI VL - 23 IS - 3 SN - 0890-1171, 0890-1171 KW - Health Behavior, Pattern, Cancer, Screening, Colon, Breast, Lifestyle, Prevention Research KW - Screening KW - Prevention KW - Health care KW - Colorectal cancer KW - Cancer KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57283881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Are+Patterns+of+Health+Behavior+Associated+With+Cancer+Screening%3F&rft.au=Meissner%2C+Helen+I%3BYabroff%2C+K+Robin%3BDodd%2C+Kevin+W%3BLeader%2C+Amy+E%3BBallard-Barbash%2C+Rachel%3BBerrigan%2C+David&rft.aulast=Meissner&rft.aufirst=Helen&rft.date=2009-01-01&rft.volume=23&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHPED N1 - SubjectsTermNotLitGenreText - Health behaviour; Screening; Prevention; Cancer; Colorectal cancer; Health care ER - TY - JOUR T1 - Repetitive TMS combined with exposure therapy for PTSD: A preliminary study AN - 57282110; 200907151 AB - Treatment for anxiety and post-traumatic stress disorder (PTSD) includes exposure therapy and medications, but some patients are refractory. Few studies of repetitive transcranial magnetic stimulation (rTMS) for anxiety or PTSD exist. In this preliminary report, rTMS was combined with exposure therapy for PTSD. Nine subjects with chronic, treatment-refractory PTSD were studied in a placebo-controlled, crossover design of imaginal exposure therapy with rTMS (1 Hz) versus sham. PTSD symptoms, serum and 24 h urine were obtained and analyzed. Effect sizes for PTSD symptoms were determined using Cohen's d. Active rTMS showed a larger effect size of improvement for hyperarousal symptoms compared to sham; 24-h urinary norepinephrine and serum T4 increased; serum prolactin decreased. Active rTMS with exposure may have symptomatic and physiological effects. Larger studies are needed to confirm these preliminary findings and verify whether rTMS plus exposure therapy has a role in the treatment of PTSD. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Osuch, Elizabeth A AU - Benson, Brenda E AU - Luckenbaugh, David A AU - Geraci, Marilla AU - Post, Robert M AU - McCann, Una AD - Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA, United States Elizabeth.osuch@lhsc.on.ca Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 54 EP - 59 PB - Elsevier Ltd, The Netherlands VL - 23 IS - 1 SN - 0887-6185, 0887-6185 KW - Post-traumatic stress disorder (PTSD) Transcranial magnetic stimulation (TMS) Psychological desensitization Psychological therapies Extinction KW - Transcranial magnetic stimulation KW - Posttraumatic stress disorder KW - Anxiety KW - Exposure therapy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Repetitive+TMS+combined+with+exposure+therapy+for+PTSD%3A+A+preliminary+study&rft.au=Osuch%2C+Elizabeth+A%3BBenson%2C+Brenda+E%3BLuckenbaugh%2C+David+A%3BGeraci%2C+Marilla%3BPost%2C+Robert+M%3BMcCann%2C+Una&rft.aulast=Osuch&rft.aufirst=Elizabeth&rft.date=2009-01-01&rft.volume=&rft.issue=190&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-79885-9_20 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Exposure therapy; Transcranial magnetic stimulation; Anxiety DO - http://dx.doi.org/10.1016/j.janxdis.2008.03.015 ER - TY - JOUR T1 - Sex Differences in WISC-III Profiles of Children with High-functioning Pervasive Developmental Disorders AN - 57281634; 200909488 AB - Using the Japanese version of the Wechsler Intelligence Scale for Children-Third Edition (WISC-III), 26 girls with high-functioning (IQ >= 70) pervasive developmental disorders (HFPDD) (mean age, 8.2 years) were compared with 116 boys with HFPDD (mean age, 9.0 years). Compared with the boys, the girls scored significantly higher on the Processing Speed index, Coding, and Symbol Search, but scored significantly lower on Block Design. Although both groups showed weakness on Comprehension in the verbal domain, the girls' subtest profile in the performance domain was relatively even and significantly different from the boys', which was characterized by a peak on Block Design. Such differences should be replicated, and possible behavioral, neurological, and genetic links to these sex differences should be clarified. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Koyama, Tomonori AU - Kamio, Yoko AU - Inada, Naoko AU - Kurita, Hiroshi AD - Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8553, Japan Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 135 EP - 141 PB - Springer, Dordrecht The Netherlands VL - 39 IS - 1 SN - 0162-3257, 0162-3257 KW - Intelligence KW - High functioning KW - Developmentally disabled children KW - Intelligence tests KW - Pervasive developmental disorders KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Sex+Differences+in+WISC-III+Profiles+of+Children+with+High-functioning+Pervasive+Developmental+Disorders&rft.au=Koyama%2C+Tomonori%3BKamio%2C+Yoko%3BInada%2C+Naoko%3BKurita%2C+Hiroshi&rft.aulast=Koyama&rft.aufirst=Tomonori&rft.date=2009-01-01&rft.volume=39&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0610-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Gender differences; Developmentally disabled children; Pervasive developmental disorders; High functioning; Intelligence tests; Intelligence DO - http://dx.doi.org/10.1007/s10803-008-0610-6 ER - TY - JOUR T1 - Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multicenter trial of buprenorphine-naloxone and clonidine in the NIDA clinical trials network drug and alcohol dependence AN - 57276955; 200907998 AB - Few studies in community settings have evaluated predictors, mediators, and moderators of treatment success for medically supervised opioid withdrawal treatment. This report presents new findings about these factors from a study of 344 opioid-dependent men and women prospectively randomized to either buprenorphine-naloxone or clonidine in an open-label 13-day medically supervised withdrawal study. Subjects were either inpatient or outpatient in community treatment settings; however not randomized by treatment setting. Medication type (buprenorphine-naloxone versus clonidine) was the single best predictor of treatment retention and treatment success, regardless of treatment setting. Compared to the outpatient setting, the inpatient setting was associated with higher abstinence rates but similar retention rates when adjusting for medication type. Early opioid withdrawal severity mediated the relationship between medication type and treatment outcome with buprenorphine-naloxone being superior to clonidine at relieving early withdrawal symptoms. Inpatient subjects on clonidine with lower withdrawal scores at baseline did better than those with higher withdrawal scores; inpatient subjects receiving buprenorphine-naloxone did better with higher withdrawal scores at baseline than those with lower withdrawal scores. No relationship was found between treatment outcome and age, gender, race, education, employment, marital status, legal problems, baseline depression, or length/severity of drug use. Tobacco use was associated with worse opioid treatment outcomes. Severe baseline anxiety symptoms doubled treatment success. Medication type (buprenorphine-naloxone) was the most important predictor of positive outcome; however the paper also considers other clinical and policy implications of other results, including that inpatient setting predicted better outcomes and moderated medication outcomes. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ziedonis, Douglas M AU - Amass, Leslie AU - Steinberg, Marc AU - Woody, George AU - Krejciiii, Jonathan AU - Annon, Jeffrey J AU - Cohen, Allan J AU - Waite-O'Brien, Nancy AU - Stine, Susan M AU - McCarty, Dennis AU - Reid, Malcolm S AU - Brown, Lawrence S, Jr AU - Maslansky, Robert AU - Winhusen, Theresa AU - Babcock, Dean AU - Brigham, Greg AU - Muir, Joan AU - Orr, Deborah AU - Buchan, Betty J AU - Horton, Terry AU - Ling, Walter AD - National Institute on Drug Abuse Clinical Trials Network (CTN), University of Massachusetts Medical School, New England Node, Worcester, MA 01581, USA Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 28 EP - 36 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 99 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Buprenorphine Outcome predictors Heroin dependence Detoxification Opiate withdrawal Clinical trial KW - Withdrawal KW - Clonidine KW - Opioids KW - Analgesics KW - Treatment methods KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Predictors+of+outcome+for+short-term+medically+supervised+opioid+withdrawal+during+a+randomized%2C+multicenter+trial+of+buprenorphine-naloxone+and+clonidine+in+the+NIDA+clinical+trials+network+drug+and+alcohol+dependence&rft.au=Ziedonis%2C+Douglas+M%3BAmass%2C+Leslie%3BSteinberg%2C+Marc%3BWoody%2C+George%3BKrejciiii%2C+Jonathan%3BAnnon%2C+Jeffrey+J%3BCohen%2C+Allan+J%3BWaite-O%27Brien%2C+Nancy%3BStine%2C+Susan+M%3BMcCarty%2C+Dennis%3BReid%2C+Malcolm+S%3BBrown%2C+Lawrence+S%2C+Jr%3BMaslansky%2C+Robert%3BWinhusen%2C+Theresa%3BBabcock%2C+Dean%3BBrigham%2C+Greg%3BMuir%2C+Joan%3BOrr%2C+Deborah%3BBuchan%2C+Betty+J%3BHorton%2C+Terry%3BLing%2C+Walter&rft.aulast=Ziedonis&rft.aufirst=Douglas&rft.date=2009-01-01&rft.volume=99&rft.issue=1-3&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.06.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Analgesics; Clonidine; Opioids; Withdrawal; Treatment methods DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.06.016 ER - TY - JOUR T1 - Prevalence of Enuresis and Its Association With Attention-Deficit/Hyperactivity Disorder Among U.S. Children: Results From a Nationally Representative Study AN - 57276756; 200904887 AB - Objective: There are no published nationally representative prevalence estimates of enuresis among children in the United States using standardized diagnostic criteria. This study sets out to describe the prevalence, demographic correlates, comorbidities, and service patterns for enuresis in a representative sample of U.S. children. Method: The diagnosis of enuresis was derived from parent-reported data for "enuresis, nocturnal" collected using the computerized version of the Diagnostic Interview Schedule for Children (C-DISC 4.0) from a nationally representative sample of 8- to 11-year-old children (n = 1, 136) who participated in the 2001-2004 National Health and Nutrition Examination Surveys. Results: The overall 12-month prevalence of enuresis was 4.45%. The prevalence in boys (6.21%) was significantly greater than that in girls (2.51 %). Enuresis was more common at younger ages and among black youth. Attention-deficit/ hyperactivity disorder (ADHD) was strongly associated with enuresis (odds ratio 2.88; 95% confidence interval 1.26-6.57). Only 36% of the enuretic children had received health services for enuresis. Conclusions: Enuresis is a common condition among children in the United States. Few families seek treatment for enuresis despite the potential for adverse effects on emotional health. Child health care professionals should routinely screen for enuresis and its effects on the emotional health of the child and the family. Assessment of ADHD should routinely include evaluation for enuresis and vice versa. Research on the explanations for the association between enuresis and ADHD is indicated. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Shreeram, Srirangam AU - He, Jian-Ping AU - Kalaydjian, Amanda AU - Brothers, Shannon AU - Merikangas, Kathleen Ries AD - Genetic Epidemiology, Branch, National Institute of Mental Health, 35 Convent Drive, 1A-202, MSC 3720, Bethesda, MD 20892-3720 s.shreeram@dc.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 35 EP - 41 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 1 SN - 0890-8567, 0890-8567 KW - enuresis, prevalence, health care use, comorbidities, ADHD KW - Enuresis KW - Attention deficit hyperactivity disorder KW - Children KW - Side effects KW - Hyperactivity KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Prevalence+of+Enuresis+and+Its+Association+With+Attention-Deficit%2FHyperactivity+Disorder+Among+U.S.+Children%3A+Results+From+a+Nationally+Representative+Study&rft.au=Shreeram%2C+Srirangam%3BHe%2C+Jian-Ping%3BKalaydjian%2C+Amanda%3BBrothers%2C+Shannon%3BMerikangas%2C+Kathleen+Ries&rft.aulast=Shreeram&rft.aufirst=Srirangam&rft.date=2009-01-01&rft.volume=48&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e318190045c LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Enuresis; Children; Prevalence; Attention deficit hyperactivity disorder; Hyperactivity; Side effects DO - http://dx.doi.org/10.1097/CHI.0b013e318190045c ER - TY - JOUR T1 - Testing in semiparametric models with interaction, with applications to gene-environment interactions AN - 37057000; 3822521 AB - Motivated from the problem of testing for genetic effects on complex traits in the presence of gene-environment interaction, we develop score tests in general semiparametric regression problems that involves Tukey style 1 degree-of-freedom form of interaction between parametrically and non-parametrically modelled covariates. We find that the score test in this type model, as recently developed by Chatterjee and co-workers in the fully parametric setting, is biased and requires undersmoothing to be valid in the presence of non-parametric components. Moreover, in the presence of repeated outcomes, the asymptotic distribution of the score test depends on the estimation of functions which are defined as solutions of integral equations, making implementation difficult and computationally taxing. We develop profiled score statistics which are unbiased and asymptotically efficient and can be performed by using standard bandwidth selection methods. In addition, to overcome the difficulty of solving functional equations, we give easy interpretations of the target functions, which in turn allow us to develop estimation procedures that can be easily implemented by using standard computational methods. We present simulation studies to evaluate type I error and power of the method proposed compared with a naive test that does not consider interaction. Finally, we illustrate our methodology by analysing data from a case-control study of colorectal adenoma that was designed to investigate the association between colorectal adenoma and the candidate gene NAT2 in relation to smoking history. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Maity, A AU - Carroll, R J AU - Mammen, E AU - Chatterjee, N AD - Texas A&M University ; Universität Mannheim ; National Cancer Institute Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 75 EP - 96 VL - 71 IS - 1 SN - 1369-7412, 1369-7412 KW - Sociology KW - Semiparametric models KW - Evaluation KW - Measurement KW - Genes KW - Quantitative analysis KW - Regression analysis KW - Linear models KW - Estimation KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37057000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Testing+in+semiparametric+models+with+interaction%2C+with+applications+to+gene-environment+interactions&rft.au=Maity%2C+A%3BCarroll%2C+R+J%3BMammen%2C+E%3BChatterjee%2C+N&rft.aulast=Maity&rft.aufirst=A&rft.date=2009-01-01&rft.volume=71&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5455 1678; 4403 7854; 10739 12228 10919; 7419 8163; 7854; 10530 3279 971 3286; 4551; 12228 10919 ER - TY - JOUR T1 - BacA, an ABC Transporter Involved in Maintenance of Chronic Murine Infections with Mycobacterium tuberculosis AN - 21504597; 12493391 AB - BacA is an inner membrane protein associated with maintenance of chronic infections in several diverse host-pathogen interactions. To understand the function of the bacA gene in Mycobacterium tuberculosis (Rv1819c), we insertionally inactivated this gene and analyzed the resulting mutant for a variety of phenotypes. BacA deficiency in M. tuberculosis did not affect sensitivity to detergents, acidic pH, and zinc, indicating that there was no global compromise in membrane integrity, and a comprehensive evaluation of the major lipid constituents of the cell envelope failed to reveal any significant differences. Infection of mice with this mutant revealed no impact on establishment of infection but a profound effect on maintenance of extended chronic infection and ultimate outcome. As in alphaproteobacteria, deletion of BacA in M. tuberculosis led to increased bleomycin resistance, and heterologous expression of the M. tuberculosis BacA homolog in Escherichia coli conferred sensitivity to antimicrobial peptides. These results suggest a striking conservation of function for BacA-related proteins in transport of a critical molecule that determines the outcome of the host-pathogen interaction. JF - Journal of Bacteriology AU - Domenech, Pilar AU - Kobayashi, Hajime AU - LeVier, Kristin AU - Walker, Graham C AU - Barry III, Clifton E AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, 33 North Drive, Bethesda, Maryland 20892, cbarry@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 477 EP - 485 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 2 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Protein transport KW - ABC transporter KW - Detergents KW - Cell envelopes KW - Lipids KW - Membrane proteins KW - Bleomycin KW - Inner membranes KW - Host-pathogen interactions KW - Zinc KW - Chronic infection KW - Escherichia coli KW - Conservation KW - Tuberculosis KW - pH effects KW - Antimicrobial peptides KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21504597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=BacA%2C+an+ABC+Transporter+Involved+in+Maintenance+of+Chronic+Murine+Infections+with+Mycobacterium+tuberculosis&rft.au=Domenech%2C+Pilar%3BKobayashi%2C+Hajime%3BLeVier%2C+Kristin%3BWalker%2C+Graham+C%3BBarry+III%2C+Clifton+E&rft.aulast=Domenech&rft.aufirst=Pilar&rft.date=2009-01-01&rft.volume=191&rft.issue=2&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01132-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Protein transport; Detergents; ABC transporter; Lipids; Cell envelopes; Membrane proteins; Bleomycin; Host-pathogen interactions; Inner membranes; Chronic infection; Zinc; Conservation; Tuberculosis; Antimicrobial peptides; pH effects; Escherichia coli; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/JB.01132-08 ER - TY - JOUR T1 - The Crp-Activated Small Noncoding Regulatory RNA CyaR (RyeE) Links Nutritional Status to Group Behavior , AN - 21501153; 12493392 AB - Small noncoding regulatory RNAs (sRNAs) play a key role in regulating the expression of many genes in Escherichia coli and other bacteria. Many of the sRNAs identified in E. coli bind to mRNAs in an Hfq-dependent manner and stimulate or inhibit translation of the mRNAs. Several sRNAs are regulated by well-studied global regulators. Here, we report characterization of the CyaR (RyeE) sRNA, which was previously identified in a global search for sRNAs in E. coli. We demonstrated that CyaR is positively regulated by the global regulator Crp under conditions in which cyclic AMP levels are high. We showed by using microarray analysis and Northern blotting that several genes are negatively regulated by CyaR, including ompX, encoding a major outer membrane protein; luxS, encoding the autoinducer-2 synthase; nadE, encoding an essential NAD synthetase; and yqaE, encoding a predicted membrane protein with an unknown function. Using translational lacZ fusions to yqaE, ompX, nadE, and luxS, we demonstrated that the negative regulation of these genes by CyaR occurs at the posttranscriptional level and is direct. Different portions of a highly conserved 3' region of CyaR are predicted to pair with sequences near the ribosome binding site of each of these targets; mutations in this sequence affected regulation, and compensatory mutations in the target mRNA restored regulation, confirming that there is direct regulation by the sRNA. These results provide insight into the mechanisms by which Crp negatively regulates genes such as luxS and ompX and provide a link between catabolite repression, quorum sensing, and nitrogen assimilation in E. coli. JF - Journal of Bacteriology AU - Lay, Nicholas De AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, susang@helix.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 461 EP - 476 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 2 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Nutritional status KW - Translation KW - LuxS protein KW - quorum sensing KW - Cyclic AMP KW - Transcription KW - Ribosomes KW - Membrane proteins KW - Northern blotting KW - NAD KW - Gene regulation KW - Escherichia coli KW - Catabolite repression KW - Conserved sequence KW - Post-transcription KW - Major outer membrane protein KW - Mutation KW - N-octanoylhomoserine lactone KW - Nitrogen KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21501153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Crp-Activated+Small+Noncoding+Regulatory+RNA+CyaR+%28RyeE%29+Links+Nutritional+Status+to+Group+Behavior+%2C&rft.au=Lay%2C+Nicholas+De%3BGottesman%2C+Susan&rft.aulast=Lay&rft.aufirst=Nicholas&rft.date=2009-01-01&rft.volume=191&rft.issue=2&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01157-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Nutritional status; Translation; LuxS protein; quorum sensing; Cyclic AMP; Transcription; Ribosomes; Membrane proteins; Northern blotting; NAD; Gene regulation; Catabolite repression; Conserved sequence; Major outer membrane protein; Post-transcription; Mutation; N-octanoylhomoserine lactone; Nitrogen; Escherichia coli DO - http://dx.doi.org/10.1128/JB.01157-08 ER - TY - JOUR T1 - Trends in Prokaryotic Evolution Revealed by Comparison of Closely Related Bacterial and Archaeal Genomes AN - 21498589; 12493367 AB - In order to explore microevolutionary trends in bacteria and archaea, we constructed a data set of 41 alignable tight genome clusters (ATGCs). We show that the ratio of the medians of nonsynonymous to synonymous substitution rates (dN/dS) that is used as a measure of the purifying selection pressure on protein sequences is a stable characteristic of the ATGCs. In agreement with previous findings, parasitic bacteria, notwithstanding the sometimes dramatic genome shrinkage caused by gene loss, are typically subjected to relatively weak purifying selection, presumably owing to relatively small effective population sizes and frequent bottlenecks. However, no evidence of genome streamlining caused by strong selective pressure was found in any of the ATGCs. On the contrary, a significant positive correlation between the genome size, as well as gene size, and selective pressure was observed, although a variety of free-living prokaryotes with very close selective pressures span nearly the entire range of genome sizes. In addition, we examined the connections between the sequence evolution rate and other genomic features. Although gene order changes much faster than protein sequences during the evolution of prokaryotes, a strong positive correlation was observed between the QUOTATION_MARKrearrangement distanceQUOTATION_MARK and the amino acid distance, suggesting that at least some of the events leading to genome rearrangement are subjected to the same type of selective constraints as the evolution of amino acid sequences. JF - Journal of Bacteriology AU - Novichkov, Pavel S AU - Wolf, Yuri I AU - Dubchak, Inna AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, koonin@ncbi.nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 65 EP - 73 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 1 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Bacteria KW - Gene order KW - Data processing KW - Archaea KW - gene rearrangement KW - Atrophy KW - Prokaryotes KW - genomics KW - Evolution KW - A 01310:Products of Microorganisms KW - G 07770:Bacteria KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Trends+in+Prokaryotic+Evolution+Revealed+by+Comparison+of+Closely+Related+Bacterial+and+Archaeal+Genomes&rft.au=Novichkov%2C+Pavel+S%3BWolf%2C+Yuri+I%3BDubchak%2C+Inna%3BKoonin%2C+Eugene+V&rft.aulast=Novichkov&rft.aufirst=Pavel&rft.date=2009-01-01&rft.volume=191&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01237-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Gene order; gene rearrangement; Atrophy; genomics; Prokaryotes; Evolution; Bacteria; Archaea DO - http://dx.doi.org/10.1128/JB.01237-08 ER - TY - JOUR T1 - The Human Papillomavirus Type 8 E2 Tethering Protein Targets the Ribosomal DNA Loci of Host Mitotic Chromosomes AN - 21490227; 12493861 AB - For many papillomaviruses, the viral protein E2 tethers the viral genome to the host mitotic chromosomes to ensure persistent, long-term maintenance of the genome during cell division. Our previous studies of E2 proteins from different genera of papillomaviruses have shown that they bind to different regions of the host chromosomes during mitosis. For example, bovine papillomavirus type 1 (BPV-1) E2 binds to all chromosomes as small speckles in complex with the cellular protein Brd4. In contrast, the human papillomavirus type 8 (HPV-8) E2 protein binds as large speckles at the pericentromeric regions of chromosomes. Here we show that these speckles do not contain Brd4, and unlike that of BPV-1, the N-terminal Brd4-interacting domain of HPV-8 E2 is not required for chromosome binding. In contrast to BPV-1 E2, the HPV-8 E2 protein targets the short arms of acrocentric mitotic chromosomes. Furthermore, the E2 protein interacts with the repeated ribosomal DNA genes found in this location and colocalizes with UBF, the RNA polymerase I transcription factor. Therefore, HPV-8 E2 genome tethering occurs by a Brd4-independent mechanism through a novel interaction with specific regions of mitotic chromosomes. Thus, a wide range of viruses have adopted the strategy of linking their genomes to host chromosomes, but individual viruses use different chromosomal targets. Characterization of these targets will enable the development of antiviral therapies to eliminate the viral genomes from infected cells. JF - Journal of Virology AU - Poddar, Atasi AU - Reed, Shawna C AU - McPhillips, Maria G AU - Spindler, Jonathan E AU - McBride, Alison A AD - Laboratory of Viral Diseases, NIAID, NIH, Bethesda, Maryland, amcbride@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 640 EP - 650 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 2 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - Chromosomes KW - Cell division KW - DNA-directed RNA polymerase KW - Transcription factors KW - Mitosis KW - Bovine papillomavirus KW - DNA KW - E2 protein KW - Repeated DNA sequences KW - Human papillomavirus KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21490227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+Human+Papillomavirus+Type+8+E2+Tethering+Protein+Targets+the+Ribosomal+DNA+Loci+of+Host+Mitotic+Chromosomes&rft.au=Poddar%2C+Atasi%3BReed%2C+Shawna+C%3BMcPhillips%2C+Maria+G%3BSpindler%2C+Jonathan+E%3BMcBride%2C+Alison+A&rft.aulast=Poddar&rft.aufirst=Atasi&rft.date=2009-01-01&rft.volume=83&rft.issue=2&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01936-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Genomes; DNA-directed RNA polymerase; Cell division; Chromosomes; Mitosis; Transcription factors; DNA; E2 protein; Repeated DNA sequences; Bovine papillomavirus; Human papillomavirus DO - http://dx.doi.org/10.1128/JVI.01936-08 ER - TY - JOUR T1 - Differential Sensitivity of QUOTATION_MARKOldQUOTATION_MARK versus QUOTATION_MARKNewQUOTATION_MARK APOBEC3G to Human Immunodeficiency Virus Type 1 Vif AN - 21480010; 12493845 AB - HIV-1 Vif counteracts the antiviral activity of APOBEC3G by inhibiting its encapsidation into virions. Here, we compared the relative sensitivity to Vif of APOBEC3G in stable HeLa cells containing APOBEC3G (HeLa-A3G cells) versus that of newly synthesized APOBEC3G. We observed that newly synthesized APOBEC3G was more sensitive to degradation than preexisting APOBEC3G. Nevertheless, preexisting and transiently expressed APOBEC3G were packaged with similar efficiencies into vif-deficient human immunodeficiency virus type 1 (HIV-1) virions, and Vif inhibited the encapsidation of both forms of APOBEC3G into HIV particles equally well. Our results suggest that HIV-1 Vif preferentially induces degradation of newly synthesized APOBEC3G but indiscriminately inhibits encapsidation of QUOTATION_MARKoldQUOTATION_MARK and QUOTATION_MARKnewQUOTATION_MARK APOBEC3G. JF - Journal of Virology AU - Goila-Gaur, Ritu AU - Khan, Mohammad A AU - Miyagi, Eri AU - Strebel, Klaus AD - Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, Maryland 20892-0460, kstrebel@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 1156 EP - 1160 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 2 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Human immunodeficiency virus 1 KW - Encapsidation KW - Antiviral activity KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21480010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Cluster+of+Cases+of+Nosocomial+Legionnaires+Disease+Linked+to+a+Contaminated+Hospital+Decorative+Water+Fountain&rft.au=Palmore%2C+Tara+N%3BStock%2C+Frida%3BWhite%2C+Margaret%3BBordner%2C+MaryAnn%3BMichelin%2C+Angela%3BBennett%2C+John+E%3BMurray%2C+Patrick+R%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=8&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F598855 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Virions; Encapsidation; Antiviral activity; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.01734-08 ER - TY - JOUR T1 - Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods AN - 21445903; 11866173 AB - Although several genes (including a strong effect in the human leukocyte antigen (HLA) region) and some environmental factors have been implicated to cause susceptibility to rheumatoid arthritis (RA), the etiology of the disease is not completely understood. The ability to screen the entire genome for association to complex diseases has great potential for identifying gene effects. However, the efficiency of gene detection in this situation may be improved by methods specifically designed for high-dimensional data. The aim of this study was to compare how three different statistical approaches, multifactor dimensionality reduction (MDR), random forests (RF), and an omnibus approach, worked in identifying gene effects (including gene-gene interaction) associated with RA. We developed a test set of genes based on previous linkage and association findings and tested all three methods. In the presence of the HLA shared-epitope factor, other genes showed weaker effects. All three methods detected SNPs in PTPN22 and TRAF1-C5 as being important. But we did not detect any new genes in this study. We conclude that the three high-dimensional methods are useful as an initial screening for gene associations to identify promising genes for further modeling and additional replication studies. JF - BMC Proceedings AU - Liang, Xueying AU - Gao, Ying AU - Lam, Tram K AU - Li, Qizhai AU - Falk, Cathy AU - Yang, Xiaohong R AU - Goldstein, Alisa M AU - Goldin, Lynn R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA, liangx2@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S79 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 3 IS - Suppl 7 KW - Calcium & Calcified Tissue Abstracts; Immunology Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Histocompatibility antigen HLA KW - Genomes KW - Rheumatoid arthritis KW - Etiology KW - Statistics KW - Data processing KW - Replication KW - Single-nucleotide polymorphism KW - Forests KW - Environmental factors KW - Protein-tyrosine-phosphatase KW - G 07720:Immunogenetics KW - T 2055:Laboratory Methods KW - F 06930:Autoimmunity KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21445903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Successful+Mandatory+Influenza+Vaccination+Campaign+Using+an+Innovative+Electronic+Tracking+System&rft.au=Palmore%2C+Tara+N%3BVandersluis%2C+JPatrick%3BMorris%2C+Joan%3BMichelin%2C+Angela%3BRuprecht%3B%2C+Lisa+M%3BSchmitt%2C+James+M%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=12&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F648084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Genomes; Histocompatibility antigen HLA; Etiology; Rheumatoid arthritis; Data processing; Statistics; Single-nucleotide polymorphism; Replication; Forests; Environmental factors; Protein-tyrosine-phosphatase ER - TY - JOUR T1 - The potential for automated question answering in the context of genomic medicine: an assessment of existing resources and properties of answers AN - 21442870; 11861941 AB - Knowledge gained in studies of genetic disorders is reported in a growing body of biomedical literature containing reports of genetic variation in individuals that map to medical conditions and/or response to therapy. These scientific discoveries need to be translated into practical applications to optimize patient care. Translating research into practice can be facilitated by supplying clinicians with research evidence. We assessed the role of existing tools in extracting answers to translational research questions in the area of genomic medicine. We: evaluate the coverage of translational research terms in the Unified Medical Language Systems (UMLS) Metathesaurus; determine where answers are most often found in full-text articles; and determine common answer patterns. Findings suggest that we will be able to leverage the UMLS in development of natural language processing algorithms for automated extraction of answers to translational research questions from biomedical text in the area of genomic medicine. JF - BMC Bioinformatics AU - Overby, Casey Lynnette AU - Tarczy-Hornoch, Peter AU - Demner-Fushman, Dina AD - Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, BHHS, Bethesda, MD, USA, ddemner@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S8 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 IS - Suppl 9 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Algorithms KW - Genetic diversity KW - Language KW - Bioinformatics KW - genomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21442870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Intensive+care+unit-acquired+neuromyopathy+and+corticosteroids+in+survivors+of+persistent+ARDS&rft.au=Hough%2C+Catherine+L%3BSteinberg%2C+Kenneth+P%3BTaylor+Thompson%2C+B%3BRubenfeld%2C+Gordon+D%3BHudson%2C+Leonard+D&rft.aulast=Hough&rft.aufirst=Catherine&rft.date=2009-01-01&rft.volume=35&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-008-1304-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Translation; genomics; Language; Algorithms; Genetic diversity; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-10-S9-S8 ER - TY - JOUR T1 - A Successful Mandatory Influenza Vaccination Campaign Using an Innovative Electronic Tracking System AN - 21333289; 11839565 AB - Background. Although influenza vaccination of healthcare workers reduces influenza-like illness and overall mortality among patients, national rates of vaccination for healthcare providers are unacceptably low. We report the implementation of a new mandatory vaccination policy by means of a streamlined electronic enrollment and vaccination tracking system at the National Institutes of Health (NIH) Clinical Center. Objective. To evaluate the outcome of a new mandatory staff influenza vaccination program. Methods. A new hospital policy endorsed by all the component NIH institutes and the Clinical Center departments mandated that employees who have patient contact either be vaccinated annually against influenza or sign a declination specifying the reason(s) for refusal. Those who fail to comply would be required to appear before the Medical Executive Committee to explain their rationale. We collected in a database the names of all physician and nonphysician staff who had patient contact. When a staff member either was vaccinated or declined vaccination, a simple system of badge scanning and bar-coded data entry captured essential data. The database was continuously updated, and it provided a list of noncompliant employees with whom to follow up. Results. By February 12, 2009, all 2,754 identified patient-care employees either were vaccinated or formally declined vaccination. Among those, 2,424 (88%) were vaccinated either at the NIH or elsewhere, 36 (1.3%) reported medical contraindications, and 294 (10.7%) declined vaccination for other reasons. Among the 294 employees without medical contraindications who declined, the most frequent reason given for declination was concern about side effects. Conclusions. Implementation of a novel vaccination tracking process and a hospital policy requiring influenza vaccination or declination yielded dramatic improvement in healthcare worker vaccination rates and likely will result in increased patient safety in our hospital. JF - Infection Control and Hospital Epidemiology AU - Palmore, Tara N AU - Vandersluis, JPatrick AU - Morris, Joan AU - Michelin, Angela AU - Ruprecht AU - , Lisa M AU - Schmitt, James M AU - Henderson, David K AD - Clinical Center and the Occupational Medical Service, Division of Occupational Health and Safety, National Institutes of Health, Bethesda, Maryland, dkh@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1137 EP - 1142 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 12 SN - 0899-823X, 0899-823X KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21333289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Successful+Mandatory+Influenza+Vaccination+Campaign+Using+an+Innovative+Electronic+Tracking+System&rft.au=Palmore%2C+Tara+N%3BVandersluis%2C+JPatrick%3BMorris%2C+Joan%3BMichelin%2C+Angela%3BRuprecht%3B%2C+Lisa+M%3BSchmitt%2C+James+M%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=12&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F648084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1086/648084 ER - TY - JOUR T1 - Malaria Control, Elimination, and Eradication: The Role of the Evolving Biomedical Research Agenda AN - 21330767; 11839604 JF - Journal of Infectious Diseases AU - Hall, BFenton AU - Fauci, Anthony S AD - Parasitology and International Programs Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, lhall@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1639 EP - 1643 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 11 SN - 0022-1899, 0022-1899 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources KW - Human diseases KW - Infectious diseases KW - Malaria KW - Public health KW - K 03400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21330767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Malaria+Control%2C+Elimination%2C+and+Eradication%3A+The+Role+of+the+Evolving+Biomedical+Research+Agenda&rft.au=Hall%2C+BFenton%3BFauci%2C+Anthony+S&rft.aulast=Hall&rft.aufirst=BFenton&rft.date=2009-01-01&rft.volume=200&rft.issue=11&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F646611 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Human diseases; Infectious diseases; Malaria; Public health DO - http://dx.doi.org/10.1086/646611 ER - TY - JOUR T1 - Total Pesticide Exposure Calculation among Vegetable Farmers in Benguet, Philippines AN - 21282119; 11829330 AB - This was a cross-sectional study that investigated pesticide exposure and its risk factors targeting vegetable farmers selected through cluster sampling. The sampling size calculated with [[PQ_REPLACE:[math]]]P=.05 was 211 vegetable farmers and 37 farms. The mean usage of pesticide was 21.35 liters. Risk factors included damaged backpack sprayer (34.7%), spills on hands (31.8%), and spraying against the wind (58%). The top 3 pesticides used were pyrethroid (46.4%), organophosphates (24.2%), and carbamates (21.3%). Those who were exposed to fungicides and insecticides also had higher total pesticide exposure. Furthermore, a farmer who was a pesticide applicator, mixer, loader, and who had not been given instructions through training was at risk of having higher pesticide exposure. The most prevalent symptoms were headache (64.1%), muscle pain (61.1%), cough (45.5%), weakness (42.4%), eye pain (39.9%), chest pain (37.4%), and eye redness (33.8%). The data can be used for the formulation of an integrated program on safety and health in the vegetable industry. JF - Journal of Environmental and Public Health AU - Lu, Jinky Leilanie AD - National Institutes of Health University of the Philippines Manila Ermita, Manila 1100, jinky_lu@yahoo.com Y1 - 2009 PY - 2009 DA - 2009 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2009 KW - Environmental Engineering Abstracts; Environment Abstracts KW - Philippines KW - Eye KW - Training KW - Organophosphates KW - Sprays KW - Muscles KW - pain KW - farms KW - Fungicides KW - Pesticides KW - EE 10:General Environmental Engineering KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21282119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+and+Public+Health&rft.atitle=Total+Pesticide+Exposure+Calculation+among+Vegetable+Farmers+in+Benguet%2C+Philippines&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2009-01-01&rft.volume=2009&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+and+Public+Health&rft.issn=1687-9813&rft_id=info:doi/10.1155%2F2009%2F412054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Philippines; Pesticides; pain; Eye; Sprays; Organophosphates; Muscles; Fungicides; farms; Training DO - http://dx.doi.org/10.1155/2009/412054 ER - TY - JOUR T1 - Chlamydia trachomatis Polymorphic Membrane Protein D Is an Oligomeric Autotransporter with a Higher-Order Structure AN - 21280180; 12511026 AB - Chlamydia trachomatis is a globally important obligate intracellular bacterial pathogen that is a leading cause of sexually transmitted disease and blinding trachoma. Effective control of these diseases will likely require a preventative vaccine. C. trachomatis polymorphic membrane protein D (PmpD) is an attractive vaccine candidate as it is conserved among C. trachomatis strains and is a target of broadly cross-reactive neutralizing antibodies. We show here that immunoaffinity-purified native PmpD exists as an oligomer with a distinct 23-nm flower-like structure. Two-dimensional blue native-sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses showed that the oligomers were composed of full-length PmpD (p155) and two proteolytically processed fragments, the p73 passenger domain (PD) and the p82 translocator domain. We also show that PmpD undergoes an infection-dependent proteolytic processing step late in the growth cycle that yields a soluble extended PD (p111) that was processed into a p73 PD and a novel p30 fragment. Interestingly, soluble PmpD peptides possess putative eukaryote-interacting functional motifs, implying potential secondary functions within or distal to infected cells. Collectively, our findings show that PmpD exists as two distinct forms, a surface-associated oligomer exhibiting a higher-order flower-like structure and a soluble form restricted to infected cells. We hypothesize that PmpD is a multifunctional virulence factor important in chlamydial pathogenesis and could represent novel vaccine or drug targets for the control of human chlamydial infections. JF - Infection and Immunity AU - Swanson, Kena A AU - Taylor, Lacey D AU - Frank, Shaun D AU - Sturdevant, Gail L AU - Fischer, Elizabeth R AU - Carlson, John H AU - Whitmire, William M AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, hcaldwell@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 508 EP - 516 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Proteolysis KW - virulence factors KW - Sexually-transmitted diseases KW - Disease control KW - Chlamydia trachomatis KW - Membrane proteins KW - Pathogens KW - Immunity KW - Infection KW - Gel electrophoresis KW - Trachoma KW - Disease transmission KW - Virulence KW - Antibodies KW - Growth KW - Proteins KW - Vaccines KW - Drugs KW - A 01490:Miscellaneous KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21280180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Chlamydia+trachomatis+Polymorphic+Membrane+Protein+D+Is+an+Oligomeric+Autotransporter+with+a+Higher-Order+Structure&rft.au=Swanson%2C+Kena+A%3BTaylor%2C+Lacey+D%3BFrank%2C+Shaun+D%3BSturdevant%2C+Gail+L%3BFischer%2C+Elizabeth+R%3BCarlson%2C+John+H%3BWhitmire%2C+William+M%3BCaldwell%2C+Harlan+D&rft.aulast=Swanson&rft.aufirst=Kena&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01173-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Virulence; Growth; Antibodies; Disease control; Proteins; Immunity; Pathogens; Vaccines; Disease transmission; Proteolysis; Sexually-transmitted diseases; virulence factors; Membrane proteins; Infection; Drugs; Gel electrophoresis; Trachoma; Chlamydia trachomatis DO - http://dx.doi.org/10.1128/IAI.01173-08 ER - TY - JOUR T1 - Perspective on Malaria Eradication: Is Eradication Possible without Modifying the Mosquito? AN - 21274813; 11839605 JF - Journal of Infectious Diseases AU - Miller, Louis H AU - Pierce, Susan K AD - The Malaria Vaccine Development Branch and Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, lomiller@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1644 EP - 1645 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 11 SN - 0022-1899, 0022-1899 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; Entomology Abstracts KW - Human diseases KW - Infectious diseases KW - Culicidae KW - Malaria KW - Aquatic insects KW - Public health KW - K 03400:Human Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21274813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Perspective+on+Malaria+Eradication%3A+Is+Eradication+Possible+without+Modifying+the+Mosquito%3F&rft.au=Miller%2C+Louis+H%3BPierce%2C+Susan+K&rft.aulast=Miller&rft.aufirst=Louis&rft.date=2009-01-01&rft.volume=200&rft.issue=11&rft.spage=1644&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F646612 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Human diseases; Infectious diseases; Malaria; Aquatic insects; Public health; Culicidae DO - http://dx.doi.org/10.1086/646612 ER - TY - JOUR T1 - The Effect of Exercise Intensity on Serum Leptin and C-Reactive Protein Levels AN - 21233223; 11774511 AB - Recently, serum leptin and C-reactive protein (CRP) levels have been regarded as independent predictive factors for heart disease. Although exercise intensity and duration may influence leptin and CRP concentrations, few studies have investigated this. In addition, leptin and CRP exhibit trends (downward and upward, respectively) after an acute bout of aerobic exercise. There seems to be a negative association between them, which may differ from the baseline; however, no study has tested this assumption. Therefore, we investigated the effect of exercise intensity on serum leptin and CRP levels and compared changes and differences in both relationships with different exercise intensities. In addition to the VO sub(2max) test, 13 male subjects (21.5 c 1.8 years old, 18.5 c 4.0%body fat, 55.0 c 3.8 mL ; kg super(-1) ; min super(-1) VO sub(2max)) exercised at two other exercise intensities (85% VO sub(2max) and 65% VO sub(2max)) in a randomized order. Blood samples were collected before and immediately after each trial to analyze pre- and post-exercise leptin and CRP concentrations in the three trials. While there were no significant differences in post-exercise leptin and CRP levels among the different exercise intensities, there were significant differences between leptin and CRP concentrations before and after exercise bouts corresponding to 65% and 85% VO sub(2max). In addition, post-exercise leptin and CRP levels were not associated. The results of this study suggest that leptin and CRP do not differ among different exercise intensities. Alteration in CRP and body fat percentage did not contribute to the change in leptin in these acute exercise models. JF - Journal of Exercise Science and Fitness AU - Tsao, T-H AU - Hsu, C-H AU - Yang, C-B AU - Liou, T-L AD - Department of Recreation Sports and Health Promotion, National Pingtung University of Science and Technology, 1 Hseuh-Fu Road, Nei-Pu Township, Pingtung 912, TAIWAN, thtsao@mail.npust.edu.tw Y1 - 2009 PY - 2009 DA - 2009 SP - 98 EP - 103 VL - 7 IS - 2 SN - 1728-869X, 1728-869X KW - Physical Education Index KW - Fitness KW - Blood KW - Aerobics KW - Exercise (intensity) KW - Analysis KW - Proteins KW - Hormones KW - Maximum oxygen consumption KW - Heart diseases KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21233223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exercise+Science+and+Fitness&rft.atitle=The+Effect+of+Exercise+Intensity+on+Serum+Leptin+and+C-Reactive+Protein+Levels&rft.au=Tsao%2C+T-H%3BHsu%2C+C-H%3BYang%2C+C-B%3BLiou%2C+T-L&rft.aulast=Tsao&rft.aufirst=T-H&rft.date=2009-01-01&rft.volume=7&rft.issue=2&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exercise+Science+and+Fitness&rft.issn=1728869X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Fitness; Blood; Aerobics; Exercise (intensity); Analysis; Proteins; Maximum oxygen consumption; Hormones; Heart diseases ER - TY - JOUR T1 - Human Type 1 and 17 Responses in Latent Tuberculosis Are Modulated by Coincident Filarial Infection through Cytotoxic T Lymphocyte Antigen-4 and Programmed Death-1 AN - 21222190; 11189284 AB - Mycobacterium tuberculosis and filarial coinfection is highly prevalent, and the presence of a tissue-invasive helminth may modulate the predominant type 1 T helper (Th1; interferon [IFN]--mediated) response needed to control M. tuberculosis infection. By analyzing the cellular responses to mycobacterial antigens in patients who had latent tuberculosis with or without filarial infection, we were able to demonstrate that filarial infection coincident with M. tuberculosis infection significantly diminishes M. tuberculosis-specific Th1 (interleukin [IL]-12 and IFN-) and type 17 T helper (Th17; IL-23 and IL-17) responses related to increased expression of cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1. Blockade of CTLA-4 restored production of both IFN- and IL-17, whereas PD-1 blockade restored IFN- production only. Thus, coincident filarial infection exerted a profound inhibitory effect on protective mycobacteria-specific Th1 and Th17 responses in latent tuberculosis, suggesting a mechanism by which concomitant filarial (and other systemic helminth) infections predispose to the development of active tuberculosis in humans. JF - Journal of Infectious Diseases AU - Babu, Subash AU - Bhat, Sajid Q AU - Kumar, NPavan AU - Jayantasri, S AU - Rukmani, S AU - Kumaran, Paul AU - Gopi, P G AU - Kolappan, C AU - Kumaraswami, V AU - Nutman, Thomas B AD - National Institutes of Health-International Center for Excellence in Research and Tuberculosis Research Center, Chennai, India, sbabu@mail.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 288 EP - 298 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 2 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Interferon KW - PD-1 protein KW - Cytotoxicity KW - Interleukin 23 KW - CTLA-4 protein KW - Helper cells KW - Interleukin 17 KW - Lymphocytes T KW - Tuberculosis KW - Infection KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21222190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Human+Type+1+and+17+Responses+in+Latent+Tuberculosis+Are+Modulated+by+Coincident+Filarial+Infection+through+Cytotoxic+T+Lymphocyte+Antigen-4+and+Programmed+Death-1&rft.au=Babu%2C+Subash%3BBhat%2C+Sajid+Q%3BKumar%2C+NPavan%3BJayantasri%2C+S%3BRukmani%2C+S%3BKumaran%2C+Paul%3BGopi%2C+P+G%3BKolappan%2C+C%3BKumaraswami%2C+V%3BNutman%2C+Thomas+B&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2009-01-01&rft.volume=200&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - PD-1 protein; Interferon; Cytotoxicity; Interleukin 23; CTLA-4 protein; Interleukin 17; Helper cells; Lymphocytes T; Tuberculosis; Infection; Mycobacterium tuberculosis ER - TY - JOUR T1 - HIV-1 RNA Dimerization: It Takes Two to Tango AN - 21213297; 11149485 AB - Each viral particle of HIV-1, the infectious agent of AIDS, contains two copies of the full-length viral genomic RNA. Encapsldating two copies of genomic RNA is one of the characteristics of the retrovirus family. The two RNA molecules are both positive-sense and often identical; furthermore, each RNA encodes the full complement of genetic information required for viral replication. The two strands of RNA are intricately entwined within the core of the mature infectious virus as a ribonuclear complex with the viral proteins, including nucleocapsid. Multiple steps in the biogenesis of the genomic full-length RNA are involved in achieving this location and dimeric state. The viral sequences and proteins involved in the process of RNA dimerization, both for the initial interstrand contact and subsequent steps that result in the condensed, stable conformation of the genomic RNA, are outlined in this review. In addition, the impact of the dimeric state of HIV-1 viral RNA is discussed with respect to its importance in efficient viral replication and, consequently, the potential development of antiviral strategies designed to disrupt the formation of dimeric RNA. JF - AIDS Reviews AU - Moore, MD AU - Hu, W-S AD - HIV Drug Resistance Program, National Cancer Institute, Frederick, MD, USA, whu@ncifcrf.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 91 EP - 102 VL - 11 IS - 2 SN - 1139-6121, 1139-6121 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Retrovirus KW - RNA KW - Replication KW - Human immunodeficiency virus 1 KW - Nucleocapsids KW - genomics KW - Conformation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21213297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Reviews&rft.atitle=HIV-1+RNA+Dimerization%3A+It+Takes+Two+to+Tango&rft.au=Moore%2C+MD%3BHu%2C+W-S&rft.aulast=Moore&rft.aufirst=MD&rft.date=2009-01-01&rft.volume=11&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=AIDS+Reviews&rft.issn=11396121&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Retrovirus; RNA; Replication; Nucleocapsids; genomics; Conformation; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Safety and Immunogenicity of Multiple and Higher Doses of an Inactivated Influenza A/H5N1 Vaccine AN - 21210075; 11189460 AB - Background. H5N1 avian influenza represents an episodic zoonotic disease with the potential to cause a pandemic, and antiviral resistance is of considerable concern. We sought to generate high-titer H5N1 antibodies in healthy volunteers for the purpose of developing hyperimmune intravenous immunoglobulin. Methods. We conducted a dose-escalating, unblinded clinical trial involving 75 subjects aged 18-59 years. Three cohorts of twenty-five subjects were enrolled sequentially and received 90, 120, or 180 [mu]g of H5N1 A/Vietnam/1203/04 vaccine in 4 doses administered [image]28 days apart. Results. No statistically significant dose-related increases in the geometric mean titers (GMTs) of serum hemagglutination inhibition antibody were observed when the 90-[mu]g, 120-[mu]g, and 180-[mu]g cohorts were compared. When the cohorts were analyzed together to determine the effect of additional vaccinations, the GMTs of hemagglutination inhibition antibody after the first, second, third, and fourth vaccinations were 1:15.7, 1:22.2, 1:36.0, and 1:32.0, respectively (first vaccination vs. baseline, [image] ; second vs. first vaccination, [image] ; and third vs. second vaccination, [image]). The microneutralization GMTs after the first, second, third, and fourth vaccinations were 1:17.5, 1:33.1, 1:55.7, and 1:68.4, respectively ([image] for all comparisons). Conclusion. The results of our study suggest that a third and fourth dose of the H5N1 A/Vietnam/1203/04 vaccine may result in higher hemagglutination inhibition and microneutralization GMTs, compared with the GMTs resulting from fewer doses. There was no benefit to increasing the dose of the vaccine. Trial registration. Clinical Trials.gov identifier: JF - Journal of Infectious Diseases AU - Beigel, John H AU - Voell, Jocelyn AU - Huang, Chiung-Yu AU - Burbelo, Peter D AU - Lane, HClifford AD - National Institute of Allergy and Infectious Diseases and National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, jbeigel@niaid.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 501 EP - 508 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 4 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - vaccines KW - Intravenous administration KW - Hemagglutination inhibition KW - Influenza A KW - immunogenicity KW - Statistical analysis KW - clinical trials KW - Vaccination KW - Clinical trials KW - Vietnam KW - influenza KW - Fowl plague KW - pandemics KW - Immunogenicity KW - Vaccines KW - Immunoglobulins KW - A 01340:Antibiotics & Antimicrobials KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21210075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Safety+and+Immunogenicity+of+Multiple+and+Higher+Doses+of+an+Inactivated+Influenza+A%2FH5N1+Vaccine&rft.au=Beigel%2C+John+H%3BVoell%2C+Jocelyn%3BHuang%2C+Chiung-Yu%3BBurbelo%2C+Peter+D%3BLane%2C+HClifford&rft.aulast=Beigel&rft.aufirst=John&rft.date=2009-01-01&rft.volume=200&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Fowl plague; pandemics; Intravenous administration; Immunogenicity; Influenza A; Hemagglutination inhibition; Statistical analysis; Vaccines; Clinical trials; Vaccination; Immunoglobulins; vaccines; immunogenicity; clinical trials; influenza; Vietnam ER - TY - JOUR T1 - A Cluster of Cases of Nosocomial Legionnaires Disease Linked to a Contaminated Hospital Decorative Water Fountain AN - 21209209; 11189151 AB - Background. Nosocomial outbreaks of Legionnaires disease have been linked to contaminated water in hospitals. Immunocompromised patients are particularly vulnerable and, when infected, have a high mortality rate. We report the investigation of a cluster of cases of nosocomial pneumonia attributable to Legionella pneumophila serogroup 1 that occurred among patients on our stem cell transplantation unit. Methods. We conducted a record review to identify common points of potential exposure, followed by environmental and water sampling for Legionella species from those sources. We used an air sampler to in an attempt to detect aerosolized Legionella and pulsed-field gel electrophoresis to compare clinical and environmental isolates. Results. The most likely sources identified were the water supply in the patients' rooms and a decorative fountain in the radiation oncology suite. Samples from the patients' rooms did not grow Legionella species. Cultures of the fountain, which had been restarted 4 months earlier after being shut off for 5 months, yielded L. pneumophila serogroup 1. The isolates from both patients and the fountain were identical by pulsed-field gel electrophoresis. Both patients developed pneumonia within 10 days of completing radiation therapy, and each reported having observed the fountain at close range. Both patients' infections were identified early and treated promptly, and both recovered. Conclusions. This cluster was caused by contamination of a decorative fountain despite its being equipped with a filter and ozone generator. Fountains are a potential source of nosocomial Legionnaires disease despite standard maintenance and sanitizing measures. In our opinion, fountains present unacceptable risk in hospitals serving immunocompromised patients. JF - Infection Control and Hospital Epidemiology AU - Palmore, Tara N AU - Stock, Frida AU - White, Margaret AU - Bordner, MaryAnn AU - Michelin, Angela AU - Bennett, John E AU - Murray, Patrick R AU - Henderson, David K AD - Warren Grant Magnusen Clinical Center and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., tpalmore@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 764 EP - 768 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 8 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Health & Safety Science Abstracts KW - Contamination KW - Cell culture KW - Oncology KW - Water supplies KW - Radiation KW - Air sampling KW - Vulnerability KW - Ozone KW - outbreaks KW - Immunocompromised hosts KW - vulnerability KW - Pneumonia KW - Hospitals KW - Legionella pneumophila KW - Water sampling KW - Infection KW - infection KW - water pollution KW - Radiation therapy KW - Mortality KW - Electrophoresis KW - stem cell transplantation KW - Samplers KW - Maintenance KW - Legionnaire's disease KW - Water pollution KW - Filters KW - Reviews KW - Pulsed-field gel electrophoresis KW - Outbreaks KW - J 02420:Plant Diseases KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21209209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Cluster+of+Cases+of+Nosocomial+Legionnaires+Disease+Linked+to+a+Contaminated+Hospital+Decorative+Water+Fountain&rft.au=Palmore%2C+Tara+N%3BStock%2C+Frida%3BWhite%2C+Margaret%3BBordner%2C+MaryAnn%3BMichelin%2C+Angela%3BBennett%2C+John+E%3BMurray%2C+Patrick+R%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=8&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F598855 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Water sampling; Contamination; stem cell transplantation; Oncology; Cell culture; Infection; Samplers; Water supplies; Filters; Radiation; Immunocompromised hosts; Pulsed-field gel electrophoresis; Pneumonia; Ozone; Hospitals; Radiation therapy; Electrophoresis; outbreaks; Water pollution; Legionnaire's disease; Maintenance; Reviews; Air sampling; infection; vulnerability; Vulnerability; Outbreaks; water pollution; Legionella pneumophila DO - http://dx.doi.org/10.1086/598855 ER - TY - JOUR T1 - A Point Mutation in the agr Locus rather than Expression of the Panton-Valentine Leukocidin Caused Previously Reported Phenotypes in Staphylococcus aureus Pneumonia and Gene Regulation AN - 21206065; 11189485 AB - sThe role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S. aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by earlier investigators. In agreement with other studies that failed to detect similar effects of PVL using community-associated methicillin-resistant S. aureus strains, we found no significant effect of PVL on gene expression or pathogenesis after we repaired the mutation. These findings provide further evidence that PVL does not have a major impact on S. aureus pathogenesis. Moreover, our results demonstrate that a single nucleotide polymorphism in an intergenic region can dramatically affect bacterial physiology and virulence. Finally, our work emphasizes the need to frequently evaluate the integrity of the S. aureus agr locus. JF - Journal of Infectious Diseases AU - Villaruz, Amer E AU - Wardenburg, Juliane Bubeck AU - Khan, Burhan A AU - Whitney, Adeline R AU - Sturdevant, Daniel E AU - Gardner, Donald J AU - DeLeo, Frank R AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, motto@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 724 EP - 734 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 5 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Promoters KW - leukocidin KW - Single-nucleotide polymorphism KW - Gene regulation KW - Drug resistance KW - Point mutation KW - Staphylococcus aureus KW - Pneumonia KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - N 14845:Miscellaneous KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21206065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=A+Point+Mutation+in+the+agr+Locus+rather+than+Expression+of+the+Panton-Valentine+Leukocidin+Caused+Previously+Reported+Phenotypes+in+Staphylococcus+aureus+Pneumonia+and+Gene+Regulation&rft.au=Villaruz%2C+Amer+E%3BWardenburg%2C+Juliane+Bubeck%3BKhan%2C+Burhan+A%3BWhitney%2C+Adeline+R%3BSturdevant%2C+Daniel+E%3BGardner%2C+Donald+J%3BDeLeo%2C+Frank+R%3BOtto%2C+Michael&rft.aulast=Villaruz&rft.aufirst=Amer&rft.date=2009-01-01&rft.volume=200&rft.issue=5&rft.spage=724&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F604728 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Virulence; Promoters; leukocidin; Single-nucleotide polymorphism; Drug resistance; Gene regulation; Point mutation; Pneumonia; Staphylococcus aureus DO - http://dx.doi.org/10.1086/604728 ER - TY - JOUR T1 - Interleukin-2 cycling causes transient increases in high-sensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels AN - 21077976; 11087108 AB - Objective: To determine the effects of interleukin (IL)-2 treatment on inflammatory and thrombotic biomarkers in chronically HIV-infected adults receiving antiretroviral therapy. Methods: Cryopreserved plasma was evaluated retrospectively for C-reactive protein (CRP) and D-dimer at baseline, end of an IL-2 cycle, and long-term follow up from two randomized, controlled trials: 57 IL-2-naive adults receiving either three to six cycles of IL-2 as well as antiretroviral therapy (nucleoside analogues) or antiretroviral therapy alone for 12 months, and 40 IL-2-experienced adults on highly active antiretroviral therapy who either interrupted or continued therapy for 6 months after a baseline IL-2 cycle. High-sensitivity CRP (hsCRP) was measured by immunonephelometry (detection limit 0.175 mg/l) and D-dimer by latex agglutination (detection limit0.20 mg/l). Median within-group differences and pre and post-IL-2 changes between groups were assessed via nonparametric Wilcoxon signed-rank and Mann-Whitney U-tests. Spearman's rank test was used to assess correlations between changes in hsCRP, D-dimer, and HIV-RNA viral load. Results: Significant increases in hsCRP (study 1: 138.6 mg/l; study 2: 58.9 mg/l) and D-dimer (study 1:3.1 mg/l; study 2: 0.4 mg/l, all P < 0.0001) occurred by the end of the initial IL-2 cycle, returning to baseline by the end of study. No correlations were seen between changes in hsCRP or D-dimer and HIV-RNA, CD4 T-cell count, or proliferation (Ki67 expression). No thrombotic or cardiovascular serious adverse events occurred during these study periods. Conclusion: IL-2 dosing caused transient increases in plasma hsCRP and D-dimer levels, regardless of HIV-RNA viral load, suggesting the possibility of increased risk for thrombotic events. JF - AIDS AU - Porter, BO AU - Shen, J AU - Kovacs, JA AU - Davey, R T AU - Rehm, C AU - Lozier, J AU - Csako, G AU - Nghiem, K AU - Costello, R AU - Lane, H C AU - Sereti, I AD - National Institutes of Health, Building 10, Clinical Center, Room 11B07A, 10 Center Drive, Bethesda, MD 20892, USA, isereti@niaid.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 2015 EP - 2019 VL - 23 IS - 15 SN - 0269-9370, 0269-9370 KW - HIV KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Bioindicators KW - Acquired immune deficiency syndrome KW - Interleukin 2 KW - Latex agglutination KW - clinical trials KW - Antiretroviral agents KW - Clinical trials KW - biomarkers KW - Cryopreservation KW - Inflammation KW - nucleoside analogs KW - CD4 antigen KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - antiretroviral agents KW - Lymphocytes T KW - Proteins KW - Side effects KW - C-reactive protein KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21077976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Interleukin-2+cycling+causes+transient+increases+in+high-sensitivity+C-reactive+protein+and+D-dimer+that+are+not+associated+with+plasma+HIV-RNA+levels&rft.au=Porter%2C+BO%3BShen%2C+J%3BKovacs%2C+JA%3BDavey%2C+R+T%3BRehm%2C+C%3BLozier%2C+J%3BCsako%2C+G%3BNghiem%2C+K%3BCostello%2C+R%3BLane%2C+H+C%3BSereti%2C+I&rft.aulast=Porter&rft.aufirst=BO&rft.date=2009-01-01&rft.volume=23&rft.issue=15&rft.spage=2015&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988004-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - nucleoside analogs; CD4 antigen; Interleukin 2; highly active antiretroviral therapy; Latex agglutination; Lymphocytes T; Cryopreservation; biomarkers; Inflammation; C-reactive protein; Bioindicators; Acquired immune deficiency syndrome; antiretroviral agents; Proteins; clinical trials; Clinical trials; Antiretroviral agents; Side effects; Human immunodeficiency virus DO - http://dx.doi.org/10.1097/QAD.0b013e32832d72c6 ER - TY - JOUR T1 - Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy? AN - 20797375; 10885500 AB - Introduction Experimental streptococcal cell wall (SCW)-induced arthritis is characterized by two successive phases of the disease. The acute phase occurs early and is associated with an inflammatory process and neutrophil infiltration into the synovium. The second chronic phase is related to effector T-cell activation and the dysregulation of macrophage function. Creation of an immunomodulatory environment has been attributed to apoptotic cells themselves, apoptotic cell uptake by phagocytes as well as a less sensibility of phagocytes capturing apoptotic bodies to activation. Therefore we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats. Methods Rat apoptotic thymocytes were injected intraperitoneally (2 x 10 super(8)) in addition to an arthritogenic dose of systemic SCW in LEW female rats. Control rats received SCW immunization and PBS. Rats were then followed for arthritis occurrence and circulating cytokine detection. At sacrifice, regulatory T cells (Tregs) and macrophages were analyzed. Results Apoptotic cell injection profoundly suppressed joint swelling and destruction typically observed during the acute and chronic phases of SCW-induced arthritis. Synovial inflammatory cell infiltration and bone destruction were also markedly suppressed. Ex vivo experiments revealed reduced levels of TNF in cultures of macrophages from rats challenged with SCW in the presence of apoptotic thymocytes as well as reduced macrophage response to lipopolysaccharide. Moreover, apoptotic cell injection induced higher Foxp3+ Tregs in the lymphoid organs, especially in the draining lymph nodes. Conclusions Our data indicate that apoptotic cells modulate macrophage function and result in Treg generation/increase. This may be involved in inhibition of inflammation and amelioration of arthritis. This highlights and confirms previous studies showing that in vivo generation of Tregs using apoptotic cell injection may be a useful tool to prevent and treat inflammatory autoimmune responses. JF - Arthritis Research & Therapy AU - Perruche, S AU - Saas, P AU - Chen, W AD - Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1 VL - 11 IS - 4 SN - 1478-6354, 1478-6354 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Immunoregulation KW - Apoptosis KW - Synovium KW - Tumor necrosis factor KW - Joint diseases KW - Cell culture KW - Immunomodulation KW - Cell activation KW - Phagocytes KW - Foxp3 protein KW - Arthritis KW - Lymphocytes T KW - Cytokines KW - Lipopolysaccharides KW - Streptococcus KW - Data processing KW - Leukocytes (neutrophilic) KW - Immunization KW - Lymph nodes KW - Inflammation KW - Bone loss KW - Thymocytes KW - Cell walls KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20797375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Apoptotic+cell-mediated+suppression+of+streptococcal+cell+wall-induced+arthritis+is+associated+with+alteration+of+macrophage+function+and+local+regulatory+T-cell+increase%3A+a+potential+cell-based+therapy%3F&rft.au=Perruche%2C+S%3BSaas%2C+P%3BChen%2C+W&rft.aulast=Perruche&rft.aufirst=S&rft.date=2009-01-01&rft.volume=11&rft.issue=4&rft.spage=R104&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2750 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Macrophages; Immunoregulation; Data processing; Apoptosis; Synovium; Tumor necrosis factor; Leukocytes (neutrophilic); Joint diseases; Cell culture; Immunomodulation; Lymph nodes; Immunization; Inflammation; Cell activation; Foxp3 protein; Phagocytes; Arthritis; Bone loss; Lymphocytes T; Lipopolysaccharides; Cytokines; Thymocytes; Cell walls; Streptococcus DO - http://dx.doi.org/10.1186/ar2750 ER - TY - JOUR T1 - The SaeR/S Gene Regulatory System Is Essential for Innate Immune Evasion by Staphylococcus aureus AN - 20756349; 10190602 AB - Methicillin-resistant Staphylococcus aureus is problematic both in hospitals and in the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S 2-component gene regulatory system and studied its role in mouse models of pathogenesis and during human neutrophil interaction. In this study, we demonstrate that saeR/S plays a distinct role in S. aureus pathogenesis and is vital for virulence of MW2 in a mouse model of sepsis. Moreover, deletion of saeR/S significantly impaired survival of MW2 in human blood and after neutrophil phagocytosis. Microarray analysis revealed that SaeR/S of MW2 influences expression of a wide variety of genes with diverse biological functions. These data provide new insight into how virulence is regulated in S. aureus and associates a specific staphylococcal gene-regulatory system with invasive staphylococcal disease. JF - Journal of Infectious Diseases AU - Voyich, Jovanka M AU - Vuong, Cuong AU - DeWald, Mark AU - Nygaard, Tyler K AU - Kocianova, Stanislava AU - Griffith, Shannon AU - Jones, Jennifer AU - Iverson, Courtney AU - Sturdevant, Daniel E AU - Braughton, Kevin R AU - Whitney, Adeline R AU - Otto, Michael AU - DeLeo, Frank R AD - Department of Veterinary Molecular Biology, Montana State University, Bozeman, and Laboratory of Human Bacterial Pathogenesis and Genomics Unit, Research Technologies Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, jovanka@montana.edu Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1698 EP - 1706 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 11 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Immunology Abstracts KW - Cell survival KW - Deletion mutant KW - Data processing KW - Drug resistance KW - Leukocytes (neutrophilic) KW - Animal models KW - Virulence KW - Blood KW - Sepsis KW - Gene regulation KW - S gene KW - Staphylococcus aureus KW - Phagocytosis KW - Hospitals KW - J 02410:Animal Diseases KW - G 07870:Mammals KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20756349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=The+SaeR%2FS+Gene+Regulatory+System+Is+Essential+for+Innate+Immune+Evasion+by+Staphylococcus+aureus&rft.au=Voyich%2C+Jovanka+M%3BVuong%2C+Cuong%3BDeWald%2C+Mark%3BNygaard%2C+Tyler+K%3BKocianova%2C+Stanislava%3BGriffith%2C+Shannon%3BJones%2C+Jennifer%3BIverson%2C+Courtney%3BSturdevant%2C+Daniel+E%3BBraughton%2C+Kevin+R%3BWhitney%2C+Adeline+R%3BOtto%2C+Michael%3BDeLeo%2C+Frank+R&rft.aulast=Voyich&rft.aufirst=Jovanka&rft.date=2009-01-01&rft.volume=199&rft.issue=11&rft.spage=1698&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F598967 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Cell survival; Data processing; Deletion mutant; Drug resistance; Animal models; Leukocytes (neutrophilic); Virulence; Blood; Sepsis; Gene regulation; S gene; Phagocytosis; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1086/598967 ER - TY - JOUR T1 - The MUC1 oncoprotein as a functional target: Immunotoxin binding to alpha / beta junction mediates cell killing AN - 20628111; 9356006 AB - MUC1, a heavily glycosylated mucin, has generated considerable interest as a target for tumor killing because of its overexpression in malignancies. Full-length MUC1 (MUC1/TM) is proteolytically cleaved after synthesis generating and subunits, which specifically bind in a noncovalent interaction. Although the chain remains on the cell surface, the chain binds in an on-and-off interaction. Most anti-MUC1 antibodies (Abs) described to date recognize epitopes within the highly immunogenic -chain tandem repeat. Because the -chain is shed, such Abs are sequestered and fail to reach MUC1-expressing cells. Immunizing with cDNA encoding MUC1/TM and the spliced MUC1/X isoform from which the tandem repeat has been deleted yielded antibodies to the MUC1 / junction. Pseudomonas toxin PE38 linked to polyclonal anti-MUC1 / junction Abs both bound and killed MUC1-positive malignant cells. Monoclonal DMC209 binds the MUC1 / junction in both MUC1/X and MUC1/TM. When injected into SCID mice xenotransplanted with human breast cancer MDA-MB-231, monoclonal DMC209 showed significant in vivo tumor-suppressive activity. The MUC1/X / junction presents a biologically-significant target in MUC1-expressing malignancies because (i) antibodies directed against cell-bound / junction epitopes reach the intended cellular target, (ii) antibodies to junction epitope are internalized into cells, (iii) anti / junction antibodies can effectively kill high MUC1-expressing cancer cells as antibody-toxin conjugates and (iv) antibodies targeting the MUC1 cell-bound / junction results in tumor suppression in vivo. Our results indicate that cell-bound MUC1 / junction, unlike shed alpha chain, represents a highly effective moiety for targeting and killing MUC1-expressing malignancies. JF - International Journal of Cancer AU - Rubinstein, Daniel B AU - Karmely, Maya AU - Pichinuk, Edward AU - Ziv, Ravit AU - Benhar, Itai AU - Feng, Ningping AU - Smorodinsky, Nechama I AU - Wreschner, Daniel H AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, danielhw@post.tau.ac.il Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 46 EP - 54 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 1 SN - 0020-7136, 0020-7136 KW - Microbiology Abstracts B: Bacteriology; Oncogenes & Growth Factors Abstracts; Immunology Abstracts KW - Cell surface KW - Antibodies KW - Malignancy KW - Immunogenicity KW - mucin KW - Breast cancer KW - Pseudomonas KW - Tumors KW - Epitopes KW - Immunotoxins KW - Toxins KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - J 02350:Immunology KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20628111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Neural+and+cardiac+toxicities+associated+with+3%2C4-methylenedioxymethamphetamine+%28MDMA%29.&rft.au=Baumann%2C+Michael+H%3BRothman%2C+Richard+B&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988010-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell surface; Malignancy; Antibodies; Immunogenicity; mucin; Breast cancer; Tumors; Toxins; Immunotoxins; Epitopes; Pseudomonas DO - http://dx.doi.org/10.1002/ijc.23910 ER - TY - JOUR T1 - Serum pepsinogens and risk of esophageal squamous dysplasia AN - 20627474; 9356061 AB - Pepsinogens are a class of endopeptidases that are secreted by the gastric epithelium and released into the circulation. Low serum pepsinogen I (PGI) and low serum pepsinogen I/pepsinogen II ratio (PGI/II ratio) are markers of gastric fundic atrophy, and have recently been shown to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). We conducted the current study to test whether these markers are also associated with esophageal squamous dysplasia (ESD), the precursor lesion of ESCC. We measured serum PGI and PGII, using enzyme-linked immunosorbent assays, in 125 case subjects (patients with moderate or severe ESD) and 250 sex-matched control subjects (no ESD) selected from an endoscopic screening study in Linxian, China. We used conditional logistic regression models adjusted for age, smoking and place of residence to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Serum PGI showed no statistically significant association with ESD, whether analyzed as a dichotomous, ordinal (quartiles) or continuous variable. Lower serum PGI/II ratio, however, showed a dose-response association with increased risk of ESD, with an adjusted OR (95% CI) of 2.12 (1.08-4.18), comparing the lowest versus the highest quartile. The association between the lower serum PGI/II ratio and log OR of ESD was nearly linear, and the p-value for the continuous association was 0.03. Lower serum PGI/II ratio was linearly associated with higher risk of ESD. This result is consistent with recent findings that gastric atrophy may increase the risk of ESCC. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Kamangar, Farin AU - Diaw, Lena AU - Wei, Wen-Qiang AU - Abnet, Christian C AU - Wang, Guo-Qing AU - Roth, Mark J AU - Liu, Bing AU - Lu, Ning AU - Giffen, Carol AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, kamangaf@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 456 EP - 460 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 2 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Smoking KW - Age KW - Dose-response effects KW - Lesions KW - China, People's Rep. KW - medical instruments KW - Immunoassays KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20627474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Serum+pepsinogens+and+risk+of+esophageal+squamous+dysplasia&rft.au=Kamangar%2C+Farin%3BDiaw%2C+Lena%3BWei%2C+Wen-Qiang%3BAbnet%2C+Christian+C%3BWang%2C+Guo-Qing%3BRoth%2C+Mark+J%3BLiu%2C+Bing%3BLu%2C+Ning%3BGiffen%2C+Carol%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2009-01-01&rft.volume=124&rft.issue=2&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23918 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Age; Dose-response effects; Lesions; medical instruments; Immunoassays; Cancer; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.23918 ER - TY - JOUR T1 - A prospective study of loss of control eating for body weight gain in children at high risk for adult obesity AN - 20556254; 9268159 AB - Objective Limited data suggest that disordered-eating may predispose children to excessive weight gain. We investigated the relationship between baseline responses to the Eating Disorder Examination adapted for Children (ChEDE) and change in BMI (kg/m2) in children at high risk for adult obesity. Method Children (6-12 years) were administered the ChEDE to assess loss of control (LOC) eating, dietary restraint, and eating, shape, and weight concern. Height and weight were measured at baseline and annually. Results Between July, 1999, and August, 2007, 772 measurements were obtained from 143 children over 4.5 ± 1.9 years. LOC eating predicted an increased rate of BMI growth over time (p = .02). Compared with children without LOC, those reporting LOC gained an additional mean 2.4 kg of weight per year. Conclusion LOC is a salient predictor of weight gain during middle childhood. Interventions that decrease LOC eating should be evaluated for their ability to prevent excessive pediatric weight gain. JF - International Journal of Eating Disorders AU - Tanofsky-Kraff, Marian AU - Yanovski, Susan Z AU - Schvey, Natasha A AU - Olsen, Cara H AU - Gustafson, Jennifer AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), DHHS, Bethesda, Maryland, mtanofsky@usuhs.edu Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 26 EP - 30 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 42 IS - 1 SN - 0276-3478, 0276-3478 KW - Physical Education Index; Risk Abstracts KW - Diets KW - Measurement KW - Obesity KW - Eating disorders KW - Body mass KW - obesity KW - Diet (weight control) KW - Height KW - Adults KW - Children KW - eating disorders KW - intervention KW - Objectives KW - body weight KW - R2 23110:Psychological aspects KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20556254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Eating+Disorders&rft.atitle=A+prospective+study+of+loss+of+control+eating+for+body+weight+gain+in+children+at+high+risk+for+adult+obesity&rft.au=Tanofsky-Kraff%2C+Marian%3BYanovski%2C+Susan+Z%3BSchvey%2C+Natasha+A%3BOlsen%2C+Cara+H%3BGustafson%2C+Jennifer%3BYanovski%2C+Jack+A&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2009-01-01&rft.volume=42&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Eating+Disorders&rft.issn=02763478&rft_id=info:doi/10.1002%2Feat.20580 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Measurement; Eating disorders; Objectives; Body mass; Diet (weight control); Height; Adults; Children; Diets; eating disorders; intervention; obesity; body weight DO - http://dx.doi.org/10.1002/eat.20580 ER - TY - JOUR T1 - Crystallization and preliminary X-ray diffraction analyses of several forms of the CfaB major subunit of enterotoxigenic Escherichia coli CFA/I fimbriae AN - 20548261; 9256686 AB - Enterotoxigenic Escherichia coli (ETEC), a major global cause of diarrhea, initiates the pathogenic process via fimbriae-mediated attachment to the small intestinal epithelium. A common prototypic ETEC fimbria, colonization factor antigen I (CFA/I), consists of a tip-localized minor adhesive subunit CfaE and the stalk-forming major subunit CfaB, both of which are necessary for fimbrial assembly. To elucidate the structure of CFA/I at atomic resolution, three recombinant proteins were generated consisting of fusions of the minor and major subunits (CfaEB) and of two (CfaBB) and three (CfaBBB) repeats of the major subunit. Crystals of CfaEB diffracted X-rays to 2.1Aa resolution and displayed the symmetry of space group P21. CfaBB exhibited a crystal diffraction limit of 2.3Aa resolution and had the symmetry of space group P21212. CfaBBB crystallized in the monoclinic space group C2 and diffracted X-rays to 2.3Aa resolution. These structures were determined using the molecular-replacement method. JF - Acta Crystallographica Section F AU - Li, Yong-Fu AU - Poole, Steven AU - Rasulova, Fatima AU - McVeigh, Annette L AU - Savarino, Stephen J AU - Xia, Di AD - aLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4256, USA, dixia@helix.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 242 EP - 247 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 65 IS - 3 SN - 1744-3091, 1744-3091 KW - Microbiology Abstracts B: Bacteriology KW - colonization factor antigen I fimbriae KW - CfaB subunit KW - enterotoxigenic Escherichia coli KW - Crystallization KW - Diarrhea KW - Crystals KW - X-ray diffraction KW - Pili KW - Ionizing radiation KW - Escherichia coli KW - Intestine KW - Epithelium KW - Adhesives KW - Fimbria KW - Colonization factor KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20548261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+F&rft.atitle=Crystallization+and+preliminary+X-ray+diffraction+analyses+of+several+forms+of+the+CfaB+major+subunit+of+enterotoxigenic+Escherichia+coli+CFA%2FI+fimbriae&rft.au=Li%2C+Yong-Fu%3BPoole%2C+Steven%3BRasulova%2C+Fatima%3BMcVeigh%2C+Annette+L%3BSavarino%2C+Stephen+J%3BXia%2C+Di&rft.aulast=Li&rft.aufirst=Yong-Fu&rft.date=2009-01-01&rft.volume=65&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+F&rft.issn=17443091&rft_id=info:doi/10.1107%2FS1744309109001584 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Crystallization; Diarrhea; Pili; Ionizing radiation; Intestine; Epithelium; Crystals; Adhesives; X-ray diffraction; Colonization factor; Escherichia coli; Fimbria DO - http://dx.doi.org/10.1107/S1744309109001584 ER - TY - JOUR T1 - The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations AN - 20525737; 9210011 AB - The realization that there exists a multimembered family of cation channels with structural similarity to Drosophila's Trp channel emerged during the second half of the 1990s. In mammals, depending on the species, the TRP family counts 29 or 30 members which has been subdivided into 6 subfamilies on the basis of sequence similarity. TRP channels are nonselective monovalent cation channels, most of which also allow passage of Ca super(2+). Many members of each of these families, but not all, are involved in sensory signal transduction. The C-type (for canonical or classical) subfamily, differs from the other TRP subfamilies in that it fulfills two different types of function: membrane depolarization, resembling sensory transduction TRPs, and mediation of sustained increases in intracellular Ca super(2+). The mechanism(s) by which the C-class of TRP channels-the TRPCs-are activated is poorly understood and their role in mediating intracellular Ca super(2+) increases is being questioned. Both of these questions-mechanism of activation and participation in Ca super(2+) entry-are the topics of this review. JF - Annual Review of Pharmacology and Toxicology AU - Birnbaumer, Lutz AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, birnbau1@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 395 EP - 426 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 49 SN - 0362-1642, 0362-1642 KW - Entomology Abstracts; Calcium & Calcified Tissue Abstracts; Toxicology Abstracts KW - cation channels KW - Calcium KW - Reviews KW - Ion channels KW - transient receptor potential proteins KW - sensory transduction KW - Drosophila KW - Calcium (intracellular) KW - Signal transduction KW - Membrane potential KW - Depolarization KW - Z 05300:General KW - X 24310:Pharmaceuticals KW - T 2000:Cellular Calcium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20525737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Pharmacology+and+Toxicology&rft.atitle=The+TRPC+Class+of+Ion+Channels%3A+A+Critical+Review+of+Their+Roles+in+Slow%2C+Sustained+Increases+in+Intracellular+Ca2%2B+Concentrations&rft.au=Birnbaumer%2C+Lutz&rft.aulast=Birnbaumer&rft.aufirst=Lutz&rft.date=2009-01-01&rft.volume=49&rft.issue=&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Pharmacology+and+Toxicology&rft.issn=03621642&rft_id=info:doi/10.1146%2Fannurev.pharmtox.48.113006.094928 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - cation channels; Calcium; Reviews; Ion channels; sensory transduction; transient receptor potential proteins; Depolarization; Membrane potential; Signal transduction; Calcium (intracellular); Drosophila DO - http://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094928 ER - TY - JOUR T1 - Cancer Screening: The Clash of Science and Intuition AN - 20525618; 9209921 AB - The concept of early detection of cancer holds great promise and intuitive appeal. However, powerful biases can mislead clinicians when evaluating the efficacy of screening tests by clinical observation alone. Selection bias, lead-time bias, length-biased sampling, and overdiagnosis are counterintuitive concepts with critical implications for early-detection efforts. This article explains these biases and other common confounders in cancer screening. The most direct and reliable way to avoid being led astray by intuitions is through the use of randomized controlled trials. JF - Annual Review of Medicine AU - Kramer, Barnett S AU - Croswell, Jennifer Miller AD - Office of Disease Prevention, Office of the Director, National Institutes of Health, Bethesda, Maryland 20892, bk76p@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 125 EP - 137 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 60 SN - 0066-4219, 0066-4219 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Sampling KW - Clinical trials KW - Cancer KW - Lead KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20525618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=Cancer+Screening%3A+The+Clash+of+Science+and+Intuition&rft.au=Kramer%2C+Barnett+S%3BCroswell%2C+Jennifer+Miller&rft.aulast=Kramer&rft.aufirst=Barnett&rft.date=2009-01-01&rft.volume=60&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.60.101107.134802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reviews; Sampling; Clinical trials; Lead; Cancer DO - http://dx.doi.org/10.1146/annurev.med.60.101107.134802 ER - TY - JOUR T1 - Gene by Environment Interaction in Asthma AN - 20523682; 9209898 AB - Marked international differences in rates of asthma and allergies and the importance of family history highlight the primacy of interactions between genetic variation and the environment in asthma etiology. Environmental tobacco smoke (or secondhand smoke), ambient air pollutants, and endotoxin and/or other pathogen-associated molecular patterns are the ambient exposures studied most frequently for interactions with genetic polymorphisms in asthma. To date, results from the literature remain inconclusive. Most published studies are underpowered to study interactions between genetic polymorphisms and ambient exposures, each with weak effects. Strategies to increase power include cooperation across studies to increase sample sizes and improve measures of both exposure and asthma phenotypes. Genome-wide association studies hold promise for identifying unexpected gene environment interactions, but given the statistical power issues, candidate gene association studies will remain important. New tools are enabling the study of epigenetic mechanisms for environmental interactions. JF - Annual Review of Public Health AU - London, Stephanie J AU - Romieu, Isabelle AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, london2@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 55 EP - 80 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 30 SN - 0163-7525, 0163-7525 KW - Genetics Abstracts; Pollution Abstracts; Immunology Abstracts KW - Air pollution KW - Allergies KW - Asthma KW - Cooperation KW - Endotoxins KW - Etiology KW - Gene polymorphism KW - Genetic diversity KW - Genetics KW - Hypersensitivity KW - Passive smoking KW - Pollutants KW - Public health KW - Respiratory diseases KW - Reviews KW - Smoke KW - Statistics KW - Tobacco KW - epigenetics KW - genetic diversity KW - P 0000:AIR POLLUTION KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20523682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Public+Health&rft.atitle=Gene+by+Environment+Interaction+in+Asthma&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Public+Health&rft.issn=01637525&rft_id=info:doi/10.1146%2Fannurev.publhealth.031308.100151 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Endotoxins; Etiology; Statistics; Gene polymorphism; Cooperation; Asthma; Genetic diversity; Public health; Smoke; Hypersensitivity; Pollutants; epigenetics; Reviews; Tobacco; Air pollution; Genetics; Passive smoking; genetic diversity; Respiratory diseases; Allergies DO - http://dx.doi.org/10.1146/annurev.publhealth.031308.100151 ER - TY - JOUR T1 - The HapMap and Genome-Wide Association Studies in Diagnosis and Therapy AN - 20523645; 9209944 AB - The International HapMap Project produced a genome-wide database of human genetic variation for use in genetic association studies of common diseases. The initial output of these studies has been overwhelming, with over 150 risk loci identified in studies of more than 60 common diseases and traits. These associations have suggested previously unsuspected etiologic pathways for common diseases that will be of use in identifying new therapeutic targets and developing targeted interventions based on genetically defined risk. Here we examine the development and application of the HapMap to genome-wide association (GWA) studies; present and future technologies for GWA research; current major efforts in GWA studies; successes and limitations of the GWA approach in identifying polymorphisms related to complex diseases; data release and privacy polices; use of these findings by clinicians, the public, and academic physicians; and sources of ongoing authoritative information on this rapidly evolving field. JF - Annual Review of Medicine AU - Manolio, Teri A AU - Collins, Francis S AD - National Human Genome Research Institute, Bethesda, Maryland 20892, manolio@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 443 EP - 456 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 60 SN - 0066-4219, 0066-4219 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Databases KW - Data processing KW - Reviews KW - Genetic diversity KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20523645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=The+HapMap+and+Genome-Wide+Association+Studies+in+Diagnosis+and+Therapy&rft.au=Manolio%2C+Teri+A%3BCollins%2C+Francis+S&rft.aulast=Manolio&rft.aufirst=Teri&rft.date=2009-01-01&rft.volume=60&rft.issue=&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.60.061907.093117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Reviews; Genetic diversity DO - http://dx.doi.org/10.1146/annurev.med.60.061907.093117 ER - TY - JOUR T1 - Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS AN - 20509142; 9199172 AB - Objectives: To determine the incidence and outcomes of intensive care unit-acquired neuromyopathy and to investigate the role of methylprednisolone in survivors of persistent acute lung injury. Design: Secondary analysis of completed randomized placebo-controlled trial. Setting: Twenty-five hospitals in the NHLBI ARDS Network. Patients and participants: Patients enrolled in the ARDS Network study of methylprednisolone versus placebo for persistent ARDS who survived 60 days or to hospital discharge. Measurements and results: One hundred and twenty-eight study patients survived 60 days. Forty-three (34%) of these patients had evidence by chart review of ICU-acquired neuromyopathy, which was associated with prolonged mechanical ventilation, return to mechanical ventilation, and delayed return to home after critical illness. Treatment with methylprednisolone was not significantly associated with an increase in risk of neuromyopathy (OR 1.5; 95% CI 0.7-3.2). Conclusions: ICU-acquired-neuromyopathy is common among survivors of persistent ARDS and is associated with poorer clinical outcomes. We did not find a significant association between methylprednisolone treatment and neuromyopathy. Limitations of this study preclude definitive conclusions about the causal relationship between corticosteroids and ICU-acquired neuromuscular dysfunction. JF - Intensive Care Medicine AU - Hough, Catherine L AU - Steinberg, Kenneth P AU - Taylor Thompson, B AU - Rubenfeld, Gordon D AU - Hudson, Leonard D AD - Department of Medicine and The NHLBI ARDS Network, University of Washington, 325 Ninth Avenue, Mailstop 359762, Seattle, WA, 98104, USA, cterrlee@u.washington.edu Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 63 EP - 68 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 VL - 35 IS - 1 SN - 0342-4642, 0342-4642 KW - Risk Abstracts KW - Ventilation KW - Injuries KW - Lung KW - secondary analysis KW - Reviews KW - corticoids KW - Hospitals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20509142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Intensive+care+unit-acquired+neuromyopathy+and+corticosteroids+in+survivors+of+persistent+ARDS&rft.au=Hough%2C+Catherine+L%3BSteinberg%2C+Kenneth+P%3BTaylor+Thompson%2C+B%3BRubenfeld%2C+Gordon+D%3BHudson%2C+Leonard+D&rft.aulast=Hough&rft.aufirst=Catherine&rft.date=2009-01-01&rft.volume=35&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-008-1304-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Injuries; Ventilation; secondary analysis; Lung; Reviews; Hospitals; corticoids DO - http://dx.doi.org/10.1007/s00134-008-1304-4 ER - TY - JOUR T1 - Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity AN - 20400879; 9076905 AB - Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of single-nucleotide polymorphisms (SNPs) on benzene-induced hematotoxicity, we analyzed 1395 SNPs in 411 genes using an Illumina GoldenGate assay in 250 benzene-exposed workers and 140 unexposed controls. Highly significant findings clustered in five genes (BLM, TP53, RAD51, WDR79 and WRN) that play a critical role in DNA repair and genomic maintenance, and these regions were then further investigated with tagSNPs. One or more SNPs in each gene were associated with highly significant 10-20% reductions (P values ranged from 0.0011 to 0.0002) in the white blood cell (WBC) count among benzene-exposed workers but not controls, with evidence for gene-environment interactions for SNPs in BLM, WRN and RAD51. Further, among workers exposed to benzene, the genotype-associated risk of having a WBC count [Lt]4000 cells/kl increased when using individuals with progressively higher WBC counts as the comparison group, with some odds ratios >>8-fold. In vitro functional studies revealed that deletion of SGS1 in yeast, equivalent to lacking BLM and WRN function in humans, caused reduced cellular growth in the presence of the toxic benzene metabolite hydroquinone, and knockdown of WRN using specific short hairpin RNA increased susceptibility of human TK6 cells to hydroquinone toxicity. Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity. JF - Carcinogenesis AU - Lan, Qing AU - Zhang, Luoping AU - Shen, Min AU - Jo, William J AU - Vermeulen, Roel AU - Li, Guilan AU - Vulpe, Christopher AU - Lim, Sophia AU - Ren, Xuefeng AU - Rappaport, Stephen M AU - Berndt, Sonja I AU - Yeager, Meredith AU - Yuenger, Jeff AU - Hayes, Richard B AU - Linet, Martha AU - Yin, Songnian AU - Chanock, Stephen AU - Smith, Martyn T AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, qingl@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 50 EP - 58 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 30 IS - 1 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Leukocytes KW - Hydroquinone KW - Metabolites KW - Toxicity KW - DNA repair KW - Benzene KW - p53 protein KW - Workers KW - RNA KW - Single-nucleotide polymorphism KW - Carcinogenesis KW - genomics KW - homologous recombination KW - N 14820:DNA Metabolism & Structure KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20400879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Large-scale+evaluation+of+candidate+genes+identifies+associations+between+DNA+repair+and+genomic+maintenance+and+development+of+benzene+hematotoxicity&rft.au=Lan%2C+Qing%3BZhang%2C+Luoping%3BShen%2C+Min%3BJo%2C+William+J%3BVermeulen%2C+Roel%3BLi%2C+Guilan%3BVulpe%2C+Christopher%3BLim%2C+Sophia%3BRen%2C+Xuefeng%3BRappaport%2C+Stephen+M%3BBerndt%2C+Sonja+I%3BYeager%2C+Meredith%3BYuenger%2C+Jeff%3BHayes%2C+Richard+B%3BLinet%2C+Martha%3BYin%2C+Songnian%3BChanock%2C+Stephen%3BSmith%2C+Martyn+T%3BRothman%2C+Nathaniel&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn249 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hydroquinone; Leukocytes; Metabolites; Toxicity; DNA repair; Benzene; p53 protein; Workers; RNA; Single-nucleotide polymorphism; Carcinogenesis; genomics; homologous recombination DO - http://dx.doi.org/10.1093/carcin/bgn249 ER - TY - JOUR T1 - Correspondence: Asthma and obesity: An archival addendum AN - 20397448; 9068720 AB - Abstract not available. JF - Journal of Allergy and Clinical Immunology AU - Cohen, Sheldon G AD - National Institute of Allergy and Infectious Diseases and the National Library of Medicine, History of Medicine Division, National Institutes of Health, Bethesda, Md, scohen@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 265 EP - 266 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA, [mailto:membership@aaaai.org], [URL:http://www.aaai.org] VL - 123 IS - 1 SN - 0091-6749, 0091-6749 KW - Physical Education Index KW - Obesity KW - Immune system KW - Asthma KW - Allergies KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Correspondence%3A+Asthma+and+obesity%3A+An+archival+addendum&rft.au=Cohen%2C+Sheldon+G&rft.aulast=Cohen&rft.aufirst=Sheldon&rft.date=2009-01-01&rft.volume=123&rft.issue=1&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2008.07.038 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Immune system; Asthma; Allergies DO - http://dx.doi.org/10.1016/j.jaci.2008.07.038 ER - TY - JOUR T1 - Direct and Indirect Impairment of Human Dendritic Cell Function by Virulent Francisella tularensis Schu S4 AN - 20383919; 9065249 AB - The gram-negative, facultative intracellular bacterium Francisella tularensis causes acute, lethal pneumonic disease following infection with only 10 CFU. The mechanisms used by the bacterium to accomplish this in humans are unknown. Here, we demonstrate that virulent, type A F. tularensis strain Schu S4 efficiently infects and replicates in human myeloid dendritic cells (DCs). Despite exponential replication over time, Schu S4 failed to stimulate transforming growth factor b, interleukin-10 (IL-10), IL-6, IL-1b, IL-12, tumor necrosis factor alpha, alpha interferon (IFN-a), and IFN-b throughout the course of infection. Schu S4 also suppressed the ability of directly infected DCs to respond to different Toll-like receptor agonists. Furthermore, we also observed functional inhibition of uninfected bystander cells. This inhibition was mediated, in part, by a heat-stable bacterial component. Lipopolysaccharide (LPS) from Schu S4 was present in Schu S4-conditioned medium. However, Schu S4 LPS was weakly inflammatory and failed to induce suppression of DCs at concentrations below 10 kg/ml, and depletion of Schu S4 LPS did not significantly alleviate the inhibitory effect of Schu S4-conditioned medium in uninfected human DCs. Together, these data show that type A F. tularensis interferes with the ability of a central cell type of the immune system, DCs, to alert the host of infection both intra- and extracellularly. This suggests that immune dysregulation by F. tularensis operates on a broader and more comprehensive scale than previously appreciated. JF - Infection and Immunity AU - Chase, Jennifer C AU - Celli, Jean AU - Bosio, Catharine M AD - Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 180 EP - 195 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Data processing KW - Replication KW - Immune system KW - Interleukin 1 KW - Francisella tularensis KW - Tumor necrosis factor-a KW - Infection KW - Interleukin 10 KW - Inflammation KW - b-Interferon KW - Interleukin 12 KW - Dendritic cells KW - Colony-forming cells KW - Transforming growth factor-b KW - Lipopolysaccharides KW - Thermal stability KW - Toll-like receptors KW - a-Interferon KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20383919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Direct+and+Indirect+Impairment+of+Human+Dendritic+Cell+Function+by+Virulent+Francisella+tularensis+Schu+S4&rft.au=Chase%2C+Jennifer+C%3BCelli%2C+Jean%3BBosio%2C+Catharine+M&rft.aulast=Chase&rft.aufirst=Jennifer&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Data processing; Replication; Immune system; Interleukin 1; Infection; Tumor necrosis factor-a; Interleukin 10; Inflammation; b-Interferon; Dendritic cells; Interleukin 12; Colony-forming cells; Lipopolysaccharides; Transforming growth factor-b; Thermal stability; a-Interferon; Toll-like receptors; Francisella tularensis ER - TY - JOUR T1 - Sustained Activation of Akt and Erk1/2 Is Required for Coxiella burnetii Antiapoptotic Activity AN - 20381927; 9065252 AB - Coxiella burnetii is an obligate intracellular bacterial pathogen that directs biogenesis of a lysosome-like, parasitophorous vacuole in mammalian cells. We recently reported that C. burnetii inhibits apoptotic cell death in macrophages, presumably as a mechanism to sustain the host for completion of its lengthy infectious cycle. In the current study, we further investigated C. burnetii manipulation of host cell signaling and apoptosis by examining the effect of C. burnetii infection on activation of 15 host proteins involved in stress responses, cytokine production, and apoptosis. C. burnetii infection of THP-1 human macrophage-like cells caused increased levels of phosphorylated c-Jun, Hsp27, Jun N-terminal protein kinase, and p38 at 2 h postinfection (hpi), and this activation rapidly decreased to near basal levels by 24 hpi. The prosurvival kinases Akt and Erk1/2 (extracellular signal-regulated kinases 1 and 2) were also activated at 2 to 6 hpi; however, the phosphorylation of these proteins increased coincident with C. burnetii replication through at least 72 hpi. Sustained phosphorylation of Akt and Erk1/2 was abolished by treatment of infected cells with rifampin, indicating their activation is a C. burnetii-directed event requiring pathogen RNA synthesis. Moreover, pharmacological inhibition of Akt or Erk1/2 significantly decreased C. burnetii antiapoptotic activity. Collectively, these results indicate the importance of C. burnetii modulation of host signaling and demonstrate a critical role for Akt and Erk1/2 in successful intracellular parasitism and maintenance of host cell viability. JF - Infection and Immunity AU - Voth, Daniel E AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 205 EP - 213 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Intracellular signalling KW - Apoptosis KW - Replication KW - Transcription KW - Pathogens KW - c-Jun protein KW - Infection KW - Parasitism KW - Cell activation KW - parasitophorous vacuole KW - Coxiella burnetii KW - Rifampin KW - Extracellular signal-regulated kinase KW - Phosphorylation KW - Mammalian cells KW - Hsp27 protein KW - Transcription factors KW - AKT protein KW - Protein kinase KW - Cytokines KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20381927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Sustained+Activation+of+Akt+and+Erk1%2F2+Is+Required+for+Coxiella+burnetii+Antiapoptotic+Activity&rft.au=Voth%2C+Daniel+E%3BHeinzen%2C+Robert+A&rft.aulast=Voth&rft.aufirst=Daniel&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Intracellular signalling; Apoptosis; Replication; Transcription; Pathogens; Infection; c-Jun protein; Parasitism; Cell activation; parasitophorous vacuole; Extracellular signal-regulated kinase; Rifampin; Mammalian cells; Phosphorylation; Transcription factors; Hsp27 protein; AKT protein; Cytokines; Protein kinase; Signal transduction; Coxiella burnetii ER - TY - JOUR T1 - Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers AN - 20375883; 9061822 AB - Lower molecular weight polybrominated diphenyl ethers (PBDEs), components of flame retardants, are found in the environment and in human and animal tissues. Toxicity studies were conducted in F344/N rats and B6C3F1 mice by administering a flame retardant containing these lower molecular weight PBDEs (BDE-47, BDE-99, BDE-100, and BDE153) by oral gavage 5 days/week for 13 weeks at doses of 0.01, 5, 50, 100 or 500 mg/kg/day. Liver was the primary target organ in rats and mice. Treatment-related increases in liver weights, liver cytochrome P450 (1A1, 1A2, 2B) and UDPGT (rats only) levels, and liver lesions were seen in both rats and mice. Hepatocyte hypertrophy and vacuolization increased in incidence and severity with treatment, and occurred at levels of 50 mg/kg and above in rats, and at 100 mg/kg and above in mice. Liver Cyp 1A1, 1A2, and 2B levels were increased at exposure levels of 50 mg/kg and above in rats and mice. In addition, treatment-related thyroid lesions occurred particularly in rats. The most sensitive parameter for PBDE toxicity was the increase in liver weights which occurred at 5 mg/kg above in rats and 50 mg/kg and above in mice. These results suggest that liver may be a target organ for carcinogenesis processes after long-term administration of PBDEs. A chronic PBDE study is currently being conducted by the National Toxicology Program. JF - Experimental and Toxicologic Pathology AU - Dunnick, June K AU - Nyska, Abraham AD - National Institute of Environmental Health Sciences, Research Triangle Park, P.O. Box 12233, NC 27709, USA, dunnickj@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 1 EP - 12 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 61 IS - 1 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Flame retardant KW - Polybrominated diphenyl ethers KW - Liver toxicity KW - polybrominated diphenyl ethers KW - Hypertrophy KW - Hepatocytes KW - Molecular weight KW - Carcinogenesis KW - Liver KW - Thyroid KW - Fire retardant chemicals KW - Toxicity KW - Cytochrome P450 KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20375883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=Characterization+of+liver+toxicity+in+F344%2FN+rats+and+B6C3F1+mice+after+exposure+to+a+flame+retardant+containing+lower+molecular+weight+polybrominated+diphenyl+ethers&rft.au=Dunnick%2C+June+K%3BNyska%2C+Abraham&rft.aulast=Dunnick&rft.aufirst=June&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2008.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hypertrophy; polybrominated diphenyl ethers; Hepatocytes; Molecular weight; Carcinogenesis; Thyroid; Liver; Cytochrome P450; Toxicity; Fire retardant chemicals DO - http://dx.doi.org/10.1016/j.etp.2008.06.008 ER - TY - JOUR T1 - Multiecho dixon fat and water separation method for detecting fibrofatty infiltration in the myocardium AN - 20373610; 9058293 AB - Conventional approaches for fat and water discrimination based on chemical-shift fat suppression have reduced ability to characterize fatty infiltration due to poor contrast of microscopic fat. The multiecho Dixon approach to water and fat separation has advantages over chemical-shift fat suppression: 1) water and fat images can be acquired in a single breathhold, avoiding misregistration; 2) fat has positive contrast; 3) the method is compatible with precontrast and late-enhancement imaging, 4) less susceptible to partial-volume effects, and 5) robust in the presence of background field variation; and 6) for the bandwidth implemented, chemical-shift artifact is decreased. The proposed technique was applied successfully in all 28 patients studied. This included 10 studies with indication of coronary artery disease (CAD), of which four cases with chronic myocardial infarction (MI) exhibited fatty infiltration; 13 studies to rule out arrhythmogenic right ventricular cardiomyopathy (ARVC), of which there were three cases with fibrofatty infiltration and two confirmed with ARVC; and five cases of cardiac masses (two lipomas). The precontrast contrast-to-noise ratio (CNR) of intramyocardial fat was greatly improved, by 240% relative to conventional fat suppression. For the parameters implemented, the signal-to-noise ratio (SNR) was decreased by 30% relative to conventional late enhancement. The multiecho Dixon method for fat and water separation provides a sensitive means of detecting intramyocardial fat with positive signal contrast. Magn Reson Med 61:215-221, 2009. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Hernando, Diego AU - Shah, Saurabh AU - Zuehlsdorff, Sven AU - Jerecic, Renate AU - Mancini, Christine AU - Liang, Zhi-Pei AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS), Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 215 EP - 221 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 61 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Cardiomyopathy KW - Ventricle KW - N.M.R. KW - lipoma KW - imaging KW - Myocardial infarction KW - Heart diseases KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Multiecho+dixon+fat+and+water+separation+method+for+detecting+fibrofatty+infiltration+in+the+myocardium&rft.au=Kellman%2C+Peter%3BHernando%2C+Diego%3BShah%2C+Saurabh%3BZuehlsdorff%2C+Sven%3BJerecic%2C+Renate%3BMancini%2C+Christine%3BLiang%2C+Zhi-Pei%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21657 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Cardiomyopathy; Ventricle; N.M.R.; lipoma; imaging; Myocardial infarction; Myocardium; Heart diseases DO - http://dx.doi.org/10.1002/mrm.21657 ER - TY - JOUR T1 - Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States AN - 20368472; 9054542 AB - Objective: Immunosuppression may increase risk for some skin cancers. We evaluated skin cancer epidemiology among persons with AIDS. Design: We linked data from population-based US AIDS and cancer registries to evaluate risk of nonkeratinocytic skin cancers (melanoma, Merkel cell carcinoma, and appendageal carcinomas, including sebaceous carcinoma) in 497142 persons with AIDS. Methods: Standardized incidence ratios (SIRs) were calculated to relate skin cancer risk to that in the general population. We used logistic regression to compare risk according to demographic factors, CD4 cell count, and a geographic index of ultraviolet radiation exposure. Results: From 60 months before to 60 months after AIDS onset, persons with AIDS had elevated risks of melanoma (SIR = 1.3, 95% confidence interval 1.1-1.4, n = 292 cases) and, more strongly, of Merkel cell carcinoma (SIR= 11, 95% confidence interval 6.3-17, n = 17) and sebaceous carcinoma (SIR = 8.1, 95% confidence interval 3.2-17, n = 7). Risk for appendageal carcinomas increased with progressive time relative to AIDS onset (P trend = 0.03). Risk of these skin cancers was higher in non-Hispanic whites than other racial/ethnic groups, and melanoma risk was highest among men who have sex with men. Melanoma risk was unrelated to CD4 cell count at AIDS onset (P=0.32). Risks for melanoma and appendageal carcinomas rose with increasing ultraviolet radiation exposure (P trend <10 super(-4) and P trend = 10 super(-3), respectively). Conclusion: Among persons with AIDS, there is a modest excess risk of melanoma, which is not strongly related to immunosuppression and may relate to ultraviolet radiation exposure. In contrast, the greatly increased risks for Merkel cell and sebaceous carcinoma suggest an etiologic role for immunosuppression. JF - AIDS AU - Lanoy, E AU - Dores, G M AU - Madeleine, M M AU - Toro, J R AU - Fraumeni, JF Jr AU - Engels, E A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 7076, Rockville, MD 20892, USA, engelse@exchange.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 385 EP - 393 VL - 23 IS - 3 SN - 0269-9370, 0269-9370 KW - Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - demography KW - Acquired immune deficiency syndrome KW - homosexuality KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - Skin cancer KW - Melanoma KW - Demography KW - CD4 antigen KW - U.V. radiation KW - Risk factors KW - Ultraviolet radiation KW - Ethnic groups KW - Skin KW - Data processing KW - melanoma KW - Cancer KW - Carcinoma KW - USA KW - Epidemiology KW - Standards KW - Immunosuppression KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20368472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Epidemiology+of+nonkeratinocytic+skin+cancers+among+persons+with+AIDS+in+the+United+States&rft.au=Lanoy%2C+E%3BDores%2C+G+M%3BMadeleine%2C+M+M%3BToro%2C+J+R%3BFraumeni%2C+JF+Jr%3BEngels%2C+E+A&rft.aulast=Lanoy&rft.aufirst=E&rft.date=2009-01-01&rft.volume=23&rft.issue=3&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e3283213046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Demography; CD4 antigen; Acquired immune deficiency syndrome; Data processing; U.V. radiation; Epidemiology; Risk factors; Skin cancer; Ethnic groups; Immunosuppression; Melanoma; Carcinoma; demography; Skin; Ultraviolet radiation; homosexuality; Standards; melanoma; Cancer; USA; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir DO - http://dx.doi.org/10.1097/QAD.0b013e3283213046 ER - TY - JOUR T1 - Research paper: Induction of lactoferrin gene expression by innate immune stimuli in mouse mammary epithelial HC-11 cells AN - 20346492; 9011899 AB - Lactoferrin (LF) is a multifunctional protein. While its functions and mechanism of actions are actively being investigated, the cellular signals that regulate LF expression have not been as explored. We have previously demonstrated that LF is upregulated by estrogen in the reproductive system. In this study, we show that the expression of LF was stimulated by bacterial lipopolysaccharide (LPS) and double-stranded RNA (dsRNA) in normal mouse mammalian HC-11 cells. When cells were exposed to either LPS or dsRNA, the mRNA and protein of LF were increased in a dose - and time-dependent manner, yet the kinetics of LF induction by dsRNA or LPS were different. The LPS and dsRNA-induced LF was mainly released into the culture medium where it blocked TNF-a production in exposed cells. We explored the mechanisms of LF induction by LPS and dsRNA using specific inhibitors and found that the induction could be attenuated by inhibitors to PKC, NF-kB, p38 and JNK, but not by an inhibitor to PKA. Interestingly, ERK inhibitor was effective against dsRNA but not against LPS induction of LF. These data suggest that LF was induced by LPS and dsRNA through PKC, NF-kB and MAPK pathways which in turn play an inhibitory role in the continuation of innate inflammation. JF - Biochimie AU - Li, Yin AU - Limmon, Gino V AU - Imani, Farhad AU - Teng, Christina AD - Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA, teng1@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 58 EP - 67 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 91 IS - 1 SN - 0300-9084, 0300-9084 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Lactoferrin KW - LPS KW - dsRNA KW - HC-11 cells KW - PKC KW - MAPK KW - NF-kB KW - Inhibitors KW - Protein kinase C KW - Protein kinase A KW - MAP kinase KW - Estrogens KW - c-Jun amino-terminal kinase KW - Data processing KW - Double-stranded RNA KW - Cell culture KW - Tumor necrosis factor-a KW - Reproductive system KW - Inflammation KW - Gene expression KW - Extracellular signal-regulated kinase KW - Kinetics KW - lactoferrin KW - NF-B protein KW - Lipopolysaccharides KW - J 02310:Genetics & Taxonomy KW - W 30940:Products KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimie&rft.atitle=Research+paper%3A+Induction+of+lactoferrin+gene+expression+by+innate+immune+stimuli+in+mouse+mammary+epithelial+HC-11+cells&rft.au=Li%2C+Yin%3BLimmon%2C+Gino+V%3BImani%2C+Farhad%3BTeng%2C+Christina&rft.aulast=Li&rft.aufirst=Yin&rft.date=2009-01-01&rft.volume=91&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Biochimie&rft.issn=03009084&rft_id=info:doi/10.1016%2Fj.biochi.2008.04.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Estrogens; MAP kinase; Protein kinase A; Data processing; c-Jun amino-terminal kinase; Double-stranded RNA; Cell culture; Tumor necrosis factor-a; Reproductive system; Inflammation; Gene expression; Extracellular signal-regulated kinase; Kinetics; NF-B protein; lactoferrin; Lipopolysaccharides DO - http://dx.doi.org/10.1016/j.biochi.2008.04.014 ER - TY - JOUR T1 - A novel signaling pathway impact analysis AN - 20302503; 8921174 AB - Motivation: Gene expression class comparison studies may identify hundreds or thousands of genes as differentially expressed (DE) between sample groups. Gaining biological insight from the result of such experiments can be approached, for instance, by identifying the signaling pathways impacted by the observed changes. Most of the existing pathway analysis methods focus on either the number of DE genes observed in a given pathway (enrichment analysis methods), or on the correlation between the pathway genes and the class of the samples (functional class scoring methods). Both approaches treat the pathways as simple sets of genes, disregarding the complex gene interactions that these pathways are built to describe.Results: We describe a novel signaling pathway impact analysis (SPIA) that combines the evidence obtained from the classical enrichment analysis with a novel type of evidence, which measures the actual perturbation on a given pathway under a given condition. A bootstrap procedure is used to assess the significance of the observed total pathway perturbation. Using simulations we show that the evidence derived from perturbations is independent of the pathway enrichment evidence. This allows us to calculate a global pathway significance P-value, which combines the enrichment and perturbation P-values. We illustrate the capabilities of the novel method on four real datasets. The results obtained on these data show that SPIA has better specificity and more sensitivity than several widely used pathway analysis methods.Availability: SPIA was implemented as an R package available at http://vortex.cs.wayne.edu/ontoexpress/: Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Tarca, Adi Laurentiu AU - Draghici, Sorin AU - Khatri, Purvesh AU - Hassan, Sonia S AU - Mittal, Pooja AU - Kim, Jung-sun AU - Kim, Chong Jai AU - Kusanovic, Juan Pedro AU - Romero, Roberto AD - 1 Department of Computer Science, Wayne State University, 431 State Hall, Detroit, MI 48202 and 2 Perinatology Research Branch-NIH-NICHD, 4 Brush, 3990 John R, Detroit, MI 48201, USA, sorin@wayne.edu Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 75 EP - 82 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 1 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - Bioinformatics KW - Signal transduction KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=A+novel+signaling+pathway+impact+analysis&rft.au=Tarca%2C+Adi+Laurentiu%3BDraghici%2C+Sorin%3BKhatri%2C+Purvesh%3BHassan%2C+Sonia+S%3BMittal%2C+Pooja%3BKim%2C+Jung-sun%3BKim%2C+Chong+Jai%3BKusanovic%2C+Juan+Pedro%3BRomero%2C+Roberto&rft.aulast=Tarca&rft.aufirst=Adi&rft.date=2009-01-01&rft.volume=25&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn577 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Bioinformatics; Signal transduction DO - http://dx.doi.org/10.1093/bioinformatics/btn577 ER - TY - JOUR T1 - Evidence for Translocation of Microbial Products in Patients with Idiopathic CD4 Lymphocytopenia AN - 20187983; 10190598 AB - Translocation of microbial products has been described in chronic human immunodeficiency virus (HIV) infection and correlates with activation of the immune system. We investigated the potential translocation of microbial products in idiopathic CD4 lymphocytopenia (ICL), a rare disorder characterized by low CD4 T cell counts in the absence of HIV infection. Plasma lipopolysaccharide (LPS) levels and T cell activation were measured in a cross-sectional cohort study of patients with ICL and HIV infection and healthy control subjects. Increases in CD4 T cell proliferation but not CD8 T cell proliferation were observed in patients with ICL. LPS levels were significantly elevated both in patients with ICL and in patients with HIV infection, and they were strongly correlated with the proportion of proliferating CD4 T cells in the cohort of patients with ICL ([image] ; [image]). The proportions of T helper (Th) 17 and Th1 CD4 cells in peripheral blood were similar between patients with ICL, patients with HIV infection, and control subjects. These findings suggest a potential association of translocation of microbial products with perturbed CD4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection. JF - Journal of Infectious Diseases AU - Lee, Philip I AU - Ciccone, Emily J AU - Read, Sarah W AU - Asher, Ava AU - Pitts, Robert AU - Douek, Daniel C AU - Brenchley, Jason M AU - Sereti, Irini AD - Laboratory of Immunoregulation, Clinical and Molecular Retrovirology Section, Division of AIDS, Human Immunology Section, Vaccine Research Center, and Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, isereti@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1664 EP - 1670 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 11 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Helper cells KW - Immune system KW - Lymphopenia KW - Peripheral blood KW - Homeostasis KW - CD8 antigen KW - Cell activation KW - CD4 antigen KW - Human immunodeficiency virus KW - Chronic infection KW - Lymphocytes T KW - Lipopolysaccharides KW - Cell proliferation KW - Translocation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20187983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Evidence+for+Translocation+of+Microbial+Products+in+Patients+with+Idiopathic+CD4+Lymphocytopenia&rft.au=Lee%2C+Philip+I%3BCiccone%2C+Emily+J%3BRead%2C+Sarah+W%3BAsher%2C+Ava%3BPitts%2C+Robert%3BDouek%2C+Daniel+C%3BBrenchley%2C+Jason+M%3BSereti%2C+Irini&rft.aulast=Lee&rft.aufirst=Philip&rft.date=2009-01-01&rft.volume=199&rft.issue=11&rft.spage=1664&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F598953 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Immune system; Helper cells; Lymphopenia; Peripheral blood; CD8 antigen; Homeostasis; Cell activation; CD4 antigen; Chronic infection; Lymphocytes T; Lipopolysaccharides; Cell proliferation; Translocation; Human immunodeficiency virus DO - http://dx.doi.org/10.1086/598953 ER - TY - JOUR T1 - Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1 AN - 20083906; 10095116 JF - Advances in Enzyme Regulation AU - Shears, Stephen B AD - Inositol Signaling Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, USA, shears@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 87 EP - 96 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 49 IS - 1 SN - 0065-2571, 0065-2571 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - inositol phosphate KW - Enzymes KW - Signal transduction KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20083906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Sex+Differences+in+WISC-III+Profiles+of+Children+with+High-functioning+Pervasive+Developmental+Disorders&rft.au=Koyama%2C+Tomonori%3BKamio%2C+Yoko%3BInada%2C+Naoko%3BKurita%2C+Hiroshi&rft.aulast=Koyama&rft.aufirst=Tomonori&rft.date=2009-01-01&rft.volume=39&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0610-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Integration; inositol phosphate; Enzymes; Signal transduction DO - http://dx.doi.org/10.1016/j.advenzreg.2008.12.008 ER - TY - JOUR T1 - Acute but not Chronic Donepezil Increases Muscarinic Receptor-Mediated Signaling via Arachidonic Acid in Unanesthetized Rats AN - 20073920; 10081595 AB - Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Muscarinic receptors are coupled to cytosolic phospholipase A_{2} (cPLA_{2}) activation and arachidonic acid (AA) release from synaptic membrane phospholipid. This activation can be imaged in rodents as an AA incorporation coefficient k*, using quantitative autoradiography. Acute and chronic effects of donepezil on the AA signal, k* for AA, were measured in 81 brain regions of unanesthetized rats. Twenty min after a single oral dose (3.0 mg/kg) of donepezil, k* was increased significantly in 37 brain regions, whereas k* did not differ from control 7 h afterwards or following chronic (21 days) of donepezil. Pretreatment with atropine prevented the 20-min increments in k* following donepezil. Donepezil also increased the brain ACh concentration and reduced brain AChE activity, but did not change cPLA_{2} activity, regardless of administration regimen. These results show that donepezil acutely increases the brain AA signal that is mediated by ACh acting at muscarinic receptors, but that this signal is rapidly desensitized despite continued elevated brain ACh concentration. In contrast, the AA signal in response to arecoline was not altered following donepezil. JF - Journal of Alzheimer's Disease AU - Basselin, Mireille AU - Nguyen, Henry N AU - Chang, Lisa AU - Bell, Jane M AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 369 EP - 382 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG The Netherlands VL - 17 IS - 2 SN - 1387-2877, 1387-2877 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Phospholipase A2 KW - Acetylcholinesterase KW - Alzheimer's disease KW - Acetylcholine receptors (muscarinic) KW - Brain KW - Arachidonic acid KW - donepezil KW - Acetylcholine receptors KW - Autoradiography KW - Neurodegenerative diseases KW - Synaptic membranes KW - Chronic effects KW - Acetylcholine KW - Phospholipids KW - Signal transduction KW - Atropine KW - X 24310:Pharmaceuticals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20073920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+Disease&rft.atitle=Acute+but+not+Chronic+Donepezil+Increases+Muscarinic+Receptor-Mediated+Signaling+via+Arachidonic+Acid+in+Unanesthetized+Rats&rft.au=Basselin%2C+Mireille%3BNguyen%2C+Henry+N%3BChang%2C+Lisa%3BBell%2C+Jane+M%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2009-01-01&rft.volume=17&rft.issue=2&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+Alzheimer%27s+Disease&rft.issn=13872877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Acetylcholinesterase; Phospholipase A2; Acetylcholine receptors (muscarinic); Alzheimer's disease; Brain; Arachidonic acid; donepezil; Autoradiography; Acetylcholine receptors; Neurodegenerative diseases; Synaptic membranes; Chronic effects; Acetylcholine; Atropine; Signal transduction; Phospholipids ER - TY - JOUR T1 - Clinical and Dosimetric Predictors of Acute Toxicity After a 4-Week Hypofractionated External Beam Radiotherapy Regimen for Prostate Cancer: Results From a Multicentric Prospective Trial AN - 19700886; 9068317 AB - To investigate predictors for gastrointestinal (GI) and genitourinary (GU) acute toxicity after a short-course hypofractionated radiotherapy regimen for prostate cancer. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Arcangeli, Stefano AU - Strigari, Lidia AU - Soete, Guy AU - De Meerleer, Gert AU - Gomellini, Sara AU - Fonteyne, Valerie AU - Storme, Guy AU - Arcangeli, Giorgio AD - Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy, stefano.arcangeli@yahoo.it Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 39 EP - 45 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 73 IS - 1 SN - 0360-3016, 0360-3016 KW - Toxicology Abstracts KW - Prostate cancer KW - Radiotherapy KW - Hypofractionation KW - Acute toxicity KW - BED KW - Clinical trials KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19700886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Clinical+and+Dosimetric+Predictors+of+Acute+Toxicity+After+a+4-Week+Hypofractionated+External+Beam+Radiotherapy+Regimen+for+Prostate+Cancer%3A+Results+From+a+Multicentric+Prospective+Trial&rft.au=Arcangeli%2C+Stefano%3BStrigari%2C+Lidia%3BSoete%2C+Guy%3BDe+Meerleer%2C+Gert%3BGomellini%2C+Sara%3BFonteyne%2C+Valerie%3BStorme%2C+Guy%3BArcangeli%2C+Giorgio&rft.aulast=Arcangeli&rft.aufirst=Stefano&rft.date=2009-01-01&rft.volume=73&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2008.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Prostate cancer; Radiotherapy; Acute toxicity; Clinical trials DO - http://dx.doi.org/10.1016/j.ijrobp.2008.04.005 ER - TY - JOUR T1 - Origins of Stochasticity and Burstiness in High-Dimensional Biochemical Networks AN - 19515792; 8830178 AB - Two major approaches are known in the field of stochastic dynamics of intracellular biochemical networks. The first one places the focus of attention on the fact that many biochemical constituents vitally important for the network functionality may be present only in small quantities within the cell, and therefore the regulatory process is essentially discrete and prone to relatively big fluctuations. The second approach treats the regulatory process as essentially continuous. Complex pseudostochastic behavior in such processes may occur due to multistability and oscillatory motions within limit cycles. In this paper we outline the third scenario of stochasticity in the regulatory process. This scenario is only conceivable in high-dimensional highly nonlinear systems. In particular, we show that burstiness, a well-known phenomenon in the biology of gene expression, is a natural consequence of high dimensionality coupled with high nonlinearity. In mathematical terms, burstiness is associated with heavy-tailed probability distributions of stochastic processes describing the dynamics of the system. We demonstrate how the 'shot' noise originates from purely deterministic behavior of the underlying dynamical system. We conclude that the limiting stochastic process may be accurately approximated by the 'heavy-tailed' generalized Pareto process which is a direct mathematical expression of burstiness. JF - Eurasip Journal on Bioinformatics and Systems Biology AU - Rosenfeld, Simon AD - Division of Cancer Prevention (DCP) National Cancer Institute EPN 3108 6130 Executive Blvd Bethesda MO 20892, rosenfes@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 PB - Hindawi Publishing Corporation, P.O. Box 3079 VL - 2009 SN - 1687-4145, 1687-4145 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - Bioinformatics KW - nonlinear systems KW - Stochasticity KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.atitle=Origins+of+Stochasticity+and+Burstiness+in+High-Dimensional+Biochemical+Networks&rft.au=Rosenfeld%2C+Simon&rft.aulast=Rosenfeld&rft.aufirst=Simon&rft.date=2009-01-01&rft.volume=2009&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.issn=16874145&rft_id=info:doi/10.1155%2F2009%2F362309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stochasticity; Computer programs; nonlinear systems; Gene expression; Bioinformatics DO - http://dx.doi.org/10.1155/2009/362309 ER - TY - JOUR T1 - Evaluation of random forests performance for genome-wide association studies in the presence of interaction effects AN - 1034820738; 16899279 AB - Random forests (RF) is one of a broad class of machine learning methods that are able to deal with large-scale data without model specification, which makes it an attractive method for genome-wide association studies (GWAS). The performance of RF and other association methods in the presence of interactions was evaluated using the simulated data from Genetic Analysis Workshop 16 Problem 3, with knowledge of the major causative markers, risk factors, and their interactions in the simulated traits. There was good power to detect the environmental risk factors using RF, trend tests, or regression analyses but the power to detect the effects of the causal markers was poor for all methods. The causal marker that had an interactive effect with smoking did show moderate evidence of association in the RF and regression analyses, suggesting that RF may perform well at detecting such interactions in larger, more highly powered datasets. JF - BMC Proceedings AU - Kim, Yoonhee AU - Wojciechowski, Robert AU - Sung, Heejong AU - Mathias, Rasika A AU - Wang, Li AU - Klein, Alison P AU - Lenroot, Rhoshel K AU - Malley, James AU - Bailey-Wilson, Joan E AD - National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 3 IS - Suppl 7 SN - 1753-6561, 1753-6561 KW - Risk Abstracts KW - Forests KW - Risk factors KW - Smoking KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034820738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Proceedings&rft.atitle=Evaluation+of+random+forests+performance+for+genome-wide+association+studies+in+the+presence+of+interaction+effects&rft.au=Kim%2C+Yoonhee%3BWojciechowski%2C+Robert%3BSung%2C+Heejong%3BMathias%2C+Rasika+A%3BWang%2C+Li%3BKlein%2C+Alison+P%3BLenroot%2C+Rhoshel+K%3BMalley%2C+James%3BBailey-Wilson%2C+Joan+E&rft.aulast=Kim&rft.aufirst=Yoonhee&rft.date=2009-01-01&rft.volume=3&rft.issue=Suppl+7&rft.spage=S64&rft.isbn=&rft.btitle=&rft.title=BMC+Proceedings&rft.issn=17536561&rft_id=info:doi/ L2 - http://www.biomedcentral.com/1753-6561/3/S7/S64 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 11 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Smoking; Risk factors; Forests ER - TY - JOUR T1 - Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. AN - 69932278; 19104039 AB - A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive nuclear factor-kappaB (NF-kappaB) signaling for survival. Small molecule inhibitors of IkappaB kinase beta (IKKbeta), a key regulator of the NF-kappaB pathway, kill ABC DLBCL cells and hold promise for the treatment of this lymphoma type. We conducted an RNA interference genetic screen to investigate potential mechanisms of resistance of ABC DLBCL cells to IKKbeta inhibitors. We screened a library of small hairpin RNAs (shRNAs) targeting 500 protein kinases for shRNAs that would increase the killing of an ABC DLBCL cell line in the presence of a small molecule IKKbeta inhibitor. Two independent shRNAs targeting IKKalpha synergized with the IKKbeta inhibitor to kill three different ABC DLBCL cell lines but were not toxic by themselves. Surprisingly, IKKalpha shRNAs blocked the classical rather than the alternative NF-kappaB pathway in ABC DLBCL cells, as judged by inhibition of IkappaBalpha phosphorylation. IKKalpha shRNA toxicity was reversed by coexpression of wild-type but not kinase inactive forms of IKKalpha, suggesting that IKKalpha may directly phosphorylate IkappaBalpha under conditions of IKKbeta inhibition. In models of physiologic NF-kappaB pathway activation by CARD11 or tumor necrosis factor-alpha, compensatory IKKalpha activity was also observed with IKKbeta inhibition. These results suggest that therapy for ABC DLBCL may be improved by targeting both IKKalpha and IKKbeta, possibly through CARD11 inhibition. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Lam, Lloyd T AU - Davis, R Eric AU - Ngo, Vu N AU - Lenz, Georg AU - Wright, George AU - Xu, Weihong AU - Zhao, Hong AU - Yu, Xin AU - Dang, Lenny AU - Staudt, Louis M AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12/30/ PY - 2008 DA - 2008 Dec 30 SP - 20798 EP - 20803 VL - 105 IS - 52 KW - CARD Signaling Adaptor Proteins KW - 0 KW - NF-kappa B KW - Protein Kinase Inhibitors KW - Tumor Necrosis Factor-alpha KW - I-kappa B Kinase KW - EC 2.7.11.10 KW - CARD11 protein, human KW - EC 4.6.1.2 KW - Guanylate Cyclase KW - Index Medicus KW - Guanylate Cyclase -- metabolism KW - Humans KW - CARD Signaling Adaptor Proteins -- metabolism KW - Jurkat Cells KW - Drug Delivery Systems -- methods KW - Tumor Necrosis Factor-alpha -- metabolism KW - RNA Interference KW - Drug Screening Assays, Antitumor -- methods KW - Phosphorylation -- drug effects KW - I-kappa B Kinase -- metabolism KW - I-kappa B Kinase -- antagonists & inhibitors KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- pharmacology KW - Signal Transduction -- drug effects KW - Lymphoma, Large B-Cell, Diffuse -- enzymology KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69932278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Compensatory+IKKalpha+activation+of+classical+NF-kappaB+signaling+during+IKKbeta+inhibition+identified+by+an+RNA+interference+sensitization+screen.&rft.au=Lam%2C+Lloyd+T%3BDavis%2C+R+Eric%3BNgo%2C+Vu+N%3BLenz%2C+Georg%3BWright%2C+George%3BXu%2C+Weihong%3BZhao%2C+Hong%3BYu%2C+Xin%3BDang%2C+Lenny%3BStaudt%2C+Louis+M&rft.aulast=Lam&rft.aufirst=Lloyd&rft.date=2008-12-30&rft.volume=105&rft.issue=52&rft.spage=20798&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0806491106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2000 Jul 15;165(2):804-12 [10878354] Blood. 2008 Apr 1;111(7):3701-13 [18160665] J Biol Chem. 2000 Aug 25;275(34):25883-91 [10823818] Science. 2000 Sep 1;289(5484):1550-4 [10968790] Mol Cell. 2001 Feb;7(2):401-9 [11239468] Science. 2001 Mar 16;291(5511):2162-5 [11251123] Nature. 2001 Jul 19;412(6844):346-51 [11460167] Science. 2001 Aug 24;293(5534):1495-9 [11520989] Genome Biol. 2001;2(10):RESEARCH0041 [11597333] Cell. 2001 Dec 14;107(6):763-75 [11747812] J Exp Med. 2001 Dec 17;194(12):1861-74 [11748286] Nat Immunol. 2002 Sep;3(9):830-5 [12154356] J Exp Med. 2002 Sep 16;196(6):743-52 [12235208] Nat Immunol. 2002 Oct;3(10):958-65 [12352969] EMBO J. 2002 Oct 15;21(20):5375-85 [12374738] J Immunol. 2003 May 1;170(9):4630-7 [12707341] Nature. 2003 Jun 5;423(6940):659-63 [12789343] Nat Rev Drug Discov. 2004 Jan;3(1):17-26 [14708018] Mol Cell. 2004 May 7;14(3):289-301 [15125833] Mol Cell. 2004 Aug 27;15(4):535-48 [15327770] Immunity. 2004 Oct;21(4):477-89 [15485626] Cell. 1997 Oct 17;91(2):243-52 [9346241] Science. 1998 Aug 28;281(5381):1360-3 [9721103] Science. 1999 Apr 9;284(5412):309-13 [10195894] Science. 1999 Apr 9;284(5412):321-5 [10195897] Clin Cancer Res. 2005 Jan 1;11(1):28-40 [15671525] Adv Immunol. 2005;87:163-208 [16102574] J Exp Med. 2005 Nov 21;202(10):1423-31 [16301747] Immunity. 2005 Dec;23(6):561-74 [16356855] Immunity. 2005 Dec;23(6):575-85 [16356856] Nature. 2006 May 4;441(7089):106-10 [16572121] J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001 [16525037] Blood. 2006 Jun 1;107(11):4266-73 [16439676] Mol Cell. 2006 Jul 7;23(1):13-23 [16818229] Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):908-13 [17213322] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6359-64 [17404218] Cancer Cell. 2007 Aug;12(2):115-30 [17692804] Cell. 2007 Sep 7;130(5):918-31 [17803913] Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3503-8 [18292232] Science. 2008 Mar 21;319(5870):1676-9 [18323416] Genes Dev. 2000 Jul 15;14(14):1729-33 [10898787] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0806491106 ER - TY - JOUR T1 - Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families. AN - 66650840; 19111067 AB - Disulphide bridges are well known to play key roles in stability, folding and functions of proteins. Introduction or deletion of disulphides by site-directed mutagenesis have produced varying effects on stability and folding depending upon the protein and location of disulphide in the 3-D structure. Given the lack of complete understanding it is worthwhile to learn from an analysis of extent of conservation of disulphides in homologous proteins. We have also addressed the question of what structural interactions replaces a disulphide in a homologue in another homologue. Using a dataset involving 34,752 pairwise comparisons of homologous protein domains corresponding to 300 protein domain families of known 3-D structures, we provide a comprehensive analysis of extent of conservation of disulphide bridges and their structural features. We report that only 54% of all the disulphide bonds compared between the homologous pairs are conserved, even if, a small fraction of the non-conserved disulphides do include cytoplasmic proteins. Also, only about one fourth of the distinct disulphides are conserved in all the members in protein families. We note that while conservation of disulphide is common in many families, disulphide bond mutations are quite prevalent. Interestingly, we note that there is no clear relationship between sequence identity between two homologous proteins and disulphide bond conservation. Our analysis on structural features at the sites where cysteines forming disulphide in one homologue are replaced by non-Cys residues show that the elimination of a disulphide in a homologue need not always result in stabilizing interactions between equivalent residues. We observe that in the homologous proteins, disulphide bonds are conserved only to a modest extent. Very interestingly, we note that extent of conservation of disulphide in homologous proteins is unrelated to the overall sequence identity between homologues. The non-conserved disulphides are often associated with variable structural features that were recruited to be associated with differentiation or specialisation of protein function. JF - BMC structural biology AU - Thangudu, Ratna R AU - Manoharan, Malini AU - Srinivasan, N AU - Cadet, Frédéric AU - Sowdhamini, R AU - Offmann, Bernard AD - Laboratoire de Biochimie et Génétique Moléculaire, Université de La Réunion, BP 7151, 15 avenue René Cassin, 97715 Saint Denis Messag Cedex 09, La Réunion, France. thangudr@ncbi.nlm.nih.gov Y1 - 2008/12/26/ PY - 2008 DA - 2008 Dec 26 SP - 55 VL - 8 KW - Disulfides KW - 0 KW - Proteins KW - Solvents KW - Cystine KW - 48TCX9A1VT KW - Index Medicus KW - Cystine -- chemistry KW - Solvents -- chemistry KW - Sequence Alignment KW - Conserved Sequence KW - Databases, Protein KW - Protein Structure, Tertiary KW - Protein Conformation KW - Structural Homology, Protein KW - Disulfides -- chemistry KW - Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66650840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+structural+biology&rft.atitle=Analysis+on+conservation+of+disulphide+bonds+and+their+structural+features+in+homologous+protein+domain+families.&rft.au=Thangudu%2C+Ratna+R%3BManoharan%2C+Malini%3BSrinivasan%2C+N%3BCadet%2C+Fr%C3%A9d%C3%A9ric%3BSowdhamini%2C+R%3BOffmann%2C+Bernard&rft.aulast=Thangudu&rft.aufirst=Ratna&rft.date=2008-12-26&rft.volume=8&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=BMC+structural+biology&rft.issn=1472-6807&rft_id=info:doi/10.1186%2F1472-6807-8-55 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-16 N1 - Date created - 2009-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Eng. 2002 Dec;15(12):951-3 [12601133] Protein Eng. 2003 Mar;16(3):187-93 [12702798] Proteins. 2003 Oct 1;53(1):1-5 [12945044] Annu Rev Biochem. 2003;72:111-35 [12524212] J Mol Biol. 2004 Jan 23;335(4):1083-92 [14698301] Biol Chem. 2003 Dec;384(12):1553-63 [14719797] J Biol Chem. 2004 Mar 5;279(10):9298-305 [14613939] Bioinformatics. 2004 Mar 22;20(5):653-9 [15033872] Biochem Biophys Res Commun. 2004 May 21;318(1):142-7 [15110765] Proteins. 2004 Jun 1;55(4):1036-42 [15146500] Trends Biochem Sci. 1989 Jul;14(7):304-9 [2672455] Protein Eng. 1989 Nov;3(2):95-103 [2594728] Protein Eng. 1990 Jul;3(7):591-8 [1699222] Protein Eng. 1990 Aug;3(8):667-72 [2217140] Proteomics. 2004 Jun;4(6):1665-71 [15174135] Protein Eng Des Sel. 2004 Apr;17(4):367-73 [15166311] J Mol Biol. 1971 Feb 14;55(3):379-400 [5551392] Nature. 1976 Jun 17;261(5561):552-8 [934293] Adv Protein Chem. 1981;34:167-339 [7020376] Adv Protein Chem. 1981;34:61-92 [6266231] J Mol Biol. 1981 Sep 15;151(2):261-87 [7338898] J Biochem. 1983 Sep;94(3):997-1007 [6643433] Biopolymers. 1983 Dec;22(12):2577-637 [6667333] Biochemistry. 1985 Mar 12;24(6):1501-9 [3986190] Bioessays. 1988 Feb-Mar;8(2):57-63 [3282505] Science. 1989 Feb 10;243(4892):792-4 [2916125] Protein Eng. 1988 Sep;2(3):193-9 [3237684] Protein Eng. 1988 Jul;2(2):119-25 [3244694] J Mol Biol. 1999 Dec 10;294(4):1027-40 [10588904] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] EMBO J. 2000 Jan 17;19(2):164-73 [10637221] J Mol Biol. 2000 Jan 28;295(4):903-14 [10656799] J Mol Biol. 2000 Mar 17;297(1):233-49 [10704319] Biochemistry. 2000 Apr 18;39(15):4207-16 [10757967] Chem Pharm Bull (Tokyo). 2000 Apr;48(4):480-5 [10783065] Bioinformatics. 2000 Mar;16(3):251-6 [10869018] J Mol Biol. 2000 Jul 21;300(4):975-85 [10891282] J Mol Biol. 2000 Jul 21;300(4):1005-16 [10891285] J Mol Biol. 2000 Aug 11;301(2):433-50 [10926519] J Biomol NMR. 2000 Oct;18(2):165-71 [11101221] Protein Sci. 2000 Oct;9(10):1889-97 [11106161] Structure. 2000 Dec 15;8(12):1267-78 [11188691] Protein Sci. 2000 Dec;9(12):2394-404 [11206061] J Mol Biol. 2001 Mar 23;307(2):671-81 [11254389] Cell. 2001 Apr 6;105(1):103-13 [11301006] Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20 [11331761] J Mol Biol. 2001 Jul 13;310(3):617-34 [11439028] Biochemistry. 2001 Aug 7;40(31):9059-64 [11478871] Bioinformatics. 2001 Aug;17(8):721-8 [11524373] Nat Struct Biol. 2001 Sep;8(9):770-4 [11524679] Structure. 2001 Apr 4;9(4):331-40 [11525170] Bioinformatics. 2001 Oct;17(10):957-64 [11673241] Proteins. 2002 Feb 15;46(3):243-9 [11835499] Protein Eng. 2002 Jan;15(1):59-64 [11842239] Methods Enzymol. 2002;353:10-21 [12078485] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9679-84 [12107280] Protein Sci. 2002 Nov;11(11):2735-9 [12381855] Bioinformatics. 2003 Jan 22;19(2):313-4 [12538266] J Bacteriol. 1991 Dec;173(23):7719-22 [1938970] Methods Enzymol. 1991;202:336-56 [1784181] FEBS Lett. 1992 May 11;302(2):117-20 [1633841] Proteins. 1992 Oct;14(2):309-23 [1409577] Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):597-604 [8224474] Protein Sci. 1993 Oct;2(10):1551-8 [8251931] Protein Sci. 1994 Jan;3(1):92-102 [8142902] J Mol Biol. 1994 Apr 22;238(1):54-61 [8145256] Biochem Mol Biol Int. 1994 Aug;33(6):1049-53 [7804129] J Mol Biol. 1995 Apr 7;247(4):536-40 [7723011] Protein Sci. 1995 Nov;4(11):2405-10 [8563638] J Mol Biol. 1996 Jun 14;259(3):480-501 [8676383] Biochemistry. 1996 Aug 13;35(32):10328-38 [8756688] J Mol Biol. 1996 Dec 6;264(3):603-23 [8969308] Proteins. 1997 Mar;27(3):360-6 [9094738] J Biol Chem. 1997 Jun 20;272(25):15661-7 [9188456] J Mol Biol. 1997 Oct 3;272(4):597-612 [9325115] Biochemistry. 1998 Feb 3;37(5):1292-301 [9477955] Biochemistry. 1998 Sep 29;37(39):13475-85 [9753433] Structure. 1998 Sep 15;6(9):1195-206 [9753698] J Mol Biol. 1998 Oct 30;283(3):657-68 [9784374] J Mol Biol. 1998 Dec 4;284(3):541-8 [9826496] Cell. 1999 Feb 5;96(3):341-52 [10025400] Trends Biochem Sci. 1999 Jan;24(1):34-6 [10087920] Biochem Biophys Res Commun. 1999 Apr 13;257(2):418-24 [10198229] Proteins. 1999 Aug 15;36(3):340-6 [10409827] Proteins. 2005 Mar 1;58(4):866-79 [15645448] J Mol Biol. 2005 Apr 1;347(3):565-81 [15755451] J Biol Chem. 2005 Mar 25;280(12):11387-94 [15642731] Bioinformatics. 2005 Apr 15;21(8):1415-20 [15585533] Bioinformatics. 2005 May 15;21(10):2336-46 [15741247] Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W230-2 [15980459] Proteins. 2005 Nov 15;61(3):535-44 [16184609] Bioinformatics. 2005 Dec 15;21(24):4416-9 [16223789] Proteins. 2007 May 1;67(2):255-61 [17285632] Extremophiles. 2008 Jan;12(1):29-38 [17508126] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1472-6807-8-55 ER - TY - JOUR T1 - Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). AN - 69921605; 19053756 AB - Here, we examine the significance that stereochemistry plays within the clinically relevant Janus kinase 3 (Jak3) inhibitor 1 (CP-690,550). A synthesis of all four enantiopure stereoisomers of the drug was carried out and an examination of each compound revealed that only the enantiopure 3R,4R isomer was capable of blocking Stat5 phosphorylation (Jak3 dependent). Each compound was profiled across a panel of over 350 kinases, which revealed a high level of selectivity for the Jak family kinases for these related compounds. Each stereoisomer retained a degree of binding to Jak3 and Jak2 and the 3R,4S and 3S,4R stereoisomers were further revealed to have binding affinity for selected members of the STE7 and STE20 subfamily of kinases. Finally, an appraisal of the minimum energy conformation of each stereoisomer and molecular docking at Jak3 was performed in an effort to better understand each compounds selectivity and potency profiles. JF - Journal of medicinal chemistry AU - Jiang, Jian-kang AU - Ghoreschi, Kamran AU - Deflorian, Francesca AU - Chen, Zhi AU - Perreira, Melissa AU - Pesu, Marko AU - Smith, Jeremy AU - Nguyen, Dac-Trung AU - Liu, Eric H AU - Leister, William AU - Costanzi, Stefano AU - O'Shea, John J AU - Thomas, Craig J AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA. Y1 - 2008/12/25/ PY - 2008 DA - 2008 Dec 25 SP - 8012 EP - 8018 VL - 51 IS - 24 KW - Piperidines KW - 0 KW - Protein Kinase Inhibitors KW - Pyrimidines KW - Pyrroles KW - tofacitinib KW - 87LA6FU830 KW - JAK2 protein, human KW - EC 2.7.10.2 KW - Janus Kinase 2 KW - Index Medicus KW - Stereoisomerism KW - Models, Molecular KW - Kinetics KW - Humans KW - Models, Chemical KW - Molecular Conformation KW - Inhibitory Concentration 50 KW - Monte Carlo Method KW - Janus Kinase 2 -- chemistry KW - Protein Binding KW - Hydrogen Bonding KW - Drug Design KW - Pyrimidines -- chemical synthesis KW - Protein Kinase Inhibitors -- pharmacology KW - Pyrimidines -- pharmacology KW - Protein Kinase Inhibitors -- chemical synthesis KW - Chemistry, Pharmaceutical -- methods KW - Pyrroles -- pharmacology KW - Pyrroles -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69921605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Examining+the+chirality%2C+conformation+and+selective+kinase+inhibition+of+3-%28%283R%2C4R%29-4-methyl-3-%28methyl%287H-pyrrolo%5B2%2C3-d%5Dpyrimidin-4-yl%29amino%29piperidin-1-yl%29-3-oxopropanenitrile+%28CP-690%2C550%29.&rft.au=Jiang%2C+Jian-kang%3BGhoreschi%2C+Kamran%3BDeflorian%2C+Francesca%3BChen%2C+Zhi%3BPerreira%2C+Melissa%3BPesu%2C+Marko%3BSmith%2C+Jeremy%3BNguyen%2C+Dac-Trung%3BLiu%2C+Eric+H%3BLeister%2C+William%3BCostanzi%2C+Stefano%3BO%27Shea%2C+John+J%3BThomas%2C+Craig+J&rft.aulast=Jiang&rft.aufirst=Jian-kang&rft.date=2008-12-25&rft.volume=51&rft.issue=24&rft.spage=8012&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm801142b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Rheumatol. 2005 May;17(3):305-11 [15838241] Blood. 2005 Aug 1;106(3):996-1002 [15831699] Blood. 2006 Jan 1;107(1):176-83 [16174768] Nat Immunol. 2007 Jan;8(1):25-30 [17179969] Nat Biotechnol. 2008 Jan;26(1):127-32 [18183025] Blood. 2008 Feb 15;111(4):2155-7 [18094329] Expert Opin Ther Targets. 2004 Dec;8(6):613-29 [15584866] J Exp Med. 1995 Jan 1;181(1):399-404 [7528775] Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7307-11 [7638186] Science. 1995 Nov 3;270(5237):794-7 [7481767] Science. 1995 Nov 3;270(5237):797-800 [7481768] Cell. 1998 May 1;93(3):397-409 [9590174] Genome Biol. 2004;5(12):253 [15575979] Science. 2003 Oct 31;302(5646):875-8 [14593182] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm801142b ER - TY - JOUR T1 - Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities. AN - 69907921; 19053760 AB - A number of bis(diazeniumdiolates) that we designed to release up to 4 mol of nitric oxide (NO) and that are structural analogues of the NO prodrug and anticancer lead compound O(2)-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino)diazen-1-ium-1,2- diolate (PABA/NO) were synthesized and studied. A majority of these compounds yielded higher levels of NO, were better inhibitors of proliferation of a number of cancer cell lines, and more rapidly induced substantially increased levels of S-glutathionylation of cellular proteins in comparison with PABA/NO. In most cases, the antiproliferative activity and extents of S-glutathionylation correlated well with levels of intracellular NO release. We report bis(diazeniumdiolates) to be a class of S-glutathionylating agents with potent antiproliferative and S-glutathionylating activity. JF - Journal of medicinal chemistry AU - Andrei, Daniela AU - Maciag, Anna E AU - Chakrapani, Harinath AU - Citro, Michael L AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. dandrei@dom.edu Y1 - 2008/12/25/ PY - 2008 DA - 2008 Dec 25 SP - 7944 EP - 7952 VL - 51 IS - 24 KW - Azo Compounds KW - 0 KW - Nitric Oxide Donors KW - Prodrugs KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Prodrugs -- chemistry KW - HL-60 Cells KW - Humans KW - Nitric Oxide -- chemistry KW - Models, Chemical KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Chemistry, Pharmaceutical -- methods KW - Cell Proliferation KW - Drug Design KW - Nitric Oxide Donors -- chemistry KW - Azo Compounds -- chemistry KW - Glutathione -- chemistry KW - Azo Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69907921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Aryl+bis%28diazeniumdiolates%29%3A+potent+inducers+of+S-glutathionylation+of+cellular+proteins+and+their+in+vitro+antiproliferative+activities.&rft.au=Andrei%2C+Daniela%3BMaciag%2C+Anna+E%3BChakrapani%2C+Harinath%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Andrei&rft.aufirst=Daniela&rft.date=2008-12-25&rft.volume=51&rft.issue=24&rft.spage=7944&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm800831y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Adv Enzymol Relat Areas Mol Biol. 1994;69:1-44 [7817866] Blood. 1992 Oct 15;80(8):1880-4 [1382708] Leuk Res. 1995 Aug;19(8):527-33 [7658698] Methods Enzymol. 1996;268:281-93 [8782594] Chem Res Toxicol. 1997 Jan;10(1):2-18 [9074797] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] Leukemia. 1998 Sep;12(9):1461-6 [9737697] Expert Opin Investig Drugs. 2005 Jul;14(7):835-46 [16022573] Curr Top Med Chem. 2005;5(7):597-601 [16101422] Curr Top Med Chem. 2005;5(7):625-36 [16101424] Mol Pharmacol. 2006 Feb;69(2):501-8 [16288082] J Med Chem. 2006 Feb 9;49(3):1157-64 [16451080] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] Leuk Res. 2006 Oct;30(10):1279-83 [16439016] Drug Resist Updat. 2006 Jun;9(3):157-73 [16822706] Biochem Pharmacol. 2007 May 1;73(9):1257-69 [17098212] Cardiovasc Res. 2007 Jul 15;75(2):220-8 [17451659] Blood. 2007 Jul 15;110(2):709-18 [17384201] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Free Radic Biol Med. 2007 Sep 15;43(6):883-98 [17697933] Curr Opin Pharmacol. 2007 Aug;7(4):398-403 [17611156] Curr Opin Pharmacol. 2007 Aug;7(4):381-91 [17662654] Org Lett. 2007 Oct 25;9(22):4551-4 [17918856] Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3 [18178089] Bioorg Med Chem. 2008 Mar 1;16(5):2657-64 [18060792] Antioxid Redox Signal. 2008 Mar;10(3):445-73 [18092936] J Cardiovasc Pharmacol. 1999 Dec;34(6):879-86 [10598133] J Org Chem. 2001 May 4;66(9):3090-8 [11325274] J Biol Chem. 2001 Dec 21;276(51):47763-6 [11684673] Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5103-6 [12697895] J Cell Physiol. 2003 Dec;197(3):426-34 [14566972] Mol Pharmacol. 2004 May;65(5):1070-9 [15102935] Mol Cancer Ther. 2004 Jun;3(6):709-14 [15210857] J Cell Mol Med. 2004 Apr-Jun;8(2):201-12 [15256068] Free Radic Biol Med. 2004 Sep 15;37(6):735-6 [15304248] Biochem Pharmacol. 1988 Jul 1;37(13):2495-501 [3291879] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Chem Res Toxicol. 1991 Mar-Apr;4(2):131-40 [1782341] Blood. 1995 Aug 1;86(3):1184-95 [7542498] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800831y ER - TY - JOUR T1 - Application of binocular vision technology in anterior cruciate ligament surgical navigation system AN - 20478579; 9175818 AB - Based on the failed surgery due to great drilling location errors in rebuilding the knee anterior cruciate ligament, a method was introduced with binocular stereo vision technology rational planning and C-armed X-ray. A new idea that adopts the gridiron pattern marker to simplify the stereo matching process was presented in the self-developed binocular vision positioning system. The calibrated system detected the distance between the pairs of markers which were within 1.5 m distance from the binocular vision sensing units, and the error was less than 1 mm. The application in the anterior cruciate ligament reconstruction surgery shows that the system is stable, reliable, cost-effective, easy-to-calibrate, with sufficient accuracy and high positioning precision, and can meet the requirements of surgical navigation. JF - Journal of Clinical Rehabilitative Tissue Engineering Research AU - Jin-Bing, X AU - Lei, H AU - Peng-Wei, Z AD - Department of Computer, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China, xiejinbing@immc.edu.cn Y1 - 2008/12/23/ PY - 2008 DA - 2008 Dec 23 SP - 10297 EP - 10300 PB - Publishing House of Journal of Clinical Rehabilitative Tissue Engineering Research VL - 12 IS - 52 SN - 1673-8225, 1673-8225 KW - Biotechnology and Bioengineering Abstracts KW - Reconstruction KW - Vision KW - Surgery KW - Ionizing radiation KW - Drilling KW - anterior cruciate ligament KW - Tissue engineering KW - Knee KW - Binocular vision KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20478579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.atitle=Application+of+binocular+vision+technology+in+anterior+cruciate+ligament+surgical+navigation+system&rft.au=Jin-Bing%2C+X%3BLei%2C+H%3BPeng-Wei%2C+Z&rft.aulast=Jin-Bing&rft.aufirst=X&rft.date=2008-12-23&rft.volume=12&rft.issue=52&rft.spage=10297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.issn=16738225&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Reconstruction; Vision; Ionizing radiation; Surgery; Drilling; anterior cruciate ligament; Tissue engineering; Knee; Binocular vision ER - TY - JOUR T1 - Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. AN - 66674524; 19094236 AB - Dependences on addictive substances are substantially-heritable complex disorders whose molecular genetic bases have been partially elucidated by studies that have largely focused on research volunteers, including those recruited in Baltimore. Maryland. Subjects recruited from the Baltimore site of the Epidemiological Catchment Area (ECA) study provide a potentially-useful comparison group for possible confounding features that might arise from selecting research volunteer samples of substance dependent and control individuals. We now report novel SNP (single nucleotide polymorphism) genome wide association (GWA) results for vulnerability to substance dependence in ECA participants, who were initially ascertained as members of a probability sample from Baltimore, and compare the results to those from ethnically-matched Baltimore research volunteers. We identify substantial overlap between the home address zip codes reported by members of these two samples. We find overlapping clusters of SNPs whose allele frequencies differ with nominal significance between substance dependent vs control individuals in both samples. These overlapping clusters of nominally-positive SNPs identify 172 genes in ways that are never found by chance in Monte Carlo simulation studies. Comparison with data from human expressed sequence tags suggests that these genes are expressed in brain, especially in hippocampus and amygdala, to extents that are greater than chance. The convergent results from these probability sample and research volunteer sample datasets support prior genome wide association results. They fail to support the idea that large portions of the molecular genetic results for vulnerability to substance dependence derive from factors that are limited to research volunteers. JF - BMC medical genetics AU - Johnson, Catherine AU - Drgon, Tomas AU - Liu, Qing-Rong AU - Zhang, Ping-Wu AU - Walther, Donna AU - Li, Chuan-Yun AU - Anthony, James C AU - Ding, Yulan AU - Eaton, William W AU - Uhl, George R AD - Molecular Neurobiology Branch, NIH-IRP (NIDA), Suite 3510, 333 Cassell Drive Baltimore, Maryland 21224, USA. johnsoncat@intra.nida.nih.gov Y1 - 2008/12/18/ PY - 2008 DA - 2008 Dec 18 SP - 113 VL - 9 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Alleles KW - Gene Frequency KW - Humans KW - European Continental Ancestry Group KW - Case-Control Studies KW - Baltimore -- epidemiology KW - Male KW - Female KW - Genome, Human KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66674524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+medical+genetics&rft.atitle=Genome+wide+association+for+substance+dependence%3A+convergent+results+from+epidemiologic+and+research+volunteer+samples.&rft.au=Johnson%2C+Catherine%3BDrgon%2C+Tomas%3BLiu%2C+Qing-Rong%3BZhang%2C+Ping-Wu%3BWalther%2C+Donna%3BLi%2C+Chuan-Yun%3BAnthony%2C+James+C%3BDing%2C+Yulan%3BEaton%2C+William+W%3BUhl%2C+George+R&rft.aulast=Johnson&rft.aufirst=Catherine&rft.date=2008-12-18&rft.volume=9&rft.issue=&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=BMC+medical+genetics&rft.issn=1471-2350&rft_id=info:doi/10.1186%2F1471-2350-9-113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-13 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Behav Med. 1989 Apr;12(2):159-82 [2668531] Nucleic Acids Res. 2009 Jan;37(Database issue):D251-60 [18790807] Control Clin Trials. 1990 Apr;11(2):116-28 [2161310] Br J Addict. 1991 Sep;86(9):1119-27 [1932883] Arch Gen Psychiatry. 1992 Sep;49(9):723-7 [1355337] JAMA. 1995 Dec 13;274(22):1786-92 [7500511] Biol Psychiatry. 1996 Oct 15;40(8):776-84 [8894071] Arch Gen Psychiatry. 2000 Mar;57(3):217-22 [10711906] Arch Gen Psychiatry. 2000 Mar;57(3):261-9 [10711912] Am J Med Genet. 2000 Oct 9;96(5):665-70 [11054775] Am J Hum Genet. 2001 Dec;69(6):1290-300 [11704927] JAMA. 2001 Nov 14;286(18):2315-21 [11710898] JAMA. 2001 Nov 14;286(18):2326-8 [11710901] Genet Med. 2003 Jan-Feb;5(1):35-42 [12544474] Nicotine Tob Res. 2004 Jun;6(3):439-46 [15203777] Addict Behav. 1978;3(3-4):235-41 [735910] Am J Epidemiol. 1979 Apr;109(4):394-9 [443238] J Chronic Dis. 1979;32(9-10):633-8 [489703] Arch Gen Psychiatry. 1981 Apr;38(4):381-9 [6260053] J Chronic Dis. 1983;36(10):725-8 [6630408] Arch Gen Psychiatry. 1984 Oct;41(10):934-41 [6089692] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Control Clin Trials. 1998 Dec;19(6):589-601 [9875838] Cancer Epidemiol Biomarkers Prev. 1999 Apr;8(4 Pt 2):369-75 [10207642] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] J Gen Intern Med. 1999 Sep;14(9):537-46 [10491242] Psychol Med. 2004 Oct;34(7):1239-50 [15697050] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9 [16091475] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53 [16894614] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):918-25 [17099884] Hum Mol Genet. 2007 Jan 1;16(1):24-35 [17158188] BMC Genet. 2007;8:10 [17407593] Biochem Pharmacol. 2008 Jan 1;75(1):98-111 [17764662] Arch Gen Psychiatry. 2008 Mar;65(3):345-55 [18316681] Arch Gen Psychiatry. 2008 Jun;65(6):683-93 [18519826] Ann N Y Acad Sci. 2008 Oct;1141:318-81 [18991966] Am J Epidemiol. 1989 Dec;130(6):1088-100 [2589302] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2350-9-113 ER - TY - JOUR T1 - Age-Related Crossover in Breast Cancer Incidence Rates Between Black and White Ethnic Groups AN - 20301201; 8921345 AB - Background Although breast cancer incidence is higher in black women than in white women among women younger than 40 years, the reverse is true among those aged 40 years or older. This crossover in incidence rates between black and white ethnic groups has been well described, has not been completely understood, and has been viewed as an artifact.Methods To quantify this incidence rate crossover, we examined data for 440653 women with invasive breast cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results database from January 1, 1975, through December 31, 2004. Data on invasive female breast cancers were stratified by race, age at diagnosis, year of diagnosis, and tumor characteristics. Standard descriptive analyses were supplemented with Poisson regression models, age-period-cohort models, and two-component mixture models. All statistical tests were two-sided.Results We observed qualitative (ie, crossing or reversing) interactions between age and race. That is, age-specific incidence rates overall (expressed as number of breast cancers per 100000 woman-years) were higher among black women (15.5) than among white women (13.1) younger than 40 years (difference = 2.4, 95% confidence interval [CI] = 2.4 to 2.4), and then, age-specific rates crossed with rates higher among white women (281.3) than among black women (239.5) aged 40 years or older (difference = 41.8, 95% CI = 41.7 to 41.9). The black-to-white incidence rate crossover was observed for all tumor characteristics assessed, although the crossover occurred at earlier ages of diagnosis for low-risk tumor characteristics than for high-risk tumor characteristics. The incidence rate crossover between ethnic groups was robust (ie, reliable and reproducible) to adjustment for calendar period and birth cohort effects in age-period-cohort models (P [Lt] .001 for difference by race).Conclusion Although this ecologic study cannot determine the individual-level factors responsible for the racial crossover in vital rates, it confirms that the age-related crossover in breast cancer incidence rates between black and white ethnic groups is a robust age-specific effect that is independent of period and cohort effects. JF - Journal of the National Cancer Institute AU - Anderson, William F AU - Rosenberg, Philip S AU - Menashe, Idan AU - Mitani, Aya AU - Pfeiffer, Ruth M AD - Affiliations of authors: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD (WFA, PSR, IM, RMP); Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT (AM), wanderso@mail.nih.gov Y1 - 2008/12/17/ PY - 2008 DA - 2008 Dec 17 SP - 1804 EP - 1814 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 24 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Age KW - Breast cancer KW - tumors KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Age-Related+Crossover+in+Breast+Cancer+Incidence+Rates+Between+Black+and+White+Ethnic+Groups&rft.au=Anderson%2C+William+F%3BRosenberg%2C+Philip+S%3BMenashe%2C+Idan%3BMitani%2C+Aya%3BPfeiffer%2C+Ruth+M&rft.aulast=Anderson&rft.aufirst=William&rft.date=2008-12-17&rft.volume=100&rft.issue=24&rft.spage=1804&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn411 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Breast cancer; tumors; Ethnic groups; Cancer DO - http://dx.doi.org/10.1093/jnci/djn411 ER - TY - JOUR T1 - Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies. AN - 69900391; 19057013 AB - Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse skin carcinogenesis both in vitro and in vivo. The current study identifies Sulfiredoxin (Srx) as a unique target of activator protein-1 (AP-1) activation and TAM67 inhibition. Manipulation of Srx levels by ShRNA or over-expression demonstrates that Srx is critical for redox homeostasis through reducing hyperoxidized peroxiredoxins. In JB6 cells, knockdown of Srx abolishes tumor promoter-induced transformation and enhances cell sensitivity to oxidative stress. Knockdown of Srx also impairs c-Jun phosphorylation, implicating a role for Srx in the feedback regulation of AP-1 activity. Screening of patient tissues by tissue microarray reveals elevated Srx expression in several types of human skin cancers. Our study indicates that Srx is a functionally significant target of AP-1 blockade that may have value in cancer prevention or treatment. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Wei, Qiou AU - Jiang, Hong AU - Matthews, Connie P AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2008/12/16/ PY - 2008 DA - 2008 Dec 16 SP - 19738 EP - 19743 VL - 105 IS - 50 KW - Peptide Fragments KW - 0 KW - Peroxides KW - Proto-Oncogene Proteins c-jun KW - RNA, Small Interfering KW - TAM67 peptide KW - Transcription Factor AP-1 KW - Oxidoreductases KW - EC 1.- KW - Oxidoreductases Acting on Sulfur Group Donors KW - EC 1.8.- KW - SRXN1 protein, human KW - EC 1.8.98.2 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Animals KW - Cysteine -- metabolism KW - Peroxides -- metabolism KW - Apoptosis KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Epidermis -- metabolism KW - RNA, Small Interfering -- genetics KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Mice KW - Promoter Regions, Genetic KW - Gene Knockdown Techniques KW - Phosphorylation KW - Oxidative Stress KW - Epidermis -- pathology KW - Skin Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic KW - Oxidoreductases -- genetics KW - Cell Transformation, Neoplastic -- pathology KW - Transcription Factor AP-1 -- metabolism KW - Skin Neoplasms -- pathology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69900391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Sulfiredoxin+is+an+AP-1+target+gene+that+is+required+for+transformation+and+shows+elevated+expression+in+human+skin+malignancies.&rft.au=Wei%2C+Qiou%3BJiang%2C+Hong%3BMatthews%2C+Connie+P%3BColburn%2C+Nancy+H&rft.aulast=Wei&rft.aufirst=Qiou&rft.date=2008-12-16&rft.volume=105&rft.issue=50&rft.spage=19738&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0810676105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-12 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9827-32 [10449779] Science. 1989 May 5;244(4904):566-9 [2541502] J Biol Chem. 2005 Feb 4;280(5):3125-8 [15590625] Nature. 2005 May 19;435(7040):347-53 [15902258] J Biol Chem. 2005 Jun 17;280(24):23319-27 [15824112] J Invest Dermatol. 2000 Dec;115(6):1108-14 [11121149] J Biol Chem. 2002 Nov 8;277(45):43175-84 [12196529] Dev Cell. 2003 Jun;4(6):879-89 [12791272] Nature. 2003 Jul 31;424(6948):561-5 [12891360] Nature. 2003 Oct 30;425(6961):980-4 [14586471] Nature. 1991 Aug 15;352(6336):635-8 [1907719] J Biol Chem. 1993 May 25;268(15):11050-6 [8496166] Genes Dev. 1993 Jul;7(7B):1309-17 [8330736] Nature. 1993 Sep 9;365(6442):179-81 [8371760] Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):609-13 [8290571] Cancer Res. 1994 Mar 1;54(5):1139-44 [8118794] Mol Carcinog. 1994 Nov;11(3):164-9 [7945805] Science. 1994 Dec 9;266(5191):1719-23 [7992057] Cell. 1995 Sep 8;82(5):721-32 [7545543] FEBS Lett. 1998 Feb 13;423(1):39-44 [9506838] Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8875-80 [15956211] J Biol Chem. 2005 Aug 5;280(31):28775-84 [15941719] Oncogene. 2005 Dec 1;24(54):8038-50 [16170382] Trends Mol Med. 2005 Dec;11(12):571-8 [16290020] J Biol Chem. 2006 May 19;281(20):14400-7 [16565085] Cancer Res. 2006 Jul 1;66(13):6800-6 [16818657] Cancer Res. 2006 Jul 15;66(14):7136-42 [16849559] Plant J. 2007 Feb;49(3):505-14 [17217469] Cancer Res. 2007 Mar 15;67(6):2430-8 [17363560] Carcinogenesis. 2007 Nov;28(11):2382-90 [17566060] Nature. 2008 Jan 3;451(7174):98-101 [18172504] Biochem J. 2008 Apr 1;411(1):191-9 [18052930] Oncogene. 2008 Aug 21;27(36):4877-87 [18454177] Cancer Prev Res (Phila). 2008 Jun;1(1):45-55 [19138935] J Biol Chem. 2004 Jan 23;279(4):2535-43 [14597634] Nat Biotechnol. 2004 Mar;22(3):326-30 [14758366] Cell. 2004 May 28;117(5):625-35 [15163410] Cell. 1974 Dec;3(4):355-9 [4442124] Cancer Res. 1978 Mar;38(3):624-34 [626967] Cell. 1987 Jun 19;49(6):741-52 [3034433] Cell. 1988 Dec 2;55(5):875-85 [3142689] J Biol Chem. 2004 Dec 3;279(49):50994-1001 [15448164] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0810676105 ER - TY - JOUR T1 - Antitumor Activity of G3139 Lipid Nanoparticles (LNPs) AN - 754551124; 13305289 AB - G3139, an antisense oligodeoxyribonucleotide (ODN) against Bcl-2, contains two CpG dinucleotides and has shown immunostimulatory activities in preclinical studies. It has been suggested that immunoactivation, rather than antisense activity, is primarily responsible for the therapeutic efficacy of G3139. Nanoparticle formulations naturally target phagocytic antigen presenting cells and therefore might enhance the immunological effects of G3139. In this study, a novel formulation of lipid nanoparticles (LNPs) encapsulating G3139 was synthesized and evaluated in mice bearing L1210 subcutaneous tumors. Intravenous injection of G3139-LNPs into mice led to increased serum levels of IL-6 and IFN-*g, promoted proliferation of natural killer (NK) cells and dendritic cells (DCs), and triggered a strong antitumor immune response in mice. The observed effects were much greater than those induced by free G3139. Correspondingly, the G3139-LNPs more effectively inhibited tumor growth and induced complete tumor regression in some mice. In contrast, free G3139 was ineffective in tumor growth inhibition and did not prolong survival of the tumor-bearing mice. These results suggest that G3139-LNPs are a potential immunomodulatory agent and may have applications in cancer therapy. JF - Molecular Pharmaceutics AU - Pan, Xiaogang AU - Chen, Li AU - Liu, Shujun AU - Yang, Xiaojuan AU - Gao, Jian-Xin AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, NSF Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), Department of Pathology, Department of Internal Medicine, College of Medicine and Public Health, and NCI Comprehensive Cancer Center (CCC), The Ohio State University, Columbus, Ohio 43210 Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 211 EP - 220 PB - American Chemical Society VL - 6 IS - 1 SN - 1543-8384, 1543-8384 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Intravenous administration KW - Lipids KW - Natural killer cells KW - Survival KW - CpG islands KW - Tumors KW - Immunomodulation KW - Oligonucleotides KW - Cancer KW - Serum levels KW - Antisense oligonucleotides KW - Dendritic cells KW - Antisense KW - Phagocytes KW - Immunostimulation KW - Antigen-presenting cells KW - Bcl-2 protein KW - Cell proliferation KW - nanoparticles KW - Antitumor activity KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754551124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Antitumor+Activity+of+G3139+Lipid+Nanoparticles+%28LNPs%29&rft.au=Pan%2C+Xiaogang%3BChen%2C+Li%3BLiu%2C+Shujun%3BYang%2C+Xiaojuan%3BGao%2C+Jian-Xin%3BLee%2C+Robert+J&rft.aulast=Pan&rft.aufirst=Xiaogang&rft.date=2008-12-15&rft.volume=6&rft.issue=1&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp800146j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Intravenous administration; Lipids; Natural killer cells; Survival; Tumors; CpG islands; Oligonucleotides; Immunomodulation; Cancer; Serum levels; Dendritic cells; Antisense oligonucleotides; Antisense; Phagocytes; Immunostimulation; Bcl-2 protein; Antigen-presenting cells; Cell proliferation; nanoparticles; Antitumor activity DO - http://dx.doi.org/10.1021/mp800146j ER - TY - JOUR T1 - Transferrin Receptor-Targeted Lipid Nanoparticles for Delivery of an Antisense Oligodeoxyribonucleotide against Bcl-2 AN - 754549980; 13305290 AB - Antisense oligonucleotide G3139-mediated down-regulation of Bcl-2 is a potential strategy for overcoming chemoresistance in leukemia. However, the limited efficacy shown in recent clinical trials calls attention to the need for further development of novel and more efficient delivery systems. In order to address this issue, transferrin receptor (TfR)-targeted, protamine-containing lipid nanoparticles (Tf-LNs) were synthesized as delivery vehicles for G3139. The LNs were produced by an ethanol dilution method, and lipid-conjugated Tf ligand was then incorporated by a postinsertion method. The resulting Tf-LNs had a mean particle diameter of 90 nm and G3139 loading efficiency of 90.4%. Antisense delivery efficiency of Tf-LNs was evaluated in K562, MV4-11, and Raji leukemia cell lines. The results showed that Tf-LNs were more effective than nontargeted LNs and free G3139 (p < 0.05) in decreasing Bcl-2 expression (by up to 62% at the mRNA level in K562 cells) and in inducing caspase-dependent apoptosis. In addition, Bcl-2 down-regulation and apoptosis induced by Tf-LN G3139 were shown to be blocked by excess free Tf and thus were TfR-dependent. Cell lines with higher TfR expression also showed greater Bcl-2 down-regulation. Furthermore, up-regulation of TfR expression in leukemia cells by iron chelator deferoxamine resulted in a further increase in antisense effect (up to 79% Bcl-2 reduction in K562 at the mRNA level) and in caspase-dependent apoptosis (by 3-fold) by Tf-LN. Tf-LN-mediated delivery combined with TfR up-regulation by deferoxamine appears to be a potentially promising strategy for enhancing the delivery efficiency and therapeutic efficacy of antisense oligonucleotides. JF - Molecular Pharmaceutics AU - Yang, Xiaojuan AU - Koh, Chee Guan AU - Liu, Shujun AU - Pan, Xiaogang AU - Santhanam, Ramasamy AU - Yu, Bo AU - Peng, Yong AU - Pang, Jiuxia AU - Golan, Sharon AU - Talmon, Yeshayahu AU - Jin, Yan AU - Muthusamy, Natarajan AU - Byrd, John C AU - Chan, Kenneth K AU - Lee, L James AU - Marcucci, Guido AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, NSF Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), Department of Chemical and Biomolecular Engineering, NCI Comprehensive Cancer Center (CCC), Department of Molecular and Cellular Biochemistry, and Division of Hematology and Oncology, The Ohio State University, Columbus, Ohio 43210, and Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 221 EP - 230 PB - American Chemical Society VL - 6 IS - 1 SN - 1543-8384, 1543-8384 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Lipids KW - Chemoresistance KW - Chelating agents KW - Clinical trials KW - mRNA KW - Antisense oligonucleotides KW - Tumor cell lines KW - Transferrin KW - Transferrin receptors KW - Bcl-2 protein KW - Iron KW - nanoparticles KW - Deferoxamine KW - Ethanol KW - W 30915:Pharmaceuticals & Vaccines KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754549980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Transferrin+Receptor-Targeted+Lipid+Nanoparticles+for+Delivery+of+an+Antisense+Oligodeoxyribonucleotide+against+Bcl-2&rft.au=Yang%2C+Xiaojuan%3BKoh%2C+Chee+Guan%3BLiu%2C+Shujun%3BPan%2C+Xiaogang%3BSanthanam%2C+Ramasamy%3BYu%2C+Bo%3BPeng%2C+Yong%3BPang%2C+Jiuxia%3BGolan%2C+Sharon%3BTalmon%2C+Yeshayahu%3BJin%2C+Yan%3BMuthusamy%2C+Natarajan%3BByrd%2C+John+C%3BChan%2C+Kenneth+K%3BLee%2C+L+James%3BMarcucci%2C+Guido%3BLee%2C+Robert+J&rft.aulast=Yang&rft.aufirst=Xiaojuan&rft.date=2008-12-15&rft.volume=6&rft.issue=1&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp800149s LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Apoptosis; Chemoresistance; Lipids; Chelating agents; Clinical trials; mRNA; Antisense oligonucleotides; Transferrin; Tumor cell lines; Transferrin receptors; Bcl-2 protein; nanoparticles; Iron; Deferoxamine; Ethanol DO - http://dx.doi.org/10.1021/mp800149s ER - TY - JOUR T1 - 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. AN - 69894588; 18785202 AB - 15-LOX-1 and its metabolites are involved in colorectal cancer. Recently, we reported that 15-LOX-1 overexpression in HCT-116 human colorectal cancer cells inhibited cell growth by induction of p53 phosphorylation (4). To determine whether the 15-LOX-1 protein or its metabolites are responsible for phosphorylation of p53 in HCT-116 cells, we used HCT-116 cells that expressed a mutant 15-LOX-1. The mutant 15-LOX-1 enzyme, with a substitution of Leu at residue His361, was devoid of enzymatic activity. HCT-116 cells transiently transfected with either native or mutant 15-LOX-1 showed an increase in p53 phosphorylation and an increase in the expression of downstream genes. Thus, 15-LOX-1 induces p53 phosphorylation independent of enzymatic activity. Treatment of A549 human lung carcinoma cells with IL-4 increased the expression of 15-LOX-1 and also increased the expression of downstream targets of p53. This confirmed that the activation of p53 was also observed in wild-type cells expressing physiological 15-LOX-1. Immunoprecipitation experiments revealed that 15-LOX-1 interacts with, and binds to, DNA-dependent protein kinase (DNA-PK). The binding of 15-LOX-1 to DNA-PK caused an approximate 3.0-fold enhancement in kinase activity, resulting in increased p53 phosphorylation at Ser15. Knockdown of DNA-PK by small interfering RNA (siRNA) significantly reduced p53 phosphorylation. Furthermore, confocal microscopy demonstrated a colocalization of 15-LOX and DNA-PK in the cells. We propose that the 15-LOX-1 protein binds to DNA-PK, increasing its kinase activity and results in downstream activation of the tumor suppressor p53, thus revealing a new mechanism by which lipoxygenases (LOX) may influence the phenotype of tumor cells. (c) 2008 Wiley-Liss, Inc. JF - International journal of cancer AU - Zhu, Hong AU - Glasgow, Wayne AU - George, Margaret D AU - Chrysovergis, Kali AU - Olden, Kenneth AU - Roberts, John D AU - Eling, Thomas AD - Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 2741 EP - 2749 VL - 123 IS - 12 KW - RNA, Small Interfering KW - 0 KW - Tumor Suppressor Protein p53 KW - DNA KW - 9007-49-2 KW - Linoleic Acid KW - 9KJL21T0QJ KW - Arachidonate 15-Lipoxygenase KW - EC 1.13.11.33 KW - Protein Kinases KW - EC 2.7.- KW - Index Medicus KW - Phenotype KW - Gene Expression Regulation, Neoplastic KW - Blotting, Western KW - Phosphorylation KW - Linoleic Acid -- metabolism KW - Transfection KW - Humans KW - DNA -- metabolism KW - Protein Kinases -- genetics KW - Immunoprecipitation KW - HCT116 Cells KW - Fluorescent Antibody Technique KW - Lung Neoplasms -- enzymology KW - Arachidonate 15-Lipoxygenase -- metabolism KW - Colorectal Neoplasms -- metabolism KW - Colorectal Neoplasms -- enzymology KW - Tumor Suppressor Protein p53 -- metabolism KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69894588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=15-lipoxygenase-1+activates+tumor+suppressor+p53+independent+of+enzymatic+activity.&rft.au=Zhu%2C+Hong%3BGlasgow%2C+Wayne%3BGeorge%2C+Margaret+D%3BChrysovergis%2C+Kali%3BOlden%2C+Kenneth%3BRoberts%2C+John+D%3BEling%2C+Thomas&rft.aulast=Zhu&rft.aufirst=Hong&rft.date=2008-12-15&rft.volume=123&rft.issue=12&rft.spage=2741&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.23855 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prostaglandins Leukot Essent Fatty Acids. 2001 Apr-May;64(4-5):217-25 [11418015] J Biol Chem. 2002 Jul 26;277(30):27360-6 [12004065] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9968-73 [12909723] J Immunol. 2003 Jan 15;170(2):887-94 [12517954] J Biol Chem. 2004 Jul 9;279(28):29023-30 [15123652] Immunol Rev. 2004 Aug;200:132-41 [15242401] J Biol Chem. 1990 Mar 25;265(9):5113-20 [2318885] Mol Cell Biol. 1992 Nov;12(11):5041-9 [1406679] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6148-52 [9177185] Cell. 1997 Oct 31;91(3):325-34 [9363941] Int J Biochem Cell Biol. 1997 Jul;29(7):935-8 [9375373] Nat Struct Biol. 1997 Dec;4(12):1003-9 [9406550] Blood. 1998 Jan 1;91(1):64-74 [9414270] J Biol Chem. 1998 Aug 21;273(34):21569-77 [9705287] Science. 1998 Sep 11;281(5383):1677-9 [9733515] Cancer Res. 1998 Oct 1;58(19):4375-82 [9766667] Genes Dev. 1999 Jan 15;13(2):152-7 [9925639] Carcinogenesis. 1999 Oct;20(10):1985-95 [10506115] Biochemistry. 2004 Dec 7;43(48):15296-302 [15568822] Neoplasia. 2004 Nov-Dec;6(6):821-30 [15720809] Ann Surg. 2005 Jun;241(6):941-6; discussion 946-7 [15912043] Mol Cancer Res. 2005 Sep;3(9):511-7 [16179498] J Biol Chem. 2006 Jan 13;281(2):1196-204 [16251187] Oncogene. 2006 Feb 23;25(8):1225-41 [16288226] Neoplasia. 2006 Jun;8(6):510-22 [16820097] Nat Rev Cancer. 2006 Dec;6(12):909-23 [17128209] Biochim Biophys Acta. 2006 Dec;1761(12):1498-505 [17052953] Exp Cell Res. 2006 Dec 10;312(20):4056-69 [17056038] Curr Drug Metab. 2006 Dec;7(8):853-72 [17168687] J Gastroenterol Hepatol. 2007 Dec;22(12):2324-9 [17559385] Biochemistry. 2000 Mar 28;39(12):3185-91 [10727209] Int J Cancer. 2000 Jul 1;87(1):37-43 [10861450] J Natl Cancer Inst. 2000 Jul 19;92(14):1136-42 [10904086] J Biol Chem. 2001 May 11;276(19):16520-7 [11297527] Science. 2001 Jun 15;292(5524):2083-6 [11408659] Prostaglandins Leukot Essent Fatty Acids. 2004 Jan;70(1):7-15 [14643174] J Biol Chem. 2004 Jan 30;279(5):3717-25 [14594811] Methods Mol Biol. 2004;284:1-14 [15173605] Carcinogenesis. 2001 Nov;22(11):1765-73 [11698337] Curr Urol Rep. 2002 Jun;3(3):207-14 [12084190] Carcinogenesis. 2003 Feb;24(2):243-7 [12584173] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.23855 ER - TY - JOUR T1 - Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus). AN - 69870302; 18848574 AB - Alkaloid profiles in skin of poison frogs/toads (Dendrobatidae, Mantellidae, Bufonidae, and Myobatrachidae) are highly dependent on diet and hence on the nature of habitat. Extracts of the two species of toads (Melanophryniscus klappenbachi and Melanophryniscus cupreuscapularis) from similar habitats in the Corrientes/Chaco Provinces of Argentina have similar profiles of alkaloids, which differ considerably in profiles from other Melanophryniscus species from Brazil, Uruguay and Argentina. Structures of two major alkaloids 239Q (1) and 275I (2) were determined by mass, FTIR, and NMR spectral analysis as 5Z,9Z-3-(1-hydroxybutyl)-5-propylindolizidine and 6Z,10E-4,6-di(pent-4-enyl) quinolizidine, respectively. A third alkaloid, 249F (3), is postulated to be a homopumiliotoxin with an unprecedented conjugated exocyclic diene moiety. JF - Toxicon : official journal of the International Society on Toxinology AU - Daly, John W AU - Garraffo, H Martin AU - Spande, Thomas F AU - Yeh, Herman J C AU - Peltzer, Paola M AU - Cacivio, Pedro M AU - Baldo, J Diego AU - Faivovich, Julián AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 858 EP - 870 VL - 52 IS - 8 SN - 0041-0101, 0041-0101 KW - Alkaloids KW - 0 KW - Indolizidines KW - Quinolizidines KW - Index Medicus KW - Molecular Structure KW - Gastrointestinal Contents -- chemistry KW - Spectroscopy, Fourier Transform Infrared KW - Animals KW - Alkaloids -- chemistry KW - Argentina KW - Nuclear Magnetic Resonance, Biomolecular KW - Gas Chromatography-Mass Spectrometry KW - Alkaloids -- isolation & purification KW - Alkaloids -- analysis KW - Indolizidines -- chemistry KW - Skin -- chemistry KW - Bufonidae -- metabolism KW - Quinolizidines -- chemistry KW - Quinolizidines -- analysis KW - Indolizidines -- isolation & purification KW - Indolizidines -- analysis KW - Quinolizidines -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69870302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Indolizidine+239Q+and+quinolizidine+275I.+Major+alkaloids+in+two+Argentinian+bufonid+toads+%28Melanophryniscus%29.&rft.au=Daly%2C+John+W%3BGarraffo%2C+H+Martin%3BSpande%2C+Thomas+F%3BYeh%2C+Herman+J+C%3BPeltzer%2C+Paola+M%3BCacivio%2C+Pedro+M%3BBaldo%2C+J+Diego%3BFaivovich%2C+Juli%C3%A1n&rft.aulast=Daly&rft.aufirst=John&rft.date=2008-12-15&rft.volume=52&rft.issue=8&rft.spage=858&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2008.08.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-12 N1 - Date created - 2008-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicon. 2005 Nov;46(6):641-50 [16157358] J Nat Prod. 2005 Oct;68(10):1556-75 [16252926] J Chem Ecol. 2006 Apr;32(4):795-814 [16718571] Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jan;144(4):398-402 [17208052] J Nat Prod. 2007 Feb;70(2):160-8 [17243727] J Chem Ecol. 2007 Apr;33(4):871-87 [17333373] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8885-90 [17502597] Toxicon. 2007 Nov;50(6):757-78 [17706737] Toxicon. 1978;16(2):163-88 [635931] J Nat Prod. 2002 Apr;65(4):439-47 [11975476] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13996-4001 [12381780] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11092-7 [12960405] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12792-7 [14555763] Mol Phylogenet Evol. 2004 May;31(2):462-75 [15062788] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4346-51 [15070720] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8045-50 [15128938] J Nat Prod. 2004 Aug;67(8):1211-5 [15332834] Science. 1967 May 19;156(3777):970-3 [6023266] Syst Zool. 1967 Dec;16(4):328-42 [6064273] J Am Chem Soc. 1969 Jul 2;91(14):3931-8 [5814950] Experientia. 1971 May 15;27(5):506 [5132572] J Chem Ecol. 2005 Oct;31(10):2403-15 [16195851] Am Nat. 2005 Jan;165(1):56-69 [15729640] Toxicon. 2004 Dec 15;44(8):805-15 [15530960] Science. 1975 Jul 11;189(4197):151-2 [1138374] J Morphol. 1998 Jul;237(1):19-32 [9642789] Toxicon. 1997 May;35(5):705-9 [9203295] Toxicon. 1995 Feb;33(2):246-9 [7597728] Toxicon. 1994 Mar;32(3):279-85 [8016850] J Nat Prod. 1993 Mar;56(3):357-73 [8482947] Steroids. 1986 Sep-Oct;48(3-4):251-7 [3127947] Chem Pharm Bull (Tokyo). 1986 Aug;34(8):3454-7 [3791519] Toxicon. 1984;22(6):905-19 [6523513] Chem Pharm Bull (Tokyo). 1980 May;28(5):1559-62 [7408047] Science. 1980 May 2;208(4443):503-5 [6245447] Nat Prod Rep. 1998 Aug;15(4):397-413 [9736996] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxicon.2008.08.016 ER - TY - JOUR T1 - A validated gas chromatographic-electron impact ionization mass spectrometric method for methamphetamine, methylenedioxymethamphetamine (MDMA), and metabolites in mouse plasma and brain. AN - 69845804; 19026602 AB - A method was developed and fully validated for simultaneous quantification of methamphetamine (MAMP), amphetamine, hydroxy-methamphetamine, methylenedioxymethamphetamine (MDMA, ecstasy), methylenedioxyamphetamine, 3-hydroxy-4-methoxy-methamphetamine, and 3-hydroxy-4-methoxy-amphetamine in 100 microL mouse plasma and 7.5mg brain. Solid phase extraction and gas chromatography-electron impact ionization mass spectrometry in selected-ion monitoring mode achieved plasma linear ranges of 10-20 to 20,000 ng/mL and 0.1-0.2 to 200 ng/mg in brain. Recoveries were greater than 91%, bias 92.3-110.4%, and imprecision less than 5.3% coefficient of variation. This method was used for measuring MAMP and MDMA and metabolites in plasma and brain during mouse neurotoxicity studies. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Scheidweiler, Karl B AU - Barnes, Allan J AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 266 EP - 276 VL - 876 IS - 2 SN - 1570-0232, 1570-0232 KW - Methamphetamine KW - 44RAL3456C KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Humans KW - Brain Chemistry KW - Mice KW - Hydrolysis KW - Male KW - Spectrometry, Mass, Electrospray Ionization -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - N-Methyl-3,4-methylenedioxyamphetamine -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- blood KW - Methamphetamine -- blood KW - Methamphetamine -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- analysis KW - Methamphetamine -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69845804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=A+validated+gas+chromatographic-electron+impact+ionization+mass+spectrometric+method+for+methamphetamine%2C+methylenedioxymethamphetamine+%28MDMA%29%2C+and+metabolites+in+mouse+plasma+and+brain.&rft.au=Scheidweiler%2C+Karl+B%3BBarnes%2C+Allan+J%3BHuestis%2C+Marilyn+A&rft.aulast=Scheidweiler&rft.aufirst=Karl&rft.date=2008-12-15&rft.volume=876&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/10.1016%2Fj.jchromb.2008.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 1997 Dec;19(6):1285-96 [9427251] J Pharmacol Exp Ther. 1998 Mar;284(3):1040-7 [9495865] Mol Pharmacol. 1998 Apr;53(4):649-55 [9547354] J Chromatogr B Biomed Sci Appl. 1999 Feb 19;723(1-2):221-32 [10080649] Br J Pharmacol. 2005 Jan;144(2):231-41 [15665862] Clin Chem. 2005 Oct;51(10):1811-22 [16099938] Ann N Y Acad Sci. 2000 Sep;914:104-11 [11085313] J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 17;832(1):81-9 [16436334] J Psychopharmacol. 2006 May;20(3):456-63 [16574720] Xenobiotica. 2006 Feb-Mar;36(2-3):259-67 [16702115] AAPS J. 2006;8(2):E337-47 [16796384] J Neurochem. 2006 Jul;98(2):495-505 [16749908] Psychopharmacology (Berl). 2007 Jan;189(4):407-24 [16541247] J Anal Toxicol. 2006 Oct;30(8):563-9 [17132253] Annu Rev Pharmacol Toxicol. 2007;47:681-98 [17209801] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] J Anal Toxicol. 2007 Apr;31(3):138-43 [17579960] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):262-70 [17646137] Biol Psychiatry. 2007 Sep 15;62(6):669-79 [17306775] Biomed Chromatogr. 2007 Oct;21(10):1016-22 [17474141] Clin Chem. 2008 Feb;54(2):379-87 [18089653] Xenobiotica. 2008 Mar;38(3):314-24 [18274959] J Pharm Sci. 2008 Apr;97(4):1593-605 [17724664] Drug Alcohol Rev. 2008 May;27(3):236-42 [18368604] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):78-83 [18396472] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 15;874(1-2):119-24 [18829400] J Neurosci. 1999 Nov 15;19(22):10107-15 [10559418] J Pharm Biomed Anal. 1999 Dec;21(4):739-47 [10701939] Neurology. 2000 Mar 28;54(6):1344-9 [10746608] Mol Pharmacol. 2000 Dec;58(6):1247-56 [11093760] Neuroscience. 2001;107(2):265-74 [11731100] Drug Alcohol Depend. 2002 Apr 1;66(2):147-59 [11906802] J Anal Toxicol. 2002 Apr;26(3):157-65 [11991532] Neurosci Res. 2002 Jul;43(3):251-7 [12103443] Clin Chem. 2002 Sep;48(9):1472-85 [12194924] Rapid Commun Mass Spectrom. 2003;17(4):330-6 [12569443] J Anal Toxicol. 2003 Mar;27(2):78-87 [12670001] Brain Res Brain Res Rev. 2003 May;42(2):155-68 [12738056] J Mass Spectrom. 2003 Jun;38(6):659-76 [12827635] J Neurochem. 2003 Jul;86(2):413-21 [12871582] Pharmacol Rev. 2003 Sep;55(3):463-508 [12869661] FASEB J. 2003 Oct;17(13):1775-88 [14519657] Biomed Chromatogr. 2003 Oct;17(7):471-6 [14598332] J Anal Toxicol. 2003 Nov-Dec;27(8):552-9 [14670133] J Neurosci. 2004 Mar 3;24(9):2212-25 [14999072] Psychopharmacology (Berl). 2004 May;173(3-4):310-7 [14747902] Psychopharmacology (Berl). 2004 May;173(3-4):249-63 [15083264] Biol Mass Spectrom. 1993 Jul;22(7):403-11 [8102882] J Chromatogr B Biomed Appl. 1995 Feb 17;664(2):449-57 [7780602] J Anal Toxicol. 1996 Oct;20(6):432-40 [8889680] J Neurochem. 1997 Aug;69(2):780-90 [9231739] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jchromb.2008.11.001 ER - TY - JOUR T1 - Age, sex, and race influence single-strand break repair capacity in a human population. AN - 69843217; 18845243 AB - Recently, we developed an improved comet assay protocol for evaluating single-strand break repair capacity (SSB-RC) in unstimulated cryopreserved human peripheral blood mononuclear cells (PBMCs). This methodology facilitates control of interexperimental variability [A.R. Trzeciak, J. Barnes, M.K. Evans, A modified alkaline comet assay for measuring DNA repair capacity in human populations. Radiat. Res. 169 (2008) 110-121]. The fast component of SSB repair (F-SSB-RC) was assessed using a novel parameter, the initial rate of DNA repair, and the widely used half-time of DNA repair. The slow component of SSB repair (S-SSB-RC) was estimated using the residual DNA damage after 60 min. We have examined repair of gamma-radiation-induced DNA damage in PBMCs from four age-matched groups of male and female whites and African-Americans between ages 30 and 64. There is an increase in F-SSB-RC with age in white females (P<0.01) and nonsignificant decrease in F-SSB-RC in African-American females (P=0.061). F-SSB-RC is lower in white females than in white males (P<0.01). There is a decrease in F-SSB-RC with age in African-American females as compared to white females (P<0.002) and African-American males (nonsignificant, P=0.059). Age, sex, and race had a similar effect on intercellular variability of DNA damage in gamma-irradiated and repairing PBMCs. Our findings suggest that age, sex, and race influence SSB-RC as measured by the alkaline comet assay. SSB-RC may be a useful clinical biomarker. JF - Free radical biology & medicine AU - Trzeciak, Andrzej R AU - Barnes, Janice AU - Ejiogu, Ngozi AU - Foster, Kamala AU - Brant, Larry J AU - Zonderman, Alan B AU - Evans, Michele K AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 1631 EP - 1641 VL - 45 IS - 12 SN - 0891-5849, 0891-5849 KW - DNA, Single-Stranded KW - 0 KW - Index Medicus KW - Age Factors KW - Leukocytes, Mononuclear -- radiation effects KW - Sex Factors KW - Gamma Rays KW - Humans KW - African Americans KW - Comet Assay -- methods KW - European Continental Ancestry Group KW - Adult KW - Leukocytes, Mononuclear -- metabolism KW - Middle Aged KW - Female KW - Male KW - Continental Population Groups -- genetics KW - DNA, Single-Stranded -- genetics KW - DNA Repair KW - DNA, Single-Stranded -- analysis KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69843217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Age%2C+sex%2C+and+race+influence+single-strand+break+repair+capacity+in+a+human+population.&rft.au=Trzeciak%2C+Andrzej+R%3BBarnes%2C+Janice%3BEjiogu%2C+Ngozi%3BFoster%2C+Kamala%3BBrant%2C+Larry+J%3BZonderman%2C+Alan+B%3BEvans%2C+Michele+K&rft.aulast=Trzeciak&rft.aufirst=Andrzej&rft.date=2008-12-15&rft.volume=45&rft.issue=12&rft.spage=1631&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.08.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-23 N1 - Date created - 2008-11-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mutagenesis. 2006 May;21(3):173-8 [16613912] Environ Mol Mutagen. 2006 May;47(4):260-70 [16470524] Mutat Res. 2006 Jun 16;605(1-2):7-16 [16621680] Biochem Biophys Res Commun. 2006 Jun 30;345(2):726-33 [16696946] Environ Res. 2006 Oct;102(2):181-96 [16828737] DNA Repair (Amst). 2007 Jan 4;6(1):45-60 [16982217] Nat Protoc. 2007;2(5):1084-104 [17546000] Age Ageing. 2007 Sep;36(5):521-6 [17913757] Radiat Res. 2008 Jan;169(1):110-21 [18159959] Radiat Environ Biophys. 2001 Mar;40(1):83-9 [11357715] Nucleic Acids Res. 2002 Jan 15;30(2):E1 [11788727] Cancer Res. 2002 May 15;62(10):2791-7 [12019155] Br J Radiol. 2002 Jul;75(895):608-14 [12145135] Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(5):1216-25 [12654430] Acta Biochim Pol. 2003;50(1):181-90 [12673358] Carcinogenesis. 2003 May;24(5):883-9 [12771032] Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):689-98 [12917198] Mutat Res. 2003 Nov 10;541(1-2):1-8 [14568289] Cytogenet Genome Res. 2004;104(1-4):14-20 [15162010] Radiat Environ Biophys. 1983;22(1):3-19 [6611843] Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Nov;50(5):893-908 [3490451] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Radiat Res. 1988 Dec;116(3):511-25 [3060896] Radiat Res. 1990 Apr;122(1):86-94 [2320728] Mutat Res. 1990 May-Jul;237(3-4):123-30 [2233818] Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1614-8 [8434025] Mutat Res. 1993 Oct;294(3):275-83 [7692267] J Invest Dermatol. 1997 Feb;108(2):154-9 [9008227] Mutat Res. 1997 Jan 31;383(1):71-80 [9042421] Mutat Res. 1997 Mar 21;374(2):261-8 [9100849] Mutat Res. 1997 Jun;386(3):315-34 [9219569] Mutat Res. 1998 Mar 16;413(2):111-9 [9639687] Int J Radiat Biol. 1998 Jun;73(6):649-60 [9690683] J Biol Chem. 1998 Sep 18;273(38):24822-31 [9733786] Environ Mol Mutagen. 2000;35(3):206-21 [10737956] Mutat Res. 2000 Sep 20;469(2):181-97 [10984679] Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S77-91 [11041079] J Natl Cancer Inst. 2000 Nov 1;92(21):1764-72 [11058619] Int J Cancer. 2001 Mar 20;95(2):86-91 [11241317] FASEB J. 1998 Oct;12(13):1397-400 [9761783] Radiat Res. 1998 Nov;150(5 Suppl):S42-51 [9806608] Mutagenesis. 2006 May;21(3):205-11 [16613913] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.08.031 ER - TY - JOUR T1 - Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. AN - 69839286; 18782848 AB - The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, the genetic deficiency of the glycogen-degrading lysosomal enzyme acid-alpha glucosidase. Accumulation of lysosomal glycogen, presumably transported from the cytoplasm by the autophagic pathway, occurs in multiple tissues, but pathology is most severe in skeletal and cardiac muscle. Skeletal muscle pathology also involves massive autophagic buildup in the core of myofibers. To determine if glycogen reaches the lysosome via autophagy and to ascertain whether autophagic buildup in Pompe disease is a consequence of induction of autophagy and/or reduced turnover due to defective fusion with lysosomes, we generated muscle-specific autophagy-deficient Pompe mice. We have demonstrated that autophagy is not required for glycogen transport to lysosomes in skeletal muscle. We have also found that Pompe disease involves induction of autophagy but manifests as a functional deficiency of autophagy because of impaired autophagosomal-lysosomal fusion. As a result, autophagic substrates, including potentially toxic aggregate-prone ubiquitinated proteins, accumulate in Pompe myofibers and may cause profound muscle damage. JF - Human molecular genetics AU - Raben, Nina AU - Hill, Victoria AU - Shea, Lauren AU - Takikita, Shoichi AU - Baum, Rebecca AU - Mizushima, Noboru AU - Ralston, Evelyn AU - Plotz, Paul AD - Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA. rabenn@arb.niams.nih.gov Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 3897 EP - 3908 VL - 17 IS - 24 KW - Proteins KW - 0 KW - alpha-Glucosidases KW - EC 3.2.1.20 KW - Index Medicus KW - Animals KW - Mice KW - alpha-Glucosidases -- deficiency KW - Mice, Transgenic KW - alpha-Glucosidases -- genetics KW - Male KW - Female KW - Mice, Knockout KW - Autophagy -- genetics KW - Muscle, Skeletal -- pathology KW - Muscular Diseases -- pathology KW - Ubiquitination -- genetics KW - Glycogen Storage Disease Type II -- genetics KW - Muscle, Skeletal -- enzymology KW - Proteins -- metabolism KW - Proteins -- genetics KW - Muscular Diseases -- metabolism KW - Glycogen Storage Disease Type II -- enzymology KW - Muscular Diseases -- etiology KW - Proteins -- adverse effects KW - Glycogen Storage Disease Type II -- pathology KW - Muscle, Skeletal -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Suppression+of+autophagy+in+skeletal+muscle+uncovers+the+accumulation+of+ubiquitinated+proteins+and+their+potential+role+in+muscle+damage+in+Pompe+disease.&rft.au=Raben%2C+Nina%3BHill%2C+Victoria%3BShea%2C+Lauren%3BTakikita%2C+Shoichi%3BBaum%2C+Rebecca%3BMizushima%2C+Noboru%3BRalston%2C+Evelyn%3BPlotz%2C+Paul&rft.aulast=Raben&rft.aufirst=Nina&rft.date=2008-12-15&rft.volume=17&rft.issue=24&rft.spage=3897&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=1460-2083&rft_id=info:doi/10.1093%2Fhmg%2Fddn292 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2008-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Mol Genet. 2008 Jan 1;17(1):119-29 [17913701] Cell. 2007 Dec 14;131(6):1149-63 [18083104] Nature. 2008 Feb 28;451(7182):1069-75 [18305538] Traffic. 2008 Apr;9(4):574-87 [18182013] Autophagy. 2008 May;4(4):524-6 [18367868] Autophagy. 2008 Jul;4(5):727-30 [18437051] J Biol Chem. 2008 Aug 15;283(33):22847-57 [18524774] J Pathol. 1999 Nov;189(3):416-24 [10547605] EMBO J. 2000 Nov 1;19(21):5720-8 [11060023] J Cell Biol. 2001 Feb 19;152(4):657-68 [11266458] Science. 2001 Nov 23;294(5547):1704-8 [11679633] Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14440-5 [11717410] Curr Opin Neurol. 2002 Oct;15(5):525-31 [12351995] FASEB J. 2002 Nov;16(13):1697-712 [12409312] Curr Neurol Neurosci Rep. 2003 Jan;3(1):64-9 [12507414] Cell Struct Funct. 2002 Dec;27(6):421-9 [12576635] Biochim Biophys Acta. 2003 Mar 20;1637(2):164-70 [12633905] Biochem Biophys Res Commun. 2004 Jan 9;313(2):453-8 [14684184] FASEB J. 2004 Jan;18(1):39-51 [14718385] Microsc Res Tech. 2004 Feb 1;63(2):87-93 [14722905] Oncogene. 2004 Mar 15;23(11):2057-70 [15021893] Dev Cell. 2004 Apr;6(4):463-77 [15068787] Cell. 2004 Apr 30;117(3):399-412 [15109499] Microsc Res Tech. 2004 May 1;64(1):10-20 [15287014] Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18 [15325588] J Cell Biol. 1972 Jan;52(1):41-51 [4331300] Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(1):23-36 [6199885] J Morphol. 1994 Aug;221(2):177-90 [7932768] J Biol Chem. 1998 Jul 24;273(30):19086-92 [9668092] Nucleic Acids Res. 1999 Oct 1;27(19):e27 [10481039] Biochim Biophys Acta. 2004 Nov 29;1695(1-3):89-111 [15571811] Mol Ther. 2005 Jan;11(1):48-56 [15585405] J Cell Sci. 2005 Jan 1;118(Pt 1):7-18 [15615779] Nature. 2004 Dec 23;432(7020):1032-6 [15525940] J Biomech. 2005 May;38(5):1035-43 [15797585] J Cell Biol. 2005 May 9;169(3):425-34 [15866887] Histol Histopathol. 2005 Jul;20(3):689-96 [15944916] J Neuropathol Exp Neurol. 2005 Jun;64(6):513-22 [15977643] J Cell Biol. 2005 Nov 21;171(4):603-14 [16286508] Am J Pathol. 2005 Dec;167(6):1713-28 [16314482] Traffic. 2006 Feb;7(2):129-45 [16420522] Ann Neurol. 2006 Apr;59(4):700-8 [16532490] Nature. 2006 Jun 15;441(7095):885-9 [16625204] Nature. 2006 Jun 15;441(7095):880-4 [16625205] J Pediatr. 2006 Jul;149(1):89-97 [16860134] Pathol Res Pract. 2006;202(9):631-8 [16781826] Autophagy. 2006 Oct-Dec;2(4):318-20 [16874053] J Biol Chem. 2006 Nov 24;281(47):36303-16 [16963441] Lab Invest. 2006 Dec;86(12):1208-20 [17075580] Mol Ther. 2006 Dec;14(6):831-9 [17008131] Curr Neurol Neurosci Rep. 2007 Jan;7(1):71-7 [17217857] Autophagy. 2007 May-Jun;3(3):259-62 [17329960] Hum Mol Genet. 2007 Apr 15;16(8):919-28 [17329348] Mol Genet Metab. 2007 Aug;91(4):343-51 [17572127] J Biol Chem. 2007 Aug 17;282(33):24131-45 [17580304] Mol Biol Cell. 2007 Oct;18(10):3952-65 [17686993] Autophagy. 2007 Nov-Dec;3(6):546-52 [17592248] Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7 [17712358] Autophagy. 2008 Feb;4(2):151-75 [18188003] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/hmg/ddn292 ER - TY - JOUR T1 - Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir. AN - 69820643; 18991509 AB - We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections. This case highlights the potential of ritonavir interactions even with local injections of a corticosteroid. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Ramanathan, Roshan AU - Pau, Alice K AU - Busse, Kristin H AU - Zemskova, Marina AU - Nieman, Lynnette AU - Kwan, Richard AU - Hammer, Jean H AU - Mican, JoAnn M AU - Maldarelli, Frank AD - Clinical Parasitology Unit and Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ramanathanr@niaid.nih.gov Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - e97 EP - e99 VL - 47 IS - 12 KW - Pyrimidinones KW - 0 KW - Triamcinolone KW - 1ZK20VI6TY KW - Lopinavir KW - 2494G1JF75 KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - Drug Interactions KW - HIV-1 -- isolation & purification KW - Humans KW - Adult KW - Male KW - Ritonavir -- therapeutic use KW - Triamcinolone -- adverse effects KW - Iatrogenic Disease KW - HIV Infections -- complications KW - Triamcinolone -- administration & dosage KW - HIV Infections -- drug therapy KW - Pyrimidinones -- therapeutic use KW - Cushing Syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69820643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Iatrogenic+Cushing+syndrome+after+epidural+triamcinolone+injections+in+an+HIV+type+1-infected+patient+receiving+therapy+with+ritonavir-lopinavir.&rft.au=Ramanathan%2C+Roshan%3BPau%2C+Alice+K%3BBusse%2C+Kristin+H%3BZemskova%2C+Marina%3BNieman%2C+Lynnette%3BKwan%2C+Richard%3BHammer%2C+Jean+H%3BMican%2C+JoAnn+M%3BMaldarelli%2C+Frank&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-15&rft.volume=47&rft.issue=12&rft.spage=e97&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F593314 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharm Pharmacol. 2003 Mar;55(3):381-6 [12724045] Clin Exp Immunol. 1976 Apr;24(1):54-62 [1084818] Clin Pharmacol Ther. 1986 Mar;39(3):313-7 [3948470] J Clin Pharmacol. 1994 Aug;34(8):854-8 [7962675] Clin Biochem. 2005 Jun;38(6):531-4 [15885232] AIDS Read. 2008 Feb;18(2):100-4 [18333287] J Clin Endocrinol Metab. 2005 Jul;90(7):4394-8 [15755851] J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):573-80 [16284534] Endocr Pract. 2005 Nov-Dec;11(6):408-10 [16638729] Ther Drug Monit. 2007 Dec;29(6):687-710 [18043468] Drug Metab Dispos. 2005 Jun;33(6):764-70 [15764714] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/593314 ER - TY - JOUR T1 - SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap AN - 20274009; 8920964 AB - Summary: The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies).Availability: SNAP server is available at http://www.broad.mit.edu/mpg/snap/.Contact: debakkerroad.mit.edu JF - Bioinformatics AU - Johnson, Andrew D AU - Handsaker, Robert E AU - Pulit, Sara L AU - Nizzari, Marcia M AU - O'Donnell, Christopher J AU - de Bakker, Paul IW AD - 1 The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health and Boston University School of Medicine, Framingham, MA 01702, 2 Broad Institute of MIT and Harvard, Cambridge, MA 02142, 3 Division of Genetics, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School-Partners HealthCare Center for Genetics and Genomics, 77 Avenue Louis Pasteur, Boston, MA 02215 and 4 Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 2938 EP - 2939 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 24 IS - 24 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Linkage disequilibrium KW - Data processing KW - Single-nucleotide polymorphism KW - Computer graphics KW - Bioinformatics KW - genomics KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20274009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SNAP%3A+a+web-based+tool+for+identification+and+annotation+of+proxy+SNPs+using+HapMap&rft.au=Johnson%2C+Andrew+D%3BHandsaker%2C+Robert+E%3BPulit%2C+Sara+L%3BNizzari%2C+Marcia+M%3BO%27Donnell%2C+Christopher+J%3Bde+Bakker%2C+Paul+IW&rft.aulast=Johnson&rft.aufirst=Andrew&rft.date=2008-12-15&rft.volume=24&rft.issue=24&rft.spage=2938&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn564 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Linkage disequilibrium; Data processing; Single-nucleotide polymorphism; Computer graphics; genomics; Bioinformatics DO - http://dx.doi.org/10.1093/bioinformatics/btn564 ER - TY - JOUR T1 - Polychlorinated dibenzo-p-dioxins/dibenzofuran mass distribution in both start-up and normal condition in the whole municipal solid waste incinerator AN - 19682334; 8615697 AB - Although many researches focused on the polychlorinated dibenzo-p-dioxins/dibenzofuran (PCDD/F) emissions from stack, in the bottom ash and in the surrounding environment, researches focused on PCDD/F mass distributions in the whole incineration plant have seldom been addressed. This study determined PCDD/F emissions in the whole plant. A high-resolution gas chromatograph /high-resolution mass spectrometer was utilized for analyzing 17 PCDD/F species. Experimental results displayed that PCDD/Fs were formed during fly ash from super heater (SH), economizer (EC), semi-dryer absorber (SDA) and fabric filter (FF) was transferred to fly ash pit. Mass distribution ratios of PCDD/Fs in g I-TEQ (Toxicity Equivalency Quantity) per week from stack, SH, EC, SDA, FF, generation and bottom residue (BR) in start-up operations were 14.6%, 0.1%, 8.3%, 1.0%, 41.7%, 33.4% and 0.9%, respectively. Above results indicated that main PCDD/F source in the MSWI was from fly ash. However, the fly ash is easily controlled and PCDD/F emitted from stack flue gases will be difficult to be handled. Therefore, we should pay more attention on PCDD/F emission from flue gases especially from start-up procedure. Besides, fly ash should be controlled by sodium hypophosphite before being landfilled. MSWI did require further detoxification treatments for the solid residues and flue gases. JF - Journal of Hazardous Materials AU - Chen, C K AU - Lin, C AU - Lin, Y C AU - Wang, L C AU - Chang-Chien, G P AD - National Pingtung University of Science and Technology, Nei Pu, Ping Tung 91207, Taiwan, linchieh@mail.npust.edu.tw Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 37 EP - 44 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 160 IS - 1 SN - 0304-3894, 0304-3894 KW - Pollution Abstracts; Toxicology Abstracts KW - Detoxification KW - Municipal solid wastes KW - Solid wastes KW - Incineration plants KW - Emissions KW - PCDD KW - Residues KW - Flue gas KW - Fly ash KW - Toxicity KW - Sodium KW - Filters KW - Fabrics KW - Gases KW - Dibenzofuran KW - Dibenzo-p-dioxin KW - Incinerators KW - P 0000:AIR POLLUTION KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19682334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Polychlorinated+dibenzo-p-dioxins%2Fdibenzofuran+mass+distribution+in+both+start-up+and+normal+condition+in+the+whole+municipal+solid+waste+incinerator&rft.au=Chen%2C+C+K%3BLin%2C+C%3BLin%2C+Y+C%3BWang%2C+L+C%3BChang-Chien%2C+G+P&rft.aulast=Chen&rft.aufirst=C&rft.date=2008-12-15&rft.volume=160&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2008.02.077 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fabrics; Filters; Detoxification; Sodium; Gases; Dibenzofuran; Dibenzo-p-dioxin; Incinerators; Fly ash; Toxicity; Solid wastes; Residues; Flue gas; Municipal solid wastes; Incineration plants; Emissions; PCDD DO - http://dx.doi.org/10.1016/j.jhazmat.2008.02.077 ER - TY - CPAPER T1 - Carbon Monoxide Blocks Lipopolysaccharide (LPS)-induced Gene Expression by Interfering with Proximal NF-B Signal Transduction in Human Monocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41913030; 5090089 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chhikara, M AU - Wang, S AU - Kern, S AU - Danner, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Carbon monoxide KW - Signal transduction KW - Gene expression KW - NF-B protein KW - Monocytes KW - Lipopolysaccharides KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Carbon+Monoxide+Blocks+Lipopolysaccharide+%28LPS%29-induced+Gene+Expression+by+Interfering+with+Proximal+NF-B+Signal+Transduction+in+Human+Monocytes.&rft.au=Chhikara%2C+M%3BWang%2C+S%3BKern%2C+S%3BDanner%2C+R&rft.aulast=Chhikara&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Receptor Possessing Chaperone Activity: The Sigma-1 Receptor at the Mitochondrion-associated ER Membrane. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41911458; 5090329 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Hayashi, T AU - Su, T. Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membranes KW - Chaperones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Receptor+Possessing+Chaperone+Activity%3A+The+Sigma-1+Receptor+at+the+Mitochondrion-associated+ER+Membrane.&rft.au=Hayashi%2C+T%3BSu%2C+T.&rft.aulast=Hayashi&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Metabolism and Signaling in Mouse Embryonic Fibroblasts Derived from an O-GlcNAcase (OGA) Knockout. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41910275; 5090590 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Keembiyehetty, C AU - Comly, M AU - Love, D AU - Robinson, G AU - Hennighausen, L AU - Hanover, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Metabolism KW - Signal transduction KW - Embryo fibroblasts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41910275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Altered+Metabolism+and+Signaling+in+Mouse+Embryonic+Fibroblasts+Derived+from+an+O-GlcNAcase+%28OGA%29+Knockout.&rft.au=Keembiyehetty%2C+C%3BComly%2C+M%3BLove%2C+D%3BRobinson%2C+G%3BHennighausen%2C+L%3BHanover%2C+J&rft.aulast=Keembiyehetty&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drosophila Myosin 7a Is Regulated by Intramolecular Folding. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41907049; 5090878 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Yang, Y AU - Baboolal, T AU - Siththanandan, V AU - Knight, P AU - Peckham, M AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41907049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Drosophila+Myosin+7a+Is+Regulated+by+Intramolecular+Folding.&rft.au=Yang%2C+Y%3BBaboolal%2C+T%3BSiththanandan%2C+V%3BKnight%2C+P%3BPeckham%2C+M%3BSellers%2C+J&rft.aulast=Yang&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of Cadherin 23 Alternate Transcripts and Protein Isoforms in the Mouse and Primate Inner Ear and Retina. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41902761; 5088757 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lagziel, A AU - Overlack, N AU - Wolfrum, U AU - Bernstein, S AU - Morell, R AU - Friedman, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Primates KW - Retina KW - Cadherin 23 KW - Inner ear KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Expression+of+Cadherin+23+Alternate+Transcripts+and+Protein+Isoforms+in+the+Mouse+and+Primate+Inner+Ear+and+Retina.&rft.au=Lagziel%2C+A%3BOverlack%2C+N%3BWolfrum%2C+U%3BBernstein%2C+S%3BMorell%2C+R%3BFriedman%2C+T&rft.aulast=Lagziel&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - One-Dimensional Topography Underlies Rapid Three-Dimensional Cell Migration. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41900455; 5090433 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Doyle, A AU - Wang, F AU - Matsumoto, K AU - Yamada, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Topography KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=One-Dimensional+Topography+Underlies+Rapid+Three-Dimensional+Cell+Migration.&rft.au=Doyle%2C+A%3BWang%2C+F%3BMatsumoto%2C+K%3BYamada%2C+K&rft.aulast=Doyle&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Is Tubulin Glutamylation Good For? An Analysis of Glutamylase Function in C. elegans. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41900281; 5090401 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Peel, N AU - O'Connell, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Tubulin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=What+Is+Tubulin+Glutamylation+Good+For%3F+An+Analysis+of+Glutamylase+Function+in+C.+elegans.&rft.au=Peel%2C+N%3BO%27Connell%2C+K&rft.aulast=Peel&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Hepatocyte Growth Factor Antagonist Engineered by Site-directed Mutagenesis of HGF/NK1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41899411; 5089086 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Cecchi, F AU - Pajalunga, D AU - Fowler, C AU - Peruzzi, B AU - MacDonald, N AU - Grella, D AU - Wingfield, P AU - Stahl, S AU - Kaufman, J AU - Byrd, A AU - Bottaro, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Growth factors KW - Hepatocyte growth factor KW - Site-directed mutagenesis KW - Mutagenesis KW - Hepatocytes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Hepatocyte+Growth+Factor+Antagonist+Engineered+by+Site-directed+Mutagenesis+of+HGF%2FNK1.&rft.au=Cecchi%2C+F%3BPajalunga%2C+D%3BFowler%2C+C%3BPeruzzi%2C+B%3BMacDonald%2C+N%3BGrella%2C+D%3BWingfield%2C+P%3BStahl%2C+S%3BKaufman%2C+J%3BByrd%2C+A%3BBottaro%2C+D&rft.aulast=Cecchi&rft.aufirst=Sreeparna&rft.date=2009-01-01&rft.volume=51&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health&rft.issn=13419145&rft_id=info:doi/10.1539%2Fjoh.L9070 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule Investigation of the Acto-Myosin-10 Complex Using Optical Tweezers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898945; 5088962 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Takagi, Y AU - Farrow, R AU - Mashanov, G AU - Batters, C AU - Yang, Y AU - Peckham, M AU - Sellers, J AU - Molloy, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Single+Molecule+Investigation+of+the+Acto-Myosin-10+Complex+Using+Optical+Tweezers.&rft.au=Takagi%2C+Y%3BFarrow%2C+R%3BMashanov%2C+G%3BBatters%2C+C%3BYang%2C+Y%3BPeckham%2C+M%3BSellers%2C+J%3BMolloy%2C+J&rft.aulast=Takagi&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin-X Is Required for Proper Behavior of Neural Crest Cells in Xenopus laevis T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898903; 5088961 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Hwang, Y AU - Luo, T AU - Xu, Y. AU - Sargent, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Neural crest KW - Amphibiotic species KW - Xenopus laevis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin-X+Is+Required+for+Proper+Behavior+of+Neural+Crest+Cells+in+Xenopus+laevis&rft.au=Hwang%2C+Y%3BLuo%2C+T%3BXu%2C+Y.%3BSargent%2C+T&rft.aulast=Hwang&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynein Light Chain LC8 Regulates Syntaphilin-mediated Docking of Axonal Mitochondria. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898063; 5091065 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chen, Y AU - Gerwin, C AU - Kang, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynein KW - Mitochondria KW - Light chains KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynein+Light+Chain+LC8+Regulates+Syntaphilin-mediated+Docking+of+Axonal+Mitochondria.&rft.au=Chen%2C+Y%3BGerwin%2C+C%3BKang%2C+J%3BSheng%2C+Z&rft.aulast=Chen&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CDC14 Dysfunction Leads to DNA Under-replication That Is Not Detected by Checkpoints. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41897355; 5089821 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Dulev, S AU - de Renty, C. AU - Schwob, E AU - Strunnikov, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - DNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=CDC14+Dysfunction+Leads+to+DNA+Under-replication+That+Is+Not+Detected+by+Checkpoints.&rft.au=Dulev%2C+S%3Bde+Renty%2C+C.%3BSchwob%2C+E%3BStrunnikov%2C+A&rft.aulast=Dulev&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Versatile Roles of a Splicegenerated C-terminal Extension of hCenexin1 in Polo-like Kinase 1 (Plk1)-dependent Mitotic Functions and Plk1-independent Ninein Recruitment and Ciliogenesis T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41890126; 5089033 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Soung, N AU - Yu, L. AU - Park, J AU - Lee, K AU - Lee, J AU - Veenstra, T AU - Rhee, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Recruitment KW - Polo-like kinase 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41890126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Versatile+Roles+of+a+Splicegenerated+C-terminal+Extension+of+hCenexin1+in+Polo-like+Kinase+1+%28Plk1%29-dependent+Mitotic+Functions+and+Plk1-independent+Ninein+Recruitment+and+Ciliogenesis&rft.au=Soung%2C+N%3BYu%2C+L.%3BPark%2C+J%3BLee%2C+K%3BLee%2C+J%3BVeenstra%2C+T%3BRhee%2C+K&rft.aulast=Soung&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane Fission: Lessons from Lipid Nanotubes and Dynamin. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41888706; 5088660 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Bashkirov, P AU - Sergey, A AU - Schmid, S AU - Zimmerberg, J AU - Frolov, V Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lipids KW - Nanotechnology KW - Membranes KW - Dynamin KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Membrane+Fission%3A+Lessons+from+Lipid+Nanotubes+and+Dynamin.&rft.au=Bashkirov%2C+P%3BSergey%2C+A%3BSchmid%2C+S%3BZimmerberg%2C+J%3BFrolov%2C+V&rft.aulast=Bashkirov&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell Biology in the Genomic Era T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41888614; 5088631 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Collins, Francis Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomics KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cell+Biology+in+the+Genomic+Era&rft.au=Collins%2C+Francis&rft.aulast=Collins&rft.aufirst=Francis&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epigenetic Genome Control by RNAi and Transposon-derived Proteins T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41883291; 5089401 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Grewal, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomes KW - RNA-mediated interference KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41883291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Epigenetic+Genome+Control+by+RNAi+and+Transposon-derived+Proteins&rft.au=Grewal%2C+S&rft.aulast=Grewal&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The N-terminal Regions of the HPS1 and HPS4 Proteins Are Required to Form the Biogenesis of Lysosome-related Organelle Complex 3 (BLOC-3). T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41883076; 5089358 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Carmona, C AU - Bonifacino, J AU - Cadilla, C AU - Gahl, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Organelles KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41883076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+N-terminal+Regions+of+the+HPS1+and+HPS4+Proteins+Are+Required+to+Form+the+Biogenesis+of+Lysosome-related+Organelle+Complex+3+%28BLOC-3%29.&rft.au=Carmona%2C+C%3BBonifacino%2C+J%3BCadilla%2C+C%3BGahl%2C+W&rft.aulast=Carmona&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deletion of the G2 Checkpoint Pathway Downstream Mediator of BRCA1, Wee1, in the Mammary Gland Results in Miscoordination of the Cell Cycle and Extensive DNA Damage. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41877729; 5089058 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Vasilopoulos, A AU - Tominaga, Y AU - Wang, R AU - Deng, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Downstream KW - Mammary gland KW - Cell cycle KW - DNA damage KW - BRCA1 protein KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Deletion+of+the+G2+Checkpoint+Pathway+Downstream+Mediator+of+BRCA1%2C+Wee1%2C+in+the+Mammary+Gland+Results+in+Miscoordination+of+the+Cell+Cycle+and+Extensive+DNA+Damage.&rft.au=Vasilopoulos%2C+A%3BTominaga%2C+Y%3BWang%2C+R%3BDeng%2C+C&rft.aulast=Vasilopoulos&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Traction Stress Variation across Single Focal Adhesions T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41877087; 5088792 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Plotnikov, S AU - Sabass, B AU - Schwarz, U AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Stress KW - Adhesion KW - Traction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Analysis+of+Traction+Stress+Variation+across+Single+Focal+Adhesions&rft.au=Plotnikov%2C+S%3BSabass%2C+B%3BSchwarz%2C+U%3BWaterman%2C+C&rft.aulast=Plotnikov&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of the Endocytic Pathway of ITIM-bearing Inhibitory Receptors: CD94/ NKG2A and LAIR-1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41874289; 5089539 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Peruzzi, G AU - Masilamani, M AU - Narayanan, S AU - Borrego, F AU - Coligan, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41874289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Study+of+the+Endocytic+Pathway+of+ITIM-bearing+Inhibitory+Receptors%3A+CD94%2F+NKG2A+and+LAIR-1.&rft.au=Peruzzi%2C+G%3BMasilamani%2C+M%3BNarayanan%2C+S%3BBorrego%2C+F%3BColigan%2C+J&rft.aulast=Peruzzi&rft.aufirst=G&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Condensin Is Essential for Centromeric Chromatin Assembly and Sister Kinetochore Orientation in Anaphase. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41870232; 5091329 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Samoshkin, A AU - Arnaoutov, A AU - Jansen, L AU - Ouispenski, I AU - Dye, L AU - Karpova, T AU - McNally, J AU - Dasso, M AU - Cleveland, D AU - Strunnikov, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetochores KW - Anaphase KW - Condensin KW - Chromatin remodeling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41870232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Condensin+Is+Essential+for+Centromeric+Chromatin+Assembly+and+Sister+Kinetochore+Orientation+in+Anaphase.&rft.au=Samoshkin%2C+A%3BArnaoutov%2C+A%3BJansen%2C+L%3BOuispenski%2C+I%3BDye%2C+L%3BKarpova%2C+T%3BMcNally%2C+J%3BDasso%2C+M%3BCleveland%2C+D%3BStrunnikov%2C+A&rft.aulast=Samoshkin&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - R-Spondin2/Int7 and Wnt-1 Stimulate Invasiveness and Tumorigenicity of Mammary Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41869222; 5090065 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Klauzinska, M AU - Raafat, A AU - Strizzi, L AU - Baljinnyam, B AU - Endo, Y AU - Rubin, J AU - Callahan, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Invasiveness KW - Epithelial cells KW - Mammary gland KW - Tumorigenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41869222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=R-Spondin2%2FInt7+and+Wnt-1+Stimulate+Invasiveness+and+Tumorigenicity+of+Mammary+Epithelial+Cells.&rft.au=Klauzinska%2C+M%3BRaafat%2C+A%3BStrizzi%2C+L%3BBaljinnyam%2C+B%3BEndo%2C+Y%3BRubin%2C+J%3BCallahan%2C+R&rft.aulast=Klauzinska&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein-free Liposomes Rescue Nuclear Envelope Formation by Fusion with Membrane Vesicles. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41868823; 5090704 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Rafikova, E AU - Melikov, K AU - Ramos, C AU - Dye, L AU - Chernomordik, L Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Nuclear membranes KW - Membrane vesicles KW - Membrane fusion KW - Liposomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Multiecho+dixon+fat+and+water+separation+method+for+detecting+fibrofatty+infiltration+in+the+myocardium&rft.au=Kellman%2C+Peter%3BHernando%2C+Diego%3BShah%2C+Saurabh%3BZuehlsdorff%2C+Sven%3BJerecic%2C+Renate%3BMancini%2C+Christine%3BLiang%2C+Zhi-Pei%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21657 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Position of Human Chromosomes Is Conserved in Mouse Nuclei Indicating a Species-independent Mechanism for Maintaining Genome Organization. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41867212; 5090152 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Sengupta, K AU - Camps, J AU - Mathews, P AU - Barenboim-Stapleton, L AU - Nguyen, Q AU - Difi lippantonio, M AU - Ried, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Chromosomes KW - Genomes KW - Nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Position+of+Human+Chromosomes+Is+Conserved+in+Mouse+Nuclei+Indicating+a+Species-independent+Mechanism+for+Maintaining+Genome+Organization.&rft.au=Sengupta%2C+K%3BCamps%2C+J%3BMathews%2C+P%3BBarenboim-Stapleton%2C+L%3BNguyen%2C+Q%3BDifi+lippantonio%2C+M%3BRied%2C+T&rft.aulast=Sengupta&rft.aufirst=K&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Th e Structure of Dynamin Family Members. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41866766; 5090129 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Mears, J AU - Fang, S AU - Ray, P AU - Heymann, J AU - Hinshaw, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41866766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Th+e+Structure+of+Dynamin+Family+Members.&rft.au=Mears%2C+J%3BFang%2C+S%3BRay%2C+P%3BHeymann%2C+J%3BHinshaw%2C+J&rft.aulast=Mears&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Varied Functions of Small, Non-coding RNAs in Bacteria. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41865673; 5090868 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Storz, G AU - Durand, S AU - Fontaine, F AU - Fozo, E AU - Opdyke, J AU - Waters, L AU - Zhang, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Non-coding RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41865673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Varied+Functions+of+Small%2C+Non-coding+RNAs+in+Bacteria.&rft.au=Storz%2C+G%3BDurand%2C+S%3BFontaine%2C+F%3BFozo%2C+E%3BOpdyke%2C+J%3BWaters%2C+L%3BZhang%2C+A&rft.aulast=Storz&rft.aufirst=G&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Medical+mycology&rft.issn=1460-2709&rft_id=info:doi/10.1080%2F13693780802056012 L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cleftin: A Novel Fibronectininduced Gene That Promotes Branching Morphogenesis. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864933; 5090239 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Onodera, T AU - Sakai, T AU - Yamada, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Morphogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cleftin%3A+A+Novel+Fibronectininduced+Gene+That+Promotes+Branching+Morphogenesis.&rft.au=Onodera%2C+T%3BSakai%2C+T%3BYamada%2C+K&rft.aulast=Onodera&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss-of-Function Mutations and Two-Furin Domain Derivatives Reveal Insights about R-spondin2 Structure and Activity. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864572; 5090575 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Li, S. AU - Yen, T AU - Endo, Y AU - Klauzinska, M AU - Baljinnyam, B AU - Macher, B AU - Callahan, R AU - Rubin, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mutation KW - Metabolites KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Loss-of-Function+Mutations+and+Two-Furin+Domain+Derivatives+Reveal+Insights+about+R-spondin2+Structure+and+Activity.&rft.au=Li%2C+S.%3BYen%2C+T%3BEndo%2C+Y%3BKlauzinska%2C+M%3BBaljinnyam%2C+B%3BMacher%2C+B%3BCallahan%2C+R%3BRubin%2C+J&rft.aulast=Li&rft.aufirst=S.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxysterol-binding Proteins Transfer Lipids at Organelle Contact Sites. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864195; 5090910 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Schulz, T AU - Choi, M AU - Mears, J AU - Hinshaw, J AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lipids KW - Organelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+reference+services+quarterly&rft.atitle=United+States+National+Library+of+Medicine+Drug+Information+Portal.&rft.au=Hochstein%2C+Colette%3BGoshorn%2C+Jeanne%3BChang%2C+Florence&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2009-01-01&rft.volume=28&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Medical+reference+services+quarterly&rft.issn=1540-9597&rft_id=info:doi/10.1080%2F02763860902816784 L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Synaptic Facilitation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41861609; 5090750 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kang, J AU - Pan, P AU - Tian, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mobility KW - Mitochondria KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Docking+of+Axonal+Mitochondria+by+Syntaphilin+Controls+Their+Mobility+and+Affects+Short-Term+Synaptic+Facilitation.&rft.au=Kang%2C+J%3BPan%2C+P%3BTian%2C+J%3BSheng%2C+Z&rft.aulast=Kang&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Throughput Screening, Probe Development, and the NIH Molecular Libraries Program T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41861099; 5088616 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Charya, Ananth AU - Colvis, Christine AU - Yao, Yong Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Probes KW - High-throughput screening KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=High-Throughput+Screening%2C+Probe+Development%2C+and+the+NIH+Molecular+Libraries+Program&rft.au=Charya%2C+Ananth%3BColvis%2C+Christine%3BYao%2C+Yong&rft.aulast=Charya&rft.aufirst=Ananth&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Is Essential for Focal Adhesion Assembly in Spreading Corneal Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860939; 5088783 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Pan, Q AU - Gao, C AU - Zelenka, P Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Epithelial cells KW - Cyclin-dependent kinase 5 KW - Cell migration KW - Cornea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Collection+and+preparation+of+rodent+tissue+samples+for+histopathological+and+molecular+studies+in+carcinogenesis.&rft.au=Golubeva%2C+Yelena%3BRogers%2C+Keith&rft.aulast=Golubeva&rft.aufirst=Yelena&rft.date=2009-01-01&rft.volume=511&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-447-6_1 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin II Activity Is Necessary for Growth Cone Turning at the Chondroitin Sulfate Proteoglycan Boundary. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860264; 5091188 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Santiago, L AU - Katagiri, Y AU - Geller, H Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Sulfate KW - Myosin KW - Growth cones KW - Chondroitin sulfate KW - Proteoglycans KW - Boundaries KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin+II+Activity+Is+Necessary+for+Growth+Cone+Turning+at+the+Chondroitin+Sulfate+Proteoglycan+Boundary.&rft.au=Santiago%2C+L%3BKatagiri%2C+Y%3BGeller%2C+H&rft.aulast=Santiago&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stable and Prolonged Contacts Form between Cilia of Adjacent Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860216; 5091183 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ott, C AU - Sengupta, P AU - Elia, N AU - Case, L AU - Lippincott- Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cilia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Stable+and+Prolonged+Contacts+Form+between+Cilia+of+Adjacent+Cells.&rft.au=Ott%2C+C%3BSengupta%2C+P%3BElia%2C+N%3BCase%2C+L%3BLippincott-+Schwartz%2C+J&rft.aulast=Ott&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modifications of Membrane Protein Diffusion in P. falciparum-infected Erythrocytes Studied by Quantum Dot-based Multi-particle Tracking. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860135; 5091374 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Tokumasu, F AU - Clarke, M AU - Crivat, G AU - Ostera, G AU - Hwang, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membrane proteins KW - Erythrocytes KW - Diffusion KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Modifications+of+Membrane+Protein+Diffusion+in+P.+falciparum-infected+Erythrocytes+Studied+by+Quantum+Dot-based+Multi-particle+Tracking.&rft.au=Tokumasu%2C+F%3BClarke%2C+M%3BCrivat%2C+G%3BOstera%2C+G%3BHwang%2C+J&rft.aulast=Tokumasu&rft.aufirst=F&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role of Snapin in Coordinating Late Endocytic Trafficking and Autophagy-Lysosomal Function T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859938; 5088715 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Cai, Q AU - Lu, L. AU - Tian, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Essential+Role+of+Snapin+in+Coordinating+Late+Endocytic+Trafficking+and+Autophagy-Lysosomal+Function&rft.au=Cai%2C+Q%3BLu%2C+L.%3BTian%2C+J%3BSheng%2C+Z&rft.aulast=Cai&rft.aufirst=Q&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biased Gliding of Magnetized Actin Cytoskeleton in Applied Magnetic Field. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859586; 5091267 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chen, Y AU - Conroy, R AU - Sumner, J AU - Moreland, J AU - Koretsky, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cytoskeleton KW - Actin KW - Magnetic fields KW - Gliding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Biased+Gliding+of+Magnetized+Actin+Cytoskeleton+in+Applied+Magnetic+Field.&rft.au=Chen%2C+Y%3BConroy%2C+R%3BSumner%2C+J%3BMoreland%2C+J%3BKoretsky%2C+A&rft.aulast=Chen&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Th e Spatial Organization of Genomes T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859575; 5088640 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Misteli, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Th+e+Spatial+Organization+of+Genomes&rft.au=Misteli%2C+T&rft.aulast=Misteli&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin II Mediates Local Cortical Tension to Guide Endothelial Cell Branching Morphogenesis and Migration in 3D. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859166; 5090424 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Fischer, R AU - Gardel, M AU - Ma, X. AU - Adelstein, R AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Myosin KW - Cell migration KW - Endothelial cells KW - Cortex KW - Morphogenesis KW - Tension KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin+II+Mediates+Local+Cortical+Tension+to+Guide+Endothelial+Cell+Branching+Morphogenesis+and+Migration+in+3D.&rft.au=Fischer%2C+R%3BGardel%2C+M%3BMa%2C+X.%3BAdelstein%2C+R%3BWaterman%2C+C&rft.aulast=Fischer&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bridging Engineering and Life Sciences: Next Generation Tools for Cell Biology T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858941; 5088612 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lee, Jerry Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Bridging+Engineering+and+Life+Sciences%3A+Next+Generation+Tools+for+Cell+Biology&rft.au=Lee%2C+Jerry&rft.aulast=Lee&rft.aufirst=Jerry&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of PolD3 Accessory Subunit in AID-mediated Mutagenesis and Recombination. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858873; 5091548 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Poltoratsky, V AU - Horton, J AU - Wilson, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mutagenesis KW - Recombination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+PolD3+Accessory+Subunit+in+AID-mediated+Mutagenesis+and+Recombination.&rft.au=Poltoratsky%2C+V%3BHorton%2C+J%3BWilson%2C+S&rft.aulast=Poltoratsky&rft.aufirst=V&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Localized Production of RanGTP at the Chromatin-Cytoplasm Interface Is Sufficient and Required for Bipolar Mitotic Spindle Assembly in Xenopus laevis Egg Extracts. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858092; 5090519 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kalab, P AU - Halpin, D AU - Heald, R AU - Weis, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Spindles KW - Amphibiotic species KW - Xenopus laevis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Localized+Production+of+RanGTP+at+the+Chromatin-Cytoplasm+Interface+Is+Sufficient+and+Required+for+Bipolar+Mitotic+Spindle+Assembly+in+Xenopus+laevis+Egg+Extracts.&rft.au=Kalab%2C+P%3BHalpin%2C+D%3BHeald%2C+R%3BWeis%2C+K&rft.aulast=Kalab&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myofibril Assembly Visualized by Imaging N-RAP, Alpha-Actinin, and Actin in Living Cardiomyocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857816; 5089671 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Manisastry, S AU - Zaal, K AU - Horowits, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cardiomyocytes KW - Actin KW - Imaging techniques KW - Myofibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myofibril+Assembly+Visualized+by+Imaging+N-RAP%2C+Alpha-Actinin%2C+and+Actin+in+Living+Cardiomyocytes.&rft.au=Manisastry%2C+S%3BZaal%2C+K%3BHorowits%2C+R&rft.aulast=Manisastry&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetic Characterization of the Myosin IIA with an N-terminal GFP Fused Regulatory Light Chain. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857786; 5090427 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kengyel, A AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetics KW - Myosin KW - Light chains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Kinetic+Characterization+of+the+Myosin+IIA+with+an+N-terminal+GFP+Fused+Regulatory+Light+Chain.&rft.au=Kengyel%2C+A%3BSellers%2C+J&rft.aulast=Kengyel&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PIPs Modulate the Sterol Affinity of Oxysterol Binding Proteins at Membrane Contact Sites. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857724; 5088858 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Schulz, T AU - Chung, R AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membranes KW - Sterols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=PIPs+Modulate+the+Sterol+Affinity+of+Oxysterol+Binding+Proteins+at+Membrane+Contact+Sites.&rft.au=Schulz%2C+T%3BChung%2C+R%3BPrinz%2C+W&rft.aulast=Schulz&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomics Analysis of Focal Adhesion Maturation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857468; 5088794 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kuo, J AU - Han, X AU - Yates, J AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Proteomics KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Proteomics+Analysis+of+Focal+Adhesion+Maturation.&rft.au=Kuo%2C+J%3BHan%2C+X%3BYates%2C+J%3BWaterman%2C+C&rft.aulast=Kuo&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Del-1 (Developmental Endothelial Locus-1) Is an Endogenous Inhibitor of Leukocyte-Endothelial Adhesion Limiting Inflammatory Cell Recruitment. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857383; 5090979 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Choi, E AU - Chavakis, E AU - Czabanka, M AU - Langer, H AU - Fraemohs, L AU - Economopoulou, M AU - Kundu, R AU - Gahmberg, C AU - Udey, M AU - Vajkoczy, P AU - Quertermous, T AU - Dimmeler, S AU - Weber, C AU - Chavakis, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Recruitment KW - Inflammation KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Del-1+%28Developmental+Endothelial+Locus-1%29+Is+an+Endogenous+Inhibitor+of+Leukocyte-Endothelial+Adhesion+Limiting+Inflammatory+Cell+Recruitment.&rft.au=Choi%2C+E%3BChavakis%2C+E%3BCzabanka%2C+M%3BLanger%2C+H%3BFraemohs%2C+L%3BEconomopoulou%2C+M%3BKundu%2C+R%3BGahmberg%2C+C%3BUdey%2C+M%3BVajkoczy%2C+P%3BQuertermous%2C+T%3BDimmeler%2C+S%3BWeber%2C+C%3BChavakis%2C+T&rft.aulast=Choi&rft.aufirst=E&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Microtubule Plus End- Binding Protein EB1 Is Necessary for Muscle Cell Differentiation, Elongation, and Fusion. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857070; 5088910 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Zhang, T AU - Zaal, K AU - Reid, E AU - Sheridan, J AU - Mehta, A AU - Gundersen, G AU - Ralston, E Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Muscles KW - Cell differentiation KW - Differentiation KW - Microtubules KW - Elongation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Microtubule+Plus+End-+Binding+Protein+EB1+Is+Necessary+for+Muscle+Cell+Differentiation%2C+Elongation%2C+and+Fusion.&rft.au=Zhang%2C+T%3BZaal%2C+K%3BReid%2C+E%3BSheridan%2C+J%3BMehta%2C+A%3BGundersen%2C+G%3BRalston%2C+E&rft.aulast=Zhang&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nup107-160 Complex and - TuRC Regulate Microtubule Polymerization at Kinetochores. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41855275; 5089796 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Mishra, R AU - Chakraborty, P AU - Arnaoutov, A AU - Fontoura, B AU - Dasso, M Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetochores KW - Microtubules KW - Polymerization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Nup107-160+Complex+and+-+TuRC+Regulate+Microtubule+Polymerization+at+Kinetochores.&rft.au=Mishra%2C+R%3BChakraborty%2C+P%3BArnaoutov%2C+A%3BFontoura%2C+B%3BDasso%2C+M&rft.aulast=Mishra&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of TRPC1-Interacting Proteins by Tandem Mass Spectroscopy. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854988; 5090308 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lockwich, T AU - Makusky, A AU - Kowalak, J AU - Markey, S AU - Ambudkar, I Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mass spectroscopy KW - Trp protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Analysis+of+TRPC1-Interacting+Proteins+by+Tandem+Mass+Spectroscopy.&rft.au=Lockwich%2C+T%3BMakusky%2C+A%3BKowalak%2C+J%3BMarkey%2C+S%3BAmbudkar%2C+I&rft.aulast=Lockwich&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LRRK2 Regulates Neurite Outgrowth via Modulation of ERM Phosphorylation and Actin Remodeling. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854950; 5091589 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Parisiadou, L AU - Xie, C AU - Wang, L AU - Gu, X. AU - Lin, X AU - Shim, H AU - Li, Z. AU - Cai, H Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - LRRK2 protein KW - Actin KW - Phosphorylation KW - Axonogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=LRRK2+Regulates+Neurite+Outgrowth+via+Modulation+of+ERM+Phosphorylation+and+Actin+Remodeling.&rft.au=Parisiadou%2C+L%3BXie%2C+C%3BWang%2C+L%3BGu%2C+X.%3BLin%2C+X%3BShim%2C+H%3BLi%2C+Z.%3BCai%2C+H&rft.aulast=Parisiadou&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the Penta-EF-Hand Protein ALG-2 as a Ca2+-dependent Interactor of Mucolipin-1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854888; 5089447 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Vergarajauregui, S AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Calcium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Identification+of+the+Penta-EF-Hand+Protein+ALG-2+as+a+Ca2%2B-dependent+Interactor+of+Mucolipin-1.&rft.au=Vergarajauregui%2C+S%3BPuertollano%2C+R&rft.aulast=Vergarajauregui&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Reticulons and DP1/ Yop1p in Maintaining ER Tubules. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854681; 5090207 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Voss, C AU - Shibata, Y AU - Rapoport, T AU - Voeltz, G AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Tubules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+Reticulons+and+DP1%2F+Yop1p+in+Maintaining+ER+Tubules.&rft.au=Voss%2C+C%3BShibata%2C+Y%3BRapoport%2C+T%3BVoeltz%2C+G%3BPrinz%2C+W&rft.aulast=Voss&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule Kinetic Measurements of Non-Muscle Myosin IIB Using Optical Tweezers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854641; 5090428 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Nagy, A AU - Takagi, Y AU - Kovacs, M AU - Homsher, E AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetics KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Single+Molecule+Kinetic+Measurements+of+Non-Muscle+Myosin+IIB+Using+Optical+Tweezers.&rft.au=Nagy%2C+A%3BTakagi%2C+Y%3BKovacs%2C+M%3BHomsher%2C+E%3BSellers%2C+J&rft.aulast=Nagy&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Uptake and Trafficking of Fluorescently Conjugated Dextran and Transferrin: A Comparison of Salivary Gland Fibroblasts in Live Rodents and Isolated Fibroblasts in Culture. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854206; 5090353 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Masedunskas, A AU - Weigert, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Rodents KW - Fibroblasts KW - Transferrin KW - Salivary gland KW - Dextran KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Uptake+and+Trafficking+of+Fluorescently+Conjugated+Dextran+and+Transferrin%3A+A+Comparison+of+Salivary+Gland+Fibroblasts+in+Live+Rodents+and+Isolated+Fibroblasts+in+Culture.&rft.au=Masedunskas%2C+A%3BWeigert%2C+R&rft.aulast=Masedunskas&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Snapin Plays a Key Role as an Adaptor for CPE Cytoplasmic Tail to Connect Hormone Vesicles to Microtubule Motor Complex. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853678; 5089584 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Park, J AU - Loh, Y Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Hormones KW - Microtubules KW - Vesicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Snapin+Plays+a+Key+Role+as+an+Adaptor+for+CPE+Cytoplasmic+Tail+to+Connect+Hormone+Vesicles+to+Microtubule+Motor+Complex.&rft.au=Park%2C+J%3BLoh%2C+Y&rft.aulast=Park&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MCOLN3 Is Involved in the Trafficking of Cargo Proteins along the Endo/ lysosomal Compartment in the Retinal Pigment Epithelial Cell Line ARPE-19. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853647; 5089446 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Martina, J AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Pigments KW - Retinal pigment epithelium KW - Retina KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=MCOLN3+Is+Involved+in+the+Trafficking+of+Cargo+Proteins+along+the+Endo%2F+lysosomal+Compartment+in+the+Retinal+Pigment+Epithelial+Cell+Line+ARPE-19.&rft.au=Martina%2C+J%3BPuertollano%2C+R&rft.aulast=Martina&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sorting Nexin 27: A Novel Regulator of CFTR Trafficking. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853598; 5089443 JF - 48th Annual Meeting of the American Society for Cell Biology AU - McDermott, M AU - Thelin, W AU - Lyons, P AU - Gentzsch, M AU - Hong, W AU - Stutts, M AU - Milgram, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Nexin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Sorting+Nexin+27%3A+A+Novel+Regulator+of+CFTR+Trafficking.&rft.au=McDermott%2C+M%3BThelin%2C+W%3BLyons%2C+P%3BGentzsch%2C+M%3BHong%2C+W%3BStutts%2C+M%3BMilgram%2C+S&rft.aulast=McDermott&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Angiotensin IIInduced ERK1/2 Activation in Primary Fetal Cardiomyocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853355; 5089877 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Yin, X AU - Zhang, M AU - Hu, L. AU - Catt, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cardiomyocytes KW - Angiotensin KW - Fetuses KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Mechanism+of+Angiotensin+IIInduced+ERK1%2F2+Activation+in+Primary+Fetal+Cardiomyocytes.&rft.au=Yin%2C+X%3BZhang%2C+M%3BHu%2C+L.%3BCatt%2C+K&rft.aulast=Yin&rft.aufirst=X&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin Regulates Apical Constriction in Epithelial Monolayers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853253; 5089599 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chua, J AU - Rikhy, R AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynamin KW - Monomolecular films KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynamin+Regulates+Apical+Constriction+in+Epithelial+Monolayers.&rft.au=Chua%2C+J%3BRikhy%2C+R%3BLippincott-Schwartz%2C+J&rft.aulast=Chua&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Targeting of Misfolded Proteins in the Endoplasmic Reticulum for Degradation by Autophagy. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851398; 5090942 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Satpute- Krishnan, P AU - Hegde, R AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Degradation KW - Protein folding KW - Endoplasmic reticulum KW - Phagocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Selective+Targeting+of+Misfolded+Proteins+in+the+Endoplasmic+Reticulum+for+Degradation+by+Autophagy.&rft.au=Satpute-+Krishnan%2C+P%3BHegde%2C+R%3BLippincott-Schwartz%2C+J&rft.aulast=Satpute-+Krishnan&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SIRT1 Inhibitor Alleviates FMR1 Gene Silencing in Fragile X Cell Lines T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851248; 5091415 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Biacsi, R AU - Kumari, D AU - Usdin, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Gene silencing KW - SIRT1 protein KW - Fragile X mental retardation protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=SIRT1+Inhibitor+Alleviates+FMR1+Gene+Silencing+in+Fragile+X+Cell+Lines&rft.au=Biacsi%2C+R%3BKumari%2C+D%3BUsdin%2C+K&rft.aulast=Biacsi&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Nef Mediates Ubiquitination-independent Targeting of CD4 to the MVB Pathway. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851107; 5090853 JF - 48th Annual Meeting of the American Society for Cell Biology AU - daSilva, L AU - Sougrat, R AU - Burgos, P AU - Janvier, K AU - Bonifacino, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Nef protein KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=HIV-1+Nef+Mediates+Ubiquitination-independent+Targeting+of+CD4+to+the+MVB+Pathway.&rft.au=daSilva%2C+L%3BSougrat%2C+R%3BBurgos%2C+P%3BJanvier%2C+K%3BBonifacino%2C+J&rft.aulast=daSilva&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Activity Regulates Cytoskeletal Organization by Controlling Rhodependent Myosin Phosphorylation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849910; 5091137 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Tripathi, B AU - Gao, C AU - Zelenka, P Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Cytoskeleton KW - Cyclin-dependent kinase 5 KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cdk5+Activity+Regulates+Cytoskeletal+Organization+by+Controlling+Rhodependent+Myosin+Phosphorylation.&rft.au=Tripathi%2C+B%3BGao%2C+C%3BZelenka%2C+P&rft.aulast=Tripathi&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topology Rather than Cell Lineage Determines the Presence of the Subcortical Maternal Complex in Preimplantation Mouse Development. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849882; 5090763 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Baibakov, B AU - Li, L. AU - Dean, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cell lineage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Topology+Rather+than+Cell+Lineage+Determines+the+Presence+of+the+Subcortical+Maternal+Complex+in+Preimplantation+Mouse+Development.&rft.au=Baibakov%2C+B%3BLi%2C+L.%3BDean%2C+J&rft.aulast=Baibakov&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Distribution of the Feminization Factor Homolog Fem1b in Human Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849564; 5090925 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lelouvier, B AU - Martina, J AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Epithelial cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Intracellular+Distribution+of+the+Feminization+Factor+Homolog+Fem1b+in+Human+Epithelial+Cells.&rft.au=Lelouvier%2C+B%3BMartina%2C+J%3BPuertollano%2C+R&rft.aulast=Lelouvier&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin Regulates Actin Cytoskeleton Remodeling for Metaphase Furrow Formation through Diaphanous in the Syncytial Drosophila Blastoderm. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41848536; 5091451 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Rikhy, R AU - Mavrakis, M AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Metaphase KW - Cytoskeleton KW - Blastoderm KW - Actin KW - Dynamin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynamin+Regulates+Actin+Cytoskeleton+Remodeling+for+Metaphase+Furrow+Formation+through+Diaphanous+in+the+Syncytial+Drosophila+Blastoderm.&rft.au=Rikhy%2C+R%3BMavrakis%2C+M%3BLippincott-Schwartz%2C+J&rft.aulast=Rikhy&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Sel1-domain Protein EnhC in Host Cell Entry by the Obligate Intracellular Bacterium Coxiella burnetii. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844921; 5089308 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Gilk, S AU - Cirillo, S AU - Cirillo, J AU - Heinzen, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Proteins KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+the+Sel1-domain+Protein+EnhC+in+Host+Cell+Entry+by+the+Obligate+Intracellular+Bacterium+Coxiella+burnetii.&rft.au=Gilk%2C+S%3BCirillo%2C+S%3BCirillo%2C+J%3BHeinzen%2C+R&rft.aulast=Gilk&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel E3 Ubiquitin Ligase LNXL Determines Dorso-Ventral Body Patterning by Negatively Regulating Bozozok Stability T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844900; 5089225 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ro, H. AU - Dawid, I Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Ubiquitin-protein ligase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Novel+E3+Ubiquitin+Ligase+LNXL+Determines+Dorso-Ventral+Body+Patterning+by+Negatively+Regulating+Bozozok+Stability&rft.au=Ro%2C+H.%3BDawid%2C+I&rft.aulast=Ro&rft.aufirst=H.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tubulin Binding to Mitochondrial Outer Membrane through Interaction of the C-terminal "Tails" with VDAC Regulates Respiration - Biophysics, Physiology, and Evolution. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844790; 5090398 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Sherm, J AU - Rostovtseva, T AU - Monge, C AU - Sheldon, K AU - Wolff, J AU - Saks, V AU - Bezrukov, S AU - Sackett, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Respiration KW - Outer membranes KW - Physiology KW - Biophysics KW - Mitochondria KW - Tubulin KW - Electron transport KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Tubulin+Binding+to+Mitochondrial+Outer+Membrane+through+Interaction+of+the+C-terminal+%22Tails%22+with+VDAC+Regulates+Respiration+-+Biophysics%2C+Physiology%2C+and+Evolution.&rft.au=Sherm%2C+J%3BRostovtseva%2C+T%3BMonge%2C+C%3BSheldon%2C+K%3BWolff%2C+J%3BSaks%2C+V%3BBezrukov%2C+S%3BSackett%2C+D&rft.aulast=Sherm&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Trafficking Routes for Cargo Proteins Entering Cells via Clathrinindependent Endocytosis. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844544; 5090354 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Eyster, C AU - Huebner, R AU - Higginson, J AU - Porat-Shliom, N AU - Weigert, R AU - Donaldson, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Endocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=New+Trafficking+Routes+for+Cargo+Proteins+Entering+Cells+via+Clathrinindependent+Endocytosis.&rft.au=Eyster%2C+C%3BHuebner%2C+R%3BHigginson%2C+J%3BPorat-Shliom%2C+N%3BWeigert%2C+R%3BDonaldson%2C+J&rft.aulast=Eyster&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SirT1 Represses MMP13 Expression in Human Articular Chondrocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844195; 5089455 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lee, E AU - Gagarina, V AU - Dvir-Ginzburg, M AU - Hall, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Collagenase 3 KW - Chondrocytes KW - SIRT1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=SirT1+Represses+MMP13+Expression+in+Human+Articular+Chondrocytes.&rft.au=Lee%2C+E%3BGagarina%2C+V%3BDvir-Ginzburg%2C+M%3BHall%2C+D&rft.aulast=Lee&rft.aufirst=E&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nonmuscle Myosin II-A Motor Domain Is Important for Early Mouse Embryonic Development. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844122; 5090426 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Wang, A AU - Ma, X. AU - Adelstein, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Embryogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Nonmuscle+Myosin+II-A+Motor+Domain+Is+Important+for+Early+Mouse+Embryonic+Development.&rft.au=Wang%2C+A%3BMa%2C+X.%3BAdelstein%2C+R&rft.aulast=Wang&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Effect of Ablation of Nonmuscle Myosin II-B and II-C on Karyokinesis in Mouse Cardiac Myocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844078; 5090425 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ma, X. AU - Kawamoto, S AU - Conti, M AU - Jana, S AU - Adelstein, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Synergistic effects KW - Cardiomyocytes KW - Myosin KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Synergistic+Effect+of+Ablation+of+Nonmuscle+Myosin+II-B+and+II-C+on+Karyokinesis+in+Mouse+Cardiac+Myocytes.&rft.au=Ma%2C+X.%3BKawamoto%2C+S%3BConti%2C+M%3BJana%2C+S%3BAdelstein%2C+R&rft.aulast=Ma&rft.aufirst=X.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of Anthrax Lethal Toxin: Impact of the N-Terminal Amino Acid. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41843124; 5089356 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Gupta, P AU - Moayeri, M AU - Leppla, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Anthrax lethal toxin KW - Amino acids KW - Toxins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Activity+of+Anthrax+Lethal+Toxin%3A+Impact+of+the+N-Terminal+Amino+Acid.&rft.au=Gupta%2C+P%3BMoayeri%2C+M%3BLeppla%2C+S&rft.aulast=Gupta&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of NHERF-1 in the Regulation of T Lymphocyte Adhesion and Migration. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41843022; 5089731 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ben Aissa, K AU - Liu, Y AU - Shomer, I AU - Hao, J AU - Steplock, D AU - Weinman, E AU - Shaw, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Adhesion KW - Lymphocytes KW - Leukocyte migration KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+NHERF-1+in+the+Regulation+of+T+Lymphocyte+Adhesion+and+Migration.&rft.au=Ben+Aissa%2C+K%3BLiu%2C+Y%3BShomer%2C+I%3BHao%2C+J%3BSteplock%2C+D%3BWeinman%2C+E%3BShaw%2C+S&rft.aulast=Ben+Aissa&rft.aufirst=K&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Queen's University T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41842923; 5089351 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Li, H. AU - Lee, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cancer KW - Genetics KW - Pathology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Pathology+and+Molecular+Medicine%2C+Division+of+Cancer+Biology+and+Genetics%2C+Queen%27s+University&rft.au=Li%2C+H.%3BLee%2C+S&rft.aulast=Li&rft.aufirst=H.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three Dimensional Superresolution Fluorescence Microscopy Reveals Protein Stratification in Focal Adhesions. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41842158; 5088793 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kanchanawong, P AU - Shtengel, G AU - Davidson, M AU - Hess, H AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Stratification KW - Fluorescence microscopy KW - Adhesion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Three+Dimensional+Superresolution+Fluorescence+Microscopy+Reveals+Protein+Stratification+in+Focal+Adhesions.&rft.au=Kanchanawong%2C+P%3BShtengel%2C+G%3BDavidson%2C+M%3BHess%2C+H%3BWaterman%2C+C&rft.aulast=Kanchanawong&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LOK is the Dominant ERM Kinase in Resting Lymphocytes and Regulates Cytoskeletal Rearrangement through ERM Phosphorylation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41838732; 5089616 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Belkina, N AU - Liu, Y AU - Hao, J AU - Shaw, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lymphocytes KW - Cytoskeleton KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=LOK+is+the+Dominant+ERM+Kinase+in+Resting+Lymphocytes+and+Regulates+Cytoskeletal+Rearrangement+through+ERM+Phosphorylation.&rft.au=Belkina%2C+N%3BLiu%2C+Y%3BHao%2C+J%3BShaw%2C+S&rft.aulast=Belkina&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determinants of the Specificity of Plk1 PBD Binding and Development of a Highly Sensitive Plk1 ELISA Assay. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41838133; 5089806 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Park, J AU - Moulaei, T AU - Lim, D AU - Kang, Y AU - Strebhardt, K AU - Yaffe, M AU - Wlodawer, A AU - Lee, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Polo-like kinase 1 KW - ELISA KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Determinants+of+the+Specificity+of+Plk1+PBD+Binding+and+Development+of+a+Highly+Sensitive+Plk1+ELISA+Assay.&rft.au=Park%2C+J%3BMoulaei%2C+T%3BLim%2C+D%3BKang%2C+Y%3BStrebhardt%2C+K%3BYaffe%2C+M%3BWlodawer%2C+A%3BLee%2C+K&rft.aulast=Park&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - UV radiation regulates Mi-2 through protein translation and stability. AN - 69866902; 18922793 AB - Dermatomyositis (DM) is an autoimmune disease, which is often accompanied by the development of disease-specific autoantibodies directed against the SNF2-superfamily helicase, Mi-2. Recent evidence suggests that ultraviolet radiation exposure may be an important risk factor for the development of not only the disease but also specific autoimmunity against Mi-2. Consequently, we investigated the effects of ultraviolet radiation on Mi-2 protein expression. We observed an increase in protein levels upon ultraviolet radiation exposure in cell culture systems. These changes in expression occur quite rapidly, are maximized just 1 h following exposure, and are unique to Mi-2 when compared with other members of the NuRD complex. Changes in protein levels are not mediated through transcriptional mechanisms. Treatment results in a more efficiently translated message through regulatory elements in the 5'-UTR region of the transcript. Investigation into protein half-life further demonstrated increased stability of Mi-2 following UV exposure. Taken together, we describe a system by which Mi-2 protein expression can be quickly increased following UV exposure and then maintained up to 16 h later. These data provide a novel regulation of an important transcriptional regulator and provide insight into the possible mechanisms of the development of DM and associated autoantibodies. JF - The Journal of biological chemistry AU - Burd, Craig J AU - Kinyamu, H Karimi AU - Miller, Frederick W AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Intitutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 34976 EP - 34982 VL - 283 IS - 50 SN - 0021-9258, 0021-9258 KW - 5' Untranslated Regions KW - 0 KW - Autoantibodies KW - Autoantigens KW - CHD4 protein, human KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - EC 3.5.1.98 KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Plasmids -- metabolism KW - Humans KW - Autoantibodies -- chemistry KW - Transcription, Genetic KW - Cell Line, Tumor KW - Cell Separation KW - Models, Biological KW - Risk Factors KW - Flow Cytometry KW - Keratinocytes -- metabolism KW - Time Factors KW - Ultraviolet Rays KW - DNA Helicases -- metabolism KW - Protein Biosynthesis -- radiation effects KW - Autoantigens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69866902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=UV+radiation+regulates+Mi-2+through+protein+translation+and+stability.&rft.au=Burd%2C+Craig+J%3BKinyamu%2C+H+Karimi%3BMiller%2C+Frederick+W%3BArcher%2C+Trevor+K&rft.aulast=Burd&rft.aufirst=Craig&rft.date=2008-12-12&rft.volume=283&rft.issue=50&rft.spage=34976&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M805383200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Dec 15;59(24):6087-90 [10626795] Nature. 1998 Oct 29;395(6705):917-21 [9804427] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9209-14 [10922072] Nature. 2002 Aug 29;418(6901):994-8 [12198550] Mol Cell. 2002 Dec;10(6):1441-52 [12504018] Rheumatology (Oxford). 2003 Jan;42(1):34-9 [12509610] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8354-9 [12821781] Arthritis Rheum. 2003 Aug;48(8):2285-93 [12905483] Semin Oncol. 2003 Oct;30(5 Suppl 16):30-7 [14613024] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):3-11 [15020040] Immunity. 2004 Jun;20(6):719-33 [15189737] Arthritis Rheum. 1985 Jul;28(7):796-803 [2409985] Am J Med. 1994 May;96(5):457-62 [8192178] J Rheumatol. 1998 Feb;25(2):395-6 [9489847] Mol Cell. 1998 Dec;2(6):851-61 [9885572] Immunity. 1999 Mar;10(3):345-55 [10204490] Mol Endocrinol. 2004 Dec;18(12):2937-49 [15358836] J Exp Med. 2005 Feb 21;201(4):591-601 [15728237] Curr Rheumatol Rep. 2005 Apr;7(2):99-105 [15760588] Autoimmunity. 2005 Feb;38(1):79-83 [15966133] Cell. 2005 Oct 7;123(1):49-63 [16213212] EMBO J. 2006 Sep 6;25(17):3986-97 [16932743] Clin Dermatol. 2006 Sep-Oct;24(5):363-73 [16966018] Curr Opin Rheumatol. 2006 Nov;18(6):620-4 [17053509] Joint Bone Spine. 2006 Dec;73(6):646-54 [17110150] J Biol Chem. 2007 May 11;282(19):13994-4005 [17344210] Oncogene. 2007 Aug 13;26(37):5433-8 [17694084] Mol Biol Cell. 2007 Sep;18(9):3667-80 [17626165] Mol Endocrinol. 2007 Dec;21(12):2907-18 [17761946] Nat Clin Pract Rheumatol. 2008 Apr;4(4):201-9 [18319710] Curr Biol. 1998 Jul 2;8(14):843-6 [9663395] Cell. 1998 Oct 16;95(2):279-89 [9790534] J Biol Chem. 2000 Jun 9;275(23):17771-7 [10748103] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M805383200 ER - TY - JOUR T1 - Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study AN - 20734936; 8934121 AB - Background Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric add concentration and gout. Methods Genome-wide association studies were done for serum uric add in 7699 participants in the Framingham cohort and in 4148 participants in the Rotterdam cohort. Genome-wide significant single nudeotide polymorphisms (SNPs) were replicated in white (n=11 024) and black (n=3843) individuals who took part in the study of Atherosderosis Risk in Communities (ARIC). The SNPs that readied genome-wide significant association with uric add in either the Framingham cohort (p<5 times 0x10 super(-8)) or the Rotterdam cohort (p<1 times 0x10 super(-7)) were evaluated with gout The results obtained in white participants were combined using meta-analysis. Findings Three loci in the Framingham cohort and two in the Rotterdam cohort showed genome-wide association with uric add. Top SNPs in each locus were: missense rs16890979 in SLC2A9 (p=7 times 0x10 super(-168) and 2 times 9x10 super(-18) for white and black participants, respectively); missense rs2231142 in ABCG2 (p=2 times 5x10 super(-60) and 9 times 8x10 super(-4)), and rs1165205 in SLC17A3 (p=3 times 3x10 super(-26) and 0.33). All SNPs were direction-consistent with gout in white participants: rs16890979 (OR 0 times 59 per T allele, 95% CI 0 times 52-0.68, p=7 times 0x10 super(-14)), rs2231142 (1 times 74, 1 times 51-1 times 99, p=3 times 3x10 super(-15)), and rs1165205 (0 times 85, 0 times 77-0 times 94, p=0 times 002). In black partidpants of the ARIC study, rs2231142 was direction-consistent with gout (1 times 71, 1 times 06-2 times 77, p=0 times 028). An additive genetic risk score of high-risk alleles at the three loci showed graded associations with uric add (272-351 mu mol/L in the Framingham cohort, 269-386 mu mol/L in the Rotterdam cohort, and 303-426 mu mol/L in white participants of the ARIC study) and gout (frequency 2-13% in the Framingham cohort, 2-8% in the Rotterdam cohort, and 1-18% in white participants in the ARIC study). Interpretation We identified three genetic loci associated with uric add concentration and gout. A score based on genes with a putative role in renal urate handling showed a substantial risk for gout Funding Netherlands Organisation for Scientific Research (NWO); the National Heart, Lung, and Blood Institute. JF - Lancet AU - Dehghan, A AU - Koettgen, A AU - Yang, Q AU - Hwang, S-J AU - Kao, WHL AU - Rivadeneira, F AU - Boerwinkle, E AU - Levy, D AU - Hofman, A AU - Astor, B C AU - Benjamin, E J AU - van Duijn, CM AU - Wittemant, J C AU - Coresht, J AU - Foxt, C S AD - National Heart Lung and Blood Institute, the Framingham Heart Study, 73 Mount Wayte Avenue Suite 2, Framinqham, MA 01702, USA, foxca@nhlbi.nih.gov Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 1953 EP - 1961 VL - 372 IS - 9654 SN - 0140-6736, 0140-6736 KW - Genetics Abstracts; Risk Abstracts KW - Heart KW - Netherlands, Rotterdam KW - Gout KW - Blood KW - Renal function KW - Single-nucleotide polymorphism KW - Lung KW - Risk factors KW - Reviews KW - Kidney KW - Risk groups KW - Netherlands KW - Additives KW - Uric acid KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20734936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Association+of+three+genetic+loci+with+uric+acid+concentration+and+risk+of+gout%3A+a+genome-wide+association+study&rft.au=Dehghan%2C+A%3BKoettgen%2C+A%3BYang%2C+Q%3BHwang%2C+S-J%3BKao%2C+WHL%3BRivadeneira%2C+F%3BBoerwinkle%2C+E%3BLevy%2C+D%3BHofman%2C+A%3BAstor%2C+B+C%3BBenjamin%2C+E+J%3Bvan+Duijn%2C+CM%3BWittemant%2C+J+C%3BCoresht%2C+J%3BFoxt%2C+C+S&rft.aulast=Dehghan&rft.aufirst=A&rft.date=2008-12-12&rft.volume=372&rft.issue=9654&rft.spage=1953&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2808%2961343-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Blood; Renal function; Lung; Single-nucleotide polymorphism; Reviews; Risk factors; Kidney; Risk groups; Gout; Uric acid; Additives; Netherlands, Rotterdam; Netherlands DO - http://dx.doi.org/10.1016/S0140-6736(08)61343-4 ER - TY - JOUR T1 - The High-Resolution NMR Structure of the Early Folding Intermediate of the Thermus thermophilus Ribonuclease H AN - 19805151; 8851096 AB - Elucidation of the high-resolution structures of folding intermediates is a necessary but difficult step toward the ultimate understanding of the mechanism of protein folding. Here, using hydrogen-exchange-directed protein engineering, we populated the folding intermediate of the Thermus thermophilus ribonuclease H, which forms before the rate-limiting transition state, by removing the unfolded regions of the intermediate, including an a-helix and two b-strands (51 folded residues). Using multidimensional NMR, we solved the structure of this intermediate mimic to an atomic resolution (backbone rmsd, 0.51 A). It has a native-like backbone topology and shows some local deviations from the native structure, revealing that the structure of the folded region of an early folding intermediate can be as well defined as the native structure. The topological parameters calculated from the structures of the intermediate mimic and the native state predict that the intermediate should fold on a millisecond time scale or less and form much faster than the native state. Other factors that may lead to the slow folding of the native state and the accumulation of the intermediate before the rate-limiting transition state are also discussed. JF - Journal of Molecular Biology AU - Zhou, Z AU - Feng, H AU - Ghirlando, R AU - Bai, Y AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, yawen@helix.nih.gov Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 531 EP - 539 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 384 IS - 2 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; ASFA 1: Biological Sciences & Living Resources KW - Protein folding KW - Protein engineering KW - Biochemistry KW - Ribonuclease H KW - Microorganisms KW - N.M.R. KW - Thermus thermophilus KW - Q1 08206:Physiology, biochemistry, biophysics KW - J 02320:Cell Biology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19805151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=The+High-Resolution+NMR+Structure+of+the+Early+Folding+Intermediate+of+the+Thermus+thermophilus+Ribonuclease+H&rft.au=Zhou%2C+Z%3BFeng%2C+H%3BGhirlando%2C+R%3BBai%2C+Y&rft.aulast=Zhou&rft.aufirst=Z&rft.date=2008-12-12&rft.volume=384&rft.issue=2&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2008.09.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Biochemistry; Microorganisms; Protein engineering; Protein folding; Ribonuclease H; N.M.R.; Thermus thermophilus DO - http://dx.doi.org/10.1016/j.jmb.2008.09.044 ER - TY - JOUR T1 - Urethane and N-nitrosodiethylamine are mutagenic for the Syrian hamster fetus. AN - 69827926; 18755288 AB - Urethane and N-nitrosodiethylamine are soluble environmental carcinogens that initiate tumors transplacentally, but have a mixed history of effectiveness in mutagenesis assays in vitro or in vivo with adult rodents. To test for their transplacental mutagenicity, Syrian hamster fetuses at 12 days in gestation were exposed transplacentally to urethane or N-nitrosodiethylamine at 0.5 or 1.0 mM/kg. The fetal cells were isolated on day 13 of gestation and tested for diphtheria toxin resistance as a mutation marker. Both compounds were significantly mutagenic, at both doses, causing 6- to 20-fold increases in mutations compared with controls. Compared with N-nitrosodiethylamine, urethane was somewhat more effective as a mutagen with a more marked dose-response. These results are consistent with mutagenesis as part of the mechanism of transplacental carcinogenicity of urethane and N-nitrosodiethylamine. JF - Mutation research AU - Donovan, Paul J AU - Smith, George T AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538, Room 205 NCI-Frederick, Frederick, MD 21702-1201, USA. donovapa@mail.nih.gov Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 SP - 160 EP - 163 VL - 657 IS - 2 SN - 0027-5107, 0027-5107 KW - Alkylating Agents KW - 0 KW - Carcinogens KW - Mutagens KW - Urethane KW - 3IN71E75Z5 KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Index Medicus KW - Animals KW - Mutation KW - Female KW - Pregnancy KW - Cricetinae KW - Diethylnitrosamine -- toxicity KW - Fetus -- drug effects KW - Carcinogens -- toxicity KW - Mutagens -- toxicity KW - Alkylating Agents -- toxicity KW - Urethane -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69827926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Urethane+and+N-nitrosodiethylamine+are+mutagenic+for+the+Syrian+hamster+fetus.&rft.au=Donovan%2C+Paul+J%3BSmith%2C+George+T&rft.aulast=Donovan&rft.aufirst=Paul&rft.date=2008-12-08&rft.volume=657&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2008.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2008.07.011 ER - TY - CPAPER T1 - An Improved Estimator of Variance Explained in the Presence of Noise T2 - Twenty-Second Annual Conference on Neural Information Processing Systems (NIPS 2008) AN - 41973843; 5130017 JF - Twenty-Second Annual Conference on Neural Information Processing Systems (NIPS 2008) AU - Haefner, Ralf AU - Cumming, Bruce Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41973843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Twenty-Second+Annual+Conference+on+Neural+Information+Processing+Systems+%28NIPS+2008%29&rft.atitle=An+Improved+Estimator+of+Variance+Explained+in+the+Presence+of+Noise&rft.au=Haefner%2C+Ralf%3BCumming%2C+Bruce&rft.aulast=Haefner&rft.aufirst=Ralf&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Twenty-Second+Annual+Conference+on+Neural+Information+Processing+Systems+%28NIPS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://nips.cc/Conferences/2008/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Collaborative Learning by Boosting in Distributed Environments T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41721764; 4987087 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Wang, Shijun AU - Zhang, Changshui Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41721764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Collaborative+Learning+by+Boosting+in+Distributed+Environments&rft.au=Wang%2C+Shijun%3BZhang%2C+Changshui&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Anatomical Landmarks in Human Colon from Computed Tomographic Colonography Images T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41706111; 4986926 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Chowdhury, Ananda AU - Yao, Jianhua AU - Van Uitert, Robert AU - Linguraru, Marius AU - Summers, Ronald Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Colon KW - Computed tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41706111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Detection+of+Anatomical+Landmarks+in+Human+Colon+from+Computed+Tomographic+Colonography+Images&rft.au=Chowdhury%2C+Ananda%3BYao%2C+Jianhua%3BVan+Uitert%2C+Robert%3BLinguraru%2C+Marius%3BSummers%2C+Ronald&rft.aulast=Chowdhury&rft.aufirst=Ananda&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Matching Colonic Polyps from Prone and Supine CT Colonography Scans Based on Statistical Curvature Information T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41705364; 4986949 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Wang, Shijun AU - Yao, Jianhua AU - Summers, Ronald Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Polyps KW - Statistics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41705364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Matching+Colonic+Polyps+from+Prone+and+Supine+CT+Colonography+Scans+Based+on+Statistical+Curvature+Information&rft.au=Wang%2C+Shijun%3BYao%2C+Jianhua%3BSummers%2C+Ronald&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cervicographic Image Retrieval by Spatial Similarity of Lesions T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41656636; 4987455 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Xue, Zhiyun AU - Long, L AU - Antani, Sameer AU - Thoma, George AU - Jeronimo, Jose Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Lesions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41656636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Cervicographic+Image+Retrieval+by+Spatial+Similarity+of+Lesions&rft.au=Xue%2C+Zhiyun%3BLong%2C+L%3BAntani%2C+Sameer%3BThoma%2C+George%3BJeronimo%2C+Jose&rft.aulast=Xue&rft.aufirst=Zhiyun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biological Functions of Membrane-Type Matrix Metalloproteinases T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41899422; 5091696 JF - 2008 Meeting of the American Society for Matrix Biology AU - Holmbeck, Kenn Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Matrix metalloproteinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Biological+Functions+of+Membrane-Type+Matrix+Metalloproteinases&rft.au=Holmbeck%2C+Kenn&rft.aulast=Holmbeck&rft.aufirst=Kenn&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Early Inflammatory Response to Bites of Leishmania Major Infected Phlebotomus Duboscqi Sand Flies in NaiVe and Pre -Exposed Mice T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41897139; 5079979 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Teixeira, Clarissa AU - Oliveira, Luis AU - Gomes, Regis AU - Elnaiem, Dia AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Bites KW - Mice KW - Sand KW - Inflammation KW - Leishmania major KW - Phlebotomus duboscqi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Characterization+of+the+Early+Inflammatory+Response+to+Bites+of+Leishmania+Major+Infected+Phlebotomus+Duboscqi+Sand+Flies+in+NaiVe+and+Pre+-Exposed+Mice&rft.au=Teixeira%2C+Clarissa%3BOliveira%2C+Luis%3BGomes%2C+Regis%3BElnaiem%2C+Dia%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Teixeira&rft.aufirst=Clarissa&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discovery of Leishmania Parasite -Sandfly Interaction Targets for Transmission -Blocking and /or Sandfly -Killing Vaccines T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41896637; 5080273 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Vaccines KW - Disease control KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41896637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Discovery+of+Leishmania+Parasite+-Sandfly+Interaction+Targets+for+Transmission+-Blocking+and+%2For+Sandfly+-Killing+Vaccines&rft.au=Valenzuela%2C+Jesus&rft.aulast=Valenzuela&rft.aufirst=Jesus&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutual Stabilization of P3H1 and CRTAP in ER Modification Complex T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41888893; 5091903 JF - 2008 Meeting of the American Society for Matrix Biology AU - Chang, W AU - Barnes, A AU - Cabral, W AU - Marini, J Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Stabilizing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Mutual+Stabilization+of+P3H1+and+CRTAP+in+ER+Modification+Complex&rft.au=Chang%2C+W%3BBarnes%2C+A%3BCabral%2C+W%3BMarini%2C+J&rft.aulast=Chang&rft.aufirst=W&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Basement Membrane Remodeling During Branching Morphogenesis: The Dynamic Interplay of Proteolysis and Proliferation T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41888867; 5091735 JF - 2008 Meeting of the American Society for Matrix Biology AU - Hoffman, Matthew Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Membranes KW - Proteolysis KW - Morphogenesis KW - Basement membranes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Basement+Membrane+Remodeling+During+Branching+Morphogenesis%3A+The+Dynamic+Interplay+of+Proteolysis+and+Proliferation&rft.au=Hoffman%2C+Matthew&rft.aulast=Hoffman&rft.aufirst=Matthew&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Confocal Microscopy Study of Decorin Binding to Collagen Fibrils T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41885384; 5091897 JF - 2008 Meeting of the American Society for Matrix Biology AU - Makareeva, Elena AU - Sutter, Mary AU - DeRidder, Angela AU - Forlino, Antonella AU - Rossi, Antonio AU - Tenni, Ruggero AU - Leikin, Sergey Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Confocal microscopy KW - Decorin KW - Collagen KW - Fibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41885384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Confocal+Microscopy+Study+of+Decorin+Binding+to+Collagen+Fibrils&rft.au=Makareeva%2C+Elena%3BSutter%2C+Mary%3BDeRidder%2C+Angela%3BForlino%2C+Antonella%3BRossi%2C+Antonio%3BTenni%2C+Ruggero%3BLeikin%2C+Sergey&rft.aulast=Makareeva&rft.aufirst=Elena&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Institutes of Health /Fogarty International Center Support to Build Research Capacity T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41884910; 5079190 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sina, Barbara Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41884910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=National+Institutes+of+Health+%2FFogarty+International+Center+Support+to+Build+Research+Capacity&rft.au=Sina%2C+Barbara&rft.aulast=Sina&rft.aufirst=Barbara&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct OI Phenotype Caused by COL1 C-proteinase Site Mutations T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41877171; 5091868 JF - 2008 Meeting of the American Society for Matrix Biology AU - Barnes, A AU - Lindahl, K AU - Whyte, M AU - Hefferan, T AU - Rubin, C-J AU - Kindmark, A AU - McAlister, W AU - Mumm, S AU - Ljunggren, O AU - Marini, J Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mutation KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Distinct+OI+Phenotype+Caused+by+COL1+C-proteinase+Site+Mutations&rft.au=Barnes%2C+A%3BLindahl%2C+K%3BWhyte%2C+M%3BHefferan%2C+T%3BRubin%2C+C-J%3BKindmark%2C+A%3BMcAlister%2C+W%3BMumm%2C+S%3BLjunggren%2C+O%3BMarini%2C+J&rft.aulast=Barnes&rft.aufirst=A&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DMP1 Isoforms Promote Differential Cell Attachment and Migration T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41873107; 5091703 JF - 2008 Meeting of the American Society for Matrix Biology AU - von Marschall, Zofia Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Migration KW - Cell adhesion KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41873107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=DMP1+Isoforms+Promote+Differential+Cell+Attachment+and+Migration&rft.au=von+Marschall%2C+Zofia&rft.aulast=von+Marschall&rft.aufirst=Zofia&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building Research and Human Capacity One Link at a Time : the National Library of Medicine 's International Information Interventions T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872876; 5080194 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Royall, Julia Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Building+Research+and+Human+Capacity+One+Link+at+a+Time+%3A+the+National+Library+of+Medicine+%27s+International+Information+Interventions&rft.au=Royall%2C+Julia&rft.aulast=Royall&rft.aufirst=Julia&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of Invasive Long Lived Plasmodium Falciparum Merozoites by Cell Sieving T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872465; 5079893 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Narum, David AU - Haynes, J AU - Moch, J AU - Dutta, Sheetij Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Merozoites KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Isolation+of+Invasive+Long+Lived+Plasmodium+Falciparum+Merozoites+by+Cell+Sieving&rft.au=Narum%2C+David%3BHaynes%2C+J%3BMoch%2C+J%3BDutta%2C+Sheetij&rft.aulast=Narum&rft.aufirst=David&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post -treatment reactions in loiasis : looking towards the future T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872284; 5079845 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Klion, Amy Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Post+-treatment+reactions+in+loiasis+%3A+looking+towards+the+future&rft.au=Klion%2C+Amy&rft.aulast=Klion&rft.aufirst=Amy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complexity of the Tick Salivary Gland Transcriptome and Proteome T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41871969; 5079779 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ribeiro, Jose Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Gene expression KW - Salivary gland KW - Glands KW - Ixodidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41871969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Complexity+of+the+Tick+Salivary+Gland+Transcriptome+and+Proteome&rft.au=Ribeiro%2C+Jose&rft.aulast=Ribeiro&rft.aufirst=Jose&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thrombospondin-1 Regulates Blood Pressure and Cardiac Response T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41871555; 5091823 JF - 2008 Meeting of the American Society for Matrix Biology AU - Isenberg, Jeff AU - Qin, Yan AU - Despres, Daryl AU - Bandle, Russell AU - Schnermann, Jurgen AU - Frazier, William AU - Roberts, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Thrombospondin KW - Blood pressure KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41871555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Thrombospondin-1+Regulates+Blood+Pressure+and+Cardiac+Response&rft.au=Isenberg%2C+Jeff%3BQin%2C+Yan%3BDespres%2C+Daryl%3BBandle%2C+Russell%3BSchnermann%2C+Jurgen%3BFrazier%2C+William%3BRoberts%2C+David&rft.aulast=Isenberg&rft.aufirst=Jeff&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Anti -ama1 Antibodies Induced by ama1-c2, a Three -Allele Combination Vaccine T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41868786; 5078727 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Murray, Sara AU - Zhou, Hong AU - Aebig, Joan AU - Lambert, Lynn AU - Martin, Laura AU - Miller, Louis AU - Long, Carole AU - Miura, Kazutoyo Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Antibodies KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Characterization+of+Anti+-ama1+Antibodies+Induced+by+ama1-c2%2C+a+Three+-Allele+Combination+Vaccine&rft.au=Murray%2C+Sara%3BZhou%2C+Hong%3BAebig%2C+Joan%3BLambert%2C+Lynn%3BMartin%2C+Laura%3BMiller%2C+Louis%3BLong%2C+Carole%3BMiura%2C+Kazutoyo&rft.aulast=Murray&rft.aufirst=Sara&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of a Serine Protease from A. Gambiae in Plasmodium Development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41868573; 5079614 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rodrigues, Janneth AU - Abban, Ekua AU - Ortega, Corrie AU - Molina-Cruz, Alvaro AU - Barillas Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Serine proteinase KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Role+of+a+Serine+Protease+from+A.+Gambiae+in+Plasmodium+Development&rft.au=Rodrigues%2C+Janneth%3BAbban%2C+Ekua%3BOrtega%2C+Corrie%3BMolina-Cruz%2C+Alvaro%3BBarillas+Mury%2C+Carolina&rft.aulast=Rodrigues&rft.aufirst=Janneth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro Assessment of Taenia crassiceps Motility and its Application to the Study of Anthelmintic Treatment in Neurocysticercosis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41867556; 5078802 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Scott, Erick AU - Kabat, Juraj AU - Schwartz, Owen AU - Nash, Theodore AU - Mahanty, Siddhartha Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Motility KW - Cysticercosis KW - Taenia KW - Taenia crassiceps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=In+vitro+Assessment+of+Taenia+crassiceps+Motility+and+its+Application+to+the+Study+of+Anthelmintic+Treatment+in+Neurocysticercosis&rft.au=Scott%2C+Erick%3BKabat%2C+Juraj%3BSchwartz%2C+Owen%3BNash%2C+Theodore%3BMahanty%2C+Siddhartha&rft.aulast=Scott&rft.aufirst=Erick&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profiling protective humoral immune responses to Plasmodium falciparum by protein microarray in a longitudinal study in Mali T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41867131; 5079544 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Crompton, Peter AU - Kayala, Matt AU - Traore, Boubacar AU - Weiss, Greta AU - Burk, Chad AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Doumbo, Safiatou AU - Miller, Louis AU - Doumbo, Ogobara AU - Doolan, Denise AU - Baldi, Pierre AU - Felgner, Philip AU - Pierce, Susan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Longitudinal studies KW - Protein arrays KW - Immune response (humoral) KW - Parasites KW - Profiling KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Profiling+protective+humoral+immune+responses+to+Plasmodium+falciparum+by+protein+microarray+in+a+longitudinal+study+in+Mali&rft.au=Crompton%2C+Peter%3BKayala%2C+Matt%3BTraore%2C+Boubacar%3BWeiss%2C+Greta%3BBurk%2C+Chad%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BDoumbo%2C+Safiatou%3BMiller%2C+Louis%3BDoumbo%2C+Ogobara%3BDoolan%2C+Denise%3BBaldi%2C+Pierre%3BFelgner%2C+Philip%3BPierce%2C+Susan&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The impact of access to primary health care on the incidence of clinical malaria in children T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41861292; 5079540 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - O'Meara, Wendy AU - Noor, Abdisalan AU - Tsofa, Benjamin AU - McKenzie, F AU - Marsh, Kevin Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Children KW - Malaria KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+impact+of+access+to+primary+health+care+on+the+incidence+of+clinical+malaria+in+children&rft.au=O%27Meara%2C+Wendy%3BNoor%2C+Abdisalan%3BTsofa%2C+Benjamin%3BMcKenzie%2C+F%3BMarsh%2C+Kevin&rft.aulast=O%27Meara&rft.aufirst=Wendy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and molecular cataloging of hemocyte specific immune genes from malaria vector A. gambiae T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41860759; 5080128 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Dixit, Rajnikant AU - Kumar, Sanjeev AU - Gupta, Lalita AU - Molina-Cruz, Alvaro AU - Rodrigues, Janneth AU - Valenzuela, Jesus AU - Ribeiro, Jose AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Malaria KW - Vectors KW - Hemocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Identification+and+molecular+cataloging+of+hemocyte+specific+immune+genes+from+malaria+vector+A.+gambiae&rft.au=Dixit%2C+Rajnikant%3BKumar%2C+Sanjeev%3BGupta%2C+Lalita%3BMolina-Cruz%2C+Alvaro%3BRodrigues%2C+Janneth%3BValenzuela%2C+Jesus%3BRibeiro%2C+Jose%3BBarillas-Mury%2C+Carolina&rft.aulast=Dixit&rft.aufirst=Rajnikant&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Does Plasmodium Evade the Mosquito 'S Immune System ? T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41860423; 5079240 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immune system KW - Aquatic insects KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=How+Does+Plasmodium+Evade+the+Mosquito+%27S+Immune+System+%3F&rft.au=Barillas-Mury%2C+Carolina&rft.aulast=Barillas-Mury&rft.aufirst=Carolina&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MSCs create a TIMP-rich, matrix-protective local environment T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41859176; 5091830 JF - 2008 Meeting of the American Society for Matrix Biology AU - Lozito, Thomas AU - White, Cassie AU - Kuo, Catherine AU - Taboas, Juan AU - Tuan, Rocky Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=MSCs+create+a+TIMP-rich%2C+matrix-protective+local+environment&rft.au=Lozito%2C+Thomas%3BWhite%2C+Cassie%3BKuo%2C+Catherine%3BTaboas%2C+Juan%3BTuan%2C+Rocky&rft.aulast=Lozito&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ECMPs act as centers of MMP activation and matrix remodeling T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41859135; 5091829 JF - 2008 Meeting of the American Society for Matrix Biology AU - Lozito, Thomas AU - White, Cassie AU - Kuo, Catherine AU - Taboas, Juan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=ECMPs+act+as+centers+of+MMP+activation+and+matrix+remodeling&rft.au=Lozito%2C+Thomas%3BWhite%2C+Cassie%3BKuo%2C+Catherine%3BTaboas%2C+Juan&rft.aulast=Lozito&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Humans from an endemic area of cutaneous leishmaniasis in Mali produce IFN-gamma to sand fly salivary proteins T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857936; 5079924 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Oliveira, Fabiano AU - Gomes, Regis AU - Teixeira, Clarissa AU - Faye, Ousmane AU - Traore, Pierre AU - Diarra, Souleymane AU - Anderson, Jeniffer AU - Dia-Eldin, Elnaiem AU - Samake, Sibiry AU - Traore, Bourama AU - Coulibaly, Cheick AU - Rick, Fairhurst AU - Keita, Somita AU - Doumbia, Seydou AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Sand KW - G-Interferon KW - Cutaneous leishmaniasis KW - Endemic species KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Humans+from+an+endemic+area+of+cutaneous+leishmaniasis+in+Mali+produce+IFN-gamma+to+sand+fly+salivary+proteins&rft.au=Oliveira%2C+Fabiano%3BGomes%2C+Regis%3BTeixeira%2C+Clarissa%3BFaye%2C+Ousmane%3BTraore%2C+Pierre%3BDiarra%2C+Souleymane%3BAnderson%2C+Jeniffer%3BDia-Eldin%2C+Elnaiem%3BSamake%2C+Sibiry%3BTraore%2C+Bourama%3BCoulibaly%2C+Cheick%3BRick%2C+Fairhurst%3BKeita%2C+Somita%3BDoumbia%2C+Seydou%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Oliveira&rft.aufirst=Fabiano&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loa loa : a clinical overview T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857790; 5079842 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Loa+loa+%3A+a+clinical+overview&rft.au=Nutman%2C+Thomas&rft.aulast=Nutman&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lutzomyia longipalpis recombinant salivary yellow -related protein (LJM11) confers protection against leishmania infected sand flies T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857775; 5079976 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Gomes, Regis AU - Oliveira, Fabiano AU - Teixeira, Clarissa AU - Elnaiem, Dia-Eldin AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Sand KW - Recombinants KW - Lutzomyia longipalpis KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Lutzomyia+longipalpis+recombinant+salivary+yellow+-related+protein+%28LJM11%29+confers+protection+against+leishmania+infected+sand+flies&rft.au=Gomes%2C+Regis%3BOliveira%2C+Fabiano%3BTeixeira%2C+Clarissa%3BElnaiem%2C+Dia-Eldin%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Gomes&rft.aufirst=Regis&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Type I collagen homotrimers may alter tissue remodeling T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41857730; 5091809 JF - 2008 Meeting of the American Society for Matrix Biology AU - Han, Sejin AU - Makareeva, Elena AU - McBride, Daniel AU - Phillips, Charlotte AU - Schwarze, Ulrike AU - Pace, James AU - Byers, Peter AU - Visse, Robert AU - Nagase, Hideaki AU - Leikin, Sergey Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Collagen (type I) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Type+I+collagen+homotrimers+may+alter+tissue+remodeling&rft.au=Han%2C+Sejin%3BMakareeva%2C+Elena%3BMcBride%2C+Daniel%3BPhillips%2C+Charlotte%3BSchwarze%2C+Ulrike%3BPace%2C+James%3BByers%2C+Peter%3BVisse%2C+Robert%3BNagase%2C+Hideaki%3BLeikin%2C+Sergey&rft.aulast=Han&rft.aufirst=Sejin&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A tep1 Mediated Response Is Required but Not Sufficient for Melanization of Plasmodium Falciprum in the Anopheles Gambiae Midgut T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857482; 5080283 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Molina-Cruz, Alvaro AU - Ortega, Corrie AU - DeJong, Randall AU - Rodrigues, Janneth AU - Jaramillo-Gutierrez, Giovanna AU - Abban, Ekua AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Midgut KW - Melanization KW - Aquatic insects KW - Plasmodium KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+tep1+Mediated+Response+Is+Required+but+Not+Sufficient+for+Melanization+of+Plasmodium+Falciprum+in+the+Anopheles+Gambiae+Midgut&rft.au=Molina-Cruz%2C+Alvaro%3BOrtega%2C+Corrie%3BDeJong%2C+Randall%3BRodrigues%2C+Janneth%3BJaramillo-Gutierrez%2C+Giovanna%3BAbban%2C+Ekua%3BBarillas-Mury%2C+Carolina&rft.aulast=Molina-Cruz&rft.aufirst=Alvaro&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing the correlation between Growth Inhibition activity and malaria risk in a longitudinal study in Mali T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857209; 5079543 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Crompton, Peter AU - Miura, Kazutoyo AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Weiss, Greta AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Huang, Chiung-Yu AU - Doumbo, Ogobara AU - Miller, Louis AU - Long, Carole AU - Pierce, Susan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Longitudinal studies KW - Malaria KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Assessing+the+correlation+between+Growth+Inhibition+activity+and+malaria+risk+in+a+longitudinal+study+in+Mali&rft.au=Crompton%2C+Peter%3BMiura%2C+Kazutoyo%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BWeiss%2C+Greta%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BHuang%2C+Chiung-Yu%3BDoumbo%2C+Ogobara%3BMiller%2C+Louis%3BLong%2C+Carole%3BPierce%2C+Susan&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracellular Matrix Control of Stem Cell Niches T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41856585; 5091682 JF - 2008 Meeting of the American Society for Matrix Biology AU - Young, Marian Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Stem cells KW - Niches KW - Extracellular matrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Extracellular+Matrix+Control+of+Stem+Cell+Niches&rft.au=Young%2C+Marian&rft.aulast=Young&rft.aufirst=Marian&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neutrophils Are the Predominant Initial Host Cell for Leishmania Major and Are Essential for the Establishment of Sand Fly Transmitted Infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41856528; 5080344 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Peters, Nathan AU - Egen, Jackson AU - Secundino, Naglia AU - Debrabant, Alain AU - Kimblin, Nicola AU - Kamhawi, Shaden AU - Lawyer, Phillip AU - Germain, Ronald AU - Sacks, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Sand KW - Leukocytes (neutrophilic) KW - Leishmania major KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Neutrophils+Are+the+Predominant+Initial+Host+Cell+for+Leishmania+Major+and+Are+Essential+for+the+Establishment+of+Sand+Fly+Transmitted+Infection&rft.au=Peters%2C+Nathan%3BEgen%2C+Jackson%3BSecundino%2C+Naglia%3BDebrabant%2C+Alain%3BKimblin%2C+Nicola%3BKamhawi%2C+Shaden%3BLawyer%2C+Phillip%3BGermain%2C+Ronald%3BSacks%2C+David&rft.aulast=Peters&rft.aufirst=Nathan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide Depletion and Endothelial Dysfunction in Children with Malaria and Marked Anemia T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41856365; 5080320 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Janka, Jacqueline AU - Koita, Ousmane AU - Josepha, Maya AU - Traore, Broulaye AU - Mzayek, Fawaz AU - Sangare, Lansana AU - Cisse, Ousmane AU - Mendelsohn, Laurel AU - Wang, Xunde AU - Masur, Henry AU - Gladwin, Mark AU - Krogstad, Donald Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Anemia KW - Children KW - Malaria KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Nitric+Oxide+Depletion+and+Endothelial+Dysfunction+in+Children+with+Malaria+and+Marked+Anemia&rft.au=Janka%2C+Jacqueline%3BKoita%2C+Ousmane%3BJosepha%2C+Maya%3BTraore%2C+Broulaye%3BMzayek%2C+Fawaz%3BSangare%2C+Lansana%3BCisse%2C+Ousmane%3BMendelsohn%2C+Laurel%3BWang%2C+Xunde%3BMasur%2C+Henry%3BGladwin%2C+Mark%3BKrogstad%2C+Donald&rft.aulast=Janka&rft.aufirst=Jacqueline&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of human H5N1 disease in SEA with emphasis on epidemiology and clinical outcomes in H5N1 T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855255; 5079876 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sedyaningsih, Endang Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Reviews KW - Epidemiology KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Overview+of+human+H5N1+disease+in+SEA+with+emphasis+on+epidemiology+and+clinical+outcomes+in+H5N1&rft.au=Sedyaningsih%2C+Endang&rft.aulast=Sedyaningsih&rft.aufirst=Endang&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of IgM capture ELISA assays for the detection anti -JEV IgM antibodies in cerebrospinal fluid samples T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855101; 5079828 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Vasanthapuram, Ravi AU - Robinson, Jamie AU - Russell, Brandy AU - Desai, Anita AU - Ramamurty, Nalini AU - Featherstone, David AU - Johnson, Barbara Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immunoglobulin M KW - Cerebrospinal fluid KW - ELISA KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Evaluation+of+IgM+capture+ELISA+assays+for+the+detection+anti+-JEV+IgM+antibodies+in+cerebrospinal+fluid+samples&rft.au=Vasanthapuram%2C+Ravi%3BRobinson%2C+Jamie%3BRussell%2C+Brandy%3BDesai%2C+Anita%3BRamamurty%2C+Nalini%3BFeatherstone%2C+David%3BJohnson%2C+Barbara&rft.aulast=Vasanthapuram&rft.aufirst=Ravi&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The role of human dendritic cells in filarial infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855048; 5079815 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Semnani, Roshanak Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+role+of+human+dendritic+cells+in+filarial+infection&rft.au=Semnani%2C+Roshanak&rft.aulast=Semnani&rft.aufirst=Roshanak&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of miRNAs that regulate epithelial morphogenesis during submandibular gland development T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41853541; 5091936 JF - 2008 Meeting of the American Society for Matrix Biology AU - Rebustini, I AU - Reynolds, A AU - Hoffman, M Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - MiRNA KW - Submandibular gland KW - Morphogenesis KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Identification+of+miRNAs+that+regulate+epithelial+morphogenesis+during+submandibular+gland+development&rft.au=Rebustini%2C+I%3BReynolds%2C+A%3BHoffman%2C+M&rft.aulast=Rebustini&rft.aufirst=I&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/2008%20ASMB%20Addendum.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Phase 1 study of the blood stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41852912; 5079565 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ellis, Ruth AU - Martin, Laura AU - Pierce, Mark AU - Miura, Kazutoyo AU - Mullen, Gregory AU - Fay, Michael AU - Long, Carole AU - Shaffer, Donna AU - Saul, Allan AU - Miller, Louis AU - Durbin, Anna Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Blood KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Phase+1+study+of+the+blood+stage+malaria+vaccine+candidate+AMA1-C1%2FAlhydrogel+with+CPG+7909%2C+using+two+different+formulations+and+dosing+intervals&rft.au=Ellis%2C+Ruth%3BMartin%2C+Laura%3BPierce%2C+Mark%3BMiura%2C+Kazutoyo%3BMullen%2C+Gregory%3BFay%2C+Michael%3BLong%2C+Carole%3BShaffer%2C+Donna%3BSaul%2C+Allan%3BMiller%2C+Louis%3BDurbin%2C+Anna&rft.aulast=Ellis&rft.aufirst=Ruth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Filarial lymphatic pathology is characterized by augmented pro -inflammatory cytokine production in response to TLR2 and TLR9 ligands T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41852677; 5079275 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Babu, Subash AU - Bhat, Sajid AU - Kumar, Pavan AU - Kolappan, C AU - Kumaraswami, V AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Pathology KW - Toll-like receptors KW - TLR2 protein KW - Cytokines KW - TLR9 protein KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Filarial+lymphatic+pathology+is+characterized+by+augmented+pro+-inflammatory+cytokine+production+in+response+to+TLR2+and+TLR9+ligands&rft.au=Babu%2C+Subash%3BBhat%2C+Sajid%3BKumar%2C+Pavan%3BKolappan%2C+C%3BKumaraswami%2C+V%3BNutman%2C+Thomas&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Alum Formulation Immunoassay (Dafia): An Immunofluorescent Assay That Directly Determines the Content , Identity and Integrity of Antigens Formulated on Alhydrogel T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851905; 5080105 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Zhu, Daming AU - Huang, Shuhui AU - Gebregeorgis, Elizabeth AU - McClellan, Holly AU - Miller, Louis AU - Saul, Allan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immunoassays KW - Aluminum sulfate KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Direct+Alum+Formulation+Immunoassay+%28Dafia%29%3A+An+Immunofluorescent+Assay+That+Directly+Determines+the+Content+%2C+Identity+and+Integrity+of+Antigens+Formulated+on+Alhydrogel&rft.au=Zhu%2C+Daming%3BHuang%2C+Shuhui%3BGebregeorgis%2C+Elizabeth%3BMcClellan%2C+Holly%3BMiller%2C+Louis%3BSaul%2C+Allan&rft.aulast=Zhu&rft.aufirst=Daming&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions of Yersinia Pestis with Its Flea Vector That Underlie Stable Plague Transmission Cycles T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851447; 5080267 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Hinnebusch, B Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Disease transmission KW - Vectors KW - Plague KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Interactions+of+Yersinia+Pestis+with+Its+Flea+Vector+That+Underlie+Stable+Plague+Transmission+Cycles&rft.au=Hinnebusch%2C+B&rft.aulast=Hinnebusch&rft.aufirst=B&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Phase 1 Trial of the Malaria Transmission Blocking Vaccine Candidates Pfs 25 and Pvs 25 formulated with Montanide ISA 51 T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851443; 5078780 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ellis, Ruth AU - Wu, Yimin AU - Shaffer, Donna AU - Fontes, Erica AU - Malkin, Elissa AU - Mahanty, Siddhartha AU - Fay, Michael AU - Narum, David AU - Rausch, Kelly AU - Miles, Aaron AU - Aebig, Joan AU - Orcutt, Andrew AU - Muratova, Olga AU - Song, Guanhong AU - Lambert, Lynn AU - Zhu, Daming AU - Miura, Kazutoyo AU - Long, Carole AU - Saul, Allan AU - Miller, Louis AU - Durbin, Anna Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Disease transmission KW - Malaria KW - Fish diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Phase+1+Trial+of+the+Malaria+Transmission+Blocking+Vaccine+Candidates+Pfs+25+and+Pvs+25+formulated+with+Montanide+ISA+51&rft.au=Ellis%2C+Ruth%3BWu%2C+Yimin%3BShaffer%2C+Donna%3BFontes%2C+Erica%3BMalkin%2C+Elissa%3BMahanty%2C+Siddhartha%3BFay%2C+Michael%3BNarum%2C+David%3BRausch%2C+Kelly%3BMiles%2C+Aaron%3BAebig%2C+Joan%3BOrcutt%2C+Andrew%3BMuratova%2C+Olga%3BSong%2C+Guanhong%3BLambert%2C+Lynn%3BZhu%2C+Daming%3BMiura%2C+Kazutoyo%3BLong%2C+Carole%3BSaul%2C+Allan%3BMiller%2C+Louis%3BDurbin%2C+Anna&rft.aulast=Ellis&rft.aufirst=Ruth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatio-temporal ordering of a Chagas disease vector elimination campaign T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41850661; 5079730 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Levy, Michael AU - Malaga, Fernando AU - Cornejo del Carpio, Juan AU - McKenzie, Ellis AU - Plotkin, Joshua Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Chagas' disease KW - Disease transmission KW - Hosts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41850661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Spatio-temporal+ordering+of+a+Chagas+disease+vector+elimination+campaign&rft.au=Levy%2C+Michael%3BMalaga%2C+Fernando%3BCornejo+del+Carpio%2C+Juan%3BMcKenzie%2C+Ellis%3BPlotkin%2C+Joshua&rft.aulast=Levy&rft.aufirst=Michael&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation technologies for malaria vaccine development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41849196; 5079699 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Long, Carole Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Technology KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Evaluation+technologies+for+malaria+vaccine+development&rft.au=Long%2C+Carole&rft.aulast=Long&rft.aufirst=Carole&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Frequency of Drug Resistance Mutations in dhfr, dhps , and pfcrt, on the Pacific Coast of Peru T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41849029; 5080084 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Arrospide, Nancy AU - Gutierrez, Sonia AU - Marquino, Wilmer AU - Ruebush, Trent Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Peru KW - Pacific KW - Mutation KW - Coastal zone KW - Drug resistance KW - Dihydrofolate reductase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+Frequency+of+Drug+Resistance+Mutations+in+dhfr%2C+dhps+%2C+and+pfcrt%2C+on+the+Pacific+Coast+of+Peru&rft.au=Arrospide%2C+Nancy%3BGutierrez%2C+Sonia%3BMarquino%2C+Wilmer%3BRuebush%2C+Trent&rft.aulast=Arrospide&rft.aufirst=Nancy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anti -Apical Membrane Antigen 1 Igg Is More Effective in Inhibiting Plasmodium Falciparum Growth as Measured by in Vitro Growth Inhibition Assay than Anti -Merozoite Surface Protein 1 42 Igg T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41848731; 5079575 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Miura, Kazutoyo AU - Zhou, Hong AU - Diouf, Ababacar AU - Moretz, Samuel AU - Miller, Louis AU - Martin, Laura AU - Mullen, Gregory AU - Long, Carole Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Membranes KW - Immunoglobulin G KW - Growth KW - Parasites KW - Antigens KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Anti+-Apical+Membrane+Antigen+1+Igg+Is+More+Effective+in+Inhibiting+Plasmodium+Falciparum+Growth+as+Measured+by+in+Vitro+Growth+Inhibition+Assay+than+Anti+-Merozoite+Surface+Protein+1+42+Igg&rft.au=Miura%2C+Kazutoyo%3BZhou%2C+Hong%3BDiouf%2C+Ababacar%3BMoretz%2C+Samuel%3BMiller%2C+Louis%3BMartin%2C+Laura%3BMullen%2C+Gregory%3BLong%2C+Carole&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative analysis of malaria vaccine candidate AMA1-C1/Alhydrogel with the addition of unique CpG sequences T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41848654; 5079568 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rausch, Kelly AU - Ramineni, Bhanumati AU - Lambert, Lynn AU - Miura, Kazutoyo AU - Barnafo, Emma AU - Long, Carole AU - Miller, Louis AU - Martin, Laura Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Comparative+analysis+of+malaria+vaccine+candidate+AMA1-C1%2FAlhydrogel+with+the+addition+of+unique+CpG+sequences&rft.au=Rausch%2C+Kelly%3BRamineni%2C+Bhanumati%3BLambert%2C+Lynn%3BMiura%2C+Kazutoyo%3BBarnafo%2C+Emma%3BLong%2C+Carole%3BMiller%2C+Louis%3BMartin%2C+Laura&rft.aulast=Rausch&rft.aufirst=Kelly&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of TRAIL- and TNF-?-dependent apoptotic cell death in human monocyte -derived dendritic cells by Brugia malayi T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41847988; 5079273 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Semnani, Roshanak AU - Venugopal, Priyanka AU - Mahapatra, Lily AU - Skinner, Jason AU - Meylan, Francoise AU - Chaussabel, Damien AU - Siegel, Richard AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mortality KW - Cell death KW - Dendritic cells KW - Apoptosis KW - Monocytes KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Induction+of+TRAIL-+and+TNF-%3F-dependent+apoptotic+cell+death+in+human+monocyte+-derived+dendritic+cells+by+Brugia+malayi&rft.au=Semnani%2C+Roshanak%3BVenugopal%2C+Priyanka%3BMahapatra%2C+Lily%3BSkinner%2C+Jason%3BMeylan%2C+Francoise%3BChaussabel%2C+Damien%3BSiegel%2C+Richard%3BNutman%2C+Thomas&rft.aulast=Semnani&rft.aufirst=Roshanak&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of acute Plasmodium vivax malaria with PyramaxRG (pyronaridine tetraphosphate /artesunate ) in a controlled Phase III clinical trial T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41847461; 5079923 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Tjitra, Emiliana AU - Ruangweerayut, Ronnatrai AU - Socheat, Duong AU - Valecha, Neena Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Clinical trials KW - Malaria KW - Artesunate KW - Pyronaridine KW - Public health KW - Plasmodium vivax KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Treatment+of+acute+Plasmodium+vivax+malaria+with+PyramaxRG+%28pyronaridine+tetraphosphate+%2Fartesunate+%29+in+a+controlled+Phase+III+clinical+trial&rft.au=Tjitra%2C+Emiliana%3BRuangweerayut%2C+Ronnatrai%3BSocheat%2C+Duong%3BValecha%2C+Neena&rft.aulast=Tjitra&rft.aufirst=Emiliana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in Exposure and Chronicity in Human Filarial Infection Leads to Variable Gene Expression Profiles T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846931; 5078917 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Steel, Cathy AU - Myers, Timothy AU - Su, Qin AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Differences+in+Exposure+and+Chronicity+in+Human+Filarial+Infection+Leads+to+Variable+Gene+Expression+Profiles&rft.au=Steel%2C+Cathy%3BMyers%2C+Timothy%3BSu%2C+Qin%3BNutman%2C+Thomas&rft.aulast=Steel&rft.aufirst=Cathy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Disruption of a Mechanosensitive Ion Channel in Plasmodium Falciparum T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846205; 5078995 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rayavara, Kempaiah AU - Desai, Sanjay Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Channels KW - Ion channels KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Genetic+Disruption+of+a+Mechanosensitive+Ion+Channel+in+Plasmodium+Falciparum&rft.au=Rayavara%2C+Kempaiah%3BDesai%2C+Sanjay&rft.aulast=Rayavara&rft.aufirst=Kempaiah&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Neonatal Murine Model of Enteroaggregative Escherichia coli Infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846197; 5078878 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Cabal, Ace AU - Roche, James AU - Sevilleja, Jesus AU - Nataro, James AU - Guerrant, Richard Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Neonates KW - Animal models KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Novel+Neonatal+Murine+Model+of+Enteroaggregative+Escherichia+coli+Infection&rft.au=Cabal%2C+Ace%3BRoche%2C+James%3BSevilleja%2C+Jesus%3BNataro%2C+James%3BGuerrant%2C+Richard&rft.aulast=Cabal&rft.aufirst=Ace&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Carrier Frequency for Recessive OI in West Africans T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41844241; 5091781 JF - 2008 Meeting of the American Society for Matrix Biology AU - Cabral, Wayne AU - Barnes, Aileen AU - Rotimi, Charles AU - Brody, Lawrence AU - Bailey-Wilson, Joan AU - Panny, Susan AU - Chitayat, David AU - Porter, Forbes AU - Marini, Joan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Africa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=High+Carrier+Frequency+for+Recessive+OI+in+West+Africans&rft.au=Cabral%2C+Wayne%3BBarnes%2C+Aileen%3BRotimi%2C+Charles%3BBrody%2C+Lawrence%3BBailey-Wilson%2C+Joan%3BPanny%2C+Susan%3BChitayat%2C+David%3BPorter%2C+Forbes%3BMarini%2C+Joan&rft.aulast=Cabral&rft.aufirst=Wayne&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the barriers preventing successful development of Plasmodium falciparum in Culex mosquitoes T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41840855; 5079693 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Hume, Jen AU - Lehmann, Tovi Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Aquatic insects KW - Parasites KW - Barriers KW - Plasmodium falciparum KW - Culex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41840855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Identification+of+the+barriers+preventing+successful+development+of+Plasmodium+falciparum+in+Culex+mosquitoes&rft.au=Hume%2C+Jen%3BLehmann%2C+Tovi&rft.aulast=Hume&rft.aufirst=Jen&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Drug Resistance Using Plasmodium Falciparum Genetic Crosses T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839959; 5079738 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sa, Juliana AU - Twu, Olivia AU - Hayton, Karen AU - Ringwald, Pascal AU - Wellems, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Drug resistance KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Analysis+of+Drug+Resistance+Using+Plasmodium+Falciparum+Genetic+Crosses&rft.au=Sa%2C+Juliana%3BTwu%2C+Olivia%3BHayton%2C+Karen%3BRingwald%2C+Pascal%3BWellems%2C+Thomas&rft.aulast=Sa&rft.aufirst=Juliana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adjuvants and other immunopotentiators for malaria vaccine development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839752; 5079701 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Seder, Robert Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Adjuvants KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Adjuvants+and+other+immunopotentiators+for+malaria+vaccine+development&rft.au=Seder%2C+Robert&rft.aulast=Seder&rft.aufirst=Robert&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccination with MSP142-C1/Alhydrogel RG generates antigen -specific memory B cells in malaria -naive U.S. adults and the CpG 7909 oligodeoxynucleotide adjuvant enhances this response T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839143; 5079546 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Mircetic, Marko AU - Weiss, Greta AU - Mullen, Gregory AU - Martin, Laura AU - Miller, Louis AU - Pierce, Susan AU - Crompton, Peter Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - USA KW - Malaria KW - Lymphocytes B KW - Memory cells KW - Vaccination KW - Oligonucleotides KW - Immunological memory KW - Adjuvants KW - CpG islands KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Vaccination+with+MSP142-C1%2FAlhydrogel+RG+generates+antigen+-specific+memory+B+cells+in+malaria+-naive+U.S.+adults+and+the+CpG+7909+oligodeoxynucleotide+adjuvant+enhances+this+response&rft.au=Mircetic%2C+Marko%3BWeiss%2C+Greta%3BMullen%2C+Gregory%3BMartin%2C+Laura%3BMiller%2C+Louis%3BPierce%2C+Susan%3BCrompton%2C+Peter&rft.aulast=Mircetic&rft.aufirst=Marko&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Searching for Molecular Determinants of Species Specificity in Sand Flies Colonized by Leishmania Parasites T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41838084; 5079906 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Jochim, Ryan AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Sand KW - Specificity KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Searching+for+Molecular+Determinants+of+Species+Specificity+in+Sand+Flies+Colonized+by+Leishmania+Parasites&rft.au=Jochim%2C+Ryan%3BValenzuela%2C+Jesus&rft.aulast=Jochim&rft.aufirst=Ryan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase 1 Safety and Immunogenicity Trial of a Blood -Stage Malaria Vaccine AMA1-C1/ISA 720 in Australian Adults T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41836562; 5080097 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Arden Pierce, Mark AU - Ellis, Ruth AU - Malkin, Elissa AU - Miura, Kazutoyo AU - Marjason, Joanne AU - Mullen, Gregory AU - Long, Carole AU - Miller, Louis AU - Martin, Laura Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Australia KW - Vaccines KW - Immunogenicity KW - Malaria KW - Blood KW - Fish diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41836562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Phase+1+Safety+and+Immunogenicity+Trial+of+a+Blood+-Stage+Malaria+Vaccine+AMA1-C1%2FISA+720+in+Australian+Adults&rft.au=Arden+Pierce%2C+Mark%3BEllis%2C+Ruth%3BMalkin%2C+Elissa%3BMiura%2C+Kazutoyo%3BMarjason%2C+Joanne%3BMullen%2C+Gregory%3BLong%2C+Carole%3BMiller%2C+Louis%3BMartin%2C+Laura&rft.aulast=Arden+Pierce&rft.aufirst=Mark&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intranasal Administration of a Salmonella -Based Vaccine Expressing cp15 Antigen Confers Protection in Neonatal Mice Challenged with Cryptosporidium Parvum T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41836188; 5079061 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Cabal, Ace AU - Manque, Patricio AU - Lara, Ana AU - Woehlbier, Ute AU - Roche, James AU - Sevilleja, Jesus AU - Rivers-Davis, Andrea AU - Buck, Gregory AU - Guerrant, Richard Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Mice KW - Neonates KW - Intranasal administration KW - Anadromous species KW - Antigens KW - Disease control KW - Salmonella KW - Cryptosporidium parvum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41836188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Intranasal+Administration+of+a+Salmonella+-Based+Vaccine+Expressing+cp15+Antigen+Confers+Protection+in+Neonatal+Mice+Challenged+with+Cryptosporidium+Parvum&rft.au=Cabal%2C+Ace%3BManque%2C+Patricio%3BLara%2C+Ana%3BWoehlbier%2C+Ute%3BRoche%2C+James%3BSevilleja%2C+Jesus%3BRivers-Davis%2C+Andrea%3BBuck%2C+Gregory%3BGuerrant%2C+Richard&rft.aulast=Cabal&rft.aufirst=Ace&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The biochemical and biophysical characterization of an Escherichia coli expressed Plasmodium falciparum circumsporozoite protein (CSP), a leading malaria vaccine candidate T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41835672; 5078726 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Plassmeyer, Matthew AU - MacDonald, Nick AU - Reiter, Karine AU - Shimp, Richard AU - Zhang, Yanling AU - House, Brent AU - Lebowitz, Jack AU - Kotova, Svetlana AU - Jin, Albert AU - Hickman, Merrit AU - Herrera, Raul AU - Uchime, Onyinyechukwu AU - Nguyen, Vu AU - Glen, Jacqueline AU - Miller, Louis AU - Wu, Yimin AU - Narum, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Biochemistry KW - Circumsporozoite protein KW - Parasites KW - Public health KW - Disease control KW - Escherichia coli KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41835672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+biochemical+and+biophysical+characterization+of+an+Escherichia+coli+expressed+Plasmodium+falciparum+circumsporozoite+protein+%28CSP%29%2C+a+leading+malaria+vaccine+candidate&rft.au=Plassmeyer%2C+Matthew%3BMacDonald%2C+Nick%3BReiter%2C+Karine%3BShimp%2C+Richard%3BZhang%2C+Yanling%3BHouse%2C+Brent%3BLebowitz%2C+Jack%3BKotova%2C+Svetlana%3BJin%2C+Albert%3BHickman%2C+Merrit%3BHerrera%2C+Raul%3BUchime%2C+Onyinyechukwu%3BNguyen%2C+Vu%3BGlen%2C+Jacqueline%3BMiller%2C+Louis%3BWu%2C+Yimin%3BNarum%2C+David&rft.aulast=Plassmeyer&rft.aufirst=Matthew&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Roles of Plasmodium Rhomboid 1 in Parasite Development and Malaria Pathogenesis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834909; 5079892 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Srinivasan, Prakash AU - Coppens, Isabelle AU - Jacobs-Lorena, Marcelo Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Malaria KW - Public health KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Distinct+Roles+of+Plasmodium+Rhomboid+1+in+Parasite+Development+and+Malaria+Pathogenesis&rft.au=Srinivasan%2C+Prakash%3BCoppens%2C+Isabelle%3BJacobs-Lorena%2C+Marcelo&rft.aulast=Srinivasan&rft.aufirst=Prakash&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The relationship between malaria transmission intensity , clinical disease and mortality in an area of declining transmission T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834818; 5079851 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - O'Meara, Wendy AU - Mwangi, Tabitha AU - Williams, Thomas AU - McKenzie, F AU - Snow, Robert AU - Marsh, Kevin Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Disease transmission KW - Mortality KW - Malaria KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+relationship+between+malaria+transmission+intensity+%2C+clinical+disease+and+mortality+in+an+area+of+declining+transmission&rft.au=O%27Meara%2C+Wendy%3BMwangi%2C+Tabitha%3BWilliams%2C+Thomas%3BMcKenzie%2C+F%3BSnow%2C+Robert%3BMarsh%2C+Kevin&rft.aulast=O%27Meara&rft.aufirst=Wendy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Production , characterization and immunological evaluation of an Escherichia coli expressed Plasmodium falciparum thrombospondin related apical merozoite protein (PTRAMP), a putative malaria vaccine candidate T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834541; 5080096 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Uchime, Onyinyechukwu AU - Reiter, Karine AU - Nguyen, Vu AU - Glen, Jacqueline AU - Miller, Louis AU - Narum, David AU - Plassmeyer, Matthew Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Thrombospondin KW - Merozoites KW - Parasites KW - Public health KW - Disease control KW - Escherichia coli KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Production+%2C+characterization+and+immunological+evaluation+of+an+Escherichia+coli+expressed+Plasmodium+falciparum+thrombospondin+related+apical+merozoite+protein+%28PTRAMP%29%2C+a+putative+malaria+vaccine+candidate&rft.au=Uchime%2C+Onyinyechukwu%3BReiter%2C+Karine%3BNguyen%2C+Vu%3BGlen%2C+Jacqueline%3BMiller%2C+Louis%3BNarum%2C+David%3BPlassmeyer%2C+Matthew&rft.aulast=Uchime&rft.aufirst=Onyinyechukwu&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early Innate Immune Events in the Skin after Transmission of Yersinia Pestis by Fleas T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834471; 5079747 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Bosio, Christopher AU - Jarrett, Clayton AU - Hinnebusch, B Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Skin KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Early+Innate+Immune+Events+in+the+Skin+after+Transmission+of+Yersinia+Pestis+by+Fleas&rft.au=Bosio%2C+Christopher%3BJarrett%2C+Clayton%3BHinnebusch%2C+B&rft.aulast=Bosio&rft.aufirst=Christopher&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tyrosine Nitration of Proteins by a Putative Nitrate Reductase in Sexual and Asexual P. Falciparum Parasites T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834175; 5079999 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ostera, Graciela AU - Ribeiro, Jose AU - Hume, Jennifer AU - Tokumasu, Fuyuki Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Nitrate reductase KW - Nitration KW - Tyrosine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Tyrosine+Nitration+of+Proteins+by+a+Putative+Nitrate+Reductase+in+Sexual+and+Asexual+P.+Falciparum+Parasites&rft.au=Ostera%2C+Graciela%3BRibeiro%2C+Jose%3BHume%2C+Jennifer%3BTokumasu%2C+Fuyuki&rft.aulast=Ostera&rft.aufirst=Graciela&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A longitudinal study of the acquisition and maintenance of Plasmodium falciparum-specific memory B cells T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41833621; 5079106 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Weiss, Greta AU - Traore, Boubacar AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Mircetic, Marko AU - Ongoiba, Aissata AU - Kayentao, Kassoum AU - Doumbo, Ogobara AU - Pierce, Susan AU - Crompton, Peter Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Longitudinal studies KW - Lymphocytes B KW - Memory cells KW - Immunological memory KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41833621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+longitudinal+study+of+the+acquisition+and+maintenance+of+Plasmodium+falciparum-specific+memory+B+cells&rft.au=Weiss%2C+Greta%3BTraore%2C+Boubacar%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BMircetic%2C+Marko%3BOngoiba%2C+Aissata%3BKayentao%2C+Kassoum%3BDoumbo%2C+Ogobara%3BPierce%2C+Susan%3BCrompton%2C+Peter&rft.aulast=Weiss&rft.aufirst=Greta&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression between Infective and Non -Infective Stage Strongyloides Stercoralis Larvae Revealed by Microarray T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41833595; 5080244 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ramanathan, Roshan AU - Abraham, David AU - Myers, Timothy AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Larvae KW - Gene expression KW - Strongyloides stercoralis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41833595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Differential+Gene+Expression+between+Infective+and+Non+-Infective+Stage+Strongyloides+Stercoralis+Larvae+Revealed+by+Microarray&rft.au=Ramanathan%2C+Roshan%3BAbraham%2C+David%3BMyers%2C+Timothy%3BNutman%2C+Thomas&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Diagnostics and Speciation Guide Choice of Alternative , Short-Course Treatment Regimens for Cutaneous Leishmaniasis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41829358; 5079334 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ramanathan, Roshan AU - Talaat, Kawsar AU - Fedorko, Daniel AU - Mahanty, Siddhartha AU - Nash, Theodore Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Speciation KW - Cutaneous leishmaniasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Molecular+Diagnostics+and+Speciation+Guide+Choice+of+Alternative+%2C+Short-Course+Treatment+Regimens+for+Cutaneous+Leishmaniasis&rft.au=Ramanathan%2C+Roshan%3BTalaat%2C+Kawsar%3BFedorko%2C+Daniel%3BMahanty%2C+Siddhartha%3BNash%2C+Theodore&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Navigating the Nationalational Institutes of Health system T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41829300; 5078816 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Costero, Adriana Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Navigating+the+Nationalational+Institutes+of+Health+system&rft.au=Costero%2C+Adriana&rft.aulast=Costero&rft.aufirst=Adriana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Stoichiometry of Antibody -Mediated Neutralization of West Nile Virus Infection : Factors That Govern Antibody Potency T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41827012; 5079352 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Nelson, Steevenson AU - Mehlhop, Erin AU - Jost, Christiane AU - Johnson, Syd AU - Fremont, Daved AU - Diamond, Michael AU - Pierson, Theodore Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Neutralization KW - Antibodies KW - West Nile virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41827012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+Stoichiometry+of+Antibody+-Mediated+Neutralization+of+West+Nile+Virus+Infection+%3A+Factors+That+Govern+Antibody+Potency&rft.au=Nelson%2C+Steevenson%3BMehlhop%2C+Erin%3BJost%2C+Christiane%3BJohnson%2C+Syd%3BFremont%2C+Daved%3BDiamond%2C+Michael%3BPierson%2C+Theodore&rft.aulast=Nelson&rft.aufirst=Steevenson&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How to Turn Potentiation to Protection : Impact of Immunity to Sand Fly Saliva on Leishmaniasis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41821928; 5080176 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Sand KW - Leishmaniasis KW - Immunity KW - Saliva KW - Potentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41821928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=How+to+Turn+Potentiation+to+Protection+%3A+Impact+of+Immunity+to+Sand+Fly+Saliva+on+Leishmaniasis&rft.au=Valenzuela%2C+Jesus&rft.aulast=Valenzuela&rft.aufirst=Jesus&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patent filarial infection modulates malaria -specific Type 1 cytokine responses in an IL-10 dependent manner in a filaria /malaria co -infected population T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41820354; 5080392 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Metenou, Simon AU - Dembele, Benoit AU - Konate, Siaka AU - Dolo, Housseini AU - Soumaoro, Lamine AU - Diallo, Abdallah AU - Coulibaly, Michel AU - Coulibaly, Siaka AU - Sanogo, Dramane AU - Coulibaly, Yaya AU - Traore, Sekou AU - Klion, Amy AU - Nutman, Thomas AU - Mahanty, Siddhartha Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Malaria KW - Infection KW - Patents KW - Interleukin 10 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41820354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Patent+filarial+infection+modulates+malaria+-specific+Type+1+cytokine+responses+in+an+IL-10+dependent+manner+in+a+filaria+%2Fmalaria+co+-infected+population&rft.au=Metenou%2C+Simon%3BDembele%2C+Benoit%3BKonate%2C+Siaka%3BDolo%2C+Housseini%3BSoumaoro%2C+Lamine%3BDiallo%2C+Abdallah%3BCoulibaly%2C+Michel%3BCoulibaly%2C+Siaka%3BSanogo%2C+Dramane%3BCoulibaly%2C+Yaya%3BTraore%2C+Sekou%3BKlion%2C+Amy%3BNutman%2C+Thomas%3BMahanty%2C+Siddhartha&rft.aulast=Metenou&rft.aufirst=Simon&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Age-Related Changes in Bone Marrow T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41980810; 5123272 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Longo, Dan Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Bone marrow KW - Reviews KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41980810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Overview+of+Age-Related+Changes+in+Bone+Marrow&rft.au=Longo%2C+Dan&rft.aulast=Longo&rft.aufirst=Dan&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of Acute Lymphoblastic Leukemia in Children and Adolescents: Peaks and Pitfalls T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41980532; 5123215 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Seibel, Nita Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Adolescents KW - Acute lymphatic leukemia KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41980532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Treatment+of+Acute+Lymphoblastic+Leukemia+in+Children+and+Adolescents%3A+Peaks+and+Pitfalls&rft.au=Seibel%2C+Nita&rft.aulast=Seibel&rft.aufirst=Nita&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mild Pro-Inflammatory State and Anemia in Older Persons T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41964691; 5123275 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Ferrucci, Luigi Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Anemia KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41964691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Mild+Pro-Inflammatory+State+and+Anemia+in+Older+Persons&rft.au=Ferrucci%2C+Luigi&rft.aulast=Ferrucci&rft.aufirst=Luigi&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Small-Molecule Therapeutics for Sickle Cell Disease: Nitric Oxide, Carbon Monoxide, Nitrite, and Apolipoprotein A T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41922479; 5123197 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Kato, Gregory Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Carbon monoxide KW - Nitrite KW - Nitric oxide KW - Apolipoprotein A KW - Sickle cell disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41922479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Novel+Small-Molecule+Therapeutics+for+Sickle+Cell+Disease%3A+Nitric+Oxide%2C+Carbon+Monoxide%2C+Nitrite%2C+and+Apolipoprotein+A&rft.au=Kato%2C+Gregory&rft.aulast=Kato&rft.aufirst=Gregory&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biology Lessons From Human Disease--the Pathophysiology of Bone Marrow Failure T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41902609; 5123114 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Young, Neal Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Bone marrow KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Biology+Lessons+From+Human+Disease--the+Pathophysiology+of+Bone+Marrow+Failure&rft.au=Young%2C+Neal&rft.aulast=Young&rft.aufirst=Neal&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insights on the "Oaks" of the Forest of Life T2 - 6th Annual Rocky Mountain Bioinformatics Conference (ROCKY 2008) AN - 41693291; 4999581 JF - 6th Annual Rocky Mountain Bioinformatics Conference (ROCKY 2008) AU - Puigbo, Pere Y1 - 2008/12/04/ PY - 2008 DA - 2008 Dec 04 KW - Forests KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41693291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28ROCKY+2008%29&rft.atitle=Insights+on+the+%22Oaks%22+of+the+Forest+of+Life&rft.au=Puigbo%2C+Pere&rft.aulast=Puigbo&rft.aufirst=Pere&rft.date=2008-12-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28ROCKY+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/cms_addon/conferences/rocky08/pdf/ProgramBookRocky 08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Obesity, Mammography Use and Accuracy, and Advanced Breast Cancer Risk AN - 20457905; 9145974 AB - Background Being overweight or obese is associated with increased breast cancer risk and disease severity among postmenopausal women, but whether extent of mammography use and accuracy modify this association and further contribute to increases in disease severity at diagnosis among overweight and obese women is unclear.Methods We prospectively collected data during 1996-2005 on 287115 postmenopausal women not using hormone therapy (HT) who underwent 614562 mammography examinations; 4446 women were diagnosed with breast cancer within 12 months of a mammography examination. We calculated rates per 1000 mammography examinations of large (>15 mm), advanced-stage (IIb, III, or IV), high-grade (3 or 4), estrogen receptor (ER)-positive and -negative, and screen-detected and non-screen-detected breast cancer across body mass index (BMI, kg/m2 ) groups defined as normal (18.5-24.9), overweight (25.0-29.9), obese class I (30.0-34.9), and obese class II/III ( greater than or equal to 35.0), adjusting for age, race/ethnicity, and mammography registry and use. All statistical tests were two-sided.Results Adjusted rates per 1000 mammography examinations of overall breast cancer increased across BMI groups (6.6 normal, 7.4 overweight, 7.9 obese I, 8.5 obese II/III; Ptrend < .001), as did rates of advanced disease, including large invasive (2.3 normal, 2.6 overweight, 2.9 obese I, 3.2 obese II/III; Ptrend < .001), advanced-stage (0.8 normal, 0.9 overweight, 1.3 obese I, 1.5 obese II/III; Ptrend < .001), and high nuclear grade (1.5 normal, 1.7 overweight, 1.7 obese I, 1.9 obese II/III; Ptrend = .10) tumors. Rates of ER-positive tumors increased across BMI groups (Ptrend < .001); rates of ER-negative tumors did not. Rates of screen-detected cancers were higher among overweight and obese women than normal and underweight women, but rates of non-screen-detected (false-negative) cancers were similar. Rates of advanced breast cancer increased across BMI groups regardless of extent of mammography use.Conclusions Patterns of mammography use and mammography accuracy are not the primary reasons for higher rates of advanced breast cancer among overweight and obese postmenopausal women not using HT; thus, biologic differences in breast tumor development and/or progression may be important. JF - Journal of the National Cancer Institute AU - Kerlikowske, Karla AU - Walker, Rod AU - Miglioretti, Diana L AU - Desai, Arati AU - Ballard-Barbash, Rachel AU - Buist, Diana SM AD - Affiliations of authors: Departments of Epidemiology and Biostatistics (KK) and General Internal Medicine Section, Department of Veterans Affairs, University of California, San Francisco, CA (KK); Group Health Center for Health Studies, Seattle, WA (RW, DLM, DSMB); Department of Biostatistics, University of Washington, Seattle, WA (DLM); Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (AD); Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD (RBB), karla.kerlikowske@ucsf.edu Y1 - 2008/12/03/ PY - 2008 DA - 2008 Dec 03 SP - 1724 EP - 1733 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 23 SN - 0027-8874, 0027-8874 KW - Physical Education Index; Risk Abstracts KW - Obesity KW - Age KW - Mammography KW - post-menopause KW - Body mass KW - Women KW - obesity KW - tumors KW - Breasts KW - Tumors KW - Hormones KW - Cancer KW - Evaluation KW - body mass KW - Breast cancer KW - Diseases KW - Ethnic groups KW - estrogens KW - PE 090:Sports Medicine & Exercise Sport Science KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20457905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Obesity%2C+Mammography+Use+and+Accuracy%2C+and+Advanced+Breast+Cancer+Risk&rft.au=Kerlikowske%2C+Karla%3BWalker%2C+Rod%3BMiglioretti%2C+Diana+L%3BDesai%2C+Arati%3BBallard-Barbash%2C+Rachel%3BBuist%2C+Diana+SM&rft.aulast=Kerlikowske&rft.aufirst=Karla&rft.date=2008-12-03&rft.volume=100&rft.issue=23&rft.spage=1724&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn388 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Mammography; Body mass; Women; Breasts; Diseases; Tumors; Cancer; Age; post-menopause; body mass; obesity; Breast cancer; tumors; Hormones; Ethnic groups; estrogens DO - http://dx.doi.org/10.1093/jnci/djn388 ER - TY - JOUR T1 - Fat, Protein, and Meat Consumption and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies AN - 20456720; 9145971 AB - Background Results of several case-control studies suggest that high consumption of meat (all meat, red meat, or processed meat) is associated with an increased risk of renal cell cancer, but only a few prospective studies have examined the associations of intakes of meat, fat, and protein with renal cell cancer.Methods We conducted a pooled analysis of 13 prospective studies that included 530469 women and 244483 men and had follow-up times of up to 7-20 years to examine associations between meat, fat, and protein intakes and the risk of renal cell cancer. All participants had completed a validated food frequency questionnaire at study entry. Using the primary data from each study, we calculated the study-specific relative risks (RRs) for renal cell cancer by using Cox proportional hazards models and then pooled these RRs by using a random-effects model. All statistical tests were two-sided.Results A total of 1478 incident cases of renal cell cancer were identified (709 in women and 769 in men). We observed statistically significant positive associations or trends in pooled age-adjusted models for intakes of total fat, saturated fat, monounsaturated fat, polyunsaturated fat, cholesterol, total protein, and animal protein. However, these associations were attenuated and no longer statistically significant after adjusting for body mass index, fruit and vegetable intake, and alcohol intake. For example, the pooled age-adjusted RR of renal cell cancer for the highest vs the lowest quintile of intake for total fat was 1.30 (95% confidence interval [CI] = 1.08 to 1.56; Ptrend = .001) and for total protein was 1.17 (95% CI = 0.99 to 1.38; Ptrend = .02). By comparison, the pooled multivariable RR for the highest vs the lowest quintile of total fat intake was 1.10 (95% CI = 0.92 to 1.32; Ptrend = .31) and of total protein intake was 1.06 (95% CI = 0.89 to 1.26; Ptrend = .37). Intakes of red meat, processed meat, poultry, or seafood were not associated with the risk of renal cell cancer.Conclusions Intakes of fat and protein or their subtypes, red meat, processed meat, poultry, and seafood are not associated with risk of renal cell cancer. JF - Journal of the National Cancer Institute AU - Lee, Jung Eun AU - Spiegelman, Donna AU - Hunter, David J AU - Albanes, Demetrius AU - Bernstein, Leslie AU - van den Brandt, Piet A AU - Buring, Julie E AU - Cho, Eunyoung AU - English, Dallas R AU - Freudenheim, Jo L AU - Giles, Graham G AU - Graham, Saxon AU - Horn-Ross, Pamela L AU - Haakansson, Niclas AU - Leitzmann, Michael F AU - Maennistoe, Satu AU - McCullough, Marjorie L AU - Miller, Anthony B AU - Parker, Alexander S AU - Rohan, Thomas E AU - Schatzkin, Arthur AU - Schouten, Leo J AU - Sweeney, Carol AU - Willett, Walter C AU - Wolk, Alicja AU - Zhang, Shumin M AU - Smith-Warner, Stephanie A AD - Affiliations of authors: Channing Laboratory (JEL, DJH, EC, WCW) and Division of Preventive Medicine (JEB, SMZ), Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA; Department of Epidemiology (DS, DJH, JEB, WCW, SASW), Department of Nutrition (DJH, WCW, SASW), and Department of Biostatistics (DS), Harvard School of Public Health, Boston, MA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Health Services, Bethesda, MD (DA, MFL, AS); City of Hope Comprehensive Cancer Center and Beckman Research Institute, City of Hope National Medical Center, Duarte, CA (LB); Department of Epidemiology, GROW-School for Oncology and Developmental Biology, University Maastricht, Maastricht, The Netherlands (PAvdB, LJS); Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia (DRE, GGG); Department of Social and Preventive Medicine, University at Buffalo, State U, jung.lee@channing.harvard.edu Y1 - 2008/12/03/ PY - 2008 DA - 2008 Dec 03 SP - 1695 EP - 1706 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 23 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Alcohol KW - poultry KW - body mass KW - fruits KW - Proteins KW - Seafood KW - cholesterol KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20456720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Fat%2C+Protein%2C+and+Meat+Consumption+and+Renal+Cell+Cancer+Risk%3A+A+Pooled+Analysis+of+13+Prospective+Studies&rft.au=Lee%2C+Jung+Eun%3BSpiegelman%2C+Donna%3BHunter%2C+David+J%3BAlbanes%2C+Demetrius%3BBernstein%2C+Leslie%3Bvan+den+Brandt%2C+Piet+A%3BBuring%2C+Julie+E%3BCho%2C+Eunyoung%3BEnglish%2C+Dallas+R%3BFreudenheim%2C+Jo+L%3BGiles%2C+Graham+G%3BGraham%2C+Saxon%3BHorn-Ross%2C+Pamela+L%3BHaakansson%2C+Niclas%3BLeitzmann%2C+Michael+F%3BMaennistoe%2C+Satu%3BMcCullough%2C+Marjorie+L%3BMiller%2C+Anthony+B%3BParker%2C+Alexander+S%3BRohan%2C+Thomas+E%3BSchatzkin%2C+Arthur%3BSchouten%2C+Leo+J%3BSweeney%2C+Carol%3BWillett%2C+Walter+C%3BWolk%2C+Alicja%3BZhang%2C+Shumin+M%3BSmith-Warner%2C+Stephanie+A&rft.aulast=Lee&rft.aufirst=Jung&rft.date=2008-12-03&rft.volume=100&rft.issue=23&rft.spage=1695&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn386 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Alcohol; poultry; body mass; fruits; Proteins; Seafood; cholesterol; Cancer DO - http://dx.doi.org/10.1093/jnci/djn386 ER - TY - JOUR T1 - Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users. AN - 69827185; 19034286 AB - Domestic fuel combustion from cooking and heating, to which about 3 billion people worldwide are exposed, is associated with increased lung cancer risk. Lung cancer incidence in Xuanwei is the highest in China, and the attributable risk of lung cancer from unvented smoky coal burning is greater than 90%. To evaluate any lung cancer mortality reduction after changing from unvented stoves to portable stoves, we used lifetime smoky coal users in a retrospective cohort of all farmers born during 1917-1951 and residing in Xuanwei in 1976. Of the 42,422 enrolled farmers, 4054 lifetime smoky coal users changed to portable stoves, 4364 did not change, and 1074 died of lung cancer. Lung cancer morality associated with stove change was assessed by product-limit survival curves and multivariate Cox regression models. Both men (P<0.0001) and women (P<0.0001) who changed to portable stoves had a significantly increased probability of survival compared with those who did not change. Portable stoves were associated with decreased risk of lung cancer mortality in male participants (hazard ratio (HR)=0.62, 95% confidence interval (CI)=0.46-0.82) and female participants (HR=0.41, 95% CI=0.29-0.57). Portable stove use is associated with reduced lung cancer mortality risk, highlighting a cost-effective intervention that could substantially benefit health in developing countries. JF - British journal of cancer AU - Hosgood, H D AU - Chapman, R AU - Shen, M AU - Blair, A AU - Chen, E AU - Zheng, T AU - Lee, K-M AU - He, X AU - Lan, Q AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7240, USA. hosgoodd@mail.nih.gov Y1 - 2008/12/02/ PY - 2008 DA - 2008 Dec 02 SP - 1934 EP - 1939 VL - 99 IS - 11 KW - Coal KW - 0 KW - Smoke KW - Index Medicus KW - Ventilation KW - Humans KW - China -- epidemiology KW - Surveys and Questionnaires KW - Retrospective Studies KW - Male KW - Female KW - Proportional Hazards Models KW - Smoke -- adverse effects KW - Air Pollution, Indoor -- adverse effects KW - Lung Neoplasms -- etiology KW - Coal -- adverse effects KW - Cooking -- methods KW - Lung Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69827185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Portable+stove+use+is+associated+with+lower+lung+cancer+mortality+risk+in+lifetime+smoky+coal+users.&rft.au=Hosgood%2C+H+D%3BChapman%2C+R%3BShen%2C+M%3BBlair%2C+A%3BChen%2C+E%3BZheng%2C+T%3BLee%2C+K-M%3BHe%2C+X%3BLan%2C+Q&rft.aulast=Hosgood&rft.aufirst=H&rft.date=2008-12-02&rft.volume=99&rft.issue=11&rft.spage=1934&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fsj.bjc.6604744 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-30 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Indoor Air. 2000 Sep;10(3):200-5 [10979201] Am J Epidemiol. 2007 Jun 1;165(11):1280-6 [17369610] Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Jun;23(3):186-9 [12411086] Toxicology. 2004 May 20;198(1-3):301-5 [15138056] Health Educ Res. 2004 Oct;19(5):543-50 [15199008] Science. 1987 Jan 9;235(4785):217-20 [3798109] Arch Environ Health. 1988 Mar-Apr;43(2):180-5 [3377554] J Natl Cancer Inst. 1989 Dec 6;81(23):1800-6 [2555531] IARC Sci Publ. 1991;(105):460-5 [1855896] Carcinogenesis. 1995 Dec;16(12):3031-6 [8603481] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Br J Cancer. 2005 Oct 3;93(7):825-33 [16160696] BMJ. 2005 Nov 5;331(7524):1050 [16234255] Soc Sci Med. 2006 Jun;62(12):3161-76 [16426715] Int J Hyg Environ Health. 2006 Sep;209(5):445-50 [16765087] J Epidemiol Community Health. 2007 Jan;61(1):74-9 [17183019] Lancet Oncol. 2006 Dec;7(12):977-8 [17348122] J Natl Cancer Inst. 2002 Jun 5;94(11):826-35 [12048270] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.bjc.6604744 ER - TY - JOUR T1 - Breast cancer incidence following low-dose rate environmental exposure: Techa River Cohort, 1956-2004. AN - 69824240; 19002173 AB - In the 1950s, the Mayak nuclear weapons facility in Russia discharged liquid radioactive wastes into the Techa River causing exposure of riverside residents to protracted low-to-moderate doses of radiation. Almost 10,000 women received estimated doses to the stomach of up to 0.47 Gray (Gy) (mean dose=0.04 Gy) from external gamma-exposure and (137)Cs incorporation. We have been following this population for cancer incidence and mortality and as in the general Russian population, we found a significant temporal trend of breast cancer incidence. A significant linear radiation dose-response relationship was observed (P=0.01) with an estimated excess relative risk per Gray (ERR/Gy) of 5.00 (95% confidence interval (CI), 0.80, 12.76). We estimated that approximately 12% of the 109 observed cases could be attributed to radiation. JF - British journal of cancer AU - Ostroumova, E AU - Preston, D L AU - Ron, E AU - Krestinina, L AU - Davis, F G AU - Kossenko, M AU - Akleyev, A AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MS 7238, 6120 Executive Boulevard, Bethesda, MD 20892-7238, USA. zhenia@urcrm.chel.su Y1 - 2008/12/02/ PY - 2008 DA - 2008 Dec 02 SP - 1940 EP - 1945 VL - 99 IS - 11 KW - Index Medicus KW - Humans KW - Incidence KW - Russia KW - Dose-Response Relationship, Radiation KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Radioactive Hazard Release KW - Neoplasms, Radiation-Induced -- epidemiology KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69824240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Breast+cancer+incidence+following+low-dose+rate+environmental+exposure%3A+Techa+River+Cohort%2C+1956-2004.&rft.au=Ostroumova%2C+E%3BPreston%2C+D+L%3BRon%2C+E%3BKrestinina%2C+L%3BDavis%2C+F+G%3BKossenko%2C+M%3BAkleyev%2C+A&rft.aulast=Ostroumova&rft.aufirst=E&rft.date=2008-12-02&rft.volume=99&rft.issue=11&rft.spage=1940&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fsj.bjc.6604775 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-30 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1984 Jul 15;34(1):71-5 [6746122] Vopr Onkol. 1982;28(10):26-71 [7147820] Int J Epidemiol. 1989 Sep;18(3):498-510 [2807650] Radiat Res. 1991 Feb;125(2):214-22 [1996380] Cancer Causes Control. 1990 Jul;1(1):39-49 [2102275] Vopr Onkol. 1991;37(4):401-36 [1887640] J Natl Cancer Inst. 1993 Oct 20;85(20):1679-85 [8411245] Vopr Onkol. 1992;38(12):1413-83 [1343179] Sci Total Environ. 1994 Mar 1;142(1-2):1-8 [8178126] Sci Total Environ. 1994 Mar 1;142(1-2):49-61 [8178136] Radiat Res. 1999 May;151(5):626-32 [10319736] Radiat Res. 2005 Oct;164(4 Pt 1):409-19 [16187743] Radiat Res. 2005 Nov;164(5):591-601 [16238436] Radiat Res. 2005 Nov;164(5):602-11 [16238437] Int J Cancer. 2006 Aug 1;119(3):651-8 [16506213] J Travel Med. 2006 May-Jun;13(3):127-32 [16706942] Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Radiat Res. 2006 Jul;166(1 Pt 2):255-70 [16808612] Radiat Res. 2007 Jul;168(1):1-64 [17722996] Int J Epidemiol. 2007 Oct;36(5):1038-46 [17768163] Health Phys. 2000 May;78(5):542-54 [10772028] Health Phys. 2000 Jul;79(1):24-35 [10855775] Spine (Phila Pa 1976). 2000 Aug 15;25(16):2052-63 [10954636] Cancer Causes Control. 2001 Feb;12(2):95-101 [11246849] Health Phys. 2002 Apr;82(4):455-66 [11906134] Radiat Res. 2002 Aug;158(2):220-35 [12105993] Radiat Environ Biophys. 2003 Oct;42(3):169-74 [14579133] Radiat Res. 2003 Dec;160(6):707-17 [14640793] Vopr Onkol. 1975;21(1):3-16 [163550] N Engl J Med. 1989 Nov 9;321(19):1281-4 [2797100] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.bjc.6604775 ER - TY - JOUR T1 - Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry AN - 883023686; 15305944 AB - The HIV-1 co-receptor CCR5 possesses sulfo-tyrosine (TYS) residues at its N-terminus (Nt) that are required for binding HIV-1 gp120 and mediating viral entry. By using a 14-residue fragment of CCR5 Nt containing two TYS residues, we recently showed that CCR5 Nt binds gp120 through a conserved region specific for TYS moieties and suggested that this site may represent a target for inhibitors and probes of HIV-1 entry. As peptides containing sulfo-tyrosines are difficult to synthesize and handle due to limited stability of the sulfo-ester moiety, we have now incorporated TYS isosteres into CCR5 Nt analogs and assessed their binding to a complex of gp120-CD4 using saturation transfer difference (STD) NMR and surface plasmon resonance (SPR). STD enhancements for CCR5 Nt peptides containing tyrosine sulfonate (TYSN) in complex with gp120-CD4 were very similar to those observed for sulfated CCR5 Nt peptides indicating comparable modes of binding. STD enhancements for phosphotyrosine-containing CCR5 Nt analogs were greatly diminished consistent with earlier findings showing sulfo-tyrosine to be essential for CCR5 Nt binding to gp120. Tyrosine sulfonate-containing CCR5 peptides exhibited reduced water solubility, limiting their use in assay and probe development. To improve solubility, we designed, synthesized, and incorporated in CCR5 Nt peptide analogs an orthogonally functionalized azido tris(ethylenoxy) l-alanine (l-ate-Ala) residue. Through NMR and SPR experiments, we show a 19-residue TYSN-containing peptide to be a functional, hydrolytically stable CCR5 Nt isostere that was in turn used to develop both SPR-based and ELISA assays to screen for inhibitors of CCR5 binding to gp120-CD4. JF - Bioorganic and Medicinal Chemistry AU - Lam, Son N AU - Acharya, Priyamvada AU - Wyatt, Richard AU - Kwong, Peter D AU - Bewley, Carole A Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 10113 EP - 10120 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 16 IS - 23 SN - 0968-0896, 0968-0896 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - CCR5 protein KW - Development KW - Enzyme-linked immunosorbent assay KW - Glycoprotein gp120 KW - L-Alanine KW - N-Terminus KW - N.M.R. KW - Probes KW - Solubility KW - Tyrosine KW - surface plasmon resonance KW - Human immunodeficiency virus 1 KW - V 22360:AIDS and HIV KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883023686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Tyrosine-sulfate+isosteres+of+CCR5+N-terminus+as+tools+for+studying+HIV-1+entry&rft.au=Lam%2C+Son+N%3BAcharya%2C+Priyamvada%3BWyatt%2C+Richard%3BKwong%2C+Peter+D%3BBewley%2C+Carole+A&rft.aulast=Lam&rft.aufirst=Son&rft.date=2008-12-01&rft.volume=16&rft.issue=23&rft.spage=10113&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-02-22 N1 - SubjectsTermNotLitGenreText - Glycoprotein gp120; Enzyme-linked immunosorbent assay; surface plasmon resonance; Solubility; L-Alanine; Probes; Tyrosine; N.M.R.; CCR5 protein; Development; N-Terminus; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bmc.2008.10.005 ER - TY - JOUR T1 - Literacy-Based Normative Data For Low Socioeconomic Status African Americans AN - 85692413; 200906967 AB - Clinical neuropsychology relies on the use of appropriate test norms. Normative studies frequently stratify based on age, education, sex, and race. None to date has reported norms based on literacy, despite the substantial evidence that literacy impacts cognitive functioning. Some researchers have suggested that literacy is a more accurate reflection of academic achievement and quality of education than years of education, particularly for African Americans. The current study provides literacy-based normative data for multiple neuropsychological measures based on a sample of predominantly low socioeconomic status African Americans. These normative data should improve the diagnostic accuracy of performances by African-American clients with similar demographic backgrounds. Adapted from the source document JF - The Clinical Neuropsychologist AU - Dotson, Vonetta M AU - Kitner-Triolo, Melissa AU - Evans, Michele K AU - Zonderman, Alan B AD - National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Dr., Baltimore, MD 21224, USA dotsonv@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 989 EP - 1017 VL - 22 IS - 6 SN - 1385-4046, 1385-4046 KW - Literacy (48550) KW - Diagnostic Tests (18550) KW - Black Americans (09100) KW - Socioeconomic Status (80150) KW - Academic Achievement (00070) KW - Test Validity and Reliability (88800) KW - Neuropsychological Assessment (57285) KW - article KW - 4115: applied linguistics; adult language development/literacy studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85692413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=Literacy-Based+Normative+Data+For+Low+Socioeconomic+Status+African+Americans&rft.au=Dotson%2C+Vonetta+M%3BKitner-Triolo%2C+Melissa%3BEvans%2C+Michele+K%3BZonderman%2C+Alan+B&rft.aulast=Dotson&rft.aufirst=Vonetta&rft.date=2008-12-01&rft.volume=22&rft.issue=6&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Literacy (48550); Socioeconomic Status (80150); Test Validity and Reliability (88800); Black Americans (09100); Academic Achievement (00070); Neuropsychological Assessment (57285); Diagnostic Tests (18550) ER - TY - JOUR T1 - Introduction to the Special Section: Transformative Research on Emotion Regulation and Dysregulation AN - 839605670; 201100972 AB - Scholars are giving increased attention to the need to incorporate research on more basic developmental processes into new paradigms for understanding and treating mental illness in children and adolescents. The study of emotion regulation, rooted in neurodevelopment, has proven a fruitful model for understanding and characterizing problems of behavior and risk in children and adolescents. This article summarizes NIMH initiatives designed to encourage transformational research on the neurodevelopment origins of mental illness. It highlights the NIMH Strategic Plan and the Report on Transformative Neurodevelopment Research as part of an introduction to a collection of articles that grew out of a previously organized NIMH workshop on developmental and translational models of emotion regulation and dysregulation. Adapted from the source document. JF - Child Development Perspectives AU - Delcarmen-Wiggins, Rebecca Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 121 EP - 123 PB - Wiley Publishing, Malden, MA 02148 VL - 2 IS - 3 SN - 1750-8592, 1750-8592 KW - emotion regulation KW - neurodevelopment KW - translational models KW - transformational research KW - Workshops KW - Mental illness KW - Developmental processes KW - Emotional regulation KW - Children KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839605670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development+Perspectives&rft.atitle=Introduction+to+the+Special+Section%3A+Transformative+Research+on+Emotion+Regulation+and+Dysregulation&rft.au=Delcarmen-Wiggins%2C+Rebecca&rft.aulast=Delcarmen-Wiggins&rft.aufirst=Rebecca&rft.date=2008-12-01&rft.volume=2&rft.issue=3&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Child+Development+Perspectives&rft.issn=17508592&rft_id=info:doi/10.1111%2Fj.1750-8606.2008.00053.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Emotional regulation; Mental illness; Adolescents; Children; Workshops; Developmental processes DO - http://dx.doi.org/10.1111/j.1750-8606.2008.00053.x ER - TY - JOUR T1 - Fetal alcohol spectrum disorder. AN - 69943829; 19129565 AB - Maternal alcohol use during pregnancy leads to fetal alcohol spectrum disorder (FASD) in their children. FASD is characterized by typical facial features, growth retardation, intellectual dysfunction and behavioral problems. Alcohol is neurotoxic to the brain during the developmental stage. Behavioral problems in children with FASD start at an early age and progress to adulthood. It is an important preventable cause of intellectual dysfunction and behavioral problems. This article reviews current prevalence, clinical features, pathogenesis and differential diagnosis of FASD. It also highlights the need for physicians to be aware of this condition. Articles were searched on the internet using fetal alcohol syndrome, fetal alcohol spectrum disorders, women and alcohol. Following links were used to locate journals; EBSCO, OVID, Science Direct, PubMed and NIAAA. Alcohol consumption during pregnancy can lead to a spectrum of deficits. Though physical features are essential to make the diagnosis of FAS, it is important to note that neurocognitive and behavioural deficits can be present in the absence of physical features (alcohol related neurodevelopmental disorder or ARND). Because there is no known safe amount of alcohol consumption during pregnancy, abstinence from alcohol for women who are pregnant or planning a pregnancy must be strongly advised. JF - Indian pediatrics AU - Nayak, Raghavendra Bheemappa AU - Murthy, Pratima AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 29, India. rbn.psych@gmail.com Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 977 EP - 983 VL - 45 IS - 12 SN - 0019-6061, 0019-6061 KW - Index Medicus KW - India -- epidemiology KW - Risk Factors KW - Humans KW - Female KW - Prevalence KW - Pregnancy KW - Maternal Behavior KW - Risk-Taking KW - Alcohol Drinking -- adverse effects KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Fetal Alcohol Spectrum Disorders -- etiology KW - Fetal Alcohol Spectrum Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69943829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+pediatrics&rft.atitle=Fetal+alcohol+spectrum+disorder.&rft.au=Nayak%2C+Raghavendra+Bheemappa%3BMurthy%2C+Pratima&rft.aulast=Nayak&rft.aufirst=Raghavendra&rft.date=2008-12-01&rft.volume=45&rft.issue=12&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Indian+pediatrics&rft.issn=00196061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2009-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques. AN - 69940862; 18978308 AB - Chemical exposures are important risks for development of hepatocellular carcinoma (HCC). One such chemical, diethylnitrosamine (DENA), is present in food products as well as in industrial and research settings. Further examination of tumors induced by DENA may yield clues to human risk. HCC from seven rhesus macaques exposed to DENA was selected from a tissue archive to examine for evidence of Wnt/beta-catenin signaling events, which are frequently associated with HCC. DENA exposure durations ranged from 8 to 207 months, and total accumulated dose ranged from 0.7 to 4.08 mg. Unexposed colony breeder macaques served as controls. Previously unrecognized HCC metastases were discovered in lungs of three macaques. Overexpression of beta-catenin and glutamine synthetase was detected by immunohistochemistry in six confirmed primary HCC and all metastatic HCC, which implicated Wnt/beta-catenin activation. Concomitant beta-catenin gene mutation was detected in one primary HCC; similar findings have been reported in human and rodent HCC. Neither beta-catenin mutation nor beta-catenin overexpression appeared to influence metastatic potential. Accumulation of intracellular proteins involved in Wnt/beta-catenin signaling during HCC oncogenesis in rhesus macaques exposed to DENA appears to include other mechanisms, in addition to mutation of beta-catenin gene. JF - Toxicologic pathology AU - Wei, Bih-Rong AU - Edwards, Jennifer B AU - Hoover, Shelley B AU - Tillman, Heather S AU - Reed, L Tiffany AU - Sills, Robert C AU - Simpson, R Mark AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 972 EP - 980 VL - 36 IS - 7 KW - Carcinogens KW - 0 KW - beta Catenin KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Glutamate-Ammonia Ligase KW - EC 6.3.1.2 KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Glutamate-Ammonia Ligase -- metabolism KW - Carcinogens -- toxicity KW - Carcinogenicity Tests KW - Macaca mulatta KW - Sequence Analysis, DNA KW - Tissue Banks KW - Immunohistochemistry KW - Diethylnitrosamine -- toxicity KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - beta Catenin -- metabolism KW - Liver Neoplasms -- chemically induced KW - beta Catenin -- genetics KW - Carcinoma, Hepatocellular -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69940862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Altered+%7Bbeta%7D-catenin+accumulation+in+hepatocellular+carcinomas+of+diethylnitrosamine-exposed+rhesus+macaques.&rft.au=Wei%2C+Bih-Rong%3BEdwards%2C+Jennifer+B%3BHoover%2C+Shelley+B%3BTillman%2C+Heather+S%3BReed%2C+L+Tiffany%3BSills%2C+Robert+C%3BSimpson%2C+R+Mark&rft.aulast=Wei&rft.aufirst=Bih-Rong&rft.date=2008-12-01&rft.volume=36&rft.issue=7&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308327120 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-06 N1 - Date created - 2009-01-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 1999 Nov 11;18(47):6583-8 [10597262] J Hepatol. 2008 May;48(5):884-6 [18314218] Eur J Cancer. 2001 Oct;37 Suppl 8:S4-66 [11602373] Oncogene. 2001 Nov 22;20(53):7812-6 [11753661] Cancer. 2002 Feb 25;96(1):49-52 [11836703] Biochim Biophys Acta. 2003 Jun 5;1653(1):1-24 [12781368] Gastroenterology. 2004 May;126(5):1374-86 [15131798] Carcinogenesis. 2004 Jun;25(6):901-8 [14742323] IARC Monogr Eval Carcinog Risk Chem Man. 1978 May;17:1-349 [150392] Cancer Res. 1983 Sep;43(9):4253-9 [6871863] Cancer Res. 1992 Sep 15;52(18):5042-5 [1516060] Regul Toxicol Pharmacol. 1994 Apr;19(2):130-51 [8041912] Cancer Res. 1998 Jun 15;58(12):2524-7 [9635572] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8847-51 [9671767] Cancer Res. 1999 Apr 15;59(8):1830-3 [10213486] Am J Pathol. 1999 Sep;155(3):703-10 [10487827] Semin Liver Dis. 1999;19(3):271-85 [10518307] Toxicol Pathol. 2005;33(1):175-80 [15805069] J Hepatol. 2005 Jun;42(6):842-9 [15885355] Semin Liver Dis. 2005;25(2):212-25 [15918149] Exp Mol Med. 2006 Feb 28;38(1):1-10 [16520547] Prostate. 2006 May 1;66(6):567-77 [16372335] Oncogene. 2006 Jun 26;25(27):3778-86 [16799619] Oncogene. 2006 Jun 26;25(27):3787-800 [16799620] Oncogene. 2007 Feb 1;26(5):774-80 [16964294] Hepatology. 2007 May;45(5):1298-305 [17464972] J Pathol. 2007 Jul;212(3):345-52 [17487939] Clin Cancer Res. 2007 Jul 15;13(14):4042-5 [17634527] Physiology (Bethesda). 2007 Oct;22:303-9 [17928543] J Gastroenterol Hepatol. 2008 Jan;23(1):110-8 [18171349] Cancer Res. 2001 Mar 1;61(5):2085-91 [11280770] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308327120 ER - TY - JOUR T1 - Vasopressin does not mediate hypersensitivity of the hypothalamic pituitary adrenal axis during chronic stress. AN - 69934617; 19120128 AB - The hypothesis that vasopressin (VP) becomes the main mediator of pituitary corticotroph responsiveness during chronic hypothalamic pituitary adrenal (HPA) axis activation was tested by examining the effect of pharmacologic VP receptor blockade on the adrenocorticotropic hormone (ACTH) and corticosterone responses of 14-day repeatedly restrained rats. In spite of the increased vasopressinergic activity, repeatedly restrained rats showed lower ACTH and corticosterone responses to 10 min white noise compared with handled controls. These responses were unchanged by injection of the nonpeptide-selective V1b receptor antagonist SSR149415 i.v., 1 h before noise application. In contrast to noise stress, plasma ACTH responses to i.p. hypertonic saline injection were enhanced in the repeatedly restrained rats compared with handled controls, but responses were also unaffected by SSR149415 administered orally, daily 1 h before restraint. Since SSR149415 effectiveness was low, we used minipump infusion of the peptide V1 receptor antagonist, dGly[Phaa1,D-tyr(et), Lys, Arg]VP (V1-Ant) for 14 days, which effectively blocked ACTH responses to exogenous VP. Chronic V1-Ant infusion reduced plasma ACTH responses to i.p. hypertonic saline in handled controls but not in repeatedly restrained rats. These data suggest that the increased vasopressinergic activity characteristic of chronic stress plays roles other than mediating the hypersensitivity of the HPA axis to a novel stress. JF - Annals of the New York Academy of Sciences AU - Chen, Jun AU - Young, Sharla AU - Subburaju, Sivan AU - Sheppard, Jack AU - Kiss, Alexander AU - Atkinson, Helen AU - Wood, Susan AU - Lightman, Stafford AU - Serradeil-Le Gal, Claudine AU - Aguilera, Greti AD - Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 349 EP - 359 VL - 1148 KW - 1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide KW - 0 KW - Antidiuretic Hormone Receptor Antagonists KW - Indoles KW - Pyrrolidines KW - Receptors, Vasopressin KW - Vasopressins KW - 11000-17-2 KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Receptors, Vasopressin -- metabolism KW - Drinking KW - Animals KW - Restraint, Physical KW - Humans KW - Pyrrolidines -- metabolism KW - Rats KW - Body Weight KW - Eating KW - Rats, Sprague-Dawley KW - Corticosterone -- blood KW - Noise KW - Indoles -- metabolism KW - Male KW - Adrenocorticotropic Hormone -- blood KW - Hypothalamo-Hypophyseal System -- physiology KW - Vasopressins -- metabolism KW - Stress, Psychological KW - Pituitary-Adrenal System -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69934617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Vasopressin+does+not+mediate+hypersensitivity+of+the+hypothalamic+pituitary+adrenal+axis+during+chronic+stress.&rft.au=Chen%2C+Jun%3BYoung%2C+Sharla%3BSubburaju%2C+Sivan%3BSheppard%2C+Jack%3BKiss%2C+Alexander%3BAtkinson%2C+Helen%3BWood%2C+Susan%3BLightman%2C+Stafford%3BSerradeil-Le+Gal%2C+Claudine%3BAguilera%2C+Greti&rft.aulast=Chen&rft.aufirst=Jun&rft.date=2008-12-01&rft.volume=1148&rft.issue=&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1410.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1990 Nov 5;532(1-2):34-40 [2178035] Endocrinology. 1989 Jul;125(1):28-34 [2544403] Neuroendocrinology. 1991 Dec;54(6):635-8 [1664502] J Endocrinol. 1992 Sep;134(3):327-39 [1402543] Endocrinology. 1993 Jan;132(1):241-8 [8380375] Front Neuroendocrinol. 1993 Apr;14(2):76-122 [8387436] Front Neuroendocrinol. 1994 Dec;15(4):321-50 [7895891] Br J Pharmacol. 1995 Nov;116(5):2417-24 [8581278] Endocrinology. 1997 Oct;138(10):4351-7 [9322950] Endocrinology. 1998 Feb;139(2):443-50 [9449609] Brain Res Mol Brain Res. 1999 May 7;68(1-2):129-40 [10320790] Endocrinology. 1999 Aug;140(8):3623-32 [10433220] Proc Soc Exp Biol Med. 1954 Nov;87(2):318-24 [13237230] CNS Drug Rev. 2005 Spring;11(1):53-68 [15867952] Endocrinology. 2007 Feb;148(2):849-56 [17122081] J Neuroendocrinol. 2007 Mar;19(3):189-97 [17280592] J Neuroendocrinol. 2007 Jul;19(7):543-51 [17561882] Endocrinology. 2007 Jul;148(7):3102-10 [17412807] Peptides. 1990 Jan-Feb;11(1):59-63 [2160653] Neuroscience. 1999;94(3):797-802 [10579570] Regul Pept. 2000 Dec 22;96(1-2):23-9 [11102648] J Neuroendocrinol. 2001 Aug;13(8):711-23 [11489088] J Pharmacol Exp Ther. 2002 Mar;300(3):1122-30 [11861823] J Clin Invest. 2004 Jan;113(2):302-9 [14722621] Physiol Behav. 2004 Jun;81(4):557-68 [15178148] Brain Res Bull. 2004 Jul 15;63(6):521-30 [15249118] Nature. 1982 Sep 23;299(5881):355-7 [6287293] Proc Natl Acad Sci U S A. 1984 Mar;81(6):1883-7 [6369332] J Biol Chem. 1987 Jan 25;262(3):1129-36 [2433273] Endocrinology. 1988 Jul;123(1):396-405 [2838259] Endocrinology. 1989 Jun;124(6):3102-8 [2542009] Neuroendocrinology. 1991 Feb;53(2):150-9 [1849619] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1410.037 ER - TY - JOUR T1 - Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders. AN - 69934385; 18828796 AB - Existing studies of the association between age at first drink (AFD) and the risk of alcohol use disorders (AUD) suffer from inconsistent levels of control and designs that may inflate associations by failure to control for duration of exposure to risk. This study examined associations between AFD (ages <15 and 15-17 vs. 18+ years) and first incidence of DSM-IV alcohol dependence, abuse, and specific AUD criteria over a 3-year follow-up in a longitudinal study of U.S. drinkers 18 years of age and older at baseline (n = 22,316), controlling for duration of exposure, family history, and a wide range of baseline and childhood risk factors. After adjusting for all risk factors, the incidence of dependence was increased for AFD <15 years (OR = 1.38) and for women only with AFD at ages 15 to 17 (OR = 1.54). The incidence of abuse was increased at AFD <15 and 15 to 17 years (OR = 1.52 and 1.30, respectively). Most dependence criteria showed significant associations with AFD, but hazardous drinking and continued drinking despite interpersonal problems were the only abuse criteria to do so. All associations were nonsignificant after controlling for volume of consumption, except that AFD at all ages <18 combined was associated with a reduced likelihood of impaired control, and AFD at ages 15 to 17 was associated with lower odds of drinking more/longer than intended among heavy-volume drinkers. In a population of low-risk drinkers that excluded those with positive family histories, personality disorders, and childhood risk factors, there were strong associations between early AFD (<18) and the incidence of dependence (OR = 3.79) and continued drinking despite physical/psychological problems (OR = 2.71), but no association with incidence of abuse. There is a robust association between AFD and the risk of AUD that appears to reflect willful rather than uncontrolled heavy drinking, consistent with misuse governed by poor decision-making and/or reward-processing skills associated with impaired executive cognitive function (ECF). Additional research is needed to determine causality in the role of impaired ECF, including longitudinal studies with samples of low-risk adolescents. JF - Alcoholism, clinical and experimental research AU - Dawson, Deborah A AU - Goldstein, Risë B AU - Chou, S Patricia AU - Ruan, W June AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9304, USA. ddawson@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2149 EP - 2160 VL - 32 IS - 12 KW - Index Medicus KW - Young Adult KW - Age Factors KW - Risk Factors KW - Humans KW - Incidence KW - Follow-Up Studies KW - Longitudinal Studies KW - Adolescent KW - Male KW - Female KW - Alcohol-Related Disorders -- diagnosis KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- epidemiology KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcohol-Related Disorders -- psychology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69934385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Age+at+first+drink+and+the+first+incidence+of+adult-onset+DSM-IV+alcohol+use+disorders.&rft.au=Dawson%2C+Deborah+A%3BGoldstein%2C+Ris%C3%AB+B%3BChou%2C+S+Patricia%3BRuan%2C+W+June%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2008-12-01&rft.volume=32&rft.issue=12&rft.spage=2149&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/10.1111%2Fj.1530-0277.2008.00806.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-09 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Psychiatry. 1990 Nov;147(11):1537-41 [2221170] Mol Psychiatry. 2009 Nov;14(11):1051-66 [18427559] Addiction. 1999 Jun;94(6):843-55 [10665074] Am J Psychiatry. 2000 May;157(5):745-50 [10784467] Biol Psychiatry. 2000 Aug 15;48(4):265-75 [10960157] Am J Psychiatry. 2001 Jul;158(7):1084-90 [11431230] Alcohol Clin Exp Res. 2001 Aug;25(8):1156-65 [11505047] Alcohol Clin Exp Res. 2001 Aug;25(8):1166-73 [11515563] J Subst Abuse. 2001;13(4):493-504 [11775078] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Subst Use Misuse. 2003 Dec;38(14):1983-2016 [14677779] Alcohol Clin Exp Res. 2004 Sep;28(9):1379-87 [15365309] J Pers Soc Psychol. 1986 Dec;51(6):1173-82 [3806354] Am J Psychiatry. 1991 Nov;148(11):1501-4 [1928463] J Pers Soc Psychol. 1991 Oct;61(4):614-28 [1960653] Br J Addict. 1992 Aug;87(8):1199-204 [1511233] Addiction. 1993 Aug;88(8):1079-90 [8401162] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Alcohol Clin Exp Res. 1995 Aug;19(4):1018-23 [7485811] J Stud Alcohol. 1997 Jul;58(4):397-404 [9203121] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] J Subst Abuse. 1997;9:103-10 [9494942] J Stud Alcohol. 1998 Jan;59(1):32-42 [9498313] Recent Dev Alcohol. 1998;14:227-51 [9751948] Addiction. 1998 Oct;93(10):1511-20 [9926555] Alcohol Clin Exp Res. 1999 Jan;23(1):101-7 [10029209] Am J Addict. 1999 Summer;8(3):190-200 [10506900] Alcohol Health Res World. 1998;22(2):144-7 [15706789] Addiction. 2005 May;100(5):652-61 [15847623] Alcohol Clin Exp Res. 2005 Oct;29(10):1869-76 [16269917] Behav Genet. 2006 Mar;36(2):195-200 [16402286] Arch Pediatr Adolesc Med. 2006 Jul;160(7):739-46 [16818840] Addiction. 2007 Feb;102(2):216-25 [17222275] J Stud Alcohol Drugs. 2007 Mar;68(2):256-65 [17286344] Drug Alcohol Depend. 2007 Jul 10;89(2-3):139-44 [17227698] Alcohol Clin Exp Res. 2007 Jun;31(6):928-38 [17403069] Drug Alcohol Depend. 2007 Nov 2;91(1):26-39 [17553635] Arch Pediatr Adolesc Med. 2007 Oct;161(10):959-66 [17909139] Drug Alcohol Depend. 2008 Jan 1;92(1-3):27-36 [17706375] Neuropsychologia. 2008 Jan 31;46(2):714-26 [17996909] Alcohol Clin Exp Res. 2008 Mar;32(3):373-4 [18302721] Alcohol Clin Exp Res. 2008 Mar;32(3):386-94 [18302722] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1530-0277.2008.00806.x ER - TY - JOUR T1 - The role of incretins in glucose homeostasis and diabetes treatment. AN - 69921890; 19074620 AB - Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within minutes after eating. One of their many physiological roles is to regulate the amount of insulin that is secreted after eating. In this manner, as well as others to be described in this review, their final common raison d'être is to aid in disposal of the products of digestion. There are two incretins, known as glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), that share many common actions in the pancreas but have distinct actions outside of the pancreas. Both incretins are rapidly deactivated by an enzyme called dipeptidyl peptidase 4 (DPP4). A lack of secretion of incretins or an increase in their clearance are not pathogenic factors in diabetes. However, in type 2 diabetes (T2DM), GIP no longer modulates glucose-dependent insulin secretion, even at supraphysiological (pharmacological) plasma levels, and therefore GIP incompetence is detrimental to beta-cell function, especially after eating. GLP-1, on the other hand, is still insulinotropic in T2DM, and this has led to the development of compounds that activate the GLP-1 receptor with a view to improving insulin secretion. Since 2005, two new classes of drugs based on incretin action have been approved for lowering blood glucose levels in T2DM: an incretin mimetic (exenatide, which is a potent long-acting agonist of the GLP-1 receptor) and an incretin enhancer (sitagliptin, which is a DPP4 inhibitor). Exenatide is injected subcutaneously twice daily and its use leads to lower blood glucose and higher insulin levels, especially in the fed state. There is glucose-dependency to its insulin secretory capacity, making it unlikely to cause low blood sugars (hypoglycemia). DPP4 inhibitors are orally active and they increase endogenous blood levels of active incretins, thus leading to prolonged incretin action. The elevated levels of GLP-1 are thought to be the mechanism underlying their blood glucose-lowering effects. JF - Pharmacological reviews AU - Kim, Wook AU - Egan, Josephine M AD - National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 470 EP - 512 VL - 60 IS - 4 KW - Hypoglycemic Agents KW - 0 KW - Incretins KW - Peptides KW - Pyrazines KW - Triazoles KW - Venoms KW - exenatide KW - 9P1872D4OL KW - Glucose KW - IY9XDZ35W2 KW - Sitagliptin Phosphate KW - TS63EW8X6F KW - Index Medicus KW - Hypoglycemic Agents -- therapeutic use KW - Animals KW - Venoms -- therapeutic use KW - Pyrazines -- therapeutic use KW - Humans KW - Triazoles -- therapeutic use KW - Peptides -- therapeutic use KW - Glucose -- metabolism KW - Incretins -- physiology KW - Homeostasis -- physiology KW - Diabetes Mellitus -- physiopathology KW - Diabetes Mellitus -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69921890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+reviews&rft.atitle=The+role+of+incretins+in+glucose+homeostasis+and+diabetes+treatment.&rft.au=Kim%2C+Wook%3BEgan%2C+Josephine+M&rft.aulast=Kim&rft.aufirst=Wook&rft.date=2008-12-01&rft.volume=60&rft.issue=4&rft.spage=470&rft.isbn=&rft.btitle=&rft.title=Pharmacological+reviews&rft.issn=1521-0081&rft_id=info:doi/10.1124%2Fpr.108.000604 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-12-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 2004 Aug;127(2):546-58 [15300587] Circulation. 2004 Aug 24;110(8):955-61 [15313949] Diabetes. 2004 Sep;53(9):2492-500 [15331566] Diabetes Care. 2004 Nov;27(11):2628-35 [15504997] Diabetes. 2004 Nov;53(11):2824-35 [15504962] J Clin Invest. 1967 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[10611300] Endocrinology. 2000 Feb;141(2):752-62 [10650957] Life Sci. 2000;66(2):91-103 [10666005] Endocrinology. 2000 Mar;141(3):1228-35 [10698200] Biochem Biophys Res Commun. 2000 Mar 16;269(2):331-5 [10708552] J Med Chem. 2000 May 4;43(9):1664-9 [10794683] Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1010-8 [10827002] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9 [10823914] Diabetes. 2000 May;49(5):741-8 [10905482] Diabetes. 2000 Jul;49(7):1156-64 [10909973] J Biol Chem. 2000 Sep 8;275(36):27989-99 [10869353] Biochem Pharmacol. 2002 Mar 1;63(5):993-6 [11911852] Diabetologia. 2002 Feb;45(2):195-202 [11935150] Exp Eye Res. 2002 Feb;74(2):231-6 [11950233] Bone. 2002 May;30(5):655-63 [11996901] Endocrinology. 2002 Jun;143(6):2303-13 [12021195] Endocrinology. 2002 Jun;143(6):2420-6 [12021207] J Endocrinol. 2002 Jun;173(3):465-73 [12065236] Nat Med. 2002 Jul;8(7):738-42 [12068290] J Clin Invest. 2002 Jul;110(1):43-52 [12093887] Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7 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Mar;145(3):1349-55 [14630721] Circulation. 2004 Mar 2;109(8):962-5 [14981009] Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E621-5 [14678954] J Endocrinol. 2004 Mar;180(3):389-98 [15012593] Nat Cell Biol. 2004 Mar;6(3):207-14 [15039777] Diabetes. 2004 May;53(5):1326-35 [15111503] Endocrinology. 2004 Jun;145(6):2687-95 [15001546] Diabetes Care. 2004 Jun;27(6):1335-42 [15161785] Diabetologia. 2004 May;47(5):806-15 [15095038] Diabetes Care. 2004 Jul;27(7):1692-8 [15220248] Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E199-206 [15271645] Bone. 2007 May;40(5):1352-60 [17321229] Int J Mol Med. 2007 Jun;19(6):961-6 [17487430] Gastroenterology. 2007 May;132(6):2131-57 [17498508] Diabetes. 2007 Jun;56(6):1551-8 [17360984] Diabetes. 2007 Jun;56(6):1671-9 [17369525] Diabetes Care. 2007 Jun;30(6):1487-93 [17353504] Diabetes Care. 2007 Jun;30(6):1608-10 [17372153] Eur J Clin Pharmacol. 2007 Jul;63(7):677-86 [17486328] Clin Pharmacokinet. 2007;46(7):577-88 [17596103] JAMA. 2007 Jul 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Endocrinology. 1985 Sep;117(3):817-23 [2862020] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/pr.108.000604 ER - TY - JOUR T1 - Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore. AN - 69916144; 19006141 AB - A search query consisting of two aromatic centers and two cationic centers was defined based on previously identified small molecule inhibitors of the botulinum neurotoxin serotype A light chain (BoNT/A LC) and used to mine the National Cancer Institute Open Repository. Ten small molecule hits were identified, and upon testing, three demonstrated inhibitory activity. Of these, one was structurally unique, possessing a rigid diazachrysene scaffold. The steric limitations of the diazachrysene imposed a separation between the overlaps of previously identified inhibitors, revealing an extended binding mode. As a result, the pharmacophore for BoNT/A LC inhibition has been modified to encompass three zones. To demonstrate the utility of this model, a novel three-zone inhibitor was mined and its activity was confirmed. JF - ChemMedChem AU - Hermone, Ann R AU - Burnett, James C AU - Nuss, Jonathan E AU - Tressler, Lyal E AU - Nguyen, Tam L AU - Solaja, Bogdan A AU - Vennerstrom, Jonathan L AU - Schmidt, James J AU - Wipf, Peter AU - Bavari, Sina AU - Gussio, Rick AD - Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc. National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1905 EP - 1912 VL - 3 IS - 12 KW - Chrysenes KW - 0 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Imaging, Three-Dimensional KW - Computer Simulation KW - Databases, Factual KW - Drug Design KW - Structure-Activity Relationship KW - Models, Molecular KW - Chrysenes -- pharmacology KW - Chrysenes -- chemistry KW - Botulinum Toxins, Type A -- antagonists & inhibitors KW - Botulinum Toxins, Type A -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69916144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ChemMedChem&rft.atitle=Three-dimensional+database+mining+identifies+a+unique+chemotype+that+unites+structurally+diverse+botulinum+neurotoxin+serotype+A+inhibitors+in+a+three-zone+pharmacophore.&rft.au=Hermone%2C+Ann+R%3BBurnett%2C+James+C%3BNuss%2C+Jonathan+E%3BTressler%2C+Lyal+E%3BNguyen%2C+Tam+L%3BSolaja%2C+Bogdan+A%3BVennerstrom%2C+Jonathan+L%3BSchmidt%2C+James+J%3BWipf%2C+Peter%3BBavari%2C+Sina%3BGussio%2C+Rick&rft.aulast=Hermone&rft.aufirst=Ann&rft.date=2008-12-01&rft.volume=3&rft.issue=12&rft.spage=1905&rft.isbn=&rft.btitle=&rft.title=ChemMedChem&rft.issn=1860-7187&rft_id=info:doi/10.1002%2Fcmdc.200800241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cmdc.200800241 ER - TY - JOUR T1 - Cognitive remediation in the treatment of stimulant abuse disorders: a research agenda. AN - 69901640; 19086769 AB - Treatment of substance abuse disorders is often characterized by high dropout rates. Patients who fail to complete a treatment course often are worse at follow-up than those patients who received the full treatment course. Cognitive deficits, including impulsivity, have been noted as a major determinant of treatment retention and successful outcomes. This review summarizes the recent literature on cognitive deficits in stimulant users and their remediation. Cognitive deficits can be remediated through computer-assisted cognitive rehabilitation in residential settings. A few studies have shown this can be transferred to the outpatient setting although much research remains to be done in this setting. Pharmacological remediation of cognitive deficits is a new target for medications development in the treatment of substance abuse disorders. Psychiatric disorders; for example, attention deficit hyperactivity disorder, are amenable to pharmacological remediation of cognitive deficits. Several cognitive deficits (set-shifting, attentional bias, reversal learning, impulsivity, and risky decision making) and their possible remediation with pharmacological agents are presented in the review. Recommendations for the research agenda include comments on testing hierarchies, clinical trial design issues, and types of pharmacological agents. (c) 2008 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Vocci, Frank J AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA. fvocci@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 484 EP - 497 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Central Nervous System Stimulants KW - 0 KW - Index Medicus KW - Impulsive Behavior -- complications KW - Humans KW - Patient Dropouts KW - Treatment Outcome KW - Impulsive Behavior -- therapy KW - Central Nervous System Stimulants -- adverse effects KW - Therapy, Computer-Assisted -- methods KW - Cognitive Therapy -- methods KW - Substance-Related Disorders -- physiopathology KW - Cognition Disorders -- therapy KW - Substance-Related Disorders -- rehabilitation KW - Cognition Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69901640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Cognitive+remediation+in+the+treatment+of+stimulant+abuse+disorders%3A+a+research+agenda.&rft.au=Vocci%2C+Frank+J&rft.aulast=Vocci&rft.aufirst=Frank&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014101 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1037/a0014101 ER - TY - JOUR T1 - Introduction to a symposium on recent advances in the development of medications for drug abuse treatment in honor of Jack H. Mendelson, M.D. AN - 69901562; 19086765 JF - Experimental and clinical psychopharmacology AU - Acri, Jane B AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA. jacri@nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 443 EP - 445 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Index Medicus KW - Mendelson KW - History, 21st Century KW - History, 20th Century KW - Humans KW - Clinical Trials as Topic KW - Male KW - Alcoholism -- rehabilitation KW - Alcoholism -- history KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69901562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Introduction+to+a+symposium+on+recent+advances+in+the+development+of+medications+for+drug+abuse+treatment+in+honor+of+Jack+H.+Mendelson%2C+M.D.&rft.au=Acri%2C+Jane+B&rft.aulast=Acri&rft.aufirst=Jane&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014102 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - People - Mendelson N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Mendelson DO - http://dx.doi.org/10.1037/a0014102 ER - TY - JOUR T1 - Dual dopamine/serotonin releasers: potential treatment agents for stimulant addiction. AN - 69897932; 19086767 AB - "Agonist therapy" for cocaine and methamphetamine addiction involves administration of stimulant-like medications (e.g., monoamine releasers) to reduce withdrawal symptoms and prevent relapse. A significant problem with this strategy is that many candidate medications possess abuse liability because of activation of mesolimbic dopamine (DA) neurons in the brain. One way to reduce DA-mediated abuse liability of candidate drugs is to add in serotonin (5-HT) releasing properties, since substantial evidence shows that 5-HT neurons provide an inhibitory influence over mesolimbic DA neurons. This article addresses several key issues related to the development of dual DA/5-HT releasers for the treatment of substance use disorders. First, the authors briefly summarize the evidence supporting a dual deficit in DA and 5-HT function during withdrawal from chronic cocaine or alcohol abuse. Second, the authors discuss data demonstrating that 5HT release can dampen DA-mediated stimulant effects, and the "antistimulant" role of 5-HT-sub(2C) receptors is considered. Next, the mechanisms underlying potential adverse effects of 5-HT releasers are described. Finally, the authors discuss recently published data with PAL-287, a novel nonamphetamine DA/5-HT releasing agent that suppresses cocaine self-administration but lacks positive reinforcing properties. It is concluded that DA/5-HT releasers could be useful therapeutic adjuncts for the treatment of cocaine and alcohol addictions, as well as for obesity, attention-deficit disorder, and depression. (c) 2008 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Rothman, Richard B AU - Blough, Bruce E AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, IRP/NIDA/NIH, Clinical Psychopharmacology Section, Suite 4500, Triad Building, 333 Cassell Drive, Baltimore, MD 21224, USA. rrothman@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 458 EP - 474 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Central Nervous System Stimulants KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Humans KW - Cocaine-Related Disorders -- drug therapy KW - Dopamine -- metabolism KW - Behavior, Addictive -- drug therapy KW - Serotonin -- metabolism KW - Substance-Related Disorders -- physiopathology KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance-Related Disorders -- drug therapy KW - Substance Withdrawal Syndrome -- drug therapy KW - Central Nervous System Stimulants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69897932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Dual+dopamine%2Fserotonin+releasers%3A+potential+treatment+agents+for+stimulant+addiction.&rft.au=Rothman%2C+Richard+B%3BBlough%2C+Bruce+E%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014103 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Heart Valve Dis. 2000 May;9(3):454-8 [10888105] Psychopharmacology 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[11071707] Chest. 2000 Nov;118(5):1496-7 [11083709] Neuroscience. 2007 Apr 25;146(1):286-97 [17367945] Neuroscience. 2007 Jun 8;146(4):1677-88 [17467185] Curr Opin Neurobiol. 2007 Jun;17(3):304-12 [17509873] Trends Pharmacol Sci. 2007 Jul;28(7):316-25 [17573127] Am J Cardiol. 2007 Nov 1;100(9):1442-5 [17950805] Neuropsychopharmacology. 2008 Jan;33(1):166-80 [17805308] J Pharmacol Exp Ther. 2008 Feb;324(2):791-7 [18032571] Am J Ther. 2010 Nov-Dec;17(6):596-603 [19352140] Br J Pharmacol. 1997 Dec;122(7):1455-63 [9421295] Pharmacol Biochem Behav. 1998 Mar;59(3):709-15 [9512076] Alcohol Clin Exp Res. 1998 Feb;22(1):3-9 [9514280] Am J Addict. 1998 Spring;7(2):142-55 [9598218] Ann N Y Acad Sci. 1998 May 30;844:59-74 [9668665] Synapse. 1998 Sep;30(1):107-11 [9704887] Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):87-96 [9716932] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1037/a0014103 ER - TY - JOUR T1 - Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs. AN - 69892991; 19075617 AB - Medicinal use of natural products such as extracts of plants has existed for many years in China and in other countries and they are now available worldwide. Citrus fruit juices are consumed on a daily basis around the world. Modern medicine provides well-tested compounds or drugs for most sicknesses. However, the simultaneous consumption of plant extracts, food supplements, and fruit juices with drugs can create metabolic aberrations in humans. Interactions between drugs used simultaneously are regulated by government agencies. Not regulated, but warned against in drug inserts are potential interactions between drugs and food and food-additives containing certain compounds with potential side effects. Summarized here are the results of investigations that point out possible interactions at the level of transporter molecules by drugs and compounds of natural origin. These transporter molecules play important roles in absorption in the intestines, at the blood brain barrier, in the liver, the kidney and in some other parts of the human body. Drugs and metabolites pass through these pumps and may compete with compounds from food supplements. The most studied natural compounds that are potential modulators of these transport molecules are flavonoids, found in fruit juices, vegetables, flowers and tea. Mycotoxins found in cereal grains are also shown to modulate transporter proteins. We detail here how such constituents of natural origin were shown to modulate three types of the major transporter molecules, P-glycoprotein (ABCB1), multidrug resistance proteins (ABCCs) and breast cancer resistance protein (ABCG2). Interference of these natural compounds with drugs at the transporter level is also discussed. JF - Current drug metabolism AU - Aszalos, Adorjan AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Room 2112, Bethesda, MD 20892, USA. aszalosa@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1010 EP - 1018 VL - 9 IS - 10 SN - 1389-2002, 1389-2002 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Multidrug Resistance-Associated Proteins KW - Neoplasm Proteins KW - P-Glycoprotein KW - multidrug resistance-associated protein 2 KW - 4AF605U6JN KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Multidrug Resistance-Associated Proteins -- physiology KW - P-Glycoprotein -- physiology KW - Neoplasm Proteins -- physiology KW - Humans KW - Citrus paradisi KW - ATP-Binding Cassette Transporters -- physiology KW - Food-Drug Interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69892991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+metabolism&rft.atitle=Role+of+ATP-binding+cassette+%28ABC%29+transporters+in+interactions+between+natural+products+and+drugs.&rft.au=Aszalos%2C+Adorjan&rft.aulast=Aszalos&rft.aufirst=Adorjan&rft.date=2008-12-01&rft.volume=9&rft.issue=10&rft.spage=1010&rft.isbn=&rft.btitle=&rft.title=Current+drug+metabolism&rft.issn=13892002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metal catalyzed oxidation of alpha-synuclein--a role for oligomerization in pathology? AN - 69891950; 19075587 AB - A number of studies have demonstrated a role for transition metals and oxidative stress in the etiology of Parkinson's disease (PD). Genetic and biochemical evidence also clearly links the protein alpha-synuclein (alphaSyn) to PD and a number of associated diseases. In these "synucleinopathies", alphaSyn is deposited, often in oligomerized forms, as cytoplasmic inclusions known as Lewy bodies and Lewy neurites. alphaSyn cross-linking/oligomerization can occur via a number of processes, most stimulated by metal catalyzed oxidation (MCO). In PD, the increased sensitivity of midbrain neurons expressing high levels of oxidizable catecholamines may provide one clue to account for degeneration of these neurons. In other regions of the nervous system that develop Lewy body pathology, the mode of alphaSyn oligomerization is less clear. Thus, the relationship between alphaSyn and MCO, either direct or indirect, represents a particular concern for possible treatment of these various diseases. JF - Current Alzheimer research AU - Cole, N B AD - Laboratory of Biochemistry, National Heart Lung and Blood Institute, 50 South Drive MSC 8012, Bethesda, Maryland 20892, USA. ncole@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 599 EP - 606 VL - 5 IS - 6 SN - 1567-2050, 1567-2050 KW - Metals KW - 0 KW - alpha-Synuclein KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Humans KW - Brain Chemistry -- drug effects KW - Lipid Peroxidation -- drug effects KW - Catalysis KW - Brain Chemistry -- physiology KW - alpha-Synuclein -- chemistry KW - Neurodegenerative Diseases -- metabolism KW - alpha-Synuclein -- toxicity KW - Neurodegenerative Diseases -- pathology KW - Metals -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69891950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=Metal+catalyzed+oxidation+of+alpha-synuclein--a+role+for+oligomerization+in+pathology%3F&rft.au=Cole%2C+N+B&rft.aulast=Cole&rft.aufirst=N&rft.date=2008-12-01&rft.volume=5&rft.issue=6&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=15672050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. AN - 69891348; 19075603 AB - Glucocerebrosidase (GC) catalyzes the hydrolysis of beta-glucocerebroside to glucose and ceramide in lysosomes. Mutations in the glucocerebrosidase gene (GBA) result in Gaucher disease, an autosomal recessive lysosomal storage disorder. Many of the mutations encountered in patients with Gaucher disease are missense alterations that may cause misfolding, decreased stability and/or mistrafficking of this lysosomal protein. Some inhibitors of GC have been shown to act as chemical chaperones, stabilizing the conformation of mutant proteins and thus restoring their function. High throughput screening (HTS) of small molecule libraries for such compounds with potential for chaperone therapy requires an accurate, reproducible and sensitive assay method. We have adapted and optimized two fluorogenic GC enzyme assays and miniaturized them into the 1536-well plate format for HTS. The two substrates, 4-methylumbelliferyl beta-D-glucopyranoside and resorufin beta-D-glucopyranoside, have K(m) values of 768 microM and 33 microM, respectively, and different emission spectra. Paired screening with the two assays helps to eliminate false inference of activity due to autofluorescence or fluorescence quenching by the screened compounds. Test screens with the LOPAC library indicated that both assays were robust for HTS, and gave comparable results for GC inhibitor activities. These two assays can be used to identify both GC activators and inhibitors with potential therapeutic value. JF - Combinatorial chemistry & high throughput screening AU - Urban, Daniel J AU - Zheng, Wei AU - Goker-Alpan, Ozlem AU - Jadhav, Ajit AU - Lamarca, Mary E AU - Inglese, James AU - Sidransky, Ellen AU - Austin, Christopher P AD - Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3708, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 817 EP - 824 VL - 11 IS - 10 SN - 1386-2073, 1386-2073 KW - Enzyme Inhibitors KW - 0 KW - Taurocholic Acid KW - 5E090O0G3Z KW - Glucosylceramidase KW - EC 3.2.1.45 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Spectrometry, Fluorescence KW - Kinetics KW - Hydrogen-Ion Concentration KW - Enzyme Inhibitors -- pharmacology KW - Miniaturization KW - Substrate Specificity KW - Inhibitory Concentration 50 KW - Glucosylceramidase -- analysis KW - Glucosylceramidase -- metabolism KW - Glucosylceramidase -- antagonists & inhibitors KW - Drug Evaluation, Preclinical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69891348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Combinatorial+chemistry+%26+high+throughput+screening&rft.atitle=Optimization+and+validation+of+two+miniaturized+glucocerebrosidase+enzyme+assays+for+high+throughput+screening.&rft.au=Urban%2C+Daniel+J%3BZheng%2C+Wei%3BGoker-Alpan%2C+Ozlem%3BJadhav%2C+Ajit%3BLamarca%2C+Mary+E%3BInglese%2C+James%3BSidransky%2C+Ellen%3BAustin%2C+Christopher+P&rft.aulast=Urban&rft.aufirst=Daniel&rft.date=2008-12-01&rft.volume=11&rft.issue=10&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=Combinatorial+chemistry+%26+high+throughput+screening&rft.issn=13862073&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-09 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15428-33 [12434014] Hum Mutat. 2008 May;29(5):567-83 [18338393] Mol Genet Metab. 2004 Sep-Oct;83(1-2):6-15 [15464415] Clin Chim Acta. 1975 May 1;60(3):391-6 [806404] Clin Chim Acta. 1976 Jul 15;70(2):247-57 [8226] Arch Biochem Biophys. 1976 Aug;175(2):569-82 [958319] Brain Res. 1977 Feb 18;122(2):325-35 [13910] Clin Chim Acta. 1978 Oct 16;89(2):293-9 [361294] Biochem J. 1980 Mar 1;185(3):583-91 [7387624] Clin Chem. 1982 Apr;28(4 Pt 1):569-77 [6804115] Anal Biochem. 1983 Apr 15;130(2):521-6 [6869839] Biochemistry. 1985 Jul 2;24(14):3530-9 [3929833] J Neurochem. 1990 Feb;54(2):699-702 [1967633] Cell Biochem Funct. 1993 Sep;11(3):167-77 [8403230] Agents Actions. 1993 Nov;40(3-4):186-90 [8023742] Biochim Biophys Acta. 1994 Jul 14;1213(2):176-82 [8025128] Anal Biochem. 1997 May 1;247(2):268-71 [9177687] Baillieres Clin Haematol. 1997 Dec;10(4):621-34 [9497855] Hepatology. 1998 Jul;28(1):156-63 [9657108] J Pathol. 1999 Aug;188(4):407-14 [10440752] J Biol Chem. 2005 Jun 24;280(25):23815-9 [15817452] Hum Mol Genet. 2005 Aug 15;14(16):2387-98 [16000318] Blood Cells Mol Dis. 2005 Sep-Oct;35(2):268-76 [16039881] J Biomol Screen. 2006 Feb;11(1):29-39 [16234337] Cell Mol Life Sci. 2006 May;63(10):1179-92 [16568247] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Nat Chem Biol. 2007 Feb;3(2):101-7 [17187079] Mol Genet Metab. 2007 Feb;90(2):122-5 [17084653] Expert Opin Pharmacother. 2007 Mar;8(4):427-35 [17309337] J Biomol Screen. 2007 Mar;12(2):203-10 [17208922] Nat Chem Biol. 2007 Aug;3(8):466-79 [17637779] Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7 [17670938] Trends Pharmacol Sci. 2003 Jul;24(7):355-60 [12871668] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical evaluation of paroxetine in post-traumatic stress disorder (PTSD): 52-week, non-comparative open-label study for clinical use experience. AN - 69876631; 19068000 AB - The present study was a 52-week, non-comparative, open-label study of flexible dose paroxetine (20-40 mg) in 52 Japanese post-traumatic stress disorder (PTSD) patients in order to obtain clinical experience regarding efficacy and safety in regular clinical practice. Efficacy was measured using the Clinician-Administered PTSD Scale One Week Symptom Status Version (CAPS-SX). The mean change from baseline in CAPS-SX total score was -19.1, -22.8 and -32.3 at weeks 4, 12 and 52, respectively, and that in the Clinical Global Impression (CGI) Severity of Illness score was -1.1 at week 12 and -1.7 at week 52. A total of 46.9% were CGI responders at week 12, while 67.3% were improved on the CGI at week 52. Of 52 subjects who entered into the drug treatment, 25 completed the study. Only one patient withdrew from the study due to lack of efficacy. In patients who were rated as 'moderately ill' or less at baseline, the proportion of CGI responders at end-point was higher at a dose of 20 mg/day than at higher doses, whereas in patients rated as 'markedly ill' or more, it was higher at 30 and 40 mg/day, suggesting that severely ill patients could benefit from higher doses. Paroxetine appeared generally tolerated in short- and long-term use, and the safety profile in this study was consistent with international trials and other Japanese populations (i.e. patients suffering from depression, panic disorder or obsessive-compulsive disorder). Although the study was not conducted in double-blind fashion, the current findings suggest that paroxetine may contribute to clinically meaningful improvement that is maintained during long-term use and is generally well tolerated. JF - Psychiatry and clinical neurosciences AU - Kim, Yoshiharu AU - Asukai, Nozomu AU - Konishi, Takako AU - Kato, Hiroshi AU - Hirotsune, Hideto AU - Maeda, Masaharu AU - Inoue, Hirotaka AU - Narita, Hiroyasu AU - Iwasaki, Masaru AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 646 EP - 652 VL - 62 IS - 6 KW - Serotonin Uptake Inhibitors KW - 0 KW - Paroxetine KW - 41VRH5220H KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Treatment Outcome KW - Cluster Analysis KW - Male KW - Female KW - Paroxetine -- administration & dosage KW - Serotonin Uptake Inhibitors -- administration & dosage KW - Stress Disorders, Post-Traumatic -- psychology KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Paroxetine -- therapeutic use KW - Paroxetine -- adverse effects KW - Stress Disorders, Post-Traumatic -- drug therapy KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69876631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+and+clinical+neurosciences&rft.atitle=Clinical+evaluation+of+paroxetine+in+post-traumatic+stress+disorder+%28PTSD%29%3A+52-week%2C+non-comparative+open-label+study+for+clinical+use+experience.&rft.au=Kim%2C+Yoshiharu%3BAsukai%2C+Nozomu%3BKonishi%2C+Takako%3BKato%2C+Hiroshi%3BHirotsune%2C+Hideto%3BMaeda%2C+Masaharu%3BInoue%2C+Hirotaka%3BNarita%2C+Hiroyasu%3BIwasaki%2C+Masaru&rft.aulast=Kim&rft.aufirst=Yoshiharu&rft.date=2008-12-01&rft.volume=62&rft.issue=6&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Psychiatry+and+clinical+neurosciences&rft.issn=1440-1819&rft_id=info:doi/10.1111%2Fj.1440-1819.2008.01862.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1819.2008.01862.x ER - TY - JOUR T1 - K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3'-azido-3'-deoxythymidine. AN - 69875691; 18800350 AB - A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program,2006]. The incidence of alveolar/bronchiolar adenomas and carcinomas in the 200 and 300 mg/kg groups was significantly higher (P = 0.027 and 0.007, respectively) in male offspring, but not in females (P = 0.338 and 0.315, respectively). The purpose of the present study was to evaluate K-ras mutation status in lung tumors from the female offspring in AZT exposed groups and to determine whether at the molecular level there were signature K-ras mutations in lung tumors that were different from spontaneous tumors. K-ras mutation was detected by cycle sequencing of polymerase chain reaction (PCR)-amplified DNA, isolated from formalin-fixed, paraffin-embedded lung tumors. K-ras mutations were detected in 17 of 28 (61%) lung tumors from the female offspring in AZT exposed groups. No K-ras mutations were detected in the 8 tumors examined from the female control group. The predominant mutations were Codon 12 G-->T transversions in the 50, 100, and 300 mg/kg groups, and Codon 12 G-->C transversions in the 200 and 300 mg/kg groups. K-ras Codon 12 G-->T transversions (TGT mutations) may be induced by oxidative DNA damage and 8-oxoguanine (8-oxoG), while K-ras Codon 12 G-->C transversions (CGT mutations) may be due to further oxidative lesions of guanine and 8-oxoG. JF - Environmental and molecular mutagenesis AU - Koujitani, Takatoshi AU - Ton, Tai-Vu T AU - Lahousse, Stephanie A AU - Hong, Hue-Hua L AU - Wakamatsu, Nobuko AU - Sills, Robert C AD - Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 720 EP - 726 VL - 49 IS - 9 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - Maternal Exposure -- adverse effects KW - Prenatal Exposure Delayed Effects -- etiology KW - Animals KW - Sex Factors KW - Mice KW - Male KW - Female KW - Prenatal Exposure Delayed Effects -- genetics KW - Pregnancy KW - Mutation -- drug effects KW - Lung Neoplasms -- etiology KW - Zidovudine -- toxicity KW - Genes, ras -- genetics KW - Lung Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69875691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=K-ras+cancer+gene+mutations+in+lung+tumors+from+female+Swiss+%28CD-1%29+mice+exposed+transplacentally+to+3%27-azido-3%27-deoxythymidine.&rft.au=Koujitani%2C+Takatoshi%3BTon%2C+Tai-Vu+T%3BLahousse%2C+Stephanie+A%3BHong%2C+Hue-Hua+L%3BWakamatsu%2C+Nobuko%3BSills%2C+Robert+C&rft.aulast=Koujitani&rft.aufirst=Takatoshi&rft.date=2008-12-01&rft.volume=49&rft.issue=9&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20420 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20420 ER - TY - JOUR T1 - Correlates of human papillomavirus viral load with infection site in asymptomatic men. AN - 69872936; 19064573 AB - Numerous studies have evaluated human papillomavirus (HPV) DNA load in women, especially HPV-16 viral load, and its role in cervical carcinogenicity. Few studies have examined HPV viral load in men, none among asymptomatic men. The aim of the current study is to quantify HPV-16 viral load in male anogenital specimens and to explore its correlates with anatomic sites. Two-hundred and ninety-four specimens from 42 men who tested positive for HPV-16 at one or more anatomic sites were evaluated. HPV DNA was detected with PGMY 09/11 primer and genotyped with reverse line blot assay followed by HPV-16 viral quantification using type-specific real-time PCR assay (TaqMan). The quantitative PCR assay showed a higher sensitivity in HPV-16 viral DNA detection compared with the reverse line blot assay. Viral load varied significantly by anatomic site (P = 0.019). Penile shaft specimens had significantly higher viral load than any other anatomic site evaluated except for the anal canal. HPV-16 viral load was positively correlated between proximal anatomic sites: perianal and anal canal (P = 0.003), perianal and scrotum (P = 0.011), scrotum and glans/corona (P = 0.045), and scrotum and penile shaft (P = 0.037). In conclusion, the penile shaft seemed to be the preferred site for HPV-16 viral replication. Viral load correlation between proximal sites suggested a possible autoinoculation in male HPV transmission. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Flores, Roberto AU - Lu, Beibei AU - Beibei, Lu AU - Nielson, Carrie AU - Abrahamsen, Martha AU - Wolf, Kyle AU - Lee, Ji-Hyun AU - Harris, Robin B AU - Giuliano, Anna R AD - Cancer Prevention Fellowship Program, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS Suite T-41, Bethesda, MD 20892-7105, USA. rflores@jhsph.edu Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3573 EP - 3576 VL - 17 IS - 12 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Virus Replication KW - Viral Load KW - Sensitivity and Specificity KW - Genotype KW - Cross-Sectional Studies KW - Penis -- virology KW - Humans KW - Adult KW - Reverse Transcriptase Polymerase Chain Reaction KW - Statistics, Nonparametric KW - Male KW - Human papillomavirus 16 -- isolation & purification KW - Papillomavirus Infections -- virology KW - Human papillomavirus 16 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69872936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Correlates+of+human+papillomavirus+viral+load+with+infection+site+in+asymptomatic+men.&rft.au=Flores%2C+Roberto%3BLu%2C+Beibei%3BBeibei%2C+Lu%3BNielson%2C+Carrie%3BAbrahamsen%2C+Martha%3BWolf%2C+Kyle%3BLee%2C+Ji-Hyun%3BHarris%2C+Robin+B%3BGiuliano%2C+Anna+R&rft.aulast=Flores&rft.aufirst=Roberto&rft.date=2008-12-01&rft.volume=17&rft.issue=12&rft.spage=3573&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0467 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):216 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0467 ER - TY - JOUR T1 - High incidence of oral dysesthesias on a trial of gefitinib, Paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers. AN - 69871530; 19060587 AB - To report a high incidence of oral mucosal dysesthesia occurring in patients on a pilot study of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa) in combination with paclitaxel (Taxol) and external beam radiation therapy for the treatment of locally advanced squamous cell carcinoma of the head and neck. Nine patients were enrolled on a pilot phase I trial of oral gefitinib 250 mg/d with 6 weekly doses of paclitaxel (36 or 45 mg/m) and concurrent radiation therapy [66-76 Gray (Gy)]. All had stage III/IVA-B squamous cell carcinoma of the head and neck. Patients were evaluated twice weekly by physicians and daily by nursing for adverse events. Six of 9 patients (67%) developed a grade 3 "burning" quality oral dysesthesia. These patients received at least 50 Gy (range 50-70 Gy) to the oral tongue. The patients without grade 3 oral dysesthesia received less than 50 Gy radiation to the oral tongue. The oral dysesthesia was exacerbated by the ingestion of neutral pH liquids such as water. Of the 6 patients, all eventually developed common toxicity criteria grade 3/4 mucositis; however, symptoms continued after resolution of the mucositis. Gabapentin (Neurontin) was administered to 2 patients as a treatment for painful mucosal neuropathy. Both patients had near resolution of symptoms despite the evolution of oral mucositis. Development of "burning"-type oral dysesthesia occurred in patients treated with the combination of gefitinib, paclitaxel, and external beam radiation of the oral tongue. This dysesthesia was improved by the use of gabapentin. JF - American journal of clinical oncology AU - Sharp, Hadley AU - Morris, John C AU - Van Waes, Carter AU - Gius, David AU - Cooley-Zgela, Theresa AU - Singh, Anurag K AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 557 EP - 560 VL - 31 IS - 6 KW - Amines KW - 0 KW - Anticonvulsants KW - Cyclohexanecarboxylic Acids KW - Quinazolines KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - gabapentin KW - 6CW7F3G59X KW - Paclitaxel KW - P88XT4IS4D KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Prognosis KW - Aged KW - Amines -- therapeutic use KW - Cyclohexanecarboxylic Acids -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Quinazolines -- administration & dosage KW - gamma-Aminobutyric Acid -- therapeutic use KW - Adult KW - Incidence KW - Middle Aged KW - Female KW - Male KW - Radiation Injuries -- drug therapy KW - Paresthesia -- chemically induced KW - Head and Neck Neoplasms -- pathology KW - Paresthesia -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Stomatitis -- drug therapy KW - Head and Neck Neoplasms -- drug therapy KW - Radiotherapy -- adverse effects KW - Stomatitis -- chemically induced KW - Head and Neck Neoplasms -- therapy KW - Carcinoma, Squamous Cell -- pathology KW - Head and Neck Neoplasms -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy KW - Radiation Injuries -- etiology KW - Carcinoma, Squamous Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69871530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=High+incidence+of+oral+dysesthesias+on+a+trial+of+gefitinib%2C+Paclitaxel%2C+and+concurrent+external+beam+radiation+for+locally+advanced+head+and+neck+cancers.&rft.au=Sharp%2C+Hadley%3BMorris%2C+John+C%3BVan+Waes%2C+Carter%3BGius%2C+David%3BCooley-Zgela%2C+Theresa%3BSingh%2C+Anurag+K&rft.aulast=Sharp&rft.aufirst=Hadley&rft.date=2008-12-01&rft.volume=31&rft.issue=6&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=1537-453X&rft_id=info:doi/10.1097%2FCOC.0b013e318172d5de LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-13 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/COC.0b013e318172d5de ER - TY - JOUR T1 - Small toxic proteins and the antisense RNAs that repress them. AN - 69866027; 19052321 AB - There has been a great expansion in the number of small regulatory RNAs identified in bacteria. Some of these small RNAs repress the synthesis of potentially toxic proteins. Generally the toxin proteins are hydrophobic and less than 60 amino acids in length, and the corresponding antitoxin small RNA genes are antisense to the toxin genes or share long stretches of complementarity with the target mRNAs. Given their short length, only a limited number of these type I toxin-antitoxin loci have been identified, but it is predicted that many remain to be found. Already their characterization has given insights into regulation by small RNAs, has suggested functions for the small toxic proteins at the cell membrane, and has led to practical applications for some of the type I toxin-antitoxin loci. JF - Microbiology and molecular biology reviews : MMBR AU - Fozo, Elizabeth M AU - Hemm, Matthew R AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 18 Library Drive, Bethesda, MD 20892-5430, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 579 EP - 89, Table of Contents VL - 72 IS - 4 KW - Antitoxins KW - 0 KW - Bacterial Toxins KW - RNA, Antisense KW - RNA, Bacterial KW - Index Medicus KW - Antitoxins -- genetics KW - Enterobacteriaceae -- genetics KW - Chromosomes, Bacterial -- genetics KW - Enterobacteriaceae -- metabolism KW - Gene Expression Regulation, Bacterial KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- antagonists & inhibitors KW - Bacterial Toxins -- metabolism KW - RNA, Bacterial -- metabolism KW - RNA, Antisense -- metabolism KW - RNA, Bacterial -- genetics KW - RNA, Antisense -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69866027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+and+molecular+biology+reviews+%3A+MMBR&rft.atitle=Small+toxic+proteins+and+the+antisense+RNAs+that+repress+them.&rft.au=Fozo%2C+Elizabeth+M%3BHemm%2C+Matthew+R%3BStorz%2C+Gisela&rft.aulast=Fozo&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=72&rft.issue=4&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Microbiology+and+molecular+biology+reviews+%3A+MMBR&rft.issn=1098-5557&rft_id=info:doi/10.1128%2FMMBR.00025-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2008-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1999 Dec 17;294(5):1115-25 [10600370] Mol Microbiol. 2008 Dec;70(5):1076-93 [18710431] Mol Microbiol. 2000 Aug;37(3):652-60 [10931358] Mol Microbiol. 2000 Aug;37(3):661-70 [10931359] Curr Biol. 2001 Jun 26;11(12):941-50 [11448770] J Biol Chem. 2001 Sep 21;276(38):35707-13 [11461923] Mol Microbiol. 2001 Oct;42(2):527-37 [11703673] Mol Microbiol. 2002 Jul;45(2):333-49 [12123448] J Biotechnol. 2003 Jan 9;100(1):1-12 [12413781] Res Microbiol. 2002 Oct;153(8):493-501 [12437210] J Bacteriol. 2003 Apr;185(7):2169-77 [12644486] Br J Cancer. 2003 Jul 7;89(1):192-8 [12838323] Science. 2003 Sep 12;301(5639):1496-9 [12970556] Science. 1975 Jan 24;187(4173):257-8 [1089310] J Bacteriol. 1977 Dec;132(3):784-9 [336605] J Bacteriol. 1980 Nov;144(2):833-5 [6159347] Microbiol Immunol. 1982;26(9):779-93 [6185827] Biochim Biophys Acta. 1983 Jan 20;739(1):27-34 [6187365] J Bacteriol. 1985 Jan;161(1):292-8 [2981804] Proc Natl Acad Sci U S A. 1986 May;83(10):3116-20 [3517851] Biochim Biophys Acta. 1986 Jun 20;867(3):81-8 [2424508] EMBO J. 1986 Aug;5(8):2023-9 [3019679] Gene. 1988 Jun 30;66(2):259-68 [3049248] Mol Microbiol. 1990 Nov;4(11):1807-18 [1707122] New Biol. 1990 Nov;2(11):946-56 [2101633] Mol Microbiol. 1991 Jul;5(7):1627-37 [1943700] J Mol Biol. 1992 Jan 5;223(1):41-54 [1370544] Mol Microbiol. 1991 Aug;5(8):1961-73 [1722558] Mol Microbiol. 1992 Apr;6(7):895-905 [1602968] J Mol Biol. 1992 Aug 5;226(3):637-49 [1380562] Biotechnol Prog. 1994 Nov-Dec;10(6):621-9 [7765697] Plasmid. 1994 Sep;32(2):168-81 [7531349] J Bacteriol. 1996 Apr;178(7):2044-50 [8606182] Mol Microbiol. 1996 Apr;20(1):53-63 [8861204] Mol Microbiol. 1996 Sep;21(5):1049-60 [8885274] Appl Environ Microbiol. 1997 May;63(5):1917-24 [9143123] J Mol Biol. 1997 Oct 17;273(1):38-51 [9367744] Mol Microbiol. 1999 Jun;32(5):1090-102 [10361310] Curr Biol. 2004 Dec 29;14(24):2271-6 [15620655] Nucleic Acids Res. 2005;33(3):1040-50 [15718303] Nat Rev Microbiol. 2005 May;3(5):371-82 [15864262] J Bacteriol. 2005 Oct;187(19):6641-50 [16166525] Trends Biochem Sci. 2005 Dec;30(12):672-9 [16257530] J Bacteriol. 2006 Aug;188(15):5374-84 [16855226] Biochem J. 2006 Oct 1;399(1):1-7 [16956326] Nucleic Acids Res. 2006;34(20):5915-22 [17065468] Curr Opin Microbiol. 2007 Apr;10(2):117-24 [17376733] Curr Opin Microbiol. 2007 Apr;10(2):96-101 [17383222] Curr Opin Microbiol. 2007 Apr;10(2):134-9 [17383928] Curr Opin Microbiol. 2007 Apr;10(2):125-33 [17395525] Mol Microbiol. 2007 May;64(3):738-54 [17462020] Mol Cell. 2007 May 11;26(3):381-92 [17499044] Curr Opin Microbiol. 2007 Jun;10(3):257-61 [17553733] J Mol Microbiol Biotechnol. 2007;13(4):200-9 [17827970] Mol Microbiol. 2008 Oct;70(1):258-70 [18761622] Res Microbiol. 1999 Nov-Dec;150(9-10):653-64 [10673004] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MMBR.00025-08 ER - TY - JOUR T1 - Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation. AN - 69863815; 18701433 AB - Squamous cell carcinoma accounts for 20% of all human lung cancers and is strongly linked to cigarette smoking. It develops through premalignant changes that are characterized by high levels of keratin 14 (K14) expression in the airway epithelium and evolve through basal cell hyperplasia, squamous metaplasia and dysplasia to carcinoma in situ and invasive carcinoma. In order to explore the impact of K14 in the pulmonary epithelium that normally lacks both squamous differentiation and K14 expression, human keratin 14 gene hK14 was constitutively expressed in mouse airway progenitor cells using a mouse Clara cell specific 10 kDa protein (CC10) promoter. While the lungs of CC10-hK14 transgenic mice developed normally, we detected increased expression of K14 and the molecular markers of squamous differentiation program such as involucrin, loricrin, small proline-rich protein 1A, transglutaminase 1 and cholesterol sulfotransferase 2B1. In contrast, wild-type lungs were negative. Aging CC10-hK14 mice revealed multifocal airway cell hyperplasia, occasional squamous metaplasia and their lung tumors displayed evidence for multidirectional differentiation. We conclude that constitutive expression of hK14 initiates squamous differentiation program in the mouse lung, but fails to promote squamous maturation. Our study provides a novel model for assessing the mechanisms of premalignant lesions in vivo by modifying differentiation and proliferation of airway progenitor cells. JF - Carcinogenesis AU - Dakir, E L Habib AU - Feigenbaum, Lionel AU - Linnoila, R Ilona AD - Experimental Pathology Section, Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2377 EP - 2384 VL - 29 IS - 12 KW - KRT14 protein, human KW - 0 KW - Keratin-14 KW - Index Medicus KW - Animals KW - Blotting, Western KW - Transfection KW - Humans KW - Immunoprecipitation KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Transgenic KW - Immunohistochemistry KW - Keratin-14 -- genetics KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinoma, Squamous Cell -- metabolism KW - Precancerous Conditions -- metabolism KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- genetics KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- genetics KW - Lung Neoplasms -- genetics KW - Cell Transformation, Neoplastic -- genetics KW - Keratin-14 -- metabolism KW - Lung Neoplasms -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69863815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Constitutive+expression+of+human+keratin+14+gene+in+mouse+lung+induces+premalignant+lesions+and+squamous+differentiation.&rft.au=Dakir%2C+E+L+Habib%3BFeigenbaum%2C+Lionel%3BLinnoila%2C+R+Ilona&rft.aulast=Dakir&rft.aufirst=E+L&rft.date=2008-12-01&rft.volume=29&rft.issue=12&rft.spage=2377&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn190 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-28 N1 - Date created - 2008-12-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Cell Biol. 1990 Dec;2(6):1028-35 [1712211] Cancer Res. 1990 Jan 1;50(1):120-8 [1967140] Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;61(6):375-87 [1349777] J Natl Cancer Inst Monogr. 1992;(13):93-100 [1327037] Biochem Biophys Res Commun. 1993 Nov 30;197(1):163-71 [7916613] J Biol Chem. 1995 Feb 10;270(6):2689-94 [7852338] Cell Growth Differ. 1997 Feb;8(2):145-55 [9040936] J Cell Biol. 1998 Oct 19;143(2):487-99 [9786957] Gene. 1998 Dec 11;224(1-2):59-66 [9931436] Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L625-32 [15579627] Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40 [15803139] Am J Respir Cell Mol Biol. 2005 Nov;33(5):455-62 [16055670] Curr Mol Med. 2007 Feb;7(1):3-14 [17311529] J Pharmacol Exp Ther. 2007 Aug;322(2):529-40 [17496163] Nature. 2007 Aug 16;448(7155):807-10 [17676035] Annu Rev Pathol. 2006;1:331-48 [18039118] J Invest Dermatol. 2008 Jun;128(6):1517-24 [18049449] J Cell Biol. 2000 Apr 3;149(1):17-22 [10747083] Cancer Res. 2000 Aug 1;60(15):4005-9 [10945598] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13031-6 [11698679] Methods. 2001 Dec;25(4):402-8 [11846609] Transgenic Res. 2002 Feb;11(1):21-9 [11874100] Respir Res. 2002;3:20 [11980589] Histopathology. 2002 May;40(5):403-39 [12010363] Pathol Int. 2002 Apr;52(4):286-93 [12031084] Bioessays. 2002 Sep;24(9):789-800 [12210515] Am J Pathol. 2004 Feb;164(2):577-88 [14742263] Cancer Res. 2004 Mar 1;64(5):1647-54 [14996723] J Invest Dermatol. 2004 May;122(5):1207-13 [15140224] J Mol Biol. 1975 Nov 5;98(3):503-17 [1195397] Lab Invest. 1978 Jun;38(6):648-53 [661220] J Anat. 1981 Jan;132(Pt 1):71-84 [7275793] Cell. 1982 Nov;31(1):11-24 [6186379] Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(2):221-40 [6143448] Proc Natl Acad Sci U S A. 1984 Apr;81(7):1991-5 [6326095] Anal Biochem. 1984 Feb;137(1):266-7 [6329026] J Immunol. 1985 Oct;135(4):2589-92 [4031496] EMBO J. 1986 Jul;5(7):1567-75 [3017704] Cell. 1987 Feb 13;48(3):453-63 [2433047] Lab Invest. 1987 Aug;57(2):219-29 [3613528] J Invest Dermatol. 1989 Feb;92(2):203-9 [2465352] Mol Cell Biol. 1989 Sep;9(9):3685-97 [2476664] Am J Clin Pathol. 1992 Feb;97(2):233-43 [1372146] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn190 ER - TY - JOUR T1 - Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. AN - 69852194; 19047179 AB - Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here, we describe the involvement of BRCA2 in O6-alkylguanine DNA alkyltransferase (AGT)-mediated repair of O6-methylguanine adducts. We show that BRCA2 physically associates and undergoes repair-mediated degradation with AGT. In contrast, BRCA2 with a 29-amino-acid deletion in an evolutionarily conserved domain does not bind to alkylated AGT; the two proteins are not degraded; and mouse embryonic fibroblasts are specifically sensitive to alkylating agents that result in O6-methylguanine adducts. We show that O6-benzylguanine (O6BG), a nontoxic inhibitor of AGT, can also induce BRCA2 degradation. BRCA2 is a viable target for cancer therapy because BRCA2-deficient cells are hypersensitive to chemotherapeutic DNA-damaging agents. We show a marked effect of O6BG pretreatment on cell sensitivity to cisplatin. We also show the efficacy of this approach on a wide range of human tumor cell lines, which suggests that chemosensitization of tumors by targeted degradation of BRCA2 may be an important consideration when devising cancer therapeutics. JF - Cancer research AU - Philip, Subha AU - Swaminathan, Srividya AU - Kuznetsov, Sergey G AU - Kanugula, Sreenivas AU - Biswas, Kajal AU - Chang, Suhwan AU - Loktionova, Natalia A AU - Haines, Diana C AU - Kaldis, Philipp AU - Pegg, Anthony E AU - Sharan, Shyam K AD - Mouse Cancer Genetics Program, Center for Cancer Research, and Pathology Histotechnology Laboratory, Science Applications International Corporation-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 9973 EP - 9981 VL - 68 IS - 23 KW - Alkylating Agents KW - 0 KW - BRCA2 Protein KW - BRCA2 protein, mouse KW - O(6)-benzylguanine KW - 01KC87F8FE KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - Guanine KW - 5Z93L87A1R KW - O-(6)-methylguanine KW - 9B710FV2AE KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Index Medicus KW - Animals KW - Humans KW - Molecular Sequence Data KW - Mice KW - Guanine -- analogs & derivatives KW - Amino Acid Sequence KW - Mice, Transgenic KW - Guanine -- pharmacology KW - Guanine -- metabolism KW - Mice, Knockout KW - Gene Deletion KW - DNA Repair -- physiology KW - O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors KW - O(6)-Methylguanine-DNA Methyltransferase -- metabolism KW - BRCA2 Protein -- metabolism KW - BRCA2 Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69852194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Degradation+of+BRCA2+in+alkyltransferase-mediated+DNA+repair+and+its+clinical+implications.&rft.au=Philip%2C+Subha%3BSwaminathan%2C+Srividya%3BKuznetsov%2C+Sergey+G%3BKanugula%2C+Sreenivas%3BBiswas%2C+Kajal%3BChang%2C+Suhwan%3BLoktionova%2C+Natalia+A%3BHaines%2C+Diana+C%3BKaldis%2C+Philipp%3BPegg%2C+Anthony+E%3BSharan%2C+Shyam+K&rft.aulast=Philip&rft.aufirst=Subha&rft.date=2008-12-01&rft.volume=68&rft.issue=23&rft.spage=9973&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1179 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Mol Mutagen. 2001;38(2-3):235-43 [11746760] Clin Cancer Res. 2007 May 1;13(9):2728-37 [17473206] Cancer Res. 2002 Feb 15;62(4):990-4 [11861370] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13920-5 [10570174] Mutat Res. 2000 Apr;462(2-3):83-100 [10767620] Genesis. 2001 Jan;29(1):14-21 [11135458] Oncogene. 2001 Jul 5;20(30):3937-48 [11494122] Bioessays. 2002 Mar;24(3):255-66 [11891762] J Clin Oncol. 2002 May 1;20(9):2388-99 [11981013] Science. 2002 Jul 26;297(5581):606-9 [12065746] Genes Chromosomes Cancer. 2003 Apr;36(4):317-31 [12619154] Mol Cancer Ther. 2003 Jul;2(7):633-40 [12883036] Nat Rev Cancer. 2004 Apr;4(4):296-307 [15057289] J Biol Chem. 1982 Nov 25;257(22):13776-80 [6754717] Proc Natl Acad Sci U S A. 1990 Jul;87(14):5368-72 [2164681] Carcinogenesis. 1991 Sep;12(9):1679-83 [1893528] J Med Chem. 1992 Nov 13;35(23):4486-91 [1447749] Prog Nucleic Acid Res Mol Biol. 1995;51:167-223 [7659775] Biochemistry. 1996 Jan 30;35(4):1328-34 [8573590] Carcinogenesis. 1996 Jun;17(6):1215-20 [8681434] Nature. 1997 Apr 24;386(6627):804-10 [9126738] Genes Dev. 1997 May 15;11(10):1226-41 [9171368] Genes Dev. 1997 May 15;11(10):1242-52 [9171369] Cancer Res. 1997 Jun 15;57(12):2415-8 [9192819] Nat Genet. 1997 Dec;17(4):423-30 [9398843] J Biol Chem. 1997 Dec 19;272(51):31941-4 [9405383] Cancer Res. 1998 Apr 1;58(7):1338-43 [9537225] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5287-92 [9560268] Mol Cell. 1998 Feb;1(3):347-57 [9660919] J Natl Cancer Inst. 1998 Jul 1;90(13):978-85 [9665145] Hum Genet. 1998 Aug;103(2):154-61 [9760198] Annu Rev Genet. 1998;32:95-121 [9928476] Mutagenesis. 1999 May;14(3):339-47 [10375003] J Pharmacol Exp Ther. 2005 Jan;312(1):206-13 [15304523] Clin Exp Metastasis. 2004;21(6):543-52 [15679052] Cancer Chemother Pharmacol. 2005 Apr;55(4):333-42 [15723259] Nature. 2005 Apr 14;434(7035):913-7 [15829966] Nature. 2005 Apr 14;434(7035):917-21 [15829967] Genes Chromosomes Cancer. 2005 Dec;44(4):429-37 [16127665] Cancer Res. 2005 Nov 15;65(22):10145-8 [16287996] Cancer Treat Rev. 2006 Jun;32(4):261-76 [16698182] Int J Biol Sci. 2006;2(4):179-85 [16810332] Curr Opin Pharmacol. 2006 Aug;6(4):355-63 [16777483] Oncogene. 2006 Sep 25;25(43):5885-97 [16998503] Cancer Treat Rev. 2007 Feb;33(1):9-23 [17084534] Cell. 2002 Jan 25;108(2):171-82 [11832208] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1179 ER - TY - JOUR T1 - Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. AN - 69848358; 18773491 AB - Nodal signaling is a critical regulator of multiple aspects of early vertebrate development including asymmetry along the left/right (LR) axis. To study Nodal function occurring specifically in the postgastrulation embryo, we have used Cre/loxP based conditional mutagenesis. A floxed allele of Nodal was generated and shown to have wild-type function. This allele was then used in conjunction with the T-Cre line, which expresses Cre recombinase broadly in the mesodermal and definitive endodermal lineages posterior to the cranial region. T-Cre activity leads to complete deletion of Nodal before its normal transient expression in the early somite stage lateral plate mesoderm, thereby causing severe LR developmental defects. No other abnormalities were found, suggesting that Nodal signaling has no additional essential functions in developmental patterning within the extensive mesodermal and endodermal domains marked by T-Cre activity. JF - Developmental dynamics : an official publication of the American Association of Anatomists AU - Kumar, Amit AU - Lualdi, Margaret AU - Lewandoski, Mark AU - Kuehn, Michael R AD - Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3591 EP - 3601 VL - 237 IS - 12 SN - 1058-8388, 1058-8388 KW - Nodal Protein KW - 0 KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Index Medicus KW - Body Patterning KW - Animals KW - Integrases -- genetics KW - Mice KW - Mice, Transgenic KW - Embryo, Mammalian -- metabolism KW - Gene Deletion KW - Phenotype KW - Alleles KW - Base Sequence KW - Genes, Reporter -- genetics KW - Integrases -- metabolism KW - Embryo, Mammalian -- embryology KW - Mutation -- genetics KW - Gene Expression Regulation, Developmental KW - Mesoderm -- embryology KW - Nodal Protein -- genetics KW - Endoderm -- embryology KW - Gastrointestinal Tract -- metabolism KW - Gastrointestinal Tract -- embryology KW - Endoderm -- metabolism KW - Mesoderm -- metabolism KW - Nodal Protein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69848358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+dynamics+%3A+an+official+publication+of+the+American+Association+of+Anatomists&rft.atitle=Broad+mesodermal+and+endodermal+deletion+of+Nodal+at+postgastrulation+stages+results+solely+in+left%2Fright+axial+defects.&rft.au=Kumar%2C+Amit%3BLualdi%2C+Margaret%3BLewandoski%2C+Mark%3BKuehn%2C+Michael+R&rft.aulast=Kumar&rft.aufirst=Amit&rft.date=2008-12-01&rft.volume=237&rft.issue=12&rft.spage=3591&rft.isbn=&rft.btitle=&rft.title=Developmental+dynamics+%3A+an+official+publication+of+the+American+Association+of+Anatomists&rft.issn=10588388&rft_id=info:doi/10.1002%2Fdvdy.21665 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genesis. 2000 Feb;26(2):118-20 [10686603] Genesis. 2007 Dec;45(12):729-36 [18064671] Development. 2001 May;128(10):1831-43 [11311163] Nat Rev Genet. 2001 Oct;2(10):743-55 [11584291] Genes Dev. 2002 Sep 15;16(18):2339-44 [12231623] Dev Biol. 2003 Apr 1;256(1):160-72 [12654299] BMC Dev Biol. 2001;1:4 [11299042] Dev Cell. 2004 Jan;6(1):7-28 [14723844] Semin Cell Dev Biol. 2004 Oct;15(5):543-54 [15271300] Semin Cell Dev Biol. 2004 Oct;15(5):555-61 [15271301] Dev Biol. 2004 Sep 1;273(1):149-59 [15302604] Mol Cell Biol. 2004 Nov;24(21):9383-9 [15485907] Dev Dyn. 1992 Jul;194(3):198-208 [1467556] Nature. 1993 Feb 11;361(6412):543-7 [8429908] Development. 1994 Jul;120(7):1919-28 [7924997] Nature. 1996 May 9;381(6578):158-61 [8610013] Genes Dev. 1997 Jul 15;11(14):1812-26 [9242489] Nat Genet. 1998 Feb;18(2):136-41 [9462741] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3667-72 [9520423] Nat Genet. 1999 Jan;21(1):70-1 [9916792] Mech Dev. 2005 Jan;122(1):3-25 [15582774] Development. 2005 Sep;132(17):3859-71 [16049111] Cell. 2006 Apr 7;125(1):33-45 [16615888] Dev Biol. 2006 May 15;293(2):370-81 [16564040] Cell. 2006 Oct 6;127(1):27-32 [17018270] Differentiation. 2007 Feb;75(2):133-46 [17316383] Development. 2007 Mar;134(6):1023-34 [17287255] Methods Mol Biol. 2000;137:125-37 [10948531] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/dvdy.21665 ER - TY - JOUR T1 - Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. AN - 69847827; 19047460 AB - Cellular responses to both physiological and pathological DNA double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (ATM) kinase. Upon DNA damage, an activation mechanism involving autophosphorylation has been reported to allow ATM to phosphorylate downstream targets important for cell cycle checkpoints and DNA repair. In humans, serine residues 367, 1893, and 1981 have been shown to be autophosphorylation sites that are individually required for ATM activation. To test the physiological importance of these sites, we generated a transgenic mouse model in which all three conserved ATM serine autophosphorylation sites (S367/1899/1987) have been replaced with alanine. In this study, we show that ATM-dependent responses at both cellular and organismal levels are functional in mice that express a triple serine mutant form of ATM as their sole ATM species. These results lend further support to the notion that ATM autophosphorylation correlates with the DNA damage-induced activation of the kinase but is not required for ATM function in vivo. JF - The Journal of cell biology AU - Daniel, Jeremy A AU - Pellegrini, Manuela AU - Lee, Ji-Hoon AU - Paull, Tanya T AU - Feigenbaum, Lionel AU - Nussenzweig, André AD - Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 777 EP - 783 VL - 183 IS - 5 KW - Cell Cycle Proteins KW - 0 KW - DNA-Binding Proteins KW - Tumor Suppressor Proteins KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Atm protein, mouse KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Animals KW - Enzyme Activation KW - Genes, cdc KW - Mice KW - Amino Acid Sequence KW - Dose-Response Relationship, Radiation KW - Mice, Transgenic KW - Intestine, Small -- radiation effects KW - Phosphorylation KW - Genomic Instability KW - Cells, Cultured KW - Recombination, Genetic KW - Molecular Sequence Data KW - Lymphocytes -- enzymology KW - Testis -- enzymology KW - Mutation KW - Male KW - Intestine, Small -- enzymology KW - Cell Nucleus -- enzymology KW - Protein-Serine-Threonine Kinases -- metabolism KW - Cell Cycle Proteins -- genetics KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - DNA-Binding Proteins -- genetics KW - Protein-Serine-Threonine Kinases -- genetics KW - DNA Breaks, Double-Stranded KW - Cell Nucleus -- radiation effects KW - DNA-Binding Proteins -- metabolism KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69847827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Multiple+autophosphorylation+sites+are+dispensable+for+murine+ATM+activation+in+vivo.&rft.au=Daniel%2C+Jeremy+A%3BPellegrini%2C+Manuela%3BLee%2C+Ji-Hoon%3BPaull%2C+Tanya+T%3BFeigenbaum%2C+Lionel%3BNussenzweig%2C+Andr%C3%A9&rft.aulast=Daniel&rft.aufirst=Jeremy&rft.date=2008-12-01&rft.volume=183&rft.issue=5&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=1540-8140&rft_id=info:doi/10.1083%2Fjcb.200805154 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2002 Jun 20;21(27):4191-9 [12082606] Genes Dev. 2002 Mar 1;16(5):571-82 [11877377] Nature. 2003 Jan 30;421(6922):499-506 [12556884] Nat Rev Cancer. 2003 Mar;3(3):155-68 [12612651] Nucleic Acids Res. 2003 Aug 1;31(15):e80 [12888532] EMBO J. 2003 Oct 15;22(20):5612-21 [14532133] EMBO J. 2003 Dec 15;22(24):6610-20 [14657032] Science. 2004 Apr 2;304(5667):93-6 [15064416] Cell. 1996 Jul 12;86(1):159-71 [8689683] Genes Dev. 1996 Oct 1;10(19):2411-22 [8843194] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13084-9 [8917548] Science. 1998 Sep 11;281(5383):1674-7 [9733514] Science. 1998 Sep 11;281(5383):1677-9 [9733515] Science. 1998 Dec 4;282(5395):1893-7 [9836640] Adv Immunol. 1999;72:179-89 [10361575] Oncogene. 1999 Jul 15;18(28):4047-54 [10435585] J Exp Med. 2004 Nov 1;200(9):1111-21 [15504820] J Exp Med. 2004 Nov 1;200(9):1103-10 [15520243] Science. 2005 Apr 22;308(5721):551-4 [15790808] Mol Cell Biol. 2005 Jul;25(13):5363-79 [15964794] Nat Cell Biol. 2005 Jul;7(7):675-85 [15965469] J Clin Pathol. 2005 Oct;58(10):1009-15 [16189143] Immunol Rev. 2006 Feb;209:142-58 [16448540] Mol Cell Biol. 2006 Mar;26(5):1691-9 [16478990] Nat Struct Mol Biol. 2006 May;13(5):451-7 [16622404] Nature. 2006 Jul 27;442(7101):466-70 [16799570] Nat Cell Biol. 2006 Aug;8(8):870-6 [16862143] EMBO J. 2006 Aug 9;25(15):3504-14 [16858402] Nature. 2006 Sep 14;443(7108):222-5 [16906133] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6323-8 [17405860] Science. 2007 May 25;316(5828):1160-6 [17525332] Nat Cell Biol. 2007 Jun;9(6):683-90 [17486112] J Exp Med. 2007 Jun 11;204(6):1371-81 [17502661] Cell. 2007 Jul 13;130(1):63-75 [17599403] Annu Rev Genomics Hum Genet. 2007;8:37-55 [17887919] Nat Cell Biol. 2007 Nov;9(11):1311-8 [17952060] Mol Cell Biol. 2007 Dec;27(24):8502-9 [17923702] Oncogene. 2007 Dec 10;26(56):7741-8 [18066086] Oncogene. 2007 Dec 10;26(56):7759-64 [18066088] Annu Rev Immunol. 2008;26:261-92 [18370922] J Biol Chem. 2001 Oct 12;276(41):38224-30 [11454856] Genes Dev. 2002 Mar 1;16(5):560-70 [11877376] Nat Cell Biol. 2002 Dec;4(12):993-7 [12447390] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1083/jcb.200805154 ER - TY - JOUR T1 - SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cells. AN - 69846388; 19047146 AB - The malignant transformation in several types of cancer, including lung cancer, results in a loss of growth inhibition by transforming growth factor-beta (TGF-beta). Here, we show that SMAD6 expression is associated with a reduced survival in lung cancer patients. Short hairpin RNA (shRNA)-mediated knockdown of SMAD6 in lung cancer cell lines resulted in reduced cell viability and increased apoptosis as well as inhibition of cell cycle progression. However, these results were not seen in Beas2B, a normal bronchial epithelial cell line. To better understand the mechanism underlying the association of SMAD6 with poor patient survival, we used a lentivirus construct carrying shRNA for SMAD6 to knock down expression of the targeted gene. Through gene expression analysis, we observed that knockdown of SMAD6 led to the activation of TGF-beta signaling through up-regulation of plasminogen activator inhibitor-1 and phosphorylation of SMAD2/3. Furthermore, SMAD6 knockdown activated the c-Jun NH2-terminal kinase pathway and reduced phosphorylation of Rb-1, resulting in increased G0-G1 cell arrest and apoptosis in the lung cancer cell line H1299. These results jointly suggest that SMAD6 plays a critical role in supporting lung cancer cell growth and survival. Targeted inactivation of SMAD6 may provide a novel therapeutic strategy for lung cancers expressing this gene. JF - Cancer research AU - Jeon, Hyo-Sung AU - Dracheva, Tatiana AU - Yang, Sei-Hoon AU - Meerzaman, Daoud AU - Fukuoka, Junya AU - Shakoori, Abbas AU - Shilo, Konstantin AU - Travis, William D AU - Jen, Jin AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 9686 EP - 9692 VL - 68 IS - 23 KW - RNA, Small Interfering KW - 0 KW - SMAD6 protein, human KW - Smad6 Protein KW - Transforming Growth Factor beta KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Phosphorylation KW - Down-Regulation KW - Cell Growth Processes -- physiology KW - Humans KW - Cell Cycle -- physiology KW - Apoptosis -- physiology KW - Transduction, Genetic KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - Immunohistochemistry KW - Signal Transduction KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Smad6 Protein -- genetics KW - Smad6 Protein -- biosynthesis KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- genetics KW - Transforming Growth Factor beta -- metabolism KW - Smad6 Protein -- deficiency KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69846388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=SMAD6+contributes+to+patient+survival+in+non-small+cell+lung+cancer+and+its+knockdown+reestablishes+TGF-beta+homeostasis+in+lung+cancer+cells.&rft.au=Jeon%2C+Hyo-Sung%3BDracheva%2C+Tatiana%3BYang%2C+Sei-Hoon%3BMeerzaman%2C+Daoud%3BFukuoka%2C+Junya%3BShakoori%2C+Abbas%3BShilo%2C+Konstantin%3BTravis%2C+William+D%3BJen%2C+Jin&rft.aulast=Jeon&rft.aufirst=Hyo-Sung&rft.date=2008-12-01&rft.volume=68&rft.issue=23&rft.spage=9686&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1083 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Genomics. 2007;8:98 [17425807] Cancer Res. 2007 Mar 1;67(5):2317-24 [17332363] N Engl J Med. 2000 May 4;342(18):1350-8 [10793168] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4820-5 [10781087] Nat Cell Biol. 2000 Apr;2(4):E65-7 [10783254] J Natl Cancer Inst. 2000 Sep 6;92(17):1388-402 [10974075] Cell. 2000 Oct 13;103(2):239-52 [11057897] J Cell Physiol. 2001 Jun;187(3):265-76 [11319750] Trends Cell Biol. 2001 Nov;11(11):S44-51 [11684442] J Cell Biol. 2001 Dec 10;155(6):1017-27 [11739411] Nature. 2002 Aug 8;418(6898):641-6 [12167862] Cancer Res. 2003 Nov 15;63(22):7760-8 [14633701] Mol Cell Biol. 2003 Dec;23(24):9081-93 [14645520] Clin Cancer Res. 2004 Jul 1;10(13):4314-24 [15240517] Cancer Biol Ther. 2004 Jul;3(7):667-75 [15197354] Proc Natl Acad Sci U S A. 1986 Apr;83(8):2438-42 [2871553] EMBO J. 1987 May;6(5):1281-6 [3111844] Science. 1988 Apr 8;240(4849):196-9 [2895499] Cancer Res. 1988 Jul 15;48(14):3898-904 [3164252] Cancer Res. 1996 Nov 1;56(21):4831-5 [8895728] J Biol Chem. 1997 Jan 17;272(3):1429-32 [8999807] Lung Cancer. 1996 Dec;16(1):47-59 [9017584] Cell. 1997 Jun 27;89(7):1165-73 [9215638] Nature. 1997 Oct 9;389(6651):622-6 [9335505] Nature. 1997 Oct 9;389(6651):631-5 [9335507] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10669-74 [9380693] Nature. 1997 Dec 4;390(6659):465-71 [9393997] Genes Dev. 1998 Jan 15;12(2):186-97 [9436979] EMBO J. 1998 Jun 1;17(11):3091-100 [9606191] Annu Rev Biochem. 1998;67:753-91 [9759503] Oncogene. 1998 Oct 1;17(13):1743-7 [9796704] Oncogene. 1999 May 20;18(20):3098-103 [10340381] Oncogene. 1999 Sep 23;18(39):5363-72 [10498890] Anticancer Res. 2004 Nov-Dec;24(6):3703-9 [15736400] J Natl Cancer Inst. 2005 Dec 7;97(23):1734-46 [16333029] J Biol Chem. 2006 Jul 21;281(29):20357-67 [16687405] Nat Immunol. 2006 Oct;7(10):1057-65 [16951688] Oncogene. 1999 Dec 2;18(51):7280-6 [10602482] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1083 ER - TY - JOUR T1 - Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma: a population-based analysis. AN - 69840096; 18823043 AB - Radiotherapy for Hodgkin lymphoma (HL) increases the risk of salivary gland carcinomas (SGC). To the authors' knowledge, however, the magnitude of the risk has not been assessed to date. The risks of SGC among 20,928 1-year survivors of HL who were diagnosed between 1973 and 2003 were evaluated in 11 population-based cancer registry areas of the Surveillance, Epidemiology, and End Results (SEER) program. Observed-to-expected ratios (O/E) were assessed by radiation treatment, sex, age at the time of HL diagnosis, calendar year of diagnosis, attained age, time since HL diagnosis, histologic type of SGC, and site of occurrence in the major salivary glands. Among 11,047 HL patients who received radiotherapy as part of their initial treatment for HL, 21 developed subsequent invasive SGC (O/E = 16.9; 95% confidence interval [95% CI], 10.4-25.8). The risk of radiation-related SGC was highest for younger HL patients (age <20 years) (O/E = 45.5; 95% CI, 12.4-116.5) and among 10-year survivors (O/E = 23.9; 95% CI, 13.1-40.1), with risks remaining elevated for at least 2 decades after irradiation. Significant differences in risk by histologic type were observed, with a particularly high risk of developing mucoepidermoid carcinomas (O = 14; O/E = 44.2 [95% CI, 24.2-74.2]) and adenocarcinomas (O = 4; O/E = 30.6 [95% CI, 8.3-78.2]) noted. HL patients treated with radiotherapy experienced a significantly increased risk of SGC, particularly when exposed at young ages or for at least 2 decades after exposure. Although the results of the current study reflect the late effects of former HL treatment approaches, they point to the importance of long-term follow-up and a heightened awareness of SGC risk in this population. (c) 2008 American Cancer Society JF - Cancer AU - Boukheris, Houda AU - Ron, Elaine AU - Dores, Graça M AU - Stovall, Marilyn AU - Smith, Susan A AU - Curtis, Rochelle E AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. boukherh@mail.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 3153 EP - 3159 VL - 113 IS - 11 SN - 0008-543X, 0008-543X KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Age Factors KW - Humans KW - SEER Program KW - Adult KW - Male KW - Female KW - Risk Assessment KW - Hodgkin Disease -- radiotherapy KW - Hodgkin Disease -- pathology KW - Salivary Gland Neoplasms -- etiology KW - Neoplasms, Second Primary -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69840096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Risk+of+radiation-related+salivary+gland+carcinomas+among+survivors+of+Hodgkin+lymphoma%3A+a+population-based+analysis.&rft.au=Boukheris%2C+Houda%3BRon%2C+Elaine%3BDores%2C+Gra%C3%A7a+M%3BStovall%2C+Marilyn%3BSmith%2C+Susan+A%3BCurtis%2C+Rochelle+E&rft.aulast=Boukheris&rft.aufirst=Houda&rft.date=2008-12-01&rft.volume=113&rft.issue=11&rft.spage=3153&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.23918 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-13 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Surg. 1978 Jun;135(6):820-4 [149506] Am J Surg. 1968 Oct;116(4):518-23 [4300240] Int J Epidemiol. 1984 Mar;13(1):112-5 [6698695] Am J Surg. 1984 Mar;147(3):345-8 [6703206] Cancer. 1984 Nov 1;54(9):1854-9 [6478421] Int J Cancer. 1987 May 15;39(5):571-85 [3570550] J Am Dent Assoc. 1990 Feb;120(2):151-8 [2405031] Ann Oncol. 1992 Sep;3 Suppl 4:117-28 [1450072] Blood. 1994 Jan 15;83(2):318-29 [8286731] Radiat Res. 1996 Jul;146(1):28-36 [8677295] N Engl J Med. 1997 Mar 27;336(13):897-904 [9070469] Cancer. 1997 Apr 15;79(8):1465-75 [9118025] J Clin Oncol. 1998 Feb;16(2):536-44 [9469338] Radiat Res. 1998 Jun;149(6):625-30 [9611101] Laryngoscope. 1998 Jul;108(7):1095-7 [9665263] Radiat Res. 2006 Jul;166(1 Pt 2):141-57 [16808603] Radiat Res. 2007 Jul;168(1):1-64 [17722996] N Engl J Med. 2007 Nov 8;357(19):1916-27 [17989384] N Engl J Med. 2007 Nov 8;357(19):1968-71 [17989391] J Clin Oncol. 2000 Jun;18(12):2435-43 [10856104] Br J Haematol. 2000 Sep;110(3):504-11 [10997959] J Clin Oncol. 2001 Nov 15;19(22):4238-44 [11709567] J Clin Oncol. 2002 Aug 15;20(16):3484-94 [12177110] Cancer. 2003 Aug 1;98(3):562-70 [12879474] Cancer J. 2003 Nov-Dec;9(6):467-71 [14740975] J Clin Oncol. 2004 Jul 15;22(14):2835-41 [15199092] Cancer. 1983 Jun 15;51(12):2159-63 [6850504] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.23918 ER - TY - JOUR T1 - Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures. AN - 69839991; 18845770 AB - Meconium analysis is a diagnostically sensitive and objective alternative to maternal self-report for detecting prenatal tobacco exposure. Nicotine and metabolite disposition in meconium is poorly characterized, and correlation of analytes' concentrations with neonatal outcomes is unexplored. Our objectives were to quantify nicotine, cotinine, trans-3'-hydroxycotinine (OH-cotinine), nornicotine, norcotinine, and glucuronide concentrations in meconium, identify the best biomarkers of in utero tobacco exposure, compare meconium concentrations of tobacco-exposed and nonexposed neonates, and investigate concentration-outcome relationships. We quantified concentrations of nicotine and 4 metabolites with and without hydrolysis simultaneously in meconium from tobacco-exposed and nonexposed neonates by liquid chromatography-tandem mass spectrometry. We compared meconium concentrations to birth weight, length, head circumference, gestational age, and 1- and 5-min Apgar scores. Nicotine, cotinine, and OH-cotinine were the most prevalent and abundant meconium tobacco biomarkers and were found in higher concentrations in tobacco-exposed neonates. Whereas cotinine and OH-cotinine are glucuronide bound, performing the lengthy and costly enzymatic hydrolysis identified only 1 additional positive specimen. Unconjugated nicotine, cotinine, or OH-cotinine meconium concentration >10 ng/g most accurately discriminated active from passive and nonexposed neonates. There was no significant correlation between quantitative nicotine and metabolite meconium results and neonatal outcomes, although presence of a nicotine biomarker predicted decreased head circumference. Unconjugated nicotine, cotinine, and OH-cotinine should be analyzed in meconium to detect in utero tobacco exposure, as approximately 25% of positive specimens did not contain cotinine. Immunoassay testing monitoring cotinine only would underestimate the prevalence of prenatal tobacco exposure. JF - Clinical chemistry AU - Gray, Teresa R AU - Magri, Raquel AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2018 EP - 2027 VL - 54 IS - 12 KW - Biomarkers KW - 0 KW - Glucuronates KW - Tobacco Smoke Pollution KW - nicotine N-glucuronide KW - 152306-59-7 KW - norcotinine KW - 17114-40-8 KW - hydroxycotinine KW - 27323-64-4 KW - Nicotine KW - 6M3C89ZY6R KW - nornicotine KW - 83H6L5QD8Z KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Cotinine -- analysis KW - Glucuronates -- analysis KW - Humans KW - Gestational Age KW - Infant, Newborn KW - Tandem Mass Spectrometry KW - Hydrolysis KW - Pregnancy KW - Apgar Score KW - Biomarkers -- analysis KW - Chromatography, Liquid KW - Cotinine -- analogs & derivatives KW - Female KW - Body Size KW - Maternal Exposure -- adverse effects KW - Maternal-Fetal Exchange KW - Nicotine -- metabolism KW - Meconium -- chemistry KW - Nicotine -- analysis KW - Nicotine -- adverse effects KW - Tobacco Smoke Pollution -- adverse effects KW - Nicotine -- analogs & derivatives KW - Smoking -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Meconium+nicotine+and+metabolites+by+liquid+chromatography-tandem+mass+spectrometry%3A+differentiation+of+passive+and+nonexposure+and+correlation+with+neonatal+outcome+measures.&rft.au=Gray%2C+Teresa+R%3BMagri%2C+Raquel%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Gray&rft.aufirst=Teresa&rft.date=2008-12-01&rft.volume=54&rft.issue=12&rft.spage=2018&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=1530-8561&rft_id=info:doi/10.1373%2Fclinchem.2008.109173 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-09 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Matern Child Health J. 1998 Jun;2(2):77-83 [10728263] Neonatology. 2008;94(2):75-8 [18212492] Chem Res Toxicol. 2003 Dec;16(12):1502-6 [14680362] Sao Paulo Med J. 2004 May 6;122(3):94-8 [15448806] Br J Obstet Gynaecol. 1987 Jul;94(7):678-81 [3620415] Arch Toxicol. 1988;62(5):395-7 [3242451] JAMA. 1993 Mar 24-31;269(12):1519-24 [8445814] J Pediatr. 1994 Mar;124(3):471-6 [8120724] Br J Obstet Gynaecol. 1996 Aug;103(8):806-13 [8760712] Addict Behav. 1996 Sep-Oct;21(5):675-9 [8876767] Clin Chem. 1997 Jan;43(1):180-1 [8990243] J Chromatogr B Biomed Sci Appl. 1998 Apr 10;707(1-2):317-21 [9613966] Am J Epidemiol. 1998 Aug 1;148(3):259-62 [9690362] Pharmacology. 1998 Aug;57(2):104-16 [9691230] Life Sci. 1998;63(26):2333-42 [9877223] Hum Exp Toxicol. 1999 Apr;18(4):283-90 [10333316] Forensic Sci Int. 1999 Jun 28;102(2-3):167-71 [10464932] Drug Metab Dispos. 2005 Jan;33(1):23-30 [15470160] East Mediterr Health J. 2004 Jan-Mar;10(1-2):96-105 [16201714] Paediatr Perinat Epidemiol. 2006 Mar;20(2):90-9 [16466427] Acta Obstet Gynecol Scand. 2006;85(11):1331-7 [17091413] BMC Public Health. 2007;7:81 [17506887] Hum Exp Toxicol. 2007 Jun;26(6):535-44 [17698949] Nicotine Tob Res. 2007 Oct;9(10):1005-13 [17852766] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):107-14 [18243821] Paediatr Perinat Epidemiol. 2008 Mar;22(2):162-71 [18298691] Pediatrics. 2008 Apr;121(4):e810-6 [18381510] Acta Obstet Gynecol Scand. 2002 Mar;81(3):240-4 [11966481] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1373/clinchem.2008.109173 ER - TY - JOUR T1 - Analysis of ordered categorical data: two score-independent approaches. AN - 69835239; 18266890 AB - A trend test is often employed to analyze ordered categorical data, in which a set of increasing scores is assigned a priori. There is a drawback in this approach, because how to choose a set of scores is not clear. There have been debates on which scores should be used (e.g., Graubard and Korn, 1987, Biometrics 43, 471-476; Ivanova and Berger, 2001, Biometrics 57, 567-570; Senn, 2007, Biometrics 63, 296-298). Conflicting conclusions are often obtained with different sets of scores. Two approaches, which have been applied to genetic case-control studies, are appealing for ordered categorical data, because they take into account the natural order in the data, are score independent, and not contingent on asymptotic theory. These two approaches are applied to a prospective study for detecting association between maternal drinking and congenital malformations. JF - Biometrics AU - Zheng, Gang AD - Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892-7913, USA. zhengg@nhlbi.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1276 EP - 1279 VL - 64 IS - 4 KW - Index Medicus KW - Maternal-Fetal Exchange KW - Mothers KW - Humans KW - Alcohol Drinking -- adverse effects KW - Statistics as Topic KW - Abnormalities, Multiple -- chemically induced KW - Female KW - Pregnancy KW - Biometry -- methods KW - Case-Control Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69835239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Analysis+of+ordered+categorical+data%3A+two+score-independent+approaches.&rft.au=Zheng%2C+Gang&rft.aulast=Zheng&rft.aufirst=Gang&rft.date=2008-12-01&rft.volume=64&rft.issue=4&rft.spage=1276&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=1541-0420&rft_id=info:doi/10.1111%2Fj.1541-0420.2008.00992.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1541-0420.2008.00992.x ER - TY - JOUR T1 - Treatment of high-risk chronic GVHD. AN - 69834100; 19041069 JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation AU - Pavletic, Steven AU - Vogelsand, Georgia B AD - National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1436 EP - 1437 VL - 14 IS - 12 KW - Immunosuppressive Agents KW - 0 KW - Steroids KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Tacrolimus -- adverse effects KW - Steroids -- adverse effects KW - Acute Disease KW - Transplantation Conditioning KW - Humans KW - Steroids -- administration & dosage KW - Transplantation, Homologous KW - Tacrolimus -- administration & dosage KW - Risk KW - Leukemia, Myeloid, Acute -- therapy KW - Peripheral Blood Stem Cell Transplantation KW - Drug Eruptions KW - Adult KW - Chronic Disease KW - Female KW - Male KW - Immunosuppressive Agents -- administration & dosage KW - Immunosuppressive Agents -- adverse effects KW - Graft vs Host Disease -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69834100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fm