TY - JOUR T1 - Ciguatera Fish Poisoning: Treatment, Prevention and Management AN - 893283486; 15670006 AB - Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world, and it causes substantial physical and functional impact. It produces a myriad of gastrointestinal, neurologic and/or cardiovascular symptoms which last days to weeks, or even months. Although there are reports of symptom amelioration with some interventions (e.g. IV mannitol), the appropriate treatment for CFP remains unclear to many physicians. We review the literature on the treatments for CFP, including randomized controlled studies and anecdotal reports. The article is intended to clarify treatment options, and provide information about management and prevention of CFP, for emergency room physicians, poison control information providers, other health care providers, and patients. JF - Marine Drugs AU - Friedman, MA AU - Fleming, LE AU - Fernandez, M AU - Bienfang, P AU - Schrank, K AU - Dickey, R AU - Bottein, M-Y AU - Backer, L AU - Ayyar, R AU - Weisman, R AU - Watkins, S AU - Granade, R AU - Reich, A AD - University of Miami Rosenstiel School of Marine and Atmospheric Science, NSF/NIEHS Oceans & Human Health Center, 4600 Rickenbacker Causeway, East Grosvenor Building, #E211, Key Biscayne, FL 33149, USA, melissafried@yahoo.com Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 456 EP - 479 VL - 6 IS - 3 KW - Toxicology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA Marine Biotechnology Abstracts KW - Marine KW - Symptoms KW - Literature reviews KW - Fishery management KW - Mannitol KW - Aquatic drugs KW - Fish poisoning KW - Poisoning KW - Emergencies KW - Ciguatera KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q4 27790:Fish KW - X 24320:Food Additives & Contaminants KW - Q1 08485:Species interactions: pests and control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893283486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Drugs&rft.atitle=Ciguatera+Fish+Poisoning%3A+Treatment%2C+Prevention+and+Management&rft.au=Friedman%2C+MA%3BFleming%2C+LE%3BFernandez%2C+M%3BBienfang%2C+P%3BSchrank%2C+K%3BDickey%2C+R%3BBottein%2C+M-Y%3BBacker%2C+L%3BAyyar%2C+R%3BWeisman%2C+R%3BWatkins%2C+S%3BGranade%2C+R%3BReich%2C+A&rft.aulast=Friedman&rft.aufirst=MA&rft.date=2008-09-01&rft.volume=6&rft.issue=3&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Marine+Drugs&rft.issn=&rft_id=info:doi/10.3390%2Fmd20080022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Symptoms; Fishery management; Literature reviews; Aquatic drugs; Fish poisoning; Emergencies; Ciguatera; Mannitol; Poisoning; Marine DO - http://dx.doi.org/10.3390/md20080022 ER - TY - JOUR T1 - Responsive parenting is associated with improved type 1 diabetes-related quality of life AN - 839579509; 201100415 AB - Background Improved quality of life is an important treatment goal for children and adolescents with type 1 diabetes. While previous research supports a relationship between family environment and quality of life, little research has addressed the relationship of parenting style constructs to quality of life in children with chronic disease. The present investigation assesses the relationship of parent responsiveness and demandingness with diabetes-related quality of life among children and adolescents with type 1 diabetes. Methods Baseline and 12-month follow-up self-report assessments were collected on a sample of 81 children with type 1 diabetes participating in an efficacy trial of a behavioural intervention to enhance adherence. The sample had a mean age of 13.3 years (SD=1.7) and duration of diabetes of 7.7 years (SD=3.7). Multiple regression analyses were conducted to determine the relationship of parent responsiveness and demandingness to diabetes-related quality of life at each time point. Results After adjusting for demographic and diabetes characteristics, as well as diabetes-specific parent-child behaviours, parent responsiveness was significantly associated with baseline diabetes-related quality of life (b=0.23; P=0.04). This relationship was sustained at 12-month follow-up (b=0.22; P=0.04) after adjusting for baseline quality of life and treatment group assignment, suggesting that parent responsiveness is associated with improved quality of life. Conclusions Findings indicate the importance of a supportive and emotionally warm parenting style in promoting improved quality of life for children with type 1 diabetes. Appropriate parenting skills should be an element of diabetes family management health care. Adapted from the source document. JF - Child: Care, Health and Development AU - Botello-Harbaum, M AU - Nansel, T AU - Haynie, D L AU - Iannotti, R J AU - Simons-Morton, B AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, Division of Epidemiology and Statistics, Prevention Research Branch, Bethesda, MD, USA Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 675 EP - 681 PB - Blackwell Publishing, Oxford UK VL - 34 IS - 5 SN - 0305-1862, 0305-1862 KW - parenting style quality of life responsiveness type 1 diabetes KW - Parenting style KW - Responsiveness KW - Parents KW - Children KW - Type 1 diabetes mellitus KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839579509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child%3A+Care%2C+Health+and+Development&rft.atitle=Responsive+parenting+is+associated+with+improved+type+1+diabetes-related+quality+of+life&rft.au=Botello-Harbaum%2C+M%3BNansel%2C+T%3BHaynie%2C+D+L%3BIannotti%2C+R+J%3BSimons-Morton%2C+B&rft.aulast=Botello-Harbaum&rft.aufirst=M&rft.date=2008-09-01&rft.volume=34&rft.issue=5&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Child%3A+Care%2C+Health+and+Development&rft.issn=03051862&rft_id=info:doi/10.1111%2Fj.1365-2214.2008.00855.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - CCHDDH N1 - SubjectsTermNotLitGenreText - Quality of life; Responsiveness; Children; Type 1 diabetes mellitus; Parents; Parenting style DO - http://dx.doi.org/10.1111/j.1365-2214.2008.00855.x ER - TY - JOUR T1 - Genetic Variation in Sodium-Dependent Vitamin C Transporters SLC23A1 and SLC23A2 and Risk of Advanced Colorectal Adenoma AN - 754894388; 13517005 AB - Previous observational studies suggest that vitamin C may reduce risk of colorectal cancer. Vitamin C transport is facilitated by membrane bound sodium-dependent transporters, SVCT1 (encoded by SLC23A1) and SVCT2 (encoded by SLC23A2). To investigate if common genetic variants in these two genes are associated with risk of colorectal tumor development, we conducted a case-control study of 656 Caucasian advanced distal colorectal adenoma cases and 665 Caucasian sigmoidoscopy-negative controls nested within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association. For SLC23A2, overall, there was no association with haplotypes, but two SNPs located in intron 8 and exon 11 could be associated (odds ratio = 0.49, 95% confidence interval = 0.25-0.95 for haplotype G-C vs. haplotype C-C). The findings should be confirmed in follow-up studies, and further investigation is required to probe the functional basis of this finding. JF - Nutrition and Cancer AU - Erichsen, Hans Christian AU - Peters, Ulrike AU - Eck, Peter AU - Welch, Robert AU - Schoen, Robert E AU - Yeager, Meredith AU - Levine, Mark AU - Hayes, Richard B AU - Chanock, Stephen AD - Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 652 EP - 659 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 60 IS - 5 SN - 0163-5581, 0163-5581 KW - Risk Abstracts KW - risk reduction KW - vitamins KW - colorectal carcinoma KW - introns KW - ovarian carcinoma KW - tumors KW - genetic diversity KW - haplotypes KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754894388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+and+Cancer&rft.atitle=Genetic+Variation+in+Sodium-Dependent+Vitamin+C+Transporters+SLC23A1+and+SLC23A2+and+Risk+of+Advanced+Colorectal+Adenoma&rft.au=Erichsen%2C+Hans+Christian%3BPeters%2C+Ulrike%3BEck%2C+Peter%3BWelch%2C+Robert%3BSchoen%2C+Robert+E%3BYeager%2C+Meredith%3BLevine%2C+Mark%3BHayes%2C+Richard+B%3BChanock%2C+Stephen&rft.aulast=Erichsen&rft.aufirst=Hans&rft.date=2008-09-01&rft.volume=60&rft.issue=5&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=Nutrition+and+Cancer&rft.issn=01635581&rft_id=info:doi/10.1080%2F01635580802033110 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - risk reduction; vitamins; introns; colorectal carcinoma; ovarian carcinoma; genetic diversity; tumors; haplotypes; Cancer DO - http://dx.doi.org/10.1080/01635580802033110 ER - TY - JOUR T1 - NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A. AN - 733098700; 19407859 AB - The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for bisphenol A to cause adverse effects on reproduction and development in humans. The CERHR Expert Panel on Bisphenol A completed its evaluation in August 2007. CERHR selected bisphenol A for evaluation because of the: widespread human exposure; public concern for possible health effects from human exposures; high production volume; evidence of reproductive and developmental toxicity in laboratory animal studies Bisphenol A (CAS RN: 80-05-7) is a high production volume chemical used primarily in the production of polycarbonate plastics and epoxy resins. Polycarbonate plastics are used in some food and drink containers; the resins are used as lacquers to coat metal products such as food cans, bottle tops, and water supply pipes. To a lesser extent bisphenol A is used in the production of polyester resins, polysulfone resins, polyacrylate resins, and flame retardants. In addition, bisphenol A is used in the processing of polyvinyl chloride plastic and in the recycling of thermal paper. Some polymers used in dental sealants and tooth coatings contain bisphenol A. The primary source of exposure to bisphenol A for most people is assumed to occur through the diet. While air, dust, and water (including skin contact during bathing and swimming) are other possible sources of exposure, bisphenol A in food and beverages accounts for the majority of daily human exposure. The highest estimated daily intakes of bisphenol A in the general population occur in infants and children. The results of this bisphenol A evaluation are published in an NTP-CERHR Monograph that includes the (1) NTP Brief and (2) Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A. Additional information related to the evaluation process, including the peer review report for the NTP Brief and public comments received on the draft NTP Brief and the final expert panel report, are available on the CERHR website (http://cerhr.niehs.nih.gov/). See bisphenol A under "CERHR Chemicals" on the homepage or go directly to http://cerhr.niehs. nih.gov/chemicals/bisphenol/bisphenol.html). The NTP reached the following conclusions on the possible effects of exposure to bisphenol A on human development and reproduction. Note that the possible levels of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern, and serious concern. The NTP has some concern for effects on the brain, behavior, and prostate gland in fetuses, infants, and children at current human exposures to bisphenol A. The NTP has minimal concern for effects on the mammary gland and an earlier age for puberty for females in fetuses, infants, and children at current human exposures to bisphenol A. The NTP has negligible concern that exposure of pregnant women to bisphenol A will result in fetal or neonatal mortality, birth defects, or reduced birth weight and growth in their offspring. The NTP has negligible concern that exposure to bisphenol A will cause reproductive effects in non-occupationally exposed adults and minimal concern for workers exposed to higher levels in occupational settings. NTP will transmit the NTP-CERHR Monograph on Bisphenol A to federal and state agencies, interested parties, and the public and make it available in electronic PDF format on the CERHR web site (http://cerhr.niehs.nih.gov) and in printed text or CD from CERHR. JF - NTP CERHR MON AU - Shelby, Michael D AD - NIEHS, Research Triangle Park, NC 27709, USA. shelby@niehs.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - v, vii EP - ix, 1-64 passim IS - 22 SN - 1556-2271, 1556-2271 KW - Benzhydryl Compounds KW - 0 KW - Phenols KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Environmental Monitoring KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Environmental Exposure KW - Male KW - Female KW - Pregnancy KW - Fetus -- drug effects KW - Reproduction -- drug effects KW - Phenols -- pharmacokinetics KW - Phenols -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733098700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NTP+CERHR+MON&rft.atitle=NTP-CERHR+monograph+on+the+potential+human+reproductive+and+developmental+effects+of+bisphenol+A.&rft.au=Shelby%2C+Michael+D&rft.aulast=Shelby&rft.aufirst=Michael&rft.date=2008-09-01&rft.volume=&rft.issue=22&rft.spage=v&rft.isbn=&rft.btitle=&rft.title=NTP+CERHR+MON&rft.issn=15562271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-16 N1 - Date created - 2009-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Correlates of antioxidant nutrients and oxidative DNA damage differ by race in a cross-sectional study of healthy African American and white adults. AN - 69902945; 19083461 AB - Although antioxidant nutrients and oxidative DNA damage have been associated with carcinogenesis, few studies have investigated the factors that influence antioxidant intake and oxidative DNA damage in racially diverse populations. Demographic, behavioral, and diet-related psychosocial correlates of plasma antioxidant (carotenoids, vitamin C, and vitamin E) concentrations and oxidative DNA damage were examined using data from a cross-sectional study of 147 generally healthy, nonsmoking African American and white adults in North Carolina, aged 20 to 45 years. All participants completed self-administered demographic, diet, and health questionnaires and provided semifasting (> or = 6 hours) blood samples. Multivariate regression analyses were computed separately for each race to determine associations between the potential correlates with plasma antioxidant concentrations and oxidative DNA damage, separately. Our findings suggest appreciable differences by race. Only a few factors (age, supplement use, and several psychosocial factors) were associated with antioxidant concentrations in African Americans, whereas these and additional factors, including physical activity, waist circumference, and passive smoke exposure, were associated with antioxidant concentrations in whites. For oxidative DNA damage, passive smoke exposure was significantly associated with oxidative DNA damage in African Americans, and age and alcohol were significant in whites. In addition, the regression models generally explained more of the variance in plasma antioxidant concentrations and oxidative DNA damage in whites than in African Americans. Considering the salient correlates differed by race, this work has important implications for the design and implementation of future research studies investigating antioxidant nutrients and/or oxidative stress, especially those in racially diverse populations. JF - Nutrition research (New York, N.Y.) AU - Watters, Joanne L AU - Satia, Jessie A AU - Kupper, Lawrence L AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA. wattersj@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 565 EP - 576 VL - 28 IS - 9 KW - Antioxidants KW - 0 KW - Tobacco Smoke Pollution KW - Vitamin E KW - 1406-18-4 KW - Carotenoids KW - 36-88-4 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Regression Analysis KW - Humans KW - Exercise KW - Alcohol Drinking KW - Vitamin E -- blood KW - Cross-Sectional Studies KW - Carotenoids -- blood KW - Adult KW - Middle Aged KW - Ascorbic Acid -- blood KW - Diet KW - Female KW - Male KW - Antioxidants -- analysis KW - DNA Damage KW - European Continental Ancestry Group KW - Oxidative Stress KW - African Americans KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69902945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+research+%28New+York%2C+N.Y.%29&rft.atitle=Correlates+of+antioxidant+nutrients+and+oxidative+DNA+damage+differ+by+race+in+a+cross-sectional+study+of+healthy+African+American+and+white+adults.&rft.au=Watters%2C+Joanne+L%3BSatia%2C+Jessie+A%3BKupper%2C+Lawrence+L&rft.aulast=Watters&rft.aufirst=Joanne&rft.date=2008-09-01&rft.volume=28&rft.issue=9&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Nutrition+research+%28New+York%2C+N.Y.%29&rft.issn=1879-0739&rft_id=info:doi/10.1016%2Fj.nutres.2008.06.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-09 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Diet Assoc. 2007 Nov;107(11):1895-902 [17964308] J Nutr. 2007 Oct;137(10):2297-303 [17885014] Ethn Dis. 2000 Spring-Summer;10(2):208-17 [10892827] Cancer Epidemiol Biomarkers Prev. 2000 Jul;9(7):647-52 [10919732] Prev Med. 2000 Oct;31(4):380-9 [11006063] Am J Clin Nutr. 2001 Apr;73(4):777-85 [11273853] Mutat Res. 2001 Apr 18;475(1-2):7-20 [11295149] Mech Ageing Dev. 2001 Jun;122(8):835-47 [11337012] Community Genet. 1998;1(4):213-22 [11658005] Am J Health Promot. 2001 Nov-Dec;16(2):69-78 [11727591] Am J Epidemiol. 2002 Aug 1;156(3):274-85 [12142263] Am J Clin Nutr. 2002 Aug;76(2):303-10 [12144999] Crit Rev Clin Lab Sci. 2002 Sep;39(4-5):331-457 [12385502] AACN Clin Issues. 2002 Nov;13(4):540-9 [12473916] J Nutr. 2003 Mar;133 Suppl 3:933S-940S [12612179] Prev Med. 2003 Mar;36(3):379-87 [12634029] Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):747-54 [12917206] Mutat Res. 2003 Aug 5;539(1-2):9-18 [12948810] Clin Chem. 1988 Jan;34(1):44-8 [3338183] Carcinogenesis. 1992 Dec;13(12):2241-7 [1473230] Cancer Res. 1994 Apr 1;54(7 Suppl):1918s-1923s [8137312] Prev Med. 1995 May;24(3):221-8 [7644443] Am J Clin Nutr. 1995 Dec;62(6 Suppl):1427S-1430S [7495243] Am J Public Health. 1995 Dec;85(12):1623-9 [7503335] Environ Health Perspect. 1996 May;104 Suppl 3:465-9 [8781365] Environ Mol Mutagen. 1997;30(2):139-46 [9329638] FASEB J. 1998 Oct;12(13):1397-400 [9761783] Am J Clin Nutr. 1998 Oct;68(4):899-917 [9771869] J Am Diet Assoc. 1998 Dec;98(12):1412-7 [9850109] Am J Public Health. 1999 Sep;89(9):1390-6 [10474558] J Clin Invest. 1999 Sep;104(6):805-13 [10491416] J Natl Cancer Inst. 2004 Dec 1;96(23):1743-50 [15572756] FASEB J. 2005 Jan;19(1):82-4 [15533950] Am J Clin Nutr. 2005 Jan;81(1 Suppl):261S-267S [15640489] Eur J Clin Nutr. 2005 Oct;59(10):1181-90 [16034362] Br J Nutr. 2006 Feb;95(2):358-65 [16469154] Am J Epidemiol. 2006 Apr 15;163(8):770-8 [16524958] Am J Clin Nutr. 2006 Jul;84(1):88-94 [16825685] Am J Clin Nutr. 2006 Aug;84(2):375-83 [16895886] Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1428-36 [17627008] J Am Diet Assoc. 2008 Mar;108(3):529-33 [18313435] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.nutres.2008.06.005 ER - TY - JOUR T1 - Combining mTOR inhibition with metronomic chemotherapy in targeting angiogenesis. AN - 69706501; 18769127 JF - Cancer biology & therapy AU - Chau, Cindy H AU - Wang, Weixin AU - Figg, William D AD - Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1386 EP - 1387 VL - 7 IS - 9 KW - Carrier Proteins KW - 0 KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Vascular Endothelial Growth Factor A KW - Cyclophosphamide KW - 8N3DW7272P KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Phosphotransferases (Alcohol Group Acceptor) KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Vascular Endothelial Growth Factor A -- biosynthesis KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Humans KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Phosphotransferases (Alcohol Group Acceptor) -- antagonists & inhibitors KW - Stomach Neoplasms -- metabolism KW - Cyclophosphamide -- therapeutic use KW - Stomach Neoplasms -- blood supply KW - Carrier Proteins -- antagonists & inhibitors KW - Stomach Neoplasms -- genetics KW - Neovascularization, Pathologic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69706501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Combining+mTOR+inhibition+with+metronomic+chemotherapy+in+targeting+angiogenesis.&rft.au=Chau%2C+Cindy+H%3BWang%2C+Weixin%3BFigg%2C+William+D&rft.aulast=Chau&rft.aufirst=Cindy&rft.date=2008-09-01&rft.volume=7&rft.issue=9&rft.spage=1386&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=1555-8576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-09 N1 - Date created - 2008-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cancer Biol Ther. 2008 Sep;7(9):1377-85 [18708754] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits. AN - 69677587; 18471886 AB - We have previously reported that a single injection of endotoxin, lipopolysaccharide (LPS, 5mg/kg, i.p.), causes a delayed and progressive loss of TH-IR neurons in the substantia nigra (SN) in C57BL/six male mice. In this study, we determined sex differences and behavioral deficits accompanying the loss of TH-IR neurons in response to peripheral LPS injection. A single injection of LPS (5mg/kg, i.p.) failed to produce any loss of TH-IR neurons in the SN of female mice over a 12-month period. To determine if multiple-injections were required, female mice received five injections of LPS (5mg/kg, i.p.) at either weekly or monthly intervals. Behavioral motor ability and TH-IR neuronal loss were determined after the first injection of LPS. We found significant differences in both behavioral activities and neuronal loss between these two injection paradigms. Between 7 and 20 months after the first injection of LPS, progressive behavioral changes, measured by rotor-rod and open-field activities, and neuronal loss in SN were observed in monthly injected, but not in weekly injected mice. In addition, reduced rotor-rod ability in monthly injected mice were restored following treatment of l-dopa/carbidopa (30 mg/3mg/kg), i.p.). Approximately 40 and 50% loss of TH-IR neurons at 9 and 20 months, respectively, was observed after exposure to LPS, suggesting that the behavioral deficit is related to loss of dopamine function in the nigra-striatal pathway. More intense immuno-staining of alpha-synuclein and inflammatory markers were detected in brain sections exposed to LPS. In conclusion, these results show that multi-LPS monthly injections can induce a delayed and progressive loss of TH-IR neurons and motor deficits which resemble the progressive nature of Parkinson's disease. Further, the present study reveals a clear sex difference: female mice are more resistant to LPS than male mice. Repeated monthly LPS injections are required to cause both motor behavioral deficits and DA neuronal loss in female mice. JF - Neurotoxicology AU - Liu, Yuxin AU - Qin, Liya AU - Wilson, Belinda AU - Wu, Xuefei AU - Qian, Li AU - Granholm, Ann-Charlotte AU - Crews, Fulton T AU - Hong, Jau-Shyong AD - Neuropharmacology Section, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 864 EP - 870 VL - 29 IS - 5 SN - 0161-813X, 0161-813X KW - Dopamine Agents KW - 0 KW - Endotoxins KW - Lipopolysaccharides KW - Levodopa KW - 46627O600J KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Index Medicus KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Analysis of Variance KW - Sex Factors KW - Lipopolysaccharides -- pharmacology KW - Dopamine Agents -- pharmacology KW - Mice KW - Levodopa -- pharmacology KW - Exploratory Behavior -- drug effects KW - Rotarod Performance Test KW - Mice, Inbred C57BL KW - Time Factors KW - Female KW - Male KW - Neurons -- drug effects KW - Substantia Nigra -- drug effects KW - Motor Activity -- drug effects KW - Endotoxins -- toxicity KW - Substantia Nigra -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69677587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Endotoxin+induces+a+delayed+loss+of+TH-IR+neurons+in+substantia+nigra+and+motor+behavioral+deficits.&rft.au=Liu%2C+Yuxin%3BQin%2C+Liya%3BWilson%2C+Belinda%3BWu%2C+Xuefei%3BQian%2C+Li%3BGranholm%2C+Ann-Charlotte%3BCrews%2C+Fulton+T%3BHong%2C+Jau-Shyong&rft.aulast=Liu&rft.aufirst=Yuxin&rft.date=2008-09-01&rft.volume=29&rft.issue=5&rft.spage=864&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2008.02.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2008-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2001 Mar 15;21(6):1809-18 [11245665] Nat Neurosci. 2000 Dec;3(12):1301-6 [11100151] Mov Disord. 2002 Jan;17(1):116-24 [11835448] Bioessays. 2002 Apr;24(4):308-18 [11948617] J Neurochem. 2002 Jun;81(6):1285-97 [12068076] Trends Endocrinol Metab. 2002 Aug;13(6):229-30 [12128278] Trends Mol Med. 2003 Aug;9(8):360-5 [12928038] J Biol Chem. 2004 Jan 9;279(2):1415-21 [14578353] Annu Rev Physiol. 2004;66:291-313 [14977405] Endocrinology. 2004 Nov;145(11):5021-32 [15256495] J Neurochem. 1985 Jan;44(1):117-27 [3880581] J Clin Invest. 1991 Nov;88(5):1747-54 [1939659] Arch Surg. 1994 Feb;129(2):187-92 [8304829] J Neurosci. 1997 Feb 1;17(3):1168-78 [8994069] Exp Brain Res. 1997 Aug;116(1):29-38 [9305812] Ann N Y Acad Sci. 1998 May 30;844:153-65 [9668673] Biochem Biophys Res Commun. 1998 Jul 30;248(3):660-3 [9703982] Brain Res Mol Brain Res. 2005 Mar 24;134(1):109-18 [15790535] Ann N Y Acad Sci. 2005 Aug;1053:151-2 [16179518] Exp Neurol. 2006 Jun;199(2):499-512 [16504177] J Leukoc Biol. 2006 Oct;80(4):731-41 [16885502] Exp Neurol. 2006 Dec;202(2):336-47 [16889771] Crit Care. 2006;10(5):233 [17044947] Neurotoxicology. 2006 Dec;27(6):1110-22 [16815551] Ann N Y Acad Sci. 2006 Nov;1089:276-81 [17261775] Glia. 2007 Apr 1;55(5):453-62 [17203472] Gend Med. 2007 Mar;4(1):8-18 [17584622] J Endotoxin Res. 2007;13(3):158-66 [17621558] Exp Gerontol. 2000 Dec;35(9-10):1309-16 [11113609] Endocrinology. 2000 Oct;141(10):3646-56 [11014219] J Neuroimmunol. 2000 Nov 1;111(1-2):77-85 [11063824] Adv Neurol. 2001;86:55-72 [11554010] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuro.2008.02.014 ER - TY - JOUR T1 - DNA methylation: its role in cancer development and therapy. AN - 69672106; 18926282 JF - Current problems in cancer AU - Kurkjian, Carla AU - Kummar, Shivaani AU - Murgo, Anthony J AD - Advanced Developmental Therapeutics Training Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA. PY - 2008 SP - 187 EP - 235 VL - 32 IS - 5 KW - Antimetabolites, Antineoplastic KW - 0 KW - Biomarkers, Tumor KW - decitabine KW - 776B62CQ27 KW - DNA Modification Methylases KW - EC 2.1.1.- KW - Protein Methyltransferases KW - Histone Acetyltransferases KW - EC 2.3.1.48 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Animals KW - Biomarkers, Tumor -- genetics KW - Azacitidine -- therapeutic use KW - Humans KW - Azacitidine -- analogs & derivatives KW - DNA Modification Methylases -- antagonists & inhibitors KW - Inflammation -- genetics KW - Protein Methyltransferases -- metabolism KW - Disease -- genetics KW - Protein Methyltransferases -- antagonists & inhibitors KW - Aging -- physiology KW - Biomarkers, Tumor -- physiology KW - Histone Acetyltransferases -- metabolism KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Histone Acetyltransferases -- antagonists & inhibitors KW - Aging -- genetics KW - Cell Transformation, Neoplastic -- genetics KW - DNA Methylation -- physiology KW - Neoplasms -- therapy KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69672106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+problems+in+cancer&rft.atitle=DNA+methylation%3A+its+role+in+cancer+development+and+therapy.&rft.au=Kurkjian%2C+Carla%3BKummar%2C+Shivaani%3BMurgo%2C+Anthony+J&rft.aulast=Kurkjian&rft.aufirst=Carla&rft.date=2008-09-01&rft.volume=32&rft.issue=5&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Current+problems+in+cancer&rft.issn=1535-6345&rft_id=info:doi/10.1016%2Fj.currproblcancer.2008.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-07 N1 - Date created - 2008-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2002 Nov 15;62(22):6390-4 [12438221] 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AN - 69650294; 18671702 AB - In addition to vaso-occlusion by sickled erythrocytes, the pathophysiology of sickle cell disease (SCD) is compounded by the diminished bioavailability of nitric oxide (NO), associated with vasoconstriction, endothelial activation and cell adhesion. We tested the ability of sodium nitrite, which can be converted to NO by deoxyhaemoglobin at acid pH and low oxygen tension, to improve blood flow in patients with SCD. In a phase I/II clinical trial, sodium nitroprusside, NG-monomethyl-L-arginine, and sodium nitrite were infused sequentially into the brachial artery in 14 patients at steady state. In a dose-dependent manner, sodium nitrite infusion rates of 0.4, 4 and 40 micromol/min into the brachial artery augmented mean venous plasma nitrite concentrations (P < 0.0001) and stimulated forearm blood flow up to 77 +/- 11% above baseline (P < 0.0001), measured by venous occlusion strain gauge plethysmography. This nitrite response was blunted significantly compared to controls without SCD, as previously seen with other NO donors. Sodium nitrite infusions were well tolerated without hypotension, clinically significant methaemoglobinaemia or other untoward events. The unique pharmacological properties of nitrite as a hypoxia-potentiated vasodilator and cytoprotective agent in the setting of ischaemia-reperfusion injury make this anion a plausible NO donor for future clinical trials in SCD. JF - British journal of haematology AU - Mack, A Kyle AU - McGowan Ii, Vicki R AU - Tremonti, Carole K AU - Ackah, Diana AU - Barnett, Christopher AU - Machado, Roberto F AU - Gladwin, Mark T AU - Kato, Gregory J AD - Pulmonary and Vascular Medicine Branch, National Heart, Lung and Blood Institute; National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 971 EP - 978 VL - 142 IS - 6 KW - Nitric Oxide Donors KW - 0 KW - Vasodilator Agents KW - Nitroprusside KW - 169D1260KM KW - Sodium Nitrite KW - M0KG633D4F KW - Index Medicus KW - Forearm -- blood supply KW - Young Adult KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Regional Blood Flow -- drug effects KW - Vasodilation -- drug effects KW - Middle Aged KW - Sodium Nitrite -- blood KW - Sodium Nitrite -- therapeutic use KW - Sodium Nitrite -- pharmacology KW - Sodium Nitrite -- adverse effects KW - Vasodilator Agents -- adverse effects KW - Vasodilator Agents -- therapeutic use KW - Anemia, Sickle Cell -- blood KW - Anemia, Sickle Cell -- physiopathology KW - Anemia, Sickle Cell -- drug therapy KW - Vasodilator Agents -- blood KW - Vasodilator Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69650294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Sodium+nitrite+promotes+regional+blood+flow+in+patients+with+sickle+cell+disease%3A+a+phase+I%2FII+study.&rft.au=Mack%2C+A+Kyle%3BMcGowan+Ii%2C+Vicki+R%3BTremonti%2C+Carole+K%3BAckah%2C+Diana%3BBarnett%2C+Christopher%3BMachado%2C+Roberto+F%3BGladwin%2C+Mark+T%3BKato%2C+Gregory+J&rft.aulast=Mack&rft.aufirst=A&rft.date=2008-09-01&rft.volume=142&rft.issue=6&rft.spage=971&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=1365-2141&rft_id=info:doi/10.1111%2Fj.1365-2141.2008.07259.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-11 N1 - Date created - 2008-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Circulation. 2003 Jan 21;107(2):271-8 [12538427] Blood. 2003 May 15;101(10):3953-9 [12543857] Am J Hematol. 2003 Oct;74(2):104-11 [14508796] J Thromb Haemost. 2003 Oct;1(10):2112-8 [14521592] Nat Med. 2003 Dec;9(12):1498-505 [14595407] N Engl J Med. 2004 Feb 26;350(9):886-95 [14985486] Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13683-8 [15347817] Nat Med. 2004 Oct;10(10):1122-7 [15361865] Lancet. 2004 Oct 9-15;364(9442):1343-60 [15474138] J Clin Invest. 2004 Oct;114(8):1136-45 [15489961] Br J Haematol. 2005 Jan;128(2):266-72 [15638863] JAMA. 2005 Mar 23;293(12):1477-84 [15784871] J Clin Invest. 2005 May;115(5):1232-40 [15841216] Blood. 2005 Jul 15;106(2):734-9 [15774613] JAMA. 2005 Jul 6;294(1):81-90 [15998894] J Clin Invest. 2005 Aug;115(8):2099-107 [16041407] Blood. 2005 Nov 1;106(9):3264-7 [15985542] Methods Enzymol. 2005;396:553-68 [16291262] Blood. 2006 Jan 15;107(2):566-74 [16195332] Blood. 2006 Mar 15;107(6):2279-85 [16291595] Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H379-84 [16443673] Free Radic Biol Med. 2006 Aug 15;41(4):541-8 [16863986] Stroke. 2006 Nov;37(11):2744-50 [17008610] Blood Rev. 2007 Jan;21(1):37-47 [17084951] Blood. 2007 Apr 1;109(7):3088-98 [17158223] Haematologica. 2007 Dec;92(12):1709-10 [18055999] Am J Physiol Heart Circ Physiol. 2000 Jun;278(6):H1799-806 [10843875] Nat Med. 2002 Dec;8(12):1383-9 [12426562] Blood. 2001 Mar 15;97(6):1584-9 [11238095] Am J Physiol Regul Integr Comp Physiol. 2000 Dec;279(6):R1949-55 [11080057] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2141.2008.07259.x ER - TY - JOUR T1 - Ethical and psychological considerations in fertility preservation counseling. AN - 69636484; 18836341 JF - Cancer journal (Sudbury, Mass.) AU - Browne, Hyacinth AU - Nurudeen, Sahadat AU - Armstrong, Alicia AU - Decherney, Alan AD - Program in Reproductive and Adult Endocrinology, NICHD, NIH, Bethesda, Maryland 20892, USA.brownehy@mail.nih.gov PY - 2008 SP - 340 EP - 342 VL - 14 IS - 5 SN - 1528-9117, 1528-9117 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - Survivors -- psychology KW - Cryopreservation KW - Male KW - Female KW - Radiotherapy -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Infertility -- prevention & control KW - Neoplasms -- complications KW - Ethics, Medical KW - Neoplasms -- psychology KW - Neoplasms -- therapy KW - Infertility -- etiology KW - Counseling KW - Infertility -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69636484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.atitle=Ethical+and+psychological+considerations+in+fertility+preservation+counseling.&rft.au=Browne%2C+Hyacinth%3BNurudeen%2C+Sahadat%3BArmstrong%2C+Alicia%3BDecherney%2C+Alan&rft.aulast=Browne&rft.aufirst=Hyacinth&rft.date=2008-09-01&rft.volume=14&rft.issue=5&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.issn=15289117&rft_id=info:doi/10.1097%2FPPO.0b013e3181897ee0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-13 N1 - Date created - 2008-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cancer J. 2008 Sep-Oct;14(5):333-9 [18836340] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/PPO.0b013e3181897ee0 ER - TY - JOUR T1 - Contemporary epidemiology of renal cell cancer. AN - 69632766; 18836333 AB - We analyzed renal cell cancer incidence patterns in the United States and reviewed recent epidemiologic evidence with regard to environmental and host genetic determinants of renal cell cancer risk. Renal cell cancer incidence rates continued to rise among all racial/ethnic groups in the United States, across all age groups, and for all tumor sizes, with the most rapid increases for localized stage disease and small tumors. Recent cohort studies confirmed the association of smoking, excess body weight, and hypertension with an elevated risk of renal cell cancer, and suggested that these factors can be modified to reduce the risk. There is increasing evidence for an inverse association between renal cell cancer risk and physical activity and moderate intake of alcohol. Occupational exposure to trichloroethylene has been positively associated with renal cell cancer risk in several recent studies, but its link with somatic mutations of the von Hippel-Lindau gene has not been confirmed. Studies of genetic polymorphisms in relation to renal cell cancer risk have produced mixed results, but genome-wide association studies with larger sample size and a more comprehensive approach are underway. Few epidemiologic studies have evaluated risk factors by subtypes of renal cell cancer defined by somatic mutations and other tumor markers. JF - Cancer journal (Sudbury, Mass.) AU - Chow, Wong-Ho AU - Devesa, Susan S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-7240, USA. choww@mail.nih.gov PY - 2008 SP - 288 EP - 301 VL - 14 IS - 5 SN - 1528-9117, 1528-9117 KW - Antihypertensive Agents KW - 0 KW - Biomarkers, Tumor KW - Gonadal Steroid Hormones KW - Index Medicus KW - Parity KW - Environment KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Continental Population Groups KW - Smoking -- adverse effects KW - Pregnancy KW - Obesity -- complications KW - Age Distribution KW - Hypertension -- drug therapy KW - Hypertension -- complications KW - Survival Rate KW - Risk Factors KW - Motor Activity KW - Incidence KW - Diet KW - Genetic Predisposition to Disease KW - Occupations KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Kidney Neoplasms -- genetics KW - Kidney Neoplasms -- diagnosis KW - Carcinoma, Renal Cell -- diagnosis KW - Kidney Neoplasms -- epidemiology KW - Carcinoma, Renal Cell -- genetics KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69632766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.atitle=Contemporary+epidemiology+of+renal+cell+cancer.&rft.au=Chow%2C+Wong-Ho%3BDevesa%2C+Susan+S&rft.aulast=Chow&rft.aufirst=Wong-Ho&rft.date=2008-09-01&rft.volume=14&rft.issue=5&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.issn=15289117&rft_id=info:doi/10.1097%2FPPO.0b013e3181867628 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-13 N1 - Date created - 2008-10-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Occup Environ Med. 2004 Mar;46(3):235-40 [15091286] EMBO J. 2004 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http://dx.doi.org/10.1097/PPO.0b013e3181867628 ER - TY - JOUR T1 - Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration. AN - 69584843; 18804434 AB - During acute stress in the endoplasmic reticulum (ER), mammalian prion protein (PrP) is temporarily prevented from translocation into the ER and instead routed directly for cytosolic degradation. This "pre-emptive" quality control (pQC) system benefits cells by minimizing PrP aggregation in the secretory pathway during ER stress. However, the potential toxicity of cytosolic PrP raised the possibility that persistent pQC of PrP contributes to neurodegeneration in prion diseases. Here, we find evidence of ER stress and decreased translocation of nascent PrP during prion infection. Transgenic mice expressing a PrP variant with reduced translocation at levels expected during ER stress was sufficient to cause several mild age-dependent clinical and histological manifestations of PrP-mediated neurodegeneration. Thus, an ordinarily adaptive quality-control pathway can be contextually detrimental over long time periods. We propose that one mechanism of prion-mediated neurodegeneration involves an indirect ER stress-dependent effect on nascent PrP biosynthesis and metabolism. JF - Developmental cell AU - Rane, Neena S AU - Kang, Sang-Wook AU - Chakrabarti, Oishee AU - Feigenbaum, Lionel AU - Hegde, Ramanujan S AD - Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 359 EP - 370 VL - 15 IS - 3 KW - PrPSc Proteins KW - 0 KW - Prions KW - Protein Sorting Signals KW - Recombinant Fusion Proteins KW - Index Medicus KW - Animals KW - Brain -- cytology KW - Cricetulus KW - Protein Sorting Signals -- genetics KW - Amino Acid Sequence KW - Brain -- metabolism KW - Mice KW - Mice, Transgenic KW - Scrapie -- metabolism KW - Recombinant Fusion Proteins -- metabolism KW - Brain -- pathology KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Biological Transport -- physiology KW - Cricetinae KW - Endoplasmic Reticulum -- metabolism KW - Prions -- genetics KW - Nerve Degeneration -- metabolism KW - Oxidative Stress KW - Nerve Degeneration -- pathology KW - PrPSc Proteins -- metabolism KW - PrPSc Proteins -- genetics KW - Prions -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69584843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+cell&rft.atitle=Reduced+translocation+of+nascent+prion+protein+during+ER+stress+contributes+to+neurodegeneration.&rft.au=Rane%2C+Neena+S%3BKang%2C+Sang-Wook%3BChakrabarti%2C+Oishee%3BFeigenbaum%2C+Lionel%3BHegde%2C+Ramanujan+S&rft.aulast=Rane&rft.aufirst=Neena&rft.date=2008-09-01&rft.volume=15&rft.issue=3&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Developmental+cell&rft.issn=1878-1551&rft_id=info:doi/10.1016%2Fj.devcel.2008.06.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-13 N1 - Date created - 2008-09-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1999 Dec 16;402(6763):822-6 [10617204] EMBO J. 2000 Dec 1;19(23):6440-52 [11101517] Dev Cell. 2002 Feb;2(2):207-17 [11832246] Mol Biol Cell. 2002 Nov;13(11):3775-86 [12429823] J Cell Biol. 2003 Feb 17;160(4):529-39 [12578908] J Biol Chem. 2003 Jun 13;278(24):21732-43 [12663673] EMBO J. 2003 Oct 15;22(20):5435-45 [14532116] J Biol Chem. 2003 Oct 17;278(42):40877-81 [12917444] Science. 2003 Oct 31;302(5646):871-4 [14593181] J Biol Chem. 2003 Nov 14;278(46):45960-8 [12933795] Protein Sci. 1992 Aug;1(8):986-97 [1338978] Nature. 1996 Jan 25;379(6563):339-43 [8552188] J Cell Biol. 1996 Jul;134(1):25-35 [8698819] Science. 1998 Feb 6;279(5352):827-34 [9452375] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13363-83 [9811807] Mol Cell Neurosci. 1998 Dec;12(6):363-75 [9888989] EMBO J. 2004 Nov 24;23(23):4550-9 [15526034] Mol Biol Cell. 2005 Jan;16(1):279-91 [15496459] J Neurosci. 2005 Mar 16;25(11):2793-802 [15772339] J Biol Chem. 2005 Mar 25;280(12):11320-8 [15632159] Nat Cell Biol. 2005 Aug;7(8):766-72 [16056268] Nat Genet. 2005 Sep;37(9):974-9 [16116427] Curr Mol Med. 2006 Feb;6(1):37-43 [16472111] Cell Death Differ. 2006 Mar;13(3):385-92 [16397584] Cell. 2006 May 5;125(3):443-51 [16678092] J Biol Chem. 2006 Oct 13;281(41):30431-8 [16908519] Cell. 2006 Dec 1;127(5):999-1013 [17129784] Neuron. 2007 Feb 1;53(3):325-35 [17270731] Mol Cell. 2007 Apr 27;26(2):175-88 [17466621] Science. 2007 Nov 9;318(5852):930-6 [17991853] Comment In: Dev Cell. 2008 Sep;15(3):339-41 [18804431] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.devcel.2008.06.015 ER - TY - JOUR T1 - The inverse relationship between chronic HBV and HCV infections among injection drug users is associated with decades of age and drug use. AN - 69584235; 18507757 AB - Infection with hepatitis C virus (HCV) may suppress co-infection with hepatitis B virus (HBV) during acute or chronic HBV infection. We examined relationships between HBV infection, HCV infection and other factors among injection drug users (IDUs) with antibodies to both viruses. Participants enrolled in a cross-sectional study during 1998-2000 were considered to have been infected with HBV if they had core antibody, to be chronically infected if they had hepatitis B surface antigen (HBsAg), to have been infected with HCV if they had HCV antibody and to be chronically infected if they had HCV RNA. Among 1694 participants with antibody to both viruses, HBsAg prevalence decreased with increasing age among those positive for HCV RNA [from 4.55% in those 18-29 years to 1.03% in those >or=50 years old (P(trend) = 0.02)], but not among those who were negative for HCV RNA. Chronic HBV infection was less common overall among those with chronic HCV infection (odds ratio [OR], 0.25; P 50 years; OR = 0.15) than the youngest (18-29 years; OR = 0.81) participants (P(trend) = 0.03). Similar results were obtained when duration of injection drug use was substituted for age (P(trend) = 0.05). Among IDUs who have acquired both HBV and HCV, chronic HBV infection is much less common among those with chronic HCV infection, but this inverse relationship increases markedly with increasing years of age and injection drug use. Co-infection with HCV may enhance the resolution of HBsAg during the chronic phases of these infections. JF - Journal of viral hepatitis AU - Tseng, F-C AU - Edlin, B R AU - Zhang, M AU - Kral, A AU - Busch, M P AU - Ortiz-Conde, B A AU - Welzel, T M AU - O'Brien, T R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-4605, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 690 EP - 698 VL - 15 IS - 9 KW - Hepatitis B Antibodies KW - 0 KW - Hepatitis B Surface Antigens KW - Hepatitis C Antibodies KW - Pharmaceutical Preparations KW - RNA, Viral KW - Index Medicus KW - Age Factors KW - Hepatitis C Antibodies -- blood KW - Humans KW - Child KW - Hepatitis B Surface Antigens -- blood KW - Cross-Sectional Studies KW - Adult KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - RNA, Viral -- blood KW - Hepatitis B Antibodies -- blood KW - Hepatitis C, Chronic -- epidemiology KW - Substance Abuse, Intravenous -- complications KW - Hepatitis B -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69584235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+viral+hepatitis&rft.atitle=The+inverse+relationship+between+chronic+HBV+and+HCV+infections+among+injection+drug+users+is+associated+with+decades+of+age+and+drug+use.&rft.au=Tseng%2C+F-C%3BEdlin%2C+B+R%3BZhang%2C+M%3BKral%2C+A%3BBusch%2C+M+P%3BOrtiz-Conde%2C+B+A%3BWelzel%2C+T+M%3BO%27Brien%2C+T+R&rft.aulast=Tseng&rft.aufirst=F-C&rft.date=2008-09-01&rft.volume=15&rft.issue=9&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Journal+of+viral+hepatitis&rft.issn=1365-2893&rft_id=info:doi/10.1111%2Fj.1365-2893.2008.01005.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-23 N1 - Date created - 2008-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2893.2008.01005.x ER - TY - JOUR T1 - Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. AN - 69578662; 18566332 AB - Embryonic stem cells need to maintain genomic integrity so that they can retain the ability to differentiate into multiple cell types without propagating DNA errors. Previous studies have suggested that mechanisms of genome surveillance, including DNA repair, are superior in mouse embryonic stem cells compared with various differentiated murine cells. Using single-cell gel electrophoresis (comet assay) we found that human embryonic stem cells (BG01, I6) have more efficient repair of different types of DNA damage (generated from H2O2, UV-C, ionizing radiation, or psoralen) than human primary fibroblasts (WI-38, hs27) and, with the exception of UV-C damage, HeLa cells. Microarray gene expression analysis showed that mRNA levels of several DNA repair genes are elevated in human embryonic stem cells compared with their differentiated forms (embryoid bodies). These data suggest that genomic maintenance pathways are enhanced in human embryonic stem cells, relative to differentiated human cells. JF - Stem cells (Dayton, Ohio) AU - Maynard, Scott AU - Swistowska, Anna Maria AU - Lee, Jae Wan AU - Liu, Ying AU - Liu, Su-Ting AU - Da Cruz, Alexandre Bettencourt AU - Rao, Mahendra AU - de Souza-Pinto, Nadja C AU - Zeng, Xianmin AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Box 1, 5600 Nathan Shock Drive, Baltimore, Maryland 21224-6825, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 2266 EP - 2274 VL - 26 IS - 9 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Ficusin KW - KTZ7ZCN2EX KW - Index Medicus KW - Ficusin -- pharmacology KW - Fibroblasts -- drug effects KW - Comet Assay KW - Ultraviolet Rays KW - Oligonucleotide Array Sequence Analysis KW - HeLa Cells KW - Humans KW - Hydrogen Peroxide -- pharmacology KW - Cell Differentiation KW - Fibroblasts -- radiation effects KW - Fibroblasts -- cytology KW - Radiation, Ionizing KW - Embryonic Stem Cells -- drug effects KW - Embryonic Stem Cells -- cytology KW - DNA Repair KW - Embryonic Stem Cells -- radiation effects KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69578662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+cells+%28Dayton%2C+Ohio%29&rft.atitle=Human+embryonic+stem+cells+have+enhanced+repair+of+multiple+forms+of+DNA+damage.&rft.au=Maynard%2C+Scott%3BSwistowska%2C+Anna+Maria%3BLee%2C+Jae+Wan%3BLiu%2C+Ying%3BLiu%2C+Su-Ting%3BDa+Cruz%2C+Alexandre+Bettencourt%3BRao%2C+Mahendra%3Bde+Souza-Pinto%2C+Nadja+C%3BZeng%2C+Xianmin%3BBohr%2C+Vilhelm+A&rft.aulast=Maynard&rft.aufirst=Scott&rft.date=2008-09-01&rft.volume=26&rft.issue=9&rft.spage=2266&rft.isbn=&rft.btitle=&rft.title=Stem+cells+%28Dayton%2C+Ohio%29&rft.issn=1549-4918&rft_id=info:doi/10.1634%2Fstemcells.2007-1041 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-11 N1 - Date created - 2008-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Soc Trans. 2001 May;29(Pt 2):196-201 [11356153] Annu Rev Med. 2005;56:495-508 [15660524] Mech Ageing Dev. 2001 Sep 30;122(14):1537-53 [11511395] Annu Rev Biochem. 2005;74:681-710 [15952900] Nucleic Acids Res. 2005;33(17):5382-93 [16186129] Mutat Res. 2005 Dec 11;591(1-2):45-59 [16054172] Cancer Res. 2005 Dec 15;65(24):11704-11 [16357182] Stem Cells. 2006 Mar;24(3):516-30 [16293578] J Biol Chem. 2001 Dec 7;276(49):45772-9 [11581270] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3586-90 [11891338] Lancet Oncol. 2001 Aug;2(8):483-90 [11905724] Free Radic Biol Med. 2002 May 1;32(9):804-12 [11978482] Methods Mol Biol. 2002;203:179-94 [12073441] FASEB J. 2003 Jul;17(10):1195-214 [12832285] Biochimie. 2003 Nov;85(11):1083-99 [14726015] Mol Biotechnol. 2004 Mar;26(3):249-61 [15004294] Genes Dev. 2004 Mar 15;18(6):602-16 [15075289] Stem Cells. 2004;22(3):292-312 [15153607] Mol Pharmacol. 2004 Jun;65(6):1496-506 [15155842] Cytogenet Genome Res. 2004;104(1-4):14-20 [15162010] Annu Rev Biochem. 2004;73:39-85 [15189136] Nucleic Acids Res. 1988 Feb 11;16(3):1215 [3344216] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Exp Cell Res. 1992 Feb;198(2):259-67 [1370267] Mol Gen Genet. 1993 May;239(1-2):72-6 [8510665] Somat Cell Mol Genet. 1993 May;19(3):245-55 [8332932] Methods Enzymol. 1996;269:243-66 [8791654] Cancer Res. 1996 Dec 15;56(24):5533-46 [8971150] Genes Cells. 1998 Mar;3(3):135-44 [9619626] Free Radic Res. 1998 Dec;29(6):573-9 [10098461] Nucleic Acids Res. 1999 Apr 15;27(8):1935-42 [10101204] Nucleic Acids Res. 1999 Aug 15;27(16):3276-82 [10454634] Nucleic Acids Res. 2006;34(9):2751-60 [16714450] BMC Dev Biol. 2006;6:20 [16672070] Cardiovasc Revasc Med. 2006 Jul-Sep;7(3):165-72 [16945824] J Biol Chem. 2006 Oct 13;281(41):30305-9 [16905530] Mutat Res. 2007 Jan 3;614(1-2):48-55 [16914171] Cell Cycle. 2006 Dec;5(24):2886-8 [17172862] Mech Ageing Dev. 2007 Jan;128(1):137-48 [17134742] Mol Carcinog. 2007 Feb;46(2):91-9 [17013835] DNA Repair (Amst). 2007 Apr 1;6(4):544-59 [17112792] Bioconjug Chem. 2007 Mar-Apr;18(2):431-7 [17373769] Radiat Prot Dosimetry. 2006;122(1-4):124-7 [17351270] Stem Cells. 2007 May;25(5):1298-306 [17272497] Nature. 2007 Jun 7;447(7145):686-90 [17554302] Nature. 2007 Jun 7;447(7145):725-9 [17554309] Cell Death Differ. 2007 Aug;14(8):1422-32 [17464330] Stem Cells. 2008 Feb;26(2):455-64 [18055443] Gen Physiol Biophys. 1999 Oct;18 Spec No:70-4 [10703722] Stem Cells. 2004;22(6):962-71 [15536187] Chembiochem. 2005 Jan;6(1):27-32 [15637664] Exp Gerontol. 2001 Jul;36(7):1049-62 [11404050] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/stemcells.2007-1041 ER - TY - JOUR T1 - Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters. AN - 69547133; 18790787 AB - Molecular and pharmacologic profiling of the NCI-60 cell panel offers the possibility of identifying pathways involved in drug resistance or sensitivity. Of these, decreased uptake of anticancer drugs mediated by efflux transporters represents one of the best studied mechanisms. Previous studies have also shown that uptake transporters can influence cytotoxicity by altering the cellular uptake of anticancer drugs. Using quantitative real-time PCR, we measured the mRNA expression of two solute carrier (SLC) families, the organic cation/zwitterion transporters (SLC22 family) and the organic anion transporters (SLCO family), totaling 23 genes in normal tissues and the NCI-60 cell panel. By correlating the mRNA expression pattern of the SLCO and SLC22 family member gene products with the growth-inhibitory profiles of 1,429 anticancer drugs and drug candidate compounds tested on the NCI-60 cell lines, we identified SLC proteins that are likely to play a dominant role in drug sensitivity. To substantiate some of the SLC-drug pairs for which the SLC member was predicted to be sensitizing, follow-up experiments were performed using engineered and characterized cell lines overexpressing SLC22A4 (OCTN1). As predicted by the statistical correlations, expression of SLC22A4 resulted in increased cellular uptake and heightened sensitivity to mitoxantrone and doxorubicin. Our results indicate that the gene expression database can be used to identify SLCO and SLC22 family members that confer sensitivity to cancer cells. JF - Molecular cancer therapeutics AU - Okabe, Mitsunori AU - Szakács, Gergely AU - Reimers, Mark A AU - Suzuki, Toshihiro AU - Hall, Matthew D AU - Abe, Takaaki AU - Weinstein, John N AU - Gottesman, Michael M AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 3081 EP - 3091 VL - 7 IS - 9 SN - 1535-7163, 1535-7163 KW - Antineoplastic Agents KW - 0 KW - Organic Anion Transporters KW - Organic Cation Transport Proteins KW - RNA, Messenger KW - SLC22A4 protein, human KW - Doxorubicin KW - 80168379AG KW - Mitoxantrone KW - BZ114NVM5P KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Doxorubicin -- chemistry KW - Reproducibility of Results KW - Mitoxantrone -- metabolism KW - Humans KW - Mitoxantrone -- pharmacology KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Mitoxantrone -- chemistry KW - Doxorubicin -- metabolism KW - Doxorubicin -- pharmacology KW - RNA, Messenger -- metabolism KW - Transfection KW - Inhibitory Concentration 50 KW - Gene Expression Profiling KW - Organic Anion Transporters -- genetics KW - Genes, Neoplasm KW - Organic Cation Transport Proteins -- metabolism KW - Antineoplastic Agents -- metabolism KW - Organic Cation Transport Proteins -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69547133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Profiling+SLCO+and+SLC22+genes+in+the+NCI-60+cancer+cell+lines+to+identify+drug+uptake+transporters.&rft.au=Okabe%2C+Mitsunori%3BSzak%C3%A1cs%2C+Gergely%3BReimers%2C+Mark+A%3BSuzuki%2C+Toshihiro%3BHall%2C+Matthew+D%3BAbe%2C+Takaaki%3BWeinstein%2C+John+N%3BGottesman%2C+Michael+M&rft.aulast=Okabe&rft.aufirst=Mitsunori&rft.date=2008-09-01&rft.volume=7&rft.issue=9&rft.spage=3081&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/10.1158%2F1535-7163.MCT-08-0539 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-22 N1 - Date created - 2008-09-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2006 May 1;66(9):4808-15 [16651436] Annu Rev Pharmacol Toxicol. 1999;39:361-98 [10331089] Nat Rev Cancer. 2006 Aug;6(8):583-92 [16862189] Cancer Res. 2006 Sep 1;66(17):8847-57 [16951202] J Pharmacol Exp Ther. 2006 Nov;319(2):879-86 [16914559] Mol Cancer Ther. 2006 Nov;5(11):2601-5 [17088435] Biochem Pharmacol. 2007 Jul 15;74(2):309-16 [17532304] Science. 2007 Nov 16;318(5853):1108-13 [17932254] Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3287-96 [18089722] Annu Rev Pharmacol Toxicol. 2008;48:495-535 [17937596] Nat Genet. 2000 Mar;24(3):236-44 [10700175] Gastroenterology. 2001 Jun;120(7):1689-99 [11375950] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10787-92 [11553813] Annu Rev Med. 2002;53:615-27 [11818492] Blood. 2004 Dec 1;104(12):3739-45 [15315971] Mol Cancer Ther. 2004 Dec;3(12):1543-9 [15634647] Biochem Biophys Res Commun. 2005 Aug 5;333(3):754-62 [15963465] Am J Pathol. 2005 Dec;167(6):1477-84 [16314463] Circulation. 2006 Feb 28;113(8):1114-22 [16490820] Nat Rev Drug Discov. 2006 Mar;5(3):219-34 [16518375] Mol Cancer Ther. 2006 Apr;5(4):853-67 [16648555] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 [12184808] Mol Pharmacol. 2002 Nov;62(5):1154-9 [12391279] Bioinformatics. 2003 Feb 12;19(3):368-75 [12584122] Genome Biol. 2003;4(12):R82 [14659019] Pflugers Arch. 2004 Feb;447(5):666-76 [12883891] Pflugers Arch. 2004 Feb;447(5):653-65 [14579113] Nat Genet. 2004 May;36(5):471-5 [15107849] Pharmacol Rev. 2004 Jun;56(2):185-229 [15169927] Cancer Res. 2004 Jun 15;64(12):4294-301 [15205344] Cancer Cell. 2004 Aug;6(2):129-37 [15324696] Curr Med Chem. 2004 Sep;11(18):2443-66 [15379707] Drug Metab Pharmacokinet. 2004 Jun;19(3):171-9 [15499184] J Natl Cancer Inst. 1989 Jul 19;81(14):1088-92 [2738938] Science. 1992 Oct 16;258(5081):447-51 [1411538] J Clin Invest. 1995 May;95(5):2205-14 [7738186] Science. 1997 Jan 17;275(5298):343-9 [8994024] FEBS Lett. 1997 Dec 8;419(1):107-11 [9426230] Cancer Lett. 2006 Aug 8;239(2):168-82 [16169662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-08-0539 ER - TY - JOUR T1 - Genetic approaches to addiction: genes and alcohol. AN - 69539089; 18422824 AB - Alcoholism is a chronic relapsing disorder with an enormous societal impact. Understanding the genetic basis of alcoholism is crucial to characterize individuals' risk and to develop efficacious prevention and treatment strategies. We examined the available scientific literature to provide an overview of different approaches that are being integrated increasingly to advance our knowledge of the genetic bases of alcoholism. Examples of genes that have been shown to influence vulnerability to alcoholism and related phenotypes are also discussed. Genetic factors account for more than 50% of the variance in alcoholism liability. Susceptibility loci for alcoholism include both alcohol-specific genes acting either at the pharmacokinetic or pharmacodynamic levels, as well as loci moderating neuronal pathways such as reward, behavioral control and stress resiliency, that are involved in several psychiatric diseases. In recent years, major progress in gene identification has occurred using intermediate phenotypes such as task-related brain activation that confer the advantage of increased power and the opportunity of exploring the neuronal mechanisms through which genetic variation is translated into behavior. Fundamental to the detection of gene effects is also the understanding of the interplay between genes as well as genes/environment interactions. Whole Genome Association studies represent a unique opportunity to identify alcohol-related loci in hypothesis-free fashion. Finally, genome-wide analyses of transcripts and chromatin remodeling promise an increase in our understanding of the genome function and of the mechanisms through which gene and environment cause diseases. Although the genetic bases of alcoholism remain largely unknown, there are reasons to think that more genes will be discovered in the future. Multiple and complementary approaches will be required to piece together the mosaic of causation. JF - Addiction (Abingdon, England) AU - Ducci, Francesca AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism/NIH, Rockville, MD 20892, USA. francesca.ducci@iop.kcl.ac.uk Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1414 EP - 1428 VL - 103 IS - 9 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Phenotype KW - Risk Factors KW - Humans KW - Twin Studies as Topic KW - Genetic Linkage -- genetics KW - Genetic Predisposition to Disease -- genetics KW - Alcoholism -- genetics KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69539089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Genetic+approaches+to+addiction%3A+genes+and+alcohol.&rft.au=Ducci%2C+Francesca%3BGoldman%2C+David&rft.aulast=Ducci&rft.aufirst=Francesca&rft.date=2008-09-01&rft.volume=103&rft.issue=9&rft.spage=1414&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02203.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-23 N1 - Date created - 2008-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroinformatics. 2006 Winter;4(1):51-64 [16595858] Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6269-74 [16569698] Alcohol Alcohol. 2000 May-Jun;35(3):242-8 [10869242] Arch Gen Psychiatry. 2000 Aug;57(8):803-11 [10920470] Am J Med Genet. 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Jul 18;301(5631):386-9 [12869766] Neuropsychopharmacology. 2003 Aug;28(8):1546-52 [12813472] Arch Gen Psychiatry. 2003 Sep;60(9):889-96 [12963670] Arch Gen Psychiatry. 2003 Sep;60(9):929-37 [12963675] Psychol Med. 2003 Oct;33(7):1211-22 [14580076] Mol Psychiatry. 2003 Nov;8(11):933-6 [14593431] Am J Hum Genet. 2006 May;78(5):815-26 [16642437] Psychol Med. 1999 Sep;29(5):1069-81 [10576299] Drug Alcohol Depend. 1999 Nov 1;57(1):69-78 [10617315] Alcohol Clin Exp Res. 2000 Feb;24(2):135-9 [10698363] Biol Psychiatry. 2000 Apr 1;47(7):643-9 [10745057] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02203.x ER - TY - JOUR T1 - Pharmacogenetic relevance of MTHFR polymorphisms. AN - 69535375; 18781847 AB - The 5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for intracellular folate homeostasis and metabolism. Two common MTHFR polymorphisms, C677T and A1298C, which lead to an altered amino acid sequence, have been associated with a decreased enzyme activity and susceptibility to cancer suggesting that these genetic variants may modulate the risk of several malignancies. C667T, and to a lesser extent A1298C polymorphisms, are also reported to influence the cytotoxic effect of fluoropyrimidines and antifolates providing support for their pharmacogenetic role in predicting the efficacy and the toxicity in cancer and rheumatoid arthritis patients. A combined polymorphisms and haplotype analysis may result in a more effective approach than a single polymorphism one. Moreover gene-nutrient/environmental and gene-racial/ethnic interactions have been shown to affect the impact of these MTHFR genetic variants. Further well-designed studies are needed to clarify the role of MTHFR polymorphisms to derive dose adjustment recommendations on the basis of the patient's genotype. JF - Pharmacogenomics AU - Toffoli, Giuseppe AU - De Mattia, Elena AD - Experimental and Clinical Pharmacology Unit, CRO National Cancer Institute via Franco Gallini, 2, 33081 Aviano (PN), Italy. gtoffoli@cro.it Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1195 EP - 1206 VL - 9 IS - 9 KW - Methylenetetrahydrofolate Reductase (NADPH2) KW - EC 1.5.1.20 KW - Index Medicus KW - Animals KW - Neoplasms -- enzymology KW - Risk Factors KW - Humans KW - Genetic Predisposition to Disease KW - Neoplasms -- genetics KW - Polymorphism, Genetic -- drug effects KW - Pharmacogenetics -- trends KW - Methylenetetrahydrofolate Reductase (NADPH2) -- metabolism KW - Polymorphism, Genetic -- genetics KW - Methylenetetrahydrofolate Reductase (NADPH2) -- antagonists & inhibitors KW - Pharmacogenetics -- methods KW - Methylenetetrahydrofolate Reductase (NADPH2) -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69535375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=Pharmacogenetic+relevance+of+MTHFR+polymorphisms.&rft.au=Toffoli%2C+Giuseppe%3BDe+Mattia%2C+Elena&rft.aulast=Toffoli&rft.aufirst=Giuseppe&rft.date=2008-09-01&rft.volume=9&rft.issue=9&rft.spage=1195&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=1744-8042&rft_id=info:doi/10.2217%2F14622416.9.9.1195 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-12 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2217/14622416.9.9.1195 ER - TY - JOUR T1 - Abnormalities in cortical and transcallosal inhibitory mechanisms in subjects at high risk for alcohol dependence: a TMS study. AN - 69533036; 18422835 AB - Central nervous system (CNS) hyperexcitability and a resulting state of behavioral undercontrol are thought to underlie the vulnerability to early-onset alcohol dependence (AD). The aim of this study was to explore the differences in the functioning of cortical inhibitory systems, utilizing transcranial magnetic stimulation (TMS), in subjects at high risk (HR) and low risk (LR) for AD and to examine the relationship between CNS inhibition and behavioral undercontrol. Right-handed HR (n = 15) and LR (n = 15) subjects, matched for age, gender, height, weight and education, were assessed for psychopathology and family history of alcoholism using the Semi-Structured Assessment for the Genetics of Alcoholism and the Family Interview for Genetic Studies. Following single-pulse TMS, an electromyogram recorded from the right opponens pollicis muscle was used to measure the silent periods at different stimulus intensities. HR subjects had significantly shorter contralateral and ipsilateral (iSP) silent periods and a relatively higher prevalence of 'absent' iSP. They had significantly higher mean externalizing symptoms scores (ESS) than LR subjects, and there was a significant negative correlation between iSP duration and ESS. These preliminary findings suggest that HR subjects have relative impairments in corticocortical and transcallosal inhibitory mechanisms. The consequent state of CNS hyperexcitability may be etiologically linked to the excess of externalizing behaviors observed in this population, which is thought to be a predisposition to a higher risk of developing early-onset alcoholism. JF - Addiction biology AU - Muralidharan, Kesavan AU - Venkatasubramanian, Ganesan AU - Pal, Pramod K AU - Benegal, Vivek AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 373 EP - 379 VL - 13 IS - 3-4 KW - Index Medicus KW - Young Adult KW - Risk Factors KW - Humans KW - Patient Acceptance of Health Care -- statistics & numerical data KW - Adult KW - Electromyography KW - Child KW - Adolescent KW - Male KW - Alcoholism -- epidemiology KW - Transcranial Magnetic Stimulation -- methods KW - Alcoholism -- therapy KW - Alcoholism -- physiopathology KW - Neural Inhibition -- physiology KW - Corpus Callosum -- physiopathology KW - Cerebral Cortex -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69533036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Abnormalities+in+cortical+and+transcallosal+inhibitory+mechanisms+in+subjects+at+high+risk+for+alcohol+dependence%3A+a+TMS+study.&rft.au=Muralidharan%2C+Kesavan%3BVenkatasubramanian%2C+Ganesan%3BPal%2C+Pramod+K%3BBenegal%2C+Vivek&rft.aulast=Muralidharan&rft.aufirst=Kesavan&rft.date=2008-09-01&rft.volume=13&rft.issue=3-4&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=1369-1600&rft_id=info:doi/10.1111%2Fj.1369-1600.2007.00093.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-05 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1369-1600.2007.00093.x ER - TY - JOUR T1 - Modulation of brain response to emotional images by alcohol cues in alcohol-dependent patients. AN - 69532401; 18507736 AB - Alcohol is often used to modulate mood states. Alcohol drinkers report that they use alcohol both to enhance positive affect and to reduce dysphoria, and alcohol-dependent patients specifically state reduction of negative affect as a primary reason for drinking. The current study proposes that alcohol cues may reduce negative affect in alcoholics. We used functional magnetic resonance imaging to examine brain activation in response to combination images that juxtaposed negative or positive International Affective Picture System (IAPS) images with an alcohol or non-alcohol-containing beverage. We found that in the absence of the alcohol cue, alcoholics showed more activation to negative than to positive images and greater activation than controls to negative images. When the IAPS images were presented with the alcohol cue, there was a decreased difference in activation between the positive and negative images among the alcoholics, and a decreased difference in response to the negative images between controls and alcoholics. Additionally, in the neutral-beverage conditions, anxiety ratings significantly predicted activation in the right parahippocampal gyrus but did not predict activation when the alcohol cues were presented. In conclusion, the alcohol cues may have modulated cortical networks involved in the processing of emotional stimuli by eliciting a conditioned response in the alcoholics, but not in the controls, which may have decreased responsiveness to the negative images. JF - Addiction biology AU - Gilman, Jodi M AU - Hommer, Daniel W AD - Section of Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, NIH, 10 Center Dr. (10CRC/15330), Bethesda, MD 20892-1108, USA. gilmanj@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 423 EP - 434 VL - 13 IS - 3-4 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Demography KW - Amygdala -- physiopathology KW - Humans KW - Adult KW - Cues KW - Arousal -- physiology KW - Male KW - Female KW - Brain -- physiopathology KW - Photic Stimulation KW - Alcoholism -- diagnosis KW - Brain -- anatomy & histology KW - Affect KW - Alcoholism -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69532401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Modulation+of+brain+response+to+emotional+images+by+alcohol+cues+in+alcohol-dependent+patients.&rft.au=Gilman%2C+Jodi+M%3BHommer%2C+Daniel+W&rft.aulast=Gilman&rft.aufirst=Jodi&rft.date=2008-09-01&rft.volume=13&rft.issue=3-4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=1369-1600&rft_id=info:doi/10.1111%2Fj.1369-1600.2008.00111.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-05 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1369-1600.2008.00111.x ER - TY - JOUR T1 - Dietary factors, food contamination and lung cancer risk in Xuanwei, China. AN - 69525127; 18304686 AB - In rural Xuanwei County, China, the high incidence of lung cancer is attributable largely to burning smoky coal indoors for heating and cooking without adequate ventilation. Such burning generates very high levels of indoor air pollutants, including carcinogenic polycyclic aromatic hydrocarbons, which could contaminate foodstuffs in the home. Thus, residents could be exposed to carcinogenic coal emissions not only via inhalation but also via ingestion of these foodstuffs. A population-based case-control study of 498 lung cancer patients and 498 controls was conducted from 1985 through 1990 in Xuanwei. The interviewer-administered study questionnaire queried the frequency of food items commonly consumed in this region. Overall and sex-specific multiple logistic regression models were constructed to estimate Odds ratios (OR) and 95% confidence intervals (CI) for consumption of these foods. Intake of rice, green vegetables, mushrooms and fresh meat was associated with an increased risk of lung cancer. In contrast, intake of corn, buckwheat, radishes, peppers, melons, pickled vegetables, and salt-preserved meats was associated with reduced risk. The detrimental effect of ingesting green vegetables (OR, 2.39; 95% CI, 1.28-4.48) is consistent with previous reports. These findings suggest that in Xuanwei, food contamination by environmental polycyclic aromatic hydrocarbons may be an important risk factor for lung cancer, and that differential contamination of foods by polycyclic aromatic hydrocarbons possibly explained the different associations with lung cancer risk. JF - Lung cancer (Amsterdam, Netherlands) AU - Shen, Min AU - Chapman, Robert S AU - He, Xingzhou AU - Liu, Larry Z AU - Lai, Hong AU - Chen, Wei AU - Lan, Qing AD - Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, United States. shenmi@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 275 EP - 282 VL - 61 IS - 3 SN - 0169-5002, 0169-5002 KW - Coal KW - 0 KW - Polycyclic Aromatic Hydrocarbons KW - Index Medicus KW - Rural Population KW - Logistic Models KW - Risk Factors KW - Humans KW - China -- epidemiology KW - Surveys and Questionnaires KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Male KW - Female KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Coal -- toxicity KW - Air Pollution, Indoor -- adverse effects KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- epidemiology KW - Food Contamination KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69525127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.atitle=Dietary+factors%2C+food+contamination+and+lung+cancer+risk+in+Xuanwei%2C+China.&rft.au=Shen%2C+Min%3BChapman%2C+Robert+S%3BHe%2C+Xingzhou%3BLiu%2C+Larry+Z%3BLai%2C+Hong%3BChen%2C+Wei%3BLan%2C+Qing&rft.aulast=Shen&rft.aufirst=Min&rft.date=2008-09-01&rft.volume=61&rft.issue=3&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.issn=01695002&rft_id=info:doi/10.1016%2Fj.lungcan.2007.12.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-08 N1 - Date created - 2008-09-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.lungcan.2007.12.024 ER - TY - JOUR T1 - Gender differences among hardcore smokers: an analysis of the tobacco use supplement of the current population survey. AN - 69521032; 18707532 AB - Despite significant declines in smoking rates in the United States, a substantial percentage of adults continue to smoke. Improved understanding of current smokers and their contact with sources of cessation support future tobacco control efforts. Recent evidence suggests that hardcore smokers, established smokers without a history of quit attempts, have less contact with cessation support. Although gender is among the major factors that influence smoking cessation, no research is available on gender differences among hardcore smokers. Demographic, environmental, and smoking-related characteristics of female hardcore smokers and male hardcore smokers and other female smokers were examined. Data from 17,777 smokers from the 2003 Current Population Survey Tobacco Use Supplement were analyzed. Compared with female hardcore smokers, male hardcore smokers were more likely to have contact with smoking restrictions at work (OR = 1.69) and at home (OR = 1.45). Compared with female hardcore smokers, female other smokers were more likely to have seen a healthcare provider during the past year who advised them to quit smoking (OR = 1.39) and more likely to have smoking restrictions at work (OR = 1.25) and at home (OR = 2.32)). Measures of nicotine dependence suggested that female hardcore smokers were less dependent than male hardcore smokers but more dependent than other female smokers. The sociodemographic and healthcare access variations in tobacco use identified in our analyses have significant public health implications and underscore the vital need for clinical and scientific advances in tobacco use prevention and control efforts. JF - Journal of women's health (2002) AU - Augustson, Erik M AU - Barzani, Dilyara AU - Rutten, Lila J Finney AU - Marcus, Stephen AD - Tobacco Control Research Branch, National Cancer Institute, Bethesda, Maryland 20892-7337, USA. augustse@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1167 EP - 1173 VL - 17 IS - 7 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Humans KW - Socioeconomic Factors KW - Logistic Models KW - Patient Acceptance of Health Care KW - Adult KW - Health Surveys KW - Tobacco KW - Middle Aged KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Male KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- psychology KW - Tobacco Use Disorder -- prevention & control KW - Smoking -- psychology KW - Smoking -- prevention & control KW - Smoking -- epidemiology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69521032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+women%27s+health+%282002%29&rft.atitle=Gender+differences+among+hardcore+smokers%3A+an+analysis+of+the+tobacco+use+supplement+of+the+current+population+survey.&rft.au=Augustson%2C+Erik+M%3BBarzani%2C+Dilyara%3BRutten%2C+Lila+J+Finney%3BMarcus%2C+Stephen&rft.aulast=Augustson&rft.aufirst=Erik&rft.date=2008-09-01&rft.volume=17&rft.issue=7&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Journal+of+women%27s+health+%282002%29&rft.issn=1931-843X&rft_id=info:doi/10.1089%2Fjwh.2007.0535 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 2000 Mar;90(3):387-94 [10705856] Am J Epidemiol. 2000 Aug 1;152(3):219-25 [10933268] JAMA. 2000 Aug 9;284(6):717-22 [10927780] Nicotine Tob Res. 1999 Jun;1(2):153-62 [11072396] Cochrane Database Syst Rev. 2001;(2):CD000165 [11405953] Am J Prev Med. 2002 May;22(4):234-9 [11988379] MMWR Morb Mortal Wkly Rep. 2002 Apr 12;51(14):300-3 [12002168] Am J Public Health. 2002 Jun;92(6):990-6 [12036794] Oncogene. 2002 Oct 21;21(48):7326-40 [12379876] Nicotine Tob Res. 2003 Feb;5(1):111-6 [12745512] BMJ. 2003 May 17;326(7398):1061 [12750206] Am J Public Health. 2004 Feb;94(2):211-7 [14759929] Nicotine Tob Res. 2004 Apr;6(2):327-48 [15203807] BMJ. 2004 Jun 26;328(7455):1519 [15213107] Nicotine Tob Res. 2004 Aug;6(4):621-9 [15370158] JAMA. 1988 May 20;259(19):2883-9 [3367456] Am J Prev Med. 1990 Sep-Oct;6(5):251-7 [2268453] J Clin Epidemiol. 1991;44(11):1247-53 [1941018] Am J Public Health. 1994 Jul;84(7):1127-31 [8017537] Health Psychol. 1994 May;13(3):278-81 [8055863] Am J Public Health. 1995 Feb;85(2):223-30 [7856782] Acta Paediatr. 1996 Feb;85(2):213-9 [8640053] Am J Prev Med. 1997 May-Jun;13(3):159-66 [9181202] Addict Behav. 1997 Jul-Aug;22(4):521-33 [9290861] J Clin Psychol. 1998 Feb;54(2):223-35 [9467767] Exp Clin Psychopharmacol. 1999 May;7(2):135-44 [10340153] Prev Med. 1999 Jul;29(1):57-62 [10419801] Drug Alcohol Depend. 2005 Jul;79(1):45-52 [15943943] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1077-80 [17548666] Tob Control. 1999 Autumn;8(3):261-5 [10599569] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/jwh.2007.0535 ER - TY - JOUR T1 - Oxidants and the pathogenesis of lung diseases. AN - 69519884; 18774381 AB - The increasing number of population-based and epidemiologic associations between oxidant pollutant exposures and cardiopulmonary disease exacerbation, decrements in pulmonary function, and mortality underscores the important detrimental effects of oxidants on public health. Because inhaled oxidants initiate a number of pathologic processes, including inflammation of the airways, which may contribute to the pathogenesis and/or exacerbation of airways disease, it is critical to understand the mechanisms through which exogenous and endogenous oxidants interact with molecules in the cells, tissues, and epithelial lining fluid of the lung. Furthermore, it is clear that interindividual variation in response to a given exposure also exists across an individual lifetime. Because of the potential impact that oxidant exposures may have on reproductive outcomes and infant, child, and adult health, identification of the intrinsic and extrinsic factors that may influence susceptibility to oxidants remains an important issue. In this review, we discuss mechanisms of oxidant stress in the lung, the role of oxidants in lung disease pathogenesis and exacerbation (eg, asthma, chronic obstructive pulmonary disease, and acute respiratory distress syndrome), and the potential risk factors (eg, age, genetics) for enhanced susceptibility to oxidant-induced disease. JF - The Journal of allergy and clinical immunology AU - Ciencewicki, Jonathan AU - Trivedi, Shweta AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 456 EP - 68; quiz 469-70 VL - 122 IS - 3 KW - Air Pollutants KW - 0 KW - Allergens KW - Oxidants KW - Reactive Oxygen Species KW - Transcription Factors KW - Ozone KW - 66H7ZZK23N KW - Protein Kinases KW - EC 2.7.- KW - Abridged Index Medicus KW - Index Medicus KW - Protein Kinases -- metabolism KW - Animals KW - Age Factors KW - Transcription Factors -- metabolism KW - Risk Factors KW - Humans KW - Oxidative Stress KW - Lung -- drug effects KW - Lung -- metabolism KW - Ozone -- metabolism KW - Hypersensitivity -- epidemiology KW - Reactive Oxygen Species -- metabolism KW - Lung Diseases -- etiology KW - Lung Diseases -- genetics KW - Hypersensitivity -- etiology KW - Oxidants -- toxicity KW - Lung Diseases -- epidemiology KW - Oxidants -- metabolism KW - Hypersensitivity -- genetics KW - Reactive Oxygen Species -- toxicity KW - Air Pollutants -- toxicity KW - Ozone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69519884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Oxidants+and+the+pathogenesis+of+lung+diseases.&rft.au=Ciencewicki%2C+Jonathan%3BTrivedi%2C+Shweta%3BKleeberger%2C+Steven+R&rft.aulast=Ciencewicki&rft.aufirst=Jonathan&rft.date=2008-09-01&rft.volume=122&rft.issue=3&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2008.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-01 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 1999 Dec;160(6):1934-42 [10588609] Am J Epidemiol. 2000 Jan 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[12532099] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jaci.2008.08.004 ER - TY - JOUR T1 - Function, mechanism and evolution of the moubatin-clade of soft tick lipocalins. AN - 69519443; 18694828 AB - The "moubatin-clade" of soft tick lipocalins, although monophyletic, shows clear signs of paralogy as indicated by the various functions associated with this protein family. This includes anti-platelet (moubatin), anti-complement (OMCI) and toxic (TSGP2) activities in the vertebrate host. In order to understand the evolution of function and how it relates to the various paralogs in this clade, we characterized a number of different proteins in regard to undefined function and mechanism. By utilizing gain-of-function for TSGP2 and loss-of-function for TSGP3, we show that inhibition of collagen-induced platelet aggregation by moubatin and TSGP3 is due to scavenging of thromboxane A2. Moubatin, TSGP2 and TSGP3 are also able to bind leukotriene B4 with high affinity. TSGP2 and TSGP3, but not moubatin, binds complement C5, with kinetics that indicates that conformation change occurs during interaction. A conserved loop and histidine residue in the sequences of OMCI, TSGP2 and TSGP3 are implicated in the interaction with complement C5. The data presented suggest that the ancestral function evolved in this clade was aimed at inhibition of vasoconstriction, platelet aggregation and neutrophil aggregation, primarily by scavenging of thromboxane A2 and leukotriene B4. C5 complement targeting activity evolved within this clade, probably within the Old World Ornithodorinae. The moubatin-clade itself most probably derived from the related histamine and serotonin-binding lipocalin sub-family that is conserved within the Argasidae. JF - Insect biochemistry and molecular biology AU - Mans, Ben J AU - Ribeiro, José M C AD - Laboratory for Malaria and Vector Research, National Institutes of Health, Rockville, MD 20852, USA. mansb@arc.agric.za Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 841 EP - 852 VL - 38 IS - 9 SN - 0965-1748, 0965-1748 KW - Arthropod Proteins KW - 0 KW - Carrier Proteins KW - Complement C5 KW - Insect Proteins KW - Leukotrienes KW - Lipocalins KW - OmCI protein, tick KW - Platelet Aggregation Inhibitors KW - Proteins KW - Recombinant Proteins KW - moubatin KW - Thromboxane A2 KW - 57576-52-0 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Phylogeny KW - Animals KW - Complement C5 -- metabolism KW - Collagen -- metabolism KW - Amino Acid Sequence KW - Platelet Aggregation Inhibitors -- metabolism KW - Leukotrienes -- metabolism KW - Binding Sites KW - Rats KW - Platelet Aggregation KW - Thromboxane A2 -- metabolism KW - Sequence Alignment KW - Recombinant Proteins -- metabolism KW - In Vitro Techniques KW - Molecular Sequence Data KW - Protein Interaction Domains and Motifs KW - Argasidae -- metabolism KW - Insect Proteins -- genetics KW - Argasidae -- genetics KW - Lipocalins -- genetics KW - Proteins -- metabolism KW - Proteins -- genetics KW - Lipocalins -- metabolism KW - Evolution, Molecular KW - Insect Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69519443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Insect+biochemistry+and+molecular+biology&rft.atitle=Function%2C+mechanism+and+evolution+of+the+moubatin-clade+of+soft+tick+lipocalins.&rft.au=Mans%2C+Ben+J%3BRibeiro%2C+Jos%C3%A9+M+C&rft.aulast=Mans&rft.aufirst=Ben&rft.date=2008-09-01&rft.volume=38&rft.issue=9&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Insect+biochemistry+and+molecular+biology&rft.issn=09651748&rft_id=info:doi/10.1016%2Fj.ibmb.2008.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Jun 23;275(25):18717-23 [10749868] Mol Biol Evol. 2003 Jul;20(7):1158-67 [12777525] Biochim Biophys Acta. 2000 Oct 18;1482(1-2):337-50 [11058774] Electrophoresis. 2001 May;22(9):1739-46 [11425229] Bioinformatics. 2001 Dec;17(12):1244-5 [11751241] Insect Mol Biol. 2002 Feb;11(1):79-86 [11841505] Toxicon. 2002 Jul;40(7):1007-16 [12076655] Mol Biol Evol. 2002 Oct;19(10):1695-705 [12270896] Annu Rev Entomol. 2003;48:73-88 [12194906] Insect Biochem Mol Biol. 2004 Jan;34(1):1-17 [14723893] Insect Biochem Mol Biol. 2004 Jun;34(6):585-94 [15147759] Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H419-24 [15016629] Br J Pharmacol. 1981 Jul;73(3):773-8 [7248665] Annu Rev Pharmacol Toxicol. 1987;27:301-13 [3034139] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] J Biol Chem. 1993 Mar 15;268(8):5445-9 [8449906] J Biol Chem. 1993 Mar 15;268(8):5450-6 [8449907] J Parasitol. 1993 Dec;79(6):834-42 [8277375] Infect Agents Dis. 1995 Sep;4(3):143-52 [8548192] Trends Biochem Sci. 1998 Oct;23(10):403-5 [9810230] Mol Cell. 1999 May;3(5):661-71 [10360182] Insect Biochem Mol Biol. 2004 Nov;34(11):1187-93 [15522614] Arch Insect Biochem Physiol. 2005 Feb;58(2):97-105 [15660358] J Immunol. 2005 Feb 15;174(4):2084-91 [15699138] J Allergy Clin Immunol. 2005 Mar;115(3):617-22 [15753913] Curr Opin Investig Drugs. 2005 Nov;6(11):1131-5 [16312134] J Biol Chem. 2006 Jan 27;281(4):1935-42 [16301315] Insect Biochem Mol Biol. 2006 Feb;36(2):111-29 [16431279] Curr Top Med Chem. 2007;7(3):311-40 [17305573] J Biol Chem. 2007 Mar 16;282(11):8292-9 [17215252] Insect Mol Biol. 2007 Apr;16(2):155-66 [17298559] Prostaglandins Other Lipid Mediat. 2007 May;83(3):209-12 [17481557] J Mol Biol. 2007 Jun 8;369(3):784-93 [17445829] Insect Biochem Mol Biol. 2007 Nov;37(11):1149-59 [17916501] Insect Biochem Mol Biol. 2008 Jan;38(1):1-21 [18070662] Insect Biochem Mol Biol. 2008 Jan;38(1):22-41 [18070663] Insect Biochem Mol Biol. 2008 Jan;38(1):42-58 [18070664] J Biol Chem. 2008 Jul 4;283(27):18721-33 [18445596] Insect Biochem Mol Biol. 2008 Sep;38(9):862-70 [18675910] Biochim Biophys Acta. 2000 Oct 18;1482(1-2):9-24 [11058743] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ibmb.2008.06.007 ER - TY - JOUR T1 - The impact of opiate agonist maintenance therapy on drug use within social networks of injecting drug users. AN - 69513785; 18770085 AB - This study examined whether participation in opiate drug treatment is associated with changes in drug use and injecting drug use within the social networks of injecting drug users. Participants were 245 injecting drug users who attended the Baltimore Needle Exchange Program during 2002-2004 and requested treatment and received a referral for opiate agonist treatment as part of an intervention to improve treatment outcomes. Data included interviews at baseline, 3, 6, 12, and 18 months and drug treatment program agency records. The mean age of participants was 42.2 years; 77% were African American, 69% were male, and 48% entered treatment. Final generalized estimating equations (GEE) models indicated that participants that entered opiate drug treatment exhibited approximately a 20% decrease in the proportional odds of having friends that used drugs (p = 0.04). Additionally, participants that entered opiate drug treatment exhibited a 26% decrease in the proportional odds of having friends that injected drugs (p = 0.01). These findings contribute evidence to further understand the dynamics between opiate drug treatment, changes in social network risk, and treatment outcomes, as well as suggest an important role for peer-based interventions to support entry and retention in opiate drug treatment. JF - The American journal on addictions AU - Lloyd, Jacqueline J AU - Strathdee, Steffanie A AU - Pu, Minya AU - Havens, Jennifer R AU - Cornelius, Llewellyn J AU - Huettner, Steven AU - Latkin, Carl A AD - Temple University School of Social Administration, Philadelphia, Pennsylvania, USA. lloydj2@nida.nih.gov PY - 2008 SP - 414 EP - 421 VL - 17 IS - 5 KW - Narcotic Antagonists KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Humans KW - Adult KW - Treatment Outcome KW - Surveys and Questionnaires KW - Male KW - Female KW - Methadone -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Substance Abuse, Intravenous -- rehabilitation KW - Needle-Exchange Programs -- statistics & numerical data KW - Substance Abuse, Intravenous -- epidemiology KW - Social Support UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69513785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=The+impact+of+opiate+agonist+maintenance+therapy+on+drug+use+within+social+networks+of+injecting+drug+users.&rft.au=Lloyd%2C+Jacqueline+J%3BStrathdee%2C+Steffanie+A%3BPu%2C+Minya%3BHavens%2C+Jennifer+R%3BCornelius%2C+Llewellyn+J%3BHuettner%2C+Steven%3BLatkin%2C+Carl+A&rft.aulast=Lloyd&rft.aufirst=Jacqueline&rft.date=2008-09-01&rft.volume=17&rft.issue=5&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=1521-0391&rft_id=info:doi/10.1080%2F10550490802268165 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-04 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10550490802268165 ER - TY - CONF T1 - Linking tobacco control policies and practices to early cancer endpoints: surveillance as an agent for change. AN - 69500199; 18768485 AB - State tobacco control programs provide an important laboratory for the development, implementation, and evaluation of comprehensive tobacco control interventions. Studies have shown that states and municipalities with aggressive tobacco control programs have experienced more rapid decreases in per capita cigarette sales, smoking prevalence, lung cancer, and heart disease than entities without such programs. Despite strong evidence that population-level interventions are critical in achieving large and sustained reductions in tobacco use, states do not fund tobacco control efforts at levels recommended by the Centers for Disease Control and Prevention. Research on the effectiveness and cost effectiveness of these activities is essential to inform and strengthen tobacco control at the state level. A workshop, co-organized by the American Cancer Society, the National Cancer Institute, the American Association for Cancer Research, and the Centers for Disease Control and Prevention, was held in Philadelphia in December, 2007, to discuss the topic "Linking tobacco control policies and practices to early cancer endpoints: surveillance as an agent for change." Participants represented three different disciplines. Tobacco surveillance researchers described the data currently collected on state-level tobacco control policies, protobacco countermeasures by the industry, public attitudes toward tobacco use, and measures of smoking prevalence and consumption. Cancer registry experts described the geographic coverage of high quality, population-based cancer registries. Mathematical modeling experts discussed various modeling approaches that can be used to relate upstream tobacco promotion and control activities to downstream measures such as public attitudes, changes in tobacco use, and trends in tobacco-related diseases. The most important recommendation of the Workshop was a call for national leadership to enhance the collection and integration of data from multiple sources as a resource to further study and strengthen the scientific basis for tobacco control. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Hartman, Anne M AU - Thun, Michael J AU - Ballard-Barbash, Rachel AU - Organizing Committee Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 2215 EP - 2219 VL - 17 IS - 9 KW - Index Medicus KW - Registries KW - Health Promotion -- methods KW - Endpoint Determination KW - Humans KW - Tobacco Industry KW - Health Policy KW - United States -- epidemiology KW - Population Surveillance KW - Tobacco Use Disorder -- epidemiology KW - Neoplasms -- epidemiology KW - Tobacco Use Disorder -- prevention & control KW - Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69500199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Linking+tobacco+control+policies+and+practices+to+early+cancer+endpoints%3A+surveillance+as+an+agent+for+change.&rft.au=Hartman%2C+Anne+M%3BThun%2C+Michael+J%3BBallard-Barbash%2C+Rachel%3BOrganizing+Committee&rft.aulast=Hartman&rft.aufirst=Anne&rft.date=2008-09-01&rft.volume=17&rft.issue=9&rft.spage=2215&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0563 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-09-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1171-81 [15894668] Pediatrics. 2005 Dec;116(6):1516-28 [16322180] Am J Public Health. 2006 Mar;96(3):494-8 [16449585] Tob Control. 2007 Apr;16(2):85-90 [17400944] Am J Prev Med. 2007 Dec;33(6 Suppl):S318-26 [18021906] J Natl Cancer Inst. 2003 Nov 19;95(22):1681-91 [14625259] Prev Chronic Dis. 2008 Apr;5(2):A63 [18341798] J Natl Cancer Inst. 2008 Dec 3;100(23):1672-94 [19033571] Prev Med. 2009 Jan;48(1 Suppl):S4-10 [18809429] Tob Control. 2001 Dec;10(4):337-9 [11740024] Cancer Causes Control. 2003 Aug;14(6):579-85 [12948289] Am J Public Health. 2008 Feb;98(2):304-9 [18172148] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0563 ER - TY - JOUR T1 - Ex vivo dynamic imaging of retinal microglia using time-lapse confocal microscopy. AN - 69498426; 18487378 AB - Retinal microglia have been implicated in the pathogenesis of various retinal diseases, but their basic function and cellular phenotype remain incompletely understood. Here, the authors used a novel ex vivo retinal imaging preparation to examine the behavioral phenotype of living retinal microglia in intact tissue and in response to injury. Fluorescence-labeled microglia in retinal explants from CX3CR1(+/GFP) transgenic mice were observed using time-lapse confocal imaging. High spatial and temporal resolution imaging parameters were used to follow dynamic microglial behavior in real time. Under normal conditions, resting retinal microglia are not static in structure but instead exhibit extensive structural dynamism in their cellular processes. Process movements are highly random in direction but are balanced to maintain overall cellular symmetry and arbor size. At rest, however, these exuberant process movements do not result in overt cellular migration. After focal laser injury, microglial processes increase significantly in their motility and direct themselves toward the injury site. Microglia rapidly transition their morphologies from symmetric to polarized toward the laser lesion. Microglia also transition from a fixed to a migratory phenotype, translocating through tissue while retaining their ramified morphology. Retinal microglia normally occupying uninjured tissue display a continuous, dynamic behavior that suggests functions of tissue surveillance and intercellular communication. Microglial behavior is highly regulated by, and immediately responsive to, focal tissue injury and may constitute a therapeutic cellular response to focal laser photocoagulation. Ex vivo live imaging in the retina is an experimental approach well suited to the study of dynamic aspects of microglial physiology. JF - Investigative ophthalmology & visual science AU - Lee, Jung Eun AU - Liang, Katharine J AU - Fariss, Robert N AU - Wong, Wai T AD - Office of the Scientific Director, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 4169 EP - 4176 VL - 49 IS - 9 KW - CX3CR1 protein, human KW - 0 KW - Receptors, Chemokine KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Argon KW - 67XQY1V3KH KW - Index Medicus KW - Animals KW - Humans KW - Argon -- toxicity KW - Mice, Inbred C57BL KW - Crosses, Genetic KW - Receptors, Chemokine -- genetics KW - Mice KW - Mice, Transgenic KW - Time Factors KW - Lasers -- adverse effects KW - Green Fluorescent Proteins -- genetics KW - Retina -- cytology KW - Microglia -- cytology KW - Microglia -- radiation effects KW - Microscopy, Confocal -- methods KW - Retina -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69498426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Ex+vivo+dynamic+imaging+of+retinal+microglia+using+time-lapse+confocal+microscopy.&rft.au=Lee%2C+Jung+Eun%3BLiang%2C+Katharine+J%3BFariss%2C+Robert+N%3BWong%2C+Wai+T&rft.aulast=Lee&rft.aufirst=Jung&rft.date=2008-09-01&rft.volume=49&rft.issue=9&rft.spage=4169&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=1552-5783&rft_id=info:doi/10.1167%2Fiovs.08-2076 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-06 N1 - Date created - 2008-09-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Jul 1;20(13):5024-36 [10864960] Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3649-58 [18316698] Ocul Immunol Inflamm. 2002 Mar;10(1):27-39 [12461701] Exp Eye Res. 2003 Apr;76(4):463-71 [12634111] Invest Ophthalmol Vis Sci. 2004 Mar;45(3):971-6 [14985319] Curr Drug Targets. 2004 Oct;5(7):619-27 [15473251] Ophthalmology. 1991 May;98(5 Suppl):766-85 [2062512] Nature. 1995 Apr 20;374(6524):716-8 [7715725] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] J Neurosci. 1998 Nov 1;18(21):8839-52 [9786990] Arch Ophthalmol. 1999 Aug;117(8):1050-6 [10448748] Nat Neurosci. 2005 Jun;8(6):752-8 [15895084] Science. 2005 May 27;308(5726):1314-8 [15831717] Mol Vis. 2005;11:491-500 [16052164] J Neurosci Res. 2005 Aug 1;81(3):314-21 [15929071] J Neurosci Res. 2005 Aug 1;81(3):302-13 [15954124] Vision Res. 2006 Apr;46(8-9):1336-45 [16289196] Nat Neurosci. 2006 Jul;9(7):917-24 [16732273] Kidney Int. 2006 Aug;70(3):591-6 [16760907] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Vision Res. 2007 Mar;47(5):612-23 [17267004] Glia. 2007 Jun;55(8):873-84 [17405148] J Leukoc Biol. 2007 Jun;81(6):1345-51 [17405851] Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3827-36 [17652758] Science. 2007 Aug 3;317(5838):666-70 [17673663] J Clin Invest. 2007 Oct;117(10):2920-8 [17909628] Nat Neurosci. 2007 Nov;10(11):1387-94 [17965659] J Comp Neurol. 2008 Jan 10;506(2):224-39 [18022954] J Neuroimmune Pharmacol. 2006 Jun;1(2):127-37 [18040779] Arch Ophthalmol. 2008 Feb;126(2):227-32 [18268214] Glia. 2001 Mar 1;33(3):256-66 [11241743] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1167/iovs.08-2076 ER - TY - JOUR T1 - Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide. AN - 69493465; 18712839 AB - Dimethyl sulfoxide (DMSO) is commonly used in biological studies to dissolve drugs and enzyme inhibitors with low solubility. Although DMSO is generally thought of as being relatively inert, it can induce biological effects that are often overlooked. An example that highlights this potential problem is found in a recent report demonstrating a pathogenic role for natural killer T (NKT) and natural killer (NK) cells in acetaminophen-induced liver injury (AILI) in C57Bl/6 mice in which DMSO was used to facilitate acetaminophen (APAP) dissolution. We report that NKT and NK cells do not play a pathologic role in AILI in C57Bl/6 mice in the absence of DMSO. Although AILI was significantly attenuated in mice depleted of NKT and NK cells prior to APAP treatment in the presence of DMSO, no such effect was observed when APAP was dissolved in saline. Because of this unexpected finding, the effects of DMSO on hepatic NKT and NK cells were subsequently investigated. When given alone, DMSO activated hepatic NKT and NK cells in vivo as evidenced by increased NKT cell numbers and higher intracellular levels of the cytotoxic effector molecules interferon-gamma (IFN-gamma) and granzyme B in both cell types. Similarly, when used as a solvent for APAP, DMSO again increased NKT cell numbers and induced IFN-gamma and granzyme B expression in both cell types. These data demonstrate a previously unappreciated effect of DMSO on hepatic NKT and NK cells, suggesting that DMSO should be used cautiously in experiments involving these cells. JF - Hepatology (Baltimore, Md.) AU - Masson, Mary Jane AU - Carpenter, Leah D AU - Graf, Mary L AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 889 EP - 897 VL - 48 IS - 3 KW - Analgesics, Non-Narcotic KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Interferon-gamma KW - 82115-62-6 KW - Granzymes KW - EC 3.4.21.- KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Apoptosis -- drug effects KW - Mice, Inbred C57BL KW - Interferon-gamma -- metabolism KW - Disease Models, Animal KW - Cell Culture Techniques -- methods KW - Mice KW - Male KW - Female KW - Granzymes -- metabolism KW - Dimethyl Sulfoxide -- pharmacology KW - Liver Diseases -- physiopathology KW - T-Lymphocyte Subsets -- physiology KW - Analgesics, Non-Narcotic -- pharmacology KW - Chemical and Drug Induced Liver Injury KW - Acetaminophen -- adverse effects KW - Killer Cells, Natural -- drug effects KW - Acetaminophen -- pharmacology KW - Analgesics, Non-Narcotic -- adverse effects KW - T-Lymphocyte Subsets -- drug effects KW - Liver Diseases -- pathology KW - Dimethyl Sulfoxide -- adverse effects KW - Killer Cells, Natural -- physiology KW - T-Lymphocyte Subsets -- pathology KW - Killer Cells, Natural -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69493465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Pathogenic+role+of+natural+killer+T+and+natural+killer+cells+in+acetaminophen-induced+liver+injury+in+mice+is+dependent+on+the+presence+of+dimethyl+sulfoxide.&rft.au=Masson%2C+Mary+Jane%3BCarpenter%2C+Leah+D%3BGraf%2C+Mary+L%3BPohl%2C+Lance+R&rft.aulast=Masson&rft.aufirst=Mary&rft.date=2008-09-01&rft.volume=48&rft.issue=3&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.22400 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-23 N1 - Date created - 2008-09-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2003 Sep 1;191(2):118-29 [12946648] J Immunol. 2003 Sep 15;171(6):2960-9 [12960320] Hepatology. 2004 Aug;40(2):434-41 [15368448] Ann N Y Acad Sci. 1975 Jan 27;243:308-10 [1055550] Ann N Y Acad Sci. 1975 Jan 27;243:73-80 [1055567] Ann N Y Acad Sci. 1975 Jan 27;243:81-90 [1055568] J Exp Med. 2000 Jan 3;191(1):105-14 [10620609] J Exp Med. 2000 Feb 21;191(4):661-8 [10684858] Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2731-6 [10694580] Am J Pathol. 2000 Apr;156(4):1245-52 [10751350] Proc Natl Acad Sci U S A. 2000 May 9;97(10):5498-503 [10792025] Eur J Immunol. 2000 Jul;30(7):1919-28 [10940881] Science. 2002 Apr 19;296(5567):553-5 [11968185] Immunity. 2002 Apr;16(4):583-94 [11970881] Hepatology. 2002 May;35(5):1093-103 [11981759] Biochem Biophys Res Commun. 2002 Jun 7;294(2):225-30 [12051698] FASEB J. 2002 Aug;16(10):1227-36 [12153990] Chem Res Toxicol. 2002 Dec;15(12):1504-13 [12482232] J Immunol. 2003 Feb 1;170(3):1197-201 [12538676] Biochem Pharmacol. 1987 Apr 15;36(8):1193-6 [3593409] Int J Immunopharmacol. 1987;9(7):769-73 [2962952] J Natl Cancer Inst. 1988 Apr 20;80(4):263-9 [3127594] Toxicology. 1988 Nov 14;52(1-2):165-75 [3188030] Drug Metabol Drug Interact. 1988;6(3-4):413-24 [3271647] J Exp Med. 1992 Feb 1;175(2):553-66 [1732416] J Leukoc Biol. 1994 Feb;55(2):221-6 [7507967] Hepatology. 1995 Apr;21(4):1045-50 [7705777] JAMA. 1997 Jan 22-29;277(4):301-6 [9002492] Toxicol Appl Pharmacol. 1997 Mar;143(1):1-12 [9073586] Immunity. 1998 Sep;9(3):345-53 [9768754] Gastroenterology. 2004 Dec;127(6):1760-74 [15578514] Curr Opin Drug Discov Devel. 2005 Jan;8(1):38-43 [15679170] Immunology. 2005 Mar;114(3):336-45 [15720435] Toxicol Sci. 2006 Jan;89(1):31-41 [16177235] Life Sci. 2006 Mar 6;78(15):1670-6 [16226279] Eur J Immunol. 2006 Apr;36(4):1028-38 [16552707] Hepatology. 2006 Jun;43(6):1220-30 [16729305] Hepatology. 2006 Jun;43(6):1191-4 [16729330] Gastroenterology. 2006 Jul;131(1):165-78 [16831600] Expert Opin Drug Metab Toxicol. 2006 Aug;2(4):493-503 [16859400] Hepatology. 2006 Dec;44(6):1421-31 [17133481] Drug Saf. 2007;30(4):277-94 [17408305] Chem Res Toxicol. 2007 May;20(5):734-44 [17439248] J Clin Invest. 2007 Aug;117(8):2302-12 [17641782] Clin Liver Dis. 2007 Aug;11(3):459-75, v [17723915] Clin Liver Dis. 2007 Aug;11(3):525-48, vi [17723918] Can J Microbiol. 2007 Dec;53(12):1330-47 [18059566] Comment In: Hepatology. 2008 Sep;48(3):699-701 [18752320] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/hep.22400 ER - TY - JOUR T1 - Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes. AN - 69492625; 18399919 AB - In this study we report the phototoxicity toward HaCaT keratinocytes that results from the photogeneration of superoxide and singlet oxygen ((1)O(2)) by four different "water-soluble" fullerene (C(60)) preparations-monomeric (gamma-CyD)(2)/C(60) (gamma-cyclodextrin bicapped C(60)) and three aggregated forms-THF/nC(60) (prepared by solvent exchange from THF solution); Son/nC(60) (prepared by sonication of a toluene/water mixture); and gamma-CyD/nC(60) (prepared by heating the [gamma-CyD](2)/C(60) aqueous solution). Our results demonstrate that all four C(60) preparations photogenerate (1)O(2) efficiently. However, the properties of C(60)-generated (1)O(2), including its availability for reactions in solution, are markedly different for the monomeric and aggregated forms. (1)O(2) produced by monomeric (gamma-CyD)(2)/C(60) is quenchable by NaN(3) and its quantum yield in D(2)O, which is only weakly dependent on oxygen concentration, is as high as C(60) in toluene. In contrast, (1)O(2) generated from aggregated C(60) is not quenchable by NaN(3), exhibits a solvent-independent short-lived lifetime (ca 2.9 micros), is highly sensitive to oxygen concentration while its phosphorescence is redshifted. All these features indicate that (1)O(2) is sequestered inside the C(60) aggregates, which may explain why these preparations were not phototoxic toward HaCaT cells. Electron paramagnetic resonance studies demonstrated the generation of the C(60) anion radical (C(60)) when (gamma-CyD)(2)/C(60) was irradiated (lambda > 300 nm) in the presence of a reducing agent (NADH); spin trapping experiments (lambda > 400 nm) with 5,5-dimethyl-1-pyrroline N-oxide clearly showed the generation of superoxide resulting from the reaction of C(60) with oxygen. In vitro tests with HaCaT keratinocytes provided evidence that (gamma-CyD)(2)/C(60) phototoxicity is mainly mediated by (1)O(2) (Type II mechanism) with only a minor contribution from free radicals (Type I mechanism). JF - Photochemistry and photobiology AU - Zhao, Baozhong AU - Bilski, Piotr J AU - He, Yu-Ying AU - Feng, Li AU - Chignell, Colin F AD - Laboratory of Pharmacology and Chemistry, NIEHS/NIH, Research Triangle Park, NC, USA. zhaob2@niehs.nih.gov PY - 2008 SP - 1215 EP - 1223 VL - 84 IS - 5 SN - 0031-8655, 0031-8655 KW - Fullerenes KW - 0 KW - Reactive Oxygen Species KW - Water KW - 059QF0KO0R KW - fullerene C60 KW - NP9U26B839 KW - Index Medicus KW - Photochemistry KW - Ultraviolet Rays KW - Solubility KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Cell Survival -- radiation effects KW - Time Factors KW - Keratinocytes -- radiation effects KW - Fullerenes -- pharmacology KW - Reactive Oxygen Species -- chemical synthesis KW - Fullerenes -- chemistry KW - Keratinocytes -- drug effects KW - Water -- chemistry KW - Reactive Oxygen Species -- toxicity KW - Fullerenes -- toxicity KW - Reactive Oxygen Species -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69492625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Photo-induced+reactive+oxygen+species+generation+by+different+water-soluble+fullerenes+%28C%29+and+their+cytotoxicity+in+human+keratinocytes.&rft.au=Zhao%2C+Baozhong%3BBilski%2C+Piotr+J%3BHe%2C+Yu-Ying%3BFeng%2C+Li%3BChignell%2C+Colin+F&rft.aulast=Zhao&rft.aufirst=Baozhong&rft.date=2008-09-01&rft.volume=84&rft.issue=5&rft.spage=1215&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/10.1111%2Fj.1751-1097.2008.00333.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-05 N1 - Date created - 2008-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1751-1097.2008.00333.x ER - TY - JOUR T1 - Nitric oxide is a key component in inflammation-accelerated tumorigenesis. AN - 69488281; 18757428 AB - Nitric oxide (NO(*)), an important signaling molecule and a component of inflammatory response, is involved in tumorigenesis. However, the quantity of NO(*) and the cellular microenvironment influences the role of NO(*) in tumor development. We used a genetic strategy to test the hypothesis that an inflammatory microenvironment with an enhanced level of NO(*) accelerates spontaneous tumor development. C. parvum-induced inflammation and increased NO(*) synthase-2 (NOS2) expression coincided with accelerated spontaneous tumor development, mostly lymphomas, in p53-/-NOS2+/+ C57BL6 mice when compared with the controls (P = 0.001). However, p53-/-NOS2-/- mice did not show any difference in tumor latency between C. parvum-treated and control groups. In C. parvum-treated p53-/-NOS2+/+ mice, tumor development was preceded by a higher expression of NOS2 and phosphorylated Akt-Ser(473) (pAkt-Ser473) in spleen, increased cell proliferation measured by Ki-67 IHC in spleen and thymus, and a lower apoptotic index and CD95-L expression in spleen and thymus. C. parvum-treated p53-/-NOS2+/+ mice showed an increase in the number of Foxp3(+) T-reg cells, dendritic cells (DC), as well as increased CD80(+), CD86(+), CD40(+), and CD83(+) on DC in the spleen. Regulatory T-cells (T-reg) and the maturation of DC may modulate tumorigenesis. An increase in the FoxP3(+)T-reg cells in C. parvum-treated p53-/-NOS2+/+ mice indicates a role of NO(*) in the regulation of T-reg cells that may contribute to a protumor shift of the immune environment favoring an accelerated tumor development. These data provide genetic and mechanistic evidence that an inflammatory microenvironment and an increased level of NO(*) can accelerate tumor development. JF - Cancer research AU - Hussain, S Perwez AU - He, Peijun AU - Subleski, Jeffery AU - Hofseth, Lorne J AU - Trivers, Glenwood E AU - Mechanic, Leah AU - Hofseth, Anne B AU - Bernard, Mark AU - Schwank, Jonathan AU - Nguyen, Giang AU - Mathe, Ewy AU - Djurickovic, Draginja AU - Haines, Diana AU - Weiss, Jonathan AU - Back, Timothy AU - Gruys, Eilene AU - Laubach, Victor E AU - Wiltrout, Robert H AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA. Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 7130 EP - 7136 VL - 68 IS - 17 KW - Interleukin-6 KW - 0 KW - Tumor Necrosis Factor-alpha KW - Nitric Oxide KW - 31C4KY9ESH KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Animals KW - Apoptosis KW - Interleukin-6 -- metabolism KW - Mice, Inbred C57BL KW - Interferon-gamma -- metabolism KW - Mice KW - Flow Cytometry KW - Tumor Necrosis Factor-alpha -- metabolism KW - Immunohistochemistry KW - Mice, Knockout KW - Nitric Oxide -- physiology KW - Neoplasms, Experimental -- metabolism KW - Neoplasms, Experimental -- pathology KW - Inflammation -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69488281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Nitric+oxide+is+a+key+component+in+inflammation-accelerated+tumorigenesis.&rft.au=Hussain%2C+S+Perwez%3BHe%2C+Peijun%3BSubleski%2C+Jeffery%3BHofseth%2C+Lorne+J%3BTrivers%2C+Glenwood+E%3BMechanic%2C+Leah%3BHofseth%2C+Anne+B%3BBernard%2C+Mark%3BSchwank%2C+Jonathan%3BNguyen%2C+Giang%3BMathe%2C+Ewy%3BDjurickovic%2C+Draginja%3BHaines%2C+Diana%3BWeiss%2C+Jonathan%3BBack%2C+Timothy%3BGruys%2C+Eilene%3BLaubach%2C+Victor+E%3BWiltrout%2C+Robert+H%3BHarris%2C+Curtis+C&rft.aulast=Hussain&rft.aufirst=S&rft.date=2008-09-01&rft.volume=68&rft.issue=17&rft.spage=7130&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-0410 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nitric Oxide. 2002 Aug;7(1):1-10 [12175813] Cancer Cell. 2008 Jan;13(1):7-9 [18167335] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):143-8 [12518062] J Leukoc Biol. 2003 Feb;73(2):253-62 [12554802] Nat Rev Cancer. 2003 Apr;3(4):276-85 [12671666] Free Radic Biol Med. 2003 Apr 15;34(8):969-86 [12684082] Nat Rev Cancer. 2004 Jan;4(1):11-22 [14708024] Cancer Res. 2004 Oct 1;64(19):6849-53 [15466171] J Exp Med. 1984 Nov 1;160(5):1431-49 [6491601] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):522-6 [7678458] Br J Pharmacol. 1995 Feb;114(3):689-93 [7537593] Cytokine. 1995 Jul;7(5):408-16 [7578978] Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1054-9 [8577713] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2442-7 [8637893] J Immunol. 1996 Oct 15;157(8):3577-86 [8871658] Cancer Metastasis Rev. 1998 Mar;17(1):7-23 [9544420] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8823-8 [9671763] J Immunol. 1998 Oct 15;161(8):4122-8 [9780184] J Immunol. 1998 Dec 1;161(11):6014-21 [9834083] Cancer Res. 2006 Jul 1;66(13):6459-62 [16818612] Blood. 2006 Aug 1;108(3):804-11 [16861339] Immunol Rev. 2006 Aug;212:314-29 [16903923] Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1329-37 [16910780] Cell Cycle. 2006 Aug;5(15):1616-20 [16880745] J Neuroimmunol. 2000 Jun 26;105(2):109-14 [10742551] Mutat Res. 2000 Feb 14;447(2):287-303 [10751613] J Biol Chem. 2000 May 5;275(18):13427-30 [10788454] Cancer Res. 2000 May 1;60(9):2377-83 [10811113] Mol Med. 2000 May;6(5):347-73 [10952018] Biochem Biophys Res Commun. 2000 Nov 11;278(1):263-7 [11071882] Biochem Biophys Res Commun. 2001 Apr 20;282(5):1075-9 [11302723] Int Immunopharmacol. 2001 Aug;1(8):1421-41 [11515809] Chem Res Toxicol. 2002 Apr;15(4):527-35 [11952339] Nat Rev Cancer. 2002 Jul;2(7):489-501 [12094235] Cancer Cell. 2005 Mar;7(3):211-7 [15766659] Nat Immunol. 2005 Apr;6(4):331-7 [15785758] Nat Rev Immunol. 2005 Apr;5(4):296-306 [15803149] Cancer Lett. 2005 Aug 8;226(1):1-15 [16004928] Cancer Res. 2005 Oct 15;65(20):9132-6 [16230367] J Cell Biol. 2005 Dec 19;171(6):1023-34 [16365168] Science. 2005 Dec 23;310(5756):1966-70 [16373578] Nat Rev Cancer. 2006 Jul;6(7):521-34 [16794635] Ann Rheum Dis. 2006 Nov;65 Suppl 3:iii37-40 [17038470] Curr Top Microbiol Immunol. 2006;311:17-58 [17048704] N Engl J Med. 2006 Nov 9;355(19):2003-11 [17093251] Int J Cancer. 2007 Feb 15;120(4):796-805 [17096325] J Clin Invest. 2007 Dec;117(12):3660-3 [18060028] J Clin Invest. 2007 Dec;117(12):3846-56 [18060032] J Clin Invest. 2007 Dec;117(12):3988-4002 [18060036] Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16186-91 [12451176] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-0410 ER - TY - JOUR T1 - Common integration sites for MMTV in viral induced mouse mammary tumors. AN - 69481811; 18709449 AB - The paradigm of mammary cancer induction by the mouse mammary tumor virus (MMTV) is used to illustrate the body of evidence that supports the hypothesis that mammary epithelial stem/progenitor cells represent targets for oncogenic transformation. It is argued that this is not a special case applicable only to MMTV-induced mammary cancer, because MMTV acts as an environmental mutagen producing random interruptions in the somatic DNA of infected cells by insertion of proviral DNA copies. In addition to disrupting the host genome, the proviral DNA also influences gene expression through its associated enhancer sequences over significant inter-genomic distances. Genes commonly affected by MMTV insertion in multiple individual tumors include, the Wnt, FGF, RSpo gene families as well as eIF3e and Notch4. All of these gene families are known to play essential roles in stem cell maintenance and behavior in a variety of organs. The MMTV-induced mutations accumulate in cells that are long-lived and possess the properties of stem cells, namely, self-renewal and the capacity to produce divergent epithelial progeny through asymmetric division. The evidence shows that epithelial cells with these properties are present in normal mammary glands, may be infected with MMTV, become transformed to produce epithelial hyperplasia through MMTV-induced mutagenesis and progress to frank mammary malignancy. Retroviral marking via MMTV proviral insertion demonstrates that this process progresses from a single mammary epithelial cell that possesses all of the features ascribed to tissue-specific stem cells. JF - Journal of mammary gland biology and neoplasia AU - Callahan, Robert AU - Smith, Gilbert H AD - Mammary Gland Biology and Tumorigenesis Laboratory, National Cancer Institute, Building 37/Room 1118A, MSC4254, Bethesda, MD 20892, USA. rc54d@nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 309 EP - 321 VL - 13 IS - 3 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Epithelial Cells -- metabolism KW - Animals KW - Humans KW - Mice KW - Models, Biological KW - Signal Transduction KW - Female KW - Pregnancy KW - Mutagenesis KW - DNA, Viral -- metabolism KW - Mammary Tumor Virus, Mouse -- metabolism KW - Mammary Neoplasms, Animal -- pathology KW - Mammary Neoplasms, Animal -- virology KW - Mammary Tumor Virus, Mouse -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69481811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+mammary+gland+biology+and+neoplasia&rft.atitle=Common+integration+sites+for+MMTV+in+viral+induced+mouse+mammary+tumors.&rft.au=Callahan%2C+Robert%3BSmith%2C+Gilbert+H&rft.aulast=Callahan&rft.aufirst=Robert&rft.date=2008-09-01&rft.volume=13&rft.issue=3&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Journal+of+mammary+gland+biology+and+neoplasia&rft.issn=1573-7039&rft_id=info:doi/10.1007%2Fs10911-008-9092-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-03 N1 - Date created - 2008-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 1999 Oct 28;18(44):5973-81 [10557086] Oncogene. 2000 Feb 21;19(8):992-1001 [10713682] Clin Cancer Res. 2000 Apr;6(4):1273-8 [10778951] Int J Oncol. 2001 Jan;18(1):175-9 [11115556] Clin Cancer Res. 2001 Feb;7(2):283-4 [11234880] Cancer Res. 2001 Feb 15;61(4):1754-9 [11245493] Exp Mol Pathol. 2001 Jun;70(3):183-93 [11417997] Breast Cancer Res Treat. 2001 May;67(2):93-109 [11519870] Oncogene. 2001 Aug 30;20(38):5291-301 [11536042] Cancer Res. 2001 Dec 15;61(24):8811-9 [11751403] Oncogene. 2002 Jan 31;21(6):890-8 [11840334] FEBS Lett. 2002 Mar 6;514(1):49-54 [11904180] Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10567-70 [12149477] Nat Genet. 2002 Sep;32(1):153-9 [12185366] Mech Ageing Dev. 2002 Sep;123(11):1505-19 [12425957] Am J Pathol. 2002 Dec;161(6):2241-53 [12466138] N Engl J Med. 2002 Dec 19;347(25):1999-2009 [12490681] Cancer Res. 2003 May 1;63(9):2179-87 [12727837] J Mammary Gland Biol Neoplasia. 2000 Oct;5(4):393-407 [14973384] Cancer Res. 2004 Jun 15;64(12):4105-11 [15205319] J Mammary Gland Biol Neoplasia. 2004 Apr;9(2):145-63 [15300010] J Mammary Gland Biol Neoplasia. 2004 Apr;9(2):207-15 [15300014] Oncogene. 2004 Aug 12;23(36):6047-55 [15208658] Br J Cancer. 1968 Mar;22(1):77-82 [4296102] Nature. 1975 May 15;255(5505):197-200 [1143315] J Virol. 1992 Apr;66(4):2594-9 [1312643] Oncogene. 1997 Jun 19;14(24):2985-9 [9205106] DNA Cell Biol. 1997 Jul;16(7):839-47 [9260927] J Biol Chem. 1997 Sep 19;272(38):23477-80 [9295280] Development. 1998 May;125(10):1921-30 [9550724] Clin Cancer Res. 1998 Oct;4(10):2565-8 [9796992] Proc Soc Exp Biol Med. 1998 Dec;219(3):217-25 [9824544] Genes Chromosomes Cancer. 1999 Jul;25(3):251-60 [10379871] Gene. 1999 Jun 11;233(1-2):241-7 [10375641] J Natl Cancer Inst. 1956 Dec;17(6):701-801 [13385677] BMC Med. 2004 Jun 15;2:24 [15198801] Development. 2005 Feb;132(4):681-7 [15647322] Clin Cancer Res. 2005 May 1;11(9):3198-204 [15867213] J Virol. 2005 Aug;79(15):10093-6 [16014973] Endocr Relat Cancer. 2005 Sep;12(3):483-95 [16172188] Virology. 2006 Jan 20;344(2):292-5 [16271739] Nature. 2006 Feb 23;439(7079):993-7 [16395311] Am J Pathol. 2006 Mar;168(3):973-90 [16507912] J Pathol. 2006 Aug;209(4):436-44 [16710841] J Virol. 2006 Nov;80(22):11409-15 [16971449] Breast Cancer Res. 2006;8(4):R49 [16882347] Breast Cancer Res. 2007;9(1):R12 [17257424] Front Biosci. 2007;12:4020-33 [17485355] Nat Genet. 2007 Jun;39(6):759-69 [17468756] Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5 [17804805] Cancer Res. 2007 Sep 15;67(18):8960-5 [17875739] Science. 2007 Nov 16;318(5853):1108-13 [17932254] Retrovirology. 2007;4:73 [17931409] Gene Ther. 2008 Jan;15(2):143-53 [17972922] Breast Cancer Res. 2007;9(4):R42 [17626637] Cancer Sci. 2008 Feb;99(2):202-8 [18271916] Dev Growth Differ. 2008 May;50(4):229-43 [18366384] Endocr Rev. 2008 Apr;29(2):193-216 [18216218] Int J Cancer. 1975 Dec 15;16(6):922-31 [172460] IARC Sci Publ. 1979;23:43-90 [233006] Cell. 1982 Nov;31(1):99-109 [6297757] Cell. 1983 Jun;33(2):369-77 [6305506] Cancer Res. 1983 Dec;43(12 Pt 1):5879-82 [6315219] J Virol. 1986 May;58(2):619-25 [3009873] J Virol. 1987 Jan;61(1):66-74 [3023708] J Virol. 1989 May;63(5):1924-8 [2704070] Proc Natl Acad Sci U S A. 1990 Jan;87(1):170-3 [1688653] Cell Growth Differ. 1990 Oct;1(10):503-10 [2278881] J Virol. 1991 Aug;65(8):4550-4 [1712864] Mol Cell Biol. 1992 Jan;12(1):147-54 [1530875] Genes Dev. 1992 Mar;6(3):345-55 [1372276] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):740-4 [8380647] Cell. 1993 Jul 30;74(2):331-45 [8343960] Mol Biol Cell. 1993 Dec;4(12):1267-75 [8167409] Virology. 1994 Aug 15;203(1):52-62 [8030284] Dev Biol. 1994 Dec;166(2):415-30 [7813766] J Virol. 1995 Mar;69(3):1932-8 [7853537] Genet Anal Tech Appl. 1994;11(4):95-101 [7857691] Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2268-72 [7892260] Cell Growth Differ. 1995 May;6(5):563-77 [7544153] Cancer Res. 1995 Nov 15;55(22):5173-9 [7585568] Cancer Res. 1996 Apr 15;56(8):1775-85 [8620493] Development. 1996 Jul;122(7):2251-9 [8681805] Breast Cancer Res Treat. 1996;39(1):21-31 [8738603] Oncogene. 1997 Apr 24;14(16):1883-90 [9150355] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10911-008-9092-6 ER - TY - JOUR T1 - Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex. AN - 69480963; 18632984 AB - The cellular activity of Yondelis (trabectedin, Ecteinascidin 743, Et743) is known to depend on transcription-coupled nucleotide excision repair (TCR). However, the subsequent cellular effects of Et743 are not fully understood. Here we show that Et743 induces both transcription- and replication-coupled DNA double-strand breaks (DSBs) that are detectible by neutral COMET assay and as gamma-H2AX foci that colocalize with 53BP1, Mre11, Ser(1981)-pATM, and Thr(68)-pChk2. The transcription coupled-DSBs (TC-DSBs) induced by Et743 depended both on TCR and Mre11-Rad50-Nbs1 (MRN) and were associated with DNA-PK-dependent gamma-H2AX foci. In contrast to DNA-PK, ATM phosphorylated H2AX both in NER-proficient and -deficient cells, but its full activation was dependent on H2AX as well as DNA-PK, suggesting a positive feedback loop: DNA-PK-gamma-H2AX-ATM. Knocking-out H2AX or inactivating DNA-PK reduced Et743's antiproliferative activity, whereas ATM and MRN tended to act as survival factors. Our results highlight the interplays between ATM and DNA-PK and their impacts on H2AX phosphorylation and cell survival. They also suggest that gamma-H2AX may serve as a biomarker in patients treated with Et743 and that molecular profiling of tumors for TCR, MRN, ATM, and DNA-PK might be useful to anticipate tumor response to Et743 treatment. JF - Molecular biology of the cell AU - Guirouilh-Barbat, Josée AU - Redon, Christophe AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 3969 EP - 3981 VL - 19 IS - 9 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Cell Cycle Proteins KW - DNA-Binding Proteins KW - Dioxoles KW - H2AFX protein, human KW - Histones KW - MRE11A protein, human KW - NBN protein, human KW - Nuclear Proteins KW - Rad50 protein, human KW - Tetrahydroisoquinolines KW - DNA-Activated Protein Kinase KW - EC 2.7.11.1 KW - Prkdc protein, mouse KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - trabectedin KW - ID0YZQ2TCP KW - Index Medicus KW - Comet Assay KW - DNA Repair KW - Phosphorylation KW - DNA-Activated Protein Kinase -- metabolism KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Humans KW - Histones -- chemistry KW - Tetrahydroisoquinolines -- pharmacology KW - Models, Biological KW - Dioxoles -- pharmacology KW - Cell Survival KW - DNA Repair Enzymes -- metabolism KW - Transcription, Genetic KW - DNA Breaks, Double-Stranded KW - Nuclear Proteins -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69480963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+biology+of+the+cell&rft.atitle=Transcription-coupled+DNA+double-strand+breaks+are+mediated+via+the+nucleotide+excision+repair+and+the+Mre11-Rad50-Nbs1+complex.&rft.au=Guirouilh-Barbat%2C+Jos%C3%A9e%3BRedon%2C+Christophe%3BPommier%2C+Yves&rft.aulast=Guirouilh-Barbat&rft.aufirst=Jos%C3%A9e&rft.date=2008-09-01&rft.volume=19&rft.issue=9&rft.spage=3969&rft.isbn=&rft.btitle=&rft.title=Molecular+biology+of+the+cell&rft.issn=1939-4586&rft_id=info:doi/10.1091%2Fmbc.E08-02-0215 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-27 N1 - Date created - 2008-08-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2008 Feb 29;29(4):488-98 [18313386] Carcinogenesis. 2008 Mar;29(3):455-65 [18174245] Expert Opin Investig Drugs. 2003 Nov;12(11):1843-53 [14585059] Nucleic Acids Res. 2004;32(6):1886-93 [15047855] J Clin Oncol. 2004 Apr 15;22(8):1480-90 [15084621] Science. 2002 May 3;296(5569):922-7 [11934988] EMBO J. 2002 Jun 17;21(12):3000-8 [12065413] Cancer Res. 2002 Jun 15;62(12):3377-81 [12067978] Nature. 2002 Jul 18;418(6895):348-52 [12124628] Anticancer Drugs. 2002 Jul;13(6):545-55 [12172500] Cancer Chemother Pharmacol. 2002 Oct;50(4):309-19 [12357306] Mol Cancer Res. 2003 Jan;1(3):207-18 [12556560] Nature. 2003 Jan 30;421(6922):499-506 [12556884] Nat Cell Biol. 2003 Apr;5(4):320-9 [12652308] J Biol Chem. 2003 May 30;278(22):20303-12 [12660252] EMBO J. 2003 Oct 15;22(20):5612-21 [14532133] J Biomol Struct Dyn. 1993 Apr;10(5):793-818 [8318161] Biochemistry. 1996 Oct 15;35(41):13303-9 [8873596] Oncogene. 1997 Jul 10;15(2):159-67 [9244351] Clin Cancer Res. 1998 Aug;4(8):1977-83 [9717828] Genes Dev. 1998 Aug 15;12(16):2598-609 [9716411] Ann Oncol. 1998 Sep;9(9):981-7 [9818072] Genes Dev. 1999 Apr 1;13(7):768-85 [10197977] J Med Chem. 1999 Jul 15;42(14):2493-7 [10411470] Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7 [15546735] Cancer Res. 2004 Dec 15;64(24):9152-9 [15604286] Trends Pharmacol Sci. 2005 Mar;26(3):138-45 [15749159] Nature. 2005 Mar 31;434(7033):605-11 [15758953] Science. 2005 Apr 22;308(5721):551-4 [15790808] Oncogene. 2005 May 26;24(23):3726-36 [15782130] Cancer Res. 2005 Jun 15;65(12):5337-43 [15958581] Cell. 2005 Dec 29;123(7):1213-26 [16377563] Mol Cell. 2006 Jan 20;21(2):187-200 [16427009] DNA Repair (Amst). 2006 May 10;5(5):575-90 [16567133] Curr Opin Oncol. 2006 Jul;18(4):347-53 [16721129] Nat Struct Mol Biol. 2006 May;13(5):451-7 [16622404] Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9891-6 [16788066] Mol Cell. 2006 Jul 7;23(1):121-32 [16818236] Oncogene. 2004 Apr 15;23(17):3122-7 [15048089] Annu Rev Biochem. 2004;73:39-85 [15189136] DNA Repair (Amst). 2004 Aug-Sep;3(8-9):855-61 [15279770] J Nat Prod. 1990 Jul-Aug;53(4):771-92 [2095373] Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11456-60 [1454834] Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1584-8 [10677503] Mol Cell Biol. 2000 Jun;20(11):3977-87 [10805740] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6780-4 [10841573] J Cell Biol. 2000 Dec 25;151(7):1381-90 [11134068] Clin Cancer Res. 2001 Jan;7(1):185-91 [11205907] Eur J Cancer. 2001 Jan;37(1):97-105 [11165136] Int J Cancer. 2001 May 15;92(4):583-8 [11304695] Nat Med. 2001 May;7(5):584-90 [11329060] EMBO J. 2001 Jul 2;20(13):3554-64 [11432842] Nat Med. 2001 Aug;7(8):961-6 [11479630] Chem Biol. 2001 Nov;8(11):1033-49 [11731295] Curr Opin Investig Drugs. 2001 Nov;2(11):1631-8 [11763168] EMBO Rep. 2002 Mar;3(3):248-54 [11850399] Curr Opin Genet Dev. 2002 Apr;12(2):162-9 [11893489] Nat Rev Mol Cell Biol. 2002 May;3(5):317-27 [11988766] Trends Biochem Sci. 2006 Jul;31(7):402-10 [16774833] Cancer Res. 2006 Aug 15;66(16):8155-62 [16912194] J Biol Chem. 2006 Oct 13;281(41):30814-23 [16905549] DNA Repair (Amst). 2007 Jul 1;6(7):953-66 [17531546] Mol Cancer Res. 2007 Jul;5(7):713-24 [17634426] Mol Cell Biol. 2007 Aug;27(16):5806-18 [17515603] Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13062-7 [17656556] Mol Cell. 2007 Oct 12;28(1):134-46 [17936710] Nature. 2007 Nov 22;450(7169):509-14 [17965729] Cell Cycle. 2007 Nov 15;6(22):2760-7 [17986860] J Mol Biol. 2008 Jan 25;375(4):1152-64 [18054789] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1091/mbc.E08-02-0215 ER - TY - JOUR T1 - Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. AN - 69466873; 18552213 AB - Iron is essential for all cells but is toxic in excess, so iron absorption and distribution are tightly regulated. Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythrocytes and reduced Tfr1 expression is associated with anemia. The transcription factors STAT5A/B are activated by many cytokines, including erythropoietin. Stat5a/b(-/-) mice are severely anemic and die perinatally, but no link has been made to iron homeostasis. To study the function of STAT5A/B in vivo, we deleted the floxed Stat5a/b locus in hematopoietic cells with a Tie2-Cre transgene. These mice exhibited microcytic, hypochromic anemia, as did lethally irradiated mice that received a transplant of Stat5a/b(-/-) fetal liver cells. Flow cytometry and RNA analyses of erythroid cells from mutant mice revealed a 50% reduction in Tfr1 mRNA and protein. We detected STAT5A/B binding sites in the first intron of the Tfr1 gene and found that expression of constitutively active STAT5A in an erythroid cell line increased Tfr1 levels. Chromatin immunoprecipitation experiments confirmed the binding of STAT5A/B to these sites. We conclude that STAT5A/B is an important regulator of iron update in erythroid progenitor cells via its control of Tfr1 transcription. JF - Blood AU - Zhu, Bing-Mei AU - McLaughlin, Sara K AU - Na, Risu AU - Liu, Jie AU - Cui, Yongzhi AU - Martin, Cyril AU - Kimura, Akiko AU - Robinson, Gertraud W AU - Andrews, Nancy C AU - Hennighausen, Lothar AD - Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDKD), National Institutes of Health (NIH), Bethesda, MD 20892, USA. bingmei@mail.nih.gov Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 2071 EP - 2080 VL - 112 IS - 5 KW - DNA Primers KW - 0 KW - RNA, Messenger KW - Receptors, Transferrin KW - STAT5 Transcription Factor KW - Stat5a protein, mouse KW - Stat5b protein, mouse KW - Tfrc protein, mouse KW - Iron KW - E1UOL152H7 KW - Abridged Index Medicus KW - Index Medicus KW - Hematopoiesis -- physiology KW - Animals KW - DNA Primers -- genetics KW - Gene Expression KW - Mice KW - RNA, Messenger -- genetics KW - Mice, Transgenic KW - Erythroid Precursor Cells -- metabolism KW - Iron -- metabolism KW - Fetal Tissue Transplantation KW - Mice, Knockout KW - Base Sequence KW - RNA, Messenger -- metabolism KW - Hepatocytes -- transplantation KW - Introns KW - Binding Sites -- genetics KW - Cell Line KW - Hematopoiesis -- genetics KW - Anemia, Hypochromic -- etiology KW - STAT5 Transcription Factor -- metabolism KW - Receptors, Transferrin -- deficiency KW - Receptors, Transferrin -- genetics KW - STAT5 Transcription Factor -- genetics KW - Anemia, Hypochromic -- metabolism KW - Anemia, Hypochromic -- genetics KW - STAT5 Transcription Factor -- deficiency KW - Receptors, Transferrin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69466873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Hematopoietic-specific+Stat5-null+mice+display+microcytic+hypochromic+anemia+associated+with+reduced+transferrin+receptor+gene+expression.&rft.au=Zhu%2C+Bing-Mei%3BMcLaughlin%2C+Sara+K%3BNa%2C+Risu%3BLiu%2C+Jie%3BCui%2C+Yongzhi%3BMartin%2C+Cyril%3BKimura%2C+Akiko%3BRobinson%2C+Gertraud+W%3BAndrews%2C+Nancy+C%3BHennighausen%2C+Lothar&rft.aulast=Zhu&rft.aufirst=Bing-Mei&rft.date=2008-09-01&rft.volume=112&rft.issue=5&rft.spage=2071&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2007-12-127480 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 2000 Aug 1;96(3):1113-8 [10910930] Annu Rev Physiol. 2007;69:69-85 [17014365] J Biol Chem. 2000 Sep 22;275(38):29338-47 [10882725] Dev Biol. 2001 Feb 15;230(2):230-42 [11161575] Blood. 2001 Dec 1;98(12):3261-73 [11719363] J Biol Chem. 2003 Dec 19;278(51):51261-6 [14532269] Br J Haematol. 2004 Jan;124(1):123-4 [14675418] Cell. 2004 Apr 30;117(3):285-97 [15109490] J Clin Invest. 2004 May;113(9):1271-6 [15124018] Mol Cell Biol. 2004 Sep;24(18):8037-47 [15340066] J Biol Chem. 2004 Sep 24;279(39):40640-6 [15280353] Mol Endocrinol. 1988 Nov;2(11):1027-32 [2464745] J Biol Chem. 1991 Apr 15;266(11):6909-14 [2016304] J Biol Chem. 1992 Apr 25;267(12):8254-9 [1569079] Eur J Biochem. 1994 Mar 15;220(3):683-92 [8143723] Blood. 1994 Sep 15;84(6):1697-702 [8080980] Cell. 1995 Oct 6;83(1):59-67 [7553874] Nucleic Acids Res. 1997 Nov 1;25(21):4323-30 [9336464] Cell. 1998 May 1;93(3):385-95 [9590173] Cell. 1998 May 1;93(3):397-409 [9590174] Cell. 1998 May 29;93(5):841-50 [9630227] Mol Cell Biol. 1998 Jul;18(7):3871-9 [9632771] Biol Signals Recept. 1998 May-Jun;7(3):157-78 [9672759] Nat Genet. 1999 Apr;21(4):396-9 [10192390] Cell. 1999 Jul 23;98(2):181-91 [10428030] J Biol Chem. 2006 Feb 10;281(6):3190-7 [16339156] Blood. 2006 Jul 1;108(1):404-5 [16790587] Comment In: Blood. 2008 Sep 1;112(5):1553-4 [18725572] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2007-12-127480 ER - TY - JOUR T1 - Riluzole in psychiatry: a systematic review of the literature. AN - 69458224; 18721116 AB - The glutamate system seems to be an important contributor to the pathophysiology of mood and anxiety disorders. Thus, glutamatergic modulators are reasonable candidate drugs to test in patients with mood and anxiety disorders. Riluzole, a neuroprotective agent with anticonvulsant properties approved for the treatment of amyotrophic lateral sclerosis (ALS) is one such agent. To assess the potential risks and benefits of riluzole treatment in psychiatric patients. A PubMed search was performed using the keywords 'riluzole', 'inhibitor of glutamate release' and 'glutamatergic modulator' to identify all clinical studies and case reports involving riluzole in psychiatric patients. Riluzole's side effect profile is favorable and preliminary results regarding riluzole for the treatment of severe mood, anxiety and impulsive disorders are encouraging. JF - Expert opinion on drug metabolism & toxicology AU - Zarate, Carlos A AU - Manji, Husseini K AD - Mark O Hatfield CRC, Bethesda, Maryland 20892, USA. zaratec@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1223 EP - 1234 VL - 4 IS - 9 SN - 1742-5255, 1742-5255 KW - Neuroprotective Agents KW - 0 KW - Riluzole KW - 7LJ087RS6F KW - Index Medicus KW - Animals KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Humans KW - Clinical Trials as Topic KW - Male KW - Female KW - Riluzole -- adverse effects KW - Riluzole -- pharmacokinetics KW - Neuroprotective Agents -- administration & dosage KW - Mental Disorders -- drug therapy KW - Riluzole -- administration & dosage KW - Neuroprotective Agents -- adverse effects KW - Neuroprotective Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69458224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Riluzole+in+psychiatry%3A+a+systematic+review+of+the+literature.&rft.au=Zarate%2C+Carlos+A%3BManji%2C+Husseini+K&rft.aulast=Zarate&rft.aufirst=Carlos&rft.date=2008-09-01&rft.volume=4&rft.issue=9&rft.spage=1223&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.4.9.1223 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-10 N1 - Date created - 2008-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Pharmacother. 2000 Mar;34(3):322-4 [10917377] N Engl J Med. 2000 Aug 31;343(9):665-6 [10979814] Neurobiol Dis. 2000 Aug;7(4):375-83 [10964608] Eur J Neurosci. 2000 Oct;12(10):3567-74 [11029626] Biol Psychiatry. 2000 Oct 15;48(8):813-29 [11063977] Neuropsychobiology. 2001;43(2):91-5 [11174052] J Neurosurg. 2001 Apr;94(2 Suppl):245-56 [11302627] Brain Res. 2001 Jun 8;903(1-2):222-5 [11382406] Am J Gastroenterol. 2001 Jul;96(7):2268-9 [11467672] Neurosci Lett. 2001 Sep 14;310(2-3):117-20 [11585581] J Neurol Sci. 2001 Oct 15;191(1-2):121-5 [11677002] Drug Metab Rev. 2001 Aug-Nov;33(3-4):273-97 [11768770] Neuropharmacology. 2002 Feb;42(2):199-209 [11804616] Parkinsonism Relat Disord. 2002 Mar;8(4):271-6 [12039422] Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Mar;3(1):23-9 [12061945] FASEB J. 2002 Aug;16(10):1328-30 [12154010] Depress Anxiety. 2002;16(1):4-13 [12203668] Mult Scler. 2002 Dec;8(6):532-3 [12474997] Toxicology. 2002 Dec 27;181-182:453-6 [12505351] J Neurosci. 2003 Mar 1;23(5):1688-96 [12629173] Psychopharmacology (Berl). 2003 May;167(2):219-20 [12658528] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 5;791(1-2):337-43 [12798193] Neuropsychobiology. 2003;48(1):27-30 [12886037] Clin Auton Res. 2003 Aug;13(4):271-4 [12955551] Neurology. 2003 Oct 28;61(8):1141-3 [14581684] Am J Psychiatry. 2004 Jan;161(1):171-4 [14702270] Neurosci Lett. 2004 Mar 18;358(1):37-40 [15016429] Expert Rev Neurother. 2008 Jan;8(1):93-110 [18088203] Eur J Pharmacol. 2008 Jan 14;578(2-3):171-6 [18036519] Curr Opin Pharmacol. 2008 Feb;8(1):14-9 [18061540] Cell Mol Neurobiol. 2004 Feb;24(1):123-8 [15049516] Neuroscience. 2004;125(1):191-201 [15051158] J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 25;803(2):305-9 [15063340] Psychopharmacology (Berl). 2004 Apr;173(1-2):227-8 [14722708] Ann Emerg Med. 2004 Feb;43(2):294 [15083846] J Clin Psychiatry. 1983 Aug;44(8 Pt 2):8-11 [6874657] Neuropharmacology. 1985 Nov;24(11):1085-92 [3001571] Am J Psychiatry. 1988 Mar;145(3):293-300 [3344844] Psychopharmacology (Berl). 1989;99(4):515-9 [2574482] J Clin Psychiatry. 1992 Mar;53 Suppl:9-13 [1548256] Eur J Pharmacol. 1993 Apr 28;235(2-3):283-9 [7685290] Am J Psychiatry. 1993 Aug;150(8):1257-8 [8328574] N Engl J Med. 1994 Mar 3;330(9):585-91 [8302340] Eur J Pharmacol. 1993 Dec 21;250(3):473-6 [8112408] Eur J Pharmacol. 1995 Sep 25;284(3):299-307 [8666012] Neuron. 1996 Mar;16(3):675-86 [8785064] Lancet. 1996 May 25;347(9013):1425-31 [8676624] Lancet. 1996 Sep 21;348(9030):795-9 [8813989] Ann Pharmacother. 1997 Jun;31(6):738-44 [9184716] J Pharmacol Exp Ther. 1997 Sep;282(3):1465-72 [9316860] J Hepatol. 1999 Mar;30(3):527-30 [10190739] Clin Pharmacokinet. 1999 Jun;36(6):439-52 [10427468] Biol Psychiatry. 2005 Feb 15;57(4):430-2 [15705360] Addiction. 2005 Mar;100 Suppl 1:12-22 [15730346] Br J Clin Pharmacol. 2005 Mar;59(3):310-3 [15752377] Eur J Neurosci. 2005 Mar;21(5):1304-14 [15813940] Neuroreport. 2005 Jul 13;16(10):1087-90 [15973153] Neurology. 2003 Oct 28;61(8):1150-1 [14581688] Biol Psychiatry. 2005 Sep 1;58(5):424-8 [15993857] Am J Psychiatry. 2005 Dec;162(12):2379-81 [16330605] Neuroscience. 2006;137(1):241-51 [16289892] J Clin Psychiatry. 2005 Nov;66(11):1492-3 [16420092] NeuroRx. 2006 Jan;3(1):69-81 [16490414] J Clin Psychopharmacol. 2006 Apr;26(2):218-20 [16633160] Biol Psychiatry. 2006 Jun 1;59(11):1006-20 [16487491] Eur J Neurol. 2006 Oct;13(10):1146-8 [16987170] J Clin Psychopharmacol. 2006 Dec;26(6):685-7 [17110840] Neurology. 2006 Dec 26;67(12):2260-1 [17190960] Can J Psychiatry. 2006 Nov;51(13):823-35 [17195602] Cochrane Database Syst Rev. 2007;(1):CD001447 [17253460] J Clin Psychiatry. 2007 Jan;68(1):170-1 [17284151] Cell Mol Neurobiol. 2007 Mar;27(2):171-7 [16758318] Biol Psychiatry. 2007 Mar 15;61(6):822-5 [17141740] Neuropsychopharmacology. 2007 Apr;32(4):793-802 [16936714] Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4647-52 [17360578] Prog Neuropsychopharmacol Biol Psychiatry. 2007 Apr 13;31(3):658-63 [17257729] J Clin Neurosci. 2007 Jul;14(7):658-65 [17532502] Curr Opin Investig Drugs. 2007 Jul;8(7):555-62 [17659475] J Neurochem. 2007 Oct;103(1):164-73 [17635670] Ann Neurol. 2007 Sep;62(3):262-72 [17702031] Neuropharmacology. 2007 Oct;53(5):609-18 [17714743] Neuropsychopharmacology. 2008 Jan;33(1):110-33 [17912251] Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5671-6 [18055818] J Child Adolesc Psychopharmacol. 2007 Dec;17(6):761-7 [18315448] Biol Psychiatry. 2008 May 1;63(9):891-8 [18028881] Biopharm Drug Dispos. 2008 Apr;29(3):139-44 [18098330] Eur J Pharmacol. 2008 May 31;586(1-3):164-70 [18423440] Neurosci Lett. 1999 Dec 3;276(2):127-30 [10624808] Eur Neurol. 2000;43(4):224-7 [10828653] Brain Res. 2000 Jul 21;871(2):175-80 [10899284] Br J Pharmacol. 2000 Jul;130(6):1227-34 [10903959] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.4.9.1223 ER - TY - JOUR T1 - Combinatorial antileukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide 2-(2,4-difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and flavopiridol. AN - 69457872; 18556456 AB - 2-(2,4-Difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) is a member of a recently identified class of redox-reactive thalidomide analogs that show selective killing of leukemic cells by increasing intracellular reactive oxygen species (ROS) and targeting multiple transcriptional pathways. Flavopiridol is a semisynthetic flavonoid that inhibits cyclin-dependent kinases and also shows selective lethality against leukemic cells. The purpose of this study is to explore the efficacy and mechanism of action of the combinatorial use of the redox-reactive thalidomide CPS49 and the cyclin-dependent kinase inhibitor flavopiridol as a selective antileukemic therapeutic strategy. In combination, CPS49 and flavopiridol were found to induce selective cytotoxicity associated with mitochondrial dysfunction and elevations of ROS in leukemic cells ranging from additive to synergistic activity at low micromolar concentrations. Highest synergy was observed at the level of ROS generation with a strong correlation between cell-specific cytotoxicity and reciprocal coupling of drug-induced ROS elevation with glutathione depletion. Examination of the transcriptional targeting of CPS49 and flavopiridol combinations reveals that the drugs act in concert to initiate a cell specific transcriptional program that manipulates nuclear factor-kappaB (NF-kappaB), E2F-1, and p73 activity to promote enhanced mitochondrial instability by simultaneously elevating the expression of the proapoptotic factors BAX, BAD, p73, and PUMA while depressing expression of the antiapoptotic genes MCL1, XIAP, BCL-xL, SURVIVIN, and MDM2. The coadministration of CPS49 and flavopiridol acts through coordinate targeting of transcriptional pathways that enforce selective mitochondrial dysfunction and ROS elevation and is therefore a promising new therapeutic combination that warrants further preclinical exploration. JF - Molecular pharmacology AU - Ge, Yun AU - Byun, Jung S AU - De Luca, Paola AU - Gueron, Geraldine AU - Yabe, Idalia M AU - Sadiq-Ali, Sara G AU - Figg, William D AU - Quintero, Jesse AU - Haggerty, Cynthia M AU - Li, Quentin Q AU - De Siervi, Adriana AU - Gardner, Kevin AD - Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD 20892-5065, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 872 EP - 883 VL - 74 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Apoptosis Regulatory Proteins KW - BBC3 protein, human KW - CPS 49 KW - DNA-Binding Proteins KW - Flavonoids KW - Free Radical Scavengers KW - NF-kappa B KW - Nuclear Proteins KW - Piperidines KW - Proto-Oncogene Proteins KW - Reactive Oxygen Species KW - Tumor Suppressor Proteins KW - alvocidib KW - 45AD6X575G KW - Thalidomide KW - 4Z8R6ORS6L KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Drug Screening Assays, Antitumor KW - Transcription, Genetic -- drug effects KW - Oxidation-Reduction -- drug effects KW - Dose-Response Relationship, Drug KW - Intracellular Space -- metabolism KW - Glutathione -- metabolism KW - Humans KW - Proto-Oncogene Proteins -- metabolism KW - Cell Line, Tumor KW - Cell Death -- drug effects KW - Membrane Potential, Mitochondrial -- drug effects KW - Intracellular Space -- drug effects KW - Tumor Suppressor Proteins -- metabolism KW - Organ Specificity -- drug effects KW - Apoptosis Regulatory Proteins -- metabolism KW - Nuclear Proteins -- metabolism KW - Drug Synergism KW - Free Radical Scavengers -- pharmacology KW - NF-kappa B -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Piperidines -- pharmacology KW - Leukemia -- pathology KW - Mitochondria -- drug effects KW - Flavonoids -- pharmacology KW - Thalidomide -- pharmacology KW - Homeostasis -- drug effects KW - Antineoplastic Agents -- pharmacology KW - Thalidomide -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69457872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Combinatorial+antileukemic+disruption+of+oxidative+homeostasis+and+mitochondrial+stability+by+the+redox+reactive+thalidomide+2-%282%2C4-difluoro-phenyl%29-4%2C5%2C6%2C7-tetrafluoro-1H-isoindole-1%2C3%282H%29-dione+%28CPS49%29+and+flavopiridol.&rft.au=Ge%2C+Yun%3BByun%2C+Jung+S%3BDe+Luca%2C+Paola%3BGueron%2C+Geraldine%3BYabe%2C+Idalia+M%3BSadiq-Ali%2C+Sara+G%3BFigg%2C+William+D%3BQuintero%2C+Jesse%3BHaggerty%2C+Cynthia+M%3BLi%2C+Quentin+Q%3BDe+Siervi%2C+Adriana%3BGardner%2C+Kevin&rft.aulast=Ge&rft.aufirst=Yun&rft.date=2008-09-01&rft.volume=74&rft.issue=3&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/10.1124%2Fmol.107.040808 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-08-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cancer Ther. 2004 Dec;3(12):1513-24 [15634644] Cell Cycle. 2004 Dec;3(12):1537-42 [15539947] Oncogene. 2005 Mar 10;24(11):1904-13 [15674346] Leukemia. 2005 Jul;19(7):1253-61 [15858615] Cell Death Differ. 2005 Nov;12 Suppl 2:1478-80 [16247494] J Biol Chem. 2004 Feb 6;279(6):4750-9 [14630924] Drug Resist Updat. 2004 Apr;7(2):97-110 [15158766] Anticancer Drugs. 2004 Jun;15(5):411-9 [15166614] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4192-7 [15217957] Clin Cancer Res. 2004 Jun 15;10(12 Pt 2):4270s-4275s [15217973] Mol Cancer Ther. 2004 Jul;3(7):873-5 [15252148] Adv Enzyme Regul. 1984;22:27-55 [6382953] J Clin Oncol. 1998 Sep;16(9):2986-99 [9738567] EMBO J. 1999 Jul 1;18(13):3586-95 [10393175] Arzneimittelforschung. 1953 Jun;3(6):285-90 [13081480] Oncogene. 2006 Aug 7;25(34):4812-30 [16892093] Cancer Cell. 2006 Sep;10(3):241-52 [16959615] Blood. 2006 Dec 15;108(13):4126-35 [16940421] Mol Cancer Ther. 2007 Feb;6(2):692-702 [17308065] Oncogene. 1999 Dec 16;18(54):7719-30 [10618712] Mol Cell Biol. 2000 Aug;20(15):5680-9 [10891504] J Clin Immunol. 2005 Nov;25(6):541-50 [16380818] J Clin Oncol. 2006 Apr 10;24(11):1770-83 [16603719] Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3502-9 [16740776] Nature. 2000 Oct 5;407(6804):645-8 [11034215] Cancer Res. 2001 Feb 15;61(4):1598-603 [11245471] Crit Rev Oncol Hematol. 2001 May;38(2):139-70 [11311660] Cell Death Differ. 2001 Jul;8(7):715-24 [11464216] J Biol Chem. 2001 Aug 24;276(34):31793-9 [11431468] Genome Biol. 2001;2(10):RESEARCH0041 [11597333] Leukemia. 2002 Apr;16(4):444-54 [11960321] J Clin Oncol. 2002 Oct 1;20(19):4074-82 [12351605] Cancer Res. 2003 Jan 1;63(1):93-9 [12517783] Drug Resist Updat. 2003 Feb;6(1):15-26 [12654284] Semin Cancer Biol. 2003 Apr;13(2):107-14 [12654254] Methods Mol Biol. 2003;223:543-54 [12777750] Cancer Res. 2003 Jun 15;63(12):3189-94 [12810647] EMBO J. 2003 Jul 1;22(13):3337-45 [12839995] Curr Opin Pharmacol. 2003 Aug;3(4):362-70 [12901944] Apoptosis. 2003 Oct;8(5):461-8 [12975577] Clin Cancer Res. 2003 Oct 1;9(12):4586-94 [14555534] Cancer Res. 2003 Nov 1;63(21):7410-22 [14612540] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/mol.107.040808 ER - TY - JOUR T1 - Eye malformations in children with heavy alcohol exposure in utero. AN - 69456621; 18571671 AB - To determine whether children who do not develop fetal alcohol syndrome (FAS) despite heavy alcohol exposure are at risk for eye abnormalities. We screened 9628 pregnant women and identified 101 women who were drinking >/= 2 oz of absolute alcohol per day and 101 nondrinking control women. We followed 43 exposed and 55 control offspring between age 4 and 9 years, performing masked standardized ophthalomologic examinations. The groups did not differ in their rates of impaired visual acuity, refractory errors, ptosis, epicanthal folds, or short palpebral fissures. Biomicroscopy examination was normal in all exposed subjects; cataracts were detected in 2 control subjects (4%) but in no exposed subjects. Arterial tortuosity was seen in 7 exposed subjects (16%) and in 8 control subjects (15%). Optic nerve hypoplasia was not detected in any subject. Previous research has found that children with FAS have a high incidence of serious ophthalmologic defects; our data indicate that the risk is limited to children with FAS and does not extend to children exposed to high levels of alcohol prenatally who do not develop FAS. Eye examinations are unlikely to clarify the diagnosis in children suspected of having alcohol-related damage. JF - The Journal of pediatrics AU - Flanigan, Elizabeth Y AU - Aros, Sofia AU - Bueno, Maria Ferraz AU - Conley, Mary AU - Troendle, James F AU - Cassorla, Fernando AU - Mills, James L AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 391 EP - 395 VL - 153 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Child KW - Pregnancy KW - Child, Preschool KW - Fetal Alcohol Spectrum Disorders -- etiology KW - Infant KW - Refraction, Ocular KW - Prospective Studies KW - Risk Factors KW - Adult KW - Incidence KW - Follow-Up Studies KW - Adolescent KW - United States -- epidemiology KW - Time Factors KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Visual Acuity KW - Male KW - Female KW - Fetal Alcohol Spectrum Disorders -- diagnosis KW - Maternal Exposure -- adverse effects KW - Eye Abnormalities -- diagnosis KW - Alcohol Drinking -- adverse effects KW - Eye Abnormalities -- epidemiology KW - Eye Abnormalities -- etiology KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69456621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pediatrics&rft.atitle=Eye+malformations+in+children+with+heavy+alcohol+exposure+in+utero.&rft.au=Flanigan%2C+Elizabeth+Y%3BAros%2C+Sofia%3BBueno%2C+Maria+Ferraz%3BConley%2C+Mary%3BTroendle%2C+James+F%3BCassorla%2C+Fernando%3BMills%2C+James+L&rft.aulast=Flanigan&rft.aufirst=Elizabeth&rft.date=2008-09-01&rft.volume=153&rft.issue=3&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pediatrics&rft.issn=1097-6833&rft_id=info:doi/10.1016%2Fj.jpeds.2008.04.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-09 N1 - Date created - 2008-08-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addict Biol. 2004 Jun;9(2):153-7; discussion 159-60 [15223541] Neurobehav Toxicol Teratol. 1984 Sep-Oct;6(5):373-7 [6514101] Neuropediatrics. 1981 Feb;12(1):97-8 [6789226] J Pediatr Ophthalmol Strabismus. 1981 Jul-Aug;18(4):6-15 [7264859] Birth Defects Orig Artic Ser. 1982;18(6):651-5 [6890860] J Pediatr Ophthalmol Strabismus. 1984 Jan-Feb;21(1):8-18 [6707858] J AAPOS. 2000 Aug;4(4):200-4 [10951294] Am J Obstet Gynecol. 2007 Jul;197(1):12-25 [17618743] Eur J Ophthalmol. 2007 Jan-Feb;17(1):104-9 [17294389] Neurosci Biobehav Rev. 2007;31(2):221-9 [16908065] PLoS Med. 2006 May;3(5):e247; author reply e248 [16719552] Subst Use Misuse. 2006;41(2):183-97 [16479683] J Pediatr. 2005 Oct;147(4):473-9 [16227033] Am J Public Health. 2005 Jul;95(7):1190-9 [15933241] J AAPOS. 1999 Aug;3(4):212-20 [10477223] Eur J Ophthalmol. 1997 Jul-Sep;7(3):262-70 [9352281] J Pediatr Ophthalmol Strabismus. 1997 Jan-Feb;34(1):17-23 [9027675] Acta Paediatr. 1996 Dec;85(12):1463-8 [9001659] Alcohol Clin Exp Res. 1996 Apr;20(2):359-63 [8730230] J Pediatr Ophthalmol Strabismus. 2001 Jul-Aug;38(4):219-23 [11495309] JAMA. 1981 Jan 9;245(2):108 [7452823] Pediatrics. 1996 Jun;97(6 Pt 1):845-50 [8657525] Graefes Arch Clin Exp Ophthalmol. 1995 Mar;233(3):150-3 [7758982] Br J Ophthalmol. 1991 Sep;75(9):524-6 [1911652] J Ment Defic Res. 1990 Oct;34 ( Pt 5):429-35 [2266551] Clin Pediatr (Phila). 1990 Mar;29(3):172-4 [2306903] Surv Ophthalmol. 1987 Jan-Feb;31(4):277-84 [3107154] Neurobehav Toxicol Teratol. 1985 May-Jun;7(3):263-6 [4033867] Acta Ophthalmol Suppl. 1985;171:1-50 [2988263] Alcohol Alcohol. 2002 Jan-Feb;37(1):2-8 [11825849] J Pediatr Ophthalmol. 1976 Sep-Oct;13(5):255-8 [828202] J Am Optom Assoc. 1984 Aug;55(8):595-8 [6541235] Lancet. 1973 Jun 9;1(7815):1267-71 [4126070] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jpeds.2008.04.024 ER - TY - JOUR T1 - Making the most of case-mother/control-mother studies. AN - 69455054; 18650222 AB - The prenatal environment plays an important role in many conditions, particularly those with onset early in life, such as childhood cancers and birth defects. Because both maternal and fetal genotypes can influence risk, investigators sometimes use a case-mother/control-mother design, with mother-offspring pairs as the unit of analysis, to study genetic factors. Risk models should account for both the maternal genotype and the correlated fetal genotype to avoid confounding. The usual logistic regression analysis, however, fails to fully exploit the fact that these are mothers and offspring. Consider an autosomal, diallelic locus, which could be related to disease susceptibility either directly or through linkage with a polymorphic causal locus. Three nested levels of assumptions are often natural and plausible. The first level simply assumes Mendelian inheritance. The second further assumes parental mating symmetry for the studied locus in the source population. The third additionally assumes parental allelic exchangeability. Those assumptions imply certain nonlinear constraints; the authors enforce those constraints by using Poisson regression together with the expectation-maximization algorithm. Calculations reveal that improvements in efficiency over the usual logistic analysis can be substantial, even if only the Mendelian assumption is honored. Benefits are even more marked if, as is typical, information on genotype is missing for some individuals. JF - American journal of epidemiology AU - Shi, M AU - Umbach, D M AU - Vermeulen, S H AU - Weinberg, C R AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 541 EP - 547 VL - 168 IS - 5 KW - Index Medicus KW - Genetic Linkage KW - Polymorphism, Single Nucleotide KW - Humans KW - Algorithms KW - Poisson Distribution KW - Pregnancy KW - Genotype KW - Alleles KW - Logistic Models KW - Risk Factors KW - Models, Genetic KW - North Carolina KW - Adult KW - Case-Control Studies KW - Environmental Exposure KW - Genetic Predisposition to Disease KW - Parents KW - Netherlands KW - Female KW - Fetus KW - Prenatal Care -- methods KW - Mothers KW - Prenatal Exposure Delayed Effects -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69455054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Making+the+most+of+case-mother%2Fcontrol-mother+studies.&rft.au=Shi%2C+M%3BUmbach%2C+D+M%3BVermeulen%2C+S+H%3BWeinberg%2C+C+R&rft.aulast=Shi&rft.aufirst=M&rft.date=2008-09-01&rft.volume=168&rft.issue=5&rft.spage=541&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn149 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-31 N1 - Date created - 2008-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1996 Mar 9;347(9002):686-7 [8596396] J Natl Cancer Inst. 2000 Jul 19;92(14):1151-8 [10904088] Am J Hum Genet. 2000 Jan;66(1):335-8 [10631165] Am J Hum Genet. 2000 Jan;66(1):251-61 [10631155] Genet Epidemiol. 2005 Feb;28(2):138-56 [15593088] Am J Epidemiol. 1998 Nov 1;148(9):893-901 [9801020] Am J Hum Genet. 1998 Apr;62(4):969-78 [9529360] Am J Hum Genet. 2007 Jul;81(1):53-66 [17564963] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn149 ER - TY - JOUR T1 - Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. AN - 69442426; 18586243 AB - The innate immune system senses the invasion of pathogenic microorganisms and tissue injury through Toll-like receptors (TLR), a mechanism thought to be limited to immune cells. We recently found that neurons express several TLRs, and that the levels of TLR2 and TLR4 are increased in neurons in response to energy deprivation. Here we report that TLR4 expression increases in neurons when exposed to amyloid beta-peptide (Abeta1-42) or the lipid peroxidation product 4-hydroxynonenal (HNE). Neuronal apoptosis triggered by Abeta and HNE was mediated by jun N-terminal kinase (JNK); neurons from TLR4 mutant mice exhibited reduced JNK and caspase-3 activation and were protected against apoptosis induced by Abeta and HNE. Levels of TLR4 were decreased in inferior parietal cortex tissue specimens from end-stage AD patients compared to aged-matched control subjects, possibly as the result of loss of neurons expressing TLR4. Our findings suggest that TLR4 signaling increases the vulnerability of neurons to Abeta and oxidative stress in AD, and identify TLR4 as a potential therapeutic target for AD. JF - Experimental neurology AU - Tang, Sung-Chun AU - Lathia, Justin D AU - Selvaraj, Pradeep K AU - Jo, Dong-Gyu AU - Mughal, Mohamed R AU - Cheng, Aiwu AU - Siler, Dominic A AU - Markesbery, William R AU - Arumugam, Thiruma V AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 114 EP - 121 VL - 213 IS - 1 KW - Aldehydes KW - 0 KW - Amyloid beta-Peptides KW - Membrane Lipids KW - Peptide Fragments KW - Tlr4 protein, mouse KW - Toll-Like Receptor 4 KW - amyloid beta-protein (1-42) KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Caspase 3 KW - EC 3.4.22.- KW - 4-hydroxy-2-nonenal KW - K1CVM13F96 KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Animals KW - Peptide Fragments -- toxicity KW - Caspase 3 -- drug effects KW - Humans KW - Membrane Lipids -- metabolism KW - Aged KW - Mice KW - Brain -- metabolism KW - JNK Mitogen-Activated Protein Kinases -- drug effects KW - Mice, Knockout KW - Amyloid beta-Peptides -- metabolism KW - Aged, 80 and over KW - Amyloid beta-Peptides -- toxicity KW - Brain -- pathology KW - Signal Transduction -- drug effects KW - Aldehydes -- metabolism KW - Male KW - Female KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Caspase 3 -- metabolism KW - Toll-Like Receptor 4 -- genetics KW - Nerve Degeneration -- metabolism KW - Alzheimer Disease -- drug therapy KW - Nerve Degeneration -- pathology KW - Apoptosis -- drug effects KW - Oxidative Stress -- drug effects KW - Nerve Degeneration -- chemically induced KW - Toll-Like Receptor 4 -- metabolism KW - Alzheimer Disease -- metabolism KW - Lipid Peroxidation KW - Alzheimer Disease -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69442426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Toll-like+receptor-4+mediates+neuronal+apoptosis+induced+by+amyloid+beta-peptide+and+the+membrane+lipid+peroxidation+product+4-hydroxynonenal.&rft.au=Tang%2C+Sung-Chun%3BLathia%2C+Justin+D%3BSelvaraj%2C+Pradeep+K%3BJo%2C+Dong-Gyu%3BMughal%2C+Mohamed+R%3BCheng%2C+Aiwu%3BSiler%2C+Dominic+A%3BMarkesbery%2C+William+R%3BArumugam%2C+Thiruma+V%3BMattson%2C+Mark+P&rft.aulast=Tang&rft.aufirst=Sung-Chun&rft.date=2008-09-01&rft.volume=213&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=1090-2430&rft_id=info:doi/10.1016%2Fj.expneurol.2008.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-15 N1 - Date created - 2008-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2004 Sep 15;173(6):3916-24 [15356140] Cell Physiol Biochem. 2007;20(6):947-56 [17982277] Biochem Biophys Res Commun. 2004 Nov 19;324(3):1087-94 [15485666] J Neurochem. 1988 Nov;51(5):1641-5 [3139840] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7951-5 [8367446] Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2696-701 [8610103] Brain Res. 1996 May 13;720(1-2):93-100 [8782901] J Neurochem. 1997 Jan;68(1):255-64 [8978733] J Neurosci. 1997 Feb 1;17(3):1046-54 [8994059] Am J Pathol. 1997 Feb;150(2):437-43 [9033259] J Neurochem. 1997 May;68(5):2092-7 [9109537] J Neurosci. 1997 Jul 1;17(13):5089-100 [9185546] J Neurochem. 1997 Jul;69(1):273-84 [9202320] Neurobiol Aging. 1997 Sep-Oct;18(5):457-61 [9390770] J Neurosci. 1998 Jan 15;18(2):687-97 [9425011] Brain Res. 1998 Mar 2;785(2):195-206 [9518610] Rev Neurosci. 1998;9(2):105-16 [9711902] Brain Res. 1998 Oct 5;807(1-2):167-76 [9757026] Ann Neurol. 1998 Nov;44(5):819-24 [9818940] Trends Neurosci. 1999 Sep;22(9):397-402 [10441300] Neurobiol Aging. 2005 Mar;26(3):349-54 [15639313] Alzheimer Dis Assoc Disord. 2005 Apr-Jun;19(2):55-66 [15942322] J Neurochem. 2005 Jul;94(2):289-98 [15998280] Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1069-76 [15863460] J Immunol. 2005 Oct 1;175(7):4320-30 [16177072] Immunogenetics. 2005 Jul;57(6):385-92 [16001129] Nat Med. 2005 Nov;11(11):1173-9 [16244651] J Biol Chem. 2006 Feb 10;281(6):3651-9 [16339765] J Neurosci Res. 2006 Apr;83(5):883-9 [16447284] J Neurosci Res. 2006 May 1;83(6):1039-47 [16511858] J Immunol. 2006 Jul 15;177(2):1272-81 [16818787] Neuroreport. 2006 Jul 31;17(11):1111-4 [16837837] Brain. 2006 Aug;129(Pt 8):2158-76 [16731541] Biochem Pharmacol. 2006 Oct 30;72(9):1102-13 [16930560] Shock. 2006 Nov;26(5):430-7 [17047512] J Neurochem. 2000 Jan;74(1):159-68 [10617117] J Neural Transm Suppl. 1999;57:315-22 [10666686] J Neurochem. 2001 Apr;77(1):157-64 [11279271] J Exp Med. 2002 Jan 7;195(1):99-111 [11781369] J Biol Chem. 2002 Apr 26;277(17):15028-34 [11836257] J Biol Chem. 2002 Apr 26;277(17):15107-12 [11842086] Infect Immun. 2002 Jul;70(7):3433-42 [12065483] Prog Lipid Res. 2003 Jul;42(4):318-43 [12689622] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8514-9 [12824464] Prog Neurobiol. 2003 Aug;70(6):463-72 [14568360] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2070-5 [14970312] Nature. 2004 Aug 5;430(7000):631-9 [15295589] J Leukoc Biol. 2004 Sep;76(3):514-9 [15178705] J Cell Biol. 2006 Oct 23;175(2):209-15 [17060494] Brain. 2006 Nov;129(Pt 11):3006-19 [16984903] J Mol Neurosci. 2006;29(3):185-94 [17085778] Curr Pharm Des. 2006;12(32):4123-34 [17100615] Mol Immunol. 2007 Apr;44(10):2625-30 [17239439] Nat Rev Immunol. 2007 Mar;7(3):179-90 [17318230] Mol Biol Evol. 2007 Mar;24(3):792-804 [17190971] Semin Immunol. 2007 Feb;19(1):33-40 [17336545] J Neurochem. 2007 Jul;102(1):37-50 [17403033] Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13798-803 [17693552] Nat Cell Biol. 2007 Sep;9(9):1081-8 [17704767] Exp Mol Med. 2007 Aug 31;39(4):421-38 [17934330] J Neurosci. 2004 Sep 8;24(36):7879-87 [15356200] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.expneurol.2008.05.014 ER - TY - JOUR T1 - The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. AN - 69440873; 18641653 AB - The physiological function of the adaptor protein TRADD remains unclear because of the unavailability of a TRADD-deficient animal model. By generating TRADD-deficient mice, we found here that TRADD serves an important function in tumor necrosis factor receptor 1 (TNFR1) signaling by orchestrating the formation of TNFR1 signaling complexes. TRADD was essential for TNFR1 signaling in mouse embryonic fibroblasts but was partially dispensable in macrophages; abundant expression of the adaptor RIP in macrophages may have allowed some transmission of TNFR1 signals in the absence of TRADD. Although morphologically normal, TRADD-deficient mice were resistant to toxicity induced by TNF, lipopolysaccharide and polyinosinic-polycytidylic acid. TRADD was also required for TRIF-dependent Toll-like receptor signaling in mouse embryonic fibroblasts but not macrophages. Our findings definitively establish the biological function of TRADD in TNF signaling. JF - Nature immunology AU - Pobezinskaya, Yelena L AU - Kim, You-Sun AU - Choksi, Swati AU - Morgan, Michael J AU - Li, Tao AU - Liu, Chengyu AU - Liu, Zhenggang AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1047 EP - 1054 VL - 9 IS - 9 KW - TNF Receptor-Associated Death Domain Protein KW - 0 KW - TNF Receptor-Associated Factor 1 KW - Toll-Like Receptors KW - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins KW - Ubiquitin KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Animals KW - Ubiquitin -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Mice KW - Fibroblasts -- metabolism KW - Macrophages -- metabolism KW - TNF Receptor-Associated Death Domain Protein -- metabolism KW - TNF Receptor-Associated Factor 1 -- metabolism KW - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins -- genetics KW - TNF Receptor-Associated Death Domain Protein -- deficiency KW - Signal Transduction -- drug effects KW - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins -- physiology KW - Toll-Like Receptors -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69440873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+immunology&rft.atitle=The+function+of+TRADD+in+signaling+through+tumor+necrosis+factor+receptor+1+and+TRIF-dependent+Toll-like+receptors.&rft.au=Pobezinskaya%2C+Yelena+L%3BKim%2C+You-Sun%3BChoksi%2C+Swati%3BMorgan%2C+Michael+J%3BLi%2C+Tao%3BLiu%2C+Chengyu%3BLiu%2C+Zhenggang&rft.aulast=Pobezinskaya&rft.aufirst=Yelena&rft.date=2008-09-01&rft.volume=9&rft.issue=9&rft.spage=1047&rft.isbn=&rft.btitle=&rft.title=Nature+immunology&rft.issn=1529-2916&rft_id=info:doi/10.1038%2Fni.1639 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Pharmacol. 1989 Feb 15;38(4):627-31 [2465008] Nat Immunol. 2004 Feb;5(2):199-207 [14730360] Annu Rev Cell Biol. 1993;9:317-43 [8280464] Cell. 1995 May 19;81(4):495-504 [7758105] Cell. 1996 Jan 26;84(2):299-308 [8565075] Immunity. 1996 Apr;4(4):387-96 [8612133] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5860-5 [8650183] Cell. 1996 Oct 4;87(1):13-20 [8858144] Cell. 1997 Feb 7;88(3):355-65 [9039262] Immunity. 1997 Nov;7(5):715-25 [9390694] Science. 1998 Mar 20;279(5358):1954-8 [9506948] Nature. 1998 Mar 19;392(6673):296-300 [9521326] Immunity. 1998 Mar;8(3):297-303 [9529147] Immunity. 1999 Jul;11(1):115-22 [10435584] J Biol Chem. 2005 Nov 4;280(44):36560-6 [16115877] Mol Cell Biol. 2006 May;26(9):3505-13 [16611992] Mol Cell Biol. 2006 Nov;26(21):8136-48 [16940186] Mol Cell. 2007 Jun 8;26(5):675-87 [17560373] Curr Biol. 2007 Aug 21;17(16):1438-43 [17702576] Cytokine. 2008 Apr;42(1):55-61 [18331798] Immunity. 2008 May;28(5):651-61 [18439848] Immunol Today. 1992 May;13(5):151-3 [1322675] Cell. 2001 Feb 23;104(4):487-501 [11239407] Nat Immunol. 2000 Dec;1(6):489-95 [11101870] Trends Cell Biol. 2001 Sep;11(9):372-7 [11514191] J Biol Chem. 2001 Sep 28;276(39):36530-4 [11479302] Nature. 2001 Oct 18;413(6857):732-8 [11607032] Oncogene. 1999 Dec 16;18(54):7719-30 [10618712] Immunity. 2000 Mar;12(3):301-11 [10755617] Immunity. 2000 Apr;12(4):419-29 [10795740] Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1202-9 [10801288] J Biol Chem. 2004 Mar 12;279(11):10822-8 [14701813] Nat Immunol. 2004 May;5(5):503-7 [15064760] Nature. 2004 Aug 5;430(7000):694-9 [15258597] Rev Physiol Biochem Pharmacol. 1974;(71):77-106 [4375846] Science. 2002 May 31;296(5573):1634-5 [12040173] Cell Death Differ. 2003 Jan;10(1):45-65 [12655295] EMBO Rep. 2003 Jun;4(6):623-7 [12776182] Cell. 2003 Jul 25;114(2):181-90 [12887920] Science. 2003 Aug 1;301(5633):640-3 [12855817] Comment In: Nat Immunol. 2008 Sep;9(9):1015-6 [18711443] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/ni.1639 ER - TY - JOUR T1 - Urinary exosomal transcription factors, a new class of biomarkers for renal disease. AN - 69436385; 18509321 AB - Urinary exosomes are excreted from all nephron segments and constitute a rich source of intracellular kidney injury biomarkers. To study whether they contain transcription factors, we collected urine from two acute kidney injury models (cisplatin or ischemia-reperfusion), two podocyte injury models (puromycin-treated rats or podocin-Vpr transgenic mice) and from patients with focal segmental glomerulosclerosis, acute kidney injury and matched controls. Exosomes were isolated by differential centrifugation and found to contain activating transcription factor 3 (ATF3) and Wilms Tumor 1 (WT-1) proteins detected by Western blot. These factors were found in the concentrated exosomal fraction, but not in whole urine. ATF3 was continuously present in urine exosomes of the rat models following acute injury at times earlier than the increase in serum creatinine. ATF3 was found in exosomes isolated from patients with acute kidney injury but not from patients with chronic kidney disease or controls. Urinary WT-1 was present in animal models before significant glomerular sclerosis and in 9/10 patients with focal segmental glomerulosclerosis but not in 8 controls. Our findings suggest that transcription factor ATF3 may provide a novel renal tubular cell biomarker for acute kidney injury while WT-1 may detect early podocyte injury. Measurement of urinary exosomal transcription factors may offer insight into cellular regulatory pathways. JF - Kidney international AU - Zhou, Hua AU - Cheruvanky, Anita AU - Hu, Xuzhen AU - Matsumoto, Takayuki AU - Hiramatsu, Noriyuki AU - Cho, Monique E AU - Berger, Alexandra AU - Leelahavanichkul, Asada AU - Doi, Kent AU - Chawla, Lakhmir S AU - Illei, Gabor G AU - Kopp, Jeffrey B AU - Balow, James E AU - Austin, Howard A AU - Yuen, Peter S T AU - Star, Robert A AD - Renal Diagnostics and Therapeutics Unit, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 613 EP - 621 VL - 74 IS - 5 KW - Activating Transcription Factor 3 KW - 0 KW - Biomarkers KW - Gene Products, vpr KW - Intracellular Signaling Peptides and Proteins KW - Membrane Proteins KW - NPHS2 protein KW - Transcription Factors KW - WT1 Proteins KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Animals KW - Humans KW - Aged KW - Membrane Proteins -- genetics KW - Mice, Transgenic KW - Rats KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Podocytes -- pathology KW - Acute Kidney Injury -- chemically induced KW - Adult KW - WT1 Proteins -- urine KW - Reperfusion Injury -- urine KW - Podocytes -- drug effects KW - Podocytes -- physiology KW - Gene Products, vpr -- genetics KW - Male KW - Acute Kidney Injury -- urine KW - Activating Transcription Factor 3 -- urine KW - Glomerulosclerosis, Focal Segmental -- urine KW - Biomarkers -- urine KW - Mice KW - Rats, Sprague-Dawley KW - Cisplatin -- toxicity KW - Kidney -- injuries KW - Case-Control Studies KW - Middle Aged KW - Transcription Factors -- urine KW - Kidney Diseases -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69436385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Urinary+exosomal+transcription+factors%2C+a+new+class+of+biomarkers+for+renal+disease.&rft.au=Zhou%2C+Hua%3BCheruvanky%2C+Anita%3BHu%2C+Xuzhen%3BMatsumoto%2C+Takayuki%3BHiramatsu%2C+Noriyuki%3BCho%2C+Monique+E%3BBerger%2C+Alexandra%3BLeelahavanichkul%2C+Asada%3BDoi%2C+Kent%3BChawla%2C+Lakhmir+S%3BIllei%2C+Gabor+G%3BKopp%2C+Jeffrey+B%3BBalow%2C+James+E%3BAustin%2C+Howard+A%3BYuen%2C+Peter+S+T%3BStar%2C+Robert+A&rft.aulast=Zhou&rft.aufirst=Hua&rft.date=2008-09-01&rft.volume=74&rft.issue=5&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=1523-1755&rft_id=info:doi/10.1038%2Fki.2008.206 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-02 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73 [15326289] Am J Nephrol. 2004 Jul-Aug;24(4):438-47 [15308877] Am J Physiol. 1997 Feb;272(2 Pt 2):F160-6 [9124391] J Biol Chem. 1997 Aug 8;272(32):19943-50 [9242662] Nephrol Dial Transplant. 1997 Sep;12(9):1883-9 [9306339] Gene Expr. 1999;7(4-6):321-35 [10440233] Nephrol Dial Transplant. 2005 Jan;20(1):105-13 [15561743] J Am Soc Nephrol. 2005 Feb;16(2):408-16 [15625073] Lancet. 2005 Apr 2-8;365(9466):1231-8 [15811456] J Am Soc Nephrol. 2005 Jun;16(6):1733-41 [15829708] Cancer Res. 2005 Jul 15;65(14):6151-8 [16024616] J Am Soc Nephrol. 2005 Oct;16(10):3046-52 [16148039] J Am Soc Nephrol. 2005 Dec;16(12):3763-70 [16236805] N Engl J Med. 2005 Dec 1;353(22):2342-51 [16319383] Kidney Int. 2006 Jan;69(2):399-405 [16408133] Clin Chim Acta. 2006 Apr;366(1-2):243-8 [16313894] Nature. 2006 May 11;441(7090):173-8 [16688168] Pediatr Nephrol. 2006 Jun;21(6):856-63 [16528543] Physiol Genomics. 2006 May 16;25(3):375-86 [16507785] Kidney Int. 2006 Jun;69(12):2131-47 [16688120] Kidney Int. 2006 Jul;70(1):199-203 [16710348] J Biol Chem. 2006 Jul 7;281(27):18734-45 [16613840] Am J Transplant. 2006 Jul;6(7):1639-45 [16827865] Am J Nephrol. 2006;26(3):287-92 [16772710] Rheumatology (Oxford). 2006 Aug;45(8):951-7 [16461436] Kidney Int. 2006 Aug;70(3):496-506 [16760904] Anesthesiology. 2006 Sep;105(3):485-91 [16931980] Pediatr Nephrol. 2006 Nov;21(11):1653-60 [16927106] Eur J Clin Invest. 1999 Oct;29(10):824-6 [10583423] J Am Soc Nephrol. 2001 May;12(5):900-8 [11316848] Toxicol Sci. 2001 Oct;63(2):196-207 [11568363] Kidney Int. 2002 May;61(5):1646-54 [11967014] Microsc Res Tech. 2002 May 15;57(4):208-11 [12012385] Kidney Int. 2002 Nov;62(5):1601-10 [12371960] Am J Physiol Renal Physiol. 2003 Jan;284(1):F218-28 [12388413] Kidney Int. 2003 May;63(5):1714-24 [12675847] Am J Physiol Renal Physiol. 2003 Jul;285(1):F40-8 [12631553] Kidney Int. 2003 Aug;64(2):480-92 [12846743] Am J Kidney Dis. 2003 Sep;42(3):497-506 [12955677] Nephron Clin Pract. 2003;95(3):c91-9 [14646369] Mol Genet Metab. 2003 Dec;80(4):365-76 [14654349] Am J Physiol Renal Physiol. 2004 Jun;286(6):F1116-9 [14970000] J Am Soc Nephrol. 2004 Jul;15(7):1677-89 [15213255] Mol Cell Proteomics. 2006 Oct;5(10):1760-71 [16837576] Kidney Int. 2006 Nov;70(10):1847-57 [17021608] Nephrol Dial Transplant. 2007 Jan;22(1):295-6 [16951419] J Am Soc Nephrol. 2007 Feb;18(2):515-27 [17229913] Clin Sci (Lond). 2007 Jun;112(6):325-35 [17291194] Transl Res. 2007 May;149(5):237-42 [17466922] Am J Physiol Renal Physiol. 2007 May;292(5):F1657-61 [17229675] Nephron Clin Pract. 2007;106(2):c61-6 [17570931] Kidney Int. 2007 Aug;72(3):337-47 [17457373] Nat Clin Pract Nephrol. 2007 Aug;3(8):439-42 [17653122] Clin J Am Soc Nephrol. 2007 May;2(3):529-42 [17699461] Crit Care. 2007;11(2):R31 [17331245] J Am Soc Nephrol. 2008 Feb;19(2):217-24 [18235102] Pediatr Nephrol. 2008 Dec;23(12):2151-7 [17394022] Nephrol Dial Transplant. 2006 Jun;21(6):1534-40 [16449281] Am J Physiol Renal Physiol. 2006 May;290(5):F1187-93 [16368740] Kidney Int. 2006 Apr;69(8):1471-6 [16501490] Kidney Int. 2006 Apr;69(8):1302-7 [16531988] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/ki.2008.206 ER - TY - JOUR T1 - Drinking water disinfection by-product exposure and fetal growth. AN - 69427569; 18633330 AB - Previous studies suggest that elevated exposure to drinking water disinfection by-products (DBPs)--in particular, total trihalomethanes (TTHMs)--may lead to fetal growth restriction. We examined the effects of exposure to TTHMs, haloacetic acids, and total organic halide on the probability of delivering a small-for-gestational-age (SGA) infant and on birth weight at term. Women early in pregnancy (< or =12 weeks' gestation) or planning a pregnancy were enrolled in a prospective pregnancy study conducted in 3 US communities from 2000 through 2004. Weekly (or biweekly) water samples were collected at each site as well as individual-level participant data. Associations between DBP exposures (TTHMs, haloacetic acids, total organic halide) and fetal growth were assessed using log-binomial regression for SGA (n = 1958) and linear regression for term birth weight (n = 1854). We conducted a Bayesian analysis to examine associations between individual DBP species and fetal growth. Haloacetic acids and total organic halide were not associated with SGA or term birth weight. The probability of delivering an SGA infant was elevated when comparing women with an average third-trimester residential TTHM concentration > or =80 microg/L to women with exposure <80 microg/L (risk ratio = 2.0 [95% confidence interval = 1.1-3.6]), but not when examining other exposure contrasts. Bayesian analyses did not support a consistent association between any DBP species and fetal growth, although these analyses were based on small sample sizes. Our results do not suggest an adverse effect of haloacetic acid or total organic halide exposure on fetal growth. An association of TTHM with SGA was seen only for average residential concentrations above the current regulatory standard. JF - Epidemiology (Cambridge, Mass.) AU - Hoffman, Caroline S AU - Mendola, Pauline AU - Savitz, David A AU - Herring, Amy H AU - Loomis, Dana AU - Hartmann, Katherine E AU - Singer, Philip C AU - Weinberg, Howard S AU - Olshan, Andrew F AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. dilworthch@niehs.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 729 EP - 737 VL - 19 IS - 5 KW - Hydrocarbons, Halogenated KW - 0 KW - Index Medicus KW - Water Supply -- analysis KW - Humans KW - Adult KW - Infant, Newborn KW - Bayes Theorem KW - Male KW - Female KW - Pregnancy KW - Hydrocarbons, Halogenated -- analysis KW - Birth Weight -- drug effects KW - Fetal Growth Retardation -- chemically induced KW - Water Purification -- methods KW - Hydrocarbons, Halogenated -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69427569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Drinking+water+disinfection+by-product+exposure+and+fetal+growth.&rft.au=Hoffman%2C+Caroline+S%3BMendola%2C+Pauline%3BSavitz%2C+David+A%3BHerring%2C+Amy+H%3BLoomis%2C+Dana%3BHartmann%2C+Katherine+E%3BSinger%2C+Philip+C%3BWeinberg%2C+Howard+S%3BOlshan%2C+Andrew+F&rft.aulast=Hoffman&rft.aufirst=Caroline&rft.date=2008-09-01&rft.volume=19&rft.issue=5&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=1531-5487&rft_id=info:doi/10.1097%2FEDE.0b013e3181812bd4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/EDE.0b013e3181812bd4 ER - TY - JOUR T1 - Small-molecule inhibitor which reactivates p53 in human T-cell leukemia virus type 1-transformed cells. AN - 69426525; 18550670 AB - Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of the aggressive and fatal disease adult T-cell leukemia. Previous studies have demonstrated that the HTLV-1-encoded Tax protein inhibits the function of tumor suppressor p53 through a Tax-induced NF-kappaB pathway. Given these attributes, we were interested in the activity of small-molecule inhibitor 9-aminoacridine (9AA), an anticancer drug that targets two important stress response pathways, NF-kappaB and p53. In the present study, we have examined the effects of 9AA on HTLV-1-transformed cells. Treatment of HTLV-1-transformed cells with 9AA resulted in a dramatic decrease in cell viability. Consistent with these results, we observed an increase in the percentage of cells in sub-G(1) and an increase in the number of cells positive by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling assay following treatment of HTLV-1-transformed cells with 9AA. In each assay, HTLV-1-transformed cells C8166, Hut102, and MT2 were more sensitive to treatment with 9AA than control CEM and peripheral blood mononuclear cells. Analyzing p53 function, we demonstrate that treatment of HTLV-1-transformed cells with 9AA resulted in an increase in p53 protein and activation of p53 transcription activity. Of significance, 9AA-induced cell death could be blocked by introduction of a p53 small interfering RNA, linking p53 activity and cell death. These results suggest that Tax-repressed p53 function in HTLV-1-transformed cells is "druggable" and can be restored by treatment with 9AA. The fact that 9AA induces p53 and inhibits NF-kappaB suggests a promising strategy for the treatment of HTLV-1-transformed cells. JF - Journal of virology AU - Jung, Kyung-Jin AU - Dasgupta, Arindam AU - Huang, Keven AU - Jeong, Soo-Jin AU - Pise-Masison, Cynthia AU - Gurova, Katerina V AU - Brady, John N AD - Virus Tumor Biology Section, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 8537 EP - 8547 VL - 82 IS - 17 KW - Anticarcinogenic Agents KW - 0 KW - NF-kappa B KW - RNA, Small Interfering KW - Tumor Suppressor Protein p53 KW - Aminacrine KW - 78OY3Z0P7Z KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - Transcription, Genetic -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Luciferases -- metabolism KW - Plasmids KW - Cell Death -- drug effects KW - RNA, Small Interfering -- metabolism KW - In Situ Nick-End Labeling -- methods KW - Cell Survival -- drug effects KW - Transfection KW - Apoptosis -- drug effects KW - Genes, Reporter KW - G1 Phase -- drug effects KW - Cell Line, Transformed KW - Time Factors KW - Cell Cycle -- drug effects KW - Cell Transformation, Viral KW - NF-kappa B -- antagonists & inhibitors KW - Human T-lymphotropic virus 1 -- physiology KW - Tumor Suppressor Protein p53 -- biosynthesis KW - Anticarcinogenic Agents -- pharmacology KW - Aminacrine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69426525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Small-molecule+inhibitor+which+reactivates+p53+in+human+T-cell+leukemia+virus+type+1-transformed+cells.&rft.au=Jung%2C+Kyung-Jin%3BDasgupta%2C+Arindam%3BHuang%2C+Keven%3BJeong%2C+Soo-Jin%3BPise-Masison%2C+Cynthia%3BGurova%2C+Katerina+V%3BBrady%2C+John+N&rft.aulast=Jung&rft.aufirst=Kyung-Jin&rft.date=2008-09-01&rft.volume=82&rft.issue=17&rft.spage=8537&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00690-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-08-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Cancer. 2002 Aug;2(8):594-604 [12154352] J Biol Chem. 2001 Jan 5;276(1):200-5 [11036071] J Biol Chem. 2003 Jan 10;278(2):919-26 [12419817] Carcinogenesis. 2003 Mar;24(3):377-84 [12663495] J Biol Chem. 2004 Apr 30;279(18):18137-45 [14963024] J Biol Chem. 2004 Jul 30;279(31):31991-4 [15090550] Blood. 2004 Sep 1;104(5):1490-7 [15155458] Front Biosci. 2004 Sep 1;9:2347-72 [15353292] Oral Surg Oral Med Oral Pathol. 1968 Oct;26(4):560-2 [5244782] Science. 1987 Sep 11;237(4820):1324-9 [2888190] Science. 1987 Sep 11;237(4820):1340-3 [2888191] Proc Natl Acad Sci U S A. 1989 May;86(9):3351-5 [2541443] Jpn J Cancer Res. 1989 Mar;80(3):191-5 [2498254] J Enzyme Inhib. 1987;1(4):275-87 [3508914] Mol Cell Biol. 1990 Jan;10(1):413-7 [2403646] Proc Natl Acad Sci U S A. 1990 Feb;87(3):1071-5 [2300570] Mol Cell Biol. 1991 Oct;11(10):5222-8 [1922042] Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1057-61 [7862633] Blood. 1995 Dec 1;86(11):4243-9 [7492783] J Virol. 1998 Mar;72(3):2554-9 [9499124] Methods. 1998 Sep;16(1):83-94 [9774518] J Pathol. 1999 Jan;187(1):112-26 [10341712] Mol Cell Biol. 1999 Jul;19(7):4798-805 [10373529] Nature. 1999 Sep 2;401(6748):82-5 [10485710] Nature. 1999 Sep 2;401(6748):86-90 [10485711] J Biol Chem. 1999 Oct 22;274(43):30353-6 [10521409] Genes Dev. 1999 Nov 15;13(22):2905-27 [10579998] Mol Cell Biol. 2000 May;20(10):3377-86 [10779327] AIDS Res Hum Retroviruses. 2000 Nov 1;16(16):1647-51 [11080805] AIDS Res Hum Retroviruses. 2000 Nov 1;16(16):1695-700 [11080812] Nature. 2000 Nov 16;408(6810):307-10 [11099028] J Antimicrob Chemother. 2001 Jan;47(1):1-13 [11152426] J Clin Invest. 2001 Jan;107(2):143-51 [11160127] Annu Rev Immunol. 2001;19:475-96 [11244044] Cytokine Growth Factor Rev. 2001 Jun-Sep;12(2-3):207-17 [11325603] J Biol Chem. 2001 Jun 1;276(22):18934-40 [11259436] Trends Mol Med. 2002 Aug;8(8):385-9 [12127724] Front Biosci. 2005 Jan 1;10:919-30 [15569630] Arch Immunol Ther Exp (Warsz). 2005 Jul-Aug;53(4):283-96 [16088313] Oncogene. 2005 Sep 5;24(39):6035-46 [16155610] Oncogene. 2005 Oct 6;24(44):6719-28 [16007163] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17448-53 [16287968] Retrovirology. 2005;2:75 [16336683] J Biol Chem. 2006 Mar 31;281(13):8927-38 [16436385] Nat Med. 2006 Apr;12(4):466-72 [16550188] Blood. 2006 Aug 1;108(3):1021-9 [16569765] Virology. 2008 Jan 20;370(2):264-72 [17931677] Virol J. 2008;5:41 [18348731] Trends Biochem Sci. 2002 Sep;27(9):462-7 [12217521] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00690-08 ER - TY - JOUR T1 - Botanicals used in complementary and alternative medicine treatment of cancer: clinical science and future perspectives. AN - 69416846; 18694368 AB - Botanicals and herbal combinations are among the most common complementary and alternative medicine (CAM) approaches used by cancer patients both for cancer treatment and management of cancer symptoms. Despite their widespread use, however, the safety and efficacy of many botanicals has not been established in controlled clinical trials. This article reviews the published evidence for the safety and clinical benefit of botanicals used in the treatment of cancer and cancer symptom management and describes the continuing clinical trials of botanicals with applications in oncology. Literature searches were conducted in PubMed, EMBASE, Cochrane Clinical Trials databases, Pharmaprojects and CRISP (Computer Retrieval of Information on Scientific Projects) clinical trials databases. A number of botanicals have shown promise for cancer symptom management but need further study. A limited number of multi-agent nutritional supplement approaches are being explored in clinical trials. Botanical immunomodulators and botanical products shown to affect pathways of angiogenesis, apoptosis and cell signaling in vitro have stimulated research interest and may broaden the range of available cancer treatments. JF - Expert opinion on investigational drugs AU - Miller, Scott AU - Stagl, Jamie AU - Wallerstedt, Dawn B AU - Ryan, Mary AU - Mansky, Patrick J AD - National Center for Complementary and Alternative Medicine, National Institutes of Health, DHHS, 10 Center Drive, Bethesda, MD 20892-1302, USA. Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 1353 EP - 1364 VL - 17 IS - 9 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Santalaceae -- chemistry KW - Animals KW - Agaricales -- chemistry KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Antineoplastic Agents -- therapeutic use KW - Phytotherapy KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69416846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+investigational+drugs&rft.atitle=Botanicals+used+in+complementary+and+alternative+medicine+treatment+of+cancer%3A+clinical+science+and+future+perspectives.&rft.au=Miller%2C+Scott%3BStagl%2C+Jamie%3BWallerstedt%2C+Dawn+B%3BRyan%2C+Mary%3BMansky%2C+Patrick+J&rft.aulast=Miller&rft.aufirst=Scott&rft.date=2008-09-01&rft.volume=17&rft.issue=9&rft.spage=1353&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+investigational+drugs&rft.issn=1744-7658&rft_id=info:doi/10.1517%2F13543784.17.9.1353 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-12 N1 - Date created - 2008-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/13543784.17.9.1353 ER - TY - JOUR T1 - Effects of (-)-epigallocatechin gallate on the redox reactions of human hemoglobin. AN - 69413039; 18539156 AB - The toxicity of acellular hemoglobin (Hb)-based therapeutics has been attributed in part to the uncontrolled oxidative reactions. A variety of antioxidant strategies to ameliorate potential oxidative damage in vivo have been suggested. We have examined the effects of (-)-epigallocatechin gallate (EGCG), a green tea polyphenol compound widely regarded as a chain-breaking antioxidant, on the oxidative stability of diaspirin crosslinked Hb (DBBF) and its cytotoxic ferryl intermediate. DBBF (ferrous) was rapidly oxidized to the ferric form in the presence of EGCG relative to the normal spontaneous oxidation of this Hb. The fast elimination of ferrous Hb is probably due to the ability of EGCG to produce hydrogen peroxide (H2O2) as these reactions were almost completely reversed by the addition of catalase and superoxide dismutase to the reaction medium. EGCG, however, effectively reduced ferryl back to ferric Hb in a biphasic kinetic reaction at physiological pH. At acidic pH where the autoreduction of protonated ferryl Hb is enhanced, a monophasic reduction process of the ferryl heme is achieved. A balance between pro and antioxidant properties of EGCG should be taken into account if EGCG is used in combination therapy with redox active acellular Hbs. JF - Free radical biology & medicine AU - Jia, Yiping AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health Campus, Bethesda, MD 20892, USA. yiping.jia@fda.hhs.gov Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 659 EP - 666 VL - 45 IS - 5 SN - 0891-5849, 0891-5849 KW - Cross-Linking Reagents KW - 0 KW - Hemoglobins KW - succinyldisalicylic acid KW - 578-19-8 KW - Catechin KW - 8R1V1STN48 KW - epigallocatechin gallate KW - BQM438CTEL KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Cross-Linking Reagents -- chemistry KW - Oxidation-Reduction -- drug effects KW - Aspirin -- chemistry KW - Humans KW - Aspirin -- analogs & derivatives KW - Hemoglobins -- metabolism KW - Catechin -- analogs & derivatives KW - Hemoglobins -- chemistry KW - Catechin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69413039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Effects+of+%28-%29-epigallocatechin+gallate+on+the+redox+reactions+of+human+hemoglobin.&rft.au=Jia%2C+Yiping%3BAlayash%2C+Abdu+I&rft.aulast=Jia&rft.aufirst=Yiping&rft.date=2008-09-01&rft.volume=45&rft.issue=5&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.05.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.05.010 ER - TY - JOUR T1 - Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. AN - 69412880; 18572023 AB - Arsenic is a well-known human skin carcinogen but the underlying mechanisms of carcinogenesis are unclear. Transcription factor Nrf2-mediated antioxidant response represents a critical cellular defense mechanism, and emerging data suggest that constitutive activation of Nrf2 contributes to malignant phenotype. In the present study when an immortalized, nontumorigenic human keratinocyte cell line (HaCaT) was continuously exposed to an environmentally relevant level of inorganic arsenite (100 nM) for 28 weeks, malignant transformation occurred as evidenced by the formation of highly aggressive squamous cell carcinoma after inoculation into nude mice. To investigate the mechanisms involved, a broad array of biomarkers for transformation were assessed in these arsenic-transformed cells (termed As-TM). In addition to increased secretion of matrix metalloproteinase-9 (MMP-9), a set of markers for squamous differentiation and skin keratinization, including keratin-1, keratin-10, involucrin, and loricrin, were significantly elevated in As-TM cells. Furthermore, As-TM cells showed increased intracellular glutathione and elevated expression of Nrf2 and its target genes, as well as generalized apoptotic resistance. In contrast to increased basal Nrf2 activity in As-TM cells, a diminished Nrf2-mediated antioxidant response induced by acute exposure to high doses of arsenite or tert-butyl hydroxyquinone occurred. The findings that multiple biomarkers for malignant transformation observed in As-TM cells, including MMP-9 and cytokeratins, are potentially regulated by Nrf2 suggest that constitutive Nrf2 activation may be involved in arsenic carcinogenesis of skin. The weakened Nrf2 activation in response to oxidative stressors observed in As-TM cells, coupled with acquired apoptotic resistance, would potentially have increased the likelihood of transmittable oxidative DNA damage and fixation of mutational/DNA damage events. JF - Free radical biology & medicine AU - Pi, Jingbo AU - Diwan, Bhalchandra A AU - Sun, Yang AU - Liu, Jie AU - Qu, Wei AU - He, Yuying AU - Styblo, Miroslav AU - Waalkes, Michael P AD - Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA. jpi@thehamner.org Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 651 EP - 658 VL - 45 IS - 5 SN - 0891-5849, 0891-5849 KW - Arsenites KW - 0 KW - NF-E2-Related Factor 2 KW - NFE2L2 protein, human KW - Casein Kinase II KW - EC 2.7.11.1 KW - arsenite KW - N5509X556J KW - Index Medicus KW - Casein Kinase II -- metabolism KW - Cell Nucleus -- metabolism KW - Humans KW - Apoptosis -- radiation effects KW - Cell Line KW - Arsenites -- pharmacology KW - Cell Transformation, Neoplastic -- pathology KW - Keratinocytes -- drug effects KW - Cell Transformation, Neoplastic -- metabolism KW - Cell Transformation, Neoplastic -- chemically induced KW - Keratinocytes -- metabolism KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69412880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Arsenic-induced+malignant+transformation+of+human+keratinocytes%3A+involvement+of+Nrf2.&rft.au=Pi%2C+Jingbo%3BDiwan%2C+Bhalchandra+A%3BSun%2C+Yang%3BLiu%2C+Jie%3BQu%2C+Wei%3BHe%2C+Yuying%3BStyblo%2C+Miroslav%3BWaalkes%2C+Michael+P&rft.aulast=Pi&rft.aufirst=Jingbo&rft.date=2008-09-01&rft.volume=45&rft.issue=5&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.05.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2002 Dec 1;62(23):6973-80 [12460915] Toxicol Appl Pharmacol. 2008 Feb 1;226(3):236-43 [17980396] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5 [11248092] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6 [11287661] Free Radic Biol Med. 2001 Jun 1;30(11):1191-212 [11368918] Toxicol Appl Pharmacol. 2001 Oct 1;176(1):64-71 [11578149] Environ Health Perspect. 2002 Apr;110(4):331-6 [11940449] Trends Cell Biol. 2002 May;12(5):226-30 [12062170] Mol Cell Biochem. 2002 May-Jun;234-235(1-2):301-8 [12162448] Br J Dermatol. 2002 Sep;147(3):498-502 [12207590] J Cell Sci. 2002 Oct 15;115(Pt 20):3873-8 [12244125] Apoptosis. 2003 Aug;8(4):315-25 [12815274] Exp Cell Res. 2003 Nov 1;290(2):234-45 [14567983] Nat Genet. 2003 Nov;35(3):238-45 [14517554] Carcinogenesis. 2004 Jan;25(1):133-41 [14514661] Toxicol Sci. 2004 May;79(1):56-63 [14976345] Chem Res Toxicol. 2004 Jul;17(7):871-8 [15257611] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):291-6 [15276408] Free Radic Biol Med. 2004 Sep 1;37(5):574-81 [15288115] Free Radic Biol Med. 2004 Sep 1;37(5):582-93 [15288116] Cell Biol Int Rep. 1981 Feb;5(2):143-50 [7194742] J Invest Dermatol. 1984 May;82(5):449-52 [6210326] Oral Surg Oral Med Oral Pathol. 1986 Aug;62(2):155-63 [2427985] J Cell Biol. 1988 Mar;106(3):761-71 [2450098] Eur J Biochem. 1990 Apr 30;189(2):251-7 [2159876] Proc Natl Acad Sci U S A. 1994 May 10;91(10):4293-7 [8183903] Science. 1995 Feb 10;267(5199):894-7 [7846532] Physiol Rev. 1997 Apr;77(2):397-424 [9114819] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] J Am Acad Dermatol. 1998 Feb;38(2 Pt 1):179-85 [9486671] Hum Pathol. 1998 Sep;29(9):965-71 [9744313] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] Environ Health Perspect. 2004 Dec;112(17):1704-10 [15579417] Cancer Res. 2005 May 15;65(10):4362-7 [15899828] Int J Cancer. 2005 Aug 10;116(1):20-6 [15756686] J Occup Health. 2005 Sep;47(5):445-9 [16230839] Mol Cell Biochem. 2005 Nov;279(1-2):105-12 [16283519] Cell. 2000 Jan 7;100(1):57-70 [10647931] Free Radic Biol Med. 2000 Apr 1;28(7):1137-42 [10832076] Biol Chem. 2000 May-Jun;381(5-6):497-507 [10937882] Mol Cell. 2006 Mar 3;21(5):689-700 [16507366] Head Neck. 2006 Sep;28(9):813-8 [16637057] Adv Enzyme Regul. 2006;46:113-40 [16887173] PLoS Med. 2006 Oct;3(10):e420 [17020408] Mutat Res. 2007 Feb 3;615(1-2):75-86 [17134727] Hum Mol Genet. 2007 May 15;16(10):1188-200 [17409198] Free Radic Biol Med. 2007 Jun 15;42(12):1797-806 [17512459] Mol Med. 2008 Jan-Feb;14(1-2):2-10 [18037969] J Natl Cancer Inst. 2002 Dec 18;94(24):1888-91 [12488483] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.05.020 ER - TY - JOUR T1 - Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. AN - 69411895; 18503778 AB - The chemical reactivity, toxicology, and pharmacological responses to nitroxyl (HNO) are often distinctly different from those of nitric oxide (NO). The discovery that HNO donors may have pharmacological utility for treatment of cardiovascular disorders such as heart failure and ischemia reperfusion has led to increased speculation of potential endogenous pathways for HNO biosynthesis. Here, the ability of heme proteins to utilize H2O2 to oxidize hydroxylamine (NH2OH) or N-hydroxy-L-arginine (NOHA) to HNO was examined. Formation of HNO was evaluated with a recently developed selective assay in which the reaction products in the presence of reduced glutathione (GSH) were quantified by HPLC. Release of HNO from the heme pocket was indicated by formation of sulfinamide (GS(O)NH2), while the yields of nitrite and nitrate signified the degree of intramolecular recombination of HNO with the heme. Formation of GS(O)NH2 was observed upon oxidation of NH2OH, whereas NOHA, the primary intermediate in oxidation of L-arginine by NO synthase, was apparently resistant to oxidation by the heme proteins utilized. In the presence of NH2OH, the highest yields of GS(O)NH2 were observed with proteins in which the heme was coordinated to a histidine (horseradish peroxidase, lactoperoxidase, myeloperoxidase, myoglobin, and hemoglobin) in contrast to a tyrosine (catalase) or cysteine (cytochrome P450). That peroxidation of NH2OH by horseradish peroxidase produced free HNO, which was able to affect intracellular targets, was verified by conversion of 4,5-diaminofluorescein to the corresponding fluorophore within intact cells. JF - Free radical biology & medicine AU - Donzelli, Sonia AU - Espey, Michael Graham AU - Flores-Santana, Wilmarie AU - Switzer, Christopher H AU - Yeh, Grace C AU - Huang, Jinming AU - Stuehr, Dennis J AU - King, S Bruce AU - Miranda, Katrina M AU - Wink, David A AD - Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. sdonzell@uke.uni-hamburg.de Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 578 EP - 584 VL - 45 IS - 5 SN - 0891-5849, 0891-5849 KW - Hemeproteins KW - 0 KW - Nitrogen Oxides KW - Peroxides KW - Hydroxylamine KW - 2FP81O2L9Z KW - N(5)-hydroxy-L-arginine KW - 42599-90-6 KW - Arginine KW - 94ZLA3W45F KW - Glutathione KW - GAN16C9B8O KW - nitroxyl KW - GFQ4MMS07W KW - Index Medicus KW - Arginine -- metabolism KW - Humans KW - Glutathione -- metabolism KW - Electron Spin Resonance Spectroscopy KW - Cell Line, Tumor KW - Arginine -- analogs & derivatives KW - Peroxides -- metabolism KW - Hydroxylamine -- metabolism KW - Hemeproteins -- metabolism KW - Nitrogen Oxides -- metabolism KW - Nitrogen Oxides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69411895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Generation+of+nitroxyl+by+heme+protein-mediated+peroxidation+of+hydroxylamine+but+not+N-hydroxy-L-arginine.&rft.au=Donzelli%2C+Sonia%3BEspey%2C+Michael+Graham%3BFlores-Santana%2C+Wilmarie%3BSwitzer%2C+Christopher+H%3BYeh%2C+Grace+C%3BHuang%2C+Jinming%3BStuehr%2C+Dennis+J%3BKing%2C+S+Bruce%3BMiranda%2C+Katrina+M%3BWink%2C+David+A&rft.aulast=Donzelli&rft.aufirst=Sonia&rft.date=2008-09-01&rft.volume=45&rft.issue=5&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.04.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2264-76 [12855429] Cell Calcium. 2005 Jan;37(1):87-96 [15541467] Eur J Pharmacol. 2001 Nov 2;430(2-3):311-5 [11711049] Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364(6):516-23 [11770006] Chem Rev. 2002 Apr;102(4):993-1018 [11942785] Proc Natl Acad Sci U S A. 2002 May 28;99(11):7340-5 [12032284] Arch Biochem Biophys. 2002 May 15;401(2):134-44 [12054463] Free Radic Biol Med. 2002 Sep 15;33(6):827-34 [12208370] J Biol Chem. 2002 Oct 25;277(43):40666-74 [12194971] Free Radic Biol Med. 2003 Jan 1;34(1):33-43 [12498977] Arch Biochem Biophys. 2003 Feb 1;410(1):89-95 [12559980] Curr Med Chem. 2003 Mar;10(6):437-52 [12570692] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):4978-80 [12704227] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5537-42 [12704230] Free Radic Biol Med. 2003 Jun 1;34(11):1399-404 [12757850] Hypertension. 2003 Jun;41(6):1301-7 [12743008] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9196-201 [12865500] Biochem Biophys Res Commun. 1984 Jul 18;122(1):358-65 [6378202] J Med Chem. 1990 Dec;33(12):3120-2 [2258896] J Biol Chem. 1991 Apr 5;266(10):6259-63 [1706713] Biochem Biophys Res Commun. 1991 Apr 15;176(1):528-34 [2018542] Biochem Pharmacol. 1992 Feb 4;43(3):607-13 [1540216] J Pharmacol Exp Ther. 1992 Nov;263(2):546-51 [1331403] FASEB J. 1993 Feb 1;7(2):349-60 [8440411] J Med Chem. 1993 Sep 3;36(18):2666-70 [7692046] Circulation. 1994 May;89(5):2070-8 [7910117] Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10992-6 [7526387] Biochemistry. 1995 Feb 14;34(6):1930-41 [7531495] Arch Biochem Biophys. 1995 Apr 20;318(2):279-85 [7733655] FEBS Lett. 1996 Mar 18;382(3):223-8 [8605974] Free Radic Biol Med. 1996;21(1):35-41 [8791091] J Med Chem. 1996 Oct 25;39(22):4361-5 [8893830] Am J Physiol. 1996 Nov;271(5 Pt 2):H1988-98 [8945918] Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14492-7 [8962079] Biochemistry. 1997 Nov 25;36(47):14465-73 [9398165] Free Radic Biol Med. 1998 Jan 1;24(1):66-75 [9436615] Biochim Biophys Acta. 1998 Mar 12;1380(1):64-74 [9545536] Neuron. 1999 Oct;24(2):461-9 [10571239] Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14617-22 [10588754] Biochem Pharmacol. 2000 Jun 15;59(12):1603-9 [10799659] J Biol Chem. 2000 Oct 27;275(43):33554-61 [10945985] J Biol Chem. 2001 Jan 19;276(3):1720-7 [11042174] J Biol Chem. 2001 Aug 10;276(32):30085-91 [11404354] Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10463-8 [11517312] J Neurochem. 2001 Sep;78(5):1126-34 [11553686] Biochemistry. 2001 Sep 25;40(38):11533-42 [11560502] Biochemistry. 1998 Apr 21;37(16):5362-71 [9548918] Clin Pharmacokinet. 1998 May;34(5):347-58 [9592619] Eur J Pharmacol. 1998 May 15;349(1):53-60 [9669496] Biochem Pharmacol. 1998 Jun 15;55(12):2007-15 [9714321] Biochemistry. 1998 Nov 3;37(44):15503-12 [9799513] Can Med Assoc J. 1956 May 15;74(10):793-5 [13316669] J Am Chem Soc. 2005 Jan 19;127(2):722-31 [15643898] Circ Res. 2005 Feb 4;96(2):234-43 [15591228] Annu Rev Pharmacol Toxicol. 2005;45:335-55 [15822180] Curr Top Med Chem. 2005;5(7):665-73 [16101427] Free Radic Biol Med. 2005 Dec 1;39(11):1478-88 [16274883] Curr Med Chem. 2005;12(23):2741-51 [16305469] J Med Chem. 2005 Dec 29;48(26):8220-8 [16366603] Free Radic Biol Med. 2006 Mar 15;40(6):1056-66 [16540401] Free Radic Biol Med. 2006 Nov 15;41(10):1606-18 [17045928] Circ Res. 2007 Jan 5;100(1):96-104 [17138943] J Cyclic Nucleotide Res. 1977 Feb;3(1):23-35 [14978] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.04.036 ER - TY - JOUR T1 - Molecular mechanisms for discrete nitric oxide levels in cancer. AN - 69324202; 18472020 AB - Nitric oxide (NO) has been invoked in nearly every normal and pathological condition associated with human physiology. In tumor biology, nitrogen oxides have both positive and negative affects as they have been implicated in both promoting and preventing cancer. Our work has focused on NO chemistry and how it correlates with cytotoxicity and cancer. Toward this end, we have studied both concentration- and time-dependent NO regulation of specific signaling pathways in response to defined nitrosative stress levels that may occur within the tumor microenvironment. Threshold levels of NO required for activation and stabilization of key proteins involved in carcinogenesis including p53, ERK, Akt and HIF have been identified. Importantly, threshold NO levels are further influenced by reactive oxygen species (ROS) including superoxide, which can shift or attenuate NO-mediated signaling as observed in both tumor and endothelial cells. Our studies have been extended to determine levels of NO that are critical during angiogenic response through regulation of the anti-angiogenic agent thrombospondin-1 (TSP-1) and pro-angiogenic agent matrix metalloproteinase-9 (MMP-9). The quantification of redox events at the cellular level has revealed potential mechanisms that may either limit or potentiate tumor growth, and helped define the positive and negative function of nitric oxide in cancer. JF - Nitric oxide : biology and chemistry AU - Ridnour, Lisa A AU - Thomas, Douglas D AU - Switzer, Christopher AU - Flores-Santana, Wilmarie AU - Isenberg, Jeffrey S AU - Ambs, Stefan AU - Roberts, David D AU - Wink, David A AD - Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Bethesda, MD 20892, USA. ridnourl@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 73 EP - 76 VL - 19 IS - 2 KW - Reactive Nitrogen Species KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Humans KW - Neovascularization, Pathologic KW - Inflammation KW - Neoplasms -- pathology KW - Nitric Oxide -- metabolism KW - Nitric Oxide -- physiology KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69324202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nitric+oxide+%3A+biology+and+chemistry&rft.atitle=Molecular+mechanisms+for+discrete+nitric+oxide+levels+in+cancer.&rft.au=Ridnour%2C+Lisa+A%3BThomas%2C+Douglas+D%3BSwitzer%2C+Christopher%3BFlores-Santana%2C+Wilmarie%3BIsenberg%2C+Jeffrey+S%3BAmbs%2C+Stefan%3BRoberts%2C+David+D%3BWink%2C+David+A&rft.aulast=Ridnour&rft.aufirst=Lisa&rft.date=2008-09-01&rft.volume=19&rft.issue=2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Nitric+oxide+%3A+biology+and+chemistry&rft.issn=1089-8611&rft_id=info:doi/10.1016%2Fj.niox.2008.04.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-17 N1 - Date created - 2008-07-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Apr 14;275(15):11341-7 [10753947] Blood. 2008 Jan 15;111(2):613-23 [17890448] Nat Med. 2001 Sep;7(9):1048-51 [11533709] J Leukoc Biol. 2001 Oct;70(4):478-90 [11590184] Nitric Oxide. 2002 Aug;7(1):1-10 [12175813] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):143-8 [12518062] Clin Sci (Lond). 2003 Jan;104(1):27-38 [12519085] J Biol Chem. 2003 Jul 18;278(29):26480-7 [12740377] Chem Res Toxicol. 2003 Aug;16(8):1004-13 [12924928] Mol Biol Cell. 2003 Aug;14(8):3470-81 [12925778] Cancer Res. 2003 Dec 15;63(24):8853-60 [14695202] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8894-9 [15178764] Cancer Res. 2004 Oct 1;64(19):6849-53 [15466171] J Exp Med. 1989 May 1;169(5):1543-55 [2497225] Lancet. 1990 Dec 15;336(8729):1489-92 [1979101] Res Immunol. 1991 Sep;142(7):565-9; discussion 596-8 [1812549] Free Radic Biol Med. 1998 Sep;25(4-5):434-56 [9741580] Cancer Res. 1999 May 1;59(9):2142-9 [10232601] Curr Mol Med. 2004 Nov;4(7):741-51 [15579021] Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13147-52 [16141331] Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13141-6 [16150726] Eur J Cancer. 2005 Dec;41(18):2792-805 [16290133] Int J Cancer. 2006 Aug 15;119(4):861-6 [16557582] Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1329-37 [16910780] J Biol Chem. 2006 Sep 8;281(36):25984-93 [16829532] J Biol Chem. 2006 Sep 8;281(36):26069-80 [16835222] Int J Cancer. 2007 Feb 15;120(4):796-805 [17096325] Cancer Res. 2007 Jan 1;67(1):289-99 [17210710] Am J Respir Cell Mol Biol. 2007 Feb;36(2):138-46 [16980554] Clin Cancer Res. 2007 Feb 1;13(3):795-8 [17289869] Mol Cell. 2007 Apr 13;26(1):63-74 [17434127] Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15478-83 [17875988] Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16898-903 [17942699] Clin Cancer Res. 2000 Dec;6(12):4768-75 [11156233] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.niox.2008.04.006 ER - TY - JOUR T1 - Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A. AN - 66664771; 19172746 AB - Plasmodium falciparum-infected erythrocytes bind to chondroitin sulfate A (CSA) in the placenta via the VAR2CSA protein, a member of the P. falciparum erythrocyte membrane protein-1 family, leading to life-threatening malaria in pregnant women with severe effects on their fetuses and newborns. Here we describe the structure of the CSA binding DBL3x domain, a Duffy binding-like (DBL) domain of VAR2CSA. By forming a complex of DBL3x with CSA oligosaccharides and determining its structure, we have identified the CSA binding site to be a cluster of conserved positively charged residues on subdomain 2 and subdomain 3. Mutation or chemical modification of lysine residues at the site markedly diminished CSA binding to DBL3x. The location of the CSA binding site is an important step forward in the molecular understanding of pregnancy-associated malaria and offers a new target for vaccine development. JF - Nature structural & molecular biology AU - Singh, Kavita AU - Gittis, Apostolos G AU - Nguyen, Phuc AU - Gowda, D Channe AU - Miller, Louis H AU - Garboczi, David N AD - Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852, USA. ksingh@niaid.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 932 EP - 938 VL - 15 IS - 9 SN - 1545-9993, 1545-9993 KW - Antigens, Protozoan KW - 0 KW - Macromolecular Substances KW - Protozoan Proteins KW - VAR2CSA protein, Plasmodium falciparum KW - Chondroitin Sulfates KW - 9007-28-7 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Humans KW - Infant, Newborn KW - Malaria, Falciparum -- complications KW - Pregnancy KW - Binding Sites KW - Static Electricity KW - Mutagenesis, Site-Directed KW - Erythrocytes -- chemistry KW - Erythrocytes -- parasitology KW - Placenta -- parasitology KW - Malaria, Falciparum -- parasitology KW - Crystallography, X-Ray KW - Pregnancy Complications, Parasitic -- parasitology KW - Protein Structure, Tertiary KW - Macromolecular Substances -- chemistry KW - Female KW - Protozoan Proteins -- chemistry KW - Chondroitin Sulfates -- chemistry KW - Protozoan Proteins -- metabolism KW - Antigens, Protozoan -- genetics KW - Plasmodium falciparum -- genetics KW - Plasmodium falciparum -- pathogenicity KW - Protozoan Proteins -- genetics KW - Antigens, Protozoan -- metabolism KW - Plasmodium falciparum -- chemistry KW - Antigens, Protozoan -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66664771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+structural+%26+molecular+biology&rft.atitle=Structure+of+the+DBL3x+domain+of+pregnancy-associated+malaria+protein+VAR2CSA+complexed+with+chondroitin+sulfate+A.&rft.au=Singh%2C+Kavita%3BGittis%2C+Apostolos+G%3BNguyen%2C+Phuc%3BGowda%2C+D+Channe%3BMiller%2C+Louis+H%3BGarboczi%2C+David+N&rft.aulast=Singh&rft.aufirst=Kavita&rft.date=2008-09-01&rft.volume=15&rft.issue=9&rft.spage=932&rft.isbn=&rft.btitle=&rft.title=Nature+structural+%26+molecular+biology&rft.issn=15459993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2009-01-27 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3CPZ; PDB; 3CML N1 - SuppNotes - Cited By: J Biol Chem. 2008 Aug 8;283(32):21842-6 [18550531] J Biol Chem. 2008 Feb 15;283(7):3932-41 [18065761] J Biol Chem. 2000 Dec 22;275(51):40357-64 [11005815] Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2664-9 [11226296] Mol Microbiol. 2003 Jul;49(1):179-91 [12823820] Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):706-8 [15039560] Placenta. 2004 May;25(5):359-78 [15081631] Glycobiology. 2004 Jul;14(7):635-45 [15044390] Mol Microbiol. 2004 Jul;53(2):445-55 [15228526] J Mol Biol. 1978 Oct 15;125(1):1-19 [712855] J Exp Med. 1995 Jul 1;182(1):15-20 [7790815] Cell. 1995 Jul 14;82(1):101-10 [7606775] Cell. 1995 Jul 14;82(1):77-87 [7541722] Cell. 1995 Jul 14;82(1):89-100 [7606788] Science. 1996 Jun 7;272(5267):1502-4 [8633247] Methods Enzymol. 1997;276:171-9 [9048376] Nature. 1998 Oct 29;395(6705):851-2 [9804416] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2115-25 [15572764] J Infect Dis. 2005 Mar 15;191(6):1010-3 [15717280] Cell. 2005 Jul 29;122(2):183-93 [16051144] EMBO Rep. 2005 Aug;6(8):775-81 [16025132] Curr Top Microbiol Immunol. 2005;297:187-227 [16265906] Structure. 2006 Jan;14(1):33-42 [16407063] Nature. 2006 Feb 9;439(7077):741-4 [16372020] Exp Parasitol. 2006 May;113(1):36-42 [16430888] Mol Biochem Parasitol. 2006 Aug;148(2):117-24 [16631964] PLoS Pathog. 2006 Nov;2(11):e124 [17112315] Microbes Infect. 2006 Nov-Dec;8(14-15):2863-71 [17095277] Int J Parasitol. 2007 Mar;37(3-4):273-83 [17224156] Mol Biochem Parasitol. 2007 Sep;155(1):57-65 [17618698] Mol Biochem Parasitol. 2007 Oct;155(2):103-12 [17669514] Parasitology. 2007;134(Pt 13):1871-6 [17958922] Nat Protoc. 2007;2(11):2728-33 [18007608] J Biol Chem. 2000 Dec 22;275(51):40344-56 [11005814] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physical and Mental Comorbidity of Headache in a Nationally Representative Sample of US Adults AN - 57336777; 200900452 AB - Objective: To investigate the contribution of comorbidity to health utilization and negative health perception in a large-scale population-based study. Comorbidity of headache with physical and mental disorders has been reported frequently in clinical samples. Methods: This concern was addressed using combined 6-year data from the 1999 to 2004 National Health Examination and Nutrition Survey (n = 31,126 adults), nationally representative datasets of the US population. Measures of physical disorders were based on standardized interviews of chronic conditions, and mental disorders were assessed by the Composite International Diagnostic Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. Results: The 3-month prevalence of severe headaches or migraine in the US general population was 22.73%, with females and young adults having greater rates than males and older adults. Adults with headache had increased odds for a variety of physical disorders (including asthma, rheumatoid arthritis, and stroke) and mental disorders (including depression, generalized anxiety disorder, and panic disorder). Adults with headache were more likely to rate their health as "fair or poor" (17.9% versus 6.1%), to seek health care four or more times in a year (43.3% versus 22.7%), and to endorse physical and mental limitations. Health utilization and negative health perception were more strongly influenced by comorbid mental disorders than physical disorders. Conclusions: The results from this nationally representative sample provide new information on the interrelationships of headache with mental and physical disorders. The greater impact of comorbid mental compared with physical disorders on healthcare utilization and health perception has important implications for the clinical evaluation and treatment of headache in the population. Adapted from the source document. JF - Psychosomatic Medicine AU - Kalaydjian, Amanda AU - Merikangas, Kathleen AD - Intramural Research Program, National Institute of Mental Health, Section on Developmental Genetic Epidemiology, 35 Convent Drive, #1A-108, Bethesda, MD 20892 Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 773 EP - 780 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 70 IS - 7 SN - 0033-3174, 0033-3174 KW - headache, migraine, comorbidity, psychiatric, disability, epidemiology KW - Epidemiology KW - Migraine KW - Psychiatric disorders KW - Headaches KW - Disability KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57336777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Physical+and+Mental+Comorbidity+of+Headache+in+a+Nationally+Representative+Sample+of+US+Adults&rft.au=Kalaydjian%2C+Amanda%3BMerikangas%2C+Kathleen&rft.aulast=Kalaydjian&rft.aufirst=Amanda&rft.date=2008-09-01&rft.volume=70&rft.issue=7&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/10.1097%2FPSY.0b013e31817f9e80 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMEAP N1 - SubjectsTermNotLitGenreText - Headaches; Psychiatric disorders; Comorbidity; Migraine; Disability; Epidemiology DO - http://dx.doi.org/10.1097/PSY.0b013e31817f9e80 ER - TY - JOUR T1 - BRCA mutation-negative women from hereditary breast and ovarian cancer families: a qualitative study of the BRCA-negative experience AN - 57296781; 200913665 AB - Background When women from families with a known BRCA1 or BRCA2 mutation test negative for the family mutation, it is assumed that they will transition their personal cancer risk perception from high to average risk. However, there are scant data regarding the experience of mutation-negative women after genetic testing disclosure, particularly related to the shift of risk perception from assumed mutation-positive to actual mutation-negative. This study was designed to explore cancer risk perception and the experience of being a mutation-negative woman within a known BRCA1/2 mutation-positive family. Methods We employed a qualitative descriptive design and convened a sample of 13 women who contributed in-depth, semi-structured telephone interviews (audio-recorded and transcribed verbatim) and performed qualitative content analysis with NVivo 2.0 software. Results Six major content areas emerged from interview data: (i) rationale for initial involvement in the breast imaging study, (ii) rationale for continued participation, (iii) experience of living in a multiple-case family, (iv) risk perception: the personal meaning of mutation-negative status, (v) opinions regarding cancer aetiology and (vi) communication patterns between mutation-negative and mutation-positive family members. Conclusions Living in a hereditary breast and ovarian cancer family is a complex experience that affects cognitive, emotional and social functioning. Our findings indicate that mutation-negative women may have unmet psychosocial needs that must be addressed by health-care professionals, particularly in the primary-care setting following genetic disclosure of a potentially reassuring result regarding their lack of the very high cancer risks associated with BRCA1/2 mutations. Accepted for publication 28 November 2007. Adapted from the source document. JF - Health Expectations AU - Bakos, Alexis D AU - Hutson, Sadie P AU - Loud, Jennifer T AU - Peters, June A AU - Giusti, Ruthann M AU - Greene, Mark H AD - National Cancer Institute, National Institutes of Health, Rockville, MD, USA Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 220 EP - 231 PB - Blackwell Publishing, Oxford UK VL - 11 IS - 3 SN - 1369-6513, 1369-6513 KW - Ovarian cancer KW - Women KW - Breast cancer KW - Disclosure KW - Risk perception KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57296781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Expectations&rft.atitle=BRCA+mutation-negative+women+from+hereditary+breast+and+ovarian+cancer+families%3A+a+qualitative+study+of+the+BRCA-negative+experience&rft.au=Bakos%2C+Alexis+D%3BHutson%2C+Sadie+P%3BLoud%2C+Jennifer+T%3BPeters%2C+June+A%3BGiusti%2C+Ruthann+M%3BGreene%2C+Mark+H&rft.aulast=Bakos&rft.aufirst=Alexis&rft.date=2008-09-01&rft.volume=11&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Health+Expectations&rft.issn=13696513&rft_id=info:doi/10.1111%2Fj.1369-7625.2008.00494.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HEHPFM N1 - SubjectsTermNotLitGenreText - Breast cancer; Ovarian cancer; Women; Cancer; Risk perception; Disclosure DO - http://dx.doi.org/10.1111/j.1369-7625.2008.00494.x ER - TY - JOUR T1 - Parenting and the Young Driver Problem AN - 57274532; 200902561 AB - Crash rates increase sharply at the age at which teenagers begin to drive and remain elevated relative to adult levels until drivers are well into their twenties. Parents have important roles to play in managing the risk for teenage drivers before and after licensure. Parents can be involved in their teenagers' driving, allowing them to test for permit and licensure, supervising practice driving, providing access to a vehicle, and setting and enforcing limits on driving privileges after licensure. However, the management practices of many parents may not be sufficient to provide safety effects. The literature indicates that the two most important decisions parents can make to reduce teenagers' driving risk are to delay licensure and impose limits on high-risk driving conditions (such as driving at night and with teenage passengers) during the first year of licensure. Two intervention programs have been shown to increase parental limit setting as a means of reducing risky driving behaviors and improving driving performance among novice teenage drivers. This article describes the contexts of and opportunities for parental involvement in teenage driving and the effectiveness of interventions to increase and improve parental management of young drivers. [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Simons-Morton, Bruce G AU - Ouimet, Marie Claude AU - Catalano, Richard F AD - Prevention Research Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland Y1 - 2008/09// PY - 2008 DA - September 2008 SP - S294 EP - S303 PB - Elsevier Science, New York NY VL - 35 IS - 3S1 SN - 0749-3797, 0749-3797 KW - Preventive strategies KW - Motor vehicles KW - Parental participation KW - Road accidents KW - Adolescents KW - Dangerous driving KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57274532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Parenting+and+the+Young+Driver+Problem&rft.au=Simons-Morton%2C+Bruce+G%3BOuimet%2C+Marie+Claude%3BCatalano%2C+Richard+F&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2008-09-01&rft.volume=35&rft.issue=3S1&rft.spage=S294&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.06.018 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Adolescents; Motor vehicles; Road accidents; Dangerous driving; Parental participation; Preventive strategies DO - http://dx.doi.org/10.1016/j.amepre.2008.06.018 ER - TY - JOUR T1 - Adolescent development: Behavioral and Social Science Contributions to Preventing Teen Motor Crashes Systems Integrative and Interdisciplinary Approaches AN - 57273535; 200901180 AB - Describes the role of the Office of Behavioral & Social Sciences Research (OBSSR) at the National Insits of Health in coordinating approaches to the problem of preventing motor vehicle crashes among US teenagers. The need for multilevel interventions & interdisciplinary collaboration in addressing this public health problem is stressed. References. K. Hyatt Stewart [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Blachman, Dara R AU - Abrams, David AD - SRCD/AAAS Policy Fellow placed at the Office of Behavioral and Social Sciences Research, Office of the Director, Bethesda, Maryland blachmand@od.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - S285 EP - S288 PB - Elsevier Science, New York NY VL - 35 IS - 3S1 SN - 0749-3797, 0749-3797 KW - Motor vehicles KW - Interdisciplinary approach KW - Preventive strategies KW - Road accidents KW - Adolescents KW - Dangerous driving KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57273535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Adolescent+development%3A+Behavioral+and+Social+Science+Contributions+to+Preventing+Teen+Motor+Crashes+Systems+Integrative+and+Interdisciplinary+Approaches&rft.au=Blachman%2C+Dara+R%3BAbrams%2C+David&rft.aulast=Blachman&rft.aufirst=Dara&rft.date=2008-09-01&rft.volume=35&rft.issue=3S1&rft.spage=S285&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.06.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Adolescents; Road accidents; Dangerous driving; Preventive strategies; Interdisciplinary approach; Motor vehicles DO - http://dx.doi.org/10.1016/j.amepre.2008.06.003 ER - TY - JOUR T1 - Blending addiction research and practice: Strategies for technology transfer AN - 57273229; 200821230 AB - Consistent with traditional conceptions of technology transfer, efforts to translate substance abuse and addiction research into treatment practice have typically relied on the passive dissemination of research findings. The large gap between addiction research and practice, however, indicates that there are many barriers to successful technology transfer and that dissemination alone is not sufficient to produce lasting changes in addiction treatment. To accelerate the translation of research into practice, the National Institute on Drug Abuse launched the Blending Initiative in 2001. In part a collaboration with the Substance Abuse and Mental Health Services Administration/Center for Substance Abuse Treatment's Addiction Technology Transfer Center program, this initiative aims to improve the development, effectiveness, and usability of evidence-based practices and reduce the obstacles to their timely adoption and implementation. [Copyright 2008 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Condon, Timothy P AU - Miner, Lucinda L AU - Balmer, Curtis W AU - Pintello, Denise AD - National Institute on Drug Abuse, Bethesda, MD 20892-9581, USA Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 156 EP - 160 PB - Elsevier, New York NY VL - 35 IS - 2 SN - 0740-5472, 0740-5472 KW - Addiction treatment KW - Technology transfer KW - Evidence-based practices KW - Clinical Trials Network (CTN) KW - Addiction Technology Transfer Center (ATTC) KW - Evidence based KW - Mental health services KW - Addiction KW - Treatment KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57273229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Blending+addiction+research+and+practice%3A+Strategies+for+technology+transfer&rft.au=Condon%2C+Timothy+P%3BMiner%2C+Lucinda+L%3BBalmer%2C+Curtis+W%3BPintello%2C+Denise&rft.aulast=Condon&rft.aufirst=Timothy&rft.date=2008-09-01&rft.volume=35&rft.issue=2&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2007.09.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Technology transfer; Substance abuse; Addiction; Mental health services; Evidence based; Treatment DO - http://dx.doi.org/10.1016/j.jsat.2007.09.004 ER - TY - JOUR T1 - Does areca nut use lead to dependence? AN - 57257570; 200821006 AB - Background The areca nut is consumed by approximately 10% of the world's population, and its consumption is associated with long-term health risks, with or without tobacco additives. However, it is not known whether its use is associated with a dependence syndrome, as is seen with other psychoactive substances. Objective To examine whether areca nut usage (with or without tobacco additives) could lead to the development of a dependence syndrome. Methods Three groups: [a] persons using areca nut preparations without tobacco additives [n = 98]; [b] persons using areca nut preparations with tobacco additives [n = 44]; and [c] 'Non-users' were systematically assessed using a checklist for the use of areca or areca + tobacco products, patterns of use, presence of a dependence syndrome in users, features of stimulant withdrawal and desired/beneficial effects. Results 38.8% and 40.8% of the 'areca' group satisfied definitions of current substance-dependence according to DSM-IV and ICD-10 criteria respectively. 79.5% of the areca + tobacco group satisfied criteria for current dependent use according to both DSM-IV and ICD-10 criteria. Both the groups reported a well-delineated withdrawal syndrome and similar attributions for desirable effects of use. Conclusion Areca nut use by itself and more so with tobacco additives, is associated with the development of a dependence syndrome in a substantial numbers of users. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Benegal, Vivek AU - Rajkumar, Ravi P AU - Muralidharan, Kesavan AD - Deaddiction Centre, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India vbenegal@gmail.com Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 114 EP - 121 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 97 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Areca KW - Betel KW - Dependence KW - Withdrawal KW - India KW - Health risks KW - Tobacco products KW - Betel nuts KW - Withdrawal symptoms KW - Substance dependency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57257570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Does+areca+nut+use+lead+to+dependence%3F&rft.au=Benegal%2C+Vivek%3BRajkumar%2C+Ravi+P%3BMuralidharan%2C+Kesavan&rft.aulast=Benegal&rft.aufirst=Vivek&rft.date=2008-09-01&rft.volume=97&rft.issue=1-2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.03.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Health risks; Betel nuts; Tobacco products; Substance dependency; Withdrawal symptoms DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.03.016 ER - TY - JOUR T1 - Self-report of illicit benzodiazepine use on the Addiction Severity Index predicts treatment outcome AN - 57254753; 200821555 AB - The relationship between pre-treatment illicit benzodiazepine use (days of use in the last 30) assessed on the Addiction Severity Index (ASI) and treatment outcome was investigated by retrospective analysis of data from two controlled clinical trials in 361 methadone maintained cocaine/opiate users randomly assigned to 12-week voucher- or prize-based contingency management (CM) or control interventions. Based on screening ASI, participants were identified as non-users (BZD-N; 0 days of use) or users (BZD-U; >0 days of use). Outcome measures were: urine drug screens (thrice weekly); quality of life and self-reported HIV-risk behaviors (every 2 weeks); and current DSM-IV diagnosis of cocaine and heroin dependence (study exit). In the CM group, BZD-U had significantly worse outcomes on in-treatment cocaine use, quality-of-life scores, needle-sharing behaviors, and current heroin dependence diagnoses at study exit compared to BZD-N. In the control group, BZD-U had significantly higher in-treatment cocaine use but did not differ from BZD-N on psychosocial measures. Thus, in a sample of non-dependent BZD users, self-reported illicit BZD use on the ASI, even at low levels, predicted worse outcome on cocaine use and blunted response to CM. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ghitza, Udi E AU - Epstein, David H AU - Preston, Kenzie L AD - Clinical Pharmacology and Therapeutics Research Branch, Treatment Section, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, MD 21224, USA ghitzau@intra.nida.nih.gov Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 150 EP - 157 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 97 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Contingency management KW - Cocaine abuse KW - Heroin abuse KW - Opiate KW - Benzodiazepine KW - Benzodiazepines KW - Residential treatment KW - Risk behaviour KW - Cocaine KW - HIV KW - Drug addiction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57254753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Self-report+of+illicit+benzodiazepine+use+on+the+Addiction+Severity+Index+predicts+treatment+outcome&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2008-09-01&rft.volume=97&rft.issue=1-2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.04.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Drug addiction; Risk behaviour; HIV; Residential treatment; Cocaine; Benzodiazepines DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.04.003 ER - TY - JOUR T1 - Childhood Obesity Prevention and Treatment Recommendations for Future Research AN - 57253521; 200822474 AB - This report summarizes the National Heart, Lung, and Blood Institute Working Group's recommendations on future research directions in childhood obesity prevention and treatment. The Working Group consisted of leaders and representatives from public and private academic and medical institutions with expertise in a variety of health specialties. They reviewed the literature and discussed the findings as well as their own experiences in the prevention and treatment of childhood obesity. The Working Group made recommendations that were based on scientific importance, the potential likelihood of public health impact, and the feasibility and timeliness for childhood obesity prevention and treatment research. These recommendations are intended to assist investigators in the development of research agendas to advance the knowledge of effective childhood obesity prevention and treatment. [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Pratt, Charlotte A AU - Stevens, June AU - Daniels, Stephen AD - Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, NIH, 6701 Rockledge Drive, MSC 7936, Room 10118, Bethesda MD 20892 prattc@nhlbi.rih.go Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 249 EP - 252 PB - Elsevier Science, New York NY VL - 35 IS - 3 SN - 0749-3797, 0749-3797 KW - Obesity KW - Childhood KW - Obese children KW - Treatment KW - Preventive programmes KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Childhood+Obesity+Prevention+and+Treatment+Recommendations+for+Future+Research&rft.au=Pratt%2C+Charlotte+A%3BStevens%2C+June%3BDaniels%2C+Stephen&rft.aulast=Pratt&rft.aufirst=Charlotte&rft.date=2008-09-01&rft.volume=35&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.+1016%2Fj.amepre.2008.05.025 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Obese children; Obesity; Childhood; Preventive programmes; Treatment; Public health DO - http://dx.doi.org/10. 1016/j.amepre.2008.05.025 ER - TY - JOUR T1 - Breast cancer relative hazard estimates from case-control and cohort designs with missing data on mammographic density AN - 37024108; 3804668 JF - Journal of the American Statistical Association AU - Chen, Jinbo AU - Ayyagari, Rajeev AU - Chatterjee, Nilanjan AU - Pee, David Y AU - Schairer, Catherine AU - Byrne, Celia AU - Benichou, Jacques AU - Gail, Mitchell H AD - University of Pennsylvania ; National Cancer Institute ; Georgetown University ; Université de Rouen Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 976 EP - 988 VL - 103 IS - 483 SN - 0162-1459, 0162-1459 KW - Economics KW - Medical sociology KW - Case studies KW - Cohort analysis KW - Regression analysis KW - Statistical analysis KW - Estimation KW - Statistical methods KW - Cancer KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37024108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Breast+cancer+relative+hazard+estimates+from+case-control+and+cohort+designs+with+missing+data+on+mammographic+density&rft.au=Chen%2C+Jinbo%3BAyyagari%2C+Rajeev%3BChatterjee%2C+Nilanjan%3BPee%2C+David+Y%3BSchairer%2C+Catherine%3BByrne%2C+Celia%3BBenichou%2C+Jacques%3BGail%2C+Mitchell+H&rft.aulast=Chen&rft.aufirst=Jinbo&rft.date=2008-09-01&rft.volume=103&rft.issue=483&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214507000000120 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12224 971; 7887 12008; 1939 3617 6220; 7994; 10739 12228 10919; 4403 7854; 2457 2459 5676 3279 971 3286; 2056 10902 DO - http://dx.doi.org/10.1198/016214507000000120 ER - TY - JOUR T1 - Empirical likelihood-based estimation of the treatment effect in a pretest-posttest study AN - 37023664; 3804691 JF - Journal of the American Statistical Association AU - Huang, Chiung-yu AU - Qin, Jing AU - Follmann, Dean A AD - National Institute of Allergy and Infectious Diseases Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1270 EP - 1280 VL - 103 IS - 483 SN - 0162-1459, 0162-1459 KW - Economics KW - Information KW - Survey analysis KW - Medical research KW - Statistical analysis KW - Sample surveys KW - Medical treatment KW - Empirical research KW - Statistical methods KW - Bias UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37023664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Empirical+likelihood-based+estimation+of+the+treatment+effect+in+a+pretest-posttest+study&rft.au=Huang%2C+Chiung-yu%3BQin%2C+Jing%3BFollmann%2C+Dean+A&rft.aulast=Huang&rft.aufirst=Chiung-yu&rft.date=2008-09-01&rft.volume=103&rft.issue=483&rft.spage=1270&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214508000000625 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12224 971; 4200 10902; 7890 5792 10484; 7886 10902; 12426 3279 971 3286; 11253 12429; 6515; 1565 1362 2688 2449 10404 DO - http://dx.doi.org/10.1198/016214508000000625 ER - TY - JOUR T1 - Analysis of smoking cessation patterns using a stochastic mixed-effects model with a latent cured state AN - 37022952; 3804670 JF - Journal of the American Statistical Association AU - Luo, Sheng AU - Crainiceanu, Ciprian M AU - Louis, Thomas A AU - Chatterjee, Nilanjan AD - Johns Hopkins University ; National Cancer Institute Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1002 EP - 1013 VL - 103 IS - 483 SN - 0162-1459, 0162-1459 KW - Economics KW - Stochastic processes KW - Smoking KW - Prevention KW - Medical care KW - Model testing KW - Statistical analysis KW - Statistical methods KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37022952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Analysis+of+smoking+cessation+patterns+using+a+stochastic+mixed-effects+model+with+a+latent+cured+state&rft.au=Luo%2C+Sheng%3BCrainiceanu%2C+Ciprian+M%3BLouis%2C+Thomas+A%3BChatterjee%2C+Nilanjan&rft.aulast=Luo&rft.aufirst=Sheng&rft.date=2008-09-01&rft.volume=103&rft.issue=483&rft.spage=1002&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214507000001030 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12224 971; 11755 5707 6071 1542 11325; 12265 3865 4025 10214 12224 971 12228 10919; 8160 8163; 7875 5775 13521; 10449 5772; 10072 DO - http://dx.doi.org/10.1198/016214507000001030 ER - TY - JOUR T1 - Improving semiparametric estimation by using surrogate data AN - 36927678; 3753349 AB - The paper considers estimating a parameter ß that defines an estimating function U(y,x, ß) for an outcome variable y and its covariate x when the outcome is missing in some of the observations. We assume that, in addition to the outcome and the covariate, a surrogate outcome is available in every observation. The efficiency of existing estimators for ß depends critically on correctly specifying the conditional expectation of U given the surrogate and the covariate. When the conditional expectation is not correctly specified, which is the most likely scenario in practice, the efficiency of estimation can be severely compromised even if the propensity function (of missingness) is correctly specified. We propose an estimator that is robust against the choice of the conditional expectation via an empirical likelihood. We demonstrate that the estimator proposed achieves a gain in efficiency whether the conditional score is correctly specified or not. When the conditional score is correctly specified, the estimator reaches the semiparametric variance bound within the class of estimating functions that are generated by U. The practical performance of the estimator is evaluated by using simulation and a data set that is based on the 1996 US presidential election. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Chen, S X AU - Leung, D.H.Y. AU - Qin, J AD - Iowa State University ; Singapore Management University ; US National Institutes of Health Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 803 EP - 824 VL - 70 IS - 4 SN - 1369-7412, 1369-7412 KW - Political Science KW - Presidential elections KW - Data collection KW - Model testing KW - Statistical models KW - Estimation KW - U.S.A. KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36927678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Improving+semiparametric+estimation+by+using+surrogate+data&rft.au=Chen%2C+S+X%3BLeung%2C+D.H.Y.%3BQin%2C+J&rft.aulast=Chen&rft.aufirst=S&rft.date=2008-09-01&rft.volume=70&rft.issue=4&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 4403 7854; 12230 8163; 3286; 8160 8163; 10058 4128; 433 293 14 ER - TY - JOUR T1 - A New Luminescence Assay for Autoantibodies to Mammalian CellaPrepared Insulinoma-Associated Protein 2 AN - 21443811; 11862405 AB - OBJECTIVEInsulinoma-associated protein 2 (IA-2) is a major autoantigen in type 1 diabetes, and IA-2 autoantibodies are routinely detected by a liquid-phase radioimmunoprecipitation assay. The present experiments were initiated to develop a new assay that does not require the use of radioisotopes or autoantigens prepared in bacteria or by in vitro transcription/translation. RESEARCH DESIGN AND METHODSIA-2 luciferase fusion protein was expressed in mammalian cells and assayed for autoantibodies by liquid-phase luciferase immunoprecipitation. RESULTSOur study showed that there was no significant difference between the luciferase immunoprecipitation and the radioimmunoprecipitation assays in sensitivity and specificity, and comparison of the two assays revealed a high correlation coefficient (R super(2) = 0.805). CONCLUSIONSThe luciferase system offers a robust, inexpensive, nonradioactive method for the detection of autoantibodies to mammalian cellaprepared IA-2 and could be of practical value at the clinical level. JF - Diabetes Care AU - Burbelo, Peter D AU - Hirai, Hiroki AU - Leahy, Hannah AU - Lernmark, Ake AU - Ivarsson, Sten A AU - Iadarola, Michael J AU - Louis Notkins, Abner AD - Sensory Biology Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1824 EP - 1826 PB - American Diabetes Association, 1701 N. Beauregard St. Alexandria VA 22311 USA VL - 31 IS - 9 SN - 0149-5992, 0149-5992 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Diabetes mellitus KW - Translation KW - Autoantibodies KW - Mammalian cells KW - Immunoprecipitation KW - Radioisotopes KW - Transcription KW - Fusion protein KW - Luminescence KW - Autoantigens KW - F 06930:Autoimmunity KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21443811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+Care&rft.atitle=A+New+Luminescence+Assay+for+Autoantibodies+to+Mammalian+CellaPrepared+Insulinoma-Associated+Protein+2&rft.au=Burbelo%2C+Peter+D%3BHirai%2C+Hiroki%3BLeahy%2C+Hannah%3BLernmark%2C+Ake%3BIvarsson%2C+Sten+A%3BIadarola%2C+Michael+J%3BLouis+Notkins%2C+Abner&rft.aulast=Burbelo&rft.aufirst=Peter&rft.date=2008-09-01&rft.volume=31&rft.issue=9&rft.spage=1824&rft.isbn=&rft.btitle=&rft.title=Diabetes+Care&rft.issn=01495992&rft_id=info:doi/10.2337%2Fdc08-0286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Translation; Mammalian cells; Autoantibodies; Radioisotopes; Immunoprecipitation; Transcription; Fusion protein; Luminescence; Autoantigens DO - http://dx.doi.org/10.2337/dc08-0286 ER - TY - JOUR T1 - IICBU 2008: a proposed benchmark suite for biological image analysis AN - 21320115; 11890923 AB - New technology for automated biological image acquisition has introduced the need for effective biological image analysis methods. These algorithms are constantly being developed by pattern recognition and machine vision experts, who tailor general computer vision techniques to the specific needs of biological imaging. However, computer scientists do not always have access to biological image datasets that can be used for computer vision research, and biologist collaborators who can assist in defining the biological questions are not always available. Here, we propose a publicly available benchmark suite of biological image datasets that can be used by machine vision experts for developing and evaluating biological image analysis methods. The suite represents a set of practical real-life imaging problems in biology, and offers examples of organelles, cells and tissues, imaged at different magnifications and different contrast techniques. All datasets are available for free download at http://ome.grc.nia.nih.gov/iicbu2008. JF - Medical & Biological Engineering & Computing AU - Shamir, Lior AU - Orlov, Nikita AU - Mark Eckley, David AU - Macura, Tomasz J AU - Goldberg, Ilya G AD - Laboratory of Genetics, Image Informatics and Computational Biology Unit, NIA/NIH, 333 Cassell Dr, Baltimore, MD, 21224, USA, shamirl@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 943 EP - 947 PB - Institution of Electrical Engineers, Savoy Pl. London WC2R 0BL UK VL - 46 IS - 9 SN - 0140-0118, 0140-0118 KW - Biotechnology and Bioengineering Abstracts KW - Pattern recognition KW - Vision KW - Computers KW - Algorithms KW - Image processing KW - Organelles KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21320115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+%26+Biological+Engineering+%26+Computing&rft.atitle=IICBU+2008%3A+a+proposed+benchmark+suite+for+biological+image+analysis&rft.au=Shamir%2C+Lior%3BOrlov%2C+Nikita%3BMark+Eckley%2C+David%3BMacura%2C+Tomasz+J%3BGoldberg%2C+Ilya+G&rft.aulast=Shamir&rft.aufirst=Lior&rft.date=2008-09-01&rft.volume=46&rft.issue=9&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=Medical+%26+Biological+Engineering+%26+Computing&rft.issn=01400118&rft_id=info:doi/10.1007%2Fs11517-008-0380-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Vision; Image processing; Computers; imaging; Algorithms; Organelles; Pattern recognition DO - http://dx.doi.org/10.1007/s11517-008-0380-5 ER - TY - JOUR T1 - Impact of celecoxib on capecitabine tolerability and activity in pretreated metastatic breast cancer: results of a phase II study with biomarker evaluation AN - 21245490; 8410709 AB - Background: Preclinical evidence suggests that the cyclo-oxygenase-2 (COX-2) enzyme plays an important role in breast cancer progression. The aim of the present phase II study was to determine the activity and safety of the combination of the COX-2 inhibitor celecoxib with capecitabine in metastatic breast cancer (MBC) patients pretreated with anthracyclines and/or taxanes. Methods: Eligible patients received capecitabine 1,000 mg/m[sup2 ] twice daily on days 1-14 every 21 days and celecoxib 200 mg twice daily, continuously, until disease progression or unacceptable toxicity. Results: About 42 pretreated MBC patients were enrolled into the study. Median number of previous chemotherapy lines for metastatic disease was 2 (0-3). Seven patients (19%) responded to treatment while disease stabilization occurred in 17 patients (40.5%). Overall, 20 patients (47.5%) achieved clinical benefit [objective responses (CR) plus stable disease (SD) .6 months]. Median time to progression (TTP) and median overall survival (OS) were 5.2 and 17.8 months, respectively. Treatment was very well tolerated: grade 3 toxicities were observed in only five patients, respectively, and no grade 4 adverse events were reported. Celecoxib was never discontinued for toxicity. Analysis of COX-2 expression in the 22 patients with available tissue revealed a significantly longer TTP and OS for patients whose tumors over-expressed COX-2. Conclusions: The combination of capecitabine and celecoxib is active and safe in far advanced MBC patients. Interestingly, this association resulted in a lower-than-expected toxicity, as compared to single-agent capecitabine. The clinical relevance of COX-2 as determinant of sensitivity to treatment with celecoxib should be further evaluated in larger series of patients. JF - Cancer Chemotherapy and Pharmacology AU - Fabi, Alessandra AU - Metro, Giulio AU - Papaldo, Paola AU - Mottolese, Marcella AU - Melucci, Elisa AU - Carlini, Paolo AU - Sperduti, Isabella AU - Russillo, Michelangelo AU - Gelibter, Alain AU - Ferretti, Gianluigi AU - Tomao, Silverio AU - Milella, Michele AU - Cognetti, Francesco AD - Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144, Rome, Italy, milella@ifo.it Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 717 EP - 725 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 62 IS - 4 SN - 0344-5704, 0344-5704 KW - Toxicology Abstracts KW - Cyclooxygenase-2 KW - Celecoxib KW - Chemotherapy KW - Survival KW - Enzymes KW - taxanes KW - Toxicity KW - Tumors KW - biomarkers KW - Metastases KW - Breast cancer KW - Anthracycline KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21245490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Chemotherapy+and+Pharmacology&rft.atitle=Impact+of+celecoxib+on+capecitabine+tolerability+and+activity+in+pretreated+metastatic+breast+cancer%3A+results+of+a+phase+II+study+with+biomarker+evaluation&rft.au=Fabi%2C+Alessandra%3BMetro%2C+Giulio%3BPapaldo%2C+Paola%3BMottolese%2C+Marcella%3BMelucci%2C+Elisa%3BCarlini%2C+Paolo%3BSperduti%2C+Isabella%3BRussillo%2C+Michelangelo%3BGelibter%2C+Alain%3BFerretti%2C+Gianluigi%3BTomao%2C+Silverio%3BMilella%2C+Michele%3BCognetti%2C+Francesco&rft.aulast=Fabi&rft.aufirst=Alessandra&rft.date=2008-09-01&rft.volume=62&rft.issue=4&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Cancer+Chemotherapy+and+Pharmacology&rft.issn=03445704&rft_id=info:doi/10.1007%2Fs00280-007-0650-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Metastases; Cyclooxygenase-2; Celecoxib; Chemotherapy; taxanes; Enzymes; Survival; Breast cancer; Tumors; Toxicity; Anthracycline; biomarkers DO - http://dx.doi.org/10.1007/s00280-007-0650-1 ER - TY - JOUR T1 - Novel Dual-Reporter Preclinical Screen for Antiastrocytoma Agents Identifies Cytostatic and Cytotoxic Compounds AN - 21201191; 11621776 AB - Astrocytoma/glioblastoma is the most common malignant form of brain cancer and is often unresponsive to current pharmacological therapies and surgical interventions. Despite several potential therapeutic agents against astrocytoma and glioblastoma, there are currently no effective therapies for astrocytoma, creating a great need for the identification of effective antitumor agents. The authors have developed a novel dual-reporter system in Trp53/Nf1-null astrocytoma cells to simultaneously and rapidly assay cell viability and cell cycle progression as evidenced by activity of the human E2F1 promoter in vitro. The dual-reporter high-throughput assay was used to screen experimental therapeutics for activity in Trp53/Nf1-null astrocytoma. Several compounds were identified demonstrating selectivity for astrocytoma over primary astrocytes. The dual-reporter system described here may be a valuable tool for identifying potential antitumor treatments that specifically target astrocytoma. (Journal of Biomolecular Screening 2008:795-803) JF - Journal of Biomolecular Screening AU - Hawes, Jessica J AU - Nerva, John D AU - Reilly, Karlyne M AD - Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 795 EP - 803 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 13 IS - 8 SN - 1087-0571, 1087-0571 KW - Biotechnology and Bioengineering Abstracts KW - Glioblastoma KW - Promoters KW - Cytotoxicity KW - Astrocytoma cells KW - Astrocytoma KW - Astrocytes KW - Cell cycle KW - Brain KW - Antitumor agents KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21201191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Novel+Dual-Reporter+Preclinical+Screen+for+Antiastrocytoma+Agents+Identifies+Cytostatic+and+Cytotoxic+Compounds&rft.au=Hawes%2C+Jessica+J%3BNerva%2C+John+D%3BReilly%2C+Karlyne+M&rft.aulast=Hawes&rft.aufirst=Jessica&rft.date=2008-09-01&rft.volume=13&rft.issue=8&rft.spage=795&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057108321085 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Promoters; Glioblastoma; Cytotoxicity; Astrocytoma cells; Astrocytes; Astrocytoma; Cell cycle; Brain; Antitumor agents; Cancer DO - http://dx.doi.org/10.1177/1087057108321085 ER - TY - JOUR T1 - Transcriptional activation by MarA, SoxS and Rob of two tolC promoters using one binding site: a complex promoter configuration for tolC in Escherichia coli AN - 21052246; 8485922 AB - The Escherichia coli tolC encodes a major outer membrane protein with multiple functions in export (e.g. diverse xenobiotics, haemolysin) and as an attachment site for phage and colicins. tolC is regulated in part by MarA, SoxS and Rob, three paralogous transcriptional activators which bind a sequence called the marbox and which activate multiple antibiotic and superoxide resistance functions. Two previously identified tolC promoters, p1 and p2, are not regulated by MarA, SoxS or Rob but p2 is activated by EvgAS and PhoPQ which also regulate other functions. Using transcriptional fusions and primer extension assays, we show here that tolC has two additional strong overlapping promoters, p3 and p4, which are downstream of p1, p2 and the marbox and are activated by MarA, SoxS and Rob. p3 and p4 are configured so that a single marbox suffices to activate transcription from both promoters. At the p3 promoter, the marbox is separated by 20 bp from the -10 hexamer for RNA polymerase but at the p4 promoter, the same marbox is separated by 30 bp from the -10 hexamer. The multiple tolC promoters may allow the cell to respond to diverse environments by co-ordinating tolC transcription with other appropriate functions. JF - Molecular Microbiology AU - Zhang, Aixia AU - Rosner, Judah L AU - Martin, Robert G AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, and, jlrosner@helix.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1450 EP - 1455 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 69 IS - 6 SN - 0950-382X, 0950-382X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Phages KW - hexamers KW - SoxS protein KW - Transcription KW - Antibiotics KW - Xenobiotics KW - Promoters KW - DNA-directed RNA polymerase KW - Transcription factors KW - Superoxide KW - Escherichia coli KW - Colicins KW - Primers KW - Major outer membrane protein KW - Transcription activation KW - N 14830:RNA KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21052246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Transcriptional+activation+by+MarA%2C+SoxS+and+Rob+of+two+tolC+promoters+using+one+binding+site%3A+a+complex+promoter+configuration+for+tolC+in+Escherichia+coli&rft.au=Zhang%2C+Aixia%3BRosner%2C+Judah+L%3BMartin%2C+Robert+G&rft.aulast=Zhang&rft.aufirst=Aixia&rft.date=2008-09-01&rft.volume=69&rft.issue=6&rft.spage=1450&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06371.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phages; hexamers; SoxS protein; Transcription; Antibiotics; Xenobiotics; Promoters; DNA-directed RNA polymerase; Superoxide; Transcription factors; Colicins; Primers; Major outer membrane protein; Transcription activation; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06371.x ER - TY - JOUR T1 - Plasmodium falciparum: Food vacuole localization of nitric oxide-derived species in intraerythrocytic stages of the malaria parasite AN - 20969100; 8515280 AB - Nitric oxide (NO) has diverse biological functions. Numerous studies have documented NO's biosynthetic pathway in a wide variety of organisms. Little is known, however, about NO production in intraerythrocytic Plasmodium falciparum. Using diaminorhodamine-4-methyl acetoxymethylester (DAR-4M AM), a fluorescent indicator, we obtained direct evidence of NO and NO-derived reactive nitrogen species (RNS) production in intraerythrocytic P. falciparum parasites, as well as in isolated food vacuoles from trophozoite stage parasites. We preliminarily identified two gene sequences that might be implicated in NO synthesis in intraerythrocytic P. falciparum. We showed localization of the protein product of one of these two genes, a molecule that is structurally similar to a plant nitrate reductase, in trophozoite food vacuole membranes. We confirmed previous reports on the antiproliferative effect of NOS (nitric oxide synthase) inhibitors in P. falciparum cultures; however, we did not obtain evidence that NOS inhibitors had the ability to inhibit RNS production or that there is an active NOS in mature forms of the parasite. We concluded that a nitrate reductase activity produce NO and NO-derived RNS in or around the food vacuole in P. falciparum parasites. The food vacuole is a critical parasitic compartment involved in hemoglobin degradation, heme detoxification and a target for antimalarial drug action. Characterization of this relatively unexplored synthetic activity could provide important clues into poorly understood metabolic processes of the malaria parasite. JF - Experimental Parasitology AU - Ostera, G AU - Tokumasu, F AU - Oliveira, F AU - Sa, J AU - Furuya, T AU - Teixeira, C AU - Dvorak, J AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Twinbrook III, Room 2W-09, Rockville, MD 20852, USA, gostera@niaid.nih.gov Y1 - 2008/09// PY - 2008 DA - September 2008 SP - 29 EP - 38 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 120 IS - 1 SN - 0014-4894, 0014-4894 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Detoxification KW - Parasites KW - Human diseases KW - Heme KW - Nitrate reductase KW - reactive nitrogen species KW - Malaria KW - Plasmodium falciparum KW - Food plants KW - Public health KW - Hemoglobin KW - Nitric-oxide synthase KW - Fluorescent indicators KW - Inhibitors KW - Nitric oxide KW - Food vacuoles KW - Drugs KW - Haemoglobins KW - Trophozoites KW - G 07800:Plants and Algae KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20969100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Parasitology&rft.atitle=Plasmodium+falciparum%3A+Food+vacuole+localization+of+nitric+oxide-derived+species+in+intraerythrocytic+stages+of+the+malaria+parasite&rft.au=Ostera%2C+G%3BTokumasu%2C+F%3BOliveira%2C+F%3BSa%2C+J%3BFuruya%2C+T%3BTeixeira%2C+C%3BDvorak%2C+J&rft.aulast=Ostera&rft.aufirst=G&rft.date=2008-09-01&rft.volume=120&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Experimental+Parasitology&rft.issn=00144894&rft_id=info:doi/10.1016%2Fj.exppara.2008.04.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Detoxification; Parasites; Human diseases; Inhibitors; Malaria; Drugs; Haemoglobins; Public health; Heme; Nitrate reductase; reactive nitrogen species; Food plants; Nitric-oxide synthase; Hemoglobin; Fluorescent indicators; Nitric oxide; Food vacuoles; Trophozoites; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.exppara.2008.04.014 ER - TY - JOUR T1 - Elemental and organic carbon exposure in highway tollbooths: A study of Taiwanese toll station workers AN - 20923326; 8417381 AB - The carbon composition of fine particles (PM sub(2) sub(.) sub(5)) from traffic exhausts may play a role in adverse health effects. The objective of this study was to assess the concentrations of elemental and organic carbon in PM sub(2) sub(.) sub(5) in traffic exhausts from different types of vehicles in the booths of Taiwanese toll station workers and estimate the relations between traffic density and carbon concentrations. Tollbooth indoor monitoring samples were collected for 10 days to assess the 8 h integrated PM sub(2) sub(.) sub(5) concentration. Particle samples were analyzed for the content of total carbon, and elemental, and organic carbon. The mean carbon concentrations in the bus and truck lanes were [total: 167.7 ?g/m super(3) (SD 79.8 ?g /m super(3)); elemental: 131.7 (66.2); organic: 36.0 (25.8)], substantially higher compared with the car lanes with cash payment [39.2 (29.5); 20.2 (19.5); 19.2 (14.6)] and the car lanes with ticket payment [34.1 (26.1); 15.8 (17.6); 18.5 (12.2)]. The increase in elemental carbon concentration per vehicle in the bus and truck lane was 14 and 9 times greater than that of car lanes of ticket payment and car lanes of cash payment. The mass fraction of carbonaceous species in PM sub(2) sub(.) sub(5) accounted for 54% in bus and truck lanes, whereas the corresponding figure was 30-31% for car lanes. Elemental carbon is an important component of diesel exhaust. Workers in toll stations are exposed to high levels of both elemental and organic carbon. JF - Science of the Total Environment AU - Shih, T S AU - Lai, CH AU - Hung, H F AU - Ku, SY AU - Tsai, P J AU - Yang, T AU - Liou, SH AU - Loh, CH AU - Jaakkola, JJK AD - Tri-Service General Hospital, National Defense Medical Center, 325 Cheng-Kung Road, Sec. 2, Nei-Hu, Taipei, Taiwan 114, ROC, twdoc@ndmctscgh.edu.tw Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 163 EP - 170 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 402 IS - 2-3 SN - 0048-9697, 0048-9697 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Particle size KW - traffic KW - Organic carbon KW - Trucks KW - Particulates KW - Diesel engines KW - Highways KW - Occupational exposure KW - Exhaust emissions KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20923326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+of+the+Total+Environment&rft.atitle=Elemental+and+organic+carbon+exposure+in+highway+tollbooths%3A+A+study+of+Taiwanese+toll+station+workers&rft.au=Shih%2C+T+S%3BLai%2C+CH%3BHung%2C+H+F%3BKu%2C+SY%3BTsai%2C+P+J%3BYang%2C+T%3BLiou%2C+SH%3BLoh%2C+CH%3BJaakkola%2C+JJK&rft.aulast=Shih&rft.aufirst=T&rft.date=2008-09-01&rft.volume=402&rft.issue=2-3&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Science+of+the+Total+Environment&rft.issn=00489697&rft_id=info:doi/10.1016%2Fj.scitotenv.2008.04.051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Particle size; traffic; Organic carbon; Trucks; Particulates; Highways; Diesel engines; Occupational exposure; Exhaust emissions DO - http://dx.doi.org/10.1016/j.scitotenv.2008.04.051 ER - TY - JOUR T1 - Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats AN - 20915056; 8453781 AB - Ventricular pressure-volume relationships have become well established as the most rigorous and comprehensive ways to assess intact heart function. Thanks to advances in miniature sensor technology, this approach has been successfully translated to small rodents, allowing for detailed characterization of cardiovascular function in genetically engineered mice, testing effects of pharmacotherapies and studying disease conditions. This method is unique for providing measures of left ventricular (LV) performance that are more specific to the heart and less affected by vascular loading conditions. Here we present descriptions and movies for procedures employing this method (anesthesia, intubation and surgical techniques, calibrations). We also provide examples of hemodynamics measurements obtained from normal mice/rats, and from animals with cardiac hypertrophy/heart failure, and describe values for various useful load-dependent and load-independent indexes of LV function obtained using different types of anesthesia. The completion of the protocol takes 1-4 h (depending on the experimental design/end points). JF - Nature Protocols AU - Pacher, Pal AU - Nagayama, Takahiro AU - Mukhopadhyay, Partha AU - Batkai, Sandor AU - Kass, David A AD - Section on Oxidative Stress Tissue Injury, Laboratories of Physiological Studies, National Institutes of Health/NIAAA, 5625 Fishers Lane, MSC-9413, Bethesda, Maryland 20892-9413, USA, pacher@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1422 EP - 1434 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 39 IS - 9 SN - 1754-2189, 1754-2189 KW - Biotechnology and Bioengineering Abstracts KW - Model organisms KW - Heart KW - Hypertrophy KW - Anesthesia KW - Conductance KW - Genetic engineering KW - Catheters KW - Hemodynamics KW - Intubation KW - Heart diseases KW - Vascular system KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20915056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Measurement+of+cardiac+function+using+pressure-volume+conductance+catheter+technique+in+mice+and+rats&rft.au=Pacher%2C+Pal%3BNagayama%2C+Takahiro%3BMukhopadhyay%2C+Partha%3BBatkai%2C+Sandor%3BKass%2C+David+A&rft.aulast=Pacher&rft.aufirst=Pal&rft.date=2008-09-01&rft.volume=39&rft.issue=9&rft.spage=1422&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.138 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Hypertrophy; Anesthesia; Conductance; Genetic engineering; Catheters; Hemodynamics; Intubation; Vascular system; Heart diseases DO - http://dx.doi.org/10.1038/nprot.2008.138 ER - TY - JOUR T1 - Family history of prostate cancer and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study AN - 20888507; 8367834 AB - Prostate cancer family history has been associated with increased risk of the malignancy. Most prior studies have been retrospective and subject to recall bias, however, and data evaluating interactions with other important risk factors are limited. We examined the relationship between a family history of prostate cancer and prostate cancer risk in relation to body size, micronutrients and other exposures in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort of Finnish male smokers. Family history of cancer information was self-reported once during the study in 1991, and anthropometry was measured by trained personnel. Among 19,652 men with complete data, 1,111 incident cases were identified during up to 12.3 years of follow-up. A first-degree family history of prostate cancer was associated with an overall relative risk (RR) of 1.91 (95% CI = 1.49-2.47) and a RR of 4.16 (95% CI = 2.67-6.49) for advanced disease (stage 3), adjusted for age and trial intervention. Our data also suggest that to some degree, height, body mass index, and serum -tocopherol and -carotene modify the family history and prostate cancer association, although the interactions were not statistically significant. Supplementation with vitamin E or -carotene did not modify the family history-prostate cancer association. This study provides additional evidence that family history is a significant risk factor for prostate cancer. JF - International Journal of Cancer AU - Ahn, Jiyoung AU - Moslehi, Roxana AU - Weinstein, Stephanie J AU - Snyder, Kirk AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, daa@nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1154 EP - 1159 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 5 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Genetics KW - Age KW - vitamins KW - body mass KW - intervention KW - prevention KW - micronutrients KW - body size KW - prostate cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20888507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Family+history+of+prostate+cancer+and+prostate+cancer+risk+in+the+Alpha-Tocopherol%2C+Beta-Carotene+Cancer+Prevention+%28ATBC%29+Study&rft.au=Ahn%2C+Jiyoung%3BMoslehi%2C+Roxana%3BWeinstein%2C+Stephanie+J%3BSnyder%2C+Kirk%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Ahn&rft.aufirst=Jiyoung&rft.date=2008-09-01&rft.volume=123&rft.issue=5&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23591 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genetics; Age; vitamins; body mass; intervention; micronutrients; prevention; body size; prostate cancer DO - http://dx.doi.org/10.1002/ijc.23591 ER - TY - JOUR T1 - Pilot study of mutant ras peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers AN - 20825423; 8346291 AB - Introduction: There is mounting evidence describing the immunosuppressive role of bulky metastatic disease, thus countering the therapeutic effects of tumor vaccine. Therefore, adjuvant immunotherapy may have a better impact on clinical outcome. In this phase II clinical trial, we aimed to test the feasibility of using a specific mutant ras peptide vaccine as an adjuvant immunotherapy in pancreatic and colorectal cancer patients. Materials and methods: Twelve patients with no evidence of disease (NED), five pancreatic and seven colorectal cancer patients were vaccinated subcutaneously with 13-mer mutant ras peptide, corresponding to their tumor's ras mutation. Vaccinations were given every 4 weeks, up to a total of six vaccines. Results: No serious acute or delayed systemic side effects were seen. We detected specific immune responses to the relevant mutant ras peptide by measuring IFN-gamma mRNA expression by quantitative real-time PCR. Five out of eleven patients showed a positive immune response. Furthermore, the five pancreatic cancer patients have shown a mean disease-free survival (DFS) of 35.2+ months and a mean overall survival (OS) of 44.4+ months. The seven colorectal cancer patients have shown a mean disease-free survival (DFS) of 27.2+ months and a mean overall survival (OS) of 41.5+ months. Conclusion: In this study, we found that it is feasible to use mutant ras vaccine in the adjuvant setting. This vaccine is safe, can induce specific immune responses, and it appears to have a positive outcome in overall survival. Therefore, we believe that such an approach warrants further investigation in combination with other therapies. JF - Cancer Immunology, Immunotherapy AU - Toubaji, Antoun AU - Achtar, Moujahed AU - Provenzano, Maurizio AU - Herrin, Vincent E AU - Behrens, Robert AU - Hamilton, Michael AU - Bernstein, Sarah AU - Venzon, David AU - Gause, Barry AU - Marincola, Francesco AU - Khleif, Samir N AD - NCI, NIH, NNMC, Bldg 8, Room 5101, 8901 Wisconsin Ave, Bethesda, MD, 20889, USA, khleif@nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1413 EP - 1420 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 57 IS - 9 SN - 0340-7004, 0340-7004 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Ras protein KW - Cancer vaccines KW - gamma -Interferon KW - Immunotherapy KW - Colorectal cancer KW - Pancreatic cancer KW - Survival KW - Tumors KW - Adjuvants KW - Clinical trials KW - Gene expression KW - Metastases KW - Polymerase chain reaction KW - Peptides KW - Immune response KW - Mutation KW - Side effects KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20825423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Immunology%2C+Immunotherapy&rft.atitle=Pilot+study+of+mutant+ras+peptide-based+vaccine+as+an+adjuvant+treatment+in+pancreatic+and+colorectal+cancers&rft.au=Toubaji%2C+Antoun%3BAchtar%2C+Moujahed%3BProvenzano%2C+Maurizio%3BHerrin%2C+Vincent+E%3BBehrens%2C+Robert%3BHamilton%2C+Michael%3BBernstein%2C+Sarah%3BVenzon%2C+David%3BGause%2C+Barry%3BMarincola%2C+Francesco%3BKhleif%2C+Samir+N&rft.aulast=Toubaji&rft.aufirst=Antoun&rft.date=2008-09-01&rft.volume=57&rft.issue=9&rft.spage=1413&rft.isbn=&rft.btitle=&rft.title=Cancer+Immunology%2C+Immunotherapy&rft.issn=03407004&rft_id=info:doi/10.1007%2Fs00262-008-0477-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ras protein; gamma -Interferon; Cancer vaccines; Immunotherapy; Pancreatic cancer; Colorectal cancer; Survival; Adjuvants; Tumors; Clinical trials; Metastases; Gene expression; Polymerase chain reaction; Peptides; Immune response; Mutation; Side effects DO - http://dx.doi.org/10.1007/s00262-008-0477-6 ER - TY - JOUR T1 - Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial AN - 20732669; 8408922 AB - Background: Low dietary folate intake has been associated with colorectal cancer risk and adenoma recurrence. A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk. Methods: We investigated the association between MTHFR, total folate, and the risk of colorectal adenoma recurrence in the Polyp Prevention Trial. We compared 625 individuals with any adenoma recurrence after 4 years (266 individuals with multiple ( greater than or equal to 2) recurrent adenomas and 101 individuals with advanced adenoma recurrence) to 978 individuals with no adenoma recurrence. Odds ratios (OR) and 95% confidence intervals (CI) for risk of adenoma recurrence were calculated using unconditional logistic regression. We also investigated effect modification of the MTHFR genotype associations by total folate intake. Results: In general, no statistically significant associations were found between quartile of folate intake (dietary or total) and adenoma recurrence. The MTHFR CT genotype was associated with a significantly increased risk of multiple adenoma recurrence (OR: 1.34, 95% CI: 1.00, 1.81). No significant interaction was noted for total folate and MTHFR genotype, though an increased risk of recurrence noted for the MTHFR CT genotype was statistically significant only for those individuals with below median intake of total folate. Conclusion: We report that the MTHFR 677 CT genotype was associated with increased risk of adenoma recurrence (specifically multiple adenoma recurrence) 4 years after polypectomy. JF - Cancer Causes & Control AU - Murphy, Gwen AU - Sansbury, Leah B AU - Cross, Amanda J AU - Stolzenberg-Solomon, Rachael AU - Laiyemo, Adeyinka AU - Albert, Paul S AU - Wang, Zhuoqiao AU - Schatzkin, Arthur AU - Lehman, Teresa AU - Kalidindi, Aravind AU - Modali, Rama AU - Lanza, Elaine AD - National Cancer Institute, 6120 Executive Blvd., EPS 7067, Rockville, MD, 20892, USA, murphygw@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 751 EP - 758 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 19 IS - 7 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Diets KW - polyps KW - colorectal carcinoma KW - prevention KW - Genotypes KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20732669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Folate+and+MTHFR%3A+risk+of+adenoma+recurrence+in+the+Polyp+Prevention+Trial&rft.au=Murphy%2C+Gwen%3BSansbury%2C+Leah+B%3BCross%2C+Amanda+J%3BStolzenberg-Solomon%2C+Rachael%3BLaiyemo%2C+Adeyinka%3BAlbert%2C+Paul+S%3BWang%2C+Zhuoqiao%3BSchatzkin%2C+Arthur%3BLehman%2C+Teresa%3BKalidindi%2C+Aravind%3BModali%2C+Rama%3BLanza%2C+Elaine&rft.aulast=Murphy&rft.aufirst=Gwen&rft.date=2008-09-01&rft.volume=19&rft.issue=7&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-008-9137-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; polyps; colorectal carcinoma; prevention; Genotypes; Cancer DO - http://dx.doi.org/10.1007/s10552-008-9137-6 ER - TY - JOUR T1 - Aromatic Amine Pesticide Use And Human Cancer Risk: Results From The U.S. Agricultural Health Study AN - 20564603; 9272883 AB - P33. JF - Annals of Epidemiology AU - Koutros, S AU - Lynch, C F AU - Ma, X AU - Lee, W J AU - Hoppin, J A AU - Christensen, C H AU - Andreotti, G AU - Freeman, L Beane AU - Rusiecki, J A AU - Hou, L AU - Sandler, D P AU - Alavanja, MCR AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 720 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 9 SN - 1047-2797, 1047-2797 KW - Risk Abstracts; Health & Safety Science Abstracts KW - USA KW - Pesticides KW - Amines KW - Cancer KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20564603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Aromatic+Amine+Pesticide+Use+And+Human+Cancer+Risk%3A+Results+From+The+U.S.+Agricultural+Health+Study&rft.au=Koutros%2C+S%3BLynch%2C+C+F%3BMa%2C+X%3BLee%2C+W+J%3BHoppin%2C+J+A%3BChristensen%2C+C+H%3BAndreotti%2C+G%3BFreeman%2C+L+Beane%3BRusiecki%2C+J+A%3BHou%2C+L%3BSandler%2C+D+P%3BAlavanja%2C+MCR&rft.aulast=Koutros&rft.aufirst=S&rft.date=2008-09-01&rft.volume=18&rft.issue=9&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2008.08.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Pesticides; Amines; Cancer; USA DO - http://dx.doi.org/10.1016/j.annepidem.2008.08.043 ER - TY - JOUR T1 - Cigarette Smoking And Risk Of Pancreatic Cancer: A Pooled Analysis From The Pancreatic Cancer Cohort Consortium (Panscan) AN - 20561746; 9272881 AB - P31. JF - Annals of Epidemiology AU - Lynch, S M AU - Vrieling, A AU - Lubin, J AU - Kraft, P AU - Hartge, P AU - Bueno-De-Mesquita, H B AU - Stolzenberg-Solomon, R AD - National Cancer Institute, Rockville, MD Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 719 EP - 720 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 9 SN - 1047-2797, 1047-2797 KW - Risk Abstracts KW - pancreatic cancer KW - Cigarette smoking KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20561746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Cigarette+Smoking+And+Risk+Of+Pancreatic+Cancer%3A+A+Pooled+Analysis+From+The+Pancreatic+Cancer+Cohort+Consortium+%28Panscan%29&rft.au=Lynch%2C+S+M%3BVrieling%2C+A%3BLubin%2C+J%3BKraft%2C+P%3BHartge%2C+P%3BBueno-De-Mesquita%2C+H+B%3BStolzenberg-Solomon%2C+R&rft.aulast=Lynch&rft.aufirst=S&rft.date=2008-09-01&rft.volume=18&rft.issue=9&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2008.08.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - pancreatic cancer; Cigarette smoking DO - http://dx.doi.org/10.1016/j.annepidem.2008.08.041 ER - TY - JOUR T1 - Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography AN - 20254499; 8867146 AB - This manuscript reports an approach to the screening of natural product extracts for compounds which are active at membrane-bound receptors, ion channels and transporters. The technique is based upon cellular membrane affinity chromatography (CMAC) columns created through the immobilization of cellular membrane fragments on liquid chromatography stationary phases. In this study a CMAC(nAChR(+)) column was created out of membranes from a transfected cell line expressing the alpha sub(3) beta sub(4) neuronal nicotinic acetylcholine receptor (nAChR) and the column was used to screen tobacco smoke condensates. A strategy involving parallel screening with a CMAC column created from a non-transfected form of the same cell line, CMAC(nAChR(-)) was adopted. The condensate was chromatographed on both columns, timed fractions collected and concentrated. Each fraction was analyzed on a C sub(18) column in order to establish a chromatographic fingerprint of each fraction and a differential elution profile of each compound. Comparison of the elution profiles from the CMAC(nAChR(+)) and CMAC(nAChR(-)) columns identified patterns that could be associated with high affinity ligands and with low- affinity/non-binding compounds. Known strong ligands ((S)-nicotine, (R,S)- anatabine, N'-nitrosonornicotine), weak ligands ((R,S)-nornicotine, anabasine) as well as known non-ligands (N-methyl- gamma -oxo-3- pyridinebutanamide, (1'S,2'S)-nicotine 1'-oxide) have been identified in the complex extract. The results demonstrate that CMAC-based screens can be used in the identification of compounds within natural product extracts that bind to membrane-based targets. JF - Journal of Pharmaceutical and Biomedical Analysis AU - Maciuk, Alexandre AU - Moaddel, Ruin AU - Haginaka, Jun AU - Wainer, Irving W AD - Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, United States, Wainerir@grc.nia.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 238 EP - 246 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 48 IS - 2 SN - 0731-7085, 0731-7085 KW - Toxicology Abstracts KW - Natural products screening KW - alpha sub(3) beta sub(4) Nicotinic receptor KW - Affinity chromatography KW - Nicotine derivatives KW - Tobacco smoke fingerprinting KW - Drug discovery KW - Smoke KW - stationary phase KW - Condensates KW - Liquid chromatography KW - Ion channels KW - Tobacco KW - N'-Nitrosonornicotine KW - natural products KW - Acetylcholine receptors (nicotinic) KW - Immobilization KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20254499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Screening+of+tobacco+smoke+condensate+for+nicotinic+acetylcholine+receptor+ligands+using+cellular+membrane+affinity+chromatography+columns+and+missing+peak+chromatography&rft.au=Maciuk%2C+Alexandre%3BMoaddel%2C+Ruin%3BHaginaka%2C+Jun%3BWainer%2C+Irving+W&rft.aulast=Maciuk&rft.aufirst=Alexandre&rft.date=2008-09-01&rft.volume=48&rft.issue=2&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2007.11.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - stationary phase; Smoke; Affinity chromatography; Condensates; Liquid chromatography; Ion channels; N'-Nitrosonornicotine; Tobacco; natural products; Immobilization; Acetylcholine receptors (nicotinic) DO - http://dx.doi.org/10.1016/j.jpba.2007.11.024 ER - TY - JOUR T1 - The molecular forms of Anopheles gambiae: A phenotypic perspective AN - 20110437; 8580649 AB - The African malaria mosquito Anopheles gambiae is undergoing speciation, being split into the M and S molecular forms. Speciation is the main process promoting biological diversity, thus, new vector species might complicate disease transmission. Genetic differentiation between the molecular forms has been extensively studied, but phenotypic differences between them, the evolutionary forces that generated divergence, and the mechanisms that maintain their genetic isolation have only recently been addressed. Here, we review recent studies suggesting that selection mediated by larval predation and competition promoted divergence between temporary and permanent freshwater habitats. These differences explain the sharp discontinuity in distribution of the molecular forms between rice fields and surrounding savanna, but they can also explain the concurrent cline between humid and arid environments due to the dependence on permanent habitats in the latter. Although less pronounced, differences in adult body size, reproductive output, and longevity also suggest that the molecular forms have adapted to distinct niches. Reproductive isolation between the molecular forms is achieved by spatial swarm segregation, although within-swarm mate recognition appears to play a role in certain locations. The implications of these results to disease transmission and control are discussed and many of the gaps in our understanding are highlighted. JF - Infection, Genetics and Evolution AU - Lehmann, Tovi AU - Diabate, Abdoulaye AD - Laboratory of Malaria and Vector Research, NIAID, NIH, MS 8132, 12735 Twinbrook Parkway, Rockville, MD, USA, tlehmann@niaid.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 737 EP - 746 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 8 IS - 5 SN - 1567-1348, 1567-1348 KW - Ecology Abstracts; Entomology Abstracts; Sustainability Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Anopheles gambiae KW - Malaria KW - Mating behavior KW - Predation KW - Reproductive isolation KW - Divergent selection KW - Ecological speciation KW - Swarm KW - Speciation KW - Niches KW - Arid environments KW - Biological diversity KW - body size KW - Disease transmission KW - Genetics KW - Differentiation KW - Savannahs KW - Clines KW - Rice fields KW - Swarms KW - Body size KW - longevity KW - Competition KW - disease transmission KW - Freshwater environments KW - Larvae KW - Genetic isolation KW - Oryza sativa KW - Vectors KW - Habitat KW - Mate recognition KW - Longevity KW - Deserts KW - malaria KW - Reviews KW - Africa KW - Evolution KW - niches KW - competition KW - G 07790:Other Microorganisms KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies KW - Z 05360:Genetics and Evolution KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20110437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection%2C+Genetics+and+Evolution&rft.atitle=The+molecular+forms+of+Anopheles+gambiae%3A+A+phenotypic+perspective&rft.au=Lehmann%2C+Tovi%3BDiabate%2C+Abdoulaye&rft.aulast=Lehmann&rft.aufirst=Tovi&rft.date=2008-09-01&rft.volume=8&rft.issue=5&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Infection%2C+Genetics+and+Evolution&rft.issn=15671348&rft_id=info:doi/10.1016%2Fj.meegid.2008.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Speciation; Freshwater environments; Niches; Arid environments; Predation; Genetic isolation; Biological diversity; Vectors; Malaria; Mate recognition; Habitat; Longevity; Disease transmission; Savannahs; Differentiation; Clines; Rice fields; Swarms; Reproductive isolation; Reviews; Body size; Competition; Evolution; disease transmission; Larvae; body size; Genetics; Deserts; malaria; longevity; competition; niches; Oryza sativa; Anopheles gambiae; Africa DO - http://dx.doi.org/10.1016/j.meegid.2008.06.003 ER - TY - JOUR T1 - Hepatic Effects among Workers Exposed to Ethylene Glycol Monoethyl Ether Acetate AN - 20060443; 8689760 AB - Data about hepatic effects of ethylene glycol ethers had been limited and inconsistent In this study, we determined whether ethylene glycol monoethyl ether acetate (EGEEA) was a hepatotoxin in exposed workers. Workers from one silk-screening shop (n=29), using EGEEA as the major cleaning solvent, were recruited as high exposure group. Another group of workers with indirect and low exposure to EGEEA (n=57) were selected as the comparison group. Air concentration of EGEEA was measured by 8-h personal sampling. The mean of air EGEEA concentration in the high exposure group was 7.41-16.5 ppm. The mean of air EGEEA concentration in the low exposure group was 0.07-3.62 ppm. Liver function profiles showed that the AST, ALT, ALP and gamma GT in both male and female EGEEA-exposed workers were not significantly different from those in the comparison group. After adjustment for potential con-founders such as gender, body mass index, hepatitis B status, and duration of employment, no difference in hepatic dysfunction were found between exposed and comparison groups. In addition, a two-year follow-up study of these EGEEA-exposed workers, no significant change in hepatic function was noted either. The findings suggest that EGEEA is not a hepatotoxin in this workplace. JF - Industrial Health AU - Loh, C-H AU - Liou, S-H AU - Jiau, S-S AU - Cheng, W-T AU - Shih, T-S AU - Chen, H-I AD - Department of Family Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Rd, Sec. 2, Nei-Hu, Taipei, Taiwan 114, ROC Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 463 EP - 469 VL - 46 IS - 5 SN - 0019-8366, 0019-8366 KW - Virology & AIDS Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - employment KW - Data processing KW - Solvents KW - hepatitis B KW - Acetic acid KW - Workers KW - body mass KW - Gender KW - Liver KW - Hepatitis B KW - Ethers KW - Ethylene glycol KW - Sampling KW - Body mass index KW - Occupational exposure KW - V 22490:Miscellaneous KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20060443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Hepatic+Effects+among+Workers+Exposed+to+Ethylene+Glycol+Monoethyl+Ether+Acetate&rft.au=Loh%2C+C-H%3BLiou%2C+S-H%3BJiau%2C+S-S%3BCheng%2C+W-T%3BShih%2C+T-S%3BChen%2C+H-I&rft.aulast=Loh&rft.aufirst=C-H&rft.date=2008-09-01&rft.volume=46&rft.issue=5&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Workers; Data processing; Hepatitis B; Solvents; Liver; Sampling; Ethylene glycol; Ethers; Body mass index; Acetic acid; Occupational exposure; employment; body mass; Gender; hepatitis B ER - TY - JOUR T1 - Mutational study of the "catalytic tetrad" of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance AN - 20057247; 8844401 AB - Leishmania donovani, the causative organism for visceral leishmaniasis, contains a unique bisubunit DNA-topoisomerase IB (LdTopIB). The catalytically active enzyme is a heterodimer constituted by a large subunit (LdTopIL) containing a non-conserved N-terminal end and the phylogenetically conserved core domain, whereas the small subunit (LdTopIS) harbors the C-terminal domain with the characteristic tyrosine residue in the active site. Site-directed mutagenesis was used to substitute the basic amino acid (Arg-314, Lys-352, Arg-410 and His-453) of the LdTopIL subunit by the neutral amino acid alanine. The expression of these mutants in a topoisomerase-free yeast strain produced inactive proteins. Similarly, when the Tyr-222 from small subunit, involved in DNA cleavage, was substituted by Phe no topoisomerase activity was detected in yeast overexpressing extracts. In addition two substitutions involved in camptothecin inhibition were also analyzed. Asp-353 located in the core domain of the large subunit and Asn-221 which heads Tyr-222 in the small subunit, were replaced by Ala and Ser, respectively. These mutants were insensitive to the inhibitor; despite they displayed significant relaxation activity. JF - Biochemical Pharmacology AU - Diaz-Gonzalez, Rosario AU - Perez-Pertejo, Yolanda AU - Pommier, Yves AU - Balana-Fouce, Rafael AU - Reguera, Rosa M AD - Departamento de Farmacologia y Toxicologia (INTOXCAL), Universidad de Leon, Campus de Vegazana s/n, 24071 Leon, Spain, pommier@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 608 EP - 619 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 76 IS - 5 SN - 0006-2952, 0006-2952 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Topoisomerase IB KW - Leishmania KW - Trypanosomatids KW - Camptothecin KW - Site-directed mutagenesis KW - Tropical diseases KW - Phylogeny KW - Amino acids KW - Alanine KW - Visceral leishmaniasis KW - DNA topoisomerase KW - Enzymes KW - Tyrosine KW - Leishmania donovani KW - Heads KW - DNA KW - Tetrads KW - K 03340:Effects of Physical & Chemical Factors KW - N 14835:Protein-Nucleic Acids Association KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20057247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Mutational+study+of+the+%22catalytic+tetrad%22+of+DNA+topoisomerase+IB+from+the+hemoflagellate+Leishmania+donovani%3A+Role+of+Asp-353+and+Asn-221+in+camptothecin+resistance&rft.au=Diaz-Gonzalez%2C+Rosario%3BPerez-Pertejo%2C+Yolanda%3BPommier%2C+Yves%3BBalana-Fouce%2C+Rafael%3BReguera%2C+Rosa+M&rft.aulast=Diaz-Gonzalez&rft.aufirst=Rosario&rft.date=2008-09-01&rft.volume=76&rft.issue=5&rft.spage=608&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/10.1016%2Fj.bcp.2008.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Site-directed mutagenesis; Heads; Phylogeny; Amino acids; Alanine; Visceral leishmaniasis; DNA; DNA topoisomerase; Tyrosine; Enzymes; Tetrads; Camptothecin; Leishmania donovani DO - http://dx.doi.org/10.1016/j.bcp.2008.06.019 ER - TY - JOUR T1 - Type III Secretion Decreases Bacterial and Host Survival following Phagocytosis of Yersinia pseudotuberculosis by Macrophages AN - 20039139; 8406444 AB - Yersinia pseudotuberculosis uses a plasmid (pYV)-encoded type III secretion system (T3SS) to translocate a set of effectors called Yops into infected host cells. YopJ functions to induce apoptosis, and YopT, YopE, and YopH act to antagonize phagocytosis in macrophages. Because Yops do not completely block phagocytosis and Y. pseudotuberculosis can replicate in macrophages, it is important to determine if the T3SS modulates host responses to intracellular bacteria. Isogenic pYV-cured, pYV super(+) wild-type, and yop mutant Y. pseudotuberculosis strains were allowed to infect bone marrow-derived murine macrophages at a low multiplicity of infection under conditions in which the survival of extracellular bacteria was prevented. Phagocytosis, the intracellular survival of the bacteria, and the apoptosis of the infected macrophages were analyzed. Forty percent of cell-associated wild-type bacteria were intracellular after a 20-min infection, allowing the study of the macrophage response to internalized pYV super(+) Y. pseudotuberculosis. Interestingly, macrophages restricted survival of pYV super(+) but not pYV-cured or yopB Y. pseudotuberculosis within phagosomes: only a small fraction of the pYV super(+) bacteria internalized replicated by 24 h. In addition, 620% of macrophages infected with wild-type pYV super(+) Y. pseudotuberculosis died of apoptosis after 20 h. Analysis of yop mutants expressing catalytically inactive effectors revealed that YopJ was important for apoptosis, while a role for YopE, YopH, and YopT in modulating macrophage responses to intracellular bacteria could not be identified. Apoptosis was reduced in Toll-like receptor 4-deficient macrophages, indicating that cell death required signaling through this receptor. Treatment of macrophages harboring intracellular pYV super(+) Y. pseudotuberculosis with chloramphenicol reduced apoptosis, indicating that the de novo bacterial protein synthesis was necessary for cell death. Our finding that the presence of a functional T3SS impacts the survival of both bacterium and host following phagocytosis of Y. pseudotuberculosis suggests new roles for the T3SS in Yersinia pathogenesis. JF - Infection and Immunity AU - Zhang, Yue AU - Murtha, James AU - Roberts, Margaret A AU - Siegel, Richard M AU - Bliska, James B AD - Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, SUNY Stony Brook, Stony Brook, New York 11794-5222. Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 4299 EP - 4310 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 9 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Macrophages KW - Bacteria KW - Chloramphenicol KW - Protein biosynthesis KW - Apoptosis KW - Phagosomes KW - Bone marrow KW - Yersinia pseudotuberculosis KW - Plasmids KW - Yersinia KW - Multiplicity of infection KW - Phagocytosis KW - Pseudotuberculosis KW - Toll-like receptors KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20039139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Type+III+Secretion+Decreases+Bacterial+and+Host+Survival+following+Phagocytosis+of+Yersinia+pseudotuberculosis+by+Macrophages&rft.au=Zhang%2C+Yue%3BMurtha%2C+James%3BRoberts%2C+Margaret+A%3BSiegel%2C+Richard+M%3BBliska%2C+James+B&rft.aulast=Zhang&rft.aufirst=Yue&rft.date=2008-09-01&rft.volume=76&rft.issue=9&rft.spage=4299&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell survival; Chloramphenicol; Apoptosis; Protein biosynthesis; Phagosomes; Bone marrow; Plasmids; Pseudotuberculosis; Phagocytosis; Multiplicity of infection; Toll-like receptors; Signal transduction; Bacteria; Yersinia pseudotuberculosis; Yersinia ER - TY - JOUR T1 - Soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: modulation by infection and inflammation AN - 19895154; 8496394 AB - Objective: The receptor for advanced glycation end products (RAGE) has been proposed to participate in the innate and adaptive immune responses. RAGE can induce production of pro-inflammatory cytokines and chemokines, as well as neutrophil chemotaxis in a manner that may be suppressed or stimulated by soluble, truncated forms of RAGE including the soluble form of RAGE (sRAGE) and endogenous secretory RAGE (esRAGE). The objective of this study was to determine whether intra-amniotic infection/inflammation (IAI) is associated with changes in the amniotic fluid concentration of sRAGE and esRAGE.Study design: Amniotic fluid (AF) was retrieved from patients in the following groups: 1) mid-trimester (14a18 weeks of gestation; n=68); 2) term not in labor (n=24); 3) term in labor (n=51); 4) preterm labor and intact membranes (n=124); and 5) preterm PROM (n=80). Intra-amniotic infection and inflammation were defined as the presence of a positive amniotic fluid culture for microorganisms and an AF interleukin-6 concentration aY2.6ANBng/mL, respectively. The AF concentration of sRAGE and esRAGE were determined using specific and sensitive ELISAs which measured total immunoreactive sRAGE and esRAGE, respectively. Patients were matched for gestational age at amniocentesis to compare the AF concentration of sRAGE and esRAGE in patients with and without IAI. Non-parametric statistics were used for analysis and a P&0.05 was considered significant.Results: 1) Patients at term not in labor had higher median AF concentrations of sRAGE and esRAGE than those in the mid-trimester (P&0.001 for both comparisons) and those at term in labor (P=0.03 and P=0.04, respectively); 2) patients with preterm labor and intact membranes with intra-amniotic infection/inflammation (IAI) had higher median AF concentrations of sRAGE and esRAGE than those without IAI (P=0.02 and P=0.005, respectively); 3) similarly, patients with preterm PROM with IAI had higher median AF concentrations of sRAGE and esRAGE than those without IAI (P=0.03 and P=0.02, respectively).Conclusion: Intra-amniotic infection/inflammation is associated with increased amniotic fluid concentrations of sRAGE and esRAGE. Changes in the amniotic fluid concentration of sRAGE and esRAGE may represent part of the immune response to intra-amniotic infection/inflammation. JF - Journal of Perinatal Medicine AU - Romero, Roberto AU - Espinoza, Jimmy AU - Hassan, Sonia AU - Gotsch, Francesca AU - Kusanovic, Juan Pedro AU - Avila, Cecilia AU - Erez, Offer AU - Edwin, Sam AU - Schmidt, Ann Marie AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland, and Detroit, MI, USA and Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA, prbchiefstaff@med.wayne.edu Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 388 EP - 398 PB - Walter de Gruyter und Co., Genthiner Str. 13 VL - 36 IS - 5 SN - 0300-5577, 0300-5577 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Amniotic fluid KW - chorioamnionitis KW - intra-amniotic infection/inflammation KW - MIAC KW - microbial invasion of the amniotic cavity KW - preterm labor KW - preterm PROM KW - preterm delivery KW - Interleukin 6 KW - Chemokines KW - Enzyme-linked immunosorbent assay KW - Gestational age KW - Advanced glycosylation end products KW - Statistical analysis KW - Leukocytes (neutrophilic) KW - Infection KW - Chemotaxis KW - Inflammation KW - Amniocentesis KW - Microorganisms KW - Cytokines KW - Immune response KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Perinatal+Medicine&rft.atitle=Soluble+receptor+for+advanced+glycation+end+products+%28sRAGE%29+and+endogenous+secretory+RAGE+%28esRAGE%29+in+amniotic+fluid%3A+modulation+by+infection+and+inflammation&rft.au=Romero%2C+Roberto%3BEspinoza%2C+Jimmy%3BHassan%2C+Sonia%3BGotsch%2C+Francesca%3BKusanovic%2C+Juan+Pedro%3BAvila%2C+Cecilia%3BErez%2C+Offer%3BEdwin%2C+Sam%3BSchmidt%2C+Ann+Marie&rft.aulast=Romero&rft.aufirst=Roberto&rft.date=2008-09-01&rft.volume=36&rft.issue=5&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Journal+of+Perinatal+Medicine&rft.issn=03005577&rft_id=info:doi/10.1515%2FJPM.2008.076 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Amniotic fluid; Interleukin 6; Enzyme-linked immunosorbent assay; Chemokines; Gestational age; Advanced glycosylation end products; Leukocytes (neutrophilic); Statistical analysis; Infection; Chemotaxis; Inflammation; Amniocentesis; Microorganisms; Cytokines; Immune response DO - http://dx.doi.org/10.1515/JPM.2008.076 ER - TY - JOUR T1 - Identification of Neural Crest and Glial Enhancers at the Mouse Sox10 Locus through Transgenesis in Zebrafish AN - 19887737; 8731358 AB - Sox10 is a dynamically regulated transcription factor gene that is essential for the development of neural crest-derived and oligodendroglial populations. Developmental genes often require multiple regulatory sequences that integrate discrete and overlapping functions to coordinate their expression. To identify Sox10 cis-regulatory elements, we integrated multiple model systems, including cell-based screens and transposon-mediated transgensis in zebrafish, to scrutinize mammalian conserved, noncoding genomic segments at the mouse Sox10 locus. We demonstrate that eight of 11 Sox10 genomic elements direct reporter gene expression in transgenic zebrafish similar to patterns observed in transgenic mice, despite an absence of observable sequence conservation between mice and zebrafish. Multiple segments direct expression in overlapping populations of neural crest derivatives and glial cells, ranging from pan-Sox10 and pan-neural crest regulatory control to the modulation of expression in subpopulations of Sox10-expressing cells, including developing melanocytes and Schwann cells. Several sequences demonstrate overlapping spatial control, yet direct expression in incompletely overlapping developmental intervals. We were able to partially explain neural crest expression patterns by the presence of head to head SoxE family binding sites within two of the elements. Moreover, we were able to use this transcription factor binding site signature to identify the corresponding zebrafish enhancers in the absence of overall sequence homology. We demonstrate the utility of zebrafish transgenesis as a high-fidelity surrogate in the dissection of mammalian gene regulation, especially those with dynamically controlled developmental expression. Author Summary The neural crest is a population of embryonic migratory stem cells. They form atop the future spinal cord and migrate throughout developing embryos and form many different cells, including the epidermal pigment cells, bone cells in the head, and nerve cells of the peripheral nervous system. In this study, we studied the genome elements responsible for expression of SOX10, a dynamically expressed gene that is essential for neural crest development. We isolated candidate regulatory elements for SOX10 by identifying the small percentage of genomic DNA around the gene that did not vary as avian and mammalian genomes changed though evolution. We tested these fragments for their ability to regulate gene expression in zebrafish, a model system that is highly efficient for DNA-mediated expression studies and embryology. We found that even though the genome sequences were not similar to the SOX10 gene in fish, the genomic fragments were able to recapitulate the dynamic expression of SOX10 during development. Through computational analysis of the sequences, we identified a transcription factor binding site signature that identified the corresponding zebrafish SOX10 regulatory elements. This study describes a paradigm for dissecting regulation of essential genes that display complex expression patterns during development. JF - PLoS Genetics AU - Antonellis, Anthony AU - Huynh, Jimmy L AU - Lee-Lin, Shih-Queen AU - Vinton, Ryan M AU - Renaud, Gabriel AU - Loftus, Stacie K AU - Elliot, Gene AU - Wolfsberg, Tyra G AU - Green, Eric D AU - McCallion, Andrew S AU - Pavan, William J AU - Barsh, Gregory S AD - Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 4 IS - 9 SN - 1553-7390, 1553-7390 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Genetics Abstracts KW - Genomes KW - Spinal cord KW - Glial cells KW - Schwann cells KW - Melanocytes KW - Sox10 protein KW - Stem cells KW - Embryo cells KW - Pigments KW - Peripheral nervous system KW - Embryos KW - genomics KW - Cell migration KW - Evolutionary genetics KW - Neuronal-glial interactions KW - Embryology KW - Neural crest KW - Regulatory sequences KW - Transcription KW - Developmental stages KW - Computer applications KW - Transgenic mice KW - Bone KW - Danio rerio KW - Enhancers KW - Homology KW - Reporter gene KW - Transcription factors KW - Gene regulation KW - DNA KW - Evolution KW - W 30925:Genetic Engineering KW - N3 11023:Neurogenetics KW - N 14835:Protein-Nucleic Acids Association KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19887737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Genetics&rft.atitle=Identification+of+Neural+Crest+and+Glial+Enhancers+at+the+Mouse+Sox10+Locus+through+Transgenesis+in+Zebrafish&rft.au=Antonellis%2C+Anthony%3BHuynh%2C+Jimmy+L%3BLee-Lin%2C+Shih-Queen%3BVinton%2C+Ryan+M%3BRenaud%2C+Gabriel%3BLoftus%2C+Stacie+K%3BElliot%2C+Gene%3BWolfsberg%2C+Tyra+G%3BGreen%2C+Eric+D%3BMcCallion%2C+Andrew+S%3BPavan%2C+William+J%3BBarsh%2C+Gregory+S&rft.aulast=Antonellis&rft.aufirst=Anthony&rft.date=2008-09-01&rft.volume=4&rft.issue=9&rft.spage=e1000174&rft.isbn=&rft.btitle=&rft.title=PLoS+Genetics&rft.issn=15537390&rft_id=info:doi/10.1371%2Fjournal.pgen.1000174 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Spinal cord; Glial cells; Schwann cells; Melanocytes; Sox10 protein; Stem cells; Embryo cells; Pigments; Peripheral nervous system; Embryos; Evolutionary genetics; Cell migration; genomics; Neuronal-glial interactions; Neural crest; Embryology; Regulatory sequences; Developmental stages; Transcription; Transgenic mice; Computer applications; Bone; Enhancers; Homology; Reporter gene; Gene regulation; Transcription factors; DNA; Evolution; Danio rerio DO - http://dx.doi.org/10.1371/journal.pgen.1000174 ER - TY - JOUR T1 - The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure AN - 19883854; 8740834 AB - Plasmodium falciparum malaria parasites, living in red blood cells, express proteins of the erythrocyte membrane protein-1 (PfEMP1) family on the red blood cell surface. The binding of PfEMP1 molecules to human cell surface receptors mediates the adherence of infected red blood cells to human tissues. The sequences of the 60 PfEMP1 genes in each parasite genome vary greatly from parasite to parasite, yet the variant PfEMP1 proteins maintain receptor binding. Almost all parasites isolated directly from patients bind the human CD36 receptor. Of the several kinds of highly polymorphic cysteine-rich interdomain region (CIDR) domains classified by sequence, only the CIDR1 alpha domains bind CD36. Here we describe the CD36-binding portion of a CIDR1 alpha domain, MC179, as a bundle of three alpha -helices that are connected by a loop and three additional helices. The MC179 structure, containing seven conserved cysteines and 10 conserved hydrophobic residues, predicts similar structures for the hundreds of CIDR sequences from the many genome sequences now known. Comparison of MC179 with the CIDR domains in the genome of the P. falciparum 3D7 strain provides insights into CIDR domain structure. The CIDR1 alpha three-helix bundle exhibits less than 20% sequence identity with the three-helix bundles of Duffy-binding like (DBL) domains, but the two kinds of bundles are almost identical. Despite the enormous diversity of PfEMP1 sequences, the CIDR1 alpha and DBL protein structures, taken together, predict that a PfEMP1 molecule is a polymer of three-helix bundles elaborated by a variety of connecting helices and loops. From the structures also comes the insight that DBL1 alpha domains are approximately 100 residues larger and that CIDR1 alpha domains are approximately 100 residues smaller than sequence alignments predict. This new understanding of PfEMP1 structure will allow the use of better-defined PfEMP1 domains for functional studies, for the design of candidate vaccines, and for understanding the molecular basis of cytoadherence. Author Summary Malaria parasites express proteins of the erythrocyte membrane protein-1 family (PfEMP1) on the surfaces of the human red blood cells that they infect. These large proteins vary in sequence extensively, yet bind to host receptors to allow infected cells to adhere to host tissues. PfEMP1 proteins help parasites evade the immune system, as the 60 PfEMP1 genes are expressed one at a time. Sequence comparisons predict that PfEMP1 molecules are modular, made up of Duffy binding-like (DBL) and cysteine-rich interdomain region (CIDR) domains. Many CIDR domains bind to the human receptor CD36. We have analyzed the structure of the CD36-binding portion, known as MC179, of a CIDR domain. The MC179 protein is composed of a bundle of three helices connected by a loop and three additional helices. Based on the structure and sequence similarities, MC179 is a good model for the hundreds of known CIDR sequences. In addition, the MC179 three-helix bundle is remarkably similar to subdomain 3 of the known DBL structures. MC179 provides insight into the relatedness of both kinds of PfEMP1 domains and predicts that the large PfEMP1 molecules are polymers of three-helix bundles and their connecting polypeptides. JF - PLoS Pathogens AU - Klein, Michael M AU - Gittis, Apostolos G AU - Su, Hua-Poo AU - Makobongo, Morris O AU - Moore, Jaime M AU - Singh, Sanjay AU - Miller, Louis H AU - Garboczi, David N AU - Deitsch, Kirk AD - Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 4 IS - 9 SN - 1553-7366, 1553-7366 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Phylogeny KW - Genomes KW - Cell surface KW - Parasites KW - Human diseases KW - CD36 antigen KW - Immune system KW - Dbl protein KW - Nucleotide sequence KW - Erythrocytes KW - Receptors KW - Hydrophobicity KW - Malaria KW - Plasmodium falciparum KW - Pathogens KW - Public health KW - Cysteine KW - Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - N 14845:Miscellaneous KW - G 07730:Development & Cell Cycle KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19883854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=The+Cysteine-Rich+Interdomain+Region+from+the+Highly+Variable+Plasmodium+falciparum+Erythrocyte+Membrane+Protein-1+Exhibits+a+Conserved+Structure&rft.au=Klein%2C+Michael+M%3BGittis%2C+Apostolos+G%3BSu%2C+Hua-Poo%3BMakobongo%2C+Morris+O%3BMoore%2C+Jaime+M%3BSingh%2C+Sanjay%3BMiller%2C+Louis+H%3BGarboczi%2C+David+N%3BDeitsch%2C+Kirk&rft.aulast=Klein&rft.aufirst=Michael&rft.date=2008-09-01&rft.volume=4&rft.issue=9&rft.spage=e1000147&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1000147 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Genomes; Phylogeny; Parasites; Human diseases; Nucleotide sequence; Erythrocytes; Receptors; Malaria; Public health; Cell surface; CD36 antigen; Dbl protein; Immune system; Hydrophobicity; Pathogens; Cysteine; Vaccines; Plasmodium falciparum DO - http://dx.doi.org/10.1371/journal.ppat.1000147 ER - TY - JOUR T1 - Variation in the Major Surface Glycoprotein Genes in Pneumocystis jirovecii AN - 19807513; 8678463 AB - The genome of Pneumocystis, which causes life-threatening pneumonia in immunosuppressed patients, contains a multicopy gene family that encodes the major surface glycoprotein (Msg). Pneumocystis can vary the expressed Msg, presumably as a mechanism to avoid host immune responses. Analysis of 24 msg-gene sequences obtained from a single human isolate of Pneumocystis demonstrated that the sequences segregate into 2 branches. Results of a number of analyses suggest that recombination between msg genes is an important mechanism for generating msg diversity. Intrabranch recombination occurred more frequently than interbranch recombination. Restriction-fragment length polymorphism analysis of human isolates of Pneumocystis demonstrated substantial variation in the repertoire of the msg-gene family, variation that was not observed in laboratory isolates of Pneumocystis in rats or mice; this may be the result of examining outbred versus captive populations. Increased diversity in the Msg repertoire, generated in part by recombination. Increases the potential for antigenic variation in this abundant surface protein. JF - Journal of Infectious Diseases AU - Kutty, G AU - Maidarelli, F AU - Achaz, G AU - Kovacs, JA AD - Bldg. 10, Rm. 2C145, MSC 1662, Bethesda, MD 20892-1662, USA, jkovacs@nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 741 EP - 749 VL - 198 IS - 5 SN - 0022-1899, 0022-1899 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Genomes KW - Recombination KW - Pneumocystis KW - Glycoproteins KW - Pneumonia KW - G 07790:Other Microorganisms KW - K 03400:Human Diseases KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19807513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Variation+in+the+Major+Surface+Glycoprotein+Genes+in+Pneumocystis+jirovecii&rft.au=Kutty%2C+G%3BMaidarelli%2C+F%3BAchaz%2C+G%3BKovacs%2C+JA&rft.aulast=Kutty&rft.aufirst=G&rft.date=2008-09-01&rft.volume=198&rft.issue=5&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F590433 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Recombination; Glycoproteins; Pneumonia; Pneumocystis DO - http://dx.doi.org/10.1086/590433 ER - TY - JOUR T1 - Liver is a Target of Arsenic Carcinogenesis AN - 19795612; 8408077 AB - Inorganic arsenic is clearly a human carcinogen causing tumors of the skin, lung, urinary bladder, and possibly liver (IARC, 2004). At the time of construction of this monograph, the evidence for arsenic as a hepatocarcinogen in humans was considered controversial and in rodents considered insufficient. However, recent data has accumulated indicating hepatocarcinogenicity of arsenic. This forum reevaluates epidemiology studies, rodent studies together with in vitro models, and focuses on the liver as a target organ of arsenic toxicity and carcinogenesis. Hepatocellular carcinoma and hepatic angiosarcoma, have been frequently associated with environmental or medicinal exposure to arsenicals. Preneoplastic lesions, including hepatomegaly, hepatoportal sclerosis, fibrosis, and cirrhosis often occur after chronic arsenic exposure. Recent work in mice clearly shows that exposure to inorganic arsenic during gestation induces tumors, including hepatocellular adenoma and carcinoma, in offspring when they reach adulthood. In rats, the methylated arsenicals, dimethylarsinic acid promotes diethylnitrosamine-initiated liver tumors, whereas trimethylarsine oxide induces liver adenomas. Chronic exposure of rat liver epithelial cells to low concentrations of inorganic arsenic induces malignant transformation, producing aggressive, undifferentiated epithelial tumors when inoculated into the Nude mice. There are a variety of potential mechanisms for arsenical-induced hepatocarcinogenesis, such as oxidative DNA damage, impaired DNA damage repair, acquired apoptotic tolerance, hyperproliferation, altered DNA methylation, and aberrant estrogen signaling. Some of these mechanisms may be liver specific/selective. Overall, accumulating evidence clearly indicates that the liver could be an important target of arsenic carcinogenesis. JF - Fundamental and Applied Toxicology AU - Liu, Jie AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 24 EP - 32 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 105 IS - 1 SN - 0272-0590, 0272-0590 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Transformation KW - Epithelial cells KW - Apoptosis KW - Hepatocytes KW - Fibrosis KW - Animal models KW - Carcinogens KW - Chronic exposure KW - Gestation KW - DNA methylation KW - oxides KW - dimethylarsinic acid KW - Hepatocellular carcinoma KW - Estrogens KW - Arsenic KW - Data processing KW - Cirrhosis KW - Skin KW - Urinary bladder KW - Sclerosis KW - Tumors KW - Toxicity KW - DNA damage KW - Epidemiology KW - Lung KW - Carcinogenesis KW - Progeny KW - Adenoma KW - Signal transduction KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19795612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fundamental+and+Applied+Toxicology&rft.atitle=Liver+is+a+Target+of+Arsenic+Carcinogenesis&rft.au=Liu%2C+Jie%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2008-09-01&rft.volume=105&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Fundamental+and+Applied+Toxicology&rft.issn=02720590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transformation; Epithelial cells; Apoptosis; Fibrosis; Hepatocytes; Animal models; Carcinogens; Chronic exposure; Gestation; DNA methylation; oxides; dimethylarsinic acid; Hepatocellular carcinoma; Arsenic; Estrogens; Skin; Cirrhosis; Data processing; Urinary bladder; Sclerosis; Toxicity; Tumors; DNA damage; Epidemiology; Lung; Carcinogenesis; Progeny; Adenoma; Signal transduction ER - TY - JOUR T1 - Selective A sub(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system AN - 19721271; 8808626 AB - We have prepared 5'-modified derivatives of adenosine and a corresponding (N)-methanocarba nucleoside series containing a bicyclo[3.1.0]hexane ring system in place of the ribose moiety. The compounds were examined in binding assays at three subtypes of adenosine receptors (ARs) and in functional assays at the A sub(3) AR. The H-bonding ability of a group of 9-riboside derivatives containing a 5'-uronamide moiety was reduced by modification of the NH; however these derivatives did not display the desired activity as selective A sub(3) AR antagonists, as occurs with 5'-N,N-dimethyluronamides. However, truncated (N)- methanocarba analogues lacking a 4'-hydroxymethyl group were highly potent and selective antagonists of the human A sub(3) AR. The compounds were synthesized from d-ribose using a reductive free radical decarboxylation of a 5'-carboxy intermediate. A less efficient synthetic approach began with L-ribose, which was similar to the published synthesis of (N)-methanocarba A sub(3)AR agonists. Compounds 33b- 39b (N super(6)-3-halobenzyl and related arylalkyl derivatives) were potent A sub(3)AR antagonists with binding K sub(i) values of 0.7- 1.4 nM. In a functional assay of [ super(35)S]GTP gamma S binding, 33b (3-iodobenzyl) completely inhibited stimulation by NECA with a K sub(B) of 8.9 nM. Thus, a highly potent and selective series of A sub(3)AR antagonists has been described. JF - Bioorganic and Medicinal Chemistry AU - Melman, Artem AU - Wang, Ben AU - Joshi, Bhalchandra V AU - Gao, Zhan-Guo AU - De Castro, Sonia AU - Heller, Cara L AU - Kim, Soo-Kyung AU - Jeong, Lak Shin AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8A, Room B1A-19, Bethesda, MD 20892, USA, kajacobs@helix.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 8546 EP - 8556 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 18 SN - 0968-0896, 0968-0896 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - D-Ribose KW - Adenosine receptors KW - Free radicals KW - nucleosides KW - Ribose KW - Antagonists KW - Decarboxylation KW - N 14840:Antisense, Nucleotide Analogs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19721271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Selective+A+sub%283%29+adenosine+receptor+antagonists+derived+from+nucleosides+containing+a+bicyclo%5B3.1.0%5Dhexane+ring+system&rft.au=Melman%2C+Artem%3BWang%2C+Ben%3BJoshi%2C+Bhalchandra+V%3BGao%2C+Zhan-Guo%3BDe+Castro%2C+Sonia%3BHeller%2C+Cara+L%3BKim%2C+Soo-Kyung%3BJeong%2C+Lak+Shin%3BJacobson%2C+Kenneth+A&rft.aulast=Melman&rft.aufirst=Artem&rft.date=2008-09-01&rft.volume=16&rft.issue=18&rft.spage=8546&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.08.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - D-Ribose; Adenosine receptors; Free radicals; Ribose; nucleosides; Decarboxylation; Antagonists DO - http://dx.doi.org/10.1016/j.bmc.2008.08.007 ER - TY - JOUR T1 - Unraveling transcriptional regulatory programs by integrative analysis of microarray and transcription factor binding data AN - 19715938; 8523660 AB - Motivation: Unraveling the transcriptional regulatory program mediated by transcription factors (TFs) is a fundamental objective of computational biology, yet still remains a challenge. Method: Here, we present a new methodology that integrates microarray and TF binding data for unraveling transcriptional regulatory networks. The algorithm is based on a two-stage constrained matrix decomposition model. The model takes into account the non-linear structure in gene expression data, particularly in the TF-target gene interactions and the combinatorial nature of gene regulation by TFs. The gene expression profile is modeled as a linear weighted combination of the activity profiles of a set of TFs. The TF activity profiles are deduced from the expression levels of TF target genes, instead directly from TFs themselves. The TF-target gene relationships are derived from ChIP-chip and other TF binding data. The proposed algorithm can not only identify transcriptional modules, but also reveal regulatory programs of which TFs control which target genes in which specific ways (either activating or inhibiting). Results: In comparison with other methods, our algorithm identifies biologically more meaningful transcriptional modules relating to specific TFs. We applied the new algorithm on yeast cell cycle and stress response data. While known transcriptional regulations were confirmed, novel TF-gene interactions were predicted and provide new insights into the regulatory mechanisms of the cell. Supplementary information: Supplementary data are available at Bioinformatics online. JF - Computer Applications in the Biosciences AU - Li, Huai AU - Zhan, Ming AD - Bioinformatics Unit, Branch of Research Resources, National Institute on Aging, NIH, Baltimore, MD 21224, USA, zhanmi@mail.nih.gov Y1 - 2008/09/01/ PY - 2008 DA - 2008 Sep 01 SP - 1874 EP - 1880 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 24 IS - 17 SN - 0266-7061, 0266-7061 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - Transcription factors KW - Gene regulation KW - Cell cycle KW - Algorithms KW - Bioinformatics KW - Computer applications KW - DNA microarrays KW - Decomposition KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19715938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Applications+in+the+Biosciences&rft.atitle=Unraveling+transcriptional+regulatory+programs+by+integrative+analysis+of+microarray+and+transcription+factor+binding+data&rft.au=Li%2C+Huai%3BZhan%2C+Ming&rft.aulast=Li&rft.aufirst=Huai&rft.date=2008-09-01&rft.volume=24&rft.issue=17&rft.spage=1874&rft.isbn=&rft.btitle=&rft.title=Computer+Applications+in+the+Biosciences&rft.issn=02667061&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn332 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Gene regulation; Transcription factors; Cell cycle; Algorithms; Bioinformatics; Computer applications; Decomposition; DNA microarrays DO - http://dx.doi.org/10.1093/bioinformatics/btn332 ER - TY - JOUR T1 - Trans-natural antisense transcripts including noncoding RNAs in 10 species: implications for expression regulation AN - 19711613; 8523957 AB - Natural antisense transcripts are at least partially complementary to their sense transcripts. Cis-Sense/Antisense pairs (cis-SAs) have been extensively characterized and known to play diverse regulatory roles, whereas trans-Sense/Antisense pairs (trans-SAs) in animals are poorly studied. We identified long trans-SAs in human and nine other animals, using ESTs to increase coverage significantly over previous studies. The percentage of transcriptional units (TUs) involved in trans-SAs among all TUs was as high as 4.13%. Particularly 2896 human TUs (or 2.89% of all human TUs) were involved in 3327 trans-SAs. Sequence complementarities over multiple segments with predicted RNA hybridization indicated that some trans-SAs might have sophisticated RNA-RNA pairing patterns. One-fourth of human trans-SAs involved noncoding TUs, suggesting that many noncoding RNAs may function by a trans-acting antisense mechanism. TUs in trans-SAs were statistically significantly enriched in nucleic acid binding, ion/protein binding and transport and signal transduction functions and pathways; a significant number of human trans-SAs showed concordant or reciprocal expression pattern; a significant number of human trans-SAs were conserved in mouse. This evidence suggests important regulatory functions of trans-SAs. In 30 cases, trans-SAs were related to cis-SAs through paralogues, suggesting a possible mechanism for the origin of trans-SAs. All trans-SAs are available at http://trans.cbi.pku.edu.cn/ . JF - Nucleic Acids Research AU - Li, Jiong-Tang AU - Zhang, Yong AU - Kong, Lei AU - Liu, Qing-Rong AU - Wei, Liping AD - super(1)Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing, 100871, P.R. China and super(2)Department of Health and Human Services (DHHS), Molecular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program (NIDA-IRP), NIH, Box 5180, Baltimore, MD 21224, USA Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 4833 EP - 4844 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - 15 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Protein transport KW - Antisense KW - nucleic acids KW - RNA KW - Nucleotide sequence KW - Transcription KW - Proteins KW - expressed sequence tags KW - Complementarity KW - Signal transduction KW - W 30940:Products KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Trans-natural+antisense+transcripts+including+noncoding+RNAs+in+10+species%3A+implications+for+expression+regulation&rft.au=Li%2C+Jiong-Tang%3BZhang%2C+Yong%3BKong%2C+Lei%3BLiu%2C+Qing-Rong%3BWei%2C+Liping&rft.aulast=Li&rft.aufirst=Jiong-Tang&rft.date=2008-09-01&rft.volume=36&rft.issue=15&rft.spage=4833&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn470 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein transport; Antisense; nucleic acids; RNA; Nucleotide sequence; Proteins; Transcription; expressed sequence tags; Complementarity; Signal transduction DO - http://dx.doi.org/10.1093/nar/gkn470 ER - TY - JOUR T1 - Review and special article: Childhood Obesity Prevention and Treatment Recommendations for Future Research AN - 19656980; 8791640 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Pratt, Charlotte A AU - Stevens, June AU - Daniels, Stephen AD - Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, prattc@nhlbi.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 249 EP - 252 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 35 IS - 3 SN - 0749-3797, 0749-3797 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Obesity KW - Preventive health KW - obesity KW - Children KW - Reviews KW - prevention KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19656980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Review+and+special+article%3A+Childhood+Obesity+Prevention+and+Treatment+Recommendations+for+Future+Research&rft.au=Pratt%2C+Charlotte+A%3BStevens%2C+June%3BDaniels%2C+Stephen&rft.aulast=Pratt&rft.aufirst=Charlotte&rft.date=2008-09-01&rft.volume=35&rft.issue=3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.05.025 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Preventive health; Reviews; prevention; obesity; Children DO - http://dx.doi.org/10.1016/j.amepre.2008.05.025 ER - TY - JOUR T1 - Galactose Residues on the Lipooligosaccharide of Moraxella catarrhalis 26404 Form the Epitope Recognized by the Bactericidal Antiserum from Conjugate Vaccination AN - 19645382; 8406439 AB - Lipooligosaccharide (LOS) from Moraxella catarrhalis has the potential to elicit bactericidal antibodies against the pathogen. We generated LOS-based conjugate vaccines that elicited bactericidal antibodies in animal models. However, epitopes on the LOS recognized by the functional anti-LOS antibodies remain unidentified. In this study, a mutant strain, D4, which lost the recognition by a bactericidal anti-LOS rabbit serum in Western blotting was generated from a serotype C strain 26404 by random transposon mutagenesis. Sequence analysis revealed there was an insertion of a kanamycin resistance gene in the lgt2 gene of D4, which encodes b(1-4)-galactosyltransferase. An isogenic lgt2 mutant, 26404lgt2, was constructed. Structural analysis indicated that the mutant strain produced a truncated LOS lacking terminal galactoses from 4- and 6-linked oligosaccharide chains of strain 26404. Further studies showed that the antiserum lost the recognition of both mutant cells and LOSs in Western blotting, an enzyme-linked immunosorbent assay (ELISA), or a flow cytometry assay. The antiserum also lost the ability to kill the mutant strain in a bactericidal assay, whereas it showed a bactericidal titer of 1:80 to strain 26404. In an inhibition ELISA, D-(+)-galactose or 26404lgt2 LOS showed no inhibition. However, the 26404 LOS and a serotype A O35E LOS with terminal galactoses on its 6-linked oligosaccharide chain showed >90% inhibition, while a serotype B 26397 LOS showed >60% inhibition. These studies suggest that the terminal a-Gal-(114)-b-Gal on the 6-linked oligosaccharide chain of 26404 LOS plays a critical role in forming the epitope recognized by the bactericidal antiserum induced by immunization with our conjugate vaccine. JF - Infection and Immunity AU - Yu, Shengqing AU - Xie, Hang AU - Datta, Anup AU - Naidu, Natasha AU - Gu, Xin-Xing AD - Vaccine Research Facility, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850. Glycotechnology Core Resource, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093 Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 4251 EP - 4258 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 9 SN - 0019-9567, 0019-9567 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Galactose KW - Bacteria KW - Western blotting KW - Enzyme-linked immunosorbent assay KW - oligosaccharides KW - Serotypes KW - Moraxella catarrhalis KW - Animal models KW - Kanamycin KW - Pathogens KW - Immunization KW - Lipooligosaccharides KW - Flow cytometry KW - Antibodies KW - transposon mutagenesis KW - Vaccines KW - Epitopes KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19645382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Galactose+Residues+on+the+Lipooligosaccharide+of+Moraxella+catarrhalis+26404+Form+the+Epitope+Recognized+by+the+Bactericidal+Antiserum+from+Conjugate+Vaccination&rft.au=Yu%2C+Shengqing%3BXie%2C+Hang%3BDatta%2C+Anup%3BNaidu%2C+Natasha%3BGu%2C+Xin-Xing&rft.aulast=Yu&rft.aufirst=Shengqing&rft.date=2008-09-01&rft.volume=76&rft.issue=9&rft.spage=4251&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Galactose; Western blotting; Enzyme-linked immunosorbent assay; Serotypes; oligosaccharides; Animal models; Kanamycin; Pathogens; Immunization; Lipooligosaccharides; Flow cytometry; Antibodies; transposon mutagenesis; Vaccines; Epitopes; Bacteria; Moraxella catarrhalis ER - TY - JOUR T1 - Organizational Work Factors among Workers and Supervisors in Export Processing Zones which Support Global Markets AN - 19620231; 8689756 AB - This is an investigation of the interaction between organizational and management factors at work for both workers and supervisors in the manufacturing sector. Survey was done in a sample consisted of 23 establishments, 630 workers, and 47 supervisors, meanwhile 10 focus group discussions (FGDs) for workers, and 5 FGDs for supervisors. Workers and supervisors alike reported illnesses and job dissatisfaction. Survey showed that the most prevalent issues among workers were: the need to upgrade skills (76.3%), pressured in doing work (60.5%), fast paced work (60.5%), repetitive work (63%), and that work is both physically and mentally tiring (59.7%). On the other hand, supervisors described their work as challenging and stimulating (66%), needed regular upgrading of skills (46.8%), and needed literacy on information technology (31.9%). Focus group discussions showed that workers and supervisors were confronted with stress, fast-paced work, the need to upgrade skills due to accommodation of information technology into the work production, fatigue, re-engineering and downsizing by management, low job control and difficult worker-supervisor relationship. This study was able to show that health of workers and supervisors were affected by both organizational and management factors at work. JF - Industrial Health AU - Del Prado-Lu, JL AD - National Institutes of Health, University of the Philippines, Manila, P. Gil Street, Ermita, Manila, Philippines Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 435 EP - 442 VL - 46 IS - 5 SN - 0019-8366, 0019-8366 KW - Health & Safety Science Abstracts KW - Manufacturing industry KW - exports KW - Stress KW - fatigue KW - overuse injuries KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19620231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Organizational+Work+Factors+among+Workers+and+Supervisors+in+Export+Processing+Zones+which+Support+Global+Markets&rft.au=Del+Prado-Lu%2C+JL&rft.aulast=Del+Prado-Lu&rft.aufirst=JL&rft.date=2008-09-01&rft.volume=46&rft.issue=5&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Technology; exports; Stress; overuse injuries; fatigue; Manufacturing industry ER - TY - JOUR T1 - Modification of the Risk of Mortality from Pneumonia with Oral Hygiene Care AN - 19604627; 8531736 AB - OBJECTIVESTo investigate the associations between the assignment of an oral hygiene aide staff member and risk factors for mortality from pneumonia in a nursing home and to test the hypothesis that this care would affect the incidence of mortality from pneumonia. DESIGNElectronic medical records. SETTINGNursing home. PARTICIPANTSOne hundred forty-three residents of a Veterans Affairs Medical Center (VAMC) nursing home. METHODSThe electronic medical records of 143 residents of a VAMC nursing home were analyzed for risk factors for pneumonia. A certified nursing assistant had been assigned to provide oral hygiene care for residents on two of four nursing home wards. Researchers performed a longitudinal analysis of resident's medical records to investigate the association between the assignment of an oral hygiene aide with the risk of mortality from pneumonia. RESULTSInitially, the group that received oral care, an older and less functionally able group, showed approximately the same incidence of mortality from pneumonia as the group that did not receive oral care, but when the data were adjusted for the risk factors found to be significant for mortality from pneumonia, the odds of dying from pneumonia in the group that did not receive oral care was more than three times that of the group that did receive oral care (odds ratio=3.57, P=.03). Modified risk factors included age, functionality, cognitive function, and clinical concern about aspiration pneumonia. CONCLUSIONOral hygiene nursing aide intervention may be an efficient risk factor modifier of mortality from nursing home-associated pneumonia. JF - Journal of the American Geriatrics Society AU - Bassim, Carol W AU - Gibson, Gretchen AU - Ward, Timothy AU - Paphides, Brian M AU - DeNucci, Donald J AD - Dental Service, Washington, DC, Veterans Affairs Medical Center, Washington, District of Columbia, bassimc@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1601 EP - 1607 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 56 IS - 9 SN - 0002-8614, 0002-8614 KW - pneumonia KW - Risk Abstracts KW - Mortality KW - Age KW - cognitive ability KW - intervention KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19604627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Modification+of+the+Risk+of+Mortality+from+Pneumonia+with+Oral+Hygiene+Care&rft.au=Bassim%2C+Carol+W%3BGibson%2C+Gretchen%3BWard%2C+Timothy%3BPaphides%2C+Brian+M%3BDeNucci%2C+Donald+J&rft.aulast=Bassim&rft.aufirst=Carol&rft.date=2008-09-01&rft.volume=56&rft.issue=9&rft.spage=1601&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2008.01825.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mortality; intervention; cognitive ability; Age DO - http://dx.doi.org/10.1111/j.1532-5415.2008.01825.x ER - TY - JOUR T1 - Structure of RapA, a Swi2/Snf2 Protein that Recycles RNA Polymerase During Transcription AN - 19570082; 8837924 AB - RapA, as abundant as [sigma] super(70) in the cell, is an RNA polymerase (RNAP)-associated Swi2/Snf2 protein with ATPase activity. It stimulates RNAP recycling during transcription. We report a structure of RapA that is also a full-length structure for the entire Swi2/Snf2 family. RapA contains seven domains, two of which exhibit novel protein folds. Our model of RapA in complex with ATP and double-stranded DNA (dsDNA) suggests that RapA may bind to and translocate on dsDNA. Our kinetic template-switching assay shows that RapA facilitates the release of sequestered RNAP from a posttranscrption/posttermination complex for transcription reinitiation. Our in vitro competition experiment indicates that RapA binds to core RNAP only but is readily displaceable by [sigma] super(70). RapA is likely another general transcription factor, the structure of which provides a framework for future studies of this bacterial Swi2/Snf2 protein and its important roles in RNAP recycling during transcription. JF - Structure AU - Shaw, Gary AU - Gan, Jianhua AU - Zhou, Yan Ning AU - Zhi, Huijun AU - Subburaman, Priadarsini AU - Zhang, Rongguang AU - Joachimiak, Andrzej AU - Jin, Ding Jun AU - Ji, Xinhua AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA, djjin@helix.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1417 EP - 1427 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 16 IS - 9 SN - 0969-2126, 0969-2126 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - RNA KW - PROTEINS KW - DNA-directed RNA polymerase KW - Adenosinetriphosphatase KW - Kinetics KW - Transcription factors KW - ATP KW - Recycling KW - Competition KW - Snf2 protein KW - J 02330:Biochemistry KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19570082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure&rft.atitle=Structure+of+RapA%2C+a+Swi2%2FSnf2+Protein+that+Recycles+RNA+Polymerase+During+Transcription&rft.au=Shaw%2C+Gary%3BGan%2C+Jianhua%3BZhou%2C+Yan+Ning%3BZhi%2C+Huijun%3BSubburaman%2C+Priadarsini%3BZhang%2C+Rongguang%3BJoachimiak%2C+Andrzej%3BJin%2C+Ding+Jun%3BJi%2C+Xinhua&rft.aulast=Shaw&rft.aufirst=Gary&rft.date=2008-09-01&rft.volume=16&rft.issue=9&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Structure&rft.issn=09692126&rft_id=info:doi/10.1016%2Fj.str.2008.06.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - DNA-directed RNA polymerase; Adenosinetriphosphatase; Transcription factors; Kinetics; ATP; Recycling; Competition; Snf2 protein DO - http://dx.doi.org/10.1016/j.str.2008.06.012 ER - TY - JOUR T1 - Treatment of classic Kaposi sarcoma with a nicotine dermal patch: a phase II clinical trial AN - 19554026; 8484579 AB - BackgroundKaposi sarcoma (KS), a malignancy of dermal endothelial cells that is caused by human herpesvirus 8 (HHV8) infection, is sensitive to perturbations of immunity. Nicotine might be effective against KS because of its immunologic and vascular effects and because smoking is associated with a low risk of KS. Objective and study designWe conducted a masked, randomized phase 2 clinical trial of transdermal nicotine and placebo patches to assess the safety and efficacy of nicotine against classic KS (cKS). Subjects and methodsThree cKS lesions, predominantly nodules, in each of 24 non-smoking patients were randomly assigned to 15weeks continuous treatment with nicotine patch (escalated to 7mg), identical masked placebo patch or no patch. Changes in lesion area and elevation from baseline through six follow-up visits, by direct measurement and by two independent readers using digital photographs of the lesions, were compared using non-parametric and regression methods. Changes in longitudinal levels of HHV8 antibodies and DNA in blood cells were similarly assessed. ResultsThere were no systemic or serious adverse events, and compliance was good. One patient resumed smoking and discontinued patches, and two patients withdrew at week 12 for unrelated indications. Six (29%) of the remaining 21 suspended use of patches to relieve local skin irritation; four of these six completed the trial at reduced dose. Treatment assignment was not associated with significant or consistent changes in cKS lesion area or elevation, HHV8 viral load or antibodies. ConclusionTransdermal nicotine and placebo patches caused no serious toxicities but had no demonstrable effect on nodular cKS lesions or HHV8 levels. JF - Journal of the European Academy of Dermatology and Venereology AU - Goedert, J J AU - Scoppio, B M AU - Pfeiffer, R AU - Neve, L AU - Federici, AB AU - Long, L R AU - Dolan, B M AU - Brambati, M AU - Bellinvia, M AU - Lauria, C AU - Preiss, L AU - Boneschi, V AU - Whitby, D AU - Brambilla, L AD - Viral Epidemiology Branch and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA, goedertj@mail.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1101 EP - 1109 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 22 IS - 9 SN - 0926-9959, 0926-9959 KW - Toxicology Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - drug delivery systems KW - Kaposi sarcoma KW - smoking KW - Skin KW - Human herpesvirus 8 KW - Toxicity KW - Immunity KW - Infection KW - Clinical trials KW - Nodules KW - Irritation KW - Endothelial cells KW - Smoking KW - Malignancy KW - Antibodies KW - Nicotine KW - Risk factors KW - Sarcoma KW - DNA KW - Blood cells KW - Vascular system KW - X 24380:Social Poisons & Drug Abuse KW - F 06910:Microorganisms & Parasites KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19554026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+European+Academy+of+Dermatology+and+Venereology&rft.atitle=Treatment+of+classic+Kaposi+sarcoma+with+a+nicotine+dermal+patch%3A+a+phase+II+clinical+trial&rft.au=Goedert%2C+J+J%3BScoppio%2C+B+M%3BPfeiffer%2C+R%3BNeve%2C+L%3BFederici%2C+AB%3BLong%2C+L+R%3BDolan%2C+B+M%3BBrambati%2C+M%3BBellinvia%2C+M%3BLauria%2C+C%3BPreiss%2C+L%3BBoneschi%2C+V%3BWhitby%2C+D%3BBrambilla%2C+L&rft.aulast=Goedert&rft.aufirst=J&rft.date=2008-09-01&rft.volume=22&rft.issue=9&rft.spage=1101&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+European+Academy+of+Dermatology+and+Venereology&rft.issn=09269959&rft_id=info:doi/10.1111%2Fj.1468-3083.2008.02720.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Skin; Immunity; Toxicity; Infection; Clinical trials; Irritation; Nodules; Endothelial cells; Smoking; Antibodies; Malignancy; Nicotine; Risk factors; DNA; Sarcoma; Blood cells; Vascular system; Human herpesvirus 8 DO - http://dx.doi.org/10.1111/j.1468-3083.2008.02720.x ER - TY - JOUR T1 - Hematopoietic stem cells and progenitors of chronic myeloid leukemia express leukemia-associated antigens: implications for the graft-versus-leukemia effect and peptide vaccine-based immunotherapy AN - 19491391; 8572137 AB - The cure of chronic myeloid leukemia (CML) patients following allogeneic stem cell transplantation (SCT) is attributed to graft versus-leukemia (GVL) effects targeting alloantigens and/or leukemia-associated antigens (LAA) on leukemia cells. To assess the potential of LAA-peptide vaccines in eliminating leukemia in CML patients, we measured WT1, PR3, ELA2 and PRAME expression in CD34+ progenitor subpopulations in CML patients and compared them with minor histocompatibility antigens (mHAgs) HA1 and SMCY. All CD34+ subpopulations expressed similar levels of mHAgs irrespective of disease phase, suggesting that in the SCT setting, mHAgs are the best target for GVL. Furthermore, WT1 was consistently over-expressed in advanced phase (AdP) CML In all CD34+ subpopulations, and mature progenitors of chronic phase (CP) CML compared to healthy individuals. PRAME overexpres sion was limited to more mature AdP-CML progenitors only. Conversely, only CP-CML progenitors had PR3 overexpression, suggesting that PR1-peptide vaccines are only appropriate In CP-CML. Surface expression of WT1 protein in the most primitive hematopoietic stem cells in AdP-CML suggest that they could be targets for WT1 peptide-based vaccines, which in combination with PRAME, could additionally improve targeting differentiated progeny, and benefit patients responding sub optimally to tyrosine kinase inhibitors, or enhance GVL effects in SCT patients. JF - Leukemia AU - Yong, ASM AU - Keyvanfar, K AU - Eniafe, R AU - Savani, B N AU - Rezvani, K AU - Sloand, E M AU - Goldman, J M AU - Barrett, A J AD - Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Building 10-CRC, Rm 3-5140, 10 Center Drive, MSC 1202, Bethesda, MD 20892-1202, USA, yonga@nhlbi.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 1721 EP - 1727 VL - 22 IS - 9 SN - 0887-6924, 0887-6924 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Chronic myeloid leukemia KW - stem cell transplantation KW - Graft-versus-leukemia reaction KW - Immunotherapy KW - CD34 antigen KW - Minor histocompatibility antigens KW - Stem cells KW - Alloantigens KW - Protein-tyrosine kinase KW - Hemopoiesis KW - Progeny KW - Antigen (leukemia-associated) KW - Peptides KW - Vaccines KW - WT1 protein KW - W 30940:Products KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19491391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=Hematopoietic+stem+cells+and+progenitors+of+chronic+myeloid+leukemia+express+leukemia-associated+antigens%3A+implications+for+the+graft-versus-leukemia+effect+and+peptide+vaccine-based+immunotherapy&rft.au=Yong%2C+ASM%3BKeyvanfar%2C+K%3BEniafe%2C+R%3BSavani%2C+B+N%3BRezvani%2C+K%3BSloand%2C+E+M%3BGoldman%2C+J+M%3BBarrett%2C+A+J&rft.aulast=Yong&rft.aufirst=ASM&rft.date=2008-09-01&rft.volume=22&rft.issue=9&rft.spage=1721&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=08876924&rft_id=info:doi/10.1038%2Fleu.2008.161 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chronic myeloid leukemia; Immunotherapy; Graft-versus-leukemia reaction; stem cell transplantation; CD34 antigen; Minor histocompatibility antigens; Stem cells; Protein-tyrosine kinase; Alloantigens; Hemopoiesis; Peptides; Antigen (leukemia-associated); Progeny; Vaccines; WT1 protein DO - http://dx.doi.org/10.1038/leu.2008.161 ER - TY - JOUR T1 - In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide AN - 19280676; 8641727 AB - Objectives To evaluate a novel series of quinoxaline 1,4-di-N-oxides for in vitro activity against Mycobacterium tuberculosis and for efficacy in a mouse model of tuberculosis (TB).Methods Ketone and amide derivatives of quinoxaline 1,4-di-N-oxide were evaluated in in vitro and in vivo tests including: (i) activity against M. tuberculosis resistant to currently used antitubercular drugs including multidrug-resistant strains (MDR-TB resistant to isoniazid and rifampicin); (ii) activity against non-replicating persistent (NRP) bacteria; (iii) MBC; (iv) maximum tolerated dose, oral bioavailability and in vivo efficacy in mice; and (v) potential for cross-resistance with another bioreduced drug, PA-824.Results Ten compounds were tested on single drug-resistant M. tuberculosis. In general, all compounds were active with ratios of MICs against resistant and non-resistant strains of [lE]4.00. One compound, 5, was orally active in a murine model of TB, bactericidal, active against NRP bacteria and active on MDR-TB and poly drug-resistant clinical isolates (resistant to 3-5 antitubercular drugs).Conclusions Quinoxaline 1,4-di-N-oxides represent a new class of orally active antitubercular drugs. They are likely bioreduced to an active metabolite, but the pathway of bacterial activation was different from PA-824, a bioreducible nitroimidazole in clinical trials. Compound 5 was bactericidal and active on NRP organisms indicating that activation occurred in both growing and non-replicating bacteria leading to cell death. The presence of NRP bacteria is believed to be a major factor responsible for the prolonged nature of antitubercular therapy. If the bactericidal activity and activity on non-replicating bacteria in vitro translate to in vivo conditions, quinoxaline 1,4-di-N-oxides may offer a path to shortened therapy. JF - Journal of Antimicrobial Chemotherapy AU - Villar, Raquel AU - Vicente, Esther AU - Solano, Beatriz AU - PErez-Silanes, Silvia AU - Aldana, Ignacio AU - Maddry, Joseph A AU - Lenaerts, Anne J AU - Franzblau, Scott G AU - Cho, Sang-Hyun AU - Monge, Antonio AU - Goldman, Robert C AD - 1 Unidad en InvestigaciOn y Desarrollo de Medicamentos, Centro de InvestigaciOn en FarmacobiologIa Aplicada (CIFA) , Universidad de Navarra , C/Irunlarrea s/n, 31080 Pamplona , Spain, rgoldman@niaid.nih.gov Y1 - 2008/09// PY - 2008 DA - Sep 2008 SP - 547 EP - 554 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 62 IS - 3 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - antitubercular drugs KW - resistance KW - in vivo efficacy KW - Clinical isolates KW - Drug resistance KW - Animal models KW - Metabolites KW - Clinical trials KW - Minimum inhibitory concentration KW - Rifampin KW - Cell death KW - quinoxaline KW - Tuberculosis KW - Nitroimidazole KW - Cross-resistance KW - amides KW - Drugs KW - Bactericidal activity KW - Mycobacterium tuberculosis KW - Isoniazid KW - ketones KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19280676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=In+vitro+and+in+vivo+antimycobacterial+activities+of+ketone+and+amide+derivatives+of+quinoxaline+1%2C4-di-N-oxide&rft.au=Villar%2C+Raquel%3BVicente%2C+Esther%3BSolano%2C+Beatriz%3BPErez-Silanes%2C+Silvia%3BAldana%2C+Ignacio%3BMaddry%2C+Joseph+A%3BLenaerts%2C+Anne+J%3BFranzblau%2C+Scott+G%3BCho%2C+Sang-Hyun%3BMonge%2C+Antonio%3BGoldman%2C+Robert+C&rft.aulast=Villar&rft.aufirst=Raquel&rft.date=2008-09-01&rft.volume=62&rft.issue=3&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkn214 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Drug resistance; Animal models; Metabolites; Minimum inhibitory concentration; Clinical trials; Rifampin; Cell death; quinoxaline; Nitroimidazole; Tuberculosis; Bactericidal activity; Drugs; amides; Cross-resistance; ketones; Isoniazid; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1093/jac/dkn214 ER - TY - CPAPER T1 - 3D-Pharmacophore Based Virtual Screening: Discovery of Opioid GPCR Lead Compounds T2 - 30th European Peptide Symposium (EPS 30) AN - 41093794; 4941455 JF - 30th European Peptide Symposium (EPS 30) AU - Bryant, Sharon AU - Balboni, Gianfranco AU - Guerrini, Remo AU - Salvadori, Severo AU - Marczak, Ewa AU - Lazarus, L H Y1 - 2008/08/31/ PY - 2008 DA - 2008 Aug 31 KW - Lead compounds KW - G protein-coupled receptors KW - Opioids KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41093794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+European+Peptide+Symposium+%28EPS+30%29&rft.atitle=3D-Pharmacophore+Based+Virtual+Screening%3A+Discovery+of+Opioid+GPCR+Lead+Compounds&rft.au=Bryant%2C+Sharon%3BBalboni%2C+Gianfranco%3BGuerrini%2C+Remo%3BSalvadori%2C+Severo%3BMarczak%2C+Ewa%3BLazarus%2C+L+H&rft.aulast=Bryant&rft.aufirst=Sharon&rft.date=2008-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+European+Peptide+Symposium+%28EPS+30%29&rft.issn=&rft_id=info:doi/ L2 - http://www.30eps.fi/programmeoutline.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Can low-dose radiation increase risk of cardiovascular disease? AN - 69486903; 18761208 JF - Lancet (London, England) AU - Bhatti, Parveen AU - Sigurdson, Alice J AU - Mabuchi, Kiyohiko AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/08/30/ PY - 2008 DA - 2008 Aug 30 SP - 697 EP - 699 VL - 372 IS - 9640 KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Cardiovascular Diseases -- etiology KW - Neoplasms -- radiotherapy KW - Dose-Response Relationship, Radiation KW - Environmental Exposure -- adverse effects KW - Radiation Injuries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69486903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Can+low-dose+radiation+increase+risk+of+cardiovascular+disease%3F&rft.au=Bhatti%2C+Parveen%3BSigurdson%2C+Alice+J%3BMabuchi%2C+Kiyohiko&rft.aulast=Bhatti&rft.aufirst=Parveen&rft.date=2008-08-30&rft.volume=372&rft.issue=9640&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/10.1016%2FS0140-6736%2808%2961285-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-09 N1 - Date created - 2008-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0140-6736(08)61285-4 ER - TY - JOUR T1 - Ring expanded nucleoside analogues inhibit RNA helicase and intracellular human immunodeficiency virus type 1 replication. AN - 69465386; 18680273 AB - A series of ring expanded nucleoside (REN) analogues were synthesized and screened for inhibition of cellular RNA helicase activity and human immunodeficiency virus type 1 (HIV-1) replication. We identified two compounds, 1 and 2, that inhibited the ATP dependent activity of human RNA helicase DDX3. Compounds 1 and 2 also suppressed HIV-1 replication in T cells and monocyte-derived macrophages. Neither compound at therapeutic doses was significantly toxic in ex vivo cell culture or in vivo in mice. Our findings provide proof-of-concept that a cellular factor, an RNA helicase, could be targeted for inhibiting HIV-1 replication. JF - Journal of medicinal chemistry AU - Yedavalli, Venkat S R K AU - Zhang, Ning AU - Cai, Hongyi AU - Zhang, Peng AU - Starost, Matthew F AU - Hosmane, Ramachandra S AU - Jeang, Kuan-Teh AD - Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/08/28/ PY - 2008 DA - 2008 Aug 28 SP - 5043 EP - 5051 VL - 51 IS - 16 KW - Azepines KW - 0 KW - Enzyme Inhibitors KW - Nucleosides KW - DDX3X protein, human KW - EC 3.6.1.- KW - DEAD-box RNA Helicases KW - EC 3.6.4.13 KW - Index Medicus KW - Animals KW - Stereoisomerism KW - Humans KW - Mice KW - Cell Line KW - Azepines -- pharmacology KW - DEAD-box RNA Helicases -- antagonists & inhibitors KW - Virus Replication -- drug effects KW - Nucleosides -- pharmacology KW - Nucleosides -- chemical synthesis KW - Enzyme Inhibitors -- pharmacology KW - Enzyme Inhibitors -- chemical synthesis KW - HIV-1 -- physiology KW - HIV-1 -- drug effects KW - Azepines -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69465386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Ring+expanded+nucleoside+analogues+inhibit+RNA+helicase+and+intracellular+human+immunodeficiency+virus+type+1+replication.&rft.au=Yedavalli%2C+Venkat+S+R+K%3BZhang%2C+Ning%3BCai%2C+Hongyi%3BZhang%2C+Peng%3BStarost%2C+Matthew+F%3BHosmane%2C+Ramachandra+S%3BJeang%2C+Kuan-Teh&rft.aulast=Yedavalli&rft.aufirst=Venkat+S+R&rft.date=2008-08-28&rft.volume=51&rft.issue=16&rft.spage=5043&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm800332m LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-10 N1 - Date created - 2008-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Adv Protein Chem. 2001;56:13-75 [11329852] Mol Biotechnol. 2008 Jul;39(3):231-8 [18259889] Prog Nucleic Acid Res Mol Biol. 2001;70:77-118 [11642367] Curr Biol. 2001 Nov 27;11(23):R961-3 [11728322] Nat Med. 2002 Apr;8(4):386-91 [11927945] Nat Med. 2002 Apr;8(4):392-8 [11927946] Cell. 2002 Jun 28;109(7):797-800 [12110176] Infect Immun. 2002 Dec;70(12):7136-9 [12438396] Eur J Biochem. 2003 Apr;270(8):1645-53 [12694177] AIDS Patient Care STDS. 2003 Apr;17(4):169-77 [12737640] J Med Chem. 2003 Sep 11;46(19):4149-64 [12954067] J Med Chem. 2003 Oct 23;46(22):4776-89 [14561097] J Neurosci Res. 2003 Nov 1;74(3):393-405 [14598316] J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):413-21 [14623539] J Gen Virol. 2003 Dec;84(Pt 12):3215-25 [14645903] Nat Rev Mol Cell Biol. 2004 Mar;5(3):232-41 [14991003] Cell. 2004 Oct 29;119(3):381-92 [15507209] J Virol. 1988 Jan;62(1):139-47 [3257102] Nature. 1989 Jan 12;337(6203):121-2 [2563148] Genes Dev. 1997 Oct 15;11(20):2622-32 [9334325] Cell. 1998 Feb 20;92(4):451-62 [9491887] Crit Rev Biochem Mol Biol. 1998;33(4):259-96 [9747670] Nat Med. 1999 Oct;5(10):1110-3 [10502801] J Biol Chem. 2004 Nov 19;279(47):49055-63 [15371436] J Virol. 2005 Jan;79(1):124-31 [15596808] Retrovirology. 2005;2:20 [15780141] Nat Rev Drug Discov. 2005 Oct;4(10):845-53 [16184083] Retrovirology. 2006;3:48 [16893449] Nucleic Acids Res. 2006;34(15):4198-205 [16935887] Retrovirology. 2006;3:69 [17034647] Retrovirology. 2006;3:92 [17169163] Retrovirology. 2007;4:78 [17961213] Adv Pharmacol. 2008;56:327-68 [18086417] Science. 2008 Feb 15;319(5865):921-6 [18187620] Mol Cell. 2001 Aug;8(2):251-62 [11545728] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800332m ER - TY - JOUR T1 - A Randomized, Controlled Trial of Magnesium Sulfate for the Prevention of Cerebral Palsy AN - 223916933; 18753646 AB - Background Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy. Methods In this multicenter, placebo-controlled, double-blind trial, we randomly assigned women at imminent risk for delivery between 24 and 31 weeks of gestation to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour, or matching placebo. The primary outcome was the composite of stillbirth or infant death by 1 year of corrected age or moderate or severe cerebral palsy at or beyond 2 years of corrected age. Results A total of 2241 women underwent randomization. The baseline characteristics were similar in the two groups. Follow-up was achieved for 95.6% of the children. The rate of the primary outcome was not significantly different in the magnesium sulfate group and the placebo group (11.3% and 11.7%, respectively; relative risk, 0.97; 95% confidence interval [CI], 0.77 to 1.23). However, in a prespecified secondary analysis, moderate or severe cerebral palsy occurred significantly less frequently in the magnesium sulfate group (1.9% vs. 3.5%; relative risk, 0.55; 95% CI, 0.32 to 0.95). The risk of death did not differ significantly between the groups (9.5% vs. 8.5%; relative risk, 1.12; 95% CI, 0.85 to 1.47). No woman had a life-threatening event. Conclusions Fetal exposure to magnesium sulfate before anticipated early preterm delivery did not reduce the combined risk of moderate or severe cerebral palsy or death, although the rate of cerebral palsy was reduced among survivors. (ClinicalTrials.gov number, NCT00014989 .) JF - The New England Journal of Medicine AU - Rouse, Dwight J, MD AU - Hirtz, Deborah G, MD AU - Thom, Elizabeth, PhD AU - Varner, Michael W, MD AU - Spong, Catherine Y, MD AU - Mercer, Brian M, MD AU - Iams, Jay D, MD AU - Wapner, Ronald J, MD AU - Sorokin, Yoram, MD AU - Alexander, James M, MD AU - Harper, Margaret, MD AU - Thorp, John M, Jr, MD AU - Ramin, Susan M, MD AU - Malone, Fergal D, MD AU - Carpenter, Marshall, MD AU - Miodovnik, Menachem, MD AU - Moawad, Atef, MD AU - O'Sullivan, Mary J, MD AU - Peaceman, Alan M, MD AU - Hankins, Gary DV, MD AU - Langer, Oded, MD AU - Caritis, Steve N, MD AU - Roberts, James M, MD Y1 - 2008/08/28/ PY - 2008 DA - 2008 Aug 28 SP - 895 EP - 905 CY - Boston PB - Massachusetts Medical Society VL - 359 IS - 9 SN - 00284793 KW - Medical Sciences KW - Tocolytic Agents KW - Magnesium Sulfate KW - Pregnancy KW - Cerebral palsy KW - Drug dosages KW - Confidence intervals KW - Shriver, Eunice Kennedy KW - Magnesium Sulfate -- adverse effects KW - Double-Blind Method KW - Humans KW - Gestational Age KW - Infant, Newborn KW - Infant Mortality KW - Infant, Premature KW - Obstetric Labor, Premature -- drug therapy KW - Adult KW - Tocolytic Agents -- adverse effects KW - Follow-Up Studies KW - Female KW - Cerebral Palsy -- prevention & control KW - Tocolytic Agents -- therapeutic use KW - Magnesium Sulfate -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223916933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=A+Randomized%2C+Controlled+Trial+of+Magnesium+Sulfate+for+the+Prevention+of+Cerebral+Palsy&rft.au=Rouse%2C+Dwight+J%2C+MD%3BHirtz%2C+Deborah+G%2C+MD%3BThom%2C+Elizabeth%2C+PhD%3BVarner%2C+Michael+W%2C+MD%3BSpong%2C+Catherine+Y%2C+MD%3BMercer%2C+Brian+M%2C+MD%3BIams%2C+Jay+D%2C+MD%3BWapner%2C+Ronald+J%2C+MD%3BSorokin%2C+Yoram%2C+MD%3BAlexander%2C+James+M%2C+MD%3BHarper%2C+Margaret%2C+MD%3BThorp%2C+John+M%2C+Jr%2C+MD%3BRamin%2C+Susan+M%2C+MD%3BMalone%2C+Fergal+D%2C+MD%3BCarpenter%2C+Marshall%2C+MD%3BMiodovnik%2C+Menachem%2C+MD%3BMoawad%2C+Atef%2C+MD%3BO%27Sullivan%2C+Mary+J%2C+MD%3BPeaceman%2C+Alan+M%2C+MD%3BHankins%2C+Gary+DV%2C+MD%3BLanger%2C+Oded%2C+MD%3BCaritis%2C+Steve+N%2C+MD%3BRoberts%2C+James+M%2C+MD&rft.aulast=Rouse&rft.aufirst=Dwight&rft.date=2008-08-28&rft.volume=359&rft.issue=9&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=The+New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/10.1056%2FNEJMoa0801187 LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2008 Massachusetts Medical Society. All rights reserved. N1 - People - Shriver, Eunice Kennedy N1 - Last updated - 2014-09-25 N1 - CODEN - NEJMAG N1 - SubjectsTermNotLitGenreText - Shriver, Eunice Kennedy DO - http://dx.doi.org/10.1056/NEJMoa0801187 ER - TY - JOUR T1 - Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. AN - 69471751; 18719106 AB - Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass pathways such as postreplication repair (PRR) to resolve these arrested forks. In yeast, one branch of PRR involves proliferating cell nuclear antigen (PCNA) polyubiquitination mediated by the Rad5-Ubc13-Mms2 complex that allows bypass of DNA lesion by a template-switching mechanism. Previously, we identified human SHPRH as a functional homologue of yeast Rad5 and revealed the existence of RAD5-like pathway in human cells. Here we report the identification of HLTF as a second RAD5 homologue in human cells. HLTF, like SHPRH, shares a unique domain architecture with Rad5 and promotes lysine 63-linked polyubiquitination of PCNA. Similar to yeast Rad5, HLTF is able to interact with UBC13 and PCNA, as well as SHPRH; and the reduction of either SHPRH or HLTF expression enhances spontaneous mutagenesis. Moreover, Hltf-deficient mouse embryonic fibroblasts show elevated chromosome breaks and fusions after methyl methane sulfonate treatment. Our results suggest that HLTF and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA polyubiquitination and maintain genomic stability. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Motegi, Akira AU - Liaw, Hung-Jiun AU - Lee, Kyoo-Young AU - Roest, Henk P AU - Maas, Alex AU - Wu, Xiaoli AU - Moinova, Helen AU - Markowitz, Sanford D AU - Ding, Hao AU - Hoeijmakers, Jan H J AU - Myung, Kyungjae AD - Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/08/26/ PY - 2008 DA - 2008 Aug 26 SP - 12411 EP - 12416 VL - 105 IS - 34 KW - DNA-Binding Proteins KW - 0 KW - HLTF protein, human KW - Proliferating Cell Nuclear Antigen KW - Saccharomyces cerevisiae Proteins KW - Transcription Factors KW - Polyubiquitin KW - 120904-94-1 KW - UBE2N protein, human KW - EC 2.3.2.23 KW - Ubiquitin-Conjugating Enzymes KW - SHPRH protein, human KW - EC 2.3.2.27 KW - Ubiquitin-Protein Ligases KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - RAD5 protein, S cerevisiae KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Structural Homology, Protein KW - Ubiquitin-Conjugating Enzymes -- metabolism KW - DNA Damage KW - Humans KW - Ubiquitination KW - Polyubiquitin -- metabolism KW - Genomic Instability KW - DNA Helicases -- metabolism KW - Transcription Factors -- metabolism KW - Ubiquitin-Protein Ligases -- metabolism KW - Proliferating Cell Nuclear Antigen -- metabolism KW - DNA Replication KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69471751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Polyubiquitination+of+proliferating+cell+nuclear+antigen+by+HLTF+and+SHPRH+prevents+genomic+instability+from+stalled+replication+forks.&rft.au=Motegi%2C+Akira%3BLiaw%2C+Hung-Jiun%3BLee%2C+Kyoo-Young%3BRoest%2C+Henk+P%3BMaas%2C+Alex%3BWu%2C+Xiaoli%3BMoinova%2C+Helen%3BMarkowitz%2C+Sanford+D%3BDing%2C+Hao%3BHoeijmakers%2C+Jan+H+J%3BMyung%2C+Kyungjae&rft.aulast=Motegi&rft.aufirst=Akira&rft.date=2008-08-26&rft.volume=105&rft.issue=34&rft.spage=12411&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0805685105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-24 N1 - Date created - 2008-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Biol. 2002 Mar 5;12(5):435-8 [11882297] BMC Mol Biol. 2008;9:24 [18284681] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4459-64 [11917106] Genomics. 2003 Aug;82(2):153-61 [12837266] Nature. 2003 Sep 11;425(6954):188-91 [12968183] Mutat Res. 2003 Nov 27;532(1-2):117-35 [14643433] J Biol Chem. 2004 May 7;279(19):20067-75 [14982920] Mol Cell. 2004 May 21;14(4):491-500 [15149598] Curr Opin Cell Biol. 2004 Apr;16(2):119-26 [15196553] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9039-44 [15184655] Cell Cycle. 2004 Aug;3(8):1011-3 [15280666] Proc Natl Acad Sci U S A. 1998 May 12;95(10):5678-83 [9576943] Mutat Res. 1998 Mar;407(2):135-45 [9637242] Mol Cell Biol. 1999 Mar;19(3):2206-11 [10022907] Nature. 1999 Jun 17;399(6737):700-4 [10385124] Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1110-5 [15650050] DNA Repair (Amst). 2005 Apr 4;4(4):503-10 [15725630] Nature. 2005 Jul 21;436(7049):428-33 [15931174] Chembiochem. 2005 Oct;6(10):1735-43 [16142820] Mol Cell Biol. 2006 Feb;26(4):1424-33 [16449653] Nat Cell Biol. 2006 Apr;8(4):339-47 [16531995] Nucleic Acids Res. 2006;34(10):2887-905 [16738128] Mol Biol Cell. 2006 Jul;17(7):2976-85 [16641370] PLoS Genet. 2006 Jul;2(7):e116 [16789823] Exp Cell Res. 2006 Aug 15;312(14):2673-6 [16854411] Mol Cell Biol. 2006 Nov;26(21):8032-41 [16923963] J Biol Chem. 2006 Oct 27;281(43):32081-8 [16959771] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18107-12 [17108083] J Cell Biol. 2006 Dec 4;175(5):703-8 [17130289] Mol Cell. 2007 Mar 9;25(5):663-75 [17349954] DNA Repair (Amst). 2007 May 1;6(5):676-86 [17254849] Cell. 2007 May 18;129(4):665-79 [17512402] DNA Repair (Amst). 2007 Jul 1;6(7):891-9 [17363342] Mol Cells. 2008 Jun 30;25(4):457-61 [18443409] Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15591-8 [17898175] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4562-7 [11904375] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0805685105 ER - TY - JOUR T1 - An engineered selenocysteine defines a unique class of antibody derivatives AN - 20239049; 10314853 AB - Selenocysteine is cotranslationally inserted into proteins by recoding the stop codon UGA from termination to selenocysteine insertion. The nucleophilic selenol group of selenocysteine endows this rare amino acid with unique chemical reactivity that allows regiospecific covalent conjugation in the presence of the other natural amino acids. Using a mammalian expression system, we generated an IgG1-derived Fc fragment with a C-terminal selenocysteine in yields comparable to conventional monoclonal antibodies and conjugated it to an electrophilic derivative of a peptidomimetic that binds with high affinity and specificity to integrin alpha sub(4) beta sub(1). Through this conjugation, both the biological and chemical components are endowed with pharmacological advantages. We demonstrate that whereas the Fc protein increases the circulatory half-life from minutes to days and mediates transcytosis through binding to the neonatal Fc receptor, the peptidomimetic introduces cross-species binding to cell surface integrin alpha sub(4) beta sub(1) and blocks its interaction with vascular cell adhesion molecule-1. Compared with conventional monoclonal antibodies, our technology benefits economically from combining a generic biological component with a variable chemical component. JF - Proceedings of the National Academy of Sciences, USA AU - Hofer, Thomas AU - Thomas, Joshua D AU - Burke, Terrence R AU - Rader, Christoph AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1203, raderc@mail.nih.gov Y1 - 2008/08/26/ PY - 2008 DA - 2008 Aug 26 SP - 12451 EP - 12456 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 34 SN - 0027-8424, 0027-8424 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - antibody engineering KW - Fc fragment KW - neonatal Fc receptor KW - small synthetic molecules KW - integrin alpha 4 beta 1 KW - Fc KW - Cell surface KW - vascular cell adhesion molecule 1 KW - Stop codon KW - Amino acids KW - double prime Fc receptors KW - Monoclonal antibodies KW - Integrins KW - peptidomimetics KW - Selenocysteine KW - Neonates KW - W 30925:Genetic Engineering KW - F 06955:Immunomodulation & Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=An+engineered+selenocysteine+defines+a+unique+class+of+antibody+derivatives&rft.au=Hofer%2C+Thomas%3BThomas%2C+Joshua+D%3BBurke%2C+Terrence+R%3BRader%2C+Christoph&rft.aulast=Hofer&rft.aufirst=Thomas&rft.date=2008-08-26&rft.volume=105&rft.issue=34&rft.spage=12451&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0800800105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - vascular cell adhesion molecule 1; Cell surface; Fc; Stop codon; Amino acids; double prime Fc receptors; Integrins; Monoclonal antibodies; peptidomimetics; Selenocysteine; Neonates DO - http://dx.doi.org/10.1073/pnas.0800800105 ER - TY - JOUR T1 - The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C. AN - 69440519; 18556656 AB - Finding rapid, reversible down-regulation of human UDP-glucuronosyltransferases (UGTs) in LS180 cells following curcumin treatment led to the discovery that UGTs require phosphorylation. UGTs, distributed primarily in liver, kidney, and gastrointestinal tract, inactivate aromatic-like metabolites and a vast number of dietary and environmental chemicals, which reduces the risk of toxicities, mutagenesis, and carcinogenesis. Our aim here is to determine relevant kinases and mechanism(s) regulating phosphorylation of constitutive UGTs in LS180 cells and 10 different human UGT cDNA-transfected COS-1 systems. Time- and concentration-dependent inhibition of immunodetectable [(33)P]orthophosphate in UGTs and protein kinase Cepsilon (PKCepsilon), following treatment of LS180 cells with curcumin or the PKC inhibitor calphostin-C, suggested UGT phosphorylation is supported by active PKC(s). Immunofluorescent and co-immunoprecipitation studies with UGT-transfected cells showed co-localization of UGT1A7His and PKCepsilon and of UGT1A10His and PKCalpha or PKCdelta. Inhibition of UGT activity by PKCepsilon-specific antagonist peptide or by PKCepsilon-targeted destruction with PKCepsilon-specific small interference RNA and activation of curcumin-down-regulated UGTs with typical PKC agonists verified a central PKC role in glucuronidation. Moreover, in vitro phosphorylation of nascent UGT1A7His by PKCepsilon confirms it is a bona fide PKC substrate. Finally, catalase or herbimycin-A inhibition of constitutive or hydrogen peroxide-activated-UGTs demonstrated that reactive oxygen species-related oxidants act as second messengers in maintaining constitutive PKC-dependent signaling evidently sustaining UGT phosphorylation and activity. Because cells use signal transduction collectively to detect and respond appropriately to environmental changes, this report, combined with our earlier demonstration that specific phospho-groups in UGT1A7 determined substrate selections, suggests regulated phosphorylation allows adaptations regarding differential phosphate utilization by UGTs to function efficiently. JF - The Journal of biological chemistry AU - Basu, Nikhil K AU - Kole, Labanyamoy AU - Basu, Mousumi AU - Chakraborty, Kushal AU - Mitra, Partha S AU - Owens, Ida S AD - Heritable Disorders Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892-1830, USA. Y1 - 2008/08/22/ PY - 2008 DA - 2008 Aug 22 SP - 23048 EP - 23061 VL - 283 IS - 34 SN - 0021-9258, 0021-9258 KW - Antioxidants KW - 0 KW - Hydrogen Peroxide KW - BBX060AN9V KW - bilirubin uridine-diphosphoglucuronosyl transferase 1A10 KW - EC 2.4.1.- KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - UGT1A7 protein, human KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Antioxidants -- metabolism KW - Phosphorylation KW - COS Cells KW - Humans KW - Hydrogen Peroxide -- pharmacology KW - Cercopithecus aethiops KW - Cell Line, Tumor KW - RNA Interference KW - Models, Biological KW - Signal Transduction KW - Protein Kinase C -- metabolism KW - Glucuronosyltransferase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69440519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+major+chemical-detoxifying+system+of+UDP-glucuronosyltransferases+requires+regulated+phosphorylation+supported+by+protein+kinase+C.&rft.au=Basu%2C+Nikhil+K%3BKole%2C+Labanyamoy%3BBasu%2C+Mousumi%3BChakraborty%2C+Kushal%3BMitra%2C+Partha+S%3BOwens%2C+Ida+S&rft.aulast=Basu&rft.aufirst=Nikhil&rft.date=2008-08-22&rft.volume=283&rft.issue=34&rft.spage=23048&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M800032200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-06 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Jul 2;279(27):28320-9 [15117964] Drug Metab Dispos. 2004 Mar;32(3):281-90 [14977861] Science. 1984 Sep 7;225(4666):1032-4 [6474163] J Biol Chem. 1990 May 15;265(14):7900-6 [2159463] J Biol Chem. 1991 Jan 15;266(2):1043-7 [1898728] Biochemistry. 1993 Oct 12;32(40):10648-57 [8399210] J Biol Chem. 1993 Nov 5;268(31):23573-9 [8226884] Cancer Res. 1995 Jan 15;55(2):259-66 [7812955] Science. 1995 Apr 14;268(5208):247-51 [7716516] Science. 1995 Oct 13;270(5234):296-9 [7569979] Biochemistry. 1996 Aug 6;35(31):10119-24 [8756475] J Biol Chem. 1996 Oct 4;271(40):24962-6 [8798776] Circ Res. 1996 Dec;79(6):1086-99 [8943947] Free Radic Biol Med. 1997;22(1-2):269-85 [8958153] J Biol Chem. 1997 Jan 17;272(3):1417-20 [8999804] Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11233-7 [9326592] J Biol Chem. 1997 Nov 14;272(46):29200-6 [9360998] J Biol Chem. 1997 Dec 5;272(49):30945-51 [9388241] Clin Exp Pharmacol Physiol. 1997 Dec;24(12):907-15 [9406655] Pharmacogenetics. 1997 Dec;7(6):485-95 [9429234] J Mol Cell Cardiol. 1998 Jan;30(1):61-73 [9500865] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3483-8 [9520392] Ann N Y Acad Sci. 1998 Jun 30;851:139-46 [9668616] Biochem J. 1998 Aug 15;334 ( Pt 1):243-9 [9693126] Br J Pharmacol. 1998 Jul;124(6):1029-40 [9720770] J Biol Chem. 1998 Nov 6;273(45):29986-94 [9792719] Drug Metab Dispos. 1999 Apr;27(4):486-94 [10101144] Carcinogenesis. 1999 Mar;20(3):445-51 [10190560] Biochem Biophys Res Commun. 1999 Jun 24;260(1):199-202 [10381366] J Biol Chem. 1999 Sep 3;274(36):25821-6 [10464322] FASEB J. 1999 Oct;13(13):1658-76 [10506570] Proc Natl Acad Sci U S A. 2005 May 3;102(18):6285-90 [15845768] Cancer Res. 2006 Oct 1;66(19):9379-84 [17018591] Biochem Biophys Res Commun. 2007 Aug 17;360(1):7-13 [17586469] Biochim Biophys Acta. 1974 Feb 22;333(2):180-6 [19400030] Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12798-803 [10536002] Biochem J. 1999 Dec 1;344 Pt 2:469-75 [10567230] Free Radic Biol Med. 2000 May 1;28(9):1349-61 [10924854] J Immunol. 2000 Sep 1;165(5):2809-17 [10946313] Br J Pharmacol. 2000 Oct;131(4):711-20 [11030720] Oncogene. 2001 Jan 11;20(2):219-30 [11313949] Food Chem Toxicol. 2002 Aug;40(8):1091-7 [12067569] J Biol Chem. 2002 Jun 21;277(25):22131-9 [11940570] J Biol Chem. 2002 Dec 6;277(49):47878-84 [12372837] J Nutr. 2002 Dec;132(12):3819S-3823S [12468631] Biochem Biophys Res Commun. 2003 Mar 28;303(1):98-104 [12646172] Oncogene. 2003 Oct 23;22(48):7677-86 [14576831] J Biol Chem. 2004 Jan 9;279(2):1429-41 [14557274] World Rev Nutr Diet. 1976;24:117-91 [790781] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M800032200 ER - TY - JOUR T1 - Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission. AN - 69439299; 18556653 AB - Topoisomerase I (Top1) is known to relax DNA supercoiling generated by transcription, replication, and chromatin remodeling. However, it can be trapped on DNA as cleavage complexes (Top1cc) by oxidative and carcinogenic DNA lesions, base damage, and camptothecin treatment. We show here that Top1 is also functionally involved in death receptor-induced programmed cell death. In cells exposed to TRAIL or Fas ligand, Top1cc form at the onset of apoptosis. Those apoptotic Top1cc are prevented by caspase inhibition and Bax inactivation, indicating that both caspases and the mitochondrial death pathway are required for their formation. Accordingly, direct activation of the mitochondrial pathway by BH3 mimetic molecules induces apoptotic Top1cc. We also show that TRAIL-induced apoptotic Top1cc are preferentially formed by caspase-3-cleaved Top1 at sites of oxidative DNA lesions with an average of one apoptotic Top1cc/100 kbp. Examination of Top1 knock-down cells treated with TRAIL revealed similar DNA fragmentation but a marked decrease in apoptotic nuclear fission with reduced formation of nuclear bodies. Thus, we propose that Top1 contributes to the full apoptotic responses induced by TRAIL. JF - The Journal of biological chemistry AU - Sordet, Olivier AU - Goldman, Abby AU - Redon, Christophe AU - Solier, Stéphanie AU - Rao, V Ashutosh AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892-4255, USA. Y1 - 2008/08/22/ PY - 2008 DA - 2008 Aug 22 SP - 23200 EP - 23208 VL - 283 IS - 34 SN - 0021-9258, 0021-9258 KW - Receptors, TNF-Related Apoptosis-Inducing Ligand KW - 0 KW - TNF-Related Apoptosis-Inducing Ligand KW - DNA KW - 9007-49-2 KW - Caspases KW - EC 3.4.22.- KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Oxygen KW - S88TT14065 KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Apoptosis KW - Camptothecin -- pharmacology KW - Cell Nucleus -- metabolism KW - Humans KW - Jurkat Cells KW - TNF-Related Apoptosis-Inducing Ligand -- metabolism KW - Cell Line, Tumor KW - Models, Biological KW - Caspases -- metabolism KW - Oxidative Stress KW - DNA -- chemistry KW - Oxygen -- chemistry KW - Receptors, TNF-Related Apoptosis-Inducing Ligand -- metabolism KW - Gene Expression Regulation, Neoplastic KW - DNA Topoisomerases, Type I -- physiology KW - DNA Topoisomerases, Type I -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69439299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Topoisomerase+I+requirement+for+death+receptor-induced+apoptotic+nuclear+fission.&rft.au=Sordet%2C+Olivier%3BGoldman%2C+Abby%3BRedon%2C+Christophe%3BSolier%2C+St%C3%A9phanie%3BRao%2C+V+Ashutosh%3BPommier%2C+Yves&rft.aulast=Sordet&rft.aufirst=Olivier&rft.date=2008-08-22&rft.volume=283&rft.issue=34&rft.spage=23200&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M801146200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-06 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 2003 Jan 6;160(1):65-75 [12515825] Cancer Res. 2007 Sep 15;67(18):8752-61 [17875716] Cancer Res. 2003 Dec 1;63(23):8203-11 [14678976] DNA Repair (Amst). 2004 Apr 1;3(4):387-93 [15010314] J Biol Chem. 2004 Apr 9;279(15):14587-94 [14688260] Cell. 2004 Jun 11;117(6):773-86 [15186778] J Biol Chem. 2004 Aug 6;279(32):33968-75 [15178684] Ann Rheum Dis. 2004 Sep;63(9):1135-44 [15308524] Nature. 1993 Sep 16;365(6443):227-32 [8396729] Oncol Res. 1993;5(12):467-74 [8086668] Cancer Res. 1995 May 15;55(10):2097-103 [7743509] Cancer Res. 1995 May 15;55(10):2116-21 [7743511] J Biol Chem. 1996 Jan 26;271(4):1993-7 [8567649] Nature. 1996 May 2;381(6577):80-2 [8609994] Mol Cell Biol. 1996 Dec;16(12):6804-9 [8943335] Genes Dev. 1997 Feb 1;11(3):397-407 [9030691] J Biol Chem. 1997 Oct 17;272(42):26441-7 [9334220] EMBO J. 1998 Mar 16;17(6):1675-87 [9501089] Cell. 1998 Aug 21;94(4):481-90 [9727491] Science. 1998 Nov 20;282(5393):1497-501 [9822382] Nat Med. 1999 Feb;5(2):157-63 [9930862] J Biol Chem. 1999 Feb 12;274(7):4335-40 [9933635] J Biol Chem. 1999 Mar 26;274(13):8516-23 [10085084] Nucleic Acids Res. 1999 Jun 15;27(12):2538-44 [10352183] Genes Dev. 1999 Jun 15;13(12):1553-60 [10385624] J Clin Invest. 1999 Jul;104(2):155-62 [10411544] J Cell Biol. 1999 Sep 6;146(5):905-16 [10477747] J Biol Chem. 2004 Nov 26;279(48):50499-504 [15448130] Cell Cycle. 2004 Sep;3(9):1095-7 [15326388] Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):482-96 [15706096] Cancer Res. 2005 May 1;65(9):3894-902 [15867389] Chromosoma. 2005 Jul;114(2):75-85 [15830206] Cancer Res. 2005 Aug 15;65(16):7436-45 [16103097] Nat Rev Mol Cell Biol. 2005 Sep;6(9):677-88 [16103871] Prog Nucleic Acid Res Mol Biol. 2006;81:179-229 [16891172] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Cancer Res. 2007 Dec 15;67(24):11848-58 [18089815] Proc Natl Acad Sci U S A. 2008 May 6;105(18):6782-6 [18443285] Nat Genet. 2000 Jun;25(2):177-81 [10835632] Cytokine. 2000 Jul;12(7):881-7 [10880232] Genes Dev. 2000 Aug 15;14(16):2060-71 [10950869] Curr Biol. 2000 Jul 27-Aug 10;10(15):923-6 [10959840] Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10739-44 [10995470] Adv Cancer Res. 2001;80:189-216 [11034544] Science. 2000 Nov 3;290(5493):989-92 [11062132] J Biol Chem. 2000 Dec 29;275(52):41107-13 [11016921] Mol Cancer Ther. 2006 Dec;5(12):3139-44 [17172417] Oncogene. 2007 Jan 4;26(1):123-31 [16799632] Cell Death Differ. 2007 Feb;14(2):358-67 [16841091] Nat Cell Biol. 2001 Feb;3(2):173-82 [11175750] Nat Cell Biol. 2001 Feb;3(2):183-91 [11175751] Cancer Res. 2001 Aug 1;61(15):5926-32 [11479235] Drug Resist Updat. 2001 Apr;4(2):85-91 [11512525] FEBS Lett. 2002 Feb 13;512(1-3):313-8 [11852102] Cancer Res. 2002 Mar 15;62(6):1583-7 [11912124] Nat Rev Mol Cell Biol. 2002 Jun;3(6):430-40 [12042765] Nat Rev Cancer. 2002 Jun;2(6):420-30 [12189384] J Biol Chem. 2002 Oct 18;277(42):40020-6 [12149243] J Struct Biol. 2002 Oct-Dec;140(1-3):232-40 [12490171] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Cancer Res. 2003 Mar 1;63(5):1000-11 [12615715] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M801146200 ER - TY - JOUR T1 - ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3. AN - 69437713; 18579531 AB - Hypoxia induces oxidative damage in skeletal muscle. Uncoupling protein 3 (UCP3) is the skeletal muscle enriched uncoupling protein and has previously been shown to confer resistance against oxidative stress. We show that hypoxia robustly up-regulates skeletal muscle UCP3 and that the absence of UCP3 in primary skeletal myocytes exacerbates hypoxia-induced reactive oxygen species generation. In this context, we reasoned that the investigation of the regulation of UCP3 may identify novel hypoxia-responsive regulatory pathways that modulate intrinsic anti-oxidant defenses. By screening a transcription factor array of 704 full-length cDNAs in murine C2C12 myoblasts following cotransfection of a murine UCP3 promoter-luciferase construct and myoD we identified numerous candidate regulatory factors that up-regulate UCP3. Active transcription factor-1 (ATF-1) was identified, and as this transcription factor is a known component of a multiprotein hypoxia-induced regulatory complex, we explored its role in hypoxia-mediated UCP3 up-regulation. Site-directed mutagenesis and chromatin immunoprecipitation assays identify a 10-bp region required for ATF-1 induction of UCP3 promoter activity. Hypoxia promotes the phosphorylation of ATF-1, and the knockdown of ATF-1 by shRNA prevents hypoxia-mediated up-regulation of UCP3. Pharmacologic inhibition of p38 MAP kinase prevents both hypoxia-mediated ATF-1 phosphorylation and UCP3 up-regulation. PKA signaling does not modulate hypoxia-induced UCP3 up-regulation and neither does HIF-1alpha activation by cobalt chloride. In conclusion, ATF-1, via p38 MAP kinase activation, functions as a novel regulatory pathway driving UCP3 expression. These data reinforce the role of ATF-1 as a hypoxia-responsive trans-activator and identifies a novel regulatory program that may modulate cellular responses to oxygen-deficit. JF - The Journal of biological chemistry AU - Lu, Zhongping AU - Sack, Michael N AD - Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1454, USA. Y1 - 2008/08/22/ PY - 2008 DA - 2008 Aug 22 SP - 23410 EP - 23418 VL - 283 IS - 34 SN - 0021-9258, 0021-9258 KW - Activating Transcription Factor 1 KW - 0 KW - Antioxidants KW - Ion Channels KW - Mitochondrial Proteins KW - RNA, Small Interfering KW - Ucp3 protein, mouse KW - Uncoupling Protein 3 KW - Cobalt KW - 3G0H8C9362 KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - cobaltous chloride KW - EVS87XF13W KW - Index Medicus KW - Animals KW - Antioxidants -- metabolism KW - Transfection KW - Mice KW - Cobalt -- pharmacology KW - RNA, Small Interfering -- metabolism KW - Models, Biological KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Transcriptional Activation KW - Cell Line KW - Activating Transcription Factor 1 -- metabolism KW - Hypoxia KW - Mitochondria -- metabolism KW - Mitochondrial Proteins -- metabolism KW - Muscle, Skeletal -- metabolism KW - Activating Transcription Factor 1 -- physiology KW - Ion Channels -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69437713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=ATF-1+is+a+hypoxia-responsive+transcriptional+activator+of+skeletal+muscle+mitochondrial-uncoupling+protein+3.&rft.au=Lu%2C+Zhongping%3BSack%2C+Michael+N&rft.aulast=Lu&rft.aufirst=Zhongping&rft.date=2008-08-22&rft.volume=283&rft.issue=34&rft.spage=23410&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M801236200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-06 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 May 26;275(21):16258-66 [10748196] J Clin Invest. 2007 Jul;117(7):1995-2003 [17571165] Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E622-9 [10950831] Life Sci. 2000 Sep 22;67(18):2267-79 [11045607] FASEB J. 2000 Nov;14(14):2141-3 [11024001] Cell Signal. 2001 Jan;13(1):23-7 [11257444] Nat Rev Mol Cell Biol. 2001 Aug;2(8):599-609 [11483993] FASEB J. 2001 Sep;15(11):2033-5 [11511517] Oncogene. 2001 Oct 11;20(46):6653-9 [11709699] Nature. 2002 Jan 3;415(6867):96-9 [11780125] Mol Cell Biol. 2002 Mar;22(6):1919-25 [11865068] Ann N Y Acad Sci. 2002 Jun;968:65-74 [12119268] EMBO J. 2003 Aug 15;22(16):4103-10 [12912909] Mol Endocrinol. 2003 Oct;17(10):1944-58 [12843208] J Cell Biol. 1994 Jun;125(6):1275-87 [8207057] J Biol Chem. 1995 Jan 20;270(3):1230-7 [7836384] J Biol Chem. 1995 Apr 28;270(17):10304-13 [7730336] Mol Cell Neurosci. 1995 Apr;6(2):168-83 [7551568] Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10521-5 [7479832] Nucleic Acids Res. 1995 Nov 25;23(22):4542-50 [8524640] Biochem Biophys Res Commun. 1998 May 8;246(1):287-92 [9600108] Mol Cell Biol. 1998 Jul;18(7):4089-96 [9632793] Biochem J. 2005 Mar 15;386(Pt 3):505-13 [15496137] FEBS Lett. 2005 Jun 20;579(16):3411-5 [15922330] Cell Metab. 2005 Aug;2(2):85-93 [16098826] Biochim Biophys Acta. 2005 Sep 5;1709(2):150-6 [16084485] J Appl Physiol (1985). 2005 Oct;99(4):1247-53 [15905323] J Biol Chem. 2005 Sep 30;280(39):33470-6 [16079144] Thorax. 2005 Oct;60(10):834-41 [15964914] Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1304-12 [16434555] Cardiovasc Res. 2006 Jul 15;71(2):280-8 [16483558] Cardiovasc Res. 2006 Nov 1;72(2):210-9 [16914124] FEBS J. 2007 Jul;274(13):3210-7 [17565598] J Biol Chem. 2007 Oct 26;282(43):31257-66 [17761668] J Biochem Mol Biol. 2007 Nov 30;40(6):921-7 [18047787] Biochem J. 2008 Jan 1;409(1):19-26 [18062771] Nat Med. 2007 Dec;13(12):1496-503 [18059282] J Appl Physiol (1985). 2007 Jun;102(6):2379-88 [17289907] Biochem J. 2007 Jul 1;405(1):1-9 [17555402] N Engl J Med. 2007 Jun 14;356(24):2457-71 [17517853] Oncogene. 2000 May 18;19(22):2721-30 [10851072] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M801236200 ER - TY - JOUR T1 - Performing nondiagnostic research biopsies in irradiated tissue: a review of scientific, clinical, and ethical considerations. AN - 69443920; 18711189 AB - Recent development of drugs that target specific pathways in tumors has increased scientific interest in studying drug effects on tumor tissue. As a result, biopsies have become an important part of many early-phase clinical trials. Performing nondiagnostic tumor biopsies raises technical and ethical concerns mostly related to the use of a potentially harmful procedure with no potential benefit to the patient. This issue is complicated by uncertainty about whether performing biopsies in irradiated fields adds significant risk. This article reviews the clinical, scientific, and ethical considerations involved in performing nondiagnostic tumor biopsies in competent adults for research purposes, with a focus on biopsies performed in the setting of therapeutic irradiation. Clinical trials that performed biopsies during or within 4 months of the completion of radiotherapy were identified with a literature review. Twenty-nine studies with 2,160 patients were identified. Sixteen of 29 studies reported adverse events (AEs) but did not report active evaluation for biopsy complications. Ten studies did not mention AEs within the study report. At least three studies actively evaluated patients for biopsy complications. Taking this into consideration, 17 (>1%) of 2,160 patients were reported to have biopsy complications, although reporting of AEs was suboptimal in most studies. Limited data suggest that biopsies can be performed in irradiated tissues without clinically significant excess risk. Ongoing and future trials including nondiagnostic research biopsies should record and report AEs related to this procedure to provide additional data on safety and toxicity. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Brown, Aaron P AU - Wendler, David S AU - Camphausen, Kevin A AU - Miller, Franklin G AU - Citrin, Deborah AD - Radiation Oncology Branch, National Cancer Institute, 10 CRC, B2-3500, Bethesda, MD 20892, USA. Y1 - 2008/08/20/ PY - 2008 DA - 2008 Aug 20 SP - 3987 EP - 3994 VL - 26 IS - 24 KW - Index Medicus KW - Humans KW - Radiotherapy -- adverse effects KW - Biopsy -- ethics KW - Neoplasms -- pathology KW - Neoplasms -- radiotherapy KW - Clinical Trials as Topic -- ethics KW - Biopsy -- methods KW - Clinical Trials as Topic -- methods KW - Biopsy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69443920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Performing+nondiagnostic+research+biopsies+in+irradiated+tissue%3A+a+review+of+scientific%2C+clinical%2C+and+ethical+considerations.&rft.au=Brown%2C+Aaron+P%3BWendler%2C+David+S%3BCamphausen%2C+Kevin+A%3BMiller%2C+Franklin+G%3BCitrin%2C+Deborah&rft.aulast=Brown&rft.aufirst=Aaron&rft.date=2008-08-20&rft.volume=26&rft.issue=24&rft.spage=3987&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.16.9896 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-08-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1996 Sep;14(9):2527-39 [8823332] J Clin Oncol. 1996 Jan;14(1):119-26 [8558186] J Thorac Imaging. 1998 Jan;13(1):2-6 [9440831] Cancer. 1998 Jul 1;83(1):103-10 [9655299] Radiother Oncol. 1998 Jun;47(3):255-61 [9681888] J Reconstr Microsurg. 1998 Jul;14(5):337-40 [9714040] J Clin Oncol. 1998 Nov;16(11):3576-83 [9817278] J Clin Oncol. 1996 Mar;14(3):859-68 [8622034] Strahlenther Onkol. 1999 Mar;175(3):97-101 [10093610] Cancer. 1999 Apr 1;85(7):1446-53 [10193933] Semin Radiat Oncol. 1999 Apr;9(2 Suppl 1):77-84 [10210544] Head Neck. 1999 Oct;21(7):595-601 [10487945] Int J Radiat Oncol Biol Phys. 2004 Dec 1;60(5):1440-50 [15590175] Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1390-8 [16029798] ANZ J Surg. 2005 Aug;75(8):662-4 [16076328] J Clin Oncol. 2006 Feb 1;24(4):650-5 [16446336] Tumori. 2005 Sep-Oct;91(5):406-14 [16459637] J Urol. 2006 May;175(5):1605-12 [16600713] J Med Ethics. 2006 May;32(5):252-5 [16648272] Breast J. 2006 May-Jun;12(3):194-8 [16684314] J Thorac Cardiovasc Surg. 2006 Jun;131(6):1229-35 [16733150] Eur J Radiol. 2006 Jul;59(1):60-4 [16530369] J Clin Oncol. 2006 Jul 1;24(19):2987-90 [16809725] J Clin Oncol. 2006 Oct 20;24(30):4793-5 [17050863] J Clin Oncol. 2006 Oct 20;24(30):4801-7 [17050865] Hernia. 2006 Dec;10(6):502-6 [17047884] J Clin Oncol. 2007 Apr 10;25(11):1454-5 [17416872] Cancer Invest. 2007 Mar;25(2):124-6 [17453824] Cancer Treat Rev. 2007 Aug;33(5):437-47 [17512669] Cancer Biol Ther. 2007 Jun;6(6):905-11 [17582213] PLoS Med. 2007 Nov 27;4(11):e324 [18044980] J Clin Oncol. 1999 Apr;17(4):1155 [10561174] Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):1111-7 [11072170] JAMA. 2000 Dec 6;284(21):2687-8 [11105155] Oncologist. 2000;5(6):471-6 [11110598] J Urol. 2001 Sep;166(3):856-60 [11490233] Arch Otolaryngol Head Neck Surg. 2001 Dec;127(12):1451-6 [11735813] JAMA. 2002 Jan 2;287(1):78-84 [11754712] Int J Radiat Oncol Biol Phys. 2002 Apr 1;52(5):1303-9 [11955743] Radiother Oncol. 2002 May;63(2):129-45 [12063002] J Clin Oncol. 2003 Mar 15;21(6):1119-24 [12637479] J Clin Oncol. 2003 Jul 1;21(13):2589-96 [12829680] Anticancer Res. 2003 Jul-Aug;23(4):3513-6 [12926100] JAMA. 2003 Aug 27;290(8):1075-82 [12941681] World J Surg. 2003 Jul;27(7):875-83 [14509522] Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):665-72 [14529770] Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):555-60 [14751527] Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):197-207 [15093917] Biomed Pharmacother. 2004 Oct;58(8):451-7 [15464875] Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1441-5 [6469767] Radiology. 1991 Jan;178(1):253-8 [1984314] Arch Surg. 1992 Mar;127(3):321-4 [1550480] Int J Radiat Oncol Biol Phys. 1993 Apr 2;25(5):783-90 [8478228] Clin Dermatol. 1994 Jan-Mar;12(1):57-70 [8180946] Int J Colorectal Dis. 1994 Apr;9(1):23-30 [8027619] J Clin Oncol. 1995 May;13(5):1062-72 [7738612] J Clin Oncol. 1997 Mar;15(3):1022-9 [9060542] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2008.16.9896 ER - TY - JOUR T1 - In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. AN - 69430744; 18703742 AB - Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by direct parasitization of macrophages, but the early events following transmission to the skin by vector sand flies have been difficult to examine directly. Using dynamic intravital microscopy and flow cytometry, we observed a rapid and sustained neutrophilic infiltrate at localized sand fly bite sites. Invading neutrophils efficiently captured Leishmania major (L.m.) parasites early after sand fly transmission or needle inoculation, but phagocytosed L.m. remained viable and infected neutrophils efficiently initiated infection. Furthermore, neutrophil depletion reduced, rather than enhanced, the ability of parasites to establish productive infections. Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease. JF - Science (New York, N.Y.) AU - Peters, Nathan C AU - Egen, Jackson G AU - Secundino, Nagila AU - Debrabant, Alain AU - Kimblin, Nicola AU - Kamhawi, Shaden AU - Lawyer, Phillip AU - Fay, Michael P AU - Germain, Ronald N AU - Sacks, David AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 970 EP - 974 VL - 321 IS - 5891 KW - Index Medicus KW - Cell Movement KW - Insect Vectors -- parasitology KW - Skin -- parasitology KW - Animals KW - Apoptosis KW - Insect Bites and Stings KW - Macrophages -- parasitology KW - Mice KW - Mice, Transgenic KW - Skin -- immunology KW - Host-Parasite Interactions KW - Microscopy KW - Mice, Inbred C57BL KW - Flow Cytometry KW - Phagocytosis KW - Leishmania major -- physiology KW - Phlebotomus -- parasitology KW - Neutrophils -- immunology KW - Neutrophils -- parasitology KW - Leishmaniasis, Cutaneous -- immunology KW - Leishmania major -- immunology KW - Neutrophils -- physiology KW - Leishmaniasis, Cutaneous -- transmission KW - Leishmaniasis, Cutaneous -- parasitology KW - Neutrophil Infiltration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69430744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=In+vivo+imaging+reveals+an+essential+role+for+neutrophils+in+leishmaniasis+transmitted+by+sand+flies.&rft.au=Peters%2C+Nathan+C%3BEgen%2C+Jackson+G%3BSecundino%2C+Nagila%3BDebrabant%2C+Alain%3BKimblin%2C+Nicola%3BKamhawi%2C+Shaden%3BLawyer%2C+Phillip%3BFay%2C+Michael+P%3BGermain%2C+Ronald+N%3BSacks%2C+David&rft.aulast=Peters&rft.aufirst=Nathan&rft.date=2008-08-15&rft.volume=321&rft.issue=5891&rft.spage=970&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/10.1126%2Fscience.1159194 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-26 N1 - Date created - 2008-08-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10125-30 [18626016] Int J Parasitol. 2004 Aug;34(9):991-6 [15313126] Immunol Rev. 2007 Oct;219:88-102 [17850484] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6704-9 [10841567] J Immunol. 2000 Jul 15;165(2):969-77 [10878373] Blood. 2000 Jul 15;96(2):719-26 [10887140] J Immunol. 2000 Sep 1;165(5):2628-36 [10946291] Science. 2000 Nov 17;290(5495):1351-4 [11082061] J Infect Dis. 2002 Mar 1;185(5):673-81 [11865425] J Immunol. 2002 Jul 15;169(2):898-905 [12097394] Nature. 2002 Aug 29;418(6901):983-8 [12198548] J Leukoc Biol. 2004 Apr;75(4):612-23 [14726498] Immunology. 2004 Sep;113(1):1-14 [15312130] J Immunol. 2008 Apr 1;180(7):4355-60 [18354154] J Immunol. 2004 Dec 1;173(11):6521-5 [15557140] Annu Rev Immunol. 2005;23:197-223 [15771570] Parasitol Int. 2005 Jun;54(2):109-18 [15866472] Trends Cell Biol. 2005 Nov;15(11):599-607 [16202600] J Immunol. 2005 Dec 15;175(12):8346-53 [16339576] Nat Med. 2006 Feb;12(2):220-4 [16429144] Apoptosis. 2006 Oct;11(10):1709-26 [16951923] Immunol Rev. 2006 Oct;213:159-79 [16972903] J Immunol. 2006 Oct 15;177(8):5269-77 [17015712] Parasitology. 2006;132 Suppl:S61-8 [17018166] Autoimmunity. 2007 Jun;40(4):349-52 [17516227] J Leukoc Biol. 2007 Aug;82(2):288-99 [17449725] Comment In: Science. 2008 Aug 15;321(5891):917-8 [18703727] Erratum In: Science. 2008 Dec 12;322(5908):1634 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1126/science.1159194 ER - TY - JOUR T1 - Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant. AN - 69416205; 18698048 AB - We have previously reported on the safety and immunologic response of a poxvirus-based vaccine encoding prostate-specific antigen (PSA) used in combination with radiation therapy in patients with localized prostate cancer. We hypothesized that a "metronomic" dose of interleukin 2 (IL-2) as a biological adjuvant would cause less toxicity while maintaining immunologic response. Eighteen patients with localized prostate cancer were treated in a single-arm trial using previously established doses of vaccine and radiation therapy. The vaccine used was a recombinant vaccinia virus engineered to encode PSA admixed with a recombinant vaccinia encoding the costimulatory molecule B7.1, followed by booster vaccinations with a recombinant fowlpox vector expressing PSA. Patients received a total of eight planned vaccination cycles, once every 4 weeks, with granulocyte-macrophage colony-stimulating factor given on days 1 to 4 and interleukin 2 (IL-2) at a dose of 0.6 MIU/M2 given from days 8 to 21 after each vaccination. Definitive external beam radiation therapy was initiated after the third vaccination cycle. Patients were evaluated for safety and immunologic response. Toxicity and immunologic activity were compared with the previously reported regimen containing a higher dose of IL-2. Seventeen of 18 patients received all eight cycles of vaccine with IL-2. Five of eight HLA-A2+ patients evaluated had an increase in PSA-specific T cells of > or =3-fold. Toxicities were generally mild, with only seven vaccination cycles of 140 given resulting in grade 3 toxicities possibly attributable to IL-2. Metronomic-dose IL-2 in combination with vaccine and radiation therapy is safe, can induce prostate-specific immune responses, and has immunologic activity similar to low-dose IL-2, with markedly reduced toxicities. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Lechleider, Robert J AU - Arlen, Philip M AU - Tsang, Kwong-Yok AU - Steinberg, Seth M AU - Yokokawa, Junko AU - Cereda, Vittore AU - Camphausen, Kevin AU - Schlom, Jeffrey AU - Dahut, William L AU - Gulley, James L AD - Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 5284 EP - 5291 VL - 14 IS - 16 SN - 1078-0432, 1078-0432 KW - Adjuvants, Immunologic KW - 0 KW - Cancer Vaccines KW - Interleukin-2 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Vaccinia virus -- genetics KW - Granulocyte-Macrophage Colony-Stimulating Factor -- immunology KW - T-Lymphocytes, Regulatory -- drug effects KW - Combined Modality Therapy KW - Fowlpox virus -- genetics KW - Humans KW - Radiotherapy KW - Aged KW - Killer Cells, Natural -- drug effects KW - Granulocyte-Macrophage Colony-Stimulating Factor -- administration & dosage KW - Genetic Vectors KW - Middle Aged KW - Flow Cytometry KW - Granulocyte-Macrophage Colony-Stimulating Factor -- adverse effects KW - Killer Cells, Natural -- immunology KW - Male KW - T-Lymphocytes, Regulatory -- immunology KW - Cancer Vaccines -- administration & dosage KW - Prostatic Neoplasms -- immunology KW - Interleukin-2 -- adverse effects KW - Interleukin-2 -- administration & dosage KW - Cancer Vaccines -- immunology KW - Adjuvants, Immunologic -- administration & dosage KW - Cancer Vaccines -- adverse effects KW - Prostate-Specific Antigen -- immunology KW - Interleukin-2 -- immunology KW - Prostatic Neoplasms -- therapy KW - Adjuvants, Immunologic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69416205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Safety+and+immunologic+response+of+a+viral+vaccine+to+prostate-specific+antigen+in+combination+with+radiation+therapy+when+metronomic-dose+interleukin+2+is+used+as+an+adjuvant.&rft.au=Lechleider%2C+Robert+J%3BArlen%2C+Philip+M%3BTsang%2C+Kwong-Yok%3BSteinberg%2C+Seth+M%3BYokokawa%2C+Junko%3BCereda%2C+Vittore%3BCamphausen%2C+Kevin%3BSchlom%2C+Jeffrey%3BDahut%2C+William+L%3BGulley%2C+James+L&rft.aulast=Lechleider&rft.aufirst=Robert&rft.date=2008-08-15&rft.volume=14&rft.issue=16&rft.spage=5284&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-5162 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-08-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 1996 Mar 1;183(3):721-4 [8642275] Urology. 1997 Jul;50(1):93-9 [9218025] N Engl J Med. 1997 Jul 31;337(5):295-300 [9233866] J Clin Invest. 1998 Mar 15;101(6):1373-8 [9502779] J Urol. 1998 Jun;159(6):2030-4 [9598512] Cancer Immunol Immunother. 1998 Aug;46(6):318-26 [9756416] Cancer Res. 1999 Apr 1;59(7):1445-8 [10197611] Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1285-90 [15817329] Clin Cancer Res. 2005 May 1;11(9):3353-62 [15867235] Clin Cancer Res. 2005 Jun 15;11(12):4533-44 [15958639] Cancer Immunol Immunother. 2005 Sep;54(9):926-31 [15906025] Nat Med. 2005 Nov;11(11):1238-43 [16227988] J Clin Oncol. 2006 Mar 1;24(7):1169-77 [16505437] J Urol. 2006 Aug;176(2):544-7 [16813885] Clin Cancer Res. 2006 Jul 1;12(13):3993-6 [16818697] Nat Rev Immunol. 2006 Aug;6(8):595-601 [16868550] Clin Cancer Res. 2007 Apr 1;13(7):2100-8 [17404092] Front Biosci. 2007;12:4957-71 [17569623] Clin Cancer Res. 2008 Feb 15;14(4):1032-40 [18281535] J Clin Invest. 1993 Jan;91(1):123-32 [7678599] N Engl J Med. 1999 Dec 9;341(24):1781-8 [10588962] Clin Immunol. 2000 Mar;94(3):153-9 [10692234] J Urol. 2000 Apr;163(4):1155-60 [10737486] J Clin Invest. 2000 Jul;106(1):117-24 [10880055] Stat Med. 2001 Mar 30;20(6):859-66 [11252008] AIDS. 2001 Sep 28;15(14):1765-75 [11579237] HIV Clin Trials. 2000 Nov-Dec;1(3):1-15 [11590500] Lancet Oncol. 2001 Dec;2(12):733-40 [11902515] Lancet. 2002 Jul 13;360(9327):103-6 [12126818] Nat Rev Cancer. 2004 Jun;4(6):423-36 [15170445] Cancer Res. 2004 Jun 15;64(12):4328-37 [15205348] Blood. 2004 Aug 1;104(3):895-903 [15090447] Semin Surg Oncol. 1989;5(6):385-90 [2688029] J Urol. 1990 Nov;144(5):1180-4 [2231891] J Clin Oncol. 1991 Dec;9(12):2110-9 [1960552] Int J Cancer. 1995 Oct 9;63(2):231-7 [7591210] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-5162 ER - TY - JOUR T1 - Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. AN - 69409579; 18519566 AB - The crystal structure of a 1:1 complex between the German cockroach allergen Bla g 2 and the Fab' fragment of a monoclonal antibody 7C11 was solved at 2.8-angstroms resolution. Bla g 2 binds to the antibody through four loops that include residues 60-70, 83-86, 98-100, and 129-132. Cation-pi interactions exist between Lys-65, Arg-83, and Lys-132 in Bla g 2 and several tyrosines in 7C11. In the complex with Fab', Bla g 2 forms a dimer, which is stabilized by a quasi-four-helix bundle comprised of an alpha-helix and a helical turn from each allergen monomer, exhibiting a novel dimerization mode for an aspartic protease. A disulfide bridge between C51a and C113, unique to the aspartic protease family, connects the two helical elements within each Bla g 2 monomer, thus facilitating formation of the bundle. Mutation of these cysteines, as well as the residues Asn-52, Gln-110, and Ile-114, involved in hydrophobic interactions within the bundle, resulted in a protein that did not dimerize. The mutant proteins induced less beta-hexosaminidase release from mast cells than the wild-type Bla g 2, suggesting a functional role of dimerization in allergenicity. Because 7C11 shares a binding epitope with IgE, the information gained by analysis of the crystal structure of its complex provided guidance for site-directed mutagenesis of the allergen epitope. We have now identified key residues involved in IgE antibody binding; this information will be useful for the design of vaccines for immunotherapy. JF - The Journal of biological chemistry AU - Li, Mi AU - Gustchina, Alla AU - Alexandratos, Jerry AU - Wlodawer, Alexander AU - Wünschmann, Sabina AU - Kepley, Christopher L AU - Chapman, Martin D AU - Pomés, Anna AD - Macromolecular Crystallography Laboratory, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 22806 EP - 22814 VL - 283 IS - 33 SN - 0021-9258, 0021-9258 KW - Antibodies, Monoclonal KW - 0 KW - Insect Proteins KW - Recombinant Proteins KW - Tyrosine KW - 42HK56048U KW - Arginine KW - 94ZLA3W45F KW - Aspartic Acid Endopeptidases KW - EC 3.4.23.- KW - allergen Bla g 2 KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Animals KW - Dimerization KW - Humans KW - Insect Proteins -- immunology KW - Hypersensitivity KW - Insect Proteins -- chemistry KW - Recombinant Proteins -- immunology KW - Crystallography, X-Ray KW - Recombinant Proteins -- chemistry KW - Aspartic Acid Endopeptidases -- genetics KW - Cockroaches -- immunology KW - Aspartic Acid Endopeptidases -- chemistry KW - Aspartic Acid Endopeptidases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69409579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Crystal+structure+of+a+dimerized+cockroach+allergen+Bla+g+2+complexed+with+a+monoclonal+antibody.&rft.au=Li%2C+Mi%3BGustchina%2C+Alla%3BAlexandratos%2C+Jerry%3BWlodawer%2C+Alexander%3BW%C3%BCnschmann%2C+Sabina%3BKepley%2C+Christopher+L%3BChapman%2C+Martin+D%3BPom%C3%A9s%2C+Anna&rft.aulast=Li&rft.aufirst=Mi&rft.date=2008-08-15&rft.volume=283&rft.issue=33&rft.spage=22806&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M800937200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-03 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2NR6; PDB N1 - SuppNotes - Cited By: Eur J Biochem. 1997 Apr 15;245(2):334-9 [9151961] N Engl J Med. 1997 May 8;336(19):1356-63 [9134876] Thorax. 1999 Aug;54(8):675-80 [10413718] FASEB J. 1999 Aug;13(11):1277-90 [10428753] Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9459-64 [10449714] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Allergy Clin Immunol. 2005 Apr;115(4):803-9 [15806002] J Mol Biol. 2005 Apr 29;348(2):433-44 [15811379] J Allergy Clin Immunol. 2005 Jul;116(1):140-5 [15990787] J Allergy Clin Immunol. 2006 Mar;117(3):571-6 [16522455] J Allergy Clin Immunol. 2007 Apr;119(4):944-51 [17292955] J Mol Biol. 2007 May 4;368(3):742-52 [17374540] Acta Crystallogr D Biol Crystallogr. 2007 May;63(Pt 5):611-20 [17452786] J Mol Biol. 2007 Jul 20;370(4):714-27 [17543334] Structure. 2007 Nov;15(11):1413-21 [17997967] J Immunol. 2000 Jun 1;164(11):5844-9 [10820263] J Immunol. 2000 Jul 1;165(1):331-8 [10861069] J Biol Chem. 2000 Jul 14;275(28):21572-7 [10787420] Proteins. 2000 Oct 1;41(1):47-57 [10944393] J Immunol. 2000 Oct 1;165(7):3849-59 [11034391] J Allergy Clin Immunol. 2001 Mar;107(3):419-28 [11240940] Am J Respir Crit Care Med. 2002 Feb 1;165(3):391-7 [11818327] Eur J Biochem. 2002 Jun;269(12):3086-92 [12071974] J Immunol. 2003 Sep 15;171(6):3084-90 [12960334] Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):432-8 [14993666] J Biol Chem. 2004 Aug 20;279(34):35139-49 [15151996] Protein Eng Des Sel. 2004 May;17(5):463-72 [15310840] J Biol Chem. 1988 Aug 5;263(22):10541-4 [2455717] J Mol Biol. 1990 Jul 5;214(1):143-70 [2115087] Protein Eng. 1992 Apr;5(3):191-5 [1409538] J Biol Chem. 1995 Aug 18;270(33):19563-8 [7642642] Protein Eng. 1996 Oct;9(10):849-56 [8931124] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M800937200 ER - TY - JOUR T1 - Influence of antiretroviral drugs on the pharmacokinetics of prednisolone in HIV-infected individuals. AN - 69369288; 18645517 AB - Corticosteroids are cytochrome P450 3A4 substrates, which have been associated with toxicities in patients receiving cytochrome P450 3A4 inhibitors such as human immunodeficiency virus protease inhibitors. In a study in healthy volunteers, ritonavir significantly increased prednisolone exposure. We investigated the influence of antiretroviral (ARV) medications on prednisolone pharmacokinetics in 3 groups of 10 human immunodeficiency virus-infected subjects. One group received lopinavir/ritonavir, and another efavirenz, as part of their ARV regimen; a third group did not receive ARV medications. Each subject received a single 20-mg prednisone dose followed by serial blood sampling for prednisolone. Prednisolone pharmacokinetics were compared among the groups. Area under the concentration-time curve was significantly lower in efavirenz recipients versus subjects receiving lopinavir/ritonavir (geometric mean ratio = 0.60, P = 0.01). Average prednisolone area under the concentration-time curve was higher in subjects taking lopinavir/ritonavir versus subjects not on ARVs; however, this difference was not significant (P > 0.05). These data indicate that prednisolone concentrations may fluctuate widely when human immunodeficiency virus-positive individuals established on efavirenz therapy change to lopinavir/ritonavir or vice versa. JF - Journal of acquired immune deficiency syndromes (1999) AU - Busse, Kristin H AU - Formentini, Elizabeth AU - Alfaro, Raul M AU - Kovacs, Joseph A AU - Penzak, Scott R AD - Pharmacy Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 561 EP - 566 VL - 48 IS - 5 SN - 1525-4135, 1525-4135 KW - Anti-HIV Agents KW - 0 KW - Benzoxazines KW - HIV Protease Inhibitors KW - Pyrimidinones KW - Reverse Transcriptase Inhibitors KW - Lopinavir KW - 2494G1JF75 KW - Prednisolone KW - 9PHQ9Y1OLM KW - efavirenz KW - JE6H2O27P8 KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - AIDS/HIV KW - Drug Interactions KW - Reverse Transcriptase Inhibitors -- administration & dosage KW - Reverse Transcriptase Inhibitors -- pharmacology KW - Humans KW - Adult KW - HIV Protease Inhibitors -- pharmacology KW - Middle Aged KW - HIV Protease Inhibitors -- therapeutic use KW - Reverse Transcriptase Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- administration & dosage KW - Male KW - Female KW - Pyrimidinones -- administration & dosage KW - Prednisolone -- pharmacokinetics KW - HIV Infections -- virology KW - Ritonavir -- administration & dosage KW - Pyrimidinones -- therapeutic use KW - Anti-HIV Agents -- administration & dosage KW - Ritonavir -- therapeutic use KW - Anti-HIV Agents -- therapeutic use KW - Benzoxazines -- therapeutic use KW - Ritonavir -- pharmacology KW - Anti-HIV Agents -- pharmacology KW - Pyrimidinones -- pharmacology KW - HIV Infections -- drug therapy KW - HIV Infections -- metabolism KW - Prednisolone -- administration & dosage KW - Benzoxazines -- administration & dosage KW - Benzoxazines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69369288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Influence+of+antiretroviral+drugs+on+the+pharmacokinetics+of+prednisolone+in+HIV-infected+individuals.&rft.au=Busse%2C+Kristin+H%3BFormentini%2C+Elizabeth%3BAlfaro%2C+Raul+M%3BKovacs%2C+Joseph+A%3BPenzak%2C+Scott+R&rft.aulast=Busse&rft.aufirst=Kristin&rft.date=2008-08-15&rft.volume=48&rft.issue=5&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/10.1097%2FQAI.0b013e31817bebeb LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-04 N1 - Date created - 2008-07-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1997 May 3;349(9061):1294 [9142067] Sex Transm Infect. 1999 Aug;75(4):274 [10615321] AIDS. 2007 Feb 19;21(4):529-32 [17301576] J Acquir Immune Defic Syndr. 2005 Jul 1;39(3):307-12 [15980690] J Bone Joint Surg Br. 1977 Aug;59(3):308-17 [893509] Hopkins HIV Rep. 1999 Jul;11(4):9-12 [11366924] Clin Pharmacokinet. 1990 Aug;19(2):126-46 [2199128] J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):573-80 [16284534] J Chromatogr B Biomed Sci Appl. 2000 Jun 9;742(2):303-13 [10901135] Clin Infect Dis. 2002 Sep 15;35(6):E69-71 [12203188] AIDS. 1999 Sep 10;13(13):1803 [10509596] Lancet. 1987 Apr 18;1(8538):902-6 [2882300] Pediatr Transplant. 1999 May;3(2):126-30 [10389134] N Engl J Med. 1998 Mar 26;338(13):853-60 [9516219] Pediatr Infect Dis J. 2006 Nov;25(11):1044-8 [17072128] Eur J Clin Pharmacol. 2007 May;63(5):479-83 [17345073] J Pediatr. 2006 Mar;148(3):386-8 [16615973] AIDS. 2003 Jan 3;17(1):1-9 [12478064] J Clin Psychopharmacol. 2003 Dec;23(6):652-6 [14624194] J Infect. 2002 Apr;44(3):194-5 [12099750] Ann Intern Med. 2002 Jul 2;137(1):17-25 [12093241] HIV Med. 2003 Apr;4(2):149-50 [12702137] Drug Metab Dispos. 1995 Jan;23(1):137-42 [7720517] AIDS Patient Care STDS. 2007 Jun;21(6):373-7 [17594245] J Clin Endocrinol Metab. 2005 Jul;90(7):4394-8 [15755851] Ann Pharmacother. 2007 Jul;41(7):1306-9 [17535841] Clin Pharmacol Ther. 1989 Apr;45(4):366-72 [2639662] J Acquir Immune Defic Syndr. 2000 Sep 1;25(1):19-25 [11064500] Intern Med J. 2005 Jan;35(1):67-8 [15667475] AIDS. 2005 Apr 29;19(7):740-1 [15821405] J Acquir Immune Defic Syndr. 2003 Mar 1;32(3):281-6 [12626887] J Steroid Biochem Mol Biol. 1997 Jul;62(4):345-52 [9408089] J Infect Dis. 2001 Aug 15;184(4):519-23 [11471113] Eur J Clin Pharmacol. 2000 Apr;56(1):57-60 [10853878] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/QAI.0b013e31817bebeb ER - TY - JOUR T1 - Cadmium generates reactive oxygen- and carbon-centered radical species in rats: insights from in vivo spin-trapping studies. AN - 69313449; 18501199 AB - Cadmium (Cd) is a known industrial and environmental pollutant. In the present work, an in vivo spin-trapping technique was used in conjunction with electron spin resonance (ESR) spectroscopy to investigate free radical generation in rats following administration of cadmium chloride (CdCl2, 40 micromol/kg) and the spin trapping agent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN, 1 g/kg). In Cd-treated rats, POBN radical adducts were formed in the liver, were excreted into the bile, and exhibited an ESR spectrum consistent with a carbon-centered radical species probably derived from endogenous lipids. Isotope substitution of dimethyl sulfoxide [(CH3)2SO] with 13C demonstrated methyl radical formation (POBN/*13CH3). This adduct indicated the production of hydroxyl radical, which reacted with [(13CH3)2SO] to form *13CH3, which then reacted with POBN to form POBN/*13CH3. Depletion of hepatic glutathione by diethyl maleate significantly increased free radical production, whereas inactivation of Kupffer cells by gadolinium chloride and chelation of iron by desferal inhibited it. Treatment with the xanthine oxidase inhibitor allopurinol, the catalase inhibitor aminobenzotriazole, or the cytochrome P450 inhibitor 3-amino-1,2,4-triazole had no effect. This is the first study to show Cd generation of reactive oxygen- and carbon-centered radical species by involvement of both iron mediation through iron-catalyzed reactions and activation of Kupffer cells, the resident liver macrophages. JF - Free radical biology & medicine AU - Liu, Jie AU - Qian, Steven Y AU - Guo, Qiong AU - Jiang, JinJie AU - Waalkes, Michael P AU - Mason, Ronald P AU - Kadiiska, Maria B AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 475 EP - 481 VL - 45 IS - 4 SN - 0891-5849, 0891-5849 KW - Reactive Oxygen Species KW - 0 KW - Spin Labels KW - Cadmium KW - 00BH33GNGH KW - Carbon KW - 7440-44-0 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Electron Spin Resonance Spectroscopy KW - Liver -- metabolism KW - Bile -- metabolism KW - Male KW - Iron -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Cadmium -- pharmacology KW - Carbon -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69313449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Cadmium+generates+reactive+oxygen-+and+carbon-centered+radical+species+in+rats%3A+insights+from+in+vivo+spin-trapping+studies.&rft.au=Liu%2C+Jie%3BQian%2C+Steven+Y%3BGuo%2C+Qiong%3BJiang%2C+JinJie%3BWaalkes%2C+Michael+P%3BMason%2C+Ronald+P%3BKadiiska%2C+Maria+B&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2008-08-15&rft.volume=45&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.04.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-07-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Free Radic Biol Med. 2004 Jun 1;36(11):1434-43 [15135180] Curr Med Chem. 2005;12(10):1161-208 [15892631] Toxicol Appl Pharmacol. 1984 Mar 15;72(3):530-8 [6710502] Toxicol Appl Pharmacol. 1984 Oct;76(1):150-60 [6484985] Fundam Appl Toxicol. 1985 Oct;5(5):806-15 [4065457] Toxicology. 1986 Sep;40(3):285-95 [3750329] In Vitro Cell Dev Biol. 1990 Jan;26(1):75-9 [2307641] Toxicology. 1992;72(3):281-90 [1585382] J Biochem Mol Toxicol. 2000;14(2):110-7 [10630425] Toxicol Appl Pharmacol. 2000 Jan 1;162(1):68-75 [10631129] Free Radic Biol Med. 2000 Jan 1;28(1):55-63 [10656291] Toxicol Appl Pharmacol. 2000 Mar 15;163(3):231-9 [10702362] Toxicology. 2000 Apr 14;145(2-3):159-71 [10771141] J Inorg Biochem. 2000 Apr;79(1-4):241-4 [10830873] Chem Res Toxicol. 2000 Nov;13(11):1187-91 [11087442] J Toxicol Environ Health A. 2001 Jan 12;62(1):47-56 [11205535] J Environ Pathol Toxicol Oncol. 2001;20(2):77-88 [11394715] Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13549-53 [11717423] Free Radic Biol Med. 2002 Mar 15;32(6):525-35 [11958953] Toxicol Appl Pharmacol. 2002 May 1;180(3):178-85 [12009857] Biometals. 2003 Mar;16(1):103-11 [12572670] Free Radic Biol Med. 2003 Mar 15;34(6):766-73 [12633753] Toxicol Lett. 2003 Dec 10;145(3):211-7 [14580892] Free Radic Biol Med. 2003 Nov 15;35(10):1330-40 [14607532] Free Radic Biol Med. 2003 Dec 15;35(12):1568-81 [14680680] Arch Toxicol. 1994;68(6):364-9 [8092928] Toxicol Appl Pharmacol. 1995 Apr;131(2):224-34 [7536360] Toxicology. 1995 Dec 15;104(1-3):25-33 [8560499] Toxicology. 1996 Sep 2;112(3):219-26 [8845042] Toxicol Lett. 1996 Dec;89(1):65-9 [8952713] Free Radic Biol Med. 1997;22(3):471-8 [8981039] Toxicology. 1997 Aug 15;121(2):155-64 [9230447] Biometals. 1998 Apr;11(2):153-7 [9542068] Toxicol Appl Pharmacol. 1998 Apr;149(2):203-9 [9571989] Chem Res Toxicol. 1998 Dec;11(12):1516-20 [9860496] Toxicol Appl Pharmacol. 1999 Feb 1;154(3):256-63 [9931285] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Toxicology. 1999 Mar 1;133(1):43-58 [10413193] Free Radic Biol Med. 2005 Jan 1;38(1):125-35 [15589381] Bull Mem Acad R Med Belg. 2004;159(5-6):358-66 [15693545] Toxicol Appl Pharmacol. 1982 Sep 15;65(2):302-13 [7179286] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.04.041 ER - TY - JOUR T1 - Effects of Interpregnancy Interval on Blood Pressure in Consecutive Pregnancies AN - 21257562; 11604282 AB - The lower risk of preeclampsia observed in parous women has prompted a hypothesis that cardiovascular adaptation from a first pregnancy has ongoing benefits which contribute to a reduced risk of preeclampsia in the second pregnancy. However, how the interpregnancy interval affects mean arterial pressure (MAP) as an indicator of cardiovascular adaptation in subsequent pregnancies has not been well studied. The authors examined the effect of interpregnancy interval on MAP in consecutive pregnancies using data from the Collaborative Perinatal Project (1959-1965) and a semiparametric random-effects regression model. Prenatal MAP measurements were available for 533 women with both first and second births. MAP was lower in the second pregnancy (by approximately 2 mmHg) for very short interpregnancy intervals. However, this difference diminished when the interval increased, and it totally disappeared for intervals longer than 2 years. The authors conclude that although MAP is lower in the second pregnancy than in the first pregnancy, the effect persists for only a short time. It is therefore unlikely that mechanisms involving MAP as an indicator of cardiovascular adaptation contribute appreciably to the reduced risk of preeclampsia in subsequent pregnancies. However, it does not rule out the possibility that other mechanisms of cardiovascular adaptation persist longer. JF - American Journal of Epidemiology AU - Mikolajczyk, Rafael T AU - Zhang, Jun AU - Ford, Jessie AU - Grewal, Jagteshwar Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 422 EP - 426 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK VL - 168 IS - 4 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - birth intervals KW - blood pressure KW - pre-eclampsia KW - pregnancy KW - risk reduction KW - prenatal experience KW - Pregnancy KW - adaptability KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21257562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Effects+of+Interpregnancy+Interval+on+Blood+Pressure+in+Consecutive+Pregnancies&rft.au=Mikolajczyk%2C+Rafael+T%3BZhang%2C+Jun%3BFord%2C+Jessie%3BGrewal%2C+Jagteshwar&rft.aulast=Mikolajczyk&rft.aufirst=Rafael&rft.date=2008-08-15&rft.volume=168&rft.issue=4&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwn115 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - risk reduction; prenatal experience; blood pressure; adaptability; Pregnancy DO - http://dx.doi.org/10.1093/aje/kwn115 ER - TY - JOUR T1 - Database indexing for production MegaBLAST searches AN - 21209073; 11604388 AB - Motivation: The BLAST software package for sequence comparison speeds up homology search by preprocessing a query sequence into a lookup table. Numerous research studies have suggested that preprocessing the database instead would give better performance. However, production usage of sequence comparison methods that preprocess the database has been limited to programs such as BLAT and SSAHA that are designed to find matches when query and database subsequences are highly similar.Results: We developed a new version of the MegaBLAST module of BLAST that does the initial phase of finding short seeds for matches by searching a database index. We also developed a program makembindex that preprocesses the database into a data structure for rapid seed searching. We show that the new 'indexed MegaBLAST' is faster than the 'non-indexed' version for most practical uses. We show that indexed MegaBLAST is faster than miBLAST, another implementation of BLAST nucleotide searching with a preprocessed database, for most of the 200 queries we tested. To deploy indexed MegaBLAST as part of NCBI'sWeb BLAST service, the storage of databases and the queueing mechanism were modified, so that some machines are now dedicated to serving queries for a specific database. The response time for such Web queries is now faster than it was when each computer handled queries for multiple databases.Availability: The code for indexed MegaBLAST is part of the blastn program in the NCBI C++ toolkit. The preprocessor program makembindex is also in the toolkit. Indexed MegaBLAST has been used in production on NCBI's Web BLAST service to search one version of the human and mouse genomes since October 2007. The Linux command-line executables for blastn and makembindex, documentation, and some query sets used to carry out the tests described below are available in the directory: ftp://ftp.ncbi.nlm.nih.gov/agarwala/indexed_megablast: Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Morgulis, Aleksandr AU - Coulouris, George AU - Raytselis, Yan AU - Madden, Thomas L AU - Agarwala, Richa AU - Schaeffer, Alejandro A Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 1757 EP - 1764 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 24 IS - 16 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Databases KW - Computer programs KW - Seeds KW - software KW - Data processing KW - Homology KW - Computers KW - Bioinformatics KW - Nucleotides KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21209073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Database+indexing+for+production+MegaBLAST+searches&rft.au=Morgulis%2C+Aleksandr%3BCoulouris%2C+George%3BRaytselis%2C+Yan%3BMadden%2C+Thomas+L%3BAgarwala%2C+Richa%3BSchaeffer%2C+Alejandro+A&rft.aulast=Morgulis&rft.aufirst=Aleksandr&rft.date=2008-08-15&rft.volume=24&rft.issue=16&rft.spage=1757&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn322 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Genomes; Computer programs; Databases; software; Seeds; Data processing; Homology; Computers; Bioinformatics; Nucleotides DO - http://dx.doi.org/10.1093/bioinformatics/btn322 ER - TY - JOUR T1 - A probe-density-based analysis method for array CGH data: simulation, normalization and centralization AN - 21207248; 11604402 AB - Motivation: Genomic instability is one of the fundamental factors in tumorigenesis and tumor progression. Many studies have shown that copy-number abnormalities at the DNA level are important in the pathogenesis of cancer. Array comparative genomic hybridization (aCGH), developed based on expression microarray technology, can reveal the chromosomal aberrations in segmental copies at a high resolution. However, due to the nature of aCGH, many standard expression data processing tools, such as data normalization, often fail to yield satisfactory results.Results: We demonstrated a novel aCGH normalization algorithm, which provides an accurate aCGH data normalization by utilizing the dependency of neighboring probe measurements in aCGH experiments. To facilitate the study, we have developed a hidden Markov model (HMM) to simulate a series of aCGH experiments with random DNA copy number alterations that are used to validate the performance of our normalization. In addition, we applied the proposed normalization algorithm to an aCGH study of lung cancer cell lines. By using the proposed algorithm, data quality and the reliability of experimental results are significantly improved, and the distinct patterns of DNA copy number alternations are observed among those lung cancer cell lines.Contact: chuangeyatntu.edu.twSupplementary information: Source codes and.gures may be found at http://ntumaps.cgm.ntu.edu.tw/aCGH_supplementary JF - Bioinformatics AU - Chen, Hung-I Harry AU - Hsu, Fang-Han AU - Jiang, Yuan AU - Tsai, Mong-Hsun AU - Yang, Pan-Chyr AU - Meltzer, Paul S AU - Chuang, Eric Y AU - Chen, Yidong AD - super(1)Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan 106, super(2)Research Center for Medical Excellence, National Taiwan University, Taipei, Taiwan 100, Republic of China, super(3)Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, super(4)Institute of Biotechnology, Center for Systems Biology and Bioinformatics, National Taiwan University, Taipei, Taiwan 106, super(5)College of Medicine, National Taiwan University, Taipei, Taiwan 100, super(6)Department of Life Science, National Taiwan University, Taipei, Taiwan 106, super(7)Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan 106 and super(8)Graduate Institute of Epidemiology, National Taiwan University, Taipei, Taiwan 106, Republic of China Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 1749 EP - 1756 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 24 IS - 16 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - DNA probes KW - Tumorigenesis KW - Algorithms KW - copy number KW - Tumor cell lines KW - Genomic instability KW - hidden Markov models KW - DNA KW - Bioinformatics KW - Chromosome aberrations KW - Lung cancer KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21207248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=A+probe-density-based+analysis+method+for+array+CGH+data%3A+simulation%2C+normalization+and+centralization&rft.au=Chen%2C+Hung-I+Harry%3BHsu%2C+Fang-Han%3BJiang%2C+Yuan%3BTsai%2C+Mong-Hsun%3BYang%2C+Pan-Chyr%3BMeltzer%2C+Paul+S%3BChuang%2C+Eric+Y%3BChen%2C+Yidong&rft.aulast=Chen&rft.aufirst=Hung-I&rft.date=2008-08-15&rft.volume=24&rft.issue=16&rft.spage=1749&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn321 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Tumor cell lines; Genomic instability; Data processing; hidden Markov models; DNA probes; Tumorigenesis; DNA; Algorithms; Bioinformatics; Chromosome aberrations; Lung cancer; copy number DO - http://dx.doi.org/10.1093/bioinformatics/btn321 ER - TY - JOUR T1 - Sequence analysis of GerM and SpoVS, uncharacterized bacterial 'sporulation' proteins with widespread phylogenetic distribution AN - 21190065; 11604407 AB - Sporulation in low-G+C gram-positive bacteria (Firmicutes) is an important survival mechanism that involves up to 150 genes, acting in a highly regulated manner. Many sporulation genes have close homologs in non-sporulating bacteria, including cyanobacteria, proteobacteria and spirochaetes, indicating that their products play a wider biological role. Most of them have been characterized as regulatory proteins or enzymes of peptidoglycan turnover; functions of others remain unknown but they are likely to have a general role in cell division and/or development. We have compiled a list of such widely conserved sporulation and germination proteins with poorly characterized functions, ranked them by the width of their phylogenetic distribution, and performed detailed sequence analysis and, where possible, structural modeling aimed at estimating their potential functions. Here we report the results of sequence analysis of Bacillus subtilis spore germination protein GerM, suggesting that it is a widespread cell development protein, whose function might involve binding to peptidoglycan. GerM consists of two tandem copies of a new domain (designated the GERMN domain) that forms phylum-specific fusions with two other newly described domains, GERMN-associated domains 1 and 2 (GMAD1 and GMAD2). Fold recognition reveals a b-propeller fold for GMAD1, while ab initio modeling suggests that GMAD2 adopts a fibronectin type III fold. SpoVS is predicted to adopt the AlbA archaeal chromatin protein fold, which suggests that it is a DNA-binding protein, most likely a novel transcriptional regulator.Contact: drigdenatliverpool.ac.ukSupplementary information: Supplementary data are available at ftp://ftp.ncbi.nih.gov/pub/galperin/Sporulation.html JF - Bioinformatics AU - Rigden, Daniel J AU - Galperin, Michael Y AD - super(1)School of Biological Sciences, University of Liverpool, Crown St, Liverpool L69 7ZB, UK and super(2)NCBI, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA Y1 - 2008/08/15/ PY - 2008 DA - 2008 Aug 15 SP - 1793 EP - 1797 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 24 IS - 16 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Bacillus subtilis KW - Data processing KW - Chromatin KW - Gram-positive bacteria KW - Fibronectin KW - DNA-binding protein KW - Spore germination KW - Sporulation KW - Enzymes KW - Transcription KW - Survival KW - peptidoglycans KW - Firmicutes KW - Proteobacteria KW - Cell division KW - Cyanobacteria KW - regulatory proteins KW - Conserved sequence KW - Bioinformatics KW - A 01490:Miscellaneous KW - J 02320:Cell Biology KW - G 07770:Bacteria KW - K 03320:Cell Biology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21190065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Sequence+analysis+of+GerM+and+SpoVS%2C+uncharacterized+bacterial+%27sporulation%27+proteins+with+widespread+phylogenetic+distribution&rft.au=Rigden%2C+Daniel+J%3BGalperin%2C+Michael+Y&rft.aulast=Rigden&rft.aufirst=Daniel&rft.date=2008-08-15&rft.volume=24&rft.issue=16&rft.spage=1793&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn314 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Phylogeny; Data processing; Chromatin; DNA-binding protein; Fibronectin; Gram-positive bacteria; Spore germination; Sporulation; peptidoglycans; Survival; Transcription; Enzymes; Cell division; regulatory proteins; Conserved sequence; Bioinformatics; Cyanobacteria; Bacillus subtilis; Firmicutes; Proteobacteria DO - http://dx.doi.org/10.1093/bioinformatics/btn314 ER - TY - JOUR T1 - Methoxylation enhances stilbene bioactivity in Caenorhabditis elegans. AN - 69531883; 18700960 AB - Stilbenes are 1,2-diphenylethylene congeners produced by plants in response to stress. Many stilbenes also exhibit xenobiotic activities in animal cells, such as inhibition of cancer cell growth, neuroprotection, and immune modulation. In vivo, hydroxylated stilbenes are metabolized by glucuronidation to facilitate excretion. Methoxylated stilbenes are metabolized more slowly, which may have a positive effect on in vivo bioactivity. Here, we have directly compared in vivo bioactivities of methoxylated and hydroxylated stilbenes in a whole organism using the roundworm Caenorhabditis elegans, an advantageous experimental system for such studies due to its rapid lifecycle, genetic amenability and relatively low-cost. Toxicity towards C. elegans adults was observed for trimethoxylated and dimethoxylated stilbenes, as well as the monomethoxylated stilbene desoxyrhapontigenin. Toxicity was not observed for the monomethoxylated stilbene, pinostilbene, nor for hydroxylated stilbenes. The methoxylated stilbenes that exhibited toxicity also showed stronger inhibitory effects than the hydroxylated stilbenes on germline tumor growth in gld-1(q485) adults. However, steady-state levels of three inhibitory methoxylated stilbenes did not directly correlate to their relative bioactivities. These findings demonstrate that, for the group of stilbenes investigated, methoxylation generally increased bioactivity in vivo in a whole organism, with the exception of pinostilbene. Differences in bioactivity in C. elegans adults did not appear to correlate with differential uptake. Rather, we speculate that methoxylated stilbenes may have increased interactions with biological targets in vivo or may interact with specific targets unaffected by hydroxylated stilbenes. The potent activities of methoxylated stilbenes provide a basis for further investigations to identify in vivo targets for these compounds. JF - BMC pharmacology AU - Wilson, Mark A AU - Rimando, Agnes M AU - Wolkow, Catherine A AD - Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, NIH, Baltimore, MD 21224, USA. wilsonma@grc.nia.nih.gov Y1 - 2008/08/13/ PY - 2008 DA - 2008 Aug 13 SP - 15 VL - 8 KW - Antineoplastic Agents KW - 0 KW - Stilbenes KW - Index Medicus KW - Animals KW - Tumor Burden -- drug effects KW - Caenorhabditis elegans -- drug effects KW - Germ-Line Mutation KW - Animals, Genetically Modified KW - Hydroxylation KW - Caenorhabditis elegans -- genetics KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Stilbenes -- chemistry KW - Antineoplastic Agents -- toxicity KW - Stilbenes -- toxicity KW - Stilbenes -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69531883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+pharmacology&rft.atitle=Methoxylation+enhances+stilbene+bioactivity+in+Caenorhabditis+elegans.&rft.au=Wilson%2C+Mark+A%3BRimando%2C+Agnes+M%3BWolkow%2C+Catherine+A&rft.aulast=Wilson&rft.aufirst=Mark&rft.date=2008-08-13&rft.volume=8&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=BMC+pharmacology&rft.issn=1471-2210&rft_id=info:doi/10.1186%2F1471-2210-8-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Jun 22;276(25):22586-94 [11316812] Phytother Res. 2008 Feb;22(2):169-79 [17726731] Development. 2003 Mar;130(6):1089-99 [12571101] Bioorg Med Chem Lett. 2004 Jul 16;14(14):3841-5 [15203173] Nature. 2004 Aug 5;430(7000):686-9 [15254550] Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12980-5 [15328413] Proc Natl Acad Sci U S A. 1972 Jul;69(7):1855-7 [4505665] Genetics. 1974 May;77(1):71-94 [4366476] Dev Biol. 1978 Oct;66(2):386-409 [700253] Exp Gerontol. 1978;13(5):369-74 [153845] Dev Biol. 1984 Nov;106(1):223-35 [6541600] J Nat Prod. 1994 Jul;57(7):896-904 [7525878] Genetics. 1995 Feb;139(2):579-606 [7713419] Genetics. 1995 Feb;139(2):607-30 [7713420] Int J Oncol. 1998 Apr;12(4):865-9 [9499448] Nature. 1957 Mar 30;179(4561):663-6 [13418758] Neoplasia. 2005 Jan;7(1):37-47 [15736313] J Agric Food Chem. 2005 May 4;53(9):3403-7 [15853379] Mol Nutr Food Res. 2005 May;49(5):472-81 [15779070] Aging Cell. 2006 Feb;5(1):59-68 [16441844] Xenobiotica. 2006 Apr;36(4):269-85 [16684708] Life Sci. 2006 Jul 10;79(7):641-5 [16616938] Xenobiotica. 2006 May;36(5):387-97 [16854778] Drug Metab Dispos. 2006 Oct;34(10):1786-92 [16868069] Bioorg Med Chem Lett. 2006 Nov 1;16(21):5650-3 [16919455] J Neurosci. 2006 Dec 13;26(50):13102-13 [17167099] Cell. 2006 Dec 15;127(6):1109-22 [17112576] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):98-101 [17220336] Biochem Pharmacol. 2007 May 1;73(9):1288-96 [17250812] Mol Nutr Food Res. 2007 May;51(5):517-24 [17440990] Z Naturforsch C. 2007 Mar-Apr;62(3-4):189-95 [17542483] J Mol Biol. 2007 Jun 29;370(1):1-13 [17499272] Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1621-5 [17684136] Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4232-9 [17724212] Life Sci. 2007 Aug 23;81(11):873-83 [17764700] J Agric Food Chem. 2002 Jun 5;50(12):3453-7 [12033810] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2210-8-15 ER - TY - JOUR T1 - Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria. AN - 69425248; 18698359 AB - Apical Membrane Antigen 1 (AMA1), a polymorphic merozoite surface protein, is a leading blood-stage malaria vaccine candidate. This is the first reported use in humans of an investigational vaccine, AMA1-C1/Alhydrogel, with the novel adjuvant CPG 7909. A phase 1 trial was conducted at the University of Rochester with 75 malaria-naive volunteers to assess the safety and immunogenicity of the AMA1-C1/Alhydrogel+CPG 7909 malaria vaccine. Participants were sequentially enrolled and randomized within dose escalating cohorts to receive three vaccinations on days 0, 28 and 56 of either 20 microg of AMA1-C1/Alhydrogel+564 microg CPG 7909 (n = 15), 80 microg of AMA1-C1/Alhydrogel (n = 30), or 80 microg of AMA1-C1/Alhydrogel+564 microg CPG 7909 (n = 30). Local and systemic adverse events were significantly more likely to be of higher severity with the addition of CPG 7909. Anti-AMA1 immunoglobulin G (IgG) were detected by enzyme-linked immunosorbent assay (ELISA), and the immune sera of volunteers that received 20 microg or 80 microg of AMA1-C1/Alhydrogel+CPG 7909 had up to 14 fold significant increases in anti-AMA1 antibody concentration compared to 80 microg of AMA1-C1/Alhydrogel alone. The addition of CPG 7909 to the AMA1-C1/Alhydrogel vaccine in humans also elicited AMA1 specific immune IgG that significantly and dramatically increased the in vitro growth inhibition of homologous parasites to levels as high as 96% inhibition. The safety profile of the AMA1-C1/Alhydrogel+CPG 7909 malaria vaccine is acceptable, given the significant increase in immunogenicity observed. Further clinical development is ongoing. ClinicalTrials.gov NCT00344539. JF - PloS one AU - Mullen, Gregory E D AU - Ellis, Ruth D AU - Miura, Kazutoyo AU - Malkin, Elissa AU - Nolan, Caroline AU - Hay, Mhorag AU - Fay, Michael P AU - Saul, Allan AU - Zhu, Daming AU - Rausch, Kelly AU - Moretz, Samuel AU - Zhou, Hong AU - Long, Carole A AU - Miller, Louis H AU - Treanor, John AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America. greg.mullen@kcl.ac.uk Y1 - 2008/08/13/ PY - 2008 DA - 2008 Aug 13 SP - 1 VL - 3 IS - 8 KW - Antigens, Protozoan KW - 0 KW - Malaria Vaccines KW - Membrane Proteins KW - Oligodeoxyribonucleotides KW - ProMune KW - Protozoan Proteins KW - apical membrane antigen I, Plasmodium KW - Aluminum Hydroxide KW - 5QB0T2IUN0 KW - Index Medicus KW - Animals KW - Membrane Proteins -- immunology KW - Humans KW - Safety KW - Adult KW - Middle Aged KW - Protozoan Proteins -- toxicity KW - Oligodeoxyribonucleotides -- toxicity KW - Adolescent KW - Membrane Proteins -- toxicity KW - Aluminum Hydroxide -- toxicity KW - Protozoan Proteins -- immunology KW - Antigens, Protozoan -- toxicity KW - Antigens, Protozoan -- immunology KW - Malaria Vaccines -- toxicity KW - Plasmodium falciparum -- immunology KW - Malaria, Falciparum -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69425248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Phase+1+trial+of+AMA1-C1%2FAlhydrogel+plus+CPG+7909%3A+an+asexual+blood-stage+vaccine+for+Plasmodium+falciparum+malaria.&rft.au=Mullen%2C+Gregory+E+D%3BEllis%2C+Ruth+D%3BMiura%2C+Kazutoyo%3BMalkin%2C+Elissa%3BNolan%2C+Caroline%3BHay%2C+Mhorag%3BFay%2C+Michael+P%3BSaul%2C+Allan%3BZhu%2C+Daming%3BRausch%2C+Kelly%3BMoretz%2C+Samuel%3BZhou%2C+Hong%3BLong%2C+Carole+A%3BMiller%2C+Louis+H%3BTreanor%2C+John&rft.aulast=Mullen&rft.aufirst=Gregory+E&rft.date=2008-08-13&rft.volume=3&rft.issue=8&rft.spage=e2940&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0002940 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-18 N1 - Date created - 2008-08-13 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00344539; ClinicalTrials.gov N1 - SuppNotes - Cited By: Infect Immun. 2000 May;68(5):2899-906 [10768987] Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7857-62 [18515425] Genetics. 2001 Aug;158(4):1505-12 [11514442] Clin Lab Med. 2002 Jun;22(2):447-74 [12134471] Infect Immun. 2002 Oct;70(10):5751-8 [12228305] Infect Immun. 2002 Dec;70(12):6948-60 [12438374] Infect Immun. 2002 Dec;70(12):6961-7 [12438375] Vaccine. 2004 Aug 13;22(23-24):3136-43 [15297066] Best Pract Res Clin Obstet Gynaecol. 2004 Oct;18(5):755-71 [15380145] Parasite Immunol. 1988 Sep;10(5):535-52 [3194149] Am J Med. 1991 Nov;91(5):528-34 [1951415] Am J Trop Med Hyg. 1994 Dec;51(6):711-9 [7810803] Mol Biochem Parasitol. 1996 Apr;77(1):109-13 [8784778] Vaccine. 1998 Jan-Feb;16(2-3):240-7 [9607037] J Immunother. 2004 Nov-Dec;27(6):460-71 [15534490] J Clin Immunol. 2004 Nov;24(6):693-701 [15622454] Infect Immun. 2005 Jun;73(6):3677-85 [15908397] AIDS. 2005 Sep 23;19(14):1473-9 [16135900] Vaccine. 2006 Mar 24;24(14):2497-505 [16434128] Expert Rev Vaccines. 2006 Jun;5(3):365-9 [16827620] Vaccine. 2007 Feb 19;25(9):1567-80 [17045367] Curr Opin Mol Ther. 2007 Feb;9(1):12-24 [17330398] J Immunol Methods. 2007 Jun 30;323(2):139-46 [17512533] Vaccine. 2007 Jul 20;25(29):5343-7 [17566616] Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12488-93 [17636123] PLoS One. 2007;2(10):e1045 [17940609] Vaccine. 2008 Jan 10;26(2):193-200 [18054414] Trends Parasitol. 2008 Feb;24(2):74-84 [18226584] PLoS One. 2008;3(2):e1563 [18270560] Infect Immun. 2008 Jun;76(6):2660-70 [18378635] Mol Biochem Parasitol. 2001 Apr 6;113(2):279-87 [11295182] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0002940 ER - TY - JOUR T1 - Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. AN - 69424529; 18678913 AB - Ascorbic acid is an essential nutrient commonly regarded as an antioxidant. In this study, we showed that ascorbate at pharmacologic concentrations was a prooxidant, generating hydrogen-peroxide-dependent cytotoxicity toward a variety of cancer cells in vitro without adversely affecting normal cells. To test this action in vivo, normal oral tight control was bypassed by parenteral ascorbate administration. Real-time microdialysis sampling in mice bearing glioblastoma xenografts showed that a single pharmacologic dose of ascorbate produced sustained ascorbate radical and hydrogen peroxide formation selectively within interstitial fluids of tumors but not in blood. Moreover, a regimen of daily pharmacologic ascorbate treatment significantly decreased growth rates of ovarian (P < 0.005), pancreatic (P < 0.05), and glioblastoma (P < 0.001) tumors established in mice. Similar pharmacologic concentrations were readily achieved in humans given ascorbate intravenously. These data suggest that ascorbate as a prodrug may have benefits in cancers with poor prognosis and limited therapeutic options. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Chen, Qi AU - Espey, Michael Graham AU - Sun, Andrew Y AU - Pooput, Chaya AU - Kirk, Kenneth L AU - Krishna, Murali C AU - Khosh, Deena Beneda AU - Drisko, Jeanne AU - Levine, Mark AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, and Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/08/12/ PY - 2008 DA - 2008 Aug 12 SP - 11105 EP - 11109 VL - 105 IS - 32 KW - Antineoplastic Agents KW - 0 KW - Antioxidants KW - Oxidants KW - Prodrugs KW - Hydrogen Peroxide KW - BBX060AN9V KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Animals KW - Infusions, Intravenous KW - Hydrogen Peroxide -- metabolism KW - Humans KW - Antioxidants -- pharmacokinetics KW - Mice, Nude KW - Mice KW - Female KW - Antioxidants -- administration & dosage KW - Neoplasms -- drug therapy KW - Ascorbic Acid -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Antineoplastic Agents -- pharmacokinetics KW - Xenograft Model Antitumor Assays KW - Prodrugs -- pharmacokinetics KW - Oxidants -- pharmacokinetics KW - Oxidants -- administration & dosage KW - Ascorbic Acid -- metabolism KW - Prodrugs -- administration & dosage KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69424529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Pharmacologic+doses+of+ascorbate+act+as+a+prooxidant+and+decrease+growth+of+aggressive+tumor+xenografts+in+mice.&rft.au=Chen%2C+Qi%3BEspey%2C+Michael+Graham%3BSun%2C+Andrew+Y%3BPooput%2C+Chaya%3BKirk%2C+Kenneth+L%3BKrishna%2C+Murali+C%3BKhosh%2C+Deena+Beneda%3BDrisko%2C+Jeanne%3BLevine%2C+Mark&rft.aulast=Chen&rft.aufirst=Qi&rft.date=2008-08-12&rft.volume=105&rft.issue=32&rft.spage=11105&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0804226105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-16 N1 - Date created - 2008-08-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Am Coll Nutr. 2000 Aug;19(4):423-5 [10963459] CMAJ. 2006 Mar 28;174(7):937-42 [16567755] Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):715-20 [11805326] J Am Coll Nutr. 2003 Feb;22(1):18-35 [12569111] Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):243-70 [16677071] Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1205-16 [16910768] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54 [17502596] Curr Med Chem. 2007;14(17):1853-62 [17627521] Clin Cancer Res. 2007 Dec 15;13(24):7441-50 [18094428] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9842-6 [11504949] N Engl J Med. 1979 Sep 27;301(13):687-90 [384241] N Engl J Med. 1985 Jan 17;312(3):137-41 [3880867] N Engl J Med. 1985 Jan 17;312(3):178-9 [3965937] Annu Rev Nutr. 1986;6:365-406 [3015170] J Immunol Methods. 1994 Apr 15;170(2):211-24 [8157999] Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3704-9 [8623000] Cancer Biochem Biophys. 1998 Jun;16(1-2):17-30 [9923964] J Natl Cancer Inst. 1999 Mar 17;91(6):547-56 [10088626] J Natl Cancer Inst. 2004 Nov 3;96(21):1577-84 [15523086] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9 [16157892] Mol Ther. 2006 Jan;13(1):211-20 [16126008] Ann Intern Med. 2004 Apr 6;140(7):533-7 [15068981] Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9 [1068480] Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538-42 [279931] Comment In: Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11037-8 [18682554] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1073/pnas.0804226105 ER - TY - JOUR T1 - Neem leaf glycoprotein helps to generate carcinoembryonic antigen specific anti-tumor immune responses utilizing macrophage-mediated antigen presentation. AN - 69360682; 18590789 AB - In an objective to generate effective carcinoembryonic antigen (CEA) specific anti-tumor immune response in Swiss mice, CEA was presented using macrophages with adjuvant help from neem leaf glycoprotein (NLGP). Such vaccination generates significantly higher antibody (IgG2a) and T cell response than immunization protocol without NLGP. NLGP controls the function of both B cells and macrophages by altering the expressions of various regulatory molecules, like, CD19, CD11b, etc. NLGP also directs CEA vaccination towards Th1 bias, by modulating cytokine secretion. This NLGP-generated anti-CEA immune response would be effective as a vaccine to lyse CEA(+) tumors in vitro and in vivo. JF - Vaccine AU - Sarkar, Koustav AU - Bose, Anamika AU - Chakraborty, Krishnendu AU - Haque, Enamul AU - Ghosh, Diptendu AU - Goswami, Shyamal AU - Chakraborty, Tathagata AU - Laskar, Subrata AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, West Bengal, India. Y1 - 2008/08/12/ PY - 2008 DA - 2008 Aug 12 SP - 4352 EP - 4362 VL - 26 IS - 34 SN - 0264-410X, 0264-410X KW - Adjuvants, Immunologic KW - 0 KW - Antibodies, Neoplasm KW - Carcinoembryonic Antigen KW - Glycoproteins KW - Plant Proteins KW - Index Medicus KW - Antibodies, Neoplasm -- blood KW - Cytotoxicity, Immunologic KW - Animals KW - Cytotoxicity Tests, Immunologic KW - Azadirachta -- chemistry KW - Mice KW - Cell Line, Tumor KW - Plant Leaves -- chemistry KW - T-Lymphocytes -- immunology KW - Female KW - Survival Analysis KW - Cell Survival KW - Glycoproteins -- immunology KW - Antigen Presentation KW - Plant Proteins -- immunology KW - Neoplasms -- pathology KW - Macrophages -- immunology KW - Carcinoembryonic Antigen -- immunology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69360682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Neem+leaf+glycoprotein+helps+to+generate+carcinoembryonic+antigen+specific+anti-tumor+immune+responses+utilizing+macrophage-mediated+antigen+presentation.&rft.au=Sarkar%2C+Koustav%3BBose%2C+Anamika%3BChakraborty%2C+Krishnendu%3BHaque%2C+Enamul%3BGhosh%2C+Diptendu%3BGoswami%2C+Shyamal%3BChakraborty%2C+Tathagata%3BLaskar%2C+Subrata%3BBaral%2C+Rathindranath&rft.aulast=Sarkar&rft.aufirst=Koustav&rft.date=2008-08-12&rft.volume=26&rft.issue=34&rft.spage=4352&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.06.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-07 N1 - Date created - 2008-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2008.06.048 ER - TY - JOUR T1 - Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. AN - 69401959; 18636091 AB - NR3 subtype glutamate receptors have a unique developmental expression profile, but are the least well-characterized members of the NMDA receptor gene family, which have key roles in synaptic plasticity and brain development. Using ligand binding assays, crystallographic analysis, and all atom MD simulations, we investigate mechanisms underlying the binding by NR3A and NR3B of glycine and D-serine, which are candidate neurotransmitters for NMDA receptors containing NR3 subunits. The ligand binding domains of both NR3 subunits adopt a similar extent of domain closure as found in the corresponding NR1 complexes, but have a unique loop 1 structure distinct from that in all other glutamate receptor ion channels. Within their ligand binding pockets, NR3A and NR3B have strikingly different hydrogen bonding networks and solvent structures from those found in NR1, and fail to undergo a conformational rearrangement observed in NR1 upon binding the partial agonist ACPC. MD simulations revealed numerous interdomain contacts, which stabilize the agonist-bound closed-cleft conformation, and a novel twisting motion for the loop 1 helix that is unique in NR3 subunits. JF - The EMBO journal AU - Yao, Yongneng AU - Harrison, Chris B AU - Freddolino, Peter L AU - Schulten, Klaus AU - Mayer, Mark L AD - Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA. Y1 - 2008/08/06/ PY - 2008 DA - 2008 Aug 06 SP - 2158 EP - 2170 VL - 27 IS - 15 KW - Amino Acids, Cyclic KW - 0 KW - NR1 NMDA receptor KW - NR3A NMDA receptor KW - NR3B NMDA receptor KW - Receptors, N-Methyl-D-Aspartate KW - 1-aminocyclopropane-1-carboxylic acid KW - 3K9EJ633GL KW - Serine KW - 452VLY9402 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Glycine -- chemistry KW - Computer Simulation KW - Drug Partial Agonism KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Protein Binding KW - Hydrogen Bonding KW - Amino Acids, Cyclic -- metabolism KW - Serine -- chemistry KW - Receptors, N-Methyl-D-Aspartate -- agonists KW - Models, Molecular KW - Receptors, N-Methyl-D-Aspartate -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69401959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=Molecular+mechanism+of+ligand+recognition+by+NR3+subtype+glutamate+receptors.&rft.au=Yao%2C+Yongneng%3BHarrison%2C+Chris+B%3BFreddolino%2C+Peter+L%3BSchulten%2C+Klaus%3BMayer%2C+Mark+L&rft.aulast=Yao&rft.aufirst=Yongneng&rft.date=2008-08-06&rft.volume=27&rft.issue=15&rft.spage=2158&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=1460-2075&rft_id=info:doi/10.1038%2Femboj.2008.140 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-24 N1 - Date created - 2008-08-07 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2RCB; PDB; 2RCA; 2RC8; 2RC7; 2RC9 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Jul 14;275(28):21355-63 [10748170] Nat Struct Mol Biol. 2006 Dec;13(12):1120-7 [17115050] Acta Crystallogr D Biol Crystallogr. 2001 Jan;57(Pt 1):122-33 [11134934] J Neurosci. 2001 Feb 15;21(4):1228-37 [11160393] J Mol Biol. 2001 Aug 24;311(4):815-36 [11518533] Acta Crystallogr D Biol Crystallogr. 2001 Oct;57(Pt 10):1451-6 [11567159] J Neurosci. 2001 Dec 1;21(23):RC185 [11717388] Nature. 2002 Feb 14;415(6873):793-8 [11823786] J Neurophysiol. 2002 Apr;87(4):2052-63 [11929923] Nature. 2002 May 16;417(6886):245-53 [12015593] Proteins. 2003 Feb 15;50(3):437-50 [12557186] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5736-41 [12730367] EMBO J. 2003 Jun 16;22(12):2873-85 [12805203] Methods Enzymol. 2003;374:229-44 [14696376] J Pharmacol Exp Ther. 2007 Aug;322(2):739-48 [17502428] Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14116-21 [17715062] J Biol Chem. 2008 Jan 4;283(1):37-46 [17959602] J Neurosci. 2008 Jan 23;28(4):932-43 [18216201] J Comp Neurol. 2002 Sep 2;450(4):303-17 [12209845] J Comput Chem. 2004 Aug;25(11):1400-15 [15185334] Neurosci Lett. 1990 Nov 27;120(1):17-20 [2149877] EMBO J. 1995 Dec 15;14(24):6327-32 [8557052] Proteins. 1996 Apr;24(4):433-8 [9162944] Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13431-6 [9391042] Nature. 1998 May 28;393(6683):377-81 [9620802] Nature. 1998 Oct 29;395(6705):913-7 [9804426] Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):191-205 [10089410] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1708-13 [15677325] FEBS Lett. 2005 Feb 14;579(5):1154-60 [15710405] Neuron. 2005 Feb 17;45(4):539-52 [15721240] Eur J Neurosci. 2005 Mar;21(5):1432-6 [15813953] J Neurosci. 2005 Apr 13;25(15):3752-62 [15829627] Neuron. 2005 Jul 7;47(1):71-84 [15996549] J Neurosci. 2005 Aug 24;25(34):7858-66 [16120788] J Neurosci. 2005 Sep 28;25(39):9027-36 [16192394] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] Nature. 2005 Nov 10;438(7065):185-92 [16281028] Mol Pharmacol. 2006 Jan;69(1):11-8 [16219907] Acta Crystallogr D Biol Crystallogr. 2006 Apr;62(Pt 4):439-50 [16552146] J Neurosci. 2006 Apr 26;26(17):4559-66 [16641235] J Biol Chem. 2006 May 5;281(18):12736-42 [16513640] J Neurosci. 2006 Jul 19;26(29):7650-8 [16855092] Neuron. 2000 Oct;28(1):165-81 [11086992] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/emboj.2008.140 ER - TY - JOUR T1 - HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision. AN - 69398954; 18667707 AB - We previously proposed that mutations in the connection subdomain (cn) of HIV-1 reverse transcriptase increase AZT resistance by altering the balance between nucleotide excision and template RNA degradation. To test the predictions of this model, we analyzed the effects of previously identified cn mutations in combination with thymidine analog mutations (D67N, K70R, T215Y, and K219Q) on in vitro RNase H activity and AZT monophosphate (AZTMP) excision. We found that cn mutations G335C/D, N348I, A360I/V, V365I, and A376S decreased primary and secondary RNase H cleavages. The patient-derived cns increased ATP- and PPi-mediated AZTMP excision on an RNA template compared with a DNA template. One of 5 cns caused an increase in ATP-mediated AZTMP excision on a DNA template, whereas three cns showed a higher ratio of ATP- to PPi-mediated excision, indicating that some cn mutations also affect excision on a DNA substrate. Overall, the results strongly support the model that cn mutations increase AZT resistance by reducing template RNA degradation, thereby providing additional time for RT to excise AZTMP. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Delviks-Frankenberry, Krista A AU - Nikolenko, Galina N AU - Boyer, Paul L AU - Hughes, Stephen H AU - Coffin, John M AU - Jere, Abhay AU - Pathak, Vinay K AD - Viral Mutation Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2008/08/05/ PY - 2008 DA - 2008 Aug 05 SP - 10943 EP - 10948 VL - 105 IS - 31 KW - DNA Primers KW - 0 KW - Zidovudine KW - 4B9XT59T7S KW - RNA KW - 63231-63-0 KW - reverse transcriptase, Human immunodeficiency virus 1 KW - EC 2.7.7.- KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - Index Medicus KW - DNA Primers -- genetics KW - Humans KW - Cell Line KW - Mutagenesis KW - Cloning, Molecular KW - HIV Reverse Transcriptase -- genetics KW - Zidovudine -- metabolism KW - RNA -- metabolism KW - Drug Resistance, Viral -- genetics KW - Mutation -- genetics KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69398954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=HIV-1+reverse+transcriptase+connection+subdomain+mutations+reduce+template+RNA+degradation+and+enhance+AZT+excision.&rft.au=Delviks-Frankenberry%2C+Krista+A%3BNikolenko%2C+Galina+N%3BBoyer%2C+Paul+L%3BHughes%2C+Stephen+H%3BCoffin%2C+John+M%3BJere%2C+Abhay%3BPathak%2C+Vinay+K&rft.aulast=Delviks-Frankenberry&rft.aufirst=Krista&rft.date=2008-08-05&rft.volume=105&rft.issue=31&rft.spage=10943&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0804660105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 2000 Dec;44(12):3465-72 [11083661] PLoS One. 2008;3(3):e1781 [18335052] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10090-5 [12119402] J Biol Chem. 2002 Aug 9;277(32):28400-10 [12023278] Anal Biochem. 2003 Nov 1;322(1):33-9 [14705777] J Virol. 2004 Sep;78(18):9987-97 [15331732] Science. 1988 Nov 25;242(4882):1168-71 [2460924] Science. 1988 Nov 25;242(4882):1171-3 [2460925] Science. 1989 Dec 1;246(4934):1155-8 [2479983] J Infect Dis. 1992 Jan;165(1):105-10 [1370174] Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9564-8 [7937806] Nature. 1995 Jan 12;373(6510):117-22 [7529365] Nature. 1995 Jan 12;373(6510):123-6 [7816094] J Virol. 1995 Aug;69(8):5087-94 [7541846] Science. 1996 Mar 15;271(5255):1582-6 [8599114] J Virol. 1998 Jun;72(6):5093-8 [9573280] Biochemistry. 1998 Nov 10;37(45):15908-17 [9843396] Mol Cell. 1999 Jul;4(1):35-43 [10445025] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2093-8 [15684061] Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):317-22 [17179211] J Virol. 2007 Jul;81(13):6837-45 [17428874] J Virol. 2007 Aug;81(15):7852-9 [17507476] Top HIV Med. 2007 Aug-Sep;15(4):119-25 [17720996] PLoS Med. 2007 Dec;4(12):e335 [18052601] Antimicrob Agents Chemother. 2008 Jan;52(1):157-63 [17967907] Mol Pharmacol. 2008 Feb;73(2):601-6 [18024510] J Virol. 2008 Apr;82(7):3261-70 [18216099] J Virol. 2001 May;75(10):4832-42 [11312355] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0804660105 ER - TY - JOUR T1 - pathFinder: A Static Network Analysis Tool for Pharmacological Analysis of Signal Transduction Pathways AN - 20881001; 8407831 AB - The study of signal transduction is becoming a de facto part of the analysis of gene expression and protein profiling techniques. Many online tools are used to cluster genes in various ways or to assign gene products to signal transduction pathways. Among these, pathFinder is a unique tool that can find signal transduction pathways between first, second, or nth messengers and their targets within the cell. pathFinder can identify qualitatively all possible signal transduction pathways connecting any starting component and target within a database of two-component pathways (directional dyads). One or more intermediate pathway components can be excluded to simulate the use of pharmacological inhibitors or genetic deletion (knockout). Missing elements in a pathway connecting the activator or initiator and target can also be inferred from a null pathway result. The value of this static network analysis tool is illustrated by the predication from pathFinder analysis of a novel cyclic AMP-dependent, protein kinase A-independent signaling pathway in neuroendocrine cells, which has been experimentally confirmed. JF - Signal Transduction Knowledge Environment AU - Samal, Babru B AU - Eiden, Lee E AD - National Institute of Mental Health-Intramural Research Programs (NIMH-IRP) Bioinformatics Core, NIMH, NIH, Bethesda, MD 20892, USA. Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, 9000 Rockville Pike, Building 49, Room 5A-68, NIH, Bethesda, MD 20892, USA Y1 - 2008/08/05/ PY - 2008 DA - 2008 Aug 05 SP - pt4 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 1 IS - 31 SN - 1525-8882, 1525-8882 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Databases KW - Protein kinase KW - Signal transduction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20881001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Signal+Transduction+Knowledge+Environment&rft.atitle=pathFinder%3A+A+Static+Network+Analysis+Tool+for+Pharmacological+Analysis+of+Signal+Transduction+Pathways&rft.au=Samal%2C+Babru+B%3BEiden%2C+Lee+E&rft.aulast=Samal&rft.aufirst=Babru&rft.date=2008-08-05&rft.volume=1&rft.issue=31&rft.spage=pt4&rft.isbn=&rft.btitle=&rft.title=Signal+Transduction+Knowledge+Environment&rft.issn=15258882&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Databases; Protein kinase; Signal transduction ER - TY - JOUR T1 - A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda. AN - 69313818; 18585102 AB - Three of the four family X polymerases, DNA polymerase lambda, DNA polymerase mu, and TdT, have been associated with repair of double-strand DNA breaks by nonhomologous end-joining. Their involvement in this DNA repair process requires an N-terminal BRCT domain that mediates interaction with other protein factors required for recognition and binding of broken DNA ends. Here we present the NMR solution structure of the BRCT domain of DNA polymerase lambda, completing the structural portrait for this family of enzymes. Analysis of the overall fold of the polymerase lambda BRCT domain reveals structural similarity to the BRCT domains of polymerase mu and TdT, yet highlights some key sequence and structural differences that may account for important differences in the biological activities of these enzymes and their roles in nonhomologous end-joining. Mutagenesis studies indicate that the conserved Arg57 residue of Pol lambda plays a more critical role for binding to the XRCC4-Ligase IV complex than its structural homolog in Pol mu, Arg43. In contrast, the hydrophobic Leu60 residue of Pol lambda contributes less significantly to binding than the structurally homologous Phe46 residue of Pol mu. A third leucine residue involved in the binding and activity of Pol mu, is nonconservatively replaced by a glutamine in Pol lambda (Gln64) and, based on binding and activity data, is apparently unimportant for Pol lambda interactions with the NHEJ complex. In conclusion, both the structure of the Pol lambda BRCT domain and its mode of interaction with the other components of the NHEJ complex significantly differ from the two previously studied homologs, Pol mu and TdT. JF - DNA repair AU - Mueller, Geoffrey A AU - Moon, Andrea F AU - Derose, Eugene F AU - Havener, Jody M AU - Ramsden, Dale A AU - Pedersen, Lars C AU - London, Robert E AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, MD MR-01, Research Triangle Park, NC 27709, USA. mueller3@niehs.nih.gov Y1 - 2008/08/02/ PY - 2008 DA - 2008 Aug 02 SP - 1340 EP - 1351 VL - 7 IS - 8 SN - 1568-7864, 1568-7864 KW - DNA Primers KW - 0 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA polymerase beta2 KW - Index Medicus KW - Base Sequence KW - Models, Molecular KW - Nuclear Magnetic Resonance, Biomolecular KW - Electrophoretic Mobility Shift Assay KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Binding KW - Protein Conformation KW - Recombination, Genetic KW - DNA Polymerase beta -- chemistry KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69313818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=A+comparison+of+BRCT+domains+involved+in+nonhomologous+end-joining%3A+introducing+the+solution+structure+of+the+BRCT+domain+of+polymerase+lambda.&rft.au=Mueller%2C+Geoffrey+A%3BMoon%2C+Andrea+F%3BDerose%2C+Eugene+F%3BHavener%2C+Jody+M%3BRamsden%2C+Dale+A%3BPedersen%2C+Lars+C%3BLondon%2C+Robert+E&rft.aulast=Mueller&rft.aufirst=Geoffrey&rft.date=2008-08-02&rft.volume=7&rft.issue=8&rft.spage=1340&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2008.04.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-10 N1 - Date created - 2008-07-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 1992 Dec 21;314(3):413-8 [1281793] J Biomol NMR. 1991 Sep;1(3):217-36 [1841696] Biochemistry. 1994 May 17;33(19):5984-6003 [7514039] J Leukoc Biol. 1995 May;57(5):703-11 [7759949] FASEB J. 1997 Jan;11(1):68-76 [9034168] Structure. 1997 Jul 15;5(7):949-59 [9261088] J Biol Chem. 1998 Aug 14;273(33):21203-9 [9694877] Nat Struct Biol. 1998 Dec;5(12):1065-74 [9846877] J Biomol NMR. 1999 Mar;13(3):289-302 [10212987] Mol Cell. 2004 Dec 3;16(5):701-13 [15574326] J Biol Chem. 2005 May 6;280(18):18469-75 [15749700] Mol Cell. 2005 Aug 5;19(3):357-66 [16061182] Cell Cycle. 2005 Sep;4(9):1193-200 [16082219] Immunity. 2006 Jul;25(1):31-41 [16860755] Nat Struct Mol Biol. 2007 Jan;14(1):45-53 [17159995] Biochemistry. 2007 Oct 30;46(43):12100-10 [17915942] DNA Repair (Amst). 2007 Dec 1;6(12):1709-25 [17631059] FASEB J. 2000 Feb;14(2):231-41 [10657980] Mol Cell Biol. 2000 May;20(9):2996-3003 [10757784] J Am Chem Soc. 2001 Feb 7;123(5):967-75 [11456632] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2754-9 [11880627] J Biomol NMR. 2002 Jan;22(1):27-35 [11885978] J Mol Biol. 2002 May 24;319(1):209-27 [12051947] Mol Cell Biol. 2002 Jul;22(14):5194-202 [12077346] J Magn Reson. 2003 Jan;160(1):65-73 [12565051] Cell Biochem Biophys. 2003;37(3):187-211 [12625627] J Biol Chem. 2004 Jan 2;279(1):805-11 [14561766] Immunol Rev. 2004 Aug;200:5-11 [15242391] Immunol Rev. 2004 Aug;200:115-31 [15242400] Immunol Rev. 2004 Aug;200:156-64 [15242403] Biochem Biophys Res Commun. 2004 Oct 29;323(4):1328-33 [15451442] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] J Biomol NMR. 1993 Mar;3(2):225-31 [8477187] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2008.04.018 ER - TY - JOUR T1 - Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2 AN - 762279785; 13747428 AB - Individuals with mutations in breast cancer susceptibility genes BRCA1 and BRCA2 have up to an 80% risk of developing breast cancer by the age of 70. Sequencing-based genetic tests are now available to identify mutation carriers in an effort to reduce mortality through prevention and early diagnosis. However, lack of a suitable functional assay hinders the risk assessment of more than 1,900 BRCA1 and BRCA2 variants in the Breast Cancer Information Core database that do not clearly disrupt the gene product. We have established a simple, versatile and reliable assay to test for the functional significance of mutations in BRCA2 using mouse embryonic stem cells (ES cells) and bacterial artificial chromosomes and have used it to classify 17 sequence variants. The assay is based on the ability of human BRCA2 to complement the loss of endogenous Brca2 in mouse ES cells. This technique may also serve as a paradigm for functional analysis of mutations found in other genes linked to human diseases. JF - Nature Medicine AU - Kuznetsov, Sergey G AU - Liu, Pentao AU - Sharan, Shyam K AD - Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles Street, Frederick, Maryland 21702, USA. Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 875 EP - 881 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 14 IS - 8 SN - 1078-8956, 1078-8956 KW - Toxicology Abstracts; Genetics Abstracts KW - Risk assessment KW - Bacterial artificial chromosomes KW - Mortality KW - Databases KW - Stem cells KW - Age KW - Embryo cells KW - Breast cancer KW - BRCA1 protein KW - BRCA2 protein KW - Mutation KW - G 07770:Bacteria KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762279785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Mouse+embryonic+stem+cell-based+functional+assay+to+evaluate+mutations+in+BRCA2&rft.au=Kuznetsov%2C+Sergey+G%3BLiu%2C+Pentao%3BSharan%2C+Shyam+K&rft.aulast=Kuznetsov&rft.aufirst=Sergey&rft.date=2008-08-01&rft.volume=14&rft.issue=8&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm.1719 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Bacterial artificial chromosomes; Risk assessment; Databases; Mortality; Age; Stem cells; Embryo cells; BRCA1 protein; Breast cancer; BRCA2 protein; Mutation DO - http://dx.doi.org/10.1038/nm.1719 ER - TY - JOUR T1 - Optimizing radiotherapy of brain tumours by a combination of temozolomide & lonidamine. AN - 69779661; 19001677 AB - Temozolomide (TMZ), a second generation alkylating drug, an effective cytotoxic agent as well as radiosensitizer for malignant brain tumours, has side effects like myelosuppression. Lonidamine (LND) increases the effectiveness of several experimental multiple chemotherapy protocols, without increasing bone marrow toxicities and is effective in brain tumour patients. The objective of the present studies was to investigate whether combining clinically relevant doses of LND and TMZ could increase the proliferation and radiation response of malignant human brain tumour cells in vitro. A malignant human glioma (U373MG) cell line was used in these studies. TMZ (20, 40 or 60 microM) or LND (100, 150 or 200 microM), or the combination of both (20 and 100 microM, respectively) in 0.1 per cent dimethyl sulphoxide (DMSO) were added three days after setting up cultures, in six well plates (5 x 10(4) cells/ well). The effects of continuous treatment for two days on proliferation response and cytotoxicity were studied after trypsinization; by cell counts and the uptake of trypan blue dye (0.5%). For the study of radiation (60Co-Gamma-rays, 2 Gy) response, drugs were removed 4 h after irradiation and cultures were grown further in drug free, normal growth medium for another 20 h or 44 h. Continuous presence of TMZ or LND for two days significantly inhibited cell proliferation in a concentration dependent manner. The frequencies of non viable cells increased significantly only at higher concentrations of LND. Combination of 20 microM TMZ with 100 microM LND had additive effects on proliferation response, without affecting cell viability. Short-term drug treatments without irradiation did not induce micronuclei formation. Cell proliferation and viability were also not affected. However, post-irradiation presence of either of these drugs for 4 h significantly reduced the proliferation response, 24 and 48 h after treatments. It was further inhibited by the combination treatment. On the contrary, radiation induced micronuclei formation was enhanced by either of the drugs; which was significantly increased by the combined treatment, 24 h as well as 48 h after irradiation. No effects on cell viability were observed, immediately after these treatments as well as at later time points. Our findings showed that combination of TMZ and LND at clinically achievable, low plasma concentrations could inhibit tumour growth, and lonidamine could reduce the dose of temozolomide required for radiosensitization of brain tumours. JF - The Indian journal of medical research AU - Prabhakara, S AU - Kalia, V K AD - Department of Biophysics, National Institute of Mental Health & Neuro Sciences, Bangalore, India. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 140 EP - 148 VL - 128 IS - 2 SN - 0971-5916, 0971-5916 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Indazoles KW - Radiation-Sensitizing Agents KW - Dacarbazine KW - 7GR28W0FJI KW - Acridine Orange KW - F30N4O6XVV KW - lonidamine KW - U78804BIDR KW - temozolomide KW - YF1K15M17Y KW - Index Medicus KW - Analysis of Variance KW - Gamma Rays KW - Dacarbazine -- analogs & derivatives KW - Humans KW - Dacarbazine -- pharmacology KW - Indazoles -- pharmacology KW - Cell Line, Tumor KW - Cell Proliferation -- drug effects KW - Brain Neoplasms -- drug therapy KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Radiation-Sensitizing Agents -- pharmacology KW - Brain Neoplasms -- radiotherapy KW - Radiotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69779661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Indian+journal+of+medical+research&rft.atitle=Optimizing+radiotherapy+of+brain+tumours+by+a+combination+of+temozolomide+%26amp%3B+lonidamine.&rft.au=Prabhakara%2C+S%3BKalia%2C+V+K&rft.aulast=Prabhakara&rft.aufirst=S&rft.date=2008-08-01&rft.volume=128&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=The+Indian+journal+of+medical+research&rft.issn=09715916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2008-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incentive-elicited striatal activation in adolescent children of alcoholics. AN - 69658828; 18851716 AB - Deficient recruitment of motivational circuitry by non-drug rewards has been postulated as a pre-morbid risk factor for substance dependence (SD). We tested whether parental alcoholism, which confers risk of SD, is correlated with altered recruitment of ventral striatum (VS) by non-drug rewards in adolescence. During functional magnetic resonance imaging, adolescent children of alcoholics (COA; age 12-16 years) with no psychiatric disorders (including substance abuse) and similarly aged children with no risk factors responded to targets to win or avoid losing $0, $0.20, $1, $5 or a variable amount (ranging from $0.20 to $5). In general, brain activation by either reward anticipation or outcome notification did not differ between COA and age/gender-matched controls. Cue-elicited reward anticipation activated portions of VS in both COA and controls. In nucleus accumbens (NAcc), signal change increased with anticipated reward magnitude (with intermediate recruitment by variable incentives) but not with loss magnitudes. Reward deliveries activated the NAcc and mesofrontal cortex in both COA and controls. Losses activated anterior insula bilaterally in both groups, with more extensive right anterior insula activation by losses in controls. NAcc signal change during anticipation of maximum rewards (relative to non-reward) correlated positively with both Brief Sensation-Seeking Scale scores and with self-reported excitement in response to maximum reward cues (relative to cues for non-reward). Among adolescents with no psychiatric disorders, incentive-elicited VS activation may relate more to individual differences in sensation-seeking personality than to presence of parental alcoholism alone. Future research could focus on adolescents with behavior disorders or additional risk factors. JF - Addiction (Abingdon, England) AU - Bjork, James M AU - Knutson, Brian AU - Hommer, Daniel W AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. jbjork@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1308 EP - 1319 VL - 103 IS - 8 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Neural Pathways -- physiopathology KW - Analysis of Variance KW - Risk-Taking KW - Motivation KW - Humans KW - Child KW - Longitudinal Studies KW - Cerebral Cortex -- physiopathology KW - Cues KW - Adolescent KW - Female KW - Male KW - Brain Mapping KW - Nucleus Accumbens -- physiology KW - Child of Impaired Parents -- psychology KW - Behavior, Addictive -- psychology KW - Alcoholism -- psychology KW - Caudate Nucleus -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69658828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Incentive-elicited+striatal+activation+in+adolescent+children+of+alcoholics.&rft.au=Bjork%2C+James+M%3BKnutson%2C+Brian%3BHommer%2C+Daniel+W&rft.aulast=Bjork&rft.aufirst=James&rft.date=2008-08-01&rft.volume=103&rft.issue=8&rft.spage=1308&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02250.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-12 N1 - Date created - 2008-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02250.x ER - TY - JOUR T1 - Role of major NMDA or AMPA receptor subunits in MK-801 potentiation of ethanol intoxication. AN - 69529469; 18565157 AB - The glutamate system plays a major role in mediating EtOH's effects on brain and behavior, and is implicated in the pathophysiology of alcohol-related disorders. N-methyl-D-aspartate receptor (NMDAR) antagonists such as MK-801 (dizocilpine) interact with EtOH at the behavioral level, but the molecular basis of this interaction is unclear. We first characterized the effects of MK-801 treatment on responses to the ataxic (accelerating rotarod), hypothermic and sedative/hypnotic effects of acute EtOH administration in C57BL/6J and 129/SvImJ inbred mice. Effects of another NMDAR antagonist, phencyclidine, on EtOH-induced sedation/hypnosis were also assessed. Gene knockout of the NMDAR subunit NR2A or l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate GluR1 or pharmacological antagonism of the NMDAR subunit NR2B (via Ro 25-6981) was employed to examine whether inactivating any one of these glutamate signaling molecules modified MK-801's effect on EtOH-related behaviors. MK-801 markedly potentiated the ataxic effects of 1.75 g/kg EtOH and the sedative/hypnotic effects of 3.0 g/kg EtOH, but not the hypothermic effects of 3.0 g/kg EtOH, in C57BL/6J and 129/SvImJ mice. Phencyclidine potentiated EtOH-induced sedation/hypnosis in both inbred strains. Neither NR2A nor GluR1 KO significantly altered basal EtOH-induced ataxia, hypothermia, or sedation/hypnosis. Ro 25-6981 modestly increased EtOH-induced sedation/hypnosis. The ability of MK-801 to potentiate EtOH-induced ataxia and sedation/hypnosis was unaffected by GluR1 KO or NR2B antagonism. NR2A KO partially reduced MK-801 + EtOH-induced sedation/hypnosis, but not ataxia or hypothermia. Data confirm a robust and response-specific potentiating effect of MK-801 on sensitivity to EtOH's intoxicating effects. Inactivation of three major components of glutamate signaling had no or only partial impact on the ability of MK-801 to potentiate behavioral sensitivity to EtOH. Further work to elucidate the mechanisms underlying NMDAR x EtOH interactions could ultimately provide novel insight into the role of NMDARs in alcoholism and its treatment. JF - Alcoholism, clinical and experimental research AU - Palachick, Benjamin AU - Chen, Yi-Chyan AU - Enoch, Abigail J AU - Karlsson, Rose-Marie AU - Mishina, Masayoshi AU - Holmes, Andrew AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane Room 2N09, Rockville, MD 20852-9411, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1479 EP - 1492 VL - 32 IS - 8 KW - Central Nervous System Depressants KW - 0 KW - NR2A NMDA receptor KW - Neuroprotective Agents KW - Receptors, AMPA KW - Receptors, N-Methyl-D-Aspartate KW - glutamate receptor ionotropic, AMPA 1 KW - Ethanol KW - 3K9958V90M KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Phencyclidine KW - J1DOI7UV76 KW - Index Medicus KW - Animals KW - Ataxia -- chemically induced KW - Drug Interactions KW - Ethanol -- pharmacology KW - Phencyclidine -- pharmacology KW - Disease Models, Animal KW - Mice KW - Mice, Knockout KW - Immobility Response, Tonic -- physiology KW - Ataxia -- physiopathology KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- adverse effects KW - Central Nervous System Depressants -- adverse effects KW - Hypothermia -- physiopathology KW - Mice, Inbred C57BL KW - Hypothermia -- chemically induced KW - Male KW - Female KW - Immobility Response, Tonic -- drug effects KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Receptors, AMPA -- antagonists & inhibitors KW - Alcoholic Intoxication -- physiopathology KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Receptors, AMPA -- physiology KW - Receptors, AMPA -- genetics KW - Receptors, N-Methyl-D-Aspartate -- genetics KW - Neuroprotective Agents -- pharmacology KW - Dizocilpine Maleate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69529469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Role+of+major+NMDA+or+AMPA+receptor+subunits+in+MK-801+potentiation+of+ethanol+intoxication.&rft.au=Palachick%2C+Benjamin%3BChen%2C+Yi-Chyan%3BEnoch%2C+Abigail+J%3BKarlsson%2C+Rose-Marie%3BMishina%2C+Masayoshi%3BHolmes%2C+Andrew&rft.aulast=Palachick&rft.aufirst=Benjamin&rft.date=2008-08-01&rft.volume=32&rft.issue=8&rft.spage=1479&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/10.1111%2Fj.1530-0277.2008.00715.x LA - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1530-0277.2008.00715.x ER - TY - JOUR T1 - Seizures in HIV-seropositive individuals: NIMHANS experience and review. AN - 69477045; 18754959 AB - Seizures are not uncommon in patients with human immunodeficiency virus (HIV) infection, and with the upsurge in HIV infection this may be an important cause for acute symptomatic seizures. Seizures may rarely be the presenting manifestation of HIV infection. Opportunistic infections such as toxoplasmosis, tuberculosis, progressive multifocal leucoencephalopathy (PML), cryptococcal meningitis and polymicrobial infections, metabolic and electrolyte disturbances, and drugs are common causes of new-onset seizures in HIV-seropositive individuals. In the absence of any cause, primary HIV infection may be considered responsible for seizures. Because seizures tend to recur in and because they are a poor prognostic indicator in HIV infection, treatment with antiepileptic drugs (AEDs) is the norm. The treatment of HIV-infected individuals with seizures comprises of the administration of AEDs, specific treatment of the underlying conditions, and antiretroviral drugs. Clinicians must consider both therapy-compromising drug-drug and drug-disease interactions while choosing appropriate AEDs. The ideal AED in this setting is one that does not affect viral replication, have limited protein binding, and have no effects on the hepatic cytochrome P450 enzyme system. The risks for AED-induced allergic skin rash appears to be high in HIV-seropositive individuals. JF - Epilepsia AU - Satishchandra, P AU - Sinha, Sanjib AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. psatish@nimhans.kar.nic.in Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 33 EP - 41 VL - 49 Suppl 6 KW - Anticonvulsants KW - 0 KW - Index Medicus KW - Brain -- physiopathology KW - Opportunistic Infections -- epidemiology KW - India -- epidemiology KW - Drug Interactions KW - Humans KW - Electroencephalography KW - Tomography, X-Ray Computed KW - Incidence KW - Anticonvulsants -- therapeutic use KW - Brain -- diagnostic imaging KW - Catchment Area (Health) KW - Epilepsy -- physiopathology KW - Epilepsy -- diagnosis KW - HIV Infections -- epidemiology KW - Epilepsy -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69477045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=Seizures+in+HIV-seropositive+individuals%3A+NIMHANS+experience+and+review.&rft.au=Satishchandra%2C+P%3BSinha%2C+Sanjib&rft.aulast=Satishchandra&rft.aufirst=P&rft.date=2008-08-01&rft.volume=49+Suppl+6&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=1528-1167&rft_id=info:doi/10.1111%2Fj.1528-1167.2008.01754.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-26 N1 - Date created - 2008-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1528-1167.2008.01754.x ER - TY - JOUR T1 - Systematic investigation of polyamidoamine dendrimers surface-modified with poly(ethylene glycol) for drug delivery applications: synthesis, characterization, and evaluation of cytotoxicity. AN - 69451347; 18610944 AB - Surface modification of amine-terminated polyamidoamine (PAMAM) dendrimers by poly(ethylene glycol) (PEG) groups generally enhances water-solubility and biocompatibility for drug delivery applications. In order to provide guidelines for designing appropriate dendritic scaffolds, a series of G3 PAMAM-PEG dendrimer conjugates was synthesized by varying the number of PEG attachments and chain length (shorter PEG 550 and PEG 750 and longer PEG 2000). Each conjugate was purified by size exclusion chromatography (SEC) and the molecular weight (MW) was determined by (1)H NMR integration and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). NOESY experiments performed in D 2O on selected structures suggested no penetration of PEG chains to the central PAMAM domain, regardless of chain length and degree of substitution. CHO cell cultures exposed to PAMAM-PEG derivatives (< or =1 microM) showed a relatively high cell viability. Generally, increasing the degree of PEG substitution reduced cytotoxicity. Moreover, compared to G3 PAMAM dendrimers that were N-acetylated to varying degrees, a lower degree of surface substitution with PEG was needed for a similar cell viability. Interestingly, when longer PEG 2000 was fully incorporated on the surface, cell viability was reduced at higher concentrations (32 muM), suggesting increased toxicity potentially by forming intermolecular aggregates. A similar observation was made for anionic carboxylate G5.5 PAMAM dendrimer at the same dendrimer concentration. Our findings suggest that a lower degree of peripheral substitution with shorter PEG chains may suffice for these PAMAM-PEG conjugates to serve as efficient universal scaffolds for drug delivery, particularly valuable in relation to targeting or other ligand-receptor interactions. JF - Bioconjugate chemistry AU - Kim, Yoonkyung AU - Klutz, Athena M AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.kim_yoonkyung@yahoo.com Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1660 EP - 1672 VL - 19 IS - 8 KW - Dendrimers KW - 0 KW - Drug Carriers KW - PAMAM Starburst KW - Polyamines KW - Polyethylene Glycols KW - 30IQX730WE KW - Index Medicus KW - Animals KW - Acetylation KW - Cricetulus KW - Cell Survival -- drug effects KW - CHO Cells KW - Surface Properties KW - Cricetinae KW - Drug Carriers -- chemical synthesis KW - Polyethylene Glycols -- chemistry KW - Drug Carriers -- toxicity KW - Drug Carriers -- chemistry KW - Polyamines -- chemistry KW - Drug Carriers -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69451347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+chemistry&rft.atitle=Systematic+investigation+of+polyamidoamine+dendrimers+surface-modified+with+poly%28ethylene+glycol%29+for+drug+delivery+applications%3A+synthesis%2C+characterization%2C+and+evaluation+of+cytotoxicity.&rft.au=Kim%2C+Yoonkyung%3BKlutz%2C+Athena+M%3BJacobson%2C+Kenneth+A&rft.aulast=Kim&rft.aufirst=Yoonkyung&rft.date=2008-08-01&rft.volume=19&rft.issue=8&rft.spage=1660&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+chemistry&rft.issn=1520-4812&rft_id=info:doi/10.1021%2Fbc700483s LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Control Release. 2000 Mar 1;65(1-2):121-31 [10699276] Chemistry. 2004 Jun 7;10(11):2626-34 [15195294] Crit Rev Ther Drug Carrier Syst. 2000;17(2):101-61 [10820646] Bioconjug Chem. 2000 Nov-Dec;11(6):910-7 [11087341] J Am Chem Soc. 2002 May 15;124(19):5291-3 [11996569] Bioconjug Chem. 2002 May-Jun;13(3):453-61 [12009933] Curr Opin Chem Biol. 2002 Aug;6(4):466-71 [12133722] Pharm Res. 2002 Sep;19(9):1310-6 [12403067] J Am Chem Soc. 2002 Nov 27;124(47):14137-46 [12440912] Bioconjug Chem. 2003 Jan-Feb;14(1):158-67 [12526705] Chembiochem. 2004 Aug 6;5(8):1081-7 [15300831] J Am Chem Soc. 2004 Aug 18;126(32):10044-8 [15303879] J Am Chem Soc. 2004 Sep 29;126(38):11936-43 [15382929] Bioconjug Chem. 1993 Sep-Oct;4(5):372-9 [8274523] Bioconjug Chem. 1996 Nov-Dec;7(6):703-14 [8950489] Drug Discov Today. 2005 Jan 1;10(1):35-43 [15676297] Bioconjug Chem. 2005 Mar-Apr;16(2):361-8 [15769090] Mol Pharm. 2005 Mar-Apr;2(2):129-38 [15804187] J Med Chem. 2005 Jun 2;48(11):3729-35 [15916424] J Med Chem. 2005 Sep 22;48(19):5892-9 [16161993] Angew Chem Int Ed Engl. 2005 Oct 21;44(41):6704-8 [16173106] Nat Biotechnol. 2005 Dec;23(12):1517-26 [16333296] Adv Drug Deliv Rev. 2005 Dec 14;57(15):2215-37 [16297497] Adv Drug Deliv Rev. 2005 Dec 14;57(15):2106-29 [16305813] Adv Drug Deliv Rev. 2005 Dec 14;57(15):2147-62 [16310283] Pharm Res. 2005 Dec;22(12):2099-106 [16184444] Angew Chem Int Ed Engl. 2006 Feb 13;45(8):1198-215 [16444775] Analyst. 2006 Mar;131(3):374-81 [16496045] Pharmacol Rev. 2006 Mar;58(1):32-45 [16507881] J Phys Chem B. 2006 Mar 9;110(9):4014-9 [16509691] Chem Commun (Camb). 2006 Jun 14;(22):2362-4 [16733580] Drug Discov Today. 2006 Sep;11(17-18):812-8 [16935749] Biochem Pharmacol. 2006 Oct 16;72(8):1031-41 [16934758] Biochem Soc Trans. 2007 Feb;35(Pt 1):61-7 [17233602] FASEB J. 2007 Apr;21(4):1117-25 [17218540] Bioconjug Chem. 2007 May-Jun;18(3):663-70 [17375896] J Biomed Mater Res A. 2007 Jul;82(1):92-103 [17269145] Pharm Res. 2007 Aug;24(8):1405-14 [17393074] Bioconjug Chem. 2007 Jul-Aug;18(4):1163-9 [17569497] J Mater Sci Mater Med. 2007 Oct;18(10):2061-5 [17558476] Bioconjug Chem. 2007 Nov-Dec;18(6):2054-60 [17960872] Biomaterials. 2008 Apr;29(11):1664-75 [18194811] Bioconjug Chem. 2008 Feb;19(2):461-9 [18173227] Bioconjug Chem. 2008 Feb;19(2):406-11 [18176997] Angew Chem Int Ed Engl. 2002 Apr 15;41(8):1329-34 [19750755] Biomaterials. 2003 Mar;24(7):1121-31 [12527253] Int J Pharm. 2003 Feb 18;252(1-2):263-6 [12550802] Nat Rev Drug Discov. 2003 Mar;2(3):214-21 [12612647] Nature. 2003 Mar 6;422(6927):37-44 [12621426] Nat Rev Drug Discov. 2003 May;2(5):347-60 [12750738] Pharm Res. 2003 Oct;20(10):1543-50 [14620505] Bioconjug Chem. 2003 Nov-Dec;14(6):1214-21 [14624638] J Biomater Sci Polym Ed. 2003;14(10):1043-56 [14661878] J Am Chem Soc. 2003 Dec 17;125(50):15485-9 [14664594] Chem Soc Rev. 2004 Jan 10;33(1):43-63 [14737508] J Colloid Interface Sci. 2004 May 1;273(1):148-54 [15051444] J Control Release. 2000 Mar 1;65(1-2):133-48 [10699277] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bc700483s ER - TY - JOUR T1 - Food microbial pathogen detection and analysis using DNA microarray technologies. AN - 69444966; 18673074 AB - Culture-based methods used for microbial detection and identification are simple to use, relatively inexpensive, and sensitive. However, culture-based methods are too time-consuming for high-throughput testing and too tedious for analysis of samples with multiple organisms and provide little clinical information regarding the pathogen (e.g., antibiotic resistance genes, virulence factors, or strain subtype). DNA-based methods, such as polymerase chain reaction (PCR), overcome some these limitations since they are generally faster and can provide more information than culture-based methods. One limitation of traditional PCR-based methods is that they are normally limited to the analysis of a single pathogen, a small group of related pathogens, or a small number of relevant genes. Microarray technology enables a significant expansion of the capability of DNA-based methods in terms of the number of DNA sequences that can be analyzed simultaneously, enabling molecular identification and characterization of multiple pathogens and many genes in a single array assay. Microarray analysis of microbial pathogens has potential uses in research, food safety, medical, agricultural, regulatory, public health, and industrial settings. In this article, we describe the main technical elements of microarray technology and the application and potential use of DNA microarrays for food microbial analysis. JF - Foodborne pathogens and disease AU - Rasooly, Avraham AU - Herold, Keith E AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland, USA. rasoolya@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 531 EP - 550 VL - 5 IS - 4 KW - DNA Probes KW - 0 KW - DNA, Bacterial KW - RNA, Bacterial KW - RNA, Ribosomal KW - Virulence Factors KW - Index Medicus KW - Sensitivity and Specificity KW - Genotype KW - Gene Expression Profiling KW - DNA, Bacterial -- genetics KW - Polymerase Chain Reaction -- methods KW - Drug Resistance, Bacterial -- genetics KW - RNA, Ribosomal -- genetics KW - Virulence Factors -- genetics KW - RNA, Bacterial -- genetics KW - Microspheres KW - Bacteria -- genetics KW - Food Microbiology KW - Oligonucleotide Array Sequence Analysis -- methods KW - Bacteria -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69444966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Foodborne+pathogens+and+disease&rft.atitle=Food+microbial+pathogen+detection+and+analysis+using+DNA+microarray+technologies.&rft.au=Rasooly%2C+Avraham%3BHerold%2C+Keith+E&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2008-08-01&rft.volume=5&rft.issue=4&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Foodborne+pathogens+and+disease&rft.issn=1556-7125&rft_id=info:doi/10.1089%2Ffpd.2008.0119 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-23 N1 - Date created - 2008-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Microbiol Methods. 2005 Mar;60(3):291-8 [15649531] Appl Environ Microbiol. 2005 Mar;71(3):1373-86 [15746340] Mol Cell Probes. 2005 Jun;19(3):195-201 [15797820] Surg Today. 2005;35(5):396-403 [15864422] J Clin Microbiol. 2005 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Environ Microbiol. 2004 Jul;70(7):4256-66 [15240309] Diagn Microbiol Infect Dis. 2004 Jul;49(3):163-71 [15246505] J Mol Microbiol Biotechnol. 2008;14(1-3):6-15 [17957105] J Clin Microbiol. 2007 Nov;45(11):3514-21 [17728472] Jpn J Infect Dis. 2007 Nov;60(6):355-61 [18032834] Anal Chem. 2007 Dec 1;79(23):9007-13 [17949012] Microb Drug Resist. 2007 Winter;13(4):281-8 [18184054] Biomacromolecules. 2008 Jan;9(1):355-62 [18052028] Microbiology. 2008 Feb;154(Pt 2):462-75 [18227250] Mol Cell Probes. 2003 Aug;17(4):187-96 [12944122] J Clin Microbiol. 2003 Sep;41(9):4071-80 [12958228] J Appl Microbiol. 2003;95(4):787-98 [12969293] Antimicrob Agents Chemother. 2003 Oct;47(10):3290-5 [14506043] Biotechniques. 2003 Dec;35(6):1216-21 [14682056] J Mol Diagn. 2004 Aug;6(3):236-42 [15269301] Biotechniques. 2004 Jul;37(1):40, 42, 44 [15283198] J Antimicrob Chemother. 2004 Aug;54(2):376-85 [15201233] J Clin Microbiol. 2004 Aug;42(8):3766-74 [15297528] Annu Rev Microbiol. 1986;40:337-65 [2430518] FEMS Microbiol Rev. 1994 Oct;15(2-3):155-73 [7524576] Nucleic Acids Res. 1996 Aug 1;24(15):3040-7 [8760891] Appl Environ Microbiol. 1997 Jun;63(6):2397-402 [9172361] Anal Biochem. 1997 Aug 1;250(2):203-11 [9245440] Anal Biochem. 1997 Sep 5;251(2):270-9 [9299026] J Mol Evol. 1998 Jun;46(6):716-20 [9608054] J Mol Evol. 1998 Nov;47(5):565-77 [9797407] Anal Biochem. 1999 Jan 1;266(1):23-30 [9887210] Nucleic Acids Res. 1999 May 1;27(9):1970-7 [10198429] Cancer Res. 2004 Nov 1;64(21):7664-7 [15520165] Biosens Bioelectron. 2004 Nov 1;20(4):684-98 [15522583] FEMS Microbiol Lett. 2004 Nov 15;240(2):215-23 [15522510] Appl Environ Microbiol. 2004 Dec;70(12):7436-44 [15574946] FEMS Microbiol Lett. 2005 Jan 1;242(1):65-71 [15621421] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/fpd.2008.0119 ER - TY - JOUR T1 - Measurement of sex steroid hormones in breast adipocytes: methods and implications. AN - 69434142; 18708377 AB - The lack of validated methods for measuring sex steroid hormones in breast tissue has limited our knowledge of their role in the development of breast cancer. We explored the feasibility of measuring hormones in breast adipocytes for epidemiologic and clinical studies by refining an existing assay procedure and assessing the reliability of hormone measurements using the modified assay. This report presents the reproducibility of measurements of androstenedione (A), testosterone (T), estrone (E(1)), and estradiol (E(2)), using breast adipose tissue samples obtained from women undergoing surgical resection for a variety of pathologic conditions. Breast adipose tissues were obtained from 20 women. Measurements of the steroid hormones were carried out by harvesting oil from adipocytes following enzymatic digestion of the adipose tissue, extracting and chromatographing the steroids, and quantifying them by RIA. The study was conducted in three phases: first, samples from five women were used to assess the assay procedure; following this, tissues from an additional five women were assayed repeatedly to determine reproducibility of the hormone measurements. Finally, using samples from 10 women undergoing surgical resection of a breast tumor, we evaluated hormone concentrations in samples distal and proximal to the tumor. The assay coefficient of variation and intraclass correlation coefficient were used to assess hormone reproducibility. The within-batch coefficients of variation ranged from 5% to 17%, and between-batch estimates were between 2% and 10%, suggesting that E(1), E(2), A, and T can be reliably measured in breast adipocytes. Among samples obtained from women undergoing surgical resection of a breast tumor, hormone levels did not differ between adipose tissue fragments that were distal or proximal to the tumor, with the possible exception of E(1) in which levels were 10% higher in distal fragments. These data support the feasibility of measuring steroid hormone concentrations in breast adipocytes in epidemiologic studies. Future investigations that include the measurement of hormones in the breast microenvironment may have value in understanding breast carcinogenesis, developing prevention strategies, and assessing hormonal treatments. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Falk, Roni T AU - Gentzschein, Elisabet AU - Stanczyk, Frank Z AU - Brinton, Louise A AU - Garcia-Closas, Montserrat AU - Ioffe, Olga B AU - Sherman, Mark E AD - Division of Cancer Epidemiology and Genetics, Epidemiology and Biostatistics Program, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard S, Bethesda, MD 20892, USA. falkr@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1891 EP - 1895 VL - 17 IS - 8 SN - 1055-9965, 1055-9965 KW - Gonadal Steroid Hormones KW - 0 KW - Index Medicus KW - Feasibility Studies KW - Analysis of Variance KW - Reproducibility of Results KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Radioimmunoassay KW - Female KW - Breast -- cytology KW - Gonadal Steroid Hormones -- metabolism KW - Breast Neoplasms -- metabolism KW - Adipocytes -- metabolism KW - Breast -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69434142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Measurement+of+sex+steroid+hormones+in+breast+adipocytes%3A+methods+and+implications.&rft.au=Falk%2C+Roni+T%3BGentzschein%2C+Elisabet%3BStanczyk%2C+Frank+Z%3BBrinton%2C+Louise+A%3BGarcia-Closas%2C+Montserrat%3BIoffe%2C+Olga+B%3BSherman%2C+Mark+E&rft.aulast=Falk&rft.aufirst=Roni&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=1891&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0119 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-16 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocr Relat Cancer. 1999 Jun;6(2):165-73 [10731105] Endocr Relat Cancer. 2005 Dec;12(4):701-20 [16322318] J Natl Cancer Inst. 2002 Apr 17;94(8):606-16 [11959894] J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):245-53 [14623518] J Clin Endocrinol Metab. 1973 May;36(5):867-79 [4349047] Am J Obstet Gynecol. 1974 Jun 15;119(4):445-52 [4842588] Cancer Res. 1985 Jun;45(6):2900-6 [3986816] Eur J Cancer Clin Oncol. 1986 Apr;22(4):515-25 [3015631] Int J Cancer. 1991 Oct 21;49(4):562-5 [1917157] J Steroid Biochem Mol Biol. 1992 Mar;41(3-8):891-6 [1314086] J Clin Endocrinol Metab. 1992 Jun;74(6):1247-52 [1592866] J Clin Endocrinol Metab. 1992 Jul;75(1):195-200 [1619010] J Clin Endocrinol Metab. 1993 Oct;77(4):1041-5 [8408452] J Clin Endocrinol Metab. 1996 Apr;81(4):1460-4 [8636351] Anal Quant Cytol Histol. 1996 Apr;18(2):137-43 [8744503] Cancer Epidemiol Biomarkers Prev. 1996 Oct;5(10):835-44 [8896895] Int J Cancer. 1997 Mar 17;70(6):639-43 [9096642] Obstet Gynecol. 1997 Aug;90(2):244-8 [9241302] Steroids. 1998 May-Jun;63(5-6):319-21 [9618794] J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):293-7 [10419005] J Biol Chem. 1964 Feb;239:375-80 [14169133] Menopause. 2005 Mar;12(2):210-5 [15772569] J Steroid Biochem Mol Biol. 2005 Feb;93(2-5):221-36 [15860265] J Steroid Biochem Mol Biol. 2000 Jan-Feb;72(1-2):23-7 [10731634] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0119 ER - TY - JOUR T1 - Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists. AN - 69433269; 18708391 AB - Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Bhatti, Parveen AU - Doody, Michele M AU - Alexander, Bruce H AU - Yuenger, Jeff AU - Simon, Steven L AU - Weinstock, Robert M AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Abend, Michael AU - Preston, Dale L AU - Pharoah, Paul AU - Struewing, Jeffery P AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892-7238, USA. bhattip@mail.NIH.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 2007 EP - 2011 VL - 17 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - United States KW - Genotype KW - Humans KW - Chi-Square Distribution KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Likelihood Functions KW - Male KW - Female KW - Breast Neoplasms -- genetics KW - Polymorphism, Single Nucleotide KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- etiology KW - Occupational Exposure -- adverse effects KW - Neoplasms, Radiation-Induced -- mortality KW - Neoplasms, Radiation-Induced -- genetics KW - Radiation, Ionizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69433269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Breast+cancer+risk+polymorphisms+and+interaction+with+ionizing+radiation+among+U.S.+radiologic+technologists.&rft.au=Bhatti%2C+Parveen%3BDoody%2C+Michele+M%3BAlexander%2C+Bruce+H%3BYuenger%2C+Jeff%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BAbend%2C+Michael%3BPreston%2C+Dale+L%3BPharoah%2C+Paul%3BStruewing%2C+Jeffery+P%3BSigurdson%2C+Alice+J&rft.aulast=Bhatti&rft.aufirst=Parveen&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=2007&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0300 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-16 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Cytogenet Genome Res. 2006;113(1-4):188-93 [16575179] Radiat Res. 2007 Jun;167(6):727-34 [17523852] Nature. 2007 Jun 28;447(7148):1087-93 [17529967] Nat Genet. 2007 Aug;39(8):954-6 [17618282] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2000-7 [17932347] Int J Cancer. 2008 Jan 1;122(1):177-82 [17764108] Endocr Relat Cancer. 2001 Sep;8(3):197-209 [11566611] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Oncogene. 2003 Sep 1;22(37):5848-54 [12947391] Mol Carcinog. 2004 Sep;41(1):1-16 [15352122] J Chronic Dis. 1987;40 Suppl 2:45S-57S [3312274] JAMA. 1991 Mar 13;265(10):1290-4 [2053936] Breast Cancer Res. 2005;7(1):21-32 [15642178] Biochem Biophys Res Commun. 2006 Feb 3;340(1):83-9 [16359639] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0300 ER - TY - JOUR T1 - Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. AN - 69431595; 18566013 AB - This study investigated associations between occupational pesticide exposure and renal cell carcinoma (RCC) risk. To follow-up on a previous report by Buzio et al., we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes. About 1097 RCC cases and 1476 controls from Central and Eastern Europe were interviewed to collect data on lifetime occupational histories. Occupational information for jobs held for at least 12 months duration was coded for pesticide exposures and assessed for frequency and intensity of exposure. GSTM1 and GSTT1 gene deletions were analyzed using TaqMan assays. A significant increase in RCC risk was observed among subjects ever exposed to pesticides [odds ratio (OR): 1.60; 95% confidence interval (CI): 1.00-2.55]. After stratification by genotypes, increased risk was observed among exposed subjects with at least one GSTM1 active allele (OR: 4.00; 95% CI: 1.55-10.33) but not among exposed subjects with two GSTM1 inactive alleles compared with unexposed subjects with two inactive alleles (P-interaction: 0.04). Risk was highest among exposed subjects with both GSTM1 and GSTT1 active genotypes (OR: 6.47; 95% CI: 1.82-23.00; P-interaction: 0.02) compared with unexposed subjects with at least one GSTM1 or T1 inactive genotype. In the largest RCC case-control study with genotype information conducted to date, we observed that risk associated with pesticide exposure was exclusive to individuals with active GSTM1/T1 genotypes. These findings further support the hypothesis that glutathione S-transferase polymorphisms can modify RCC risk associated with occupational pesticide exposure. JF - Carcinogenesis AU - Karami, S AU - Boffetta, P AU - Rothman, N AU - Hung, R J AU - Stewart, T AU - Zaridze, D AU - Navritalova, M AU - Mates, D AU - Janout, V AU - Kollarova, H AU - Bencko, V AU - Szeszenia-Dabrowska, N AU - Holcatova, I AU - Mukeria, A AU - Gromiec, J AU - Chanock, S J AU - Brennan, P AU - Chow, W-H AU - Moore, L E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. karamis@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1567 EP - 1571 VL - 29 IS - 8 KW - Pesticides KW - 0 KW - GSTT2 protein, human KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Occupational Exposure KW - Humans KW - Aged KW - Europe -- epidemiology KW - Risk Assessment KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Interviews as Topic KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Kidney Neoplasms -- genetics KW - Carcinoma, Renal Cell -- enzymology KW - Carcinoma, Renal Cell -- classification KW - Polymorphism, Genetic KW - Kidney Neoplasms -- enzymology KW - Kidney Neoplasms -- chemically induced KW - Kidney Neoplasms -- epidemiology KW - Glutathione Transferase -- genetics KW - Carcinoma, Renal Cell -- genetics KW - Pesticides -- toxicity KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69431595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Renal+cell+carcinoma%2C+occupational+pesticide+exposure+and+modification+by+glutathione+S-transferase+polymorphisms.&rft.au=Karami%2C+S%3BBoffetta%2C+P%3BRothman%2C+N%3BHung%2C+R+J%3BStewart%2C+T%3BZaridze%2C+D%3BNavritalova%2C+M%3BMates%2C+D%3BJanout%2C+V%3BKollarova%2C+H%3BBencko%2C+V%3BSzeszenia-Dabrowska%2C+N%3BHolcatova%2C+I%3BMukeria%2C+A%3BGromiec%2C+J%3BChanock%2C+S+J%3BBrennan%2C+P%3BChow%2C+W-H%3BMoore%2C+L+E&rft.aulast=Karami&rft.aufirst=S&rft.date=2008-08-01&rft.volume=29&rft.issue=8&rft.spage=1567&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-04 N1 - Date created - 2008-08-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):449-54 [10794492] Am J Epidemiol. 2008 Apr 1;167(7):759-74 [18270371] Pharmacogenetics. 2001 Aug;11(6):521-35 [11505222] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1239-48 [11751440] Occup Med (Lond). 2002 May;52(3):157-64 [12063361] Med Lav. 2002 Jul-Aug;93(4):303-9 [12212398] Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):885-9 [12223433] Epidemiology. 2003 Sep;14(5):585-92 [14501274] Occup Environ Med. 2003 Oct;60(10):789-93 [14504370] Chem Biol Interact. 1986 Oct 15;60(1):31-45 [3536138] Toxicol Appl Pharmacol. 1991 Jan;107(1):54-62 [1987660] Scand J Work Environ Health. 1994 Jun;20(3):160-5 [7973487] Int J Cancer. 1995 May 29;61(5):601-5 [7768630] Int J Epidemiol. 1995 Feb;24(1):51-7 [7797356] Arch Toxicol. 1997;71(9):596-9 [9285043] Am J Epidemiol. 1998 Sep 1;148(5):424-30 [9737554] Cancer Res. 1999 Jun 15;59(12):2903-8 [10383153] Int J Cancer. 2005 Mar 10;114(1):101-8 [15523697] Rev Environ Health. 2005 Apr-Jun;20(2):103-18 [16121833] Int J Cancer. 2006 May 15;118(10):2543-7 [16353144] Am J Epidemiol. 2006 Dec 1;164(11):1027-42 [17000715] Carcinogenesis. 2007 Sep;28(9):1960-4 [17617661] Chem Biol Interact. 2000 Dec 1;129(1-2):61-76 [11154735] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn153 ER - TY - JOUR T1 - Regulation of hypoxia-inducible genes by ETS1 transcription factor. AN - 69429618; 18381358 AB - Hypoxia-inducible factor (HIF-1) regulates the expression of genes that facilitate tumor cell survival by making them more resistant to therapeutic intervention. Recent evidence suggests that the activation of other transcription factors, in cooperation with HIF-1 or acting alone, is involved in the upregulation of hypoxia-inducible genes. Here we report that high cell density, a condition that might mimic the physiologic situation in growing tumor and most probably representing nutritional starvation, upregulates hypoxia-inducible genes. This upregulation can occur in HIF-independent manner since hypoxia-inducible genes carbonic anhydrase 9 (CA9), lysyloxidase like 2 (LOXL2) and n-myc-down regulated 1 (NDRG1)/calcium activated protein (Cap43) can be upregulated by increased cell density under both normoxic and hypoxic conditions in both HIF-1 alpha-proficient and -deficient mouse fibroblasts. Moreover, cell density upregulates the same genes in 1HAEo- and A549 human lung epithelial cells. Searching for other transcription factors involved in the regulation of hypoxia-inducible genes by cell density, we focused our attention on ETS1. As reported previously, members of v-ets erythroblastosis virus E26 oncogene homolog (ETS) family transcription factors participate in the upregulation of hypoxia-inducible genes. Here, we provide evidence that ETS1 protein is upregulated at high cell density in both human and mouse cells. The involvement of ETS1 in the upregulation of hypoxia-inducible genes was further confirmed in a luciferase reporter assay using cotransfection of ETS1 expression vector with NDRG1/Cap43 promoter construct. The downregulation of ETS1 expression with small interfering RNA (siRNA) inhibited the upregulation of CA9 and NDRG1/Cap43 caused by increased cell density. Collectively, our data indicate the involvement of ETS1 along with HIF-1 in regulating hypoxia-inducible genes. JF - Carcinogenesis AU - Salnikow, Konstantin AU - Aprelikova, Olga AU - Ivanov, Sergey AU - Tackett, Sean AU - Kaczmarek, Monika AU - Karaczyn, Aldona AU - Yee, Herman AU - Kasprzak, Kazimierz S AU - Niederhuber, John AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. salnikow@ncifcrf.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1493 EP - 1499 VL - 29 IS - 8 KW - ARNT protein, human KW - 0 KW - Antigens, Neoplasm KW - Cell Cycle Proteins KW - ETS1 protein, human KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Intracellular Signaling Peptides and Proteins KW - N-myc downstream-regulated gene 1 protein KW - Proto-Oncogene Protein c-ets-1 KW - RNA, Neoplasm KW - RNA, Small Interfering KW - Transcription Factors KW - Aryl Hydrocarbon Receptor Nuclear Translocator KW - 138391-32-9 KW - CA9 protein, human KW - EC 4.2.1.1 KW - Carbonic Anhydrase IX KW - Carbonic Anhydrases KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Transcription, Genetic KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - RNA, Neoplasm -- genetics KW - Lung -- physiology KW - Polymerase Chain Reaction KW - Gene Expression Profiling KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Cell Cycle Proteins -- genetics KW - Genes, Reporter KW - Lung Neoplasms -- genetics KW - Up-Regulation KW - Antigens, Neoplasm -- genetics KW - Lung Neoplasms -- physiopathology KW - Carbonic Anhydrases -- genetics KW - Gene Expression Regulation, Neoplastic KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Transcription Factors -- metabolism KW - Aryl Hydrocarbon Receptor Nuclear Translocator -- genetics KW - Proto-Oncogene Protein c-ets-1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69429618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Regulation+of+hypoxia-inducible+genes+by+ETS1+transcription+factor.&rft.au=Salnikow%2C+Konstantin%3BAprelikova%2C+Olga%3BIvanov%2C+Sergey%3BTackett%2C+Sean%3BKaczmarek%2C+Monika%3BKaraczyn%2C+Aldona%3BYee%2C+Herman%3BKasprzak%2C+Kazimierz+S%3BNiederhuber%2C+John&rft.aulast=Salnikow&rft.aufirst=Konstantin&rft.date=2008-08-01&rft.volume=29&rft.issue=8&rft.spage=1493&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn088 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-04 N1 - Date created - 2008-08-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur Respir J. 1999 Oct;14(4):806-11 [10573225] Lung Cancer. 2005 Sep;49(3):325-35 [15935515] J Biol Chem. 2000 Jan 21;275(3):1708-14 [10636866] Cancer Res. 2000 Jan 1;60(1):38-41 [10646848] Cancer Res. 2000 Dec 15;60(24):7075-83 [11156414] Am J Pathol. 2001 Mar;158(3):905-19 [11238039] Clin Cancer Res. 2005 Oct 15;11(20):7220-5 [16243791] Expert Opin Ther Targets. 2006 Apr;10(2):267-80 [16548775] J Cell Biochem. 2006 Apr 1;97(5):1025-35 [16288478] Nature. 2006 Apr 27;440(7088):1222-6 [16642001] Cancer Res. 2006 Jun 1;66(11):5641-7 [16740701] Cancer. 2006 Aug 15;107(4):757-66 [16826581] Trends Pharmacol Sci. 2006 Nov;27(11):566-73 [16996620] Mod Pathol. 2007 Jan;20(1):76-83 [17170744] Carcinogenesis. 2008 Jan;29(1):2-8 [17916902] Cancer Res. 2001 Jul 1;61(13):5262-7 [11431368] Cancer Res. 2001 Sep 1;61(17):6394-9 [11522632] Mol Cell Biol. 2002 Mar;22(6):1734-41 [11865053] Cell Biol Toxicol. 2002;18(2):87-96 [12046693] Cancer Res. 2002 Aug 1;62(15):4469-77 [12154057] Clin Cancer Res. 2002 Aug;8(8):2595-604 [12171890] J Mol Med (Berl). 2002 Sep;80(9):562-75 [12226738] Environ Health Perspect. 2002 Oct;110 Suppl 5:783-8 [12429530] J Biol Chem. 2003 Feb 28;278(9):7520-30 [12464608] Cancer Res. 2003 Mar 1;63(5):917-22 [12615703] Mol Cell Biol. 2003 Jul;23(14):4959-71 [12832481] Nat Rev Cancer. 2003 Oct;3(10):721-32 [13130303] Cell Cycle. 2004 Feb;3(2):164-7 [14712082] Circulation. 2004 Jun 22;109(24):3035-41 [15173033] Mol Cancer. 2003 Aug 20;2:29 [12971829] J Biol Chem. 2004 Sep 24;279(39):40337-44 [15271983] Genes Dev. 1992 Jun;6(6):975-90 [1592264] Oncogene. 1994 Oct;9(10):2877-88 [8084592] Am J Physiol. 1995 Mar;268(3 Pt 1):L347-60 [7900815] J Cell Physiol. 1996 Dec;169(3):522-31 [8952701] Cancer Res. 1997 Jun 15;57(12):2362-5 [9192809] Cancer Res. 1998 May 15;58(10):2182-9 [9605764] Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12596-601 [9770531] Carcinogenesis. 1999 Sep;20(9):1819-23 [10469629] Transfus Clin Biol. 2005 Feb;12(1):5-10 [15814285] Biochem Pharmacol. 2000 Jan 1;59(1):47-53 [10605934] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn088 ER - TY - JOUR T1 - N-arachidonoyl L-serine, a putative endocannabinoid, alters the activation of N-type Ca2+ channels in sympathetic neurons. AN - 69418714; 18234973 AB - The effect of N-arachidonoyl l-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca2+ channels of rat sympathetic ganglion neurons was determined using whole cell patch clamp. Application of ARA-S produced a rapid and reversible augmentation of Ca2+ current that was voltage dependent and resulted from a hyperpolarizing shift in the activation curve. ARA-S did not influence G protein modulation of Ca2+ channels and appeared to act independently of G-protein-coupled receptors. These findings provide a foundation for investigating possible roles for ARA-S in nervous system function. JF - Journal of neurophysiology AU - Guo, Juan AU - Williams, Damian J AU - Ikeda, Stephen R AD - Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, 5625 Fishers Ln., MSC 9411, Bethesda, MD 20892-9411, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1147 EP - 1151 VL - 100 IS - 2 SN - 0022-3077, 0022-3077 KW - Arachidonic Acids KW - 0 KW - Calcium Channels, N-Type KW - Cannabinoid Receptor Modulators KW - Endocannabinoids KW - GABA Antagonists KW - N-arachidonoyl L-serine KW - Picrotoxin KW - 124-87-8 KW - Serine KW - 452VLY9402 KW - Calcium KW - SY7Q814VUP KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Rats KW - Calcium -- metabolism KW - Animals KW - Electric Stimulation -- methods KW - Drug Interactions KW - Patch-Clamp Techniques KW - Norepinephrine -- pharmacology KW - Dose-Response Relationship, Drug KW - Picrotoxin -- pharmacology KW - Rats, Wistar KW - GABA Antagonists -- pharmacology KW - Male KW - Ion Channel Gating -- drug effects KW - Serine -- analogs & derivatives KW - Serine -- pharmacology KW - Cannabinoid Receptor Modulators -- pharmacology KW - Action Potentials -- physiology KW - Calcium Channels, N-Type -- physiology KW - Superior Cervical Ganglion -- cytology KW - Neurons -- drug effects KW - Neurons -- physiology KW - Action Potentials -- drug effects KW - Arachidonic Acids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69418714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=N-arachidonoyl+L-serine%2C+a+putative+endocannabinoid%2C+alters+the+activation+of+N-type+Ca2%2B+channels+in+sympathetic+neurons.&rft.au=Guo%2C+Juan%3BWilliams%2C+Damian+J%3BIkeda%2C+Stephen+R&rft.aulast=Guo&rft.aufirst=Juan&rft.date=2008-08-01&rft.volume=100&rft.issue=2&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/10.1152%2Fjn.01204.2007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-05 N1 - Date created - 2008-08-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Rev. 2006 Sep;58(3):389-462 [16968947] Pharmacol Ther. 2006 Jul;111(1):114-44 [16584786] J Pharmacol Exp Ther. 2008 Jan;324(1):342-51 [17940199] Mol Pharmacol. 2008 Feb;73(2):441-50 [17965195] Br J Pharmacol. 2000 Jan;129(2):227-30 [10694225] Am J Physiol Cell Physiol. 2001 May;280(5):C1293-305 [11287343] Am J Physiol Cell Physiol. 2001 May;280(5):C1306-18 [11287344] J Biol Chem. 2001 Nov 16;276(46):42639-44 [11518719] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8400-5 [12060783] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):295-300 [12496347] Mol Pharmacol. 2004 Mar;65(3):665-74 [14978245] Methods Mol Biol. 2004;259:167-81 [15250492] Nature. 1989 Jul 13;340(6229):153-6 [2567963] Eur J Pharmacol. 1990 May 3;180(1):37-47 [1973113] Neuron. 1990 Jul;5(1):75-80 [2164405] J Physiol. 1991 Aug;439:181-214 [1654413] Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6452-6 [1321440] Nature. 1996 Mar 21;380(6571):255-8 [8637575] Br J Pharmacol. 2005 Feb;144(4):459-65 [15655504] Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):111-22 [16099396] EMBO J. 2005 Sep 7;24(17):3026-37 [16107881] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2428-33 [16467152] Curr Opin Neurobiol. 2007 Jun;17(3):352-9 [17466513] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/jn.01204.2007 ER - TY - JOUR T1 - Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. AN - 69418014; 18497350 AB - Endocannabinoids released from the postsynaptic neuronal membrane can activate presynaptic CB1 receptors and inhibit neurotransmitter release. In hippocampal slices, depolarization of the CA1 pyramidal neurons elicits an endocannabinoid-mediated inhibition of gamma-aminobutyric acid release known as depolarization-induced suppression of inhibition (DSI). Using the highly reduced neuron/synaptic bouton preparation from the CA1 region of hippocampus, we have begun to examine endocannabinoid-dependent short-term depression (STD) of inhibitory synaptic transmission under well-controlled physiological and pharmacological conditions in an environment free of other cells. Application of the CB1 synthetic agonist WIN55212-2 and endogenous cannabinoids 2-AG and anandamide produced a decrease in spontaneous inhibitory postsynaptic current (sIPSC) frequency and amplitude, indicating the presence of CB1 receptors at synapses in this preparation. Endocannabinoid-dependent STD is different from DSI found in hippocampal slices and the neuron/bouton preparation from basolateral amygdala (BLA) since depolarization alone was not sufficient to induce suppression of sIPSCs. However, concurrent application of the metabotropic glutamate receptor (mGluR) agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) and postsynaptic depolarization resulted in a transient (30-50 s) decrease in sIPSC frequency and amplitude. Application of DHPG alone had no effect on sIPSCs. The depolarization/DHPG-induced STD was blocked by the CB1 antagonist SR141716A and the mGluR5 antagonist MPEP and was sensitive to intracellular calcium concentration. Comparing the present findings with earlier work in hippocampal slices and BLA, it appears that endocannabinoid release is less robust in isolated hippocampal neurons. JF - Journal of neurophysiology AU - Sheinin, Anton AU - Talani, Giuseppe AU - Davis, Margaret I AU - Lovinger, David M AD - Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20892-8115, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1041 EP - 1052 VL - 100 IS - 2 SN - 0022-3077, 0022-3077 KW - Arachidonic Acids KW - 0 KW - Benzoxazines KW - Cannabinoid Receptor Modulators KW - Endocannabinoids KW - Excitatory Amino Acid Antagonists KW - Glycerides KW - Grm5 protein, rat KW - Morpholines KW - N-(4-hydroxyphenyl)arachidonylamide KW - Naphthalenes KW - Piperidines KW - Pyrazoles KW - Pyridines KW - Receptor, Cannabinoid, CB1 KW - Receptor, Metabotropic Glutamate 5 KW - Receptors, Metabotropic Glutamate KW - Synapsins KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Win 55212-2 KW - 5H31GI9502 KW - 6-methyl-2-(phenylethynyl)pyridine KW - 7VC0YVI27Y KW - glyceryl 2-arachidonate KW - 8D239QDW64 KW - dihydroxyphenylethylene glycol KW - CF5G2G268A KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Naphthalenes -- pharmacology KW - Animals KW - Drug Interactions KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Morpholines -- pharmacology KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Methoxyhydroxyphenylglycol -- analogs & derivatives KW - Synapsins -- metabolism KW - Glycerides -- pharmacology KW - Arachidonic Acids -- pharmacology KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Rats KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - In Vitro Techniques KW - Methoxyhydroxyphenylglycol -- pharmacology KW - gamma-Aminobutyric Acid -- metabolism KW - Pyridines -- pharmacology KW - Benzoxazines -- pharmacology KW - Synapses -- drug effects KW - Synapses -- radiation effects KW - Neurons -- drug effects KW - Receptors, Metabotropic Glutamate -- physiology KW - Inhibitory Postsynaptic Potentials -- drug effects KW - Inhibitory Postsynaptic Potentials -- physiology KW - Cannabinoid Receptor Modulators -- antagonists & inhibitors KW - Inhibitory Postsynaptic Potentials -- radiation effects KW - Cannabinoid Receptor Modulators -- physiology KW - Synapses -- physiology KW - Hippocampus -- cytology KW - Neurons -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69418014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Endocannabinoid-+and+mGluR5-dependent+short-term+synaptic+depression+in+an+isolated+neuron%2Fbouton+preparation+from+the+hippocampal+CA1+region.&rft.au=Sheinin%2C+Anton%3BTalani%2C+Giuseppe%3BDavis%2C+Margaret+I%3BLovinger%2C+David+M&rft.aulast=Sheinin&rft.aufirst=Anton&rft.date=2008-08-01&rft.volume=100&rft.issue=2&rft.spage=1041&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/10.1152%2Fjn.90226.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-05 N1 - Date created - 2008-08-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2001 Mar;29(3):729-38 [11301031] Neuropharmacology. 2008 Jan;54(1):58-67 [17655882] Eur J Neurosci. 2000 Sep;12(9):3239-49 [10998107] FEBS Lett. 2000 Oct 13;483(1):52-6 [11033355] Nature. 2001 Mar 29;410(6828):588-92 [11279497] J Biol Chem. 2001 Aug 17;276(33):31163-70 [11333266] J Neurosci. 2001 Dec 15;21(24):RC188 [11734603] Eur J Neurosci. 2002 Mar;15(6):953-61 [11918654] Nat Neurosci. 2002 Aug;5(8):723-4 [12080342] J Neurosci. 2002 Dec 1;22(23):10182-91 [12451119] Trends Pharmacol Sci. 2003 Jan;24(1):44-7 [12498731] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4269-74 [12655057] J Neurophysiol. 2003 Jul;90(1):55-64 [12649318] Nat Rev Neurosci. 2003 Nov;4(11):873-84 [14595399] Mol Pharmacol. 2004 Mar;65(3):665-74 [14978245] J Biol Chem. 2004 Apr 16;279(16):16377-87 [14963041] Nature. 1990 Aug 9;346(6284):561-4 [2165569] NIDA Res Monogr. 1991;112:129-45 [1753996] J Neurosci Methods. 1991 Jul;38(2-3):145-50 [1784118] J Neurosci. 1992 Oct;12(10):4122-32 [1403103] Nature. 1994 Dec 15;372(6507):686-91 [7990962] Neuron. 1994 Dec;13(6):1447-55 [7993636] Psychopharmacology (Berl). 1996 Jul;126(2):125-31 [8856831] J Physiol. 1996 Oct 1;496 ( Pt 1):197-209 [8910208] Trends Neurosci. 1998 Jan;21(1):8-14 [9464678] J Neurosci. 1999 Jun 1;19(11):4544-58 [10341254] Nature. 1999 Jul 29;400(6743):452-7 [10440374] J Neurosci. 2005 Jun 29;25(26):6199-207 [15987949] Br J Pharmacol. 2005 Aug;145(7):885-93 [15895107] Life Sci. 2005 Aug 19;77(14):1651-66 [15936040] EMBO J. 2005 Sep 7;24(17):3026-37 [16107881] Mol Pharmacol. 2005 Nov;68(5):1196-202 [16051747] J Physiol. 2005 Dec 1;569(Pt 2):501-17 [16179366] J Neurophysiol. 2006 Jan;95(1):67-75 [16207781] Annu Rev Pharmacol Toxicol. 2006;46:101-22 [16402900] Pharmacol Rev. 2006 Sep;58(3):389-462 [16968947] Eur J Pharmacol. 2000 May 12;396(1):39-42 [10822052] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/jn.90226.2008 ER - TY - JOUR T1 - Summary of roundtable discussion on vitamin D research needs. AN - 69409213; 18689407 AB - We summarize the discussions of a roundtable following the conference "Vitamin D and Health in the 21st Century: an Update." The roundtable participants offered additional information on vitamin D research needs from a critical, impartial, and interdisciplinary perspective. Although the group recognized the progress to date, they found that the available evidence on the relation of 25-hydroxyvitamin D, dietary intake, status, functional health, and adverse outcomes has significant limitations because most studies have been short term, have failed to consider important confounders such as baseline vitamin D status and body mass index, and did not study key populations. To meet these data gaps, the roundtable identified several overarching research needs: 1) long-term, high-quality dose-response studies with relevant outcomes, including bone health, other functional outcomes (such as immune function, autoimmune disorders, and chronic disease prevention), and adverse outcomes (such as hypercalcemia and hypercalcuria), especially in understudied population groups such as dark-skinned individuals, infants, adolescents, reproductive-aged women, and pregnant and lactating women; 2) further research to understand the relation of 25-hydroxyvitamin D threshold values to relevant functional outcomes in each life stage and in racial and ethnic groups; 3) further research to understand the metabolic partitioning, fate, and mobilization of key vitamin D metabolites at recommended and greater than recommended intakes to assess the availability of stored vitamin D, relative contributions of endogenously produced and dietary vitamin D, and impact of important confounders (such as body mass index) on vitamin D status; and 4) further research to define the maximal, long-term vitamin D intake to ensure safety for all humans. JF - The American journal of clinical nutrition AU - Brannon, Patsy M AU - Yetley, Elizabeth A AU - Bailey, Regan L AU - Picciano, Mary Frances AD - Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 587S EP - 592S VL - 88 IS - 2 KW - Vitamin D KW - 1406-16-2 KW - Abridged Index Medicus KW - Index Medicus KW - Nutritional Status KW - Ethnic Groups KW - Dose-Response Relationship, Drug KW - Humans KW - Body Mass Index KW - Nutritional Requirements KW - Biomedical Research -- organization & administration KW - Vitamin D -- physiology KW - Nutrition Policy KW - Vitamin D -- adverse effects KW - Vitamin D -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69409213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Summary+of+roundtable+discussion+on+vitamin+D+research+needs.&rft.au=Brannon%2C+Patsy+M%3BYetley%2C+Elizabeth+A%3BBailey%2C+Regan+L%3BPicciano%2C+Mary+Frances&rft.aulast=Brannon&rft.aufirst=Patsy&rft.date=2008-08-01&rft.volume=88&rft.issue=2&rft.spage=587S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=1938-3207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-12 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The relationship of impairment to personality disorder severity among individuals with specific axis I disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 69398444; 18684052 AB - The present study examined one dimensional approach to personality disorders (PDs) in a large (n = 43,093), nationally representative sample of the U.S. population. Respondents were classified in four personality severity categories (no PD, subthreshold PD, simple PD, complex PD). Linear regression analyses were conducted to examine mental disability by PD severity for major DSM-IV substance use, mood and anxiety disorders. Significant increases in disability were observed between no PD and simple PD and between simple PD and complex PD for each Axis I disorder except drug dependence, but few differences in disability were found between no PD and subthreshold PD. This study found support for the clinical utility of the dimensional classification of PD severity with regard to the distinction between simple and complex PD and for a combined no PD-subthreshold PD level of severity. Future planned analyses will address the clinical utility of the classification prospectively, with a full battery of all Axis II PDs. JF - Journal of personality disorders AU - Pulay, Attila J AU - Dawson, Deborah A AU - Ruan, W June AU - Pickering, Roger P AU - Huang, Boji AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health/DHHS, 5635 Fishers Lane, Bethesda, MD 20892, USA. pulaya@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 405 EP - 417 VL - 22 IS - 4 SN - 0885-579X, 0885-579X KW - Index Medicus KW - Severity of Illness Index KW - Anxiety Disorders -- classification KW - Humans KW - Anxiety Disorders -- diagnosis KW - Adult KW - United States -- epidemiology KW - Female KW - Comorbidity KW - Prevalence KW - Alcohol-Related Disorders -- diagnosis KW - Alcohol-Related Disorders -- classification KW - Antisocial Personality Disorder -- epidemiology KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- classification KW - Mentally Ill Persons -- statistics & numerical data KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69398444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality+disorders&rft.atitle=The+relationship+of+impairment+to+personality+disorder+severity+among+individuals+with+specific+axis+I+disorders%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Pulay%2C+Attila+J%3BDawson%2C+Deborah+A%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BHuang%2C+Boji%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Pulay&rft.aufirst=Attila&rft.date=2008-08-01&rft.volume=22&rft.issue=4&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality+disorders&rft.issn=0885579X&rft_id=info:doi/10.1521%2Fpedi.2008.22.4.405 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-04 N1 - Date created - 2008-08-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Stud Alcohol. 1999 Nov;60(6):746-55 [10606485] J Pers Disord. 2000 Summer;14(2):99-108 [10897461] J Pers Disord. 2000 Summer;14(2):109-26 [10897462] Acta Psychiatr Scand. 2000 Oct;102(4):256-64 [11089725] Am J Psychiatry. 2002 Feb;159(2):276-83 [11823271] Lancet. 2002 Jun 29;359(9325):2253-4 [12103293] J Nerv Ment Dis. 2002 Aug;190(8):552-4 [12193841] Alcohol Clin Exp Res. 2003 Feb;27(2):244-52 [12605073] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] J Nerv Ment Dis. 2003 Nov;191(11):706-13 [14614337] Acta Psychiatr Scand. 2004 Feb;109(2):104-9 [14725590] Arch Gen Psychiatry. 2004 Apr;61(4):361-8 [15066894] JAMA. 2004 May 5;291(17):2114-21 [15126440] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Clin Psychiatry. 2004 Jul;65(7):948-58 [15291684] J Clin Psychiatry. 2004 Aug;65(8):1049-56 [15323588] Am J Psychiatry. 2004 Oct;161(10):1743-54 [15465966] Br J Psychiatry. 1979 Aug;135:163-7 [497619] Am J Psychiatry. 1985 May;142(5):553-8 [3985194] Compr Psychiatry. 1986 Jan-Feb;27(1):21-34 [3948501] Arch Gen Psychiatry. 1986 Apr;43(4):329-34 [3954556] J Nerv Ment Dis. 1988 May;176(5):300-4 [3367146] Am J Psychiatry. 1991 Dec;148(12):1647-58 [1957926] Am J Psychiatry. 1992 Feb;149(2):213-20 [1734742] Arch Gen Psychiatry. 1994 Mar;51(3):225-45 [8122959] Am J Psychiatry. 1995 Apr;152(4):571-8 [7694906] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Arch Gen Psychiatry. 1996 Apr;53(4):350-7 [8634013] Am J Psychiatry. 1996 Dec;153(12):1593-7 [8942456] Drug Alcohol Depend. 1997 Mar 14;44(2-3):133-41 [9088785] Drug Alcohol Depend. 1997 Sep 25;47(3):161-9 [9306042] Drug Alcohol Depend. 1997 Sep 25;47(3):171-85 [9306043] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] J Pers Disord. 1997 Fall;11(3):205-31 [9348486] J Pers Disord. 1997 Fall;11(3):242-59 [9348488] Eur Addict Res. 1998 Dec;4(4):144-9 [9852366] J Pers Disord. 1998 Winter;12(4):302-15 [9891285] Alcohol Clin Exp Res. 1999 Jan;23(1):144-50 [10029216] Arch Gen Psychiatry. 2004 Nov;61(11):1107-15 [15520358] J Abnorm Psychol. 2004 Nov;113(4):499-508 [15535783] Compr Psychiatry. 2005 Jan-Feb;46(1):1-5 [15714187] Compr Psychiatry. 2005 Jan-Feb;46(1):20-6 [15714190] J Pers Disord. 2005 Jun;19(3):233-61 [16175735] J Pers Disord. 2005 Jun;19(3):283-302 [16175737] Arch Gen Psychiatry. 2007 Jul;64(7):830-42 [17606817] Addiction. 1999 Jun;94(6):843-55 [10665074] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1521/pedi.2008.22.4.405 ER - TY - JOUR T1 - Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice. AN - 69397432; 18683321 AB - Pten is a negative regulator of the Akt pathway, and its inactivation is believed to be an etiological factor in many tumor types. Pten+/- mice are susceptible to a variety of spontaneous tumor types, depending on strain background. Pten+/- mice, in lung tumor-sensitive and -resistant background strains, were treated with a tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), to determine whether allelic Pten deletion can cooperate with NNK in carcinogenesis in lung or other tissues. In lung tumor-resistant C57BL/6 Pten+/- or +/+ mice, NNK treatment did not lead to any lung tumors and did not increase the incidence or severity of tumors previously reported for this strain. In contrast, in a lung tumor-susceptible pseudo-A/J strain, there was a dose-dependent increase in lung tumor size in Pten+/- compared with +/+ mice, although there was no increase in multiplicity. No other tumor types were observed in pseudo-A/J Pten+/- mice regardless of NNK treatment. Lung tumors from these Pten+/- mice had K-ras mutations, retained Pten expression and had similar Akt pathway activation as lung tumors from +/+ mice. Therefore, deletion of a single copy of Pten does not substantially add to the lung tumor phenotype conferred by mutation of K-ras by NNK, and there is likely no selective advantage for loss of the second Pten allele in lung tumor initiation. JF - Neoplasia (New York, N.Y.) AU - Hollander, Mary Christine AU - Balogh, Andria R AU - Liwanag, Jaminelli AU - Han, Wei AU - Linnoila, Ritva Ilona AU - Anver, Miriam R AU - Dennis, Phillip A AD - Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20889, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 866 EP - 872 VL - 10 IS - 8 KW - Nitrosamines KW - 0 KW - 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone KW - 7S395EDO61 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - PTEN Phosphohydrolase KW - EC 3.1.3.67 KW - Pten protein, mouse KW - Index Medicus KW - Injections, Intraperitoneal KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Genes, ras -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Mice, Transgenic KW - Gene Deletion KW - Phenotype KW - Nitrosamines -- administration & dosage KW - Mice, Inbred A KW - Alleles KW - Genes, ras -- genetics KW - Mice, Inbred C57BL KW - Species Specificity KW - Mutation KW - Gene Expression Regulation, Neoplastic -- genetics KW - Lung Neoplasms -- genetics KW - Lung Neoplasms -- chemically induced KW - PTEN Phosphohydrolase -- metabolism KW - PTEN Phosphohydrolase -- genetics KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69397432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasia+%28New+York%2C+N.Y.%29&rft.atitle=Strain-specific+spontaneous+and+NNK-mediated+tumorigenesis+in+Pten%2B%2F-+mice.&rft.au=Hollander%2C+Mary+Christine%3BBalogh%2C+Andria+R%3BLiwanag%2C+Jaminelli%3BHan%2C+Wei%3BLinnoila%2C+Ritva+Ilona%3BAnver%2C+Miriam+R%3BDennis%2C+Phillip+A&rft.aulast=Hollander&rft.aufirst=Mary&rft.date=2008-08-01&rft.volume=10&rft.issue=8&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Neoplasia+%28New+York%2C+N.Y.%29&rft.issn=1476-5586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-20 N1 - Date created - 2008-08-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Lung Res. 1998 Jul-Aug;24(4):481-97 [9659579] Mol Carcinog. 1993;8(3):177-85 [8216736] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1563-8 [9990064] Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4240-5 [10200246] Hum Pathol. 2005 Jul;36(7):768-76 [16084946] Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13200-5 [16141330] Lung Cancer. 2006 Feb;51(2):181-91 [16324768] Nat Rev Cancer. 2006 Mar;6(3):184-92 [16453012] ILAR J. 2006;47(2):132-40 [16547370] Clin Cancer Res. 2007 Apr 1;13(7):2281-9 [17404113] Cell. 2007 Jun 1;129(5):957-68 [17540175] Crit Rev Oncol Hematol. 2007 Sep;63(3):203-14 [17643312] J Clin Invest. 2007 Oct;117(10):2929-40 [17909629] Cancer Res. 2008 Feb 15;68(4):1119-27 [18281487] Cancer Res. 2000 Jul 1;60(13):3605-11 [10910075] Cancer Res. 2001 May 15;61(10):3986-97 [11358816] Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1455-60 [11818530] J Clin Invest. 2003 Jan;111(1):81-90 [12511591] Methods Mol Biol. 2003;222:97-115 [12710682] J Clin Oncol. 2004 Jul 15;22(14):2954-63 [15254063] J Natl Cancer Inst. 1978 Apr;60(4):819-24 [633391] J Natl Cancer Inst. 1987 Dec;79(6):1351-7 [2891865] Cancer Res. 1989 Oct 1;49(19):5305-11 [2670201] Mol Carcinog. 1990;3(5):279-86 [2244960] Cancer Res. 1992 Jun 1;52(11):3164-73 [1591728] Curr Biol. 1998 Oct 22;8(21):1169-78 [9799734] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human papillomavirus genotype specificity of hybrid capture 2. AN - 69390889; 18579716 AB - Hybrid Capture 2 (hc2), a clinical test for carcinogenic human papillomavirus (HPV) DNA, has proven to be a sensitive but only modestly specific predictor of cervical precancer and cancer risk. Some of its nonspecificity for clinical end points can be ascribed to cross-reactivity with noncarcinogenic HPV genotypes. However, the reference genotyping tests that have been used for these comparisons are also imperfect. We therefore sought to describe further the HPV genotype specificity of hc2 by comparing the hc2 results to paired results from two related PGMY09/11 L1 primer-based HPV genotyping assays: Linear Array (LA) and its prototype predecessor, the line blot assay (LBA). LA and LBA results were considered separately and combined (detection by either assay or both assays) for 37 individual HPV genotypes and HPV risk group categories (carcinogenic HPV > noncarcinogenic HPV > negative). Baseline specimens from 3,179 of 3,488 (91.5%) women referred to ALTS (a clinical trial to evaluate the management strategies for women with atypical squamous cells of undetermined significance [ASCUS] or low-grade squamous intraepithelial lesions) because of an ASCUS Papanicolaou smear were tested by all three assays. Among single-genotype infections with genotypes targeted by hc2 as detected by either PCR assay, HPV genotype 35 (HPV35) (86.4%), HPV56 (84.2%), and HPV58 (76.9%) were the most likely to test positive by hc2. Among single-genotype infections with genotypes not targeted by hc2 as detected by either assay, HPV82 (80.0%), HPV66 (60.0%) (recently classified as carcinogenic), HPV70 (59.1%), and HPV67 (56.3%) were the most likely to test positive by hc2. Among women who tested negative for carcinogenic HPV by both PCR tests and were positive for noncarcinogenic HPV by either test, 28% of women were hc2 positive. Conversely, 7.8% of all hc2-positive results in this population were due to cross-reactivity of hc2 with untargeted, noncarcinogenic HPV genotypes. In conclusion, hc2 cross-reacts with certain untargeted, noncarcinogenic HPV genotypes that are phylogenetically related to the targeted genotypes, but the degree of cross-reactivity may be less than previously reported. JF - Journal of clinical microbiology AU - Castle, Philip E AU - Solomon, Diane AU - Wheeler, Cosette M AU - Gravitt, Patti E AU - Wacholder, Sholom AU - Schiffman, Mark AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 5030, EPS MSC 7234, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 2595 EP - 2604 VL - 46 IS - 8 KW - Index Medicus KW - Sensitivity and Specificity KW - Genotype KW - Humans KW - Clinical Trials as Topic KW - Female KW - Cross Reactions KW - False Positive Reactions KW - Papillomavirus Infections -- diagnosis KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- virology KW - Molecular Diagnostic Techniques -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69390889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Human+papillomavirus+genotype+specificity+of+hybrid+capture+2.&rft.au=Castle%2C+Philip+E%3BSolomon%2C+Diane%3BWheeler%2C+Cosette+M%3BGravitt%2C+Patti+E%3BWacholder%2C+Sholom%3BSchiffman%2C+Mark&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-08-01&rft.volume=46&rft.issue=8&rft.spage=2595&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=1098-660X&rft_id=info:doi/10.1128%2FJCM.00824-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-06 N1 - Date created - 2008-08-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] Br J Cancer. 2008 May 20;98(10):1704-9 [18392052] J Natl Cancer Inst. 2000 Mar 1;92(5):397-402 [10700419] Acta Cytol. 2000 Sep-Oct;44(5):726-42 [11015972] Cancer Epidemiol Biomarkers Prev. 2001 Jan;10(1):45-52 [11205488] J Natl Cancer Inst. 2001 Feb 21;93(4):293-9 [11181776] J Infect Dis. 2001 Jun 1;183(11):1554-64 [11343204] J Med Virol. 2001 Sep;65(1):155-62 [11505458] Acta Obstet Gynecol Scand. 2001 Aug;80(8):750-2 [11531619] Int J Cancer. 2001 Oct 15;94(2):222-7 [11668502] J Clin Microbiol. 2002 Mar;40(3):1088-90 [11880448] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1394-9 [12433717] J Clin Virol. 2002 Dec;25 Suppl 3:S89-97 [12467782] CA Cancer J Clin. 2002 Nov-Dec;52(6):342-62 [12469763] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] Am J Obstet Gynecol. 2003 Jun;188(6):1383-92 [12824967] Am J Obstet Gynecol. 2003 Jun;188(6):1393-400 [12824968] Lancet. 2003 Dec 6;362(9399):1871-6 [14667741] Obstet Gynecol. 2004 Feb;103(2):304-9 [14754700] Virology. 2004 Jun 20;324(1):17-27 [15183049] Virology. 2004 Jul 1;324(2):439-49 [15207629] J Infect Dis. 2004 Aug 1;190(3):458-67 [15243917] Am J Clin Pathol. 2004 Aug;122(2):238-45 [15323141] J Natl Cancer Inst. 1995 Jun 7;87(11):796-802 [7791229] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] J Clin Microbiol. 1998 Nov;36(11):3248-54 [9774574] J Natl Cancer Inst. 2005 Jan 19;97(2):147-50 [15657345] Lancet Oncol. 2005 Apr;6(4):204 [15830458] J Infect Dis. 2005 Jun 1;191(11):1796-807 [15871111] Am J Clin Pathol. 2005 Nov;124(5):722-32 [16203281] Am J Clin Pathol. 2005 Nov;124(5):716-21 [16203283] Cancer Res. 2006 Jan 15;66(2):1218-24 [16424061] Lancet. 2006 Feb 11;367(9509):489-98 [16473126] J Natl Cancer Inst. 2006 Jun 7;98(11):765-74 [16757701] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] Lancet Oncol. 2006 Jul;7(7):547-55 [16814206] J Clin Microbiol. 2006 Nov;44(11):3915-7 [16971652] Am J Clin Pathol. 2007 Mar;127(3):335-7 [17276947] Am J Clin Pathol. 2007 May;127(5):805-15 [17439841] J Clin Microbiol. 2007 May;45(5):1447-54 [17344361] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Am J Obstet Gynecol. 2007 Oct;197(4):340-5 [17904956] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] J Clin Microbiol. 2008 Jan;46(1):109-17 [17989194] J Natl Cancer Inst. 2008 Apr 2;100(7):492-501 [18364502] JAMA. 2000 Jan 5;283(1):87-93 [10632285] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JCM.00824-08 ER - TY - JOUR T1 - FOLFOX2 in the treatment of advanced colorectal cancer: a comparison between elderly and middle aged patients. AN - 69383387; 18676233 AB - The effectiveness of chemotherapy in elderly patients is still a matter of debate. We analyzed the toxicity and efficacy of the original FOLFOX2 regimen in middle aged and elderly patients affected by metastatic colorectal cancer. Consecutive patients with metastatic CRC and measurable disease were eligible. Seventy-eight partially pretreated patients were enrolled: 58 patients were defined as middle aged (70 years). Elderly patients in comparison to middle-aged patients in a higher percentage were males. No significant differences were found in hematological and non-hematological toxicity between the two groups. No significant differences were found in the response rates, time to progression (5.9 vs. 6.0 months respectively), or median overall survival (20.9 and 21.8 months, respectively) between middle aged and elderly patients. The FOLFOX2 regimen provides equivalent feasibility, efficacy, and survival gain in middle-aged and in elderly patients with metastatic CRC. JF - Journal of chemotherapy (Florence, Italy) AU - Berretta, M AU - Bearz, A AU - Frustaci, S AU - Talamini, R AU - Lombardi, D AU - Fratino, L AU - Lleshi, A AU - Bonanno, S AU - Spartà, D AU - Palmucci, S AU - Berretta, S AU - Tirelli, U AD - Division of Medical Oncology A, National Cancer Institute, CRO-IRCCS, Aviano, Italy. mberretta@cro.it Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 503 EP - 508 VL - 20 IS - 4 KW - Organoplatinum Compounds KW - 0 KW - oxaliplatin KW - 04ZR38536J KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Age Factors KW - Organoplatinum Compounds -- administration & dosage KW - Humans KW - Leucovorin -- administration & dosage KW - Disease Progression KW - Aged KW - Leucovorin -- adverse effects KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- therapeutic use KW - Fluorouracil -- adverse effects KW - Organoplatinum Compounds -- adverse effects KW - Aged, 80 and over KW - Adult KW - Organoplatinum Compounds -- therapeutic use KW - Middle Aged KW - Male KW - Female KW - Leucovorin -- therapeutic use KW - Colorectal Neoplasms -- pathology KW - Adenocarcinoma -- secondary KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Adenocarcinoma -- drug therapy KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69383387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemotherapy+%28Florence%2C+Italy%29&rft.atitle=FOLFOX2+in+the+treatment+of+advanced+colorectal+cancer%3A+a+comparison+between+elderly+and+middle+aged+patients.&rft.au=Berretta%2C+M%3BBearz%2C+A%3BFrustaci%2C+S%3BTalamini%2C+R%3BLombardi%2C+D%3BFratino%2C+L%3BLleshi%2C+A%3BBonanno%2C+S%3BSpart%C3%A0%2C+D%3BPalmucci%2C+S%3BBerretta%2C+S%3BTirelli%2C+U&rft.aulast=Berretta&rft.aufirst=M&rft.date=2008-08-01&rft.volume=20&rft.issue=4&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemotherapy+%28Florence%2C+Italy%29&rft.issn=1973-9478&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-28 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity. AN - 69382726; 18676854 AB - B-cell malignancies routinely express surface antigens CD19 and CD22. Immunotoxins against both antigens have been evaluated, and the immunotoxins targeting CD22 are more active. To understand this disparity in cytotoxicity and guide the screening of therapeutic targets, we compared two immunotoxins, FMC63(Fv)-PE38-targeting CD19 and RFB4(Fv)-PE38 (BL22)-targeting CD22. Six lymphoma cell lines have 4- to 9-fold more binding sites per cell for CD19 than for CD22, but BL22 is 4- to 140-fold more active than FMC63(Fv)-PE38, although they have a similar cell binding affinity (Kd, approximately 7 nmol/L). In 1 hour, large amounts of BL22 are internalized (2- to 3-fold more than the number of CD22 molecules on the cell surface), whereas only 5.2% to 16.6% of surface-bound FMC63(Fv)-PE38 is internalized. The intracellular reservoir of CD22 decreases greatly after immunotoxin internalization, indicating that it contributes to the uptake of BL22. Treatment of cells with cycloheximide does not reduce the internalization of BL22. Both internalized immunotoxins are located in the same vesicles. Our results show that the rapid internalization of large amounts of BL22 bound to CD22 makes CD22 a better therapeutic target than CD19 for immunotoxins and probably for other immunoconjugates that act inside cells. JF - Cancer research AU - Du, Xing AU - Beers, Richard AU - Fitzgerald, David J AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA. Y1 - 2008/08/01/ PY - 2008 DA - 2008 Aug 01 SP - 6300 EP - 6305 VL - 68 IS - 15 KW - Antigens, CD19 KW - 0 KW - CD22 protein, human KW - Immunotoxins KW - Sialic Acid Binding Ig-like Lectin 2 KW - Index Medicus KW - Lymphoma, B-Cell -- immunology KW - Humans KW - Lymphoma, B-Cell -- pathology KW - Cell Line, Tumor KW - Antigens, CD19 -- immunology KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Immunotoxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69382726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Differential+cellular+internalization+of+anti-CD19+and+-CD22+immunotoxins+results+in+different+cytotoxic+activity.&rft.au=Du%2C+Xing%3BBeers%2C+Richard%3BFitzgerald%2C+David+J%3BPastan%2C+Ira&rft.aulast=Du&rft.aufirst=Xing&rft.date=2008-08-01&rft.volume=68&rft.issue=15&rft.spage=6300&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-0461 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-08 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods Mol Biol. 2004;248:503-18 [14970517] Blood. 1994 Mar 1;83(5):1329-36 [7509655] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3937-42 [15217923] J Biol Chem. 1982 Feb 25;257(4):1598-601 [6120167] Cancer Res. 1984 Jan;44(1):201-8 [6140077] Cancer Res. 1985 Jan;45(1):69-75 [3871174] Blood. 1987 Mar;69(3):836-40 [3101766] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Clin Cancer Res. 2002 Apr;8(4):995-1002 [11948105] Cancer Res. 2002 Dec 15;62(24):7190-4 [12499256] Cancer. 2003 Mar 15;97(6):1471-80 [12627512] Br J Haematol. 2003 May;121(3):458-61 [12716368] Leuk Lymphoma. 2003 Oct;44(10):1719-25 [14692524] J Immunol. 1995 May 1;154(9):4466-75 [7722303] Res Immunol. 1996 Mar-Apr;147(3):175-88 [8817746] J Immunol. 1996 Nov 15;157(10):4390-8 [8906814] Annu Rev Immunol. 1997;15:481-504 [9143697] Blood. 1997 Sep 1;90(5):2020-6 [9292538] Mol Immunol. 1997 Nov-Dec;34(16-17):1157-65 [9566763] Br J Haematol. 1998 Jul;102(2):509-15 [9695966] Clin Cancer Res. 1998 Nov;4(11):2599-604 [9829722] Nat Biotechnol. 2005 Sep;23(9):1137-46 [16151407] Nat Biotechnol. 2005 Sep;23(9):1147-57 [16151408] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Annu Rev Med. 2007;58:221-37 [17059365] Leukemia. 2007 Jul;21(7):1405-12 [17495978] Mol Cell Biol. 2007 Aug;27(16):5699-710 [17562860] Br J Haematol. 2008 Jan;140(1):46-58 [17991300] Blood. 2008 Jan 1;111(1):338-43 [17895404] J Immunol. 1988 Mar 15;140(6):1791-5 [3257985] Cancer Res. 1988 May 1;48(9):2610-7 [2451562] Blood. 1988 May;71(5):1480-6 [3258772] Immunology. 1988 Jul;64(3):445-50 [3261711] J Immunol. 1988 Dec 15;141(12):4410-7 [2461993] Br J Haematol. 1988 Nov;70(3):289-94 [3264717] Blood. 1989 Feb 15;73(3):753-62 [2465042] Leukemia. 1989 Mar;3(3):170-81 [2465463] J Cell Physiol. 1989 Oct;141(1):222-34 [2528553] J Immunol. 1990 Sep 15;145(6):1974-82 [1697314] Cell Immunol. 1991 Jul;135(2):490-500 [1709828] Cancer Res. 1991 Nov 1;51(21):5876-80 [1933855] Blood. 1992 Feb 1;79(3):576-85 [1370636] Blood. 1992 Nov 1;80(9):2315-20 [1384801] J Clin Oncol. 1993 Apr;11(4):726-37 [7683045] Cancer Res. 1993 Jul 1;53(13):3015-21 [7686448] N Engl J Med. 2004 Mar 11;350(11):1079-80 [15014180] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-0461 ER - TY - JOUR T1 - Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. AN - 69380826; 18474546 AB - Here, we report that diesel exhaust particles (DEPs), a major constituent of urban air pollution, affect blood-brain barrier function at the tissue, cellular, and molecular levels. Isolated rat brain capillaries exposed to DEPs showed increased expression and transport activity of the key drug efflux transporter, P-glycoprotein (6 h EC(50) was approximately 5 microg/ml). Up-regulation of P-glycoprotein was abolished by blocking transcription or protein synthesis. Inhibition of NADPH oxidase or pretreatment of capillaries with radical scavengers ameliorated DEP-induced P-glycoprotein up-regulation, indicating a role for reactive oxygen species in signaling. DEP exposure also increased brain capillary tumor necrosis factor-alpha (TNF-alpha) levels. DEP-induced P-glycoprotein up-regulation was abolished when TNF-receptor 1 (TNF-R1) was blocked and was not evident in experiments with capillaries from TNF-R1 knockout mice. Inhibition of JNK, but not NF-kappaB, blocked DEP-induced P-glycoprotein up-regulation, indicating a role for AP-1 in the signaling pathway. Consistent with this, DEPs increased phosphorylation of c-jun. Together, our results show for the first time that a component of air pollution, DEPs, alters blood-brain barrier function through oxidative stress and proinflammatory cytokine production. These experiments disclose a novel blood-brain barrier signaling pathway, with clear implications for environmental toxicology, CNS pathology, and the pharmacotherapy of CNS disorders. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Hartz, Anika M S AU - Bauer, Björn AU - Block, Michelle L AU - Hong, Jau-Shyong AU - Miller, David S AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 2723 EP - 2733 VL - 22 IS - 8 KW - Cytokines KW - 0 KW - Enzyme Inhibitors KW - Free Radical Scavengers KW - Inflammation Mediators KW - Membrane Glycoproteins KW - P-Glycoprotein KW - Reactive Oxygen Species KW - Receptors, Tumor Necrosis Factor, Type I KW - Tnfrsf1a protein, mouse KW - Vehicle Emissions KW - Cybb protein, rat KW - EC 1.6.- KW - Cybb protein, mouse KW - EC 1.6.3.1 KW - NADPH Oxidase KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - NADPH Oxidase -- antagonists & inhibitors KW - Cytokines -- biosynthesis KW - Membrane Glycoproteins -- antagonists & inhibitors KW - Mice KW - Receptors, Tumor Necrosis Factor, Type I -- genetics KW - Receptors, Tumor Necrosis Factor, Type I -- deficiency KW - Mice, Knockout KW - Rats KW - Rats, Sprague-Dawley KW - Capillaries -- drug effects KW - Up-Regulation -- drug effects KW - Signal Transduction -- drug effects KW - In Vitro Techniques KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - NADPH Oxidase -- genetics KW - Capillaries -- metabolism KW - Free Radical Scavengers -- pharmacology KW - Male KW - Membrane Glycoproteins -- genetics KW - Blood-Brain Barrier -- drug effects KW - Vehicle Emissions -- toxicity KW - P-Glycoprotein -- metabolism KW - Oxidative Stress -- drug effects KW - Blood-Brain Barrier -- physiology KW - Inflammation Mediators -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69380826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Diesel+exhaust+particles+induce+oxidative+stress%2C+proinflammatory+signaling%2C+and+P-glycoprotein+up-regulation+at+the+blood-brain+barrier.&rft.au=Hartz%2C+Anika+M+S%3BBauer%2C+Bj%C3%B6rn%3BBlock%2C+Michelle+L%3BHong%2C+Jau-Shyong%3BMiller%2C+David+S&rft.aulast=Hartz&rft.aufirst=Anika+M&rft.date=2008-08-01&rft.volume=22&rft.issue=8&rft.spage=2723&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.08-106997 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-03 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 Nov 15;414(6861):265-6 [11713514] Cell Transplant. 2007;16(3):285-99 [17503739] Drug Metab Rev. 2002 Feb-May;34(1-2):47-54 [11996011] Science. 2002 May 31;296(5573):1634-5 [12040173] J Clin Invest. 2002 Nov;110(9):1309-18 [12417570] Vascul Pharmacol. 2002 Jun;38(6):339-48 [12529928] Cell Death Differ. 2003 Jan;10(1):45-65 [12655295] J Biol Chem. 2003 Dec 12;278(50):50781-90 [14522998] Toxicol Pathol. 2003 Sep-Oct;31(5):524-38 [14692621] Drug Metab Rev. 2003 Nov;35(4):417-54 [14705869] Environ Health Perspect. 2004 Jun;112(8):820-5 [15175167] Mol Pharmacol. 2004 Sep;66(3):387-94 [15322229] Mol Pharmacol. 2004 Sep;66(3):413-9 [15322232] FASEB J. 2004 Oct;18(13):1618-20 [15319363] Toxicol Pathol. 2004 Nov-Dec;32(6):650-8 [15513908] Environ Health Perspect. 1983 Jan;47:65-80 [6186484] Nature. 1986 May 15-21;321(6067):197-8 [2872594] Nature. 1989 Feb 16;337(6208):661-3 [2537468] Proc Natl Acad Sci U S A. 1989 Apr;86(7):2336-40 [2494664] Adv Exp Med Biol. 1993;331:121-5 [8101423] Am J Physiol. 1995 Jan;268(1 Pt 2):F46-52 [7840247] Cell. 1995 May 19;81(4):495-504 [7758105] Exp Biol Med (Maywood). 2005 Feb;230(2):118-27 [15673560] Environ Health Perspect. 2005 May;113(5):612-7 [15866772] Science. 2005 May 6;308(5723):804-6 [15879201] Electrophoresis. 2005 Jun;26(11):2092-108 [15880549] Nat Rev Neurosci. 2005 Aug;6(8):591-602 [16025095] Stroke. 2005 Dec;36(12):2549-53 [16254223] Blood. 2000 Mar 15;95(6):1891-9 [10706852] Mol Pharmacol. 2000 Dec;58(6):1357-67 [11093774] Blood. 2001 Oct 15;98(8):2389-95 [11588035] Mol Pharmacol. 2006 Feb;69(2):462-70 [16278373] Mol Pharmacol. 2006 Oct;70(4):1212-9 [16837625] Neuroscience. 2006 Nov 3;142(4):1071-9 [16997484] Mol Pharmacol. 2007 Mar;71(3):667-75 [17132686] Toxicol Pathol. 2007 Jan;35(1):154-62 [17325984] Clin Pharmacokinet. 2002;41(2):81-92 [11888329] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1096/fj.08-106997 ER - TY - JOUR T1 - Effect of depot medroxyprogesterone acetate on glucose tolerance in generalized lipodystrophy. AN - 69379288; 18669758 AB - Lipodystrophy is a rare condition causing severe insulin resistance and frank diabetes. Depot medroxyprogesterone acetate (DMPA), a commonly used contraceptive, may worsen glucose tolerance in diabetics and those with lipodystrophy. A young woman with generalized lipodystrophy, who previously required greater than 1,000 units of insulin daily, had a normal hemoglobin A1c on leptin and metformin only. After an injection of DMPA, she developed severe hyperglycemia. Her levels returned to near normal only with extremely high doses of insulin (up to 1,700 units/d) and increased doses of leptin and metformin. Progestin-only contraceptives may detrimentally affect glucose tolerance, particularly in patients with lipodystrophy, a cause of severe insulin resistance and leptin deficiency. One DMPA injection appeared to profoundly alter glucose metabolism in this patient with frank diabetes resulting from lipodystrophy. The effect of progestin-only contraceptives on glucose tolerance should be monitored closely in any diabetic patient. JF - Obstetrics and gynecology AU - Yauger, Belinda J AU - Gorden, Phillip AU - Park, Jean AU - Cochran, Elaine AU - Stratton, Pamela AD - Reproductive Endocrinology and Infertility at National Institutes of Health (NIH), RBMB/NICHD, NIH, Bethesda, MD 20892, USA. yaugerbe@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 445 EP - 447 VL - 112 IS - 2 Pt 2 SN - 0029-7844, 0029-7844 KW - Contraceptive Agents, Female KW - 0 KW - Medroxyprogesterone Acetate KW - C2QI4IOI2G KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Child KW - Adolescent KW - Female KW - Diabetes Complications -- chemically induced KW - Hyperglycemia -- chemically induced KW - Contraceptive Agents, Female -- adverse effects KW - Lipodystrophy, Congenital Generalized -- complications KW - Medroxyprogesterone Acetate -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69379288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Effect+of+depot+medroxyprogesterone+acetate+on+glucose+tolerance+in+generalized+lipodystrophy.&rft.au=Yauger%2C+Belinda+J%3BGorden%2C+Phillip%3BPark%2C+Jean%3BCochran%2C+Elaine%3BStratton%2C+Pamela&rft.aulast=Yauger&rft.aufirst=Belinda&rft.date=2008-08-01&rft.volume=112&rft.issue=2+Pt+2&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/10.1097%2FAOG.0b013e3181662d17 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-09 N1 - Date created - 2008-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Steroids. 1975 Sep;26(3):373-86 [1198624] Obstet Gynecol. 1969 Mar;33(3):383-9 [5776088] N Engl J Med. 2004 Mar 18;350(12):1220-34 [15028826] Recent Prog Horm Res. 2004;59:287-304 [14749507] N Engl J Med. 2002 Feb 21;346(8):570-8 [11856796] J Clin Endocrinol Metab. 1977 Jan;44(1):32-8 [833262] Exp Physiol. 2007 Jan;92(1):241-9 [17068109] Diabetes. 2006 Dec;55 Suppl 2:S9-S15 [17130651] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/AOG.0b013e3181662d17 ER - TY - JOUR T1 - A pilot study of consolidative immunotherapy in patients with high-risk pediatric sarcomas. AN - 69378665; 18676758 AB - Patients with metastatic or recurrent Ewing's sarcoma family of tumors and alveolar rhabdomyosarcoma have <25% 5-year survival in most studies. This study administered a novel immunotherapy regimen aimed at consolidating remission in these patients. Fifty-two patients with translocation positive, recurrent, or metastatic Ewing's sarcoma family of tumors or alveolar rhabdomyosarcoma underwent prechemotherapy cell harvest via apheresis for potential receipt of immunotherapy. Following completion of standard multimodal therapy, 30 patients ultimately initiated immunotherapy and were sequentially assigned to three cohorts. All cohorts received autologous T cells, influenza vaccinations, and dendritic cells pulsed with peptides derived from tumor-specific translocation breakpoints and E7, a peptide known to bind HLA-A2. Cohort 1 received moderate-dose recombinant human interleukin-2 (rhIL-2), cohort 2 received low-dose rhIL-2, and cohort 3 did not receive rhIL-2. All immunotherapy recipients generated influenza-specific immune responses, whereas immune responses to the translocation breakpoint peptides occurred in 39%, and only 25% of HLA-A2(+) patients developed E7-specific responses. Toxicity was minimal. Intention-to-treat analysis revealed a 31% 5-year overall survival for all patients apheresed (median potential follow-up 7.3 years) with a 43% 5-year overall survival for patients initiating immunotherapy. Consolidative immunotherapy is a scientifically based and clinically practical approach for integrating immunotherapy into a multimodal regimen for chemoresponsive cancer. Patients receiving immunotherapy experienced minimal toxicity and favorable survival. The robust influenza immune responses observed suggest that postchemotherapy immune incompetence will not fundamentally limit this approach. Future studies will seek to increase efficacy by using more immunogenic antigens and more potent dendritic cells. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Mackall, Crystal L AU - Rhee, Eunice H AU - Read, Elizabeth J AU - Khuu, Hanh M AU - Leitman, Susan F AU - Bernstein, Donna AU - Tesso, Merertu AU - Long, Lauren M AU - Grindler, David AU - Merino, Margret AU - Kopp, William AU - Tsokos, Maria AU - Berzofsky, Jay A AU - Helman, Lee J AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1104, USA. cm35c@nih.gov Y1 - 2008/08/01/ PY - 2008 DA - 2008 Aug 01 SP - 4850 EP - 4858 VL - 14 IS - 15 SN - 1078-0432, 1078-0432 KW - Index Medicus KW - Humans KW - Pilot Projects KW - Child KW - Recurrence KW - Child, Preschool KW - Infant KW - Blood Component Removal KW - Adult KW - Cohort Studies KW - Neoplasm Metastasis KW - Adolescent KW - Dendritic Cells -- cytology KW - Female KW - Male KW - Sarcoma, Ewing -- therapy KW - Immunotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69378665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+pilot+study+of+consolidative+immunotherapy+in+patients+with+high-risk+pediatric+sarcomas.&rft.au=Mackall%2C+Crystal+L%3BRhee%2C+Eunice+H%3BRead%2C+Elizabeth+J%3BKhuu%2C+Hanh+M%3BLeitman%2C+Susan+F%3BBernstein%2C+Donna%3BTesso%2C+Merertu%3BLong%2C+Lauren+M%3BGrindler%2C+David%3BMerino%2C+Margret%3BKopp%2C+William%3BTsokos%2C+Maria%3BBerzofsky%2C+Jay+A%3BHelman%2C+Lee+J&rft.aulast=Mackall&rft.aufirst=Crystal&rft.date=2008-08-01&rft.volume=14&rft.issue=15&rft.spage=4850&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-08 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bone Marrow Transplant. 1997 Feb;19(3):227-31 [9028550] Semin Hematol. 2006 Jan;43(1):53-61 [16412789] J Clin Invest. 1998 May 15;101(10):2290-6 [9593785] J Clin Invest. 1998 Jul 15;102(2):455-62 [9664088] N Engl J Med. 1999 Jul 29;341(5):342-52 [10423470] Blood. 1999 Aug 1;94(3):1021-7 [10419894] Exp Hematol. 1999 Oct;27(10):1477-86 [10517488] Clin Exp Med. 2004 Oct;4(2):78-85 [15672944] Cancer Immunol Immunother. 2005 Jun;54(6):526-34 [15838707] J Clin Oncol. 2005 Apr 20;23(12):2618-28 [15728225] J Clin Invest. 2005 Apr;115(4):930-9 [15776111] J Immunother. 2005 Sep-Oct;28(5):505-16 [16113607] Br J Cancer. 2005 Oct 3;93(7):749-56 [16136047] Nat Med. 2005 Nov;11(11):1238-43 [16227988] Oncologist. 1999;4(5):370-8 [10551553] J Exp Med. 1999 Dec 6;190(11):1669-78 [10587357] J Clin Oncol. 2000 Sep;18(17):3108-14 [10963639] J Exp Med. 2001 Jan 15;193(2):233-8 [11208863] Cancer Res. 2006 Feb 1;66(3):1818-23 [16452243] J Clin Oncol. 2006 Jul 1;24(19):3089-94 [16809734] N Engl J Med. 2006 Oct 12;355(15):1572-82 [17035650] Pediatr Blood Cancer. 2007 Feb;48(2):132-9 [16317751] J Clin Oncol. 2007 Feb 1;25(4):356-61 [17264330] Cancer Res. 2007 Feb 15;67(4):1842-52 [17293384] Cancer Immunol Immunother. 2007 Jul;56(7):1037-46 [17149595] J Clin Oncol. 2001 Jun 1;19(11):2812-20 [11387352] J Clin Oncol. 2001 Aug 1;19(15):3463-9 [11481351] J Clin Oncol. 2001 Aug 15;19(16):3649-59 [11504746] Cancer Res. 2001 Sep 15;61(18):6868-75 [11559563] Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):931-6 [11792864] Med Pediatr Oncol. 2002 Mar;38(3):158-64 [11836714] J Pediatr Hematol Oncol. 2001 May;23(4):221-4 [11846300] Crit Rev Oncol Hematol. 2002 Feb;41(2):169-89 [11856593] Cytotherapy. 2001;3(1):19-29 [12028840] Science. 2002 Oct 25;298(5594):850-4 [12242449] J Clin Oncol. 2003 Jan 1;21(1):78-84 [12506174] N Engl J Med. 2003 Feb 20;348(8):694-701 [12594313] J Pediatr Surg. 2003 Mar;38(3):347-53 [12632347] Cancer Biol Ther. 2003 Sep-Oct;2(5):579-86 [14614331] Curr Opin Oncol. 2004 Mar;16(2):120-5 [15075902] Nat Med. 2004 Sep;10(9):909-15 [15340416] Cancer. 1983 Jul 1;52(1):44-50 [6850544] Immunol Today. 1990 Nov;11(11):406-10 [2078294] Arch Surg. 1991 Apr;126(4):442-6 [2009059] Adv Immunol. 1991;49:281-355 [1853786] N Engl J Med. 1995 Jan 19;332(3):143-9 [7800006] J Immunol. 1996 Jun 15;156(12):4609-16 [8648103] J Clin Oncol. 1997 Feb;15(2):433-44 [9053463] J Immunol. 1997 Oct 15;159(8):3823-37 [9378970] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4065 ER - TY - JOUR T1 - Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: identification of a phosphorylation site in V2 vasopressin receptor. AN - 69377194; 18578504 AB - Phosphorylation plays vital roles in the regulation and function of the V2 vasopressin receptor (V2R), a G protein-coupled receptor (GPCR) that is responsible for maintaining water homeostasis in the kidney. Through a combination of immunoaffinity purification, immobilized metal affinity chromatography, and nanoflow liquid chromatography tandem mass spectrometry, we identified a novel phosphorylation site (Ser(255)) in the third intracellular loop of human V2R. We showed that the third intracellular loop could be phosphorylated in vitro by protein kinase A, but not by Akt kinase, although sequence motif analysis predicated otherwise. The analytical procedures and methodologies described in this study should be generally applicable for identifying the endogenous phosphorylation sites in other GPCRs, overcoming the limitations of conventional approaches such as sequence motif analysis and site-directed mutagenesis. JF - Analytical chemistry AU - Wu, Shilan AU - Birnbaumer, Mariel AU - Guan, Ziqiang AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park,North Carolina 27709, USA. Y1 - 2008/08/01/ PY - 2008 DA - 2008 Aug 01 SP - 6034 EP - 6037 VL - 80 IS - 15 KW - Phosphoproteins KW - 0 KW - Receptors, G-Protein-Coupled KW - Receptors, Vasopressin KW - Serine KW - 452VLY9402 KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Index Medicus KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Phosphoproteins -- chemistry KW - Phosphorylation KW - Chromatography KW - Receptors, G-Protein-Coupled -- chemistry KW - Humans KW - Receptors, G-Protein-Coupled -- metabolism KW - Phosphoproteins -- analysis KW - Tandem Mass Spectrometry KW - Binding Sites KW - Receptors, Vasopressin -- metabolism KW - Receptors, Vasopressin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69377194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Phosphorylation+analysis+of+G+protein-coupled+receptor+by+mass+spectrometry%3A+identification+of+a+phosphorylation+site+in+V2+vasopressin+receptor.&rft.au=Wu%2C+Shilan%3BBirnbaumer%2C+Mariel%3BGuan%2C+Ziqiang&rft.aulast=Wu&rft.aufirst=Shilan&rft.date=2008-08-01&rft.volume=80&rft.issue=15&rft.spage=6034&rft.isbn=&rft.btitle=&rft.title=Analytical+chemistry&rft.issn=1520-6882&rft_id=info:doi/10.1021%2Fac8008548 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 2000 Nov;58(5):1156-61 [11040065] J Proteome Res. 2008 Mar;7(3):1346-51 [18220336] Nat Biotechnol. 2002 Mar;20(3):301-5 [11875433] FEBS Lett. 2002 Dec 18;532(3):363-6 [12482593] Annu Rev Pharmacol Toxicol. 2004;44:559-609 [14744258] Anal Biochem. 1986 Apr;154(1):250-4 [3085541] Biochemistry. 1986 Nov 4;25(22):6850-3 [3801397] Gene. 1988 Jul 15;67(1):31-40 [3047011] J Biol Chem. 1989 Jul 25;264(21):12657-65 [2545714] J Biol Chem. 1991 Aug 25;266(24):15555-8 [1651913] J Biol Chem. 1992 Jun 15;267(17):11783-8 [1376312] Mol Endocrinol. 1994 Jul;8(7):886-94 [7984150] J Biol Chem. 1996 May 31;271(22):13266-72 [8662816] J Biol Chem. 1997 Jan 24;272(4):2486-92 [8999963] Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2222-6 [9482866] J Biol Chem. 1998 Mar 20;273(12):7155-61 [9507030] Vision Res. 1998 May;38(10):1341-52 [9667002] Annu Rev Biochem. 1998;67:653-92 [9759500] J Biol Chem. 1998 Oct 9;273(41):26549-58 [9756892] Methods. 2005 Mar;35(3):256-64 [15722222] FEBS Lett. 2005 Sep 12;579(22):4985-90 [16115624] Anal Chem. 2007 Jun 15;79(12):4666-73 [17523591] Nature. 2007 Nov 15;450(7168):383-7 [17952055] J Biol Chem. 2001 Apr 20;276(16):13096-103 [11150299] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ac8008548 ER - TY - JOUR T1 - Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. AN - 69375698; 18676839 AB - MicroRNAs are small noncoding RNAs that regulate the expression of protein-coding genes. To evaluate the involvement of microRNAs in prostate cancer, we determined genome-wide expression of microRNAs and mRNAs in 60 primary prostate tumors and 16 nontumor prostate tissues. The mRNA analysis revealed that key components of microRNA processing and several microRNA host genes, e.g., MCM7 and C9orf5, were significantly up-regulated in prostate tumors. Consistent with these findings, tumors expressed the miR-106b-25 cluster, which maps to intron 13 of MCM7, and miR-32, which maps to intron 14 of C9orf5, at significantly higher levels than nontumor prostate. The expression levels of other microRNAs, including a number of miR-106b-25 cluster homologues, were also altered in prostate tumors. Additional differences in microRNA abundance were found between organ-confined tumors and those with extraprostatic disease extension. Lastly, we found evidence that some microRNAs are androgen-regulated and that tumor microRNAs influence transcript abundance of protein-coding target genes in the cancerous prostate. In cell culture, E2F1 and p21/WAF1 were identified as targets of miR-106b, Bim of miR-32, and exportin-6 and protein tyrosine kinase 9 of miR-1. In summary, microRNA expression becomes altered with the development and progression of prostate cancer. Some of these microRNAs regulate the expression of cancer-related genes in prostate cancer cells. JF - Cancer research AU - Ambs, Stefan AU - Prueitt, Robyn L AU - Yi, Ming AU - Hudson, Robert S AU - Howe, Tiffany M AU - Petrocca, Fabio AU - Wallace, Tiffany A AU - Liu, Chang-Gong AU - Volinia, Stefano AU - Calin, George A AU - Yfantis, Harris G AU - Stephens, Robert M AU - Croce, Carlo M AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4258, USA. ambss@mail.nih.gov Y1 - 2008/08/01/ PY - 2008 DA - 2008 Aug 01 SP - 6162 EP - 6170 VL - 68 IS - 15 KW - MicroRNAs KW - 0 KW - RNA, Messenger KW - Ribonuclease III KW - EC 3.1.26.3 KW - Index Medicus KW - Polymerase Chain Reaction KW - Oligonucleotide Array Sequence Analysis KW - Ribonuclease III -- metabolism KW - Humans KW - Aged KW - Middle Aged KW - Up-Regulation KW - Male KW - Gene Expression Profiling KW - MicroRNAs -- genetics KW - Prostatic Neoplasms -- genetics KW - Prostatic Neoplasms -- enzymology KW - RNA, Messenger -- genetics KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69375698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Genomic+profiling+of+microRNA+and+messenger+RNA+reveals+deregulated+microRNA+expression+in+prostate+cancer.&rft.au=Ambs%2C+Stefan%3BPrueitt%2C+Robyn+L%3BYi%2C+Ming%3BHudson%2C+Robert+S%3BHowe%2C+Tiffany+M%3BPetrocca%2C+Fabio%3BWallace%2C+Tiffany+A%3BLiu%2C+Chang-Gong%3BVolinia%2C+Stefano%3BCalin%2C+George+A%3BYfantis%2C+Harris+G%3BStephens%2C+Robert+M%3BCroce%2C+Carlo+M&rft.aulast=Ambs&rft.aufirst=Stefan&rft.date=2008-08-01&rft.volume=68&rft.issue=15&rft.spage=6162&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-0144 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-08 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2000 Mar;20(5):1772-83 [10669753] Cancer Res. 2007 Jun 15;67(12):5699-707 [17575136] Nat Genet. 2007 Aug;39(8):1033-7 [17643101] J Biol Chem. 2007 Aug 10;282(32):23716-24 [17569667] Nature. 2007 Oct 11;449(7163):682-8 [17898713] Mol Cancer Ther. 2007 Oct;6(10):2696-707 [17938263] Nature. 2008 Jan 10;451(7175):147-52 [18185580] Cancer Cell. 2008 Mar;13(3):272-86 [18328430] Mol Cell Biol. 2008 Apr;28(7):2167-74 [18212054] Oncogene. 2008 Mar 13;27(12):1788-93 [17891175] Curr Biol. 2002 Apr 30;12(9):735-9 [12007417] Prostate. 2002 May 15;51(3):211-8 [11967955] N Engl J Med. 2003 Jul 24;349(4):366-81 [12878745] BJU Int. 2003 Aug;92(3):314-8 [12887490] Science. 2004 Jan 2;303(5654):83-6 [14657504] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004 [14973191] Science. 2004 Apr 23;304(5670):594-6 [15105502] Nat Rev Genet. 2004 Jul;5(7):522-31 [15211354] Genome Res. 2004 Oct;14(10A):1902-10 [15364901] Cell. 1993 Nov 19;75(4):817-25 [8242752] Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3602-6 [8170954] RNA. 2005 Mar;11(3):241-7 [15701730] Nature. 2005 Feb 17;433(7027):769-73 [15685193] Cancer Cell. 2005 Mar;7(3):227-38 [15766661] Science. 2005 Apr 22;308(5721):557-60 [15845854] Nature. 2005 Jun 9;435(7043):828-33 [15944707] Nature. 2005 Jun 9;435(7043):834-8 [15944708] Nature. 2005 Jun 9;435(7043):839-43 [15944709] Cancer Res. 2005 Aug 15;65(16):7065-70 [16103053] Prostate. 2006 Jan 1;66(1):70-81 [16114066] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Oncogene. 2006 Feb 16;25(7):1090-8 [16247466] Cancer Cell. 2006 Mar;9(3):189-98 [16530703] EMBO J. 2006 Mar 22;25(6):1184-95 [16511569] Nat Rev Cancer. 2006 Apr;6(4):259-69 [16557279] Cell. 2006 Mar 24;124(6):1169-81 [16564011] Cancer Cell. 2006 Jun;9(6):435-43 [16766263] Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9136-41 [16754881] Genes Dev. 2006 Aug 15;20(16):2202-7 [16882971] Biochem Biophys Res Commun. 2006 Oct 13;349(1):59-68 [16934749] Blood. 2006 Nov 1;108(9):3068-71 [16849646] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Am J Pathol. 2006 Nov;169(5):1812-20 [17071602] Curr Mol Med. 2006 Nov;6(7):731-8 [17100599] Cancer Res. 2007 Feb 15;67(4):1424-9 [17308079] Nat Rev Cancer. 2007 Apr;7(4):256-69 [17384581] Leukemia. 2007 May;21(5):912-6 [17330104] Nat Genet. 2007 May;39(5):673-7 [17401365] JAMA. 2007 May 2;297(17):1901-8 [17473300] Cancer Res. 2007 Jul 1;67(13):6130-5 [17616669] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-0144 ER - TY - JOUR T1 - Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. AN - 69375574; 18559982 AB - Diabetic patients frequently encounter ketosis that is characterized by the breakdown of lipids with the consequent accumulation of ketone bodies. Several studies have demonstrated that reactive species are likely to induce tissue damage in diabetes, but the role of the ketone bodies in the process has not been fully investigated. In this study, electron paramagnetic resonance (EPR) spectroscopy combined with novel spin-trapping and immunological techniques has been used to investigate in vivo free radical formation in a murine model of acetone-induced ketosis. A six-line EPR spectrum consistent with the alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone radical adduct of a carbon-centered lipid-derived radical was detected in the liver extracts. To investigate the possible enzymatic source of these radicals, inducible nitric oxide synthase (iNOS) and NADPH oxidase knockout mice were used. Free radical production was unchanged in the NADPH oxidase knockout but much decreased in the iNOS knockout mice, suggesting a role for iNOS in free radical production. Longer-term exposure to acetone revealed iNOS overexpression in the liver together with protein radical formation, which was detected by confocal microscopy and a novel immunospin-trapping method. Immunohistochemical analysis revealed enhanced lipid peroxidation and protein oxidation as a consequence of persistent free radical generation after 21 days of acetone treatment in control and NADPH oxidase knockout but not in iNOS knockout mice. Taken together, our data demonstrate that acetone administration, a model of ketosis, can lead to protein oxidation and lipid peroxidation through a free radical-dependent mechanism driven mainly by iNOS overexpression. JF - American journal of physiology. Endocrinology and metabolism AU - Stadler, Krisztian AU - Bonini, Marcelo G AU - Dallas, Shannon AU - Duma, Danielle AU - Mason, Ronald P AU - Kadiiska, Maria B AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. stadlerk@niehs.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - E456 EP - E462 VL - 295 IS - 2 SN - 0193-1849, 0193-1849 KW - (pyridyl-4-N-oxide)-N-tert-butylnitrone KW - 0 KW - Free Radicals KW - Proteins KW - Pyridines KW - Acetone KW - 1364PS73AF KW - RNA KW - 63231-63-0 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - NADPH Oxidase -- metabolism KW - Microscopy, Confocal KW - Animals KW - Pyridines -- chemistry KW - Liver -- pathology KW - Lipid Metabolism -- drug effects KW - NADPH Oxidase -- deficiency KW - Acetone -- pharmacology KW - Liver -- metabolism KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Knockout KW - Oxidation-Reduction KW - Liver -- drug effects KW - Protein Carbonylation KW - Electron Spin Resonance Spectroscopy KW - Mice, Inbred C57BL KW - RNA -- chemistry KW - NADPH Oxidase -- genetics KW - Immunohistochemistry KW - Male KW - RNA -- genetics KW - Ketosis -- metabolism KW - Ketosis -- enzymology KW - Ketosis -- chemically induced KW - Nitric Oxide Synthase Type II -- metabolism KW - Nitric Oxide Synthase Type II -- genetics KW - Proteins -- metabolism KW - Free Radicals -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69375574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.atitle=Direct+evidence+of+iNOS-mediated+in+vivo+free+radical+production+and+protein+oxidation+in+acetone-induced+ketosis.&rft.au=Stadler%2C+Krisztian%3BBonini%2C+Marcelo+G%3BDallas%2C+Shannon%3BDuma%2C+Danielle%3BMason%2C+Ronald+P%3BKadiiska%2C+Maria+B&rft.aulast=Stadler&rft.aufirst=Krisztian&rft.date=2008-08-01&rft.volume=295&rft.issue=2&rft.spage=E456&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.issn=01931849&rft_id=info:doi/10.1152%2Fajpendo.00015.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 1982 Dec 23;307(26):1603-10 [6815530] J Biol Chem. 1984 Jan 10;259(1):231-6 [6706932] J Biol Chem. 1986 Mar 25;261(9):3952-7 [3081512] Arch Biochem Biophys. 1987 Nov 15;259(1):149-56 [3688882] J Magn Reson B. 1994 Jun;104(2):105-10 [8049862] Clin Invest Med. 1995 Jun;18(3):193-216 [7554586] Gen Pharmacol. 1996 Jun;27(4):565-73 [8853285] Chem Res Toxicol. 1997 Oct;10(10):1104-8 [9348432] Free Radic Biol Med. 1998 Jan 1;24(1):11-7 [9436609] Free Radic Biol Med. 1998 Jan 1;24(1):175-81 [9436628] Free Radic Biol Med. 1998 Dec;25(9):1083-8 [9870562] Diabetes. 1999 Apr;48(4):855-64 [10102704] Diabetes Care. 1999 Jul;22(7):1171-5 [10388984] Diabetes. 1999 Sep;48(9):1850-5 [10480618] Chem Res Toxicol. 1999 Oct;12(10):1010-8 [10525279] Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4616-21 [16537416] Free Radic Biol Med. 2007 Feb 15;42(4):530-40 [17275685] Diabetes Metab Res Rev. 1999 Nov-Dec;15(6):412-26 [10634967] Free Radic Biol Med. 2000 Oct 15;29(8):721-9 [11053773] Chem Biol Interact. 2001 Jan 30;130-132(1-3):549-62 [11306074] Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13549-53 [11717423] Free Radic Biol Med. 2002 Aug 1;33(3):364-9 [12126758] FASEB J. 2002 Nov;16(13):1713-20 [12409313] Diabetes. 2004 Aug;53(8):2079-86 [15277389] Arch Biochem Biophys. 2004 Oct 15;430(2):284-9 [15369828] Diabetes. 1971 Jul;20(7):485-9 [4997333] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/ajpendo.00015.2008 ER - TY - JOUR T1 - Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. AN - 69374274; 18669456 AB - Sorafenib inhibits Raf kinase and vascular endothelial growth factor (VEGF) receptor. Bevacizumab is a monoclonal antibody targeted against VEGF. We hypothesized that the complementary inhibition of VEGF signaling would have synergistic therapeutic effects. Patients had advanced solid tumors, Eastern Cooperative Oncology Group performance status of 0 to 1, and good end-organ function. A phase I dose-escalation trial of sorafenib and bevacizumab was initiated at below-recommended single-agent doses because of possible overlapping toxicity: sorafenib 200 mg orally twice daily and bevacizumab intravenously at 5 mg/kg (dose level [DL] 1) or 10 mg/kg (DL2) every 2 weeks. Additional patients were enrolled at the maximum-tolerated dose (MTD). Thirty-nine patients were treated. DL1 was the MTD and administered in cohort 2 (N = 27). Dose-limiting toxicity in DL2 was grade 3 proteinuria and thrombocytopenia. Adverse events included hypertension, hand-foot syndrome, diarrhea, transaminitis, and fatigue. Partial responses (PRs) were seen in six (43%) of 13 patients with ovarian cancer (response duration range, 4 to 22+ months) and one of three patients with renal cell cancer (response duration, 14 months). PR or disease stabilization >or= 4 months (median, 6 months; range, 4 to 22+ months) was seen in 22 (59%) of 37 assessable patients. The majority (74%) required sorafenib dose reduction to 200 mg/d at a median of four cycles (range, one to 12 cycles). Combination therapy with sorafenib and bevacizumab has promising clinical activity, especially in patients with ovarian cancer. The rapidity and frequency of sorafenib dose reductions indicates that sorafenib at 200 mg twice daily with bevacizumab 5 mg/kg every 2 weeks may not be tolerable long term, and alternate sorafenib dosing schedules should be explored. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Azad, Nilofer S AU - Posadas, Edwin M AU - Kwitkowski, Virginia E AU - Steinberg, Seth M AU - Jain, Lokesh AU - Annunziata, Christina M AU - Minasian, Lori AU - Sarosy, Gisele AU - Kotz, Herbert L AU - Premkumar, Ahalya AU - Cao, Liang AU - McNally, Deborah AU - Chow, Catherine AU - Chen, Helen X AU - Wright, John J AU - Figg, William D AU - Kohn, Elise C AD - Medical Oncology Branch, Biostatistics and Data Management Section, and Genetics Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/08/01/ PY - 2008 DA - 2008 Aug 01 SP - 3709 EP - 3714 VL - 26 IS - 22 KW - Angiogenesis Inhibitors KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Benzenesulfonates KW - Phenylurea Compounds KW - Protein Kinase Inhibitors KW - Pyridines KW - VEGFA protein, human KW - Vascular Endothelial Growth Factor A KW - Niacinamide KW - 25X51I8RD4 KW - Bevacizumab KW - 2S9ZZM9Q9V KW - sorafenib KW - 9ZOQ3TZI87 KW - Receptors, Vascular Endothelial Growth Factor KW - EC 2.7.10.1 KW - raf Kinases KW - EC 2.7.11.1 KW - Index Medicus KW - Administration, Oral KW - Drug Administration Schedule KW - Receptors, Vascular Endothelial Growth Factor -- antagonists & inhibitors KW - Neoplasm Staging KW - Vascular Endothelial Growth Factor A -- blood KW - Humans KW - Protein Kinase Inhibitors -- administration & dosage KW - Niacinamide -- analogs & derivatives KW - Aged KW - raf Kinases -- antagonists & inhibitors KW - Ovarian Neoplasms -- drug therapy KW - Antibodies, Monoclonal -- administration & dosage KW - Angiogenesis Inhibitors -- administration & dosage KW - Vascular Endothelial Growth Factor A -- antagonists & inhibitors KW - Pyridines -- administration & dosage KW - Benzenesulfonates -- administration & dosage KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Maximum Tolerated Dose KW - Female KW - Male KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Neoplasms -- enzymology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacokinetics KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69374274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Combination+targeted+therapy+with+sorafenib+and+bevacizumab+results+in+enhanced+toxicity+and+antitumor+activity.&rft.au=Azad%2C+Nilofer+S%3BPosadas%2C+Edwin+M%3BKwitkowski%2C+Virginia+E%3BSteinberg%2C+Seth+M%3BJain%2C+Lokesh%3BAnnunziata%2C+Christina+M%3BMinasian%2C+Lori%3BSarosy%2C+Gisele%3BKotz%2C+Herbert+L%3BPremkumar%2C+Ahalya%3BCao%2C+Liang%3BMcNally%2C+Deborah%3BChow%2C+Catherine%3BChen%2C+Helen+X%3BWright%2C+John+J%3BFigg%2C+William+D%3BKohn%2C+Elise+C&rft.aulast=Azad&rft.aufirst=Nilofer&rft.date=2008-08-01&rft.volume=26&rft.issue=22&rft.spage=3709&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2007.10.8332 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-14 N1 - Date created - 2008-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Oncol. 2008 Aug 1;26(22):3665-7 [18669449] Erratum In: J Clin Oncol. 2008 Sep 10;26(26):4363 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2007.10.8332 ER - TY - JOUR T1 - Increased frequency of chromosome translocations associated with diagnostic x-ray examinations. AN - 69372912; 18666821 AB - Informative studies of cancer risks associated with medical radiation are difficult to conduct owing to low radiation doses, poor recall of diagnostic X rays, and long intervals before cancers occur. Chromosome aberrations have been associated with increased cancer risk and translocations are a known radiation biomarker. Seventy-nine U.S. radiologic technologists were selected for blood collection, and translocations were enumerated by whole chromosome painting. We developed a dose score to the red bone marrow for medical radiation exposure from X-ray examinations reported by the technologists that they received as patients. Using Poisson regression, we analyzed translocations in relation to the dose scores. Each dose score unit approximated 1 mGy. The estimated mean cumulative red bone marrow radiation dose score was 42 (range 1-265). After adjustment for age, occupational radiation, and radiotherapy for benign conditions, translocation frequencies significantly increased with increasing red bone marrow dose score with an estimate of 0.007 translocations per 100 CEs per score unit (95% CI, 0.002 to 0.013; P = 0.01). Chromosome damage has been linked with elevated cancer risk, and we found that cumulative radiation exposure from medical X-ray examinations was associated with increased numbers of chromosome translocations. JF - Radiation research AU - Bhatti, Parveen AU - Doody, Michele M AU - Preston, Dale L AU - Kampa, Diane AU - Ron, Elaine AU - Weinstock, Robert W AU - Simon, Steven AU - Edwards, Alan A AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA. bhattip@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 149 EP - 155 VL - 170 IS - 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - United States KW - Radiation Dosage KW - Risk Factors KW - Humans KW - Adult KW - Incidence KW - Middle Aged KW - Risk Assessment -- methods KW - Male KW - Female KW - Translocation, Genetic -- radiation effects KW - Translocation, Genetic -- genetics KW - Occupational Exposure -- statistics & numerical data KW - Radiography -- statistics & numerical data KW - Radiography -- adverse effects KW - Bone Marrow -- radiation effects KW - Occupational Exposure -- analysis KW - Allied Health Personnel -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69372912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Increased+frequency+of+chromosome+translocations+associated+with+diagnostic+x-ray+examinations.&rft.au=Bhatti%2C+Parveen%3BDoody%2C+Michele+M%3BPreston%2C+Dale+L%3BKampa%2C+Diane%3BRon%2C+Elaine%3BWeinstock%2C+Robert+W%3BSimon%2C+Steven%3BEdwards%2C+Alan+A%3BSigurdson%2C+Alice+J&rft.aulast=Bhatti&rft.aufirst=Parveen&rft.date=2008-08-01&rft.volume=170&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1422.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-16 N1 - Date created - 2008-07-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiat Res. 1999 Dec;152(6):655-64 [10581536] Spine (Phila Pa 1976). 2000 Aug 15;25(16):2052-63 [10954636] Radiat Res. 2001 Oct;156(4):337-46 [11554845] Int J Radiat Biol. 2001 Aug;77(8):901-8 [11571024] Radiat Res. 2002 Oct;158(4):424-42 [12236810] Health Phys. 2002 Dec;83(6):907-17 [12467299] Health Phys. 2003 Feb;84(2):245-59 [12553655] Radiat Prot Dosimetry. 2003;103(1):35-40 [12596987] Am J Epidemiol. 2003 Apr 1;157(7):652-63 [12672685] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Health Phys. 2003 Jul;85(1):47-59 [12852471] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13761-6 [14610281] Radiat Prot Dosimetry. 2003;106(2):131-5 [14653333] Lancet. 2004 Jan 31;363(9406):345-51 [15070562] Radiology. 2004 Sep;232(3):735-8 [15273333] Radiat Res. 2004 Sep;162(3):249-56 [15378837] Phys Med Biol. 1981 May;26(3):389-400 [7243876] Radiat Res. 1991 Feb;125(2):214-22 [1996380] Health Phys. 1995 Feb;68(2):266-9 [7814260] Am J Epidemiol. 2007 Jan 1;165(1):36-43 [17071846] Health Phys. 2007 Apr;92(4):315-31 [17351496] Radiat Res. 2007 Jun;167(6):727-34 [17523852] JAMA. 2007 Jul 18;298(3):317-23 [17635892] N Engl J Med. 2007 Nov 29;357(22):2277-84 [18046031] Mutat Res. 1995 Oct;338(1-6):95-106 [7565886] Radiat Res. 1996 Jun;145(6):694-707 [8643829] Radiat Res. 1997 Sep;148(3):216-26 [9291352] Radiat Res. 1998 Jun;149(6):602-13 [9611099] Radiat Prot Dosimetry. 2005;113(4):396-402 [15928034] Radiat Res. 2005 Nov;164(5):612-7 [16238438] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] JAMA. 2006 Aug 9;296(6):638-40 [16896096] Mutat Res. 2006 Aug 30;600(1-2):37-45 [16814813] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1667/RR1422.1 ER - TY - JOUR T1 - In vivo potential effects of adenovirus type 5 E1A and E1B on lung carcinogenesis and lymphoproliferative inflammation. AN - 69367364; 18524829 AB - Triggering uncontrolled cellular proliferation, chronic inflammation, and/or disruption of p53 activity is critical for tumorigenesis initiated by latent viral oncogenes. The adenovirus type 5 (Ad5) early genes E1A and E1B can maintain lifelong latency in the lungs of patients with chronic pulmonary diseases. To determine the in vivo effects of the latent Ad5 E1A and E1B oncogenes, we have examined the influence of Ad5 E1A and E1B gene products on mouse lung carcinogenesis and inflammation by generation and characterization of lung-specific transgenic mouse models. Here, we show that either the Ad5 E1A 243-amino-acid (aa) protein or the E1B 58-kDa protein was dominantly expressed in the transgenic lung. Preferential expression of Ad5 E1A 243-aa protein alone was not sufficient to induce lung carcinogenesis but resulted in low-grade cellular proliferation and high-grade lymphoproliferative inflammation in the lung. The presence of Ad5 E1B dramatically enhanced the expression of the E1A 243-aa protein, in addition to impairing p53 and apoptosis response, resulting in uncontrolled cellular proliferation, lymphoproliferative inflammation, and metastatic carcinomas in the lung after a period of latency. Our studies may provide clues to understanding the potential in vivo biological effects of Ad5 E1A and E1B latent in the lung and a new scope for assessing in vivo functions of viral genes latent in the infection target tissue. JF - Journal of virology AU - Yang, Yongping AU - McKerlie, Colin AU - Lu, Zhan AU - Wang, Lena AU - Buchwald, Manuel AD - Center for Cancer Research, NCI, Frederick, Maryland 21702, USA. yongpiny@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 8105 EP - 8111 VL - 82 IS - 16 KW - Adenovirus E1A Proteins KW - 0 KW - Adenovirus E1B Proteins KW - RNA, Messenger KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Apoptosis KW - RNA, Messenger -- metabolism KW - Adenoviridae Infections KW - Transgenes KW - Neoplasm Metastasis KW - Mice KW - Mice, Transgenic KW - Tumor Suppressor Protein p53 -- metabolism KW - Cell Transformation, Neoplastic KW - Lung Neoplasms -- immunology KW - Lymphoproliferative Disorders -- virology KW - Adenovirus E1A Proteins -- metabolism KW - Adenovirus E1B Proteins -- metabolism KW - Lung Neoplasms -- virology KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69367364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=In+vivo+potential+effects+of+adenovirus+type+5+E1A+and+E1B+on+lung+carcinogenesis+and+lymphoproliferative+inflammation.&rft.au=Yang%2C+Yongping%3BMcKerlie%2C+Colin%3BLu%2C+Zhan%3BWang%2C+Lena%3BBuchwald%2C+Manuel&rft.aulast=Yang&rft.aufirst=Yongping&rft.date=2008-08-01&rft.volume=82&rft.issue=16&rft.spage=8105&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00536-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 2002 Sep 1;100(5):1619-27 [12176880] J Virol. 2002 Sep;76(17):8910-9 [12163610] Virology. 1983 Jul 30;128(2):377-90 [6310863] Mol Cell Biol. 1986 Apr;6(4):1253-60 [2946934] EMBO J. 1987 Nov;6(11):3399-405 [2962857] Epidemiol Infect. 1988 Dec;101(3):503-9 [2850936] Nature. 1992 May 7;357(6373):82-5 [1533443] Am Rev Respir Dis. 1992 Jul;146(1):177-84 [1626800] Genes Dev. 1993 Apr;7(4):535-45 [8384579] Oncogene. 1994 Sep;9(9):2639-47 [8058328] J Virol. 1997 May;71(5):3788-98 [9094654] Virology. 1997 Jul 7;233(2):423-9 [9217065] J Cancer Res Clin Oncol. 1997;123(7):377-82 [9260589] Science. 1998 Apr 10;280(5361):248-53 [9535648] Trends Microbiol. 1999 Apr;7(4):166-71 [10217832] Oncogene. 2005 Jan 6;24(1):55-64 [15480414] Oncogene. 2005 Nov 21;24(52):7686-96 [16299529] J Virol. 2007 Jan;81(1):95-105 [17050591] Immunol Res. 2007;39(1-3):160-72 [17917063] Oncogene. 2000 Jan 20;19(3):452-62 [10656694] Virology. 2000 Apr 10;269(2):404-19 [10753719] J Virol. 2001 Apr;75(7):3089-94 [11238835] Chest. 2002 May;121(5 Suppl):183S-187S [12010848] J Exp Med. 2002 Jun 17;195(12):1515-22 [12070279] Proc Natl Acad Sci U S A. 1979 Dec;76(12):6606-10 [293748] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00536-08 ER - TY - JOUR T1 - Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors. AN - 69357975; 18472184 AB - Based on non-competitive binding interactions we suggested that mu and delta receptors associate as a mu/delta receptor complex in rat brain. We hypothesized that the same non-competitive binding interactions observed in rat brain will be seen in CHO cells that co-express mu and delta receptors, but not in cells that express just mu or delta receptors. We used CHO cells expressing the cloned human mu receptor, cloned human delta receptor, or cloned mouse delta/human mu ("dimer cell"). Cell membranes were prepared from intact cells pretreated with 100nM SUPERFIT. [(3)H][d-Ala(2),d-Leu(5)]enkephalin binding assays followed published procedures. SUPERFIT, a delta-selective irreversible ligand, decreased [(3)H][d-Ala(2),d-Leu(5)]enkephalin binding to delta receptors by approximately 75% and to mu receptors by approximately 50% in dimer cells. SUPERFIT treatment did not decrease [(3)H][d-Ala(2),d-Leu(5)]enkephalin binding to mu cells. The IC(50) values observed in SUPERFIT-treated dimer cells were: [d-Pen(2),d-Pen(5)]enkephalin (1820nM) and morphine (171nM). Saturation binding experiments with SUPERFIT-treated dimer cells showed that [d-Pen(2),d-Pen(5)]enkephalin (5000nM) was a competitive inhibitor. In contrast, morphine (1000nM) lowered the B(max) from 1944fmol/mg to 1276fmol/mg protein (35% decrease). Both [d-Pen(2),d-Pen(5)]enkephalin and morphine competitively inhibited [(3)H][d-Ala(2),d-Leu(5)]enkephalin binding to SUPERFIT-treated mu cells. The results indicate that the mu-delta opioid receptor complex defined on the basis of non-competitive binding interactions in rat brain over 20 years ago likely occurs as a consequence of the formation of mu-delta heterodimers. SUPERFIT-treated dimer cells may provide a useful model to study the properties of mu-delta heterodimers. JF - Peptides AU - Rutherford, John M AU - Wang, Jiabei AU - Xu, Heng AU - Dersch, Christina M AU - Partilla, John S AU - Rice, Kenner C AU - Rothman, Richard B AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1424 EP - 1431 VL - 29 IS - 8 SN - 0196-9781, 0196-9781 KW - Ligands KW - 0 KW - Receptors, Opioid, delta KW - Receptors, Opioid, mu KW - Recombinant Proteins KW - Enkephalin, Leucine-2-Alanine KW - 63631-40-3 KW - Index Medicus KW - Animals KW - Cricetulus KW - Dimerization KW - Humans KW - Enkephalin, Leucine-2-Alanine -- pharmacology KW - Mice KW - Binding Sites KW - CHO Cells KW - Inhibitory Concentration 50 KW - Receptor Aggregation -- drug effects KW - Female KW - Cricetinae KW - Ovary -- metabolism KW - Ovary -- cytology KW - Recombinant Proteins -- metabolism KW - Ovary -- drug effects KW - Receptors, Opioid, delta -- metabolism KW - Receptors, Opioid, mu -- drug effects KW - Receptors, Opioid, mu -- metabolism KW - Receptors, Opioid, delta -- genetics KW - Recombinant Proteins -- genetics KW - Receptors, Opioid, delta -- drug effects KW - Receptors, Opioid, mu -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69357975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Peptides&rft.atitle=Evidence+for+a+mu-delta+opioid+receptor+complex+in+CHO+cells+co-expressing+mu+and+delta+opioid+peptide+receptors.&rft.au=Rutherford%2C+John+M%3BWang%2C+Jiabei%3BXu%2C+Heng%3BDersch%2C+Christina+M%3BPartilla%2C+John+S%3BRice%2C+Kenner+C%3BRothman%2C+Richard+B&rft.aulast=Rutherford&rft.aufirst=John&rft.date=2008-08-01&rft.volume=29&rft.issue=8&rft.spage=1424&rft.isbn=&rft.btitle=&rft.title=Peptides&rft.issn=01969781&rft_id=info:doi/10.1016%2Fj.peptides.2008.03.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-01 N1 - Date created - 2008-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.peptides.2008.03.019 ER - TY - JOUR T1 - Gating the pore of P2X receptor channels. AN - 69353910; 18587390 AB - Three families of ligand-activated ion channels mediate synaptic communication between excitable cells in mammals. For pentameric channels related to nicotinic acetylcholine receptors and tetrameric channels such as glutamate receptors, the pore-forming and gate regions have been studied extensively. In contrast, little is known about the structure of trimeric P2X receptor channels, a family of channels that are activated by ATP and are important in neuronal signaling, pain transmission and inflammation. To identify the pore-forming and gate regions in P2X receptor channels, we introduced cysteine residues throughout the two transmembrane (TM) segments and studied their accessibility to thiol-reactive compounds and ions. Our results show that TM2 lines the central ion-conduction pore, TM1 is positioned peripheral to TM2 and the flow of ions is minimized in the closed state by a gate formed by the external region of TM2. JF - Nature neuroscience AU - Li, Mufeng AU - Chang, Tsg-Hui AU - Silberberg, Shai D AU - Swartz, Kenton J AD - Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, US National Institute of Neurological Disorders and Stroke, US National Institutes of Health, 35 Convent Drive, MSC 3701, Bethesda, Maryland 20892, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 883 EP - 887 VL - 11 IS - 8 KW - Cadmium Compounds KW - 0 KW - Mesylates KW - P2RX2 protein, human KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2X2 KW - (2-(trimethylammonium)ethyl)methanethiosulfonate KW - 155450-08-1 KW - Silver Nitrate KW - 95IT3W8JZE KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Cysteine -- metabolism KW - Kidney -- metabolism KW - Cadmium Compounds -- pharmacology KW - Cysteine -- genetics KW - Humans KW - Kidney -- drug effects KW - Silver Nitrate -- pharmacology KW - Models, Biological KW - Rats KW - Mutagenesis, Site-Directed KW - Protein Structure, Tertiary -- genetics KW - Patch-Clamp Techniques KW - Transfection KW - Amino Acid Substitution -- genetics KW - Kidney -- cytology KW - Protein Structure, Tertiary -- physiology KW - Cell Membrane -- metabolism KW - Cell Line KW - Mesylates -- pharmacology KW - Receptors, Purinergic P2 -- genetics KW - Ion Channel Gating -- physiology KW - Receptors, Purinergic P2 -- drug effects KW - Receptors, Purinergic P2 -- metabolism KW - Ion Channel Gating -- genetics KW - Ion Channel Gating -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69353910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+neuroscience&rft.atitle=Gating+the+pore+of+P2X+receptor+channels.&rft.au=Li%2C+Mufeng%3BChang%2C+Tsg-Hui%3BSilberberg%2C+Shai+D%3BSwartz%2C+Kenton+J&rft.aulast=Li&rft.aufirst=Mufeng&rft.date=2008-08-01&rft.volume=11&rft.issue=8&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Nature+neuroscience&rft.issn=1546-1726&rft_id=info:doi/10.1038%2Fnn.2151 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-22 N1 - Date created - 2008-07-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 1999 Nov;56(5):973-81 [10531403] J Neurosci. 2007 Nov 21;27(47):12916-23 [18032665] Neuron. 2001 Jun;30(3):689-98 [11430803] J Neurosci. 2001 Aug 15;21(16):5885-92 [11487611] J Biol Chem. 2001 Aug 17;276(33):30934-41 [11402044] Nature. 2001 Nov 1;414(6859):43-8 [11689936] Neuron. 2001 Nov 20;32(4):649-56 [11719205] Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3310-4 [18287006] Eur Biophys J. 2009 Mar;38(3):319-27 [18247022] Mol Pharmacol. 2002 Feb;61(2):303-11 [11809854] J Neurosci. 2002 May 15;22(10):3873-80 [12019306] Nature. 2002 Sep 5;419(6902):35-42 [12214225] Physiol Rev. 2002 Oct;82(4):1013-67 [12270951] J Neurosci. 2003 Oct 1;23(26):8903-10 [14523092] J Neurosci. 2004 Mar 31;24(13):3413-20 [15056721] J Mol Biol. 2004 Sep 3;342(1):333-43 [15313628] J Neurosci. 2004 Aug 18;24(33):7378-86 [15317863] J Gen Physiol. 1971 Oct;58(4):413-37 [5112659] Q Rev Biophys. 1974 May;7(2):179-210 [4449982] Pflugers Arch. 1981 Aug;391(2):85-100 [6270629] Neuron. 1993 Mar;10(3):533-41 [8461140] Biochemistry. 1994 Jun 7;33(22):6840-9 [8204619] Nature. 1994 Oct 6;371(6497):519-23 [7523952] Science. 1995 Apr 14;268(5208):304-7 [7716526] Neuropharmacology. 1996;35(7):797-804 [8938712] EMBO J. 1997 Jun 16;16(12):3446-54 [9218787] Neuron. 1997 Jul;19(1):175-84 [9247273] J Neurosci. 1998 Apr 1;18(7):2350-9 [9502796] Science. 1998 Apr 3;280(5360):69-77 [9525859] EMBO J. 1998 Jun 1;17(11):3016-28 [9606184] J Biol Chem. 2005 Mar 18;280(11):10759-65 [15657042] J Gen Physiol. 2005 Apr;125(4):347-59 [15795310] Nature. 2006 Aug 3;442(7102):527-32 [16885977] Neuron. 2007 Apr 19;54(2):263-74 [17442247] Nature. 2007 Sep 20;449(7160):316-23 [17882215] J Biol Chem. 2001 May 4;276(18):14902-8 [11278888] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nn.2151 ER - TY - JOUR T1 - Prevalence and risk factors for carcinogenic human papillomavirus infections in rural Rakai, Uganda. AN - 69342988; 18385223 AB - To investigate self-administered vaginal swabs for assessing prevalence and correlates of carcinogenic human papillomavirus (HPV) infection in rural Rakai, Uganda. 1003 sexually experienced women enrolled in a community cohort provided self-administered vaginal swabs collected at annual, home-based surveys. Carcinogenic HPV prevalence, adjusted odds ratios (AOR), 95% confidence intervals (CI) and associated risk factors were determined. Carcinogenic HPV prevalence was 19.2%: 46.6% among HIV positive and 14.8% among HIV negative women (p<0.001). Type-specific prevalence ranged from 2.0% (HPV 16 and 52) to 0.2% (HPV 31). Age-specific HPV prevalence decreased significantly (p<0.001) among HIV negative women; however, the decrease among HIV positive women was not as pronounced (p = 0.1). Factors independently associated with carcinogenic HPV infection were HIV (AOR 4.82, CI 3.10 to 7.53), age (AOR 4.97, 95% CI 2.19 to 11.26 for 15-19 year olds compared to 40+ years), more than two sex partners in the past year (AOR 2.21, CI 1.10 to 4.43) and self-reported herpes zoster, candidiasis or tuberculosis (AOR 4.52, CI 1.01 to 20.31). Married women were less likely to have prevalent carcinogenic HPV (AOR 0.46, CI 0.30 to 0.70). HPV prevalence and correlates measured using self-administered vaginal swabs were similar to studies that use cervical samples. Thus, self-collection can be used as a substitute for cervical specimens and provide an important tool for research in populations unwilling to undergo pelvic exam. JF - Sexually transmitted infections AU - Safaeian, M AU - Kiddugavu, M AU - Gravitt, P E AU - Gange, S J AU - Ssekasanvu, J AU - Murokora, D AU - Sklar, M AU - Serwadda, D AU - Wawer, M J AU - Shah, K V AU - Gray, R AD - Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA. safaeianm@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 306 EP - 311 VL - 84 IS - 4 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Rural Health KW - Humans KW - Uganda -- epidemiology KW - Tumor Virus Infections -- epidemiology KW - Genotype KW - DNA, Viral -- analysis KW - Risk Factors KW - Adult KW - Polymerase Chain Reaction -- methods KW - Middle Aged KW - Adolescent KW - Female KW - Prevalence KW - Papillomavirus Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69342988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+infections&rft.atitle=Prevalence+and+risk+factors+for+carcinogenic+human+papillomavirus+infections+in+rural+Rakai%2C+Uganda.&rft.au=Safaeian%2C+M%3BKiddugavu%2C+M%3BGravitt%2C+P+E%3BGange%2C+S+J%3BSsekasanvu%2C+J%3BMurokora%2C+D%3BSklar%2C+M%3BSerwadda%2C+D%3BWawer%2C+M+J%3BShah%2C+K+V%3BGray%2C+R&rft.aulast=Safaeian&rft.aufirst=M&rft.date=2008-08-01&rft.volume=84&rft.issue=4&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+infections&rft.issn=1472-3263&rft_id=info:doi/10.1136%2Fsti.2007.027318 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/sti.2007.027318 ER - TY - JOUR T1 - Mineral arsenicals in traditional medicines: orpiment, realgar, and arsenolite. AN - 69334538; 18463319 AB - Mineral arsenicals have long been used in traditional medicines for various diseases, yet arsenic can be highly toxic and carcinogenic. Arsenic in traditional medicines typically comes from deliberate addition for therapeutic purposes, mainly in the form of mineral arsenicals, including orpiment (As2S3), realgar (As4S4), and arsenolite (contains arsenic trioxide, As2O3). Inorganic arsenic is now accepted in Western medicine as a first line chemotherapeutic agent against certain hematopoietic cancers. This perspective analyzes the pharmacology and toxicology of these arsenicals used in traditional medicines. Orpiment and realgar are less soluble and poorly absorbed from the gastrointestinal tract, whereas the bioavailability of arsenic trioxide is similar to inorganic arsenic salts such as sodium arsenite. Pharmacological studies show that arsenic trioxide and realgar are effective against certain malignancies. Orpiment and realgar are used externally for various skin diseases. Realgar is frequently included as an ingredient in oral traditional remedies for its antipyretic, anti-inflammatory, antiulcer, anti-convulsive, and anti-schistosomiasis actions, but the pharmacological basis for this inclusion still remains to be fully justified. Toxicological studies show that cardiovascular toxicity is the major concern for arsenic trioxide and that the gastrointestinal and dermal adverse effects may occur after prolonged use of mineral arsenicals. Little is known regarding the possible secondary cancers resulting from the long-term use of any of these arsenicals. Similar to the safety evaluation of seafood arsenicals, total arsenic content alone appears to be insufficient for mineral arsenical safety evaluation. Arsenic speciation, bioavailability, and toxicity/benefit should be considered in evaluation of mineral arsenical-containing traditional medicines. JF - The Journal of pharmacology and experimental therapeutics AU - Liu, Jie AU - Lu, Yuanfu AU - Wu, Qin AU - Goyer, Robert A AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, NCI at NIEHS, Mail Drop F0-09, Research Triangle Park, NC 27709, USA. liu6@niehs.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 363 EP - 368 VL - 326 IS - 2 KW - Arsenicals KW - 0 KW - Oxides KW - Sulfides KW - arsenic trisulfide KW - 44SIJ800OX KW - arsenic disulfide KW - 56320-22-0 KW - arsenic trioxide KW - S7V92P67HO KW - Index Medicus KW - Molecular Structure KW - Animals KW - Models, Molecular KW - Dose-Response Relationship, Drug KW - Humans KW - Lethal Dose 50 KW - Oxides -- therapeutic use KW - Arsenicals -- therapeutic use KW - Sulfides -- pharmacokinetics KW - Arsenicals -- pharmacokinetics KW - Arsenicals -- chemistry KW - Sulfides -- chemistry KW - Sulfides -- therapeutic use KW - Oxides -- pharmacokinetics KW - Sulfides -- toxicity KW - Oxides -- toxicity KW - Oxides -- chemistry KW - Medicine, Traditional UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69334538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Mineral+arsenicals+in+traditional+medicines%3A+orpiment%2C+realgar%2C+and+arsenolite.&rft.au=Liu%2C+Jie%3BLu%2C+Yuanfu%3BWu%2C+Qin%3BGoyer%2C+Robert+A%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2008-08-01&rft.volume=326&rft.issue=2&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.139543 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-12 N1 - Date created - 2008-07-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Res. 1987 Feb;42(1):72-82 [3803345] Int J Cancer. 1987 Aug 15;40(2):220-3 [3610389] Environ Health Perspect. 1991 Nov;95:205-10 [1821373] Fundam Appl Toxicol. 1993 Feb;20(2):184-9 [8449390] Environ Res. 1995 Jan;68(1):59-67 [7537211] Blood. 1997 May 1;89(9):3354-60 [9129042] J Toxicol Clin Toxicol. 2004;42(6):889-95 [15533028] Curr Opin Hematol. 2005 Jan;12(1):1-6 [15604884] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Mar;25(3):213 [15842139] Biol Trace Elem Res. 2006 Mar;109(3):231-54 [16632893] Zhonghua Xue Ye Xue Za Zhi. 2006 Apr;27(4):259-63 [16875560] Eur J Pharm Sci. 2006 Sep;29(1):35-44 [16824739] Cancer Chemother Pharmacol. 2007 Mar;59(4):485-93 [16937107] Regul Toxicol Pharmacol. 2007 Mar;47(2):204-12 [17092619] J Nanosci Nanotechnol. 2007 Feb;7(2):490-6 [17450784] J Natl Cancer Inst. 2007 May 2;99(9):667-8 [17470732] Gynecol Oncol. 2007 Aug;106(2):400-6 [17512576] Trends Mol Med. 2007 Aug;13(8):353-61 [17644431] J Toxicol Environ Health A. 2007 Oct;70(19):1694-9 [17763088] Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4826-31 [18344322] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):357-64 [17239412] Blood. 2001 Jul 15;98(2):266-71 [11435292] Trends Pharmacol Sci. 2002 Mar;23(3):136-9 [11879681] Blood. 2002 May 1;99(9):3136-43 [11964275] J Ethnopharmacol. 2002 May;80(2-3):147-53 [12007704] Cancer Res. 2002 Jul 15;62(14):3893-903 [12124315] Eur J Clin Pharmacol. 2002 Nov;58(8):521-6 [12451429] Zhongguo Zhong Yao Za Zhi. 2000 Aug;25(8):454-7, 473 [12515204] Toxicol Appl Pharmacol. 2003 Jun 15;189(3):214-20 [12791306] Toxicol Appl Pharmacol. 2003 Dec 15;193(3):309-34 [14678742] Environ Sci Technol. 2004 Feb 15;38(4):1031-7 [14998015] Cell Death Differ. 2004 Jul;11(7):737-46 [15002036] Leuk Res. 2004 Sep;28(9):891-900 [15234563] Zhonghua Xue Ye Xue Za Zhi. 2004 Jun;25(6):359-61 [15308017] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.139543 ER - TY - CONF T1 - Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. AN - 69313649; 18504085 AB - This report is a summary of the symposium on Alcohol, Intestinal Bacterial Growth, Intestinal Permeability to Endotoxin, and Medical Consequences, organized by National Institute on Alcohol Abuse and Alcoholism, Office of Dietary Supplements, and National Institute of Diabetes and Digestive and Kidney Diseases of National Institutes of Health in Rockville, Maryland, October 11, 2006. Alcohol exposure can promote the growth of Gram-negative bacteria in the intestine, which may result in accumulation of endotoxin. In addition, alcohol metabolism by Gram-negative bacteria and intestinal epithelial cells can result in accumulation of acetaldehyde, which in turn can increase intestinal permeability to endotoxin by increasing tyrosine phosphorylation of tight junction and adherens junction proteins. Alcohol-induced generation of nitric oxide may also contribute to increased permeability to endotoxin by reacting with tubulin, which may cause damage to microtubule cytoskeleton and subsequent disruption of intestinal barrier function. Increased intestinal permeability can lead to increased transfer of endotoxin from the intestine to the liver and general circulation where endotoxin may trigger inflammatory changes in the liver and other organs. Alcohol may also increase intestinal permeability to peptidoglycan, which can initiate inflammatory response in liver and other organs. In addition, acute alcohol exposure may potentiate the effect of burn injury on intestinal bacterial growth and permeability. Decreasing the number of Gram-negative bacteria in the intestine can result in decreased production of endotoxin as well as acetaldehyde which is expected to decrease intestinal permeability to endotoxin. In addition, intestinal permeability may be preserved by administering epidermal growth factor, l-glutamine, oats supplementation, or zinc, thereby preventing the transfer of endotoxin to the general circulation. Thus reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries. JF - Alcohol (Fayetteville, N.Y.) AU - Purohit, Vishnudutt AU - Bode, J Christian AU - Bode, Christiane AU - Brenner, David A AU - Choudhry, Mashkoor A AU - Hamilton, Frank AU - Kang, Y James AU - Keshavarzian, Ali AU - Rao, Radhakrishna AU - Sartor, R Balfour AU - Swanson, Christine AU - Turner, Jerrold R Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 349 EP - 361 VL - 42 IS - 5 KW - Endotoxins KW - 0 KW - Glutamine KW - 0RH81L854J KW - Nitric Oxide KW - 31C4KY9ESH KW - Ethanol KW - 3K9958V90M KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Burns -- metabolism KW - Animals KW - Receptor, Epidermal Growth Factor -- metabolism KW - Glutamine -- metabolism KW - Humans KW - Zinc -- metabolism KW - Nitric Oxide -- metabolism KW - Acetaldehyde -- metabolism KW - Probiotics -- therapeutic use KW - Liver Diseases, Alcoholic -- metabolism KW - Permeability KW - Avena -- metabolism KW - Intestinal Mucosa -- drug effects KW - Liver Diseases, Alcoholic -- etiology KW - Endotoxins -- metabolism KW - Bacterial Translocation -- drug effects KW - Ethanol -- adverse effects KW - Alcohol Drinking -- metabolism KW - Intestines -- drug effects KW - Gram-Negative Bacteria -- growth & development KW - Gram-Negative Bacteria -- metabolism KW - Alcohol Drinking -- adverse effects KW - Intestines -- metabolism KW - Endotoxins -- blood KW - Intestines -- microbiology KW - Gram-Negative Bacteria -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69313649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Alcohol%2C+intestinal+bacterial+growth%2C+intestinal+permeability+to+endotoxin%2C+and+medical+consequences%3A+summary+of+a+symposium.&rft.au=Purohit%2C+Vishnudutt%3BBode%2C+J+Christian%3BBode%2C+Christiane%3BBrenner%2C+David+A%3BChoudhry%2C+Mashkoor+A%3BHamilton%2C+Frank%3BKang%2C+Y+James%3BKeshavarzian%2C+Ali%3BRao%2C+Radhakrishna%3BSartor%2C+R+Balfour%3BSwanson%2C+Christine%3BTurner%2C+Jerrold+R&rft.aulast=Purohit&rft.aufirst=Vishnudutt&rft.date=2008-08-01&rft.volume=42&rft.issue=5&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2008.03.131 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-12 N1 - Date created - 2008-07-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol. 1987 Dec;253(6 Pt 1):C854-61 [3425707] J Membr Biol. 1987;100(2):149-64 [3430571] Gut. 1988 Dec;29(12):1621-4 [3065154] Nutr Rev. 1988 Dec;46(12):401-8 [3070446] Hepatology. 1989 Nov;10(5):887-91 [2680869] J Hepatol. 1991 Mar;12(2):162-9 [2050995] J Clin Invest. 1992 Oct;90(4):1313-22 [1401067] Am J Physiol. 1992 Nov;263(5 Pt 2):F915-24 [1279987] Z Gastroenterol. 1993 Jan;31(1):3-7 [8447153] Proc Soc Exp Biol Med. 1994 Mar;205(3):243-7 [8171045] Hepatology. 1994 Aug;20(2):453-60 [8045507] Gastroenterology. 1995 Jan;108(1):218-24 [7806045] J Trauma. 1995 Feb;38(2):198-207 [7869435] Alcohol Clin Exp Res. 1996 Feb;20(1):132-8 [8651442] Gastroenterology. 1996 Oct;111(4):871-85 [8831582] J Gastroenterol Hepatol. 1997 Apr;12(4):305-13 [9195371] Hepatology. 2000 Nov;32(5):1008-17 [11050051] J Immunol. 2001 Apr 1;166(7):4737-42 [11254735] Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1280-8 [11352822] Inflamm Bowel Dis. 2001 May;7(2):94-8 [11383597] Hepatology. 2001 Jul;34(1):101-8 [11431739] Gut. 1998 Feb;42(2):180-7 [9536941] Alcohol Alcohol. 1998 May-Jun;33(3):273-80 [9632053] Am J Physiol. 1998 Oct;275(4 Pt 1):G605-11 [9756487] Alcohol Clin Exp Res. 1998 Nov;22(8):1724-30 [9835287] Am J Physiol. 1999 Apr;276(4 Pt 1):G965-74 [10198341] Am J Pathol. 2005 Feb;166(2):409-19 [15681825] J Food Prot. 2005 Jan;68(1):6-10 [15690797] Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G422-30 [15701621] Burns. 2005 May;31(3):290-6 [15774282] Crit Care Med. 2005 May;33(5):1125-35 [15891348] J Cell Physiol. 2005 Aug;204(2):654-65 [15828022] J Pharmacol Exp Ther. 2001 Nov;299(2):442-8 [11602653] Free Radic Biol Med. 2001 Dec 15;31(12):1544-9 [11744328] Alcohol Alcohol. 2002 Jan-Feb;37(1):81-6 [11825862] Am J Physiol Gastrointest Liver Physiol. 2002 Jun;282(6):G937-47 [12016118] J Lab Clin Med. 2002 May;139(5):311-5 [12032492] Gastroenterology. 2002 Jul;123(1):163-72 [12105845] Am J Gastroenterol. 2002 Aug;97(8):2000-4 [12190167] Alcohol Clin Exp Res. 2002 Aug;26(8 Suppl):75S-80S [12198380] J Gastroenterol. 2002;37(9):726-31 [12375146] Alcohol. 2002 Nov;28(3):137-49 [12551755] Hepatology. 2003 May;37(5):1043-55 [12717385] J Pharmacol Exp Ther. 2003 Jun;305(3):880-6 [12626662] Am J Physiol Cell Physiol. 2003 Oct;285(4):C977-93 [12788694] Surgery. 2003 Sep;134(3):467-73 [14555935] Lab Invest. 2004 Mar;84(3):282-91 [14767487] Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G881-4 [15132946] Am J Pathol. 2004 Jun;164(6):1959-66 [15161632] Alcohol Clin Exp Res. 2004 May;28(5):797-804 [15166657] Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G510-7 [15331350] Am J Physiol. 1997 Oct;273(4 Pt 1):C1378-85 [9357784] Digestion. 1997;58(6):591-5 [9438608] J Membr Biol. 1998 Feb 1;161(3):263-74 [9493132] Nutr Rev. 1998 Feb;56(2 Pt 1):52-60 [9529900] Int J Food Microbiol. 2005 Jul 15;102(2):185-94 [15992617] Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G367-75 [15718285] Toxicol Appl Pharmacol. 2005 Aug 22;207(1):25-38 [15885730] Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G571-8 [15860640] Mol Biol Cell. 2005 Sep;16(9):3919-36 [15958494] Front Biosci. 2006;11:998-1005 [16146791] Pancreas. 2005 Oct;31(3):251-7 [16163057] Ann N Y Acad Sci. 2005 Nov;1056:197-205 [16387688] Lab Invest. 2006 Feb;86(2):191-201 [16402035] J Soc Gynecol Investig. 2006 Feb;13(2):87-96 [16443500] Eur Surg Res. 2005 Nov-Dec;37(6):342-7 [16465058] Am J Pathol. 2006 Apr;168(4):1148-54 [16565490] J Leukoc Biol. 2006 Jun;79(6):1348-56 [16554353] Hepatology. 2006 May;43(5):989-1000 [16628628] Br J Nutr. 2006 Jun;95(6):1177-84 [16768842] J Leukoc Biol. 2006 Aug;80(2):367-75 [16707557] J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S30-3 [16958668] Biochem J. 2007 Mar 1;402(2):291-300 [17087658] J Food Prot. 2007 Feb;70(2):287-91 [17340860] J Toxicol Sci. 2007 Dec;32(5):453-68 [18198478] J Biol Chem. 2008 Feb 8;283(6):3574-83 [17991733] J Pharmacol Exp Ther. 1999 Dec;291(3):1075-85 [10565827] Alcohol Clin Exp Res. 2000 Mar;24(3):390-4 [10776683] J Hepatol. 2000 May;32(5):742-7 [10845660] J Pharmacol Exp Ther. 2000 Sep;294(3):997-1008 [10945852] Am J Physiol Cell Physiol. 2004 Oct;287(4):C1139-51 [15175222] Digestion. 1973 Nov;9(4):293-308 [4204140] Am J Dig Dis. 1978 Jan;23(1):23-32 [563673] Digestion. 1977;16(1-2):87-95 [615740] J Cell Biol. 1979 Apr;81(1):67-82 [573268] Am J Physiol. 1980 Sep;239(3):C75-89 [7435552] Dig Dis Sci. 1981 Nov;26(11):971-7 [7297377] Dig Dis Sci. 1983 Jul;28(7):604-8 [6861590] Digestion. 1983;27(2):70-4 [6414866] Lancet. 1984 Jan 28;1(8370):179-82 [6141332] Hepatogastroenterology. 1984 Feb;31(1):30-4 [6698486] J Hepatol. 1987 Feb;4(1):8-14 [3571935] Am J Physiol. 1987 Jul;253(1 Pt 1):C171-5 [3605327] J Pathol. 1987 May;152(1):47-53 [3305847] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.alcohol.2008.03.131 ER - TY - JOUR T1 - Langerhans cell dogma: another round of rejections. AN - 69312086; 18626480 AB - Mice that are deficient in epidermal Langerhans cells allow the functions of these cells in vivo to be rigorously assessed. Experiments that have been carried out with these animals have yielded surprising results, leading to major changes in existing paradigms. In this issue, Obhrai and coworkers explore the involvement of Langerhans cells in skin graft rejection and describe fascinating results. JF - The Journal of investigative dermatology AU - Udey, Mark C AU - Rosenberg, Amy S AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. udey@helix.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1881 EP - 1883 VL - 128 IS - 8 KW - Diphtheria Toxin KW - 0 KW - Poisons KW - Index Medicus KW - Models, Animal KW - Animals KW - Poisons -- pharmacology KW - Mice, Inbred C57BL KW - Diphtheria Toxin -- pharmacology KW - Mice KW - Mice, Transgenic KW - Male KW - Female KW - Langerhans Cells -- drug effects KW - Langerhans Cells -- pathology KW - Graft Rejection -- immunology KW - Graft Rejection -- pathology KW - Skin Transplantation -- pathology KW - Langerhans Cells -- immunology KW - Skin Transplantation -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69312086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Langerhans+cell+dogma%3A+another+round+of+rejections.&rft.au=Udey%2C+Mark+C%3BRosenberg%2C+Amy+S&rft.aulast=Udey&rft.aufirst=Mark&rft.date=2008-08-01&rft.volume=128&rft.issue=8&rft.spage=1881&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=1523-1747&rft_id=info:doi/10.1038%2Fjid.2008.167 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-29 N1 - Date created - 2008-07-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Invest Dermatol. 2008 Aug;128(8):1950-5 [18337832] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/jid.2008.167 ER - TY - JOUR T1 - Childhood agricultural and adult occupational exposures to organic dusts in a population-based case-control study of systemic lupus erythematosus. AN - 69310756; 18625648 AB - Organic dust exposure can influence the development and symptoms of immune-related diseases such as atopy and asthma, but has rarely been examined in relation to systemic autoimmunity. The present analyses explore the association of lifetime farm and occupational organic dust exposures with systemic lupus erythematosus (SLE) in recently diagnosed patients (n = 265) compared with controls (n = 355) frequency matched by age, sex and state. Questionnaire data included childhood farm residence, childhood and adult experience with specific crops, and adult work in textiles, hog or poultry processing and paper or furniture manufacture. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression models including age, sex, state, race, education and silica exposure. Overall childhood or adult farm contact and childhood farm residence were not associated with SLE. Farm contact with livestock was inversely associated with SLE (OR = 0.55, 95% CI 0.35, 0.88). This effect was most pronounced among those with childhood farm residence and both childhood and adult livestock exposure (OR = 0.19; 95% CI 0.06, 0.63), but was difficult to separate from adult exposure to grains or corn. Other adult occupational exposures were not associated with SLE risk overall, regardless of childhood farm residence or livestock exposure, although an inverse association was seen among non-smokers (OR = 0.59; 95% CI 0.33, 1.1), particularly for textile work (OR = 0.34; 95% CI 0.19, 0.64). These exploratory findings support the development of studies to specifically investigate the effects of organic dust exposure on SLE risk, with particular attention to exposure assessment and characterization of demographics, smoking and other occupational exposures. JF - Lupus AU - Parks, C G AU - Cooper, G S AU - Dooley, M A AU - Park, M M AU - Treadwell, E L AU - Gilkeson, G S AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. parks1@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 711 EP - 719 VL - 17 IS - 8 SN - 0961-2033, 0961-2033 KW - Dust KW - 0 KW - Index Medicus KW - Paper KW - Humans KW - Crops, Agricultural KW - Adult KW - Environmental Exposure KW - Case-Control Studies KW - Animal Husbandry KW - Wood KW - Child KW - Adolescent KW - Male KW - Female KW - Industry KW - Occupational Exposure KW - Agriculture KW - Lupus Erythematosus, Systemic -- immunology KW - Lupus Erythematosus, Systemic -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69310756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lupus&rft.atitle=Childhood+agricultural+and+adult+occupational+exposures+to+organic+dusts+in+a+population-based+case-control+study+of+systemic+lupus+erythematosus.&rft.au=Parks%2C+C+G%3BCooper%2C+G+S%3BDooley%2C+M+A%3BPark%2C+M+M%3BTreadwell%2C+E+L%3BGilkeson%2C+G+S&rft.aulast=Parks&rft.aufirst=C&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Lupus&rft.issn=09612033&rft_id=info:doi/10.1177%2F0961203308089436 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-04 N1 - Date created - 2008-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0961203308089436 ER - TY - JOUR T1 - Insulin-like growth factor-1 promoter polymorphisms and colorectal cancer: a functional genomics approach. AN - 69310614; 18308828 AB - Insulin-like growth factor-1 (IGF1) has been proposed to mediate the obesity-related carcinogenic effects of "Western lifestyle". While genetic factors explain at least half of inter-individual IGF1 variation, the IGF1 polymorphisms hypothesised to underlie the variation in cancer incidence rates remain ill-defined. We used a comparative genomics approach to identify putative regulatory polymorphisms in the IGF1 promoter region within a rapidly westernising population, the Singapore Chinese. Association of IGF1 genotype with colorectal cancer risk was assessed among 298 colorectal cancer cases and 1142 controls nested within the Singapore Chinese Health Study. We identified a common (minor allele frequency = 0.36) single-nucleotide polymorphism (SNP), IGF1-2995 C/A, within a consensus domain for an octamer binding factor (Oct1/Oct2) transcription factor binding site. Possession of one or two copies of the minor allele (genotypes AA and CA) conferred an approximate 40% decrease in risk in comparison to genotype CC (odds ratio, 0.59; 95% confidence interval, 0.45 to 0.77). This association was stronger for colon cancer than for rectal cancer (p(heterogeneity)<0.001) and for those who were physically active versus inactive (p(interaction) = 0.05). Models including other previously identified promoter polymorphisms did not provide a better prediction of colorectal cancer risk. Our results support the hypotheses that IGF1 plays a role in colonic carcinogenesis and that genetically inherited variation in IGF1 expression influences risk of colorectal cancer. JF - Gut AU - Wong, H-L AU - Koh, W-P AU - Probst-Hensch, N M AU - Van den Berg, D AU - Yu, M C AU - Ingles, S A AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DDHS, Rockville, Maryland, USA. Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 1090 EP - 1096 VL - 57 IS - 8 KW - IGFBP3 protein, human KW - 0 KW - Insulin-Like Growth Factor Binding Protein 3 KW - Insulin-Like Growth Factor Binding Proteins KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Abridged Index Medicus KW - Index Medicus KW - Genomics -- methods KW - Humans KW - Aged KW - Insulin-Like Growth Factor Binding Proteins -- blood KW - Body Mass Index KW - Energy Metabolism KW - Evolution, Molecular KW - Phenotype KW - Life Style KW - Genotype KW - Medical Record Linkage KW - Conserved Sequence KW - Middle Aged KW - Effect Modifier, Epidemiologic KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Insulin-Like Growth Factor I -- genetics KW - Polymorphism, Single Nucleotide KW - Insulin-Like Growth Factor I -- metabolism KW - Colorectal Neoplasms -- blood KW - Colorectal Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69310614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gut&rft.atitle=Insulin-like+growth+factor-1+promoter+polymorphisms+and+colorectal+cancer%3A+a+functional+genomics+approach.&rft.au=Wong%2C+H-L%3BKoh%2C+W-P%3BProbst-Hensch%2C+N+M%3BVan+den+Berg%2C+D%3BYu%2C+M+C%3BIngles%2C+S+A&rft.aulast=Wong&rft.aufirst=H-L&rft.date=2008-08-01&rft.volume=57&rft.issue=8&rft.spage=1090&rft.isbn=&rft.btitle=&rft.title=Gut&rft.issn=1468-3288&rft_id=info:doi/10.1136%2Fgut.2007.140855 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2008-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2003 Nov 15;63(22):7708-16 [14633695] Am J Epidemiol. 2003 Sep 1;158(5):424-31 [12936897] Lancet. 2004 Apr 24;363(9418):1346-53 [15110491] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W280-6 [15215395] Cancer Res. 1986 Dec;46(12 Pt 1):6169-73 [3779638] Genetics. 1988 Nov;120(3):849-52 [3224810] Jpn J Cancer Res. 1989 Jan;80(1):51-8 [2540132] Int J Cancer. 1990 Nov 15;46(5):858-63 [2228314] Br J Cancer. 1992 Mar;65(3):341-6 [1558785] Nucleic Acids Res. 1993 Aug 11;21(16):3761-6 [8367293] J Clin Endocrinol Metab. 1994 Feb;78(2):310-2 [8106617] Cancer Epidemiol Biomarkers Prev. 1994 Dec;3(8):687-95 [7881343] Cancer Causes Control. 1995 Mar;6(2):164-79 [7749056] J Clin Invest. 1996 Dec 1;98(11):2612-5 [8958225] Br J Cancer. 1997;75(7):960-8 [9083330] J Cell Physiol. 1998 May;175(2):141-8 [9525472] Genet Epidemiol. 1998;15(2):135-46 [9554552] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11501-3 [9751692] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11763-8 [9751739] J Natl Cancer Inst. 1999 Apr 7;91(7):620-5 [10203281] J Natl Cancer Inst. 1999 Jun 2;91(11):916-32 [10359544] Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):144-51 [15668488] Int J Cancer. 2005 May 20;115(1):148-54 [15688407] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1204-11 [15894673] J Endocrinol. 2005 Sep;186(3):481-9 [16135668] Lancet. 2005 Sep 24-30;366(9491):1059-62 [16182882] Public Health Nutr. 2005 Sep;8(6):620-7 [16236191] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15593-8 [16230630] Hum Mol Genet. 2006 Jan 1;15(1):1-10 [16306136] J Natl Cancer Inst. 2006 Jan 18;98(2):135-8 [16418516] Nucleic Acids Res. 2007 Jan;35(Database issue):D760-5 [17099226] Nat Genet. 2007 Feb;39(2):226-31 [17206142] Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1206-14 [15247132] Science. 2004 Oct 22;306(5696):647-50 [15499010] IARC Sci Publ. 1980;(32):5-338 [7216345] Proc Natl Acad Sci U S A. 1984 Feb;81(3):935-9 [6583688] Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1107-10 [10613344] Cancer Res. 2000 Feb 15;60(4):1070-6 [10706126] Cancer Res. 2000 Apr 1;60(7):2007-17 [10766192] Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):345-9 [10794477] J Pediatr Endocrinol Metab. 2000 May;13(5):497-503 [10803867] J Natl Cancer Inst. 2000 Oct 4;92(19):1592-600 [11018095] Genetics. 2001 Feb;157(2):885-97 [11157005] Am J Epidemiol. 2001 Sep 15;154(6):504-13 [11549555] Nutr Cancer. 2001;39(2):187-95 [11759279] Br J Cancer. 2001 Nov 30;85(11):1695-9 [11742490] Cancer Res. 2002 Feb 15;62(4):1030-5 [11861378] Gut. 2002 May;50(5):642-6 [11950809] J Biol Chem. 2002 Oct 11;277(41):38205-11 [12149254] Lab Invest. 2002 Oct;82(10):1377-89 [12379772] Genome Res. 2003 Jan;13(1):103-7 [12529312] Br J Cancer. 2003 Jan 27;88(2):277-82 [12610514] Exp Biol Med (Maywood). 2003 Apr;228(4):396-405 [12671184] Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):739-46 [12917205] Carcinogenesis. 2004 May;25(5):821-5 [14729596] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/gut.2007.140855 ER - TY - JOUR T1 - Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids. AN - 69303646; 18571270 AB - We reported that reduced dietary intake of polyunsaturated fatty acids (PUFA) such as arachidonic (AA,20:4n6,omega-6) and docosahexaenoic (DHA,22:6n3,omega-3) acids led to alcohol-induced fatty liver and fibrosis. This study was aimed at studying the mechanisms by which a DHA/AA-supplemented diet prevents alcohol-induced fatty liver. Male Long-Evans rats were fed an ethanol or control liquid-diet with or without DHA/AA for 9 weeks. Plasma transaminase levels, liver histology, oxidative/nitrosative stress markers, and activities of oxidatively-modified mitochondrial proteins were evaluated. Chronic alcohol administration increased the degree of fatty liver but fatty liver decreased significantly in rats fed the alcohol-DHA/AA-supplemented diet. Alcohol exposure increased oxidative/nitrosative stress with elevated levels of ethanol-inducible CYP2E1, nitric oxide synthase, nitrite and mitochondrial hydrogen peroxide. However, these increments were normalized in rats fed the alcohol-DHA/AA-supplemented diet. The number of oxidatively-modified mitochondrial proteins was markedly increased following alcohol exposure but significantly reduced in rats fed the alcohol-DHA/AA-supplemented diet. The suppressed activities of mitochondrial aldehyde dehydrogenase, ATP synthase, and 3-ketoacyl-CoA thiolase in ethanol-exposed rats were also recovered in animals fed the ethanol-DHA/AA-supplemented diet. Addition of DHA/AA prevents alcohol-induced fatty liver and mitochondrial dysfunction in an animal model by protecting various mitochondrial enzymes most likely through reducing oxidative/nitrosative stress. JF - Journal of hepatology AU - Song, Byoung-Joon AU - Moon, Kwan-Hoon AU - Olsson, Nils U AU - Salem, Norman AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rm 2S-30, Bethesda, MD 20892-9410, USA. bjs@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 262 EP - 273 VL - 49 IS - 2 SN - 0168-8278, 0168-8278 KW - Central Nervous System Depressants KW - 0 KW - Dietary Fats, Unsaturated KW - Fatty Acids, Unsaturated KW - Reactive Nitrogen Species KW - Reactive Oxygen Species KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Liver -- pathology KW - Rats, Long-Evans KW - Liver -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Reactive Nitrogen Species -- metabolism KW - Rats KW - Central Nervous System Depressants -- toxicity KW - Oxidative Stress KW - Ethanol -- toxicity KW - Nitric Oxide Synthase -- metabolism KW - Male KW - Dietary Fats, Unsaturated -- pharmacology KW - Mitochondrial Diseases -- metabolism KW - Fatty Liver, Alcoholic -- prevention & control KW - Fatty Liver, Alcoholic -- metabolism KW - Mitochondrial Diseases -- diet therapy KW - Fatty Acids, Unsaturated -- pharmacology KW - Mitochondrial Diseases -- prevention & control KW - Fatty Liver, Alcoholic -- diet therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69303646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Prevention+of+alcoholic+fatty+liver+and+mitochondrial+dysfunction+in+the+rat+by+long-chain+polyunsaturated+fatty+acids.&rft.au=Song%2C+Byoung-Joon%3BMoon%2C+Kwan-Hoon%3BOlsson%2C+Nils+U%3BSalem%2C+Norman&rft.aulast=Song&rft.aufirst=Byoung-Joon&rft.date=2008-08-01&rft.volume=49&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=01688278&rft_id=info:doi/10.1016%2Fj.jhep.2008.04.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-09 N1 - Date created - 2008-07-08 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Alcohol Clin Exp Res. 1989 Feb;13(1):15-9 [2646971] Hepatology. 1986 Sep-Oct;6(5):814-22 [3758935] Proc Natl Acad Sci U S A. 1990 Feb;87(4):1620-4 [2154753] Alcohol Alcohol. 1990;25(2-3):127-36 [2142884] J Hepatol. 1991 May;12(3):394-401 [1845298] Biochim Biophys Acta. 1992 Jun 22;1126(2):199-205 [1627623] Toxicol Appl Pharmacol. 1992 Nov;117(1):1-8 [1440602] J Nutr. 1993 Nov;123(11):1939-51 [8229312] Z Naturforsch C. 1994 May-Jun;49(5-6):359-62 [8060461] Arch Biochem Biophys. 1995 Jan 10;316(1):197-205 [7840616] Alcohol Clin Exp Res. 1994 Oct;18(5):1280-5 [7847620] Am J Clin Nutr. 1995 Jun;61(6):1284-9 [7762532] J Nutr. 1995 Oct;125(10):2449-56 [7562078] J Lipid Res. 1964 Oct;5:600-8 [14221106] Gastroenterology. 2004 Dec;127(6):1798-808 [15578517] Pediatr Res. 2005 Mar;57(3):445-52 [15659701] Hepatology. 2005 Sep;42(3):568-77 [16108051] Proteomics. 2006 Feb;6(4):1250-60 [16408314] Biotechnol J. 2006 Apr;1(4):420-39 [16892270] Hepatology. 2006 Nov;44(5):1218-30 [17058263] Hepatology. 2007 Apr;45(4):864-9 [17393517] JAMA. 1995 Nov 8;274(18):1450-5 [7474191] J Biol Chem. 1995 Dec 15;270(50):29632-5 [8530344] Lipids. 1996 Mar;31 Suppl:S153-6 [8729111] Alcohol Clin Exp Res. 1996 Nov;20(8):1418-22 [8947319] Alcohol Clin Exp Res. 1997 Apr;21(2):375-9 [9113278] Hepatology. 1997 Dec;26(6):1386-92 [9397975] Can J Biochem Physiol. 1959 Aug;37(8):911-7 [13671378] Alcohol Clin Exp Res. 2002 Jun;26(6):883-9 [12068258] J Biol Chem. 2003 Jul 25;278(30):27997-8004 [12791698] J Biol Chem. 2003 Sep 19;278(38):36027-31 [12840017] Gastroenterology. 2003 Dec;125(6):1834-44 [14724835] J Nutr. 2004 Apr;134(4):904-12 [15051845] J Biol Chem. 2004 May 21;279(21):22092-101 [15033988] Hepatology. 2004 Sep;40(3):565-73 [15349894] J Biol Chem. 1975 Jul 10;250(13):5122-9 [1171098] Biochem Pharmacol. 1975 Aug 15;24(16):1475-80 [811224] JAMA. 1980 Jul 18;244(3):251-3 [7382090] Prog Lipid Res. 1979;18(2):87-115 [399682] J Pharmacol Methods. 1986 Jun;15(3):225-34 [3713203] Alcohol Alcohol. 1989;24(3):197-211 [2667528] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jhep.2008.04.023 ER - TY - JOUR T1 - Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer. AN - 69242649; 18459106 AB - Perineural invasion (PNI) is the dominant pathway for local invasion in prostate cancer. To date, only few studies have investigated the molecular differences between prostate tumors with PNI and those without it. To evaluate the involvement of both microRNAs and protein-coding genes in PNI, we determined their genome-wide expression with a custom microRNA microarray and Affymetrix GeneChips in 50 prostate adenocarcinomas with PNI and 7 without it. In situ hybridization (ISH) and immunohistochemistry was used to validate candidate genes. Unsupervised classification of the 57 adenocarcinomas revealed two clusters of tumors with distinct global microRNA expression. One cluster contained all non-PNI tumors and a subgroup of PNI tumors. Significance analysis of microarray data yielded a list of microRNAs associated with PNI. At a false discovery rate (FDR)<10%, 19 microRNAs were higher expressed in PNI tumors than in non-PNI tumors. The most differently expressed microRNA was miR-224. ISH showed that this microRNA is expressed by perineural cancer cells. The analysis of protein-coding genes identified 34 transcripts that were differently expressed by PNI status (FDR<10%). These transcripts were down-regulated in PNI tumors. Many of those encoded metallothioneins and proteins with mitochondrial localization and involvement in cell metabolism. Consistent with the microarray data, perineural cancer cells tended to have lower metallothionein expression by immunohistochemistry than nonperineural cancer cells. Although preliminary, our findings suggest that alterations in microRNA expression, mitochondrial function, and cell metabolism occur at the transition from a noninvasive prostate tumor to a tumor with PNI. JF - The Prostate AU - Prueitt, Robyn L AU - Yi, Ming AU - Hudson, Robert S AU - Wallace, Tiffany A AU - Howe, Tiffany M AU - Yfantis, Harris G AU - Lee, Dong H AU - Stephens, Robert M AU - Liu, Chang-Gong AU - Calin, George A AU - Croce, Carlo M AU - Ambs, Stefan AD - Laboratory of Human Carcinogenesis, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892-4258, USA. Y1 - 2008/08/01/ PY - 2008 DA - 2008 Aug 01 SP - 1152 EP - 1164 VL - 68 IS - 11 SN - 0270-4137, 0270-4137 KW - CLMP protein, human KW - 0 KW - Coxsackie and Adenovirus Receptor-Like Membrane Protein KW - MicroRNAs KW - Neoplasm Proteins KW - Receptors, Virus KW - Metallothionein KW - 9038-94-2 KW - Index Medicus KW - Neoplasm Invasiveness KW - Mitochondria -- physiology KW - Cell Lineage -- physiology KW - Oligonucleotide Array Sequence Analysis KW - Cell Differentiation -- physiology KW - Humans KW - Neoplasm Proteins -- genetics KW - Metallothionein -- genetics KW - Receptors, Virus -- genetics KW - Peripheral Nerves -- pathology KW - Male KW - Gene Expression Regulation, Neoplastic KW - Prostatic Neoplasms -- pathology KW - Prostatic Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - MicroRNAs -- physiology KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69242649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prostate&rft.atitle=Expression+of+microRNAs+and+protein-coding+genes+associated+with+perineural+invasion+in+prostate+cancer.&rft.au=Prueitt%2C+Robyn+L%3BYi%2C+Ming%3BHudson%2C+Robert+S%3BWallace%2C+Tiffany+A%3BHowe%2C+Tiffany+M%3BYfantis%2C+Harris+G%3BLee%2C+Dong+H%3BStephens%2C+Robert+M%3BLiu%2C+Chang-Gong%3BCalin%2C+George+A%3BCroce%2C+Carlo+M%3BAmbs%2C+Stefan&rft.aulast=Prueitt&rft.aufirst=Robyn&rft.date=2008-08-01&rft.volume=68&rft.issue=11&rft.spage=1152&rft.isbn=&rft.btitle=&rft.title=The+Prostate&rft.issn=02704137&rft_id=info:doi/10.1002%2Fpros.20786 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-12 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Bioinformatics. 2006;7:30 [16423281] J Clin Pathol. 2006 Jan;59(1):10-6 [16394275] Mol Cancer. 2006;5:14 [16595004] Biochim Biophys Acta. 2006 Jul;1763(7):723-36 [16839620] Int J Radiat Oncol Biol Phys. 2006 Oct 1;66(2):403-7 [16765530] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Prostate. 2006 Feb 15;66(3):266-72 [16245277] BJU Int. 2006 Mar;97(3):485-91 [16469013] BJU Int. 2006 Mar;97(3):492-7 [16469014] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Cancer. 2007 Jan 1;109(1):13-24 [17123267] CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66 [17237035] Mol Cell Biol. 2007 Mar;27(5):1859-67 [17194750] Oncogene. 2007 Apr 26;26(19):2799-803 [17072344] BMC Genomics. 2007;8:240 [17640343] Nature. 2007 Oct 11;449(7163):682-8 [17898713] Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19983-8 [18056640] Mol Cancer. 2008;7:7 [18208603] Prostate. 2000 May 1;43(2):125-35 [10754528] Arch Pathol Lab Med. 2000 Jul;124(7):995-1000 [10888774] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21 [11309499] Prostate. 2001 Nov 1;49(3):213-23 [11746267] Urology. 2002 Jan;59(1):85-90 [11796287] Cancer Cell. 2002 Mar;1(2):203-9 [12086878] Cancer Res. 2002 Jul 1;62(13):3812-8 [12097294] Cancer Res. 2002 Aug 1;62(15):4427-33 [12154050] Gene Ther. 2003 Feb;10(3):198-205 [12571626] Cancer. 2003 Apr 15;97(8):1884-93 [12673714] Hum Pathol. 2003 May;34(5):457-61 [12792919] Neoplasia. 2003 May-Jun;5(3):218-28 [12869305] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 [12883005] Oncogene. 2004 Apr 22;23(19):3487-94 [15007382] Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9740-4 [15210942] Cancer Res. 2004 Sep 1;64(17):6082-90 [15342391] Genome Biol. 2004;5(10):R80 [15461798] Am J Surg Pathol. 1981 Mar;5(2):179-91 [7223929] J Urol. 1989 Sep;142(3):763-8 [2769857] Genomics. 1990 Nov;8(3):513-8 [2286373] Nat Med. 1995 Oct;1(10):1040-5 [7489360] Cancer. 1996 Sep 15;78(6):1267-71 [8826950] Am J Surg Pathol. 1997 Dec;21(12):1496-500 [9414194] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] Am J Surg. 1963 Oct;106:651-67 [14070757] J Urol. 2004 Dec;172(6 Pt 1):2249-51 [15538241] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):719-24 [15647368] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1274-8 [15894685] Nature. 2005 Jun 9;435(7043):834-8 [15944708] Urology. 2005 Nov;66(5):1048-53 [16286122] Nucleic Acids Res. 2005;33(20):e179 [16314309] Nat Rev Cancer. 2006 Apr;6(4):259-69 [16557279] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/pros.20786 ER - TY - JOUR T1 - Substance and Artifact in the Higher-Order Factors of the Big Five AN - 61701941; 200902862 AB - J. M. Digman (1997) proposed that the Big Five personality traits showed a higher-order structure with 2 factors he labeled a and B. These factors have been alternatively interpreted as heritable components of personality or as artifacts of evaluative bias. Using structural equation modeling, the authors reanalyzed data from a cross-national twin study and from American cross-observer studies and analyzed new multimethod data from a German twin study. In all analyses, artifact models outperformed substance models by root-mean-square error of approximation criteria, but models combining both artifact and substance were slightly better. These findings suggest that the search for the biological basis of personality traits may be more profitably focused on the 5 factors themselves and their specific facets, especially in monomethod studies. [Copyright 2008 The American Psychological Association.] JF - Journal of Personality and Social Psychology AU - McCrae, Robert R AU - Yamagata, Shinji AU - Jang, Kerry L AU - Riemann, Rainer AU - Ando, Juko AU - Ono, Yutaka AU - Angleitner, Alois AU - Spinath, Frank M AD - Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825 mccraej@grc.nia.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 442 EP - 455 PB - American Psychological Association, Washington DC VL - 95 IS - 2 SN - 0022-3514, 0022-3514 KW - Big Five, five-factor model, behavior genetics, cross-observer, cross-cultural KW - Genetics KW - Personality Traits KW - Behavior KW - Crosscultural Analysis KW - article KW - 0312: social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61701941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+and+Social+Psychology&rft.atitle=Substance+and+Artifact+in+the+Higher-Order+Factors+of+the+Big+Five&rft.au=McCrae%2C+Robert+R%3BYamagata%2C+Shinji%3BJang%2C+Kerry+L%3BRiemann%2C+Rainer%3BAndo%2C+Juko%3BOno%2C+Yutaka%3BAngleitner%2C+Alois%3BSpinath%2C+Frank+M&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2008-08-01&rft.volume=95&rft.issue=2&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+and+Social+Psychology&rft.issn=00223514&rft_id=info:doi/10.1037%2F0022-3514.95.2.442 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-28 N1 - CODEN - JPSPB2 N1 - SubjectsTermNotLitGenreText - Personality Traits; Behavior; Genetics; Crosscultural Analysis DO - http://dx.doi.org/10.1037/0022-3514.95.2.442 ER - TY - JOUR T1 - The Qualitative and Quantitative Models for Performance Measurement Systems: The Agile Service Development AN - 61682497; 200822619 AB - A decision model for selection using analytic hierarchy process (AHP), however, they did not consider interdependence property but consider independence property among alternatives or criteria. It could become inadequate in measurement of actual performance of the decision process. In order to reduce the decision gap, this paper considers when independence among different elements of a system assumption is violated and takes into account the degree of the interdependence among them. The fuzzy analytic network process (FANP) approach with agile theory is developed to apply in analyzing the new service development in the wholesale center. The FANP could not only offer a hierarchy framework more efficiency and accuracy but also improve human judgment on the importance of requirements involving imprecise and vague. The technique has proved useful for comparing the importance among the determinants of agile for new service development in decision maker's mind, including agile cost, time, robustness and scope. The empirical result points out that 'Diverse designs' of new service development is the best choice for the wholesale center, following as 'Service extended' and 'Technological core'. Adapted from the source document. JF - Quality and Quantity AU - Lin, Ling-Zhong AU - Hsu, Tsuen-Ho AD - Department of Marketing Management, Shih Chien University, 200 University Road, Nei-Men Hsiang, Kaohsiung Hsien, 845, Taiwan ling@mail.kh.usc.edu.tw Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 445 EP - 476 PB - Springer, Dordrecht The Netherlands VL - 42 IS - 4 SN - 0033-5177, 0033-5177 KW - Measurement KW - Performance KW - Qualitative Methods KW - Models KW - Quantitative Methods KW - article KW - 0104: methodology and research technology; research methods/tools UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61682497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+and+Quantity&rft.atitle=The+Qualitative+and+Quantitative+Models+for+Performance+Measurement+Systems%3A+The+Agile+Service+Development&rft.au=Lin%2C+Ling-Zhong%3BHsu%2C+Tsuen-Ho&rft.aulast=Lin&rft.aufirst=Ling-Zhong&rft.date=2008-08-01&rft.volume=42&rft.issue=4&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Quality+and+Quantity&rft.issn=00335177&rft_id=info:doi/10.1007%2Fs11135-006-9053-3 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-09-03 N1 - Number of references - 52 N1 - Last updated - 2016-09-28 N1 - CODEN - QQEJAV N1 - SubjectsTermNotLitGenreText - Qualitative Methods; Quantitative Methods; Models; Measurement; Performance DO - http://dx.doi.org/10.1007/s11135-006-9053-3 ER - TY - JOUR T1 - A letter response to Chaufan's 'How much can a large population study on genes, environments, their interactions and common diseases contribute to the health of the American people?' (65:8, 2007, 1730-1741) AN - 61407455; 200806104 AB - A letter response to Chaufan's "How much can a large population study on gender, environments, their interactions and common diseases contribute to the health of the American people?" )65:8, 2007, 1730-1741). [Copyright 2008 Elsevier Ltd.] JF - Social Science & Medicine AU - Tuckson, Reed V AU - Willard, Huntington F AD - SACGHS Task Force on Large Population Studies, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 673 EP - 674 PB - Elsevier Science, Amsterdam The Netherlands VL - 67 IS - 4 SN - 0277-9536, 0277-9536 KW - Genetics KW - United States of America KW - Health KW - Diseases KW - Sex KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61407455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=A+letter+response+to+Chaufan%27s+%27How+much+can+a+large+population+study+on+genes%2C+environments%2C+their+interactions+and+common+diseases+contribute+to+the+health+of+the+American+people%3F%27+%2865%3A8%2C+2007%2C+1730-1741%29&rft.au=Tuckson%2C+Reed+V%3BWillard%2C+Huntington+F&rft.aulast=Tuckson&rft.aufirst=Reed&rft.date=2008-08-01&rft.volume=67&rft.issue=4&rft.spage=673&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2008.04.011 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-11-06 N1 - Number of references - 3 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Genetics; Sex; Diseases; United States of America; Health DO - http://dx.doi.org/10.1016/j.socscimed.2008.04.011 ER - TY - JOUR T1 - Cancer Survivorship: Rethinking the Cancer Control Continuum AN - 57298764; 200916711 AB - Objectives The implications of the changing face of cancer survivors and the survivorship experience for health promotion are explored. Data Sources National Cancer Institute and Office of Cancer Survivorship, and research and journal articles. Conclusion Health promotion has become one of the most rapidly expanding topics of interest in the broader arena of survivorship research. Implications for Nursing Practice Nurses have been vital champions for a holistic or 'whole person' approach to cancer care and are uniquely positioned to play a central role in ensuring that we deliver on the promise of a valued future life for each cancer survivor and family member alive. Promoting healthy lifestyle behaviors is one of those roles. [Copyright Elsevier B.V.] JF - Seminars in Oncology Nursing AU - Rowland, Julia H Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 145 EP - 152 PB - Elsevier Ltd, The Netherlands VL - 24 IS - 3 SN - 0749-2081, 0749-2081 KW - Cancer survivors cancer survivorship health promotion aging follow-up care survivorship research KW - Medical research KW - Survivors KW - Cancer KW - Control KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57298764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Oncology+Nursing&rft.atitle=Cancer+Survivorship%3A+Rethinking+the+Cancer+Control+Continuum&rft.au=Rowland%2C+Julia+H&rft.aulast=Rowland&rft.aufirst=Julia&rft.date=2008-08-01&rft.volume=24&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Oncology+Nursing&rft.issn=07492081&rft_id=info:doi/10.1016%2Fj.soncn.2008.05.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cancer; Survivors; Health promotion; Medical research; Control DO - http://dx.doi.org/10.1016/j.soncn.2008.05.002 ER - TY - JOUR T1 - Dysthymic and anxiety-related personality traits in bipolar spectrum illness AN - 57298559; 200916785 AB - Anxious and dysthymic personality traits were measured in a euthymic, familial sample of bipolar (BPD) individuals and their affectively ill and unaffected relatives. According to the quantitative genetic model of bipolar spectrum illness [Evans, L., Akiskal, H.S., Keck, Jr., P.E., McElroy, S.L., Sadovnick, A.D., Remick, R.A., Kelsoe, J.R., 2005. Familiality of temperament in bipolar disorder: support for a genetic spectrum. J. Affect. Disord. 85, 153-168], these traits should be normally distributed with the bipolar disorder I (BPD I) group showing the highest and the unaffected relatives the least 'pathological' scores. Three hundred individuals from 47 bipolar disorder families were administered a battery of personality questionnaires (Temperament Evaluation of Memphis, Pisa, Paris, and San Diego; Temperament and Character Inventory; Affective Neuroscience Personality Scale) as well as a self-rating depression (Beck Depression Inventory) and mania (Altman Self-Rating Mania) scale. Out of the 300 participants, 58 were diagnosed with BPD I, 27 with bipolar disorder II (BPD II), 58 with recurrent major depression (MDE-R), 45 had one previous depressive episode (MDE-S), and 88 were unaffected. The BPD I group scored significantly higher than their unaffected relatives on the Harm Avoidance and Sadness scales of the TCI and ANPS, respectively, while the MDE-R but not the BPD samples scored significantly higher than unaffected relatives on the Anxious Temperament (AT) subscale of the TEMPS-A. In general, the mean dysthymic personality scores were highest in the BPD sample, followed by the MDE-R, MDE-S, and unaffected relative groups. Nevertheless, no significant personality differences were found between the psychiatrically-ill groups. While dysthymic temperament traits conform relatively well to the quantitative genetic model of affective illness, anxious traits as defined by the AT scale, are equally salient in BPD and unipolar depression. [Copyright Elsevier B.V.] JF - Journal of Affective Disorders AU - Savitz, Jonathan AU - van der Merwe, Lize AU - Ramesar, Rajkumar AD - Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, United States savitzj@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 305 EP - 311 PB - Elsevier Ltd, The Netherlands VL - 109 IS - 3 SN - 0165-0327, 0165-0327 KW - Bipolar disorder Spectrum Personality Quantitative Model KW - Mania KW - Anxiety disorders KW - Bipolar affective disorder KW - Personality KW - Temperament KW - Personality tests KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57298559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Affective+Disorders&rft.atitle=Dysthymic+and+anxiety-related+personality+traits+in+bipolar+spectrum+illness&rft.au=Savitz%2C+Jonathan%3Bvan+der+Merwe%2C+Lize%3BRamesar%2C+Rajkumar&rft.aulast=Savitz&rft.aufirst=Jonathan&rft.date=2008-08-01&rft.volume=109&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Journal+of+Affective+Disorders&rft.issn=01650327&rft_id=info:doi/10.1016%2Fj.jad.2007.12.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Personality; Temperament; Personality tests; Anxiety disorders; Mania DO - http://dx.doi.org/10.1016/j.jad.2007.12.006 ER - TY - JOUR T1 - The National Cancer Institute's Transdisciplinary Centers Initiatives and the Need for Building a Science of Team Science AN - 57269479; 200821258 AB - After summarizing the emergence & development of inter- or transdisciplinary team science centers to address public-health problems, the need for methods to evaluate the effectiveness of such efforts in comparison to traditional, discipline-specific approaches is discussed. A case is made for the creation of a "science of team science" for the purposes of such evaluation; benefits of such an approach are delineated. The need to expand the interface between interdisciplinary science teams & public health policy is also discussed. References. K. Hyatt Stewart [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Croyle, Robert T AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland croyler@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - S90 EP - S93 PB - Elsevier Science, New York NY VL - 35 IS - 2S1 SN - 0749-3797, 0749-3797 KW - Interdisciplinary team work KW - Scientific research KW - Health policy KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57269479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=The+National+Cancer+Institute%27s+Transdisciplinary+Centers+Initiatives+and+the+Need+for+Building+a+Science+of+Team+Science&rft.au=Croyle%2C+Robert+T&rft.aulast=Croyle&rft.aufirst=Robert&rft.date=2008-08-01&rft.volume=35&rft.issue=2S1&rft.spage=S90&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.05.012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Interdisciplinary team work; Public health; Health policy; Scientific research DO - http://dx.doi.org/10.1016/j.amepre.2008.05.012 ER - TY - JOUR T1 - Interdisciplinarity and Systems Science to Improve Population Health: A View from the NIH Office of Behavioral and Social Sciences Research AN - 57268260; 200822077 AB - Fueled by the rapid pace of discovery, humankind's ability to understand the ultimate causes of preventable common disease burdens and to identify solutions is now reaching a revolutionary tipping point. Achieving optimal health and well-being for all members of society lies as much in the understanding of the factors identified by the behavioral, social, and public health sciences as by the biological ones. Accumulating advances in mathematical modeling, informatics, imaging, sensor technology, and communication tools have stimulated several converging trends in science: an emerging understanding of epigenomic regulation; dramatic successes in achieving population health-behavior changes; and improved scientific rigor in behavioral, social, and economic sciences. Fostering stronger interdisciplinary partnerships to bring together the behavioral-social-ecologic models of multilevel 'causes of the causes' and the molecular, cellular, and, ultimately, physiological bases of health and disease will facilitate breakthroughs to improve the public's health. The strategic vision of the Office of Behavioral and Social Sciences Research (OBSSR) at the National Institutes of Health (NIH) is rooted in a collaborative approach to addressing the complex and multidimensional issues that challenge the public's health. This paper describes OBSSR's four key programmatic directions (next-generation basic science, interdisciplinary research, systems science, and a problem-based focus for population impact) to illustrate how interdisciplinary and transdisciplinary perspectives can foster the vertical integration of research among biological, behavioral, social, and population levels of analysis over the lifespan and across generations. Interdisciplinary and multilevel approaches are critical both to the OBSSR's mission of integrating behavioral and social sciences more fully into the NIH scientific enterprise and to the overall NIH mission of utilizing science in the pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Mabry, Patricia L AU - Olster, Deborah H AU - Morgan, Glen D AU - Abrams, David B AD - Office of Behavioral and Social Sciences Research, Office of the Director, NIH, Bethesda, Maryland mabryp@od.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - S211 EP - S224 PB - Elsevier Science, New York NY VL - 35 IS - 2S1 SN - 0749-3797, 0749-3797 KW - Technological innovation KW - Interdisciplinary research KW - Preventive health care KW - Health behaviour KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57268260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Interdisciplinarity+and+Systems+Science+to+Improve+Population+Health%3A+A+View+from+the+NIH+Office+of+Behavioral+and+Social+Sciences+Research&rft.au=Mabry%2C+Patricia+L%3BOlster%2C+Deborah+H%3BMorgan%2C+Glen+D%3BAbrams%2C+David+B&rft.aulast=Mabry&rft.aufirst=Patricia&rft.date=2008-08-01&rft.volume=35&rft.issue=2S1&rft.spage=S211&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.05.018 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Public health; Health behaviour; Technological innovation; Interdisciplinary research; Preventive health care DO - http://dx.doi.org/10.1016/j.amepre.2008.05.018 ER - TY - JOUR T1 - Sisters in hereditary breast and ovarian cancer families: communal coping, social integration, and psychological well-being AN - 57263658; 200821928 AB - Objective: We investigated the association between psychological distress and indices of social integration and communal coping among sisters from hereditary breast and ovarian cancer (HBOC) families. Sample and methods: Sixty-five sisters from 31 HBOC families completed the Brief Symptom Inventory-18 and the Colored Eco-Genetic Relationship Map, which identified members of participants' social support networks. Hierarchical linear models were used for all analyses to account for the clustering of sisters within families. Results: Intra-family correlation coefficients suggested that sisters shared perceptions of breast cancer risk and worry, but not ovarian cancer risk and worry. Further, sisters demonstrated shared levels of anxiety and somatization, but not depressive symptoms. Communal coping indices quantifying shared support resources were negatively related to anxiety and somatization. The number of persons with whom cancer risk information was shared exhibited a positive trend with somatization. Social integration, as measured by the size of participants' emotional support network, was negatively associated with anxiety. Lower depression scores were observed among participants with more persons playing multiple support roles and fewer persons providing tangible assistance. Conclusion: Understanding how support relationships impact well-being among persons adjusting to HBOC risk, and the particular role of family in that process, will facilitate developing appropriate management approaches to help cancer-prone families adjust to their cancer risk. [Copyright 2008 John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Koehly, Laura M AU - Peters, June A AU - Kuhn, Natalia AU - Hoskins, Lindsey AU - Letocha, Anne AU - Kenen, Regina AU - Loud, Jennifer AU - Greene, Mark H AD - Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA koehlyl@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 812 EP - 821 PB - John Wiley, Chichester UK VL - 17 IS - 8 SN - 1057-9249, 1057-9249 KW - Sisters KW - Ovarian cancer KW - Social support KW - Psychological distress KW - Breast cancer KW - Coping KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57263658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Sisters+in+hereditary+breast+and+ovarian+cancer+families%3A+communal+coping%2C+social+integration%2C+and+psychological+well-being&rft.au=Koehly%2C+Laura+M%3BPeters%2C+June+A%3BKuhn%2C+Natalia%3BHoskins%2C+Lindsey%3BLetocha%2C+Anne%3BKenen%2C+Regina%3BLoud%2C+Jennifer%3BGreene%2C+Mark+H&rft.aulast=Koehly&rft.aufirst=Laura&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1373 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Social support; Ovarian cancer; Coping; Sisters; Breast cancer; Psychological distress DO - http://dx.doi.org/10.1002/pon.1373 ER - TY - JOUR T1 - Of Mice and Mentors Developing Cyber-Infrastructure to Support Transdisciplinary Scientific Collaboration AN - 57263145; 200821728 AB - Describes a "cybersystems" approach to scientific knowledge & practice via the example of how the computer mouse, hypertext, & computer-supported cooperative work environments were pioneered by Douglas Engelbart & his colleagues at the Stanford Research Instit & in Silicon Valley (CA) in the early 1960s. The applicability of such transdisciplinary scientific teamwork & cooperation to the health sciences is discussed; the example of the National Cancer Instit's adoption of "grid computing" is provided. Specific guidelines for making "cyberinfrastructure" more useful are offered. References. K. Hyatt Stewart [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Hesse, Bradford W AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland hesseb@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - S235 EP - S239 PB - Elsevier Science, New York NY VL - 35 IS - 2S1 SN - 0749-3797, 0749-3797 KW - Interdisciplinary team work KW - Scientific research KW - Systems approach KW - Cyberspace KW - Computerized information systems KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57263145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Of+Mice+and+Mentors+Developing+Cyber-Infrastructure+to+Support+Transdisciplinary+Scientific+Collaboration&rft.au=Hesse%2C+Bradford+W&rft.aulast=Hesse&rft.aufirst=Bradford&rft.date=2008-08-01&rft.volume=35&rft.issue=2S1&rft.spage=S235&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.05.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Interdisciplinary team work; Systems approach; Computerized information systems; Scientific research; Cyberspace DO - http://dx.doi.org/10.1016/j.amepre.2008.05.011 ER - TY - JOUR T1 - Psychological distress and quality of life associated with genetic testing for breast cancer risk AN - 57261076; 200822708 AB - This study investigated short- and long-term psychological outcomes associated with BRCA1/2 genetic testing in women with a personal or family history of breast cancer. Participants included 126 women considering genetic testing. Questionnaires were administered prior to testing, one week, three and six months after result disclosure. Results indicated no systematic effects of testing based on personal cancer history. Mutation carriers and women who elected not to be tested reported greater perceived risk and intrusive and avoidant thoughts at follow-up time points than did women who received negative (uninformative) or variant results. Mutation carriers reported more distress at the three-month follow-up but by six months the effects of test result on distress dissipated and groups were comparable. Cluster analyses identified two groups of individuals based on distress at baseline; these groups were used to predict psychological outcomes after testing. Distress remained constant in both groups: those who were high at baseline remained high and those who were low remained low. Test results did not moderate this effect. Results suggest that genetic testing for BRCA1/2 does not increase distress or have deleterious effects on quality of life over the long term. However, sub-groups of women may report more distress over time. These data indicate the need for more targeted counseling to individuals who report high levels of distress when considering genetic testing. [Copyright 2007 John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Smith, Ashley Wilder AU - Dougall, Angela Liegey AU - Posluszny, Donna M AU - Somers, Tamara J AU - Rubinstein, Wendy S AU - Baum, Andrew AD - Division of Cancer Prevention and the Applied Research Program of the Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA smithas@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 767 EP - 773 PB - John Wiley, Chichester UK VL - 17 IS - 8 SN - 1057-9249, 1057-9249 KW - Carriers KW - Women KW - Psychological distress KW - Breast cancer KW - Genetic screening KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57261076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Psychological+distress+and+quality+of+life+associated+with+genetic+testing+for+breast+cancer+risk&rft.au=Smith%2C+Ashley+Wilder%3BDougall%2C+Angela+Liegey%3BPosluszny%2C+Donna+M%3BSomers%2C+Tamara+J%3BRubinstein%2C+Wendy+S%3BBaum%2C+Andrew&rft.aulast=Smith&rft.aufirst=Ashley&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1291 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Psychological distress; Women; Genetic screening; Quality of life; Breast cancer; Carriers DO - http://dx.doi.org/10.1002/pon.1291 ER - TY - JOUR T1 - Preventing unintentional pediatric injuries: a tailored intervention for parents and providers AN - 57258637; 200822276 AB - The purpose of this study was to determine the efficacy of providing (i) tailored injury prevention information (T-IPI) to parents and (ii) concurrent T-IPI to parents and providers to promote parent adoption of safety practices. During well-child visits, parents of children ages 4 and younger completed a computer assessment and were randomized to receive generic injury prevention information, T-IPI or T-IPI supplemented with a tailored summary for providers. Follow-up assessments were completed by telephone 1 month later. Parents receiving T-IPI alone or with supplementary provider information were more likely to report adopting a new injury prevention behavior than those receiving generic information (49 and 45%, respectively, compared with 32%; odds ratio = 2.0 and 1.9, respectively), and these effects were greatest among the least educated parents. In addition, more complicated behavior changes were reported by those receiving tailored information. Provider receipt of feedback did not result in significantly different provider-parent communication or change in parents' safety practices. Providing parents with individually tailored pediatric injury prevention information may be an effective method for delivering injury prevention anticipatory guidance. Tailoring may have particular utility for more complicated behaviors and for communication with less educated parents. Adapted from the source document. JF - Health Education Research AU - Nansel, Tonja R AU - Weaver, Nancy L AU - Jacobsen, Heather A AU - Glasheen, Cristie AU - Kreuter, Matthew W AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA nanselt@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 656 EP - 669 PB - Oxford University Press, UK VL - 23 IS - 4 SN - 0268-1153, 0268-1153 KW - Assessment KW - Paediatrics KW - Prevention KW - Injuries KW - Safety KW - Parents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57258637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+Research&rft.atitle=Preventing+unintentional+pediatric+injuries%3A+a+tailored+intervention+for+parents+and+providers&rft.au=Nansel%2C+Tonja+R%3BWeaver%2C+Nancy+L%3BJacobsen%2C+Heather+A%3BGlasheen%2C+Cristie%3BKreuter%2C+Matthew+W&rft.aulast=Nansel&rft.aufirst=Tonja&rft.date=2008-08-01&rft.volume=23&rft.issue=4&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Health+Education+Research&rft.issn=02681153&rft_id=info:doi/10.1093%2Fher%2Fcym041 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HRTPE2 N1 - SubjectsTermNotLitGenreText - Parents; Prevention; Injuries; Paediatrics; Safety; Assessment DO - http://dx.doi.org/10.1093/her/cym041 ER - TY - JOUR T1 - The Science of Team Science: Commentary on Measurements of Scientific Readiness AN - 57254910; 200821699 AB - Suggests that a necessary precursor to transdisciplinary team science is an evaluation of areas that are merging &/or ready for a collaborative approach. Specific elements in two distinct phases of such an evaluation for readiness are outlined. References. K. Hyatt Stewart [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Hays, Timothy C AD - Office of Portfolio Analysis and Strategic Initiatives, NIH, Bethesda, Maryland thays@od.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - S193 EP - S195 PB - Elsevier Science, New York NY VL - 35 IS - 2S1 SN - 0749-3797, 0749-3797 KW - Evaluation KW - Interdisciplinary team work KW - Scientific research KW - Collaborative approach KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57254910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=The+Science+of+Team+Science%3A+Commentary+on+Measurements+of+Scientific+Readiness&rft.au=Hays%2C+Timothy+C&rft.aulast=Hays&rft.aufirst=Timothy&rft.date=2008-08-01&rft.volume=35&rft.issue=2S1&rft.spage=S193&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.05.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Collaborative approach; Interdisciplinary team work; Scientific research; Evaluation DO - http://dx.doi.org/10.1016/j.amepre.2008.05.016 ER - TY - JOUR T1 - The Collaboration Readiness of Transdisciplinary Research Teams and Centers Findings from the National Cancer Institute's TREC Year-One Evaluation Study AN - 57250512; 200821644 AB - Growing interest in promoting cross-disciplinary collaboration among health scientists has prompted several federal agencies, including the NIH, to establish large, multicenter initiatives intended to foster collaborative research & training. In order to assess whether these initiatives are effective in promoting scientific collaboration that ultimately results in public health improvements, it is necessary to develop new strategies for evaluating research processes & products as well as the longer-term societal outcomes associated with these programs. Ideally, evaluative measures should be administered over the entire course of large initiatives, including their near-term & later phases. The present study focuses on the development of new tools for assessing the readiness for collaboration among health scientists at the outset (during the first year) of their participation in the National Cancer Institute's Transdisciplinary Research on Energetics & Cancer (TREC) initiative. Indexes of collaborative readiness, along with additional measures of near-term collaborative processes, were administered as part of the TREC Year-One evaluation survey. Additionally, early progress toward scientific collaboration & integration was assessed, using a protocol for evaluating written research products. Results from the Year-One survey & the ratings of written products provide evidence of cross-disciplinary collaboration among participants during the first year of the initiative, & also reveal opportunities for enhancing collaborative processes & outcomes during subsequent phases of the project. The implications of these findings for future evaluations of team science initiatives are discussed. [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Hall, Kara L AU - Stokols, Daniel AU - Moser, Richard P AU - Taylor, Brandie K AU - Thornquist, Mark D AU - Nebeling, Linda C AU - Ehret, Carolyn C AU - Barnett, Matthew J AU - McTiernan, Anne AU - Berger, Nathan A AU - Goran, Michael I AU - Jeffery, Robert W AD - Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland hallka@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - S161 EP - S172 PB - Elsevier Science, New York NY VL - 35 IS - 2S1 SN - 0749-3797, 0749-3797 KW - Interdisciplinary team work KW - Scientific research KW - Measures KW - Evaluative processes KW - Public health KW - Interagency collaboration KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=The+Collaboration+Readiness+of+Transdisciplinary+Research+Teams+and+Centers+Findings+from+the+National+Cancer+Institute%27s+TREC+Year-One+Evaluation+Study&rft.au=Hall%2C+Kara+L%3BStokols%2C+Daniel%3BMoser%2C+Richard+P%3BTaylor%2C+Brandie+K%3BThornquist%2C+Mark+D%3BNebeling%2C+Linda+C%3BEhret%2C+Carolyn+C%3BBarnett%2C+Matthew+J%3BMcTiernan%2C+Anne%3BBerger%2C+Nathan+A%3BGoran%2C+Michael+I%3BJeffery%2C+Robert+W&rft.aulast=Hall&rft.aufirst=Kara&rft.date=2008-08-01&rft.volume=35&rft.issue=2S1&rft.spage=S161&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.03.035 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Interagency collaboration; Public health; Evaluative processes; Measures; Interdisciplinary team work; Scientific research DO - http://dx.doi.org/10.1016/j.amepre.2008.03.035 ER - TY - JOUR T1 - Moving the Science of Team Science Forward: Collaboration and Creativity AN - 57250489; 200821643 AB - Teams of scientists representing diverse disciplines are often brought together for purposes of better understanding &, ultimately, resolving urgent public health & environmental problems. Likewise, the emerging field of the science of team science draws on diverse disciplinary perspectives to better understand & enhance the processes & outcomes of scientific collaboration. In this supplement to the American Journal of Preventive Medicine, leading scholars in the nascent field of team science have come together with a common goal of advancing the field with new models, methods, & measures. This summary article highlights key themes reflected in the supplement & identifies several promising directions for future research organized around the following broad challenges: (1) operationalizing cross-disciplinary team science & training more clearly; (2) conceptualizing the multiple dimensions of readiness for team science; (3) ensuring the sustainability of transdisciplinary team science; (4) developing more effective models & strategies for training transdisciplinary scientists; (5) creating & validating improved models, methods, & measures for evaluating team science; & (6) fostering transdisciplinary cross-sector partnerships. A call to action is made to leaders from the research, funding, & practice sectors to embrace strategies of creativity & innovation in a collective effort to move the field forward, which may not only advance the science of team science but, ultimately, public health science & practice. [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Hall, Kara L AU - Feng, Annie X AU - Moser, Richard P AU - Stokols, Daniel AU - Taylor, Brandie K AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland hallka@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - S243 EP - S249 PB - Elsevier Science, New York NY VL - 35 IS - 2S1 SN - 0749-3797, 0749-3797 KW - Interdisciplinary team work KW - Scientific research KW - Research partnerships KW - Environmental health KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Moving+the+Science+of+Team+Science+Forward%3A+Collaboration+and+Creativity&rft.au=Hall%2C+Kara+L%3BFeng%2C+Annie+X%3BMoser%2C+Richard+P%3BStokols%2C+Daniel%3BTaylor%2C+Brandie+K&rft.aulast=Hall&rft.aufirst=Kara&rft.date=2008-08-01&rft.volume=35&rft.issue=2S1&rft.spage=S243&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.05.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Interdisciplinary team work; Public health; Scientific research; Environmental health; Research partnerships DO - http://dx.doi.org/10.1016/j.amepre.2008.05.007 ER - TY - JOUR T1 - Projections of the costs associated with colorectal cancer care in the United States, 2000-2020 AN - 57249537; 200823074 AB - Because of aging trends in the US, the number of prevalent colorectal cancer patients is expected to increase. We projected economic burden to the Medicare program and its beneficiaries through the year 2020. Burden was estimated for the initial phase of care, the period following diagnosis, the last year of life, and the continuing phase. Projected burden was evaluated with varying assumptions about incidence, survival, and costs of care. Estimated costs of care in 2000 in the initial, continuing, and last year of life phases of care were approximately $3.18 billion, $1.68 billion, and $2.63 billion, respectively. By the year 2020 under the fixed current incidence, survival, and cost scenario, projected costs for the initial, continuing, and last year of life phases were $4.75 billion, $2.63 billion, and $4.05 billion. Under the current trends scenario (decreasing incidence, improving survival, and increasing costs), costs were $5.19 billion, $3.57 billion, and $5.27 billion. By the year 2020, estimated costs of colorectal cancer care among individuals aged 65 and older increased by 53% in the fixed scenario and by 89% in the current trends scenario. The future economic burden of colorectal cancer to the Medicare program and its beneficiaries in the US will be substantial. [Copyright 2007 John Wiley and Sons, Ltd.] JF - Health Economics AU - Yabroff, K Robin AU - Mariotto, Angela B AU - Feuer, Eric AU - Brown, Martin L AD - Health Services and Economics Branch/Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA yabroffr@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 947 EP - 959 PB - John Wiley, Chichester UK VL - 17 IS - 8 SN - 1057-9230, 1057-9230 KW - Costs KW - Medicare KW - Colorectal cancer KW - Beneficiaries KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57249537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Projections+of+the+costs+associated+with+colorectal+cancer+care+in+the+United+States%2C+2000-2020&rft.au=Yabroff%2C+K+Robin%3BMariotto%2C+Angela+B%3BFeuer%2C+Eric%3BBrown%2C+Martin+L&rft.aulast=Yabroff&rft.aufirst=K&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1307 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Colorectal cancer; Costs; Beneficiaries; Medicare; Prevalence DO - http://dx.doi.org/10.1002/hec.1307 ER - TY - JOUR T1 - The Role of Health Insurance Coverage in Cancer Screening Utilization AN - 57238977; 200822542 AB - Introduction. Although previous studies have shown a correlation between health insurance coverage and cancer screening, underinsurance and cancer screening among racial/ethnic minorities has not been examined. Methods. Data from the 2000 and 2003 National Health Interview Surveys are used in this analysis. Cross-tabulations, age, and racial/ethnic group stratified regression analyses are used to examine associations between health insurance status and receipt of mammography, Pap testing, prostate specific antigen tests, fecal occult blood test (FOBT) and colorectal endoscopy. Results. In overall models, uninsurance was associated with lower receipt of all tests except FOBT among participants ages 65-85 years. Underinsurance was associated with lower receipt of mammography among women under 65 years only. Conclusion. These findings show age variation in the association between cancer screening and health insurance coverage. In addition, health insurance appears to act similarly across racial/ethnic groups. Further examination of underinsurance in cancer screening utilization and other health behaviors is needed. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Robinson, JaMuir M AU - Shavers, Vickie AD - Cancer Prevention and Fellowship Program, Division of Cancer Prevention and Office of Education and Special Initiatives, National Cancer Institute (NCI), 6116 Executive Blvd., Ste. 202, Bethesda, MD 20892 Tel: (301) 496-9724 Y1 - 2008/08// PY - 2008 DA - August 2008 SP - 842 EP - 856 PB - John Hopkins University Press, Baltimore MD VL - 19 IS - 3 SN - 1049-2089, 1049-2089 KW - Cancer screening, race, ethnicity, health insurance, underinsurance, health services KW - Screening KW - Racial differences KW - Coverage KW - Health insurance KW - Ethnic groups KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57238977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=The+Role+of+Health+Insurance+Coverage+in+Cancer+Screening+Utilization&rft.au=Robinson%2C+JaMuir+M%3BShavers%2C+Vickie&rft.aulast=Robinson&rft.aufirst=JaMuir&rft.date=2008-08-01&rft.volume=19&rft.issue=3&rft.spage=842&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Health insurance; Screening; Cancer; Coverage; Racial differences; Ethnic groups ER - TY - JOUR T1 - Guidelines for research on drugged driving AN - 36940160; 3756137 AB - Aim A major problem in assessing the true public health impact of drug-use on driving and overall traffic safety is that the variables being measured across studies vary significantly. In studies reported in a growing global literature, basic parameters assessed, analytical techniques and drugs tested are simply not comparable due to lack of standardization in the field. These shortcomings severely limit the value of this research to add knowledge to the field. A set of standards to harmonize research findings is sorely needed. This project was initiated by several international organizations to develop guidelines for research on drugged driving. Methods A September 2006 meeting of international experts discussed the harmonization of protocols for future research on drugged driving. The principal objective of the meeting was to develop a consensus report setting guidelines, standards, core data variables and other controls that would form the basis for future international research. A modified Delphi method was utilized to develop draft guidelines. Subsequently, these draft guidelines were posted on the internet for global review, and comments received were integrated into the final document. Results The Guidelines Document is divided into three major sections, each focusing upon different aspects of drugged driving research (e.g. roadside surveys, prevalence studies, hospital studies, fatality and crash investigations, etc.) within the critical issue areas of 'behavior', 'epidemiology' and 'toxicology'. The behavioral section contains 32 specific recommendations; (2) epidemiology 40 recommendations; and (3) toxicology 64 recommendations. Conclusions It is anticipated that these guidelines will improve significantly the overall quality of drugged driving research and facilitate future cross-study comparisons nationally and globally. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Walsh, J Michael AU - Verstraete, Alain G AU - Huestis, Marilyn A AU - Mørland, Jørg AD - Ghent University ; US National Institute on Drug Abuse ; Norwegian Institute of Public Health Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1258 EP - 1268 VL - 103 IS - 8 SN - 0965-2140, 0965-2140 KW - Sociology KW - Drink-driving KW - Research methods KW - Drug addicts KW - Social problems KW - Road accidents KW - Road transport KW - Addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36940160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Guidelines+for+research+on+drugged+driving&rft.au=Walsh%2C+J+Michael%3BVerstraete%2C+Alain+G%3BHuestis%2C+Marilyn+A%3BM%C3%B8rland%2C+J%C3%B8rg&rft.aulast=Walsh&rft.aufirst=J&rft.date=2008-08-01&rft.volume=103&rft.issue=8&rft.spage=1258&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02277.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 561 6220; 11893 11979; 10919; 11086 12937; 3745 562; 3734 1121 11776; 11080 524 DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02277.x ER - TY - JOUR T1 - Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease AN - 222636455; 18587394 AB - Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development. [PUBLICATION ABSTRACT] JF - Nature Genetics AU - Nicolae, Dan L AU - Cho, Judy H AU - Duerr, Richard H AU - Rioux, John D AU - Brant, Steven R AU - Silverberg, Mark S AU - Taylor, Kent D AU - Barmada, M Michael AU - Bitton, Alain AU - Dassopoulos, Themistocles AU - Datta, Lisa Wu AU - Green, Todd AU - Griffiths, Anne M AU - Kistner, Emily O AU - Murtha, Michael T AU - Regueiro, Miguel D AU - Rotter, Jerome I AU - Schumm, L Philip AU - Steinhart, A Hillary AU - Targan, Stephan R AU - Xavier, Ramnik J AU - Libioulle, Cécile AU - Sandor, Cynthia AU - Lathrop, Mark AU - Belaiche, Jacques AU - Dewit, Olivier AU - Gut, Ivo AU - Heath, Simon AU - Laukens, Debby AU - Mni, Myriam AU - Rutgeerts, Paul AU - Van Gossum, André AU - Zelenika, Diana AU - Franchimont, Denis AU - Hugot, Jean-Pierre AU - de Vos, Martine AU - Vermeire, Severine AU - Louis, Edouard AU - Cardon, Lon R AU - Anderson, Carl A AU - Drummond, Hazel AU - Nimmo, Elaine AU - Ahmad, Tariq AU - Prescott, Natalie J AU - Onnie, Clive M AU - Fisher, Sheila A AU - Marchini, Jonathan AU - Ghori, Jilur AU - Bumpstead, Suzannah AU - Gwilliam, Rhian AU - Tremelling, Mark AU - Deloukas, Panos AU - Mansfield, John AU - Jewell, Derek AU - Satsangi, Jack AU - Mathew, Christopher G AU - Parkes, Miles AU - Georges, Michel AU - Daly, Mark J Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 955 EP - 62 CY - New York PB - Nature Publishing Group VL - 40 IS - 8 SN - 10614036 KW - Biology--Genetics KW - Inflammatory bowel disease KW - Medical research KW - Studies KW - Genetics KW - Genomics KW - Crohns disease KW - Humans KW - Genome, Human KW - Quantitative Trait Loci KW - Crohn Disease -- genetics KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/222636455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=Genome-wide+association+defines+more+than+30+distinct+susceptibility+loci+for+Crohn%27s+disease&rft.au=Nicolae%2C+Dan+L%3BCho%2C+Judy+H%3BDuerr%2C+Richard+H%3BRioux%2C+John+D%3BBrant%2C+Steven+R%3BSilverberg%2C+Mark+S%3BTaylor%2C+Kent+D%3BBarmada%2C+M+Michael%3BBitton%2C+Alain%3BDassopoulos%2C+Themistocles%3BDatta%2C+Lisa+Wu%3BGreen%2C+Todd%3BGriffiths%2C+Anne+M%3BKistner%2C+Emily+O%3BMurtha%2C+Michael+T%3BRegueiro%2C+Miguel+D%3BRotter%2C+Jerome+I%3BSchumm%2C+L+Philip%3BSteinhart%2C+A+Hillary%3BTargan%2C+Stephan+R%3BXavier%2C+Ramnik+J%3BLibioulle%2C+C%C3%A9cile%3BSandor%2C+Cynthia%3BLathrop%2C+Mark%3BBelaiche%2C+Jacques%3BDewit%2C+Olivier%3BGut%2C+Ivo%3BHeath%2C+Simon%3BLaukens%2C+Debby%3BMni%2C+Myriam%3BRutgeerts%2C+Paul%3BVan+Gossum%2C+Andr%C3%A9%3BZelenika%2C+Diana%3BFranchimont%2C+Denis%3BHugot%2C+Jean-Pierre%3Bde+Vos%2C+Martine%3BVermeire%2C+Severine%3BLouis%2C+Edouard%3BCardon%2C+Lon+R%3BAnderson%2C+Carl+A%3BDrummond%2C+Hazel%3BNimmo%2C+Elaine%3BAhmad%2C+Tariq%3BPrescott%2C+Natalie+J%3BOnnie%2C+Clive+M%3BFisher%2C+Sheila+A%3BMarchini%2C+Jonathan%3BGhori%2C+Jilur%3BBumpstead%2C+Suzannah%3BGwilliam%2C+Rhian%3BTremelling%2C+Mark%3BDeloukas%2C+Panos%3BMansfield%2C+John%3BJewell%2C+Derek%3BSatsangi%2C+Jack%3BMathew%2C+Christopher+G%3BParkes%2C+Miles%3BGeorges%2C+Michel%3BDaly%2C+Mark+J&rft.aulast=Nicolae&rft.aufirst=Dan&rft.date=2008-08-01&rft.volume=40&rft.issue=8&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=Nature+Genetics&rft.issn=10614036&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Aug 2008 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2014-09-25 ER - TY - JOUR T1 - Importance of Leukoaraiosis on CT for Tissue Plasminogen Activator Decision Making: Evaluation of the NINDS rt-PA Stroke Study AN - 221232278; 18560214 AB - Background: Leukoaraiosis is associated with microhemorrhages on T2*-weighted magnetic resonance imaging of the brain. Such hemorrhages have been postulated to be responsible for symptomatic intracerebral hemorrhage (ICH) after thrombolytic treatment. We examined the relationship between small-vessel ischemic disease and symptomatic ICH within the NINDS rt-PA Stroke Study. Methods: Baseline CT scans from the NINDS rt-PA Stroke Study were re-evaluated retrospectively by blinded expert CT readers using the van Swieten Score (vSS) for leukoaraiosis. The scale examined the severity of white-matter changes on 3 serial CT slices and graded separately for the 2 distinct regionsanterior and posterior to the central sulcus: 0 = no lesion, 1 = partlyinvolving the white matter, and 2 = extending up to the cortex. Results: 603 CT scans were interpreted. The risk of symptomatic ICH increased with higher vSS in both the placebo and treatment groups. The absolute risk of symptomatic hemorrhage was 7.9% in the rt-PA-treated cohort among patients with severe white-matter disease (vSS = 3-4) versus 2.9% receiving placebo. Among severe leukoaraiosis patients (vSS = 3-4), no differential treatment effect was seen with rt-PA patients achieving better outcomes than placebo, modified Rankin score 0-1 in 31.6% of rt-PA-treated versus 14.7% of placebo-treated patients. Conclusion: The results from the present study do not support the concept that leukoaraiosis present on baseline noncontrast CT scanning is critical to thrombolysis decision making in the first 3 h from symptom onset. No clear leukoaraiosis threshold was identified below which no benefit or harm could be seen from intravenous rt-PA therapy. Copyright © 2008 S. Karger AG, Basel [PUBLICATION ABSTRACT] JF - Cerebrovascular Diseases AU - Demchuk, Andrew M AU - Khan, Firosh AU - Hill, Michael D AU - Barber, Philip A AU - Silver, Brian AU - Patel, Suresh AU - Levine, Steven R Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 120 EP - 5 CY - Basel PB - S. Karger AG VL - 26 IS - 2 SN - 10159770 KW - Medical Sciences KW - Fibrinolytic Agents KW - Recombinant Proteins KW - Tissue Plasminogen Activator KW - Severity of Illness Index KW - Multicenter Studies as Topic KW - Randomized Controlled Trials as Topic KW - Infusions, Intravenous KW - Humans KW - Fibrinolytic Agents -- adverse effects KW - Retrospective Studies KW - Decision Making KW - Patient Selection KW - Risk Assessment KW - Logistic Models KW - Stroke -- radiography KW - Treatment Outcome KW - Tissue Plasminogen Activator -- adverse effects KW - Leukoaraiosis -- complications KW - Time Factors KW - Recombinant Proteins -- administration & dosage KW - Stroke -- drug therapy KW - Leukoaraiosis -- radiography KW - Fibrinolytic Agents -- administration & dosage KW - Tomography, X-Ray Computed KW - Intracranial Hemorrhages -- etiology KW - Thrombolytic Therapy -- adverse effects KW - Tissue Plasminogen Activator -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/221232278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cerebrovascular+Diseases&rft.atitle=Importance+of+Leukoaraiosis+on+CT+for+Tissue+Plasminogen+Activator+Decision+Making%3A+Evaluation+of+the+NINDS+rt-PA+Stroke+Study&rft.au=Demchuk%2C+Andrew+M%3BKhan%2C+Firosh%3BHill%2C+Michael+D%3BBarber%2C+Philip+A%3BSilver%2C+Brian%3BPatel%2C+Suresh%3BLevine%2C+Steven+R&rft.aulast=Demchuk&rft.aufirst=Andrew&rft.date=2008-08-01&rft.volume=26&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Cerebrovascular+Diseases&rft.issn=10159770&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright (c) 2008 S. Karger AG, Basel N1 - Last updated - 2016-11-12 ER - TY - JOUR T1 - Complex Regulation of the DnaJ Homolog CbpA by the Global Regulators S and Lrp, by the Specific Inhibitor CbpM, and by the Proteolytic Degradation of CbpM , AN - 21483707; 12495727 AB - CbpA is a DnaJ homolog that functions as a DnaK cochaperone. Several cellular processes, including growth at low and high temperatures and septum formation during cell division, require either CbpA or DnaJ. CbpA is encoded in an operon with the gene for CbpM, which is a specific in vivo and in vitro inhibitor of CbpA. Here, we have cooverexpressed CbpA with CbpM in a cbpAM dnaJ strain and examined the resulting phenotypes. Under these conditions, sufficient free CbpA activity was present to support growth at low temperatures, but not at high temperatures. Defects in cell division and in replication were also partially complemented by CbpA when cooverexpressed with CbpM. Utilizing reporter fusions, we demonstrated that the cbpAM operon was maximally transcribed at the transition from exponential growth to stationary phase. Transcription was controlled by the S and Lrp global regulators, and both leucine availability and growth temperature influenced transcription. CbpA and CbpM accumulated to similar levels in stationary phase, 2,300 monomers per cell. When not bound to CbpA, CbpM was unstable and was degraded by the Lon and ClpAP proteases. These data demonstrate that CbpA activity is controlled at multiple levels. JF - Journal of Bacteriology AU - Chenoweth, Matthew R AU - Wickner, Sue AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, WicknerS@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 5153 EP - 5161 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 190 IS - 15 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Proteolysis KW - Temperature effects KW - Data processing KW - Replication KW - Temperature requirements KW - Transcription KW - Monomers KW - stationary phase KW - Cell division KW - DnaK protein KW - Leucine KW - Proteinase KW - Septum KW - Operons KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21483707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Complex+Regulation+of+the+DnaJ+Homolog+CbpA+by+the+Global+Regulators+S+and+Lrp%2C+by+the+Specific+Inhibitor+CbpM%2C+and+by+the+Proteolytic+Degradation+of+CbpM+%2C&rft.au=Chenoweth%2C+Matthew+R%3BWickner%2C+Sue&rft.aulast=Chenoweth&rft.aufirst=Matthew&rft.date=2008-08-01&rft.volume=190&rft.issue=15&rft.spage=5153&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00437-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Temperature effects; Proteolysis; Data processing; Replication; Temperature requirements; Transcription; stationary phase; Monomers; Cell division; DnaK protein; Leucine; Proteinase; Septum; Operons DO - http://dx.doi.org/10.1128/JB.00437-08 ER - TY - JOUR T1 - Personality Predictoro of Longevity: Activity, Emotional Stability, and Conscientiousness AN - 21220561; 11273656 AB - Objective: To examine the association between personality traits and longevity. Methods: Using the Guilford-Zimmerman Temperament Survey, personality traits were assessed in 2359 participants (38% women; age = 17 to 98 years, mean = 50 years) from the Baltimore Longitudinal Study of Aging, starting in 1958. Over the duration of the study, 943 (40%) participants died, on average 18 years after their personality assessment. The association of each trait with longevity was examined by Cox regression controlling for demographic variables. Results: In preliminary analyses among the deceased, those who scored 1 standard deviation (SD) above the mean on General Activity (a facet of Extraversion), Emotional Stability (low Neuroticism), or Conscientiousness lived on average 2 to 3 years longer than those scoring 1 SD below the mean. Survival analyses on the full sample confirmed the association of General Activity, Emotional Stability, and Conscientiousness with lower risk of death, such that every 1-SD increase was related to about 13%, 15%, and 27% risk reduction, respectively. The association of personality traits with longevity was largely independent from the influence of smoking and obesity. Personality predictors of longevity did not differ by sex, except for Ascendance (a facet of Extraversion). Emotional Stability was a significant predictor when the analyses were limited to deaths due to cardiovascular disease, with comparable effect sizes for General Activity and Conscientiousness. Conclusions: In a large sample of generally healthy individuals followed for almost five decades, longevity was associated with being conscientious, emotionally stable, and active. JF - Psychosomatic Medicine AU - Terracciano, A AU - Loeckenhoff, CE AU - Zonderman, AB AU - Ferrucci, L AU - Costa, PT Jr AD - Laboratory of Personality and Cognition, National Institute on Aging, NIH, DHHS, 251 Bayview Blvd, Baltimore, MD 21224, USA, TerraccianoA@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 621 EP - 627 VL - 70 IS - 6 SN - 0033-3174, 0033-3174 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - demography KW - Emotions KW - Age KW - Aging KW - obesity KW - Personality KW - Survival KW - USA, Maryland, Baltimore KW - personality KW - Demography KW - risk reduction KW - Smoking KW - Risk factors KW - longevity KW - aging KW - Sex KW - Mortality KW - Obesity KW - Neurosis KW - Longevity KW - Standard deviation KW - Cardiovascular diseases KW - survival KW - longitudinal studies KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21220561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+Medicine&rft.atitle=Personality+Predictoro+of+Longevity%3A+Activity%2C+Emotional+Stability%2C+and+Conscientiousness&rft.au=Terracciano%2C+A%3BLoeckenhoff%2C+CE%3BZonderman%2C+AB%3BFerrucci%2C+L%3BCosta%2C+PT+Jr&rft.aulast=Terracciano&rft.aufirst=A&rft.date=2008-08-01&rft.volume=70&rft.issue=6&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+Medicine&rft.issn=00333174&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Emotions; Obesity; Aging; Personality; Neurosis; Survival; Longevity; Demography; Smoking; Standard deviation; Risk factors; Cardiovascular diseases; Sex; demography; risk reduction; Mortality; Age; obesity; survival; longevity; personality; longitudinal studies; aging; USA, Maryland, Baltimore ER - TY - JOUR T1 - A Cell-Based PDE4 Assay in 1536-Well Plate Format for High-Throughput Screening AN - 21201105; 11621765 AB - The cyclic nucleotide phosphodiesterases (PDEs) are intracellular enzymes that catalyze the hydrolysis of 3,'5'-cyclic nucleotides, such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), to their corresponding 5'nucleotide monophosphates. These enzymes play an important role in controlling cellular concentrations of cyclic nucleotides and thus regulate a variety of cellular signaling events. PDEs are emerging as drug targets for several diseases, including asthma, cardiovascular disease, attention-deficit hyperactivity disorder, Parkinson's disease, and Alzheimer's disease. Although biochemical assays with purified recombinant PDE enzymes and cAMP or cGMP substrate are commonly used for compound screening, cell-based assays would provide a better assessment of compound activity in a more physiological context. The authors report the development and validation of a new cell-based PDE4 assay using a constitutively active G-protein-coupled receptor as a driving force for cAMP production and a cyclic nucleotide-gated cation channel as a biosensor in 1536-well plates. (Journal of Biomolecular Screening 2008:609-618) JF - Journal of Biomolecular Screening AU - Titus, Steven A AU - Li, Xiao AU - Southall, Noel AU - Lu, Jianming AU - Inglese, James AU - Brasch, Michael AU - Austin, Christopher P AU - Zheng, Wei AD - NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, Bethesda, Maryland Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 609 EP - 618 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 13 IS - 7 SN - 1087-0571, 1087-0571 KW - Biotechnology and Bioengineering Abstracts KW - cation channels KW - double prime G protein-coupled receptors KW - Parkinson's disease KW - Attention deficit hyperactivity disorder KW - Cyclic AMP KW - Alzheimer's disease KW - Cyclic nucleotides KW - Asthma KW - Enzymes KW - Drug development KW - Hydrolysis KW - Nucleotides KW - Biosensors KW - Cyclic GMP KW - Neurodegenerative diseases KW - Movement disorders KW - 3',5'-Cyclic-nucleotide phosphodiesterase KW - high-throughput screening KW - Cardiovascular diseases KW - phosphodiesterase KW - Signal transduction KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21201105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=A+Cell-Based+PDE4+Assay+in+1536-Well+Plate+Format+for+High-Throughput+Screening&rft.au=Titus%2C+Steven+A%3BLi%2C+Xiao%3BSouthall%2C+Noel%3BLu%2C+Jianming%3BInglese%2C+James%3BBrasch%2C+Michael%3BAustin%2C+Christopher+P%3BZheng%2C+Wei&rft.aulast=Titus&rft.aufirst=Steven&rft.date=2008-08-01&rft.volume=13&rft.issue=7&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057108319977 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - cation channels; double prime G protein-coupled receptors; Parkinson's disease; Alzheimer's disease; Cyclic AMP; Attention deficit hyperactivity disorder; Enzymes; Asthma; Cyclic nucleotides; Drug development; Hydrolysis; Nucleotides; Cyclic GMP; Biosensors; Neurodegenerative diseases; Movement disorders; 3',5'-Cyclic-nucleotide phosphodiesterase; high-throughput screening; Cardiovascular diseases; phosphodiesterase; Signal transduction DO - http://dx.doi.org/10.1177/1087057108319977 ER - TY - JOUR T1 - Testing for Group Effect in a 2 X k Heteroscedastic ANOVA Model AN - 21121938; 11158231 AB - It is natural to want to relax the assumption of homoscedasticity and Gaussian error in ANOVA models. For a two-way ANOVA model with 2 X k cells, one can derive tests of main effect for the factor with two levels (referred to as group) without assuming homoscedasticity or Gaussian error. Empirical likelihood can be used to derive testing procedures. An approximate empirical likelihood ratio test (AELRT) is derived for the test of group main effect. To approximate the distributions of the test statistics under the null hypothesis, simulation from the approximate empirical maximum likelihood estimate (AEMLE) restricted by the null hypothesis is used. The homoscedastic ANOVA F -test and a Box-type approximation to the distribution of the heteroscedastic ANOVA F -test are compared to the AELRT in level and power. The AELRT procedure is shown by simulation to have appropriate type I error control (although possibly conservative) when the distribution of the test statistics are approximated by simulation from the constrained AEMLE. The methodology is motivated and illustrated by an analysis of folate levels in the blood among two alcohol intake groups while accounting for gender. JF - Biometrical Journal AU - Troendle, James F AD - Biometry and Mathematical Statistics Branch, National Institute of Child Health and Human Development, Bld 6100, Bethesda, MD 20892, USA, jt3t@nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 571 EP - 583 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Blood KW - Statistics KW - Alcoholic beverages KW - Statistical analysis KW - Biometrics KW - Folic acid KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21121938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Testing+for+Group+Effect+in+a+2+X+k+Heteroscedastic+ANOVA+Model&rft.au=Troendle%2C+James+F&rft.aulast=Troendle&rft.aufirst=James&rft.date=2008-08-01&rft.volume=50&rft.issue=4&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200710437 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Statistical analysis; Alcoholic beverages; Biometrics; Blood; Statistics; Folic acid DO - http://dx.doi.org/10.1002/bimj.200710437 ER - TY - JOUR T1 - A Model Free Approach to Combining Biomarkers AN - 21073878; 11133037 AB - For most diseases, single biomarkers do not have adequate sensitivity or specificity for practical purposes. We present an approach to combine several biomarkers into a composite marker score without assuming a model for the distribution of the predictors. Using sufficient dimension reduction techniques, we replace the original markers with a lower-dimensional version, obtained through linear transformations of markers that contain sufficient information for regression of the predictors on the outcome. We combine the linear transformations using their asymptotic properties into a scalar diagnostic score via the likelihood ratio statistic. The performance of this score is assessed by the area under the receiver-operator characteristics curve (ROC), a popular summary measure of the discriminatory ability of a single continuous diagnostic marker for binary disease outcomes. An asymptotic chi-squared test for assessing individual biomarker contribution to the diagnostic score is also derived. JF - Biometrical Journal AU - Pfeiffer, Ruth M AU - Bur, Efstathia AD - Biostatistics Branch, National Cancer Institute, 6120 Executive Blvd, EPS/8030, Bethesda, MD 20892, USA, pfeiffer@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 558 EP - 570 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Transformation KW - biomarkers KW - Models KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21073878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=A+Model+Free+Approach+to+Combining+Biomarkers&rft.au=Pfeiffer%2C+Ruth+M%3BBur%2C+Efstathia&rft.aulast=Pfeiffer&rft.aufirst=Ruth&rft.date=2008-08-01&rft.volume=50&rft.issue=4&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200710428 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - biomarkers; Transformation; Models DO - http://dx.doi.org/10.1002/bimj.200710428 ER - TY - JOUR T1 - Modeling the Violation of Reward Maximization and Invariance in Reinforcement Schedules AN - 21038838; 8517087 AB - It is often assumed that animals and people adjust their behavior to maximize reward acquisition. In visually cued reinforcement schedules, monkeys make errors in trials that are not immediately rewarded, despite having to repeat error trials. Here we show that error rates are typically smaller in trials equally distant from reward but belonging to longer schedules (referred to as 'schedule length effect'). This violates the principles of reward maximization and invariance and cannot be predicted by the standard methods of Reinforcement Learning, such as the method of temporal differences. We develop a heuristic model that accounts for all of the properties of the behavior in the reinforcement schedule task but whose predictions are not different from those of the standard temporal difference model in choice tasks. In the modification of temporal difference learning introduced here, the effect of schedule length emerges spontaneously from the sensitivity to the immediately preceding trial. We also introduce a policy for general Markov Decision Processes, where the decision made at each node is conditioned on the motivation to perform an instrumental action, and show that the application of our model to the reinforcement schedule task and the choice task are special cases of this general theoretical framework. Within this framework, Reinforcement Learning can approach contextual learning with the mixture of empirical findings and principled assumptions that seem to coexist in the best descriptions of animal behavior. As examples, we discuss two phenomena observed in humans that often derive from the violation of the principle of invariance: 'framing,' wherein equivalent options are treated differently depending on the context in which they are presented, and the 'sunk cost' effect, the greater tendency to continue an endeavor once an investment in money, effort, or time has been made. The schedule length effect might be a manifestation of these phenomena in monkeys. Author Summary Theories of rational behavior are built on a number of principles, including the assumption that subjects adjust their behavior to maximize their long-term returns and that they should work equally hard to obtain a reward in situations where the effort to obtain reward is the same (called the invariance principle). Humans, however, are sensitive to the manner in which equivalent choices are presented, or 'framed,' and often have a greater tendency to continue an endeavor once an investment in money, effort, or time has been made, a phenomenon known as 'sunk cost' effect. In a similar manner, when monkeys must perform different numbers of trials to obtain a reward, they work harder as the number of trials already performed increases, even though both the work remaining and the forthcoming reward are the same in all situations. Methods from the theory of Reinforcement Learning, which usually provide learning strategies aimed at maximizing returns, cannot model this violation of invariance. Here we generalize a prominent method of Reinforcement Learning so as to explain the violation of invariance, without losing the ability to model behaviors explained by standard Reinforcement Learning models. This generalization extends our understanding of how animals and humans learn and behave. JF - PLoS Computational Biology AU - La Camera, Giancarlo AU - Richmond, Barry J AU - Friston, Karl J AD - Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 4 IS - 8 SN - 1553-734X, 1553-734X KW - Biotechnology and Bioengineering Abstracts KW - Reinforcement schedules KW - Learning KW - Motivation KW - Reinforcement KW - Problem solving KW - Temporal discrimination learning KW - Computer applications KW - Nodes KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21038838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Computational+Biology&rft.atitle=Modeling+the+Violation+of+Reward+Maximization+and+Invariance+in+Reinforcement+Schedules&rft.au=La+Camera%2C+Giancarlo%3BRichmond%2C+Barry+J%3BFriston%2C+Karl+J&rft.aulast=La+Camera&rft.aufirst=Giancarlo&rft.date=2008-08-01&rft.volume=4&rft.issue=8&rft.spage=e1000131&rft.isbn=&rft.btitle=&rft.title=PLoS+Computational+Biology&rft.issn=1553734X&rft_id=info:doi/10.1371%2Fjournal.pcbi.1000131 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Reinforcement schedules; Learning; Motivation; Reinforcement; Problem solving; Nodes; Computer applications; Temporal discrimination learning; Models DO - http://dx.doi.org/10.1371/journal.pcbi.1000131 ER - TY - JOUR T1 - Fast block flow tracking of atrial septal defects in 4D echocardiography AN - 21026225; 8568433 AB - We are working to develop beating-heart atrial septal defect (ASD) closure techniques using real-time 3D ultrasound guidance. The major image processing challenges are the low-image quality and the processing of information at high-frame rate. This paper presents comparative results for ASD tracking in time sequences of 3D volumes of cardiac ultrasound. We introduce a block flow technique, which combines the velocity computation from optical flow for an entire block with template matching. Enforcing adapted similarity constraints to both the previous and first frames ensures optimal and unique solutions. We compare the performance of the proposed algorithm with that of block matching and region-based optical flow on eight in vivo 4D datasets acquired from porcine beating-heart procedures. Results show that our technique is more stable and has higher sensitivity than both optical flow and block matching in tracking ASDs. Computing velocity at the block level, our technique tracks ASD motion at 2 frames/s, much faster than optical flow and comparable in computation cost to block matching, and shows promise for real-time (30 frames/s). We report consistent results on clinical intra-operative images and retrieve the cardiac cycle (in ungated images) from error analysis. Quantitative results are evaluated on synthetic data with maximum tracking errors of 1 voxel. JF - Medical Image Analysis AU - Linguraru, Marius George AU - Vasilyev, Nikolay V AU - Marx, Gerald R AU - Tworetzky, Wayne AU - Del Nido, Pedro J AU - Howe, Robert D AD - Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA, lingurarum@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 397 EP - 412 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 12 IS - 4 SN - 1361-8415, 1361-8415 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Information processing KW - Echocardiography KW - Algorithms KW - Image processing KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21026225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Image+Analysis&rft.atitle=Fast+block+flow+tracking+of+atrial+septal+defects+in+4D+echocardiography&rft.au=Linguraru%2C+Marius+George%3BVasilyev%2C+Nikolay+V%3BMarx%2C+Gerald+R%3BTworetzky%2C+Wayne%3BDel+Nido%2C+Pedro+J%3BHowe%2C+Robert+D&rft.aulast=Linguraru&rft.aufirst=Marius&rft.date=2008-08-01&rft.volume=12&rft.issue=4&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Medical+Image+Analysis&rft.issn=13618415&rft_id=info:doi/10.1016%2Fj.media.2007.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Image processing; Heart; Information processing; Ultrasound; Algorithms; Echocardiography; Data processing DO - http://dx.doi.org/10.1016/j.media.2007.12.005 ER - TY - JOUR T1 - Literature Search and Review AN - 21025666; 8572666 AB - In each issue of ASSAY and Drug Development Technologies, our Literature Editors, Doug Auld, Ph.D., Anton Simeonov, Ph.D., and Craig Thomas, Ph.D., select several significant papers covering timely and pertinent topics that will keep our readers up-to-date on the ever-changing field of assays and drug development technologies. Drs. Auld, Simeonov, and Thomas provide relevant commentary on each of the cited abstracts. JF - Assay and Drug Development Technologies AU - Auld, D AU - Simeonov, A AU - Thomas, C AD - National Institutes of Health, Bethesda, MD, USA Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 473 EP - 490 VL - 6 IS - 4 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Drug development KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21025666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=Literature+Search+and+Review&rft.au=Auld%2C+D%3BSimeonov%2C+A%3BThomas%2C+C&rft.aulast=Auld&rft.aufirst=D&rft.date=2008-08-01&rft.volume=6&rft.issue=4&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2008.9988 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Drug development; Reviews DO - http://dx.doi.org/10.1089/adt.2008.9988 ER - TY - JOUR T1 - A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase AN - 21020803; 8572672 AB - Schistosomiasis is a major neglected tropical disease that currently affects over 200 million people and leads to over 200,000 annual deaths. Schistosoma mansoni parasites survive in humans in part because of a set of antioxidant enzymes that continuously degrade reactive oxygen species produced by the host. A principal component of this defense system has been recently identified as thioredoxin glutathione reductase (TGR), a parasite-specific enzyme that combines the functions of two human counterparts, glutathione reductase and thioredoxin reductase, and as such this enzyme presents an attractive new target for anti-schistosomiasis drug development. Herein, we present the development of a highly miniaturized and robust screening assay for TGR. The 5- mu l final volume assay is based on the Ellman reagent [5,5'-dithiobis(2-nitrobenzoic acid) (DTNB)] and utilizes a high-speed absorbance kinetic read to minimize the effect of dust, absorbance interference, and meniscus variation. This assay is further applicable to the testing of other redox enzymes that utilize DTNB as a model substrate. JF - Assay and Drug Development Technologies AU - Lea, WA AU - Jadhav, A AU - Rai, G AU - Sayed, A A AU - Cass, CL AU - Inglese, J AU - Williams, D L AU - Austin, C P AU - Simeonov, A AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3370, USA, asimeono@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 551 EP - 556 VL - 6 IS - 4 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - Thioredoxin KW - glutathione reductase KW - Schistosoma mansoni KW - Parasites KW - Antioxidants KW - Schistosomiasis KW - Thioredoxin-disulfide reductase KW - Enzymes KW - Drug development KW - Dust KW - Models KW - Reactive oxygen species KW - meniscus KW - Kinetics KW - Absorbance KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21020803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=A+1%2C536-Well-Based+Kinetic+HTS+Assay+for+Inhibitors+of+Schistosoma+mansoni+Thioredoxin+Glutathione+Reductase&rft.au=Lea%2C+WA%3BJadhav%2C+A%3BRai%2C+G%3BSayed%2C+A+A%3BCass%2C+CL%3BInglese%2C+J%3BWilliams%2C+D+L%3BAustin%2C+C+P%3BSimeonov%2C+A&rft.aulast=Lea&rft.aufirst=WA&rft.date=2008-08-01&rft.volume=6&rft.issue=4&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2008.149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Schistosoma mansoni; Enzymes; glutathione reductase; Drug development; Thioredoxin; Kinetics; Absorbance; Models; Parasites; meniscus; Thioredoxin-disulfide reductase; Dust; Antioxidants; Schistosomiasis; Reactive oxygen species DO - http://dx.doi.org/10.1089/adt.2008.149 ER - TY - JOUR T1 - Receptor "hijacking" by malignant glioma cells: A tactic for tumor progression AN - 20999701; 8619600 AB - Gliomas are the most common and deadly tumors in the central nervous system (CNS). In the course of studying the role of chemoattractant receptors in tumor growth and metastasis, we discovered that highly malignant human glioblastoma and anaplastic astrocytoma specimens were stained positively for the formylpeptide receptor (FPR), which is normally expressed in myeloid cells and accounts for their chemotaxis and activation induced by bacterial peptides. Screening of human glioma cell lines revealed that FPR was expressed selectively in glioma cell lines with a more highly malignant phenotype. FPR expressed in glioblastoma cell lines mediates cell chemotaxis, proliferation and production of an angiogenic factor, vascular endothelial growth factor (VEGF), in response to agonists released by necrotic tumor cells. Furthermore, FPR in glioblastoma cells activates the receptor for epidermal growth factor (EGFR) by increasing the phosphorylation of a selected tyrosine residue in the intracellular tail of EGFR. Thus, FPR hijacked by human glioblastoma cells exploits the function of EGFR to promote rapid tumor progression. JF - Cancer Letters AU - Huang, Jian AU - Chen, Keqiang AU - Gong, Wanghua AU - Zhou, Ye AU - Le, Yingying AU - Bian, Xiuwu AU - Wang, Ji Ming AD - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Building 560, Room 31-76, Frederick, MD 21702-1201, USA, wangji@mail.ncifcrf.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 254 EP - 261 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 267 IS - 2 SN - 0304-3835, 0304-3835 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Glioma KW - Formyl peptide receptor KW - Chemotaxis KW - Angiogenesis KW - Vascular endothelial growth factor KW - Central nervous system KW - Glioblastoma KW - Astrocytoma KW - formyl peptides KW - Tails KW - glioblastoma cells KW - Tyrosine KW - Epidermal growth factor receptors KW - Tumors KW - Myeloid cells KW - Tumor cells KW - Brain tumors KW - Metastases KW - Phosphorylation KW - Glioma cells KW - Chemotactic factors KW - Cell proliferation KW - Epidermal growth factor KW - J 02320:Cell Biology KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20999701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Receptor+%22hijacking%22+by+malignant+glioma+cells%3A+A+tactic+for+tumor+progression&rft.au=Huang%2C+Jian%3BChen%2C+Keqiang%3BGong%2C+Wanghua%3BZhou%2C+Ye%3BLe%2C+Yingying%3BBian%2C+Xiuwu%3BWang%2C+Ji+Ming&rft.aulast=Huang&rft.aufirst=Jian&rft.date=2008-08-01&rft.volume=267&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/10.1016%2Fj.canlet.2008.03.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Glioblastoma; Central nervous system; Astrocytoma; Tails; formyl peptides; glioblastoma cells; Angiogenesis; Tyrosine; Epidermal growth factor receptors; Tumors; Myeloid cells; Chemotaxis; Tumor cells; Metastases; Brain tumors; Phosphorylation; Chemotactic factors; Glioma cells; Glioma; Epidermal growth factor; Cell proliferation DO - http://dx.doi.org/10.1016/j.canlet.2008.03.014 ER - TY - JOUR T1 - Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA super(Met) and AUG selection AN - 20996615; 8405704 AB - High-resolution structures of bacterial 70S ribosomes have provided atomic details about mRNA and tRNA binding to the decoding center during elongation, but such information is lacking for preinitiation complexes (PICs). We identified residues in yeast 18S rRNA critical in vivo for recruiting methionyl tRNA sub(i) super(Met) to 40S subunits during initiation by isolating mutations that derepress GCN4 mRNA translation. Several such Gcd super(-) mutations alter the A928:U1389 base pair in helix 28 (h28) and allow PICs to scan through the start codons of upstream ORFs that normally repress GCN4 translation. The A928U substitution also impairs TC binding to PICs in a reconstituted system in vitro. Mutation of the bulge G926 in h28 and certain other residues corresponding to direct contacts with the P-site codon or tRNA in bacterial 70S complexes confer Gcd super(-) phenotypes that (like A928 substitutions) are suppressed by overexpressing tRNA sub(i) super(Met). Hence, the nonconserved 928:1389 base pair in h28, plus conserved 18S rRNA residues corresponding to P-site contacts in bacterial ribosomes, are critical for efficient Met-tRNA sub(i) super(Met) binding and AUG selection in eukaryotes. JF - Genes & Development AU - Dong, Jinsheng AU - Nanda, Jagpreet S AU - Rahman, Hafsa AU - Pruitt, Margaret R AU - Shin, Byung-Sik AU - Wong, Chi-Ming AU - Lorsch, Jon R AU - Hinnebusch, Alan G AD - Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 2242 EP - 2255 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 22 IS - 16 SN - 0890-9369, 0890-9369 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - rRNA 18S KW - Translation KW - Elongation KW - tRNA KW - Recruitment KW - Codons KW - Ribosomes KW - Mutation KW - Base pairs KW - J 02410:Animal Diseases KW - N 14830:RNA KW - G 07730:Development & Cell Cycle KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20996615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Genetic+identification+of+yeast+18S+rRNA+residues+required+for+efficient+recruitment+of+initiator+tRNA+super%28Met%29+and+AUG+selection&rft.au=Dong%2C+Jinsheng%3BNanda%2C+Jagpreet+S%3BRahman%2C+Hafsa%3BPruitt%2C+Margaret+R%3BShin%2C+Byung-Sik%3BWong%2C+Chi-Ming%3BLorsch%2C+Jon+R%3BHinnebusch%2C+Alan+G&rft.aulast=Dong&rft.aufirst=Jinsheng&rft.date=2008-08-01&rft.volume=22&rft.issue=16&rft.spage=2242&rft.isbn=&rft.btitle=&rft.title=Genes+%26+Development&rft.issn=08909369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - rRNA 18S; Elongation; Translation; tRNA; Recruitment; Codons; Ribosomes; Mutation; Base pairs ER - TY - JOUR T1 - The role of virulence determinants in community-associated MRSA pathogenesis AN - 20968413; 8493667 AB - The recent emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) marked a quantum change in the biology and epidemiology of a major human pathogen. Various virulence determinants unique to CA-MRSA have been uncovered recently, which shed light on how these strains spread easily and sustainably among humans and frequently cause severe disease. The role of the Panton Valentine leukocidin (PVL) in CA-MRSA pathogenesis is a matter of much debate. Although epidemiological data have indicated a role for PVL in the CA-MRSA disease process, recent data from relevant animal models indicate that PVL does not impact virulence of prevalent CA-MRSA strains. Identifying specialized pathogenic traits of CA-MRSA remains a challenge that will yield new diagnostic tools and therapeutic targets for drug and vaccine development. Here, we discuss the roles of PVL, the arginine catabolic mobile element and phenol-soluble modulins in the pathogenesis of prevalent CA-MRSA strains. JF - Trends in Microbiology AU - Diep, BA AU - Otto, M Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 361 EP - 369 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 16 IS - 8 SN - 0966-842X, 0966-842X KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - leukocidin KW - Arginine KW - Drug resistance KW - Animal models KW - Drug development KW - Pathogens KW - Virulence KW - Epidemiology KW - Reviews KW - Vaccines KW - Staphylococcus aureus KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20968413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Microbiology&rft.atitle=The+role+of+virulence+determinants+in+community-associated+MRSA+pathogenesis&rft.au=Diep%2C+BA%3BOtto%2C+M&rft.aulast=Diep&rft.aufirst=BA&rft.date=2008-08-01&rft.volume=16&rft.issue=8&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Trends+in+Microbiology&rft.issn=0966842X&rft_id=info:doi/10.1016%2Fj.tim.2008.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virulence; Data processing; Epidemiology; leukocidin; Arginine; Reviews; Drug resistance; Animal models; Drug development; Vaccines; Pathogens; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.tim.2008.05.002 ER - TY - JOUR T1 - The allergy archives: Asthma and athletics AN - 20964467; 8432298 AB - Abstract not available. JF - Journal of Allergy and Clinical Immunology AU - Cohen, Sheldon G AD - National Institute of Allergy and Infectious Diseases, and the National Library of Medicine, National Institutes of Health, Bethesda, Md, scohen@niaid.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 435 EP - 439.e3 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA, [mailto:membership@aaaai.org], [URL:http://www.aaai.org] VL - 122 IS - 2 SN - 0091-6749, 0091-6749 KW - Physical Education Index; Immunology Abstracts KW - Athletics KW - Hypersensitivity KW - Immune system KW - Asthma KW - Archives KW - Allergies KW - F 06925:Hypersensitivity KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20964467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=The+allergy+archives%3A+Asthma+and+athletics&rft.au=Cohen%2C+Sheldon+G&rft.aulast=Cohen&rft.aufirst=Sheldon&rft.date=2008-08-01&rft.volume=122&rft.issue=2&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2008.05.046 LA - English DB - Physical Education Index N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Allergies; Asthma; Archives; Immune system; Athletics; Hypersensitivity DO - http://dx.doi.org/10.1016/j.jaci.2008.05.046 ER - TY - JOUR T1 - Gastrocnemius Fascicle Length Changes With Two-Joint Passive Movements AN - 20924432; 8492459 AB - Predicting muscle fascicle length changes during passive movements may lead to a better understanding of muscle function. The purpose of this study was to experimentally compare fascicle length changes in the gastrocnemius during two-joint passive movements with a previously derived kinematic model based on anatomical measures from a cadaver. The ratio of passive ankle to knee motion was manipulated to generate medial gastrocnemius fascicle elongation and lateral gastrocnemius fascicle shortening. Ultrasound images from both heads of the gastrocnemius fascicles were acquired at 10 degree knee flexion increments and compared with this kinematic model. Our results suggest that the two-joint kinematic model from which we originally based our knee and ankle movements did not adequately reflect fascicle length changes during any of the movement conditions in this study. From our data, we propose that for every degree of ankle motion the medial and lateral gastrocnemius changes 0.42 mm and 0.96 mm, respectively, whereas changes of 0.14 mm and 0.22 mm are observed for the medial and lateral gastrocnemius, respectively, during knee movements. JF - Journal of Applied Biomechanics AU - Brindle, T J AU - Miller, J L AU - Lebiedowska, M K AU - Stanhope, S J AD - Biomechanics Laboratory, National Institutes of Health, Bethesda, MD, USA Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 252 EP - 261 VL - 24 IS - 3 SN - 1065-8483, 1065-8483 KW - Physical Education Index KW - Kinematics KW - Muscles (size) KW - Passive movement KW - Ankles KW - Knees KW - Ultrasound KW - Movement KW - Biomechanics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20924432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Biomechanics&rft.atitle=Gastrocnemius+Fascicle+Length+Changes+With+Two-Joint+Passive+Movements&rft.au=Brindle%2C+T+J%3BMiller%2C+J+L%3BLebiedowska%2C+M+K%3BStanhope%2C+S+J&rft.aulast=Brindle&rft.aufirst=T&rft.date=2008-08-01&rft.volume=24&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Biomechanics&rft.issn=10658483&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Movement; Knees; Kinematics; Ankles; Passive movement; Muscles (size); Biomechanics; Ultrasound ER - TY - JOUR T1 - Synthetic growth phenotypes of Escherichia coli lacking ppGpp and transketolase A (tktA) are due to ppGpp-mediated transcriptional regulation of tktB AN - 20912173; 8396339 AB - Many physiological adjustments to nutrient changes involve ppGpp. Recent attempts to deduce ppGpp regulatory effects using proteomics or gene profiling can rigorously identify proteins or transcripts, but the functional significance is often unclear. Using a random screen for synthetic lethals we found a ppGpp-dependent functional pathway that operates through transketolase B (TktB), and which is 'buffered' in wildtype strain by the presence of an isozyme, transketolase A (TktA). Transketolase activity is required in cells to make erythrose-4-phosphate, a precursor of aromatic amino acids and vitamins. By studying tktB-dependent nutritional requirements as well as measuring activities using PtalA-tktB'-lacZ transcriptional reporter fusion, we show positive transcriptional regulation of the talA-tktB operon by ppGpp. Our results show the existence of RpoS-dependent and RpoS-independent modes of positive regulation by ppGpp. Both routes of activation are magnified by elevating ppGpp levels with a spoT mutation (spoT-R39A) defective in hydrolase but not synthetase activity or with the stringent suppressor mutations rpoB-A532 or rpoB-T563P in the absence of ppGpp. JF - Molecular Microbiology AU - Harinarayanan, Rajendran AU - Murphy, Helen AU - Cashel, Michael AD - Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD20892, USA., harinarr@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 882 EP - 894 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 69 IS - 4 SN - 0950-382X, 0950-382X KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Amino acids KW - Transcription KW - Nutrients KW - Transketolase KW - hydrolase KW - Gene regulation KW - Vitamins KW - Escherichia coli KW - Isoenzymes KW - proteomics KW - Genetic suppression KW - Operons KW - Aromatics KW - J 02320:Cell Biology KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20912173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Synthetic+growth+phenotypes+of+Escherichia+coli+lacking+ppGpp+and+transketolase+A+%28tktA%29+are+due+to+ppGpp-mediated+transcriptional+regulation+of+tktB&rft.au=Harinarayanan%2C+Rajendran%3BMurphy%2C+Helen%3BCashel%2C+Michael&rft.aulast=Harinarayanan&rft.aufirst=Rajendran&rft.date=2008-08-01&rft.volume=69&rft.issue=4&rft.spage=882&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06317.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - hydrolase; Transketolase; Amino acids; Vitamins; Gene regulation; Isoenzymes; Transcription; Nutrients; Genetic suppression; proteomics; Operons; Aromatics; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06317.x ER - TY - JOUR T1 - Letter to the Editor: Radiation Oncology Facilities in Africa: What Is the Most Important: Equipment, Staffing, or Guidelines? AN - 20910037; 8432743 AB - Abstract not available. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Zaghloul, Mohamed S AD - Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1600 EP - 1601 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 71 IS - 5 SN - 0360-3016, 0360-3016 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20910037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Letter+to+the+Editor%3A+Radiation+Oncology+Facilities+in+Africa%3A+What+Is+the+Most+Important%3A+Equipment%2C+Staffing%2C+or+Guidelines%3F&rft.au=Zaghloul%2C+Mohamed+S&rft.aulast=Zaghloul&rft.aufirst=Mohamed&rft.date=2008-08-01&rft.volume=71&rft.issue=5&rft.spage=1600&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2008.03.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/j.ijrobp.2008.03.053 ER - TY - JOUR T1 - Adverse Childhood Experiences Predict Earlier Age of Drinking Onset: Results From a Representative US Sample of Current or Former Drinkers AN - 20894086; 8406618 AB - OBJECTIVE. Our goal was to determine whether adverse childhood experiences predicted the age at which drinking was initiated and drinking motives in a representative sample of current or former drinkers in the United States. METHODS. In 2006, a probability sample of 3592 US current or former drinkers aged 18 to 39 were surveyed. Multinomial logistic regression examined whether each of 10 adverse childhood experiences was associated with earlier ages of drinking onset, controlling for demographics, parental alcohol use, parental attitudes toward drinking, and peers' drinking in adolescence. We also examined whether there was a graded relationship between the number of adverse childhood experiences and age of drinking onset and whether adverse childhood experiences were related to self-reported motives for drinking during the first year that respondents drank. RESULTS. Sixty-six percent of respondents reported greater than or equal to 1 adverse childhood experiences, and 19% reported experiencing greater than or equal to 4. The most commonly reported adverse childhood experiences were parental separation/divorce (41.3%), living with a household member who was a problem drinker (28.7%), mental illness of a household member (24.8%), and sexual abuse (19.1%). Of the 10 specific adverse childhood experiences assessed, 5 were significantly associated with initiating drinking at less than or equal to 14 years of age (compared with at greater than or equal to 21 years of age) after adjustment for confounders, including physical abuse, sexual abuse, having a mentally ill household member, substance abuse in the home, and parental discord or divorce. Compared with those without adverse childhood experiences, respondents with adverse childhood experiences were substantially more likely to report that they drank to cope during the first year that they used alcohol. CONCLUSIONS. Results suggest that children with particular adverse childhood experiences may initiate drinking earlier than their peers and that they may be more likely to drink to cope with problems (rather than for pleasure or to be social). JF - Pediatrics AU - Rothman, Emily F AU - Edwards, Erika M AU - Heeren, Timothy AU - Hingson, Ralph W AD - Departments of Social and Behavioral Sciences. Epidemiology. Biostatistics, Boston University School of Public Health, Boston, Massachusetts. National Institute on Alcohol Abuse and Alcoholism, Division of Epidemiology and Prevention Research, Bethesda, MD Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - e298 EP - e304 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 122 IS - 2 SN - 0031-4005, 0031-4005 KW - Risk Abstracts KW - demography KW - substance abuse KW - Alcohol KW - USA KW - Age KW - households KW - Behavior KW - Children KW - mental disorders KW - attitudes KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20894086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Adverse+Childhood+Experiences+Predict+Earlier+Age+of+Drinking+Onset%3A+Results+From+a+Representative+US+Sample+of+Current+or+Former+Drinkers&rft.au=Rothman%2C+Emily+F%3BEdwards%2C+Erika+M%3BHeeren%2C+Timothy%3BHingson%2C+Ralph+W&rft.aulast=Rothman&rft.aufirst=Emily&rft.date=2008-08-01&rft.volume=122&rft.issue=2&rft.spage=e298&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - substance abuse; demography; Alcohol; households; Age; Behavior; Children; mental disorders; attitudes; USA ER - TY - JOUR T1 - Work in the textile industry in Spain and bladder cancer AN - 20891733; 8406541 AB - BACKGROUND/OBJECTIVE: Textile manufacturing is a complex industry that has frequently been associated with bladder cancer. However, results have not been consistent. This study investigated the risk of bladder cancer in Spanish textile workers. METHODS: We analysed data from a multicentre hospital-based case-control study carried out in Spain (1998-2001) including 1219 cases of bladder cancer and 1271 controls. Of those, 126 cases and 122 controls reported a history of employment in the textile industry. Lifetime occupational history was obtained using a computer-assisted personal interview. Occupations, locations and materials used in the textile industry were assessed using a detailed questionnaire and expert assessment. RESULTS: Overall, no increased risk of bladder cancer was found for textile workers, including duration of employment analysis. Increased risks were observed for weavers (OR = 1.82, 95% CI 0.95 to 3.47), for workers in winding/warping/sizing (OR 4.11, 95% CI 1.58 to 10.71) and for those exposed to synthetic materials (OR 1.89, 95% CI 1.00 to 3.56). Working for more than 10 years appeared to be associated with an increased risk for weavers (OR 2.27, 95% CI 0.97 to 5.34), for those who had ever worked in winding/warping/sizing (OR 11.03, 95% CI 1.37, 88.89), for workers in the weaving room (OR 2.94, 95% CI 1.24 to 7.01) and for those exposed to synthetic (OR 2.62, 95% CI 1.14 to 6.01) or cotton (OR 2.00, 95% CI 1.04 to 3.87) materials. Statistically significant higher risks were also found for specific combinations of occupations or locations with exposure to synthetics and cotton. CONCLUSIONS: There was no overall increased risk for textile workers, but increased risks were found for specific groups of workers. Our findings indicate that observed risks in previous studies may be better evaluated by analysis of materials used or section worked within the industry and occupation. JF - Occupational and Environmental Medicine AU - Serra, C AU - Kogevinas, M AU - Silverman, D T AU - Turuguet, D AU - Tardon, A AU - Garcia-Closas, R AU - Carrato, A AU - Castano-Vinyals, G AU - Fernandez, F AU - Stewart, P AU - Benavides, F G AU - Gonzalez, S AU - Serra, A AU - Rothman, N AU - Malats, N AU - Dosemeci, M AD - Unit of Research in Occupational Health, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain Corporacio Parc Tauli, Sabadell, Spain Centre for Research in Environmental Epidemiology (CREAL), Municipal Institute of Medical Research, Barcelona, Spain Department of Social Medicine, Medical School, University of Crete, Heraklion, Crete, Greece Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA Chemist, private Universidad de Oviedo, Oviedo, Spain Hospital Universitario de Canarias, La Laguna, Tenerife, Spain Hospital General de Elche, Elche, Spain CIBER en Salud Publica y Epidemiologia, Barcelona, Spain Industrial hygienist, formerly with the Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA Industrial engineer, private Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 552 EP - 559 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 8 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - urinary bladder KW - Historical account KW - Cotton KW - Spain KW - Textile industry KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20891733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Work+in+the+textile+industry+in+Spain+and+bladder+cancer&rft.au=Serra%2C+C%3BKogevinas%2C+M%3BSilverman%2C+D+T%3BTuruguet%2C+D%3BTardon%2C+A%3BGarcia-Closas%2C+R%3BCarrato%2C+A%3BCastano-Vinyals%2C+G%3BFernandez%2C+F%3BStewart%2C+P%3BBenavides%2C+F+G%3BGonzalez%2C+S%3BSerra%2C+A%3BRothman%2C+N%3BMalats%2C+N%3BDosemeci%2C+M&rft.aulast=Serra&rft.aufirst=C&rft.date=2008-08-01&rft.volume=65&rft.issue=8&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Historical account; urinary bladder; Cotton; Textile industry; Occupational exposure; Spain ER - TY - JOUR T1 - The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin AN - 20888930; 8389601 AB - Diphthamide is a post-translational derivative of histidine in protein synthesis elongation factor-2 (eEF-2) that is present in all eukaryotes with no known normal physiological role. Five proteins Dph1-Dph5 are required for the biosynthesis of diphthamide. Chinese hamster ovary (CHO) cells mutated in the biosynthetic genes lack diphthamide and are resistant to bacterial toxins such as diphtheria toxin. We found that diphthamide-deficient cultured cells were threefold more sensitive than their parental cells towards ricin, a ribosome-inactivating protein (RIP). RIPs bind to ribosomes at the same site as eEF-2 and cleave the large ribosomal RNA, inhibiting translation and causing cell death. We hypothesized that one role of diphthamide may be to protect ribosomes, and therefore all eukaryotic life forms, from RIPs, which are widely distributed in nature. A protective role of diphthamide against ricin was further demonstrated by complementation where dph mutant CHO cells transfected with the corresponding DPH gene acquired increased resistance to ricin in comparison with the control-transfected cells, and resembled the parental CHO cells in their response to the toxin. These data show that the presence of diphthamide in eEF-2 provides protection against ricin and suggest the hypothesis that diphthamide may have evolved to provide protection against RIPs. JF - Cellular Microbiology AU - Gupta, Pradeep K AU - Liu, Shihui AU - Batavia, Mariska P AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD20892, USA., sleppla@niaid.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1687 EP - 1694 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 10 IS - 8 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Translation KW - Data processing KW - Protein biosynthesis KW - Ricin KW - Ribosomes KW - Diphtheria toxin KW - Toxins KW - rRNA KW - Elongation KW - Cell death KW - Complementation KW - Mammalian cells KW - Post-translation KW - Histidine KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20888930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=The+diphthamide+modification+on+elongation+factor-2+renders+mammalian+cells+resistant+to+ricin&rft.au=Gupta%2C+Pradeep+K%3BLiu%2C+Shihui%3BBatavia%2C+Mariska+P%3BLeppla%2C+Stephen+H&rft.aulast=Gupta&rft.aufirst=Pradeep&rft.date=2008-08-01&rft.volume=10&rft.issue=8&rft.spage=1687&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2008.01159.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Translation; Protein biosynthesis; Data processing; Ricin; Ribosomes; Toxins; Diphtheria toxin; Elongation; rRNA; Cell death; Complementation; Post-translation; Mammalian cells; Histidine DO - http://dx.doi.org/10.1111/j.1462-5822.2008.01159.x ER - TY - JOUR T1 - An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes AN - 20888892; 8407082 AB - Recombinant immunotoxins are hybrid proteins composed of an Fv that binds to a tumor antigen fused to a bacterial or plant toxin. Immunotoxin BL22 targets CD22 positive malignancies and is composed of an anti-CD22 Fv fused to a 38-kDa fragment of Pseudomonas exotoxin A (PE38). BL22 has produced many complete remissions in drug-resistant Hairy cell leukemia, where many treatment cycles can be given, because neutralizing antibodies do not form. In marked contrast, only minor responses have been observed in trials with immunotoxins targeting solid tumors, because only a single treatment cycle can be given before antibodies develop. To allow more treatment cycles and increase efficacy, we have produced a less immunogenic immunotoxin by identifying and eliminating most of the B cell epitopes on PE38. This was accomplished by mutation of specific large hydrophilic amino acids (Arg, Gln, Glu, Lys) to Ala, Ser, or Gly. The new immunotoxin (HA22-8X) is significantly less immunogenic in three strains of mice, yet retains full cytotoxic and anti-tumor activities. Elimination of B-cell epitopes is a promising approach to the production of less immunogenic proteins for therapeutic purposes. JF - Proceedings of the National Academy of Sciences, USA AU - Onda, Masanori AU - Beers, Richard AU - Xiang, Laiman AU - Nagata, Satoshi AU - Wang, Qing-cheng AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264 Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 11311 EP - 11316 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 32 SN - 0027-8424, 0027-8424 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Amino acids KW - Solid tumors KW - Lymphocytes B KW - Drug resistance KW - Therapeutic applications KW - Remission KW - Pseudomonas KW - Tumors KW - exotoxin A KW - Antitumor agents KW - Fv KW - Immunotoxins KW - Toxins KW - CD22 antigen KW - Antibodies KW - Cytotoxicity KW - Malignancy KW - Immunogenicity KW - Hybrids KW - Antigen (tumor-associated) KW - Mutation KW - Hairy cell leukemia KW - Epitopes KW - F 06915:Cancer Immunology KW - J 02350:Immunology KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20888892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=An+immunotoxin+with+greatly+reduced+immunogenicity+by+identification+and+removal+of+B+cell+epitopes&rft.au=Onda%2C+Masanori%3BBeers%2C+Richard%3BXiang%2C+Laiman%3BNagata%2C+Satoshi%3BWang%2C+Qing-cheng%3BPastan%2C+Ira&rft.aulast=Onda&rft.aufirst=Masanori&rft.date=2008-08-01&rft.volume=105&rft.issue=32&rft.spage=11311&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amino acids; Lymphocytes B; Solid tumors; Drug resistance; Remission; Therapeutic applications; Tumors; Antitumor agents; exotoxin A; Toxins; Immunotoxins; Fv; Malignancy; Cytotoxicity; Antibodies; CD22 antigen; Immunogenicity; Hybrids; Antigen (tumor-associated); Hairy cell leukemia; Mutation; Epitopes; Pseudomonas ER - TY - JOUR T1 - NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B AN - 20887957; 8424811 AB - The NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B has been determined. Chz1 forms a long irregular chain capped by two short [alpha]-helices, and uses both positively and negatively charged residues to stabilize the histone dimer. A molecular model that docks Chz1 onto the nucleosome has implications for its potential functions. JF - Nature Structural & Molecular Biology AU - Zhou, Zheng AU - Feng, Hanqiao AU - Hansen, D Flemming AU - Kato, Hidenori AU - Luk, Ed AU - Freedberg, Daron I AU - Kay, Lewis E AU - Wu, Carl AU - Bai, Yawen Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 868 EP - 869 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 8 SN - 1545-9993, 1545-9993 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Nucleosomes KW - Histones KW - N.M.R. KW - Chaperones KW - Saccharomyces cerevisiae KW - W 30910:Imaging KW - N 14820:DNA Metabolism & Structure KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20887957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Structural+%26+Molecular+Biology&rft.atitle=NMR+structure+of+chaperone+Chz1+complexed+with+histones+H2A.Z-H2B&rft.au=Zhou%2C+Zheng%3BFeng%2C+Hanqiao%3BHansen%2C+D+Flemming%3BKato%2C+Hidenori%3BLuk%2C+Ed%3BFreedberg%2C+Daron+I%3BKay%2C+Lewis+E%3BWu%2C+Carl%3BBai%2C+Yawen&rft.aulast=Zhou&rft.aufirst=Zheng&rft.date=2008-08-01&rft.volume=15&rft.issue=8&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=Nature+Structural+%26+Molecular+Biology&rft.issn=15459993&rft_id=info:doi/10.1038%2Fnsmb.1465 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Nucleosomes; Histones; Chaperones; N.M.R.; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1038/nsmb.1465 ER - TY - JOUR T1 - Pulsed High-Intensity Focused Ultrasound Enhances Apoptosis and Growth Inhibition of Squamous Cell Carcinoma Xenografts with Proteasome Inhibitor Bortezomib AN - 20880051; 8407395 AB - PURPOSE: To investigate whether combining pulsed high-intensity focused ultrasound (HIFU) with the chemotherapeutic drug bortezomib could improve antitumor activity against murine squamous cell carcinoma (SCC) tumors. MATERIALS AND METHODS: All experiments were conducted with animal care and use committee approval. Murine SCC cells were implanted subcutaneously in C3H mice. When tumors reached 100 mm super(3), mice were randomized to one of three groups for twice weekly intraperitoneal injections of 1.5 mg of bortezomib per kilogram of body weight, a proteasome inhibitor (n = 10); 1.0 mg/kg bortezomib (n = 11); or a control vehicle (n = 12). Within each group, half of the mice received pulsed HIFU exposure to their tumors immediately prior to each injection. The time for tumors to reach 650 mm super(3) was compared among groups. Additional tumors were stained with terminal deoxynucledotidyl transferase-mediated dUTP nick end labeling and CD31 to assess apoptotic index and blood vessel density, respectively. RESULTS: Tumors in the control group, pulsed HIFU and control group, and 1.0 mg/kg of bortezomib alone group reached the size end point in 5.2 days plus or minus 0.8 (standard deviation), 5.3 days plus or minus 0.8, and 5.6 days plus or minus 1.1, respectively. However, pulsed HIFU and 1.0 mg/kg bortezomib increased the time to end point to 9.8 days plus or minus 2.9 (P .05). Combination therapy was also associated with a significantly higher apoptotic index (P < .05). CONCLUSION: Treatment of tumors with pulsed HIFU lowered the threshold level for efficacy of bortezomib, resulting in significant tumor cytotoxicity and growth inhibition at lower dose levels. [copy ] RSNA, 2008 JF - Radiology AU - Poff, Jason A AU - Allen, Clint T AU - Traughber, Bryan AU - Colunga, Aric AU - Xie, Jianwu AU - Chen, Zhong AU - Wood, Bradford J AU - Van Waes, Carter AU - Li, King CP AU - Frenkel, Victor AD - Diagnostic Radiology Department, Clinical Center (J.A.P., B.T., A.C., J.X., B.J.W., K.C.P.L., V.F.) and Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders (NIDCD) (C.T.A., Z.C., C.V.W.), National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, MD 20892 Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 485 EP - 491 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 248 IS - 2 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Bortezomib KW - squamous cell carcinoma KW - Tumors KW - Cytotoxicity KW - Standard deviation KW - Body weight KW - Blood vessels KW - Xenografts KW - Drugs KW - Ultrasound KW - proteasome inhibitors KW - Antitumor activity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20880051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Pulsed+High-Intensity+Focused+Ultrasound+Enhances+Apoptosis+and+Growth+Inhibition+of+Squamous+Cell+Carcinoma+Xenografts+with+Proteasome+Inhibitor+Bortezomib&rft.au=Poff%2C+Jason+A%3BAllen%2C+Clint+T%3BTraughber%2C+Bryan%3BColunga%2C+Aric%3BXie%2C+Jianwu%3BChen%2C+Zhong%3BWood%2C+Bradford+J%3BVan+Waes%2C+Carter%3BLi%2C+King+CP%3BFrenkel%2C+Victor&rft.aulast=Poff&rft.aufirst=Jason&rft.date=2008-08-01&rft.volume=248&rft.issue=2&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Apoptosis; Bortezomib; squamous cell carcinoma; Tumors; Cytotoxicity; Standard deviation; Blood vessels; Body weight; Xenografts; Ultrasound; Drugs; proteasome inhibitors; Antitumor activity ER - TY - JOUR T1 - Computational study of the putative active form of protein Z (PZa): Sequence design and structural modeling AN - 20873782; 8407264 AB - Although protein Z (PZ) has a domain arrangement similar to the essential coagulation proteins FVII, FIX, FX, and protein C, its serine protease (SP)-like domain is incomplete and does not exhibit proteolytic activity. We have generated a trial sequence of putative activated protein Z (PZa) by identifying amino acid mutations in the SP-like domain that might reasonably resurrect the serine protease catalytic activity of PZ. The structure of the activated form was then modeled based on the proposed sequence using homology modeling and solvent-equilibrated molecular dynamics simulations. In silico docking of inhibitors of FVIIa and FXa to the putative active site of equilibrated PZa, along with structural comparison with its homologous proteins, suggest that the designed PZa can possibly act as a serine protease. JF - Protein Science AU - Chandrasekaran, Vasu AU - Lee, Chang Jun AU - Duke, Robert E AU - Perera, Lalith AU - Pedersen, Lee G AD - Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. Laboratory of Structural Biology, National Institute of Environmental Health Sciences-National Institutes of Health, Research Triangle Park, North Carolina 27709, USA Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1354 EP - 1361 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 17 IS - 8 SN - 0961-8368, 0961-8368 KW - Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - Serine proteinase KW - protein C KW - Coagulation KW - Homology KW - Computer applications KW - Mutation KW - Amino acid sequence KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20873782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Computational+study+of+the+putative+active+form+of+protein+Z+%28PZa%29%3A+Sequence+design+and+structural+modeling&rft.au=Chandrasekaran%2C+Vasu%3BLee%2C+Chang+Jun%3BDuke%2C+Robert+E%3BPerera%2C+Lalith%3BPedersen%2C+Lee+G&rft.aulast=Chandrasekaran&rft.aufirst=Vasu&rft.date=2008-08-01&rft.volume=17&rft.issue=8&rft.spage=1354&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Proteolysis; Homology; Coagulation; protein C; Serine proteinase; Computer applications; Mutation; Amino acid sequence ER - TY - JOUR T1 - Diffusion-weighted radial fast spin-echo for high-resolution diffusion tensor imaging at 3T AN - 20857212; 8377752 AB - There is a need for an imaging sequence that can provide high-resolution diffusion tensor images at 3T near air-tissue interfaces. By employing a radial fast spin-echo (FSE) collection in conjunction with magnitude filtered back-projection reconstruction, high-resolution diffusion-weighted images can be produced without susceptibility artifacts. However, violation of the Carr-Purcell-Meiboom-Gill (CPMG) condition of diffusion prepared magnetization is a prominent problem for FSE trains that is magnified at higher fields. The unique aspect of violating the CPMG condition in trajectories that oversample the center of k-space and the implications for choosing the solution are examined. For collecting diffusion-weighted radial-FSE data at 3T we propose mixed-CPMG phase cycling of RF refocusing pulses combined with a 300% wider refocusing than excitation slice. It is shown that this approach produces accurate diffusion values in a phantom, and can be used to collect undistorted, high-resolution diffusion tensor images of the human brain. Magn Reson Med 60:270-276, 2008. JF - Magnetic Resonance in Medicine AU - Sarlls, Joelle E AU - Pierpaoli, Carlo AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA, sarllsjo@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 270 EP - 276 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 60 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Data processing KW - Magnetic resonance imaging KW - Brain KW - Image processing KW - N.M.R. KW - Diffusion KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Diffusion-weighted+radial+fast+spin-echo+for+high-resolution+diffusion+tensor+imaging+at+3T&rft.au=Sarlls%2C+Joelle+E%3BPierpaoli%2C+Carlo&rft.aulast=Sarlls&rft.aufirst=Joelle&rft.date=2008-08-01&rft.volume=60&rft.issue=2&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diffusion; Neuroimaging; N.M.R.; Magnetic resonance imaging; Data processing; Image processing; Brain DO - http://dx.doi.org/10.1002/mrm.21639 ER - TY - JOUR T1 - Use of radiolabeled monoclonal antibody to enhance vaccine-mediated antitumor effects AN - 20818596; 8319005 AB - Radiolabeled monoclonal antibodies (mAb) have demonstrated measurable antitumor effects in hematologic malignancies. This outcome has been more difficult to achieve for solid tumors due, for the most part, to difficulties in delivering sufficient quantities of mAb to the tumor mass. Previous studies have shown that nonlytic levels of external beam radiation can render tumor cells more susceptible to T cell-mediated killing. The goal of these studies was to determine if the selective delivery of a radiolabeled mAb to tumors would modulate tumor cell phenotype so as to enhance vaccine-mediated T-cell killing. Here, mice transgenic for human carcinoembryonic antigen (CEA) were transplanted with a CEA expressing murine carcinoma cell line. Radioimmunotherapy consisted of yttrium-90 (Y-90)-labeled anti-CEA mAb, used either alone or in combination with vaccine therapy. A single dose of Y-90-labeled anti-CEA mAb, in combination with vaccine therapy, resulted in a statistically significant increase in survival in tumor-bearing mice over vaccine or mAb alone; this was shown to be mediated by engagement of the Fas/Fas ligand pathway. Mice receiving the combination therapy also showed a significant increase in the percentage of viable tumor-infiltrating CEA-specific CD8 super(+) T cells compared to vaccine alone. Mice cured of tumors demonstrated an antigen cascade resulting in CD4 super(+) and CD8 super(+) T-cell responses not only for CEA, but for p53 and gp70. These results show that systemic radiotherapy in the form of radiolabeled mAb, in combination with vaccine, promotes effective antitumor response, which may have implications in the design of future clinical trials. JF - Cancer Immunology, Immunotherapy AU - Chakraborty, Mala AU - Gelbard, Alexander AU - Carrasquillo, Jorge A AU - Yu, Sarah AU - Mamede, Marcelo AU - Paik, Chang H AU - Camphausen, Kevin AU - Schlom, Jeffrey AU - Hodge, James W AD - National Cancer Institute, National Institutes of Health, 10 Center Drive, Room 8B09, Bethesda, MD, 20892, USA, js141c@nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1173 EP - 1183 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 57 IS - 8 SN - 0340-7004, 0340-7004 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Solid tumors KW - Monoclonal antibodies KW - Immunotherapy KW - Carcinoembryonic antigen KW - FasL protein KW - Statistical analysis KW - Radiotherapy KW - CD8 antigen KW - Transgenic mice KW - Clinical trials KW - Tumor cells KW - p53 protein KW - Carcinoma KW - Tumor cell lines KW - CD4 antigen KW - Malignancy KW - Radiation KW - Fas antigen KW - Lymphocytes T KW - CD95 antigen KW - Vaccines KW - Antitumor activity KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20818596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Immunology%2C+Immunotherapy&rft.atitle=Use+of+radiolabeled+monoclonal+antibody+to+enhance+vaccine-mediated+antitumor+effects&rft.au=Chakraborty%2C+Mala%3BGelbard%2C+Alexander%3BCarrasquillo%2C+Jorge+A%3BYu%2C+Sarah%3BMamede%2C+Marcelo%3BPaik%2C+Chang+H%3BCamphausen%2C+Kevin%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Chakraborty&rft.aufirst=Mala&rft.date=2008-08-01&rft.volume=57&rft.issue=8&rft.spage=1173&rft.isbn=&rft.btitle=&rft.title=Cancer+Immunology%2C+Immunotherapy&rft.issn=03407004&rft_id=info:doi/10.1007%2Fs00262-008-0449-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Monoclonal antibodies; Solid tumors; Immunotherapy; FasL protein; Carcinoembryonic antigen; Statistical analysis; Radiotherapy; CD8 antigen; Transgenic mice; Tumor cells; Clinical trials; Carcinoma; p53 protein; Malignancy; CD4 antigen; Tumor cell lines; Radiation; Fas antigen; Lymphocytes T; CD95 antigen; Vaccines; Antitumor activity DO - http://dx.doi.org/10.1007/s00262-008-0449-x ER - TY - JOUR T1 - Transfusion recipient epidemiology and outcomes research: possibilities for the future AN - 20058952; 8487495 AB - The National Heart, Lung, and Blood Institute (NHLBI) supports major research programs related to the field of transfusion medicine, which encompass blood banking, the practice of transfusion medicine itself, and cellular therapies. Specific programmatic elements have included 1) the Transfusion Medicine-Hemostasis Clinical Trials Network (TMH CTN) charged with conducting clinical trials in transfusion medicine and hemostasis; 2) the Retrovirus Epidemiology Donor Study-II (REDS-II), which includes domestic and international efforts dedicated to blood donor safety and blood availability issues; 3) the Specialized Centers of Clinically Oriented Research (SCCOR) in Transfusion Biology and Medicine that include two major projects, the Biologic and Immunologic Aspects of Transfusion Medicine Program and the Transfusion and Lung Injury Program, and 4) the Transfusion Therapy Trial for Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair (FOCUS), a Phase III clinical trial that has as its major goal to determine whether a more aggressive transfusion strategy in surgery patients with cardiovascular disease (or risk factors) is associated with improved functional recovery and decreased risk of adverse postoperative outcomes. Notably, none of these programs supports epidemiologic and clinical outcomes research focused on transfusion recipients. Thus, on October 31, 2007, a Working Group on Transfusion Recipient Epidemiology and Outcomes Research was convened by the NHLBI. This group was asked to discuss the current status of the field, identify critical research needs, and make recommendations to the NHLBI program staff. JF - Transfusion AU - Hillyer, Christopher D AU - Blumberg, Neil AU - Glynn, Simone A AU - Ness, Paul M AD - From the Blood Bank, Emory University Hospital, Atlanta, Georgia; the Blood Bank, University of Rochester, Rochester, New York; DBDR, NHLBI, Bethesda, Maryland; and Blood Bank, Johns Hopkins Hospital, Baltimore, Maryland., chillye@emory.edu Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1530 EP - 1537 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 48 IS - 8 SN - 0041-1132, 0041-1132 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - transfusion KW - clinical trials KW - Transfusion KW - Recovery of function KW - Clinical trials KW - surgery KW - Retrovirus KW - Risk factors KW - Surgery KW - blood donors KW - banking KW - Heart KW - Blood donors KW - Fractures KW - hip fracture KW - Epidemiology KW - Lung KW - hemostasis KW - Cardiovascular diseases KW - Research programs KW - Hip KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20058952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Transfusion+recipient+epidemiology+and+outcomes+research%3A+possibilities+for+the+future&rft.au=Hillyer%2C+Christopher+D%3BBlumberg%2C+Neil%3BGlynn%2C+Simone+A%3BNess%2C+Paul+M&rft.aulast=Hillyer&rft.aufirst=Christopher&rft.date=2008-08-01&rft.volume=48&rft.issue=8&rft.spage=1530&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2008.01807.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Blood donors; Injuries; Fractures; Transfusion; Clinical trials; Recovery of function; Retrovirus; Epidemiology; hemostasis; Lung; Surgery; Risk factors; Cardiovascular diseases; Research programs; Hip; hip fracture; blood donors; banking; transfusion; clinical trials; surgery DO - http://dx.doi.org/10.1111/j.1537-2995.2008.01807.x ER - TY - JOUR T1 - Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS AN - 20035275; 8406483 AB - Enteroendocrine cells are hormone-secreting cells spread along the intestinal epithelium. Their principal function is to promote the digestion of food. However, little is known about other functions that these cells may play, since they are difficult to study as a whole endocrine organ due to their diffuse localization. It is known that the intestinal epithelial barrier is actively involved in the host defense against pathogen invasion. Here we applied gene expression profiling to characterize the response of the human LCC-18 enteroendocrine cell line to physiological and pathological stimuli mimicked by fatty acids (FAs), flagellin and LPS exposure. We observed that these cells participate in an innate immune reaction to pathogens through the expression of pro-inflammatory factors (i.e. CXCL1 and 3 and IL-32) that we could validate by molecular and proteomic approach. Interestingly, IL-32 has been recently found over-expressed in the inflamed mucosa of patients affected by inflammatory bowel disease. This is very important because modifications of enteroendocrine cells during intestinal inflammation have been so far considered as secondary effects of the inflammatory status rather than due to direct pathogen/enteroendocrine cell interaction. As expected, FAs exposure up-regulates pro-differentiative genes and the production of cholecystokinin but it does not enhance the expression of pro-inflammatory genes. The present observations enlighten a new aspect of the cross talk between immune and endocrine system and suggest enteroendocrine cells as important contributors of inflammatory processes occurring in the gut in response to pathogen exposure and direct enhancers of the inflammatory status associated with human inflammatory bowel disease. JF - International Immunology AU - Selleri, Silvia AU - Palazzo, Marco AU - Deola, Sara AU - Wang, Ena AU - Balsari, Andrea AU - Marincola, Francesco M AU - Rumio, Cristiano AD - Mucosal Immunity Laboratory, Department of Human Morphology, Universita degli Studi di Milano, via Mangiagalli 31, 20133 Milano, Italy. Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Molecular Targeting Unit, Istituto Nazionale Tumori, via Venezian 1 and Institute of Pathology, Universita degli Studi di Milano, via Mangiagalli 31, 20133 Milano, Italy Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 961 EP - 970 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 20 IS - 8 SN - 0953-8178, 0953-8178 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bacteria KW - Cholecystokinin KW - Food KW - Mucosa KW - Pathogens KW - Inflammation KW - Gene expression KW - Digestion KW - Enhancers KW - Digestive tract KW - Inflammatory bowel diseases KW - Fas antigen KW - Fatty acids KW - Intestine KW - CD95 antigen KW - Lipopolysaccharides KW - Epithelium KW - proteomics KW - Cell interactions KW - Endocrine system KW - Flagellin KW - Toll-like receptors KW - A 01330:Food Microbiology KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20035275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Immunology&rft.atitle=Induction+of+pro-inflammatory+programs+in+enteroendocrine+cells+by+the+Toll-like+receptor+agonists+flagellin+and+bacterial+LPS&rft.au=Selleri%2C+Silvia%3BPalazzo%2C+Marco%3BDeola%2C+Sara%3BWang%2C+Ena%3BBalsari%2C+Andrea%3BMarincola%2C+Francesco+M%3BRumio%2C+Cristiano&rft.aulast=Selleri&rft.aufirst=Silvia&rft.date=2008-08-01&rft.volume=20&rft.issue=8&rft.spage=961&rft.isbn=&rft.btitle=&rft.title=International+Immunology&rft.issn=09538178&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cholecystokinin; Food; Mucosa; Pathogens; Inflammation; Digestion; Gene expression; Enhancers; Digestive tract; Inflammatory bowel diseases; Fas antigen; Intestine; Fatty acids; Lipopolysaccharides; CD95 antigen; Epithelium; Cell interactions; proteomics; Endocrine system; Flagellin; Toll-like receptors; Bacteria ER - TY - JOUR T1 - Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study AN - 19719624; 8424771 AB - Although prognostic gene expression signatures for survival in early- stage lung cancer have been proposed, for clinical application, it is critical to establish their performance across different subject populations and in different laboratories. Here we report a large, training-testing, multi-site, blinded validation study to characterize the performance of several prognostic models based on gene expression for 442 lung adenocarcinomas. The hypotheses proposed examined whether microarray measurements of gene expression either alone or combined with basic clinical covariates (stage, age, sex) could be used to predict overall survival in lung cancer subjects. Several models examined produced risk scores that substantially correlated with actual subject outcome. Most methods performed better with clinical data, supporting the combined use of clinical and molecular information when building prognostic models for early-stage lung cancer. This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas. JF - Nature Medicine AU - Shedden, Kerby AU - Taylor, Jeremy M G AU - Enkemann, Steven A AU - Tsao, Ming-Sound AU - Yeatman, Timothy J AU - Gerald, William L AU - Eschrich, Steven AU - Jurisica, Igor AU - Giordano, Thomas J AU - Misek, David E AU - Chang, Andrew C AU - Zhu, Chang Qi AU - Strumpf, Daniel AU - Hanash, Samir AU - Shepherd, Frances A AU - Ding, Keyue AU - Seymour, Lesley AU - Naoki, Katsuhiko AU - Pennell, Nathan AU - Weir, Barbara AU - Verhaak, Roel AU - Ladd-Acosta, Christine AU - Golub, Todd AU - Gruidl, Michael AU - Sharma, Anupama AU - Szoke, Janos AU - Zakowski, Maureen AU - Rusch, Valerie AU - Kris, Mark AU - Viale, Agnes AU - Motoi, Noriko AU - Travis, William AU - Conley, Barbara AU - Seshan, Venkatraman E AU - Meyerson, Matthew AU - Kuick, Rork AU - Dobbin, Kevin K AU - Lively, Tracy AU - Jacobson, James W AU - Beer, David G AD - Department of Statistics, 1085 South University, University of Michigan, Ann Arbor, Michigan 48109, USA., jacobsonj@ctep.nci.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 822 EP - 827 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 14 IS - 8 SN - 1078-8956, 1078-8956 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Gene expression KW - Molecular modelling KW - Age KW - Data processing KW - Survival KW - Therapeutic applications KW - Adenocarcinoma KW - DNA microarrays KW - Lung cancer KW - Models KW - W 30900:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19719624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Gene+expression-based+survival+prediction+in+lung+adenocarcinoma%3A+a+multi-site%2C+blinded+validation+study&rft.au=Shedden%2C+Kerby%3BTaylor%2C+Jeremy+M+G%3BEnkemann%2C+Steven+A%3BTsao%2C+Ming-Sound%3BYeatman%2C+Timothy+J%3BGerald%2C+William+L%3BEschrich%2C+Steven%3BJurisica%2C+Igor%3BGiordano%2C+Thomas+J%3BMisek%2C+David+E%3BChang%2C+Andrew+C%3BZhu%2C+Chang+Qi%3BStrumpf%2C+Daniel%3BHanash%2C+Samir%3BShepherd%2C+Frances+A%3BDing%2C+Keyue%3BSeymour%2C+Lesley%3BNaoki%2C+Katsuhiko%3BPennell%2C+Nathan%3BWeir%2C+Barbara%3BVerhaak%2C+Roel%3BLadd-Acosta%2C+Christine%3BGolub%2C+Todd%3BGruidl%2C+Michael%3BSharma%2C+Anupama%3BSzoke%2C+Janos%3BZakowski%2C+Maureen%3BRusch%2C+Valerie%3BKris%2C+Mark%3BViale%2C+Agnes%3BMotoi%2C+Noriko%3BTravis%2C+William%3BConley%2C+Barbara%3BSeshan%2C+Venkatraman+E%3BMeyerson%2C+Matthew%3BKuick%2C+Rork%3BDobbin%2C+Kevin+K%3BLively%2C+Tracy%3BJacobson%2C+James+W%3BBeer%2C+David+G&rft.aulast=Shedden&rft.aufirst=Kerby&rft.date=2008-08-01&rft.volume=14&rft.issue=8&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm.1790 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Molecular modelling; Age; Data processing; Therapeutic applications; Survival; Adenocarcinoma; DNA microarrays; Models; Lung cancer DO - http://dx.doi.org/10.1038/nm.1790 ER - TY - JOUR T1 - Effects of Plasmodium falciparum Mixed Infections on In Vitro Antimalarial Drug Tests and Genotyping AN - 19718453; 8761994 AB - Studying drug resistance in Plasmodium falciparum requires accurate measurement of parasite response to a drug. Factors such as mixed infection of drug-resistant and -sensitive parasites can influence drug test outcome. Polymorphic DNA sequences are frequently used to detect mixed infections; infections with a single genotype or having a minor allele smaller than a subjectively selected cut-off value are often considered single infection. We studied the effects of mixed parasite populations containing various ratios of parasites resistant and sensitive to chloroquine on outcomes of drug tests and how ratios of parasite mixtures correlated with genotypes using polymerase chain reaction-based methods. Our results show that a mixture with a resistant population as low as 10% could greatly impact a drug test outcome. None of the genotyping methods could reliably detect minor DNA alleies at , 10%. Mixed infection presents a serious problem for drug tests, and genotyping using microsatellite or other methods may not reliably reflect true ratios of alleles. JF - American Journal of Tropical Medicine and Hygiene AU - Liu, S AU - Mu, J AU - Jiang, H AU - Su, X-Z AD - Laboratory of Malaria and Vector Research, National Institutes of Health, 12735 Twinbrook Parkway, Room 3E24B, Rockville, MD 20852, USA, xsu@niaid.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 178 EP - 184 VL - 79 IS - 2 SN - 0002-9637, 0002-9637 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Parasites KW - Allelles KW - Genotyping KW - Drug resistance KW - Nucleotide sequence KW - Microsatellites KW - Chloroquine KW - Plasmodium falciparum KW - Genotypes KW - Biopolymorphism KW - Population genetics KW - DNA KW - Hygiene KW - Drugs KW - Mixed infection KW - G 07880:Human Genetics KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19718453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Effects+of+Plasmodium+falciparum+Mixed+Infections+on+In+Vitro+Antimalarial+Drug+Tests+and+Genotyping&rft.au=Liu%2C+S%3BMu%2C+J%3BJiang%2C+H%3BSu%2C+X-Z&rft.aulast=Liu&rft.aufirst=S&rft.date=2008-08-01&rft.volume=79&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Population genetics; Parasites; Allelles; Nucleotide sequence; DNA; Genotypes; Hygiene; Biopolymorphism; Drugs; Drug resistance; Genotyping; Microsatellites; Chloroquine; Mixed infection; Plasmodium falciparum ER - TY - JOUR T1 - Application of mathematical models to simulate an extreme air pollution episode in the Bulgarian city of Stara Zagora AN - 19663491; 8845369 AB - The application of complex atmospheric transport and transformation mesoscale models is becoming more common for study complex environmental problems. In this contribution, we present a pollution episode occurred in the area of Stara Zagora (Bulgaria), where a large SO sub(2) industrial emitter is present. This industrial emitter accounts for more than 75% of the total SO sub(2) emissions in Bulgaria. Two monitoring stations located in Stara Zagora and Mogila observed high SO sub(2) concentration peaks for 7-11 July 2007. We have used the MM5-CMAQ air quality modelling system with CBM-IV chemical mechanism. We have used two different emission modelling tools such as SMOKE and EMIMO. In the first simulation SMOKE is used. In the second simulation, we have used EMIMO including biogenic and anthropogenic sources coming from traffic, domestic sources, etc. Additionally, in the second simulation we have used a so-called ON-OFF approach, which means that we have run two time the modelling system with and without the emissions of the large industrial plant "Maritza-Iztok", located in the surrounding area of the two monitoring stations. The use of MM5-CMAQ air quality modelling system with two different approaches, parameterizations, spatial resolution, emission modelling systems and vertical grid levels produce two significantly different results. The results show that the parameterizations and approaches for using a complex air quality modelling system such as MM5-CMAQ, are crucial for obtaining some similarities between observed and modelled data. JF - Applied Mathematical Modelling AU - Prodanova, Maria AU - Perez, Juan L AU - Syrakov, Dimiter AU - Jose, Roberto San AU - Ganev, Kostadin AU - Miloshev, Nikolai AU - Roglev, Stefan AD - National Institute of Meteorology and Hydrology (NIMH), Sofia 1784, Bulgaria, roberto@upm.es Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1607 EP - 1619 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 32 IS - 8 SN - 0307-904X, 0307-904X KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Industrial plants KW - Pollution monitoring KW - Atmospheric pollution models KW - Air quality KW - Atmospheric transport KW - Sulfur dioxide KW - Emissions KW - Urban areas KW - Mathematical models KW - anthropogenic factors KW - Simulation KW - Air quality models KW - Air pollution KW - Smoke KW - traffic KW - Numerical simulations KW - Urban atmospheric pollution KW - Mesoscale models KW - Bulgaria KW - Industrial atmospheric pollution KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19663491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Mathematical+Modelling&rft.atitle=Application+of+mathematical+models+to+simulate+an+extreme+air+pollution+episode+in+the+Bulgarian+city+of+Stara+Zagora&rft.au=Prodanova%2C+Maria%3BPerez%2C+Juan+L%3BSyrakov%2C+Dimiter%3BJose%2C+Roberto+San%3BGanev%2C+Kostadin%3BMiloshev%2C+Nikolai%3BRoglev%2C+Stefan&rft.aulast=Prodanova&rft.aufirst=Maria&rft.date=2008-08-01&rft.volume=32&rft.issue=8&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=Applied+Mathematical+Modelling&rft.issn=0307904X&rft_id=info:doi/10.1016%2Fj.apm.2007.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Bulgaria; Emissions; Pollution monitoring; Sulfur dioxide; Simulation; Air quality; Smoke; traffic; Air pollution; Industrial plants; Mathematical models; anthropogenic factors; Urban areas; Atmospheric pollution models; Air quality models; Numerical simulations; Urban atmospheric pollution; Mesoscale models; Industrial atmospheric pollution; Atmospheric transport DO - http://dx.doi.org/10.1016/j.apm.2007.05.002 ER - TY - JOUR T1 - The Deep Archaeal Roots of Eukaryotes AN - 19654522; 8422862 AB - The set of conserved eukaryotic protein-coding genes includes distinct subsets one of which appears to be most closely related to and, by inference, derived from archaea, whereas another one appears to be of bacterial, possibly, endosymbiotic origin. The 'archaeal' genes of eukaryotes, primarily, encode components of information-processing systems, whereas the 'bacterial' genes are predominantly operational. The precise nature of the archaeo-eukaryotic relationship remains uncertain, and it has been variously argued that eukaryotic informational genes evolved from the homologous genes of Euryarchaeota or Crenarchaeota (the major branches of extant archaea) or that the origin of eukaryotes lies outside the known diversity of archaea. We describe a comprehensive set of 355 eukaryotic genes of apparent archaeal origin identified through ortholog detection and phylogenetic analysis. Phylogenetic hypothesis testing using constrained trees, combined with a systematic search for shared derived characters in the form of homologous inserts in conserved proteins, indicate that, for the majority of these genes, the preferred tree topology is one with the eukaryotic branch placed outside the extant diversity of archaea although small subsets of genes show crenarchaeal and euryarchaeal affinities. Thus, the archaeal genes in eukaryotes appear to descend from a distinct, ancient, and otherwise uncharacterized archaeal lineage that acquired some euryarchaeal and crenarchaeal genes via early horizontal gene transfer. JF - Molecular Biology and Evolution AU - Yutin, Natalya AU - Makarova, Kira S AU - Mekhedov, Sergey L AU - Wolf, Yuri I AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, koonin@ncbi.nlm.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1619 EP - 1630 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 8 SN - 0737-4038, 0737-4038 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - archaea KW - eukaryotes KW - Euryarchaeota KW - Crenarchaeota KW - phylogenetic analysis KW - Phylogeny KW - Archaea KW - Information processing KW - Roots KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19654522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biology+and+Evolution&rft.atitle=The+Deep+Archaeal+Roots+of+Eukaryotes&rft.au=Yutin%2C+Natalya%3BMakarova%2C+Kira+S%3BMekhedov%2C+Sergey+L%3BWolf%2C+Yuri+I%3BKoonin%2C+Eugene+V&rft.aulast=Yutin&rft.aufirst=Natalya&rft.date=2008-08-01&rft.volume=25&rft.issue=8&rft.spage=1619&rft.isbn=&rft.btitle=&rft.title=Molecular+Biology+and+Evolution&rft.issn=07374038&rft_id=info:doi/10.1093%2Fmolbev%2Fmsn108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; Information processing; Roots; Crenarchaeota; Archaea; Euryarchaeota DO - http://dx.doi.org/10.1093/molbev/msn108 ER - TY - JOUR T1 - The Role of Infectious Agents in the Etiology of Ocular Adnexal Neoplasia AN - 19620625; 8748936 AB - Given the fact that infectious agents contribute to around 18% of human cancers worldwide, it would seem prudent to explore their role in neoplasms of the ocular adnexa: primary malignancies of the conjunctiva, lacrimal glands, eyelids, and orbit. By elucidating the mechanisms by which infectious agents contribute to oncogenesis, the management, treatment, and prevention of these neoplasms may one day parallel what is already in place for cancers such as cervical cancer, hepatocellular carcinoma, gastric mucosa-associated lymphoid tissue lymphoma and gastric adenocar-cinoma. Antibiotic treatment and vaccines against infectious agents may herald a future with a curtailed role for traditional therapies of surgery, radiation, and chemotherapy. Unlike other malignancies for which large epidemiological studies are available, analyzing ocular adnexal neoplasms is challenging as they are relatively rare. Additionally, putative infectious agents seemingly display an immense geographic variation that has led to much debate regarding the relative importance of one organism versus another. This review discusses the pathogenetic role of several microorganisms in different ocular adnexal malignancies, including human papilloma virus in conjunctival papilloma and squamous cell carcinoma, human immunodeficiency virus in conjunctival squamous carcinoma, Kaposi sarcoma-associated herpes virus or human herpes simplex virus-8 (KSHV/HHV-8) in conjunctival Kaposi sarcoma, Helicobacter pylori (H. pylori,), Chlamydia, and hepatitis C virus in ocular adnexal mucosa-associated lymphoid tissue lymphomas. Unlike cervical cancer where a single infectious agent, human papilloma virus, is found in greater than 99% of lesions, multiple organisms may play a role in the etiology of certain ocular adnexal neoplasms by acting through similar mechanisms of oncogenesis, including chronic antigenic stimulation and the action of infectious oncogenes. However, similar to other human malignancies, ultimately the role of infectious agents in ocular adnexal neoplasms is most likely as a cofactor to genetic and environmental risk factors. JF - Survey of Ophthalmology AU - Verma, V AU - Shen, D AU - Sieving, P C AU - Chan, C-C AD - Immunopathology Section, Laboratory of Immunology, National Eye Institute, Bethesda, Maryland, USA Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 312 EP - 331 VL - 53 IS - 4 SN - 0039-6257, 0039-6257 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; CSA Neurosciences Abstracts KW - Helicobacter pylori KW - Herpesvirus KW - Human herpesvirus 8 KW - Chemotherapy KW - Cervical cancer KW - Conjunctiva KW - Antibiotics KW - Herpes simplex KW - Neoplasia KW - Malignancy KW - Oncogenes KW - Radiation KW - Risk factors KW - Surgery KW - Geographical variations KW - Lymphoma KW - Chlamydia KW - Hepatocellular carcinoma KW - Eyelid KW - Etiology KW - Tumorigenesis KW - Kaposi's sarcoma-associated herpesvirus KW - squamous cell carcinoma KW - Lacrimal gland KW - Cofactors KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Reviews KW - Microorganisms KW - Sarcoma KW - Vaccines KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N3 11027:Neurology & neuropathology KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19620625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Survey+of+Ophthalmology&rft.atitle=The+Role+of+Infectious+Agents+in+the+Etiology+of+Ocular+Adnexal+Neoplasia&rft.au=Verma%2C+V%3BShen%2C+D%3BSieving%2C+P+C%3BChan%2C+C-C&rft.aulast=Verma&rft.aufirst=V&rft.date=2008-08-01&rft.volume=53&rft.issue=4&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Survey+of+Ophthalmology&rft.issn=00396257&rft_id=info:doi/10.1016%2Fj.survophthal.2008.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Eyelid; Etiology; Chemotherapy; Tumorigenesis; Cervical cancer; Conjunctiva; Antibiotics; squamous cell carcinoma; Herpes simplex; Neoplasia; Lacrimal gland; Malignancy; Cofactors; Oncogenes; Radiation; Surgery; Risk factors; Reviews; Sarcoma; Microorganisms; Geographical variations; Vaccines; Lymphoma; Hepatocellular carcinoma; Helicobacter pylori; Hepatitis C virus; Human immunodeficiency virus; Human herpesvirus 8; Herpesvirus; Kaposi's sarcoma-associated herpesvirus; Chlamydia DO - http://dx.doi.org/10.1016/j.survophthal.2008.04.008 ER - TY - JOUR T1 - At the Tipping Point: Predicting Severe Mobility Difficulty in Vulnerable Older Women AN - 19601276; 8531717 AB - OBJECTIVESTo identify clinical measures that aid detection of impending severe mobility difficulty in older women. DESIGNCross-sectional and longitudinal cohort study. SETTINGUrban community in Baltimore, Maryland. PARTICIPANTSOne thousand two community-dwelling, moderate to severely disabled women aged 65 and older in the Women's Health and Aging Study I. MEASUREMENTSSelf-report and performance measures representing six domains necessary for mobility: central and peripheral nervous systems, muscles, bones and joints, perception, and energy. Severe mobility difficulty was defined as usual gait of 0.5ms or less, any reported difficulty walking across a small room, or dependence on a walking aid during a 4-m walking test. RESULTSFour hundred sixty-seven out of 984 (47%) had severe mobility difficulty at baseline, and 104-474 (22%) developed it within 12 months. Baseline mobility difficulty was correlated with poor vision, knee pain, feelings of helplessness, inability to stand with feet side by side for 10 seconds, difficulty keeping balance while dressing or walking, inability to rise from a chair five times, and cognitive impairment. Of these, knee pain (odds ratio (OR)=1.74, 95% confidence interval (CI)=1.05-2.89), helplessness (OR=1.87, 95% CI=1.10-3.24), poor vision (OR=2.03, 95% CI=1.06-3.89), inability to rise from a chair five times (OR=2.50, 95% CI=1.15-5.41), and cognitive impairment (OR=4.75, 95% CI=1.67-13.48) predicted incident severe mobility difficulty within 12 months, independent of age. CONCLUSIONFive simple measures may aid identification of disabled older women at high risk of severe mobility difficulty. Further studies should determine generalizability to men and higher-functioning individuals. JF - Journal of the American Geriatrics Society AU - Rivera, Josette A AU - Fried, Linda P AU - Weiss, Carlos O AU - Simonsick, Eleanor M AD - Division of Geriatric Medicine and Gerontology and Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, Maryland, SimonsickEl@grc.nia.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1417 EP - 1423 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 56 IS - 8 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Age KW - Mobility KW - peripheral nervous system KW - Muscles KW - pain KW - USA, Maryland, Baltimore KW - Perception KW - Vision KW - Females KW - aging KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19601276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=At+the+Tipping+Point%3A+Predicting+Severe+Mobility+Difficulty+in+Vulnerable+Older+Women&rft.au=Rivera%2C+Josette+A%3BFried%2C+Linda+P%3BWeiss%2C+Carlos+O%3BSimonsick%2C+Eleanor+M&rft.aulast=Rivera&rft.aufirst=Josette&rft.date=2008-08-01&rft.volume=56&rft.issue=8&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2008.01819.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA, Maryland, Baltimore; Mobility; pain; Vision; Muscles; Perception; Females; aging; peripheral nervous system; Age DO - http://dx.doi.org/10.1111/j.1532-5415.2008.01819.x ER - TY - JOUR T1 - Blood supply safety: an NHLBI perspective AN - 19582973; 8487485 JF - Transfusion AU - Glynn, Simone A AD - NHLBI, DBDR Bethesda, MD e-mail: Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 1541 EP - 1544 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 48 IS - 8 SN - 0041-1132, 0041-1132 KW - Health & Safety Science Abstracts KW - Blood KW - Quality control KW - Public health KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19582973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Blood+supply+safety%3A+an+NHLBI+perspective&rft.au=Glynn%2C+Simone+A&rft.aulast=Glynn&rft.aufirst=Simone&rft.date=2008-08-01&rft.volume=48&rft.issue=8&rft.spage=1541&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2007.01754.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Blood; Public health; Quality control DO - http://dx.doi.org/10.1111/j.1537-2995.2007.01754.x ER - TY - JOUR T1 - Relationship Between Exposure, Clinical Malaria, and Age in an Area of Changing Transmission Intensity AN - 19559390; 8761995 AB - The relationship between malaria transmission intensity and clinical disease is important for predicting the outcome of control measures mat reduce transmission. Comparisons of hospital data between areas of differing transmission intensity suggest that the mean age of hospitalized clinical malaria is higher under relatively lower transmission, but the total number of episodes is similar until transmission drops below a threshold, where the risks of hospitalized malaria decline. These observations have rarely been examined longitudinally in a single community where transmission declines over time. We reconstructed 16 years (1991-2006) of pediatric hospital surveillance data and infection prevalence surveys from a circumscribed geographic area on the Kenyan coast The incidence of clinical malaria remained high, despite sustained reductions in exposure to infection. However, the age group experiencing the clinical attacks of malaria increased steadily as exposure declined and may precede changes in the number of episodes in an area with declining transmission. JF - American Journal of Tropical Medicine and Hygiene AU - O'Meara, W P AU - Mwangi, T W AU - Williams, T N AU - McKenzie, F E AU - Snow, R W AU - Marsh, K AD - Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 185 EP - 191 VL - 79 IS - 2 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Biological surveys KW - Age KW - Human diseases KW - Data processing KW - Pediatrics KW - Disease control KW - Malaria KW - Infection KW - Public health KW - Disease transmission KW - Age groups KW - Hygiene KW - Hospitals KW - Coasts KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19559390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Relationship+Between+Exposure%2C+Clinical+Malaria%2C+and+Age+in+an+Area+of+Changing+Transmission+Intensity&rft.au=O%27Meara%2C+W+P%3BMwangi%2C+T+W%3BWilliams%2C+T+N%3BMcKenzie%2C+F+E%3BSnow%2C+R+W%3BMarsh%2C+K&rft.aulast=O%27Meara&rft.aufirst=W&rft.date=2008-08-01&rft.volume=79&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Biological surveys; Human diseases; Disease control; Age groups; Malaria; Hygiene; Disease transmission; Public health; Age; Data processing; Pediatrics; Infection; Coasts; Hospitals ER - TY - JOUR T1 - Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A sub(2A) adenosine receptor homodimer AN - 19332700; 8685854 AB - The theoretical possibility of bivalent binding of a dendrimer, covalently appended with multiple copies of a small ligand, to a homodimer of a G protein-coupled receptor was investigated with a molecular modeling approach. A molecular model was constructed of a third generation (G3) poly(amidoamine) (PAMAM) dendrimer condensed with multiple copies of the potent A sub(2A) adenosine receptor agonist CGS21680. The dendrimer was bound to an A sub(2A) adenosine receptor homodimer. Two units of the nucleoside CGS21680 could occupy the A sub(2A) receptor homodimer simultaneously. The binding mode of CGS21680 moieties linked to the PAMAM dendrimer and docked to the A sub(2A) receptor was found to be similar to the binding mode of a monomeric CGS21680 ligand. JF - Bioorganic and Medicinal Chemistry AU - Ivanov, Andrei A AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, kajacobs@helix.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 4312 EP - 4315 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 15 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Adenosine receptors KW - double prime G protein-coupled receptors KW - nucleosides KW - Adenosine A2A receptors KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19332700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Molecular+modeling+of+a+PAMAM-CGS21680+dendrimer+bound+to+an+A+sub%282A%29+adenosine+receptor+homodimer&rft.au=Ivanov%2C+Andrei+A%3BJacobson%2C+Kenneth+A&rft.aulast=Ivanov&rft.aufirst=Andrei&rft.date=2008-08-01&rft.volume=18&rft.issue=15&rft.spage=4312&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2008.06.087 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; double prime G protein-coupled receptors; Adenosine receptors; nucleosides; Adenosine A2A receptors DO - http://dx.doi.org/10.1016/j.bmcl.2008.06.087 ER - TY - JOUR T1 - Lung, liver and bone cancer mortality in Mayak workers AN - 19312165; 8367801 AB - Workers at the Mayak nuclear facility in the Russian Federation offer the only adequate human data for evaluating cancer risks from exposure to plutonium. Risks of mortality from cancers of the lung, liver and bone, the organs receiving the largest doses from plutonium, were evaluated in a cohort of 17,740 workers initially hired 1948-1972 using, for the first time, recently improved individual organ dose estimates. Excess relative risk (ERR) models were used to evaluate risks as functions of internal (plutonium) dose, external (primarily gamma) dose, gender, attained age and smoking. By December 31, 2003, 681 lung cancer deaths, 75 liver cancer deaths and 30 bone cancer deaths had occurred. Of these 786 deaths, 239 (30%) were attributed to plutonium exposure. Significant plutonium dose-response relationships (p < 0.001) were observed for all 3 endpoints, with lung and liver cancer risks reasonably described by linear functions. At attained age 60, the ERRs per Gy for lung cancer were 7.1 for males and 15 for females; the averaged-attained age ERRs for liver cancer were 2.6 and 29 for males and females, respectively; those for bone cancer were 0.76 and 3.4. This study is the first to present and compare dose-response analyses for cancers of all 3 organs. The unique Mayak cohort with its high exposures and well characterized doses has allowed quantification of the plutonium dose-response for lung, liver and bone cancer risks based on direct human data. These results will play an important role in plutonium risk assessment. JF - International Journal of Cancer AU - Sokolnikov, Mikhail E AU - Gilbert, Ethel S AU - Preston, Dale L AU - Ron, Elaine AU - Shilnikova, Natalia S AU - Khokhryakov, Victor V AU - Vasilenko, Evgeny K AU - Koshurnikova, Nina A AD - Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk Region, Russian Federation, gilberte@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 905 EP - 911 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 4 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Bone cancer KW - Age KW - Liver cancer KW - Models KW - Smoking KW - Workers KW - Dose-response effects KW - Occupational exposure KW - Lung cancer KW - Mortality KW - Data processing KW - Plutonium KW - Organs KW - Cancer KW - Bone KW - Gender KW - Liver KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19312165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Lung%2C+liver+and+bone+cancer+mortality+in+Mayak+workers&rft.au=Sokolnikov%2C+Mikhail+E%3BGilbert%2C+Ethel+S%3BPreston%2C+Dale+L%3BRon%2C+Elaine%3BShilnikova%2C+Natalia+S%3BKhokhryakov%2C+Victor+V%3BVasilenko%2C+Evgeny+K%3BKoshurnikova%2C+Nina+A&rft.aulast=Sokolnikov&rft.aufirst=Mikhail&rft.date=2008-08-01&rft.volume=123&rft.issue=4&rft.spage=905&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23581 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Bone cancer; Mortality; Age; Plutonium; Data processing; Liver cancer; Models; Workers; Smoking; Dose-response effects; Occupational exposure; Lung cancer; Organs; Cancer; Bone; Gender; Liver DO - http://dx.doi.org/10.1002/ijc.23581 ER - TY - JOUR T1 - Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain AN - 19308966; 8379581 AB - (+/-)-3,4-Methylenedioxymethamphetmine (MDMA, or Ecstasy) is an illicit drug that evokes transporter-mediated release of monoamines, including serotonin (5-HT) and dopamine (DA). Here we monitored the effects of MDMA on neurochemistry and motor activity in rats, as a means to evaluate relationships between 5-HT, DA, and behavior. Male rats undergoing in vivo microdialysis were housed in chambers equipped with photobeams for measurement of ambulation (i.e., forward locomotion) and stereotypy (i.e., head weaving and forepaw treading). Microdialysis probes were placed into the n. accumbens, striatum or prefrontal cortex in separate groups of rats. Dialysate samples were assayed for 5-HT and DA by microbore HPLC-ECD. Rats received two i.v. injections of MDMA, 1 mg/kg followed by 3 mg/kg 60 min later; neurochemical and locomotor parameters were measured concurrently. MDMA produced dose-related elevations in extracellular 5-HT and DA in all regions, with the magnitude of 5-HT release always exceeding that of DA release. MDMA-induced ambulation was positively correlated with dialysate DA levels in all regions (P<0.05-0.0001) and with dialysate 5-HT in striatum and cortex (P<0.001-0.0001). Stereotypy was strongly correlated with dialysate 5-HT in all areas (P<0.001-0.0001) and with dialysate DA in accumbens and striatum (P<0.001-0.0001). These data support previous work and suggest the complex spectrum of behaviors produced by MDMA involves 5-HT and DA in a region- and modality-specific manner. JF - Pharmacology Biochemistry and Behavior AU - Baumann, M H AU - Clark, R D AU - Rothman, R B AD - Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), United States, mbaumann@mail.nih.gov Y1 - 2008/08// PY - 2008 DA - Aug 2008 SP - 208 EP - 217 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 90 IS - 2 SN - 0091-3057, 0091-3057 KW - CSA Neurosciences Abstracts; Animal Behavior Abstracts; Toxicology Abstracts KW - Nucleus accumbens KW - monoamines KW - Data processing KW - Head KW - Brain KW - Probes KW - Neurochemistry KW - Drug abuse KW - MDMA KW - Serotonin KW - Stereotyped behavior KW - Microdialysis KW - Dopamine KW - Locomotion KW - Motor activity KW - Neostriatum KW - Cortex (prefrontal) KW - X 24310:Pharmaceuticals KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25080:Orientation, Migration and Locomotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19308966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Locomotor+stimulation+produced+by+3%2C4-methylenedioxymethamphetamine+%28MDMA%29+is+correlated+with+dialysate+levels+of+serotonin+and+dopamine+in+rat+brain&rft.au=Baumann%2C+M+H%3BClark%2C+R+D%3BRothman%2C+R+B&rft.aulast=Baumann&rft.aufirst=M&rft.date=2008-08-01&rft.volume=90&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2Fj.pbb.2008.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nucleus accumbens; monoamines; Data processing; Head; Probes; Brain; Neurochemistry; Drug abuse; MDMA; Serotonin; Stereotyped behavior; Microdialysis; Dopamine; Locomotion; Motor activity; Neostriatum; Cortex (prefrontal) DO - http://dx.doi.org/10.1016/j.pbb.2008.02.018 ER - TY - JOUR T1 - Identification of novel markers for liver fibrosis in HIV/hepatitis C virus coinfected individuals using genomics-based approach AN - 19552761; 8397595 AB - Objective: The degree of liver fibrosis is a determinant for initiation of therapy for hepatitis C virus. Liver biopsy is invasive, risky and costly, but is required to assess fibrosis. This study intended to identify novel noninvasive markers to accurately assess fibrosis in HIV/hepatitis C virus coinfection. Methods: Using 100 biopsies from 68 HIV/hepatitis C virus coinfected patients, we developed a predictive model consisting of six serum markers along with age and antiretroviral therapy experience. DNA microarray analysis of peripheral blood mono-nuclear cells associated with a subset of 51 biopsies obtained from 28 patients was performed and incorporated into a second model. Results: The eight-marker model yielded an area under the receiver operating characteristic curve of 0.904. Combined analysis of clinical and DNA microarray data in the 51-biopsy subset identified two genes (alanine amino peptidase-N and mitogen-activated protein kinase kinase-3) that predicted fibrosis with high significance. The four-marker model that included the two genes and two serum markers had an area under the receiver operating characteristic curve of 0.852, which did not differ significantly from the eight-marker model on this subset (area under the receiver operating characteristic curve = 0.856, P = 0.96). Conclusion: Both models accurately predicted fibrosis with an accuracy of 87.9%, thereby sparing 83% of patients from obtaining a biopsy. DNA microarray analysis can be invaluable in identifying novel biomarkers of liver fibrosis. JF - AIDS AU - Suzman, DL AU - McLaughlin, M AU - Hu, Z AU - Kleiner, DE AU - Wood, B AU - Lempicki, R A AU - Mican, J M AU - Suffredini, A AU - Masur, H AU - Polis, MA AU - Kottilil, S AD - Building 10 - Magnuson CC, 11N204 10 Center Dr, Bethesda, MD, USA, skottilil@niaid.nih.gov Y1 - 2008/07/31/ PY - 2008 DA - 2008 Jul 31 SP - 1433 EP - 1439 VL - 22 IS - 12 SN - 0269-9370, 0269-9370 KW - Genetics Abstracts; Immunology Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - Bioindicators KW - Acquired immune deficiency syndrome KW - MAP kinase KW - Age KW - Data processing KW - Alanine KW - Fibrosis KW - antiretroviral therapy KW - Biopsy KW - Peripheral blood KW - DNA microarrays KW - biomarkers KW - Hepatitis KW - Hepatitis C virus KW - Human immunodeficiency virus KW - antiretroviral agents KW - DNA KW - Liver KW - Proteins KW - V 22360:AIDS and HIV KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19552761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Identification+of+novel+markers+for+liver+fibrosis+in+HIV%2Fhepatitis+C+virus+coinfected+individuals+using+genomics-based+approach&rft.au=Suzman%2C+DL%3BMcLaughlin%2C+M%3BHu%2C+Z%3BKleiner%2C+DE%3BWood%2C+B%3BLempicki%2C+R+A%3BMican%2C+J+M%3BSuffredini%2C+A%3BMasur%2C+H%3BPolis%2C+MA%3BKottilil%2C+S&rft.aulast=Suzman&rft.aufirst=DL&rft.date=2008-07-31&rft.volume=22&rft.issue=12&rft.spage=1433&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; MAP kinase; Data processing; Alanine; Fibrosis; antiretroviral therapy; Liver; Peripheral blood; Biopsy; biomarkers; DNA microarrays; Bioindicators; Hepatitis; Acquired immune deficiency syndrome; antiretroviral agents; DNA; Proteins; Hepatitis C virus; Human immunodeficiency virus ER - TY - JOUR T1 - Early indicators of exposure to biological threat agents using host gene profiles in peripheral blood mononuclear cells. AN - 69582572; 18667072 AB - Effective prophylaxis and treatment for infections caused by biological threat agents (BTA) rely upon early diagnosis and rapid initiation of therapy. Most methods for identifying pathogens in body fluids and tissues require that the pathogen proliferate to detectable and dangerous levels, thereby delaying diagnosis and treatment, especially during the prelatent stages when symptoms for most BTA are indistinguishable flu-like signs. To detect exposures to the various pathogens more rapidly, especially during these early stages, we evaluated a suite of host responses to biological threat agents using global gene expression profiling on complementary DNA arrays. We found that certain gene expression patterns were unique to each pathogen and that other gene changes occurred in response to multiple agents, perhaps relating to the eventual course of illness. Nonhuman primates were exposed to some pathogens and the in vitro and in vivo findings were compared. We found major gene expression changes at the earliest times tested post exposure to aerosolized B. anthracis spores and 30 min post exposure to a bacterial toxin. Host gene expression patterns have the potential to serve as diagnostic markers or predict the course of impending illness and may lead to new stage-appropriate therapeutic strategies to ameliorate the devastating effects of exposure to biothreat agents. JF - BMC infectious diseases AU - Das, Rina AU - Hammamieh, Rasha AU - Neill, Roger AU - Ludwig, George V AU - Eker, Steven AU - Lincoln, Patrick AU - Ramamoorthy, Preveen AU - Dhokalia, Apsara AU - Mani, Sachin AU - Mendis, Chanaka AU - Cummings, Christiano AU - Kearney, Brian AU - Royaee, Atabak AU - Huang, Xiao-Zhe AU - Paranavitana, Chrysanthi AU - Smith, Leonard AU - Peel, Sheila AU - Kanesa-Thasan, Niranjan AU - Hoover, David AU - Lindler, Luther E AU - Yang, David AU - Henchal, Erik AU - Jett, Marti AD - Division of Pathology, Walter Reed Army Institute of Research, Silver Spring, MD, USA. dasr2@nhlbi.nih.gov Y1 - 2008/07/30/ PY - 2008 DA - 2008 Jul 30 SP - 104 VL - 8 KW - Biological Warfare Agents KW - 0 KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Analysis of Variance KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Principal Component Analysis KW - Gene Expression KW - Reverse Transcriptase Polymerase Chain Reaction KW - Anthrax -- genetics KW - Environmental Exposure KW - Macaca mulatta KW - Time Factors KW - RNA -- genetics KW - Leukocytes, Mononuclear -- immunology KW - Bacillus anthracis -- immunology KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69582572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+infectious+diseases&rft.atitle=Early+indicators+of+exposure+to+biological+threat+agents+using+host+gene+profiles+in+peripheral+blood+mononuclear+cells.&rft.au=Das%2C+Rina%3BHammamieh%2C+Rasha%3BNeill%2C+Roger%3BLudwig%2C+George+V%3BEker%2C+Steven%3BLincoln%2C+Patrick%3BRamamoorthy%2C+Preveen%3BDhokalia%2C+Apsara%3BMani%2C+Sachin%3BMendis%2C+Chanaka%3BCummings%2C+Christiano%3BKearney%2C+Brian%3BRoyaee%2C+Atabak%3BHuang%2C+Xiao-Zhe%3BParanavitana%2C+Chrysanthi%3BSmith%2C+Leonard%3BPeel%2C+Sheila%3BKanesa-Thasan%2C+Niranjan%3BHoover%2C+David%3BLindler%2C+Luther+E%3BYang%2C+David%3BHenchal%2C+Erik%3BJett%2C+Marti&rft.aulast=Das&rft.aufirst=Rina&rft.date=2008-07-30&rft.volume=8&rft.issue=&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=BMC+infectious+diseases&rft.issn=1471-2334&rft_id=info:doi/10.1186%2F1471-2334-8-104 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-06 N1 - Date created - 2008-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 2000 Jan;68(1):342-51 [10603407] Genes Immun. 2007 Jun;8(4):308-19 [17429414] JAMA. 2000 May 3;283(17):2281-90 [10807389] Pharmacology. 2000 Jul;61(1):11-3 [10895075] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8778-83 [10922034] Curr Clin Top Infect Dis. 2000;20:335-49 [10943532] Biochem J. 2000 Dec 15;352 Pt 3:739-45 [11104681] Cell Calcium. 2000 Sep;28(3):161-9 [11020378] Curr Opin Microbiol. 2001 Feb;4(1):78-81 [11173038] Am J Pathol. 2001 Apr;158(4):1231-7 [11290540] Mod Pathol. 2001 May;14(5):482-95 [11353060] J Biomed Sci. 2001 Sep;8(5):377-88 [11549879] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74 [11553815] Clin Lab Med. 2001 Sep;21(3):661-78 [11572145] Science. 2001 Oct 26;294(5543):870-5 [11679675] Nature. 2001 Nov 8;414(6860):160-1 [11700539] Ann Otol Rhinol Laryngol. 2001 Nov;110(11):1045-50 [11713916] J Biol Chem. 2001 Nov 30;276(48):44435-43 [11579087] Emerg Infect Dis. 2001 Nov-Dec;7(6):933-44 [11747719] Clin Diagn Lab Immunol. 2002 Jan;9(1):19-27 [11777824] Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):972-7 [11805339] Nucleic Acids Res. 2002 Feb 15;30(4):e15 [11842121] Am J Clin Pathol. 2002 Feb;117(2):205-9 [11863216] Cancer Res. 2002 Jun 15;62(12):3466-76 [12067990] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1896-901 [12578971] J Clin Microbiol. 2003 Jul;41(7):3273-83 [12843075] Infect Immun. 2004 Nov;72(11):6382-9 [15501768] Am J Pathol. 1974 Apr;75(1):171-80 [4825613] Infect Immun. 1985 Jan;47(1):234-41 [3965398] J Infect Dis. 1989 Oct;160(4):706-10 [2507648] Biochem Biophys Res Commun. 1994 Mar 15;199(2):676-82 [8135809] Infect Immun. 1994 Oct;62(10):4432-9 [7927706] Annu Rev Physiol. 1996;58:143-70 [8815789] Adv Exp Med Biol. 1997;419:315-20 [9193671] JAMA. 1997 Aug 6;278(5):399-411 [9244332] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] Biosens Bioelectron. 2004 Nov 1;20(4):719-27 [15522586] Exp Biol Med (Maywood). 2004 Nov;229(10):1061-71 [15522843] J Immunol. 2006 Nov 1;177(9):6497-503 [17056582] J Virol. 2000 Jan;74(2):914-22 [10623754] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2334-8-104 ER - TY - JOUR T1 - Amphetamine causes dopamine depletion and cell death in the mouse olfactory bulb. AN - 69353846; 18544452 AB - Amphetamine is a neurotoxic psychostimulant that causes dopamine depletion and neuronal death in the rodent striatum. In the present study, we sought to determine if toxic doses of the drug can also induce pathological changes in the mouse olfactory bulb. We found that injections of amphetamine (10 mg/kg x 4, given 2 h apart) caused significant decreases in dopamine levels in that structure. This dose of the drug also induced substantial increases in the number of terminal deoxynucleotidyl transferase-mediated deoxyribonucleotide triphosphate (dNTP) nick end labeling (TUNEL)-positive cells in the olfactory bulb indicative of elevated DNA fragmentation. These results show that the toxic effects of amphetamine involve the olfactory bulb in addition to the striatum. These observations need to be taken into consideration when discussing the clinical course of amphetamine addiction. JF - European journal of pharmacology AU - Atianjoh, Fidelis E AU - Ladenheim, Bruce AU - Krasnova, Irina N AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, NIH/DHHS, Baltimore, MD 21224, USA. Y1 - 2008/07/28/ PY - 2008 DA - 2008 Jul 28 SP - 94 EP - 97 VL - 589 IS - 1-3 SN - 0014-2999, 0014-2999 KW - Central Nervous System Stimulants KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - In Situ Nick-End Labeling KW - Animals KW - Drug Administration Schedule KW - Down-Regulation KW - Mice KW - Injections KW - Cell Death -- drug effects KW - Time Factors KW - Male KW - Olfactory Bulb -- pathology KW - Central Nervous System Stimulants -- toxicity KW - Amphetamine -- toxicity KW - Olfactory Bulb -- drug effects KW - Amphetamine -- administration & dosage KW - Dopamine -- metabolism KW - Central Nervous System Stimulants -- administration & dosage KW - Olfactory Bulb -- metabolism KW - DNA Fragmentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69353846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Amphetamine+causes+dopamine+depletion+and+cell+death+in+the+mouse+olfactory+bulb.&rft.au=Atianjoh%2C+Fidelis+E%3BLadenheim%2C+Bruce%3BKrasnova%2C+Irina+N%3BCadet%2C+Jean+Lud&rft.aulast=Atianjoh&rft.aufirst=Fidelis&rft.date=2008-07-28&rft.volume=589&rft.issue=1-3&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/10.1016%2Fj.ejphar.2008.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-24 N1 - Date created - 2008-07-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2000 Aug;23(2):113-26 [10882838] FASEB J. 2005 May;19(7):851-3 [15731293] J Psychiatr Res. 2001 Sep-Oct;35(5):271-7 [11591429] Neuroscience. 2001;107(2):265-74 [11731100] Brain Res. 2002 Dec 20;958(1):52-69 [12468030] Psychopharmacology (Berl). 2003 Feb;165(4):359-69 [12491026] Mov Disord. 2003 Apr;18(4):364-72 [12671941] J Neurophysiol. 2003 Jul;90(1):395-404 [12611989] Psychopharmacology (Berl). 2003 Nov;170(2):150-6 [12774190] Mov Disord. 2004 Jun;19(6):687-92 [15197709] Neurology. 1980 May;30(5):547-50 [6768005] Brain Res. 1980 Jul 7;193(1):153-63 [7378814] J Neurocytol. 1981 Apr;10(2):251-9 [6118395] Eur J Pharmacol. 1985 Oct 8;116(1-2):11-6 [2414113] Brain Res. 1990 Jun 4;518(1-2):67-77 [1975218] Psychiatry Clin Neurosci. 1996 Oct;50(5):271-5 [9201790] Life Sci. 1997;61(22):2219-29 [9393941] Drug Alcohol Depend. 1997 Dec 15;48(3):235-42 [9449023] Neuroscience. 1998 Aug;85(3):969-77 [9639288] Neuropsychopharmacology. 1999 Apr;20(4):322-39 [10088133] J Neurophysiol. 1999 Aug;82(2):1082-5 [10444702] Neuroscience. 2000;95(1):113-7 [10619467] Neurosci Biobehav Rev. 2005;29(4-5):627-47 [15925697] Physiol Behav. 2005 May 19;85(1):45-56 [15924905] Nat Rev Neurosci. 2006 Mar;7(3):179-93 [16495940] Pharmacotherapy. 2006 Oct;26(10):1501-10 [16999660] Annu Rev Pharmacol Toxicol. 2007;47:681-98 [17209801] Neurotox Res. 2007 Jan;11(1):1-32 [17449445] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] Drug Alcohol Rev. 2007 May;26(3):279-85 [17454017] Biol Psychiatry. 2007 Jun 1;61(11):1235-43 [17161385] Traffic Inj Prev. 2007 Dec;8(4):361-7 [17994489] Mol Pharmacol. 2000 Dec;58(6):1247-56 [11093760] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ejphar.2008.05.001 ER - TY - JOUR T1 - Mapping prefrontal circuits in vivo with manganese-enhanced magnetic resonance imaging in monkeys. AN - 69347078; 18650340 AB - Manganese-enhanced magnetic resonance imaging (MEMRI) provides a powerful tool to study multisynaptic circuits in vivo and thereby to link information about neural structure and function within individual subjects. Making the best use of MEMRI in monkeys requires minimizing manganese-associated neurotoxicity, maintaining sensitivity to manganese-dependent signal changes and mapping transport throughout the brain without a priori anatomical hypotheses. Here, we performed intracortical injections of isotonic MnCl(2), comparisons of preinjection and postinjection scans, and voxelwise statistical mapping. Isotonic MnCl(2) did not cause cell death at the injection site, damage to downstream targets of manganese transport, behavioral deficits, or changes in neuronal responsiveness. We detected and mapped manganese transport throughout cortical-subcortical circuits by using voxelwise statistical comparisons of at least 10 preinjection and two postinjection scans. We were able to differentiate between focal and diffuse projection fields and to distinguish between the topography of striatal projections from orbitofrontal and anterior cingulate cortex in a single animal. This MEMRI approach provides a basis for combining circuit-based anatomical analyses with simultaneous single-unit recordings and/or functional magnetic resonance imaging in individual monkeys. Such studies will enhance our interpretations of functional data and our understanding of how neuronal activity is transformed as it propagates through a circuit. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Simmons, Janine M AU - Saad, Ziad S AU - Lizak, Martin J AU - Ortiz, Michael AU - Koretsky, Alan P AU - Richmond, Barry J AD - Department of Health and Human Services, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-4415, USA. Y1 - 2008/07/23/ PY - 2008 DA - 2008 Jul 23 SP - 7637 EP - 7647 VL - 28 IS - 30 KW - Manganese KW - 42Z2K6ZL8P KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Action Potentials -- physiology KW - Animals KW - Conditioning, Classical -- physiology KW - Neural Pathways -- physiology KW - Action Potentials -- drug effects KW - Haplorhini KW - Photic Stimulation -- methods KW - Neural Pathways -- blood supply KW - Oxygen -- blood KW - Neural Pathways -- anatomy & histology KW - Time Factors KW - Image Processing, Computer-Assisted KW - Female KW - Male KW - Magnetic Resonance Imaging KW - Manganese -- pharmacology KW - Brain Mapping KW - Prefrontal Cortex -- anatomy & histology KW - Prefrontal Cortex -- physiology KW - Prefrontal Cortex -- blood supply KW - Image Enhancement -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69347078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Mapping+prefrontal+circuits+in+vivo+with+manganese-enhanced+magnetic+resonance+imaging+in+monkeys.&rft.au=Simmons%2C+Janine+M%3BSaad%2C+Ziad+S%3BLizak%2C+Martin+J%3BOrtiz%2C+Michael%3BKoretsky%2C+Alan+P%3BRichmond%2C+Barry+J&rft.aulast=Simmons&rft.aufirst=Janine&rft.date=2008-07-23&rft.volume=28&rft.issue=30&rft.spage=7637&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.1488-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-07-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurophysiol. 2000 Apr;83(4):1864-76 [10758098] J Cereb Blood Flow Metab. 2008 Apr;28(4):832-40 [17987047] J Neurosci Methods. 2000 Nov 15;103(1):63-71 [11074096] Magn Reson Med. 2001 Sep;46(3):424-9 [11550231] Neuroscience. 2002;112(2):467-74 [12044464] Neuron. 2002 May 30;34(5):685-700 [12062017] Magn Reson Med. 2003 Jul;50(1):33-9 [12815676] Neuroimage. 2003 Nov;20(3):1591-600 [14642470] Magn Reson Med. 2004 Jan;51(1):22-6 [14705041] Neuroimage. 2004 Mar;21(3):914-23 [15006658] Exp Brain Res. 1983;49(1):93-115 [6861938] J Neurosci. 1985 Mar;5(3):776-94 [2983048] Arch Toxicol. 1987;61(1):46-52 [3439874] Arch Toxicol. 1992;66(5):359-64 [1319135] Science. 1993 Feb 5;259(5096):819-21 [7679223] Exp Neurol. 1993 Mar;120(1):89-94 [8477830] J Neurochem. 1994 Jan;62(1):205-16 [7505311] Brain Res. 1994 Sep 19;657(1-2):124-32 [7820609] J Comp Neurol. 1994 Dec 15;350(3):337-56 [7533796] Magn Reson Med. 1995 May;33(5):636-47 [7596267] J Neurosci. 1995 Jul;15(7 Pt 1):4851-67 [7623116] J Neurosci. 1995 Sep;15(9):5999-6013 [7666184] Neurology. 1996 Feb;46(2):492-8 [8614520] Comput Biomed Res. 1996 Jun;29(3):162-73 [8812068] NMR Biomed. 1997 Jun-Aug;10(4-5):171-8 [9430344] Magn Reson Med. 1998 Nov;40(5):740-8 [9797158] Neurotoxicology. 1999 Apr-Jun;20(2-3):227-38 [10385886] NMR Biomed. 2004 Dec;17(8):532-43 [15617052] NMR Biomed. 2004 Dec;17(8):554-68 [15617054] NMR Biomed. 2004 Dec;17(8):595-601 [15761948] Magn Reson Med. 2006 Mar;55(3):604-11 [16470592] Magn Reson Imaging. 2006 May;24(4):349-58 [16677940] J Neurosci. 2006 Aug 9;26(32):8368-76 [16899732] Cereb Cortex. 2008 Jan;18(1):93-103 [17434918] Neuroimage. 2008 Apr 1;40(2):458-72 [18222710] J Comp Neurol. 2000 Sep 25;425(3):447-70 [10972944] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1523/JNEUROSCI.1488-08.2008 ER - TY - JOUR T1 - Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression. AN - 69322027; 18578507 AB - The transcriptional activity of steroid hormones is intimately associated with their structure. Deacylcortivazol (DAC) contains several features that were predicted to make it an inactive glucocorticoid. Nevertheless, gene induction and repression by complexes of glucocorticoid receptor (GR) with DAC occur with potency (lower EC 50) greater than and efficacy (maximal activity, or A max) equal to those of the very active and smaller synthetic glucocorticoid dexamethasone (Dex). Guided by a recent X-ray structure of DAC bound to the GR ligand binding domain (LBD), we now report that several point mutants in the LBD have little effect on the binding of either agonist steroid. However, these same mutations dramatically alter the A max and/or EC 50 of exogenous and endogenous genes in a manner that depends on steroid structure. In some cases, Dex is no longer a full agonist. These properties appear to result from a preferential inactivation of the AF2 activation domain in the GR LBD of Dex-bound, but not DAC-bound, receptors. The Dex-bound receptors display normal binding to, but a greatly reduced response to, the coactivator TIF2, thus indicating a defect in the transmission efficiency of GR-steroid complex information to the coactivator TIF2. In addition, all GR mutants that are active in gene induction with either Dex or DAC have greatly reduced activity in gene repression. This contrasts with the reports of GR mutations preferentially suppressing GR-mediated induction. The properties of these GR mutants in gene induction support the hypothesis that the A max and EC 50 of GR-controlled gene expression can be independently modified, indicate that the receptor can be modified to favor activity with a specific agonist steroid, and suggest that new ligands with suitable substituents may be able to affect the same LBD conformational changes and thereby broaden the therapeutic applications of glucocorticoid steroids. JF - Biochemistry AU - Tao, Yong-guang AU - Xu, Yong AU - Xu, H Eric AU - Simons, S Stoney AD - Steroid Hormones Section, National Institute of Diabetes and Digestive and Kidney Diseases/Clinical Endocrinology Branch, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/07/22/ PY - 2008 DA - 2008 Jul 22 SP - 7648 EP - 7662 VL - 47 IS - 29 KW - Nuclear Receptor Coactivator 2 KW - 0 KW - Pregnatrienes KW - Receptors, Glucocorticoid KW - Steroids KW - deacylcortivazol KW - 3JO09QT49F KW - Dexamethasone KW - 7S5I7G3JQL KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - COS Cells KW - Humans KW - Pregnatrienes -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Dexamethasone -- chemistry KW - Structure-Activity Relationship KW - Mutagenesis, Site-Directed KW - Blotting, Western KW - Dexamethasone -- metabolism KW - Nuclear Receptor Coactivator 2 -- pharmacology KW - Protein Binding -- drug effects KW - Cercopithecus aethiops KW - Pregnatrienes -- chemistry KW - Protein Structure, Tertiary KW - Cell Line KW - Receptors, Glucocorticoid -- chemistry KW - Point Mutation KW - Receptors, Glucocorticoid -- metabolism KW - Receptors, Glucocorticoid -- genetics KW - Steroids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69322027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Mutations+of+glucocorticoid+receptor+differentially+affect+AF2+domain+activity+in+a+steroid-selective+manner+to+alter+the+potency+and+efficacy+of+gene+induction+and+repression.&rft.au=Tao%2C+Yong-guang%3BXu%2C+Yong%3BXu%2C+H+Eric%3BSimons%2C+S+Stoney&rft.aulast=Tao&rft.aufirst=Yong-guang&rft.date=2008-07-22&rft.volume=47&rft.issue=29&rft.spage=7648&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=1520-4995&rft_id=info:doi/10.1021%2Fbi800472w LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-03 N1 - Date created - 2008-07-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 1999 Nov;13(11):1855-63 [10551779] Proc Natl Acad Sci U S A. 1990 May;87(10):3977-81 [2160080] Mol Endocrinol. 1999 Dec;13(12):2108-21 [10598585] Mol Cell Endocrinol. 1999 Dec 20;158(1-2):117-30 [10630412] Mol Endocrinol. 2000 Jul;14(7):1010-27 [10894151] J Mol Biol. 2000 Aug 25;301(4):947-58 [10966797] Nature. 2000 Sep 21;407(6802):395-401 [11014197] J Biol Chem. 2001 Apr 27;276(17):13615-21 [11278408] EMBO J. 1994 Sep 1;13(17):4087-95 [8076604] Vitam Horm. 1994;49:49-130 [7810076] Mol Cell Biol. 1995 Feb;15(2):1005-13 [7823916] Mol Cell Biol. 1997 Jun;17(6):3181-93 [9154817] Mol Endocrinol. 1997 Jul;11(8):1156-64 [9212062] Mol Endocrinol. 1997 Aug;11(9):1245-55 [9259316] EMBO J. 1997 Aug 1;16(15):4698-707 [9303314] Nature. 1997 Oct 16;389(6652):753-8 [9338790] Cell. 1998 May 15;93(4):531-41 [9604929] Nature. 1998 May 28;393(6683):392-6 [9620806] Cell. 1998 Dec 23;95(7):927-37 [9875847] J Steroid Biochem Mol Biol. 1999 Feb;68(3-4):89-102 [10369406] Mol Cell Biol. 1999 Jul;19(7):5036-49 [10373553] Mol Cell. 2004 Dec 22;16(6):929-41 [15610736] Mol Endocrinol. 2005 Feb;19(2):290-311 [15539428] Biochemistry. 2005 Mar 8;44(9):3547-61 [15736964] Mol Endocrinol. 2005 Jun;19(6):1483-500 [15774497] Science. 2005 May 27;308(5726):1318-21 [15919995] Curr Top Med Chem. 2006;6(3):271-85 [16515481] Genes Dev. 2006 Mar 15;20(6):689-99 [16543221] Biochemistry. 2006 Jun 27;45(25):7693-9 [16784220] J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):3-17 [16723222] Mol Cell Biol. 2007 Feb;27(4):1467-85 [17116691] RNA. 2007 Apr;13(4):563-72 [17307815] Proc Natl Acad Sci U S A. 2007 May 15;104(20):8311-5 [17494761] Biochemistry. 2007 Jul 10;46(27):8036-49 [17571860] J Biol Chem. 2007 Aug 10;282(32):23231-9 [17556356] EMBO J. 2007 Aug 8;26(15):3534-44 [17627277] Mol Cell Biol. 2008 Mar;28(6):1915-23 [18160712] Nat Struct Biol. 2002 May;9(5):359-64 [11953755] J Clin Endocrinol Metab. 2002 Jun;87(6):2658-67 [12050230] Cell. 2002 Jul 12;110(1):93-105 [12151000] J Biol Chem. 2002 Dec 20;277(51):49256-66 [12376547] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16701-6 [12481024] Mol Endocrinol. 2003 May;17(5):845-59 [12569182] Trends Pharmacol Sci. 2003 May;24(5):253-9 [12767725] J Biol Chem. 2003 Jun 20;278(25):22748-54 [12686538] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13845-50 [14617768] Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):227-32 [14694204] Cell. 2004 Feb 6;116(3):417-29 [15016376] J Med Chem. 2004 May 6;47(10):2441-52 [15115388] Mol Endocrinol. 2004 Jun;18(6):1376-95 [15016838] J Mol Biol. 1970 Aug 28;52(1):57-74 [4395012] J Biol Chem. 2001 Jan 26;276(4):2329-32 [11106637] J Biol Chem. 2001 Jul 6;276(27):24806-16 [11333273] EMBO J. 2001 Nov 1;20(21):6071-83 [11689447] J Biol Chem. 2002 Apr 12;277(15):12541-9 [11812797] J Steroid Biochem. 1977 Sep;8(9):911-9 [199797] Biochem Biophys Res Commun. 1979 Feb 14;86(3):792-800 [426822] J Steroid Biochem. 1981 Mar;14(3):273-9 [6111624] Genes Dev. 1989 Oct;3(10):1590-601 [2515114] J Biol Chem. 1999 Dec 17;274(51):36527-36 [10593951] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/bi800472w ER - TY - JOUR T1 - Discriminatory Accuracy From Single-Nucleotide Polymorphisms in Models to Predict Breast Cancer Risk AN - 20732154; 8422829 AB - One purpose for seeking common alleles that are associated with disease is to use them to improve models for projecting individualized disease risk. Two genome-wide association studies and a study of candidate genes recently identified seven common single-nucleotide polymorphisms (SNPs) that were associated with breast cancer risk in independent samples. These seven SNPs were located in FGFR2, TNRC9 (now known as TOX3), MAP3K1, LSP1, CASP8, chromosomal region 8q, and chromosomal region 2q35. I used estimates of relative risks and allele frequencies from these studies to estimate how much these SNPs could improve discriminatory accuracy measured as the area under the receiver operating characteristic curve (AUC). A model with these seven SNPs (AUC = 0.574) and a hypothetical model with 14 such SNPs (AUC = 0.604) have less discriminatory accuracy than a model, the National Cancer Institute's Breast Cancer Risk Assessment Tool (BCRAT), that is based on ages at menarche and at first live birth, family history of breast cancer, and history of breast biopsy examinations (AUC = 0.607). Adding the seven SNPs to BCRAT improved discriminatory accuracy to an AUC of 0.632, which was, however, less than the improvement from adding mammographic density. Thus, these seven common alleles provide less discriminatory accuracy than BCRAT but have the potential to improve the discriminatory accuracy of BCRAT modestly. Experience to date and quantitative arguments indicate that a huge increase in the numbers of case patients with breast cancer and control subjects would be required in genome-wide association studies to find enough SNPs to achieve high discriminatory accuracy. JF - Journal of the National Cancer Institute AU - Gail, Mitchell H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, gailm@mail.nih.gov Y1 - 2008/07/16/ PY - 2008 DA - 2008 Jul 16 SP - 1037 EP - 1041 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 14 SN - 0027-8874, 0027-8874 KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts KW - Risk assessment KW - Historical account KW - Age KW - Mammography KW - Fibroblast growth factor receptor 2 KW - Biopsy KW - Models KW - Genetics KW - Single-nucleotide polymorphism KW - Menarche KW - Breast cancer KW - Gene frequency KW - R2 23060:Medical and environmental health KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20732154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Discriminatory+Accuracy+From+Single-Nucleotide+Polymorphisms+in+Models+to+Predict+Breast+Cancer+Risk&rft.au=Gail%2C+Mitchell+H&rft.aulast=Gail&rft.aufirst=Mitchell&rft.date=2008-07-16&rft.volume=100&rft.issue=14&rft.spage=1037&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn180 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Age; Mammography; Fibroblast growth factor receptor 2; Single-nucleotide polymorphism; Menarche; Breast cancer; Gene frequency; Biopsy; Models; Genetics; Historical account DO - http://dx.doi.org/10.1093/jnci/djn180 ER - TY - JOUR T1 - Computed Tomography Screening for Lung Cancer in a High-Risk Population: Update on Current Status AN - 19900108; 8422835 JF - Journal of the National Cancer Institute AU - Russo, Patrizia AU - Paleari, Laura AU - Granone, Pierluigi AU - Cesario, Alfredo AU - Pastorino, Ugo AD - Affiliations of authors: Lung Cancer Unit, National Cancer Research Institute, Genoa, Italy (PR, LP); Thoracic Surgery Unit, Catholic University, Rome, Italy (PG, AC); Respiratory Unit, Istituto di Ricovero e Cura a Carattere Scientifico 'San Raffaele,' Rome, Italy (AC); Thoracic Surgery Unit, National Cancer Institute, Milan, Italy (UP), patrizia.russo@istge.it Y1 - 2008/07/16/ PY - 2008 DA - 2008 Jul 16 SP - 1043 EP - 1044 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 14 SN - 0027-8874, 0027-8874 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Risk groups KW - Lung cancer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19900108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Computed+Tomography+Screening+for+Lung+Cancer+in+a+High-Risk+Population%3A+Update+on+Current+Status&rft.au=Russo%2C+Patrizia%3BPaleari%2C+Laura%3BGranone%2C+Pierluigi%3BCesario%2C+Alfredo%3BPastorino%2C+Ugo&rft.aulast=Russo&rft.aufirst=Patrizia&rft.date=2008-07-16&rft.volume=100&rft.issue=14&rft.spage=1043&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn203 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computed tomography; Risk groups; Lung cancer DO - http://dx.doi.org/10.1093/jnci/djn203 ER - TY - JOUR T1 - Novel progranulin mutation: screening for PGRN mutations in a Portuguese series of FTD/CBS cases. AN - 742778788; pmid-18464284 AB - Mutations in the progranulin (PGRN) gene were recently described as the cause of ubiquitin positive frontotemporal dementia (FTD) in many families. Different frequencies of these genetic changes have been reported in diverse populations leading us to determine if these mutations were a major cause of FTD in the Portuguese population. The entire coding sequence plus exon 0 of PGRN were sequenced in a consecutive series of 46 FTD/CBS Portuguese patients. Two mutations were found: a novel pathogenic insertion (p.Gln300GlnfsX61) and a previously described point variant (p.T182M) of unclear pathogenicity. Pathogenic mutations in the PGRN gene were found in one of the 36 probands studied (3% of the probands in our series) who had a corticobasal syndrome presentation, indicating that in the Portuguese population, mutations in this gene are not a major cause of FTD. (c) 2008 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Guerreiro, Rita Joao AU - Santana, Isabel AU - Bras, Jose Miguel AU - Revesz, Tamas AU - Rebelo, Olinda AU - Ribeiro, Maria Helena AU - Santiago, Beatriz AU - Oliveira, Catarina Resende AU - Singleton, Andrew AU - Hardy, John AD - Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Center, Bethesda, Maryland 20852, USA. portalegrer@nia.nih.gov Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 1269 EP - 1273 VL - 23 IS - 9 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - DNA Mutational Analysis KW - Humans KW - Middle Aged KW - Family Health KW - Female KW - Male KW - DNA-Binding Proteins -- metabolism KW - Portugal -- epidemiology KW - Intercellular Signaling Peptides and Proteins -- genetics KW - Dementia -- genetics KW - Mutation -- genetics KW - Dementia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742778788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Novel+progranulin+mutation%3A+screening+for+PGRN+mutations+in+a+Portuguese+series+of+FTD%2FCBS+cases.&rft.au=Guerreiro%2C+Rita+Joao%3BSantana%2C+Isabel%3BBras%2C+Jose+Miguel%3BRevesz%2C+Tamas%3BRebelo%2C+Olinda%3BRibeiro%2C+Maria+Helena%3BSantiago%2C+Beatriz%3BOliveira%2C+Catarina+Resende%3BSingleton%2C+Andrew%3BHardy%2C+John&rft.aulast=Guerreiro&rft.aufirst=Rita&rft.date=2008-07-15&rft.volume=23&rft.issue=9&rft.spage=1269&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - High-dose interleukin-2 for the treatment of metastatic renal cell carcinoma : a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006. AN - 69321630; 18457330 AB - The treatment of metastatic renal cell carcinoma (RCC) with high-dose interleukin-2 (HD IL-2) has resulted in durable tumor regression in a minority of patients. The current study presents the authors' 20-year experience administering this immunotherapeutic agent. Patients with metastatic RCC (n = 259) were treated with HD IL-2 alone from January 13, 1986 through December 31, 2006 at the Surgery Branch of the National Cancer Institute. Potential predictive factors for response and survival, both pretreatment and treatment-related, were first subjected to univariate analysis and then to multivariate logistic regression or a Cox proportional hazards model. Finally, the authors investigated Memorial Sloan-Kettering Cancer Center (MSKCC) prognostic factors for survival to assess their predictive value in the patient population in the current study. A total of 23 patients experienced a complete response and 30 patients achieved a partial response, for an overall objective response rate of 20%. All partial responders had developed disease recurrence at the time of last follow-up, but only 4 complete responders had experienced disease recurrence by that time. Despite toxicities, only 2 patients developed treatment-related mortalities over this same time period. A higher baseline weight (P = .05) and MSKCC prognostic factors (P = .02) were found to be the variables most associated with response. For survival >4 years and overall survival, several pretreatment and treatment-related factors maintained significance, but none more so than response (P < .0001). HD IL-2 can induce complete tumor regression in a small number of patients, and many patients have experienced extended disease-free intervals. Given its relative safety, HD IL-2 should still be considered a first-line therapy in patients with metastatic RCC who have an overall good performance status. JF - Cancer AU - Klapper, Jacob A AU - Downey, Stephanie G AU - Smith, Franz O AU - Yang, James C AU - Hughes, Marybeth S AU - Kammula, Udai S AU - Sherry, Richard M AU - Royal, Richard E AU - Steinberg, Seth M AU - Rosenberg, Steven AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 293 EP - 301 VL - 113 IS - 2 SN - 0008-543X, 0008-543X KW - Indoleacetic Acids KW - 0 KW - Interleukin-2 KW - prodolic acid KW - U8EX2DRD73 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Survival Rate KW - National Cancer Institute (U.S.) KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Interleukin-2 -- adverse effects KW - Carcinoma, Renal Cell -- surgery KW - Interleukin-2 -- therapeutic use KW - Carcinoma, Renal Cell -- secondary KW - Carcinoma, Renal Cell -- drug therapy KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69321630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=High-dose+interleukin-2+for+the+treatment+of+metastatic+renal+cell+carcinoma+%3A+a+retrospective+analysis+of+response+and+survival+in+patients+treated+in+the+surgery+branch+at+the+National+Cancer+Institute+between+1986+and+2006.&rft.au=Klapper%2C+Jacob+A%3BDowney%2C+Stephanie+G%3BSmith%2C+Franz+O%3BYang%2C+James+C%3BHughes%2C+Marybeth+S%3BKammula%2C+Udai+S%3BSherry%2C+Richard+M%3BRoyal%2C+Richard+E%3BSteinberg%2C+Seth+M%3BRosenberg%2C+Steven&rft.aulast=Klapper&rft.aufirst=Jacob&rft.date=2008-07-15&rft.volume=113&rft.issue=2&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.23552 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-28 N1 - Date created - 2008-07-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Aug;17(8):2530-40 [10561319] N Engl J Med. 2007 May 31;356(22):2271-81 [17538086] Clin Cancer Res. 2003 Feb;9(2):802-11 [12576453] J Clin Oncol. 2003 Aug 15;21(16):3127-32 [12915604] Cancer. 1981 Jan 1;47(1):207-14 [7459811] Ann Surg. 1989 Oct;210(4):474-84; discussion 484-5 [2679456] J Clin Oncol. 1989 Dec;7(12):1863-74 [2685181] J Clin Oncol. 1990 Jan;8(1):161-9 [2404087] J Clin Oncol. 1992 Jul;10(7):1119-23 [1607917] Ann Oncol. 1992 Jun;3(6):475-80 [1498066] J Natl Cancer Inst. 1993 Apr 21;85(8):622-32 [8468720] J Clin Oncol. 1993 Apr;11(4):661-70 [8478661] J Clin Oncol. 1993 Sep;11(9):1809-16 [8355047] J Clin Oncol. 1995 Feb;13(2):497-501 [7844611] J Clin Oncol. 1995 Mar;13(3):688-96 [7884429] Cancer. 1995 Aug 15;76(4):687-94 [8625167] Ann Surg. 1998 Sep;228(3):307-19 [9742914] Clin Cancer Res. 2005 May 15;11(10):3714-21 [15897568] J Immunother. 2005 Sep-Oct;28(5):488-95 [16113605] Cancer J Sci Am. 1996 Mar-Apr;2(2):91-8 [9166506] N Engl J Med. 2007 Jan 11;356(2):115-24 [17215529] N Engl J Med. 2007 Jan 11;356(2):125-34 [17215530] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.23552 ER - TY - JOUR T1 - ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel. AN - 69313884; 18628469 AB - Polymorphisms that are associated with ABCB1 expression and function may be linked to treatment efficacy and the development of neutropenia and neurotoxicity in patients with androgen-independent prostate cancer receiving docetaxel. Patients with androgen-independent prostate cancer treated with docetaxel alone (n = 23) or docetaxel and thalidomide (n = 50) were genotyped for the ABCB1 1236C>T, 2677 G>T/A, and 3435 C>T alleles by direct sequencing, and diplotypes were constructed using an EM algorithm. The data were then compared with duration to onset of peripheral neuropathy, neutropenia grade, and survival after docetaxel. For patients receiving docetaxel alone, individuals carrying a diplotype consisting of the 1236C-2677G-3435C linked alleles had improved overall survival after treatment (P = 0.0017). Additionally, patients treated with docetaxel and thalidomide carrying a diplotype consisting of the 2677T-3435T haplotype had a shorter median survival (P = 0.045). After adjusting for a particular set of polymorphisms and diplotype groupings, a hazard ratio of 10.87 was found for patients carrying the 2677GG genotype versus patients carrying other genotypes (P = 0.0048) in the docetaxel and thalidomide cohort. Among both treatment arms together, individuals carrying the 2677GG genotype also had a significantly longer time to neuropathy (P = 0.035). Finally, there was a strong trend toward patients carrying the 2677TT-3435TT diplotype having higher grades of neutropenia (P = 0.053). The data suggest that docetaxel-induced neuropathy, neutropenia grade, and overall survival could be linked to ABCB1 allelic variants with ensuing negative implications for docetaxel treatment in patients carrying ABCB1 variant genotypes. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Sissung, Tristan M AU - Baum, Caitlin E AU - Deeken, John AU - Price, Douglas K AU - Aragon-Ching, Jeanny AU - Steinberg, Seth M AU - Dahut, William AU - Sparreboom, Alex AU - Figg, William D AD - Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 4543 EP - 4549 VL - 14 IS - 14 SN - 1078-0432, 1078-0432 KW - ABCB1 protein, human KW - 0 KW - Androgens KW - Antineoplastic Agents KW - P-Glycoprotein KW - P-Glycoproteins KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - Thalidomide KW - 4Z8R6ORS6L KW - Index Medicus KW - Kaplan-Meier Estimate KW - Genotype KW - Polymerase Chain Reaction KW - Gene Frequency KW - Humans KW - Drug Resistance, Neoplasm -- genetics KW - Thalidomide -- therapeutic use KW - Male KW - Androgens -- metabolism KW - Taxoids -- pharmacokinetics KW - Prostatic Neoplasms -- mortality KW - P-Glycoprotein -- genetics KW - Polymorphism, Genetic KW - Antineoplastic Agents -- pharmacokinetics KW - Prostatic Neoplasms -- genetics KW - Taxoids -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69313884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=ABCB1+genetic+variation+influences+the+toxicity+and+clinical+outcome+of+patients+with+androgen-independent+prostate+cancer+treated+with+docetaxel.&rft.au=Sissung%2C+Tristan+M%3BBaum%2C+Caitlin+E%3BDeeken%2C+John%3BPrice%2C+Douglas+K%3BAragon-Ching%2C+Jeanny%3BSteinberg%2C+Seth+M%3BDahut%2C+William%3BSparreboom%2C+Alex%3BFigg%2C+William+D&rft.aulast=Sissung&rft.aufirst=Tristan&rft.date=2008-07-15&rft.volume=14&rft.issue=14&rft.spage=4543&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4230 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-16 N1 - Date created - 2008-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Jpn J Cancer Res. 1999 Dec;90(12):1380-6 [10665657] Cancer Chemother Rep. 1966 Mar;50(3):163-70 [5910392] Muscle Nerve. 2001 Aug;24(8):1050-7 [11439380] Acta Otolaryngol. 2001 Sep;121(6):735-42 [11678173] Eur J Cancer. 2002 Mar;38(4):497-504 [11872341] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Proc Natl Acad Sci U S A. 1987 Nov;84(21):7735-8 [2444983] Proc Natl Acad Sci U S A. 1989 Jan;86(2):695-8 [2563168] Cell. 1991 Jul 12;66(1):85-94 [1712673] Blood. 1992 Dec 1;80(11):2729-34 [1360266] Cancer Treat Rev. 1993 Oct;19(4):351-86 [8106152] Cell. 1994 May 20;77(4):491-502 [7910522] J Chromatogr B Biomed Sci Appl. 1997 Jun 6;693(2):437-41 [9210450] Neurosci Lett. 1997 Aug 22;232(1):41-4 [9292887] Recent Results Cancer Res. 1998;144:93-115 [9304712] Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):854-9 [16467099] Cancer Chemother Pharmacol. 2006 May;57(5):599-606 [16136308] J Clin Pharmacol. 2006 Mar;46(3):373-9 [16490813] Clin Pharmacol Ther. 2006 Jun;79(6):570-80 [16765145] Clin Cancer Res. 2006 Jul 1;12(13):4127; author reply 4127-9 [16818714] Clin Cancer Res. 2006 Oct 1;12(19):5786-93 [17020985] Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6204 [17062699] Eur J Cancer. 2006 Nov;42(17):2893-6 [16950614] Pharmacogenet Genomics. 2006 Dec;16(12):855-61 [17108809] Science. 2007 Jan 26;315(5811):525-8 [17185560] Expert Opin Pharmacother. 2007 Feb;8(2):119-27 [17257083] Clin Cancer Res. 2008 Jun 1;14(11):3312-8 [18519758] BJU Int. 2008 Aug 5;102(5):617-21 [18537956] Prostate. 2004 Apr 1;59(1):77-90 [14991868] Clin Pharmacokinet. 2004;43(9):553-76 [15217301] J Clin Oncol. 2004 Jul 1;22(13):2532-9 [15226321] N Engl J Med. 2004 Oct 7;351(15):1502-12 [15470213] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3473-8 [10716719] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4230 ER - TY - JOUR T1 - Invited commentary: is monitoring of human papillomavirus infection for viral persistence ready for use in cervical cancer screening? AN - 69299059; 18483124 AB - Persistent cervical infections by approximately 15 carcinogenic genotypes of human papillomavirus (HPV) cause virtually all cases of cervical cancer and its immediate precancerous precursor, cervical intraepithelial neoplasia grade 3 or carcinoma in situ. As is shown in a meta-analysis by Koshiol et al. (Am J Epidemiol 2008;168:123-137), detection of carcinogenic HPV viral persistence could be used to identify women at the greatest risk of cervical precancer. Specifically, women who have carcinogenic HPV infection that persists for at least 1 year versus those whose infections clear are at significantly elevated risk of having or developing cervical precancer. However, before detection of HPV persistence can be used in cervical cancer screening, several considerations need to be addressed: 1) validation and Food and Drug Administration approval of a reliable HPV genotyping test, 2) rational clinical algorithms based on risk of precancer and cancer for the clinical management of HPV persistence, 3) clinician and patient acceptability of monitoring of HPV infections (including not responding excessively to the first positive HPV test and waiting 1-2 years for infections to either persist or resolve), and 4) patient compliance with recommended follow-up. Investigators will need to address these and other key issues in order to realize the potential utility of HPV viral monitoring for improving the accuracy of cervical cancer screening. JF - American journal of epidemiology AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 138 EP - 44; discussion 145-8 VL - 168 IS - 2 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Human papillomavirus 18 -- genetics KW - Genotype KW - ROC Curve KW - Human papillomavirus 16 -- isolation & purification KW - Humans KW - Human papillomavirus 18 -- isolation & purification KW - Algorithms KW - Human papillomavirus 16 -- genetics KW - Female KW - Papillomavirus Infections -- diagnosis KW - Papillomavirus Infections -- complications KW - Papillomaviridae -- isolation & purification KW - Cervical Intraepithelial Neoplasia -- virology KW - Carcinoma, Squamous Cell -- virology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69299059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Invited+commentary%3A+is+monitoring+of+human+papillomavirus+infection+for+viral+persistence+ready+for+use+in+cervical+cancer+screening%3F&rft.au=Castle%2C+Philip+E&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-07-15&rft.volume=168&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-15 N1 - Date created - 2008-07-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 1999 Nov 25;341(22):1687-8 [10572158] N Engl J Med. 2007 May 10;356(19):1915-27 [17494925] JAMA. 2000 Jan 5;283(1):87-93 [10632285] JAMA. 2002 Oct 9;288(14):1749-57 [12365959] J Natl Cancer Inst. 2003 Jan 1;95(1):46-52 [12509400] N Engl J Med. 2003 Feb 6;348(6):489-90 [12571255] Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):485-90 [12814991] Am J Obstet Gynecol. 2003 Jun;188(6):1401-5 [12824969] Obstet Gynecol. 2004 Feb;103(2):304-9 [14754700] Obstet Gynecol. 2004 Apr;103(4):619-31 [15051550] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] J Infect Dis. 2007 Jul 1;196(1):76-81 [17538886] Obstet Gynecol. 2007 Jun;109(6):1325-31 [17540804] Lancet Infect Dis. 2007 Jul;7(7):453-9 [17597569] Lancet. 2007 Jun 30;369(9580):2161-70 [17602732] Diagn Cytopathol. 2007 Aug;35(8):463-4 [17636500] Am J Obstet Gynecol. 2007 Oct;197(4):340-5 [17904956] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] Am J Obstet Gynecol. 2007 Oct;197(4):356.e1-6 [17904958] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] J Clin Microbiol. 2008 Jan;46(1):109-17 [17989194] Am J Epidemiol. 2008 Jul 15;168(2):123-37 [18483125] Am J Epidemiol. 2004 May 1;159(9):882-90 [15105181] Am J Clin Pathol. 2004 Aug;122(2):238-45 [15323141] Am J Obstet Gynecol. 2004 Aug;191(2):430-4 [15343217] Obstet Gynecol. 1992 Mar;79(3):328-37 [1310805] IARC Sci Publ. 1992;(119):121-33 [1330905] J Infect Dis. 2005 Jun 1;191(11):1796-807 [15871111] J Infect Dis. 2005 Jun 1;191(11):1808-16 [15871112] Virology. 2005 Jun 20;337(1):76-84 [15914222] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Am J Clin Pathol. 2005 Nov;124(5):716-21 [16203283] Lancet. 2006 Feb 11;367(9509):489-98 [16473126] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] Obstet Gynecol. 2006 Aug;108(2):264-72 [16880294] Am J Obstet Gynecol. 2006 Aug;195(2):349-53 [16677597] Vaccine. 2006 Aug 31;24 Suppl 3:S3/78-89 [16950021] Vaccine. 2006 Aug 31;24 Suppl 3:S3/90-7 [16950022] Cancer Res. 2006 Oct 15;66(20):10112-9 [17047075] Cancer Res. 2006 Nov 1;66(21):10630-6 [17062559] Am J Clin Pathol. 2007 Mar;127(3):335-7 [17276947] Am J Clin Pathol. 2007 May;127(5):805-15 [17439841] J Infect Dis. 2007 Jun 1;195(11):1582-9 [17471427] Comment On: Am J Epidemiol. 2008 Jul 15;168(2):123-37 [18483125] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn037 ER - TY - JOUR T1 - Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis. AN - 69294172; 18483125 AB - Detection of persistent cervical carcinogenic human papillomavirus (HPV) DNA is used as a marker for cervical cancer risk in clinical trials. The authors performed a systematic review and meta-analysis of the association between persistent HPV DNA and high-grade cervical intraepithelial neoplasia (CIN2-3), high-grade squamous intraepithelial lesions (HSIL), and invasive cervical cancer (together designated CIN2-3/HSIL+) to evaluate the robustness of HPV persistence for clinical use. MEDLINE and Current Contents were searched through January 30, 2006. Relative risks (RRs) were stratified by HPV comparison group. Of 2,035 abstracts, 41 studies were eligible for inclusion in the meta-analysis. Over 22,500 women were included in calculation of RRs for persistent HPV DNA detection and cervical neoplasia. RRs ranged from 1.3 (95% confidence interval: 1.1, 1.5) to 813.0 (95% confidence interval: 168.2, 3,229.2) for CIN2-3/HSIL+ versus 12 months), wider testing intervals, CIN2-3/HSIL+, and use of an HPV-negative reference group were consistently associated with higher RRs. Thus, HPV persistence was consistently and strongly associated with CIN2-3/HSIL+, despite wide variation in definitions and study methods. The magnitude of association varied by duration of persistence and testing interval. Precise definition and standardization of HPV testing, sampling procedure, and test interval are needed for reliable clinical testing. These findings validate HPV persistence as a clinical marker and endpoint. JF - American journal of epidemiology AU - Koshiol, Jill AU - Lindsay, Lisa AU - Pimenta, Jeanne M AU - Poole, Charles AU - Jenkins, David AU - Smith, Jennifer S AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892-7236, USA. koshiolj@mail.nih.gov Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 123 EP - 137 VL - 168 IS - 2 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Risk KW - Human papillomavirus 16 -- isolation & purification KW - DNA, Viral -- analysis KW - Humans KW - Human papillomavirus 18 -- isolation & purification KW - Female KW - Papillomavirus Infections -- complications KW - Papillomaviridae -- isolation & purification KW - Cervical Intraepithelial Neoplasia -- virology KW - Papillomaviridae -- genetics KW - Carcinoma, Squamous Cell -- virology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69294172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Persistent+human+papillomavirus+infection+and+cervical+neoplasia%3A+a+systematic+review+and+meta-analysis.&rft.au=Koshiol%2C+Jill%3BLindsay%2C+Lisa%3BPimenta%2C+Jeanne+M%3BPoole%2C+Charles%3BJenkins%2C+David%3BSmith%2C+Jennifer+S&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2008-07-15&rft.volume=168&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn036 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-15 N1 - Date created - 2008-07-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 2005 Aug 10;116(1):122-9 [15751045] Int J Cancer. 2005 Aug 10;116(1):136-43 [15756677] Virology. 2005 Jun 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15;84(12):1616-23 [11401314] JAMA. 2001 Jun 20;285(23):2995-3002 [11410098] Lancet. 2001 Jun 9;357(9271):1831-6 [11410191] J Acquir Immune Defic Syndr. 2001 Aug 15;27(5):432-42 [11511819] J Infect Dis. 2001 Sep 15;184(6):682-90 [11517428] Int J Cancer. 2001 Sep15;93(6):817-22 [11519043] Gynecol Oncol. 2001 Nov;83(2):439-44 [11606114] JAMA. 2001 Dec 26;286(24):3106-14 [11754676] J Clin Microbiol. 2002 Mar;40(3):902-7 [11880413] J Clin Pathol. 2002 Apr;55(4):244-65 [11919208] JAMA. 2002 Apr 24;287(16):2120-9 [11966387] Anticancer Res. 2002 Mar-Apr;22(2B):1177-81 [12168921] J Infect Dis. 2002 Aug 15;186(4):462-9 [12195372] BMJ. 2002 Sep 14;325(7364):572 [12228133] Int J Cancer. 2002 Oct 20;101(6):526-31 [12237892] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] J Clin Pathol. 2005 Sep;58(9):946-50 [16126875] J Natl Cancer Inst. 2006 Jan 18;98(2):100-9 [16418512] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] JAMA. 2002 Oct 9;288(14):1749-57 [12365959] Am J Clin Pathol. 2002 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[15042650] Am J Epidemiol. 2004 May 1;159(9):834-42 [15105176] Obstet Gynecol. 2006 Aug;108(2):264-72 [16880294] Am J Obstet Gynecol. 2006 Aug;195(2):349-53 [16677597] Int J Cancer. 2006 Oct 1;119(7):1623-9 [16646070] Vaccine. 2006 Aug 31;24 Suppl 3:S3/42-51 [16950017] J Med Virol. 2005 Aug;76(4):576-82 [15977240] Vaccine. 2006 Aug 31;24 Suppl 3:S3/63-70 [16950019] BMJ. 2006 Dec 16;333(7581):1248 [17060338] Nat Rev Cancer. 2007 Jan;7(1):11-22 [17186016] J Infect Dis. 2007 Jun 1;195(11):1582-9 [17471427] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Ann Oncol. 2004 Jun;15(6):863-9 [15151941] J Infect Dis. 2004 Jul 1;190(1):46-52 [15195242] Br J Cancer. 2004 Aug 31;91(5):942-53 [15292939] J Infect Dis. 2004 Oct 15;190(8):1413-21 [15378433] Int J Cancer. 2004 Dec 10;112(5):854-9 [15386375] Int J Gynaecol Obstet. 2004 Nov;87(2):131-7 [15491557] J Clin Microbiol. 1991 Mar;29(3):573-7 [1645370] J Pediatr. 1992 Aug;121(2):307-11 [1322456] J Infect Dis. 1992 Nov;166(5):951-7 [1328408] N Engl J Med. 1992 Oct 29;327(18):1272-8 [1328880] Int J Gynecol Pathol. 1993 Apr;12(2):186-92 [8463044] J Infect Dis. 1994 Feb;169(2):235-40 [8106758] Biometrics. 1994 Dec;50(4):1088-101 [7786990] J Natl Cancer Inst. 1995 Sep 20;87(18):1365-71 [7658497] Int J Gynaecol Obstet. 1995 Oct;51(1):43-8 [8582517] J Clin Microbiol. 1997 Jun;35(6):1304-10 [9163434] BMJ. 1997 Sep 13;315(7109):629-34 [9310563] N Engl J Med. 1998 Feb 12;338(7):423-8 [9459645] J Pediatr. 1998 Feb;132(2):277-84 [9506641] Sex Transm Dis. 1998 May;25(5):243-50 [9587175] Stat Med. 1998 Apr 30;17(8):841-56 [9595615] Obstet Gynecol. 1998 Oct;92(4 Pt 2):727-35 [9764690] Obstet Gynecol. 1999 Jan;93(1):46-50 [9916955] J Natl Cancer Inst. 1999 Jun 2;91(11):954-60 [10359548] J Pathol. 1999 Sep;189(1):12-9 [10451482] J Infect Dis. 1999 Nov;180(5):1415-23 [10515798] Stat Med. 1999 Oct 30;18(20):2693-708 [10521860] Lancet. 2004 Nov 13-19;364(9447):1757-65 [15541448] J Med Virol. 2005 Feb;75(2):213-21 [15602735] J Infect Dis. 2005 Mar 1;191(5):731-8 [15688287] Comment In: Am J Epidemiol. 2008 Jul 15;168(2):138-44; discussion 145-8 [18483124] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn036 ER - TY - JOUR T1 - Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV. AN - 69281505; 18505381 AB - Injection drug users (IDUs) who successfully clear hepatitis C virus (HCV) have a reduced risk of developing chronic reinfection, despite their continuing exposure to the virus. To identify immunological correlates for this apparent protection, we studied HCV-specific immune responses in long-term IDUs (duration, >10 years). HCV-specific T cell responses were assessed in proliferation, enzyme-linked immunospot (ELISPOT), interferon (IFN)-gamma secretion, and cytotoxicity assays, whereas HCV-specific antibodies were assessed in enzyme immunoassays (EIAs), chemiluminescent assays, and in vitro neutralization assays. HCV-specific T cell proliferation and IFN-gamma production were more common in nonviremic EIA-positive IDUs (16 [94%] of 17 IDUs) than in viremic EIA-positive IDUs (9 [45%] of 20 IDUs) (P= .003). They were also noted in 16 (62%) of 26 nonviremic EIA-negative IDUs. In contrast, 19 (90%) of 21 viremic IDUs displayed neutralizing antibodies (nAbs), compared with 9 (56%) of 16 nonviremic EIA-positive IDUs (P= .04) and 0 of 24 nonviremic EIA-negative IDUs. Nonviremic IDUs with nAbs were older (P= .0115) than those without nAbs, but these groups did not differ in terms of either injection drug use duration or HCV-specific T cell responses. The reduced risk of HCV persistence in IDUs previously recovered from HCV infection correlated with T cell responses, and prolonged antigenic stimulation appears to be required to maintain humoral responses. JF - The Journal of infectious diseases AU - Mizukoshi, Eishiro AU - Eisenbach, Christoph AU - Edlin, Brian R AU - Newton, Kimberly P AU - Raghuraman, Sukanya AU - Weiler-Normann, Christina AU - Tobler, Leslie H AU - Busch, Michael P AU - Carrington, Mary AU - McKeating, Jane A AU - O'Brien, Thomas R AU - Rehermann, Barbara AD - Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda 20892, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 203 EP - 212 VL - 198 IS - 2 SN - 0022-1899, 0022-1899 KW - Cytokines KW - 0 KW - Viral Proteins KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Viral Proteins -- genetics KW - Humans KW - Cytokines -- secretion KW - Leukocytes, Mononuclear -- immunology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Risk Assessment KW - Genotype KW - Lymphocyte Activation KW - Cross-Sectional Studies KW - Leukocytes, Mononuclear -- virology KW - Viremia -- epidemiology KW - Incidence KW - Interferon-gamma -- blood KW - United States -- epidemiology KW - T-Lymphocytes -- immunology KW - Hepacivirus -- pathogenicity KW - Hepatitis C -- transmission KW - Hepacivirus -- genetics KW - Substance Abuse, Intravenous -- immunology KW - Hepatitis C -- epidemiology KW - Hepatitis C -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69281505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Hepatitis+C+virus+%28HCV%29-specific+immune+responses+of+long-term+injection+drug+users+frequently+exposed+to+HCV.&rft.au=Mizukoshi%2C+Eishiro%3BEisenbach%2C+Christoph%3BEdlin%2C+Brian+R%3BNewton%2C+Kimberly+P%3BRaghuraman%2C+Sukanya%3BWeiler-Normann%2C+Christina%3BTobler%2C+Leslie+H%3BBusch%2C+Michael+P%3BCarrington%2C+Mary%3BMcKeating%2C+Jane+A%3BO%27Brien%2C+Thomas+R%3BRehermann%2C+Barbara&rft.aulast=Mizukoshi&rft.aufirst=Eishiro&rft.date=2008-07-15&rft.volume=198&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F589510 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Semin Liver Dis. 2005 Feb;25(1):7-17 [15731994] J Clin Invest. 1998 Nov 1;102(9):1758-65 [9802890] J Clin Microbiol. 2005 May;43(5):2477-80 [15872288] Am J Trop Med Hyg. 2005 Jul;73(1):44-9 [16014830] Hepatology. 2006 Nov;44(5):1139-45 [17058216] Gastroenterology. 2007 Feb;132(2):667-78 [17258731] Gastroenterology. 2007 Feb;132(2):654-66 [17258733] Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6025-30 [17392433] Hepatology. 2007 Sep;46(3):666-71 [17657818] J Exp Med. 2000 May 1;191(9):1499-512 [10790425] Nat Med. 2000 May;6(5):578-82 [10802716] J Virol. 2001 Feb;75(3):1229-35 [11152496] Am J Public Health. 2001 Jan;91(1):46-7 [11189823] J Clin Invest. 2001 Feb;107(3):341-9 [11160158] Lancet. 2001 May 5;357(9266):1397-401 [11356437] Am J Public Health. 2002 Mar;92(3):385-7 [11867316] Lancet. 2002 Apr 27;359(9316):1478-83 [11988247] J Virol. 2002 Jun;76(12):6104-13 [12021343] J Exp Med. 2003 Mar 3;197(5):633-42 [12615904] J Infect Dis. 2003 Mar 15;187(6):974-81 [12660944] J Virol. 2003 Apr;77(8):4781-93 [12663785] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7271-6 [12761383] J Exp Med. 2003 Jun 16;197(12):1645-55 [12810686] Trends Immunol. 2003 Aug;24(8):456-64 [12909460] Science. 2003 Oct 24;302(5645):659-62 [14576438] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14199-204 [14617769] J Immunol. 2004 Jan 1;172(1):483-92 [14688358] J Virol. 2004 Feb;78(3):1575-81 [14722311] J Clin Microbiol. 2004 Feb;42(2):610-7 [14766824] Hepatology. 2004 Jul;40(1):87-97 [15239090] Hepatology. 2004 Jul;40(1):98-107 [15239091] Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10149-54 [15220475] Gastroenterology. 2004 Sep;127(3):924-36 [15362047] AIDS. 1988 Feb;2(1):55-60 [3128998] West J Med. 1992 Jan;156(1):30-5 [1310362] N Engl J Med. 1992 Dec 31;327(27):1899-905 [1280771] JAMA. 1994 Jan 12;271(2):115-20 [8264065] Medicine (Baltimore). 1995 Jul;74(4):212-20 [7623656] Lancet. 1995 Oct 14;346(8981):1006-7 [7475549] Am J Public Health. 1995 Nov;85(11):1531-7 [7485666] Am J Public Health. 1996 May;86(5):642-54 [8629714] NIDA Res Monogr. 1995;157:212-30 [8684438] J Infect Dis. 1997 Aug;176(2):518-22 [9237722] J Infect Dis. 1997 Oct;176(4):859-66 [9333142] Nature. 1998 Mar 5;392(6671):86-9 [9510252] Nat Rev Immunol. 2005 Mar;5(3):215-29 [15738952] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/589510 ER - TY - JOUR T1 - A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. AN - 69272915; 18397875 AB - Haploinsufficiency for the transcription factor SOX10 is associated with the pigmentary deficiencies of Waardenburg syndrome (WS) and is modeled in Sox10 haploinsufficient mice (Sox10(LacZ/+)). As genetic background affects WS severity in both humans and mice, we established an N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identify modifiers that increase the phenotypic severity of Sox10(LacZ/+) mice. Analysis of 230 pedigrees identified three modifiers, named modifier of Sox10 neurocristopathies (Mos1, Mos2 and Mos3). Linkage analysis confirmed their locations on mouse chromosomes 13, 4 and 3, respectively, within regions distinct from previously identified WS loci. Positional candidate analysis of Mos1 identified a truncation mutation in a hedgehog(HH)-signaling mediator, GLI-Kruppel family member 3 (Gli3). Complementation tests using a second allele of Gli3 (Gli3(Xt-J)) confirmed that a null mutation of Gli3 causes the increased hypopigmentation in Sox10(LacZ/+);Gli3(Mos1/)(+) double heterozygotes. Early melanoblast markers (Mitf, Sox10, Dct, and Si) are reduced in Gli3(Mos1/)(Mos1) embryos, indicating that loss of GLI3 signaling disrupts melanoblast specification. In contrast, mice expressing only the GLI3 repressor have normal melanoblast specification, indicating that the full-length GLI3 activator is not required for specification of neural crest to the melanocyte lineage. This study demonstrates the feasibility of sensitized screens to identify disease modifier loci and implicates GLI3 and other HH signaling components as modifiers of human neurocristopathies. JF - Human molecular genetics AU - Matera, Ivana AU - Watkins-Chow, Dawn E AU - Loftus, Stacie K AU - Hou, Ling AU - Incao, Arturo AU - Silver, Debra L AU - Rivas, Cecelia AU - Elliott, Eugene C AU - Baxter, Laura L AU - Pavan, William J AD - Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 2118 EP - 2131 VL - 17 IS - 14 KW - Codon, Nonsense KW - 0 KW - DNA-Binding Proteins KW - Gli3 protein, mouse KW - High Mobility Group Proteins KW - Kruppel-Like Transcription Factors KW - Mutagens KW - Nerve Tissue Proteins KW - Repressor Proteins KW - SOX10 protein, human KW - SOXE Transcription Factors KW - Sox10 protein, mouse KW - Transcription Factors KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Pigmentation KW - Animals KW - Melanocytes -- physiology KW - Humans KW - Repressor Proteins -- metabolism KW - Cell Differentiation KW - Mice KW - Mutagens -- pharmacology KW - Mice, Inbred BALB C KW - Embryo, Mammalian -- metabolism KW - Repressor Proteins -- genetics KW - Chromosome Mapping KW - Base Sequence KW - Mice, Inbred C57BL KW - Genetic Complementation Test KW - Embryo, Mammalian -- physiopathology KW - Male KW - Ethylnitrosourea -- pharmacology KW - Female KW - Gene Expression Regulation, Developmental -- drug effects KW - Transcription Factors -- metabolism KW - Waardenburg Syndrome -- embryology KW - Neural Crest -- physiopathology KW - DNA-Binding Proteins -- genetics KW - Nerve Tissue Proteins -- genetics KW - Waardenburg Syndrome -- metabolism KW - Transcription Factors -- genetics KW - Mutagenesis KW - Waardenburg Syndrome -- physiopathology KW - Neural Crest -- drug effects KW - High Mobility Group Proteins -- genetics KW - Neural Crest -- embryology KW - Nerve Tissue Proteins -- metabolism KW - Kruppel-Like Transcription Factors -- metabolism KW - High Mobility Group Proteins -- metabolism KW - Neural Crest -- metabolism KW - Waardenburg Syndrome -- genetics KW - Kruppel-Like Transcription Factors -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69272915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=A+sensitized+mutagenesis+screen+identifies+Gli3+as+a+modifier+of+Sox10+neurocristopathy.&rft.au=Matera%2C+Ivana%3BWatkins-Chow%2C+Dawn+E%3BLoftus%2C+Stacie+K%3BHou%2C+Ling%3BIncao%2C+Arturo%3BSilver%2C+Debra+L%3BRivas%2C+Cecelia%3BElliott%2C+Eugene+C%3BBaxter%2C+Laura+L%3BPavan%2C+William+J&rft.aulast=Matera&rft.aufirst=Ivana&rft.date=2008-07-15&rft.volume=17&rft.issue=14&rft.spage=2118&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=1460-2083&rft_id=info:doi/10.1093%2Fhmg%2Fddn110 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-07 N1 - Date created - 2008-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7159-63 [8041763] Nature. 1992 Feb 13;355(6361):637-8 [1347149] Nat Genet. 1994 Nov;8(3):251-5 [7874167] Nat Genet. 1996 Apr;12(4):442-4 [8630502] Nat Genet. 1996 Apr;12(4):445-7 [8630503] Nat Genet. 1997 Mar;15(3):266-8 [9054938] Development. 1997 Jul;124(13):2537-52 [9216996] Dev Biol. 1997 Dec 1;192(1):99-107 [9405100] Nat Genet. 1998 Jan;18(1):60-4 [9425902] Nat Genet. 1998 Feb;18(2):171-3 [9462749] Nature. 1998 Nov 26;396(6709):370-3 [9845073] J Biol Chem. 1999 Mar 19;274(12):8143-52 [10075717] Genome Res. 1999 Mar;9(3):215-25 [10077527] Hum Mol Genet. 1999 Sep;8(9):1769-77 [10441342] Trends Genet. 1999 Oct;15(10):418-25 [10498938] Am J Hum Genet. 2005 Apr;76(4):609-22 [15739154] Nat Rev Genet. 2005 Apr;6(4):271-86 [15803197] Pigment Cell Res. 2005 Jun;18(3):167-80 [15892713] Genes Brain Behav. 2006 Feb;5(1):19-28 [16436185] Mech Dev. 2006 Feb;123(2):124-34 [16412618] J Med Genet. 2006 Jun;43(6):465-9 [16740916] Dev Biol. 2006 Aug 15;296(2):396-408 [16857183] Adv Exp Med Biol. 2006;589:155-69 [17076280] Mol Cell Biol. 2006 Dec;26(23):8667-82 [17000779] Curr Biol. 2007 Mar 20;17(6):545-50 [17331723] Nat Genet. 2007 Sep;39(9):1100-7 [17660819] J Neurosci. 2007 Oct 24;27(43):11595-603 [17959802] Nucleic Acids Res. 2007;35(19):6526-38 [17897962] Am J Hum Genet. 2007 Dec;81(6):1169-85 [17999358] Development. 2008 Jan;135(2):237-47 [18057099] Dev Biol. 2008 Jan 15;313(2):568-83 [18068699] PLoS Genet. 2008 Feb;4(2):e1000003 [18454205] Nat Genet. 1993 Mar;3(3):241-6 [8387379] Genome Res. 2000 Jan;10(1):17-29 [10645946] Genes Dev. 2000 Jan 15;14(2):158-62 [10652270] Cell. 2000 Feb 18;100(4):423-34 [10693759] J Biol Chem. 2000 May 12;275(19):14013-6 [10747853] Bioessays. 2000 Aug;22(8):708-16 [10918301] Nat Genet. 2000 Aug;25(4):381-4 [10932178] Hum Mol Genet. 2000 Aug 12;9(13):1907-17 [10942418] Hum Genet. 2000 Jul;107(1):1-6 [10982026] J Biol Chem. 2000 Oct 6;275(40):30757-60 [10938265] J Biol Chem. 2000 Dec 1;275(48):37978-83 [10973953] Genes Dev. 2001 Jan 1;15(1):66-78 [11156606] Dev Biol. 2001 May 1;233(1):22-37 [11319855] Hum Genet. 2002 Jan;110(1):64-7 [11810298] Nat Rev Genet. 2002 Mar;3(3):176-88 [11972155] Hum Mol Genet. 2002 May 1;11(9):1129-35 [11978771] Hum Mol Genet. 2002 Dec 1;11(25):3231-6 [12444107] J Cell Biol. 2002 Dec 9;159(5):867-80 [12473692] Pigment Cell Res. 2003 Jun;16(3):261-5 [12753399] Oncogene. 2003 May 19;22(20):3024-34 [12789277] Dev Biol. 2003 Jul 1;259(1):19-33 [12812785] Pigment Cell Res. 2003 Oct;16(5):448-54 [12950719] Curr Opin Genet Dev. 2003 Oct;13(5):513-21 [14550418] Genes Dev. 2004 Apr 15;18(8):937-51 [15107405] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8 [15071178] J Embryol Exp Morphol. 1967 Jun;17(3):543-81 [6049666] Mol Cell Biol. 1990 Oct;10(10):5408-15 [2118997] Nature. 1991 Aug 8;352(6335):539-40 [1650914] Nature. 1992 Feb 13;355(6361):635-6 [1347148] Cell. 1994 Dec 30;79(7):1257-66 [8001158] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/hmg/ddn110 ER - TY - JOUR T1 - Physical Activity during Adulthood and Adolescence in Relation to Renal Cell Cancer AN - 20909375; 8422659 AB - Evidence for a relation between physical activity and renal cell cancer has been inconsistent. The authors examined physical activity in relation to renal cell cancer in a large, prospective US cohort study of 482,386 participants (289,503 men and 192,883 women) aged 50-71 years at baseline (1995-1996). At baseline, participants reported their frequency of exercise of at least 20 minutes' duration, intensity of daily routine activity, and frequency of physical activity during adolescence. During 8.2 years of follow-up (through December 2003), 1,238 cases of renal cell cancer were ascertained. In multivariate Cox regression models adjusted for renal cell cancer risk factors, the authors observed that current exercise, routine physical activity, and activity during adolescence were associated with a reduced risk of renal cell cancer. The multivariate relative risks for the highest activity level as compared with the lowest were 0.77 (95% confidence interval (CI): 0.64, 0.92; ptrend = 0.10) for current exercise, 0.84 (95% CI: 0.57, 1.22; ptrend = 0.03) for routine physical activity, and 0.82 (95% CI: 0.68, 1.00; ptrend = 0.05) for activity during adolescence. The authors conclude that increased physical activity, including activity during adolescence, is associated with reduced risk of renal cell cancer. JF - American Journal of Epidemiology AU - Moore, Steven C AU - Chow, Wong-Ho AU - Schatzkin, Arthur AU - Adams, Kenneth F AU - Park, Yikyung AU - Ballard-Barbash, Rachel AU - Hollenbeck, Albert AU - Leitzmann, Michael F AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, moorest@mail.nih.gov Y1 - 2008/07/15/ PY - 2008 DA - 2008 Jul 15 SP - 149 EP - 157 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 168 IS - 2 SN - 0002-9262, 0002-9262 KW - Physical Education Index KW - Epidemiology KW - Exercise (duration) KW - Exercise (intensity) KW - Risk factors KW - Adolescence KW - Women KW - Kidneys KW - Exercise KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20909375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Physical+Activity+during+Adulthood+and+Adolescence+in+Relation+to+Renal+Cell+Cancer&rft.au=Moore%2C+Steven+C%3BChow%2C+Wong-Ho%3BSchatzkin%2C+Arthur%3BAdams%2C+Kenneth+F%3BPark%2C+Yikyung%3BBallard-Barbash%2C+Rachel%3BHollenbeck%2C+Albert%3BLeitzmann%2C+Michael+F&rft.aulast=Moore&rft.aufirst=Steven&rft.date=2008-07-15&rft.volume=168&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwn102 LA - English DB - Physical Education Index N1 - Date revised - 2008-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Exercise; Kidneys; Cancer; Adolescence; Exercise (intensity); Women; Risk factors; Exercise (duration); Epidemiology DO - http://dx.doi.org/10.1093/aje/kwn102 ER - TY - JOUR T1 - A method of assessing the sensitivity of the Cochran-Mantel-Haenszel test to an unobserved confounder. AN - 70783265; 18407900 AB - Observational studies, including the case-control design frequently used in epidemiology, are subject to a number of biases and possible confounding factors. Failure to adjust with them may lead to an erroneous conclusion about the existence of a causal relationship between exposure and disease. The Cochran-Mantel-Haenszel (CMH) test is widely used to measure the strength of the association between an exposure and disease or response, after stratifying on the observed covariates. Thus, observed confounders are accounted for in the analysis. In practice, there may be causal variables that are unknown or difficult to obtain. Hence, they are not incorporated into the analysis. Sensitivity analysis enables investigators to assess the robustness of the findings. A method for assessing the sensitivity of the CMH test to an omitted confounder is presented here. The technique is illustrated by re-examining two datasets: one concerns the effect of maternal hypertension as a risk factor for low birth weight infants and the other focuses on the risk of allopurinol on having a rash. The computer code performing the sensitivity analysis is provided in appendix A. JF - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences AU - Yu, Binbing AU - Gastwirth, Joseph L AD - Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD 20892, USA. yubi@mail.nih.gov Y1 - 2008/07/13/ PY - 2008 DA - 2008 Jul 13 SP - 2377 EP - 2388 VL - 366 IS - 1874 SN - 1364-503X, 1364-503X KW - Allopurinol KW - 63CZ7GJN5I KW - Index Medicus KW - Sensitivity and Specificity KW - Drug Eruptions -- etiology KW - Infant, Low Birth Weight KW - Humans KW - Infant, Newborn KW - Models, Statistical KW - Allopurinol -- adverse effects KW - Pregnancy KW - Hypertension -- complications KW - Maternal-Fetal Exchange KW - Risk Factors KW - Databases, Factual KW - Pregnancy Complications, Cardiovascular KW - Female KW - Biometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70783265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+transactions.+Series+A%2C+Mathematical%2C+physical%2C+and+engineering+sciences&rft.atitle=A+method+of+assessing+the+sensitivity+of+the+Cochran-Mantel-Haenszel+test+to+an+unobserved+confounder.&rft.au=Yu%2C+Binbing%3BGastwirth%2C+Joseph+L&rft.aulast=Yu&rft.aufirst=Binbing&rft.date=2008-07-13&rft.volume=366&rft.issue=1874&rft.spage=2377&rft.isbn=&rft.btitle=&rft.title=Philosophical+transactions.+Series+A%2C+Mathematical%2C+physical%2C+and+engineering+sciences&rft.issn=1364503X&rft_id=info:doi/10.1098%2Frsta.2008.0030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: MMWR Morb Mortal Wkly Rep. 2002 Jul 12;51(27):589-92 [12139201] N Engl J Med. 1972 Mar 9;286(10):505-7 [4258181] Ethn Dis. 2007 Winter;17(1):40-8 [17274208] N Engl J Med. 1997 Oct 23;337(17):1209-14 [9337381] Biostatistics. 2005 Apr;6(2):201-9 [15772100] Biometrics. 1986 Dec;42(4):927-32 [3814733] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1098/rsta.2008.0030 ER - TY - CPAPER T1 - Respiratory Syncytial Virus Non-structural Proteins NS1 and NS2 Suppress Maturation of Dendritic Cells T2 - 27th Annual Meeting of the American Society for Virology AN - 41066338; 4913181 JF - 27th Annual Meeting of the American Society for Virology AU - Munir, Shirin AU - Luongo, Cindy AU - Nouen, Cyril Le AU - Buchholz, Ursula J AU - Collins, Peter L AU - Bukreyev, Alexander Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Dendritic cells KW - Respiration KW - Metabolism KW - Sexual maturity KW - Respiratory syncytial virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41066338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Respiratory+Syncytial+Virus+Non-structural+Proteins+NS1+and+NS2+Suppress+Maturation+of+Dendritic+Cells&rft.au=Munir%2C+Shirin%3BLuongo%2C+Cindy%3BNouen%2C+Cyril+Le%3BBuchholz%2C+Ursula+J%3BCollins%2C+Peter+L%3BBukreyev%2C+Alexander&rft.aulast=Munir&rft.aufirst=Shirin&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temperature-dependent Production of Pseudo-infectious Dengue Virions by Complementation T2 - 27th Annual Meeting of the American Society for Virology AN - 41066174; 4913080 JF - 27th Annual Meeting of the American Society for Virology AU - Ansarah-Sobrinho, Camilo AU - Nelson, Steevenson AU - Jost, Christiane A AU - Whitehead, Stephen S AU - Pierson, Theodore C Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Dengue KW - Virions KW - Temperature effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41066174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Temperature-dependent+Production+of+Pseudo-infectious+Dengue+Virions+by+Complementation&rft.au=Ansarah-Sobrinho%2C+Camilo%3BNelson%2C+Steevenson%3BJost%2C+Christiane+A%3BWhitehead%2C+Stephen+S%3BPierson%2C+Theodore+C&rft.aulast=Ansarah-Sobrinho&rft.aufirst=Camilo&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of Viable Polioviruses Encoding Insertions in Non-Structural Proteins T2 - 27th Annual Meeting of the American Society for Virology AN - 41065264; 4913773 JF - 27th Annual Meeting of the American Society for Virology AU - Jensen Jr, Kenneth AU - Levinson, Eric A AU - Ehrenfeld, Ellie AU - Teterina, Natalya L Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41065264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Isolation+of+Viable+Polioviruses+Encoding+Insertions+in+Non-Structural+Proteins&rft.au=Jensen+Jr%2C+Kenneth%3BLevinson%2C+Eric+A%3BEhrenfeld%2C+Ellie%3BTeterina%2C+Natalya+L&rft.aulast=Jensen+Jr&rft.aufirst=Kenneth&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Comparisons between Human and Avian Influenza a Virus PB2 Proteins T2 - 27th Annual Meeting of the American Society for Virology AN - 41065100; 4913549 JF - 27th Annual Meeting of the American Society for Virology AU - Graef, Katy M AU - Subbarao, Kanta AU - Fodor, Ervin Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Influenza KW - Fowl plague KW - Influenza A virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41065100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Functional+Comparisons+between+Human+and+Avian+Influenza+a+Virus+PB2+Proteins&rft.au=Graef%2C+Katy+M%3BSubbarao%2C+Kanta%3BFodor%2C+Ervin&rft.aulast=Graef&rft.aufirst=Katy&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccinia Virus L1 Virion Membrane Protein is Required for Entry but Not Virus Assembly T2 - 27th Annual Meeting of the American Society for Virology AN - 41064370; 4913124 JF - 27th Annual Meeting of the American Society for Virology AU - Bisht, Himani AU - Moss, Bernard Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Membrane proteins KW - Virions KW - Vaccinia virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41064370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Vaccinia+Virus+L1+Virion+Membrane+Protein+is+Required+for+Entry+but+Not+Virus+Assembly&rft.au=Bisht%2C+Himani%3BMoss%2C+Bernard&rft.aulast=Bisht&rft.aufirst=Himani&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Safety and Immunogenicity of Three Experimental cDNA-Derived Live-Attenuated Human Parainfluenzavirus Type 3 Vaccines in Adults and Children T2 - 27th Annual Meeting of the American Society for Virology AN - 41064318; 4913011 JF - 27th Annual Meeting of the American Society for Virology AU - Schmidt, Alexander AU - Casey, Roberta AU - Schappell, Elizabeth AU - Thumar, Bhavin AU - DiLorenzo, Susan AU - Collins, Peter AU - Murphy, Brian AU - Karron, Ruth Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Vaccines KW - Immunogenicity KW - Children KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41064318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Safety+and+Immunogenicity+of+Three+Experimental+cDNA-Derived+Live-Attenuated+Human+Parainfluenzavirus+Type+3+Vaccines+in+Adults+and+Children&rft.au=Schmidt%2C+Alexander%3BCasey%2C+Roberta%3BSchappell%2C+Elizabeth%3BThumar%2C+Bhavin%3BDiLorenzo%2C+Susan%3BCollins%2C+Peter%3BMurphy%2C+Brian%3BKarron%2C+Ruth&rft.aulast=Schmidt&rft.aufirst=Alexander&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Engineering Newcastle Disease Virus in Order to Enhance its Potential as a Human Vaccine Vector T2 - 27th Annual Meeting of the American Society for Virology AN - 41064261; 4913104 JF - 27th Annual Meeting of the American Society for Virology AU - DiNapoli, Joshua M AU - Munir, Shirin AU - Yang, Lijuan AU - Murphy, Brian AU - Collins, Peter L AU - Bukreyev, Alexander Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Australia, New South Wales, Newcastle KW - Vaccines KW - Newcastle disease KW - Disease transmission KW - Public health KW - Hosts KW - Disease control KW - Newcastle disease virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41064261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Engineering+Newcastle+Disease+Virus+in+Order+to+Enhance+its+Potential+as+a+Human+Vaccine+Vector&rft.au=DiNapoli%2C+Joshua+M%3BMunir%2C+Shirin%3BYang%2C+Lijuan%3BMurphy%2C+Brian%3BCollins%2C+Peter+L%3BBukreyev%2C+Alexander&rft.aulast=DiNapoli&rft.aufirst=Joshua&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Retrovirus Expression System Complements an Essential Rhesus Cytomegalovirus (RhCMV) Gene, Glycoprotein L, Required for RhCMV Infection T2 - 27th Annual Meeting of the American Society for Virology AN - 41064152; 4913065 JF - 27th Annual Meeting of the American Society for Virology AU - Lacayo, Juan C AU - Cohen, Jeffrey I Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Glycoproteins KW - Infection KW - Retrovirus KW - Cytomegalovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41064152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=A+Retrovirus+Expression+System+Complements+an+Essential+Rhesus+Cytomegalovirus+%28RhCMV%29+Gene%2C+Glycoprotein+L%2C+Required+for+RhCMV+Infection&rft.au=Lacayo%2C+Juan+C%3BCohen%2C+Jeffrey+I&rft.aulast=Lacayo&rft.aufirst=Juan&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Epidemiological and Evolutionary Dynamics of Human Rotavirus G1 VP7 Genes T2 - 27th Annual Meeting of the American Society for Virology AN - 41063667; 4913404 JF - 27th Annual Meeting of the American Society for Virology AU - Realpe, Mauricio AU - Santos, Norma AU - Hoshino, Yasutaka Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Evolution KW - Human rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41063667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=The+Epidemiological+and+Evolutionary+Dynamics+of+Human+Rotavirus+G1+VP7+Genes&rft.au=Realpe%2C+Mauricio%3BSantos%2C+Norma%3BHoshino%2C+Yasutaka&rft.aulast=Realpe&rft.aufirst=Mauricio&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Caspase Cleavage of KSHV ORF57 Protein is a Novel Cellular Defense Mechanism Against KSHV Lytic Infection T2 - 27th Annual Meeting of the American Society for Virology AN - 41063565; 4913099 JF - 27th Annual Meeting of the American Society for Virology AU - Majerciak, Vladimir AU - Zheng, Zhi-Ming Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Infection KW - Caspase KW - Defense mechanisms KW - Kaposi's sarcoma-associated herpesvirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41063565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Caspase+Cleavage+of+KSHV+ORF57+Protein+is+a+Novel+Cellular+Defense+Mechanism+Against+KSHV+Lytic+Infection&rft.au=Majerciak%2C+Vladimir%3BZheng%2C+Zhi-Ming&rft.aulast=Majerciak&rft.aufirst=Vladimir&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - G2-phase-dependent Cell Cycle Disturbances Caused by Human Parvovirus B19 in CD36+ Erythroid Progenitor Cells T2 - 27th Annual Meeting of the American Society for Virology AN - 41063354; 4913367 JF - 27th Annual Meeting of the American Society for Virology AU - Wan, Zhihong AU - Zhi, Ning AU - Wong, Susan AU - Keyvanfar, Keyvan AU - Billings, Eric AU - Kajigaya, Sachiko AU - Young, Neal S Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Cell cycle KW - Stem cells KW - Human parvovirus B19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41063354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=G2-phase-dependent+Cell+Cycle+Disturbances+Caused+by+Human+Parvovirus+B19+in+CD36%2B+Erythroid+Progenitor+Cells&rft.au=Wan%2C+Zhihong%3BZhi%2C+Ning%3BWong%2C+Susan%3BKeyvanfar%2C+Keyvan%3BBillings%2C+Eric%3BKajigaya%2C+Sachiko%3BYoung%2C+Neal+S&rft.aulast=Wan&rft.aufirst=Zhihong&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Parvovirus B19 Induces Apoptosis of CD36@@u+@ Erythroid Progenitor Cells by Activation of Caspases 1 and 3 T2 - 27th Annual Meeting of the American Society for Virology AN - 41063179; 4913535 JF - 27th Annual Meeting of the American Society for Virology AU - Wong, Susan AU - Zhi, Ning AU - Keyvanfar, Keyvan AU - Wan, Zhihong AU - Billings, Eric M AU - Kajigaya, Sachiko AU - Young, Neal S Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Apoptosis KW - Caspase-1 KW - Stem cells KW - Human parvovirus B19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41063179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Human+Parvovirus+B19+Induces+Apoptosis+of+CD36%40%40u%2B%40+Erythroid+Progenitor+Cells+by+Activation+of+Caspases+1+and+3&rft.au=Wong%2C+Susan%3BZhi%2C+Ning%3BKeyvanfar%2C+Keyvan%3BWan%2C+Zhihong%3BBillings%2C+Eric+M%3BKajigaya%2C+Sachiko%3BYoung%2C+Neal+S&rft.aulast=Wong&rft.aufirst=Susan&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deletion of the Nonstructural Proteins NS1 and NS2 of Pneumonia Virus of Mice (PVM) Attenuates Viral Replication and Prevents Disease Associated with a Strong Expression of Inflammatory and T Cell-Associated Cytokines T2 - 27th Annual Meeting of the American Society for Virology AN - 41063154; 4913370 JF - 27th Annual Meeting of the American Society for Virology AU - Buchholz, Ursula J AU - Ward, Jerrold M AU - Lamirande, Elaine W AU - Krempl, Christine D AU - Collins, Peter L Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mice KW - Replication KW - Cytokines KW - Pneumonia KW - Nonstructural proteins KW - Inflammation KW - Pneumonia virus of mice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41063154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Deletion+of+the+Nonstructural+Proteins+NS1+and+NS2+of+Pneumonia+Virus+of+Mice+%28PVM%29+Attenuates+Viral+Replication+and+Prevents+Disease+Associated+with+a+Strong+Expression+of+Inflammatory+and+T+Cell-Associated+Cytokines&rft.au=Buchholz%2C+Ursula+J%3BWard%2C+Jerrold+M%3BLamirande%2C+Elaine+W%3BKrempl%2C+Christine+D%3BCollins%2C+Peter+L&rft.aulast=Buchholz&rft.aufirst=Ursula&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Evolutionary Genetics and Emergency of Avian Influenza Viruses in Wild Birds T2 - 27th Annual Meeting of the American Society for Virology AN - 41063058; 4913480 JF - 27th Annual Meeting of the American Society for Virology AU - Dugan, Vivien G AU - Chen, Rubing AU - Spiro, David J AU - Wang, Ruixue AU - Slemons, Richard D AU - Holmes, Edward C AU - Taubenberger, Jeffery K Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Evolutionary genetics KW - Aves KW - Influenza KW - Viruses KW - Fowl plague KW - Emergencies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41063058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=The+Evolutionary+Genetics+and+Emergency+of+Avian+Influenza+Viruses+in+Wild+Birds&rft.au=Dugan%2C+Vivien+G%3BChen%2C+Rubing%3BSpiro%2C+David+J%3BWang%2C+Ruixue%3BSlemons%2C+Richard+D%3BHolmes%2C+Edward+C%3BTaubenberger%2C+Jeffery+K&rft.aulast=Dugan&rft.aufirst=Vivien&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maturation of West Nile Virus Modulates Sensitivity to Antibody-mediated Neutralization T2 - 27th Annual Meeting of the American Society for Virology AN - 41062909; 4913302 JF - 27th Annual Meeting of the American Society for Virology AU - Nelson, Steevenson AU - Jost, Christiane A AU - Martin, Julie E AU - Whitehead, Stephen S AU - Durbin, Anna P AU - Graham, Barney S AU - Diamond, Michael S AU - Pierson, Theodore C Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Neutralization KW - Sexual maturity KW - West Nile virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41062909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Maturation+of+West+Nile+Virus+Modulates+Sensitivity+to+Antibody-mediated+Neutralization&rft.au=Nelson%2C+Steevenson%3BJost%2C+Christiane+A%3BMartin%2C+Julie+E%3BWhitehead%2C+Stephen+S%3BDurbin%2C+Anna+P%3BGraham%2C+Barney+S%3BDiamond%2C+Michael+S%3BPierson%2C+Theodore+C&rft.aulast=Nelson&rft.aufirst=Steevenson&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conformational Changes in the HIV Envelope Glycoprotein Probed by Covalent Inhibitors T2 - 27th Annual Meeting of the American Society for Virology AN - 41062866; 4913432 JF - 27th Annual Meeting of the American Society for Virology AU - Jacobs, Amy AU - Quraishi, Omar AU - Huang, Xicai AU - Bousquet-Gagnon, Nathalie AU - Nault, Genevieve AU - Francella, Nicholas AU - Alvord, W Gregory AU - Pham, Nga AU - Soucy, Chantal AU - Robitaille, Martin AU - Bridon, Dominique AU - Blumenthal, Robert Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Glycoproteins KW - Human immunodeficiency virus KW - Envelopes KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41062866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Conformational+Changes+in+the+HIV+Envelope+Glycoprotein+Probed+by+Covalent+Inhibitors&rft.au=Jacobs%2C+Amy%3BQuraishi%2C+Omar%3BHuang%2C+Xicai%3BBousquet-Gagnon%2C+Nathalie%3BNault%2C+Genevieve%3BFrancella%2C+Nicholas%3BAlvord%2C+W+Gregory%3BPham%2C+Nga%3BSoucy%2C+Chantal%3BRobitaille%2C+Martin%3BBridon%2C+Dominique%3BBlumenthal%2C+Robert&rft.aulast=Jacobs&rft.aufirst=Amy&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Analysis of Human Parainfluenza Virus Type 3, Metapneumovirus and Respiratory Syncytial Virus Induced Maturation of Dendritic Cells and CD4 T Cell Proliferation T2 - 27th Annual Meeting of the American Society for Virology AN - 41062816; 4913413 JF - 27th Annual Meeting of the American Society for Virology AU - Le Nouen, Cyril AU - Hillyer, Philippa AU - Munir, Shirin AU - Losq, Stephanie AU - McCarty, Thomas AU - Winter, Christine AU - Burkreyev, Alexander AU - Stephany, David A AU - Holmes, Kevin L AU - Rabin, Ronald L AU - Collins, Peter L AU - Buchholz, Ursula J Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Cell proliferation KW - Dendritic cells KW - Lymphocytes T KW - CD4 antigen KW - Parainfluenza KW - Respiration KW - Metabolism KW - Sexual maturity KW - Respiratory syncytial virus KW - Parainfluenza virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41062816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Comparative+Analysis+of+Human+Parainfluenza+Virus+Type+3%2C+Metapneumovirus+and+Respiratory+Syncytial+Virus+Induced+Maturation+of+Dendritic+Cells+and+CD4+T+Cell+Proliferation&rft.au=Le+Nouen%2C+Cyril%3BHillyer%2C+Philippa%3BMunir%2C+Shirin%3BLosq%2C+Stephanie%3BMcCarty%2C+Thomas%3BWinter%2C+Christine%3BBurkreyev%2C+Alexander%3BStephany%2C+David+A%3BHolmes%2C+Kevin+L%3BRabin%2C+Ronald+L%3BCollins%2C+Peter+L%3BBuchholz%2C+Ursula+J&rft.aulast=Le+Nouen&rft.aufirst=Cyril&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunogenicity and Efficacy of H6 Avian Influenza Virus Vaccine Candidates in Mice T2 - 27th Annual Meeting of the American Society for Virology AN - 41062814; 4912973 JF - 27th Annual Meeting of the American Society for Virology AU - Santos, Celia P AU - Chen, Zhongying AU - Gillim-Ross, Laura AU - Aspelund, Amy AU - Yang, Chin-Fen AU - Jin, Hong AU - Kemble, George AU - Subbarao, Kanta Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Vaccines KW - Immunogenicity KW - Mice KW - Influenza KW - Fowl plague KW - Disease control KW - Avian influenza virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41062814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Immunogenicity+and+Efficacy+of+H6+Avian+Influenza+Virus+Vaccine+Candidates+in+Mice&rft.au=Santos%2C+Celia+P%3BChen%2C+Zhongying%3BGillim-Ross%2C+Laura%3BAspelund%2C+Amy%3BYang%2C+Chin-Fen%3BJin%2C+Hong%3BKemble%2C+George%3BSubbarao%2C+Kanta&rft.aulast=Santos&rft.aufirst=Celia&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insights into Rotavirus RdRP Activation by the Inner Capsid Protein VP2 T2 - 27th Annual Meeting of the American Society for Virology AN - 41062784; 4912962 JF - 27th Annual Meeting of the American Society for Virology AU - McDonald, Sarah M AU - Patton, John T Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Capsid protein KW - Rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41062784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Insights+into+Rotavirus+RdRP+Activation+by+the+Inner+Capsid+Protein+VP2&rft.au=McDonald%2C+Sarah+M%3BPatton%2C+John+T&rft.aulast=McDonald&rft.aufirst=Sarah&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence for a Novel RING Domain in Rotavirus NSP1 T2 - 27th Annual Meeting of the American Society for Virology AN - 41062350; 4912960 JF - 27th Annual Meeting of the American Society for Virology AU - Arnold, Michelle M AU - Patton, John T Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Replication KW - Rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41062350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Evidence+for+a+Novel+RING+Domain+in+Rotavirus+NSP1&rft.au=Arnold%2C+Michelle+M%3BPatton%2C+John+T&rft.aulast=Arnold&rft.aufirst=Michelle&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of Flavivirus Interferon Antagonist Proteins Reveals West Nile Virus (Strain NY99) NS5 as a Potent Suppressor of Interferon-mediated JAK-STAT Signaling T2 - 27th Annual Meeting of the American Society for Virology AN - 41062146; 4912896 JF - 27th Annual Meeting of the American Society for Virology AU - Best, Sonja M AU - Wolfinbarger, James B AU - Carmody, Aaron AU - Shupert, W Lesley AU - Holbrook, Michael R AU - Barrett, Alan AU - Mason, Peter W AU - Liu, Wenjun AU - Khromykh, Alexander AU - Bloom, Marshall E Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Signal transduction KW - Interferon KW - Suppressors KW - Strains KW - Flavivirus KW - West Nile virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41062146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=A+Comparison+of+Flavivirus+Interferon+Antagonist+Proteins+Reveals+West+Nile+Virus+%28Strain+NY99%29+NS5+as+a+Potent+Suppressor+of+Interferon-mediated+JAK-STAT+Signaling&rft.au=Best%2C+Sonja+M%3BWolfinbarger%2C+James+B%3BCarmody%2C+Aaron%3BShupert%2C+W+Lesley%3BHolbrook%2C+Michael+R%3BBarrett%2C+Alan%3BMason%2C+Peter+W%3BLiu%2C+Wenjun%3BKhromykh%2C+Alexander%3BBloom%2C+Marshall+E&rft.aulast=Best&rft.aufirst=Sonja&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Whole Genome Sequence and Phylogenetic Analyses Reveal that Human Rotavirus G3P[3] Strains Ro1845 and HCR3A are of Feline or Canine Origin T2 - 27th Annual Meeting of the American Society for Virology AN - 41061284; 4912964 JF - 27th Annual Meeting of the American Society for Virology AU - Tsugawa, Takeshi AU - Hoshino, Yasutaka Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Genomes KW - Phylogenetics KW - Nucleotide sequence KW - Strains KW - Human rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41061284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Whole+Genome+Sequence+and+Phylogenetic+Analyses+Reveal+that+Human+Rotavirus+G3P%5B3%5D+Strains+Ro1845+and+HCR3A+are+of+Feline+or+Canine+Origin&rft.au=Tsugawa%2C+Takeshi%3BHoshino%2C+Yasutaka&rft.aulast=Tsugawa&rft.aufirst=Takeshi&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Dendritic Cell Maturation and TLR Responses by a Tick-borne Flavivirus T2 - 27th Annual Meeting of the American Society for Virology AN - 41061040; 4913045 JF - 27th Annual Meeting of the American Society for Virology AU - Robertson, Shelly J AU - Mitzel, Dana N AU - Messer, Ronald J AU - Best, Sonja M AU - Bloom, Marshall E Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Dendritic cells KW - Sexual maturity KW - Flavivirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41061040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Inhibition+of+Dendritic+Cell+Maturation+and+TLR+Responses+by+a+Tick-borne+Flavivirus&rft.au=Robertson%2C+Shelly+J%3BMitzel%2C+Dana+N%3BMesser%2C+Ronald+J%3BBest%2C+Sonja+M%3BBloom%2C+Marshall+E&rft.aulast=Robertson&rft.aufirst=Shelly&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Development of Recombinant Caliciviruses for Study of Viral Replication T2 - 27th Annual Meeting of the American Society for Virology AN - 41060610; 4913643 JF - 27th Annual Meeting of the American Society for Virology AU - Abente, Eugenio J AU - Sosnovtsev, Stanislav V AU - Bok, Karin AU - Levenson, Eric AU - Teterina, Natalya L AU - Ehrenfeld, Ellie AU - Green, Kim Y Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Replication KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41060610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=The+Development+of+Recombinant+Caliciviruses+for+Study+of+Viral+Replication&rft.au=Abente%2C+Eugenio+J%3BSosnovtsev%2C+Stanislav+V%3BBok%2C+Karin%3BLevenson%2C+Eric%3BTeterina%2C+Natalya+L%3BEhrenfeld%2C+Ellie%3BGreen%2C+Kim+Y&rft.aulast=Abente&rft.aufirst=Eugenio&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Replication Defective Herpes Simplex Virus 2 (HSV-2) dl5-29 Effectively Prevents Acute and Recurrent Genital Herpes in HSV-1 Seropositive Guinea Pigs T2 - 27th Annual Meeting of the American Society for Virology AN - 41060179; 4913591 JF - 27th Annual Meeting of the American Society for Virology AU - Hoshino, Yo AU - Pesnicak, Lesley AU - Dowdell, Kennichi C AU - Knipe, David M AU - Straus, Stephen E AU - Cohen, Jeffrey I Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Replication KW - Herpes simplex KW - Herpes simplex virus 2 KW - Herpes simplex virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41060179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Replication+Defective+Herpes+Simplex+Virus+2+%28HSV-2%29+dl5-29+Effectively+Prevents+Acute+and+Recurrent+Genital+Herpes+in+HSV-1+Seropositive+Guinea+Pigs&rft.au=Hoshino%2C+Yo%3BPesnicak%2C+Lesley%3BDowdell%2C+Kennichi+C%3BKnipe%2C+David+M%3BStraus%2C+Stephen+E%3BCohen%2C+Jeffrey+I&rft.aulast=Hoshino&rft.aufirst=Yo&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A General Approach for Inactivating Enveloped Viruses with Preservation of Structural Integrity for Vaccine Applications T2 - 27th Annual Meeting of the American Society for Virology AN - 41060080; 4913590 JF - 27th Annual Meeting of the American Society for Virology AU - Viard, Mathias AU - Blumenthal, Robert AU - Hogan, Robert J AU - Tompkins, Stephen M AU - Warfield, Kelly L AU - Bavari, Sina AU - Aman, Javad AU - Sharma, Anuj AU - Maheshwari, Radha K AU - Raviv, Yossef Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Vaccines KW - Viruses KW - Preservation KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41060080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=A+General+Approach+for+Inactivating+Enveloped+Viruses+with+Preservation+of+Structural+Integrity+for+Vaccine+Applications&rft.au=Viard%2C+Mathias%3BBlumenthal%2C+Robert%3BHogan%2C+Robert+J%3BTompkins%2C+Stephen+M%3BWarfield%2C+Kelly+L%3BBavari%2C+Sina%3BAman%2C+Javad%3BSharma%2C+Anuj%3BMaheshwari%2C+Radha+K%3BRaviv%2C+Yossef&rft.aulast=Viard&rft.aufirst=Mathias&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polioviruses Expressing Fluorescent-tagged 2A Proteins T2 - 27th Annual Meeting of the American Society for Virology AN - 41059832; 4913170 JF - 27th Annual Meeting of the American Society for Virology AU - Teterina, Natalya L AU - Jensen, Kenneth AU - Levenson, Eric A AU - Ehrenfeld, Ellie Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41059832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Polioviruses+Expressing+Fluorescent-tagged+2A+Proteins&rft.au=Teterina%2C+Natalya+L%3BJensen%2C+Kenneth%3BLevenson%2C+Eric+A%3BEhrenfeld%2C+Ellie&rft.aulast=Teterina&rft.aufirst=Natalya&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The VP7 of Two G9 Rotaviruses Isolated in 1980 from Diarrheal Stool Samples Collected in Washington, DC, is Unique Molecularly and Serotypically T2 - 27th Annual Meeting of the American Society for Virology AN - 41059751; 4913117 JF - 27th Annual Meeting of the American Society for Virology AU - Cao, Dianjun AU - Santos, Norma AU - Jones, Ronald W AU - Tatsumi, Masatoshi AU - Gentsch, Jon R AU - Hoshino, Yasutaka Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Feces KW - Diarrhea UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41059751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=The+VP7+of+Two+G9+Rotaviruses+Isolated+in+1980+from+Diarrheal+Stool+Samples+Collected+in+Washington%2C+DC%2C+is+Unique+Molecularly+and+Serotypically&rft.au=Cao%2C+Dianjun%3BSantos%2C+Norma%3BJones%2C+Ronald+W%3BTatsumi%2C+Masatoshi%3BGentsch%2C+Jon+R%3BHoshino%2C+Yasutaka&rft.aulast=Cao&rft.aufirst=Dianjun&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tubacin, a Histone Deacetylase 6 Inhibitor, Kills Epstein-Barr Virus (EBV)-Positive Burkitt Lymphoma Cell Lines by Induction of Reactive Oxygen Species and EBV Lymphoblastoid Cells Lines by Induction of Caspases T2 - 27th Annual Meeting of the American Society for Virology AN - 41059534; 4913066 JF - 27th Annual Meeting of the American Society for Virology AU - Kawada, Junichi AU - Zou, Ping AU - Mazitschek, Ralph AU - Bradner, James E AU - Cohen, Jeffrey I Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Lymphoma KW - Reactive oxygen species KW - Caspase KW - Tumor cell lines KW - Histone deacetylase KW - Lymphoblastoid cell lines KW - Burkitt's lymphoma KW - Histones KW - Inhibitors KW - Epstein-Barr virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41059534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Tubacin%2C+a+Histone+Deacetylase+6+Inhibitor%2C+Kills+Epstein-Barr+Virus+%28EBV%29-Positive+Burkitt+Lymphoma+Cell+Lines+by+Induction+of+Reactive+Oxygen+Species+and+EBV+Lymphoblastoid+Cells+Lines+by+Induction+of+Caspases&rft.au=Kawada%2C+Junichi%3BZou%2C+Ping%3BMazitschek%2C+Ralph%3BBradner%2C+James+E%3BCohen%2C+Jeffrey+I&rft.aulast=Kawada&rft.aufirst=Junichi&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The DNA-binding Transcription Factor NF-1A Negatively Regulates JC Virus Multiplication T2 - 27th Annual Meeting of the American Society for Virology AN - 41059268; 4913025 JF - 27th Annual Meeting of the American Society for Virology AU - Major, Eugene O AU - Ravichandran, Veerasamy Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Transcription factors KW - JC virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41059268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=The+DNA-binding+Transcription+Factor+NF-1A+Negatively+Regulates+JC+Virus+Multiplication&rft.au=Major%2C+Eugene+O%3BRavichandran%2C+Veerasamy&rft.aulast=Major&rft.aufirst=Eugene&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respiratory Syncytial Virus Secreted G Protein Helps the Virus Evade Antibody Neutralization T2 - 27th Annual Meeting of the American Society for Virology AN - 41059192; 4913410 JF - 27th Annual Meeting of the American Society for Virology AU - Bukreyev, Alexander AU - Yang, Lijuan AU - Fricke, Jens AU - Murphy, Brian R AU - Collins, Peter L Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Neutralization KW - Antibodies KW - Respiration KW - Metabolism KW - Respiratory syncytial virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41059192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Respiratory+Syncytial+Virus+Secreted+G+Protein+Helps+the+Virus+Evade+Antibody+Neutralization&rft.au=Bukreyev%2C+Alexander%3BYang%2C+Lijuan%3BFricke%2C+Jens%3BMurphy%2C+Brian+R%3BCollins%2C+Peter+L&rft.aulast=Bukreyev&rft.aufirst=Alexander&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toward Identification of Effective Inhibitors for Human Polyomavirus Multiplication T2 - 27th Annual Meeting of the American Society for Virology AN - 41059110; 4913489 JF - 27th Annual Meeting of the American Society for Virology AU - Ravichandran, Veerasamy AU - Major, Eugene O Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Inhibitors KW - Polyomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41059110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Toward+Identification+of+Effective+Inhibitors+for+Human+Polyomavirus+Multiplication&rft.au=Ravichandran%2C+Veerasamy%3BMajor%2C+Eugene+O&rft.aulast=Ravichandran&rft.aufirst=Veerasamy&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The C Proteins of Human Parainfluenza Virus Type 1 (HPIV1) Control a Broad Array of Cellular Genes, Orchestrating a Stealth Attack T2 - 27th Annual Meeting of the American Society for Virology AN - 41058920; 4913435 JF - 27th Annual Meeting of the American Society for Virology AU - Boonyaratanakornkit, Jim B AU - Bartlett, Emmalene J AU - Amaro-Carambot, Emerito AU - Collins, Peter L AU - Murphy, Brian R AU - Schmidt, Alexander C Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - C protein KW - Parainfluenza KW - Parainfluenza virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41058920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=The+C+Proteins+of+Human+Parainfluenza+Virus+Type+1+%28HPIV1%29+Control+a+Broad+Array+of+Cellular+Genes%2C+Orchestrating+a+Stealth+Attack&rft.au=Boonyaratanakornkit%2C+Jim+B%3BBartlett%2C+Emmalene+J%3BAmaro-Carambot%2C+Emerito%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BSchmidt%2C+Alexander+C&rft.aulast=Boonyaratanakornkit&rft.aufirst=Jim&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction of Amino Acid Substitutions within E and NS5 Proteins Attenuate Chimeric TBE/ DEN Virus Neurovirulence for Suckling Mice T2 - 27th Annual Meeting of the American Society for Virology AN - 41058844; 4913300 JF - 27th Annual Meeting of the American Society for Virology AU - Engel, Amber R AU - Murphy, Brian R AU - Pletnev, Alexander G Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Amino acids KW - Mice KW - Suckling behavior KW - NS5 protein KW - Amino acid substitution KW - Neurovirulence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41058844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Introduction+of+Amino+Acid+Substitutions+within+E+and+NS5+Proteins+Attenuate+Chimeric+TBE%2F+DEN+Virus+Neurovirulence+for+Suckling+Mice&rft.au=Engel%2C+Amber+R%3BMurphy%2C+Brian+R%3BPletnev%2C+Alexander+G&rft.aulast=Engel&rft.aufirst=Amber&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Membrane Traffic Protein GBF1 Contributes to Poliovirus RNA Replication T2 - 27th Annual Meeting of the American Society for Virology AN - 41058614; 4913354 JF - 27th Annual Meeting of the American Society for Virology AU - Belov, George A AU - Feng, Qian AU - Nicovics, Krisztina AU - Jackson, Catherine L AU - Ehrenfeld, Ellie Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Poliovirus KW - Membrane proteins KW - Traffic KW - Replication KW - RNA KW - Membrane trafficking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41058614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Cellular+Membrane+Traffic+Protein+GBF1+Contributes+to+Poliovirus+RNA+Replication&rft.au=Belov%2C+George+A%3BFeng%2C+Qian%3BNicovics%2C+Krisztina%3BJackson%2C+Catherine+L%3BEhrenfeld%2C+Ellie&rft.aulast=Belov&rft.aufirst=George&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Neural Progenitor-Derived Oligodendrocytes and JCV Infection T2 - 27th Annual Meeting of the American Society for Virology AN - 41058492; 4913543 JF - 27th Annual Meeting of the American Society for Virology AU - Monaco, Maria Chiara G AU - Maric, Dragan AU - Major, Eugene O Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Infection KW - Oligodendrocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41058492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Human+Neural+Progenitor-Derived+Oligodendrocytes+and+JCV+Infection&rft.au=Monaco%2C+Maria+Chiara+G%3BMaric%2C+Dragan%3BMajor%2C+Eugene+O&rft.aulast=Monaco&rft.aufirst=Maria+Chiara&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SEN Virus Infection in Egyptian Patients on Maintenance Hemodialysis: Prevalence and Clinical Importance T2 - 27th Annual Meeting of the American Society for Virology AN - 41058332; 4912946 JF - 27th Annual Meeting of the American Society for Virology AU - Loutfy, Samah A AU - Hafez, Mohamed M AU - Massoud, Waleed A AU - Fotuh, Nemat M. Aboul Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Infection KW - Hemodialysis KW - SEN virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41058332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=SEN+Virus+Infection+in+Egyptian+Patients+on+Maintenance+Hemodialysis%3A+Prevalence+and+Clinical+Importance&rft.au=Loutfy%2C+Samah+A%3BHafez%2C+Mohamed+M%3BMassoud%2C+Waleed+A%3BFotuh%2C+Nemat+M.+Aboul&rft.aulast=Loutfy&rft.aufirst=Samah&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure/ function Studies of Poliovirus Protein 2C T2 - 27th Annual Meeting of the American Society for Virology AN - 41057833; 4912903 JF - 27th Annual Meeting of the American Society for Virology AU - Adams, Peter L AU - Ehrenfeld, Ellie Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Poliovirus KW - Structure-function relationships KW - Protein 2C UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41057833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Structure%2F+function+Studies+of+Poliovirus+Protein+2C&rft.au=Adams%2C+Peter+L%3BEhrenfeld%2C+Ellie&rft.aulast=Adams&rft.aufirst=Peter&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elucidation of the Molecular Basis for the Attenuation of a Live, Attenuated Influenza a H5N1 Cold-adapted Vaccine Virus T2 - 27th Annual Meeting of the American Society for Virology AN - 41057150; 4912974 JF - 27th Annual Meeting of the American Society for Virology AU - Amorsolo Jr., L. Suguitan AU - Marino, Michael P AU - Desai, Purvi D AU - Chen, Li-Mei AU - Matsuoka, Yumiko AU - Donis, Ruben O AU - Jin, Hong AU - Swayne, David E AU - Kemble, George AU - Subbarao, Kanta Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Vaccines KW - Influenza KW - Influenza A KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41057150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Elucidation+of+the+Molecular+Basis+for+the+Attenuation+of+a+Live%2C+Attenuated+Influenza+a+H5N1+Cold-adapted+Vaccine+Virus&rft.au=Amorsolo+Jr.%2C+L.+Suguitan%3BMarino%2C+Michael+P%3BDesai%2C+Purvi+D%3BChen%2C+Li-Mei%3BMatsuoka%2C+Yumiko%3BDonis%2C+Ruben+O%3BJin%2C+Hong%3BSwayne%2C+David+E%3BKemble%2C+George%3BSubbarao%2C+Kanta&rft.aulast=Amorsolo+Jr.&rft.aufirst=L.&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of an SA11 Rotavirus Variant Expressing a Mutant NSP3 T2 - 27th Annual Meeting of the American Society for Virology AN - 41057125; 4912959 JF - 27th Annual Meeting of the American Society for Virology AU - Taraporewala, Zenobia F AU - Brownback, Catie AU - Barro, Mario AU - Patton, John T Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mutants KW - Rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41057125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Characterization+of+an+SA11+Rotavirus+Variant+Expressing+a+Mutant+NSP3&rft.au=Taraporewala%2C+Zenobia+F%3BBrownback%2C+Catie%3BBarro%2C+Mario%3BPatton%2C+John+T&rft.aulast=Taraporewala&rft.aufirst=Zenobia&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Separation of the Overlapping P and V Open Reading Frames of Parainfluenza Virus Type 2 into Distinct Gene Units T2 - 27th Annual Meeting of the American Society for Virology AN - 41054530; 4913059 JF - 27th Annual Meeting of the American Society for Virology AU - Schaap-Nutt, Anne AU - Nolan, Sheila M AU - Amaro-Carambot, Emerito AU - Davis, Stephanie AU - Bradley, Konrad AU - Wise, Shenelle-Marie AU - Skiadopoulos, Mario H AU - Collins, Peter L AU - Murphy, Brian R AU - Schmidt, Alexander C Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Open reading frames KW - Parainfluenza KW - Parainfluenza virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41054530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Separation+of+the+Overlapping+P+and+V+Open+Reading+Frames+of+Parainfluenza+Virus+Type+2+into+Distinct+Gene+Units&rft.au=Schaap-Nutt%2C+Anne%3BNolan%2C+Sheila+M%3BAmaro-Carambot%2C+Emerito%3BDavis%2C+Stephanie%3BBradley%2C+Konrad%3BWise%2C+Shenelle-Marie%3BSkiadopoulos%2C+Mario+H%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BSchmidt%2C+Alexander+C&rft.aulast=Schaap-Nutt&rft.aufirst=Anne&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Parainfluenza Virus Type 1 (HPIV1) C Proteins Inhibit Interferon and Apoptotic Responses in Host Cells and are Required for Efficient Replication T2 - 27th Annual Meeting of the American Society for Virology AN - 41054030; 4913408 JF - 27th Annual Meeting of the American Society for Virology AU - Bartlett, Emmalene J AU - Cruz, Ann-Marie AU - Esker, Janice AU - Castano, Adam AU - Collins, Peter L AU - Murphy, Brian R AU - Schmidt, Alexander C Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Replication KW - Interferon KW - Apoptosis KW - C protein KW - Parainfluenza KW - Parainfluenza virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41054030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Human+Parainfluenza+Virus+Type+1+%28HPIV1%29+C+Proteins+Inhibit+Interferon+and+Apoptotic+Responses+in+Host+Cells+and+are+Required+for+Efficient+Replication&rft.au=Bartlett%2C+Emmalene+J%3BCruz%2C+Ann-Marie%3BEsker%2C+Janice%3BCastano%2C+Adam%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BSchmidt%2C+Alexander+C&rft.aulast=Bartlett&rft.aufirst=Emmalene&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Virus Variation Resources at NCBI: New Databases and Analysis Tools for Searching, Retrieving, and Exploring Dengue, West Nile, and Hepatitis C Virus Sequences T2 - 27th Annual Meeting of the American Society for Virology AN - 41053140; 4913308 JF - 27th Annual Meeting of the American Society for Virology AU - Resch, Wolfgang AU - Bao, Yiming AU - Bolotov, Pavel AU - Rozanov, Michael AU - Zaslavsky, Leonid AU - Tatusova, Tatiana Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Hepatitis KW - Dengue KW - Databases KW - Hepatitis C virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41053140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.atitle=Virus+Variation+Resources+at+NCBI%3A+New+Databases+and+Analysis+Tools+for+Searching%2C+Retrieving%2C+and+Exploring+Dengue%2C+West+Nile%2C+and+Hepatitis+C+Virus+Sequences&rft.au=Resch%2C+Wolfgang%3BBao%2C+Yiming%3BBolotov%2C+Pavel%3BRozanov%2C+Michael%3BZaslavsky%2C+Leonid%3BTatusova%2C+Tatiana&rft.aulast=Resch&rft.aufirst=Wolfgang&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+Society+for+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2008/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rhythmic Motor Discharges Generated by Perfused Mouse Spinal Cord In Situ T2 - 6th FENS Forum of European Neuroscience AN - 41033438; 4897672 JF - 6th FENS Forum of European Neuroscience AU - Yazawa, I AU - ODonovan, M Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Spinal cord KW - Rhythms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41033438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Rhythmic+Motor+Discharges+Generated+by+Perfused+Mouse+Spinal+Cord+In+Situ&rft.au=Yazawa%2C+I%3BODonovan%2C+M&rft.aulast=Yazawa&rft.aufirst=I&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular, Pharmacological and Functional Properties of GABA-A Receptors in Anterior Pituitary Cells T2 - 6th FENS Forum of European Neuroscience AN - 41032536; 4898925 JF - 6th FENS Forum of European Neuroscience AU - Zemkova, H W AU - Tomic, M AU - Bjelobaba, I AU - Zemkova, H AU - Stojilkovic, S S Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - G-Aminobutyric acid A receptors KW - Pituitary (anterior) KW - Pituitary gland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41032536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Molecular%2C+Pharmacological+and+Functional+Properties+of+GABA-A+Receptors+in+Anterior+Pituitary+Cells&rft.au=Zemkova%2C+H+W%3BTomic%2C+M%3BBjelobaba%2C+I%3BZemkova%2C+H%3BStojilkovic%2C+S+S&rft.aulast=Zemkova&rft.aufirst=H&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Specific Role for Frontal Pole Cortex in Encoding Rewards: Reward-As-Feedback Not Reward-As-Cue T2 - 6th FENS Forum of European Neuroscience AN - 41031246; 4900703 JF - 6th FENS Forum of European Neuroscience AU - Tsujimoto, S AU - Genovesio, A AU - Wise, S P Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Reinforcement KW - Cortex KW - Cortex (frontal) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41031246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=A+Specific+Role+for+Frontal+Pole+Cortex+in+Encoding+Rewards%3A+Reward-As-Feedback+Not+Reward-As-Cue&rft.au=Tsujimoto%2C+S%3BGenovesio%2C+A%3BWise%2C+S+P&rft.aulast=Tsujimoto&rft.aufirst=S&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Short-Term Plasticity at Developing Thalamocortical Inputs Mediated by Molecularly and Functionally Distinct Presynaptic Kainate Receptors T2 - 6th FENS Forum of European Neuroscience AN - 41030121; 4897944 JF - 6th FENS Forum of European Neuroscience AU - Jouhanneau, J S AU - Ball, S AU - Nas, u-Nishimura Y AU - Roche, K AU - Mulle, C AU - Molnar, E AU - Isaac, J T R Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Glutamic acid receptors KW - Kainic acid receptors KW - Cortex KW - Thalamus KW - Plasticity (presynaptic) KW - Plasticity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41030121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Short-Term+Plasticity+at+Developing+Thalamocortical+Inputs+Mediated+by+Molecularly+and+Functionally+Distinct+Presynaptic+Kainate+Receptors&rft.au=Jouhanneau%2C+J+S%3BBall%2C+S%3BNas%2C+u-Nishimura+Y%3BRoche%2C+K%3BMulle%2C+C%3BMolnar%2C+E%3BIsaac%2C+J+T+R&rft.aulast=Jouhanneau&rft.aufirst=J&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amygdala and Orbitofrontal Cortex Lesions Differentially Influence Choices during Object Reversal Learning T2 - 6th FENS Forum of European Neuroscience AN - 41026812; 4899730 JF - 6th FENS Forum of European Neuroscience AU - Murray, E A AU - Rudebeck, P H Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Lesions KW - Amygdala KW - Cortex KW - Reversal learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41026812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Amygdala+and+Orbitofrontal+Cortex+Lesions+Differentially+Influence+Choices+during+Object+Reversal+Learning&rft.au=Murray%2C+E+A%3BRudebeck%2C+P+H&rft.aulast=Murray&rft.aufirst=E&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cholecystokinin and Parvalbumin-Positive CA1 Basket Cells Undergo Differential Cholinergic Neuromodulation: A Blurring of Rhythm and Mood T2 - 6th FENS Forum of European Neuroscience AN - 41025669; 4897889 JF - 6th FENS Forum of European Neuroscience AU - Lawrence, J J AU - Del Rio, C.Cea AU - Tricoire, L AU - Erdelyi, F AU - Szabo, G AU - McBain, C J Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Cholecystokinin KW - Neuromodulation KW - Mood KW - Rhythms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41025669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Cholecystokinin+and+Parvalbumin-Positive+CA1+Basket+Cells+Undergo+Differential+Cholinergic+Neuromodulation%3A+A+Blurring+of+Rhythm+and+Mood&rft.au=Lawrence%2C+J+J%3BDel+Rio%2C+C.Cea%3BTricoire%2C+L%3BErdelyi%2C+F%3BSzabo%2C+G%3BMcBain%2C+C+J&rft.aulast=Lawrence&rft.aufirst=J&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Transporters Shape Glutamatergic Signaling and Plasticity at Hippocampal Synapses T2 - 6th FENS Forum of European Neuroscience AN - 41023656; 4897968 JF - 6th FENS Forum of European Neuroscience AU - Scimemi, A AU - Diamond, J S Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Signal transduction KW - Plasticity (hippocampal) KW - Synapses KW - Hippocampus KW - Glutamatergic transmission KW - Plasticity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41023656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Neuronal+Transporters+Shape+Glutamatergic+Signaling+and+Plasticity+at+Hippocampal+Synapses&rft.au=Scimemi%2C+A%3BDiamond%2C+J+S&rft.aulast=Scimemi&rft.aufirst=A&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions of SERT & BDNF: A Complex Genetic Model of Human Depression T2 - 6th FENS Forum of European Neuroscience AN - 41023549; 4897090 JF - 6th FENS Forum of European Neuroscience AU - Pezawas, L AU - Meyer-Lindenberg, A AU - Goldman, A L AU - Verchinski, B A AU - Chen, G AU - Kolachana, B S AU - Egan, E F AU - Mattay, V S AU - Hariri, A R AU - Weinberger, D R Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Depression KW - Serotonin transporter KW - Brain-derived neurotrophic factor KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41023549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Interactions+of+SERT+%26amp%3B+BDNF%3A+A+Complex+Genetic+Model+of+Human+Depression&rft.au=Pezawas%2C+L%3BMeyer-Lindenberg%2C+A%3BGoldman%2C+A+L%3BVerchinski%2C+B+A%3BChen%2C+G%3BKolachana%2C+B+S%3BEgan%2C+E+F%3BMattay%2C+V+S%3BHariri%2C+A+R%3BWeinberger%2C+D+R&rft.aulast=Pezawas&rft.aufirst=L&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nigrostriatal Synchrony after Dopamine Blockade in Freely-Moving Rodents T2 - 6th FENS Forum of European Neuroscience AN - 41023218; 4900540 JF - 6th FENS Forum of European Neuroscience AU - Burkhardt, J M AU - Costa, R M Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Rodents KW - Dopamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41023218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Nigrostriatal+Synchrony+after+Dopamine+Blockade+in+Freely-Moving+Rodents&rft.au=Burkhardt%2C+J+M%3BCosta%2C+R+M&rft.aulast=Burkhardt&rft.aufirst=J&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trafficking and Phosphorylation of NR2C-Containing NMDA Receptors T2 - 6th FENS Forum of European Neuroscience AN - 41023010; 4897139 JF - 6th FENS Forum of European Neuroscience AU - Roche, K Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Phosphorylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41023010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Trafficking+and+Phosphorylation+of+NR2C-Containing+NMDA+Receptors&rft.au=Roche%2C+K&rft.aulast=Roche&rft.aufirst=K&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microvascular Factor VIII Staining Pattern Correlates with the Duration of Infarct after Ischemic Stroke and Thrombolysis in Rats T2 - 6th FENS Forum of European Neuroscience AN - 41022884; 4899085 JF - 6th FENS Forum of European Neuroscience AU - Schatlo, B AU - Henning, E C AU - Latour, L L AU - Merrill, M AU - Oldfield, E H AU - Pluta, R M Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Stroke KW - Rats KW - Ischemia KW - Microvasculature KW - Thrombolysis KW - Coagulation factors KW - Staining UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41022884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Microvascular+Factor+VIII+Staining+Pattern+Correlates+with+the+Duration+of+Infarct+after+Ischemic+Stroke+and+Thrombolysis+in+Rats&rft.au=Schatlo%2C+B%3BHenning%2C+E+C%3BLatour%2C+L+L%3BMerrill%2C+M%3BOldfield%2C+E+H%3BPluta%2C+R+M&rft.aulast=Schatlo&rft.aufirst=B&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Docking Mechanism Controlling Axonal Mitochondrial Motility and its Impact on Synaptic Plasticity T2 - 6th FENS Forum of European Neuroscience AN - 41022827; 4897092 JF - 6th FENS Forum of European Neuroscience AU - Sheng, Z H AU - Kang, J S AU - Pan, P Y AU - Tian, J H Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Motility KW - Mitochondria KW - Plasticity (synaptic) KW - Plasticity KW - Berthing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41022827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=A+Docking+Mechanism+Controlling+Axonal+Mitochondrial+Motility+and+its+Impact+on+Synaptic+Plasticity&rft.au=Sheng%2C+Z+H%3BKang%2C+J+S%3BPan%2C+P+Y%3BTian%2C+J+H&rft.aulast=Sheng&rft.aufirst=Z&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impaired Stress-Coping and Fear Extinction and Abnormal Corticolimbic Morphology in Serotonin Transporter Knock-Out Mice T2 - 6th FENS Forum of European Neuroscience AN - 41022046; 4897089 JF - 6th FENS Forum of European Neuroscience AU - Holmes, A Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Extinction KW - Mice KW - Morphology KW - Serotonin transporter KW - Fear conditioning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41022046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Impaired+Stress-Coping+and+Fear+Extinction+and+Abnormal+Corticolimbic+Morphology+in+Serotonin+Transporter+Knock-Out+Mice&rft.au=Holmes%2C+A&rft.aulast=Holmes&rft.aufirst=A&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping the Synaptic Connectivity that Underlies Cortical Circuit Development Using Single Cell Photostimulation T2 - 6th FENS Forum of European Neuroscience AN - 41020863; 4900445 JF - 6th FENS Forum of European Neuroscience AU - Ashby, M C AU - Isaac, J T Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mapping KW - Circuits KW - Cortex KW - Neural networks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41020863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Mapping+the+Synaptic+Connectivity+that+Underlies+Cortical+Circuit+Development+Using+Single+Cell+Photostimulation&rft.au=Ashby%2C+M+C%3BIsaac%2C+J+T&rft.aulast=Ashby&rft.aufirst=M&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Dorsal Striatum Lesions in Instrumental Learning in Mice T2 - 6th FENS Forum of European Neuroscience AN - 41020684; 4898272 JF - 6th FENS Forum of European Neuroscience AU - Hilario, M AU - Holloway, T AU - Costa, R Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Mice KW - Lesions KW - Learning KW - Neostriatum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41020684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Effects+of+Dorsal+Striatum+Lesions+in+Instrumental+Learning+in+Mice&rft.au=Hilario%2C+M%3BHolloway%2C+T%3BCosta%2C+R&rft.aulast=Hilario&rft.aufirst=M&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ipsilateral Cortical fMRI Responses Following Peripheral Nerve Damage in Rats Reflect Interneuron-Mediated Inhibition T2 - 6th FENS Forum of European Neuroscience AN - 41020348; 4899680 JF - 6th FENS Forum of European Neuroscience AU - Pelled, G AU - Conroy, R S AU - Bergstrom, D A AU - Tucciarone, J M AU - Walters, J R AU - Koretsky, A P Y1 - 2008/07/12/ PY - 2008 DA - 2008 Jul 12 KW - Rats KW - Peripheral nerves KW - Functional magnetic resonance imaging KW - Cortex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41020348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+FENS+Forum+of+European+Neuroscience&rft.atitle=Ipsilateral+Cortical+fMRI+Responses+Following+Peripheral+Nerve+Damage+in+Rats+Reflect+Interneuron-Mediated+Inhibition&rft.au=Pelled%2C+G%3BConroy%2C+R+S%3BBergstrom%2C+D+A%3BTucciarone%2C+J+M%3BWalters%2C+J+R%3BKoretsky%2C+A+P&rft.aulast=Pelled&rft.aufirst=G&rft.date=2008-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+FENS+Forum+of+European+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://fens2008.neurosciences.asso.fr/pages/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. AN - 69296813; 18487201 AB - After protracted low level arsenic exposure, the normal human prostate epithelial cell line RWPE-1 acquires a malignant phenotype with DNA hypomethylation, indicative of disrupted methyl metabolism, and shows arsenic adaptation involving glutathione overproduction and enhanced arsenic efflux. Thus, the interplay between methyl and glutathione metabolism during this progressive arsenic adaptation was studied. Arsenic-treated cells showed a time-dependent increase in LC50 and a marked increase in homocysteine (Hcy) levels. A marked suppression of S-adenosylmethionine (SAM) levels occurred with decreased methionine adenosyltransferase 2A (converts methionine to SAM) expression and increased negative regulator methionine adenosyltransferase B, suggesting reduced conversion of Hcy to SAM. Consistent with Hcy overproduction, activity and expression of S-adenosylhomocysteine hydrolase (converts S-adenosylhomocysteine to Hcy) were both increased. Expression of cystathionine beta-synthase, a key gene in the transsulfuration pathway, and various glutathione production genes were increased, resulting in a 5-fold increase in glutathione. Arsenic efflux increased along with expression of ATP-binding cassette protein C1, which effluxes arsenic as a glutathione conjugate. Evidence of genomic DNA hypomethylation was observed during early arsenic exposure, indicating that the disruption in methyl metabolism had a potential impact related to oncogenesis. Thus, cellular arsenic adaptation is a dynamic, progressive process that involves decreased SAM recycling and concurrent accumulation of Hcy, which is channeled via transsulfuration to increase glutathione and enhance arsenic efflux but may also impact the carcinogenic process. JF - The Journal of biological chemistry AU - Coppin, Jean-François AU - Qu, Wei AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/07/11/ PY - 2008 DA - 2008 Jul 11 SP - 19342 EP - 19350 VL - 283 IS - 28 SN - 0021-9258, 0021-9258 KW - Arsenites KW - 0 KW - Enzyme Inhibitors KW - Multidrug Resistance-Associated Proteins KW - Sodium Compounds KW - Homocysteine KW - 0LVT1QZ0BA KW - sodium arsenite KW - 48OVY2OC72 KW - S-Adenosylmethionine KW - 7LP2MPO46S KW - MAT2A protein, human KW - EC 2.5.1.6 KW - Methionine Adenosyltransferase KW - Adenosylhomocysteinase KW - EC 3.3.1.1 KW - Cystathionine beta-Synthase KW - EC 4.2.1.22 KW - Glutathione KW - GAN16C9B8O KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Homocysteine -- metabolism KW - Adenosylhomocysteinase -- biosynthesis KW - Multidrug Resistance-Associated Proteins -- biosynthesis KW - Humans KW - Glutathione -- metabolism KW - DNA Methylation -- drug effects KW - S-Adenosylmethionine -- metabolism KW - Methionine Adenosyltransferase -- biosynthesis KW - Male KW - Cystathionine beta-Synthase -- biosynthesis KW - Cell Line KW - Sodium Compounds -- pharmacology KW - Arsenites -- pharmacology KW - Epithelial Cells -- enzymology KW - Cell Transformation, Neoplastic -- pathology KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Epithelial Cells -- pathology KW - Cell Transformation, Neoplastic -- metabolism KW - Prostate -- enzymology KW - Enzyme Inhibitors -- pharmacology KW - Prostate -- pathology KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69296813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Interplay+between+cellular+methyl+metabolism+and+adaptive+efflux+during+oncogenic+transformation+from+chronic+arsenic+exposure+in+human+cells.&rft.au=Coppin%2C+Jean-Fran%C3%A7ois%3BQu%2C+Wei%3BWaalkes%2C+Michael+P&rft.aulast=Coppin&rft.aufirst=Jean-Fran%C3%A7ois&rft.date=2008-07-11&rft.volume=283&rft.issue=28&rft.spage=19342&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M802942200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-28 N1 - Date created - 2008-07-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Top Microbiol Immunol. 2006;310:251-74 [16909914] Birth Defects Res A Clin Mol Teratol. 2006 Apr;76(4):230-6 [16575882] Biochem Biophys Res Commun. 2007 Jan 5;352(1):188-92 [17107663] Toxicology. 2007 Jul 1;236(1-2):7-15 [17451858] Eur Urol. 2007 Aug;52(2):470-7 [17267100] DNA Cell Biol. 2007 Aug;26(8):603-11 [17688412] Environ Health Perspect. 2008 Feb;116(2):158-64 [18288312] Int J Biochem Cell Biol. 2000 Apr;32(4):391-5 [10762064] Toxicol Sci. 2000 Apr;54(2):500-8 [10774833] J Theor Biol. 2000 Jun 21;204(4):521-32 [10833353] Chem Res Toxicol. 2001 Apr;14(4):355-61 [11304123] Mol Pharmacol. 2001 Aug;60(2):302-9 [11455017] Toxicol Appl Pharmacol. 2001 Oct 15;176(2):127-44 [11601889] Carcinogenesis. 2002 May;23(5):777-85 [12016150] J Nutr. 2002 Aug;132(8 Suppl):2361S-2366S [12163693] Toxicol Appl Pharmacol. 2002 Sep 1;183(2):99-107 [12387749] J Natl Cancer Inst. 2002 Dec 18;94(24):1888-91 [12488483] Leukemia. 2003 May;17(5):931-40 [12750708] Clin Chim Acta. 2003 Jul 1;333(1):19-39 [12809732] Biomed Pharmacother. 2003 May-Jun;57(3-4):145-55 [12818476] Mutat Res. 2003 Jul 25;528(1-2):61-74 [12873724] Environ Mol Mutagen. 2003;42(3):192-205 [14556226] J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 [15026472] Acta Biochim Pol. 2004;51(2):405-13 [15218538] J Biol Chem. 2004 Jul 30;279(31):32700-8 [15161912] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] Environ Health Perspect. 2004 Aug;112(12):1255-63 [15345372] Nucleic Acids Res. 1975 Oct;2(10):1639-51 [1208211] Pharmacol Rev. 1982 Sep;34(3):223-53 [6760211] J Pharm Pharmacol. 1984 Feb;36(2):85-9 [6143811] Arch Biochem Biophys. 1985 Aug 1;240(2):621-6 [4026297] Nucleic Acids Res. 1990 Dec 25;18(24):7213-8 [2259619] Cancer Res. 1992 Apr 1;52(7 Suppl):2071s-2077s [1544143] Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10065-9 [1359533] Cancer Res. 1996 Mar 1;56(5):995-1005 [8640792] Kidney Blood Press Res. 1996;19(2):100-8 [8871889] Cancer Res. 1997 Feb 15;57(4):594-9 [9044832] Carcinogenesis. 1997 Jun;18(6):1215-23 [9214605] Carcinogenesis. 1997 Jun;18(6):1225-31 [9214606] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] Cancer Lett. 1997 Dec 9;120(2):149-56 [9461031] J Biol Chem. 1999 Mar 19;274(12):7816-24 [10075673] Am J Clin Nutr. 2004 Nov;80(5):1312-21 [15531681] J Clin Oncol. 2004 Nov 15;22(22):4632-42 [15542813] Prog Mol Subcell Biol. 2005;38:151-67 [15881894] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Biochem Soc Trans. 2006 Apr;34(Pt 2):330-3 [16545107] Toxicol Sci. 2006 May;91(1):70-81 [16436460] Coll Antropol. 2006 Sep;30(3):665-71 [17058541] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M802942200 ER - TY - JOUR T1 - IRF4 addiction in multiple myeloma. AN - 69312997; 18568025 AB - The transcription factor IRF4 (interferon regulatory factor 4) is required during an immune response for lymphocyte activation and the generation of immunoglobulin-secreting plasma cells. Multiple myeloma, a malignancy of plasma cells, has a complex molecular aetiology with several subgroups defined by gene expression profiling and recurrent chromosomal translocations. Moreover, the malignant clone can sustain multiple oncogenic lesions, accumulating genetic damage as the disease progresses. Current therapies for myeloma can extend survival but are not curative. Hence, new therapeutic strategies are needed that target molecular pathways shared by all subtypes of myeloma. Here we show, using a loss-of-function, RNA-interference-based genetic screen, that IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism. Gene expression profiling and genome-wide chromatin immunoprecipitation analysis uncovered an extensive network of IRF4 target genes and identified MYC as a direct target of IRF4 in activated B cells and myeloma. Unexpectedly, IRF4 was itself a direct target of MYC transactivation, generating an autoregulatory circuit in myeloma cells. Although IRF4 is not genetically altered in most myelomas, they are nonetheless addicted to an aberrant IRF4 regulatory network that fuses the gene expression programmes of normal plasma cells and activated B cells. JF - Nature AU - Shaffer, Arthur L AU - Emre, N C Tolga AU - Lamy, Laurence AU - Ngo, Vu N AU - Wright, George AU - Xiao, Wenming AU - Powell, John AU - Dave, Sandeep AU - Yu, Xin AU - Zhao, Hong AU - Zeng, Yuxin AU - Chen, Bangzheng AU - Epstein, Joshua AU - Staudt, Louis M AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/07/10/ PY - 2008 DA - 2008 Jul 10 SP - 226 EP - 231 VL - 454 IS - 7201 KW - Interferon Regulatory Factors KW - 0 KW - Proto-Oncogene Proteins c-myc KW - interferon regulatory factor-4 KW - Index Medicus KW - Animals KW - B-Lymphocytes -- pathology KW - Humans KW - Mice KW - Proto-Oncogene Proteins c-myc -- metabolism KW - B-Lymphocytes -- metabolism KW - Transcriptional Activation KW - Cell Survival KW - Gene Expression Regulation, Neoplastic KW - Gene Expression Profiling KW - Cells, Cultured KW - Chromatin Immunoprecipitation KW - RNA Interference KW - Genes, myc -- genetics KW - Cell Transformation, Neoplastic -- genetics KW - Multiple Myeloma -- genetics KW - Interferon Regulatory Factors -- deficiency KW - Interferon Regulatory Factors -- genetics KW - Multiple Myeloma -- pathology KW - Multiple Myeloma -- metabolism KW - Interferon Regulatory Factors -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69312997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=IRF4+addiction+in+multiple+myeloma.&rft.au=Shaffer%2C+Arthur+L%3BEmre%2C+N+C+Tolga%3BLamy%2C+Laurence%3BNgo%2C+Vu+N%3BWright%2C+George%3BXiao%2C+Wenming%3BPowell%2C+John%3BDave%2C+Sandeep%3BYu%2C+Xin%3BZhao%2C+Hong%3BZeng%2C+Yuxin%3BChen%2C+Bangzheng%3BEpstein%2C+Joshua%3BStaudt%2C+Louis+M&rft.aulast=Shaffer&rft.aufirst=Arthur&rft.date=2008-07-10&rft.volume=454&rft.issue=7201&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=1476-4687&rft_id=info:doi/10.1038%2Fnature07064 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-07-10 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE8958; GEO; GSE9067; GSE9367 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):228-33 [10618400] Nature. 2000 Feb 3;403(6769):503-11 [10676951] J Exp Med. 2001 Dec 17;194(12):1861-74 [11748286] Nat Rev Cancer. 2002 Mar;2(3):175-87 [11990854] Blood. 2004 Jan 1;103(1):20-32 [12969978] Science. 2004 Feb 6;303(5659):844-8 [14704432] Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6062-7 [15075390] Cell. 1994 Aug 12;78(3):513-23 [8062391] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13931-6 [8943038] Science. 1997 Jan 24;275(5299):540-3 [8999800] Cancer Cell. 2004 Nov;6(5):439-44 [15542427] Nat Med. 2004 Dec;10(12):1329-35 [15531890] J Immunol. 2005 Mar 1;174(5):2573-81 [15728463] PLoS Biol. 2005 Mar;3(3):e69 [15737063] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [16199517] Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3645-50 [16537449] Cancer Cell. 2006 Apr;9(4):313-25 [16616336] Curr Top Microbiol Immunol. 2006;302:1-32 [16620023] Nature. 2006 May 4;441(7089):106-10 [16572121] Nat Immunol. 2006 Jul;7(7):773-82 [16767092] Nat Rev Cancer. 2006 Aug;6(8):593-602 [16862190] Immunity. 2006 Aug;25(2):225-36 [16919487] Blood. 2006 Sep 15;108(6):2020-8 [16728703] Semin Cancer Biol. 2006 Aug;16(4):253-64 [16904903] Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17834-9 [17093053] Leukemia. 2007 Mar;21(3):541-9 [17252022] Cell. 2007 Sep 21;130(6):986-8 [17889643] Mol Cell Biol. 2007 Nov;27(21):7381-93 [17785433] J Natl Cancer Inst Monogr. 2008;(39):25-31 [18647998] Comment In: Nature. 2008 Jul 10;454(7201):172-3 [18615074] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nature07064 ER - TY - JOUR T1 - Hydrolytic reactivity trends among potential prodrugs of the O2-glycosylated diazeniumdiolate family. Targeting nitric oxide to macrophages for antileishmanial activity. AN - 69296542; 18533711 AB - Glycosylated diazeniumdiolates of structure R 2NN(O)NO-R' (R' = a saccharide residue) are potential prodrugs of the nitric oxide (NO)-releasing but acid-sensitive R 2NN(O)NO (-) ion. Moreover, cleaving the acid-stable glycosides under alkaline conditions provides a convenient protecting group strategy for diazeniumdiolate ions. Here, we report comparative hydrolysis rate data for five representative glycosylated diazeniumdiolates at pH 14, 7.4, and 3.8-4.6 as background for further developing both the protecting group application and the ability to target NO pharmacologically to macrophages harboring intracellular pathogens. Confirming the potential in the latter application, adding R 2NN(O)NO-GlcNAc (where R 2N = diethylamino or pyrrolidin-l-yl and GlcNAc = N-acetylglucosamin-l-yl) to cultures of infected mouse macrophages that were deficient in inducible NO synthase caused rapid death of the intracellular protozoan parasite Leishmania major with no host cell toxicity. JF - Journal of medicinal chemistry AU - Valdez, Carlos A AU - Saavedra, Joseph E AU - Showalter, Brett M AU - Davies, Keith M AU - Wilde, Thomas C AU - Citro, Michael L AU - Barchi, Joseph J AU - Deschamps, Jeffrey R AU - Parrish, Damon AU - El-Gayar, Stefan AU - Schleicher, Ulrike AU - Bogdan, Christian AU - Keefer, Larry K AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2008/07/10/ PY - 2008 DA - 2008 Jul 10 SP - 3961 EP - 3970 VL - 51 IS - 13 KW - Antiprotozoal Agents KW - 0 KW - Azo Compounds KW - Carbohydrates KW - Prodrugs KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Molecular Structure KW - Animals KW - Antiprotozoal Agents -- pharmacology KW - Antiprotozoal Agents -- chemical synthesis KW - Models, Molecular KW - Hydrogen-Ion Concentration KW - Humans KW - Carbohydrates -- chemistry KW - Mice KW - Crystallography, X-Ray KW - Glycosylation KW - Antiprotozoal Agents -- chemistry KW - Leishmania major KW - Hydrolysis KW - Azo Compounds -- chemical synthesis KW - Prodrugs -- chemistry KW - Azo Compounds -- chemistry KW - Prodrugs -- pharmacology KW - Oxygen -- chemistry KW - Azo Compounds -- pharmacology KW - Nitric Oxide -- biosynthesis KW - Macrophages -- drug effects KW - Prodrugs -- chemical synthesis KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69296542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Hydrolytic+reactivity+trends+among+potential+prodrugs+of+the+O2-glycosylated+diazeniumdiolate+family.+Targeting+nitric+oxide+to+macrophages+for+antileishmanial+activity.&rft.au=Valdez%2C+Carlos+A%3BSaavedra%2C+Joseph+E%3BShowalter%2C+Brett+M%3BDavies%2C+Keith+M%3BWilde%2C+Thomas+C%3BCitro%2C+Michael+L%3BBarchi%2C+Joseph+J%3BDeschamps%2C+Jeffrey+R%3BParrish%2C+Damon%3BEl-Gayar%2C+Stefan%3BSchleicher%2C+Ulrike%3BBogdan%2C+Christian%3BKeefer%2C+Larry+K&rft.aulast=Valdez&rft.aufirst=Carlos&rft.date=2008-07-10&rft.volume=51&rft.issue=13&rft.spage=3961&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm8000482 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-12 N1 - Date created - 2008-07-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods Enzymol. 1996;268:281-93 [8782594] Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10688-92 [7479866] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] Immunity. 1998 Jan;8(1):77-87 [9462513] Exp Lung Res. 2005 Jan-Feb;31(1):57-82 [15765919] J Am Chem Soc. 2005 Oct 19;127(41):14188-9 [16218605] J Immunol. 2001 Mar 1;166(5):3075-82 [11207258] J Org Chem. 2001 May 4;66(9):3090-8 [11325274] Microbes Infect. 2002 Jan;4(1):23-9 [11825771] Immunobiology. 2001 Dec;204(5):527-35 [11846215] Crit Rev Oncol Hematol. 2002 Nov;44(2):143-61 [12413632] Infect Immun. 2002 Dec;70(12):6828-38 [12438359] Cell Res. 2002 Dec;12(5-6):311-20 [12528889] Eur J Immunol. 2003 May;33(5):1224-34 [12731047] J Immunol Methods. 1983 Dec 16;65(1-2):55-63 [6606682] Immunology. 1987 Nov;62(3):485-92 [3499384] J Immunol. 1990 Jan 1;144(1):278-83 [2104889] J Immunol. 1990 Dec 15;145(12):4290-7 [2124240] J Immunol. 1990 Dec 15;145(12):4306-10 [2175327] Eur J Immunol. 1991 Jul;21(7):1669-75 [1905642] J Biol Chem. 1992 Nov 15;267(32):23301-8 [1429677] J Biol Chem. 1993 Jan 5;268(1):399-404 [8416946] J Exp Med. 1993 Aug 1;178(2):605-13 [7688028] Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10984-9 [8855295] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm8000482 ER - TY - JOUR T1 - Activation of the Escherichia coli marA/soxS/rob Regulon in Response to Transcriptional Activator Concentration AN - 20920572; 8374732 AB - The paralogous transcriptional activators MarA, SoxS, and Rob activate a common set of promoters, the marA/soxS/rob regulon of Escherichia coli, by binding a cognate site (marbox) upstream of each promoter. The extent of activation varies from one promoter to another and is only poorly correlated with the in vitro affinity of the activator for the specific marbox. Here, we examine the dependence of promoter activation on the level of activator in vivo by manipulating the steady-state concentrations of MarA and SoxS in Lon protease mutants and by measuring promoter activation using lacZ transcriptional fusions. We found that: (i) the MarA concentrations needed for half-maximal stimulation varied by at least 19-fold among the 10 promoters tested; (ii) most marboxes were not saturated when there were 24,000 molecules of MarA per cell; (iii) the correlation between the MarA concentration needed for half-maximal promoter activity in vivo and marbox binding affinity in vitro was poor; and (iv) the two activators differed in their promoter activation profiles. The marRAB and sodA promoters could both be saturated by MarA and SoxS in vivo. However, saturation by MarA resulted in greater marRAB and lesser sodA transcription than did saturation by SoxS, implying that the two activators interact with RNA polymerase in different ways at the different promoters. Thus, the concentration and nature of activator determine which regulon promoters are activated, as well as the extent of their activation. JF - Journal of Molecular Biology AU - Martin, R G AU - Bartlett, E S AU - Rosner, J L AU - Wall, ME AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0560, USA, rgmartin@helix.nih.gov Y1 - 2008/07/04/ PY - 2008 DA - 2008 Jul 04 SP - 278 EP - 284 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 380 IS - 2 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Promoters KW - DNA-directed RNA polymerase KW - SoxS protein KW - Lon protein KW - Transcription factors KW - Escherichia coli KW - Transcription KW - Transcription activation KW - J 02410:Animal Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20920572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Activation+of+the+Escherichia+coli+marA%2FsoxS%2Frob+Regulon+in+Response+to+Transcriptional+Activator+Concentration&rft.au=Martin%2C+R+G%3BBartlett%2C+E+S%3BRosner%2C+J+L%3BWall%2C+ME&rft.aulast=Martin&rft.aufirst=R&rft.date=2008-07-04&rft.volume=380&rft.issue=2&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2008.05.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Promoters; DNA-directed RNA polymerase; SoxS protein; Lon protein; Transcription factors; Transcription; Transcription activation; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2008.05.015 ER - TY - JOUR T1 - Impact of Phosphorylation on Structure and Thermodynamics of the Interaction between the N-terminal Domain of Enzyme I and the Histidine Phosphocarrier Protein of the Bacterial Phosphotransferase System AN - 20052102; 8340002 AB - The structural and thermodynamic impact of phosphorylation on the interaction of the N-terminal domain of enzyme I (EIN) and the histidine phosphocarrier protein (HPr), the two common components of all branches of the bacterial phosphotransferase system, have been examined using NMR spectroscopy and isothermal titration calorimetry. His-189 is located at the interface of the alpha and alpha beta domains of EIN, resulting in rather widespread chemical shift perturbation upon phosphorylation, in contrast to the highly localized perturbations seen for HPr, where His-15 is fully exposed to solvent. Residual dipolar coupling measurements, however, demonstrate unambiguously that no significant changes in backbone conformation of either protein occur upon phosphorylation: for EIN, the relative orientation of the alpha and alpha beta domains remains unchanged; for HPr, the backbone {phi}/ psi torsion angles of the active site residues are unperturbed within experimental error. His arrow right Glu/Asp mutations of the active site histidines designed to mimic the phosphorylated states reveal binding equilibria that favor phosphoryl transfer from EIN to HPr. Although binding of phospho-EIN to phospho-HPr is reduced by a factor of similar to 21 relative to the unphosphorylated complex, residual dipolar coupling measurements reveal that the structures of the unphosphorylated and biphosphorylated complexes are the same. Hence, the phosphorylation states of EIN and HPr shift the binding equilibria predominantly by modulating intermolecular electrostatic interactions without altering either the backbone scaffold or binding interface. This facilitates highly efficient phosphoryl transfer between EIN and HPr, which is estimated to occur at a rate of similar to 850 s super(-1) from exchange spectroscopy. JF - Journal of Biological Chemistry AU - Suh, Jeong-Yong AU - Cai, Mengli AU - Clore, GMarius AD - Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/07/04/ PY - 2008 DA - 2008 Jul 04 SP - 18980 EP - 18989 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 27 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts KW - Bacteria KW - Thermodynamics KW - Solvents KW - Enzyme I KW - Electrostatic properties KW - phosphotransferase KW - Spectroscopy KW - scaffolds KW - Protein structure KW - Antibodies KW - Phosphorylation KW - phosphocarrier protein KW - Magnetic resonance spectroscopy KW - Histidine KW - Titration KW - Calorimetry KW - Mutation KW - J 02410:Animal Diseases KW - G 07770:Bacteria KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20052102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Impact+of+Phosphorylation+on+Structure+and+Thermodynamics+of+the+Interaction+between+the+N-terminal+Domain+of+Enzyme+I+and+the+Histidine+Phosphocarrier+Protein+of+the+Bacterial+Phosphotransferase+System&rft.au=Suh%2C+Jeong-Yong%3BCai%2C+Mengli%3BClore%2C+GMarius&rft.aulast=Suh&rft.aufirst=Jeong-Yong&rft.date=2008-07-04&rft.volume=283&rft.issue=27&rft.spage=18980&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Thermodynamics; Enzyme I; Solvents; Electrostatic properties; phosphotransferase; Spectroscopy; scaffolds; Protein structure; Antibodies; Phosphorylation; phosphocarrier protein; Histidine; Magnetic resonance spectroscopy; Titration; Calorimetry; Mutation; Bacteria ER - TY - JOUR T1 - Improved Procedure for Direct Coupling of Carbohydrates to Proteins via Reductive Amination AN - 754877196; 13301452 AB - Carbohydrate-protein conjugates are utilized extensively in basic research and as immunogens in a variety of bacterial vaccines and cancer vaccines. As a result, there have been significant efforts to develop simple and reliable methods for the construction of these conjugates. While direct coupling via reductive amination is an appealing approach, the reaction is typically very inefficient. In this paper, we report improved reaction conditions providing an approximately 500% increase in yield. In addition to optimizing a series of standard reaction parameters, we found that addition of 500 mM sodium sulfate improves the coupling efficiency. To illustrate the utility of these conditions, a series of high mannose BSA conjugates were produced and incorporated into a carbohydrate microarray. Ligand binding to ConA could be observed and apparent affinity constants (Kds) measured using the array were in good agreement with values reported by surface plasmon resonance. The results show that the conditions are suitable for microgram-scale reactions, are compatible with complex carbohydrates, and produce biologically active conjugates. JF - Bioconjugate Chemistry AU - Gildersleeve, Jeffrey C AU - Oyelaran, Oyindasola AU - Simpson, John T AU - Allred, Benjamin AD - Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, NIH, 376 Boyles Street, Building 376, Room 109, Frederick, Maryland 21702, and Protein Chemistry Laboratory, Advanced Technology Program, SAIC Frederick, Inc., NCI Frederick, Frederick, Maryland 21702 Y1 - 2008/07/03/ PY - 2008 DA - 2008 Jul 03 SP - 1485 EP - 1490 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA VL - 19 IS - 7 SN - 1043-1802, 1043-1802 KW - Microbiology Abstracts B: Bacteriology KW - Cancer vaccines KW - surface plasmon resonance KW - Concanavalin A KW - Mannose KW - Carbohydrates KW - sodium sulfate KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754877196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Improved+Procedure+for+Direct+Coupling+of+Carbohydrates+to+Proteins+via+Reductive+Amination&rft.au=Gildersleeve%2C+Jeffrey+C%3BOyelaran%2C+Oyindasola%3BSimpson%2C+John+T%3BAllred%2C+Benjamin&rft.aulast=Gildersleeve&rft.aufirst=Jeffrey&rft.date=2008-07-03&rft.volume=19&rft.issue=7&rft.spage=1485&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc800153t LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Cancer vaccines; Concanavalin A; surface plasmon resonance; Mannose; Carbohydrates; sodium sulfate DO - http://dx.doi.org/10.1021/bc800153t ER - TY - JOUR T1 - Monitoring of people and workers exposure to the electric, magnetic and electromagnetic fields in an Italian National Cancer Institute. AN - 69337396; 18598357 AB - The paper reports the electric, magnetic and electromagnetic fields (emf) measurements carried out in the Regina Elena National Cancer Institute (NCI). Several devices, used in diagnostics and in medical cures, can represent sources of emf for the workers and for the public subjected to the treatments. The aim is to evaluate their exposition, in order to assess the compliance with the law. The investigations have been carried out in the departments of: intensive care, physiotherapy, MR presstherapy and in the surgical rooms. The measurements have been performed using broad band probes in the frequency ranges 5 Hz/30 kHz and 100 kHz-3 GHz. The variability of the magnetic induction (B(microT)) levels is between 0,05 microT and 80 microT. The statistical distribution shows that most of the measurements are in the range 0,0530 days after initial hospital contact for a chronic disease, but it was also increased in children with .5 hospital contacts for any other reason. Children with a history of cancer, chronic renal disease, splenectomy, and transplantation were particularly susceptible to invasive pneumococcal disease. Adjusted for number of hospital contacts, the risk for children with other types of chronic disease was 1.4-fold more than for those with hospital contacts for any reason. CONCLUSIONS. Cancer, chronic renal diseases, splenectomy, and transplantation were strongly associated with an increased risk of invasive pneumococcal disease in children. For children with other chronic diseases, their excess risk seemed to be attributable mostly to frail children having repeated hospital contact rather than their underlying condition. JF - Pediatrics AU - Hjuler, Thomas AU - Wohlfahrt, Jan AU - Staum Kaltoft, Margit AU - Koch, Anders AU - Biggar, Robert John AU - Melbye, Mads AD - Departments of Epidemiology Research. Bacteriology, Mycology, and Parasitology, Statens Serum Institut, Copenhagen, Denmark. Viral Epidemiology Branch, Division of Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - e26 EP - e32 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 122 IS - 1 SN - 0031-4005, 0031-4005 KW - Risk Abstracts; Microbiology Abstracts B: Bacteriology KW - Historical account KW - Invasiveness KW - Splenectomy KW - Kidney transplantation KW - Kidney diseases KW - Children KW - Cancer KW - Streptococcus pneumoniae KW - Denmark KW - Hospitals KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20730275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Risks+of+Invasive+Pneumococcal+Disease+in+Children+With+Underlying+Chronic+Diseases&rft.au=Hjuler%2C+Thomas%3BWohlfahrt%2C+Jan%3BStaum+Kaltoft%2C+Margit%3BKoch%2C+Anders%3BBiggar%2C+Robert+John%3BMelbye%2C+Mads&rft.aulast=Hjuler&rft.aufirst=Thomas&rft.date=2008-07-01&rft.volume=122&rft.issue=1&rft.spage=e26&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Invasiveness; Splenectomy; Kidney transplantation; Kidney diseases; Children; Cancer; Hospitals; Historical account; Streptococcus pneumoniae; Denmark ER - TY - JOUR T1 - Protein and lysate array technologies in cancer research AN - 20725148; 8299228 AB - Capturing quantitative proteomic information provides new insights for enhancing the understanding of cancer biology. There have been several protein microarray formats, and each has an advantage depending on what is being detected. However, in contrast to nucleotide printing, the production of protein arrays generally requires the capability of handling viscous solutions, and the mishandling of various factors, such as temperature and humidity, adversely affect protein status. The requirement for such specifications is critical when increasing the throughput for monitoring a large number of samples for rigorous quantitation. In particular, a new solid pin arrayer has been extremely powerful when highly viscous cell lysates printed for high-density, ''reverse-phase'' protein arrays, and acquired data allows for theoretical models of protein signaling networks to be constructed. In this review, applications of currently available protein microarray technology to cancer research are discussed including the advantages of the new solid pin architecture for opening up powerful proteomic applications. JF - Biotechnology Advances AU - Spurrier, B AU - Honkanen, P AU - Holway, A AU - Kumamoto, K AU - Terashima, M AU - Takenoshita, S AU - Wakabayashi, G AU - Austin, J AU - Nishizuka, S AD - Molecular Therapeutics Program, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA, snishizu@iwate-med.ac.jp Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 361 EP - 369 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 26 IS - 4 SN - 0734-9750, 0734-9750 KW - Biotechnology and Bioengineering Abstracts KW - Printing KW - Reviews KW - Protein arrays KW - Temperature requirements KW - Humidity KW - proteomics KW - Protein status KW - Quantitation KW - Cancer KW - Nucleotides KW - Signal transduction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20725148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+Advances&rft.atitle=Protein+and+lysate+array+technologies+in+cancer+research&rft.au=Spurrier%2C+B%3BHonkanen%2C+P%3BHolway%2C+A%3BKumamoto%2C+K%3BTerashima%2C+M%3BTakenoshita%2C+S%3BWakabayashi%2C+G%3BAustin%2C+J%3BNishizuka%2C+S&rft.aulast=Spurrier&rft.aufirst=B&rft.date=2008-07-01&rft.volume=26&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Biotechnology+Advances&rft.issn=07349750&rft_id=info:doi/10.1016%2Fj.biotechadv.2008.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Printing; Reviews; Protein arrays; Temperature requirements; Humidity; Protein status; proteomics; Quantitation; Nucleotides; Cancer; Signal transduction DO - http://dx.doi.org/10.1016/j.biotechadv.2008.04.002 ER - TY - JOUR T1 - Radionuclide Imaging: A Molecular Key to the Atherosclerotic Plaque AN - 20264732; 8867382 AB - Despite primary and secondary prevention, serious cardiovascular events such as unstable angina or myocardial infarction still account for one-third of all deaths worldwide. Therefore, identifying individual patients with vulnerable plaques at high risk for plaque rupture is a central challenge in cardiovascular medicine. Several noninvasive techniques, such as magnetic resonance imaging, multislice computed tomography, and electron beam tomography are currently being tested for their ability to identify such patients by morphological criteria. In contrast, molecular imaging techniques use radiolabeled molecules to detect functional aspects in atherosclerotic plaques by visualizing their biological activity. Based upon the knowledge about the pathophysiology of atherosclerosis, various studies in vitro and in vivo and the first clinical trials have used different tracers for plaque imaging studies, including radioactive-labeled lipoproteins, components of the coagulation system, cytokines, mediators of the metalloproteinase system, cell adhesion receptors, and even whole cells. This review gives an update on the relevant noninvasive plaque imaging approaches using nuclear imaging techniques to detect atherosclerotic vascular lesions. Radionuclide Imaging: A Molecular Key to the Atherosclerotic Plaque Harald F. Langer, Roland Haubner, Bernd J. Pichler, Meinrad Gawaz Despite primary and secondary prevention, serious cardiovascular events such as unstable angina or myocardial infarction still account for one-third of all deaths worldwide. Therefore, identifying individual patients with vulnerable plaques at high risk for plaque rupture is a central challenge in cardiovascular medicine. Molecular imaging techniques use radiolabeled molecules to detect functional aspects in atherosclerotic plaques by visualizing their biological activity. This review gives an update on the relevant tracers used for plaque imaging studies, including radioactive-labeled cells, lipoproteins, components of the coagulation system, cytokines, mediators of the metalloproteinase system, and cell surface receptors. JF - Journal of the American College of Cardiology AU - Langer, Harald F AU - Haubner, Roland AU - Pichler, Bernd J AU - Gawaz, Meinrad Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 1 EP - 12 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.com] VL - 52 IS - 1 SN - 0735-1097, 0735-1097 KW - Biotechnology and Bioengineering Abstracts KW - plaque imaging KW - atherosclerosis KW - radionuclide imaging KW - vulnerable plaque KW - thrombogenicity KW - Cell surface KW - Coagulation KW - Angina KW - Magnetic resonance imaging KW - Rupture KW - Arteriosclerosis KW - Clinical trials KW - Myocardial infarction KW - Cell adhesion KW - Metalloproteinase KW - Tracers KW - Risk factors KW - Lipoproteins KW - Computed tomography KW - Radioisotopes KW - Cytokines KW - Plaques KW - Vascular system KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20264732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Radionuclide+Imaging%3A+A+Molecular+Key+to+the+Atherosclerotic+Plaque&rft.au=Langer%2C+Harald+F%3BHaubner%2C+Roland%3BPichler%2C+Bernd+J%3BGawaz%2C+Meinrad&rft.aulast=Langer&rft.aufirst=Harald&rft.date=2008-07-01&rft.volume=52&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2008.03.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell surface; Coagulation; Angina; Magnetic resonance imaging; Rupture; Arteriosclerosis; Clinical trials; Myocardial infarction; Cell adhesion; Metalloproteinase; Tracers; Risk factors; Computed tomography; Lipoproteins; Radioisotopes; Cytokines; Plaques; Vascular system DO - http://dx.doi.org/10.1016/j.jacc.2008.03.036 ER - TY - JOUR T1 - Reduced NODAL Signaling Strength via Mutation of Several Pathway Members Including FOXH1 Is Linked to Human Heart Defects and Holoprosencephaly AN - 20263598; 8856789 AB - Abnormalities of embryonic patterning are hypothesized to underlie many common congenital malformations in humans including congenital heart defects (CHDs), left-right disturbances (L-R) or laterality, and holoprosencephaly (HPE). Studies in model organisms suggest that Nodal-like factors provide instructions for key aspects of body axis and germ layer patterning; however, the complex genetics of pathogenic gene variant(s) in humans are poorly understood. Here we report our studies of FOXH1, CFC1, and SMAD2 and summarize our mutational analysis of three additional components in the human NODAL-signaling pathway: NODAL, GDF1, and TDGF1. We identify functionally abnormal gene products throughout the pathway that are clearly associated with CHD, laterality, and HPE. Abnormal gene products are most commonly detected in patients within a narrow spectrum of isolated conotruncal heart defects (minimum 5%-10% of subjects), and far less commonly in isolated laterality or HPE patients ([not, vert, similar]1% for each). The difference in the mutation incidence between these groups is highly significant. We show that apparent gene dosage discrepancies between humans and model organisms can be reconciled by considering a broader combination of sequence variants. Our studies confirm that (1) the genetic vulnerabilities inferred from model organisms with defects in Nodal signaling are indeed analogous to humans; (2) the molecular analysis of an entire signaling pathway is more complete and robust than that of individual genes and presages future studies by whole-genome analysis; and (3) a functional genomics approach is essential to fully appreciate the complex genetic interactions necessary to produce these effects in humans. JF - American Journal of Human Genetics AU - Roessler, Erich AU - Ouspenskaia, Maia V AU - Karkera, Jayaprakash D AU - Velez, Jorge I AU - Kantipong, Amy AU - Lacbawan, Felicitas AU - Bowers, Peter AU - Belmont, John W AU - Towbin, Jeffrey A AU - Goldmuntz, Elizabeth AU - Feldman, Benjamin AU - Muenke, Maximilian AD - Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA, mmuenke@nhgri.nih.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 18 EP - 29 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 83 IS - 11 SN - 0002-9297, 0002-9297 KW - Toxicology Abstracts; Genetics Abstracts KW - Heart KW - Molecular modelling KW - Smad2 protein KW - Models KW - Embryogenesis KW - Holoprosencephaly KW - Gene dosage KW - Congenital defects KW - genomics KW - Mutation KW - Pattern formation KW - Signal transduction KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20263598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Genetics&rft.atitle=Reduced+NODAL+Signaling+Strength+via+Mutation+of+Several+Pathway+Members+Including+FOXH1+Is+Linked+to+Human+Heart+Defects+and+Holoprosencephaly&rft.au=Roessler%2C+Erich%3BOuspenskaia%2C+Maia+V%3BKarkera%2C+Jayaprakash+D%3BVelez%2C+Jorge+I%3BKantipong%2C+Amy%3BLacbawan%2C+Felicitas%3BBowers%2C+Peter%3BBelmont%2C+John+W%3BTowbin%2C+Jeffrey+A%3BGoldmuntz%2C+Elizabeth%3BFeldman%2C+Benjamin%3BMuenke%2C+Maximilian&rft.aulast=Roessler&rft.aufirst=Erich&rft.date=2008-07-01&rft.volume=83&rft.issue=11&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Genetics&rft.issn=00029297&rft_id=info:doi/10.1016%2Fj.ajhg.2008.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Molecular modelling; Embryogenesis; Holoprosencephaly; Gene dosage; Smad2 protein; Congenital defects; genomics; Mutation; Pattern formation; Models; Signal transduction DO - http://dx.doi.org/10.1016/j.ajhg.2008.05.012 ER - TY - JOUR T1 - Biodistribution and Toxicological Safety of Adenovirus Type 5 and Type 35 Vectored Vaccines Against Human Immunodeficiency Virus-1 (HIV-1), Ebola, or Marburg Are Similar Despite Differing Adenovirus Serotype Vector, Manufacturer's Construct, or Gene Inserts AN - 20186209; 10266626 AB - The Vaccine Research Center has developed vaccine candidates for different diseases/infectious agents (including HIV-1, Ebola, and Marburg viruses) built on an adenovirus vector platform, based on adenovirus type 5 or 35. To support clinical development of each vaccine candidate, pre-clinical studies were performed in rabbits to determine where in the body they biodistribute and how rapidly they clear, and to screen for potential toxicities (intrinsic and immunotoxicities). The vaccines biodistribute only to spleen, liver (Ad5 only), and/or iliac lymph node (Ad35 only) and otherwise remain in the site of injection muscle and overlying subcutis. Though ~ 1011 viral particles were inoculated, already by Day 9, all but 103 to 105 genome copies per m g of DNA had cleared from the injection site muscle. By three months, the adenovector was cleared with, at most, a few animals retaining a small number of copies in the injection site, spleen (Ad5), or iliac lymph node (Ad35). This pattern of limited biodistribution and extensive clearance is consistent regardless of differences in adenovector type (Ad5 or 35), manufacturer's construct and production methods, or gene-insert. Repeated dose toxicology studies identified treatment-related toxicities confined primarily to the sites of injection, in certain clinical pathology parameters, and in body temperatures (Ad5 vectors) and food consumption immediately post-inoculation. Systemic reactogenicity and reactogenicity at the sites of injection demonstrated reversibility. These data demonstrate the safety and suitability for investigational human use of Ad5 or Ad35 adenovector-based vaccine candidates at doses of up to 2 X 1011 given intramuscularly to prevent various infectious diseases. JF - Journal of Immunotoxicology AU - Sheets, Rebecca AU - Stein, Judith AU - Bailer, Robert AU - Koup, Richard AU - Andrews, Charla AU - Nason, Martha AU - He, Bin AU - Koo, Edward AU - Trotter, Holly AU - Duffy, Chris AU - Manetz, T Scott AU - Gomez, Phillip AD - Vaccine Research Center, NIH/NIAID, Bethesda, Maryland, USA Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 315 EP - 335 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 5 IS - 3 SN - 1547-691X, 1547-691X KW - Toxicology Abstracts; Virology & AIDS Abstracts; Genetics Abstracts; Immunology Abstracts KW - Genomes KW - Marburg virus KW - Data processing KW - Serotypes KW - Body temperature KW - Adenovirus KW - Immunodeficiency KW - Muscles KW - Spleen KW - Ebola virus KW - Toxicity KW - Lymph nodes KW - Expression vectors KW - Food consumption KW - Immunotoxicity KW - Infectious diseases KW - Human immunodeficiency virus 1 KW - Liver KW - DNA KW - Vaccines KW - Immune response KW - G 07720:Immunogenetics KW - V 22360:AIDS and HIV KW - X 24310:Pharmaceuticals KW - F 06955:Immunomodulation & Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20186209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunotoxicology&rft.atitle=Biodistribution+and+Toxicological+Safety+of+Adenovirus+Type+5+and+Type+35+Vectored+Vaccines+Against+Human+Immunodeficiency+Virus-1+%28HIV-1%29%2C+Ebola%2C+or+Marburg+Are+Similar+Despite+Differing+Adenovirus+Serotype+Vector%2C+Manufacturer%27s+Construct%2C+or+Gene+Inserts&rft.au=Sheets%2C+Rebecca%3BStein%2C+Judith%3BBailer%2C+Robert%3BKoup%2C+Richard%3BAndrews%2C+Charla%3BNason%2C+Martha%3BHe%2C+Bin%3BKoo%2C+Edward%3BTrotter%2C+Holly%3BDuffy%2C+Chris%3BManetz%2C+T+Scott%3BGomez%2C+Phillip&rft.aulast=Sheets&rft.aufirst=Rebecca&rft.date=2008-07-01&rft.volume=5&rft.issue=3&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunotoxicology&rft.issn=1547691X&rft_id=info:doi/10.1080%2F15376510802312464 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Genomes; Serotypes; Data processing; Body temperature; Muscles; Immunodeficiency; Spleen; Toxicity; Lymph nodes; Expression vectors; Food consumption; Immunotoxicity; Infectious diseases; DNA; Liver; Immune response; Vaccines; Marburg virus; Human immunodeficiency virus 1; Adenovirus; Ebola virus DO - http://dx.doi.org/10.1080/15376510802312464 ER - TY - JOUR T1 - A diversity profile of the human skin microbiota AN - 20143753; 8338594 AB - The many layers and structures of the skin serve as elaborate hosts to microbes, including a diversity of commensal and pathogenic bacteria that contribute to both human health and disease. To determine the complexity and identity of the microbes inhabiting the skin, we sequenced bacterial 16S small-subunit ribosomal RNA genes isolated from the inner elbow of five healthy human subjects. This analysis revealed 113 operational taxonomic units (OTUs; "phylotypes") at the level of 97% similarity that belong to six bacterial divisions. To survey all depths of the skin, we sampled using three methods: swab, scrape, and punch biopsy. Proteobacteria dominated the skin microbiota at all depths of sampling. Interpersonal variation is approximately equal to intrapersonal variation when considering bacterial community membership and structure. Finally, we report strong similarities in the complexity and identity of mouse and human skin microbiota. This study of healthy human skin microbiota will serve to direct future research addressing the role of skin microbiota in health and disease, and metagenomic projects addressing the complex physiological interactions between the skin and the microbes that inhabit this environment. JF - Genome Research AU - Grice, Elizabeth A AU - Kong, Heidi H AU - Renaud, Gabriel AU - Young, Alice C AU - Bouffard, Gerard G AU - Blakesley, Robert W AU - Wolfsberg, Tyra G AU - Turner, Maria L AU - Segre, Julia A AD - Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. NIH Intramural Sequencing Center (NISC), National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 1043 EP - 1050 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 18 IS - 7 SN - 1088-9051, 1088-9051 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Skin KW - Commensals KW - Biopsy KW - Sampling KW - rRNA 16S KW - Elbow KW - Proteobacteria KW - J 02310:Genetics & Taxonomy KW - A 01450:Environmental Pollution & Waste Treatment KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20143753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=A+diversity+profile+of+the+human+skin+microbiota&rft.au=Grice%2C+Elizabeth+A%3BKong%2C+Heidi+H%3BRenaud%2C+Gabriel%3BYoung%2C+Alice+C%3BBouffard%2C+Gerard+G%3BBlakesley%2C+Robert+W%3BWolfsberg%2C+Tyra+G%3BTurner%2C+Maria+L%3BSegre%2C+Julia+A&rft.aulast=Grice&rft.aufirst=Elizabeth&rft.date=2008-07-01&rft.volume=18&rft.issue=7&rft.spage=1043&rft.isbn=&rft.btitle=&rft.title=Genome+Research&rft.issn=10889051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Skin; Commensals; Biopsy; Sampling; Elbow; rRNA 16S; Proteobacteria ER - TY - JOUR T1 - Biosynthesis and Recycling of Nicotinamide Cofactors in Mycobacterium tuberculosis: AN ESSENTIAL ROLE FOR NAD IN NONREPLICATING BACILLI AN - 20096959; 8340039 AB - Despite the presence of genes that apparently encode NAD salvage-specific enzymes in its genome, it has been previously thought that Mycobacterium tuberculosis can only synthesize NAD de novo. Transcriptional analysis of the de novo synthesis and putative salvage pathway genes revealed an up-regulation of the salvage pathway genes in vivo and in vitro under conditions of hypoxia. [ super(14)C]Nicotinamide incorporation assays in M. tuberculosis isolated directly from the lungs of infected mice or from infected macrophages revealed that incorporation of exogenous nicotinamide was very efficient in in vivo-adapted cells, in contrast to cells grown aerobically in vitro. Two putative nicotinic acid phosphoribosyltransferases, PncB1 (Rv1330c) and PncB2 (Rv0573c), were examined by a combination of in vitro enzymatic activity assays and allelic exchange studies. These studies revealed that both play a role in cofactor salvage. Mutants in the de novo pathway died upon removal of exogenous nicotinamide during active replication in vitro. Cell death is induced by both cofactor starvation and disruption of cellular redox homeostasis as electron transport is impaired by limiting NAD. Inhibitors of NAD synthetase, an essential enzyme common to both recycling and de novo synthesis pathways, displayed the same bactericidal effect as sudden NAD starvation of the de novo pathway mutant in both actively growing and nonreplicating M. tuberculosis. These studies demonstrate the plasticity of the organism in maintaining NAD levels and establish that the two enzymes of the universal pathway are attractive chemotherapeutic targets for active as well as latent tuberculosis. JF - Journal of Biological Chemistry AU - Boshoff, Helena IM AU - Xu, Xia AU - Tahlan, Kapil AU - Dowd, Cynthia S AU - Pethe, Kevin AU - Camacho, Luis R AU - Park, Tae-Ho AU - Yun, Chang-Soo AU - Schnappinger, Dirk AU - Ehrt, Sabine AU - Williams, Kerstin J AU - Barry, Clifton EIII AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, Novartis Institute for Tropical Diseases, Singapore 138670, Singapore, Center for Anti-Infective Agents Research, Drug Discovery Division, Korea Research Institute of Chemical Technology, 100 Jang-Dong, Daejeon, 305-600, Korea, the Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, and the Department of Microbiology, Centre for Molecular Microbiology and Infection, 3.40 Flowers Building, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 19329 EP - 19341 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 28 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Macrophages KW - Starvation KW - Genomes KW - Bacilli KW - nicotinamide KW - Replication KW - phosphoribosyltransferase KW - Transcription KW - Homeostasis KW - Nicotinic acid KW - Recycling KW - Cell death KW - Cofactors KW - NAD KW - Lung KW - Hypoxia KW - Tuberculosis KW - Enzymatic activity KW - Electron transport KW - Mycobacterium tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - N 14830:RNA KW - G 07770:Bacteria KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20096959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Biosynthesis+and+Recycling+of+Nicotinamide+Cofactors+in+Mycobacterium+tuberculosis%3A+AN+ESSENTIAL+ROLE+FOR+NAD+IN+NONREPLICATING+BACILLI&rft.au=Boshoff%2C+Helena+IM%3BXu%2C+Xia%3BTahlan%2C+Kapil%3BDowd%2C+Cynthia+S%3BPethe%2C+Kevin%3BCamacho%2C+Luis+R%3BPark%2C+Tae-Ho%3BYun%2C+Chang-Soo%3BSchnappinger%2C+Dirk%3BEhrt%2C+Sabine%3BWilliams%2C+Kerstin+J%3BBarry%2C+Clifton+EIII&rft.aulast=Boshoff&rft.aufirst=Helena&rft.date=2008-07-01&rft.volume=283&rft.issue=28&rft.spage=19329&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Starvation; Macrophages; Bacilli; Replication; nicotinamide; phosphoribosyltransferase; Transcription; Homeostasis; Recycling; Nicotinic acid; Cell death; Cofactors; NAD; Lung; Hypoxia; Tuberculosis; Enzymatic activity; Electron transport; Mycobacterium tuberculosis ER - TY - JOUR T1 - Pictures of microbiology - The Biofilm Imaging Facility under Dr. David C. White AN - 20013061; 8258156 AB - This contribution honoring David C. White (DC) summarizes the five years I interacted with him on a daily basis in his laboratory. Over this time we worked on many different projects all tied together by the unifying principle now recognized as central to bacterial life in nature: biofilms. My goal is to convey some of the excitement and joy of working with DC and, from my perspective, that means telling how the Biofilm Imaging Facility at the Center for Environmental Biotechnology (CEB) came into existence and describing some of the projects on which DC and I worked. JF - Journal of Microbiological Methods AU - Palmer Jr, RJ AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health Bldg. 30, Room 310 30 Convent Drive Bethesda MD 20892, United States, rjpalmer@mail.nih.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 5 EP - 9 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 74 IS - 1 SN - 0167-7012, 0167-7012 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Biofilms KW - imaging KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20013061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=Pictures+of+microbiology+-+The+Biofilm+Imaging+Facility+under+Dr.+David+C.+White&rft.au=Palmer+Jr%2C+RJ&rft.aulast=Palmer+Jr&rft.aufirst=RJ&rft.date=2008-07-01&rft.volume=74&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2007.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biofilms; imaging DO - http://dx.doi.org/10.1016/j.mimet.2007.07.003 ER - TY - JOUR T1 - Incomplete Protection against Simian Immunodeficiency Virus Vaginal Transmission in Rhesus Macaques by a Topical Antiviral Agent Revealed by Repeat Challenges AN - 19895046; 8303741 AB - The rising prevalence of human immunodeficiency virus type 1 (HIV-1) infection in women, especially in resource-limited settings, accentuates the need for accessible, inexpensive, and female-controlled preexposure prophylaxis strategies to prevent mucosal transmission of the virus. While many compounds can inactivate HIV-1 in vitro, evaluation in animal models for mucosal transmission of virus may help identify which approaches will be effective in vivo. Macaques challenged intravaginally with pathogenic simian immunodeficiency virus (SIV sub(mac251)) provide a model to preclinically evaluate candidate microbicides. 2-Hydroxypropyl-b-cyclodextrin (BCD) prevents HIV-1 and SIV infection of target cells at subtoxic doses in vitro. Consistent with these findings, intravaginal challenge of macaques with SIV sub(mac251) preincubated with BCD prevented mucosal transmission, as measured by plasma viremia and antiviral antibodies, through 10 weeks postchallenge. In an initial challenge, BCD applied topically prior to SIV sub(mac251) prevented intravaginal transmission of virus compared to controls (P < 0.0001). However, upon a second virus challenge following BCD pretreatment, the majority of the previously protected animals became infected. The mechanism through which animals become infected at a frequency similar to that of controls after prior exposure to BCD and SIV sub(mac251) in subsequent intravaginal virus challenges (P = 0.63), despite the potent antiviral properties of BCD, remains to be determined. These results highlight the unpredictability of antiviral compounds as topical microbicides and suggest that repeated exposures to candidate treatments should be considered for in vivo evaluation. JF - Journal of Virology AU - Ambrose, Zandrea AU - Compton, Lara AU - Piatak, Michael Jr AU - Lu, Ding AU - Alvord, WGregory AU - Lubomirski, Mariusz S AU - Hildreth, James EK AU - Lifson, Jeffrey D AU - Miller, Christopher J AU - KewalRamani, Vineet N AD - HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland 21702. California National Primate Research Center and Center for Comparative Medicine, University of California at Davis, Davis, California 95616. AIDS Vaccine Program, SAIC Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702. Data Management Services, Inc., National Cancer Institute, Frederick, Maryland 21702. Meharry Medical College, Nashville, Tennessee 37208 Y1 - 2008/07/01/ PY - 2008 DA - 2008 Jul 01 SP - 6591 EP - 6599 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 82 IS - 13 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Mucosa KW - Animal models KW - Infection KW - Antiviral activity KW - Disease transmission KW - Antibodies KW - Antiviral agents KW - Human immunodeficiency virus 1 KW - Vagina KW - Prophylaxis KW - Macaca mulatta KW - Viremia KW - Simian immunodeficiency virus KW - microbicides KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Incomplete+Protection+against+Simian+Immunodeficiency+Virus+Vaginal+Transmission+in+Rhesus+Macaques+by+a+Topical+Antiviral+Agent+Revealed+by+Repeat+Challenges&rft.au=Ambrose%2C+Zandrea%3BCompton%2C+Lara%3BPiatak%2C+Michael+Jr%3BLu%2C+Ding%3BAlvord%2C+WGregory%3BLubomirski%2C+Mariusz+S%3BHildreth%2C+James+EK%3BLifson%2C+Jeffrey+D%3BMiller%2C+Christopher+J%3BKewalRamani%2C+Vineet+N&rft.aulast=Ambrose&rft.aufirst=Zandrea&rft.date=2008-07-01&rft.volume=82&rft.issue=13&rft.spage=6591&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antibodies; Antiviral agents; Vagina; Mucosa; Animal models; Prophylaxis; Viremia; Antiviral activity; Infection; microbicides; Disease transmission; Human immunodeficiency virus 1; Macaca mulatta; Simian immunodeficiency virus ER - TY - JOUR T1 - Pandemic and seasonal influenza: therapeutic challenges AN - 19793474; 8414771 AB - Influenza A viruses cause significant morbidity and mortality annually, and the threat of a pandemic underscores the need for new therapeutic strategies. Here, we briefly discuss novel antiviral agents under investigation, the limitations of current antiviral therapy and stress the importance of secondary bacterial infections in seasonal and pandemic influenza. Additionally, the lack of new antibiotics available to treat increasingly drug resistant organisms such as methicillin-resistant Staphylococcus aureus, pneumococci, Acinetobacter, extended spectrum beta-lactamase producing gram negative bacteria and Clostridium difficile is highlighted as an important component of influenza treatment and pandemic preparedness. Addressing these problems will require a multidisciplinary approach, which includes the development of novel antivirals and new antibiotics, as well as a better understanding of the role secondary infections play on the morbidity and mortality of influenza infection. JF - Drug Discovery Today AU - Memoli, MJ AU - Morens, D M AU - Taubenberger, J K AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, memolim@niaid.nih.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 590 EP - 595 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 13 IS - 13-14 SN - 1359-6446, 1359-6446 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Mortality KW - Drug resistance KW - Influenza A KW - Antibiotics KW - Secondary infection KW - Morbidity KW - pandemics KW - Acinetobacter KW - Antiviral agents KW - Gram-negative bacteria KW - Clostridium difficile KW - Staphylococcus aureus KW - W 30915:Pharmaceuticals & Vaccines KW - V 22400:Human Diseases KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19793474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Pandemic+and+seasonal+influenza%3A+therapeutic+challenges&rft.au=Memoli%2C+MJ%3BMorens%2C+D+M%3BTaubenberger%2C+J+K&rft.aulast=Memoli&rft.aufirst=MJ&rft.date=2008-07-01&rft.volume=13&rft.issue=13-14&rft.spage=590&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2008.03.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; pandemics; Antiviral agents; Gram-negative bacteria; Influenza A; Drug resistance; Antibiotics; Secondary infection; Morbidity; Acinetobacter; Clostridium difficile; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.drudis.2008.03.024 ER - TY - JOUR T1 - NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly AN - 19717406; 8405677 AB - The Negative Elongation Factor (NELF) is a transcription regulatory complex that induces stalling of RNA polymerase II (Pol II) during early transcription elongation and represses expression of several genes studied to date, including Drosophila Hsp70, mammalian proto-oncogene junB, and HIV RNA. To determine the full spectrum of NELF target genes in Drosophila, we performed a microarray analysis of S2 cells depleted of NELF and discovered that NELF RNAi affects many rapidly inducible genes involved in cellular responses to stimuli. Surprisingly, only one-third of NELF target genes were, like Hsp70, up-regulated by NELF-depletion, whereas the majority of target genes showed decreased expression levels upon NELF RNAi. Our data reveal that the presence of stalled Pol II at this latter group of genes enhances gene expression by maintaining a permissive chromatin architecture around the promoter-proximal region, and that loss of Pol II stalling at these promoters is accompanied by a significant increase in nucleosome occupancy and a decrease in histone H3 Lys 4 trimethylation. These findings identify a novel, positive role for stalled Pol II in regulating gene expression and suggest that there is a dynamic interplay between stalled Pol II and chromatin structure. JF - Genes & Development AU - Gilchrist, Daniel A AU - Nechaev, Sergei AU - Lee, Chanhyo AU - Ghosh, Saikat Kumar B AU - Collins, Jennifer B AU - Li, Leping AU - Gilmour, David S AU - Adelman, Karen AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Department of Biochemistry and Molecular Biology, Center for Gene Regulation, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. Microarray Group, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 1921 EP - 1933 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 22 IS - 14 SN - 0890-9369, 0890-9369 KW - Entomology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Data processing KW - Chromatin KW - DNA microarrays KW - Gene expression KW - Promoters KW - Nucleosomes KW - DNA-directed RNA polymerase KW - Hsp70 protein KW - Human immunodeficiency virus KW - Transcription elongation KW - JunB protein KW - RNA-mediated interference KW - Histone H3 KW - Drosophila KW - Methylation KW - Proto-oncogenes KW - Z 05300:General KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19717406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=NELF-mediated+stalling+of+Pol+II+can+enhance+gene+expression+by+blocking+promoter-proximal+nucleosome+assembly&rft.au=Gilchrist%2C+Daniel+A%3BNechaev%2C+Sergei%3BLee%2C+Chanhyo%3BGhosh%2C+Saikat+Kumar+B%3BCollins%2C+Jennifer+B%3BLi%2C+Leping%3BGilmour%2C+David+S%3BAdelman%2C+Karen&rft.aulast=Gilchrist&rft.aufirst=Daniel&rft.date=2008-07-01&rft.volume=22&rft.issue=14&rft.spage=1921&rft.isbn=&rft.btitle=&rft.title=Genes+%26+Development&rft.issn=08909369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Chromatin; DNA microarrays; Gene expression; Promoters; DNA-directed RNA polymerase; Nucleosomes; Hsp70 protein; Transcription elongation; JunB protein; RNA-mediated interference; Histone H3; Methylation; Proto-oncogenes; Human immunodeficiency virus; Drosophila ER - TY - JOUR T1 - Mammalian cell expression of an active site mutant of Pseudomonas exotoxin disrupts LRP1 maturation AN - 19650049; 8427520 AB - Low density lipoprotein receptor-related protein 1, (LRP1) is a large multifunctional receptor that binds more than 25 physiologic ligands. In addition, it functions as the surface receptor for several Rhinoviruses, HIV-tat and Pseudomonas exotoxin (PE). We report that the expression of PE within mammalian cells can serve as a probe of LRP1 maturation and functionality. To avoid cell killing, an enzymatically inactive form of the toxin (PE Delta 553) was expressed. A permanent cell line (termed CY301) was established whereby PE Delta 553 was expressed continually into the ER of CHO cells. CY301 cells were 100-fold resistant to exogenously added active PE but exhibited no cross-resistance to other toxins. Our studies indicate that PE Delta 553 bound to immature LRP1 in the ER, prevented its maturation to the cell surface and thereby produced a toxin resistant phenotype. By confocal microscopy, cell-associated PE Delta 553 was localized to the ER and co-localized with LRP1. Further characterization of CY301 cells indicated that RAP, the chaperone that aids in LRP1 folding, was released to the growth media. Thus the intracellular expression of PEA553 appears to be a valuable probe of LRP1 maturation and trafficking. JF - Journal of Biomedical Science AU - Pastrana, D V AU - Yun, CH AU - McKee, M L AU - FitzGerald, D J AD - Biotherapy Section, LMB, 37/5124, 37 Convent Dr. MSC 4264, Bethesda, MD 20892-4264, USA, djpf@helix.nih.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 427 EP - 439 VL - 15 IS - 4 SN - 1021-7770, 1021-7770 KW - Microbiology Abstracts B: Bacteriology KW - Cell surface KW - Probes KW - Pseudomonas KW - Toxins KW - Exotoxins KW - Mammalian cells KW - Human immunodeficiency virus KW - Confocal microscopy KW - Lipoproteins KW - Rhinovirus KW - Chaperones KW - Cross-resistance KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19650049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Science&rft.atitle=Mammalian+cell+expression+of+an+active+site+mutant+of+Pseudomonas+exotoxin+disrupts+LRP1+maturation&rft.au=Pastrana%2C+D+V%3BYun%2C+CH%3BMcKee%2C+M+L%3BFitzGerald%2C+D+J&rft.aulast=Pastrana&rft.aufirst=D&rft.date=2008-07-01&rft.volume=15&rft.issue=4&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Science&rft.issn=10217770&rft_id=info:doi/10.1007%2Fs11373-008-9245-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; Mammalian cells; Lipoproteins; Confocal microscopy; Probes; Chaperones; Cross-resistance; Exotoxins; Toxins; Human immunodeficiency virus; Rhinovirus; Pseudomonas DO - http://dx.doi.org/10.1007/s11373-008-9245-z ER - TY - JOUR T1 - Moraxella catarrhalis lipooligosaccharide selectively upregulates ICAM-1 expression on human monocytes and stimulates adjacent naive monocytes to produce TNF-a through cellular cross-talk AN - 19647390; 8383821 AB - To elucidate the role of Moraxella catarrhalis lipooligosaccharide (LOS) in otitis media with effusion (OME), the effects of LOS on adhesion antigens of human monocytes were investigated. M. catarrhalis LOS selectively enhanced intercellular adhesion molecule 1 (ICAM-1 or CD54) expression on human monocytes by significantly increasing both the surface expression intensity and the percentage of ICAM-1+ cells. ICAM-1 upregulation on human monocytes by the LOS required surface CD14, TLR4, NF-B p65 and c-Jun N-terminal kinase (JNK) activity. Our study also revealed that the LOS-induced surface ICAM-1 expression was partially mediated through a TNF-a dependent autocrine mechanism and could be further augmented by lipopolysaccharide-binding protein in serum. In addition, M. catarrhalis LOS also stimulated human monocytes to produce pro-inflammatory cytokines in both TLR4- and CD14-dependent pathways. Our results also indicated that enhanced surface ICAM-1 expression on monocytes may hinder their adherence to the lung epithelial monolayer. Furthermore, the LOS-activated human monocytes secreted a significantly high level of IL-8, and could stimulate adjacent naive monocytes to produce TNF-a which was partially mediated via membrane ICAM-1 and IL-8-IL-8RA. These results suggest that M. catarrhalis LOS could induce excessive middle ear inflammation through a cellular cross-talk mechanism during OME. JF - Cellular Microbiology AU - Xie, Hang AU - Gu, Xin-Xing AD - Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA, guxx@nidcd.nih.gov Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 1453 EP - 1467 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 10 IS - 7 SN - 1462-5814, 1462-5814 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - c-Jun amino-terminal kinase KW - Middle ear KW - Moraxella catarrhalis KW - Effusion KW - Tumor necrosis factor-a KW - CD14 antigen KW - Lipopolysaccharide-binding protein KW - Interleukin 8 KW - Lipooligosaccharides KW - Inflammation KW - Autocrine signalling KW - Lung KW - Otitis media KW - NF-B protein KW - intercellular adhesion molecule 1 KW - Monocytes KW - TLR4 protein KW - Toll-like receptors KW - J 02320:Cell Biology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19647390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Moraxella+catarrhalis+lipooligosaccharide+selectively+upregulates+ICAM-1+expression+on+human+monocytes+and+stimulates+adjacent+naive+monocytes+to+produce+TNF-a+through+cellular+cross-talk&rft.au=Xie%2C+Hang%3BGu%2C+Xin-Xing&rft.aulast=Xie&rft.aufirst=Hang&rft.date=2008-07-01&rft.volume=10&rft.issue=7&rft.spage=1453&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2008.01138.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - c-Jun amino-terminal kinase; Middle ear; Effusion; CD14 antigen; Tumor necrosis factor-a; Lipopolysaccharide-binding protein; Interleukin 8; Inflammation; Lipooligosaccharides; Autocrine signalling; Lung; Otitis media; intercellular adhesion molecule 1; NF-B protein; Monocytes; TLR4 protein; Toll-like receptors; Moraxella catarrhalis DO - http://dx.doi.org/10.1111/j.1462-5822.2008.01138.x ER - TY - JOUR T1 - OC102: The clinical significance of early (< 20 weeks) versus late (20-24 weeks) detection of a sonographic short cervix in asymptomatic women AN - 19274274; 8635793 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Vaisbuch, E AU - Romero, R AU - Erez, O AU - Kusanovic, J P AU - Gotsch, F AU - Mazaki-Tovi, S AU - Romero, V AU - Ward, C AU - Chaiworapongsa, T AU - Mittal, P AU - Sorokin, Y AU - Hassan, S AD - Perinatology Research Branch, NICHD/NIH/DHHS, Detroit, United States Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 276 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 32 IS - 1 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Gynecology KW - Cervix KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19274274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OC102%3A+The+clinical+significance+of+early+%28%26lt%3B+20+weeks%29+versus+late+%2820-24+weeks%29+detection+of+a+sonographic+short+cervix+in+asymptomatic+women&rft.au=Vaisbuch%2C+E%3BRomero%2C+R%3BErez%2C+O%3BKusanovic%2C+J+P%3BGotsch%2C+F%3BMazaki-Tovi%2C+S%3BRomero%2C+V%3BWard%2C+C%3BChaiworapongsa%2C+T%3BMittal%2C+P%3BSorokin%2C+Y%3BHassan%2C+S&rft.aulast=Vaisbuch&rft.aufirst=E&rft.date=2008-07-01&rft.volume=32&rft.issue=1&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.5510 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Cervix; Gynecology; Ultrasound DO - http://dx.doi.org/10.1002/uog.5510 ER - TY - JOUR T1 - Saccharide/protein conjugate vaccines for Bordetella species: Preparation of saccharide, development of new conjugation procedures, and physico-chemical and immunological characterization of the conjugates AN - 1500773743; 19046721 AB - Bordetellae are Gram-negative bacilli causing respiratory tract infections of mammals and birds. Clinically important are , and . vaccines have been successful in preventing pertussis in infants and children. Veterinary vaccines against are available, but their efficacy and mode of action are not established. There is no vaccine against . Based on the concept that immunity to non-capsulated Gram-negative bacteria may be conferred by serum IgG anti-LPS we studied chemical, serological and immunological properties of the O-specific polysaccharides (O-SP) of and obtained by different degradation procedures. One type of the and two types of O-SP were recognized based on the structure of their non-reducing end saccharide; no cross-reaction between the two types was observed. Competitive inhibition assays showed the immunodominance of the non-reducing end of these O-SP. Conjugates of and O-SP were prepared by two methods: using the anhydro-Kdo residue exposed by mild acid hydrolysis of the LPS or the 2,5-anhydromannose residue exposed by deamination of the core glucosamine of the LPS, for binding to an aminooxylated protein. Both coupling methods were carried out at a neutral pH, room temperature, and in a short time. All conjugates, injected as saline solutions at a fraction of an estimated human dose, induced antibodies in mice to the homologous O-SP. These methodologies can be applied to prepare O-SP-based vaccines against other Gram-negative bacteria. JF - Vaccine AU - Kubler-Kielb, Joanna AU - Vinogradov, Evgeny AU - Ben-Menachem, Gil AU - Pozsgay, Vince AU - Robbins, John B AU - Schneerson, Rachel AD - National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 2008/07// PY - 2008 DA - Jul 2008 SP - 3587 EP - 3593 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 26 IS - 29 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Temperature effects KW - Pertussis KW - Conjugation KW - Cross-reaction KW - Glucosamine KW - Deamination KW - Immunity KW - Children KW - Infection KW - Polysaccharides KW - Coupling methods KW - Hydrolysis KW - Respiratory tract diseases KW - Bordetella KW - Gram-negative bacilli KW - Gram-negative bacteria KW - Immunoglobulin G KW - Lipopolysaccharides KW - Vaccines KW - pH effects KW - Immunodominance KW - Infants KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500773743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Saccharide%2Fprotein+conjugate+vaccines+for+Bordetella+species%3A+Preparation+of+saccharide%2C+development+of+new+conjugation+procedures%2C+and+physico-chemical+and+immunological+characterization+of+the+conjugates&rft.au=Kubler-Kielb%2C+Joanna%3BVinogradov%2C+Evgeny%3BBen-Menachem%2C+Gil%3BPozsgay%2C+Vince%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Kubler-Kielb&rft.aufirst=Joanna&rft.date=2008-07-01&rft.volume=26&rft.issue=29&rft.spage=3587&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.04.079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Temperature effects; Pertussis; Conjugation; Cross-reaction; Glucosamine; Deamination; Immunity; Polysaccharides; Infection; Children; Hydrolysis; Coupling methods; Respiratory tract diseases; Gram-negative bacilli; Gram-negative bacteria; Immunoglobulin G; Lipopolysaccharides; Vaccines; pH effects; Infants; Immunodominance; Bordetella DO - http://dx.doi.org/10.1016/j.vaccine.2008.04.079 ER - TY - JOUR T1 - Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. AN - 69280292; 18591428 AB - Gross chromosomal rearrangement (GCR) is a type of genomic instability associated with many cancers. In yeast, multiple pathways cooperate to suppress GCR. In a screen for genes that promote GCR, we identified MPH1, which encodes a 3'-5' DNA helicase. Overexpression of Mph1p in yeast results in decreased efficiency of homologous recombination (HR) as well as delayed Rad51p recruitment to double-strand breaks (DSBs), which suggests that Mph1p promotes GCR by partially suppressing HR. A function for Mph1p in suppression of HR is further supported by the observation that deletion of both mph1 and srs2 synergistically sensitize cells to methyl methanesulfonate-induced DNA damage. The GCR-promoting activity of Mph1p appears to depend on its interaction with replication protein A (RPA). Consistent with this observation, excess Mph1p stabilizes RPA at DSBs. Furthermore, spontaneous RPA foci at DSBs are destabilized by the mph1Delta mutation. Therefore, Mph1p promotes GCR formation by partially suppressing HR, likely through its interaction with RPA. JF - The Journal of cell biology AU - Banerjee, Soma AU - Smith, Stephanie AU - Oum, Ji-Hyun AU - Liaw, Hung-Jiun AU - Hwang, Ji-Young AU - Sikdar, Nilabja AU - Motegi, Akira AU - Lee, Sang Eun AU - Myung, Kyungjae AD - Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/06/30/ PY - 2008 DA - 2008 Jun 30 SP - 1083 EP - 1093 VL - 181 IS - 7 KW - Replication Protein A KW - 0 KW - Saccharomyces cerevisiae Proteins KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - MPH1 protein, S cerevisiae KW - DEAD-box RNA Helicases KW - EC 3.6.4.13 KW - Index Medicus KW - Amino Acid Motifs KW - Protein Binding -- drug effects KW - Adenosine Triphosphatases -- metabolism KW - Mutation -- genetics KW - Replication Protein A -- metabolism KW - Methyl Methanesulfonate -- pharmacology KW - Saccharomyces cerevisiae -- genetics KW - Chromosomes, Fungal -- genetics KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - DEAD-box RNA Helicases -- chemistry KW - DEAD-box RNA Helicases -- metabolism KW - Recombination, Genetic -- drug effects KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Saccharomyces cerevisiae -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69280292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Mph1p+promotes+gross+chromosomal+rearrangement+through+partial+inhibition+of+homologous+recombination.&rft.au=Banerjee%2C+Soma%3BSmith%2C+Stephanie%3BOum%2C+Ji-Hyun%3BLiaw%2C+Hung-Jiun%3BHwang%2C+Ji-Young%3BSikdar%2C+Nilabja%3BMotegi%2C+Akira%3BLee%2C+Sang+Eun%3BMyung%2C+Kyungjae&rft.aulast=Banerjee&rft.aufirst=Soma&rft.date=2008-06-30&rft.volume=181&rft.issue=7&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=1540-8140&rft_id=info:doi/10.1083%2Fjcb.200711146 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-17 N1 - Date created - 2008-07-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Soc Trans. 2005 Dec;33(Pt 6):1456-9 [16246145] Mol Cell. 2002 May;9(5):1067-78 [12049742] Cell. 2000 Feb 18;100(4):479-89 [10693764] Curr Biol. 2000 Apr 20;10(8):487-90 [10801419] Genetics. 2000 Jul;155(3):1069-81 [10880470] Science. 2000 Aug 4;289(5480):771-4 [10926538] Nat Genet. 2001 Jan;27(1):113-6 [11138010] Cell. 2001 Feb 9;104(3):397-408 [11239397] Nature. 2001 Jun 28;411(6841):1073-6 [11429610] Science. 2002 Jul 26;297(5581):552-7 [12142524] Genes Dev. 2002 Oct 15;16(20):2639-49 [12381663] Microbiol Mol Biol Rev. 2002 Dec;66(4):630-70, table of contents [12456786] Nature. 2003 May 15;423(6937):305-9 [12748644] Nature. 2003 May 15;423(6937):309-12 [12748645] Science. 2004 Feb 6;303(5659):808-13 [14764870] J Biol Chem. 2004 Apr 30;279(18):18099-102 [15023996] Genetics. 2004 Apr;166(4):1673-86 [15126389] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9039-44 [15184655] Mol Cell Biol. 2004 Aug;24(16):7082-90 [15282308] Cell. 2004 Sep 17;118(6):699-713 [15369670] Cell. 1976 Sep;9(1):91-9 [788919] Genetics. 1989 Dec;123(4):683-94 [2558957] Cell. 1994 Jan 14;76(1):145-55 [8287473] Mol Cell Biol. 1995 Mar;15(3):1620-31 [7862153] Genetics. 1997 Oct;147(2):399-407 [9335581] J Biol Chem. 2004 Dec 17;279(51):53175-85 [15485882] Semin Cancer Biol. 2005 Feb;15(1):1 [15613282] Semin Cancer Biol. 2005 Feb;15(1):3-12 [15613283] J Biol Chem. 2005 Mar 4;280(9):7854-60 [15634678] Mol Cell Biol. 2005 May;25(10):3934-44 [15870268] Genetics. 2005 Apr;169(4):1927-37 [15687264] Nat Genet. 2005 Sep;37(9):958-63 [16116422] Nat Genet. 2005 Sep;37(9):931-3 [16116424] Nat Struct Mol Biol. 2005 Sep;12(9):763-71 [16116434] Mol Cell Biol. 2006 Feb;26(4):1424-33 [16449653] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1816-21 [16446442] Mol Cell Biol. 2006 Apr;26(7):2490-500 [16537895] Nature. 2006 Mar 30;440(7084):631-6 [16429126] Mol Cell Biol. 2006 Jul;26(14):5406-20 [16809776] Methods. 2007 Feb;41(2):168-76 [17189859] Nat Genet. 2007 Feb;39(2):199-206 [17206143] Mol Cell. 2008 Jan 18;29(1):141-8 [18206976] J Genet. 1949 Dec;49(3):264-85 [24536673] Genes Dev. 2005 Dec 15;19(24):2925-40 [16357213] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1083/jcb.200711146 ER - TY - JOUR T1 - Chlamydia trachomatis tarp is phosphorylated by src family tyrosine kinases. AN - 70737188; 18442471 AB - The translocated actin recruiting phosphoprotein (Tarp) is injected into the cytosol shortly after Chlamydia trachomatis attachment to a target cell and subsequently phosphorylated by an unidentified tyrosine kinase. A role for Tarp phosphorylation in bacterial entry is unknown. In this study, recombinant C. trachomatis Tarp was employed to identify the host cell kinase(s) required for phosphorylation. Each tyrosine rich repeat of L2 Tarp harbors a sequence similar to a Src and Abl kinase consensus target. Furthermore, purified p60-src, Yes, Fyn, and Abl kinases were able to phosphorylate Tarp. Mutagenesis of potential tyrosines within a single tyrosine rich repeat peptide indicated that both Src and Abl kinases phosphorylate the same residues suggesting that C. trachomatis Tarp may serve as a substrate for multiple host cell kinases. Surprisingly, chemical inhibition of Src and Abl kinases prevented Tarp phosphorylation in culture and had no measurable effect on bacterial entry into host cells. JF - Biochemical and biophysical research communications AU - Jewett, Travis J AU - Dooley, Cheryl A AU - Mead, David J AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, MT 59840, USA. Y1 - 2008/06/27/ PY - 2008 DA - 2008 Jun 27 SP - 339 EP - 344 VL - 371 IS - 2 KW - Bacterial Proteins KW - 0 KW - Phosphoproteins KW - src-Family Kinases KW - EC 2.7.10.2 KW - Index Medicus KW - Phosphorylation KW - HeLa Cells KW - Humans KW - Point Mutation KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Bacterial Proteins -- genetics KW - Phosphoproteins -- genetics KW - Chlamydia trachomatis -- metabolism KW - src-Family Kinases -- metabolism KW - Bacterial Proteins -- metabolism KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70737188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Chlamydia+trachomatis+tarp+is+phosphorylated+by+src+family+tyrosine+kinases.&rft.au=Jewett%2C+Travis+J%3BDooley%2C+Cheryl+A%3BMead%2C+David+J%3BHackstadt%2C+Ted&rft.aulast=Jewett&rft.aufirst=Travis&rft.date=2008-06-27&rft.volume=371&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=1090-2104&rft_id=info:doi/10.1016%2Fj.bbrc.2008.04.089 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Cell Biol. 2004 Jan;14(1):36-44 [14729179] Infect Immun. 2002 Jul;70(7):3793-803 [12065523] Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10166-71 [15199184] Mol Biol Cell. 2004 Aug;15(8):3520-9 [15155808] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Microbiol Rev. 1991 Mar;55(1):143-90 [2030670] EMBO J. 1999 May 4;18(9):2459-71 [10228160] Infect Immun. 2005 Jul;73(7):3860-8 [15972471] Trends Microbiol. 2005 Oct;13(10):476-84 [16099656] Infect Immun. 2005 Oct;73(10):6407-18 [16177312] Cell Microbiol. 2005 Dec;7(12):1714-22 [16309458] Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15599-604 [17028176] Oncogene. 2007 May 24;26(24):3462-72 [17160020] PLoS Pathog. 2008 Mar;4(3):e1000021 [18369471] PLoS Pathog. 2008 Mar;4(3):e1000014 [18383626] Biochem J. 2003 Apr 1;371(Pt 1):199-204 [12534346] J Biol Chem. 2002 Mar 1;277(9):6775-8 [11788577] Mol Microbiol. 2002 Feb;43(4):971-80 [11929545] Traffic. 2004 Jun;5(6):418-25 [15117316] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbrc.2008.04.089 ER - TY - JOUR T1 - Comparison of the structural features of botulinum neurotoxin and NTNH, a non-toxic accessory protein of the progenitor complex AN - 19889797; 8420754 AB - The non-toxic, non-hemagglutinin (NTNH) protein occurs with the seven progenitor serotypes of the botulinum neurotoxins (BoNTs). Bioinformatic techniques predict that the N- and C-termini of NTNH have the same folds as the corresponding domains of BoNT. In contrast, the sequence pattern for zinc-binding in the catalytic domain of BoNT is absent in NTNH. The intermediate domain of NTNH is predicted to have neither the coiled-coil nor the hydrophobic characteristics of the corresponding region of BoNT. BoNT and NTNH are hypothesised to have diverged in their amino acid sequences from a common ancestor which accounts for their structural and functional differences. [Received 24 October 2007; Accepted 21 November 2007] JF - The Botulinum Journal AU - Krebs, Kristine M AU - Lebeda, Frank J AD - Advanced Academic Program in Biotechnology, Johns Hopkins University, Baltimore, MD 21218, USA; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/06/25/ PY - 2008 DA - 2008 Jun 25 SP - 116 EP - 134 PB - Inderscience Publishers Ltd., PO Box 735 VL - 1 IS - 1 SN - 1754-7318, 1754-7318 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - TECHNICAL JOURNALS KW - HEALTHCARE AND LEISURE JOURNALS KW - Biosciences and Bioinformatics KW - Healthcare and Medical Engineering KW - Stem cells KW - Serotypes KW - Structure-function relationships KW - Hydrophobicity KW - Botulinum toxin KW - Bioinformatics KW - J 02330:Biochemistry KW - A 01310:Products of Microorganisms KW - X 24490:Other KW - N3 11150:General and miscellaneous topics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19889797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Botulinum+Journal&rft.atitle=Comparison+of+the+structural+features+of+botulinum+neurotoxin+and+NTNH%2C+a+non-toxic+accessory+protein+of+the+progenitor+complex&rft.au=Krebs%2C+Kristine+M%3BLebeda%2C+Frank+J&rft.aulast=Krebs&rft.aufirst=Kristine&rft.date=2008-06-25&rft.volume=1&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=The+Botulinum+Journal&rft.issn=17547318&rft_id=info:doi/10.1504%2FTBJ.2008.018954 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Stem cells; Serotypes; Structure-function relationships; Hydrophobicity; Bioinformatics; Botulinum toxin DO - http://dx.doi.org/10.1504/TBJ.2008.018954 ER - TY - CPAPER T1 - STAT3 Mutations in Jobs Syndrome T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40970678; 4865222 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Paulson, Michelle AU - Elloumi, Houda AU - Holland, Steven Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Mutation KW - Stat3 protein KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40970678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=STAT3+Mutations+in+Jobs+Syndrome&rft.au=Paulson%2C+Michelle%3BElloumi%2C+Houda%3BHolland%2C+Steven&rft.aulast=Paulson&rft.aufirst=Michelle&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SOCS-1 and SOCS-3 are Induced Early in Response to Mycobacteria and Decrease Innate Immunity In Vitro T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40970649; 4865217 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Sampaio, Elizabeth Pereira AU - Zelazny, Adrian AU - Shea, Yvonne AU - Root, Jeremy AU - Paulson, Michele AU - Elloumi, Houda AU - Olivier, Ken AU - Holland, Steven Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40970649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=SOCS-1+and+SOCS-3+are+Induced+Early+in+Response+to+Mycobacteria+and+Decrease+Innate+Immunity+In+Vitro&rft.au=Sampaio%2C+Elizabeth+Pereira%3BZelazny%2C+Adrian%3BShea%2C+Yvonne%3BRoot%2C+Jeremy%3BPaulson%2C+Michele%3BElloumi%2C+Houda%3BOlivier%2C+Ken%3BHolland%2C+Steven&rft.aulast=Sampaio&rft.aufirst=Elizabeth&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - (1->3)-b-D-Glucan in Cereobrospinal Fluid is a Surrogate Marker for Detection and Therapeutic Response of Hematogenous Candida Meningoencephalitis T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40969202; 4865335 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Petraitiene, Ruta AU - Petraitis, Vidmantas AU - Hope, William AU - Mickiene, Diana AU - Kelaher, Amy AU - Murray, Heidi AU - Mya-San, Christine AU - Hughes, Johanna AU - Cotton, Margaret AU - Bacher, John AU - Bemjamin, Danny AU - Walsh, Thomas Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Meningoencephalitis KW - Candida UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40969202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=%281-%26gt%3B3%29-b-D-Glucan+in+Cereobrospinal+Fluid+is+a+Surrogate+Marker+for+Detection+and+Therapeutic+Response+of+Hematogenous+Candida+Meningoencephalitis&rft.au=Petraitiene%2C+Ruta%3BPetraitis%2C+Vidmantas%3BHope%2C+William%3BMickiene%2C+Diana%3BKelaher%2C+Amy%3BMurray%2C+Heidi%3BMya-San%2C+Christine%3BHughes%2C+Johanna%3BCotton%2C+Margaret%3BBacher%2C+John%3BBemjamin%2C+Danny%3BWalsh%2C+Thomas&rft.aulast=Petraitiene&rft.aufirst=Ruta&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Species-Dependent Differences in Virulence of Medically Important Zygomycetes in Neutropenic Hosts are Related to Sporangiospore Germination, Hyphal Metabolism, and Circulating Molecular Biomarker Levels T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40967339; 4865336 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Petraitiene, Ruta AU - Petraitis, Vidmantas AU - Antachopoulos, Charalampos AU - Hughes, Johanna E AU - Cotton, Margaret P AU - Harrington, Susan M AU - Kasai, Miki AU - Francesconi, Andrea AU - Beveridge, Mara G AU - Sein, Tin AU - Schaufele, Robert L AU - Bacher, John AU - Kontoyiannis, Dimitrios P AU - Walsh, Thomas J Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Bioindicators KW - Germination KW - Metabolism KW - Virulence KW - Sporangiospores KW - Biomarkers KW - Neutropenia KW - Zygomycetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40967339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=Species-Dependent+Differences+in+Virulence+of+Medically+Important+Zygomycetes+in+Neutropenic+Hosts+are+Related+to+Sporangiospore+Germination%2C+Hyphal+Metabolism%2C+and+Circulating+Molecular+Biomarker+Levels&rft.au=Petraitiene%2C+Ruta%3BPetraitis%2C+Vidmantas%3BAntachopoulos%2C+Charalampos%3BHughes%2C+Johanna+E%3BCotton%2C+Margaret+P%3BHarrington%2C+Susan+M%3BKasai%2C+Miki%3BFrancesconi%2C+Andrea%3BBeveridge%2C+Mara+G%3BSein%2C+Tin%3BSchaufele%2C+Robert+L%3BBacher%2C+John%3BKontoyiannis%2C+Dimitrios+P%3BWalsh%2C+Thomas+J&rft.aulast=Petraitiene&rft.aufirst=Ruta&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Idiopathic CD4+ Lymphocytopenia: Natural History and Prognostic Factors T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40966988; 4865227 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Zonios, Dimitrios AU - Falloon, Judith AU - Bennett, John AU - Shaw, Pamela AU - Chaitt, Doreen AU - Polis, Michael AU - Kovacs, Joseph AU - Davey, Richard AU - Lane, H Clifford AU - Masur, Henry AU - Sereti, Irini Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Historical account KW - CD4 antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40966988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=Idiopathic+CD4%2B+Lymphocytopenia%3A+Natural+History+and+Prognostic+Factors&rft.au=Zonios%2C+Dimitrios%3BFalloon%2C+Judith%3BBennett%2C+John%3BShaw%2C+Pamela%3BChaitt%2C+Doreen%3BPolis%2C+Michael%3BKovacs%2C+Joseph%3BDavey%2C+Richard%3BLane%2C+H+Clifford%3BMasur%2C+Henry%3BSereti%2C+Irini&rft.aulast=Zonios&rft.aufirst=Dimitrios&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Autosomal-dominant Late-onset Immunodeficiency with Susceptibility to Mycobacteria, Fungi, Papillomavirus and Myeloid Malignancies T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40965401; 4865226 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Vinh, Donald AU - Patel, Smita AU - Uzel, Gulbu AU - Anderson, Victoria AU - Freeman, Alexandra AU - Olivier, Kenneth AU - Elloumi, Houda AU - Ding, Li AU - Kuhns, Douglas AU - Fink, Danielle AU - Long-Priel, Deborah AU - DeLeo, Frank AU - Sampaio, Elizabeth AU - Paulson, Michelle AU - Hsu, Amy AU - Zelazny, Adrian AU - Root, Jeremy AU - Frucht, David AU - Holland, Steven Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Fungi KW - Malignancy KW - Immunodeficiency KW - Papillomavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40965401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=A+Novel+Autosomal-dominant+Late-onset+Immunodeficiency+with+Susceptibility+to+Mycobacteria%2C+Fungi%2C+Papillomavirus+and+Myeloid+Malignancies&rft.au=Vinh%2C+Donald%3BPatel%2C+Smita%3BUzel%2C+Gulbu%3BAnderson%2C+Victoria%3BFreeman%2C+Alexandra%3BOlivier%2C+Kenneth%3BElloumi%2C+Houda%3BDing%2C+Li%3BKuhns%2C+Douglas%3BFink%2C+Danielle%3BLong-Priel%2C+Deborah%3BDeLeo%2C+Frank%3BSampaio%2C+Elizabeth%3BPaulson%2C+Michelle%3BHsu%2C+Amy%3BZelazny%2C+Adrian%3BRoot%2C+Jeremy%3BFrucht%2C+David%3BHolland%2C+Steven&rft.aulast=Vinh&rft.aufirst=Donald&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of Central Venous Catheter Management on Outcome in Cancer Patients with Candidemia who Survived more than 72 Hours after the First Positive Blood Culture T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40964984; 4865282 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Velasco, Eduardo AU - Portugal, Rodrigo Doyle Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Cancer KW - Medical instruments KW - Candidemia KW - Blood culture KW - Catheters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=Influence+of+Central+Venous+Catheter+Management+on+Outcome+in+Cancer+Patients+with+Candidemia+who+Survived+more+than+72+Hours+after+the+First+Positive+Blood+Culture&rft.au=Velasco%2C+Eduardo%3BPortugal%2C+Rodrigo+Doyle&rft.aulast=Velasco&rft.aufirst=Eduardo&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Herniated Nuclear Morphology and Cytoskeletal Anomalies in Neutrophils from Sisters with Recurrent Infections T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40963950; 4865225 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Vinh, Donald AU - Uzel, Gulbu AU - Gallin, John AU - Holland, Steven Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Infection KW - Morphology KW - Cytoskeleton KW - Recurrent infection KW - Leukocytes (neutrophilic) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40963950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=Herniated+Nuclear+Morphology+and+Cytoskeletal+Anomalies+in+Neutrophils+from+Sisters+with+Recurrent+Infections&rft.au=Vinh%2C+Donald%3BUzel%2C+Gulbu%3BGallin%2C+John%3BHolland%2C+Steven&rft.aulast=Vinh&rft.aufirst=Donald&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The First Report of Somatic Mutation Reversion X-Linked Chronic Granulomatous Disease T2 - 15th International Symposium on Infections in the Immunocompromised Host AN - 40962533; 4865223 JF - 15th International Symposium on Infections in the Immunocompromised Host AU - Uzel, Gulbu AU - Kuhns, Douglas AU - Linton, Gilda AU - Quie, Paul AU - Holland, Steven Y1 - 2008/06/22/ PY - 2008 DA - 2008 Jun 22 KW - Mutation KW - Reversion KW - Chronic granulomatous disease KW - X chromosome KW - New records UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40962533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.atitle=The+First+Report+of+Somatic+Mutation+Reversion+X-Linked+Chronic+Granulomatous+Disease&rft.au=Uzel%2C+Gulbu%3BKuhns%2C+Douglas%3BLinton%2C+Gilda%3BQuie%2C+Paul%3BHolland%2C+Steven&rft.aulast=Uzel&rft.aufirst=Gulbu&rft.date=2008-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+International+Symposium+on+Infections+in+the+Immunocompromised+Host&rft.issn=&rft_id=info:doi/ L2 - http://www.ichs.org/Greece2008/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Spatial distribution of VEGF isoforms and chemotactic signals in the vicinity of a tumor AN - 20786405; 8259554 AB - We propose a mathematical model that describes the formation of gradients of different isoforms of vascular endothelial growth factor (VEGF). VEGF is crucial in the process of tumor-induced angiogenesis, and recent experiments strongly suggest that the molecule is most potent when bound to the extracellular matrix (ECM). Using a system of reaction-diffusion equations, we study diffusion of VEGF, binding of VEGF to the ECM, and cleavage of VEGF from the ECM by matrix metalloproteases (MMPs). We find that spontaneous gradients of matrix-bound VEGF are possible for an isoform that binds weakly to the ECM (i.e. VEGF sub(1) sub(6) sub(5)), but cleavage by MMPs is required to form long-range gradients of isoforms that bind rapidly to the ECM (i.e. VEGF sub(1) sub(8) sub(9)). We also find that gradient strengths and ranges are regulated by MMPs. Finally, we find that VEGF molecules cleaved from the ECM may be distributed in patterns that are not conducive to chemotactic migration toward a tumor, depending on the spatial distribution of MMP molecules. Our model elegantly explains a number of in vivo observations concerning the significance of different VEGF isoforms, points to VEGF sub(1) sub(6) sub(5) as an especially significant therapeutic target and indicator of a tumor's angiogenic potential, and enables predictions that are subject to testing with in vitro experiments. JF - Journal of Theoretical Biology AU - Small, A R AU - Neagu, A AU - Amyot, F AU - Sackett, D AU - Chernomordik, V AU - Gandjbakhche, A AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA, alex_small2002@yahoo.com Y1 - 2008/06/21/ PY - 2008 DA - 2008 Jun 21 SP - 593 EP - 607 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 252 IS - 4 SN - 0022-5193, 0022-5193 KW - Ecology Abstracts KW - Vascular endothelial growth factor KW - Mathematical models KW - Spatial distribution KW - Extracellular matrix KW - Angiogenesis KW - Diffusion KW - Tumors KW - Chemotaxis KW - D 04030:Models, Methods, Remote Sensing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20786405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Theoretical+Biology&rft.atitle=Spatial+distribution+of+VEGF+isoforms+and+chemotactic+signals+in+the+vicinity+of+a+tumor&rft.au=Small%2C+A+R%3BNeagu%2C+A%3BAmyot%2C+F%3BSackett%2C+D%3BChernomordik%2C+V%3BGandjbakhche%2C+A&rft.aulast=Small&rft.aufirst=A&rft.date=2008-06-21&rft.volume=252&rft.issue=4&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Journal+of+Theoretical+Biology&rft.issn=00225193&rft_id=info:doi/10.1016%2Fj.jtbi.2008.02.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Mathematical models; Spatial distribution; Extracellular matrix; Angiogenesis; Diffusion; Tumors; Chemotaxis DO - http://dx.doi.org/10.1016/j.jtbi.2008.02.009 ER - TY - JOUR T1 - Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants. AN - 69327681; 18558008 AB - Some of the biochemical events that lead to necrosis of the liver are well-known. However, the pathogenesis of necrosis of the liver from exposure to hepatotoxicants is a complex biological response to the injury. We hypothesize that gene expression profiles can serve as a signature to predict the level of necrosis elicited by acute exposure of rats to a variety of hepatotoxicants and postulate that the expression profiles of the predictor genes in the signature can provide insight to some of the biological processes and molecular pathways that may be involved in the manifestation of necrosis of the rat liver. Rats were treated individually with one of seven known hepatotoxicants and were analyzed for gene expression by microarray. Liver samples were grouped by the level of necrosis exhibited in the tissue. Analysis of significantly differentially expressed genes between adjacent necrosis levels revealed that inflammation follows programmed cell death in response to the agents. Using a Random Forest classifier with feature selection, 21 informative genes were identified which achieved 90%, 80% and 60% prediction accuracies of necrosis against independent test data derived from the livers of rats exposed to acetaminophen, carbon tetrachloride, and allyl alcohol, respectively. Pathway and gene network analyses of the genes in the signature revealed several gene interactions suggestive of apoptosis as a process possibly involved in the manifestation of necrosis of the liver from exposure to the hepatotoxicants. Cytotoxic effects of TNF-alpha, as well as transcriptional regulation by JUN and TP53, and apoptosis-related genes possibly lead to necrosis. The data analysis, gene selection and prediction approaches permitted grouping of the classes of rat liver samples exhibiting necrosis to improve the accuracy of predicting the level of necrosis as a phenotypic end-point observed from the exposure. The strategy, along with pathway analysis and gene network reconstruction, led to the identification of 1) expression profiles of genes as a signature of necrosis and 2) perturbed regulatory processes that exhibited biological relevance to the manifestation of necrosis from exposure of rat livers to the compendium of hepatotoxicants. JF - BMC genomics AU - Huang, Lingkang AU - Heinloth, Alexandra N AU - Zeng, Zhao-Bang AU - Paules, Richard S AU - Bushel, Pierre R AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. lingkang.huang@gmail.com Y1 - 2008/06/16/ PY - 2008 DA - 2008 Jun 16 SP - 288 VL - 9 KW - Poisons KW - 0 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Reproducibility of Results KW - Oligonucleotide Array Sequence Analysis KW - Principal Component Analysis KW - Gene Regulatory Networks KW - Inflammation -- chemically induced KW - Bayes Theorem KW - Predictive Value of Tests KW - Models, Biological KW - Rats KW - Phenotype KW - Gene Expression Profiling KW - Cell Death -- genetics KW - Inflammation -- pathology KW - Liver -- pathology KW - Apoptosis -- genetics KW - Poisons -- toxicity KW - Liver -- drug effects KW - Necrosis -- pathology KW - Necrosis -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69327681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Genes+related+to+apoptosis+predict+necrosis+of+the+liver+as+a+phenotype+observed+in+rats+exposed+to+a+compendium+of+hepatotoxicants.&rft.au=Huang%2C+Lingkang%3BHeinloth%2C+Alexandra+N%3BZeng%2C+Zhao-Bang%3BPaules%2C+Richard+S%3BBushel%2C+Pierre+R&rft.aulast=Huang&rft.aufirst=Lingkang&rft.date=2008-06-16&rft.volume=9&rft.issue=&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2F1471-2164-9-288 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-19 N1 - Date created - 2008-07-22 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE5595; GEO N1 - SuppNotes - Cited By: AAPS J. 2006;8(1):E48-54 [16584133] J Pharmacol Exp Ther. 2006 Aug;318(2):792-802 [16687475] Toxicol Pathol. 2006;34(7):921-8 [17178692] J Hepatol. 2007 Feb;46(2):230-8 [17125873] Cancer Biomark. 2005;1(1):29-39 [17192030] Mol Pharmacol. 2001 Nov;60(5):907-15 [11641418] Toxicol Pathol. 2002 Jan-Feb;30(1):88-92 [11890481] Pac Symp Biocomput. 2002;:437-49 [11928497] Biochem Pharmacol. 2002 Aug 1;64(3):413-24 [12147292] Nat Genet. 2002 Dec;32 Suppl:522-5 [12454648] Crit Rev Toxicol. 2003;33(2):105-36 [12708612] Toxicology. 2003 Aug 28;190(3):155-69 [12927372] Toxicol Appl Pharmacol. 2003 Sep 1;191(2):118-29 [12946648] Hepatology. 2003 Nov;38(5):1188-98 [14578857] J Cell Biochem. 2003 Nov 1;90(4):837-55 [14587038] Liver Int. 2004 Apr;24(2):85-9 [15078470] J Pharmacol Exp Ther. 2004 Jun;309(3):978-86 [14978197] Nature. 2004 Aug 12;430(7001):743-7 [15269782] Science. 1995 Oct 20;270(5235):467-70 [7569999] Toxicol Pathol. 1996 Mar-Apr;24(2):181-9 [8992608] Kidney Int. 1999 Jun;55(6):2322-37 [10354280] Bioinformatics. 2004 Nov 22;20(17):3246-8 [15180930] Int J Med Inform. 2005 Aug;74(7-8):491-503 [15967710] BMC Bioinformatics. 2005;6:168 [15998470] BMC Bioinformatics. 2006;7:3 [16398926] Cell Mol Immunol. 2007 Feb;4(1):43-52 [17349210] Toxicol Pathol. 2007 Feb;35(2):276-83 [17366322] BMC Syst Biol. 2007;1:15 [17408499] Genome Inform. 2006;17(2):77-88 [17503381] Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18211-6 [17984051] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2164-9-288 ER - TY - JOUR T1 - Olfactory pathogenesis of idiopathic Parkinson disease revisited. AN - 742780888; pmid-18442121 AB - Idiopathic Parkinson disease (PD) is traditionally considered a movement disorder with hallmark lesions located in the substantia nigra pars compacta (SNpc). However, recent histopathological studies of some PD cases suggest the possibility of a multisystem disorder which progresses in a predictable sequence as described in Braak's staging criteria. The disease process starts in the dorsal motor nucleus of the vagus (dmX) and anterior olfactory nucleus and bulb, and from there, spreads through the brainstem nuclei to ultimately reach the SNpc, which then presents as symptomatic PD. In this article, we would like to revisit the olfactory pathogenesis of PD based on Braak's staging system and review anatomical pathways supporting such a possibility. We also suggest some biomarkers for early stages of PD. Additionally, we present and discuss the possibility that a prion-like process underlies the neurodegenerative changes in PD. (c) 2008 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Lerner, Alicja AU - Bagic, Anto AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. lernera@mail.nih.gov Y1 - 2008/06/15/ PY - 2008 DA - 2008 Jun 15 SP - 1076 EP - 1084 VL - 23 IS - 8 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - alpha-Synuclein -- metabolism KW - Humans KW - Vagus Nerve Diseases -- pathology KW - Vagus Nerve -- pathology KW - Neural Pathways -- pathology KW - Lewy Bodies -- pathology KW - Parkinson Disease -- pathology KW - Alzheimer Disease -- diagnosis KW - Neurons -- pathology KW - Parkinson Disease -- diagnosis KW - Amyloid beta-Protein -- metabolism KW - Vagus Nerve Diseases -- diagnosis KW - Cerebral Cortex -- pathology KW - Nerve Degeneration -- pathology KW - Limbic System -- pathology KW - Prion Diseases -- pathology KW - Nerve Degeneration -- diagnosis KW - Prion Diseases -- diagnosis KW - Alzheimer Disease -- pathology KW - Olfactory Bulb -- pathology KW - Substantia Nigra -- pathology KW - Olfactory Nerve -- pathology KW - Brain Stem -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742780888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Olfactory+pathogenesis+of+idiopathic+Parkinson+disease+revisited.&rft.au=Lerner%2C+Alicja%3BBagic%2C+Anto&rft.aulast=Lerner&rft.aufirst=Alicja&rft.date=2008-06-15&rft.volume=23&rft.issue=8&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - SuppNotes - Comment In: Mov Disord. 2010 Jan 15;25(1):122-3[18823028] N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Designing phase 0 cancer clinical trials. AN - 69227086; 18559582 AB - Phase 0 trials are designed primarily to evaluate the pharmacodynamic and/or pharmacokinetic properties of selected investigational agents before initiating more traditional phase I testing. One of the major objectives of phase 0 trials is to interrogate and refine a target or biomarker assay for drug effect in human samples implementing procedures developed and validated in preclinical models. Thus, close collaboration between laboratory scientists and clinical investigators is essential to the design and conduct of phase 0 trials. Given the relatively small number of patients and tissue samples, showing a significant drug effect in phase 0 trials requires precise and reproducible assay procedures and innovative statistical methodology. Furthermore, phase 0 trials involving limited exposure of a study agent administered at low doses and/or for a short period allow them to be initiated under the Food and Drug Administration exploratory investigational new drug guidance with less preclinical toxicity data than usually required for traditional first-in-human studies. Because of the very limited drug exposure, phase 0 trials offer no chance of therapeutic benefit, which can impede patient enrollment, particularly if invasive tumor biopsies are required. The challenges to accrual are not insurmountable, however, and well-designed and executed phase 0 trials are feasible and have great potential for improving the efficiency and success of subsequent trials, particularly those evaluating molecularly targeted agents. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Murgo, Anthony J AU - Kummar, Shivaani AU - Rubinstein, Larry AU - Gutierrez, Martin AU - Collins, Jerry AU - Kinders, Robert AU - Parchment, Ralph E AU - Ji, Jiuping AU - Steinberg, Seth M AU - Yang, Sherry X AU - Hollingshead, Melinda AU - Chen, Alice AU - Helman, Lee AU - Wiltrout, Robert AU - Tomaszewski, Joseph E AU - Doroshow, James H AD - Division of Cancer Treatment and Diagnosis and Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-2440, USA. murgoa@mail.nih.gov Y1 - 2008/06/15/ PY - 2008 DA - 2008 Jun 15 SP - 3675 EP - 3682 VL - 14 IS - 12 SN - 1078-0432, 1078-0432 KW - Index Medicus KW - Humans KW - Algorithms KW - Drug Screening Assays, Antitumor -- methods KW - Models, Biological KW - Research Design KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69227086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Designing+phase+0+cancer+clinical+trials.&rft.au=Murgo%2C+Anthony+J%3BKummar%2C+Shivaani%3BRubinstein%2C+Larry%3BGutierrez%2C+Martin%3BCollins%2C+Jerry%3BKinders%2C+Robert%3BParchment%2C+Ralph+E%3BJi%2C+Jiuping%3BSteinberg%2C+Seth+M%3BYang%2C+Sherry+X%3BHollingshead%2C+Melinda%3BChen%2C+Alice%3BHelman%2C+Lee%3BWiltrout%2C+Robert%3BTomaszewski%2C+Joseph+E%3BDoroshow%2C+James+H&rft.aulast=Murgo&rft.aufirst=Anthony&rft.date=2008-06-15&rft.volume=14&rft.issue=12&rft.spage=3675&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4560 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-06-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Drug Discov. 2004 Aug;3(8):711-5 [15286737] J Clin Oncol. 2004 Sep 1;22(17):3593-607 [15337810] J Clin Oncol. 2005 Aug 20;23(24):5417-9 [16027435] Clin Cancer Res. 2005 Nov 15;11(22):7967-85 [16299226] Nat Rev Cancer. 2007 Feb;7(2):131-9 [17251919] Br J Cancer. 2001 May 18;84(10):1424-31 [11355958] Mol Interv. 2007 Dec;7(6):325-34 [18199854] Clin Pharmacol Ther. 2008 Feb;83(2):358-60 [18091759] Clin Cancer Res. 2008 Jun 15;14(12):3664-9 [18559580] Clin Cancer Res. 2008 Jun 15;14(12):3683-8 [18559583] Clin Cancer Res. 2007 Feb 1;13(3):783-4 [17289866] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4560 ER - TY - JOUR T1 - Oncologic phase 0 trials incorporating clinical pharmacodynamics: from concept to patient. AN - 69224826; 18559579 AB - The U.S. Food and Drug Administration recently issued an Exploratory Investigational New Drug (IND) guidance that provides a platform for the evaluation of targeted anticancer agents in small, early-phase human clinical trials that can be used to establish the feasibility of proof-of-principle target modulation assays, as well as the preliminary pharmacokinetics and molecular imaging potential of new anticancer molecules. The exploratory IND allows for reduced requirements for manufacturing and toxicologic assessment. Early clinical trials done in this fashion have no therapeutic intent. In this series of articles in CCR Focus, the development of this new IND mechanism, its effect on clinical trial design and clinical pharmacodynamics, the ethical implications of nontherapeutic clinical investigations, and the perspective of the pharmaceutical industry on this approach are examined. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Doroshow, James H AU - Parchment, Ralph E AD - Division of Cancer Treatment and Diagnosis, and the Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. doroshoj@mail.nih.gov Y1 - 2008/06/15/ PY - 2008 DA - 2008 Jun 15 SP - 3658 EP - 3663 VL - 14 IS - 12 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Concept Formation KW - Clinical Laboratory Techniques -- standards KW - Humans KW - Drug Delivery Systems -- methods KW - Specimen Handling -- methods KW - Antineoplastic Agents -- pharmacokinetics KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69224826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Oncologic+phase+0+trials+incorporating+clinical+pharmacodynamics%3A+from+concept+to+patient.&rft.au=Doroshow%2C+James+H%3BParchment%2C+Ralph+E&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2008-06-15&rft.volume=14&rft.issue=12&rft.spage=3658&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4562 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-06-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2001 May 18;84(10):1424-31 [11355958] Clin Cancer Res. 2008 Jun 15;14(12):3692-7 [18559585] Clin Cancer Res. 2004 Jun 1;10(11):3885-96 [15173098] J Natl Cancer Inst. 2004 Jul 7;96(13):990-7 [15240782] Nat Rev Drug Discov. 2004 Aug;3(8):711-5 [15286737] Biometrics. 1990 Mar;46(1):33-48 [2350571] J Natl Cancer Inst. 1997 Aug 6;89(15):1138-47 [9262252] Clin Cancer Res. 2005 Jun 15;11(12):4338-40 [15958615] J Natl Cancer Inst. 2006 May 3;98(9):580-98 [16670384] Br J Clin Pharmacol. 2006 Jul;62(1):15-26 [16842375] Nat Rev Cancer. 2007 Feb;7(2):131-9 [17251919] Clin Cancer Res. 2007 Feb 1;13(3):783-4 [17289866] Clin Cancer Res. 2007 Jul 15;13(14):4033-4 [17634525] Br J Cancer. 2007 Sep 3;97(5):577-81 [17726450] Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6719-26 [18006773] J Law Med Ethics. 2007 Winter;35(4):727-33, 514 [18076522] Clin Pharmacol Ther. 2008 Feb;83(2):358-60 [18091759] Clin Cancer Res. 2008 Jun 15;14(12):3664-9 [18559580] Clin Cancer Res. 2008 Jun 15;14(12):3675-82 [18559582] Clin Cancer Res. 2008 Jun 15;14(12):3683-8 [18559583] Clin Cancer Res. 2008 Jun 15;14(12):3689-91 [18559584] Nat Biotechnol. 2003 Jul;21(7):722-3 [12833079] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4562 ER - TY - JOUR T1 - The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. AN - 71678086; 18397888 AB - Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and apparently sporadic Parkinson disease. LRRK2 is a multidomain protein kinase with autophosphorylation activity. It has previously been shown that the kinase activity of LRRK2 is required for neuronal toxicity, suggesting that understanding the mechanism of kinase activation and regulation may be important for the development of specific kinase inhibitors for Parkinson disease treatment. Here, we show that LRRK2 predominantly exists as a dimer under native conditions, a state that appears to be stabilized by multiple domain-domain interactions. Furthermore, an intact C terminus, but not N terminus, is required for autophosphorylation activity. We identify two residues in the activation loop that contribute to the regulation of LRRK2 autophosphorylation. Finally, we demonstrate that LRRK2 undergoes intramolecular autophosphorylation. Together, these results provide insight into the mechanism and regulation of LRRK2 kinase activity. JF - The Journal of biological chemistry AU - Greggio, Elisa AU - Zambrano, Ibardo AU - Kaganovich, Alice AU - Beilina, Alexandra AU - Taymans, Jean-Marc AU - Daniëls, Veronique AU - Lewis, Patrick AU - Jain, Shushant AU - Ding, Jinhui AU - Syed, Ali AU - Thomas, Kelly J AU - Baekelandt, Veerle AU - Cookson, Mark R AD - Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, NIA, National Institutes of Health, Bethesda, MD 20892, USA. greggio@mail.nih.gov Y1 - 2008/06/13/ PY - 2008 DA - 2008 Jun 13 SP - 16906 EP - 16914 VL - 283 IS - 24 SN - 0021-9258, 0021-9258 KW - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 KW - EC 2.7.11.1 KW - Lrrk2 protein, mouse KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Animals KW - COS Cells KW - Humans KW - Dimerization KW - Two-Hybrid System Techniques KW - Cercopithecus aethiops KW - Brain -- metabolism KW - Protein Structure, Tertiary KW - Protein Binding KW - Models, Biological KW - Protein Conformation KW - Protein-Serine-Threonine Kinases -- chemistry KW - Phosphorylation KW - Parkinson Disease -- metabolism KW - Gene Expression Regulation KW - Protein-Serine-Threonine Kinases -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71678086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+Parkinson+disease-associated+leucine-rich+repeat+kinase+2+%28LRRK2%29+is+a+dimer+that+undergoes+intramolecular+autophosphorylation.&rft.au=Greggio%2C+Elisa%3BZambrano%2C+Ibardo%3BKaganovich%2C+Alice%3BBeilina%2C+Alexandra%3BTaymans%2C+Jean-Marc%3BDani%C3%ABls%2C+Veronique%3BLewis%2C+Patrick%3BJain%2C+Shushant%3BDing%2C+Jinhui%3BSyed%2C+Ali%3BThomas%2C+Kelly+J%3BBaekelandt%2C+Veerle%3BCookson%2C+Mark+R&rft.aulast=Greggio&rft.aufirst=Elisa&rft.date=2008-06-13&rft.volume=283&rft.issue=24&rft.spage=16906&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M708718200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-06-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Parkinsonism Relat Disord. 2007 Oct;13(7):382-5 [17400507] Exp Cell Res. 2007 Oct 1;313(16):3658-70 [17706965] J Biol Chem. 2001 Jan 19;276(3):1961-7 [11053428] Ann Neurol. 2002 Mar;51(3):296-301 [11891824] Proc Natl Acad Sci U S A. 2002 May 28;99(11):7432-7 [12032300] J Biol Chem. 2003 Nov 21;278(47):47245-52 [12968034] Mol Cell. 2004 Sep 10;15(5):661-75 [15350212] Nucleic Acids Res. 1997 Dec 15;25(24):4876-82 [9396791] Neuron. 2004 Nov 18;44(4):595-600 [15541308] Neuron. 2004 Nov 18;44(4):601-7 [15541309] Nat Struct Mol Biol. 2004 Dec;11(12):1192-7 [15543157] J Biol Chem. 2005 Apr 8;280(14):13477-82 [15695508] Ann Neurol. 2005 Jun;57(6):918-21 [15880653] Mov Disord. 2005 Dec;20(12):1653-5 [16149095] Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16842-7 [16269541] Proteins. 2005;61 Suppl 7:152-6 [16187357] Hum Mol Genet. 2006 Jan 15;15(2):223-32 [16321986] N Engl J Med. 2006 Jan 26;354(4):422-3 [16436781] N Engl J Med. 2006 Jan 26;354(4):424-5 [16436782] Cell Signal. 2006 Jun;18(6):910-20 [16243488] Neurobiol Dis. 2006 Aug;23(2):329-41 [16750377] Nat Neurosci. 2006 Oct;9(10):1231-3 [16980962] J Neural Transm Suppl. 2006;(70):221-9 [17017533] Curr Opin Struct Biol. 2006 Dec;16(6):686-92 [17085044] Hum Mol Genet. 2007 Jan 15;16(2):223-32 [17200152] Biochemistry. 2007 Feb 6;46(5):1380-8 [17260967] Biochem Biophys Res Commun. 2007 Jun 8;357(3):668-71 [17442267] J Neurochem. 2007 Jul;102(1):93-102 [17394548] Biochem J. 2007 Jul 15;405(2):307-17 [17447891] Neuroscience. 2007 Jul 29;147(4):1047-58 [17611037] Hum Mol Genet. 2007 Sep 1;16(17):2031-9 [17584768] Neurochem Res. 2007 Oct;32(10):1700-8 [17440812] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1499-504 [18230735] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M708718200 ER - TY - CPAPER T1 - Reliability and Validity of Measurements with the Impedimed@@uRG@ Bioelectrical Spectroscopy Unit as Referenced to the Opto-Electrical Perometer@@uRG@ T2 - 2008 Annual Conference and Exposition of the American Physical Therapy Association (PT 2008) AN - 40955408; 4869830 JF - 2008 Annual Conference and Exposition of the American Physical Therapy Association (PT 2008) AU - Jain, Mina AU - Danoff, Jerome Y1 - 2008/06/11/ PY - 2008 DA - 2008 Jun 11 KW - Spectroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40955408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Conference+and+Exposition+of+the+American+Physical+Therapy+Association+%28PT+2008%29&rft.atitle=Reliability+and+Validity+of+Measurements+with+the+Impedimed%40%40uRG%40+Bioelectrical+Spectroscopy+Unit+as+Referenced+to+the+Opto-Electrical+Perometer%40%40uRG%40&rft.au=Jain%2C+Mina%3BDanoff%2C+Jerome&rft.aulast=Jain&rft.aufirst=Mina&rft.date=2008-06-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Conference+and+Exposition+of+the+American+Physical+Therapy+Association+%28PT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.apta.org/am/aptaapps/programming/pt/progindex.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification. AN - 69207650; 18440504 AB - Mitochondrial dysfunction plays a central role in the selective vulnerability of dopaminergic neurons in Parkinson's disease (PD) and is influenced by both environmental and genetic factors. Expression of the PD protein alpha-synuclein or its familial mutants often sensitizes neurons to oxidative stress and to damage by mitochondrial toxins. This effect is thought to be indirect, since little evidence physically linking alpha-synuclein to mitochondria has been reported. Here, we show that the distribution of alpha-synuclein within neuronal and non-neuronal cells is dependent on intracellular pH. Cytosolic acidification induces translocation of alpha-synuclein from the cytosol onto the surface of mitochondria. Translocation occurs rapidly under artificially-induced low pH conditions and as a result of pH changes during oxidative or metabolic stress. Binding is likely facilitated by low pH-induced exposure of the mitochondria-specific lipid cardiolipin. These results imply a direct role for alpha-synuclein in mitochondrial physiology, especially under pathological conditions, and in principle, link alpha-synuclein to other PD genes in regulating mitochondrial homeostasis. JF - Experimental cell research AU - Cole, Nelson B AU - Dieuliis, Diane AU - Leo, Paul AU - Mitchell, Drake C AU - Nussbaum, Robert L AD - Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. ncole@mail.nih.gov Y1 - 2008/06/10/ PY - 2008 DA - 2008 Jun 10 SP - 2076 EP - 2089 VL - 314 IS - 10 KW - Antimetabolites KW - 0 KW - Enzyme Inhibitors KW - Oxidants KW - Uncoupling Agents KW - alpha-Synuclein KW - Carbonyl Cyanide m-Chlorophenyl Hydrazone KW - 555-60-2 KW - Sodium Azide KW - 968JJ8C9DV KW - Deoxyglucose KW - 9G2MP84A8W KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Carbonyl Cyanide m-Chlorophenyl Hydrazone -- metabolism KW - Sodium Azide -- metabolism KW - Humans KW - Hydrogen Peroxide -- metabolism KW - Hydrogen-Ion Concentration KW - Protein Binding KW - Mitochondrial Membranes -- metabolism KW - Antimetabolites -- metabolism KW - Mitochondrial Membranes -- ultrastructure KW - Oxidative Stress KW - Uncoupling Agents -- metabolism KW - Enzyme Inhibitors -- metabolism KW - Oxidants -- metabolism KW - Cell Line KW - Protein Transport KW - Deoxyglucose -- metabolism KW - Mitochondria -- ultrastructure KW - alpha-Synuclein -- metabolism KW - Parkinson Disease -- metabolism KW - Mitochondria -- metabolism KW - alpha-Synuclein -- genetics KW - Parkinson Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69207650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Mitochondrial+translocation+of+alpha-synuclein+is+promoted+by+intracellular+acidification.&rft.au=Cole%2C+Nelson+B%3BDieuliis%2C+Diane%3BLeo%2C+Paul%3BMitchell%2C+Drake+C%3BNussbaum%2C+Robert+L&rft.aulast=Cole&rft.aufirst=Nelson&rft.date=2008-06-10&rft.volume=314&rft.issue=10&rft.spage=2076&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=1090-2422&rft_id=info:doi/10.1016%2Fj.yexcr.2008.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-23 N1 - Date created - 2008-06-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Annu Rev Pharmacol Toxicol. 2007;47:143-83 [17029566] Am J Physiol Cell Physiol. 2007 Jan;292(1):C33-44 [16899548] Curr Alzheimer Res. 2007 Feb;4(1):53-65 [17316166] J Neurochem. 2007 Mar;100(6):1469-79 [17241123] Neurobiol Aging. 2007 Nov;28(11):1709-17 [16978743] J Biol Chem. 2008 Apr 4;283(14):9089-100 [18245082] Cell Mol Life Sci. 2008 Apr;65(7-8):1272-84 [18322646] Apoptosis. 2006 Jul;11(7):1149-59 [16699952] Prog Lipid Res. 2000 May;39(3):257-88 [10799718] Am J Pathol. 2000 Aug;157(2):401-10 [10934145] J Neurosci Res. 2000 Dec 15;62(6):814-20 [11107166] J Neurochem. 2001 Feb;76(4):998-1009 [11181819] Hum Mol Genet. 2001 Apr 15;10(9):919-26 [11309365] J Biol Chem. 2002 Feb 22;277(8):6344-52 [11744721] J Neurophysiol. 2002 May;87(5):2209-24 [11976362] Cell Growth Differ. 2002 Sep;13(9):449-55 [12354754] Brain Pathol. 2002 Oct;12(4):499-510 [12408237] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4078-83 [12642658] J Biol Chem. 2003 Jul 4;278(27):25009-13 [12719433] J Neurochem. 2003 Sep;86(5):1297-307 [12911637] Exp Neurol. 2004 Apr;186(2):158-72 [15026254] Development. 2004 May;131(9):2183-94 [15073152] J Biol Chem. 2004 Apr 30;279(18):18614-22 [14985362] J Biol Chem. 2004 May 14;279(20):20699-707 [14742431] Science. 2004 May 21;304(5674):1158-60 [15087508] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9103-8 [15181200] Mol Biol Cell. 2004 Jul;15(7):3061-72 [15107464] J Neurosci. 2004 Jul 28;24(30):6715-23 [15282274] Cell Death Differ. 2004 Sep;11(9):953-61 [15195071] J Bioenerg Biomembr. 2004 Aug;36(4):375-9 [15377875] Anal Biochem. 1978 Oct 1;90(1):420-6 [727482] Biochemistry. 1979 May 29;18(11):2210-8 [36128] J Cell Biol. 1982 Apr;93(1):103-10 [7068748] Biochim Biophys Acta. 1985 Jun 12;822(1):1-42 [2408671] Circ Res. 1987 Feb;60(2):153-68 [3552284] Mol Cell Biol. 1987 May;7(5):1984-8 [3037340] J Clin Invest. 1989 Feb;83(2):386-96 [2536397] J Neurochem. 1990 Mar;54(3):823-7 [2154550] Eur J Biochem. 1994 Mar 15;220(3):871-9 [8143741] Circ Res. 1995 Jul;77(1):174-81 [7788875] J Histochem Cytochem. 1996 Dec;44(12):1481-8 [8985140] J Physiol. 1997 Jul 1;502 ( Pt 1):161-74 [9234204] Biophys J. 1998 Feb;74(2 Pt 1):879-91 [9533699] Ann Neurol. 1998 Sep;44(3 Suppl 1):S99-109 [9749580] Cancer Res. 2004 Nov 1;64(21):7867-78 [15520193] J Biol Chem. 2005 Mar 11;280(10):9678-90 [15615715] Pflugers Arch. 2004 Dec;449(3):307-18 [15452716] Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5215-20 [15784737] Proc Natl Acad Sci U S A. 2005 May 31;102(22):8024-9 [15911761] J Neurochem. 2005 Jun;93(6):1542-50 [15935070] Hum Mol Genet. 2005 Aug 1;14(15):2099-111 [15961413] Anal Biochem. 2005 Aug 15;343(2):350-2 [15963941] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13670-5 [16155123] Mol Cell Biol. 2005 Nov;25(22):10190-201 [16260631] Hum Mol Genet. 2005 Dec 15;14(24):3801-11 [16239241] J Neurosci. 2006 Jan 4;26(1):41-50 [16399671] Biochem Biophys Res Commun. 2006 Mar 31;342(1):330-5 [16480958] Nat Rev Neurosci. 2006 Mar;7(3):207-19 [16495942] Neurobiol Dis. 2006 Mar;21(3):541-8 [16298531] Biophys J. 2006 Jun 15;90(12):4692-700 [16581836] Nature. 2006 Jun 29;441(7097):1157-61 [16672980] Nature. 2006 Jun 29;441(7097):1162-6 [16672981] J Mol Biol. 2006 Jul 7;360(2):386-97 [16762368] Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10793-8 [16818890] J Neurosci. 2006 Sep 27;26(39):10068-78 [17005870] Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15091-6 [17015834] Nature. 2006 Oct 19;443(7113):787-95 [17051205] Chem Biol Interact. 2006 Oct 27;163(1-2):29-37 [16737690] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yexcr.2008.03.012 ER - TY - CPAPER T1 - New Techniques and Applications in Biomolecular Solid State NMR T2 - 40th Central Regional Meeting of the American Chemical Society (CERMACS 2008) AN - 41074180; 4916630 JF - 40th Central Regional Meeting of the American Chemical Society (CERMACS 2008) AU - Tycko, Robert Y1 - 2008/06/10/ PY - 2008 DA - 2008 Jun 10 KW - N.M.R. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41074180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2008%29&rft.atitle=New+Techniques+and+Applications+in+Biomolecular+Solid+State+NMR&rft.au=Tycko%2C+Robert&rft.aulast=Tycko&rft.aufirst=Robert&rft.date=2008-06-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Central+Regional+Meeting+of+the+American+Chemical+Society+%28CERMACS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cermacs2008.org/site/ProgramBook-Final3.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells AN - 20824958; 8302927 AB - We analyzed interleukin (IL) 12 and IL-23 production by monocyte-derived dendritic cells (mono-DCs). Mycobacterium tuberculosis H37Rv and zymosan preferentially induced IL-23. IL-23 but not IL-12 was efficiently induced by the combination of nucleotide-binding oligodimerization domain and Toll-like receptor (TLR) 2 ligands, which mimics activation by M. tuberculosis, or by the human dectin-1 ligand b-glucan alone or in combination with TLR2 ligands, mimicking induction by zymosan. TLR2 ligands inhibited IL-12 and increased IL-23 production. DC priming with interferon (IFN) g strongly increased IL-12 production, but was not required for IL-23 production and inhibited IL-23 production induced by b-glucan. The pattern of IL-12 and IL-23 induction was reflected in accumulation of the IL-12p35 and IL-23p19 transcripts, respectively, but not IL-12/23p40. Although IL-23, transforming growth factor b, and IL-6 contained in the supernatants of activated mono-DCs played a role in the induction of IL-17 by human CD4 super(+) T cells, IL-1b, in combination with one or more of those factors, was required for IL-17 production, and its production determined the differential ability of the stimuli used to elicit mono-DCs to produce soluble factors directing IL-17 production. Thus, the differential ability of pathogens to induce antigen-presenting cells to produce cytokines regulates the immune response to infection. JF - Journal of Experimental Medicine AU - Gerosa, Franca AU - Baldani-Guerra, Barbara AU - Lyakh, Lyudmila A AU - Batoni, Giovanna AU - Esin, Semih AU - Winkler-Pickett, Robin T AU - Consolaro, Maria Rita AU - De Marchi, Mario AU - Giachino, Daniela AU - Robbiano, Angela AU - Astegiano, Marco AU - Sambataro, Angela AU - Kastelein, Robert A AU - Carra, Giuseppe AU - Trinchieri, Giorgio AD - Department of Pathology, Section of Immunology, University of Verona, 37134 Verona, Italy. Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702. Department of Experimental Pathology, Medical Biotechnology, Infectivology and Epidemiology, University of Pisa, 56126 Pisa, Italy. Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Italy. Gastroenterology Unit, Azienda Sanitaria Ospedaliera San Giovanni Battista, 10126 Torino, Italy. Gastroenterology Unit, Azienda Sanitaria Ospedaliera San Luigi, 10043 Orbassano, Italy. Discovery Research, Schering-Plough Biopharma, Palo Alto, CA 94304 Y1 - 2008/06/09/ PY - 2008 DA - 2008 Jun 09 SP - 1447 EP - 1461 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 205 IS - 6 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Mimicry KW - g-Interferon KW - TLR2 protein KW - Interleukin 1 KW - Pathogens KW - Infection KW - Interferon KW - Dendritic cells KW - Interleukin 12 KW - CD4 antigen KW - Interleukin 23 KW - Interleukin 17 KW - Lymphocytes T KW - Transforming growth factor-b KW - Tuberculosis KW - Immune response KW - Antigen-presenting cells KW - Monocytes KW - b-Glucan KW - Toll-like receptors KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20824958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Differential+regulation+of+interleukin+12+and+interleukin+23+production+in+human+dendritic+cells&rft.au=Gerosa%2C+Franca%3BBaldani-Guerra%2C+Barbara%3BLyakh%2C+Lyudmila+A%3BBatoni%2C+Giovanna%3BEsin%2C+Semih%3BWinkler-Pickett%2C+Robin+T%3BConsolaro%2C+Maria+Rita%3BDe+Marchi%2C+Mario%3BGiachino%2C+Daniela%3BRobbiano%2C+Angela%3BAstegiano%2C+Marco%3BSambataro%2C+Angela%3BKastelein%2C+Robert+A%3BCarra%2C+Giuseppe%3BTrinchieri%2C+Giorgio&rft.aulast=Gerosa&rft.aufirst=Franca&rft.date=2008-06-09&rft.volume=205&rft.issue=6&rft.spage=1447&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Mimicry; g-Interferon; Interleukin 1; TLR2 protein; Pathogens; Infection; Interleukin 12; Dendritic cells; Interferon; CD4 antigen; Interleukin 23; Interleukin 17; Lymphocytes T; Transforming growth factor-b; Tuberculosis; Monocytes; Antigen-presenting cells; Immune response; Toll-like receptors; b-Glucan; Mycobacterium tuberculosis ER - TY - CPAPER T1 - Structures of the Plasmodium falciparum VAR2CSA DBL3x Domain and its Complex with Chondroitin Sulfate A that is Implicated in Pregnancy-Associated Malaria T2 - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AN - 40966486; 4871281 JF - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AU - Singh, Kavita Y1 - 2008/06/08/ PY - 2008 DA - 2008 Jun 08 KW - Sulfate KW - Malaria KW - Pregnancy KW - Chondroitin sulfate KW - Parasites KW - Public health KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40966486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.atitle=Structures+of+the+Plasmodium+falciparum+VAR2CSA+DBL3x+Domain+and+its+Complex+with+Chondroitin+Sulfate+A+that+is+Implicated+in+Pregnancy-Associated+Malaria&rft.au=Singh%2C+Kavita&rft.aulast=Singh&rft.aufirst=Kavita&rft.date=2008-06-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of P. falciparum Infection on the Development and Maintenance of Memory B Cells T2 - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AN - 40965423; 4871231 JF - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AU - Weiss, Greta Y1 - 2008/06/08/ PY - 2008 DA - 2008 Jun 08 KW - Infection KW - Lymphocytes B KW - Memory cells KW - Immunological memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40965423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.atitle=The+Impact+of+P.+falciparum+Infection+on+the+Development+and+Maintenance+of+Memory+B+Cells&rft.au=Weiss%2C+Greta&rft.aulast=Weiss&rft.aufirst=Greta&rft.date=2008-06-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Why a Malaria Vaccine is Possible T2 - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AN - 40964266; 4871270 JF - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AU - Miller, Louis H Y1 - 2008/06/08/ PY - 2008 DA - 2008 Jun 08 KW - Vaccines KW - Malaria KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.atitle=Why+a+Malaria+Vaccine+is+Possible&rft.au=Miller%2C+Louis+H&rft.aulast=Miller&rft.aufirst=Louis&rft.date=2008-06-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Generation and Maintenance of B Cell Immunological Memory in Response to Plasmodium falciparum T2 - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AN - 40964181; 4871239 JF - 2008 Keystone Symposia on Malaria: Immunology, Pathogenesis and Vaccine Perspectives (E3) AU - Pierce, Susan K Y1 - 2008/06/08/ PY - 2008 DA - 2008 Jun 08 KW - Lymphocytes B KW - Immunological memory KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.atitle=The+Generation+and+Maintenance+of+B+Cell+Immunological+Memory+in+Response+to+Plasmodium+falciparum&rft.au=Pierce%2C+Susan+K&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2008-06-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Malaria%3A+Immunology%2C+Pathogenesis+and+Vaccine+Perspectives+%28E3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Dissection of the bacteriophage T4 late promoter complex. AN - 70764115; 18455735 AB - Activated transcription of the bacteriophage T4 late genes is generated by a mechanism that stands apart from the common modalities of transcriptional regulation: the activator is gp45, the viral replisome's sliding clamp; two sliding-clamp-binding proteins, gp33 and gp55, replace the host RNA polymerase (RNAP) sigma subunit. We have mutagenized, reconfigured and selectively disrupted individual interactions of the sliding clamp with gp33 and gp55 and have monitored effects on transcription. The C-terminal sliding-clamp-binding epitopes of gp33 and gp55 are perfectly interchangeable, but the functions of these two RNAP-sliding clamp connections differ: only the gp33-gp45 linkage is essential for activation, while loss of the gp55-gp45 linkage impairs but does not abolish activation. Formation of transcription-ready promoter complexes by the sliding-clamp-activated wild-type T4 RNAP resists competition by high concentrations of the polyanion heparin. This avid formation of promoter complexes requires both linkages of the T4 late RNAP to the sliding clamp. Preopening the promoter compensates for loss of the gp55-gp45 but not the gp33-gp45 linkage. We interpret the relationship of these findings and our prior analysis to the common model of transcriptional initiation in bacteria in terms of two parallel pathways, with two RNAP holoenzymes and two DNA templates: (1) gp55-RNAP and the T4 late promoter execute basal transcription; (2) gp55-gp33-RNAP and the T4 late promoter with its mobile enhancer, the T4 sliding clamp, execute activated transcription. gp55 and gp33 perform sigma-like functions, gp55 in promoter recognition and gp33 (as well as gp55) in enhancer recognition. gp33 operates the switch between these two pathways by repressing basal transcription. JF - Journal of molecular biology AU - Nechaev, Sergei AU - Geiduschek, E Peter AD - Division of Biological Sciences and Center for Molecular Genetics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0634, USA. nechaevs@niehs.nih.gov Y1 - 2008/06/06/ PY - 2008 DA - 2008 Jun 06 SP - 402 EP - 413 VL - 379 IS - 3 KW - Macromolecular Substances KW - 0 KW - Viral Proteins KW - DNA-Directed RNA Polymerases KW - EC 2.7.7.6 KW - RNA polymerase alpha subunit KW - Index Medicus KW - Enzyme Activation KW - DNA-Directed RNA Polymerases -- metabolism KW - DNA Mutational Analysis KW - Protein Conformation KW - DNA-Directed RNA Polymerases -- genetics KW - Viral Proteins -- genetics KW - Promoter Regions, Genetic KW - Bacteriophage T4 -- metabolism KW - Viral Proteins -- metabolism KW - Transcription, Genetic KW - Bacteriophage T4 -- genetics KW - Macromolecular Substances -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70764115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Dissection+of+the+bacteriophage+T4+late+promoter+complex.&rft.au=Nechaev%2C+Sergei%3BGeiduschek%2C+E+Peter&rft.aulast=Nechaev&rft.aufirst=Sergei&rft.date=2008-06-06&rft.volume=379&rft.issue=3&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/10.1016%2Fj.jmb.2008.03.071 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-23 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Biol Evol. 2006 Sep;23(9):1688-96 [16782763] Virol J. 2006;3:30 [16716236] Virology. 2007 Jun 5;362(2):384-96 [17289101] Proc Natl Acad Sci U S A. 2007 May 8;104(19):7833-8 [17470797] J Biol Chem. 2007 Jul 20;282(29):21319-26 [17507375] Biochem Biophys Res Commun. 1968 Feb 15;30(3):240-7 [4869542] J Biol Chem. 1977 Aug 10;252(15):5403-7 [328501] Proc Natl Acad Sci U S A. 1984 Aug;81(16):5101-5 [6382259] Nucleic Acids Res. 1986 Aug 26;14(16):6745-63 [3092189] Science. 1990 May 4;248(4955):573-8 [2185541] Science. 1992 May 29;256(5061):1298-303 [1598572] Science. 1993 Nov 26;262(5138):1407-13 [8248780] Cell. 1994 Apr 22;77(2):225-37 [8168131] EMBO J. 1994 Nov 15;13(22):5330-7 [7957099] EMBO J. 1996 Aug 15;15(16):4414-22 [8861968] J Mol Biol. 1997 Mar 21;267(1):60-74 [9096207] J Mol Biol. 1998 Nov 27;284(2):195-203 [9813112] J Mol Biol. 1999 Aug 13;291(2):267-81 [10438620] J Biol Chem. 1999 Aug 27;274(35):24485-9 [10455110] Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17365-70 [15574501] EMBO J. 2006 Apr 19;25(8):1700-9 [16601684] Cell. 1999 Oct 15;99(2):155-66 [10535734] J Mol Biol. 2000 Mar 10;296(5):1215-23 [10698628] Trends Biochem Sci. 2001 Sep;26(9):566-72 [11551794] J Mol Biol. 2002 Aug 30;321(5):767-84 [12206760] J Biol Chem. 2003 Feb 28;278(9):7073-80 [12496274] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4554-9 [15070756] Eur J Biochem. 1967 Dec;3(2):194-201 [4865568] Cell. 2006 Jun 16;125(6):1069-82 [16777598] J Mol Biol. 2006 Aug 4;361(1):46-68 [16828113] EMBO J. 2007 Feb 21;26(4):955-64 [17268549] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jmb.2008.03.071 ER - TY - JOUR T1 - An ENU-induced mutation in the lymphotoxin alpha gene impairs organogenesis of lymphoid tissues in C57BL/6 mice. AN - 69177216; 18384745 AB - The TNF family is critical for development of lymphoid organs and plays significant roles in regulation of innate and adoptive immune responses. Here, we describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutant strain, HLB382, with a point mutation in the Lta gene, which encodes lymphotoxin (LT) alpha, a member of the TNF family. Mutant mice had no lymph nodes and no Peyer's patches. Microscopically, the spleens had disordered follicles and no germinal centers or discernible marginal zones (MZ). While the development of T cells and follicular B cells was normal, the numbers of NK and MZ B cells were significantly reduced. Interestingly, the numbers of peritoneal B1b cells were significantly increased. Genomic DNA sequences revealed a single base pair insertion in the coding region of Lta resulting in a frame shift and a premature stop codon. This new strain provides opportunities for understanding the full range of Lta gene function on a pure C57BL/6 background. JF - Biochemical and biophysical research communications AU - Wang, Hongsheng AU - Feng, Jianxun AU - Qi, Chenfeng AU - Morse, Herbert C AD - Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers LN, TB1, Rm 1518, Rockville, MD 20852, USA. wanghongs@niaid.nih.gov Y1 - 2008/06/06/ PY - 2008 DA - 2008 Jun 06 SP - 461 EP - 467 VL - 370 IS - 3 KW - Lymphotoxin-alpha KW - 0 KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Animals KW - Dendritic Cells -- immunology KW - Ethylnitrosourea -- toxicity KW - Point Mutation KW - Granulocytes -- immunology KW - Mice KW - B-Lymphocytes -- immunology KW - Chromosome Mapping KW - T-Lymphocytes -- immunology KW - Peritoneum -- immunology KW - Killer Cells, Natural -- immunology KW - Bone Marrow -- immunology KW - Peyer's Patches -- immunology KW - Lymphotoxin-alpha -- genetics KW - Peyer's Patches -- cytology KW - Lymph Nodes -- abnormalities KW - Peyer's Patches -- abnormalities KW - Mice, Inbred C57BL KW - Lymphotoxin-alpha -- physiology KW - Lymph Nodes -- cytology KW - Organogenesis -- genetics KW - Lymph Nodes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69177216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=An+ENU-induced+mutation+in+the+lymphotoxin+alpha+gene+impairs+organogenesis+of+lymphoid+tissues+in+C57BL%2F6+mice.&rft.au=Wang%2C+Hongsheng%3BFeng%2C+Jianxun%3BQi%2C+Chenfeng%3BMorse%2C+Herbert+C&rft.aulast=Wang&rft.aufirst=Hongsheng&rft.date=2008-06-06&rft.volume=370&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=1090-2104&rft_id=info:doi/10.1016%2Fj.bbrc.2008.03.118 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunol Cell Biol. 2001 Feb;79(1):54-61 [11168624] Mamm Genome. 2007 Feb;18(2):123-4 [17347895] Eur J Immunol. 2001 Jun;31(6):1935-43 [11433391] J Immunol. 2001 Aug 1;167(3):1254-62 [11466341] Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):275-88 [12787565] Mamm Genome. 2004 Aug;15(8):585-91 [15457338] Nature. 1987 Jan 15-21;325(6101):265-7 [3027565] Science. 1994 Apr 29;264(5159):703-7 [8171322] J Immunol. 1995 Jan 1;154(1):239-46 [7995944] Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):674-8 [7846035] J Immunol. 1995 Aug 15;155(4):1685-93 [7636227] Proc Natl Acad Sci U S A. 1997 May 27;94(11):5739-43 [9159143] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6319-23 [9177215] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8093-8 [9223320] J Immunol. 1997 Oct 1;159(7):3288-98 [9317127] J Exp Med. 1998 May 4;187(9):1517-28 [9565643] J Exp Med. 1998 Jun 15;187(12):1977-83 [9625757] J Exp Med. 1998 Aug 17;188(4):745-54 [9705956] Environ Mol Mutagen. 1999;33(1):42-8 [10037322] Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3000-5 [10077626] J Immunol. 1999 Aug 1;163(3):1350-3 [10415034] J Immunol. 1999 Sep 1;163(5):2809-15 [10453025] Hum Mol Genet. 1999;8(10):1955-63 [10469849] Eur J Immunol. 2005 May;35(5):1592-600 [15832287] Leuk Res. 2006 Feb;30(2):153-63 [16122798] Mol Cell Biol. 2006 Jun;26(11):4214-25 [16705172] Dev Immunol. 2000;8(1):61-74 [11293812] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbrc.2008.03.118 ER - TY - CPAPER T1 - Accumulation of Tumor Infiltrating FOXP3+ CD4+ Regulatory T Cells in Tumors and Not in Peripheral Blood in Patients with Melanoma T2 - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AN - 41058796; 4910947 JF - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AU - Ahmadzadeh, Mojgan AU - Felipe-Silva, Aloisio AU - Merino, Maria AU - Rosenberg, Steven Y1 - 2008/06/05/ PY - 2008 DA - 2008 Jun 05 KW - Tumors KW - Melanoma KW - Lymphocytes T KW - Immunoregulation KW - CD4 antigen KW - Foxp3 protein KW - Peripheral blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41058796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.atitle=Accumulation+of+Tumor+Infiltrating+FOXP3%2B+CD4%2B+Regulatory+T+Cells+in+Tumors+and+Not+in+Peripheral+Blood+in+Patients+with+Melanoma&rft.au=Ahmadzadeh%2C+Mojgan%3BFelipe-Silva%2C+Aloisio%3BMerino%2C+Maria%3BRosenberg%2C+Steven&rft.aulast=Ahmadzadeh&rft.aufirst=Mojgan&rft.date=2008-06-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am08/FOCIS_2008_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory Response and Involvement of Immune Components in a Laser Induced CNV (Choroid neovascularization) Mouse Model T2 - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AN - 41057777; 4911270 JF - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AU - Li, Zhuqing AU - Liu, Baoying AU - Mahesh, Sankaranarayana AU - Yeh, Steven AU - Fariss, Robert AU - Campos, Mercia AU - Nussenblatt, Robert Y1 - 2008/06/05/ PY - 2008 DA - 2008 Jun 05 KW - Lasers KW - Animal models KW - Vascularization KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41057777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.atitle=Inflammatory+Response+and+Involvement+of+Immune+Components+in+a+Laser+Induced+CNV+%28Choroid+neovascularization%29+Mouse+Model&rft.au=Li%2C+Zhuqing%3BLiu%2C+Baoying%3BMahesh%2C+Sankaranarayana%3BYeh%2C+Steven%3BFariss%2C+Robert%3BCampos%2C+Mercia%3BNussenblatt%2C+Robert&rft.aulast=Li&rft.aufirst=Zhuqing&rft.date=2008-06-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am08/FOCIS_2008_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Absent TH17 Responses in Patients with Hyper-IgE Syndrome and STAT3 Mutation T2 - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AN - 41056762; 4910864 JF - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AU - Milner, Joshua AU - Brenchley, Jason AU - Laurence, Arian AU - Freeman, Alexandra AU - Elias, Kevin AU - Hsu, Amy AU - Spalding, Christine AU - Davis, Joie AU - O'Shea, John AU - Holland, Steven AU - Paul, William AU - Douek, Daniel Y1 - 2008/06/05/ PY - 2008 DA - 2008 Jun 05 KW - Mutation KW - Stat3 protein KW - Job's syndrome KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41056762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.atitle=Absent+TH17+Responses+in+Patients+with+Hyper-IgE+Syndrome+and+STAT3+Mutation&rft.au=Milner%2C+Joshua%3BBrenchley%2C+Jason%3BLaurence%2C+Arian%3BFreeman%2C+Alexandra%3BElias%2C+Kevin%3BHsu%2C+Amy%3BSpalding%2C+Christine%3BDavis%2C+Joie%3BO%27Shea%2C+John%3BHolland%2C+Steven%3BPaul%2C+William%3BDouek%2C+Daniel&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2008-06-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am08/FOCIS_2008_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PD-1 is Expressed by Human Tumor Infiltrating T Cells in Tumors but Not in Peripheral Blood and its Expression Correlates with Impaired Effector Function T2 - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AN - 41055304; 4911277 JF - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AU - Ahmadzadeh, Mojgan AU - Rosenberg, Steven Y1 - 2008/06/05/ PY - 2008 DA - 2008 Jun 05 KW - Tumors KW - Lymphocytes T KW - PD-1 protein KW - Peripheral blood KW - Tumor-infiltrating lymphocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41055304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.atitle=PD-1+is+Expressed+by+Human+Tumor+Infiltrating+T+Cells+in+Tumors+but+Not+in+Peripheral+Blood+and+its+Expression+Correlates+with+Impaired+Effector+Function&rft.au=Ahmadzadeh%2C+Mojgan%3BRosenberg%2C+Steven&rft.aulast=Ahmadzadeh&rft.aufirst=Mojgan&rft.date=2008-06-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am08/FOCIS_2008_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss of SAP Expression in XLP Patient T Cells Impairs TCR-induced Apoptosis Independent of EBV Infection T2 - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AN - 41053334; 4910866 JF - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AU - Snow, Andrew AU - Marsh, Rebecca AU - Roehrs, Philip AU - Young, Lisa AU - van Hoff, Jack AU - Zhang, Kejian AU - Filipovich, Alexandra AU - Su, Helen AU - Bleesing, Jack AU - Lenardo, Michael Y1 - 2008/06/05/ PY - 2008 DA - 2008 Jun 05 KW - Infection KW - T-cell receptor KW - Apoptosis KW - Lymphocytes T KW - SAP protein KW - Epstein-Barr virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41053334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.atitle=Loss+of+SAP+Expression+in+XLP+Patient+T+Cells+Impairs+TCR-induced+Apoptosis+Independent+of+EBV+Infection&rft.au=Snow%2C+Andrew%3BMarsh%2C+Rebecca%3BRoehrs%2C+Philip%3BYoung%2C+Lisa%3Bvan+Hoff%2C+Jack%3BZhang%2C+Kejian%3BFilipovich%2C+Alexandra%3BSu%2C+Helen%3BBleesing%2C+Jack%3BLenardo%2C+Michael&rft.aulast=Snow&rft.aufirst=Andrew&rft.date=2008-06-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am08/FOCIS_2008_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Short Stature in Partially Corrected X-Linked Severe Combined Immunodeficiency- Suboptimal Response to Growth Hormone and Treatment using Recombinant Human IGF-1 T2 - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AN - 41053027; 4911040 JF - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AU - De Ravin, Suk AU - Rezvani, Geoffrey AU - Zarember, Kol AU - Stratakis, Constantine AU - Malech, Harry Y1 - 2008/06/05/ PY - 2008 DA - 2008 Jun 05 KW - Hormones KW - Growth hormone KW - Body height KW - X chromosome KW - Insulin-like growth factor I KW - Growth KW - Recombinants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41053027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.atitle=Short+Stature+in+Partially+Corrected+X-Linked+Severe+Combined+Immunodeficiency-+Suboptimal+Response+to+Growth+Hormone+and+Treatment+using+Recombinant+Human+IGF-1&rft.au=De+Ravin%2C+Suk%3BRezvani%2C+Geoffrey%3BZarember%2C+Kol%3BStratakis%2C+Constantine%3BMalech%2C+Harry&rft.aulast=De+Ravin&rft.aufirst=Suk&rft.date=2008-06-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am08/FOCIS_2008_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lack of High Affinity Competition during Antigen-specific Priming of Polyclonal T Cells Unmasks IL-4 Production T2 - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AN - 41049734; 4910868 JF - 2008 Federation of Clinical Immunology Societies Conference (FOCIS 2008) AU - Milner, Joshua Y1 - 2008/06/05/ PY - 2008 DA - 2008 Jun 05 KW - Competition KW - Lymphocytes T KW - Interleukin 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41049734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.atitle=Lack+of+High+Affinity+Competition+during+Antigen-specific+Priming+of+Polyclonal+T+Cells+Unmasks+IL-4+Production&rft.au=Milner%2C+Joshua&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2008-06-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Federation+of+Clinical+Immunology+Societies+Conference+%28FOCIS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.focisnet.org/meetings/am08/FOCIS_2008_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Serum Vitamin D Concentration and Prostate Cancer Risk: A Nested Case-Control Study AN - 20731588; 8303349 AB - BACKGROUND: Epidemiological studies have yielded inconsistent associations between vitamin D status and prostate cancer risk, and few studies have evaluated whether the associations vary by disease aggressiveness. We investigated the association between vitamin D status, as determined by serum 25-hydroxyvitamin D [25(OH)D] level, and risk of prostate cancer in a case-control study nested within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. METHODS: The study included 749 case patients with incident prostate cancer who were diagnosed 1-8 years after blood draw and 781 control subjects who were frequency matched by age at cohort entry, time since initial screening, and calendar year of cohort entry. All study participants were selected from the trial screening arm (which includes annual standardized prostate cancer screening). Conditional logistic regression was used to estimate adjusted odds ratios (ORs) with 95% confidence intervals (CIs) by quintile of season-standardized serum 25(OH)D concentration. Statistical tests were two-sided. RESULTS: No statistically significant trend in overall prostate cancer risk was observed with increasing season-standardized serum 25(OH)D level. However, serum 25(OH)D concentrations greater than the lowest quintile (Q1) were associated with increased risk of aggressive (Gleason sum greater than or equal to 7 or clinical stage III or IV) disease (in a model adjusting for matching factors, study center, and history of diabetes, ORs for Q2 vs Q1 = 1.20, 95% CI = 0.80 to 1.81, for Q3 vs Q1 =1.96, 95% CI = 1.34 to 2.87, for Q4 vs Q1 = 1.61, 95% CI = 1.09 to 2.38, and for Q5 vs Q1 = 1.37, 95% CI = 0.92 to 2.05; P sub(trend) = .05). The rates of aggressive prostate cancer for increasing quintiles of serum 25(OH)D were 406, 479, 780, 633, and 544 per 100 000 person-years. In exploratory analyses, these associations with aggressive disease were consistent across subgroups defined by age, family history of prostate cancer, diabetes, body mass index, vigorous physical activity, calcium intake, study center, season of blood collection, and assay batch. CONCLUSION: The findings of this large prospective study do not support the hypothesis that vitamin D is associated with decreased risk of prostate cancer; indeed, higher circulating 25(OH)D concentrations may be associated with increased risk of aggressive disease. JF - Journal of the National Cancer Institute AU - Ahn, Jiyoung AU - Peters, Ulrike AU - Albanes, Demetrius AU - Purdue, Mark P AU - Abnet, Christian C AU - Chatterjee, Nilanjan AU - Horst, Ronald L AU - Hollis, Bruce W AU - Huang, Wen-Yi AU - Shikany, James M AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (JA, DA, MPP, CCA, NC, WYH, RBH) Y1 - 2008/06/04/ PY - 2008 DA - 2008 Jun 04 SP - 796 EP - 804 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 100 IS - 11 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Historical account KW - Age KW - Calcium KW - aggressive behavior KW - Genetics KW - diabetes mellitus KW - vitamins KW - body mass KW - physical activity KW - prostate cancer KW - Cancer KW - Lung KW - Standards KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20731588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Serum+Vitamin+D+Concentration+and+Prostate+Cancer+Risk%3A+A+Nested+Case-Control+Study&rft.au=Ahn%2C+Jiyoung%3BPeters%2C+Ulrike%3BAlbanes%2C+Demetrius%3BPurdue%2C+Mark+P%3BAbnet%2C+Christian+C%3BChatterjee%2C+Nilanjan%3BHorst%2C+Ronald+L%3BHollis%2C+Bruce+W%3BHuang%2C+Wen-Yi%3BShikany%2C+James+M%3BHayes%2C+Richard+B&rft.aulast=Ahn&rft.aufirst=Jiyoung&rft.date=2008-06-04&rft.volume=100&rft.issue=11&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - prostate cancer; Cancer; vitamins; diabetes mellitus; Age; Genetics; Standards; Calcium; aggressive behavior; body mass; Historical account; Lung; physical activity ER - TY - JOUR T1 - Cdx gene deficiency compromises embryonic hematopoiesis in the mouse. AN - 71641421; 18511567 AB - Cdx genes (Cdx1, Cdx2, and Cdx4) encode a family of caudal-related transcription factors that mediate anterior-posterior patterning during embryogenesis through Hox gene regulation. Homologues in the zebrafish have been shown to play key roles in blood formation. To define the role of Cdx genes during embryonic hematopoiesis in a mammalian system, we examined the hematopoietic potential of Cdx-deficient mouse embryonic stem cells (ESCs) in vitro and in vivo. Individual Cdx-deficient ESCs exhibited impaired embryonic hematopoietic progenitor formation and altered Hox gene expression, most notably for Cdx2 deficiency. A more severe hematopoietic defect was observed with compound Cdx deficiency than loss of function of any single Cdx gene. Reduced hematopoietic progenitor formation of ESCs deficient in multiple Cdx genes could be rescued by ectopic expression of Cdx4, concomitant with partially restored Hox gene expression. These results reveal an essential and partially redundant role for multiple Cdx genes during embryonic hematopoiesis in the mouse. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Wang, Yuan AU - Yabuuchi, Akiko AU - McKinney-Freeman, Shannon AU - Ducharme, Danica M K AU - Ray, Manas K AU - Chawengsaksophak, Kallayanee AU - Archer, Trevor K AU - Daley, George Q AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/06/03/ PY - 2008 DA - 2008 Jun 03 SP - 7756 EP - 7761 VL - 105 IS - 22 KW - CDX2 Transcription Factor KW - 0 KW - Cdx1 protein, mouse KW - Cdx2 protein, mouse KW - Cdx4 protein, mouse KW - Homeodomain Proteins KW - Transcription Factors KW - Index Medicus KW - Animals KW - Mice KW - Mice, Knockout KW - Transcription Factors -- physiology KW - Embryonic Stem Cells -- metabolism KW - Embryonic Stem Cells -- cytology KW - Homeodomain Proteins -- genetics KW - Homeodomain Proteins -- physiology KW - Hematopoietic Stem Cells -- cytology KW - Embryo, Mammalian -- cytology KW - Hematopoietic Stem Cells -- metabolism KW - Embryo, Mammalian -- metabolism KW - Transcription Factors -- genetics KW - Hematopoiesis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71641421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Cdx+gene+deficiency+compromises+embryonic+hematopoiesis+in+the+mouse.&rft.au=Wang%2C+Yuan%3BYabuuchi%2C+Akiko%3BMcKinney-Freeman%2C+Shannon%3BDucharme%2C+Danica+M+K%3BRay%2C+Manas+K%3BChawengsaksophak%2C+Kallayanee%3BArcher%2C+Trevor+K%3BDaley%2C+George+Q&rft.aulast=Wang&rft.aufirst=Yuan&rft.date=2008-06-03&rft.volume=105&rft.issue=22&rft.spage=7756&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0708951105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-24 N1 - Date created - 2008-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Development. 2002 Apr;129(8):2003-13 [11934866] Methods Enzymol. 2006;420:49-64 [17161693] Development. 2002 May;129(9):2181-93 [11959827] Nat Rev Immunol. 2002 Aug;2(8):593-604 [12154378] Nature. 2003 Sep 18;425(6955):300-6 [13679919] Bioessays. 2003 Oct;25(10):971-80 [14505364] Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):817-22 [14718672] Curr Top Dev Biol. 2004;60:127-96 [15094298] Proc Natl Acad Sci U S A. 2004 May 18;101(20):7641-5 [15136723] Development. 1993 Jan;117(1):191-203 [7900985] Methods Enzymol. 1993;225:803-23 [8231888] Mech Dev. 1993 Sep;43(1):71-81 [7902125] Cell. 1994 Jul 29;78(2):191-201 [7913880] Science. 1994 Aug 19;265(5175):1098-101 [8066449] Cell. 1995 Nov 17;83(4):641-53 [7585967] Dev Dyn. 1995 Nov;204(3):219-27 [8573715] Nature. 1997 Mar 6;386(6620):84-7 [9052785] Nature. 1997 Apr 3;386(6624):488-93 [9087406] Cell. 1998 May 1;93(3):397-409 [9590174] Development. 1998 Nov;125(22):4349-58 [9778495] Cell. 1999 Jul 23;98(2):181-91 [10428030] Curr Biol. 2004 Nov 23;14(22):2063-9 [15556871] Nature. 2004 Dec 2;432(7017):625-30 [15577911] Curr Opin Hematol. 2005 May;12(3):210-6 [15867577] Int J Dev Biol. 2005;49(8):901-8 [16281167] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19081-6 [16357205] Development. 2006 Feb;133(3):419-28 [16396910] Dev Biol. 2006 Apr 15;292(2):506-18 [16457800] Curr Opin Hematol. 2006 Jul;13(4):237-42 [16755219] Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16924-9 [17068127] Cell. 2002 Apr 5;109(1):29-37 [11955444] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0708951105 ER - TY - JOUR T1 - ER Biogenesis: Self-Assembly of Tubular Topology by Protein Hairpins AN - 20824140; 8349114 AB - The structure of the endoplasmic reticulum (ER) depends on members of the reticulon and DP1/Yop1p families. Two of these proteins are sufficient to form tubular membrane networks from pure phospholipid vesicles, thus revealing a new paradigm of ER morphogenesis. JF - Current Biology AU - Shnyrova, A AU - Frolov, V A AU - Zimmerberg, J AD - Program on Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1855, USA, joshz@helix.nih.gov Y1 - 2008/06/03/ PY - 2008 DA - 2008 Jun 03 SP - R474 EP - R476 VL - 18 IS - 11 SN - 0960-9822, 0960-9822 KW - Biotechnology and Bioengineering Abstracts KW - Endoplasmic reticulum KW - Self-assembly KW - Morphogenesis KW - Vesicles KW - Phospholipids KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20824140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=ER+Biogenesis%3A+Self-Assembly+of+Tubular+Topology+by+Protein+Hairpins&rft.au=Shnyrova%2C+A%3BFrolov%2C+V+A%3BZimmerberg%2C+J&rft.aulast=Shnyrova&rft.aufirst=A&rft.date=2008-06-03&rft.volume=18&rft.issue=11&rft.spage=R474&rft.isbn=&rft.btitle=&rft.title=Current+Biology&rft.issn=09609822&rft_id=info:doi/10.1016%2Fj.cub.2008.04.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Self-assembly; Endoplasmic reticulum; Phospholipids; Vesicles; Morphogenesis DO - http://dx.doi.org/10.1016/j.cub.2008.04.031 ER - TY - JOUR T1 - Rhabdomyoma of the parapharyngeal space presenting with dysphagia. AN - 85415446; pmid-17965913 AB - Rhabdomyoma is an exceedingly rare soft tissue benign tumor of skeletal muscle origin classified into cardiac and extracardiac types based on location. Extracardiac rhabdomyoma is further classified into adult, genital, and fetal type depending on the degree of differentiation. Adult rhabdomyomas are rare, but morphologically characteristic, benign mesenchymal tumors with mature skeletal muscle differentiation that in 90% of cases arise in the head and neck region, mainly in the mucosa of the oropharynx, nasopharynx, and larynx, from the branchial musculature of third and fourth branchial arches. Most patients are between 40 and 70 years old, with a mean age of 60 years with a male predominance. Usually presenting symptoms include upper airway obstruction, Eustachian tube dysfunction, and mucosal or neck mass, but rarely does it arise as pure dysphagia. This article presents a case of parapharyngeal rhabdomyoma presenting with only progressive dysphagia. JF - Dysphagia AU - Pichi, Barbara AU - Manciocco, Valentina AU - Marchesi, Paolo AU - Pellini, Raul AU - Ruscito, Paolo AU - Vidiri, Antonello AU - Covello, Renato AU - Spriano, Giusepe AD - Department of Otolaryngology, Head and Neck Surgery, National Cancer Institute Regina Elena, Via E. Chianesi 53, 00144 Rome, Italy. barbapichi@libero.it Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 202 EP - 204 VL - 23 IS - 2 SN - 0179-051X, 0179-051X KW - Index Medicus KW - National Library of Medicine KW - Deglutition Disorders: diagnosis KW - *Deglutition Disorders: etiology KW - Deglutition Disorders: physiopathology KW - Disease Progression KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - Middle Aged KW - *Oropharyngeal Neoplasms: complications KW - *Oropharyngeal Neoplasms: pathology KW - Oropharyngeal Neoplasms: surgery KW - *Rhabdomyoma: complications KW - *Rhabdomyoma: pathology KW - Rhabdomyoma: surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85415446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Rhabdomyoma+of+the+parapharyngeal+space+presenting+with+dysphagia.&rft.au=Pichi%2C+Barbara%3BManciocco%2C+Valentina%3BMarchesi%2C+Paolo%3BPellini%2C+Raul%3BRuscito%2C+Paolo%3BVidiri%2C+Antonello%3BCovello%2C+Renato%3BSpriano%2C+Giusepe&rft.aulast=Pichi&rft.aufirst=Barbara&rft.date=2008-06-01&rft.volume=23&rft.issue=2&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - AP214, an analogue of alpha -melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality AN - 807261500; 13631850 AB - Sepsis remains a serious problem in critically ill patients with the mortality increasing to over half when there is attendant acute kidney injury. alpha -Melanocyte-stimulating hormone is a potent anti-inflammatory cytokine that inhibits many forms of inflammation including that with acute kidney injury. We tested whether a new alpha -melanocyte-stimulating hormone analogue (AP214), which has increased binding affinity to melanocortin receptors, improves sepsis-induced kidney injury and mortality using a cecal ligation and puncture mouse model. In the lethal cecal ligation-puncture model of sepsis, severe hypotension and bradycardia resulted and AP214 attenuated acute kidney injury of the lethal model with a bell-shaped dose-response curve. An optimum AP214 dose reduced acute kidney injury even when it was administered 6h after surgery and it significantly improved blood pressure and heart rate. AP214 reduced serum TNF- alpha and IL-10 levels with a bell-shaped dose-response curve. Additionally; NF- Kappa B activation in the kidney and spleen, and splenocyte apoptosis were decreased by the treatment. AP214 significantly improved survival in both lethal and sublethal models. We have shown that AP214 improves hemodynamic failure, acute kidney injury, mortality and splenocyte apoptosis attenuating pro- and anti-inflammatory actions due to sepsis.Kidney International (2008) 73, 1266-1274; doi:10.1038/ki.2008.97; published online 19 March 2008 JF - Kidney International AU - Doi, K AU - Hu, X AU - Yuen, P S T AU - Leelahavanichkul, A AU - Yasuda, H AU - Kim, S M AU - Schnermann, J AU - Jonassen, T E N AU - Froekiaer, J AU - Nielsen, S AU - Star, R A AD - 1 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1266 EP - 1274 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 73 IS - 11 SN - 0085-2538, 0085-2538 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Splenocytes KW - Apoptosis KW - Injuries KW - Kidney KW - Animal models KW - Cecum KW - alpha -Melanocyte-stimulating hormone KW - Inflammation KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807261500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=AP214%2C+an+analogue+of+alpha+-melanocyte-stimulating+hormone%2C+ameliorates+sepsis-induced+acute+kidney+injury+and+mortality&rft.au=Doi%2C+K%3BHu%2C+X%3BYuen%2C+P+S+T%3BLeelahavanichkul%2C+A%3BYasuda%2C+H%3BKim%2C+S+M%3BSchnermann%2C+J%3BJonassen%2C+T+E+N%3BFroekiaer%2C+J%3BNielsen%2C+S%3BStar%2C+R+A&rft.aulast=Doi&rft.aufirst=K&rft.date=2008-06-01&rft.volume=73&rft.issue=11&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1038%2Fki.2008.97 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Splenocytes; Mortality; Apoptosis; Injuries; Animal models; Kidney; Cecum; alpha -Melanocyte-stimulating hormone; Inflammation DO - http://dx.doi.org/10.1038/ki.2008.97 ER - TY - JOUR T1 - Th17 cells: a new fate for differentiating helper T cells AN - 746297612; 12878975 AB - Classically naive CD4 have been thought to differentiate into two possible lineages, T helper 1 (Th1) or T helper 2 (Th2) cells. Within this paradigm the pathogenesis of autoimmunity was suggested to predominantly relate to Th1 cells and the production of IFN-*g. However, there were many aspects of this model that did not seem to fit, not the least of which was that IFN-*g was protective in some models of autoimmunity. During the past 2 years, remarkable progress has been made to characterize a new lineage of helper T cells. Designated Th17 cells, this lineage selectively produces proinflammatory cytokines including IL-17, IL-21, and IL-22. In the mouse, the differentiation of this new lineage is initiated by TGF*b-1 and IL-6 and IL-21, which activate Stat3 and induce the expression of the transcription factor retinoic acid-related orphan receptor (ROR*gt). IL-23, which also activates Stat3, apparently serves to maintain Th17 cells in vivo. In human cells, IL-1, IL-6, and IL-23 promote human Th17 differentiation, but TGF*b-1 is reportedly not needed. Emerging data have suggested that Th17 plays an essential role in the host defense against extracellular bacteria and fungi and in pathogenesis of autoimmune diseases. Selectively targeting the Th17 lineage may be beneficial for the treatment of inflammatory and autoimmune diseases. JF - Immunologic Research AU - Chen, Zhi AU - O'Shea, John J AD - Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA, zchen@utu.fi Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 87 EP - 102 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 41 IS - 2 SN - 0257-277X, 0257-277X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Interleukin 6 KW - Data processing KW - Orphan receptors KW - Stat3 protein KW - Fungi KW - Helper cells KW - Autoimmune diseases KW - Interleukin 1 KW - Animal models KW - Interleukin 21 KW - Inflammation KW - Differentiation KW - CD4 antigen KW - Interleukin 22 KW - Interleukin 23 KW - Inflammatory diseases KW - Transcription factors KW - Interleukin 17 KW - Lymphocytes T KW - K 03410:Animal Diseases KW - A 01490:Miscellaneous KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746297612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Th17+cells%3A+a+new+fate+for+differentiating+helper+T+cells&rft.au=Chen%2C+Zhi%3BO%27Shea%2C+John+J&rft.aulast=Chen&rft.aufirst=Zhi&rft.date=2008-06-01&rft.volume=41&rft.issue=2&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-007-8014-9 L2 - http://www.springerlink.com/content/980864x453146804/?p=576929b0d872425b97f2d573a2232d99&pi=0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Data processing; Stat3 protein; Orphan receptors; Helper cells; Fungi; Interleukin 1; Autoimmune diseases; Animal models; Interleukin 21; Inflammation; Differentiation; Interleukin 22; CD4 antigen; Interleukin 23; Inflammatory diseases; Interleukin 17; Transcription factors; Lymphocytes T DO - http://dx.doi.org/10.1007/s12026-007-8014-9 ER - TY - JOUR T1 - The Role of Type 1 and Type 2 5'-Deiodinase in the Pathophysiology of the 3,5,3'-Triiodothyronine Toxicosis of McCune-Albright Syndrome AN - 745929201; 8302786 AB - CONTEXT: McCune-Albright syndrome (MAS) is caused by mutations in GNAS (most often R201C or R201H) leading to constitutive cAMP signaling and multiple endocrine dysfunctions, including morphological and functional thyroid involvement. OBJECTIVE: The objective of the study was to characterize the clinical and molecular features of the MAS-associated thyroid disease in a large cohort of patients. DESIGN: This was a retrospective analysis. Setting: The study was conducted at the National Institutes of Health Clinical Center. PATIENTS: The study included 100 consecutive MAS patients. INTERVENTIONS: There were no interventions. MAIN OUTCOME MEASURE: Functional and morphological evaluation of the thyroid was measured. Ex vivo experiments were performed on MAS thyroid samples to study the effects of the GNAS mutations on the 5'-deiodinases. Reconstitution experiments in HEK-293 cells were performed to study the effects of GNAS mutations on the type-2 5'-deiodinase. RESULTS: Fifty-four patients had abnormal thyroid ultrasound findings. This group, compared with patients without abnormal findings, had higher T sub(3) to T sub(4) ratio, indicating an elevated 5'-deiodinase activity. Thyroid samples from MAS subjects, compared with normal tissue, showed a significant increase in both type 1 (D1) and type 2 (D2) 5'-deiodinase activity (D1 control 5.9 c 4.5 vs. MAS 41.7 c 26.8 fmol/min.mg, P < 0.001; D2 control 28.3 c 13.8 vs. MAS 153.1 c 43.7 fmol/min.mg, P < 0.001). Compared with cells transfected with the wild-type R201 allele, the basal transcriptional activity of the D2 promoter was significantly increased in both mutants (C and H) (R 10733 c 2855, vs. C 18548 c 4514, vs. H 19032 c 4410 RLU c SD, P < 0.001). CONCLUSION: Thyroid pathology is a common occurrence in MAS. Consistent with the molecular etiology of the disease, the shift in T sub(3) to T sub(4) ratio is at least in part secondary to a cAMP-mediated intrathyroidal activation of D2 and to elevated D1 activity. JF - Journal of Clinical Endocrinology and Metabolism AU - Celi, Francesco S AU - Coppotelli, Giuseppe AU - Chidakel, Aaron AU - Kelly, Marilyn AU - Brillante, Beth A AU - Shawker, Thomas AU - Cherman, Natasha AU - Feuillan, Penelope P AU - Collins, Michael T AD - Clinical Endocrinology Branch (F.S.C., G.C., A.C.), National Institute of Diabetes and Digestive and Kidney Diseases, and Skeletal Clinical Studies Unit (M.K., B.A.B., N.C., M.T.C.), Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, Radiology Department (T.S.), Mark O. Hatfield Clinical Center, National Human Genome Research Institute (P.P.F.), National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 2383 EP - 2389 PB - Endocrine Society, 4350 East West Highway Suite 500 Bethesda MD 20814-4426 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 93 IS - 6 SN - 0021-972X, 0021-972X KW - Toxicology Abstracts KW - Etiology KW - Cyclic AMP KW - toxicosis KW - Transcription KW - Triiodothyronine KW - Promoters KW - McCune-Albright syndrome KW - Thyroxine KW - thyroid diseases KW - Iodide peroxidase KW - Ultrasound KW - Mutation KW - Signal transduction KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745929201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=The+Role+of+Type+1+and+Type+2+5%27-Deiodinase+in+the+Pathophysiology+of+the+3%2C5%2C3%27-Triiodothyronine+Toxicosis+of+McCune-Albright+Syndrome&rft.au=Celi%2C+Francesco+S%3BCoppotelli%2C+Giuseppe%3BChidakel%2C+Aaron%3BKelly%2C+Marilyn%3BBrillante%2C+Beth+A%3BShawker%2C+Thomas%3BCherman%2C+Natasha%3BFeuillan%2C+Penelope+P%3BCollins%2C+Michael+T&rft.aulast=Celi&rft.aufirst=Francesco&rft.date=2008-06-01&rft.volume=93&rft.issue=6&rft.spage=2383&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Etiology; toxicosis; Cyclic AMP; Transcription; Triiodothyronine; Promoters; McCune-Albright syndrome; Thyroxine; thyroid diseases; Iodide peroxidase; Mutation; Ultrasound; Signal transduction ER - TY - JOUR T1 - Risk adapted combined modality treatment in children with Hodgkin's disease: NCI, Cairo. AN - 733656370; 20029465 AB - The objective of this study is to maximize the chance of cure while minimizing surgery, radiotherapy and chemotherapy as much as possible to avoid late effects and toxicity of combined modality treatment in children with Hodgkin's disease. One hundred twenty-one (121) children under the age of 18 years with a histopathologic diagnosis of Hodgkin's disease were enrolled into this study. Patients were stratified according to stage into 3 risk groups: low (Stages: I, II A), intermediate (Stages: II B, III A) and high risk group (Stages: III B, IV). Oral Etoposide was used in this study instead of procarbazine in the management of boys with HD to reduce the gonadotoxic effects of procarbazine. Two cycles of OPPA for females and E-OPA for males were effective induction treatment for children with all stages of HD and stage-tailored chemotherapy (2, 4, 6 cycles of OPPA, E-OPA/ COPP) was sufficient to eradicate occult microfoci. Involved field radiotherapy was given in doses of 30, 25, 20 Gy, depending on the extent of initial chemotherapy and risk status. Staging laparotomy was performed in 30 patients out of the 121 patients, 24 of them underwent splenectomy. Patients who received whole neck radiotherapy were submitted to thyroid U/S and thyroid hormonal profile. Only 3 adolescent patients did semen analysis. The overall and disease-free survival rates at 6 years were 95.3% and 86.1% (95% CI), respectively (entire group), 96.1% , 92.3% (95% CI) for low risk, 96.1% , 80.7% (95% CI) for intermediate risk and 93.3% , 80% (95% CI) for high risk patients. During the followup period all patients had normal thyroid functions. In children with HD, only low dose involved field radiotherapy with reduced doses is needed,if a risk-dependent chemotherapy is given. In this series the strategy of selective laparotomy and restrictive splenectomy is very useful in the context of combined modality treatment, in which laparotomy was omitted if both abdominal U/S and CT were negative. JF - Journal of the Egyptian National Cancer Institute AU - El-Badawy, Samy AU - Aboulnaga, Sherif AU - Abou Gabal, Amin AU - Mokhless, Abeer AU - Zamzam, Manal AU - Sidhom, Iman AU - Ebeid, Emad AU - Hussein, Hany AD - The Department of Radiotherapy, NCI, Cairo University. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 99 EP - 110 VL - 20 IS - 2 SN - 1110-0362, 1110-0362 KW - Index Medicus KW - Laparotomy KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Salvage Therapy KW - Prognosis KW - Child KW - Child, Preschool KW - Egypt KW - Survival Rate KW - Risk Factors KW - Radiotherapy Dosage KW - Treatment Outcome KW - Adolescent KW - Female KW - Male KW - Remission Induction KW - Hodgkin Disease -- radiotherapy KW - Hodgkin Disease -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Hodgkin Disease -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733656370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Risk+adapted+combined+modality+treatment+in+children+with+Hodgkin%27s+disease%3A+NCI%2C+Cairo.&rft.au=El-Badawy%2C+Samy%3BAboulnaga%2C+Sherif%3BAbou+Gabal%2C+Amin%3BMokhless%2C+Abeer%3BZamzam%2C+Manal%3BSidhom%2C+Iman%3BEbeid%2C+Emad%3BHussein%2C+Hany&rft.aulast=El-Badawy&rft.aufirst=Samy&rft.date=2008-06-01&rft.volume=20&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-25 N1 - Date created - 2009-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies. AN - 733621293; 19079736 AB - Overexpression of ATP-binding cassette (ABC) drug transporters that actively efflux a variety of amphipathic compounds can cause multidrug resistance (MDR) in cancer cells, which is a major obstacle in the success of cancer chemotherapy. The development of synthetic small molecule compounds or the identification of natural products that block ABC transporter-mediated efflux has been the conventional approach used to combat MDR. The strategy of using chemosensitizers, however, has not been successful in clinical cancer chemotherapy. Therefore, alternative approaches to identify or to synthesize compounds that can induce selective toxicity in cancer cells overexpressing one or more ABC transporters have been undertaken. This review summarizes the recent advances in identifying strategies to restore sensitivity to chemotherapeutics in multidrug resistant cancer cells. JF - Current molecular pharmacology AU - Wu, Chung-Pu AU - Calcagno, Anna Maria AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 93 EP - 105 VL - 1 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Drug Carriers KW - Index Medicus KW - Chemosensitizers KW - ATP-binding cassette transporters KW - Multidrug resistance KW - Collateral sensitivity KW - Modulators KW - Humans KW - RNA Interference KW - Antineoplastic Agents -- pharmacology KW - Antineoplastic Agents -- antagonists & inhibitors KW - ATP-Binding Cassette Transporters -- metabolism KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733621293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+molecular+pharmacology&rft.atitle=Reversal+of+ABC+drug+transporter-mediated+multidrug+resistance+in+cancer+cells%3A+evaluation+of+current+strategies.&rft.au=Wu%2C+Chung-Pu%3BCalcagno%2C+Anna+Maria%3BAmbudkar%2C+Suresh+V&rft.aulast=Wu&rft.aufirst=Chung-Pu&rft.date=2008-06-01&rft.volume=1&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Current+molecular+pharmacology&rft.issn=1874-4702&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-24 N1 - Date created - 2009-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2003 Jun 6;278(23):20645-51 [12668685] Br J Cancer. 2003 Jun 16;88(12):1963-70 [12799644] Cancer Res. 2003 Jun 15;63(12):3084-91 [12810633] Biochemistry. 2003 Oct 28;42(42):12163-73 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Biochem Pharmacol. 2005 Nov 15;70(10):1424-30 [16214115] Blood. 2005 Nov 15;106(10):3584-93 [16051742] Curr Drug Deliv. 2004 Jul;1(3):203-12 [16305384] Carcinogenesis. 2006 Jan;27(1):123-30 [16000399] Cancer Chemother Pharmacol. 2006 Feb;57(3):376-88 [16021489] Biochem Pharmacol. 2006 Feb 14;71(4):426-40 [16343446] Trends Pharmacol Sci. 2006 Jan;27(1):10-6 [16337280] Annu Rev Pharmacol Toxicol. 1996;36:107-29 [8725384] Biochem Pharmacol. 1996 Aug 23;52(4):635-42 [8759037] Mol Pharmacol. 1996 Oct;50(4):808-19 [8863825] Int J Cancer. 1996 Oct 9;68(2):245-50 [8900436] Biochem Pharmacol. 1996 Nov 22;52(10):1545-52 [8937469] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. AN - 71663526; 18439915 AB - Colon epithelial cells are critical for barrier function and contain a highly developed immune response. A previous study has shown hypoxia-inducible factor (HIF) as a critical regulator of barrier protection during colon epithelial injury. However, the role of HIF signaling in colon mucosal immunity is not known. With the use of cre/loxP technology, intestinal-specific disruption of von Hippel-Lindau tumor suppressor protein (Vhl), hypoxia-inducible factor (Hif)-1alpha, and aryl hydrocarbon nuclear translocator (Arnt) was generated. Colon inflammation was induced using a dextran sulfate sodium (DSS)-induced colitis model, and the mice were analyzed by histologic analysis, Western blot analysis, and quantitative polymerase chain reaction. In mice, colonic epithelium disruption of Vhl resulted in constitutive expression of HIF, which initiated an increase in inflammatory infiltrates and edema in the colon. These effects were ameliorated in mice by disruption of both Vhl and Arnt/Hif1beta (which inactivates HIF). In a DSS-induced colitis model, increased HIF expression correlated with more severe clinical symptoms and an increase in histologic damage, while disruption of both Vhl and Arnt in the colon epithelium inhibited these effects. Furthermore, colons with constitutive activation of HIF displayed increased expression of proinflammatory mediators that were synergistically potentiated following DSS administration and reduced by inhibition of the proinflammatory and direct HIF target gene macrophage migration inhibitory factor. The present study shows that a chronic increase in HIF signaling in the colon epithelial cells initiates a hyperinflammatory reaction that may have important implications in developing therapeutic strategies for inflammatory bowel disease. JF - Gastroenterology AU - Shah, Yatrik M AU - Ito, Shinji AU - Morimura, Keiichirou AU - Chen, Chi AU - Yim, Sun-Hee AU - Haase, Volker H AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 2036 EP - 48, 2048.e1-3 VL - 134 IS - 7 KW - 3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester KW - 0 KW - Arnt protein, mouse KW - Basic Helix-Loop-Helix Transcription Factors KW - Enzyme Inhibitors KW - Hif1a protein, mouse KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Inflammation Mediators KW - Isoxazoles KW - Macrophage Migration-Inhibitory Factors KW - endothelial PAS domain-containing protein 1 KW - Aryl Hydrocarbon Receptor Nuclear Translocator KW - 138391-32-9 KW - Dextran Sulfate KW - 9042-14-2 KW - Von Hippel-Lindau Tumor Suppressor Protein KW - EC 2.3.2.27 KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Intramolecular Oxidoreductases KW - EC 5.3.- KW - Mif protein, mouse KW - EC 5.3.2.1 KW - VHL protein, mouse KW - EC 6.3.2.- KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Integrases -- genetics KW - Von Hippel-Lindau Tumor Suppressor Protein -- genetics KW - Disease Models, Animal KW - Intestinal Mucosa -- metabolism KW - Mice KW - Mice, Transgenic KW - Von Hippel-Lindau Tumor Suppressor Protein -- metabolism KW - Inflammation Mediators -- metabolism KW - Aryl Hydrocarbon Receptor Nuclear Translocator -- genetics KW - Recombination, Genetic KW - Aryl Hydrocarbon Receptor Nuclear Translocator -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Gene Expression Regulation KW - Time Factors KW - Isoxazoles -- pharmacology KW - Macrophage Migration-Inhibitory Factors -- metabolism KW - Colitis -- immunology KW - Colon -- pathology KW - Macrophage Migration-Inhibitory Factors -- genetics KW - Colon -- drug effects KW - Colitis -- pathology KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Basic Helix-Loop-Helix Transcription Factors -- genetics KW - Colitis -- metabolism KW - Colon -- immunology KW - Colitis -- prevention & control KW - Macrophage Migration-Inhibitory Factors -- antagonists & inhibitors KW - Intramolecular Oxidoreductases -- genetics KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Intramolecular Oxidoreductases -- metabolism KW - Colon -- enzymology KW - Colon -- metabolism KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Intramolecular Oxidoreductases -- antagonists & inhibitors KW - Colitis -- chemically induced KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71663526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Hypoxia-inducible+factor+augments+experimental+colitis+through+an+MIF-dependent+inflammatory+signaling+cascade.&rft.au=Shah%2C+Yatrik+M%3BIto%2C+Shinji%3BMorimura%2C+Keiichirou%3BChen%2C+Chi%3BYim%2C+Sun-Hee%3BHaase%2C+Volker+H%3BGonzalez%2C+Frank+J&rft.aulast=Shah&rft.aufirst=Yatrik&rft.date=2008-06-01&rft.volume=134&rft.issue=7&rft.spage=2036&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2008.03.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-07 N1 - Date created - 2008-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int Rev Immunol. 2000;19(1):51-62 [10723677] Mol Cell Biol. 1992 Dec;12(12):5447-54 [1448077] Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1583-8 [11171994] Science. 2001 Apr 20;292(5516):464-8 [11292862] Science. 2001 Apr 20;292(5516):468-72 [11292861] J Exp Med. 2001 May 7;193(9):1027-34 [11342587] Nat Immunol. 2001 Nov;2(11):1061-6 [11668338] Nature. 2001 Nov 29;414(6863):550-4 [11734856] Cancer Res. 2002 Jun 15;62(12):3387-94 [12067980] Gastroenterology. 2002 Jul;123(1):256-70 [12105854] J Clin Invest. 2002 Oct;110(7):993-1002 [12370277] Cell. 2003 Mar 7;112(5):645-57 [12628185] Proc Natl Acad Sci U S A. 1993 May 1;90(9):4304-8 [8387214] J Biol Chem. 1993 Oct 15;268(29):21513-8 [8408001] Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4 [7539918] Nat Struct Biol. 1996 Mar;3(3):259-66 [8605628] Genes Dev. 1997 Jan 1;11(1):72-82 [9000051] Nature. 1997 Mar 27;386(6623):403-7 [9121557] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9102-7 [9256442] Genes Dev. 1998 Jan 15;12(2):149-62 [9436976] Blood. 1998 Oct 1;92(7):2260-8 [9746763] Genes Dev. 1998 Nov 1;12(21):3320-4 [9808618] Gut. 1998 Oct;43(4):512-8 [9824579] J Clin Invest. 1999 Mar;103(5):691-6 [10074486] Clin Exp Immunol. 2005 May;140(2):241-8 [15807847] Proc Am Thorac Soc. 2005;2(1):26-33 [16113466] Curr Mol Med. 2005 Sep;5(6):549-56 [16178766] J Biol Chem. 2005 Nov 4;280(44):36541-4 [16115897] Cancer Res. 2006 Jul 1;66(13):6683-91 [16818642] Biochem Biophys Res Commun. 2006 Sep 8;347(4):895-903 [16854377] Immunol Lett. 2006 Nov 15;107(2):148-54 [17049622] Curr Mol Med. 2006 Dec;6(8):883-93 [17168739] Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G657-66 [17095756] Chest. 2007 Feb;131(2):524-32 [17296657] J Clin Invest. 2007 Mar;117(3):514-21 [17332878] Nat Protoc. 2007;2(3):541-6 [17406617] Cancer Cell. 2007 Apr;11(4):335-47 [17418410] Ann Med. 2007;39(3):177-99 [17457716] J Clin Invest. 2007 Jul;117(7):1940-50 [17607366] Gastroenterology. 2008 Jan;134(1):145-55 [18166352] Gastroenterology. 2008 Jan;134(1):156-65 [18166353] Blood. 2008 Apr 1;111(7):3343-54 [18199827] Biochim Biophys Acta. 2003 Apr 15;1626(1-3):10-8 [12697324] Nat Med. 2003 Jun;9(6):677-84 [12778166] Mol Cell Biol. 2003 Oct;23(19):6739-49 [12972594] Nat Rev Cancer. 2003 Oct;3(10):721-32 [13130303] Mol Cell Biol. 2003 Dec;23(24):9361-74 [14645546] J Biol Chem. 2004 Apr 9;279(15):14871-8 [14744852] FASEB J. 2004 May;18(7):790-804 [15117884] Genesis. 2004 Jul;39(3):186-93 [15282745] Drug Discov Today. 2004 Aug 15;9(16):704-11 [15341784] J Clin Invest. 2004 Oct;114(8):1098-106 [15489957] Mol Endocrinol. 2000 Oct;14(10):1674-81 [11043581] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1053/j.gastro.2008.03.009 ER - TY - JOUR T1 - Enhanced exocytotic-like insertion of Orai1 into the plasma membrane upon intracellular Ca2+ store depletion. AN - 71655011; 18400989 AB - Ca+ release-activated Ca2+ (CRAC) channels are activated when free Ca2+ concentration in the intracellular stores is substantially reduced and mediate sustained Ca2+ entry. Recent studies have identified Orai1 as a CRAC channel subunit. Here we demonstrate that passive Ca2+ store depletion using the inhibitor of the sarcoendoplasmic reticulum Ca2+-ATPase, thapsigargin (TG), enhances the surface expression of Orai1, a process that depends on rises in cytosolic free Ca2+ concentration, as demonstrated in cells loaded with dimethyl BAPTA, an intracellular Ca2+ chelator that prevented TG-evoked cytosolic free Ca2+ concentration elevation. Similar results were observed with a low concentration of carbachol. Cleavage of the soluble N-ethylmaleimide-sensitive-factor attachment protein receptor, synaptosomal-assiciated protein-25 (SNAP-25), with botulinum neurotoxin A impaired TG-induced increase in the surface expression of Orai1. In addition, SNAP-25 cleaving by botulinum neurotoxin A reduces the maintenance but not the initial stages of store-operated Ca2+ entry. In aggregate, these findings demonstrate that store depletion enhances Orai1 plasma membrane expression in an exocytotic manner that involves SNAP-25, a process that contributes to store-dependent Ca2+ entry. JF - American journal of physiology. Cell physiology AU - Woodard, Geoffrey E AU - Salido, Ginés M AU - Rosado, Juan A AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - C1323 EP - C1331 VL - 294 IS - 6 SN - 0363-6143, 0363-6143 KW - Calcium Channels KW - 0 KW - Chelating Agents KW - Enzyme Inhibitors KW - ORAI1 Protein KW - ORAI1 protein, human KW - Synaptosomal-Associated Protein 25 KW - Egtazic Acid KW - 526U7A2651 KW - Thapsigargin KW - 67526-95-8 KW - Carbachol KW - 8Y164V895Y KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases KW - EC 3.6.3.8 KW - 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid KW - K22DDW77C0 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Egtazic Acid -- analogs & derivatives KW - HeLa Cells KW - Humans KW - Botulinum Toxins, Type A -- pharmacology KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases -- metabolism KW - Thapsigargin -- pharmacology KW - Chelating Agents -- pharmacology KW - Synaptosomal-Associated Protein 25 -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Up-Regulation KW - Time Factors KW - Carbachol -- pharmacology KW - Egtazic Acid -- pharmacology KW - Protein Transport KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases -- antagonists & inhibitors KW - Exocytosis -- drug effects KW - Calcium -- metabolism KW - Calcium Channels -- metabolism KW - Sarcoplasmic Reticulum -- metabolism KW - Sarcoplasmic Reticulum -- drug effects KW - Cell Membrane -- drug effects KW - Sarcoplasmic Reticulum -- enzymology KW - Cell Membrane -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71655011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Cell+physiology&rft.atitle=Enhanced+exocytotic-like+insertion+of+Orai1+into+the+plasma+membrane+upon+intracellular+Ca2%2B+store+depletion.&rft.au=Woodard%2C+Geoffrey+E%3BSalido%2C+Gin%C3%A9s+M%3BRosado%2C+Juan+A&rft.aulast=Woodard&rft.aufirst=Geoffrey&rft.date=2008-06-01&rft.volume=294&rft.issue=6&rft.spage=C1323&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Cell+physiology&rft.issn=03636143&rft_id=info:doi/10.1152%2Fajpcell.00071.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-17 N1 - Date created - 2008-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/ajpcell.00071.2008 ER - TY - JOUR T1 - Effect of low-dose oral contraceptives on metabolic risk factors in African-American women. AN - 71654021; 18334585 AB - The effect of oral contraceptive pill (OCP) use on cardiovascular risk in African-American women is unknown. Our objective was to examine in African-American women the effect of OCP use on insulin resistance, glucose intolerance, and triglycerides (TGs). This was a cross-sectional study. The study was conducted at the National Institutes of Health Clinical Research Center. A total of 104 healthy nondiabetic African-American women [21 OCP users, 83 controls, age mean +/- sd, 34.7 +/- 7.6 yr, body mass index (BMI) 31 +/- 8.4 kg/m(2)] was included in the study. Subjects had oral glucose tolerance tests, insulin-modified frequently sampled iv glucose tolerance tests, and fasting lipid profiles. Insulin resistance was determined by the insulin sensitivity index (S(I)). Insulin resistance, glucose tolerance status, and TG levels were determined. Fasting glucose did not differ between OCP users and controls (P = 0.27). In contrast, compared with controls, 2-h glucose (135 +/- 23 vs.120 +/- 25 mg/dl; P = 0.01) and fasting TGs (73 +/- 31 vs.57 +/- 27 mg/dl; P = 0.02) were higher in OCP users. OCP users tended to be more insulin resistant than controls (S(I): 2.51 +/- 2.01 vs. 3.46 +/- 2.09; P = 0.09). Multiple regression analysis revealed that BMI, age, and OCP use were significant determinants of 2-h glucose (adjusted R(2) = 0.37; P < 0.001) and TG levels (adjusted R(2) = 0.21; P < 0.001). As BMI was a determinant of both 2-h glucose and TGs, participants were divided into nonobese and obese groups, and the analyses repeated. Among the nonobese women, the OCP users were more insulin resistant (S(I): 2.91 +/- 1.58 vs. 4.35 +/- 1.88; P = 0.03) and had a higher prevalence of glucose intolerance than controls (odds ratio 5.7; 95% confidence interval 1.4-24; P = 0.01). In African-American women, OCP use is associated with an increase in markers of cardiovascular risk manifested by increased insulin resistance, glucose intolerance, and elevated TGs. JF - The Journal of clinical endocrinology and metabolism AU - Frempong, Barbara A AU - Ricks, Madia AU - Sen, Sabyasachi AU - Sumner, Anne E AD - Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 2097 EP - 2103 VL - 93 IS - 6 SN - 0021-972X, 0021-972X KW - Contraceptives, Oral KW - 0 KW - Hormones KW - Lipids KW - Abridged Index Medicus KW - Index Medicus KW - Lipids -- blood KW - Cardiovascular Diseases -- etiology KW - Glucose Intolerance -- etiology KW - Humans KW - Hormones -- blood KW - Obesity -- complications KW - Obesity -- blood KW - Cross-Sectional Studies KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Insulin Resistance KW - Female KW - Contraceptives, Oral -- adverse effects KW - Metabolic Syndrome X -- etiology KW - African Americans KW - Contraceptives, Oral -- therapeutic use KW - Metabolic Syndrome X -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71654021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Effect+of+low-dose+oral+contraceptives+on+metabolic+risk+factors+in+African-American+women.&rft.au=Frempong%2C+Barbara+A%3BRicks%2C+Madia%3BSen%2C+Sabyasachi%3BSumner%2C+Anne+E&rft.aulast=Frempong&rft.aufirst=Barbara&rft.date=2008-06-01&rft.volume=93&rft.issue=6&rft.spage=2097&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/10.1210%2Fjc.2007-2599 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-17 N1 - Date created - 2008-06-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Diabetes Technol Ther. 2003;5(6):1003-15 [14709204] N Engl J Med. 2003 Aug 7;349(6):523-34 [12904517] J Clin Endocrinol Metab. 1981 Jan;52(1):29-33 [7451643] Contraception. 1984 Sep;30(3):197-208 [6509976] J Chronic Dis. 1987;40(1):3-11 [3805231] Int J Epidemiol. 1987 Jun;16(2):215-21 [3301706] Am J Obstet Gynecol. 1990 Jul;163(1 Pt 2):382-7 [2196809] J Reprod Med. 1991 Mar;36(3 Suppl):226-37 [2046076] J Clin Endocrinol Metab. 1992 Jan;74(1):64-70 [1530790] Endocrinol Metab Clin North Am. 1991 Dec;20(4):911-23 [1778182] Am J Obstet Gynecol. 1992 Jun;166(6 Pt 2):1955-63 [1605285] Diabete Metab. 1992 Mar-Apr;18(2):71-7 [1511755] Am J Obstet Gynecol. 1992 Oct;167(4 Pt 2):1177-84 [1415443] Diabetes. 1993 Nov;42(11):1663-72 [8405710] Clin Endocrinol (Oxf). 1994 Feb;40(2):249-55 [8137525] J Clin Endocrinol Metab. 1994 Nov;79(5):1277-83 [7962320] JAMA. 1995 Jan 18;273(3):199-208 [7807658] J Cardiovasc Risk. 1996 Apr;3(2):213-9 [8836866] Ann Intern Med. 1998 Mar 15;128(6):467-77 [9499331] JAMA. 1998 Aug 19;280(7):605-13 [9718051] Diabetes Care. 1999 Feb;22(2):233-40 [10333939] Menopause. 1999 Summer;6(2):147-55 [10374222] Adv Data. 2004 Dec 10;(350):1-36 [15633582] Arch Intern Med. 2005 Jun 27;165(12):1395-400 [15983289] J Clin Endocrinol Metab. 2005 Jul;90(7):3863-70 [15814774] Diabetes Care. 2006 Jun;29(6):1263-8 [16732006] Mayo Clin Proc. 2006 Jul;81(7):949-54; quiz 955 [16835975] Diabetes. 2006 Dec;55(12):3529-35 [17130501] Circulation. 2007 Jan 30;115(4):450-8 [17190864] N Engl J Med. 2007 Mar 29;356(13):1304-16 [17387129] Contraception. 2007 May;75(5):344-54 [17434015] N Engl J Med. 2007 Jun 21;356(25):2591-602 [17582069] Atherosclerosis. 2008 Feb;196(2):696-703 [17254586] Arch Intern Med. 2001 Feb 12;161(3):397-405 [11176766] Circulation. 2001 Sep 4;104(10):1108-13 [11535564] Diabetes Care. 2001 Nov;24(11):1978-83 [11679468] Prev Med. 2001 Dec;33(6):668-73 [11716665] Dan Med Bull. 2002 Feb;49(1):43-60 [11894723] Diabetes Care. 2002 Aug;25(8):1351-7 [12145234] J Clin Endocrinol Metab. 1980 Feb;50(2):246-50 [6986393] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/jc.2007-2599 ER - TY - JOUR T1 - Protein kinase Calpha-induced derepression of the human luteinizing hormone receptor gene transcription through ERK-mediated release of HDAC1/Sin3A repressor complex from Sp1 sites. AN - 71649743; 18372343 AB - LH receptor (LHR) gene transcription is subject to repression/derepression through various modes and multiple effectors. Epigenetic silencing and activation of the LHR is achieved through coordinated regulation at both histone and DNA levels. The LHR gene is subject to repression by deacetylation and methylation at its promoter region, where a HDAC/mSin3A repressor complex is anchored at Sp1 sites. The present studies revealed that protein kinase C (PKC) alpha/ERK signaling is important for the activation of LHR promoter activity, and the increase of endogenous transcripts induced by phorbol-12-myristate-13-acetate (PMA) in HeLa cells. Whereas these effects were attributable to PKCalpha activity, the ERK pathway was the downstream effector in LHR activation. PMA caused a significant enhancement of Sp1 phosphorylation at serine residue (s), which was blocked by PKCalpha or ERK inhibition. The interaction of activated phosphorylated ERK with Sp1 and ERK's association with the LHR promoter points to Sp1 as a direct target of ERK. After Sp1 phosphorylation, the HDAC1/mSin3A repressor complex dissociated from Sp1 sites, histone 3 was acetylated, and transcription factor II B and RNA polymerase II were recruited. In addition, overexpression of a constitutively active PKCalpha (PKCalpha CA) strongly activated LHR transcription in MCF-7 cells (devoid of PKCalpha), induced Sp1 phosphorylation at serine residue (s) and caused derecruitment of HDAC1/mSin3A complex from the promoter. These effects were negated by cotransfection of a dominant-negative PKCalpha. In conclusion, these studies have revealed a novel regulatory signaling mechanism of transcriptional control in which the LHR is derepressed through PKCalpha/ERK-mediated Sp1 phosphorylation, causing the release of HDAC1/mSin3A complex from the promoter. JF - Molecular endocrinology (Baltimore, Md.) AU - Liao, Mingjuan AU - Zhang, Ying AU - Dufau, Maria L AD - Program in Developmental Endocrinology and Genetics, National Institutes of Health, Bethesda, Maryland 20892-4510, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1449 EP - 1463 VL - 22 IS - 6 SN - 0888-8809, 0888-8809 KW - Multiprotein Complexes KW - 0 KW - Receptors, LH KW - Repressor Proteins KW - SIN3A transcription factor KW - Sp1 Transcription Factor KW - Protein Kinase C-alpha KW - EC 2.7.11.13 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - HDAC1 protein, human KW - EC 3.5.1.98 KW - Histone Deacetylase 1 KW - Histone Deacetylases KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Transcription, Genetic -- drug effects KW - Tumor Cells, Cultured KW - Promoter Regions, Genetic -- drug effects KW - Phosphorylation KW - HeLa Cells KW - Humans KW - Sp1 Transcription Factor -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Protein Binding KW - Multiprotein Complexes -- metabolism KW - Binding Sites KW - Protein Kinase C-alpha -- metabolism KW - Repressor Proteins -- metabolism KW - Receptors, LH -- genetics KW - Histone Deacetylases -- metabolism KW - Protein Kinase C-alpha -- physiology KW - Gene Expression Regulation KW - Extracellular Signal-Regulated MAP Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71649743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Protein+kinase+Calpha-induced+derepression+of+the+human+luteinizing+hormone+receptor+gene+transcription+through+ERK-mediated+release+of+HDAC1%2FSin3A+repressor+complex+from+Sp1+sites.&rft.au=Liao%2C+Mingjuan%3BZhang%2C+Ying%3BDufau%2C+Maria+L&rft.aulast=Liao&rft.aufirst=Mingjuan&rft.date=2008-06-01&rft.volume=22&rft.issue=6&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/10.1210%2Fme.2008-0035 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-26 N1 - Date created - 2008-05-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1999 Feb;19(2):1313-24 [9891065] Mol Cell Biol. 1999 Aug;19(8):5504-11 [10409740] Cancer Res. 1999 Sep 1;59(17):4266-70 [10485470] Biochem Biophys Res Commun. 1999 Sep 24;263(2):366-71 [10491299] Gene. 2005 Mar 28;348:1-11 [15777659] J Biomed Sci. 2005;12(2):289-96 [15917995] J Biol Chem. 2005 Jul 29;280(30):28061-71 [15878880] Trends Endocrinol Metab. 2005 Sep;16(7):320-6 [16054836] Mol Cell Biol. 2005 Sep;25(18):7929-39 [16135786] Mol Hum Reprod. 2005 Nov;11(11):837-42 [16364974] Biochim Biophys Acta. 2006 May-Jun;1761(5-6):542-51 [16574477] Mol Cell Biol. 2006 Sep;26(18):6748-61 [16943418] Clin Cancer Res. 2006 Sep 15;12(18):5336-45 [17000666] J Exp Ther Oncol. 2003 May-Jun;3(3):115-26 [14641818] N Engl J Med. 1999 Dec 2;341(23):1731-6 [10580072] J Biol Chem. 1999 Dec 10;274(50):35381-7 [10585406] J Biol Chem. 2000 Jan 28;275(4):2763-70 [10644740] Genes Cells. 2000 Jan;5(1):29-41 [10651903] Endocrinology. 2000 Oct;141(10):3611-22 [11014215] Oncogene. 2000 Nov 23;19(50):5712-9 [11126357] Biochem Biophys Res Commun. 2001 May 4;283(2):303-7 [11327698] EMBO J. 2001 Oct 15;20(20):5737-47 [11598016] Mol Endocrinol. 2001 Nov;15(11):1891-905 [11682620] J Biol Chem. 2001 Nov 9;276(45):42084-90 [11551946] Biol Reprod. 2002 Mar;66(3):813-22 [11870090] EMBO J. 2002 May 15;21(10):2451-60 [12006497] J Biol Chem. 2002 May 31;277(22):19618-26 [11919195] J Biol Chem. 2002 Jun 7;277(23):20631-9 [11904305] J Biol Chem. 2002 Jul 26;277(30):26761-8 [12004059] Endocrinology. 2002 Sep;143(9):3414-26 [12193554] Biochem Biophys Res Commun. 2002 Aug 30;296(4):1005-12 [12200149] J Biol Chem. 2002 Sep 6;277(36):32775-80 [12087091] J Biol Chem. 2002 Sep 6;277(36):33431-8 [12091390] J Biochem. 2002 Nov;132(5):669-75 [12417014] Oncogene. 2003 Feb 20;22(7):955-63 [12592382] Genome Biol. 2003;4(2):206 [12620113] Biochem J. 2003 Jun 15;372(Pt 3):787-97 [12628005] Mol Cell Biol. 2003 Oct;23(19):6958-72 [12972613] Cardiovasc Res. 2003 Oct 1;59(4):934-44 [14553833] Endocrinology. 1991 Nov;129(5):2486-90 [1657576] Nature. 1992 Jul 30;358(6385):414-7 [1322499] Endocr Rev. 1992 Aug;13(3):476-98 [1425484] J Biol Chem. 1993 Feb 25;268(6):4447-52 [8440726] Cell. 1993 Apr 23;73(2):381-93 [8386592] Endocrinology. 1993 Nov;133(5):2127-32 [8404662] Nature. 1993 Sep 30;365(6445):462-4 [8003102] Biochim Biophys Acta. 1993 Nov 24;1179(3):260-70 [8218370] Mol Cell Biol. 1994 Mar;14(3):1582-93 [8114696] J Biol Chem. 1994 Jun 3;269(22):15868-75 [8195242] Int J Cancer. 1994 Oct 1;59(1):83-93 [7927909] Mol Cell Biol. 1995 Oct;15(10):5444-52 [7565695] J Biol Chem. 1995 Dec 1;270(48):28495-8 [7499357] J Cell Sci. 2004 Jan 15;117(Pt 2):131-2 [14676268] Science. 2004 Jan 30;303(5658):682-4 [14726596] J Clin Endocrinol Metab. 1983 Oct;57(4):872-4 [6885969] Biochem J. 1983 Aug 15;214(2):569-74 [6311189] Biol Reprod. 1986 Nov;35(4):863-72 [3814700] Cell. 1990 Oct 5;63(1):155-65 [2170018] Exp Cell Res. 1995 Dec;221(2):377-84 [7493637] J Biol Chem. 1996 Jan 12;271(2):901-6 [8557703] Mol Cell Biol. 1996 Apr;16(4):1668-75 [8657142] Rev Reprod. 1996 Sep;1(3):193-202 [9414457] J Clin Endocrinol Metab. 1998 Jan;83(1):288-91 [9435458] Mol Cell Biol. 1998 Feb;18(2):790-8 [9447975] J Virol. 1998 Apr;72(4):2615-29 [9525578] Annu Rev Physiol. 1998;60:461-96 [9558473] Endocrinology. 1999 Jan;140(1):358-64 [9886846] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/me.2008-0035 ER - TY - JOUR T1 - Misoprostol for treatment of early pregnancy failure in women with previous uterine surgery. AN - 71648051; 18279821 AB - Misoprostol use in early pregnancy may incur a risk of uterine rupture in women with previous uterine surgery. We analyzed 488 women who received misoprostol 800 microg vaginally in a study that evaluated medical and surgical management of early pregnancy failure. Subjects received a repeat misoprostol dose if expulsion was not confirmed 2 days after treatment. We compared efficacy, acceptability, and safety in subjects with a history (n = 78 women) or absence (n = 410 women) of uterine surgery, defined as cesarean delivery or myomectomy. Expulsion rates after a single misoprostol dose (69% vs 72%; P = .64) and overall success at 30 days (82% vs 85%; P = .50) were comparable. Pain, bleeding, complications, and acceptability did not differ. No uterine ruptures occurred (95% CI, 0, 3.8%). Misoprostol treatment for early pregnancy failure had similar success, acceptability, and complications in women with and without previous uterine surgery. JF - American journal of obstetrics and gynecology AU - Chen, Beatrice A AU - Reeves, Matthew F AU - Creinin, Mitchell D AU - Gilles, Jerry M AU - Barnhart, Kurt AU - Westhoff, Carolyn AU - Zhang, Jun AU - National Institute of Child Health and Human Development Management of Early Pregnancy Failure Trial AD - Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, and Magee-Womens Research Institute, Pittsburgh, PA, USA. ; National Institute of Child Health and Human Development Management of Early Pregnancy Failure Trial Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 626.e1 EP - 5 VL - 198 IS - 6 KW - Oxytocics KW - 0 KW - Misoprostol KW - 0E43V0BB57 KW - Abridged Index Medicus KW - Index Medicus KW - Pregnancy Trimester, First KW - Humans KW - Adult KW - Administration, Intravaginal KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Uterine Rupture -- chemically induced KW - Misoprostol -- pharmacology KW - Uterus -- surgery KW - Oxytocics -- pharmacology KW - Misoprostol -- therapeutic use KW - Uterus -- drug effects KW - Oxytocics -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71648051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Misoprostol+for+treatment+of+early+pregnancy+failure+in+women+with+previous+uterine+surgery.&rft.au=Chen%2C+Beatrice+A%3BReeves%2C+Matthew+F%3BCreinin%2C+Mitchell+D%3BGilles%2C+Jerry+M%3BBarnhart%2C+Kurt%3BWesthoff%2C+Carolyn%3BZhang%2C+Jun%3BNational+Institute+of+Child+Health+and+Human+Development+Management+of+Early+Pregnancy+Failure+Trial&rft.aulast=Chen&rft.aufirst=Beatrice&rft.date=2008-06-01&rft.volume=198&rft.issue=6&rft.spage=626.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/10.1016%2Fj.ajog.2007.11.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-08 N1 - Date created - 2008-06-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Obstet Gynecol. 2006 Aug;108(2):465-8 [16880321] J Korean Med Sci. 2005 Dec;20(6):1079-81 [16361828] Isr J Med Sci. 1997 Nov;33(11):752-3 [9434814] Acta Obstet Gynecol Scand. 2000 May;79(5):431-2 [10830773] BJOG. 2000 Jun;107(6):807 [10847241] Int J Gynaecol Obstet. 2001 Mar;72(3):245-51 [11226445] J Am Assoc Gynecol Laparosc. 2001 Nov;8(4):618-21 [11677352] Reprod Contracept. 1999;10(4):227-33 [12349659] J Reprod Med. 2003 Jun;48(6):474-8 [12856524] J Obstet Gynaecol Res. 2003 Aug;29(4):251-6 [12959148] J Reprod Med. 2003 Sep;48(9):744-6 [14562644] J Obstet Gynaecol Res. 2004 Feb;30(1):34-6 [14718018] MMWR Morb Mortal Wkly Rep. 1993 Apr 23;42(15):285-9 [8479413] Am J Perinatol. 1995 Nov;12(6):439-41 [8579658] Obstet Gynecol. 1998 Feb;91(2):247-53 [9469284] N Engl J Med. 2005 Aug 25;353(8):761-9 [16120856] Reprod Toxicol. 2005 Nov-Dec;20(4):575-7 [15982851] Natl Vital Stat Rep. 2006 Sep 29;55(1):1-101 [17051727] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ajog.2007.11.045 ER - TY - JOUR T1 - Fractionated manganese-enhanced MRI. AN - 71633724; 17944008 AB - We investigated the use of manganese-enhanced MRI (MEMRI) with fractionated doses as a way to retain the unique properties of manganese as a neuronal contrast agent while lessening its toxic effects in animals. First, we followed the signal enhancement on T1-weighted images of the brains of rats receiving 30 mg/kg fractions of MnCl2 . 4H2O every 48 h and found that the signal increased in regions with consecutive fractionated doses and ultimately saturated. Second, we used T1 mapping to test whether the amount of MRI-visible manganese that accumulated depended on the concentration of manganese in the fractions. For a fixed cumulative dose of 180 mg/kg MnCl2 . 4H2O, increasing fraction doses of 6 x 30 mg/kg, 3 x 60 mg/kg, 2 x 90 mg/kg and 1 x 180 mg/kg produced progressively shorter T1 values. The adverse systemic health effects, including complications at the injection site and poor animal well-being, also rose with the fraction dose. Thus, fractionated MEMRI can be used to balance the properties of manganese as a contrast agent in animals against its toxic effects. JF - NMR in biomedicine AU - Bock, Nicholas A AU - Paiva, Fernando F AU - Silva, Afonso C AD - Cerebral Microcirculation Unit/Laboratory of Functional and Molecular Imaging/National Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, MD 20892-1065, USA. bockn@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 473 EP - 478 VL - 21 IS - 5 SN - 0952-3480, 0952-3480 KW - Chlorides KW - 0 KW - Contrast Media KW - Manganese Compounds KW - Manganese KW - 42Z2K6ZL8P KW - manganese chloride KW - QQE170PANO KW - Index Medicus KW - Rats KW - Chlorides -- toxicity KW - Animals KW - Drug Administration Schedule KW - Contrast Media -- pharmacokinetics KW - Manganese Compounds -- pharmacokinetics KW - Contrast Media -- toxicity KW - Chlorides -- pharmacokinetics KW - Male KW - Clinical Protocols KW - Radionuclide Imaging KW - Magnetic Resonance Imaging -- methods KW - Manganese -- pharmacokinetics KW - Brain -- diagnostic imaging KW - Manganese -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71633724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+biomedicine&rft.atitle=Fractionated+manganese-enhanced+MRI.&rft.au=Bock%2C+Nicholas+A%3BPaiva%2C+Fernando+F%3BSilva%2C+Afonso+C&rft.aulast=Bock&rft.aufirst=Nicholas&rft.date=2008-06-01&rft.volume=21&rft.issue=5&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=NMR+in+biomedicine&rft.issn=09523480&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Profiling of immune response to guide cancer diagnosis, prognosis, and prediction of therapy. AN - 71630104; 18519659 JF - Cancer research AU - Ambs, Stefan AU - Marincola, Francesco M AU - Thurin, Magdalena Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 4031 EP - 4033 VL - 68 IS - 11 KW - Biomarkers KW - 0 KW - Cytokines KW - Index Medicus KW - Cytokines -- blood KW - Genetic Variation KW - Disease-Free Survival KW - Humans KW - Prognosis KW - Reverse Transcriptase Polymerase Chain Reaction KW - Biomarkers -- blood KW - T-Lymphocytes -- immunology KW - Neoplasms -- diagnosis KW - Neoplasms -- pathology KW - Neoplasms -- therapy KW - Neoplasms -- genetics KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71630104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Cancer+research&rft.atitle=Profiling+of+immune+response+to+guide+cancer+diagnosis%2C+prognosis%2C+and+prediction+of+therapy.&rft.au=Ambs%2C+Stefan%3BMarincola%2C+Francesco+M%3BThurin%2C+Magdalena&rft.aulast=Ambs&rft.aufirst=Stefan&rft.date=2008-06-01&rft.volume=68&rft.issue=11&rft.spage=4031&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-0521 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-15 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-0521 ER - TY - JOUR T1 - Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer. AN - 71628475; 18506891 AB - Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. The clinical heterogeneity of HCC, and the lack of good diagnostic markers and treatment strategies, has rendered the disease a major challenge. Patients with HCC have a highly variable clinical course, indicating that HCC comprises several biologically distinctive subgroups reflecting a molecular heterogeneity of the tumors. Transforming growth factor beta (TGF-beta) is known to exhibit tumor stage dependent suppressive (that is, growth inhibition) and oncogenic (that is, invasiveness) properties. Here, we asked if a TGF-beta specific gene expression signature could refine the classification and prognostic predictions for HCC patients. Applying a comparative functional genomics approach we demonstrated that a temporal TGF-beta gene expression signature established in mouse primary hepatocytes successfully discriminated distinct subgroups of HCC. The TGF-beta positive cluster included two novel homogeneous groups of HCC associated with early and late TGF-beta signatures. Kaplan-Meier plots and log-rank statistics indicated that the patients with a late TGF-beta signature showed significantly (P < 0.005) shortened mean survival time (16.2 +/- 5.3 months) compared to the patients with an early (60.7 +/- 16.1 months) TGF-beta signature. Also, tumors expressing late TGF-beta-responsive genes displayed invasive phenotype and increased tumor recurrence. We also showed that the late TGF-beta signature accurately predicted liver metastasis and discriminated HCC cell lines by degree of invasiveness. Finally, we established that the TGF-beta gene expression signature possessed a predictive value for tumors other than HCC. These data demonstrate the clinical significance of the genes embedded in TGF-beta expression signature for the molecular classification of HCC. JF - Hepatology (Baltimore, Md.) AU - Coulouarn, Cédric AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 2059 EP - 2067 VL - 47 IS - 6 KW - Biomarkers, Tumor KW - 0 KW - Transforming Growth Factor beta KW - Index Medicus KW - Sensitivity and Specificity KW - Adenocarcinoma -- metabolism KW - Animals KW - Humans KW - Prognosis KW - Predictive Value of Tests KW - Mice KW - Adenocarcinoma -- genetics KW - Cell Line, Tumor KW - Mice, Knockout KW - Phenotype KW - Adenocarcinoma -- diagnosis KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Kaplan-Meier Estimate KW - Lung Neoplasms -- diagnosis KW - Cells, Cultured KW - Signal Transduction -- genetics KW - Neoplasm Recurrence, Local -- diagnosis KW - Lung Neoplasms -- genetics KW - Neoplasm Recurrence, Local -- genetics KW - Lung Neoplasms -- metabolism KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- diagnosis KW - Carcinoma, Hepatocellular -- genetics KW - Hepatocytes -- cytology KW - Transforming Growth Factor beta -- genetics KW - Transforming Growth Factor beta -- metabolism KW - Liver Neoplasms -- diagnosis KW - Gene Expression Profiling -- methods KW - Liver Neoplasms -- genetics KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71628475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Transforming+growth+factor-beta+gene+expression+signature+in+mouse+hepatocytes+predicts+clinical+outcome+in+human+cancer.&rft.au=Coulouarn%2C+C%C3%A9dric%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Coulouarn&rft.aufirst=C%C3%A9dric&rft.date=2008-06-01&rft.volume=47&rft.issue=6&rft.spage=2059&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.22283 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-03 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 2002 Dec;110(12):1831-8 [12488433] Blood. 2002 Jul 15;100(2):560-8 [12091349] Lancet. 2003 Dec 6;362(9399):1907-17 [14667750] Nat Rev Cancer. 2003 Nov;3(11):807-21 [14557817] Cancer Cell. 2004 Mar;5(3):215-9 [15050913] Hepatology. 2004 Sep;40(3):667-76 [15349906] Hepatology. 2004 Nov;40(5):1098-105 [15389868] Gastroenterology. 2004 Nov;127(5 Suppl 1):S27-34 [15508094] Gastroenterology. 2004 Nov;127(5 Suppl 1):S51-5 [15508103] J Clin Invest. 1996 Jan 15;97(2):388-95 [8567959] Cell. 1997 May 2;89(3):331-40 [9150132] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Gut. 2005 Aug;54(8):1162-8 [16009689] Nature. 2005 Jul 28;436(7050):518-24 [16049480] Oncogene. 2005 Oct 6;24(44):6617-25 [16007161] Genes Dev. 2005 Dec 1;19(23):2783-810 [16322555] Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):29-40 [16289860] Bioessays. 2006 Feb;28(2):169-81 [16435293] Hepatology. 2006 Feb;43(2 Suppl 1):S145-50 [16447291] Nat Rev Mol Cell Biol. 2006 Feb;7(2):131-42 [16493418] Nat Med. 2006 Apr;12(4):410-6 [16532004] J Clin Invest. 2006 Jun;116(6):1582-95 [16710476] Nat Rev Cancer. 2006 Jul;6(7):506-20 [16794634] Hepatology. 2006 Oct;44(4):1003-11 [17006931] Biochim Biophys Acta. 2007 Jan;1775(1):21-62 [16904831] Int J Cancer. 2007 Mar 15;120(6):1208-14 [17187364] Semin Liver Dis. 2007 Feb;27(1):55-76 [17295177] Genes Dev. 2001 Feb 15;15(4):455-66 [11230153] Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78 [11252892] Nat Genet. 2001 Oct;29(2):117-29 [11586292] Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13784-9 [11707590] Hepatology. 2002 May;35(5):1134-43 [11981763] Mol Biol Cell. 2002 Jun;13(6):1929-39 [12058060] Cell. 2003 Jun 13;113(6):685-700 [12809600] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.22283 ER - TY - JOUR T1 - Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. AN - 71627669; 18519758 AB - The organic anion transporter OATP1B3, encoded by SLCO1B3, is involved in the transport of steroid hormones. However, its role in testosterone uptake and clinical outcome of prostatic cancer is unknown. This study examined (a) the SLCO1B3 genotype in cancer cells as well as the uptake of testosterone by cells transfected with genetic variants of SLCO1B3; (b) the expression of OATP1B3 in normal prostate, benign prostatic hyperplasia, and prostatic cancer; and (c) the role of SLCO1B3 haplotype on clinical outcome of Caucasian patients with androgen-independent prostatic cancer. SLCO1B3 genotype was assessed in the NCI-60 panel of tumor cells by sequencing, whereas testosterone transport was analyzed in Cos-7 cells transfected with WT, 334G, and 699A SLCO1B3 variants. OATP1B3 expression in prostatic tissues was examined by fluorescence microscopy, and the relationship between SLCO1B3 haplotypes and survival was examined in patients. Cells transfected with wild-type (334T/699G) SLCO1B3, or with a vector containing either the 334G or 699A variants, actively transported testosterone, whereas its uptake was impaired in cells transfected with a gene carrying both 334G and 699A single nucleotide polymorphisms. Prostatic cancer overexpresses OATP1B3 compared with normal or benign hyperplastic tissue; patients with SLCO1B3 334GG/699AA haplotype showed longer median survival (8.5 versus 6.4 years; P = 0.020) and improved survival probability at 10 years (42% versus 23%; P < 0.023) than patients carrying TT/AA and TG/GA haplotypes. The common SLCO1B3 GG/AA haplotype is associated with impaired testosterone transport and improved survival in patients with prostatic cancer. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Hamada, Akinobu AU - Sissung, Tristan AU - Price, Douglas K AU - Danesi, Romano AU - Chau, Cindy H AU - Sharifi, Nima AU - Venzon, David AU - Maeda, Kenji AU - Nagao, Keisuke AU - Sparreboom, Alex AU - Mitsuya, Hiroaki AU - Dahut, William L AU - Figg, William D AD - Molecular Pharmacology Section, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 3312 EP - 3318 VL - 14 IS - 11 SN - 1078-0432, 1078-0432 KW - Organic Anion Transporters, Sodium-Independent KW - 0 KW - SLCO1B3 protein, human KW - Testosterone KW - 3XMK78S47O KW - Index Medicus KW - Animals KW - COS Cells KW - Humans KW - Aged KW - Mutagenesis, Site-Directed KW - Kaplan-Meier Estimate KW - Polymerase Chain Reaction KW - Haplotypes KW - Transfection KW - European Continental Ancestry Group KW - Adult KW - Cercopithecus aethiops KW - Middle Aged KW - Fluorescent Antibody Technique KW - Male KW - Prostatic Neoplasms -- metabolism KW - Organic Anion Transporters, Sodium-Independent -- genetics KW - Prostatic Neoplasms -- mortality KW - Testosterone -- metabolism KW - Prostatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71627669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Effect+of+SLCO1B3+haplotype+on+testosterone+transport+and+clinical+outcome+in+caucasian+patients+with+androgen-independent+prostatic+cancer.&rft.au=Hamada%2C+Akinobu%3BSissung%2C+Tristan%3BPrice%2C+Douglas+K%3BDanesi%2C+Romano%3BChau%2C+Cindy+H%3BSharifi%2C+Nima%3BVenzon%2C+David%3BMaeda%2C+Kenji%3BNagao%2C+Keisuke%3BSparreboom%2C+Alex%3BMitsuya%2C+Hiroaki%3BDahut%2C+William+L%3BFigg%2C+William+D&rft.aulast=Hamada&rft.aufirst=Akinobu&rft.date=2008-06-01&rft.volume=14&rft.issue=11&rft.spage=3312&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4118 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-28 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Res. 2001 Apr 1;61(7):2892-8 [11306464] J Urol. 2005 Mar;173(3):790-6 [15711271] Cancer Epidemiol Biomarkers Prev. 2001 Jul;10(7):743-8 [11440959] Clin Cancer Res. 2001 Jul;7(7):1888-93 [11448901] Endocr J. 2001 Oct;48(5):573-8 [11789562] Gastroenterology. 2002 May;122(5):1545-6; author reply 1546 [11984543] Cancer Epidemiol Biomarkers Prev. 2003 Feb;12(2):120-6 [12582021] Lab Invest. 2003 Apr;83(4):527-38 [12695556] World J Urol. 2004 Feb;21(6):414-23 [14648103] J Clin Oncol. 2004 Jul 1;22(13):2532-9 [15226321] Pharmacogenetics. 2004 Jul;14(7):441-52 [15226676] J Natl Cancer Inst. 1986 Jan;76(1):45-8 [3455741] Urology. 1989 May;33(5 Suppl):53-6 [2775378] Am J Physiol Gastrointest Liver Physiol. 2000 Jan;278(1):G156-64 [10644574] J Biol Chem. 2000 Jul 28;275(30):23161-8 [10779507] Biochim Biophys Acta. 2001 Mar 19;1518(1-2):73-8 [11267661] J Biol Chem. 2001 Mar 30;276(13):9626-30 [11134001] Mol Endocrinol. 1992 Dec;6(12):2229-35 [1491700] Am J Physiol. 1996 Feb;270(2 Pt 2):F332-7 [8779895] Cancer Chemother Pharmacol. 1996;39(1-2):1-8 [8995493] J Clin Oncol. 1997 Apr;15(4):1470-7 [9193342] Cancer Epidemiol Biomarkers Prev. 1997 Nov;6(11):967-9 [9367072] Clin Cancer Res. 1998 Jan;4(1):37-44 [9516950] J Urol. 2004 Nov;172(5 Pt 1):1848-52 [15540736] Prostate Cancer Prostatic Dis. 2004;7(4):333-7 [15477877] Anticancer Res. 2005 Mar-Apr;25(2B):1303-7 [15865082] Clin Cancer Res. 2005 Jul 1;11(13):4653-7 [16000557] JAMA. 2005 Jul 13;294(2):238-44 [16014598] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2173-7 [16172228] Am J Physiol Renal Physiol. 2006 Feb;290(2):F251-61 [16403838] Cancer Res. 2006 Mar 1;66(5):2815-25 [16510604] Cancer Lett. 2006 Mar 8;234(1):4-33 [16504381] Naunyn Schmiedebergs Arch Pharmacol. 2006 Mar;372(6):432-43 [16525793] J Clin Oncol. 2006 May 1;24(13):1982-9 [16648498] Drug Metab Pharmacokinet. 2006 Apr;21(2):165-9 [16702737] Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):429-45 [16863454] Clin Pharmacol Ther. 2007 Jan;81(1):76-82 [17186002] Curr Urol Rep. 2007 May;8(3):224-32 [17459272] Gastroenterology. 2001 Jun;120(7):1689-99 [11375950] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4118 ER - TY - JOUR T1 - Molecular genetics of successful smoking cessation: convergent genome-wide association study results. AN - 71627291; 18519826 AB - Smoking remains a major public health problem. Twin studies indicate that the ability to quit smoking is substantially heritable, with genetics that overlap modestly with the genetics of vulnerability to dependence on addictive substances. To identify replicated genes that facilitate smokers' abilities to achieve and sustain abstinence from smoking (herein after referred to as quit-success genes) found in more than 2 genome-wide association (GWA) studies of successful vs unsuccessful abstainers, and, secondarily, to nominate genes for selective involvement in smoking cessation success with bupropion hydrochloride vs nicotine replacement therapy (NRT). The GWA results in subjects from 3 centers, with secondary analyses of NRT vs bupropion responders. Outpatient smoking cessation trial participants from 3 centers. European American smokers who successfully vs unsuccessfully abstain from smoking with biochemical confirmation in a smoking cessation trial using NRT, bupropion, or placebo (N = 550). Quit-success genes, reproducibly identified by clustered nominally positive single-nucleotide polymorphisms (SNPs) in more than 2 independent samples with significant P values based on Monte Carlo simulation trials. The NRT-selective genes were nominated by clustered SNPs that display much larger t values for NRT vs placebo comparisons. The bupropion-selective genes were nominated by bupropion-selective results. Variants in quit-success genes are likely to alter cell adhesion, enzymatic, transcriptional, structural, and DNA, RNA, and/or protein-handling functions. Quit-success genes are identified by clustered nominally positive SNPs from more than 2 samples and are unlikely to represent chance observations (Monte Carlo P< .0003). These genes display modest overlap with genes identified in GWA studies of dependence on addictive substances and memory. These results support polygenic genetics for success in abstaining from smoking, overlap with genetics of substance dependence and memory, and nominate gene variants for selective influences on therapeutic responses to bupropion vs NRT. Molecular genetics should help match the types and/or intensity of antismoking treatments with the smokers most likely to benefit from them. JF - Archives of general psychiatry AU - Uhl, George R AU - Liu, Qing-Rong AU - Drgon, Tomas AU - Johnson, Catherine AU - Walther, Donna AU - Rose, Jed E AU - David, Sean P AU - Niaura, Ray AU - Lerman, Caryn AD - Molecular Neurobiology Research Branch, National Institutes of Health-Intramural Research Program, National Institute on Drug Abuse, 333 Cassell Dr, Ste 3510, Baltimore, MD 21224, USA. guhl@intra.nida.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 683 EP - 693 VL - 65 IS - 6 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Genetic Markers KW - Nicotinic Agonists KW - Bupropion KW - 01ZG3TPX31 KW - Nicotine KW - 6M3C89ZY6R KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Nicotine -- administration & dosage KW - Monte Carlo Method KW - Chromosome Mapping KW - Controlled Clinical Trials as Topic KW - Genetic Predisposition to Disease -- genetics KW - Adult KW - Antidepressive Agents, Second-Generation -- administration & dosage KW - Treatment Outcome KW - Nicotinic Agonists -- administration & dosage KW - Bupropion -- administration & dosage KW - Female KW - Male KW - Genetic Markers -- genetics KW - Alleles KW - Tobacco Use Disorder -- rehabilitation KW - Tobacco Use Disorder -- genetics KW - Smoking Cessation KW - Genetic Variation -- genetics KW - Smoking -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Genome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71627291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Molecular+genetics+of+successful+smoking+cessation%3A+convergent+genome-wide+association+study+results.&rft.au=Uhl%2C+George+R%3BLiu%2C+Qing-Rong%3BDrgon%2C+Tomas%3BJohnson%2C+Catherine%3BWalther%2C+Donna%3BRose%2C+Jed+E%3BDavid%2C+Sean+P%3BNiaura%2C+Ray%3BLerman%2C+Caryn&rft.aulast=Uhl&rft.aufirst=George&rft.date=2008-06-01&rft.volume=65&rft.issue=6&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=1538-3636&rft_id=info:doi/10.1001%2Farchpsyc.65.6.683 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2000 Apr;74(4):1489-97 [10737605] J Cardiovasc Pharmacol. 2005 May;45(5):418-30 [15821437] Am J Hum Genet. 2001 Dec;69(6):1290-300 [11704927] Biochemistry (Mosc). 2001 Oct;66(10):1174-86 [11736639] Nat Rev Genet. 2002 Nov;3(11):862-71 [12415316] Nicotine Tob Res. 2003 Apr;5(2):245-54 [12745498] Nicotine Tob Res. 2003 Feb;5(1):37-48 [12745505] Nat Neurosci. 2003 Jul;6(7):708-16 [12796785] J Neurosci. 2003 Jul 9;23(14):6005-12 [12853418] JAMA. 2004 Mar 10;291(10):1238-45 [15010446] Pharmacogenomics. 2005 Apr;6(3):211-23 [16013953] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9 [16091475] Neuroscience. 2005;135(3):863-8 [16154279] Brain Res Dev Brain Res. 2005 Nov 7;160(1):1-8 [16154207] Pharmacogenetics. 2004 Feb;14(2):83-90 [15077009] BMJ. 2004 Apr 24;328(7446):989-90 [15033882] Pharmacogenomics J. 2004;4(3):184-92 [15007373] Nitric Oxide. 2004 May;10(3):130-40 [15158692] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10308-13 [15210937] Mol Pharmacol. 2004 Sep;66(3):675-82 [15322260] Anal Biochem. 2004 Oct 1;333(1):72-8 [15351282] Control Clin Trials. 1990 Apr;11(2):116-28 [2161310] Acta Genet Med Gemellol (Roma). 1990;39(1):91-8 [2392895] J Subst Abuse. 1990;2(1):39-50 [2136102] J Clin Psychiatry. 1995 Sep;56(9):395-401 [7665537] Development. 1996 Oct;122(10):3163-71 [8898229] Addiction. 1997 Apr;92(4):469-72 [9177068] Hum Mol Genet. 1998 Feb;7(2):227-37 [9426258] Neuroreport. 1998 Aug 3;9(11):2485-8 [9721919] Exp Clin Psychopharmacol. 1998 Aug;6(3):331-43 [9725117] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] Hum Genomics. 2004 Nov;1(6):421-34 [15606997] Pharmacogenomics J. 2005;5(1):21-9 [15492764] Psychol Med. 2004 Oct;34(7):1251-61 [15697051] FASEB J. 2005 Apr;19(6):588-90 [15703273] Mol Cell Biol. 2005 Nov;25(22):10005-16 [16260614] Neuropsychopharmacology. 2006 Jan;31(1):231-42 [16123753] Hum Genomics. 2006 Mar;2(5):310-7 [16595075] Twin Res Hum Genet. 2006 Feb;9(1):64-72 [16611469] Cell. 2006 May 5;125(3):607-20 [16678102] NeuroRx. 2006 Jul;3(3):295-301 [16815213] Curr Biol. 2006 Aug 8;16(15):1524-30 [16890528] Behav Med. 2006 Summer;32(2):47-56 [16903614] Addiction. 2006 Sep;101 Suppl 1:23-30 [16930158] Expert Opin Emerg Drugs. 2006 Sep;11(3):429-44 [16939383] Science. 2006 Oct 20;314(5798):475-8 [17053149] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53 [16894614] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):918-25 [17099884] Hum Mol Genet. 2007 Jan 1;16(1):24-35 [17158188] BMC Genet. 2007;8:10 [17407593] Hum Mol Genet. 2007 Jun 1;16(11):1327-34 [17409192] Nature. 2007 Jun 7;447(7145):661-78 [17554300] Am J Hum Genet. 2007 Jul;81(1):17-31 [17564960] Nicotine Tob Res. 2007 Aug;9(8):821-33 [17654295] Pharmacogenomics J. 2007 Oct;7(5):353-61 [17224915] Am J Med Genet. 2000 Oct 9;96(5):665-70 [11054775] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archpsyc.65.6.683 ER - TY - JOUR T1 - Bone metabolism in pregnant women exposed to single compared with multiple courses of corticosteroids. AN - 71623450; 18515519 AB - To compare markers of maternal bone metabolism between women who received a single compared with multiple courses of antenatal corticosteroids. This is an analysis of serum samples from a previously reported randomized, placebo-controlled, multicenter trial. Women at risk for preterm delivery after an initial course of corticosteroids were randomly assigned to weekly courses of betamethasone (active) or placebo. Serum levels of carboxy terminal propeptide of type I procollagen (PICP) and cross-linked carboxy terminal telopeptide of type I collagen (ICTP) were measured to assess the rate of bone formation and resorption, respectively, at three time points. The placebo group (n=93) was compared with the active group, receiving four or more courses of betamethasone (n=112). There were significant (P<.001) increases in PICP and ICTP between baseline and delivery in both groups. Cross-linked carboxy terminal telopeptide of type I collagen, but not PICP, was lower with corticosteroid exposure immediately before administration of the fourth study course (P<.001). No significant differences in PICP and ICTP were seen between groups at delivery. Increasing levels of PICP and ICTP with advancing gestation are consistent with physiologic changes in maternal bone metabolism. Multiple courses of corticosteroids for fetal maturation are not associated with persistent or cumulative effects on maternal bone metabolism as measured by PICP and ICTP. II. JF - Obstetrics and gynecology AU - Carroll, Mary A AU - Vidaeff, Alex C AU - Mele, Lisa AU - Wapner, Ronald J AU - Mercer, Brian AU - Peaceman, Alan M AU - Sorokin, Yoram AU - Dudley, Donald J AU - Spong, Catherine Y AU - Leveno, Kenneth J AU - Harper, Margaret AU - Caritis, Steve N AU - Miodovnik, Menachem AU - Thorp, John M AU - Moawad, Atef AU - O'Sullivan, Mary J AU - Carpenter, Marshall W AU - Rouse, Dwight J AU - Sibai, Baha AU - National Institute of Child Health and Human Development (NICHD) Maternal Fetal Medicine Units Network (MFMU) AD - Department of Obstetrics and Gynecology, University of Texas Houston, Houston, Texas 77030, USA. ; National Institute of Child Health and Human Development (NICHD) Maternal Fetal Medicine Units Network (MFMU) Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1352 EP - 1358 VL - 111 IS - 6 SN - 0029-7844, 0029-7844 KW - Biomarkers KW - 0 KW - Collagen Type I KW - Glucocorticoids KW - Peptide Fragments KW - Peptides KW - Procollagen KW - collagen type I trimeric cross-linked peptide KW - procollagen type I carboxy terminal peptide KW - Betamethasone KW - 9842X06Q6M KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Obstetric Labor, Premature -- prevention & control KW - Female KW - Pregnancy KW - Peptides -- blood KW - Bone and Bones -- drug effects KW - Glucocorticoids -- administration & dosage KW - Procollagen -- blood KW - Betamethasone -- adverse effects KW - Glucocorticoids -- adverse effects KW - Betamethasone -- administration & dosage KW - Peptide Fragments -- blood KW - Bone and Bones -- metabolism KW - Collagen Type I -- blood KW - Biomarkers -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71623450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Bone+metabolism+in+pregnant+women+exposed+to+single+compared+with+multiple+courses+of+corticosteroids.&rft.au=Carroll%2C+Mary+A%3BVidaeff%2C+Alex+C%3BMele%2C+Lisa%3BWapner%2C+Ronald+J%3BMercer%2C+Brian%3BPeaceman%2C+Alan+M%3BSorokin%2C+Yoram%3BDudley%2C+Donald+J%3BSpong%2C+Catherine+Y%3BLeveno%2C+Kenneth+J%3BHarper%2C+Margaret%3BCaritis%2C+Steve+N%3BMiodovnik%2C+Menachem%3BThorp%2C+John+M%3BMoawad%2C+Atef%3BO%27Sullivan%2C+Mary+J%3BCarpenter%2C+Marshall+W%3BRouse%2C+Dwight+J%3BSibai%2C+Baha%3BNational+Institute+of+Child+Health+and+Human+Development+%28NICHD%29+Maternal+Fetal+Medicine+Units+Network+%28MFMU%29&rft.aulast=Carroll&rft.aufirst=Mary&rft.date=2008-06-01&rft.volume=111&rft.issue=6&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/10.1097%2FAOG.0b013e318173573b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-06-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Obstet Gynecol. 2006 Sep;195(3):633-42 [16846587] J Clin Endocrinol Metab. 1993 Jul;77(1):178-82 [8325940] JAMA. 1995 Feb 1;273(5):413-8 [7823388] J Bone Miner Res. 2000 Jan;15(1):129-37 [10646122] BJOG. 2000 Mar;107(3):434-5 [10740348] BJOG. 2000 Apr;107(4):577-8 [10759286] BJOG. 2000 Apr;107(4):578 [10759287] Obstet Gynecol. 2001 Jul;98(1):144-50 [11430973] JAMA. 2001 Oct 3;286(13):1581-7 [11585480] Am J Obstet Gynecol. 2001 Nov;185(5):1073-80 [11717636] Eur J Obstet Gynecol Reprod Biol. 2003 Feb 10;106(2):209-13 [12551794] Clin Obstet Gynecol. 2003 Mar;46(1):161-73 [12686905] Clin Chim Acta. 2003 Jul 1;333(1):1-11 [12809730] Pediatrics. 1972 Oct;50(4):515-25 [4561295] Am J Obstet Gynecol. 1981 Oct 1;141(3):276-87 [7025638] N Engl J Med. 1983 Aug 4;309(5):306-8 [6866054] Br J Obstet Gynaecol. 1990 Jan;97(1):11-25 [2137711] Clin Chem. 1990 Jul;36(7):1328-32 [2372946] Obstet Gynecol. 1991 Jun;77(6):841-5 [2030854] J Bone Miner Res. 1993 Feb;8(2):127-32 [8442431] Clin Chem. 1993 Apr;39(4):635-40 [8472358] Am J Clin Nutr. 1995 Mar;61(3):514-23 [7872214] Am J Obstet Gynecol. 1995 Jul;173(1):254-62 [7631700] J Clin Endocrinol Metab. 1996 Feb;81(2):752-6 [8636299] Br J Obstet Gynaecol. 1996 Jul;103(7):716-8 [8688403] Endocr Rev. 1997 Dec;18(6):832-72 [9408745] Clin Biochem. 1997 Dec;30(8):573-93 [9455610] Br J Obstet Gynaecol. 1998 May;105(5):551-5 [9637126] Br J Obstet Gynaecol. 1999 Sep;106(9):977-9 [10492112] Br J Obstet Gynaecol. 1999 Oct;106(10):1093-5 [10519438] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/AOG.0b013e318173573b ER - TY - JOUR T1 - A phase II study of biweekly paclitaxel (P) and gemcitabine (G), followed by maintenance weekly paclitaxel in elderly patients with advanced non-small cell lung cancer (NSCLC). AN - 71620591; 18068853 AB - This phase II study was conducted to evaluate the efficacy and safety of a novel combination of paclitaxel (P) and gemcitabine (G) in an every 2 weeks schedule followed by weekly paclitaxel (P) as first-line treatment in elderly patients with locally advanced or metastatic NSCLC. Elderly patients (> or =65 years of age) with 1997 TNM stage IIIB (pleural effusion)/stage IV NSCLC, performance status (PS) of 0-2 and normal organ function were eligible. Therapy consisted of P at 150 mg/m(2) and G at 2000 mg/m(2) administered every 2 weeks for 3 cycles followed, in progression-free patients, by P at 80 mg/m(2) every week for 6 consecutive weeks every 8 weeks for 2 cycles. Fifty-three eligible patients were enrolled: M/F 51/2; stage IIIB/IV 8/45; PS 0, 40%, PS 1 51%, PS 2 9%; median age, 73 years (range 67-82). The overall response rate was 32% (95% confidence interval [CI]: 19-45). The median overall survival was 7 months (95% CI: 5-9); the median progression-free survival was 5 months (95% CI: 3-6); and the 1- and 2-year survivals were 28.3% and 10.1%, respectively. Both phases of the treatment protocol were well tolerated. Biweekly P/G followed by weekly P is well tolerated and active as first-line therapy for elderly NSCLC patients. JF - Lung cancer (Amsterdam, Netherlands) AU - Pino, Maria Simona AU - Gamucci, Teresa AU - Mansueto, Giovanni AU - Trapasso, Tiziana AU - Narducci, Filomena AU - Giampaolo, Maria Anna AU - Fariello, Anna Maria AU - Sperduti, Isabella AU - Ceribelli, Anna AU - Cognetti, Francesco AD - Division of Medical Oncology A, Regina Elena National Cancer Institute, Via Chianesi 53, Rome 00144, Italy. pino@ifo.it Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 381 EP - 386 VL - 60 IS - 3 SN - 0169-5002, 0169-5002 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Kaplan-Meier Estimate KW - Drug Administration Schedule KW - Disease-Free Survival KW - Neoplasm Staging KW - Aged, 80 and over KW - Humans KW - Aged KW - Male KW - Female KW - Paclitaxel -- administration & dosage KW - Deoxycytidine -- analogs & derivatives KW - Lung Neoplasms -- drug therapy KW - Deoxycytidine -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71620591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.atitle=A+phase+II+study+of+biweekly+paclitaxel+%28P%29+and+gemcitabine+%28G%29%2C+followed+by+maintenance+weekly+paclitaxel+in+elderly+patients+with+advanced+non-small+cell+lung+cancer+%28NSCLC%29.&rft.au=Pino%2C+Maria+Simona%3BGamucci%2C+Teresa%3BMansueto%2C+Giovanni%3BTrapasso%2C+Tiziana%3BNarducci%2C+Filomena%3BGiampaolo%2C+Maria+Anna%3BFariello%2C+Anna+Maria%3BSperduti%2C+Isabella%3BCeribelli%2C+Anna%3BCognetti%2C+Francesco&rft.aulast=Pino&rft.aufirst=Maria&rft.date=2008-06-01&rft.volume=60&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.issn=01695002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-30 N1 - Date created - 2008-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of herbs and spices in cancer prevention. AN - 70796036; 18499033 AB - Historically, herbs and spices have enjoyed a rich tradition of use for their flavor enhancement characteristics and for their medicinal properties. The rising prevalence of chronic diseases worldwide and the corresponding rise in health care costs is propelling interest among researchers and the public for multiple health benefits related to these food items, including a reduction in cancer risk and modification of tumor behavior. A growing body of epidemiological and preclinical evidence points to culinary herbs and spices as minor dietary constituents with multiple anticancer characteristics. This review focuses on the antimicrobial, antioxidant, and antitumorigenic properties of herbs and spices; their ability to influence carcinogen bioactivation; and likely anticancer contributions. While culinary herbs and spices present intriguing possibilities for health promotion, more complete information is needed about the actual exposures to dietary components that are needed to bring about a response and the molecular target(s) for specific herbs and spices. Only after this information is obtained will it be possible to define appropriate intervention strategies to achieve maximum benefits from herbs and spices without eliciting ill consequences. JF - The Journal of nutritional biochemistry AU - Kaefer, Christine M AU - Milner, John A AD - Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 347 EP - 361 VL - 19 IS - 6 SN - 0955-2863, 0955-2863 KW - Anti-Infective Agents KW - 0 KW - Anticarcinogenic Agents KW - Antifungal Agents KW - Antioxidants KW - Carcinogens KW - Flavonoids KW - Terpenes KW - Index Medicus KW - Carcinogens -- metabolism KW - Antifungal Agents -- pharmacology KW - Antioxidants -- pharmacology KW - Biotransformation KW - Humans KW - Anti-Infective Agents -- pharmacology KW - Terpenes -- pharmacology KW - Flavonoids -- pharmacology KW - Inflammation -- complications KW - Anticarcinogenic Agents -- therapeutic use KW - Anticarcinogenic Agents -- pharmacology KW - Neoplasms -- prevention & control KW - Diet KW - Plants, Medicinal -- adverse effects KW - Spices -- adverse effects KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70796036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutritional+biochemistry&rft.atitle=The+role+of+herbs+and+spices+in+cancer+prevention.&rft.au=Kaefer%2C+Christine+M%3BMilner%2C+John+A&rft.aulast=Kaefer&rft.aufirst=Christine&rft.date=2008-06-01&rft.volume=19&rft.issue=6&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutritional+biochemistry&rft.issn=09552863&rft_id=info:doi/10.1016%2Fj.jnutbio.2007.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-07 N1 - Date created - 2008-05-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Nutr. 2006 Mar;136(3 Suppl):716S-725S [16484550] CA Cancer J Clin. 2006 Mar-Apr;56(2):69-83 [16514135] Phytother Res. 2006 Apr;20(4):239-49 [16557604] J Agric Food Chem. 2006 Apr 19;54(8):2891-6 [16608205] Biochem Pharmacol. 2006 May 14;71(10):1397-421 [16563357] Chem Res Toxicol. 2006 May;19(5):627-44 [16696565] Am J Clin Nutr. 2006 Jul;84(1):95-135 [16825686] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1555-8 [16896049] Int J Food Microbiol. 2006 Aug 15;111(1):6-11 [16797760] Mol Nutr Food Res. 2006 Nov;50(11):1030-8 [17039458] Environ Health Perspect. 2006 Nov;114(11):1797-801 [17107870] Free Radic Biol Med. 2006 Dec 15;41(12):1727-46 [17157175] Food Chem Toxicol. 2007 Mar;45(3):440-7 [17074427] Food Chem Toxicol. 2007 Aug;45(8):1437-42 [17524539] Life Sci. 2003 Nov 14;73(26):3427-37 [14572883] Nutr Cancer. 2003;47(2):171-80 [15087270] Natl Toxicol Program Tech Rep Ser. 2004 Feb;(514):1-281 [15146216] Curr Med Chem. 2004 Jun;11(11):1451-60 [15180577] J Agric Food Chem. 2004 Jun 16;52(12):4026-37 [15186133] Carcinogenesis. 2004 Sep;25(9):1671-9 [15073046] Int J Cancer. 1989 Oct 15;44(4):611-6 [2793233] Nutr Cancer. 1993;20(1):21-9 [8415127] Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2046-50 [7510883] J Biol Chem. 1995 Oct 20;270(42):24995-5000 [7559628] Cancer Lett. 1995 Sep 4;96(1):23-9 [7553604] Eur J Cancer Prev. 1997 Dec;6(6):522-8 [9496453] Cancer Lett. 1998 Mar 13;125(1-2):199-207 [9566716] Q Rev Biol. 1998 Mar;73(1):3-49 [9586227] J Nutr Biochem. 2007 Sep;18(9):567-79 [17360173] Acta Pharmacol Sin. 2007 Sep;28(9):1274-304 [17723163] J Nutr. 2003 Oct;133(10):3248S-3254S [14519822] Food Chem Toxicol. 1999 Sep-Oct;37(9-10):937-42 [10541448] Phytother Res. 1999 Nov;13(7):616-8 [10548758] Nutr Cancer. 1999;35(2):120-6 [10693164] Ann Clin Lab Sci. 2000 Apr;30(2):145-58 [10807157] J Nutr. 2000 Sep;130(9):2243-50 [10958819] Lancet. 2001 Feb 17;357(9255):539-45 [11229684] J Nutr. 2001 Mar;131(3s):1106S-8S [11238826] FEBS Lett. 2001 May 4;496(1):12-8 [11343698] Food Chem Toxicol. 2001 Sep;39(9):907-18 [11498267] J Cell Biochem. 2001;82(4):537-48 [11500931] Mutat Res. 2001 Sep 1;480-481:179-88 [11506812] Helicobacter. 2001 Sep;6(3):249-53 [11683929] J Agric Food Chem. 2001 Nov;49(11):5165-70 [11714298] J Korean Med Sci. 2001 Dec;16 Suppl:S38-41 [11748375] Exp Biol Med (Maywood). 2002 Jan;227(1):20-5 [11788779] Food Chem Toxicol. 2002 Aug;40(8):1051-62 [12067564] J Am Diet Assoc. 2002 Aug;102(8):1105-18 [12171455] Biochem J. 2002 Sep 15;366(Pt 3):901-10 [12069687] Gastroenterology. 2002 Oct;123(4):985-91 [12360458] J Am Diet Assoc. 2002 Oct;102(10):1414-20 [12396158] Lett Appl Microbiol. 2003;36(3):162-7 [12581376] Drug Metab Rev. 2003 Feb;35(1):35-98 [12635815] J Nutr. 2003 May;133(5):1286-90 [12730411] Cancer Res. 2003 Aug 1;63(15):4375-83 [12907607] Lung Cancer. 2003 Sep;41(3):269-81 [12928118] Am J Clin Nutr. 2003 Sep;78(3 Suppl):559S-569S [12936950] J Clin Pathol. 2003 Sep;56(9):651-3 [12944546] Antimicrob Agents Chemother. 2003 Oct;47(10):3240-6 [14506036] Clin Chem. 1998 Jun;44(6 Pt 1):1309-15 [9625058] Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5292-7 [10220459] Indian J Gastroenterol. 1999 Jul-Sep;18(3):118-21 [10407566] Int J Antimicrob Agents. 1999 Aug;12(3):257-62 [10461845] Clin Microbiol Rev. 1999 Oct;12(4):564-82 [10515903] Biofactors. 2004;21(1-4):27-31 [15630166] Eur J Immunol. 2005 Feb;35(2):584-92 [15668926] Br J Nutr. 2005 Feb;93(2):257-66 [15788119] FEMS Immunol Med Microbiol. 2005 May 1;44(2):197-204 [15866216] Cancer Lett. 2005 Jun 8;223(2):181-90 [15896452] J Assoc Physicians India. 2004 Oct;52:794-804 [15909857] Mutat Res. 2005 Jul 4;584(1-2):1-256 [15979392] J Agric Food Chem. 2005 Oct 5;53(20):7749-59 [16190627] Dig Dis Sci. 2005 Nov;50(11):2191-3 [16240238] Yonsei Med J. 2005 Oct 31;46(5):585-96 [16259055] Mutat Res. 2005 Dec 11;591(1-2):123-46 [16102784] J Nutr. 2005 Dec;135(12 Suppl):2993S-3001S [16317160] Mol Cancer Ther. 2006 Jan;5(1):39-51 [16432161] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jnutbio.2007.11.003 ER - TY - JOUR T1 - Limitations of using a single postdose midazolam concentration to predict CYP3A-mediated drug interactions. AN - 70793140; 18420532 AB - Midazolam is a common probe used to predict CYP3A activity, but multiple blood samples are necessary to determine midazolam's area under the concentration-time curve (AUC). As such, single sampling strategies have been examined. The purpose of this study was to assess the ability of single midazolam concentrations to predict midazolam AUC in the presence and absence of CYP3A modulation by Ginkgo biloba extract (GBE). Subjects received oral midazolam 8 mg before and after 28 days of GBE administration. Postdose blood samples were collected during both study periods and midazolam AUC determined. Linear regression was used to generate measures of predictive performance for each midazolam concentration. The geometric mean ratio (90% confidence intervals) of midazolam AUC(0-infinity) post-GBE/AUC(0-infinity) pre-GBE was 0.66 (0.49-0.84) (P = .03). Before and after GBE administration, optimal midazolam sampling times were identified at 3.5 to 5 hours and 2 to 3 hours, respectively. Single midazolam concentrations between 2 and 5 hours correctly predicted the reduction in midazolam AUC following GBE exposure, but confidence intervals were generally wide. Intersubject variability in CYP3A activity (either inherent or from drug administration) alters the prediction of optimal midazolam sampling times; therefore, midazolam AUC is preferred for assessing CYP3A activity in drug-drug interaction studies. JF - Journal of clinical pharmacology AU - Penzak, Scott R AU - Busse, Kristin H AU - Robertson, Sarah M AU - Formentini, Elizabeth AU - Alfaro, Raul M AU - Davey, Richard T AD - Clinical Pharmacokinetics Research Laboratory, National Institutes of Health, Clinical Center Pharmacy Department, Bldg 10, Room 1N 257, Bethesda, MD 20892, USA. spenzak@mail.cc.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 671 EP - 680 VL - 48 IS - 6 SN - 0091-2700, 0091-2700 KW - Plant Extracts KW - 0 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Midazolam KW - R60L0SM5BC KW - Index Medicus KW - Administration, Oral KW - Forecasting -- methods KW - Area Under Curve KW - Humans KW - Linear Models KW - Adult KW - Middle Aged KW - Longitudinal Studies KW - Ginkgo biloba -- chemistry KW - Time Factors KW - Male KW - Female KW - Plant Extracts -- pharmacology KW - Midazolam -- pharmacokinetics KW - Cytochrome P-450 CYP3A -- metabolism KW - Herb-Drug Interactions KW - Cytochrome P-450 CYP3A -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70793140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=Limitations+of+using+a+single+postdose+midazolam+concentration+to+predict+CYP3A-mediated+drug+interactions.&rft.au=Penzak%2C+Scott+R%3BBusse%2C+Kristin+H%3BRobertson%2C+Sarah+M%3BFormentini%2C+Elizabeth%3BAlfaro%2C+Raul+M%3BDavey%2C+Richard+T&rft.aulast=Penzak&rft.aufirst=Scott&rft.date=2008-06-01&rft.volume=48&rft.issue=6&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270008317305 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacokinet Biopharm. 1981 Aug;9(4):503-12 [7310648] J Clin Pharmacol. 1986 Jan;26(1):55-9 [2936766] Clin Pharmacol Ther. 2005 Nov;78(5):529-39 [16321619] Eur J Clin Pharmacol. 2006 Aug;62(8):653-9 [16832678] Clin Pharmacol Ther. 2007 Oct;82(4):379; author reply 380 [17851579] Clin Pharmacol Ther. 1981 Nov;30(5):653-61 [6117393] Pharmacogenetics. 2000 Apr;10(3):187-216 [10803676] Pharmacogenetics. 2001 Dec;11(9):781-91 [11740342] J Clin Pharmacol. 2002 Apr;42(4):376-82 [11936561] J Clin Pharmacol. 2002 Oct;42(10):1079-82 [12362920] Eur J Clin Pharmacol. 2004 Jun;60(4):237-46 [15114429] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0091270008317305 ER - TY - JOUR T1 - Phase II study of dose-adjusted EPOCH and rituximab in untreated diffuse large B-cell lymphoma with analysis of germinal center and post-germinal center biomarkers. AN - 70791684; 18378569 AB - To assess the clinical outcome and the influence of biomarkers associated with apoptosis inhibition (Bcl-2), tumor proliferation (MIB-1), and cellular differentiation on the outcome with dose-adjusted (DA) EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) plus rituximab (R) infusional therapy in diffuse large B-cell lymphoma (DLBCL) with analysis of germinal center B-cell (GCB) and post-GCB subtypes by immunohistochemistry. Phase II study of 72 patients with untreated de novo DLBCL who were at least 18 years of age and stage II or higher. Radiation consolidation was not permitted. Patients had a median age of 50 years (range, 19 to 85) and 40% had a high-intermediate or high International Prognostic Index (IPI). At 5 years, progression-free survival (PFS) and overall survival (OS) were 79% and 80%, respectively, with a median potential follow-up of 54 months. PFS was 91%, 90%, 67%, and 47%, and OS was 100%, 90%, 74%, and 37%, for 0 to 1, 2, 3, and 4 to 5 IPI factors, respectively, at 5 years. The Bcl-2 and MIB-1 biomarkers were not associated with PFS or OS. Based on DA-EPOCH historical controls, rituximab only benefited Bcl-2 positive tumors. Bcl-6 expression was associated with higher PFS whereas GCB exhibited a marginally significant higher PFS compared with post-GCB DLBCL. DA-EPOCH-R outcome was not affected by tumor proliferation and rituximab appeared to overcome the adverse effect of Bcl-2. Bcl-6 may identify a biologic program associated with a superior outcome. Overall, DA-EPOCH-R shows promising outcome in low and intermediate IPI groups. A molecular model of treatment outcome with rituximab and chemotherapy is presented. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Wilson, Wyndham H AU - Dunleavy, Kieron AU - Pittaluga, Stefania AU - Hegde, Upendra AU - Grant, Nicole AU - Steinberg, Seth M AU - Raffeld, Mark AU - Gutierrez, Martin AU - Chabner, Bruce A AU - Staudt, Louis AU - Jaffe, Elaine S AU - Janik, John E AD - Metabolism Branch, National Cancer Institute, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA. wilsonw@mail.nih.gov Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 2717 EP - 2724 VL - 26 IS - 16 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Murine-Derived KW - Antineoplastic Agents KW - Biomarkers, Tumor KW - Rituximab KW - 4F4X42SYQ6 KW - Vincristine KW - 5J49Q6B70F KW - Etoposide KW - 6PLQ3CP4P3 KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Humans KW - Prednisone -- therapeutic use KW - Etoposide -- therapeutic use KW - Prognosis KW - Aged KW - Kaplan-Meier Estimate KW - Cyclophosphamide -- therapeutic use KW - Vincristine -- therapeutic use KW - Aged, 80 and over KW - Adult KW - Doxorubicin -- therapeutic use KW - Middle Aged KW - Immunohistochemistry KW - Lymphoma, Large B-Cell, Diffuse -- mortality KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - Lymphoma, Large B-Cell, Diffuse -- pathology KW - Biomarkers, Tumor -- classification KW - Antibodies, Monoclonal -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Germinal Center -- drug effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70791684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+II+study+of+dose-adjusted+EPOCH+and+rituximab+in+untreated+diffuse+large+B-cell+lymphoma+with+analysis+of+germinal+center+and+post-germinal+center+biomarkers.&rft.au=Wilson%2C+Wyndham+H%3BDunleavy%2C+Kieron%3BPittaluga%2C+Stefania%3BHegde%2C+Upendra%3BGrant%2C+Nicole%3BSteinberg%2C+Seth+M%3BRaffeld%2C+Mark%3BGutierrez%2C+Martin%3BChabner%2C+Bruce+A%3BStaudt%2C+Louis%3BJaffe%2C+Elaine+S%3BJanik%2C+John+E&rft.aulast=Wilson&rft.aufirst=Wyndham&rft.date=2008-06-01&rft.volume=26&rft.issue=16&rft.spage=2717&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2007.13.1391 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-25 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 1990 Oct;62(4):551-2 [2223571] Cancer Chemother Rep. 1966 Mar;50(3):163-70 [5910392] N Engl J Med. 1993 Sep 30;329(14):987-94 [8141877] Blood. 1994 Mar 15;83(6):1460-6 [8123837] Blood. 1997 Jan 15;89(2):601-9 [9002964] Cancer Chemother Rep. 1964 Feb;35:1-111 [14117037] Nature. 2004 Dec 2;432(7017):635-9 [15577913] J Clin Oncol. 2005 Jun 20;23(18):4117-26 [15867204] J Clin Oncol. 2005 Aug 1;23(22):5027-33 [15955905] Histopathology. 2005 Sep;47(3):281-91 [16115229] Nat Immunol. 2005 Oct;6(10):1054-60 [16142238] Leuk Lymphoma. 2005 Nov;46(11):1569-73 [16236611] Haematologica. 2006 Apr;91(4):496-502 [16537117] Lancet Oncol. 2006 May;7(5):379-91 [16648042] Haematologica. 2006 May;91(5):715-6 [16670080] Blood. 2006 Jun 1;107(11):4207-13 [16449523] J Clin Oncol. 2006 Jul 1;24(19):3121-7 [16754935] Semin Hematol. 2006 Oct;43(4):230-9 [17027657] Blood. 2007 Jan 15;109(2):843-4; discussion 844-5 [17210865] Br J Haematol. 2007 Jan;136(2):276-85 [17233819] J Clin Oncol. 2007 Feb 10;25(5):579-86 [17242396] Blood. 2007 Mar 1;109(5):1857-61 [17105812] J Clin Oncol. 2007 Mar 1;25(7):805-12 [17327602] Blood. 2007 Apr 1;109(7):2759-66 [17132720] Blood. 2007 Jun 1;109(11):4930-5 [17299093] Oncogene. 2007 May 28;26(25):3629-36 [17530016] Blood. 2007 Jul 1;110(1):339-44 [17379744] Nat Immunol. 2007 Jul;8(7):705-14 [17558410] J Clin Oncol. 1999 Apr;17(4):1244 [10561185] Nature. 2000 Feb 3;403(6769):503-11 [10676951] J Exp Med. 2001 Dec 17;194(12):1861-74 [11748286] Biochem Biophys Res Commun. 2001 Dec 21;289(5):1199-204 [11741320] N Engl J Med. 2002 Jan 24;346(4):235-42 [11807147] Blood. 2002 Apr 15;99(8):2685-93 [11929754] N Engl J Med. 2002 Jun 20;346(25):1937-47 [12075054] Blood. 2003 Jun 1;101(11):4279-84 [12576316] J Exp Med. 2003 Sep 15;198(6):851-62 [12975453] Blood. 2004 Jan 1;103(1):275-82 [14504078] Mol Cancer Ther. 2004 May;3(5):621-32 [15141020] Am J Pathol. 2004 Jul;165(1):159-66 [15215171] N Engl J Med. 1993 Apr 8;328(14):1002-6 [7680764] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2007.13.1391 ER - TY - JOUR T1 - The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole. AN - 70779960; 18436267 AB - Allosteric modulation of ligand-gated ion channels can play important roles in shaping synaptic transmission. The function of the 5-hydroxytryptamine (serotonin) type 3 (5-HT(3)) receptor, a member of the Cys-loop ligand-gated ion channel superfamily, is modulated by a variety of compounds such as alcohols, anesthetics and 5-hydroxyindole (5-HI). In this study, the molecular determinants of allosteric modulation by 5-HI were explored in N1E-115 neuroblastoma cells expressing the native 5-HT(3) receptor and HEK 293 cells transfected with the recombinant 5-HT(3A) receptor using molecular biology and whole-cell patch-clamp techniques. 5-HI potentiated 5-HT-activated currents in both N1E-115 cells and HEK 293 cells, and significantly decreased current desensitization and deactivation. Substitution of Leu293 (L293, L15') in the second transmembrane domain (TM2) with cysteine (L293C) or serine (L293S) abolished 5-HI modulation. Other mutations in the TM2 domain, such as D298A and T284F, failed to alter 5-HI modulation. The L293S mutation enhanced dopamine efficacy and converted 5-HI into a partial agonist at the mutant receptor. These data suggest that 5-HI stabilizes the 5-HT(3A) receptor in the open state by decreasing both desensitization and 5-HT unbinding/channel closing; and L293 is a common site for both channel gating and allosteric modulation by 5-HI. Our observations also indicate existence of a second 5-HI recognition site on the 5-HT(3A) receptor, which may overlap with the 5-HT binding site and is not involved in the positive modulation by 5-HI. These findings support the idea that there are two discrete sites for 5-HI allosteric modulation and direct activation in the 5-HT(3A) receptor. JF - Neuropharmacology AU - Hu, Xiang-Qun AU - Lovinger, David M AD - Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-8115, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1153 EP - 1165 VL - 54 IS - 8 SN - 0028-3908, 0028-3908 KW - Amino Acids KW - 0 KW - Indoles KW - Ligands KW - Receptors, Serotonin, 5-HT3 KW - Serotonin Receptor Agonists KW - 5-hydroxyindole KW - 320UN7XZYN KW - Serotonin KW - 333DO1RDJY KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Serotonin -- pharmacology KW - Humans KW - Amino Acids -- analysis KW - Amino Acid Sequence KW - Ion Channel Gating -- drug effects KW - Mutagenesis, Site-Directed KW - Patch-Clamp Techniques KW - Cells, Cultured KW - Kinetics KW - Signal Transduction -- drug effects KW - Molecular Sequence Data KW - Point Mutation KW - Data Interpretation, Statistical KW - Receptors, Serotonin, 5-HT3 -- metabolism KW - Indoles -- pharmacology KW - Receptors, Serotonin, 5-HT3 -- genetics KW - Receptors, Serotonin, 5-HT3 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70779960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=The+L293+residue+in+transmembrane+domain+2+of+the+5-HT3A+receptor+is+a+molecular+determinant+of+allosteric+modulation+by+5-hydroxyindole.&rft.au=Hu%2C+Xiang-Qun%3BLovinger%2C+David+M&rft.aulast=Hu&rft.aufirst=Xiang-Qun&rft.date=2008-06-01&rft.volume=54&rft.issue=8&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.03.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-25 N1 - Date created - 2008-05-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2007 Nov 28;27(48):13151-60 [18045909] J Physiol. 2006 Aug 1;574(Pt 3):699-710 [16690715] J Neurosci. 1999 Dec 1;19(23):10213-20 [10575018] J Gen Physiol. 2000 May;115(5):637-51 [10779320] J Gen Physiol. 2000 Sep;116(3):327-40 [10962011] Neurosci Lett. 2001 Jun 1;305(1):77-80 [11356312] J Biol Chem. 2001 Nov 9;276(45):42035-42 [11557761] Nat Rev Neurosci. 2002 Feb;3(2):102-14 [11836518] Neuropharmacology. 2002 Sep;43(3):374-84 [12243767] J Neurosci. 2002 Oct 1;22(19):8411-21 [12351715] J Biol Chem. 2002 Nov 29;277(48):46256-64 [12368287] Br J Pharmacol. 2003 Jan;138(1):245-53 [12522096] Nature. 2003 Jun 26;423(6943):949-55 [12827192] J Biol Chem. 2003 Nov 21;278(47):46583-9 [12970351] J Neurosci. 2002 Mar 1;22(5):1629-39 [11880493] Mol Membr Biol. 2002 Jan-Mar;19(1):11-26 [11989819] Pharmacol Rev. 2002 Jun;54(2):323-74 [12037145] Biochem Soc Trans. 2004 Jun;32(Pt3):535-9 [15157179] J Neurosci. 2004 Jun 16;24(24):5537-48 [15201326] Mol Pharmacol. 2004 Jul;66(1):169-77 [15213309] Neuropharmacology. 1988 Mar;27(3):301-7 [3374770] Neuron. 1989 Mar;2(3):1195-205 [2483110] Br J Pharmacol. 1993 Feb;108(2):287-9 [7680589] Eur J Pharmacol. 1993 Apr 15;245(2):187-92 [7683998] Br J Pharmacol. 1994 Jun;112(2):541-6 [8075873] Trends Neurosci. 1995 Mar;18(3):121-7 [7754520] Mol Pharmacol. 1995 Sep;48(3):379-84 [7565616] Br J Pharmacol. 1996 Mar;117(5):839-46 [8851499] Neuropharmacology. 1997 Apr-May;36(4-5):649-53 [9225290] Trends Pharmacol Sci. 1997 Nov;18(11):425-9 [9426470] J Physiol. 1998 Mar 1;507 ( Pt 2):335-52 [9518697] Proc Natl Acad Sci U S A. 1998 May 26;95(11):6504-9 [9600996] Br J Pharmacol. 1998 Nov;125(5):924-47 [9846630] Nat Neurosci. 1999 Mar;2(3):219-25 [10195213] J Physiol. 1999 Sep 15;519 Pt 3:713-22 [10457085] Neuropharmacology. 1999 Aug;38(8):1083-152 [10462127] J Neurosci. 2005 Aug 31;25(35):8056-65 [16135763] J Physiol. 2005 Oct 15;568(Pt 2):381-96 [16096341] Nature. 2005 Nov 10;438(7065):248-52 [16281040] Br J Pharmacol. 2006 May;148(1):88-101 [16520747] Nature. 1997 Sep 25;389(6649):385-9 [9311780] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2008.03.009 ER - TY - JOUR T1 - IL-15 acts as a potent inducer of CD4(+)CD25(hi) cells expressing FOXP3. AN - 70778977; 18493981 AB - IL-15 is a member of the gamma chain-dependent cytokines and known to affect innate and CD8(+) adaptive immune responses. Despite a growing interest in the use of IL-15 as an immunotherapeutic agent, the broad spectrum of immunoregulatory functions exerted by IL-15 has not been fully elucidated. Here, we demonstrate that IL-15 increases expression of CD25 and forkhead box transcription factor P3 (FOXP3), a master transcriptional regulator of regulatory T cells, in human peripheral CD4(+)CD25(-) T cells in the absence of antigenic stimulation. Comparisons involving IL-2 and IL-7 revealed that the induction of CD25(hi) and FOXP3 expression was most prominent with IL-15 and IL-2. More modest effects were seen with IL-7. Despite levels of FOXP3 expression comparable to that of conventional regulatory T cells, cytokine-induced CD4(+)CD25(hi)FOXP3(+) cells exerted only weak suppressor activity. Thus, the current study has demonstrated that IL-15 acts as a potent inducer of CD4(+)CD25(hi)FOXP3(+) cells in the periphery, and suggests a potential role for IL-15 in blunting immune activation. This study has provided further insights into the pleiotropic nature of IL-15 beyond the regulation of CD8(+) T cells. JF - European journal of immunology AU - Imamichi, Hiromi AU - Sereti, Irini AU - Lane, H Clifford AD - Laboratory of Molecular Retrovirology, Clinical Services Program, SAIC-Frederick Inc, NCI-Frederick, Frederick, MD 21702, USA. himamichi@nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1621 EP - 1630 VL - 38 IS - 6 SN - 0014-2980, 0014-2980 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD27 KW - Antigens, CD28 KW - Antigens, CD3 KW - FOXP3 protein, human KW - Forkhead Transcription Factors KW - Interleukin-15 KW - Interleukin-2 KW - Interleukin-2 Receptor alpha Subunit KW - Interleukin-7 KW - Ionomycin KW - 56092-81-0 KW - Interferon-gamma KW - 82115-62-6 KW - Antigens, CD45 KW - EC 3.1.3.48 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Gene Expression -- drug effects KW - Cell Proliferation -- drug effects KW - Interleukin-2 -- pharmacology KW - Antigens, CD27 -- analysis KW - CD8-Positive T-Lymphocytes -- drug effects KW - Interleukin-2 -- metabolism KW - CD8-Positive T-Lymphocytes -- metabolism KW - Humans KW - Ionomycin -- pharmacology KW - Antibodies, Monoclonal -- pharmacology KW - Reverse Transcriptase Polymerase Chain Reaction KW - CD4-Positive T-Lymphocytes -- drug effects KW - Interleukin-7 -- pharmacology KW - Antibodies, Monoclonal -- immunology KW - Lymphocyte Activation -- drug effects KW - Antigens, CD3 -- immunology KW - Blotting, Western KW - CD4-Positive T-Lymphocytes -- metabolism KW - Antigens, CD45 -- analysis KW - Interferon-gamma -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Flow Cytometry KW - Antigens, CD28 -- immunology KW - Interleukin-2 Receptor alpha Subunit -- metabolism KW - Forkhead Transcription Factors -- genetics KW - T-Lymphocytes, Regulatory -- drug effects KW - Interleukin-15 -- pharmacology KW - Forkhead Transcription Factors -- metabolism KW - Cell Differentiation -- drug effects KW - T-Lymphocytes, Regulatory -- metabolism KW - T-Lymphocytes, Regulatory -- immunology KW - Cell Differentiation -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70778977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+immunology&rft.atitle=IL-15+acts+as+a+potent+inducer+of+CD4%28%2B%29CD25%28hi%29+cells+expressing+FOXP3.&rft.au=Imamichi%2C+Hiromi%3BSereti%2C+Irini%3BLane%2C+H+Clifford&rft.aulast=Imamichi&rft.aufirst=Hiromi&rft.date=2008-06-01&rft.volume=38&rft.issue=6&rft.spage=1621&rft.isbn=&rft.btitle=&rft.title=European+journal+of+immunology&rft.issn=00142980&rft_id=info:doi/10.1002%2Feji.200737607 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-18 N1 - Date created - 2008-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer J Sci Am. 2000 Feb;6 Suppl 1:S2-7 [10685650] J Exp Med. 1994 Nov 1;180(5):1955-60 [7964471] Clin Immunol. 2000 Dec;97(3):266-76 [11112366] J Exp Med. 2001 Jun 4;193(11):1285-94 [11390435] J Exp Med. 2001 Jun 4;193(11):1303-10 [11390437] Eur J Immunol. 2001 May;31(5):1351-60 [11465092] Nat Immunol. 2001 Sep;2(9):816-22 [11526392] Nat Rev Immunol. 2002 Jun;2(6):389-400 [12093005] Immunity. 2002 Aug;17(2):167-78 [12196288] Science. 2003 Feb 14;299(5609):1057-61 [12522256] Nat Immunol. 2003 Apr;4(4):330-6 [12612578] Nat Immunol. 2003 Apr;4(4):337-42 [12612581] Immunology. 2003 Jul;109(3):319-25 [12807474] J Clin Oncol. 2003 Aug 15;21(16):3127-32 [12915604] J Clin Invest. 2003 Nov;112(9):1437-43 [14597769] J Immunol. 2003 Dec 15;171(12):6323-7 [14662827] J Exp Med. 2003 Dec 15;198(12):1875-86 [14676299] Immunol Cell Biol. 2004 Feb;82(1):67-74 [14984597] Arthritis Res Ther. 2004;6(4):174-7 [15225362] Int Immunol. 2004 Nov;16(11):1643-56 [15466453] Science. 1976 Sep 10;193(4257):1007-8 [181845] J Exp Med. 1984 Nov 1;160(5):1390-403 [6092510] J Immunol. 1993 Sep 1;151(5):2426-35 [7689607] Cell. 1993 Oct 22;75(2):253-61 [8402910] Science. 1994 May 13;264(5161):965-8 [8178155] Proc Natl Acad Sci U S A. 1994 May 24;91(11):4935-9 [8197160] Int Immunol. 2007 Apr;19(4):345-54 [17329235] N Engl J Med. 1995 Mar 2;332(9):567-75 [7646637] J Exp Med. 1995 Apr 1;181(4):1519-26 [7699333] Science. 1995 Jun 9;268(5216):1472-6 [7770771] Immunity. 1995 Oct;3(4):521-30 [7584142] J Interferon Cytokine Res. 1995 Mar;15(3):269-76 [7584674] N Engl J Med. 1996 Oct 31;335(18):1350-6 [8857018] J Immunol. 1998 Aug 15;161(4):1875-82 [9712056] Immunity. 1998 Nov;9(5):669-76 [9846488] J Infect Dis. 1999 Apr;179(4):849-58 [10068580] Immunol Rev. 2004 Dec;202:67-83 [15546386] Nat Immunol. 2005 Apr;6(4):345-52 [15785760] J Virol. 2005 Apr;79(8):4877-85 [15795273] J Clin Invest. 2005 Jul;115(7):1839-47 [15937547] J Clin Invest. 2005 Aug;115(8):2139-48 [16025158] Nat Immunol. 2005 Nov;6(11):1142-51 [16227984] J Clin Invest. 2005 Nov;115(11):3276-84 [16211090] Annu Rev Immunol. 2006;24:209-26 [16551248] Annu Rev Immunol. 2006;24:657-79 [16551262] Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6659-64 [16617117] J Immunother. 2006 May-Jun;29(3):313-9 [16699374] J Clin Invest. 2006 Jun;116(6):1514-24 [16691294] J Immunol. 2007 Jan 1;178(1):280-90 [17182565] Eur J Immunol. 2007 Jan;37(1):129-38 [17154262] J Clin Oncol. 1999 Jul;17(7):2105-16 [10561265] Eur J Immunol. 2007 Jan;37(1):21-3 [17183612] Clin Immunol. 2007 Apr;123(1):18-29 [17185041] J Exp Med. 2000 Mar 6;191(5):771-80 [10704459] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/eji.200737607 ER - TY - JOUR T1 - Validation of gefitinib effectiveness in a broad panel of head and neck squamous carcinoma cells. AN - 70777062; 18506376 AB - Recently improved understanding of the pathogenesis of human head and neck squamous cell carcinoma (HNSCC) has led to the development of new, molecular-based therapeutic strategies, one of the more promising is the utilisation of tyrosine kinase (TK) inhibitors, targeting epidermal growth factor receptor (EGFR). In this study, we tested for gefitinib effectiveness in a broad panel of 12 newly established HNSCC cell lines, investigating its ability to reduce cell growth, to induce apoptosis and to modulate cell cycle and various EGFR pathway-related targets. Gefitinib IC50 values ranged between 0.064 and 33 microM, its capability to induce apoptosis and cell accumulation in G0/G1 phase was cell line-specific, and the main EGFR-related pathway involved in gefitinib activity was PI3K/Akt/mTor. We characterised our in vitro panel extensively, with the aim to identify predictive factors for gefitinib effectiveness; all cell lines were free of human papillomavirus infection, two were positive for Fhit expression, four expressed wild-type p53, and all of them variously expressed the other two p53 family members, p63 and p73. The comparison between the targets analysed and gefitinib effectiveness evidenced the absence of a clear relationship, excluding them as predictive factors for gefitinib efficacy. Our results confirmed the in vitro efficacy of an anti-EGFR approach, but other targets than those analysed here should be characterised in order to identify valid predictive factors for gefitinib utilisation. JF - International journal of molecular medicine AU - Sebastian, S AU - Azzariti, A AU - Accardi, R AU - Conti, D AU - Pilato, B AU - LaCalamita, R AU - Porcelli, L AU - Simone, G M AU - Tommasi, S AU - Tommasino, M AU - Paradiso, A AD - Clinical Experimental Oncology Laboratory, National Cancer Institute, Bari, Italy. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 809 EP - 817 VL - 21 IS - 6 SN - 1107-3756, 1107-3756 KW - CKAP4 protein, human KW - 0 KW - DNA-Binding Proteins KW - Membrane Proteins KW - Neoplasm Proteins KW - Nuclear Proteins KW - Protein Kinase Inhibitors KW - Quinazolines KW - Tumor Protein p73 KW - Tumor Suppressor Protein p53 KW - Tumor Suppressor Proteins KW - fragile histidine triad protein KW - p73 protein, human KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Acid Anhydride Hydrolases KW - EC 3.6.- KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- genetics KW - Nuclear Proteins -- genetics KW - Humans KW - Tumor Suppressor Proteins -- genetics KW - DNA-Binding Proteins -- genetics KW - Head and Neck Neoplasms -- pathology KW - Acid Anhydride Hydrolases -- metabolism KW - Membrane Proteins -- genetics KW - Tumor Cells, Cultured KW - Carcinoma, Squamous Cell -- pathology KW - Tumor Suppressor Proteins -- metabolism KW - Apoptosis -- drug effects KW - Neoplasm Proteins -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Inhibitory Concentration 50 KW - Tumor Suppressor Protein p53 -- genetics KW - Head and Neck Neoplasms -- genetics KW - Acid Anhydride Hydrolases -- genetics KW - Nuclear Proteins -- metabolism KW - Resting Phase, Cell Cycle -- drug effects KW - Neoplasm Proteins -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Membrane Proteins -- metabolism KW - Immunoprecipitation KW - Carcinoma, Squamous Cell -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Tumor Suppressor Protein p53 -- metabolism KW - Blotting, Western KW - Head and Neck Neoplasms -- metabolism KW - G1 Phase -- drug effects KW - Mutation KW - Cell Cycle -- drug effects KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Receptor, Epidermal Growth Factor -- metabolism KW - Receptor, Epidermal Growth Factor -- genetics KW - Protein Kinase Inhibitors -- pharmacology KW - Quinazolines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70777062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+molecular+medicine&rft.atitle=Validation+of+gefitinib+effectiveness+in+a+broad+panel+of+head+and+neck+squamous+carcinoma+cells.&rft.au=Sebastian%2C+S%3BAzzariti%2C+A%3BAccardi%2C+R%3BConti%2C+D%3BPilato%2C+B%3BLaCalamita%2C+R%3BPorcelli%2C+L%3BSimone%2C+G+M%3BTommasi%2C+S%3BTommasino%2C+M%3BParadiso%2C+A&rft.aulast=Sebastian&rft.aufirst=S&rft.date=2008-06-01&rft.volume=21&rft.issue=6&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=International+journal+of+molecular+medicine&rft.issn=11073756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-23 N1 - Date created - 2008-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis. AN - 70776816; 18497990 AB - The process of cell dissemination from the primary tumors to distant sites is the most harmful event during cancer progression, and the leading cause of cancer death. We have previously demonstrated that restoration of DLC1 tumor suppressor gene expression in the DLC1-negative Focus and 7703K human hepatocellular carcinoma (HCC) cell lines induced caspase-3 mediated apoptosis, reduced cell growth in vitro and tumorigenicity in vivo and diminished the ability to migrate through Matrigel, a property suggestive of metastatic potential in vivo. We now show that subcutaneous tumors developing after inoculation of Focus and 7703K cells into nude mice disseminate cells to liver and lung, and this process is markedly suppressed by restoration of DLC1 expression. Inhibition of tumor cell dissemination was associated with lower levels of RhoA activity, an increase in rounded cells and a reduction in actin stress fibers and focal adhesion molecules that are of critical importance in cancer cell invasion and metastasis. In addition, DLC1 down-regulated the expression of osteopontin and matrix metalloproteinase-9, which are highly up-regulated in most primary HCC with associated metastases. These observations implicate the DLC1 gene in suppression of HCC cell dissemination and identify novel cellular and genetic alterations that contribute to prevention of metastasis, a life-threatening event in cancer progression. JF - International journal of oncology AU - Zhou, Xiaoling AU - Zimonjic, Drazen B AU - Park, Sang-Won AU - Yang, Xu-Yu AU - Durkin, Marian E AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1285 EP - 1291 VL - 32 IS - 6 SN - 1019-6439, 1019-6439 KW - Actins KW - 0 KW - DLC1 protein, human KW - Drug Combinations KW - GTPase-Activating Proteins KW - Laminin KW - Matrix Metalloproteinase Inhibitors KW - Proteoglycans KW - Tumor Suppressor Proteins KW - Osteopontin KW - 106441-73-0 KW - matrigel KW - 119978-18-6 KW - Collagen KW - 9007-34-5 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - rhoA GTP-Binding Protein KW - EC 3.6.5.2 KW - Index Medicus KW - Neoplasm Invasiveness KW - Animals KW - Laminin -- metabolism KW - Osteopontin -- antagonists & inhibitors KW - Apoptosis KW - Cytoskeleton -- metabolism KW - Collagen -- metabolism KW - Humans KW - Osteopontin -- metabolism KW - Mice, Nude KW - Mice KW - Cell Proliferation KW - Matrix Metalloproteinase 9 -- metabolism KW - Tumor Cells, Cultured KW - Proteoglycans -- metabolism KW - Down-Regulation KW - rhoA GTP-Binding Protein -- metabolism KW - Carcinoma, Hepatocellular -- prevention & control KW - Carcinoma, Hepatocellular -- secondary KW - Lung Neoplasms -- secondary KW - Actins -- metabolism KW - Skin Neoplasms -- pathology KW - Liver Neoplasms -- secondary KW - Lung Neoplasms -- prevention & control KW - Liver Neoplasms -- prevention & control KW - Tumor Suppressor Proteins -- physiology KW - Carcinoma, Hepatocellular -- genetics KW - Lung Neoplasms -- genetics KW - rhoA GTP-Binding Protein -- antagonists & inhibitors KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70776816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=DLC1+suppresses+distant+dissemination+of+human+hepatocellular+carcinoma+cells+in+nude+mice+through+reduction+of+RhoA+GTPase+activity%2C+actin+cytoskeletal+disruption+and+down-regulation+of+genes+involved+in+metastasis.&rft.au=Zhou%2C+Xiaoling%3BZimonjic%2C+Drazen+B%3BPark%2C+Sang-Won%3BYang%2C+Xu-Yu%3BDurkin%2C+Marian+E%3BPopescu%2C+Nicholas+C&rft.aulast=Zhou&rft.aufirst=Xiaoling&rft.date=2008-06-01&rft.volume=32&rft.issue=6&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-30 N1 - Date created - 2008-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. AN - 70774197; 18499625 AB - Pruritus is the most common side effect of intrathecal morphine. Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions. Its effect in intrathecal morphine-induced pruritus has not yet undergone an evaluation. We randomly allocated 86 patients scheduled for lower limb surgery under spinal anesthesia into two equal groups that received either gabapentin 1200 mg or placebo 2 h before operation in a prospective, double-blind manner. All patients received an intrathecal injection of 15 mg of 0.5% isobaric bupivacaine and 0.2 mg preservative-free morphine. Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration. The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77.5% vs 47.5%; P = 0.01). The onset time of pruritus in the gabapentin group (6.2 +/- 1.8 h) was significantly delayed compared with that in the placebo group (3.1 +/- 0.8 h) (P < 0.0001). The severity of pruritus was significantly more in the placebo group compared with the gabapentin group at 3 and 6 h after intrathecal morphine injection. Preoperative gabapentin prevents pruritus induced by intrathecal morphine in patients undergoing lower limb surgery with spinal anesthesia. JF - Anesthesia and analgesia AU - Sheen, Michael J AU - Ho, Shung-Tai AU - Lee, Chian-Her AU - Tsung, Yu-Chi AU - Chang, Fang-Lin AD - Department of Anesthesiology, Tri-Service General Hospital, 325, Chenggong Rd, Section 2, Nei-hu, Taipei, 11490, Taiwan. mkjsheen@mail.ndmctsgh.edu.t Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1868 EP - 1872 VL - 106 IS - 6 KW - Amines KW - 0 KW - Anesthetics, Local KW - Antipruritics KW - Cyclohexanecarboxylic Acids KW - Narcotics KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - gabapentin KW - 6CW7F3G59X KW - Morphine KW - 76I7G6D29C KW - Bupivacaine KW - Y8335394RO KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Drug Administration Schedule KW - Double-Blind Method KW - Humans KW - Prospective Studies KW - Injections, Spinal KW - Adult KW - Treatment Outcome KW - Lower Extremity -- surgery KW - Time Factors KW - Female KW - Male KW - Anesthesia, Spinal KW - Amines -- administration & dosage KW - Orthopedic Procedures KW - Morphine -- adverse effects KW - Antipruritics -- administration & dosage KW - Narcotics -- administration & dosage KW - Narcotics -- adverse effects KW - Cyclohexanecarboxylic Acids -- administration & dosage KW - Pruritus -- chemically induced KW - gamma-Aminobutyric Acid -- administration & dosage KW - Premedication KW - Morphine -- administration & dosage KW - Pruritus -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70774197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Preoperative+gabapentin+prevents+intrathecal+morphine-induced+pruritus+after+orthopedic+surgery.&rft.au=Sheen%2C+Michael+J%3BHo%2C+Shung-Tai%3BLee%2C+Chian-Her%3BTsung%2C+Yu-Chi%3BChang%2C+Fang-Lin&rft.aulast=Sheen&rft.aufirst=Michael&rft.date=2008-06-01&rft.volume=106&rft.issue=6&rft.spage=1868&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=1526-7598&rft_id=info:doi/10.1213%2Fane.0b013e3181730130 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1213/ane.0b013e3181730130 ER - TY - JOUR T1 - Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics. AN - 70764360; 18417352 AB - Huntington's disease is caused by polyglutamine expansion in the huntingtin protein. Huntingtin directly interacts with profilin, a major actin monomer sequestering protein and a key integrator of signals leading to actin polymerization. We observed a progressive loss of profilin in the cerebral cortex of Huntington's disease patients, and in cell culture and Drosophila models of polyglutamine disease. This loss of profilin is likely due to increased degradation through the ubiquitin proteasome system. Profilin loss reduces the F/G actin ratio, indicating a shift in actin polymerization. Overexpression of profilin abolishes mutant huntingtin toxicity in cells and partially ameliorates the morphological and functional eye phenotype and extends lifespan in a transgenic polyglutamine Drosophila model. These results indicate a link between huntingtin and profilin and implicate profilin in Huntington's disease pathogenesis. JF - Neurobiology of disease AU - Burnett, Barrington G AU - Andrews, Jaime AU - Ranganathan, Srikanth AU - Fischbeck, Kenneth H AU - Di Prospero, Nicholas A AD - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA. burnettb@ninds.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 365 EP - 374 VL - 30 IS - 3 KW - Actins KW - 0 KW - Peptides KW - Profilins KW - polyglutamine KW - 26700-71-0 KW - Index Medicus KW - Animals KW - Humans KW - Aged KW - Disease Models, Animal KW - Amino Acid Sequence KW - Brain -- metabolism KW - Rats KW - Huntington Disease -- metabolism KW - Aged, 80 and over KW - Brain -- pathology KW - Adult KW - Molecular Sequence Data KW - Middle Aged KW - Huntington Disease -- pathology KW - Adolescent KW - Mutation KW - PC12 Cells KW - Huntington Disease -- genetics KW - Profilins -- metabolism KW - Gene Expression Regulation -- physiology KW - Actins -- genetics KW - Gene Targeting -- methods KW - Peptides -- metabolism KW - Actins -- metabolism KW - Peptides -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70764360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+disease&rft.atitle=Expression+of+expanded+polyglutamine+targets+profilin+for+degradation+and+alters+actin+dynamics.&rft.au=Burnett%2C+Barrington+G%3BAndrews%2C+Jaime%3BRanganathan%2C+Srikanth%3BFischbeck%2C+Kenneth+H%3BDi+Prospero%2C+Nicholas+A&rft.aulast=Burnett&rft.aufirst=Barrington&rft.date=2008-06-01&rft.volume=30&rft.issue=3&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+disease&rft.issn=1095-953X&rft_id=info:doi/10.1016%2Fj.nbd.2008.02.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-07 N1 - Date created - 2008-05-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Cell Biol. 2000 Sep;2(9):628-36 [10980704] Mol Cell Biol. 2000 Nov;20(21):8209-19 [11027290] J Cell Sci. 2000 Nov;113 Pt 21:3795-803 [11034907] Eur J Neurosci. 2001 Jan;13(1):206-10 [11135020] Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3832-6 [11274401] Exp Neurol. 2001 Jun;169(2):340-50 [11358447] Exp Nephrol. 2001;9(4):265-74 [11423726] Hum Mol Genet. 2001 Aug 15;10(17):1829-45 [11532992] Hum Mol Genet. 2002 Oct 1;11(21):2657-72 [12354791] Mol Biol Cell. 2003 Jan;14(1):118-28 [12529431] J Biol Chem. 2003 Aug 15;278(33):30849-53 [12807877] Trends Biochem Sci. 2003 Aug;28(8):425-33 [12932731] J Cell Biol. 2003 Sep 29;162(7):1267-79 [14517206] Annu Rev Neurosci. 2003;26:627-56 [12704223] Nat Neurosci. 2003 Nov;6(11):1194-200 [14555951] Neuron. 2003 Nov 13;40(4):685-94 [14622574] Trends Cell Biol. 2004 Aug;14(8):461-9 [15308213] Mol Cell. 2004 Sep 24;15(6):853-65 [15383276] J Neuropathol Exp Neurol. 1985 Nov;44(6):559-77 [2932539] Annu Rev Biochem. 1986;55:987-1035 [3527055] J Biol Chem. 1988 Apr 25;263(12):5910-5 [3356709] Science. 1992 Mar 27;255(5052):1671-7 [1313187] Cell. 1993 Mar 26;72(6):971-83 [8458085] Cell Motil Cytoskeleton. 1993;24(3):179-88 [8385578] Cell. 1993 Dec 3;75(5):1007-14 [8252614] Cell. 1994 Oct 21;79(2):303-14 [7954798] Development. 1994 Apr;120(4):717-28 [7600952] Science. 1995 Sep 1;269(5228):1270-2 [7652575] Hum Mol Genet. 1997 Mar;6(3):487-95 [9147654] Cell. 1997 Aug 8;90(3):549-58 [9267034] Biochemistry. 1999 Mar 2;38(9):2769-78 [10052948] Science. 1999 Jun 18;284(5422):1985-8 [10373116] J Cell Biol. 1999 Oct 4;147(1):151-62 [10508862] Mol Hum Reprod. 2005 Jan;11(1):53-64 [15591451] Eur J Neurosci. 2005 Jan;21(1):15-25 [15654839] J Neurocytol. 2004 Sep;33(5):517-33 [15906159] J Cell Sci. 2006 Oct 1;119(Pt 19):4127-37 [16968742] EMBO J. 2007 Jun 20;26(12):2991-3002 [17541406] Cell Mol Life Sci. 2007 Sep;64(17):2245-57 [17604996] Nat Cell Biol. 2007 Feb;9(2):139-48 [17187063] Hum Mol Genet. 2002 Nov 1;11(23):2815-28 [12393793] Genetics. 2002 Dec;162(4):1687-702 [12524342] Annu Rev Neurosci. 2000;23:217-47 [10845064] Nat Genet. 2000 Sep;26(1):44-50 [10973246] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.nbd.2008.02.007 ER - TY - JOUR T1 - Erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy. AN - 70762827; 18499877 AB - A case of erythema multiforme associated with prophylactic use of phenytoin during cranial radiation therapy is reported. A 60-year-old woman with intraductal adenocarcinoma of the breast and cerebral metastasis who had an implanted central venous catheter arrived at the hospital for the treatment of cerebral metastasis. She underwent whole brain irradiation and was given a total dose of 3750 cGy over 15 fractional doses spaced over three weeks. At the beginning of cranial radiation therapy, prophylactic oral ranitidine, oral dexamethasone, and oral phenytoin were initiated to prevent seizures. After 30 days of continuous prophylactic phenytoin and cranial radiation therapy, the patient developed an episode of coughing with yellow sputum, mucositis, and a minor skin reaction that was diagnosed in the emergency department as radiotherapy-associated lesions. After 2 days, the patient returned to the hospital with severe mucositis and an erythematous macular eruption on the scalp and auricular region within the radiation field. These were believed to be due to the radiation therapy, and the patient was subsequently hospitalized. The eruption dramatically extended over the next day, with itching micropapular urticarial lesions over large areas of the face, trunk, and genital region. The condition had worsened by the next day, with erythematous eruptions on the whole body (including the extremities), skin detachment, and vesicular lesions on the eyelids. The patient was then diagnosed toxic epidermal necrolysis. A patient with intraductal adenocarcinoma of the breast and cerebral metastasis developed erythema multiforme after receiving concurrent phenytoin and radiation therapy. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Barbosa, Leandro A AU - Teixeira, Carlos Roberto V AD - Oncology Clinic, Hospital of Cancer III, National Cancer Institute, Rio de Janeiro, Brazil. leaugust@yahoo.com.br Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 1048 EP - 1050 VL - 65 IS - 11 KW - Anticonvulsants KW - 0 KW - Phenytoin KW - 6158TKW0C5 KW - Index Medicus KW - Breast Neoplasms -- pathology KW - Humans KW - Cranial Irradiation -- adverse effects KW - Seizures -- etiology KW - Stevens-Johnson Syndrome -- etiology KW - Stevens-Johnson Syndrome -- diagnosis KW - Middle Aged KW - Seizures -- prevention & control KW - Breast Neoplasms -- radiotherapy KW - Female KW - Erythema Multiforme -- etiology KW - Carcinoma, Intraductal, Noninfiltrating -- secondary KW - Carcinoma, Intraductal, Noninfiltrating -- radiotherapy KW - Carcinoma, Intraductal, Noninfiltrating -- complications KW - Phenytoin -- therapeutic use KW - Brain Neoplasms -- complications KW - Brain Neoplasms -- radiotherapy KW - Anticonvulsants -- adverse effects KW - Phenytoin -- adverse effects KW - Anticonvulsants -- therapeutic use KW - Brain Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70762827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Erythema+multiforme+associated+with+prophylactic+use+of+phenytoin+during+cranial+radiation+therapy.&rft.au=Barbosa%2C+Leandro+A%3BTeixeira%2C+Carlos+Roberto+V&rft.aulast=Barbosa&rft.aufirst=Leandro&rft.date=2008-06-01&rft.volume=65&rft.issue=11&rft.spage=1048&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=1535-2900&rft_id=info:doi/10.2146%2Fajhp060580 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-21 N1 - Date created - 2008-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2146/ajhp060580 ER - TY - JOUR T1 - Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation. AN - 70752371; 18490767 AB - Inhalation of silica-containing dust particles induces silicosis, an inflammatory disease of the lungs characterized by the infiltration of macrophages and neutrophils into the lungs and the production of proinflammatory cytokines, chemokines, and reactive oxygen species (ROS). Synthetic oligodeoxynucleotides (ODN) expressing "immunosuppressive motifs" were recently shown to block pathologic inflammatory reactions in murine models of autoimmune disease. Based on those findings, the potential of suppressive ODN to prevent acute murine silicosis was examined. In vitro studies indicate that suppressive ODN blunt silica-induced macrophage toxicity. This effect was associated with a reduction in ROS production and p47phox expression (a subunit of NADPH oxidase key to ROS generation). In vivo studies show that pretreatment with suppressive (but not control) ODN reduces silica-dependent pulmonary inflammation, as manifest by fewer infiltrating cells, less cytokine/chemokine production, and lower levels of ROS (p < 0.01 for all parameters). Treatment with suppressive ODN also reduced disease severity and improved the survival (p < 0.05) of mice exposed to silica. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Sato, Takashi AU - Shimosato, Takeshi AU - Alvord, W Gregory AU - Klinman, Dennis M AD - Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 7648 EP - 7654 VL - 180 IS - 11 SN - 0022-1767, 0022-1767 KW - Cytokines KW - 0 KW - Oligonucleotides KW - Reactive Oxygen Species KW - Silicon Dioxide KW - 7631-86-9 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - neutrophil cytosolic factor 1 KW - Abridged Index Medicus KW - Index Medicus KW - Neutrophils -- metabolism KW - NADPH Oxidase -- metabolism KW - Macrophages, Alveolar -- metabolism KW - Animals KW - Neutrophils -- immunology KW - Silicon Dioxide -- toxicity KW - NADPH Oxidase -- immunology KW - Mice KW - Mice, Inbred BALB C KW - Macrophages, Alveolar -- immunology KW - Female KW - Cell Line KW - Lung -- immunology KW - Silicosis -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Reactive Oxygen Species -- immunology KW - Silicosis -- prevention & control KW - Silicosis -- pathology KW - Oligonucleotides -- pharmacology KW - Cytokines -- immunology KW - Silicosis -- immunology KW - Cytokines -- metabolism KW - Lung -- pathology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70752371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Suppressive+oligodeoxynucleotides+inhibit+silica-induced+pulmonary+inflammation.&rft.au=Sato%2C+Takashi%3BShimosato%2C+Takeshi%3BAlvord%2C+W+Gregory%3BKlinman%2C+Dennis+M&rft.aulast=Sato&rft.aufirst=Takashi&rft.date=2008-06-01&rft.volume=180&rft.issue=11&rft.spage=7648&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-18 N1 - Date created - 2008-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hippocampal lesions in rhesus monkeys disrupt emotional responses but not reinforcer devaluation effects. AN - 70741259; 18191111 AB - Although the role of the hippocampus in emotional behavior has long been recognized, the extent to which the hippocampus plays a role in the regulation and expression of emotion in rhesus monkeys has not been systematically explored. Rhesus monkeys (Macaca mulatta) with excitotoxic lesions of the hippocampal formation and unoperated control animals were assessed on two different types of emotional processing: defensive reactions to a potential predator (experiment 1) and ability to update the value of positive reinforcers, in this case food (experiment 2). Monkeys with aspiration lesions of the perirhinal cortex were also included in this study as an operated control group. In experiment 1, whereas both operated groups showed reduced latencies to retrieve food located near an innately fear-provoking stimulus, a fake snake, only monkeys with hippocampal lesions displayed reduced defensive reactions to the snake. In experiment 2, both operated groups performed as well as control animals when choosing objects flexibly based on the current value of a food. These findings dissociate the hippocampus and perirhinal cortex in fear expression and specifically implicate the hippocampal formation in generating responses to stimuli that are potentially threatening. JF - Biological psychiatry AU - Chudasama, Yogita AU - Wright, Katherine S AU - Murray, Elisabeth A AD - Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. yogita.chudasama@mcgill.ca Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 1084 EP - 1091 VL - 63 IS - 11 KW - Excitatory Amino Acid Agonists KW - 0 KW - Index Medicus KW - Animals KW - Discrimination Learning -- physiology KW - Reproducibility of Results KW - Reversal Learning -- physiology KW - Macaca mulatta KW - Excitatory Amino Acid Agonists -- toxicity KW - Male KW - Behavior, Animal KW - Satiation -- physiology KW - Reaction Time KW - Affective Symptoms -- etiology KW - Conditioning, Operant -- physiology KW - Reinforcement (Psychology) KW - Hippocampus -- injuries KW - Affective Symptoms -- psychology KW - Hippocampus -- physiopathology KW - Affective Symptoms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70741259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Hippocampal+lesions+in+rhesus+monkeys+disrupt+emotional+responses+but+not+reinforcer+devaluation+effects.&rft.au=Chudasama%2C+Yogita%3BWright%2C+Katherine+S%3BMurray%2C+Elisabeth+A&rft.aulast=Chudasama&rft.aufirst=Yogita&rft.date=2008-06-01&rft.volume=63&rft.issue=11&rft.spage=1084&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/10.1016%2Fj.biopsych.2007.11.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-16 N1 - Date created - 2008-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biopsych.2007.11.012 ER - TY - JOUR T1 - Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents. AN - 70738925; 18346464 AB - For glioblastomas, COX-2 expression is linked to poor survival. COX-2 effects are mediated by the receptors EP2 and EP4, whose regulation is poorly understood. The expression of EP4, and activation or inhibition of EP4 activity in human glioblastoma T98G cells, was found to correlate with growth on soft agar. Chemoprevention drugs, troglitazone (TGZ) and some COX inhibitors, significantly suppressed EP4 expression in T98G cells in a dose dependant manner. Specificity protein 1 (Sp-1) binding sites, located within region -197 to -160 of the human EP4 promoter, are important for the transcription initiation of the human EP4 gene and are responsible for the EP4 suppression by TGZ. Mutation in the Sp-1 sites altered the promoter activity of luciferase constructs and TGZ effects on the promoter. The inhibitory effect of TGZ on EP4 expression was reversed by PD98059, a MEK-1/Erk inhibitor. Immunoprecipitation-Western blot analysis detected Sp-1 phosphorylation that was dependent on TGZ-induced Erks activation. ChIP assay confirmed that Sp-1 phosphorylation decreases its binding to DNA and as a result, leads to the suppression of EP4 expression. Thus, we propose that the expression of EP4 is regulated by Sp-1, but phosphorylation of Sp-1 induced by TGZ suppresses this expression. This represents a new and unique mechanism for the regulation of the EP4 receptor expression. JF - Biochimica et biophysica acta AU - Kambe, Atsushi AU - Iguchi, Genzo AU - Moon, Yuseok AU - Kamitani, Hideki AU - Watanabe, Takashi AU - Eling, Thomas E AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1211 EP - 1219 VL - 1783 IS - 6 SN - 0006-3002, 0006-3002 KW - 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one KW - 0 KW - Antineoplastic Agents KW - Chromans KW - Cyclooxygenase 2 Inhibitors KW - DNA Primers KW - Flavonoids KW - PTGER2 protein, human KW - PTGER4 protein, human KW - RNA, Messenger KW - RNA, Small Interfering KW - Receptors, Prostaglandin E KW - Receptors, Prostaglandin E, EP2 Subtype KW - Receptors, Prostaglandin E, EP4 Subtype KW - Sp1 Transcription Factor KW - Thiazolidinediones KW - Luciferases KW - EC 1.13.12.- KW - Calcium-Calmodulin-Dependent Protein Kinases KW - EC 2.7.11.17 KW - troglitazone KW - I66ZZ0ZN0E KW - Index Medicus KW - Humans KW - Cyclooxygenase 2 Inhibitors -- pharmacology KW - Transcription, Genetic KW - Glioblastoma -- drug therapy KW - RNA, Messenger -- genetics KW - Promoter Regions, Genetic KW - Tumor Cells, Cultured KW - Calcium-Calmodulin-Dependent Protein Kinases -- antagonists & inhibitors KW - Glioblastoma -- metabolism KW - Chromatin Immunoprecipitation KW - RNA, Small Interfering -- pharmacology KW - Flavonoids -- pharmacology KW - Glioblastoma -- genetics KW - Astrocytoma -- genetics KW - DNA Primers -- genetics KW - Astrocytoma -- drug therapy KW - Astrocytoma -- metabolism KW - Immunoprecipitation KW - Luciferases -- metabolism KW - Phosphorylation -- drug effects KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Transfection KW - Colony-Forming Units Assay KW - DNA Primers -- chemistry KW - Sp1 Transcription Factor -- genetics KW - Receptors, Prostaglandin E -- metabolism KW - Receptors, Prostaglandin E -- antagonists & inhibitors KW - Receptors, Prostaglandin E -- genetics KW - Chromans -- pharmacology KW - Thiazolidinediones -- pharmacology KW - Sp1 Transcription Factor -- metabolism KW - Sp1 Transcription Factor -- antagonists & inhibitors KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70738925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Regulation+of+EP4+expression+via+the+Sp-1+transcription+factor%3A+inhibition+of+expression+by+anti-cancer+agents.&rft.au=Kambe%2C+Atsushi%3BIguchi%2C+Genzo%3BMoon%2C+Yuseok%3BKamitani%2C+Hideki%3BWatanabe%2C+Takashi%3BEling%2C+Thomas+E&rft.aulast=Kambe&rft.aufirst=Atsushi&rft.date=2008-06-01&rft.volume=1783&rft.issue=6&rft.spage=1211&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbamcr.2008.01.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-31 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2005 Sep 30;280(39):33240-9 [16061473] Cancer Res. 2005 Jun 1;65(11):4496-9 [15930264] Science. 2005 Dec 2;310(5753):1504-10 [16293724] Prog Lipid Res. 2006 Jan;45(1):1-16 [16337272] Cancer Res. 2001 Jun 1;61(11):4375-81 [11389063] J Biol Chem. 2001 Sep 7;276(36):33384-92 [11445565] Nat Med. 2001 Sep;7(9):1048-51 [11533709] J Neurochem. 2001 Dec;79(5):950-8 [11739606] Cancer Res. 2002 Jan 1;62(1):28-32 [11782353] J Biol Chem. 2002 Jan 25;277(4):2614-9 [11706038] Cancer Res. 2002 Feb 1;62(3):632-5 [11830510] J Biol Chem. 2002 Mar 22;277(12):9676-83 [11777901] J Biol Chem. 2002 May 10;277(19):16823-30 [11877441] J Biol Chem. 2002 Jun 7;277(23):20631-9 [11904305] Mol Pharmacol. 2003 Feb;63(2):401-8 [12527812] J Biol Chem. 2003 Feb 21;278(8):5845-53 [12475986] J Biol Chem. 2003 Apr 4;278(14):12151-6 [12566441] Neurol Res. 2003 Jun;25(4):370-6 [12870263] Am J Obstet Gynecol. 2003 Nov;189(5):1501-10 [14634592] Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):591-6 [14688410] J Biol Chem. 2004 Jan 23;279(4):2377-82 [14593115] Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):212-21 [14734472] Biochem Biophys Res Commun. 2004 Feb 20;314(4):1093-9 [14751245] Arch Neurol. 2006 Mar;63(3):337-41 [16533960] Cancer Res. 2006 Mar 15;66(6):3106-13 [16540660] Carcinogenesis. 2006 May;27(5):972-81 [16286461] Gastroenterology. 2006 Nov;131(5):1553-60 [17101328] Clin Cancer Res. 2004 Jan 15;10(2):538-45 [14760075] J Biol Chem. 2004 Feb 20;279(8):6883-92 [14662774] Carcinogenesis. 2004 Mar;25(3):349-57 [14633654] Oncogene. 2004 Jun 3;23(26):4614-23 [15064713] Mol Cell Biol. 1996 Apr;16(4):1659-67 [8657141] Genomics. 1996 Jul 1;35(1):182-8 [8661119] Cancer Res. 1999 Mar 1;59(5):987-90 [10070951] JAMA. 1999 Oct 6;282(13):1254-7 [10517428] Mol Pharmacol. 2005 Feb;67(2):356-64 [15509713] Cancer Res. 2005 Mar 1;65(5):1822-9 [15753380] Mol Cancer Ther. 2005 Mar;4(3):487-93 [15767558] Gene. 2005 Mar 28;348:1-11 [15777659] Biochem Biophys Res Commun. 2005 Jun 24;332(1):89-94 [15896303] J Biol Chem. 2005 Nov 4;280(44):37266-77 [16105842] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbamcr.2008.01.032 ER - TY - JOUR T1 - Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. AN - 70735894; 17728698 AB - Previous studies suggest that cannabinoid CB1 receptors do not appear to be involved in cocaine's rewarding effects, as assessed by the use of SR141716A, a prototypic CB1 receptor antagonist and CB1-knockout mice. In the present study, we found that blockade of CB1 receptors by AM 251 (1-10 mg/kg), a novel CB1 receptor antagonist, dose-dependently lowered (by 30-70%) the break point for cocaine self-administration under a progressive-ratio (PR) reinforcement schedule in rats. The same doses of SR141716 (freebase form) maximally lowered the break point by 35%, which did not reach statistical significance. Neither AM 251 nor SR141716 altered cocaine self-administration under a fixed-ratio (FR2) reinforcement schedule. AM 251 (0.1-3 mg/kg) also significantly and dose-dependently inhibited (by 25-90%) cocaine-enhanced brain stimulation reward (BSR), while SR141716 attenuated cocaine's BSR-enhancing effect only at 3 mg/kg (by 40%). When the dose was increased to 10 or 20 mg/kg, both AM 251 and SR141716 became less effective, with AM 251 only partially inhibiting cocaine-enhanced BSR and PR cocaine self-administration, and SR141716 having no effect. AM 251 alone, at all doses tested, had no effect on BSR, while high doses of SR141716 alone significantly inhibited BSR. These data suggest that blockade of CB1 receptors by relatively low doses of AM 251 dose-dependently inhibits cocaine's rewarding effects, whereas SR141716 is largely ineffective, as assessed by both PR cocaine self-administration and BSR. Thus, AM 251 or other more potent CB1 receptor antagonists deserve further study as potentially effective anti-cocaine medications. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Xi, Zheng-Xiong AU - Spiller, Krista AU - Pak, Arlene C AU - Gilbert, Jeremy AU - Dillon, Christopher AU - Li, Xia AU - Peng, Xiao-Qing AU - Gardner, Eliot L AD - Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA. zxi@intra.nida.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1735 EP - 1745 VL - 33 IS - 7 SN - 0893-133X, 0893-133X KW - Dopamine Uptake Inhibitors KW - 0 KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - AM 251 KW - 3I4FA44MAI KW - Cocaine KW - I5Y540LHVR KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - Electric Stimulation -- methods KW - Rats, Long-Evans KW - Reinforcement Schedule KW - Dose-Response Relationship, Drug KW - Piperidines -- pharmacology KW - Rats KW - Behavior, Animal -- drug effects KW - Pyrazoles -- pharmacology KW - Self Administration -- methods KW - Male KW - Conditioning, Operant -- drug effects KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Reward KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Brain -- drug effects KW - Cocaine -- administration & dosage KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70735894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Cannabinoid+CB1+receptor+antagonists+attenuate+cocaine%27s+rewarding+effects%3A+experiments+with+self-administration+and+brain-stimulation+reward+in+rats.&rft.au=Xi%2C+Zheng-Xiong%3BSpiller%2C+Krista%3BPak%2C+Arlene+C%3BGilbert%2C+Jeremy%3BDillon%2C+Christopher%3BLi%2C+Xia%3BPeng%2C+Xiao-Qing%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2008-06-01&rft.volume=33&rft.issue=7&rft.spage=1735&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adenovirus-mediated restoration of expression of the tumor suppressor gene DLC1 inhibits the proliferation and tumorigenicity of aggressive, androgen-independent human prostate cancer cell lines: prospects for gene therapy. AN - 70728623; 18369381 AB - Our recent study showing highly recurrent loss of function of DLC1 (deleted in liver cancer 1), a tumor suppressor gene in primary prostate carcinoma (PCA), implicates this gene in the pathogenesis of this disease. To evaluate the response of PCA to oncosuppressive activity of DLC1, we examined now the effects of adenoviral vector for human DLC1 transduction into the DLC1-deficient, androgen-independent (AI) and aggressive human PCA cell lines PC-3 and C4-2-B2. Adenovirus-mediated restoration of DLC1 expression inhibited the proliferation, invasiveness and anchorage-independent growth of PC-3 and C4-2-B2 cells in vitro as well as the tumorigenicity of PC-3 cells in nude mice. It also induced cell-cycle arrest, inhibited the activation of RhoA and the formation of actin stress fibers. DLC1 induced apoptosis in C4-2-B2 cells, whereas it did not elicit such an effect in PC-3 cells. The abundance of the antiapoptotic protein Bcl-2 was greater in PC-3 cells than in C4-2-B2 cells, and PC-3 cells were rendered sensitive to DLC1-induced apoptosis by treatment with the Bcl-2 inhibitor HA14-1. These results suggest that adenovirus-mediated DLC1 transfer, alone or together with other agents, such as inhibitors of Bcl-2 or histone deacetylase, might prove effective in the treatment of aggressive, AI-PCA. JF - Cancer gene therapy AU - Guan, M AU - Tripathi, V AU - Zhou, X AU - Popescu, N C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4262, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 371 EP - 381 VL - 15 IS - 6 KW - Androgens KW - 0 KW - DLC1 protein, human KW - GTPase-Activating Proteins KW - Tumor Suppressor Proteins KW - Index Medicus KW - Animals KW - Humans KW - Xenograft Model Antitumor Assays KW - Mice, Nude KW - Mice KW - Cell Line, Tumor KW - Male KW - Androgens -- metabolism KW - Prostatic Neoplasms -- pathology KW - Tumor Suppressor Proteins -- physiology KW - Tumor Suppressor Proteins -- genetics KW - Prostatic Neoplasms -- genetics KW - Genetic Therapy -- methods KW - Prostatic Neoplasms -- therapy KW - Cell Proliferation KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70728623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+gene+therapy&rft.atitle=Adenovirus-mediated+restoration+of+expression+of+the+tumor+suppressor+gene+DLC1+inhibits+the+proliferation+and+tumorigenicity+of+aggressive%2C+androgen-independent+human+prostate+cancer+cell+lines%3A+prospects+for+gene+therapy.&rft.au=Guan%2C+M%3BTripathi%2C+V%3BZhou%2C+X%3BPopescu%2C+N+C&rft.aulast=Guan&rft.aufirst=M&rft.date=2008-06-01&rft.volume=15&rft.issue=6&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Cancer+gene+therapy&rft.issn=1476-5500&rft_id=info:doi/10.1038%2Fcgt.2008.13 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-25 N1 - Date created - 2008-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/cgt.2008.13 ER - TY - JOUR T1 - Efficient estimation for the proportional hazards model with bivariate current status data. AN - 69409377; 17899375 AB - We consider efficient estimation of regression and association parameters jointly for bivariate current status data with the marginal proportional hazards model. Current status data occur in many fields including demographical studies and tumorigenicity experiments and several approaches have been proposed for regression analysis of univariate current status data. We discuss bivariate current status data and propose an efficient score estimation approach for the problem. In the approach, the copula model is used for joint survival function with the survival times assumed to follow the proportional hazards model marginally. Simulation studies are performed to evaluate the proposed estimates and suggest that the approach works well in practical situations. A real life data application is provided for illustration. JF - Lifetime data analysis AU - Wang, Lianming AU - Sun, Jianguo AU - Tong, Xingwei AD - Biostatistics Branch, National Institute of Environmental Health Sciences, MD A3-03, P.O. Box 12233, Research Triangle Park, NC 27709, USA. wangl3@niehs.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 134 EP - 153 VL - 14 IS - 2 SN - 1380-7870, 1380-7870 KW - Chloroprene KW - 126-99-8 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Mice, Inbred C57BL KW - Mice KW - Chloroprene -- toxicity KW - Lung Neoplasms -- chemically induced KW - Male KW - Female KW - Models, Statistical KW - Proportional Hazards Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69409377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lifetime+data+analysis&rft.atitle=Efficient+estimation+for+the+proportional+hazards+model+with+bivariate+current+status+data.&rft.au=Wang%2C+Lianming%3BSun%2C+Jianguo%3BTong%2C+Xingwei&rft.aulast=Wang&rft.aufirst=Lianming&rft.date=2008-06-01&rft.volume=14&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Lifetime+data+analysis&rft.issn=13807870&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-17 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An unusual variant of malignant struma ovarii. AN - 69398492; 18678124 AB - Struma ovarii is a highly specialised form of mature ovarian teratoma. When thyroid tissue constitutes 50% or more of the ovarian neoplasm, the tumour is termed struma ovarii. Malignant struma ovarii is rare and makes up 0.1-0.3% of all ovarian teratomas [2]. We describe a case of follicular variant of papillary carcinoma arising from struma ovarii with elevated CA-125 and pseudo-Meig syndrome. JF - The Ceylon medical journal AU - Amalaseelan, J V AU - Perera, K A AD - National Cancer Institute, Maharagama, Sri Lanka. julan_24@yahoo.com Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 55 EP - 56 VL - 53 IS - 2 SN - 0009-0875, 0009-0875 KW - Index Medicus KW - Thyroidectomy KW - Humans KW - Middle Aged KW - Female KW - Struma Ovarii -- surgery KW - Ovarian Neoplasms -- pathology KW - Struma Ovarii -- pathology KW - Ovarian Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69398492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Ceylon+medical+journal&rft.atitle=An+unusual+variant+of+malignant+struma+ovarii.&rft.au=Amalaseelan%2C+J+V%3BPerera%2C+K+A&rft.aulast=Amalaseelan&rft.aufirst=J&rft.date=2008-06-01&rft.volume=53&rft.issue=2&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=The+Ceylon+medical+journal&rft.issn=00090875&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-17 N1 - Date created - 2008-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Eosinophil-derived neurotoxin / RNase 2: connecting the past, the present and the future. AN - 69379624; 18673278 AB - The eosinophil-derived neurotoxin (EDN, also known as eosinophil protein-X) is best-known as one of the four major proteins found in the large specific granules of human eosinophilic leukocytes. Although it was named for its discovery and initial characterization as a neurotoxin, it is also expressed constitutively in human liver tissue and its expression can be induced in macrophages by proinflammatory stimuli. EDN and its divergent orthologs in rodents have ribonuclease activity, and are members of the extensive RNase A superfamily, although the relationship between the characterized physiologic functions and enzymatic activity remains poorly understood. Recent explorations into potential physiologic functions for EDN have provided us with some insights into its role in antiviral host defense, as a chemoattractant for human dendritic cells, and most recently, as an endogenous ligand for toll-like receptor (TLR)2. JF - Current pharmaceutical biotechnology AU - Rosenberg, H F AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. hrosenberg@niaid.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 135 EP - 140 VL - 9 IS - 3 KW - Ligands KW - 0 KW - Toll-Like Receptor 2 KW - Eosinophil-Derived Neurotoxin KW - EC 3.1.- KW - Index Medicus KW - Phylogeny KW - Animals KW - Models, Molecular KW - Humans KW - Neurotoxicity Syndromes -- etiology KW - Dendritic Cells -- drug effects KW - Toll-Like Receptor 2 -- metabolism KW - Neurotoxicity Syndromes -- enzymology KW - Neurotoxicity Syndromes -- metabolism KW - Eosinophil-Derived Neurotoxin -- physiology KW - Eosinophils -- enzymology KW - Eosinophil-Derived Neurotoxin -- chemistry KW - Eosinophil-Derived Neurotoxin -- toxicity KW - Eosinophil-Derived Neurotoxin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69379624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+biotechnology&rft.atitle=Eosinophil-derived+neurotoxin+%2F+RNase+2%3A+connecting+the+past%2C+the+present+and+the+future.&rft.au=Rosenberg%2C+H+F&rft.aulast=Rosenberg&rft.aufirst=H&rft.date=2008-06-01&rft.volume=9&rft.issue=3&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+biotechnology&rft.issn=1873-4316&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-27 N1 - Date created - 2008-08-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Evol. 1999 Dec;49(6):721-8 [10594173] Curr Allergy Asthma Rep. 2007 Apr;7(1):18-26 [17504657] Int Arch Allergy Immunol. 2001 Jul;125(3):241-9 [11490157] Biochemistry. 2002 Mar 12;41(10):3341-52 [11876642] Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5486-91 [11917138] AIDS. 2003 Mar 7;17(4):481-6 [12598767] Blood. 2003 Nov 1;102(9):3396-403 [12855582] Brief Bioinform. 2004 Jun;5(2):150-63 [15260895] Proc Natl Acad Sci U S A. 1979 Mar;76(3):1443-7 [286329] Proc Natl Acad Sci U S A. 1981 Aug;78(8):5165-9 [6946462] J Allergy Clin Immunol. 1982 Nov;70(5):361-6 [7130551] Immunology. 1983 Sep;50(1):19-26 [6885110] Am J Trop Med Hyg. 1985 Jul;34(4):735-45 [4025686] Proc Natl Acad Sci U S A. 1986 May;83(10):3146-50 [3458170] J Immunol. 1986 Nov 1;137(9):2913-7 [3760576] J Parasitol. 1987 Jun;73(3):523-9 [3598802] Am J Trop Med Hyg. 1988 Mar;38(2):327-34 [2451444] Biochemistry. 1988 Jun 14;27(12):4530-8 [3166997] Proc Natl Acad Sci U S A. 1989 Jun;86(12):4460-4 [2734298] J Immunol. 1989 Oct 1;143(7):2317-22 [2506283] Gene. 1989 Nov 15;83(1):161-7 [2591744] J Immunol. 1990 Apr 15;144(8):3166-73 [2324497] J Pediatr. 1992 Jan;120(1):28-32 [1731020] J Biol Chem. 1992 Jul 25;267(21):14859-65 [1634526] J Neurosci. 1994 Feb;14(2):538-44 [8301353] J Biol Chem. 1994 Oct 28;269(43):26739-45 [7929408] Nat Genet. 1995 Jun;10(2):219-23 [7663519] J Biol Chem. 1995 Sep 15;270(37):21539-44 [7665566] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5 [8901588] Protein Eng. 1997 Apr;10(4):463-70 [9194172] J Infect Dis. 1998 Jun;177(6):1458-64 [9607820] Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2678-81 [10077570] Am J Respir Crit Care Med. 1999 Jun;159(6):1918-24 [10351940] J Immunol. 2004 Nov 15;173(10):6134-42 [15528350] Genomics. 2005 Feb;85(2):208-20 [15676279] J Immunol. 2005 Oct 1;175(7):4320-30 [16177072] J Immunol. 2005 Oct 1;175(7):4735-44 [16177121] Annu Rev Immunol. 2006;24:147-74 [16551246] AIDS Res Hum Retroviruses. 2006 Sep;22(9):897-907 [16989616] Mol Divers. 2006 Nov;10(4):585-97 [16969722] J Immunol. 2007 Mar 1;178(5):3134-42 [17312161] J Allergy Clin Immunol. 2007 Jun;119(6):1303-10; quiz 1311-2 [17481712] Blood. 2007 Sep 1;110(5):1578-86 [17495130] Adv Exp Med Biol. 2007;601:185-94 [17713005] J Exp Med. 2008 Jan 21;205(1):79-90 [18195069] J Leukoc Biol. 2008 May;83(5):1079-87 [18211964] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4701-6 [10758160] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [What is the Japanese mental health service lacking for drug dependence rehabilitation?]. AN - 69338039; 18646643 AB - Methamphetamine (MAP) has been one of the most popular abused drugs in Japan since 1950s. Nevertheless, although some of the psychiatric hospitals in Japan have treated psychosis caused by MAP, few have committed to rehabilitation for MAP dependence, which most of the individuals with MAP psychosis suffer from. This paper described the actual situation around the rehabilitation for MAP dependence in Japan, and proposed the necessity of establishing the new outpatient programs for the individuals with MAP dependence in Japan, introducing the Matrix Model, the outpatient program which has been served for individuals with MAP dependence since the middle of 1980s in the West Coast area in U.S.A. Additionally, we also introduced the principle and contents of our new outpatient program, the Serigaya Methamphetamine Relapse Prevention Program (SMARPP), which we have tried to conduct in Kanagawa Psychiatric Center Serigaya Hospital, consisting of the three a week groups sessions including relapse prevention program, motivational interviewing attitudes, and urine-monitoring following the Matrix Model. We discussed the future model of rehabilitation systems for drug dependence in Japan, and insisted that the current practices of the modified SMARPP starting in four psychiatric hospitals and one mental health and welfare center will be expected to establish the future outpatient program for MAP dependence in Japan. JF - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence AU - Matsumoto, Toshihiko AU - Kobayashi, Ohji AD - Center for Suicide Prevention, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira 187-8553, Japan. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 172 EP - 187 VL - 43 IS - 3 SN - 1341-8963, 1341-8963 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Models, Psychological KW - Substance Abuse Treatment Centers KW - Humans KW - Japan KW - Hospitals, Psychiatric KW - Methamphetamine -- adverse effects KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69338039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.atitle=%5BWhat+is+the+Japanese+mental+health+service+lacking+for+drug+dependence+rehabilitation%3F%5D.&rft.au=Matsumoto%2C+Toshihiko%3BKobayashi%2C+Ohji&rft.aulast=Matsumoto&rft.aufirst=Toshihiko&rft.date=2008-06-01&rft.volume=43&rft.issue=3&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.issn=13418963&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-03 N1 - Date created - 2008-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. AN - 69296253; 18381359 AB - Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT), also known as testis-specific protein Y-encoded-like (TSPYL-2) and cell division autoantigen-1, is a member of the testis-specific protein Y-encoded (TSPY)/TSPY-L/SET/nucleosome assembly protein-1 superfamily. DENTT is expressed in various tissues including normal human lung. Here, we investigate the involvement of DENTT in cancer promotion and progression. DENTT messenger RNA (mRNA) and protein levels were shown to be markedly downregulated in human and mouse primary tumors and in human tumor cell lines. Overexpression of DENTT in human lung (A549-DENTT) and breast (MCF-7-DENTT) cancer cells resulted in diminished growth potential in anchorage-dependent growth assays and reduced capacity to form colonies under anchorage-independent culture conditions. The migratory potential of A549-DENTT and MCF-7-DENTT cells was reduced when compared with empty vector control cells. Treating human lung cell lines with demethylating agents increased DENTT expression significantly. DENTT expression pattern paralleled that of transforming growth factor-beta1 (TGF-beta1) in normal and malignant tissue and ectopic expression or treatment with TGF-beta1 in lung cancer cells was followed by increased DENTT mRNA and protein levels. Collectively, our results suggest a role for DENTT as a suppressor of the tumorigenic phenotype. JF - Carcinogenesis AU - Kandalaft, Lana E AU - Zudaire, Enrique AU - Portal-Núñez, Sergio AU - Cuttitta, Frank AU - Jakowlew, Sonia B AD - Cell and Cancer Biology Branch, National Cancer Institute, Advanced Technology Center, Gaithersburg, MD 20877, USA. kandalal@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1282 EP - 1289 VL - 29 IS - 6 KW - Nuclear Proteins KW - 0 KW - RNA, Messenger KW - SE20-4 protein, human KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Animals KW - Transforming Growth Factor beta1 -- metabolism KW - Humans KW - RNA, Messenger -- analysis KW - Cell Line, Tumor KW - Cell Proliferation KW - Reverse Transcriptase Polymerase Chain Reaction KW - Blotting, Western KW - Transfection KW - Cell Movement -- physiology KW - Enzyme-Linked Immunosorbent Assay KW - Gene Expression Regulation KW - Immunohistochemistry KW - Female KW - Nuclear Proteins -- genetics KW - Gene Expression KW - Breast Neoplasms -- metabolism KW - Nuclear Proteins -- metabolism KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69296253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Differentially+expressed+nucleolar+transforming+growth+factor-beta1+target+%28DENTT%29+exhibits+an+inhibitory+role+on+tumorigenesis.&rft.au=Kandalaft%2C+Lana+E%3BZudaire%2C+Enrique%3BPortal-N%C3%BA%C3%B1ez%2C+Sergio%3BCuttitta%2C+Frank%3BJakowlew%2C+Sonia+B&rft.aulast=Kandalaft&rft.aufirst=Lana&rft.date=2008-06-01&rft.volume=29&rft.issue=6&rft.spage=1282&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn087 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-29 N1 - Date created - 2008-07-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 1995 Aug;130(3):661-73 [7622566] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4 [8421714] Nat Med. 1998 Jul;4(7):802-7 [9662371] Biochim Biophys Acta. 2005 May 1;1728(3):163-80 [15823505] Neoplasia. 2005 Aug;7(8):748-60 [16207477] Carcinogenesis. 2005 Nov;26(11):1856-67 [15958521] Cancer Res. 2006 Apr 15;66(8):4055-64 [16618725] BMC Cancer. 2006;6:154 [16762081] Cancer Res. 2006 Aug 1;66(15):7490-501 [16885346] J Biol Chem. 2007 Apr 20;282(16):11722-31 [17317670] Cell. 2000 Jan 7;100(1):57-70 [10647931] Mol Carcinog. 2000 Oct;29(2):112-26 [11074608] Exp Lung Res. 2000 Dec;26(8):685-707 [11195465] Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):629-34 [11149944] Genomics. 2001 Apr 15;73(2):179-93 [11318608] Nature. 2001 Apr 26;410(6832):1111-6 [11323676] J Biol Chem. 2001 Sep 7;276(36):33665-74 [11395479] Dev Dyn. 2002 Jun;224(2):186-99 [12112471] J Biol Chem. 2003 Jan 10;278(2):1158-64 [12407107] Neuron. 2004 Apr 8;42(1):113-28 [15066269] J Biol Chem. 1996 Sep 20;271(38):23345-51 [8798536] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn087 ER - TY - JOUR T1 - PAHs, PAH-induced carcinogenic potency, and particle-extract-Induced cytotoxicity of traffic-related nano/ultrafine particles. AN - 69275818; 18589992 AB - Polycyclic aromatic hydrocarbons (PAHs) bound in nano/ ultrafine particles from vehicle emissions may cause adverse health effects. However, little is known about the characteristics of the nanoparticle-bound PAHs and the PAH-associated carcinogenic potency/cytotoxicity; therefore, traffic-related nano/ultrafine particles were collected in this study using a microorifice uniform deposition impactor(MOUDI) and a nano-MOUDI. For PM0.056--18, the difference in size-distribution of particulate total-PAHs between non-after-rain and after-rain samples was statistically significant at alpha = 0.05; however, this difference was not significant for PM0.01--0.056. The PAH correlation between PM0.01--0.1 and PM0.1--1.8 was lower for the after-rain samples than forthe non-after-rain samples. The average particulate total-PAHs in five samplings displayed a trimodal distribution with a major peak in the Aitken mode (0.032--0.056 microm). About half of the particulate total-PAHs were in the ultrafine size range. The BaPeq sums of BaP, IND, and DBA (with toxic equivalence factors > or = 0.1) accounted for approximately 90% of the total-BaPeq in the nano/ultrafine particles, although these three compounds contributed little to the mass of the sampled particles. The mean content of the particle-bound total-PAHs/-BaPeqs and the PAH/BaPeq-derived carcinogenic potency followed the order nano > ultrafine > fine > coarse. For a sunny day sample, the cytotoxicity of particle extracts (using 1:1 (v/v) n-hexane/dichloromethane) was significantly higher (p < 0.05) for the nano (particularly the 10-18 nm)/ultrafine particles than for the coarser particles and bleomycin. Therefore, traffic-related nano and ultrafine particles are possibly cytotoxic. JF - Environmental science & technology AU - Lin, Chih-Chung AU - Chen, Shui-Jen AU - Huang, Kuo-Lin AU - Lee, Wen-Jhy AU - Lin, Wen-Yinn AU - Tsai, Jen-Hsiung AU - Chaung, Hso-Chi AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu, PingTung 91201, Taiwan. Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 4229 EP - 4235 VL - 42 IS - 11 SN - 0013-936X, 0013-936X KW - Air Pollutants KW - 0 KW - Carcinogens, Environmental KW - Particulate Matter KW - Polycyclic Aromatic Hydrocarbons KW - Vehicle Emissions KW - Index Medicus KW - Swine KW - Environmental Monitoring KW - Weather KW - Animals KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Particle Size KW - Macrophages, Alveolar -- drug effects KW - Male KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Particulate Matter -- toxicity KW - Vehicle Emissions -- toxicity KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Carcinogens, Environmental -- toxicity KW - Carcinogens, Environmental -- analysis KW - Air Pollutants -- analysis KW - Particulate Matter -- analysis KW - Air Pollutants -- toxicity KW - Motor Vehicles KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69275818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=PAHs%2C+PAH-induced+carcinogenic+potency%2C+and+particle-extract-Induced+cytotoxicity+of+traffic-related+nano%2Fultrafine+particles.&rft.au=Lin%2C+Chih-Chung%3BChen%2C+Shui-Jen%3BHuang%2C+Kuo-Lin%3BLee%2C+Wen-Jhy%3BLin%2C+Wen-Yinn%3BTsai%2C+Jen-Hsiung%3BChaung%2C+Hso-Chi&rft.aulast=Lin&rft.aufirst=Chih-Chung&rft.date=2008-06-01&rft.volume=42&rft.issue=11&rft.spage=4229&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-31 N1 - Date created - 2008-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Translation of a tobacco survey into Spanish and Asian languages: the Tobacco Use Supplement to the Current Population Survey. AN - 69260211; 18584471 AB - Because of the vital need to attain cross-cultural comparability of estimates of tobacco use across subgroups of the U.S. population that differ in primary language use, the National Cancer Institute (NCI) Tobacco Use Special Cessation Supplement to the Current Population Survey (TUSCS-CPS) was translated into Spanish, Chinese (Mandarin and Cantonese), Korean, Vietnamese, and Khmer (Cambodian). The questionnaire translations were extensively tested using an eight-step process that focused on both translation procedures and empirical pretesting. The resulting translations are available on the Internet at http://riskfactor.cancer.gov/studies/tus-cps/translation/questionnaires.html for tobacco researchers to use in their own surveys, either in full, or as material to be selected as appropriate. This manuscript provides information to guide researchers in accessing and using the translations, and describes the empirical procedures used to develop and pretest them (cognitive interviewing and behavior coding). We also provide recommendations concerning the further development of questionnaire translations. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Willis, Gordon AU - Lawrence, Deirdre AU - Hartman, Anne AU - Stapleton Kudela, Martha AU - Levin, Kerry AU - Forsyth, Barbara AD - Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7344, USA. willisg@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1075 EP - 1084 VL - 10 IS - 6 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - United States KW - Reproducibility of Results KW - Humans KW - Cross-Cultural Comparison KW - Population Surveillance -- methods KW - Translations KW - Surveys and Questionnaires -- classification KW - Hispanic Americans KW - Tobacco Use Disorder -- ethnology KW - Asian Americans KW - Smoking -- ethnology KW - Language KW - Tobacco Use Disorder -- diagnosis KW - Tobacco Use Disorder -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69260211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Translation+of+a+tobacco+survey+into+Spanish+and+Asian+languages%3A+the+Tobacco+Use+Supplement+to+the+Current+Population+Survey.&rft.au=Willis%2C+Gordon%3BLawrence%2C+Deirdre%3BHartman%2C+Anne%3BStapleton+Kudela%2C+Martha%3BLevin%2C+Kerry%3BForsyth%2C+Barbara&rft.aulast=Willis&rft.aufirst=Gordon&rft.date=2008-06-01&rft.volume=10&rft.issue=6&rft.spage=1075&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/10.1080%2F14622200802087572 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-18 N1 - Date created - 2008-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Public Health Nurs. 2000 Jan-Feb;17(1):61-70 [10675054] Nicotine Tob Res. 2007 Feb;9(2):169-84 [17365748] J Pediatr Psychol. 2000 Sep;25(6):403-14 [10980045] Public Health Rep. 2001;116 Suppl 1:223-43 [11889288] Arch Phys Med Rehabil. 2003 Apr;84(4 Suppl 2):S29-34 [12692769] West J Nurs Res. 2004 Apr;26(3):307-20 [15068554] Public Health Rep. 2004 Jul-Aug;119(4):388-95 [15219795] Am J Prev Med. 2004 Aug;27(2):118-25 [15261898] Nicotine Tob Res. 2004 Aug;6(4):621-9 [15370158] Vital Health Stat 2. 1968 Mar;(26):1-65 [5301315] Ann Epidemiol. 1997 Jul;7(5):334-42 [9250628] MMWR Recomm Rep. 1998 Oct 9;47(RR-18):v-xv, 1-16 [9784089] Am Psychol. 1999 Jun;54(6):424-33 [10392472] Health Educ Res. 2004 Dec;19(6):615-25 [15199009] Nicotine Tob Res. 2005 Jun;7(3):387-96 [16085506] Med Care. 2006 Nov;44(11 Suppl 3):S17-20 [17060823] Med Care. 2006 Nov;44(11 Suppl 3):S21-30 [17060830] Med Care. 2006 Nov;44(11 Suppl 3):S5-9 [17060835] Med Care. 2000 Sep;38(9 Suppl):II102-24 [10982096] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/14622200802087572 ER - TY - JOUR T1 - Low-fidelity DNA synthesis by human DNA polymerase theta. AN - 69243707; 18503084 AB - Human DNA polymerase theta (pol or POLQ) is a proofreading-deficient family A enzyme implicated in translesion synthesis (TLS) and perhaps in somatic hypermutation (SHM) of immunoglobulin genes. These proposed functions and kinetic studies imply that pol may synthesize DNA with low fidelity. Here, we show that when copying undamaged DNA, pol generates single base errors at rates 10- to more than 100-fold higher than for other family A members. Pol adds single nucleotides to homopolymeric runs at particularly high rates, exceeding 1% in certain sequence contexts, and generates single base substitutions at an average rate of 2.4 x 10(-3), comparable to inaccurate family Y human pol kappa (5.8 x 10(-3)) also implicated in TLS. Like pol kappa, pol is processive, implying that it may be tightly regulated to avoid deleterious mutagenesis. Pol also generates certain base substitutions at high rates within sequence contexts similar to those inferred to be copied by pol during SHM of immunoglobulin genes in mice. Thus, pol is an exception among family A polymerases, and its low fidelity is consistent with its proposed roles in TLS and SHM. JF - Nucleic acids research AU - Arana, Mercedes E AU - Seki, Mineaki AU - Wood, Richard D AU - Rogozin, Igor B AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 3847 EP - 3856 VL - 36 IS - 11 KW - Nucleotides KW - 0 KW - DNA KW - 9007-49-2 KW - DNA polymerase theta KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Nucleotides -- metabolism KW - Somatic Hypermutation, Immunoglobulin KW - Humans KW - Mutation KW - Nucleotides -- analysis KW - DNA -- chemistry KW - DNA -- biosynthesis KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69243707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Low-fidelity+DNA+synthesis+by+human+DNA+polymerase+theta.&rft.au=Arana%2C+Mercedes+E%3BSeki%2C+Mineaki%3BWood%2C+Richard+D%3BRogozin%2C+Igor+B%3BKunkel%2C+Thomas+A&rft.aulast=Arana&rft.aufirst=Mercedes&rft.date=2008-06-01&rft.volume=36&rft.issue=11&rft.spage=3847&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkn310 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-21 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2006;34(17):4731-42 [16971464] Biochim Biophys Acta. 1992 Nov 15;1171(1):11-8 [1420357] DNA Repair (Amst). 2007 Feb 4;6(2):213-23 [17118716] J Biol Chem. 2007 Jun 15;282(24):17387-94 [17449470] J Biol Chem. 1997 Jan 24;272(4):2559-69 [8999973] J Biol Chem. 1997 Aug 8;272(32):20205-12 [9242698] J Mol Biol. 1999 Jun 18;289(4):835-50 [10369765] Genomics. 1999 Jul 1;59(1):90-6 [10395804] EMBO J. 2004 Nov 10;23(22):4484-94 [15496986] Mol Cell Biol. 2004 Dec;24(23):10381-9 [15542845] Adv Protein Chem. 2004;69:137-65 [15588842] J Exp Med. 2005 Apr 18;201(8):1191-6 [15824086] J Immunol. 2005 Jun 15;174(12):7781-6 [15944281] Annu Rev Biochem. 2005;74:317-53 [15952890] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8656-61 [15939880] J Biol Chem. 2005 Jun 24;280(25):23446-50 [15879599] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13986-91 [16172387] J Biol Chem. 1993 May 15;268(14):10312-23 [7683674] J Biol Chem. 1993 May 15;268(14):10324-34 [7683675] J Biol Chem. 1993 Jun 25;268(18):13462-71 [8390464] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6830-4 [8041704] Methods Enzymol. 1995;262:217-32 [8594349] EMBO J. 2005 Nov 2;24(21):3757-69 [16222339] Cell. 2006 Jan 27;124(2):331-42 [16439207] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] J Biol Chem. 2006 May 19;281(20):13869-72 [16571727] Front Biosci. 2006;11:2496-517 [16720328] Nat Cell Biol. 2006 Jun;8(6):640-2 [16738703] Cell Cycle. 2006 May;5(10):1044-7 [16687932] J Biol Chem. 2006 Aug 18;281(33):23445-55 [16787914] Mol Cell. 2006 Oct 6;24(1):115-25 [17018297] Plant Mol Biol. 2007 Jul;64(5):601-11 [17522954] DNA Repair (Amst). 2008 Jan 1;7(1):119-27 [17920341] Mol Cell. 2007 Dec 14;28(5):702-7 [18082594] Eur J Immunol. 2008 Jan;38(1):227-39 [18081040] Mol Cell. 2007 Dec 28;28(6):1058-70 [18158902] Cell Res. 2008 Jan;18(1):148-61 [18166979] J Biol Chem. 1996 Oct 4;271(40):24954-61 [8798775] J Biol Chem. 1999 Nov 19;274(47):33313-9 [10559208] J Biol Chem. 2000 Dec 15;275(50):39678-84 [11006276] Nat Immunol. 2001 Jun;2(6):530-6 [11376340] Nat Immunol. 2001 Jun;2(6):537-41 [11376341] J Mol Biol. 2001 Sep 14;312(2):335-46 [11554790] Cell. 2001 Oct 5;107(1):91-102 [11595188] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] Annu Rev Biochem. 2002;71:191-219 [12045095] J Mol Biol. 2002 May 31;319(2):359-69 [12051913] Genetics. 2003 Mar;163(3):1031-40 [12663541] J Biol Chem. 2003 Aug 22;278(34):32014-9 [12794064] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] Nucleic Acids Res. 2003 Nov 1;31(21):6117-26 [14576298] J Biol Chem. 2003 Oct 31;278(44):43770-80 [12882968] Int J Cancer. 2004 Mar10;109(1):9-16 [14735462] J Exp Med. 2004 Jan 19;199(2):265-70 [14734526] J Exp Med. 2004 Apr 5;199(7):917-24 [15051760] Cold Spring Harb Symp Quant Biol. 1966;31:77-84 [5237214] Biochim Biophys Acta. 1988 Nov 10;951(1):1-15 [2847793] Nucleic Acids Res. 1990 Jul 11;18(13):3739-44 [2374708] J Biol Chem. 1990 Aug 15;265(23):13878-87 [2199444] DNA Repair (Amst). 2006 Nov 8;5(11):1384-91 [16890500] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkn310 ER - TY - JOUR T1 - Promoter-proximal Pol II: when stalling speeds things up. AN - 69233298; 18469524 AB - Expression of genes was long thought to be regulated primarily at the level of RNA polymerase II (Pol II) recruitment to a gene promoter, and the dozen genes that did not fit this paradigm were regarded as exceptions. However, recent analyses of genome-wide Pol II distribution in Drosophila and mammalian systems have indicated that a large number of genes might be regulated at a step subsequent to Pol II recruitment, during early transcription elongation. At these genes, Pol II begins transcription but stalls after synthesizing a short RNA, and it is the release of this engaged Pol II from the promoter-proximal region that is rate limiting for transcription. Notably, promoter-proximal Pol II stalling is prevalent at genes involved in development and response to stimuli, suggesting that Pol II stalling during early elongation plays important roles in rapid and precise control of gene expression. Here we briefly summarize the current data on promoter-proximal Pol II stalling and discuss implications of this newly appreciated regulatory strategy. JF - Cell cycle (Georgetown, Tex.) AU - Nechaev, Sergei AU - Adelman, Karen AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. nechaevs@niehs.nih.gov Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 1539 EP - 1544 VL - 7 IS - 11 KW - RNA Polymerase II KW - EC 2.7.7.- KW - Index Medicus KW - Animals KW - Drosophila KW - RNA Polymerase II -- metabolism KW - Promoter Regions, Genetic -- physiology KW - Gene Expression Regulation -- physiology KW - RNA Polymerase II -- genetics KW - Models, Biological KW - Transcription, Genetic -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69233298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Promoter-proximal+Pol+II%3A+when+stalling+speeds+things+up.&rft.au=Nechaev%2C+Sergei%3BAdelman%2C+Karen&rft.aulast=Nechaev&rft.aufirst=Sergei&rft.date=2008-06-01&rft.volume=7&rft.issue=11&rft.spage=1539&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-29 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's disease. AN - 69231546; 18500642 AB - The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients. JF - Cellular and molecular life sciences : CMLS AU - Crawley, J N AD - Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Porter Neuroscience Research, Center Building 35, Room 1C-903, Mail Code 3730, Bethesda, Maryland 20892-3730, USA. crawleyj@intra.nimh.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1836 EP - 1841 VL - 65 IS - 12 SN - 1420-682X, 1420-682X KW - Galanin KW - 88813-36-9 KW - Index Medicus KW - Rats KW - Animals KW - Memory -- drug effects KW - Humans KW - Learning -- drug effects KW - Mice KW - Cognition -- drug effects KW - Galanin -- antagonists & inhibitors KW - Alzheimer Disease -- drug therapy KW - Galanin -- physiology KW - Galanin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69231546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.atitle=Galanin+impairs+cognitive+abilities+in+rodents%3A+relevance+to+Alzheimer%27s+disease.&rft.au=Crawley%2C+J+N&rft.aulast=Crawley&rft.aufirst=J&rft.date=2008-06-01&rft.volume=65&rft.issue=12&rft.spage=1836&rft.isbn=&rft.btitle=&rft.title=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.issn=1420682X&rft_id=info:doi/10.1007%2Fs00018-008-8158-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-06-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Aug 15;20(16):6276-81 [10934278] Neuroscience. 2000;100(2):259-86 [11008166] Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11569-74 [11016971] Prog Neuropsychopharmacol Biol Psychiatry. 2001 Jan;25(1):283-99 [11263757] Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4184-9 [11259657] Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14006-11 [11698649] Neuroscientist. 2001 Dec;7(6):506-17 [11765128] CNS Drug Rev. 2001 Winter;7(4):445-70 [11830760] J Mol Neurosci. 2002 Feb-Apr;18(1-2):151-65 [11931346] Learn Mem. 2002 Jul-Aug;9(4):178-90 [12177231] J Chem Neuroanat. 2002 Jul;24(2):109-16 [12191727] Neuropeptides. 2002 Apr-Jun;36(2-3):145-56 [12359505] Neuropharmacology. 2003 Jan;44(1):40-8 [12559120] Neuroscience. 2003;117(1):221-7 [12605908] Behav Neurosci. 2003 Feb;117(1):21-31 [12619904] Neurobiol Learn Mem. 2003 Jul;80(1):42-54 [12737933] Neuropsychopharmacology. 2003 Jun;28(6):1031-44 [12700679] Neurosci Lett. 2003 Jul 24;345(3):153-6 [12842279] Neurobiol Dis. 2003 Dec;14(3):579-94 [14678773] Eur J Neurosci. 2004 Mar;19(5):1384-96 [15016096] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5 [15240875] Regul Pept. 2004 Oct 15;122(2):91-8 [15380926] Neurobiol Aging. 2004 Nov-Dec;25(10):1309-14 [15465628] Experientia. 1987 Jul 15;43(7):768-80 [2885215] Proc Natl Acad Sci U S A. 1987 Oct;84(20):7339-43 [2444980] Neurosci Lett. 1988 Jun 7;88(3):331-5 [2455255] Proc Natl Acad Sci U S A. 1988 Dec;85(24):9841-5 [2462255] J Comp Neurol. 1988 Jul 22;273(4):543-57 [2463283] Eur J Pharmacol. 1989 May 19;164(2):355-60 [2474449] Neurosci Lett. 1991 May 13;126(1):29-32 [1714064] Life Sci. 1992;50(13):939-44 [1372382] Brain Res. 1992 Jun 5;582(1):71-7 [1379875] Neuroscience. 1992 Nov;51(1):1-5 [1281521] Eur J Pharmacol. 1993 Mar 15;245(1):1-7 [7682961] Behav Neurosci. 1993 Jun;107(3):458-67 [7687133] Brain Res. 1993 Sep 17;622(1-2):330-6 [7694768] J Neurosci. 1993 Dec;13(12):5119-25 [7504722] Dementia. 1993 Sep-Oct;4(5):237-50 [7505157] Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8047-51 [7520174] Behav Neurosci. 1994 Oct;108(5):941-50 [7530011] Neurosci Behav Physiol. 1994 Sep-Oct;24(5):429-32 [7530815] Peptides. 1995;16(7):1283-6 [8545252] Neurosci Lett. 1996 Jul 5;212(1):21-4 [8823753] Brain Res. 1996 Feb 12;709(1):81-7 [8869559] Behav Neurosci. 1996 Oct;110(5):1025-32 [8919005] Brain Pathol. 1997 Apr;7(2):723-30 [9161723] Behav Neurosci. 1997 Jun;111(3):552-63 [9189270] Neuroscience. 1998 Mar;83(1):123-36 [9466403] J Neurosci. 1998 Jul 1;18(13):5078-85 [9634573] Brain Res. 1998 Nov 30;813(1):50-6 [9824666] Results Probl Cell Differ. 1999;26:257-91 [10453468] Neuropeptides. 2004 Dec;38(6):331-43 [15567469] Mol Cell Biol. 2005 Jun;25(11):4804-11 [15899880] Neuroscience. 2005;133(2):371-80 [15885921] Neuropeptides. 2005 Jun;39(3):233-7 [15893372] Neuropeptides. 2005 Jun;39(3):125-42 [15908000] Neuropeptides. 2005 Jun;39(3):143-6 [15944002] Neuropeptides. 2005 Jun;39(3):207-10 [15944013] Neuropeptides. 2005 Jun;39(3):239-43 [15944016] Neuropeptides. 2005 Jun;39(3):289-92 [15944024] Neuropeptides. 2005 Jun;39(3):299-304 [15944026] Neuromolecular Med. 2005;7(1-2):157-80 [16052044] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94 [16287967] CNS Neurol Disord Drug Targets. 2006 Apr;5(2):225-32 [16611095] Dement Geriatr Cogn Disord. 2006;21(4):205-14 [16410678] Pharmacol Biochem Behav. 2006 Mar;83(3):428-40 [16626795] Neurosci Lett. 2006 Sep 11;405(1-2):111-5 [16854525] Curr Opin Drug Discov Devel. 2006 Sep;9(5):560-70 [17002216] Drug News Perspect. 2006 Oct;19(8):461-7 [17160146] Pharmacol Biochem Behav. 2007 Jan;86(1):8-20 [17257664] Brain Res. 2007 Mar 23;1138:10-20 [17266943] CNS Neurol Disord Drug Targets. 2007 Jun;6(3):183-92 [17511615] Pharmacol Ther. 2007 Aug;115(2):177-207 [17604107] Neuropeptides. 1999 Aug;33(4):265-70 [10657502] Trends Pharmacol Sci. 2000 Mar;21(3):109-17 [10689365] Neuropharmacology. 2000 Jun 8;39(8):1386-403 [10818255] Neuropharmacology. 2000 Jun 8;39(8):1404-12 [10818256] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00018-008-8158-3 ER - TY - JOUR T1 - Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China. AN - 69223665; 18559558 AB - Molecular events associated with the initiation and progression of esophageal squamous cell carcinoma (ESCC) remain poorly understood but likely hold the key to effective early detection approaches for this almost invariably fatal cancer. CDC25B and LAMC2 are two promising early detection candidates emerging from new molecular studies of ESCC. To further elucidate the role of these two genes in esophageal carcinogenesis, we did a series of studies to (a) confirm RNA overexpression, (b) establish the prevalence of protein overexpression, (c) relate protein overexpression to survival, and (d) explore their potential as early detection biomarkers. Results of these studies indicated that CDC25B mRNA was overexpressed (>/=2-fold overexpression in tumor compared with normal) in 64% of the 73 ESCC cases evaluated, whereas LAMC2 mRNA was overexpressed in 89% of cases. CDC25B protein expression was categorized as positive in 59% (144 of 243) of ESCC cases on a tumor tissue microarray, and nonnegative LAMC2 patterns of protein expression were observed in 82% (225 of 275) of cases. Multivariate-adjusted proportional hazard regression models showed no association between CDC25B protein expression score and risk of death [hazard ratio (HR) for each unit increase in expression score, 1.00; P = 0.90]; however, several of the LAMC2 protein expression patterns strongly predicted survival. Using the cytoplasmic pattern as the reference (the pattern with the lowest mortality), cases with a diffuse pattern had a 254% increased risk of death (HR, 3.52; P = 0.007), cases with no LAMC2 expression had a 169% increased risk of death (HR, 2.69; P = 0.009), and cases with a peripheral pattern had a 130% greater risk of death (HR, 2.30; P = 0.02). CDC25B protein expression scores in subjects with esophageal biopsies diagnosed as normal (n = 35), dysplastic (n = 23), or ESCC (n = 32) increased significantly with morphologic progression. For LAMC2, all normal and dysplastic patients had a continuous pattern of protein expression, whereas all ESCCs showed alternative, noncontinuous patterns. This series of studies showed that both CDC25B and LAMC2 overexpress RNA and protein in a significant majority of ESCC cases. The strong relation of LAMC2 pattern of protein expression to survival suggests a role in prognosis, whereas the association of CDC25B with morphologic progression indicates a potential role as an early detection marker. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Shou, Jian-Zhong AU - Hu, Nan AU - Takikita, Mikiko AU - Roth, Mark J AU - Johnson, Laura Lee AU - Giffen, Carol AU - Wang, Quan-Hong AU - Wang, Chaoyu AU - Wang, Yuan AU - Su, Hua AU - Kong, Li-Hui AU - Emmert-Buck, Michael R AU - Goldstein, Alisa M AU - Hewitt, Stephen M AU - Taylor, Philip R AD - Pathology Laboratory, Advanced Technology Center, National Cancer Institute, Bethesda, MD 20892-4605, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1424 EP - 1435 VL - 17 IS - 6 SN - 1055-9965, 1055-9965 KW - LAMC2 protein, human KW - 0 KW - Laminin KW - RNA, Messenger KW - CDC25B protein, human KW - EC 3.1.3.48 KW - cdc25 Phosphatases KW - Index Medicus KW - Protein Array Analysis KW - Gene Expression Profiling KW - Humans KW - China -- epidemiology KW - Linear Models KW - Middle Aged KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Immunoenzyme Techniques KW - Female KW - Proportional Hazards Models KW - Precancerous Conditions -- genetics KW - RNA, Messenger -- metabolism KW - Laminin -- genetics KW - Esophageal Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - cdc25 Phosphatases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69223665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Overexpression+of+CDC25B+and+LAMC2+mRNA+and+protein+in+esophageal+squamous+cell+carcinomas+and+premalignant+lesions+in+subjects+from+a+high-risk+population+in+China.&rft.au=Shou%2C+Jian-Zhong%3BHu%2C+Nan%3BTakikita%2C+Mikiko%3BRoth%2C+Mark+J%3BJohnson%2C+Laura+Lee%3BGiffen%2C+Carol%3BWang%2C+Quan-Hong%3BWang%2C+Chaoyu%3BWang%2C+Yuan%3BSu%2C+Hua%3BKong%2C+Li-Hui%3BEmmert-Buck%2C+Michael+R%3BGoldstein%2C+Alisa+M%3BHewitt%2C+Stephen+M%3BTaylor%2C+Philip+R&rft.aulast=Shou&rft.aufirst=Jian-Zhong&rft.date=2008-06-01&rft.volume=17&rft.issue=6&rft.spage=1424&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-06-0666 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-06-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1999 Nov 3;91(21):1882-7 [10547396] Science. 1997 Sep 5;277(5331):1497-501 [9278511] Int J Cancer. 2000 Mar 20;89(2):148-52 [10754492] Science. 2000 May 26;288(5470):1425-9 [10827953] Cancer Res. 2000 Jun 1;60(11):3043-50 [10850455] J Clin Invest. 2000 Sep;106(6):753-61 [10995786] Clin Cancer Res. 2000 Dec;6(12):4859-65 [11156245] Anticancer Res. 2000 Nov-Dec;20(6C):4835-40 [11205229] Am J Pathol. 2001 Mar;158(3):1129-35 [11238061] Lab Invest. 2001 Apr;81(4):465-73 [11304565] Cancer Res. 2001 Apr 1;61(7):3188-93 [11306507] Clin Cancer Res. 2001 Apr;7(4):896-900 [11309339] Cancer Lett. 2001 Jul 26;168(2):191-5 [11403924] Br J Cancer. 2001 Aug 3;85(3):412-21 [11487274] Clin Cancer Res. 2001 Aug;7(8):2213-21 [11489794] Cancer Lett. 2001 Nov 28;173(2):187-92 [11597794] Jpn J Clin Oncol. 2001 Sep;31(9):428-31 [11689596] Int J Cancer. 2001 Dec 15;94(6):763-7 [11745475] Methods. 2001 Dec;25(4):402-8 [11846609] Br J Surg. 2002 May;89(5):597-603 [11972550] Exp Hematol. 2002 Jun;30(6):503-12 [12063017] Br J Cancer. 2002 Jun 17;86(12):1909-13 [12085185] Oncogene. 2003 Feb 6;22(5):734-9 [12569365] Clin Cancer Res. 2003 May;9(5):1764-72 [12738732] Cancer Res. 2003 Jul 15;63(14):3872-6 [12873975] Cancer Res. 2003 Oct 1;63(19):6195-9 [14559803] Hum Pathol. 2004 Feb;35(2):165-75 [14991533] Natl Cancer Inst Monogr. 1982;62:113-20 [7167171] Int J Cancer. 1991 Apr 1;47(6):839-42 [2010225] Cell. 1991 Dec 20;67(6):1181-94 [1836978] J Cell Biol. 1992 Nov;119(3):679-93 [1383240] Genomics. 1993 Oct;18(1):144-7 [8276402] Nat Med. 1998 Jul;4(7):844-7 [9662379] Histopathology. 1999 Apr;34(4):305-9 [10231397] Biochem Biophys Res Commun. 1999 Jul 5;260(2):510-5 [10403798] Oncogene. 1999 Sep 16;18(37):5159-66 [10498865] Breast Cancer. 2004;11(3):295-300 [15550849] Dis Esophagus. 2004;17(4):315-21 [15569370] Oncology. 2005;69(1):71-80 [16103736] Oral Oncol. 2006 Jan;42(1):73-6 [16143562] BMC Cancer. 2006;6:296 [17187659] Matrix Biol. 1994 Apr;14(3):209-11 [7921537] Science. 1995 Sep 15;269(5230):1575-7 [7667636] J Cell Sci. 1996 May;109 ( Pt 5):1081-93 [8743955] Exp Cell Res. 1996 Nov 1;228(2):262-70 [8912719] Science. 1997 Jul 11;277(5323):225-8 [9211848] Cancer Res. 1999 Nov 1;59(21):5596-601 [10554040] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-06-0666 ER - TY - JOUR T1 - Determinants of incidence and clearance of high-risk human papillomavirus infections in rural Rakai, Uganda. AN - 69222240; 18559545 AB - We used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (HPV) infections in rural Rakai, Uganda. Women provided self-administered vaginal swab at annual home-based visits. Type-specific carcinogenic HPV incidence and clearance and risk factors were assessed. Carcinogenic HPV incidence was 17.3 per 100 person-years among HIV-positive women compared with 7.0 per 100 person-years among HIV-negative women (P < 0.001). HPV-51 had the highest incidence followed by HPV-16 (1.8 per 100 and 1.5 per 100 person-years, respectively). In multivariate model, HIV-positive women were twice as likely to have incident infection compared with HIV-negative women. Younger women were at higher risk for incident infection, as were women with higher lifetime and recent sexual partners, and high perception of AIDS. Married women were less likely to have incident infection. Approximately half of all carcinogenic HPV infections cleared over the study follow-up of 3 years. HPV-31, HPV-35, and HPV-16 had the lowest clearance (16.7%, 27.9%, and 38.3%, respectively). In multivariate model, HIV-positive, women over 30 years with higher HPV viral, burden and more lifetime sex partners were less likely to clear infections. Self-collected vaginal swabs provide accurate HPV exposure assessment for studying HPV exposure and epidemiology and can be an important tool for research in populations unwilling to undergo pelvic exam. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Safaeian, Mahboobeh AU - Kiddugavu, Mohammad AU - Gravitt, Patti E AU - Gange, Stephen J AU - Ssekasanvu, Joseph AU - Murokora, Dan AU - Sklar, Marc AU - Serwadda, David AU - Wawer, Maria J AU - Shah, Keerti V AU - Gray, Ron AD - Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. safaeianm@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1300 EP - 1307 VL - 17 IS - 6 SN - 1055-9965, 1055-9965 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Rural Population KW - Women's Health KW - Humans KW - Uganda -- epidemiology KW - Poisson Distribution KW - Genotype KW - Polymerase Chain Reaction KW - DNA, Viral -- analysis KW - Risk Factors KW - Adult KW - Vaginal Smears KW - Incidence KW - Sexually Transmitted Diseases, Viral -- epidemiology KW - Adolescent KW - Female KW - Proportional Hazards Models KW - Papillomavirus Infections -- epidemiology KW - Tumor Virus Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69222240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Determinants+of+incidence+and+clearance+of+high-risk+human+papillomavirus+infections+in+rural+Rakai%2C+Uganda.&rft.au=Safaeian%2C+Mahboobeh%3BKiddugavu%2C+Mohammad%3BGravitt%2C+Patti+E%3BGange%2C+Stephen+J%3BSsekasanvu%2C+Joseph%3BMurokora%2C+Dan%3BSklar%2C+Marc%3BSerwadda%2C+David%3BWawer%2C+Maria+J%3BShah%2C+Keerti+V%3BGray%2C+Ron&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2008-06-01&rft.volume=17&rft.issue=6&rft.spage=1300&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-07-2678 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-21 N1 - Date created - 2008-06-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Sex Transm Dis. 2007 Jul;34(7):429-36 [17075437] Ann Oncol. 2004 Jun;15(6):863-9 [15151941] Lancet. 1999 Dec 4;354(9194):1970 [10622304] JAMA. 2000 Jan 5;283(1):81-6 [10632284] CMAJ. 2000 Sep 5;163(5):513-8 [11006761] Cancer Epidemiol Biomarkers Prev. 2001 Feb;10(2):95-100 [11219778] Lancet. 2001 Jun 9;357(9271):1831-6 [11410191] J Infect Dis. 2001 Sep 15;184(6):682-90 [11517428] Am J Obstet Gynecol. 2002 Mar;186(3):365-73 [11904593] Am J Obstet Gynecol. 2002 May;186(5):962-8 [12015522] Am J Epidemiol. 2003 Feb 1;157(3):218-26 [12543621] Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):485-90 [12814991] J Natl Cancer Inst. 2003 Jul 16;95(14):1062-71 [12865452] Obstet Gynecol. 2003 Aug;102(2):266-72 [12907098] J Infect Dis. 1994 Feb;169(2):235-40 [8106758] J Natl Cancer Inst Monogr. 1996;(21):7-11 [9023823] N Engl J Med. 1997 Nov 6;337(19):1343-9 [9358128] N Engl J Med. 1998 Feb 12;338(7):423-8 [9459645] AIDS. 1998 Jul 9;12(10):1211-25 [9677171] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] IARC Sci Publ. 1998;(145):135-73 [10194635] J Infect Dis. 1999 Nov;180(5):1415-23 [10515798] J Infect Dis. 2004 Dec 15;190(12):2077-87 [15551205] J Natl Cancer Inst. 2005 Apr 20;97(8):577-86 [15840880] Gynecol Oncol. 2005 May;97(2):612-7 [15863168] Sex Transm Infect. 2005 Jun;81(3):239-41 [15923294] Clin Infect Dis. 2005 Aug 15;41(4):527-34 [16028163] Arch Pediatr Adolesc Med. 2006 Feb;160(2):151-6 [16461870] Ethn Dis. 2007 Winter;17(1):129-34 [17274222] Cancer. 2007 Jun 25;111(3):145-53 [17487850] Am J Epidemiol. 2003 Sep 1;158(5):486-94 [12936904] Int J STD AIDS. 2003 Aug;14(8):560-7 [12935387] Cancer Causes Control. 2003 Aug;14(6):505-12 [12948281] Int J Gynecol Cancer. 2003 Nov-Dec;13(6):819-26 [14675319] Obstet Gynecol. 2004 May;103(5 Pt 1):952-9 [15121570] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-07-2678 ER - TY - JOUR T1 - The prevalence of metabolic syndrome among US women of childbearing age. AN - 69210135; 18445796 AB - We sought to determine whether the prevalence of metabolic syndrome among US women of childbearing age (18-44 years) has increased since 1988 and to estimate its current prevalence by race/ethnicity and risk that a maternal history of select metabolic syndrome characteristics imposes on offspring. We used survey-specific data analysis methods to examine data from the National Health and Nutrition Examination Surveys conducted from 1988 to 2004. The prevalence of the metabolic syndrome phenotype and 2 of its clinical correlates significantly increased between 1988 and 2004 (increase for metabolic syndrome phenotype=7.6%, for obesity=13.3%, and for elevated C-reactive protein=10.6%; P < .001 for all 3). Hispanic women were more likely than were White women to possess the phenotype (P = .004). Women who reported that their mothers had been diagnosed with diabetes were more likely to possess the phenotype than those whose mothers had not been so diagnosed (odds ratio=1.9; 95% confidence interval=1.3, 2.8). The current trends of metabolic syndrome among women of childbearing age demonstrate the need for additional rigorous investigations regarding its long-term effects in these women and their offspring. JF - American journal of public health AU - Ramos, Rosemarie G AU - Olden, Kenneth AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. ramosr@niehs.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1122 EP - 1127 VL - 98 IS - 6 KW - Abridged Index Medicus KW - Index Medicus KW - Phenotype KW - Logistic Models KW - Risk Factors KW - Humans KW - Adult KW - Nutrition Surveys KW - Adolescent KW - United States -- epidemiology KW - Female KW - Prevalence KW - Metabolic Syndrome X -- epidemiology KW - Metabolic Syndrome X -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69210135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=The+prevalence+of+metabolic+syndrome+among+US+women+of+childbearing+age.&rft.au=Ramos%2C+Rosemarie+G%3BOlden%2C+Kenneth&rft.aulast=Ramos&rft.aufirst=Rosemarie&rft.date=2008-06-01&rft.volume=98&rft.issue=6&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/10.2105%2FAJPH.2007.120055 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chem. 2006 Jul;52(7):1325-30 [16675506] Diabet Med. 2006 May;23(5):469-80 [16681555] J Pediatr Gastroenterol Nutr. 2006 Oct;43(4):428-32 [17033515] Diabetes Res Clin Pract. 2007 Mar;75(3):362-5 [16930757] Circulation. 2007 Feb 6;115(5):e69-171 [17194875] Ann N Y Acad Sci. 2006 Dec;1092:138-47 [17308140] J Endocrinol Invest. 2007 Jan;30(1):70-80 [17318026] Minerva Endocrinol. 2007 Mar;32(1):35-47 [17353865] Exp Physiol. 2007 Mar;92(2):287-98 [17170060] Diabetes Care. 2001 Apr;24(4):683-9 [11315831] JAMA. 2002 Jan 16;287(3):356-9 [11790215] Circulation. 2002 Oct 1;106(14):1777-82 [12356629] Arch Intern Med. 2003 Feb 24;163(4):427-36 [12588201] Diabetes Metab. 2003 Apr;29(2 Pt 1):175-8 [12746640] Diabetes. 2003 Aug;52(8):2160-7 [12882936] Obes Res. 2003 Oct;11(10):1223-31 [14569048] J Intern Med. 2004 Feb;255(2):229-35 [14746560] J Clin Endocrinol Metab. 2004 Jun;89(6):2595-600 [15181029] Am J Prev Med. 2004 Jul;27(1):1-7 [15212768] Diabetes Care. 2004 Oct;27(10):2444-9 [15451914] Circulation. 2004 Oct 19;110(16):2494-7 [15477412] Diabetes. 1997 Oct;46(10):1594-600 [9313755] Pediatrics. 1998 Feb;101(2):E9 [9445519] J Intern Med. 1997 Jun;241(6):485-92 [10497624] Pediatrics. 2005 Mar;115(3):e290-6 [15741354] Diabetes Care. 2005 Apr;28(4):878-81 [15793189] Am J Clin Nutr. 2005 May;81(5):970-5 [15883417] Proc Nutr Soc. 2005 May;64(2):143-51 [15960859] Circulation. 2005 Oct 25;112(17):2735-52 [16157765] J Clin Endocrinol Metab. 2005 Nov;90(11):5998-6005 [16091482] Endocrinol Metab Clin North Am. 2006 Mar;35(1):137-55, vii [16310646] Am J Med Sci. 2005 Dec;330(6):290-4 [16355013] Curr Opin Cardiol. 2006 Jan;21(1):1-6 [16355022] Am J Prev Med. 2005 Dec;29(5 Suppl 1):57-62 [16389127] Diabetes. 2006 Apr;55(4):1133-40 [16567539] MMWR Recomm Rep. 2006 Apr 21;55(RR-6):1-23 [16617292] Am J Epidemiol. 2006 May 15;163(10):921-8 [16554349] Fertil Steril. 2006 Jul;86 Suppl 1:S4-5 [16798286] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2105/AJPH.2007.120055 ER - TY - JOUR T1 - An interlaboratory study of perfluorinated alkyl compound levels in human plasma. AN - 69206469; 18295197 AB - We conducted an interlaboratory study which differed from the typical study of this type because of its emphasis on comparing intralaboratory variability in results. We sent specimens to six laboratories experienced in the analysis of perfluorinated alkyl compounds in blood matrices and that use stringent procedures to control and assure accuracy and precision. Each received an identical set of 60 plasma specimens that were analyzed in six completely independent batches. Split specimens were included so that within- and between-batch coefficients of variation could be calculated. All laboratories used liquid chromatography-tandem mass spectrometry (LC-MS/MS). The concentrations of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS) measured in the specimens in general showed a high level of agreement, although in some cases the agreement was only moderate. The average within- and between-batch coefficient of variation for PFOS was 9.1% and 9.3%; for PFOA was 14.5% and 14.5%; and for PFHxS was 14.5% and 17.0%. The recent availability of labeled internal standards, among other advances, has facilitated improvement in the accuracy and precision of the assays. Considering the degree of between-subject variation in levels among people in background-exposed populations, the results indicate that biomarker-based epidemiologic studies of associations with health could have reasonable precision. JF - Environmental research AU - Longnecker, Matthew P AU - Smith, Cynthia S AU - Kissling, Grace E AU - Hoppin, Jane A AU - Butenhoff, John L AU - Decker, Emily AU - Ehresman, David J AU - Ellefson, Mark E AU - Flaherty, John AU - Gardner, Michael S AU - Langlois, Eric AU - Leblanc, Alain AU - Lindstrom, Andrew B AU - Reagen, William K AU - Strynar, Mark J AU - Studabaker, William B AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA. longnec1@niehs.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 152 EP - 159 VL - 107 IS - 2 KW - Biomarkers KW - 0 KW - Environmental Pollutants KW - Fluorocarbons KW - Index Medicus KW - Humans KW - Adult KW - Biomarkers -- blood KW - Male KW - Female KW - Pregnancy KW - Fluorocarbons -- blood KW - Environmental Monitoring -- standards KW - Environmental Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69206469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=An+interlaboratory+study+of+perfluorinated+alkyl+compound+levels+in+human+plasma.&rft.au=Longnecker%2C+Matthew+P%3BSmith%2C+Cynthia+S%3BKissling%2C+Grace+E%3BHoppin%2C+Jane+A%3BButenhoff%2C+John+L%3BDecker%2C+Emily%3BEhresman%2C+David+J%3BEllefson%2C+Mark+E%3BFlaherty%2C+John%3BGardner%2C+Michael+S%3BLanglois%2C+Eric%3BLeblanc%2C+Alain%3BLindstrom%2C+Andrew+B%3BReagen%2C+William+K%3BStrynar%2C+Mark+J%3BStudabaker%2C+William+B&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=2008-06-01&rft.volume=107&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2008.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-29 N1 - Date created - 2008-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Sci Technol. 2001 Feb 15;35(4):766-70 [11349290] Environ Health Perspect. 2007 Nov;115(11):1596-602 [18007991] Environ Sci Technol. 2002 Apr 1;36(7):146A-152A [11999053] Am J Epidemiol. 2003 Mar 15;157(6):485-92 [12631537] Environ Health Perspect. 2003 Dec;111(16):1892-901 [14644663] Regul Toxicol Pharmacol. 2004 Jun;39(3):363-80 [15135214] Environ Sci Technol. 2004 Jul 1;38(13):248A-255A [15296292] Environ Sci Technol. 2004 Sep 1;38(17):4489-95 [15461154] Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):51-6 [8118386] Environ Health Perspect. 2005 May;113(5):539-45 [15866760] Toxicology. 2005 Nov 5;215(1-2):149-69 [16129535] Environ Sci Technol. 2006 Mar 1;40(5):1447-53 [16568755] Chemosphere. 2006 Apr;63(3):490-6 [16213555] Environ Sci Technol. 2006 Jun 1;40(11):3463-73 [16786681] J Hazard Mater. 2006 Aug 25;136(3):385-91 [16759798] Environ Health Perspect. 2006 Nov;114(11):1776-82 [17107867] Environ Sci Technol. 2006 Dec 15;40(24):7854-60 [17256538] Chemosphere. 2007 May;68(1):105-11 [17267015] Environ Health Perspect. 2007 Sep;115(9):1298-305 [17805419] Lancet. 2001 Jul 14;358(9276):110-4 [11463412] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.envres.2008.01.005 ER - TY - JOUR T1 - Cancer incidence among pesticide applicators exposed to trifluralin in the Agricultural Health Study. AN - 69205743; 18342850 AB - Trifluralin, 2,6-dinitro-N,N-dipropyl-4-trifluoromethylaniline, is a 2,6-dinitro herbicide widely used to control annual grasses and broadleaf weeds in agricultural settings. The association between trifluralin use and common cancer incidence was evaluated among 50,127 private and commercial pesticide applicators in the Agricultural Health Study (AHS), a prospective cohort study of licensed pesticide applicators and their spouses in Iowa and North Carolina. Poisson regression was used to examine internal dose-response relationships, while controlling for important lifestyle factors and other agricultural exposures. Two metrics of exposure (lifetime days and intensity-weighted lifetime days) were used in exposure-response analyses with non-exposed applicators, as well as applicators in the lowest tertile of exposure, as reference groups. Incident cancers were identified through state tumor registries from enrollment in 1993 through 2002. Trifluralin exposure was not associated with cancer incidence overall among 51% of private and commercial applicators (n=25,712) who had used trifluralin. However, there was an excess of colon cancer in the exposure category of higher half of highest tertile (rate ratios (RR) of 1.76 (95% CI=1.05-2.95) using the non-exposed as a referent and 1.93 (95% CI=1.08-3.45) using those with the lowest tertile of exposure as the referent). There was also a non-significantly elevated risk for kidney cancer and bladder cancer in the highest exposure group, although only the kidney cancer finding was consistent across exposure metrics. Although there was a possible link between trifluralin exposure and colon cancer, small numbers and inconsistencies in dose-response and subgroup analyses indicate that this may be a chance finding. JF - Environmental research AU - Kang, Daehee AU - Park, Sue Kyung AU - Beane-Freeman, Laura AU - Lynch, Charles F AU - Knott, Charles E AU - Sandler, Dale P AU - Hoppin, Jane A AU - Dosemeci, Mustafa AU - Coble, Joseph AU - Lubin, Jay AU - Blair, Aaron AU - Alavanja, Michael AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd. EPS 8000, Rockville, MD 20852, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 271 EP - 276 VL - 107 IS - 2 KW - Herbicides KW - 0 KW - Trifluralin KW - C8BX46QL7K KW - Index Medicus KW - United States KW - Prospective Studies KW - Humans KW - Adult KW - Incidence KW - Middle Aged KW - Male KW - Female KW - Occupational Exposure KW - Agriculture KW - Neoplasms -- epidemiology KW - Herbicides -- toxicity KW - Trifluralin -- toxicity KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69205743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Cancer+incidence+among+pesticide+applicators+exposed+to+trifluralin+in+the+Agricultural+Health+Study.&rft.au=Kang%2C+Daehee%3BPark%2C+Sue+Kyung%3BBeane-Freeman%2C+Laura%3BLynch%2C+Charles+F%3BKnott%2C+Charles+E%3BSandler%2C+Dale+P%3BHoppin%2C+Jane+A%3BDosemeci%2C+Mustafa%3BCoble%2C+Joseph%3BLubin%2C+Jay%3BBlair%2C+Aaron%3BAlavanja%2C+Michael&rft.aulast=Kang&rft.aufirst=Daehee&rft.date=2008-06-01&rft.volume=107&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2008.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-29 N1 - Date created - 2008-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.envres.2008.01.010 ER - TY - JOUR T1 - Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders. AN - 69189949; 18449521 AB - The brain renin-angiotensin system (RAS) participates importantly in the regulation of endocrine, autonomic, and behavioral response to stress. Recent data indicate that central action of AT(1) receptor antagonists can reduce anxiety symptoms in experimental animals. Furthermore, central inhibition of RAS activity decreases ethanol intake in an animal model of alcoholism. Pathological anxiety responses and the development of substance dependence are both critically mediated through corticotrophin-releasing hormone (CRH) systems, and the RAS is positioned to interact both with hypothalamic as well as extrahypothalamic CRH systems. The thesis of this paper is that the RAS is part of the neurochemical dysregulation underlying negative affective states, anxiety disorders, and ethanol dependence and that medications targeting the RAS should be considered to augment the treatment of these disorders. JF - Journal of molecular medicine (Berlin, Germany) AU - Sommer, Wolfgang H AU - Saavedra, Juan M AD - Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1108, USA. wolfgang.sommer@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 723 EP - 728 VL - 86 IS - 6 SN - 0946-2716, 0946-2716 KW - Angiotensins KW - 0 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Index Medicus KW - Animals KW - Humans KW - Allostasis KW - Mood Disorders -- therapy KW - Brain -- metabolism KW - Alcohol-Related Disorders -- therapy KW - Angiotensins -- metabolism KW - Corticotropin-Releasing Hormone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69189949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+medicine+%28Berlin%2C+Germany%29&rft.atitle=Targeting+brain+angiotensin+and+corticotrophin-releasing+hormone+systems+interaction+for+the+treatment+of+mood+and+alcohol+use+disorders.&rft.au=Sommer%2C+Wolfgang+H%3BSaavedra%2C+Juan+M&rft.aulast=Sommer&rft.aufirst=Wolfgang&rft.date=2008-06-01&rft.volume=86&rft.issue=6&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+medicine+%28Berlin%2C+Germany%29&rft.issn=09462716&rft_id=info:doi/10.1007%2Fs00109-008-0333-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-05 N1 - Date created - 2008-05-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: FASEB J. 2005 Sep;19(11):1474-81 [16126915] Cell Mol Neurobiol. 2005 Jun;25(3-4):485-512 [16075377] CNS Neurol Disord Drug Targets. 2006 Apr;5(2):147-65 [16611089] Neuropsychopharmacology. 2006 Jun;31(6):1123-34 [16205776] Addict Biol. 2006 Mar;11(1):2-38 [16759333] Mamm Genome. 2006 Jun;17(6):669-88 [16783646] Addict Biol. 2006 Sep;11(3-4):289-309 [16961760] Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15236-41 [17015825] J Neurosci. 2006 Nov 1;26(44):11324-32 [17079660] J Neurosci. 2007 Mar 7;27(10):2718-26 [17344409] Brain Res. 2007 Apr 20;1142:92-9 [17306778] Addict Biol. 2007 Mar;12(1):30-4 [17407495] Stress. 2007 Jun;10(2):185-93 [17514587] Physiol Rev. 2007 Jul;87(3):873-904 [17615391] Trends Neurosci. 2007 Aug;30(8):399-406 [17629579] Pharmacogenomics J. 2007 Aug;7(4):222-56 [17033615] Neuropsychopharmacology. 2007 Sep;32(9):1941-9 [17287823] J Mol Med (Berl). 2007 Oct;85(10):1089-97 [17823780] Annu Rev Psychol. 2008;59:29-53 [18154498] Biol Psychiatry. 2008 Jan 15;63(2):139-45 [17585886] Stress. 2008 Nov;11(6):457-66 [18609298] FASEB J. 2001 Jul;15(9):1640-2 [11427512] Endocrinology. 2001 Sep;142(9):3880-9 [11517166] FASEB J. 2002 Jan;16(1):27-35 [11772933] J Hypertens Suppl. 2002 Jun;20(5):S13-9 [12184059] Curr Opin Investig Drugs. 2003 Jan;4(1):46-50 [12625028] Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G414-23 [12686508] J Pharmacol Exp Ther. 2004 Nov;311(2):427-40 [15297468] Med Hypotheses. 1987 Sep;24(1):11-9 [3670129] Pharmacol Biochem Behav. 1992 Jan;41(1):105-8 [1539057] Pharmacol Biochem Behav. 1993 May;45(1):35-43 [8516370] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3975-80 [10097148] Physiol Behav. 1999 Sep;67(3):369-76 [10497955] Addict Biol. 2005 Dec;10(4):309-19 [16318951] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00109-008-0333-3 ER - TY - JOUR T1 - Neuropsychological task performance in bipolar spectrum illness: genetics, alcohol abuse, medication and childhood trauma. AN - 69166469; 18452444 AB - Impaired executive and memory function is a putative genetic trait marker of bipolar I disorder (BPD I). Although executive/memory function has been posited to be an endophenotype of BPD I, it is unclear whether this extends to bipolar spectrum illness. It is also unclear to what extent non-genetic factors such as childhood abuse, alcoholism and medication influence neurocognitive function. We assessed the neuropsychological performance of a large cohort of bipolar disorder probands and their affectively ill and healthy family members, while controlling for self-reported childhood sexual and emotional abuse, emotional neglect, alcohol abuse and medication. A total of 230 largely euthymic participants from 47 families, comprising 49 subjects with BPD I, 19 with bipolar II disorder (BPD II), 44 with recurrent major depression (MDE-R), 33 with a single lifetime episode of depression (MDE-S), 20 with other DSM-IV diagnoses and 65 unaffected relatives, were assessed with a battery of neuropsychological tasks. Sexual abuse, emotional abuse and emotional neglect scores were associated with poorer cognitive performance. After controlling for childhood trauma, the BPD I group performed worse than unaffected relatives on tests of visual recall memory as well as verbal recall and recognition memory. In contrast, individuals with BPD II and bipolar spectrum illness did not differ significantly from unaffected relatives. Treatment with lithium and antipsychotic medication was associated with reduced executive and verbal recognition memory function. After controlling for medication and other covariates, only verbal recall memory was significantly impaired in the BPD I cohort. Verbal recall deficits may be one manifestation of a genetically driven dysfunction of frontal-striatal cortical networks in BPD I. JF - Bipolar disorders AU - Savitz, Jonathan B AU - van der Merwe, Lize AU - Stein, Dan J AU - Solms, Mark AU - Ramesar, Rajkumar S AD - Division of Human Genetics, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. savitzj@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 479 EP - 494 VL - 10 IS - 4 KW - Antidepressive Agents KW - 0 KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Cognition Disorders -- chemically induced KW - Child KW - Antidepressive Agents -- adverse effects KW - Family Health KW - Male KW - Female KW - Cognition Disorders -- complications KW - Child Abuse -- psychology KW - Bipolar Disorder -- drug therapy KW - Bipolar Disorder -- psychology KW - Neuropsychological Tests KW - Alcoholism -- complications KW - Bipolar Disorder -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69166469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bipolar+disorders&rft.atitle=Neuropsychological+task+performance+in+bipolar+spectrum+illness%3A+genetics%2C+alcohol+abuse%2C+medication+and+childhood+trauma.&rft.au=Savitz%2C+Jonathan+B%3Bvan+der+Merwe%2C+Lize%3BStein%2C+Dan+J%3BSolms%2C+Mark%3BRamesar%2C+Rajkumar+S&rft.aulast=Savitz&rft.aufirst=Jonathan&rft.date=2008-06-01&rft.volume=10&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Bipolar+disorders&rft.issn=1399-5618&rft_id=info:doi/10.1111%2Fj.1399-5618.2008.00591.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-07 N1 - Date created - 2008-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1399-5618.2008.00591.x ER - TY - JOUR T1 - Androgens and the molecular epidemiology of prostate cancer. AN - 69144533; 18438175 AB - Despite clinical and experimental evidence that show androgens are important in prostate carcinogenesis, epidemiologic studies of serum androgens have been inconclusive. In this review, we summarize the current state of the literature and provide insights and direction for epidemiologic research on androgens and prostate cancer. To date, data on serum androgens in prostate cancer remain inconclusive. Large studies on variants in some androgen-metabolizing genes [SRD5A2, CYP17A1, and hydroxysteroid dehydrogenase (HSD)17B1] do not show a convincing links to prostate cancer, though there are insufficient data to draw conclusions on other genes related to androgen metabolism, including UDP-glycosyltransferases (UGT), sulfotransferases (SULT), CYP3A, and estrogen-related genes. There is some evidence, although controversial, suggesting that select variants may confer risk to certain subtypes of prostate cancer. The most notable finding in 2007 is the highly reproducible link between the chromosome 8q24 risk region and prostate cancer susceptibility. Besides the link between the 8q24 region and prostate cancer risk, population studies do not convincingly show that polymorphisms in androgen metabolism genes are associated with prostate cancer risk. Large epidemiologic studies with comprehensive gene coverage and reliable exposure data are needed to clarify further the role of androgens and their related genes in prostate cancer. JF - Current opinion in endocrinology, diabetes, and obesity AU - Chu, Lisa W AU - Reichardt, Juergen Kv AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 261 EP - 270 VL - 15 IS - 3 KW - Androgens KW - 0 KW - Biomarkers, Tumor KW - Index Medicus KW - Prostate -- physiopathology KW - Biomarkers, Tumor -- genetics KW - Polymorphism, Genetic KW - Molecular Epidemiology KW - Humans KW - Genetic Predisposition to Disease -- epidemiology KW - Biomarkers, Tumor -- blood KW - Male KW - Prostatic Neoplasms -- metabolism KW - Androgens -- genetics KW - Prostatic Neoplasms -- epidemiology KW - Androgens -- blood KW - Prostatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69144533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+endocrinology%2C+diabetes%2C+and+obesity&rft.atitle=Androgens+and+the+molecular+epidemiology+of+prostate+cancer.&rft.au=Chu%2C+Lisa+W%3BReichardt%2C+Juergen+Kv%3BHsing%2C+Ann+W&rft.aulast=Chu&rft.aufirst=Lisa&rft.date=2008-06-01&rft.volume=15&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+endocrinology%2C+diabetes%2C+and+obesity&rft.issn=1752-2978&rft_id=info:doi/10.1097%2FMED.0b013e3282febcf6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-22 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/MED.0b013e3282febcf6 ER - TY - JOUR T1 - Assessment of ecological regression in the study of colon, breast, ovary, non-Hodgkin's lymphoma, or prostate cancer and residential UV. AN - 69102272; 18414201 AB - Recent ecological studies have suggested a possible association between exposure to ultraviolet-B (UVB) radiation and reduction in the risk of various cancers; however, ecological studies are known to be subject to bias. The objective of this study was to demonstrate difficulties with the ecological approach. We conducted a multicountry ecological study using cancer incidence rates, residential UV levels, dietary intake, and different sociodemographic variables for 38 locations spanning 33 countries worldwide. The effect of residential UV exposure on cancer incidence was assessed using multiple linear regression models. The results of our multivariate analyses show no indication of an inverse association between residential UV levels and the risk of colon, non-Hodgkin's lymphoma (NHL), ovarian, prostate, or breast cancer in women. For colon cancer and NHL, a significant positive association was calculated. The rates of melanoma, which were used to examine the methods of this study, showed a strong and significant (P<0.01) association with solar radiation. Our results provide no evidence to support previous ecological results that UV exposure may reduce the risk of NHL, colon, breast, ovary, or prostate cancer. The study demonstrates the high sensitivity of ecological studies to adjustments for various confounders, and casts doubts on results of ecological analyses in this field. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Waltz, Paul AU - Chodick, Gabriel AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 279 EP - 286 VL - 17 IS - 3 KW - Index Medicus KW - Ecosystem KW - Regression Analysis KW - Humans KW - Cohort Studies KW - Residence Characteristics KW - Geography KW - Male KW - Female KW - Multivariate Analysis KW - Prostatic Neoplasms -- etiology KW - Ovarian Neoplasms -- etiology KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Colonic Neoplasms -- epidemiology KW - Prostatic Neoplasms -- epidemiology KW - Colonic Neoplasms -- etiology KW - Ultraviolet Rays -- adverse effects KW - Lymphoma, Non-Hodgkin -- etiology KW - Environmental Exposure KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology KW - Ovarian Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69102272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Assessment+of+ecological+regression+in+the+study+of+colon%2C+breast%2C+ovary%2C+non-Hodgkin%27s+lymphoma%2C+or+prostate+cancer+and+residential+UV.&rft.au=Waltz%2C+Paul%3BChodick%2C+Gabriel&rft.aulast=Waltz&rft.aufirst=Paul&rft.date=2008-06-01&rft.volume=17&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=1473-5709&rft_id=info:doi/10.1097%2FCEJ.0b013e3282b6fd0f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-30 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Eur J Cancer Prev. 2008 Aug;17(4):384 [18562966] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CEJ.0b013e3282b6fd0f ER - TY - JOUR T1 - Evolutionary perspectives on psychoses and autism: Does genomic imprinting contribute to phenomenological antithesis? AN - 61691868; 200905442 AB - Crespi & Badcock (C&B) have presented a novel view that the influence of genomic imprinting causes diametrically opposite disorders: namely, psychoses and autism. I propose an extended hypothesis that while genomic imprinting is likely to have an influence on the pathogenesis of psychoses and autism, it might contribute to phenomenological antithesis between as well as within these disorders. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Venkatasubramanian, Ganesan AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, 560029, India venkat.nimhans@gmail.com Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 281 EP - 282 PB - Cambridge University Press, New York NY VL - 31 IS - 3 SN - 0140-525X, 0140-525X KW - Genetics KW - Influence KW - Psychosis KW - Autism KW - article KW - 1844: demography and human biology; human biology/sociobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61691868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=Evolutionary+perspectives+on+psychoses+and+autism%3A+Does+genomic+imprinting+contribute+to+phenomenological+antithesis%3F&rft.au=Venkatasubramanian%2C+Ganesan&rft.aulast=Venkatasubramanian&rft.aufirst=Ganesan&rft.date=2008-06-01&rft.volume=31&rft.issue=3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X08004421 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Psychosis; Autism; Genetics; Influence DO - http://dx.doi.org/10.1017/S0140525X08004421 ER - TY - JOUR T1 - The Liberty Principle and Universal Health Care AN - 58794510; 2008-183973 AB - A universal entitlement to health care can be grounded in the liberty principle. A detailed examination of Rawls's discussion of health care in Justice as Fairness shows that Rawls himself recognized that illness is a threat to the basic liberties, yet failed to recognize the implications of this fact for health resource allocation. The problem is that one cannot know how to allocate health care dollars until one knows which basic liberties one seeks to protect, and yet one cannot know which basic liberties to protect until one knows how health care dollars will be allocated. The solution is to design the list of basic liberties and the health care system in tandem so as to fit each other, such that every citizen is guaranteed a set of basic liberties and access to the health services needed to secure them. Adapted from the source document. JF - Kennedy Institute of Ethics Journal AU - Sachs, Benjamin AD - Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 149 EP - 172 PB - Johns Hopkins University Press, Baltimore MD VL - 18 IS - 2 SN - 1054-6863, 1054-6863 KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Human rights - Civil and political rights KW - Liberty KW - Health insurance KW - Health policy KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58794510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kennedy+Institute+of+Ethics+Journal&rft.atitle=The+Liberty+Principle+and+Universal+Health+Care&rft.au=Sachs%2C+Benjamin&rft.aulast=Sachs&rft.aufirst=Benjamin&rft.date=2008-06-01&rft.volume=18&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Kennedy+Institute+of+Ethics+Journal&rft.issn=10546863&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2008-10-03 N1 - Last updated - 2016-09-28 N1 - CODEN - KIEJEF N1 - SubjectsTermNotLitGenreText - Health insurance; Health policy; Public health; Liberty ER - TY - JOUR T1 - Informationist programme in support of biomedical research: a programme description and preliminary findings of an evaluation AN - 57670260; 200805834 AB - Background: The informationist programme at the Library of the National Institutes of Health (NIH) in Bethesda, MD, USA has grown to 14 informationists working with 40 clinical and basic science research teams. Purpose: This case report, intended to contribute to the literature on informationist programmes, describes the NIH informationist programme, including implementation experiences, the informationists' training programme, their job responsibilities and programme outcomes. Brief description: The NIH informationist programme was designed to enhance the library's service capacity. Over time, the steps for introducing the service to new groups were formalized to ensure support by leadership, the team being served and the library. Job responsibilities also evolved from traditional library roles to a wide range of knowledge management activities. The commitment by the informationist, the team and the library to continuous learning is critical to the programme's success. Results/outcomes: NIH scientists reported that informationists saved them time and contributed to teamwork with expert searching and point-of-need instruction. Process evaluation helped refine the programme. Evaluation method: High-level, preliminary outcomes were identified from a survey of scientists receiving informationist services, along with key informant interviews. Process evaluation examined service implementation, informationists' training and service components. Anecdotal evidence has also indicated a favourable response to the programme. Adapted from the source document. JF - Health Information and Libraries Journal AU - Whitmore, Susan C AU - Grefsheim, Suzanne F AU - Rankin, Jocelyn A AD - Information and Education Services Branch, NIH Library, US National Institutes of Health, Bethesda, MD 20892, USA whitmors@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 135 EP - 141 PB - Blackwell Publishing, Oxford UK VL - 25 IS - 2 SN - 1471-1834, 1471-1834 KW - Information services KW - National Institutes of Health KW - Medical libraries KW - Information professionals KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57670260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Information+and+Libraries+Journal&rft.atitle=Informationist+programme+in+support+of+biomedical+research%3A+a+programme+description+and+preliminary+findings+of+an+evaluation&rft.au=Whitmore%2C+Susan+C%3BGrefsheim%2C+Suzanne+F%3BRankin%2C+Jocelyn+A&rft.aulast=Whitmore&rft.aufirst=Susan&rft.date=2008-06-01&rft.volume=25&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Health+Information+and+Libraries+Journal&rft.issn=14711834&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-09-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Information services; Information professionals; Medical libraries; National Institutes of Health ER - TY - JOUR T1 - Review and special article: Psychosocial Predictors of Fruit and Vegetable Consumption in Adults A Review of the Literature AN - 57258696; 200822654 AB - Background: Adequate fruit and vegetable intake has been found to promote health and reduce the risk of several cancers and chronic diseases. Understanding the psychological determinants of fruit and vegetable intake is needed to design effective intervention programs. Methods: Papers published in English from 1994 to 2006 that described the relationship between psychosocial predictors and fruit and vegetable intake in adults were reviewed. Studies and their constructs were independently rated based on the direction of significant effects, quality of execution, design suitability, and frequency. Methodology from the Guide to Community Preventive Services was used to systematically review and synthesize findings. Results: Twenty-five psychosocial constructs spanning 35 studies were reviewed (14 prospective and 21 cross-sectional/descriptive studies). Strong evidence was found for self-efficacy, social support, and knowledge as predictors of adult fruit and vegetable intake. Weaker evidence was found for variables including barriers, intentions, attitudes/beliefs, stages of change, and autonomous motivation. Conclusions: The findings underscore the need to design future behavioral interventions that use strong experimental designs with efficacious constructs and to conduct formal mediation analyses to determine the strength of these potential predictors of fruit and vegetable intake. [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Shaikh, Abdul R AU - Yaroch, Amy L AU - Nebeling, Linda AU - Yeh, Ming-Chin AU - Resnicow, Ken AD - Health Communication and Informatics Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland shaikhab@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 535 EP - 543 PB - Elsevier Science, New York NY VL - 34 IS - 6 SN - 0749-3797, 0749-3797 KW - Vegetables KW - Predictors KW - Literature reviews KW - Fruit KW - Psychosocial factors KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57258696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Review+and+special+article%3A+Psychosocial+Predictors+of+Fruit+and+Vegetable+Consumption+in+Adults+A+Review+of+the+Literature&rft.au=Shaikh%2C+Abdul+R%3BYaroch%2C+Amy+L%3BNebeling%2C+Linda%3BYeh%2C+Ming-Chin%3BResnicow%2C+Ken&rft.aulast=Shaikh&rft.aufirst=Abdul&rft.date=2008-06-01&rft.volume=34&rft.issue=6&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.12.028 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Psychosocial factors; Health promotion; Literature reviews; Fruit; Vegetables; Predictors DO - http://dx.doi.org/10.1016/j.amepre.2007.12.028 ER - TY - JOUR T1 - Using Hand-Held Computer Technologies to Improve Dietary Intake AN - 57252593; 200820933 AB - Background: Portable hand-held information technology offers much promise not only in assessing dietary intake in the real world, but also in providing dietary feedback to individuals. However, stringent research designs have not been employed to examine whether it can be effective in modifying dietary behaviors. The purpose of this pilot study was to evaluate the efficacy of a hand-held computer (i.e., personal digital assistant [PDA]) for increasing vegetable and whole-grain intake over 8 weeks in mid-life and older adults, using a randomized study design. Methods: Twenty-seven healthy adults aged >=50 were randomized and completed the 8-week study. Intervention participants received an instructional session and a PDA programmed to monitor their vegetable and whole-grain intake levels twice per day and to provide daily individualized feedback, goal-setting, and support. Controls received standard, age-appropriate, written nutritional education materials. Dietary intake was assessed via the Block Food Frequency Questionnaire at baseline and 8 weeks. Results: Relative to controls, intervention participants reported significantly greater increases in vegetable servings (1.5-2.5 servings/day; p=0.02), as well as a trend toward greater intake of dietary fiber from grains (3.7-4.5 servings/day; p=0.10). Conclusions: This study's findings provide preliminary evidence that using portable hand-held technology to provide daily individualized feedback on dietary behavior in the real world can increase the dietary intake of healthy food groups. [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Atienza, Audie A AU - King, Abby C AU - Oliveira, Brian M AU - Ahn, David K AU - Gardner, Christopher D AD - National Cancer Institute, Division of Cancer Control and Population Sciences, Behavioral Research Program, Health Promotion Research Branch, Bethesda, Maryland Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 514 EP - 518 PB - Elsevier Science, New York NY VL - 34 IS - 6 SN - 0749-3797, 0749-3797 KW - Elderly people KW - Vegetables KW - Dietary fibre KW - Feedback KW - Information technology KW - Diet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57252593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Using+Hand-Held+Computer+Technologies+to+Improve+Dietary+Intake&rft.au=Atienza%2C+Audie+A%3BKing%2C+Abby+C%3BOliveira%2C+Brian+M%3BAhn%2C+David+K%3BGardner%2C+Christopher+D&rft.aulast=Atienza&rft.aufirst=Audie&rft.date=2008-06-01&rft.volume=34&rft.issue=6&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.01.034 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Information technology; Elderly people; Dietary fibre; Diet; Feedback; Vegetables DO - http://dx.doi.org/10.1016/j.amepre.2008.01.034 ER - TY - JOUR T1 - Randomized trials for the real world: making as few and as reasonable assumptions as possible AN - 57250757; 200816862 AB - The strength of the randomized trial to yield conclusions not dependent on assumptions applies only in an ideal setting. In the real world various complications such as loss-to-follow-up, missing outcomes, noncompliance and nonrandom selection into a trial force a reliance on assumptions. To handle real world complications, it is desirable to make as few and as reasonable assumptions as possible. This article reviews four techniques for using a few reasonable assumptions to design or analyse randomized trials in the presence of specific real world complications: 1) a double sampling design for survival data to avoid strong assumptions about informative censoring, 2) sensitivity analysis for partially missing binary outcomes that uses the randomization to reduce the number of parameters specified by the investigator, 3) an estimate of the effect of treatment received in the presence of all-or-none compliance that requires reasonable assumptions, and 4) statistics for binary outcomes that avoid some assumptions for generalizing results to a target population. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Baker, Stuart G AU - Kramer, Barnett S AD - Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 243 EP - 252 PB - Hodder Arnold, London UK VL - 17 IS - 3 SN - 0962-2802, 0962-2802 KW - Parameters KW - Statistics KW - Sensitivity analysis KW - Medical research KW - Sampling KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Randomized+trials+for+the+real+world%3A+making+as+few+and+as+reasonable+assumptions+as+possible&rft.au=Baker%2C+Stuart+G%3BKramer%2C+Barnett+S&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2008-06-01&rft.volume=17&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280207080640 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-09-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Statistics; Medical research; Parameters; Sampling; Sensitivity analysis DO - http://dx.doi.org/10.1177/0962280207080640 ER - TY - JOUR T1 - Autism Spectrum Disorder Scale Scores in Pediatric Mood and Anxiety Disorders AN - 57241765; 200816458 AB - Objective: To compare scores on autism spectrum disorder (ASD) symptom scales in healthy youths and youths with mood or anxiety disorders. Method: A total of 352 youths were recruited (107 healthy participants, 88 with an anxiety disorder, 32 with major depressive disorder, 62 with bipolar disorder, and 63 with a mood disorder characterized by severe nonepisodic irritability). Participants received structured psychiatric interviews and parent ratings on at least one of three ASD symptom scales: Children's Communication Checklist, Social Communication Questionnaire, and Social Responsiveness Scale. Results: Relative to healthy youths, youths with mood or anxiety disorders exhibited higher scores on each ASD symptom scale. ASD symptom scale scores also showed an association with impairment severity and attention-deficit/hyperactivity disorder. Among patients with mood disorders but not those with anxiety disorders, consistent, statistically significant associations between diagnosis and ASD symptom scale scores remained even after controlling for potential confounders. Conclusions: Patients with mood disorders exhibit higher scores on ASD symptom scales than healthy youths or youths with anxiety disorders. These data should alert clinicians to the importance of assessing ASD symptoms to identify social reciprocity and communication deficits as possible treatment targets in pediatric mood and anxiety disorders. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Pine, Daniel S AU - Guyer, Amanda E AU - Goldwin, Michelle AU - Towbin, Kenneth A AU - Leibenluft, Ellen AD - MAP/NIMH/NIH, 15K North Drive, Bethesda, MD 20892-2670 pined@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 652 EP - 661 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 6 SN - 0890-8567, 0890-8567 KW - mood disorder, anxiety disorder, autism spectrum, impairment KW - Anxiety disorders KW - Affective disorders KW - Moods KW - Young people KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57241765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Autism+Spectrum+Disorder+Scale+Scores+in+Pediatric+Mood+and+Anxiety+Disorders&rft.au=Pine%2C+Daniel+S%3BGuyer%2C+Amanda+E%3BGoldwin%2C+Michelle%3BTowbin%2C+Kenneth+A%3BLeibenluft%2C+Ellen&rft.aulast=Pine&rft.aufirst=Daniel&rft.date=2008-06-01&rft.volume=47&rft.issue=6&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31816bffa5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Anxiety disorders; Young people; Moods; Affective disorders; Autistic spectrum disorders DO - http://dx.doi.org/10.1097/CHI.0b013e31816bffa5 ER - TY - JOUR T1 - On improving research methodology in clinical trials AN - 57232627; 200816921 AB - Research plays a vital role within biomedicine. Scientifically appropriate research provides a basis for appropriate medical decisions; conversely, inappropriate research may lead to flawed 'best medical practices' which, when followed, contribute to avoidable morbidity and mortality. Although an all-encompassing definition of 'appropriate medical research' is beyond the scope of this article, the concept clearly entails (among other things) that research methods be continually revised and updated as better methods become available. Despite the advent of evidence-based medicine, many research methods have become 'standard' even though there are legitimate scientific reasons to question the conclusions reached by such methods. We first illustrate prominent examples of inappropriate (yet regimented) research methods that are in widespread use. Second, as a way to improve the situation, we suggest a model of research that relies on standardized statistical analyses that individual researchers must consider as a default, but are free to challenge when they can marshal sufficient scientific evidence to demonstrate that the challenge is warranted. Third, we characterize the current system as analogous to 'unnatural selection' in the biological world and argue that our proposed model of research will enable 'natural' to replace 'unnatural' selection in the choice of research methodologies. Given the pervasiveness of inappropriate research methods, we believe that there are strong scientific and ethical reasons to create such a system, that, if properly designed, will both facilitate creativity and ensure methodological rigor while protecting the public at large from the threats posed by poor medical treatment decisions resulting from flawed research methodology. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Berger, Vance W AU - Matthews, J Rosser AU - Grosch, Eric N AD - National Cancer Institute, University of Maryland, Baltimore, MD, USA Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 231 EP - 242 PB - Hodder Arnold, London UK VL - 17 IS - 3 SN - 0962-2802, 0962-2802 KW - Decision making KW - Statistics KW - Medical research KW - Clinical trials KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57232627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=On+improving+research+methodology+in+clinical+trials&rft.au=Berger%2C+Vance+W%3BMatthews%2C+J+Rosser%3BGrosch%2C+Eric+N&rft.aulast=Berger&rft.aufirst=Vance&rft.date=2008-06-01&rft.volume=17&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280207080639 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-09-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinical trials; Morbidity-Mortality; Decision making; Medical research; Statistics DO - http://dx.doi.org/10.1177/0962280207080639 ER - TY - CPAPER T1 - Staphylococcus spp: What Makes a Superbug? T2 - 108th General Meeting of the American Society for Microbiology AN - 41007197; 4886260 JF - 108th General Meeting of the American Society for Microbiology AU - Otto, M Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Ecosystems KW - Food KW - Staphylococcus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41007197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Staphylococcus+spp%3A+What+Makes+a+Superbug%3F&rft.au=Otto%2C+M&rft.aulast=Otto&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heteroresistance to Fluconazole in Cryptococcus neoformans T2 - 108th General Meeting of the American Society for Microbiology AN - 41005785; 4884811 JF - 108th General Meeting of the American Society for Microbiology AU - Sionov, E AU - Lee, H AU - Chang, Y C AU - Varma, A AU - Kwon-Chung, K J Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Fluconazole KW - Cryptococcus neoformans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Heteroresistance+to+Fluconazole+in+Cryptococcus+neoformans&rft.au=Sionov%2C+E%3BLee%2C+H%3BChang%2C+Y+C%3BVarma%2C+A%3BKwon-Chung%2C+K+J&rft.aulast=Sionov&rft.aufirst=E&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fusobacterium nucleatum ATCC10953 Requires Actinomyces naeslundii ATCC43146 for Mutualistic Growth on Saliva in a Three-Species Community with Streptococcus oralis 34 T2 - 108th General Meeting of the American Society for Microbiology AN - 41005454; 4882989 JF - 108th General Meeting of the American Society for Microbiology AU - Periasamy, S AU - Du-Thumm, L AU - Miller, S AU - Palmer Jr, R J AU - Kolenbrander, P Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Saliva KW - Growth KW - Streptococcus oralis KW - Fusobacterium nucleatum KW - Actinomyces naeslundii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Fusobacterium+nucleatum+ATCC10953+Requires+Actinomyces+naeslundii+ATCC43146+for+Mutualistic+Growth+on+Saliva+in+a+Three-Species+Community+with+Streptococcus+oralis+34&rft.au=Periasamy%2C+S%3BDu-Thumm%2C+L%3BMiller%2C+S%3BPalmer+Jr%2C+R+J%3BKolenbrander%2C+P&rft.aulast=Periasamy&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Shear Force and Conditioning Film on Oral Microbial Attachment and Detachment T2 - 108th General Meeting of the American Society for Microbiology AN - 41004718; 4883574 JF - 108th General Meeting of the American Society for Microbiology AU - Ding, A AU - Palmer Jr, R J AU - Cisar, J O AU - Kolenbrander, P E Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Corrosion KW - Biofilms KW - Biofouling KW - FliM protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41004718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Effects+of+Shear+Force+and+Conditioning+Film+on+Oral+Microbial+Attachment+and+Detachment&rft.au=Ding%2C+A%3BPalmer+Jr%2C+R+J%3BCisar%2C+J+O%3BKolenbrander%2C+P+E&rft.aulast=Ding&rft.aufirst=A&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diphthamide in Elongation Factor-2 Provides Protection to Mammalian Cells Against Ribosome Inactivating Proteins T2 - 108th General Meeting of the American Society for Microbiology AN - 41001843; 4883712 JF - 108th General Meeting of the American Society for Microbiology AU - Gupta, P K AU - Liu, S H AU - Leppla, S H Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Ribosomes KW - Mammalian cells KW - Elongation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41001843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Diphthamide+in+Elongation+Factor-2+Provides+Protection+to+Mammalian+Cells+Against+Ribosome+Inactivating+Proteins&rft.au=Gupta%2C+P+K%3BLiu%2C+S+H%3BLeppla%2C+S+H&rft.aulast=Gupta&rft.aufirst=P&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of htrB Genes in Moraxella catarrhalis Lipooligosaccharide Biosynthesis T2 - 108th General Meeting of the American Society for Microbiology AN - 40998098; 4883925 JF - 108th General Meeting of the American Society for Microbiology AU - Gao, S AU - Peng, D AU - Muszynski, A AU - Carlson, R W AU - Gu, X-X Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Biosynthesis KW - Lipooligosaccharides KW - Moraxella catarrhalis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40998098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Identification+of+htrB+Genes+in+Moraxella+catarrhalis+Lipooligosaccharide+Biosynthesis&rft.au=Gao%2C+S%3BPeng%2C+D%3BMuszynski%2C+A%3BCarlson%2C+R+W%3BGu%2C+X-X&rft.aulast=Gao&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning, Overproduction, Purification and Biochemical Characterization of the p39 Protease Domain from Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 T2 - 108th General Meeting of the American Society for Microbiology AN - 40994713; 4883662 JF - 108th General Meeting of the American Society for Microbiology AU - Zhang, D AU - Waugh, D Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Biochemistry KW - Venezuelan equine encephalitis KW - Protein purification KW - Nonstructural proteins KW - Proteinase KW - Venezuelan equine encephalitis virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Cloning%2C+Overproduction%2C+Purification+and+Biochemical+Characterization+of+the+p39+Protease+Domain+from+Venezuelan+Equine+Encephalitis+Virus+Nonstructural+Protein+2&rft.au=Zhang%2C+D%3BWaugh%2C+D&rft.aulast=Zhang&rft.aufirst=D&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Molecular Characterization of Ribitol-5-Phosphate-Containing Coaggregation Receptor Polysaccharides from Strains of Streptococcus oralis T2 - 108th General Meeting of the American Society for Microbiology AN - 40990273; 4885860 JF - 108th General Meeting of the American Society for Microbiology AU - Yang, J AU - Yoshida, Y AU - Ritchey, M AU - Bush, C A AU - Cisar, J O Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Polysaccharides KW - Strains KW - Streptococcus oralis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40990273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Comparative+Molecular+Characterization+of+Ribitol-5-Phosphate-Containing+Coaggregation+Receptor+Polysaccharides+from+Strains+of+Streptococcus+oralis&rft.au=Yang%2C+J%3BYoshida%2C+Y%3BRitchey%2C+M%3BBush%2C+C+A%3BCisar%2C+J+O&rft.aulast=Yang&rft.aufirst=J&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dot/Icm-Dependent Translocation and Subcellular Localization of Coxiella burnetii Isolate-Specific Ankyrin Repeat Proteins T2 - 108th General Meeting of the American Society for Microbiology AN - 40990123; 4885812 JF - 108th General Meeting of the American Society for Microbiology AU - Voth, D E AU - Howe, D AU - Vogel, J P AU - Unsworth, N AU - Samuel, J E AU - Heinzen, R A Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Translocation KW - Ankyrin KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40990123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Dot%2FIcm-Dependent+Translocation+and+Subcellular+Localization+of+Coxiella+burnetii+Isolate-Specific+Ankyrin+Repeat+Proteins&rft.au=Voth%2C+D+E%3BHowe%2C+D%3BVogel%2C+J+P%3BUnsworth%2C+N%3BSamuel%2C+J+E%3BHeinzen%2C+R+A&rft.aulast=Voth&rft.aufirst=D&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of C1-Hydroxyl Configuration of D-Galactose in Modulation of Gal Repressor Activity T2 - 108th General Meeting of the American Society for Microbiology AN - 40990046; 4884420 JF - 108th General Meeting of the American Society for Microbiology AU - Lee, S AU - Lewis, D E A AU - Adhya, S Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Repressors KW - D-Galactose KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40990046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Role+of+C1-Hydroxyl+Configuration+of+D-Galactose+in+Modulation+of+Gal+Repressor+Activity&rft.au=Lee%2C+S%3BLewis%2C+D+E+A%3BAdhya%2C+S&rft.aulast=Lee&rft.aufirst=S&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biological Role and Biosynthesis of PIA/PNAG in Staphylococcus epidermidis and Biofilm Detachment in PIA/PNAG-Positive Strains T2 - 108th General Meeting of the American Society for Microbiology AN - 40985981; 4886406 JF - 108th General Meeting of the American Society for Microbiology AU - Otto, M Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 KW - Biosynthesis KW - Biofilms KW - Strains KW - Staphylococcus epidermidis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40985981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Biological+Role+and+Biosynthesis+of+PIA%2FPNAG+in+Staphylococcus+epidermidis+and+Biofilm+Detachment+in+PIA%2FPNAG-Positive+Strains&rft.au=Otto%2C+M&rft.aulast=Otto&rft.aufirst=M&rft.date=2008-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=108th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={47CAD92C -66A0-4310-9655-24A3F4FB5BD5}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Generalized regression estimators of a finite population total using the Box-Cox technique AN - 37154809; 3872694 AB - ABSTRACT IN ENGLISH: A new generalized regression estimator of a finite population total based on the Box-Cox transformation technique and its variance estimator are proposed under a general unequal probability sampling design. By being design consistent, the proposed estimator maintains the robustness property of the GREG estimator even if the underlying model fails. Furthermore, the Box-Cox technique automatically finds a reasonable transformation for the dependent variable using the data. The robustness and efficiency of the new estimator are evaluated analytically and via Monte Carlo simulation studies. // ABSTRACT IN FRENCH: Un nouvel estimateur par la régression généralisée d'un total de population finie basé sur la méthode de transformation de Box-Cox et son estimateur de la variance sont proposés sous un plan général de sondage à probabilités inégales. En étant convergent par rapport au plan de sondage, l'estimateur proposé retient la propriété de robustesse de l'estimateur GREG, même si le modèle sous-jacent est défaillant. En outre, la méthode de Box-Cox permet de trouver automatiquement une transformation raisonnable de la variable dépendante en se servant des données. La robustesse et l'efficacité du nouvel estimateur sont évaluées analytiquement et par des études en simulation de Monte Carlo. Reprinted by permission of Statistics Canada. These materials are solely for non-commercial purposes. JF - Survey methodology AU - Li, Yan AD - National Cancer Institute Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 79 EP - 89 VL - 34 IS - 1 SN - 0714-0045, 0714-0045 KW - Economics KW - Research methods KW - Surveys KW - Population KW - Estimation KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37154809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Survey+methodology&rft.atitle=Generalized+regression+estimators+of+a+finite+population+total+using+the+Box-Cox+technique&rft.au=Li%2C+Yan&rft.aulast=Li&rft.aufirst=Yan&rft.date=2008-06-01&rft.volume=34&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Survey+methodology&rft.issn=07140045&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4403 7854; 9846; 12429; 7994; 10919 ER - TY - JOUR T1 - Modality-specific attention under imminent but not remote threat of shock: evidence from differential prepulse inhibition of startle AN - 37081648; 3836159 AB - Theories of animal defensive behavior postulate that imminent, predictable threat elicits highly focused attention toward the threat source, whereas remote, unpredictable threat elicits distributed attention to the overall environment. We used threat of shock combined with measurement of prepulse inhibition of the startle reflex to test these claims in humans. Twenty-seven participants experienced periods of threat and safety. Threat and safe periods were short or long, with the short threat periods conveying relatively predictable, imminent shocks and the long threat periods conveying unpredictable shocks. Startle reflexes were elicited with equal numbers of acoustic probes presented alone, preceded by a tactile prepulse, or preceded by an auditory prepulse. We observed enhanced tactile relative to auditory prepulse inhibition during short threat periods only. This finding supports the notion that imminent threat, but not remote threat, elicits attention focused toward the relevant modality, potentially reflecting preparatory activity to minimize the impact of the noxious stimulus. Reprinted by permission of Sage Publications JF - Psychological science AU - Cornwell, Brian R AU - Echiverri, Aileen M AU - Covington, Matthew F AU - Grillon, Christian AD - National Institute of Mental Health, Bethesda ; University of Washington Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 615 VL - 19 IS - 6 SN - 0956-7976, 0956-7976 KW - Sociology KW - Sociological analysis KW - Safety KW - Human behaviour KW - Threat KW - Cognitive psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37081648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+science&rft.atitle=Modality-specific+attention+under+imminent+but+not+remote+threat+of+shock%3A+evidence+from+differential+prepulse+inhibition+of+startle&rft.au=Cornwell%2C+Brian+R%3BEchiverri%2C+Aileen+M%3BCovington%2C+Matthew+F%3BGrillon%2C+Christian&rft.aulast=Cornwell&rft.aufirst=Brian&rft.date=2008-06-01&rft.volume=19&rft.issue=6&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Psychological+science&rft.issn=09567976&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11229; 2452 2449 10404; 12750; 6071 1542 11325; 11993 971 ER - TY - JOUR T1 - Antecedent characteristics of online cancer information seeking among rural breast cancer patients: an application of the cognitive-social health information processing (c-ship) model AN - 36991875; 3786291 AB - Little research has examined the antecedent characteristics of patients most likely to seek online cancer information. This study employs the Cognitive-Social Health Information Processing (C-SHIP) model as a framework to understand what psychosocial characteristics precede online cancer-related information seeking among rural breast cancer patients who often have fewer health care providers and limited local support services. Examining 144 patients who were provided free computer hardware, Internet access, and training for how to use an interactive cancer communication system, pretest survey scores indicating patients' psychosocial status were correlated with specific online cancer information seeking behaviors. Each of the factors specified by the C-SHIP model had significant relationships with online cancer information seeking behaviors, with the strongest findings emerging for cancer-relevant encodings and self-construals, cancer-relevant beliefs and expectancies, and cancer-relevant self-regulatory competencies and skills. Specifically, patients with more negative appraisals in these domains were more likely to seek out online cancer information. Additionally, antecedent variables associated with the C-SHIP model had more frequent relationships with experiential information as compared with to didactic information. This study supports the applicability of the model to discern why people afflicted with cancer may seek online information to cope with their disease. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Shaw, Bret AU - DuBenske, Lori AU - Han, Jeong Yeob AU - Cofta-Woerpel, Ludmila AU - Bush, Nigel AU - Gustafson, David AU - McTavish, Fiona AD - University of Wisconsin, Madison ; University of Georgia ; National Cancer Institute ; Center for Excellence in Cancer Communication Research, Madison Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 389 EP - 408 VL - 13 IS - 4 SN - 1081-0730, 1081-0730 KW - Sociology KW - Information KW - Communication KW - Information and communication technologies KW - Internet KW - Access to information KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36991875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Antecedent+characteristics+of+online+cancer+information+seeking+among+rural+breast+cancer+patients%3A+an+application+of+the+cognitive-social+health+information+processing+%28c-ship%29+model&rft.au=Shaw%2C+Bret%3BDuBenske%2C+Lori%3BHan%2C+Jeong+Yeob%3BCofta-Woerpel%2C+Ludmila%3BBush%2C+Nigel%3BGustafson%2C+David%3BMcTavish%2C+Fiona&rft.aulast=Shaw&rft.aufirst=Bret&rft.date=2008-06-01&rft.volume=13&rft.issue=4&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730802063546 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 2572; 6515; 518 6515; 6518; 6813 6518 DO - http://dx.doi.org/10.1080/10810730802063546 ER - TY - JOUR T1 - Bayesian selection and clustering of polymorphisms in functionally related genes AN - 36962706; 3770206 JF - Journal of the American Statistical Association AU - Dunson, David B AU - Herring, Amy H AU - Engel, Stephanie M AD - US National Institute of Environmental Health Sciences ; University of North Carolina ; Mount Sinai School of Medicine Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 534 EP - 546 VL - 103 IS - 482 SN - 0162-1459, 0162-1459 KW - Sociology KW - Genetics KW - Statistics KW - DNA KW - Regression analysis KW - Cluster analysis KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36962706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Bayesian+selection+and+clustering+of+polymorphisms+in+functionally+related+genes&rft.au=Dunson%2C+David+B%3BHerring%2C+Amy+H%3BEngel%2C+Stephanie+M&rft.aulast=Dunson&rft.aufirst=David&rft.date=2008-06-01&rft.volume=103&rft.issue=482&rft.spage=534&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214507000000554 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5460 1615 8573 11325; 2400 3279 971 3286 12224; 12228 10919; 12233; 10739 12228 10919; 3254 5460 1615 8573 11325 DO - http://dx.doi.org/10.1198/016214507000000554 ER - TY - JOUR T1 - Efficient and doubly robust imputation for covariate-dependent missing responses AN - 36962225; 3770231 JF - Journal of the American Statistical Association AU - Qin, Jing AU - Shao, Jun AU - Zhang, Biao AD - National Institutes of Health ; University of Wisconsin ; University of Toledo Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 797 EP - 810 VL - 103 IS - 482 SN - 0162-1459, 0162-1459 KW - Economics KW - Missing data KW - Data collection KW - Statistics KW - Research methods KW - Data analysis KW - Statistical methods KW - Covariance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36962225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Efficient+and+doubly+robust+imputation+for+covariate-dependent+missing+responses&rft.au=Qin%2C+Jing%3BShao%2C+Jun%3BZhang%2C+Biao&rft.aulast=Qin&rft.aufirst=Jing&rft.date=2008-06-01&rft.volume=103&rft.issue=482&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214508000000238 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12233; 3279 971 3286; 3286; 2977 13249 10214 12224 971; 10919 DO - http://dx.doi.org/10.1198/016214508000000238 ER - TY - JOUR T1 - Predictors of death or bronchopulmonary dysplasia in preterm infants with respiratory failure AN - 220381206; 18337740 AB - To identify the variables that predict death/physiologic bronchopulmonary dysplasia (BPD) in preterm infants with severe respiratory failure. The study was a secondary analysis of data from the NICHD Neonatal Research Network trial of inhaled nitric oxide (iNO) in preterm infants. Stepwise logistic regression models and Classification and Regression Tree (CART) models were developed for the outcome of death or physiologic BPD (O(2) at 36 weeks post-menstrual age). Death and/or BPD was associated with lower birth weight, higher oxygen requirement, male gender, additional surfactant doses, higher oxygenation index and outborn status, but not the magnitude of response in PaO(2) to iNO. The positive predictive value of the CART model was 82% at 95% sensitivity. The major factors associated with death/BPD were an increased severity of respiratory failure, lower birth weight, male gender and outborn status, but not the magnitude of initial response to iNO. JF - Journal of Perinatology AU - Ambalavanan, N AU - Van Meurs, K P AU - Perritt, R AU - Carlo, W A AU - Ehrenkranz, R A AU - Stevenson, D K AU - Lemons, J A AU - Poole, W K AU - Higgins, R D Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 420 EP - 6 CY - New York PB - Nature Publishing Group VL - 28 IS - 6 SN - 07438346 KW - Medical Sciences--Pediatrics KW - Logistic Models KW - Humans KW - Infant, Newborn KW - Algorithms KW - Respiratory Insufficiency -- mortality KW - Models, Statistical KW - Infant, Premature KW - Bronchopulmonary Dysplasia -- epidemiology KW - Respiratory Insufficiency -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220381206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Perinatology&rft.atitle=Predictors+of+death+or+bronchopulmonary+dysplasia+in+preterm+infants+with+respiratory+failure&rft.au=Ambalavanan%2C+N%3BVan+Meurs%2C+K+P%3BPerritt%2C+R%3BCarlo%2C+W+A%3BEhrenkranz%2C+R+A%3BStevenson%2C+D+K%3BLemons%2C+J+A%3BPoole%2C+W+K%3BHiggins%2C+R+D&rft.aulast=Ambalavanan&rft.aufirst=N&rft.date=2008-06-01&rft.volume=28&rft.issue=6&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Journal+of+Perinatology&rft.issn=07438346&rft_id=info:doi/10.1038%2Fjp.2008.18 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Jun 2008 N1 - Last updated - 2014-09-25 DO - http://dx.doi.org/10.1038/jp.2008.18 ER - TY - JOUR T1 - Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice AN - 21339236; 11722323 AB - 2-Methylimidazole (2MI) has been identified as a by-product of fermentation and is detected in foods and mainstream and side-stream tobacco smoke. It is used in the manufacture of pharmaceuticals, photographic chemicals, dyes and pigments, agricultural chemicals, and rubber. Carcinogenicity studies of 2MI were conducted because of its high potential for human exposure and a lack of carcinogenicity data. Groups of male and female Fischer 344/N rats were fed diets containing 0, 300, 1,000, or 3,000ppm (males) or 0, 1,000, 2,500, or 5,000ppm (females) 2MI for 106weeks and groups of male and female B6C3F1 mice were fed 0, 625, 1,250, or 2,500ppm 2MI for 105weeks. Animals in each group were sacrificed at 8days, 14weeks, and 6months for determinations of serum thyroid hormone and liver enzyme levels and histopathological examinations and at 2years for evaluations of neoplastic lesions. In rats, 2MI administration reduced serum thyroxine and triiodothyronine and increased thyroid stimulating hormone levels. 2MI administration also increased total hepatic UDP-glucuronosyltransferase levels. At 2years, the incidences of thyroid follicular cell hyperplasia, adenoma or carcinoma (combined), as well as follicular mineralization were increased. The incidences of hepatocellular adenoma or carcinoma (combined) in the two highest dose groups of males and females were also increased. The incidences of mixed cell focus in males and females were also significantly increased. In mice, the incidences of thyroid follicular cell hypertrophy and hyperplasia were significantly increased in the high dose males and females. The incidence of thyroid follicular cell adenoma in the 2,500ppm males was significantly greater than that in the control group. The incidences of hepatocellular adenoma or carcinoma (combined) were significantly increased in all exposed groups of males and in the 2,500ppm females. Significant increases in incidences were also observed in spleen hematopoietic cell proliferation in both sexes and bone marrow hyperplasia, chronic active inflammation of the epididymis, sperm granuloma, and germinal epithelial atrophy of the testis in males. Under these experimental conditions, carcinogenic activity of 2MI was demonstrated in male and female rats and mice. JF - Archives of Toxicology AU - Chan, P C AU - Sills, R C AU - Kissling, GE AU - Nyska, A AU - Richter, W AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA, chanp@niehs.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 399 EP - 412 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 82 IS - 6 SN - 0340-5761, 0340-5761 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Testes KW - Fermentation KW - Food KW - Bone marrow KW - Sperm KW - Mineralization KW - Thyroid hormones KW - Chronic exposure KW - Carcinogenicity KW - Pigments KW - Tobacco KW - Hepatocellular carcinoma KW - Sex KW - Data processing KW - Enzymes KW - Rubber KW - Spleen KW - Triiodothyronine KW - Granuloma KW - Carcinoma KW - Inflammation KW - Smoke KW - Hyperplasia KW - Hypertrophy KW - Liver KW - Pharmaceuticals KW - Hemopoiesis KW - Atrophy KW - Cell proliferation KW - Adenoma KW - X 24380:Social Poisons & Drug Abuse KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21339236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=Induction+of+thyroid+and+liver+tumors+by+chronic+exposure+to+2-methylimidazole+in+F344%2FN+rats+and+B6C3F1+mice&rft.au=Chan%2C+P+C%3BSills%2C+R+C%3BKissling%2C+GE%3BNyska%2C+A%3BRichter%2C+W&rft.aulast=Chan&rft.aufirst=P&rft.date=2008-06-01&rft.volume=82&rft.issue=6&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-007-0249-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Testes; Fermentation; Food; Bone marrow; Sperm; Mineralization; Thyroid hormones; Carcinogenicity; Chronic exposure; Pigments; Tobacco; Sex; Hepatocellular carcinoma; Data processing; Spleen; Rubber; Enzymes; Triiodothyronine; Granuloma; Inflammation; Carcinoma; Smoke; Hypertrophy; Hyperplasia; Liver; Hemopoiesis; Pharmaceuticals; Atrophy; Cell proliferation; Adenoma DO - http://dx.doi.org/10.1007/s00204-007-0249-7 ER - TY - JOUR T1 - Cells by Design: A Mini-Review of Targeting Cell Engineering Using DNA Microarrays AN - 21319981; 11902432 AB - Recent studies have demonstrated the utility of DNA microarray technology in engineering cellular properties. For instance, cellular adhesion, the necessity of cells to attach to a surface in order to to proliferate, was examined by comparing two distinct HeLa cell lines. Two genes, one encoding a type II membrane glycosylating sialyltransferase (siat7e) and the other encoding a secreted glycoprotein (lama4), were found to influence adhesion. The expression of siat7e correlated with reduced adhesion, whereas expression of lama4 correlated with increased adhesion, as shown by various assays. In a separate example, a gene encoding a mitochondrial assembly protein (cox15) and a gene encoding a kinase (cdkl3), were found to influence cellular growth. Enhanced expression of either gene resulted in slightly higher specific growth rates and higher maximum cell densities for HeLa, HEK-293, and CHO cell lines. Another investigated property was the adaptation of HEK-293 cells to serum-free media. The genes egr1 and gas6, both with anti-apoptotic properties, were identified as potentially improving adaptability by impacting viability at low serum levels. In trying to control apoptosis, researchers found that by altering the expression levels of four genes faim, fadd, alg-2, and requiem, apoptotic response could be altered. In the present work, these and related studies in microorganisms (prokaryote and eukaryote) are examined in greater detail focusing on the approach of using DNA microarrays to direct cellular behavior by targeting select genes. JF - Molecular Biotechnology AU - Jaluria, Pratik AU - Chu, Chia AU - Betenbaugh, Michael AU - Shiloach, Joseph AD - Biotechnology Core Laboratory, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bldg 14A Room 173, NIH, NIDDK, Bethesda, MD, 20892, USA, yossi@nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 105 EP - 111 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 39 IS - 2 SN - 1073-6085, 1073-6085 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Growth rate KW - FADD protein KW - Apoptosis KW - Adaptations KW - Cell density KW - Mitochondria KW - DNA microarrays KW - Serum levels KW - Adaptability KW - Reviews KW - Microorganisms KW - Prokaryotes KW - Glycoproteins KW - Neolactotetraosylceramide a-2,3-sialyltransferase KW - EGR-1 protein KW - W 30910:Imaging KW - N 14810:Methods KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21319981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=Cells+by+Design%3A+A+Mini-Review+of+Targeting+Cell+Engineering+Using+DNA+Microarrays&rft.au=Jaluria%2C+Pratik%3BChu%2C+Chia%3BBetenbaugh%2C+Michael%3BShiloach%2C+Joseph&rft.aulast=Jaluria&rft.aufirst=Pratik&rft.date=2008-06-01&rft.volume=39&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1007%2Fs12033-008-9048-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Growth rate; Adaptations; Apoptosis; FADD protein; Cell density; Mitochondria; DNA microarrays; Serum levels; Adaptability; Reviews; Microorganisms; Glycoproteins; Prokaryotes; EGR-1 protein; Neolactotetraosylceramide a-2,3-sialyltransferase DO - http://dx.doi.org/10.1007/s12033-008-9048-5 ER - TY - JOUR T1 - Characteristics and Outcome of Pediatric Patients Enrolled in Phase I Oncology Trials AN - 21248205; 8344992 AB - PURPOSE: To describe the characteristics of pediatric subjects who enroll in phase I trials, to determine the associations between pre-enrollment characteristics and the risk for toxicity, and to analyze response and survival outcomes. EXPERIMENTAL DESIGN: Pre-enrollment characteristics and study outcomes were retrospectively analyzed for children with refractory solid tumors treated in one of 16 phase I trials with similar eligibility criteria at the National Cancer Institute between 1992 and 2005. RESULTS: The 262 subjects analyzed had received a median of two (range, 0-9) prior chemotherapy regimens, and were on one (range, 0-12) concomitant medication. The Eastern Cooperative Oncology Group performance status scores for subjects were 0 (29%), 1 (48%), and 2 (19%); 19% had received a prior stem cell transplantation and 73% had received prior radiation. Approximately 90% of subjects were evaluable for the primary trial endpoints (toxicity and pharmacokinetics). Seventeen percent of subjects experienced a dose-limiting toxicity (DLT), 5% discontinued the study drug because of toxicity, and a drug-related death occurred in one subject (0.4%). Variables associated with a higher risk for developing a DLT, by multiple logistic regression analysis, were drug dose and prior radiation, for myelosuppressive agents, and drug dose and performance status, for nonmyelosuppressive agents. The complete and partial response rate was 4%; however, 17% of subjects had stable disease (received three or more cycles). The median overall survival time from the time of enrollment was five months. CONCLUSIONS: Primary trial objectives are achieved in approximately 90% of subjects with the standard phase I trial design and eligibility criteria despite the intensification of frontline and salvage therapies in pediatric subjects with cancer. JF - Oncologist AU - Kim, AeRang AU - Fox, Elizabeth AU - Warren, Katherine AU - Blaney, Susan M AU - Berg, Stacey L AU - Adamson, Peter C AU - Libucha, Madeleine AU - Byrley, Elena AU - Balis, Frank M AU - Widemann, Brigitte C AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA. Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 679 EP - 689 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 13 IS - 6 SN - 1083-7159, 1083-7159 KW - Toxicology Abstracts KW - Pediatrics KW - Solid tumors KW - stem cell transplantation KW - Chemotherapy KW - Survival KW - Oncology KW - Toxicity KW - Children KW - Immunosuppressive agents KW - Clinical trials KW - Pharmacokinetics KW - Cancer KW - Radiation KW - Risk factors KW - Regression analysis KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21248205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncologist&rft.atitle=Characteristics+and+Outcome+of+Pediatric+Patients+Enrolled+in+Phase+I+Oncology+Trials&rft.au=Kim%2C+AeRang%3BFox%2C+Elizabeth%3BWarren%2C+Katherine%3BBlaney%2C+Susan+M%3BBerg%2C+Stacey+L%3BAdamson%2C+Peter+C%3BLibucha%2C+Madeleine%3BByrley%2C+Elena%3BBalis%2C+Frank+M%3BWidemann%2C+Brigitte+C&rft.aulast=Kim&rft.aufirst=AeRang&rft.date=2008-06-01&rft.volume=13&rft.issue=6&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=Oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Solid tumors; Pediatrics; Chemotherapy; stem cell transplantation; Survival; Oncology; Toxicity; Children; Clinical trials; Immunosuppressive agents; Cancer; Pharmacokinetics; Radiation; Risk factors; Regression analysis; Drugs ER - TY - JOUR T1 - Neurogenesis and Exercise: Past and Future Directions AN - 21134678; 11184146 AB - Research in humans and animals has shown that exercise improves mood and cognition. Physical activity also causes a robust increase in neurogenesis in the dentate gyrus of the hippocampus, a brain area important for learning and memory. The positive correlation between running and neurogenesis has raised the hypothesis that the new hippocampal neurons may mediate, in part, improved learning associated with exercise. The present review gives an overview of research pertaining to exercise-induced cell genesis, its possible relevance to memory function and the cellular mechanisms that may be involved in this process. JF - Neuromolecular Medicine AU - van Praag, Henriette AD - Section of Neuroplasticity and Behavior, Laboratory of Neurosciences, GRC/NIA/NIH, Rm 4E14, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA, vanpraagh@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 128 EP - 140 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 10 IS - 2 SN - 1535-1084, 1535-1084 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Learning KW - Hippocampus KW - Physical activity KW - Running KW - Brain KW - Exercise KW - Dentate gyrus KW - Cognition KW - Physical training KW - Mood KW - Neurogenesis KW - Memory KW - Reviews KW - Moods KW - N3 11007:Neurobiology KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21134678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuromolecular+Medicine&rft.atitle=Neurogenesis+and+Exercise%3A+Past+and+Future+Directions&rft.au=van+Praag%2C+Henriette&rft.aulast=van+Praag&rft.aufirst=Henriette&rft.date=2008-06-01&rft.volume=10&rft.issue=2&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Neuromolecular+Medicine&rft.issn=15351084&rft_id=info:doi/10.1007%2Fs12017-008-8028-z LA - English DB - Physical Education Index N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Exercise; Learning; Memory; Running; Moods; Cognition; Brain; Neurogenesis; Physical training; Hippocampus; Reviews; Mood; Physical activity; Dentate gyrus DO - http://dx.doi.org/10.1007/s12017-008-8028-z ER - TY - JOUR T1 - Central Mechanisms of HPA Axis Regulation by Voluntary Exercise AN - 21124863; 11184145 AB - Stress exerts complex effects on the brain and periphery, dependent on the temporal profile and intensity of the stressor. The consequences of a stressful event can also be determined by other characteristics of the stressor, such as whether it is predictable and controllable. While the traditional view has focused primarily on the negative effects of stress on a variety of somatic systems, emerging data support the idea that certain forms of stress can enhance cellular function. Here we review the current literature on the hypothalamic-pituitary-adrenal (HPA) axis regulation by wheel running, a voluntary and controllable stressor with a distinct temporal profile. While running indeed activates a number of systems related to the stress response, other mechanisms exist to reduce the reactivity to this stressor, with possible crosstalk between running and other forms of stress. JF - Neuromolecular Medicine AU - Stranahan, Alexis M AU - Lee, Kim AU - Mattson, Mark P AD - Cellular and Molecular Neuroscience Section, Laboratory of Neuroscience, National Institute of Aging Intramural Research Program, Gerontology Research Center, Nathan Shock Dr, Baltimore, 5600, USA, mattsonm@grc.nia.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 118 EP - 127 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 10 IS - 2 SN - 1535-1084, 1535-1084 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Data processing KW - Running KW - Brain KW - Stress KW - Hypothalamic-pituitary-adrenal axis KW - Physical training KW - Wheel running KW - Literature reviews KW - Exercise (intensity) KW - Reviews KW - N3 11007:Neurobiology KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21124863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuromolecular+Medicine&rft.atitle=Central+Mechanisms+of+HPA+Axis+Regulation+by+Voluntary+Exercise&rft.au=Stranahan%2C+Alexis+M%3BLee%2C+Kim%3BMattson%2C+Mark+P&rft.aulast=Stranahan&rft.aufirst=Alexis&rft.date=2008-06-01&rft.volume=10&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Neuromolecular+Medicine&rft.issn=15351084&rft_id=info:doi/10.1007%2Fs12017-008-8027-0 LA - English DB - Physical Education Index N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stress; Running; Literature reviews; Exercise (intensity); Brain; Hypothalamic-pituitary-adrenal axis; Reviews; Data processing; Wheel running; Physical training DO - http://dx.doi.org/10.1007/s12017-008-8027-0 ER - TY - JOUR T1 - Executive and Attention Functioning Among Children in the PANDAS Subgroup AN - 21124016; 11153714 AB - Evidence from past studies indicates that adults and children with Obsessive-Compulsive Disorder (OCD) and Tourette syndrome (TS) experience subtle neuropsychological deficits. Less is known about neuropsychological functioning of children and adolescents with a symptom course consistent with the PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection) subgroup of OCD and tics. To provide such information, we administered three tests of attention control and two of executive function to 67 children and adolescents (ages 5-16) diagnosed with OCD and/or tics and a symptom course consistent with the PANDAS subgroup and 98 healthy volunteers (HV) matched by age, sex, and IQ. In a paired comparison of the two groups, the PANDAS subjects were less accurate than HV in a test of response suppression. Further, in a two-step linear regression analysis of the PANDAS group in which clinical variables were added stepwise into the model and in the second step matching variables (age, sex, and IQ) were added, IQ emerged as a predictor of performance on this task. In the same analysis, ADHD diagnosis and age emerged as predictors of response time in a continuous performance task. Subdividing the PANDAS group by primary psychiatric diagnosis revealed that subjects with TS or OCD with tics exhibited a longer response time compared to controls than subjects with OCD only, replicating previous findings within TS and OCD. This study demonstrates that children with PANDAS exhibit neuropsychological profiles similar to those of their primary psychiatric diagnosis. JF - Neuropsychology, Development, and Cognition. Section C: Child Neuropsychology AU - Hirschtritt, Matthew AU - Hammond, Christopher AU - Luckenbaugh, David AU - Buhle, Jason AU - Thurm, Audrey AU - Casey, B J AU - Swedo, Susan AD - Department of Health and Human Services, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA,Johns Hopkins University, Baltimore, Maryland, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 179 EP - 194 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 15 IS - 2 SN - 0929-7049, 0929-7049 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts; Immunology Abstracts KW - Streptococcus KW - Age KW - Pediatrics KW - Adolescence KW - Infection KW - Children KW - Cognition KW - Executive function KW - Intelligence KW - Mental disorders KW - Regression analysis KW - Obsessive compulsive disorder KW - Gilles de la Tourette syndrome KW - Sex KW - N3 11001:Behavioral and Cognitive Neuroscience KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21124016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychology%2C+Development%2C+and+Cognition.+Section+C%3A+Child+Neuropsychology&rft.atitle=Executive+and+Attention+Functioning+Among+Children+in+the+PANDAS+Subgroup&rft.au=Hirschtritt%2C+Matthew%3BHammond%2C+Christopher%3BLuckenbaugh%2C+David%3BBuhle%2C+Jason%3BThurm%2C+Audrey%3BCasey%2C+B+J%3BSwedo%2C+Susan&rft.aulast=Hirschtritt&rft.aufirst=Matthew&rft.date=2008-06-01&rft.volume=15&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Neuropsychology%2C+Development%2C+and+Cognition.+Section+C%3A+Child+Neuropsychology&rft.issn=09297049&rft_id=info:doi/10.1080%2F09297040802186899 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Pediatrics; Adolescence; Children; Infection; Cognition; Executive function; Intelligence; Mental disorders; Regression analysis; Obsessive compulsive disorder; Gilles de la Tourette syndrome; Sex; Streptococcus DO - http://dx.doi.org/10.1080/09297040802186899 ER - TY - JOUR T1 - A Frailty Mixture Cure Model with Application to Hospital Readmission Cata AN - 21123151; 11158217 AB - Mixture cure models have been utilized to analyze survival data with possible cure. This paper considers the inclusion of frailty into the mixture cure model to model recurrent event data with a cure fraction. An attractive feature of the proposed model is the allowance for heterogeneity in risk among those individuals experiencing the event of interest in addition to the incorporation of a cured component. Maximum likelihood estimates can be obtained using the Expectation Maximization algorithm and standard errors are calculated from the Bootstrap method. The model is applied to hospital readmission data among colorectal cancer patients. JF - Biometrical Journal AU - Yu, Binbing AD - Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Gateway Building, Suite 3C309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA, yubi@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 386 EP - 394 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 3 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Data processing KW - Algorithms KW - Survival KW - Biometrics KW - Hospitals KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21123151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=A+Frailty+Mixture+Cure+Model+with+Application+to+Hospital+Readmission+Cata&rft.au=Yu%2C+Binbing&rft.aulast=Yu&rft.aufirst=Binbing&rft.date=2008-06-01&rft.volume=50&rft.issue=3&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200710399 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Hospitals; Algorithms; Biometrics; Statistics; Survival DO - http://dx.doi.org/10.1002/bimj.200710399 ER - TY - JOUR T1 - Investigation of an outbreak of device-related postoperative ventriculitis: A lesson learnt AN - 21106040; 11328599 AB - Pseudomonas aeruginosa (P aeruginosa) is one of the most common nosocomial pathogens. We report our experience of a device-related outbreak of postoperative ventriculitis caused by P aeruginosa thus initiating investigation of the unusual occurrence. Five neurosurgical patients were affected, postoperatively. The investigations entailed extensive screening of the common sources of contamination for colonization of P aeruginosa. Sterilized instruments used for surgery, including the ultrasonic aspirator (USA) sets and other hollow devices, were randomly sampled and cultured. Conventional culture methods yielded P aeruginosa, with almost similar antibiotic sensitivity pattern in all the patients and the ultrasonic aspirator, clinching the source of contamination. Routine surveillance, identification of unusual patterns, molecular epidemiological typing would be helpful in quick control of outbreaks of postoperative infections. JF - Indian Journal of Pathology and Microbiology AU - Kumari, HBV AU - Nagarathna, S AU - Chandramouli, BA AU - Rao, GSU AU - Chandramuki, A AD - Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences (MMHANS), Bangalore - 560 029, Karnataka, India Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 301 EP - 303 VL - 51 IS - 2 SN - 0377-4929, 0377-4929 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Postoperative infection KW - Contamination KW - Ventriculitis KW - Antibiotics KW - Pathogens KW - Neurosurgery KW - Colonization KW - Typing KW - Ultrasonics KW - Surgery KW - Pseudomonas aeruginosa KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21106040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Pathology+and+Microbiology&rft.atitle=Investigation+of+an+outbreak+of+device-related+postoperative+ventriculitis%3A+A+lesson+learnt&rft.au=Kumari%2C+HBV%3BNagarathna%2C+S%3BChandramouli%2C+BA%3BRao%2C+GSU%3BChandramuki%2C+A&rft.aulast=Kumari&rft.aufirst=HBV&rft.date=2008-06-01&rft.volume=51&rft.issue=2&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Pathology+and+Microbiology&rft.issn=03774929&rft_id=info:doi/10.4103%2F0377-4929.41697 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Postoperative infection; Colonization; Typing; Contamination; Ultrasonics; Surgery; Ventriculitis; Antibiotics; Pathogens; Neurosurgery; Hospitals; Pseudomonas aeruginosa DO - http://dx.doi.org/10.4103/0377-4929.41697 ER - TY - JOUR T1 - Youden Index and Optimal Cut-Point Estimated from Observations Affected by a Lower Limit of Detection AN - 21079326; 11133028 AB - The receiver operating characteristic (ROC) curve is used to evaluate a biomarker's ability for classifying disease status. The Youden Index (J), the maximum potential effectiveness of a biomarker, is a common summary measure of the ROC curve. In biomarker development, levels may be unquantifiable below a limit of detection (LOD) and missing from the overall dataset. Disregarding these observations may negatively bias the ROC curve and thus J. Several correction methods have been suggested for mean estimation and testing; however, little has been written about the ROC curve or its summary measures. We adapt non-parametric (empirical) and semi-parametric (ROC-GLM [generalized linear model]) methods and propose parametric methods (maximum likelihood (ML)) to estimate J and the optimal cut-point (c *) for a biomarker affected by a LOD. We develop unbiased estimators of J and c * via ML for normally and gamma distributed biomarkers. Alpha level confidence intervals are proposed using delta and bootstrap methods for the ML, semi-parametric, and non-parametric approaches respectively. Simulation studies are conducted over a range of distributional scenarios and sample sizes evaluating estimators' bias, root-mean square error, and coverage probability; the average bias was less than one percent for ML and GLM methods across scenarios and decreases with increased sample size. An example using polychlorinated biphenyl levels to classify women with and without endometriosis illustrates the potential benefits of these methods. We address the limitations and usefulness of each method in order to give researchers guidance in constructing appropriate estimates of biomarkers' true discriminating capabilities. JF - Biometrical Journal AU - Ruopp, Marcus D AU - Perkins, Neil J AU - Whitcomb, Brian W AU - Schisterman, Enrique F AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, 6100 Executive Blvd, 7B03, Rockville Bethesda, MD, USA, schistee@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 419 EP - 430 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 3 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - polychlorinated biphenyls KW - Endometriosis KW - biomarkers KW - PCB KW - Models KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21079326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Youden+Index+and+Optimal+Cut-Point+Estimated+from+Observations+Affected+by+a+Lower+Limit+of+Detection&rft.au=Ruopp%2C+Marcus+D%3BPerkins%2C+Neil+J%3BWhitcomb%2C+Brian+W%3BSchisterman%2C+Enrique+F&rft.aulast=Ruopp&rft.aufirst=Marcus&rft.date=2008-06-01&rft.volume=50&rft.issue=3&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200710415 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - biomarkers; PCB; Endometriosis; polychlorinated biphenyls; Models DO - http://dx.doi.org/10.1002/bimj.200710415 ER - TY - JOUR T1 - Alcohol exposure on postnatal day 5 induces Purkinje cell loss and evidence of Purkinje cell degradation in lobule I of rat cerebellum AN - 21061403; 8602121 AB - The reduction in neuron number in specific brain regions is one of the most destructive aspects of alcohol-induced developmental brain injury, and its occurrence depends on the timing, pattern, and dose of maternal alcohol consumption during pregnancy. The purpose of this investigation was to quantify the dose-response aspect of Purkinje cell loss and rapid cellular degradation indicative of Purkinje cell loss following a single alcohol exposure on postnatal day 5 in lobule I, a lobule that has been shown to be vulnerable to alcohol-induced injury during cerebellar development. Fluoro- Jade B was used to identify Purkinje cell degeneration in 2-h intervals during the first 24 h following the single alcohol exposure. At the end of 24 h, stereology cell counting techniques were used to estimate the number of Purkinje cells in lobule I of the cerebellum. Significant Fluoro-Jade B labeling of lobule I Purkinje cells began at 12-h postexposure in the 6.0- g/kg group with continued significant expression of the marker at the 16- and 18-h time points. Notably, the magnitude of Fluoro-Jade B expression in the 6.0-g/kg group remained high during the period between 12 and 24 h even though the difference between the 6.0-g/kg group and other groups did not reach statistical significance at the 14-, 20-, and 24-h time points. On postnatal day 6, 24 h following the alcohol exposure, rats exposed to the highest alcohol dose (6.0 g/kg) had lost significantly more Purkinje cells than those in the nutritional or caloric control to the highest dose of alcohol group. These results are suggestive of a unique relationship among the quantity of alcohol, the onset and duration of cell degradation, and the degree of eventual cell loss. Given that cerebellar Purkinje cells (and many developing neurons) are vulnerable to alcohol-induced neuronal loss within hours of a single alcohol insult, women should be counseled to avoid drinking alcohol in a manner that significantly increases blood alcohol levels during pregnancy (e.g., binge drinking). JF - Alcohol AU - Lee, Youngki AU - Rowe, Julie AU - Eskue, Kyle AU - West, James R AU - Maier, Susan E AD - Department of Histology, College of Medicine, Cheju National University, Jeju-si-690-756, Republic of Korea, maiers@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 295 EP - 302 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 42 IS - 4 SN - 0741-8329, 0741-8329 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Fetal alcohol syndrome KW - Third trimester KW - Cell death KW - Ethanol KW - Stereology KW - Fluoro-Jade B KW - Blood KW - Brain injury KW - Statistics KW - Neurons KW - Purkinje cells KW - Cerebellum KW - Drinking behavior KW - Enumeration KW - Neurodegeneration KW - Pregnancy KW - X 24380:Social Poisons & Drug Abuse KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21061403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Alcohol+exposure+on+postnatal+day+5+induces+Purkinje+cell+loss+and+evidence+of+Purkinje+cell+degradation+in+lobule+I+of+rat+cerebellum&rft.au=Lee%2C+Youngki%3BRowe%2C+Julie%3BEskue%2C+Kyle%3BWest%2C+James+R%3BMaier%2C+Susan+E&rft.aulast=Lee&rft.aufirst=Youngki&rft.date=2008-06-01&rft.volume=42&rft.issue=4&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2008.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Blood; Statistics; Brain injury; Neurons; Cerebellum; Purkinje cells; Drinking behavior; Enumeration; Neurodegeneration; Pregnancy; Ethanol DO - http://dx.doi.org/10.1016/j.alcohol.2008.01.010 ER - TY - JOUR T1 - The Chlamydia trachomatis Plasmid Is a Transcriptional Regulator of Chromosomal Genes and a Virulence Factor AN - 21027469; 8198752 AB - Chlamydia trachomatis possesses a cryptic 7.5-kb plasmid of unknown function. Here, we describe a comprehensive molecular and biological characterization of the naturally occurring plasmidless human C. trachomatis strain L2(25667R). We found that despite minimal chromosomal polymorphisms, the LGV strain L2(25667R) was indistinguishable from plasmid-positive strain L2(434) with regard to its in vitro infectivity characteristics such as growth kinetics, plaquing efficiency, and plaque size. The only in vitro phenotypic differences between L2(434) and L2(25667R) were the accumulation of glycogen granules in the inclusion matrix and the lack of the typical intrainclusion Brownian-like movement characteristic of C. trachomatis strains. Conversely, we observed a marked difference between the two strains in their abilities to colonize and infect the female mouse genital tract. The 50% infective dose of plasmidless strain L2(25667R) was 400-fold greater (4 x 10 super(6) inclusion-forming units [IFU]) than that of plasmid-bearing strain L2(434) (1 x 10 super(4) IFU). Transcriptome analysis of the two strains demonstrated a decrease in the transcript levels of a subset of chromosomal genes for strain L2(25667R). Among those genes was glgA, encoding glycogen synthase, a finding consistent with the failure of L2(25667R) to accumulate glycogen granules. These findings support a primary role for the plasmid in in vivo infectivity and suggest that virulence is controlled, at least in part, by the plasmid's ability to regulate the expression of chromosomal genes. Our findings have important implications in understanding a role for the plasmid in the pathogenesis of human infection and disease. JF - Infection and Immunity AU - Carlson, John H AU - Whitmire, William M AU - Crane, Deborah D AU - Wicke, Luke AU - Virtaneva, Kimmo AU - Sturdevant, Daniel E AU - Kupko, John JIII AU - Porcella, Stephen F AU - Martinez-Orengo, Neysha AU - Heinzen, Robert A AU - Kari, Laszlo AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites. Genomics Unit Research Technologies Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 2273 EP - 2283 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 6 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Granules KW - virulence factors KW - Chlamydia trachomatis KW - Transcription KW - Glycogen synthase KW - Infection KW - Plasmids KW - Glycogen KW - Gene expression KW - Infectivity KW - Kinetics KW - Inclusion bodies KW - Genital tract KW - Plaques KW - J 02410:Animal Diseases KW - A 01490:Miscellaneous KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21027469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Chlamydia+trachomatis+Plasmid+Is+a+Transcriptional+Regulator+of+Chromosomal+Genes+and+a+Virulence+Factor&rft.au=Carlson%2C+John+H%3BWhitmire%2C+William+M%3BCrane%2C+Deborah+D%3BWicke%2C+Luke%3BVirtaneva%2C+Kimmo%3BSturdevant%2C+Daniel+E%3BKupko%2C+John+JIII%3BPorcella%2C+Stephen+F%3BMartinez-Orengo%2C+Neysha%3BHeinzen%2C+Robert+A%3BKari%2C+Laszlo%3BCaldwell%2C+Harlan+D&rft.aulast=Carlson&rft.aufirst=John&rft.date=2008-06-01&rft.volume=76&rft.issue=6&rft.spage=2273&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Granules; virulence factors; Transcription; Glycogen synthase; Plasmids; Infection; Glycogen; Gene expression; Infectivity; Kinetics; Inclusion bodies; Plaques; Genital tract; Chlamydia trachomatis ER - TY - JOUR T1 - Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates AN - 21026688; 8198758 AB - Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the targeting of metabolic processes to shorten drug regimens. Pimonidazole hydrochloride (Hypoxyprobe) is an imaging agent that is bioreductively activated only under hypoxic conditions in mammalian tissue. We employed this probe to evaluate the oxygen tension in tuberculous granulomas in four animal models of disease: mouse, guinea pig, rabbit, and nonhuman primate. Following infusion of pimonidazole into animals with established infections, lung tissues from the guinea pig, rabbit, and nonhuman primate showed discrete areas of pimonidazole adduct formation surrounding necrotic and caseous regions of pulmonary granulomas by immunohistochemical staining. This labeling could be substantially reduced by housing the animal under an atmosphere of 95% O sub(2). Direct measurement of tissue oxygen partial pressure by surgical insertion of a fiber optic oxygen probe into granulomas in the lungs of living infected rabbits demonstrated that even small (3-mm) pulmonary lesions were severely hypoxic (1.6 plus or minus 0.7 mm Hg). Finally, metronidazole, which has potent bactericidal activity in vitro only under low-oxygen culture conditions, was highly effective at reducing total-lung bacterial burdens in infected rabbits. Thus, three independent lines of evidence support the hypothesis that hypoxic microenvironments are an important feature of some lesions in these animal models of tuberculosis. JF - Infection and Immunity AU - Via, Laura E AU - Lin, PLing AU - Ray, Sonja M AU - Carrillo, Jose AU - Allen, Shannon Sedberry AU - Eum, Seok Yong AU - Taylor, Kimberly AU - Klein, Edwin AU - Manjunatha, Ujjini AU - Gonzales, Jacqueline AU - Lee, Eun Gae AU - Park, Seung Kyu AU - Raleigh, James A AU - Cho, Sang Nae AU - McMurray, David N AU - Flynn, JoAnne L AU - Barry, Clifton EIII AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda. Comparative Medicine Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland. Department of Pediatrics, Children's Hospital of Pittsburgh. Department of Molecular Genetics and Biochemistry. Division of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. College of Medicine, Texas A&M University System Health Science Center, College Station, Texas. International Tuberculosis Research Center. National Masan Tuberculosis Hospital, Ministry of Health and Welfare, Masan. Department of Microbiology, Yonsei University College of Medicine, Seoul, South Korea. Department of Radiobiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 2333 EP - 2340 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 6 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Metronidazole KW - Physical characteristics KW - Oxygen tension KW - Housing KW - Adducts KW - Probes KW - Animal models KW - Infection KW - Granuloma KW - Primates KW - imaging KW - Atmosphere KW - Fibers KW - Lung KW - Hypoxia KW - Microenvironments KW - Tuberculosis KW - Pressure KW - Drugs KW - Bactericidal activity KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21026688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Tuberculous+Granulomas+Are+Hypoxic+in+Guinea+Pigs%2C+Rabbits%2C+and+Nonhuman+Primates&rft.au=Via%2C+Laura+E%3BLin%2C+PLing%3BRay%2C+Sonja+M%3BCarrillo%2C+Jose%3BAllen%2C+Shannon+Sedberry%3BEum%2C+Seok+Yong%3BTaylor%2C+Kimberly%3BKlein%2C+Edwin%3BManjunatha%2C+Ujjini%3BGonzales%2C+Jacqueline%3BLee%2C+Eun+Gae%3BPark%2C+Seung+Kyu%3BRaleigh%2C+James+A%3BCho%2C+Sang+Nae%3BMcMurray%2C+David+N%3BFlynn%2C+JoAnne+L%3BBarry%2C+Clifton+EIII&rft.aulast=Via&rft.aufirst=Laura&rft.date=2008-06-01&rft.volume=76&rft.issue=6&rft.spage=2333&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Metronidazole; Physical characteristics; Housing; Oxygen tension; Adducts; Animal models; Probes; Granuloma; Infection; Atmosphere; imaging; Fibers; Lung; Hypoxia; Microenvironments; Tuberculosis; Pressure; Bactericidal activity; Drugs; Primates; Mycobacterium tuberculosis ER - TY - JOUR T1 - Cisplatin enhances the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand gene therapy via recruitment of the mitochondria- dependent death signaling pathway AN - 20940987; 8230590 AB - Despite adequately expressing tumor necrosis factor-related apoptosis- inducing ligand (TRAIL) receptors DR4/DR5, malignant cells are frequently refractory to the cytotoxic effect of this apoptosis-inducing ligand. The susceptibility of cancer cells to TRAIL can be potentiated by cisplatin (CDDP). This study was designed to evaluate the ability of cisplatin to enhance the cytotoxic effect of TRAIL gene therapy using the recombinant adenovirus-mediated tumor-selective expression of membrane-bound green fluorescence protein (GFP)-TRAIL fusion protein (AdVgTRAIL) on thoracic cancer cells and to elucidate the putative mechanisms responsible for this synergistic combination effect. While causing little death of cultured thoracic cancer cells by itself, AdVgTRAIL in combination with CDDP, on the other hand, mediated profound supra-additive cytotoxicity and apoptosis via a strong bystander effect. CDDP/AdVgTRAIL-induced cytotoxicity was completely abrogated either by the pancaspase inhibitor zVAD-fmk or by the selective caspase 9 inhibitor or by transient knockdown of caspase 9 by siRNA, indicating that this process was caspase-mediated and mitochondria-dependent. This was confirmed by the observation that Bcl2 overexpression protected the cells from combination-induced cytotoxicity. Robust activation of caspase 8 activity in combination-treated cells was blocked by overexpression of Bcl2, indicating that caspase 8 activation was secondary to the mitochondria- mediated amplification feedback loop. Combining CDDP with AdVgTRAIL greatly enhances its tumoricidal efficacy in cultured thoracic cancer cells in vitro. The two agents interact to mediate profound activation of caspase cascade via recruitment of the mitochondria and positive feedback loop. The CDDP/AdVgTRAIL combination also exhibits a strong antitumor effect in in vivo animal model of human cancer xenografts. JF - Cancer Gene Therapy AU - Shamimi-Noori, S AU - Yeow, W-S AU - Ziauddin, M F AU - Xin, H AU - Tran, T L N AU - Xie, J AU - Loehfelm, A AU - Patel, P AU - Yang, J AU - Schrump, D S AU - Fang, B L AU - Nguyen, D M AD - Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, dnguyen4@med.miami.edu Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 356 EP - 370 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 6 SN - 0929-1903, 0929-1903 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - adenovirus KW - lung cancer KW - mesothelioma KW - esophageal cancer KW - TRAIL KW - mitochondria AdVgTRAIL KW - replication-defective adenovirus expressing GFP-TRAIL gene under hTERT promoter KW - GFP KW - green fluorescence protein KW - tumor necrosis factor-related apoptosis-inducing ligand KW - CMV KW - cytomegalovirus KW - LacZ KW - [beta]-galactosidase gene KW - MTT KW - (4,5-dimethylthiazo-2-yl)-2,5-diphenyl tetrazolium bromide KW - Caspase-9 KW - Fluorescence KW - Apoptosis KW - Gene therapy KW - Caspase-8 KW - Animal models KW - Mitochondria KW - Cancer KW - Cytotoxicity KW - siRNA KW - Cisplatin KW - Thorax KW - Feedback KW - Xenografts KW - Fusion protein KW - TRAIL protein KW - Antitumor activity KW - Signal transduction KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20940987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Gene+Therapy&rft.atitle=Cisplatin+enhances+the+antitumor+effect+of+tumor+necrosis+factor-related+apoptosis-inducing+ligand+gene+therapy+via+recruitment+of+the+mitochondria-+dependent+death+signaling+pathway&rft.au=Shamimi-Noori%2C+S%3BYeow%2C+W-S%3BZiauddin%2C+M+F%3BXin%2C+H%3BTran%2C+T+L+N%3BXie%2C+J%3BLoehfelm%2C+A%3BPatel%2C+P%3BYang%2C+J%3BSchrump%2C+D+S%3BFang%2C+B+L%3BNguyen%2C+D+M&rft.aulast=Shamimi-Noori&rft.aufirst=S&rft.date=2008-06-01&rft.volume=15&rft.issue=6&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fsj.cgt.7701120 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Caspase-9; Apoptosis; Fluorescence; Gene therapy; Caspase-8; Animal models; Mitochondria; Cancer; Cytotoxicity; Cisplatin; siRNA; Thorax; Feedback; Fusion protein; Xenografts; TRAIL protein; Signal transduction; Antitumor activity DO - http://dx.doi.org/10.1038/sj.cgt.7701120 ER - TY - JOUR T1 - Saccharides cross-reactive with Bacillus anthracis spore glycoprotein as an anthrax vaccine component AN - 20922749; 8343496 AB - Bacillus anthracis is a spore-forming bacterium that causes anthrax in humans and in other mammals. The glycoprotein BclA (Bacillus collagen-like protein of anthracis) is a major constituent of the exosporium, the outermost surface of B. anthracis spores. The glycosyl part of BclA is an oligosaccharide composed of 2-O-methyl-4-(3-hydroxy-3-methylbutanamido)-4,6-dideoxy-D-glucose, referred to as anthrose, and three rhamnose residues. A structure similar to anthrose, 4-(3-hydroxy-3-methylbutanamido)-4,6-dideoxy-D-glucose is found in the side chain of the capsular polysaccharide (CPS) of Shewanella spp. MR-4. Under certain growth conditions the bacteria produce a variant CPS lacking one methyl group on the hydroxybutyrate, 4-(3-hydroxybutanamido)-4,6-dideoxy-D-glucose. Contrary to anthrose, neither of the Shewanella CPSs is 2-O methylated. Here, we report that both Shewanella CPS variants react with anti-B. anthracis spore sera. We also found that these antisera reacted with flagellae of Pseudomonas syringae, reported to be glycosylated with a similar terminal saccharide, 4-(3-hydroxybutanamido)-4,6-dideoxy-2-O-methyl-D-glucose. Sera produced by immunization with Shewanella or P. syringae cells bound to B. anthracis spores but not to Bacillus cereus spores in a fluorescent microscopy assay. These experiments show that methylation of the anthrose at the O-2 of the sugar ring and at the C-3 of 3-hydroxybutyrate are not essential for induction of cross-reactive antibodies. We report the preparation, characterization, and antibody responses to protein conjugates of the two variants of Shewanella CPS. Both conjugates induced antibodies that bound to both Shewanella CPS variants by ELISA and to B. anthracis spores, as detected by fluorescent microscopy. We propose the use of Shewanella CPS conjugates as a component of an anthrax vaccine. JF - Proceedings of the National Academy of Sciences, USA AU - Kubler-Kielb, Joanna AU - Vinogradov, Evgeny AU - Hu, Haijing AU - Leppla, Stephen H AU - Robbins, John B AU - Schneerson, Rachel AD - National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 8709 EP - 8712 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 25 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Sugar KW - Enzyme-linked immunosorbent assay KW - oligosaccharides KW - Lymphocytes B KW - Growth conditions KW - Bacillus cereus KW - Bacillus anthracis KW - Shewanella KW - Immunization KW - Collagen KW - Antisera KW - Antibodies KW - Microscopy KW - Anthrax KW - Glycoproteins KW - Vaccines KW - Spores KW - Capsular polysaccharides KW - Methylation KW - Pseudomonas syringae KW - Rhamnose KW - N 14820:DNA Metabolism & Structure KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20922749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Saccharides+cross-reactive+with+Bacillus+anthracis+spore+glycoprotein+as+an+anthrax+vaccine+component&rft.au=Kubler-Kielb%2C+Joanna%3BVinogradov%2C+Evgeny%3BHu%2C+Haijing%3BLeppla%2C+Stephen+H%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Kubler-Kielb&rft.aufirst=Joanna&rft.date=2008-06-01&rft.volume=105&rft.issue=25&rft.spage=8709&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sugar; Enzyme-linked immunosorbent assay; oligosaccharides; Growth conditions; Lymphocytes B; Immunization; Collagen; Antibodies; Antisera; Microscopy; Anthrax; Vaccines; Glycoproteins; Spores; Methylation; Capsular polysaccharides; Rhamnose; Bacillus cereus; Bacillus anthracis; Shewanella; Pseudomonas syringae ER - TY - JOUR T1 - Local Adaptation and Vector-Mediated Population Structure in Plasmodium vivax Malaria AN - 20909832; 8202232 AB - Plasmodium vivax in southern Mexico exhibits different infectivities to 2 local mosquito vectors, Anopheles pseudopunctipennis and Anopheles albimanus. Previous work has tied these differences in mosquito infectivity to variation in the central repeat motif of the malaria parasite's circumsporozoite (csp) gene, but subsequent studies have questioned this view. Here we present evidence that P. vivax in southern Mexico comprised 3 genetic populations whose distributions largely mirror those of the 2 mosquito vectors. Additionally, laboratory colony feeding experiments indicate that parasite populations are most compatible with sympatric mosquito species. Our results suggest that reciprocal selection between malaria parasites and mosquito vectors has led to local adaptation of the parasite. Adaptation to local vectors may play an important role in generating population structure in PLASMODIUM: A better understanding of coevolutionary dynamics between sympatric mosquitoes and parasites will facilitate the identification of molecular mechanisms relevant to disease transmission in nature and provide crucial information for malaria control. JF - Molecular Biology and Evolution AU - Joy, Deirdre A AU - Gonzalez-Ceron, Lilia AU - Carlton, Jane M AU - Gueye, Amy AU - Fay, Michael AU - McCutchan, Thomas F AU - Su, Xin-zhuan AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. Instituto Nacional de Salud Publica, Chiapas State, Mexico. Department of Medical Parasitology, New York University School of Medicine. Hood College. Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1245 EP - 1252 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk] VL - 25 IS - 6 SN - 0737-4038, 0737-4038 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts; Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Molecular modelling KW - Parasites KW - Human diseases KW - Plasmodium vivax KW - Malaria KW - CSP gene KW - Hosts KW - Anopheles albimanus KW - Disease transmission KW - Public health KW - circumsporozoite protein KW - Population genetics KW - Colonies KW - Aquatic insects KW - Feeding KW - Adaptations KW - Sympatric populations KW - Vectors KW - Pest control KW - Plasmodium KW - Infectivity KW - Mexico KW - Population structure KW - Anopheles pseudopunctipennis KW - G 07790:Other Microorganisms KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08522:Protective measures and control KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20909832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biology+and+Evolution&rft.atitle=Local+Adaptation+and+Vector-Mediated+Population+Structure+in+Plasmodium+vivax+Malaria&rft.au=Joy%2C+Deirdre+A%3BGonzalez-Ceron%2C+Lilia%3BCarlton%2C+Jane+M%3BGueye%2C+Amy%3BFay%2C+Michael%3BMcCutchan%2C+Thomas+F%3BSu%2C+Xin-zhuan&rft.aulast=Joy&rft.aufirst=Deirdre&rft.date=2008-06-01&rft.volume=25&rft.issue=6&rft.spage=1245&rft.isbn=&rft.btitle=&rft.title=Molecular+Biology+and+Evolution&rft.issn=07374038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Adaptations; Malaria; Pest control; Hosts; Aquatic insects; Public health; Disease transmission; Feeding; Molecular modelling; Sympatric populations; Vectors; CSP gene; circumsporozoite protein; Population genetics; Infectivity; Colonies; Population structure; Plasmodium; Plasmodium vivax; Anopheles pseudopunctipennis; Anopheles albimanus; Mexico ER - TY - JOUR T1 - Origins of Human Malaria: Rare Genomic Changes and Full Mitochondrial Genomes Confirm the Relationship of Plasmodium falciparum to Other Mammalian Parasites but Complicate the Origins of Plasmodium vivax AN - 20907333; 8202226 AB - Despite substantial work, the phylogeny of malaria parasites remains debated. The matter is complicated by concerns about patterns of evolution in potentially strongly selected genes as well as the extreme AT bias of some Plasmodium genomes. Particularly contentious has been the position of the most virulent human parasite Plasmodium falciparum, whether grouped with avian parasites or within a larger clade of mammalian parasites. Here, we study 3 classes of rare genomic changes, as well as the sequences of mitochondrial ribosomal RNA (rRNA) genes. We report 3 lines of support for a clade of mammalian parasites: 1) we find no instances of spliceosomal intron loss in a hypothetical ancestor of P. falciparum and the avian parasite Plasmodium gallinaceum, suggesting against a close relationship between those species; 2) we find 4 genomic mitochondrial indels supporting a mammalian clade, but none grouping P. falciparum with avian parasites; and 3) slowly evolving mitochondrial rRNA sequences support a mammalian parasite clade with 100% posterior probability. We further report a large deletion in the mitochondrial large subunit rRNA gene, which suggests a subclade including both African and Asian parasites within the clade of closely related primate malarias. This contrasts with previous studies that provided strong support for separate Asian and African clades, and reduces certainty about the historical and geographic origins of Plasmodium vivax. Finally, we find a lack of synapomorphic gene losses, suggesting a low rate of ancestral gene loss in PLASMODIUM: JF - Molecular Biology and Evolution AU - Roy, Scott William AU - Irimia, Manuel AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD. Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain Y1 - 2008/06// PY - 2008 DA - June 2008 SP - 1192 EP - 1198 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk] VL - 25 IS - 6 SN - 0737-4038, 0737-4038 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts KW - Genomes KW - Parasites KW - Human diseases KW - Nucleotide sequence KW - Mitochondria KW - Plasmodium vivax KW - Malaria KW - Public health KW - rRNA KW - Molecular biology KW - Gene deletion KW - Plasmodium gallinaceum KW - genomics KW - Evolutionary genetics KW - Phylogeny KW - Plasmodium falciparum KW - Primates KW - Introns KW - Africa KW - Evolution KW - G 07790:Other Microorganisms KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20907333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biology+and+Evolution&rft.atitle=Origins+of+Human+Malaria%3A+Rare+Genomic+Changes+and+Full+Mitochondrial+Genomes+Confirm+the+Relationship+of+Plasmodium+falciparum+to+Other+Mammalian+Parasites+but+Complicate+the+Origins+of+Plasmodium+vivax&rft.au=Roy%2C+Scott+William%3BIrimia%2C+Manuel&rft.aulast=Roy&rft.aufirst=Scott&rft.date=2008-06-01&rft.volume=25&rft.issue=6&rft.spage=1192&rft.isbn=&rft.btitle=&rft.title=Molecular+Biology+and+Evolution&rft.issn=07374038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Genomes; Phylogeny; Molecular biology; Parasites; Human diseases; Nucleotide sequence; Malaria; Evolution; Public health; rRNA; Gene deletion; Introns; Mitochondria; Evolutionary genetics; genomics; Plasmodium gallinaceum; Plasmodium vivax; Plasmodium falciparum; Primates; Africa ER - TY - JOUR T1 - Modeling Longitudinal Biomarker Data from Multiple Assays that Have Different Known Detection Limits AN - 20901951; 8383074 AB - Summary; Assays to measure biomarkers are commonly subject to large amounts of measurement error and known detection limits. Studies with longitudinal biomarker measurements may use multiple assays in assessing outcome. I propose an approach for jointly modeling repeated measures of multiple assays when these assays are subject to measurement error and known lower detection limits. A commonly used approach is to perform an initial assay with a larger lower detection limit on all repeated samples, followed by only performing a second more expensive assay with a lower minimum level of detection when the initial assay value is below its lower limit of detection. I show how simply replacing the initial assay measurement with the second assay measurement may be a biased approach and investigate the performance of the proposed joint model in this situation. Additionally, I compare the performance of the joint model with an approach that only uses the initial assay measurements in analysis. Further, I consider alternative designs to only performing the second assay when the initial assay measurement is below its lower detection limit. Specifically, I show that one only needs to perform the second assay on a fraction of assays that are above the lower detection limit on the first assay to substantially increase the efficiency. Further, I show the efficiency advantages of performing the second assay at random without regard to the initial assay measurement over a design in which the second assay is only performed when the initial assay is below its lower limit of detection. The methodology is illustrated with a recent study examining the use of a vaccine in treating macaques with simian immunodeficiency virus. JF - Biometrics AU - Albert, Paul S AD - Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, U.S.A. Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 527 EP - 537 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 64 IS - 2 SN - 0006-341X, 0006-341X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Below the level of detection KW - Linear mixed models KW - Measurement error KW - Random effects models KW - Repeated measures data KW - Simian immunodeficiency virus KW - Data processing KW - Macaca KW - Biometrics KW - Vaccines KW - biomarkers KW - Models KW - V 22300:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20901951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Modeling+Longitudinal+Biomarker+Data+from+Multiple+Assays+that+Have+Different+Known+Detection+Limits&rft.au=Albert%2C+Paul+S&rft.aulast=Albert&rft.aufirst=Paul&rft.date=2008-06-01&rft.volume=64&rft.issue=2&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/10.1111%2Fj.1541-0420.2007.00886.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Vaccines; Biometrics; biomarkers; Models; Macaca; Simian immunodeficiency virus DO - http://dx.doi.org/10.1111/j.1541-0420.2007.00886.x ER - TY - JOUR T1 - Intracranial self-administration of MDMA into the ventral striatum of the rat: differential roles of the nucleus accumbens shell, core, and olfactory tubercle AN - 20890100; 8308959 AB - Rationale: Behavioral and anatomical data suggest that the ventral striatum, consisting of the nucleus accumbens and olfactory tubercle, is functionally heterogeneous. Cocaine and d-amphetamine appear to be more rewarding when administered into the medial olfactory tubercle or medial accumbens shell than into their lateral counterparts, including the accumbens core. Objectives: We sought to determine whether rats self-administer the popular recreational drug ( plus or minus )-3,4-methylenedioxymethamphetamine (MDMA) into ventrostriatal subregions and whether the medial olfactory tubercle and medial accumbens shell mediate MDMA's positive reinforcing effects more effectively than their lateral counterparts. Results: Rats receiving 30 mM MDMA into the medial olfactory tubercle, medial accumbens shell, or accumbens core, but not the lateral tubercle or lateral shell, showed higher self-administration rates than rats receiving vehicle. The medial shell supported more vigorous self-administration of MDMA at higher concentrations than the core or medial olfactory tubercle. In addition, intra-medial shell MDMA self-administration was disrupted by co-administration of the D1 or D2 receptor antagonists SCH 23390 (1-3 mM) or raclopride (3-10 mM). Conclusions: Our data suggest that the ventral striatum is functionally heterogeneous. The medial accumbens shell appears to be more important than other ventrostriatal subregions in mediating the positive reinforcing effects of MDMA via both D1- and D2-type receptors. Together with previous data, our data also suggest that unidentified actions of MDMA interfere with the positive reinforcing effects of dopamine in the medial olfactory tubercle. JF - Psychopharmacology AU - Shin, Rick AU - Qin, Mei AU - Liu, Zhong-Hua AU - Ikemoto, Satoshi AD - US Department of Health and Human Services, 251 Bayview Boulevard, Room 08A711, Baltimore, MD, 21224, USA, sikemoto@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 261 EP - 270 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 198 IS - 2 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Animal Behavior Abstracts KW - Dopamine D2 receptors KW - Nucleus accumbens KW - raclopride KW - Dopamine D1 receptors KW - Drug abuse KW - MDMA KW - Olfactory bulb KW - Antagonists KW - Neostriatum KW - Amphetamine KW - Cocaine KW - Drug self-administration KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25110:Biochemical & Neurophysiological Correlates, Lesions and Stimuli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20890100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Intracranial+self-administration+of+MDMA+into+the+ventral+striatum+of+the+rat%3A+differential+roles+of+the+nucleus+accumbens+shell%2C+core%2C+and+olfactory+tubercle&rft.au=Shin%2C+Rick%3BQin%2C+Mei%3BLiu%2C+Zhong-Hua%3BIkemoto%2C+Satoshi&rft.aulast=Shin&rft.aufirst=Rick&rft.date=2008-06-01&rft.volume=198&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-008-1131-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Nucleus accumbens; raclopride; Neostriatum; Dopamine D1 receptors; Amphetamine; Drug abuse; Cocaine; MDMA; Antagonists; Olfactory bulb; Drug self-administration DO - http://dx.doi.org/10.1007/s00213-008-1131-x ER - TY - JOUR T1 - Perinatal factors and the risk of testicular germ cell tumors AN - 20873415; 8367636 AB - Testicular germ cell tumors (TGCT) are the most common cancer among young men in the United States and Western Europe. Prior evidence suggests that TGCT may arise in perinatal life, although few risk factors have yet been identified. To study the etiology of TGCT, the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study enrolled participants and their mothers between 2002 and 2005. Five hundred twenty-seven mothers of cases and 561 mothers of controls provided information on perinatal variables. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95%CI) associated with the candidate risk factors. Analyses were conducted for all TGCT together and for each histologic subgroup (seminoma and nonseminoma) separately. Young maternal age (<20 vs. 20-29 years, OR = 1.51, 95%CI: 1.09-2.10), young paternal age (<25 vs. 25-29 years, OR = 1.45, 95%CI: 1.08-1.94), maternal parity (3 vs. 1, OR = 0.63, 95%CI: 0.44-0.90) and breech birth (OR = 1.92, 95%CI: 1.03-3.56) were associated with risk of TGCT. For seminoma, young maternal age (<20 vs. 20-29 years, OR = 1.67, 95%CI: 1.10-2.54), young paternal age (<25 vs. 25-29 years, OR = 1.53, 95%CI: 1.03-2.27), maternal parity (3 vs. 1, OR = 0.58, 95%CI: 0.35-0.96) and low birth weight (<2,500 g vs. 2,500-4,000 g, OR = 1.82, 95%CI: 1.00-3.30) were risk factors. Nonseminoma was associated with breech birth (OR = 2.44, 95%CI: 1.25-4.78) and Cesarean section (OR = 2.10, 95%CI: 1.25-3.54). These results support the hypothesis that TGCT may originate in very early life. JF - International Journal of Cancer AU - Cook, Michael B AU - Graubard, Barry I AU - Rubertone, Mark V AU - Erickson, Ralph L AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, cookmich@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 2600 EP - 2606 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 11 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - USA KW - Age KW - parity KW - Etiology KW - low-birth-weight KW - Europe KW - tumors KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20873415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Perinatal+factors+and+the+risk+of+testicular+germ+cell+tumors&rft.au=Cook%2C+Michael+B%3BGraubard%2C+Barry+I%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L%3BMcGlynn%2C+Katherine+A&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2008-06-01&rft.volume=122&rft.issue=11&rft.spage=2600&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23424 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Etiology; parity; Age; low-birth-weight; tumors; Cancer; USA; Europe DO - http://dx.doi.org/10.1002/ijc.23424 ER - TY - JOUR T1 - Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States AN - 20870237; 8367634 AB - Squamous cell carcinoma of the conjunctiva (SCCC) has been associated with HIV infection in equatorial Africa, but the evidence for association with HIV in developed countries, where SCCC is rarer, is controversial. We investigated the risk for SCCC and other eye cancers in the updated U.S. HIV/AIDS Cancer Match Registry Study. We calculated standardized incidence ratios (SIRs) to estimate excess risk for SCCC, primary ocular lymphoma, ocular Kaposi sarcoma (KS) and other eye tumors among 49,048 adults (aged > 15 years or older) with HIV/AIDS diagnosed from 1980 to 2004. We calculated relative proportions (per 105) to gain insight into risk factors. We identified 73 eye cancers (15 SCCC, 35 primary ocular lymphoma, 17 ocular KS and 6 other). Overall SIRs were elevated for SCCC (SIR, 12.2, 95% CI 6.8-20.2), primary ocular lymphoma (21.7, 95% CI 15.1-30.2) and ocular KS (109, 95% CI 63.5-175). Risk for SCCC was elevated regardless of HIV acquisition category, CD4 lymphocyte count and time relative to AIDS-onset. Relative proportions of SCCC risk were highest with age 50 (8/105), Hispanic ethnicity (7/105) and residence in regions with high-solar ultraviolet radiation (10/105). We show significantly increased incidence of SCCC among persons with HIV/AIDS in the U.S. The associations with age and geography are in accord with etiological role for ultraviolet radiation in SCCC. JF - International Journal of Cancer AU - Guech-Ongey, Mercy AU - Engels, Eric A AU - Goedert, James J AU - Biggar, Robert J AU - Mbulaiteye, Sam M AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, guechome@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 2590 EP - 2593 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 11 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Virology & AIDS Abstracts KW - Age KW - Acquired immune deficiency syndrome KW - Eye KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - Conjunctiva KW - tumors KW - Lymphocytes KW - Infection KW - CD4 antigen KW - U.V. radiation KW - Risk factors KW - Ultraviolet radiation KW - infection KW - Geography KW - Lymphoma KW - Ethnic groups KW - Cell number KW - squamous cell carcinoma KW - Tumors KW - Cancer KW - USA KW - Human immunodeficiency virus KW - Sarcoma KW - Africa KW - lymphoma KW - developed countries KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20870237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Elevated+risk+for+squamous+cell+carcinoma+of+the+conjunctiva+among+adults+with+AIDS+in+the+United+States&rft.au=Guech-Ongey%2C+Mercy%3BEngels%2C+Eric+A%3BGoedert%2C+James+J%3BBiggar%2C+Robert+J%3BMbulaiteye%2C+Sam+M&rft.aulast=Guech-Ongey&rft.aufirst=Mercy&rft.date=2008-06-01&rft.volume=122&rft.issue=11&rft.spage=2590&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23384 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Age; Eye; Cell number; Conjunctiva; squamous cell carcinoma; Tumors; Infection; CD4 antigen; U.V. radiation; Risk factors; Sarcoma; Geography; Lymphoma; Ethnic groups; Ultraviolet radiation; infection; tumors; Lymphocytes; lymphoma; Cancer; developed countries; Human immunodeficiency virus; USA; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir; Africa DO - http://dx.doi.org/10.1002/ijc.23384 ER - TY - JOUR T1 - Effects of Action Observation on Physical Training After Stroke AN - 20851883; 8305173 AB - BACKGROUND: and Purpose- In healthy humans, observation of another individual performing a motor training task (action observation [AO]) facilitates, in the observer, the effects of physical training (PT) on motor memory formation. It is not known whether this facilitatory process, of potential value for neurorehabilitation, occurs after stroke. METHODS: Eight chronic stroke patients completed this crossover-randomized investigation. A transcranial magnetic stimulation protocol that tests formation of motor memories was used to determine the effects of PT alone and in combination with AO in 2 different forms: congruent (PT+AO sub(congruent)) and incongruent (PT+AO sub(incongruent)) to the practiced task. RESULTS: The magnitude of motor memory formation was larger with PT+AO sub(congruent) than with PT alone or PT+AO sub(incongruent). This effect was associated with a differential corticomotor excitability change in the muscles acting as agonist and antagonist of the trained/observed movements. CONCLUSIONS: These results indicate that congruent AO in association with physical training can enhance the effects of motor training after stroke. JF - Stroke AU - Celnik, Pablo AU - Webster, Brian AU - Glasser, Davis M AU - Cohen, Leonardo G AD - Human Cortical Physiology Section and Stroke Neurorehabilitation Clinic (P.C., B.W., D.M.G., L.G.C.), NINDS, NIH, Bethesda, Md Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 1814 EP - 1820 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 USA, [URL:http://www.lww.com/] VL - 39 IS - 6 SN - 0039-2499, 0039-2499 KW - Physical Education Index KW - Stroke KW - Muscles KW - Motor performance tests KW - Stimuli KW - Patients KW - Health KW - Observation KW - Movement KW - Motor recall KW - PE 050:Coaching & Training UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20851883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Effects+of+Action+Observation+on+Physical+Training+After+Stroke&rft.au=Celnik%2C+Pablo%3BWebster%2C+Brian%3BGlasser%2C+Davis+M%3BCohen%2C+Leonardo+G&rft.aulast=Celnik&rft.aufirst=Pablo&rft.date=2008-06-01&rft.volume=39&rft.issue=6&rft.spage=1814&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=00392499&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stroke; Observation; Motor recall; Muscles; Stimuli; Motor performance tests; Health; Movement; Patients ER - TY - JOUR T1 - Endosome fusion induced by diphtheria toxin translocation domain AN - 20849976; 8304522 AB - Endosomal cargo travels through a dynamic vesicle network en route to degradation by lysosomes or recycling through the Golgi apparatus back to the cell surface. Rab5 is a key determinant of the early endosomes by organizing effector proteins in specific subdomains and mediating early endosome fusion. We find that early endosome morphogenesis and maturation is disrupted by diphtheria toxin (DT). Rab5 bound endosomes increase in size and in Rab5 content due to luminal toxin exposure, whereas Rab7 positive endosomes are not detectably altered. These changes appear to be caused by an activity of the toxin entry domain (T domain) as mutations inactivating either the receptor binding (CRM107) or ADP-ribosyl transferase (CRM197) activities do not inhibit the effect of DT on endosome morphogenesis. In contrast, mutations in the T domain or diminishing the endosomal pH gradient, which prevents T domain membrane insertion, inhibit these endosome changes. The change in size appears to be due to changing the early endosome fission-fusion equilibrium. The Rab5 membrane exchange rate, assessed with photoactivatable GFP-Rab5, decreases in the presence of DT. These changes to endosomes may reflect activities of the T domain that mediate toxin entry to the cytosol. The nontoxic mutant DT, CRM197, yields a new tool to manipulate endosome dynamics in living cells. JF - Proceedings of the National Academy of Sciences, USA AU - Antignani, Antonella AU - Youle, Richard J AD - Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive MSC 3704, Bethesda, MD 20892 Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 8020 EP - 8025 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 23 SN - 0027-8424, 0027-8424 KW - Toxicology Abstracts; Sustainability Science Abstracts; Genetics Abstracts KW - Travel KW - Golgi apparatus KW - Cell surface KW - Morphogenesis KW - Recycling KW - Waste management KW - Mutants KW - currency exchange rate KW - Vesicles KW - Translocation KW - pH effects KW - pH KW - Membranes KW - Diphtheria toxin KW - Toxins KW - endosomes KW - Cytosol KW - Proteins KW - translocation KW - Mutation KW - Lysosomes KW - X 24370:Natural Toxins KW - M3 1010:Issues in Sustainable Development KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20849976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Endosome+fusion+induced+by+diphtheria+toxin+translocation+domain&rft.au=Antignani%2C+Antonella%3BYoule%2C+Richard+J&rft.aulast=Antignani&rft.aufirst=Antonella&rft.date=2008-06-01&rft.volume=105&rft.issue=23&rft.spage=8020&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; Golgi apparatus; Morphogenesis; Recycling; Toxins; Diphtheria toxin; endosomes; Cytosol; Vesicles; Mutation; pH effects; Translocation; Lysosomes; Travel; Membranes; Proteins; currency exchange rate; translocation; pH; Mutants; Waste management ER - TY - JOUR T1 - Affibody Molecules for In vivo Characterization of HER2-Positive Tumors by Near-Infrared Imaging AN - 20784820; 8301354 AB - PURPOSE: HER2 overexpression has been associated with a poor prognosis and resistance to therapy in breast cancer patients. We are developing molecular probes for in vivo quantitative imaging of HER2 receptors using near-infrared (NIR) optical imaging. The goal is to provide probes that will minimally interfere with the studied system, that is, whose binding does not interfere with the binding of the therapeutic agents and whose effect on the target cells is minimal. Experimental Design: We used three different types of HER2-specific Affibody molecules [monomer Z sub(HER2:342), dimer (Z sub(HER2:477)) sub(2), and albumin-binding domain-fused-(Z sub(HER2:342)) sub(2)] as targeting agents and labeled them with Alexa Fluor dyes. Trastuzumab was also conjugated, using commercially available kits, as a standard control. The resulting conjugates were characterized in vitro by toxicity assays, Biacore affinity measurements, flow cytometry, and confocal microscopy. Semiquantitative in vivo NIR optical imaging studies were carried out using mice with s.c. xenografts of HER2-positive tumors. RESULTS: The HER2-specific Affibody molecules were not toxic to HER2-overexpressing cells and their binding to HER2 did interfere with neither binding nor effectives of trastuzumab. The binding affinities and specificities of the Affibody-Alexa Fluor fluorescent conjugates to HER2 were unchanged or minimally affected by the modifications. Pharmacokinetics and biodistribution studies showed the albumin-binding domain-fused-(Z sub(HER2:342)) sub(2)-Alexa Fluor 750 conjugate to be an optimal probe for optical imaging of HER2 in vivo. CONCLUSION: Our results suggest that Affibody-Alexa Fluor conjugates may be used as a specific NIR probe for the noninvasive semiquantitative imaging of HER2 expression in vivo. JF - Clinical Cancer Research AU - Lee, Sang Bong AU - Hassan, Moinuddin AU - Fisher, Robert AU - Chertov, Oleg AU - Chernomordik, Victor AU - Kramer-Marek, Gabriela AU - Gandjbakhche, Amir AU - Capala, Jacek AD - Authors' Affiliations: Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute and Section on Biomedical Stochastic Physics, Laboratory of Integrative and Medical Biophysics, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 3840 EP - 3849 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 14 IS - 12 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - ErbB-2 protein KW - Probes KW - Prognosis KW - Toxicity KW - Tumors KW - trastuzumab KW - imaging KW - Pharmacokinetics KW - Monomers KW - Flow cytometry KW - Dyes KW - Confocal microscopy KW - Breast cancer KW - Xenografts KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20784820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Affibody+Molecules+for+In+vivo+Characterization+of+HER2-Positive+Tumors+by+Near-Infrared+Imaging&rft.au=Lee%2C+Sang+Bong%3BHassan%2C+Moinuddin%3BFisher%2C+Robert%3BChertov%2C+Oleg%3BChernomordik%2C+Victor%3BKramer-Marek%2C+Gabriela%3BGandjbakhche%2C+Amir%3BCapala%2C+Jacek&rft.aulast=Lee&rft.aufirst=Sang&rft.date=2008-06-01&rft.volume=14&rft.issue=12&rft.spage=3840&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - ErbB-2 protein; Prognosis; Probes; Tumors; Toxicity; trastuzumab; imaging; Pharmacokinetics; Flow cytometry; Monomers; Dyes; Confocal microscopy; Breast cancer; Xenografts ER - TY - JOUR T1 - A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker AN - 20780969; 8289974 AB - Measurement of cell membrane integrity has been widely used to assess chemical cytotoxity. Several assays are available for determining cell membrane integrity including differential labeling techniques using neutral red and trypan blue dyes or fluorescent compounds such as propidium iodide. Other common methods for assessing cytotoxicity are enzymatic ''release'' assays which measure the extra-cellular activities of lactate dehydrogenase (LDH), adenylate kinase (AK), or glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in culture medium. However, all these assays suffer from several practical limitations, including multiple reagent additions, scalability, low sensitivity, poor linearity, or requisite washes and medium exchanges. We have developed a new cytotoxicity assay which measures the activity of released intracellular proteases as a result of cell membrane impairment. It allows for a homogenous, one-step addition assay with a luminescent readout. We have optimized and miniaturized this assay into a 1536-well format, and validated it by screening a library of known compounds from the National Toxicology Program (NTP) using HEK 293 and human renal mesangial cells by quantitative high-throughput screening (qHTS). Several known and novel membrane disrupters were identified from the library, which indicates that the assay is robust and suitable for large scale library screening. This cytotoxicity assay, combined with the qHTS platform, allowed us to quickly and efficiently evaluate compound toxicities related to cell membrane integrity. JF - Toxicology In Vitro AU - Cho, M H AU - Niles, A AU - Huang, R AU - Inglese, J AU - Austin, C P AU - Riss, T AU - Xia, M AD - National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370, USA, mxia@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1099 EP - 1106 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 22 IS - 4 SN - 0887-2333, 0887-2333 KW - Toxicology Abstracts KW - Proteolysis KW - propidium iodide KW - Adenylate kinase KW - Cell culture KW - Toxicity KW - biomarkers KW - L-Lactate dehydrogenase KW - Glyceraldehyde-3-phosphate dehydrogenase KW - Cytotoxicity KW - Cell membranes KW - Dyes KW - Kidney KW - high-throughput screening KW - Proteinase KW - Mesangial cells KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20780969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=A+bioluminescent+cytotoxicity+assay+for+assessment+of+membrane+integrity+using+a+proteolytic+biomarker&rft.au=Cho%2C+M+H%3BNiles%2C+A%3BHuang%2C+R%3BInglese%2C+J%3BAustin%2C+C+P%3BRiss%2C+T%3BXia%2C+M&rft.aulast=Cho&rft.aufirst=M&rft.date=2008-06-01&rft.volume=22&rft.issue=4&rft.spage=1099&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2008.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Proteolysis; propidium iodide; Adenylate kinase; Cell culture; Toxicity; biomarkers; L-Lactate dehydrogenase; Cytotoxicity; Glyceraldehyde-3-phosphate dehydrogenase; Cell membranes; Dyes; Kidney; Proteinase; high-throughput screening; Mesangial cells DO - http://dx.doi.org/10.1016/j.tiv.2008.02.013 ER - TY - JOUR T1 - Insulin-like Growth Factor 1, Insulin-like Growth Factor-Binding Protein 3, and Testicular Germ-Cell Tumor Risk AN - 20733737; 8300034 AB - Studies have consistently shown that taller men are at increased risk of testicular germ-cell tumors. Thus, it is plausible that factors associated with height may also influence risk of these tumors. The authors examined associations between testicular germ-cell tumor risk and circulating concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) among 517 cases and 790 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) Study (2002-2005). Odds ratios and 95% confidence intervals were estimated using logistic regression models, adjusting for age, race/ethnicity, height, and body mass index. All tests of significance were two-sided. Overall, there were no associations between IGF-1 or IGFBP-3 concentrations and risk of testicular germ-cell tumors (p > 0.05). However, when cases were separated by histologic type, there was a suggestion of a reduction in seminoma risk associated with the highest concentrations of IGF-1 as compared with the lowest concentrations (odds ratio = 0.66, 95% confidence interval: 0.40, 1.09). Although there were no overall associations with insulin-like growth factor, contrary to expectation, there was a suggestion that IGF-1 concentrations may be inversely associated with risk of seminoma. JF - American Journal of Epidemiology AU - Chia, Victoria M AU - Quraishi, Sabah M AU - Graubard, Barry I AU - Rubertone, Mark V AU - Erickson, Ralph L AU - Stanczyk, Frank Z AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1438 EP - 1445 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 12 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Growth KW - Age KW - body mass KW - Proteins KW - tumors KW - growth factors KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20733737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Insulin-like+Growth+Factor+1%2C+Insulin-like+Growth+Factor-Binding+Protein+3%2C+and+Testicular+Germ-Cell+Tumor+Risk&rft.au=Chia%2C+Victoria+M%3BQuraishi%2C+Sabah+M%3BGraubard%2C+Barry+I%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L%3BStanczyk%2C+Frank+Z%3BMcGlynn%2C+Katherine+A&rft.aulast=Chia&rft.aufirst=Victoria&rft.date=2008-06-01&rft.volume=167&rft.issue=12&rft.spage=1438&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Growth; body mass; Proteins; tumors; growth factors; Ethnic groups ER - TY - JOUR T1 - Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study AN - 20730644; 8310657 AB - Objective: Fruit and vegetable intake may protect against gastric cancer incidence. Results from case-control studies have indicated an inverse association, but results from cohort studies are inconsistent. Methods: We prospectively investigated the association in 490,802 participants of the NIH-AARP Diet and Health Study using Cox proportional hazards models adjusted for gastric cancer risk factors. We present hazard ratios (HR) and 95% confidence intervals (CI) per increase of one daily serving per 1,000 calories. Results: During 2,193,751 person years, 394 participants were diagnosed with incident gastric cancer. We observed no significant associations between total fruit and vegetable intake (1.01, 0.95-1.08), fruit intake (1.04, 0.95-1.14), or vegetable intake (0.98, 0.88-1.08) and gastric cancer risk. Results did not vary by sex or anatomic subsite (cardia versus non-cardia). All 13 botanical subgroups examined had no significant associations with either anatomic sub-site. Conclusion: We did not observe significant associations between overall fruit and vegetable intake and gastric cancer risk in this large prospective cohort study. JF - Cancer Causes & Control AU - Freedman, Neal D AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Leitzmann, Michael F AU - Schatzkin, Arthur AU - Abnet, Christian C AD - NIH, DHHS, 6120 Executive Blvd, EPS/320, MSC 7232, Rockville, MD, 20852, USA, freedmanne@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 459 EP - 467 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 19 IS - 5 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Diets KW - USA KW - fruits KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20730644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Fruit+and+vegetable+intake+and+gastric+cancer+risk+in+a+large+United+States+prospective+cohort+study&rft.au=Freedman%2C+Neal+D%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2008-06-01&rft.volume=19&rft.issue=5&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-9107-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; fruits; Cancer; USA DO - http://dx.doi.org/10.1007/s10552-007-9107-4 ER - TY - JOUR T1 - Mammography Facility Characteristics Associated With Interpretive Accuracy of Screening Mammography AN - 20726483; 8303372 AB - BACKGROUND: Although interpretive performance varies substantially among radiologists, such variation has not been examined among mammography facilities. Understanding sources of facility variation could become a foundation for improving interpretive performance. METHODS: In this cross-sectional study conducted between 1996 and 2002, we surveyed 53 facilities to evaluate associations between facility structure, interpretive process characteristics, and interpretive performance of screening mammography (ie, sensitivity, specificity, positive predictive value [PPV1], and the likelihood of cancer among women who were referred for biopsy [PPV2]). Measures of interpretive performance were ascertained prospectively from mammography interpretations and cancer data collected by the Breast Cancer Surveillance Consortium. Logistic regression and receiver operating characteristic (ROC) curve analyses estimated the association between facility characteristics and mammography interpretive performance or accuracy (area under the ROC curve [AUC]). All P values were two-sided. RESULTS: Of the 53 eligible facilities, data on 44 could be analyzed. These 44 facilities accounted for 484 463 screening mammograms performed on 237 669 women, of whom 2686 were diagnosed with breast cancer during follow-up. Among the 44 facilities, mean sensitivity was 79.6% (95% confidence interval [CI] = 74.3% to 84.9%), mean specificity was 90.2% (95% CI = 88.3% to 92.0%), mean PPV1 was 4.1% (95% CI = 3.5% to 4.7%), and mean PPV2 was 38.8% (95% CI = 32.6% to 45.0%). The facilities varied statistically significantly in specificity (P < .001), PPV1 (P < .001), and PPV2 (P = .002) but not in sensitivity (P = .99). AUC was higher among facilities that offered screening mammograms alone vs those that offered screening and diagnostic mammograms (0.943 vs 0.911, P = .006), had a breast imaging specialist interpreting mammograms vs not (0.932 vs 0.905, P = .004), did not perform double reading vs independent double reading vs consensus double reading (0.925 vs 0.915 vs 0.887, P = .034), or conducted audit reviews two or more times per year vs annually vs at an unknown frequency (0.929 vs 0.904 vs 0.900, P = .018). CONCLUSION: Mammography interpretive performance varies statistically significantly by facility. JF - Journal of the National Cancer Institute AU - Taplin, Stephen AU - Abraham, Linn AU - Barlow, William E AU - Fenton, Joshua J AU - Berns, Eric A AU - Carney, Patricia A AU - Cutter, Gary R AU - Sickles, Edward A AU - Carl, D'Orsi AU - Elmore, Joann G AD - Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD (ST) Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 876 EP - 887 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 100 IS - 12 SN - 0027-8874, 0027-8874 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Mammography+Facility+Characteristics+Associated+With+Interpretive+Accuracy+of+Screening+Mammography&rft.au=Taplin%2C+Stephen%3BAbraham%2C+Linn%3BBarlow%2C+William+E%3BFenton%2C+Joshua+J%3BBerns%2C+Eric+A%3BCarney%2C+Patricia+A%3BCutter%2C+Gary+R%3BSickles%2C+Edward+A%3BCarl%2C+D%27Orsi%3BElmore%2C+Joann+G&rft.aulast=Taplin&rft.aufirst=Stephen&rft.date=2008-06-01&rft.volume=100&rft.issue=12&rft.spage=876&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Interlaboratory Comparison of Results of an Anthrax Lethal Toxin Neutralization Assay for Assessment of Functional Antibodies in Multiple Species AN - 20724535; 8301043 AB - The anthrax lethal toxin neutralization assay (TNA) will likely be used to correlate the protection offered by new anthrax vaccines in animal models to the immunogenicity that will be provided in humans. TNA data are being generated in several different laboratories to measure the immune responses in rabbits, nonhuman primates, and humans. In order to compare data among species and laboratories, a collaborative study was conducted in which 108 samples from the three species were analyzed in seven independent laboratories. Six of the seven laboratories had participated in an interlaboratory technology transfer of the TNA. Analysis of the titration curves generated by samples from each species indicated that the behaviors of the samples from all species were similar; the upper and lower asymptotes and the slopes of the curves were less than 30% divergent from those for human reference material. Dilutional linearity was consistent among samples from each species, with spike to effective dilution at 50% inhibition (ED sub(50)) slopes of less than 1.2 for all species. Agreement among the laboratories with consensus values was within 10% of the ED sub(50)s for all samples and within 7.5% of the quotients of the test sample ED sub(50) and the reference standard ED sub(50) (NF sub(50)s) for all samples. The relative standard deviations obtained when data from all laboratories and for all species were combined were 45% for the ED sub(50)s and 35% for the NF sub(50)s. These precision data suggest that the NF sub(50) readout may normalize the values generated by different laboratories. This study demonstrates that the TNA is a panspecies assay that can be performed in several different laboratories with a high degree of quantitative agreement and precision. JF - Clinical and Vaccine Immunology AU - Omland, Kristian S AU - Brys, April AU - Lansky, David AU - Clement, Kristin AU - Lynn, Freyja AD - Precision Bioassay, Burlington, Vermont. Battelle Eastern Science and Technology Center, Aberdeen, Maryland. Battelle Biomedical Research Center, West Jefferson, Ohio. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 946 EP - 953 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 15 IS - 6 SN - 1556-6811, 1556-6811 KW - Toxicology Abstracts; Immunology Abstracts KW - Anthrax lethal toxin KW - Antibodies KW - Standard deviation KW - Data processing KW - Immunogenicity KW - Titration KW - Animal models KW - Anthrax KW - Vaccines KW - Immune response KW - Primates KW - F 06905:Vaccines KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Interlaboratory+Comparison+of+Results+of+an+Anthrax+Lethal+Toxin+Neutralization+Assay+for+Assessment+of+Functional+Antibodies+in+Multiple+Species&rft.au=Omland%2C+Kristian+S%3BBrys%2C+April%3BLansky%2C+David%3BClement%2C+Kristin%3BLynn%2C+Freyja&rft.aulast=Omland&rft.aufirst=Kristian&rft.date=2008-06-01&rft.volume=15&rft.issue=6&rft.spage=946&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Antibodies; Data processing; Standard deviation; Immunogenicity; Titration; Animal models; Anthrax; Immune response; Vaccines; Primates ER - TY - JOUR T1 - Transferrin Receptor Expression in Iron Oxide-labeled Mesenchymal Stem Cells AN - 20678358; 8203639 JF - Radiology AU - Pawelczyk, Edyta AU - Frank, Joseph A AD - Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, pawelczyke@cc.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 913 EP - 914 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 247 IS - 3 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Transferrin receptors KW - Mesenchyme KW - Iron KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20678358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Transferrin+Receptor+Expression+in+Iron+Oxide-labeled+Mesenchymal+Stem+Cells&rft.au=Pawelczyk%2C+Edyta%3BFrank%2C+Joseph+A&rft.aulast=Pawelczyk&rft.aufirst=Edyta&rft.date=2008-06-01&rft.volume=247&rft.issue=3&rft.spage=913&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Stem cells; Transferrin receptors; Mesenchyme; Iron ER - TY - JOUR T1 - Modeling Neonatal Thimerosal Exposure in Mice AN - 20677092; 8204111 JF - Toxicological Sciences AU - Berman, Robert F AU - Pessah, Issac N AU - Mouton, Peter R AU - Mav, Deepak AU - Harry, GJean AD - Department of Neurological Surgery and the Center for Children's Environmental Health, University of California Davis, California 95616. Center for Children's Environmental Health and Department of Molecular Biosciences, University of California Davis, California 95616. Stereology Resource Center, 104 Ringneck Court, Chester, Maryland 21619. Constella Group, LLC, Durham, North Carolina 27713. Neurotoxicology Group, Laboratory of Neurobiology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 416 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - thimerosal KW - Neonates KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20677092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=New+York+Times&rft.atitle=Study+Finds+29-Week+Fetuses+Probably+Feel+No+Pain+and+Need+No+Abortion+Anesthesia&rft.au=Grady%2C+Denise&rft.aulast=Grady&rft.aufirst=Denise&rft.date=2005-08-24&rft.volume=&rft.issue=&rft.spage=A.10&rft.isbn=&rft.btitle=&rft.title=New+York+Times&rft.issn=03624331&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - thimerosal; Neonates ER - TY - JOUR T1 - Vaccinia Virus A56/K2 Fusion Regulatory Protein Interacts with the A16 and G9 Subunits of the Entry Fusion Complex AN - 20675602; 8201898 AB - Deletion of the A56R or K2L gene of vaccinia virus (VACV) results in the spontaneous fusion of infected cells to form large multinucleated syncytia. A56 and K2 polypeptides bind to one another (A56/K2) and together are required for interaction with the VACV entry fusion complex (EFC); this association has been proposed to prevent the fusion of infected cells. At least eight viral polypeptides comprise the EFC, but no information has been available regarding their interactions either with each other or with A56/K2. Utilizing a panel of recombinant VACVs designed to repress expression of individual EFC subunits, we demonstrated that A56/K2 interacted with two polypeptides: A16 and G9. Both A16 and G9 were required for the efficient binding of each to A56/K2, suggesting that the two polypeptides interact with each other within the EFC. Such an interaction was established by the copurification of A16 and G9 from infected cells under conditions in which a stable EFC complex failed to assemble and from detergent-treated lysates of uninfected cells that coexpressed A16 and G9. A recombinant VACV that expressed G9 modified with an N-terminal epitope tag induced the formation of syncytia, suggesting partial interference with the functional interaction of A56/K2 with the EFC during infection. These data suggest that A16 and G9 are physically associated within the EFC and that their interaction with A56/K2 suppresses spontaneous syncytium formation and possibly "fuse-back" superinfection of cells. JF - Journal of Virology AU - Wagenaar, Timothy R AU - Ojeda, Suany AU - Moss, Bernard AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0310. Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742 Y1 - 2008/06/01/ PY - 2008 DA - 2008 Jun 01 SP - 5153 EP - 5160 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 82 IS - 11 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Gene deletion KW - Vaccinia virus KW - regulatory proteins KW - Syncytia KW - Fusion protein KW - Superinfection KW - Epitopes KW - W 30925:Genetic Engineering KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20675602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Vaccinia+Virus+A56%2FK2+Fusion+Regulatory+Protein+Interacts+with+the+A16+and+G9+Subunits+of+the+Entry+Fusion+Complex&rft.au=Wagenaar%2C+Timothy+R%3BOjeda%2C+Suany%3BMoss%2C+Bernard&rft.aulast=Wagenaar&rft.aufirst=Timothy&rft.date=2008-06-01&rft.volume=82&rft.issue=11&rft.spage=5153&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene deletion; regulatory proteins; Syncytia; Fusion protein; Superinfection; Epitopes; Vaccinia virus ER - TY - JOUR T1 - Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy AN - 20672466; 8230732 AB - Single-molecule force spectroscopy has emerged as a powerful tool to investigate the forces and motions associated with biological molecules and enzymatic activity. The most common force spectroscopy techniques are optical tweezers, magnetic tweezers and atomic force microscopy. Here we describe these techniques and illustrate them with examples highlighting current capabilities and limitations. JF - Nature Methods AU - Neuman, Keir C AU - Nagy, Attila AD - Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, 50 South Drive, Bethesda, Maryland 20892, USA., neumankc@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 491 EP - 505 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 5 IS - 6 SN - 1548-7091, 1548-7091 KW - Biotechnology and Bioengineering Abstracts KW - atomic force microscopy KW - Enzymatic activity KW - Spectroscopy KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20672466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Methods&rft.atitle=Single-molecule+force+spectroscopy%3A+optical+tweezers%2C+magnetic+tweezers+and+atomic+force+microscopy&rft.au=Neuman%2C+Keir+C%3BNagy%2C+Attila&rft.aulast=Neuman&rft.aufirst=Keir&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=Nature+Methods&rft.issn=15487091&rft_id=info:doi/10.1038%2Fnmeth.1218 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - atomic force microscopy; Enzymatic activity; Spectroscopy DO - http://dx.doi.org/10.1038/nmeth.1218 ER - TY - JOUR T1 - Occupational physical activities and long-term functional and radiographic outcomes in patients with ankylosing spondylitis AN - 20624661; 9350050 AB - Objective We sought to identify specific occupational activities associated with functional limitations and radiographic damage in patients with longstanding ankylosing spondylitis (AS). Methods We asked patients diagnosed with AS for 20 years to report all past occupations, which we mapped to specific physical activities using the Occupational Information Network, which is the US Department of Labor job classification database. For each occupation reported, we obtained ratings for 13 physical abilities of the worker and 13 aspects of the work environment or work tasks (work context) thought to be most relevant to patients with AS. Averages for each measure, weighted by the number of years in each job, were related to the degree of functional limitation as assessed by the Bath AS Functional Index (BASFI) and to the extent of spinal radiographic damage as assessed by the Bath AS Radiology Index for the spine (BASRI-s). Results Among 397 patients, those with a history of jobs requiring dynamic flexibility (the ability to repeatedly bend, stretch, twist, or reach) had more functional limitations than those whose past jobs required little or no dynamic flexibility (adjusted mean BASFI score 48.3 in the top quartile versus 38.1 in all others). Those whose past jobs required more dynamic flexibility, extent flexibility, and exposure to whole body vibration also had significantly higher BASRI-s scores. Conclusion Bending, twisting, and stretching are the occupational activities associated with greater functional limitations and radiographic damage in patients with longstanding AS. Exposure to whole body vibration was also associated with more radiographic damage. JF - Arthritis & Rheumatism AU - Ward, Michael M AU - Reveille, John D AU - Learch, Thomas J AU - Davis, John C AU - Weisman, Michael H AD - National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, US Department of Health and Human Services, Bethesda, Maryland, wardm1@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 822 EP - 832 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 6 SN - 0004-3591, 0004-3591 KW - Toxicology Abstracts KW - Vibrations KW - Computer programs KW - Databases KW - Workers KW - Ankylosing spondylitis KW - Spine KW - Baths KW - Classification KW - Physical activity KW - Radiology KW - Occupational exposure KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20624661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+%26+Rheumatism&rft.atitle=Occupational+physical+activities+and+long-term+functional+and+radiographic+outcomes+in+patients+with+ankylosing+spondylitis&rft.au=Ward%2C+Michael+M%3BReveille%2C+John+D%3BLearch%2C+Thomas+J%3BDavis%2C+John+C%3BWeisman%2C+Michael+H&rft.aulast=Ward&rft.aufirst=Michael&rft.date=2008-06-01&rft.volume=59&rft.issue=6&rft.spage=822&rft.isbn=&rft.btitle=&rft.title=Arthritis+%26+Rheumatism&rft.issn=00043591&rft_id=info:doi/10.1002%2Fart.23704 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vibrations; Workers; Databases; Computer programs; Spine; Ankylosing spondylitis; Classification; Baths; Physical activity; Radiology; Occupational exposure DO - http://dx.doi.org/10.1002/art.23704 ER - TY - JOUR T1 - Dopamine and reward: The anhedonia hypothesis 30 years on AN - 20143491; 10263374 AB - The anhedonia hypothesis -- that brain dopamine plays a critical role in the subjective pleasure associated with positive rewards -- was intended to draw the attention of psychiatrists to the growing evidence that dopamine plays a critical role in the objective reinforcement and incentive motivation associated with food and water, brain stimulation reward, and psychomotor stimulant and opiate reward. The hypothesis called to attention the apparent paradox that neuroleptics, drugs used to treat a condition involving anhedonia (schizophrenia), attenuated in laboratory animals the positive reinforcement that we normally associate with pleasure. The hypothesis held only brief interest for psychiatrists, who pointed out that the animal studies reflected acute actions of neuroleptics whereas the treatment of schizophrenia appears to result from neuroadaptations to chronic neuroleptic administration, and that it is the positive symptoms of schizophrenia that neuroleptics alleviate, rather than the negative symptoms that include anhedonia. Perhaps for these reasons, the hypothesis has had minimal impact in the psychiatric literature. Despite its limited heuristic value for the understanding of schizophrenia, however, the anhedonia hypothesis has had major impact on biological theories of reinforcement, motivation, and addiction. Brain dopamine plays a very important role in reinforcement of response habits, conditioned preferences, and synaptic plasticity in cellular models of learning and memory. The notion that dopamine plays a dominant role in reinforcement is fundamental to the psychomotor stimulant theory of addiction, to most neuroadaptation theories of addiction, and to current theories of conditioned reinforcement and reward prediction. Properly understood, it is also fundamental to recent theories of incentive motivation. JF - Neurotoxicity Research AU - Wise, Roy A AD - Department of Health and Human Services, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, USA, rwise@intra.nida.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 169 EP - 183 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 14 IS - 2-3 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Opiates KW - Motivation KW - Food KW - Emotional behavior KW - Conditioned reinforcement KW - Brain KW - Laboratory animals KW - Plasticity (synaptic) KW - Psychomotor stimulants KW - Schizophrenia KW - Mental disorders KW - Memory KW - Dopamine KW - Neuroleptics KW - Neurotoxicity KW - Reinforcement KW - Problem solving KW - Addiction KW - Attention KW - Hedonic response KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20143491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=Dopamine+and+reward%3A+The+anhedonia+hypothesis+30+years+on&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2008-06-01&rft.volume=14&rft.issue=2-3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2FBF03033808 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Opiates; Motivation; Food; Conditioned reinforcement; Emotional behavior; Laboratory animals; Brain; Plasticity (synaptic); Psychomotor stimulants; Schizophrenia; Memory; Mental disorders; Dopamine; Neuroleptics; Neurotoxicity; Reinforcement; Problem solving; Addiction; Hedonic response; Attention DO - http://dx.doi.org/10.1007/BF03033808 ER - TY - JOUR T1 - Potent Synergistic Anti-Human Immunodeficiency Virus (HIV) Effects Using Combinations of the CCR5 Inhibitor Aplaviroc with Other Anti-HIV Drugs AN - 20050380; 8299544 AB - Aplaviroc (AVC), an experimental CCR5 inhibitor, potently blocks in vitro the infection of R5-tropic human immunodeficiency virus type 1 (R5-HIV-1) at subnanomolar 50% inhibitory concentrations. Although maraviroc is presently clinically available, further studies are required to determine the role of CCR5 inhibitors in combinations with other drugs. Here we determined anti-HIV-1 activity using combinations of AVC with various anti-HIV-1 agents, including four U.S. Food and Drug Administration-approved drugs, two CCR5 inhibitors (TAK779 and SCH-C) and two CXCR4 inhibitors (AMD3100 and TE14011). Combination effects were defined as synergistic or antagonistic when the activity of drug A combined with B was statistically greater or less, respectively, than the additive effects of drugs A and A combined and drugs B and B combined by using the Combo method, described in this paper, which provides (i) a flexible choice of interaction models and (ii) the use of nonparametric statistical methods. Synergistic effects against R5-HIV-1 sub(Ba-L) and a 50:50 mixture of R5-HIV-1 sub(Ba-L) and X4-HIV-1 sub(ERS104pre) (HIV-1 sub(Ba-L/104pre)) were seen when AVC was combined with zidovudine, nevirapine, indinavir, or enfuvirtide. Mild synergism and additivity were observed when AVC was combined with TAK779 and SCH-C, respectively. We also observed more potent synergism against HIV-1 sub(Ba-L/104pre) when AVC was combined with AMD3100 or TE14011. The data demonstrate a tendency toward greater synergism with AVC plus either of the two CXCR4 inhibitors compared to the synergism obtained with combinations of AVC and other drugs, suggesting that the development of effective CXCR4 inhibitors may be important for increasing the efficacies of CCR5 inhibitors. JF - Antimicrobial Agents & Chemotherapy AU - Nakata, Hirotomo AU - Steinberg, Seth M AU - Koh, Yasuhiro AU - Maeda, Kenji AU - Takaoka, Yoshikazu AU - Tamamura, Hirokazu AU - Fujii, Nobutaka AU - Mitsuya, Hiroaki AD - Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Departments of Infectious Diseases and Hematology, Kumamoto 860-8556, Japan. Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Ono Pharmaceutical Co. Ltd., Osaka 618-8585, Japan. Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 2111 EP - 2119 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Data processing KW - Statistics KW - Indinavir KW - CXCR4 protein KW - Food KW - Statistical analysis KW - Zidovudine KW - Drug development KW - CCR5 protein KW - Infection KW - Antiviral activity KW - Enfuvirtide KW - Models KW - Nevirapine KW - Antiviral agents KW - Human immunodeficiency virus KW - Human immunodeficiency virus 1 KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20050380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Potent+Synergistic+Anti-Human+Immunodeficiency+Virus+%28HIV%29+Effects+Using+Combinations+of+the+CCR5+Inhibitor+Aplaviroc+with+Other+Anti-HIV+Drugs&rft.au=Nakata%2C+Hirotomo%3BSteinberg%2C+Seth+M%3BKoh%2C+Yasuhiro%3BMaeda%2C+Kenji%3BTakaoka%2C+Yoshikazu%3BTamamura%2C+Hirokazu%3BFujii%2C+Nobutaka%3BMitsuya%2C+Hiroaki&rft.aulast=Nakata&rft.aufirst=Hirotomo&rft.date=2008-06-01&rft.volume=52&rft.issue=6&rft.spage=2111&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Statistics; Data processing; CXCR4 protein; Indinavir; Food; Statistical analysis; Zidovudine; CCR5 protein; Drug development; Antiviral activity; Infection; Enfuvirtide; Models; Nevirapine; Antiviral agents; Drugs; Human immunodeficiency virus; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Analysis of genomic tRNA sets from Bacteria, Archaea, and Eukarya points to anticodon-codon hydrogen bonds as a major determinant of tRNA compositional variations AN - 20031199; 8304765 AB - Analysis of 100 complete sets of the cytoplasmic elongator tRNA genes from Bacteria, Archaea, and Eukarya pointed to correspondences between types of anticodon and composition of the rest of the tRNA body. The number of the hydrogen bonds formed between the complementary nucleotides in the anticodon-codon duplex appeared as a major quantitative parameter determining covariations in all three domains of life. Our analysis has supported and advanced the "extended anticodon" concept that is based on the argument that the decoding performance of the anticodon is enhanced by selection of a matching anticodon stem-loop sequence, as reported by Yarus in 1982. In addition to the anticodon stem-loop, we have found covariations between the anticodon nucleotides and the composition of the distant regions of their respective tRNAs that include dihydrouridine (D) and thymidyl (T) stem-loops. The majority of the covariable tRNA positions were found at the regions with the increased dynamic potential-such as stem-loop and stem-stem junctions. The consistent occurrences of the covariations on the multigenomic level suggest that the number and pattern of the hydrogen bonds in the anticodon-codon duplex constitute a major factor in the course of translation that is reflected in the fine-tuning of the tRNA composition and structure. JF - RNA AU - Targanski, Ilia AU - Cherkasova, Vera AD - BioLing, Inc., Rockville, Maryland 20853, USA. Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1095 EP - 1109 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 14 IS - 6 SN - 1355-8382, 1355-8382 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids KW - Translation KW - Archaea KW - RNA KW - Anticodons KW - Hydrogen bonding KW - tRNA KW - genomics KW - Nucleotides KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20031199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=RNA&rft.atitle=Analysis+of+genomic+tRNA+sets+from+Bacteria%2C+Archaea%2C+and+Eukarya+points+to+anticodon-codon+hydrogen+bonds+as+a+major+determinant+of+tRNA+compositional+variations&rft.au=Targanski%2C+Ilia%3BCherkasova%2C+Vera&rft.aulast=Targanski&rft.aufirst=Ilia&rft.date=2008-06-01&rft.volume=14&rft.issue=6&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=RNA&rft.issn=13558382&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Translation; RNA; Hydrogen bonding; Anticodons; tRNA; genomics; Nucleotides; Archaea ER - TY - JOUR T1 - In Vivo Efficacy of b-Cyclodextrin Derivatives against Anthrax Lethal Toxin AN - 20008334; 8299563 AB - We evaluated the in vivo efficacy of three b-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described b-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection. JF - Antimicrobial Agents & Chemotherapy AU - Moayeri, Mahtab AU - Robinson, Tanisha M AU - Leppla, Stephen H AU - Karginov, Vladimir A AD - Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. Innovative Biologics, Inc., 13455 Sunrise Valley Dr., Suite 200, Herndon, Virginia 20171 Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 2239 EP - 2241 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 6 SN - 0066-4804, 0066-4804 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Anthrax lethal toxin KW - Pores KW - protective antigen KW - b-Cyclodextrin KW - Animal models KW - Anthrax KW - Infection KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - X 24370:Natural Toxins KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20008334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vivo+Efficacy+of+b-Cyclodextrin+Derivatives+against+Anthrax+Lethal+Toxin&rft.au=Moayeri%2C+Mahtab%3BRobinson%2C+Tanisha+M%3BLeppla%2C+Stephen+H%3BKarginov%2C+Vladimir+A&rft.aulast=Moayeri&rft.aufirst=Mahtab&rft.date=2008-06-01&rft.volume=52&rft.issue=6&rft.spage=2239&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Pores; protective antigen; Animal models; b-Cyclodextrin; Anthrax; Infection; Drugs ER - TY - JOUR T1 - Ultrasound mediated delivery of drugs and genes to solid tumors AN - 19907478; 8769272 AB - It has long been shown that therapeutic ultrasound can be used effectively to ablate solid tumors, and a variety of cancers are presently being treated in the clinic using these types of ultrasound exposures. There is, however, an ever-increasing body of preclinical literature that demonstrates how ultrasound energy can also be used non-destructively for increasing the efficacy of drugs and genes for improving cancer treatment. In this review, a summary of the most important ultrasound mechanisms will be given with a detailed description of how each one can be employed for a variety of applications. This includes the manner by which acoustic energy deposition can be used to create changes in tissue permeability for enhancing the delivery of conventional agents, as well as for deploying and activating drugs and genes via specially tailored vehicles and formulations. JF - Advanced Drug Delivery Reviews AU - Frenkel, Victor AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Building 10, Room 1N306a, 10 Center Drive, Bethesda, MD 20892, USA, vfrenkel@cc.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1193 EP - 1208 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 60 IS - 10 SN - 0169-409X, 0169-409X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - High intensity focused ultrasound (HIFU) KW - Drug and gene delivery KW - Hyperthermia KW - Acoustic cavitation KW - Acoustic radiation forces KW - Drug delivery KW - Permeability KW - Solid tumors KW - Acoustics KW - Energy KW - Ultrasound KW - Cancer KW - G 07880:Human Genetics KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19907478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Ultrasound+mediated+delivery+of+drugs+and+genes+to+solid+tumors&rft.au=Frenkel%2C+Victor&rft.aulast=Frenkel&rft.aufirst=Victor&rft.date=2008-06-01&rft.volume=60&rft.issue=10&rft.spage=1193&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2008.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Permeability; Drug delivery; Acoustics; Solid tumors; Energy; Ultrasound; Cancer DO - http://dx.doi.org/10.1016/j.addr.2008.03.007 ER - TY - JOUR T1 - How Does Tobacco Smoke Contribute to Cervical Carcinogenesis? AN - 19895922; 8303693 JF - Journal of Virology AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics , National Cancer Institute , 6120 Executive Blvd., Room 5004, MSC 7234 , Bethesda, Maryland 20892-7234, castlep@mail.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 6084 EP - 6086 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 82 IS - 12 SN - 0022-538X, 0022-538X KW - Toxicology Abstracts; Virology & AIDS Abstracts KW - Smoke KW - Carcinogenesis KW - Tobacco KW - Cervix KW - X 24380:Social Poisons & Drug Abuse KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=How+Does+Tobacco+Smoke+Contribute+to+Cervical+Carcinogenesis%3F&rft.au=Castle%2C+Philip+E&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-06-01&rft.volume=82&rft.issue=12&rft.spage=6084&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Smoke; Carcinogenesis; Tobacco; Cervix ER - TY - JOUR T1 - Isobolographic Analysis of Pharmacodynamic Interactions between Antifungal Agents and Ciprofloxacin against Candida albicans and Aspergillus fumigatus AN - 19884399; 8299555 AB - Patients suffering from invasive mycoses often receive concomitant antifungal therapy and antibacterial agents. Assessment of pharmacodynamic interactions between antifungal and antibacterial agents is complicated by the absence of a common antifungal end point for both agents. Ciprofloxacin has no intrinsic antifungal activity but may interact with antifungal agents, since it inhibits DNA gyrase (topoisomerase II), which is abundant in fungi. We therefore employed isobolographic analysis adapted to incorporate a nonactive agent in order to analyze the potential in vitro interaction between the fluoroquinolone ciprofloxacin and several representative antifungal agents against Candida albicans and Aspergillus fumigatus strains by using a microdilution checkerboard technique. In agreement with earlier in vitro studies, conventional fractional inhibitory concentration index analysis was unable to detect interactions between ciprofloxacin and antifungal agents. However, isobolographic analysis revealed significant pharmacodynamic interactions between antifungal agents and ciprofloxacin against C. albicans and A. fumigatus strains. Amphotericin B demonstrated concentration-dependent interactions for both species, with synergy (interaction indices, 0.14 to 0.81) observed at ciprofloxacin concentrations of <10.64 kg/ml. Synergy (interaction indices, 0.10 to 0.86) was also found for voriconazole and caspofungin against A. fumigatus. Isobolographic analysis may help to elucidate the pharmacodynamic interactions between antifungal and non-antifungal agents and to develop better management strategies against invasive candidiasis and aspergillosis. JF - Antimicrobial Agents & Chemotherapy AU - Stergiopoulou, Theodouli AU - Meletiadis, Joseph AU - Sein, Tin AU - Papaioannidou, Paraskevi AU - Tsiouris, Ioannis AU - Roilides, Emmanuel AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, Clinical Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. SAIC-Frederick, Inc., Frederick, Maryland 21702. Department of Pharmacology, Medical Faculty, Aristotle University. 3rd Pediatric Department, Aristotle University, Hippokration Hospital, Thessaloniki, Greece Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 2196 EP - 2204 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Amphotericin B KW - Antifungal agents KW - Candidiasis KW - Fluoroquinolones KW - Fungi KW - Caspofungin KW - DNA topoisomerase KW - Aspergillosis KW - Candida albicans KW - Ciprofloxacin KW - Aspergillus fumigatus KW - Voriconazole KW - Antifungal activity KW - DNA topoisomerase (ATP-hydrolysing) KW - Antibacterial agents KW - Pharmacodynamics KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19884399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Isobolographic+Analysis+of+Pharmacodynamic+Interactions+between+Antifungal+Agents+and+Ciprofloxacin+against+Candida+albicans+and+Aspergillus+fumigatus&rft.au=Stergiopoulou%2C+Theodouli%3BMeletiadis%2C+Joseph%3BSein%2C+Tin%3BPapaioannidou%2C+Paraskevi%3BTsiouris%2C+Ioannis%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Stergiopoulou&rft.aufirst=Theodouli&rft.date=2008-06-01&rft.volume=52&rft.issue=6&rft.spage=2196&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Antifungal agents; Fluoroquinolones; Candidiasis; Fungi; Caspofungin; DNA topoisomerase; Aspergillosis; Ciprofloxacin; Antifungal activity; Voriconazole; DNA topoisomerase (ATP-hydrolysing); Antibacterial agents; Pharmacodynamics; Aspergillus fumigatus; Candida albicans ER - TY - JOUR T1 - Synthesis of beta -(S-methyl)thioaspartic acid and derivatives AN - 19805337; 8807981 AB - beta -(S-Methyl)thioaspartic acid occurs as a posttranslational modification at position 88 in Escherichia coli ribosomal protein S12, a position that is a mutational hotspot resulting in both antibiotic-resistant and antibiotic-sensitive phenotypes. Critical to research designed to determine the biological function of beta -(S-methyl)thioaspartic acid will be the availability of synthetic beta -(S-methyl)thioaspartic acid as well as derivatives designed for peptide incorporation. We report here the synthesis of beta -(S-methyl)thioaspartic acid and derivatives. The installation of the beta -methylthio moiety into the aspartic acid structure was accomplished by electrophilic sulfenylation of N-protected-l-aspartic acid derivatives with 2,4-dinitrophenyl methyl disulfide. Following this key transformation, we were able to prepare protected beta -(S- methyl)thioaspartic acid derivative suitable for peptide coupling. JF - Bioorganic and Medicinal Chemistry AU - Heredia-Moya, Jorge AU - Kirk, Kenneth L AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA, kennethk@bdg8.niddk.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 5908 EP - 5913 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 11 SN - 0968-0896, 0968-0896 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Transformation KW - ribosomal protein S12 KW - Aspartic acid KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19805337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+of+beta+-%28S-methyl%29thioaspartic+acid+and+derivatives&rft.au=Heredia-Moya%2C+Jorge%3BKirk%2C+Kenneth+L&rft.aulast=Heredia-Moya&rft.aufirst=Jorge&rft.date=2008-06-01&rft.volume=16&rft.issue=11&rft.spage=5908&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.04.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transformation; Aspartic acid; ribosomal protein S12; Escherichia coli DO - http://dx.doi.org/10.1016/j.bmc.2008.04.069 ER - TY - JOUR T1 - Synthesis and potency of novel uracil nucleotides and derivatives as P2Y sub(2) and P2Y sub(6) receptor agonists AN - 19725287; 8808036 AB - The phosphate, uracil, and ribose moieties of uracil nucleotides were varied structurally for evaluation of agonist activity at the human P2Y sub(2), P2Y sub(4), and P2Y sub(6) receptors. The 2-thio modification, found previously to enhance P2Y sub(2) receptor potency, could be combined with other favorable modifications to produce novel molecules that exhibit high potencies and receptor selectivities. Phosphonomethylene bridges introduced for stability in analogues of UDP, UTP, and uracil dinucleotides markedly reduced potency. Truncation of dinucleotide agonists of the P2Y sub(2) receptor, in the form of Up sub(4)-sugars, indicated that a terminal uracil ring is not essential for moderate potency at this receptor and that specific SAR patterns are observed at this distal end of the molecule. Key compounds reported in this study include 9, alpha , beta -methylene-UDP, a P2Y sub(6) receptor agonist; 30, Up sub(4)- phenyl ester and 34, Up sub(4)-[1]glucose, selective P2Y sub(2) receptor agonists; dihalomethylene phosphonate analogues 16 and 41, selective P2Y sub(2) receptor agonists; 43, the 2-thio analogue of INS37217 (P super(1)- (uridine-5')-P super(4)-(2'-deoxycytidine-5')tetraphosphate), a potent and selective P2Y sub(2) receptor agonist. JF - Bioorganic and Medicinal Chemistry AU - Ko, Hyojin AU - Carter, Rhonda L AU - Cosyn, Liesbet AU - Petrelli, Riccardo AU - De Castro, Sonia AU - Besada, Pedro AU - Zhou, Yixing AU - Cappellacci, Loredana AU - Franchetti, Palmarisa AU - Grifantini, Mario AU - Van Calenbergh, Serge AU - Harden, TKendall AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-0810, USA, kajacobs@helix.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 6319 EP - 6332 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 12 SN - 0968-0896, 0968-0896 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - phosphonates KW - Phosphate KW - Uracil KW - Purine P2Y receptors KW - Ribose KW - Esters KW - Nucleotides KW - N 14840:Antisense, Nucleotide Analogs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19725287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+and+potency+of+novel+uracil+nucleotides+and+derivatives+as+P2Y+sub%282%29+and+P2Y+sub%286%29+receptor+agonists&rft.au=Ko%2C+Hyojin%3BCarter%2C+Rhonda+L%3BCosyn%2C+Liesbet%3BPetrelli%2C+Riccardo%3BDe+Castro%2C+Sonia%3BBesada%2C+Pedro%3BZhou%2C+Yixing%3BCappellacci%2C+Loredana%3BFranchetti%2C+Palmarisa%3BGrifantini%2C+Mario%3BVan+Calenbergh%2C+Serge%3BHarden%2C+TKendall%3BJacobson%2C+Kenneth+A&rft.aulast=Ko&rft.aufirst=Hyojin&rft.date=2008-06-01&rft.volume=16&rft.issue=12&rft.spage=6319&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.05.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - phosphonates; Phosphate; Uracil; Ribose; Purine P2Y receptors; Esters; Nucleotides DO - http://dx.doi.org/10.1016/j.bmc.2008.05.013 ER - TY - JOUR T1 - nuScore: a web-interface for nucleosome positioning predictions AN - 19707245; 8300511 AB - SUMMARY: Sequence-directed mapping of nucleosome positions is of major biological interest. Here, we present a web-interface for estimation of the affinity of the histone core to DNA and prediction of nucleosome arrangement on a given sequence. Our approach is based on assessment of the energy cost of imposing the deformations required to wrap DNA around the histone surface. The interface allows the user to specify a number of options such as selecting from several structural templates for threading calculations and adding random sequences to the analysis. AVAILABILITY: The nuScore interface is freely available for use at http://compbio.med.harvard.edu/nuScore. Supplementary information: The site contains user manual, description of the methodology and examples. JF - Bioinformatics AU - Tolstorukov, Michael Y AU - Choudhary, Vidhu AU - Olson, Wilma K AU - Zhurkin, Victor B AU - Park, Peter J AD - Harvard-Partners Center for Genetics and Genomics, Brigham and Women's Hospital, Boston, MA 02115, Children Hospital Informatics Program, Boston, MA 02115, Wright-Rieman Laboratories, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 and Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA, peter_park@harvard.edu Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1456 EP - 1458 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 24 IS - 12 SN - 1367-4803, 1367-4803 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Nucleosomes KW - Histones KW - Nucleotide sequence KW - Energy KW - DNA KW - Mapping KW - Bioinformatics KW - N 14820:DNA Metabolism & Structure KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19707245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=nuScore%3A+a+web-interface+for+nucleosome+positioning+predictions&rft.au=Tolstorukov%2C+Michael+Y%3BChoudhary%2C+Vidhu%3BOlson%2C+Wilma+K%3BZhurkin%2C+Victor+B%3BPark%2C+Peter+J&rft.aulast=Tolstorukov&rft.aufirst=Michael&rft.date=2008-06-01&rft.volume=24&rft.issue=12&rft.spage=1456&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nucleosomes; Histones; Energy; Nucleotide sequence; DNA; Bioinformatics; Mapping ER - TY - JOUR T1 - Medical Countermeasures for Radiation Combined Injury: Radiation with Burn, Blast, Trauma and/or Sepsis. Report of an NIAID Workshop, March 26-27, 2007 AN - 19655358; 8693574 AB - DiCarlo, A. L., Hatchett, R. J., Kaminski, J. M., Ledney, G. D., Pellmar, T. C., Okunieff, P. and Ramakrishnan, N. Medical Countermeasures for Radiation Combined Injury: Radiation with Burn, Blast, Trauma and/or Sepsis. Report of an NIAID Workshop, March 26-27, 2007. Radiat. Res. 169, 712-721 (2008). Non-clinical human radiation exposure events such as the Hiroshima and Nagasaki bombings or the Chernobyl accident are often coupled with other forms of injury, such as wounds, burns, blunt trauma, and infection. Radiation combined injury would also be expected after a radiological or nuclear attack. Few animal models of radiation combined injury exist, and mechanisms underlying the high mortality associated with complex radiation injuries are poorly understood. Medical countermeasures are currently available for management of the non-radiation components of radiation combined injury, but it is not known whether treatments for other insults will be effective when the injury is combined with radiation exposure. Further research is needed to elucidate mechanisms behind the synergistic lethality of radiation combined injury and to identify targets for medical countermeasures. To address these issues, the National Institute of Allergy and Infectious Diseases convened a workshop to make recommendations on the development of animal models of radiation combined injury, possible mechanisms of radiation combined injury, and future directions for countermeasure research, including target identification and end points to evaluate treatment efficacy. JF - Radiation Research AU - DiCarlo, Andrea L AU - Hatchett, Richard J AU - Kaminski, Joseph M AU - Ledney, GDavid AU - Pellmar, Terry C AU - Okunieff, Paul AU - Ramakrishnan, Narayani AD - Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, cohena@niaid.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 712 EP - 721 PB - Allen Press, Inc., 810 East Tenth St. VL - 169 IS - 6 SN - 0033-7587, 0033-7587 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Burns KW - Mortality KW - Conferences KW - Injuries KW - Animal models KW - Infection KW - Wounds KW - Trauma KW - Accidents KW - Hypersensitivity KW - Sepsis KW - Lethality KW - Infectious diseases KW - Blast KW - X 24390:Radioactive Materials KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19655358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Medical+Countermeasures+for+Radiation+Combined+Injury%3A+Radiation+with+Burn%2C+Blast%2C+Trauma+and%2For+Sepsis.+Report+of+an+NIAID+Workshop%2C+March+26-27%2C+2007&rft.au=DiCarlo%2C+Andrea+L%3BHatchett%2C+Richard+J%3BKaminski%2C+Joseph+M%3BLedney%2C+GDavid%3BPellmar%2C+Terry+C%3BOkunieff%2C+Paul%3BRamakrishnan%2C+Narayani&rft.aulast=DiCarlo&rft.aufirst=Andrea&rft.date=2008-06-01&rft.volume=169&rft.issue=6&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1295.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Burns; Mortality; Injuries; Conferences; Animal models; Infection; Trauma; Wounds; Sepsis; Hypersensitivity; Accidents; Lethality; Infectious diseases; Blast DO - http://dx.doi.org/10.1667/RR1295.1 ER - TY - JOUR T1 - A Mechanism for the Inhibition of Neural Progenitor Cell Proliferation by Cocaine AN - 19580976; 8520611 AB - Prenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that cocaine-induced proliferation inhibition and/or apoptosis in neural progenitor cells may play a pivotal role in causing these abnormalities. To understand the molecular mechanism through which cocaine inhibits cell proliferation in neural progenitors, we sought to identify the molecules that are responsible for mediating the effect of cocaine on cell cycle regulation. Methods and Findings Microarray analysis followed by quantitative real-time reverse transcription PCR was used to screen cocaine-responsive and cell cycle-related genes in a neural progenitor cell line where cocaine exposure caused a robust anti-proliferative effect by interfering with the G1-to-S transition. Cyclin A2, among genes related to the G1-to-S cell cycle transition, was most strongly down-regulated by cocaine. Down-regulation of cyclin A was also found in cocaine-treated human primary neural and A2B5+ progenitor cells, as well as in rat fetal brains exposed to cocaine in utero. Reversing cyclin A down-regulation by gene transfer counteracted the proliferation inhibition caused by cocaine. Further, we found that cocaine-induced accumulation of reactive oxygen species, which involves N-oxidation of cocaine via cytochrome P450, promotes cyclin A down-regulation by causing an endoplasmic reticulum (ER) stress response, as indicated by increased phosphorylation of eIF2a and expression of ATF4. In the developing rat brain, the P450 inhibitor cimetidine counteracted cocaine-induced inhibition of neural progenitor cell proliferation as well as down-regulation of cyclin A. Conclusions Our results demonstrate that down-regulation of cyclin A underlies cocaine-induced proliferation inhibition in neural progenitors. The down-regulation of cyclin A is initiated by N-oxidative metabolism of cocaine and consequent ER stress. Inhibition of cocaine N-oxidative metabolism by P450 inhibitors may provide a preventive strategy for counteracting the adverse effects of cocaine on fetal brain development. Investigating the mechanism of cocaine's effect on fetal brain development, Chun-Ting Lee and colleagues find that down-regulation of cyclin A by a cocaine metabolite inhibits neural proliferation. Editors' Summary Background. Every year, cocaine abuse by mothers during pregnancy exposes thousands of unborn infants (fetuses) to this powerful and addictive stimulant. Maternal cocaine abuse during early pregnancy increases the risk of miscarriage; its use during late pregnancy slows the baby's growth and can trigger premature labor. Babies exposed to cocaine shortly before birth are often irritable and have disturbed sleep patterns. They can also be very sensitive to sound and touch and consequently hard to comfort. These problems usually resolve spontaneously within the first few weeks of life but some permanent birth defects are also associated with frequent cocaine abuse during pregnancy. In particular, babies exposed to cocaine before birth sometimes have small heads-an abnormality that generally indicates a small brain-and, although they usually have normal intelligence, the development of their thinking skills and language is often delayed, and they can have behavioral problems. JF - PLOS Medicine AU - Lee, Chun-Ting AU - Chen, Jia AU - Hayashi, Teruo AU - Tsai, Shang-Yi AU - Sanchez, Joseph F AU - Errico, Stacie L AU - Amable, Rose AU - Su, Tsung-Ping AU - Lowe, Ross H AU - Huestis, Marilyn A AU - Shen, James AU - Becker, Kevin G AU - Geller, Herbert M AU - Freed, William J AU - Graeber, Manuel AD - Cellular Neurobiology Research Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Baltimore, Maryland, United States of America Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 5 IS - 6 SN - 1549-1277, 1549-1277 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Molecular modelling KW - Prenatal experience KW - Abortion KW - Cell cycle KW - Metabolites KW - Drug abuse KW - Reverse transcription KW - Expression vectors KW - Endoplasmic reticulum KW - Reactive oxygen species KW - Sound KW - Cocaine KW - Neural stem cells KW - Cimetidine KW - Cyclins KW - Brain KW - Stress KW - Toxicity KW - Fetuses KW - Pregnancy KW - Cyclin A KW - Cell division KW - Neurons KW - Tactile stimuli KW - Initiation factor eIF-2 KW - Cytochrome P450 KW - Cell proliferation KW - Side effects KW - Metabolism KW - Infants KW - X 24380:Social Poisons & Drug Abuse KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLOS+Medicine&rft.atitle=A+Mechanism+for+the+Inhibition+of+Neural+Progenitor+Cell+Proliferation+by+Cocaine&rft.au=Lee%2C+Chun-Ting%3BChen%2C+Jia%3BHayashi%2C+Teruo%3BTsai%2C+Shang-Yi%3BSanchez%2C+Joseph+F%3BErrico%2C+Stacie+L%3BAmable%2C+Rose%3BSu%2C+Tsung-Ping%3BLowe%2C+Ross+H%3BHuestis%2C+Marilyn+A%3BShen%2C+James%3BBecker%2C+Kevin+G%3BGeller%2C+Herbert+M%3BFreed%2C+William+J%3BGraeber%2C+Manuel&rft.aulast=Lee&rft.aufirst=Chun-Ting&rft.date=2008-06-01&rft.volume=5&rft.issue=6&rft.spage=e117&rft.isbn=&rft.btitle=&rft.title=PLOS+Medicine&rft.issn=15491277&rft_id=info:doi/10.1371%2Fjournal.pmed.0050117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Prenatal experience; Abortion; Cell cycle; Metabolites; Drug abuse; Reverse transcription; Expression vectors; Endoplasmic reticulum; Reactive oxygen species; Sound; Cocaine; Cimetidine; Neural stem cells; Cyclins; Brain; Stress; Toxicity; Fetuses; Pregnancy; Cyclin A; Cell division; Neurons; Tactile stimuli; Cytochrome P450; Initiation factor eIF-2; Cell proliferation; Metabolism; Side effects; Infants DO - http://dx.doi.org/10.1371/journal.pmed.0050117 ER - TY - JOUR T1 - Genetic susceptibility to occupational exposures AN - 19529742; 8202630 AB - Because of their high prevalence in the general population, genetic variants that determine susceptibility to environmental exposures may contribute greatly to the development of occupational diseases in the setting of specific exposures occurring in the workplace. Studies investigating genetic susceptibilities in the workplace may: (1) provide mechanistic insight into the aetiology of disease, in particular the determination of environmentally responsive genes; (2) identify susceptible subpopulations with respect to exposure; and (3) provide valuable input in setting occupational exposure limits by taking genetic susceptibility into account. Polymorphisms in the NAT2 and the HLA-DPB1 super(G) super(lu69) genes provide classic examples of how genetic susceptibility markers have a clear role in identifying disease risk in bladder cancer and chronic beryllium disease, respectively. For diseases with more complex and multifactorial aetiology such as occupational asthma and chronic airways disease, susceptibility studies for selected genetic polymorphisms provide additional insight into the biological mechanisms of disease. Even when polymorphisms for genetic susceptibility have a clear role in identifying disease risk, the value of wide scale genetic screening in occupational settings remains limited due to primarily ethical and social concerns. Thus, large scale genetic screening in the workplace is not currently recommended. JF - Occupational and Environmental Medicine AU - Christiani, D C AU - Mehta, A J AU - Yu, C-L AD - Environmental and Occupational Medicine and Epidemiology Program, Harvard School of Public Health, Boston, Massachusetts, USA Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 430 EP - 436 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 6 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Genetics Abstracts; Health & Safety Science Abstracts KW - Berylliosis KW - Histocompatibility antigen HLA KW - Urinary bladder KW - Occupational diseases KW - Subpopulations KW - Gene polymorphism KW - Asthma KW - Respiratory diseases KW - Cancer KW - population genetics KW - urinary bladder KW - Genetics KW - Respiratory tract diseases KW - Population genetics KW - occupational diseases KW - subpopulations KW - Ethics KW - Beryllium KW - Genetic screening KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19529742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Genetic+susceptibility+to+occupational+exposures&rft.au=Christiani%2C+D+C%3BMehta%2C+A+J%3BYu%2C+C-L&rft.aulast=Christiani&rft.aufirst=D&rft.date=2008-06-01&rft.volume=65&rft.issue=6&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Berylliosis; Occupational diseases; Urinary bladder; Gene polymorphism; Subpopulations; Asthma; Cancer; Population genetics; Respiratory tract diseases; Ethics; Genetic screening; Occupational exposure; Genetics; urinary bladder; population genetics; subpopulations; occupational diseases; Beryllium; Respiratory diseases ER - TY - JOUR T1 - Assessment of Stromal-Derived Inducing Activity in the Generation of Dopaminergic Neurons from Human Embryonic Stem Cells AN - 19477851; 8305126 AB - Producing dopaminergic (DA) neurons is a major goal of human embryonic stem cell (hESC) research. DA neurons can be differentiated from hESC by coculture with the mouse PA6 stromal cell line; this differentiation-inducing effect is termed stromal-derived inducing activity (SDIA). The molecular and biochemical nature of SDIA is, however, unknown. Various studies have suggested that SDIA involves either a fixation-resistant component located on the PA6 cell surface or factors secreted into the medium by PA6 cells. To address this question, hESC were cocultured with PA6 cells for 12 days and then further differentiated with sonic hedgehog homolog, fibroblast growth factor-8, and glial cell line-derived neurotrophic factor. After 18 days, 34% of cells were tyrosine hydroxylase (TH)+. When PA6 cells were fixed or irradiated, the number of TH+ cells was decreased by threefold, whereas mitomycin-c treatment of feeder cells decreased the number of TH+ cells by 32%. The neural-inducing effect of PA6 cells, as monitored by beta -III-tubulin expression, was minimally affected by mitomycin-c treatment or fixation but was decreased 50% by irradiation. Medium conditioned by PA6 cells was ineffective in differentiating TH+ cells when used alone. Conditioned medium combined with heparin and/or fixed PA6 cells produced TH+ cell differentiation, although less effectively than PA6 cell coculture. Thus, PA6 cell surface activity is required for neural differentiation of hESC, but secreted factors are required for the specific DA neuron-inducing effect. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Vazin, Tandis AU - Chen, Jia AU - Lee, Chun-Ting AU - Amable, Rose AU - Freed, William J AD - Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1517 EP - 1525 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 6 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Cell surface KW - stromal cells KW - Glial cell line-derived neurotrophic factor KW - Cell culture KW - Mitomycin C KW - Differentiation KW - Neurogenesis KW - Stem cells KW - Hedgehog protein KW - Dopamine KW - Radiation KW - Embryo cells KW - Neurons KW - Tyrosine 3-monooxygenase KW - Heparin KW - N3 11001:Behavioral and Cognitive Neuroscience KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Assessment+of+Stromal-Derived+Inducing+Activity+in+the+Generation+of+Dopaminergic+Neurons+from+Human+Embryonic+Stem+Cells&rft.au=Vazin%2C+Tandis%3BChen%2C+Jia%3BLee%2C+Chun-Ting%3BAmable%2C+Rose%3BFreed%2C+William+J&rft.aulast=Vazin&rft.aufirst=Tandis&rft.date=2008-06-01&rft.volume=26&rft.issue=6&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; stromal cells; Glial cell line-derived neurotrophic factor; Cell culture; Mitomycin C; Differentiation; Hedgehog protein; Stem cells; Neurogenesis; Dopamine; Embryo cells; Radiation; Neurons; Tyrosine 3-monooxygenase; Heparin ER - TY - JOUR T1 - Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy AN - 19477418; 8343392 AB - Pharmacotherapy of central nervous system (CNS) disorders (e.g., neurodegenerative diseases, epilepsy, brain cancer, and neuro-AIDS) is limited by the blood-brain barrier. P-glycoprotein, an ATP-driven, drug efflux transporter, is a critical element of that barrier. High level of expression, luminal membrane location, multispecificity, and high transport potency make P-glycoprotein a selective gatekeeper of the blood-brain barrier and thus a primary obstacle to drug delivery into the brain. As such, P-glycoprotein limits entry into the CNS for a large number of prescribed drugs, contributes to the poor success rate of CNS drug candidates, and probably contributes to patient-to-patient variability in response to CNS pharmacotherapy. Modulating P-glycoprotein could therefore improve drug delivery into the brain. Here we review the current understanding of signaling mechanisms responsible for the modulation of P-glycoprotein activity/expression at the blood-brain barrier with an emphasis on recent studies from our laboratories. Using intact brain capillaries from rats and mice, we have identified multiple extracellular and intracellular signals that regulate this transporter; several signaling pathways have been mapped. Three pathways are triggered by elements of the brain's innate immune response, one by glutamate, one by xenobiotic-nuclear receptor (pregnane X receptor) interactions, and one by elevated beta -amyloid levels. Signaling is complex, with several pathways sharing common signaling elements [tumor necrosis factor (TNF) receptor 1, endothelin (ET) B receptor, protein kinase C, and nitric-oxide synthase), suggesting a regulatory network. Several pathways include autocrine/paracrine elements, involving release of the proinflammatory cytokine, TNF- alpha , and the polypeptide hormone, ET-1. Finally, several steps in signaling are potential therapeutic targets that could be used to modulate P-glycoprotein activity in the clinic. JF - Pharmacological Reviews AU - Miller, David S AU - Bauer, Bjoern AU - Hartz, Anika MS AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (D.S.M., B.B., A.M.S.H.) Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 196 EP - 209 PB - American Society for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike Bethesda MD 20814-3995 USA, [mailto:info@aspet.org], [URL:http://www.aspet.org] VL - 60 IS - 2 SN - 0031-6997, 0031-6997 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Protein kinase C KW - Central nervous system KW - Drug delivery KW - Blood-brain barrier KW - Alzheimer's disease KW - Capillaries KW - Hormones KW - Tumor necrosis factor receptors KW - Autocrine signalling KW - P-Glycoprotein KW - Cytokines KW - beta -Amyloid KW - Paracrine signalling KW - Brain KW - Drug development KW - Cancer KW - Endothelin 1 KW - Inflammation KW - Nitric-oxide synthase KW - Neurodegenerative diseases KW - Epilepsy KW - pregnane X receptors KW - Immune response KW - Tumor necrosis factor- alpha KW - Glutamic acid KW - Signal transduction KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+Reviews&rft.atitle=Modulation+of+P-Glycoprotein+at+the+Blood-Brain+Barrier%3A+Opportunities+to+Improve+Central+Nervous+System+Pharmacotherapy&rft.au=Miller%2C+David+S%3BBauer%2C+Bjoern%3BHartz%2C+Anika+MS&rft.aulast=Miller&rft.aufirst=David&rft.date=2008-06-01&rft.volume=60&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Pharmacological+Reviews&rft.issn=00316997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Drug delivery; Central nervous system; Blood-brain barrier; Alzheimer's disease; Hormones; Capillaries; Tumor necrosis factor receptors; P-Glycoprotein; Autocrine signalling; Cytokines; beta -Amyloid; Paracrine signalling; Brain; Drug development; Endothelin 1; Cancer; Inflammation; Nitric-oxide synthase; Neurodegenerative diseases; Epilepsy; Glutamic acid; Tumor necrosis factor- alpha; Immune response; pregnane X receptors; Signal transduction ER - TY - JOUR T1 - The Neuronal Differentiation Potential of Ldb1-Null Mutant Embryonic Stem Cells Is Dependent on Extrinsic Influences AN - 19476465; 8305123 AB - LIM-domain binding protein 1 (Ldb1) is a multiadaptor protein that mediates the action of transcription factors, including LIM-homeodomain proteins. To elucidate the functional role of Ldb1 in the neuronal differentiation of embryonic stem (ES) cells, we have generated Ldb1-null mutant (Ldb1-/-) ES cells and examined neuronal differentiation potentials in vitro using two different neuronal differentiation protocols. When subjected to a five-stage protocol that recapitulates in vivo conditions of neuronal differentiation, wild-type ES cells differentiated into a wide spectrum of neuronal cell types. However, Ldb1-/- ES cells did not differentiate into neuronal cells; instead, they differentiated into sarcomeric alpha -actinin-positive muscle cells. In contrast, when an adherent monolayer culture procedure (which is based on the default mechanism of neural induction and eliminates environmental influences) was applied, both wild-type and Ldb1-/- ES cells differentiated into MAP2-positive mature neurons. Comparison of the results obtained when two different neuronal differentiation protocols were used suggests that Ldb1-/- ES cells have an innate potential to differentiate into neuronal cells, but this potential can be inhibited by environmental influences. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Hwang, Minyoung AU - Gorivodsky, Marat AU - Kim, Minjung AU - Westphal, Heiner AU - Geum, Dongho AD - Graduate School of Medicine, Korea University, Seoul, Korea. Laboratories of Mammalian Genes and Development and Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1490 EP - 1495 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 6 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Differentiation KW - Stem cells KW - Embryo cells KW - Transcription factors KW - Neurons KW - Muscles KW - Cell culture KW - W 30940:Products KW - N3 11003:Developmental neuroscience KW - N 14835:Protein-Nucleic Acids Association KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19476465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=The+Neuronal+Differentiation+Potential+of+Ldb1-Null+Mutant+Embryonic+Stem+Cells+Is+Dependent+on+Extrinsic+Influences&rft.au=Hwang%2C+Minyoung%3BGorivodsky%2C+Marat%3BKim%2C+Minjung%3BWestphal%2C+Heiner%3BGeum%2C+Dongho&rft.aulast=Hwang&rft.aufirst=Minyoung&rft.date=2008-06-01&rft.volume=26&rft.issue=6&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Embryo cells; Neurons; Transcription factors; Muscles; Cell culture ER - TY - JOUR T1 - Invited Commentary: Postmenopausal Unopposed Estrogen and Breast Cancer Risk in the Women's Health Initiative-Before and Beyond AN - 19474813; 8300031 AB - Three large clinical trials provoked major debate when hormone replacement therapy (HRT) did not reduce coronary heart disease in postmenopausal women as expected from observational epidemiologic studies. Less discussion has ensued about breast cancer or other adverse events. In this issue of the Journal, investigators from the Women's Health Initiative (WHI) compare breast cancer findings from the randomized trial of unopposed estrogen with those from the large WHI observational study. This commentary briefly summarizes historical highlights of menopausal hormone use; risk-versus-benefit evaluations; scientific, clinical, and policy influences immediately before and during the WHI trial; breast cancer incidence trends; and the posttrial response in US clinical practice. Factors complicating interpretation of the results include differences in breast cancer risk profiles between women in the trial and those in the observational study cohort as well as heterogeneity in the definitions of menopause and prior use of HRT as applied by the WHI investigators to the two populations. Because millions of women use HRT, it is important to consider how the WHI and other research investigations might contribute to reducing gaps in understanding the relation between HRT and breast cancer risk. JF - American Journal of Epidemiology AU - Linet, Martha S AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 1416 EP - 1420 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 12 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - post-menopause KW - Breast cancer KW - Cardiovascular diseases KW - Females KW - clinical trials KW - hormone replacement therapy KW - estrogens KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19474813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Invited+Commentary%3A+Postmenopausal+Unopposed+Estrogen+and+Breast+Cancer+Risk+in+the+Women%27s+Health+Initiative-Before+and+Beyond&rft.au=Linet%2C+Martha+S&rft.aulast=Linet&rft.aufirst=Martha&rft.date=2008-06-01&rft.volume=167&rft.issue=12&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Historical account; post-menopause; Breast cancer; Females; Cardiovascular diseases; clinical trials; hormone replacement therapy; estrogens ER - TY - JOUR T1 - NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A AN - 19386902; 8636647 AB - Abstract not available. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Chapin, Robert E AU - Adams, Jane AU - Boekelheide, Kim AU - Gray Jr, L Earl AU - Hayward, Simon W AU - Lees, Peter S J AU - McIntyre, Barry S AU - Portier, Kenneth M AU - Schnorr, Teresa M AU - Selevan, Sherry G AU - Vandenbergh, John G AU - Woskie, Susan R AD - Pfizer, Inc., Groton, CT, shelby@niehs.nih.gov Y1 - 2008/06// PY - 2008 DA - Jun 2008 SP - 157 EP - 395 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 83 IS - 3 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Bisphenol A KW - Congenital defects KW - Toxicity KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19386902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=NTP-CERHR+expert+panel+report+on+the+reproductive+and+developmental+toxicity+of+bisphenol+A&rft.au=Chapin%2C+Robert+E%3BAdams%2C+Jane%3BBoekelheide%2C+Kim%3BGray+Jr%2C+L+Earl%3BHayward%2C+Simon+W%3BLees%2C+Peter+S+J%3BMcIntyre%2C+Barry+S%3BPortier%2C+Kenneth+M%3BSchnorr%2C+Teresa+M%3BSelevan%2C+Sherry+G%3BVandenbergh%2C+John+G%3BWoskie%2C+Susan+R&rft.aulast=Chapin&rft.aufirst=Robert&rft.date=2008-06-01&rft.volume=83&rft.issue=3&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.20147 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bisphenol A; Congenital defects; Toxicity DO - http://dx.doi.org/10.1002/bdrb.20147 ER - TY - CPAPER T1 - Should Skin Color Matter in the Decision to Offer Preconception Genetic Screening? T2 - 2008 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2008) AN - 41027880; 4895829 JF - 2008 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2008) AU - Bonham, V L AU - Knerr, S AU - Odunlami, A O Y1 - 2008/05/31/ PY - 2008 DA - 2008 May 31 KW - Skin KW - Genetic screening KW - Color KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41027880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2008%29&rft.atitle=Should+Skin+Color+Matter+in+the+Decision+to+Offer+Preconception+Genetic+Screening%3F&rft.au=Bonham%2C+V+L%3BKnerr%2C+S%3BOdunlami%2C+A+O&rft.aulast=Bonham&rft.aufirst=V&rft.date=2008-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={6D288A34 -D418-4C26-B1AC-8DCEAEA7EA10}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Multiplex Initiative: A Study to Determine Who Seeks Free Multiplex Genetic Susceptibility Testing among a Healthy Population of American Adults T2 - 2008 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2008) AN - 41013588; 4895730 JF - 2008 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2008) AU - McBride, C M AU - Hensley-Alford, S AU - Reid, R AU - Larson, E AU - Baxevanis, A D AU - Brody, L C Y1 - 2008/05/31/ PY - 2008 DA - 2008 May 31 KW - Population genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41013588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2008%29&rft.atitle=The+Multiplex+Initiative%3A+A+Study+to+Determine+Who+Seeks+Free+Multiplex+Genetic+Susceptibility+Testing+among+a+Healthy+Population+of+American+Adults&rft.au=McBride%2C+C+M%3BHensley-Alford%2C+S%3BReid%2C+R%3BLarson%2C+E%3BBaxevanis%2C+A+D%3BBrody%2C+L+C&rft.aulast=McBride&rft.aufirst=C&rft.date=2008-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={6D288A34 -D418-4C26-B1AC-8DCEAEA7EA10}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring the Influence of the Family Social Network on the Psychological Well-Being of Individuals Undergoing Genetic Counseling and Testing for Lynch Syndrome T2 - 2008 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2008) AN - 41010220; 4895722 JF - 2008 European Meeting on Psychosocial Aspects of Genetics (EMPAG 2008) AU - Hadley, D W AU - Ashida, S AU - Kuhn, N R AU - Jenkins, J F AU - McBride, C M AU - Koehly, L M Y1 - 2008/05/31/ PY - 2008 DA - 2008 May 31 KW - Psychology KW - Genetic screening KW - Social interactions KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41010220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2008%29&rft.atitle=Exploring+the+Influence+of+the+Family+Social+Network+on+the+Psychological+Well-Being+of+Individuals+Undergoing+Genetic+Counseling+and+Testing+for+Lynch+Syndrome&rft.au=Hadley%2C+D+W%3BAshida%2C+S%3BKuhn%2C+N+R%3BJenkins%2C+J+F%3BMcBride%2C+C+M%3BKoehly%2C+L+M&rft.aulast=Hadley&rft.aufirst=D&rft.date=2008-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+European+Meeting+on+Psychosocial+Aspects+of+Genetics+%28EMPAG+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={6D288A34 -D418-4C26-B1AC-8DCEAEA7EA10}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Greater than 1% of Contemporary West Africans are Carriers of a Founder Mutation for Severe Recessive Type VIII OI, Which was Presumably Brought to America with the Colonial Slave Trade and Also Occurs in African-Americans T2 - 40th European Human Genetics Conference (ESHG 2008) AN - 41005234; 4888513 JF - 40th European Human Genetics Conference (ESHG 2008) AU - Cabral, W A AU - Barnes, A M AU - Rotimi, C N AU - Brody, L AU - Bailey-Wilson, J E AU - Porter, F D AU - Marini, J C Y1 - 2008/05/31/ PY - 2008 DA - 2008 May 31 KW - Africa KW - Mutation KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41005234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+European+Human+Genetics+Conference+%28ESHG+2008%29&rft.atitle=Greater+than+1%25+of+Contemporary+West+Africans+are+Carriers+of+a+Founder+Mutation+for+Severe+Recessive+Type+VIII+OI%2C+Which+was+Presumably+Brought+to+America+with+the+Colonial+Slave+Trade+and+Also+Occurs+in+African-Americans&rft.au=Cabral%2C+W+A%3BBarnes%2C+A+M%3BRotimi%2C+C+N%3BBrody%2C+L%3BBailey-Wilson%2C+J+E%3BPorter%2C+F+D%3BMarini%2C+J+C&rft.aulast=Cabral&rft.aufirst=W&rft.date=2008-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+European+Human+Genetics+Conference+%28ESHG+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={6D288A34 -D418-4C26-B1AC-8DCEAEA7EA10}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Randomized Dose Comparison of Pamidronate in Children with Types III and IV Osteogenesis Imperfecta: 3 vs 6 Month Cycles T2 - 40th European Human Genetics Conference (ESHG 2008) AN - 41002542; 4887496 JF - 40th European Human Genetics Conference (ESHG 2008) AU - Marini, J C AU - Obafemi, A A AU - Abukhaled, M K AU - Cintas, H L AU - Troendle, J F AU - Letocha, A D AU - Reynolds, J C AU - Paul, S Y1 - 2008/05/31/ PY - 2008 DA - 2008 May 31 KW - Children KW - Bisphosphonates KW - Osteogenesis imperfecta KW - Pamidronic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41002542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+European+Human+Genetics+Conference+%28ESHG+2008%29&rft.atitle=Randomized+Dose+Comparison+of+Pamidronate+in+Children+with+Types+III+and+IV+Osteogenesis+Imperfecta%3A+3+vs+6+Month+Cycles&rft.au=Marini%2C+J+C%3BObafemi%2C+A+A%3BAbukhaled%2C+M+K%3BCintas%2C+H+L%3BTroendle%2C+J+F%3BLetocha%2C+A+D%3BReynolds%2C+J+C%3BPaul%2C+S&rft.aulast=Marini&rft.aufirst=J&rft.date=2008-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+European+Human+Genetics+Conference+%28ESHG+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={6D288A34 -D418-4C26-B1AC-8DCEAEA7EA10}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rescue of a Lethal Murine Model of Methylmalonic Acidemia Using AAV 8 Mediated Gene Therapy T2 - 40th European Human Genetics Conference (ESHG 2008) AN - 40994164; 4888583 JF - 40th European Human Genetics Conference (ESHG 2008) AU - Chandler, R J AU - Venditti, C Y1 - 2008/05/31/ PY - 2008 DA - 2008 May 31 KW - Animal models KW - Gene therapy KW - Adeno-associated virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+European+Human+Genetics+Conference+%28ESHG+2008%29&rft.atitle=Rescue+of+a+Lethal+Murine+Model+of+Methylmalonic+Acidemia+Using+AAV+8+Mediated+Gene+Therapy&rft.au=Chandler%2C+R+J%3BVenditti%2C+C&rft.aulast=Chandler&rft.aufirst=R&rft.date=2008-05-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+European+Human+Genetics+Conference+%28ESHG+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={6D288A34 -D418-4C26-B1AC-8DCEAEA7EA10}&AKey={384D2523-AA39-4B08-A120-38A9AB93 ADA3} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression. AN - 71624995; 18396336 AB - Prion diseases are neurodegenerative infections with gliosis and vacuolation. The mechanisms of degeneration remain unclear, but chemokines may be important. In current experiments CCR1 knock-out (KO) mice succumbed more rapidly to scrapie infection than WT controls. Infected KO mice had upregulation of CCL3, a CCR1 ligand, and CCR5, a receptor with specificity for CCL3. Both infected KO and WT mice had upregulation of CCR5-mediated signaling involving activation of Erk1/2 in astrocytes; however, activation was earlier in KO mice suggesting a role in pathogenesis. In both mouse strains activation of the Erk1/2 pathway may lead to astrocyte dysfunction resulting in neurodegeneration. JF - Journal of neuroimmunology AU - LaCasse, Rachel A AU - Striebel, James F AU - Favara, Cynthia AU - Kercher, Lisa AU - Chesebro, Bruce AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, United States. Y1 - 2008/05/30/ PY - 2008 DA - 2008 May 30 SP - 16 EP - 26 VL - 196 IS - 1-2 SN - 0165-5728, 0165-5728 KW - Aif1 protein, mouse KW - 0 KW - Calcium-Binding Proteins KW - Ccr1 protein, mouse KW - Cytokines KW - Glial Fibrillary Acidic Protein KW - Microfilament Proteins KW - PrPSc Proteins KW - Receptors, CCR1 KW - Receptors, CCR5 KW - Mitogen-Activated Protein Kinase 3 KW - EC 2.7.11.24 KW - Index Medicus KW - Animals KW - Cytokines -- genetics KW - Disease Progression KW - Glial Fibrillary Acidic Protein -- metabolism KW - Disease Models, Animal KW - Enzyme Activation -- physiology KW - Mice KW - Brain -- metabolism KW - Cytokines -- metabolism KW - Glial Fibrillary Acidic Protein -- genetics KW - Mice, Knockout KW - Brain -- pathology KW - Receptors, CCR5 -- genetics KW - Mice, Inbred C57BL KW - Calcium-Binding Proteins -- genetics KW - Calcium-Binding Proteins -- metabolism KW - Receptors, CCR5 -- metabolism KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Receptors, CCR1 -- deficiency KW - Gene Expression Regulation -- physiology KW - PrPSc Proteins -- immunology KW - Prion Diseases -- genetics KW - Prion Diseases -- enzymology KW - Prion Diseases -- chemically induced KW - PrPSc Proteins -- metabolism KW - Prion Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71624995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroimmunology&rft.atitle=Role+of+Erk1%2F2+activation+in+prion+disease+pathogenesis%3A+absence+of+CCR1+leads+to+increased+Erk1%2F2+activation+and+accelerated+disease+progression.&rft.au=LaCasse%2C+Rachel+A%3BStriebel%2C+James+F%3BFavara%2C+Cynthia%3BKercher%2C+Lisa%3BChesebro%2C+Bruce&rft.aulast=LaCasse&rft.aufirst=Rachel&rft.date=2008-05-30&rft.volume=196&rft.issue=1-2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroimmunology&rft.issn=01655728&rft_id=info:doi/10.1016%2Fj.jneuroim.2008.02.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-06-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Neurol. 2003 Nov;54(5):638-46 [14595653] J Virol. 2003 Dec;77(23):12617-29 [14610184] J Neurochem. 2004 Apr;89(2):383-90 [15056282] Oncogene. 2004 Apr 12;23(16):2838-49 [15077147] J Virol. 2004 Jun;78(12):6449-58 [15163738] Microbiol Mol Biol Rev. 2004 Jun;68(2):320-44 [15187187] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9754-8 [8790403] Brain Pathol. 1995 Oct;5(4):459-66 [8974629] Mol Cell Biol. 1997 May;17(5):2401-12 [9111309] Brain Res. 1997 Apr 18;754(1-2):171-80 [9134973] J Exp Med. 1997 Jun 2;185(11):1959-68 [9166425] Brain Res Mol Brain Res. 1998 Jun 1;57(1):1-9 [9630473] Am J Pathol. 1998 Jul;153(1):31-7 [9665462] Brain Pathol. 1998 Jul;8(3):449-57 [9669696] Oncogene. 1998 Jul 30;17(4):527-32 [9696047] Mol Cell Biol. 1999 Jan;19(1):136-46 [9858538] Neuropathol Appl Neurobiol. 1999 Feb;25(1):20-8 [10194772] Clin Microbiol Rev. 2004 Oct;17(4):942-64, table of contents [15489356] Am J Vet Res. 1992 Jun;53(6):883-9 [1352664] J Biol Chem. 1993 Jul 15;268(20):14553-6 [8325833] Dev Biol Stand. 1993;80:61-9 [8270117] J Virol. 1994 Apr;68(4):2383-7 [8139024] Folia Neuropathol. 2005;43(4):311-21 [16416395] Int J Dev Neurosci. 2004 Nov;22(7):497-505 [15465279] Brain Res Mol Brain Res. 1999 Nov 10;73(1-2):17-27 [10581394] J Neurochem. 2000 Jan;74(1):125-33 [10617113] J Virol. 2000 Jan;74(2):828-33 [10623745] J Neurochem. 2001 May;77(4):1058-66 [11359871] J Neurosci. 2001 Jun 15;21(12):4125-33 [11404397] Curr Top Microbiol Immunol. 2001;253:203-17 [11417136] Neuropathol Appl Neurobiol. 2002 Apr;28(2):107-19 [11972797] Brain Res. 2002 May 10;935(1-2):32-9 [12062470] J Biol Chem. 2002 Sep 20;277(38):35282-8 [12084708] J Virol. 2002 Nov;76(21):10905-13 [12368333] Glia. 2002 Nov;40(2):232-9 [12379910] Am J Pathol. 2002 Dec;161(6):2087-98 [12466125] Brain Res Bull. 2003 Jun 30;61(1):99-107 [12788213] Annu Rev Neurosci. 2003;26:267-98 [12704221] Bioessays. 2003 Nov;25(11):1085-95 [14579249] Neuroreport. 1999 Aug 2;10(11):2411-5 [10439473] J Virol. 2004 Dec;78(23):13104-12 [15542662] J Virol. 2004 Dec;78(24):13697-707 [15564479] J Neuroimmunol. 2005 Jan;158(1-2):26-33 [15589034] J Biol Chem. 2005 Jan 14;280(2):1529-34 [15528202] J Neurosci. 2005 Sep 14;25(37):8451-6 [16162927] J Neurochem. 2005 Oct;95(2):584-93 [16135077] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jneuroim.2008.02.009 ER - TY - JOUR T1 - Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity. AN - 71644482; 18507839 AB - Inflammation plays an important role in the pathogenesis of Parkinson's disease (PD) through over-activation of microglia, which consequently causes the excessive production of proinflammatory and neurotoxic factors, and impacts surrounding neurons and eventually induces neurodegeneration. Hence, prevention of microglial over-activation has been shown to be a prime target for the development of therapeutic agents for inflammation-mediated neurodegenerative diseases. For in vitro studies, mesencephalic neuron-glia cultures and reconstituted cultures were used to investigate the molecular mechanism by which FLZ, a squamosamide derivative, mediates anti-inflammatory and neuroprotective effects in both lipopolysaccharide-(LPS)- and 1-methyl-4-phenylpyridinium-(MPP+)-mediated models of PD. For in vivo studies, a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced PD mouse model was used. FLZ showed potent efficacy in protecting dopaminergic (DA) neurons against LPS-induced neurotoxicity, as shown in rat and mouse primary mesencephalic neuronal-glial cultures by DA uptake and tyrosine hydroxylase (TH) immunohistochemical results. The neuroprotective effect of FLZ was attributed to a reduction in LPS-induced microglial production of proinflammatory factors such as superoxide, tumor necrosis factor-alpha (TNF-alpha), nitric oxide (NO) and prostaglandin E2 (PGE2). Mechanistic studies revealed that the anti-inflammatory properties of FLZ were mediated through inhibition of NADPH oxidase (PHOX), the key microglial superoxide-producing enzyme. A critical role for PHOX in FLZ-elicited neuroprotection was further supported by the findings that 1) FLZ's protective effect was reduced in cultures from PHOX-/- mice, and 2) FLZ inhibited LPS-induced translocation of the cytosolic subunit of p47PHOX to the membrane and thus inhibited the activation of PHOX. The neuroprotective effect of FLZ demonstrated in primary neuronal-glial cultures was further substantiated by an in vivo study, which showed that FLZ significantly protected against MPTP-induced DA neuronal loss, microglial activation and behavioral changes. Taken together, our results clearly demonstrate that FLZ is effective in protecting against LPS- and MPTP-induced neurotoxicity, and the mechanism of this protection appears to be due, at least in part, to inhibition of PHOX activity and to prevention of microglial activation. JF - Journal of neuroinflammation AU - Zhang, Dan AU - Hu, Xiaoming AU - Wei, Sung-Jen AU - Liu, Jie AU - Gao, Huiming AU - Qian, Li AU - Wilson, Belinda AU - Liu, Gengtao AU - Hong, Jau-Shyong AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. zhangd2@niehs.nih.gov Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 SP - 21 VL - 5 KW - Antiparkinson Agents KW - 0 KW - Benzeneacetamides KW - Lipopolysaccharides KW - Membrane Glycoproteins KW - Neuroprotective Agents KW - Phenols KW - Reactive Oxygen Species KW - Tumor Necrosis Factor-alpha KW - squamosamide KW - 142750-35-4 KW - Cybb protein, mouse KW - EC 1.6.3.1 KW - NADPH Oxidase KW - neutrophil cytosolic factor 1 KW - Dinoprostone KW - K7Q1JQR04M KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Dinoprostone -- biosynthesis KW - Protein Transport -- drug effects KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Cells, Cultured -- drug effects KW - Mice KW - Mesencephalon -- cytology KW - Tumor Necrosis Factor-alpha -- genetics KW - Membrane Glycoproteins -- deficiency KW - Pregnancy KW - Mice, Knockout KW - Rats KW - Rats, Inbred F344 KW - Mice, Inbred C57BL KW - Lipopolysaccharides -- toxicity KW - Dinoprostone -- genetics KW - Female KW - Male KW - Membrane Glycoproteins -- genetics KW - Benzeneacetamides -- pharmacology KW - Neurons -- metabolism KW - NADPH Oxidase -- deficiency KW - Phenols -- therapeutic use KW - Phenols -- pharmacology KW - Neurons -- drug effects KW - NADPH Oxidase -- antagonists & inhibitors KW - Antiparkinson Agents -- therapeutic use KW - Dopamine -- metabolism KW - Benzeneacetamides -- chemistry KW - Nerve Degeneration -- prevention & control KW - Parkinsonian Disorders -- drug therapy KW - Neuroprotective Agents -- pharmacology KW - Microglia -- physiology KW - Benzeneacetamides -- therapeutic use KW - Phenols -- chemistry KW - Antiparkinson Agents -- pharmacology KW - Neuroprotective Agents -- therapeutic use KW - Microglia -- drug effects KW - NADPH Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71644482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroinflammation&rft.atitle=Squamosamide+derivative+FLZ+protects+dopaminergic+neurons+against+inflammation-mediated+neurodegeneration+through+the+inhibition+of+NADPH+oxidase+activity.&rft.au=Zhang%2C+Dan%3BHu%2C+Xiaoming%3BWei%2C+Sung-Jen%3BLiu%2C+Jie%3BGao%2C+Huiming%3BQian%2C+Li%3BWilson%2C+Belinda%3BLiu%2C+Gengtao%3BHong%2C+Jau-Shyong&rft.aulast=Zhang&rft.aufirst=Dan&rft.date=2008-05-28&rft.volume=5&rft.issue=&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroinflammation&rft.issn=1742-2094&rft_id=info:doi/10.1186%2F1742-2094-5-21 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-22 N1 - Date created - 2008-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] J Biomed Sci. 2000 May-Jun;7(3):241-7 [10810243] Redox Rep. 2001;6(1):27-36 [11333112] Exp Neurol. 2001 Jun;169(2):219-30 [11358437] J Neurosci. 2002 Mar 1;22(5):1763-71 [11880505] J Neurosci. 2002 May 1;22(9):3484-92 [11978825] J Neurochem. 2002 Jun;81(6):1285-97 [12068076] Ann N Y Acad Sci. 2002 May;962:207-11 [12076976] Ann N Y Acad Sci. 2002 May;962:318-31 [12076984] FASEB J. 2002 Sep;16(11):1474-6 [12205053] J Neurochem. 2002 Nov;83(4):973-83 [12421370] Cell Mol Life Sci. 2002 Sep;59(9):1428-59 [12440767] J Pharmacol Exp Ther. 2003 Jan;304(1):1-7 [12490568] J Neurosci. 2003 Feb 15;23(4):1228-36 [12598611] Ann N Y Acad Sci. 2003 Jun;991:272-7 [12846993] Curr Med Chem. 2003 Dec;10(23):2507-16 [14529466] Neurol Sci. 2003 Dec;24 Suppl 5:S265-7 [14652785] J Biol Chem. 2004 Jan 9;279(2):1415-21 [14578353] Clin Chim Acta. 2000 Mar;293(1-2):157-66 [10699430] Adv Exp Med Biol. 1999;468:123-33 [10635024] Curr Pharm Des. 2007;13(18):1925-8 [17584117] Int Ophthalmol Clin. 2007 Spring;47(2):185-97 [17450018] Eur J Pharmacol. 2007 Apr 30;561(1-3):1-6 [17359966] Neuropharmacology. 2007 Feb;52(2):423-9 [17055540] Nat Med. 2006 Sep;12(9):1005-15 [16960575] FASEB J. 2006 May;20(7):906-15 [16675848] Neurobiol Aging. 2005 Dec;26 Suppl 1:94-7 [16198446] Prog Neurobiol. 2005 Jun;76(2):77-98 [16081203] Acta Pharmacol Sin. 2004 Jul;25(7):937-42 [15210069] FASEB J. 2005 Apr;19(6):533-42 [15791003] J Nat Prod. 2004 Nov;67(11):1942-6 [15568797] Glia. 1999 Jun;26(4):344-52 [10383053] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] Oncogene. 1996 Sep 5;13(5):939-46 [8806683] Brain Res. 1989 Jun 12;489(2):247-53 [2501002] Ann Neurol. 1988 Oct;24(4):574-6 [3239957] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Aug;26(4):372-8 [15379259] J Neurosci Res. 2004 Aug 15;77(4):540-51 [15264224] Mol Neurobiol. 2005;31(1-3):295-300 [15953829] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1742-2094-5-21 ER - TY - JOUR T1 - Methamphetamine causes microglial activation in the brains of human abusers. AN - 70785194; 18509037 AB - Methamphetamine is a popular addictive drug whose use is associated with multiple neuropsychiatric adverse events and toxic to the dopaminergic and serotonergic systems of the brain. Methamphetamine-induced neuropathology is associated with increased expression of microglial cells that are thought to participate in either pro-toxic or protective mechanisms in the brain. Although reactive microgliosis has been observed in animal models of methamphetamine neurotoxicity, no study has reported on the status of microglial activation in human methamphetamine abusers. The present study reports on 12 abstinent methamphetamine abusers and 12 age-, gender-, and education-matched control subjects who underwent positron emission tomography using a radiotracer for activated microglia, [(11)C](R)-(1-[2-chlorophenyl]-N-methyl-N-[1-methylpropyl]-3-isoquinoline carboxamide) ([(11)C](R)-PK11195). Compartment analysis was used to estimate quantitative levels of binding potentials of [(11)C](R)-PK11195 in brain regions with dopaminergic and/or serotonergic innervation. The mean levels of [(11)C](R)-PK11195 binding were higher in methamphetamine abusers than those in control subjects in all brain regions (>250% higher; p < 0.01 for all). In addition, the binding levels in the midbrain, striatum, thalamus, and orbitofrontal and insular cortices (p < 0.05) correlated inversely with the duration of methamphetamine abstinence. These results suggest that chronic self-administration of methamphetamine can cause reactive microgliosis in the brains of human methamphetamine abusers, a level of activation that appears to subside over longer periods of abstinence. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Sekine, Yoshimoto AU - Ouchi, Yasuomi AU - Sugihara, Genichi AU - Takei, Nori AU - Yoshikawa, Etsuji AU - Nakamura, Kazuhiko AU - Iwata, Yasuhide AU - Tsuchiya, Kenji J AU - Suda, Shiro AU - Suzuki, Katsuaki AU - Kawai, Masayoshi AU - Takebayashi, Kiyokazu AU - Yamamoto, Shigeyuki AU - Matsuzaki, Hideo AU - Ueki, Takatoshi AU - Mori, Norio AU - Gold, Mark S AU - Cadet, Jean L AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 SP - 5756 EP - 5761 VL - 28 IS - 22 KW - Antineoplastic Agents KW - 0 KW - Carbon Isotopes KW - Central Nervous System Stimulants KW - Isoquinolines KW - Methamphetamine KW - 44RAL3456C KW - PK 11195 KW - YNF83VN1RL KW - Index Medicus KW - Brain Mapping KW - Magnetic Resonance Imaging -- methods KW - Positron-Emission Tomography -- methods KW - Isoquinolines -- pharmacokinetics KW - Protein Binding -- drug effects KW - Humans KW - Antineoplastic Agents -- pharmacokinetics KW - Adult KW - Case-Control Studies KW - Carbon Isotopes -- pharmacokinetics KW - Male KW - Female KW - Methamphetamine -- adverse effects KW - Brain -- pathology KW - Microglia -- diagnostic imaging KW - Amphetamine-Related Disorders -- pathology KW - Amphetamine-Related Disorders -- diagnostic imaging KW - Central Nervous System Stimulants -- adverse effects KW - Amphetamine-Related Disorders -- etiology KW - Microglia -- drug effects KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70785194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Methamphetamine+causes+microglial+activation+in+the+brains+of+human+abusers.&rft.au=Sekine%2C+Yoshimoto%3BOuchi%2C+Yasuomi%3BSugihara%2C+Genichi%3BTakei%2C+Nori%3BYoshikawa%2C+Etsuji%3BNakamura%2C+Kazuhiko%3BIwata%2C+Yasuhide%3BTsuchiya%2C+Kenji+J%3BSuda%2C+Shiro%3BSuzuki%2C+Katsuaki%3BKawai%2C+Masayoshi%3BTakebayashi%2C+Kiyokazu%3BYamamoto%2C+Shigeyuki%3BMatsuzaki%2C+Hideo%3BUeki%2C+Takatoshi%3BMori%2C+Norio%3BGold%2C+Mark+S%3BCadet%2C+Jean+L&rft.aulast=Sekine&rft.aufirst=Yoshimoto&rft.date=2008-05-28&rft.volume=28&rft.issue=22&rft.spage=5756&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.1179-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-01 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2004 Jun;89(6):1445-53 [15189347] Arch Gen Psychiatry. 2004 Jan;61(1):73-84 [14706946] Neurosci Lett. 2004 Sep 9;367(3):349-54 [15337264] J Pharmacol Exp Ther. 2004 Oct;311(1):1-7 [15163680] Brain Res. 1992 Aug 7;587(2):250-6 [1381982] J Pers Soc Psychol. 1992 Sep;63(3):452-9 [1403624] Radiology. 1993 Jan;186(1):59-65 [8416587] J Cereb Blood Flow Metab. 1996 Jan;16(1):42-52 [8530554] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] Nature. 1997 Apr 24;386(6627):827-30 [9126740] Mol Neurobiol. 1997 Dec;15(3):307-39 [9457704] J Immunol. 1998 Feb 15;160(4):1944-8 [9469457] Lancet. 1998 Oct 31;352(9138):1433-7 [9807990] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):868-73 [15644446] Ann Neurol. 2005 Feb;57(2):168-75 [15668962] J Neurochem. 2005 Feb;92(4):790-7 [15686480] Eur Neuropsychopharmacol. 2002 Dec;12(6):581-6 [12468021] Neuroimage. 2003 Jul;19(3):1085-94 [12880834] Am J Psychiatry. 2003 Sep;160(9):1699-701 [12944350] FASEB J. 2003 Oct;17(13):1775-88 [14519657] Neurosci Lett. 2003 Nov 27;352(1):13-6 [14615038] J Neurosci. 1999 Nov 15;19(22):10107-15 [10559418] J Psychoactive Drugs. 2000 Apr-Jun;32(2):137-41 [10908000] Biomed Chromatogr. 2000 Aug;14(5):293-300 [10960827] Brain. 2000 Nov;123 ( Pt 11):2321-37 [11050032] Mol Pharmacol. 2000 Dec;58(6):1247-56 [11093760] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] Exp Neurol. 2001 Jun;169(2):219-30 [11358437] Am J Psychiatry. 2001 Aug;158(8):1206-14 [11481152] Lancet. 2001 Aug 11;358(9280):461-7 [11513911] Neuropsychopharmacology. 2002 Jan;26(1):53-63 [11751032] J Subst Abuse Treat. 2002 Sep;23(2):151-6 [12220613] Glia. 2002 Nov;40(2):206-17 [12379908] Mol Pharmacol. 2002 Nov;62(5):993-1000 [12391261] Exp Neurol. 2004 May;187(1):47-57 [15081587] Neuropsychopharmacology. 2004 May;29(5):1019-26 [15039764] Neuroimage. 2005 Jun;26(2):480-92 [15907305] Brain Res. 2005 Jul 19;1050(1-2):190-8 [15987631] Folia Neuropathol. 2005;43(2):81-9 [16012909] J Pharmacol Exp Ther. 2005 Nov;315(2):658-67 [16076935] Neurotox Res. 2005 Nov;8(3-4):199-206 [16371314] Arch Gen Psychiatry. 2006 Jan;63(1):90-100 [16389202] Eur J Pharmacol. 2006 Aug 21;544(1-3):1-9 [16859675] Biol Psychiatry. 2007 Mar 1;61(5):577-81 [16712806] CNS Neurol Disord Drug Targets. 2007 Jun;6(3):219-33 [17511618] J Neurosci. 2004 Jun 30;24(26):6028-36 [15229250] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.1179-08.2008 ER - TY - CPAPER T1 - Within-Person Differences in Physical Activity Measured by Self-Report and Accelerometer in NHANES 2003-2004 T2 - 55th Annual Meeting on American College of Sports Medicine AN - 40926435; 4851129 JF - 55th Annual Meeting on American College of Sports Medicine AU - Troiano, Richard P AU - Dodd, Kevin W Y1 - 2008/05/28/ PY - 2008 DA - 2008 May 28 KW - Physical activity KW - Accelerometers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40926435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.atitle=Within-Person+Differences+in+Physical+Activity+Measured+by+Self-Report+and+Accelerometer+in+NHANES+2003-2004&rft.au=Troiano%2C+Richard+P%3BDodd%2C+Kevin+W&rft.aulast=Troiano&rft.aufirst=Richard&rft.date=2008-05-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+on+American+College+of+Sports+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={5BED7A1E -083F-4107-A97F-8F8C1C461977}&AKey={EE40F514-DBDD-4E5E-B299-2E312F98 0A6E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis. AN - 70760232; 18348981 AB - The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction pathway that controls cell survival. We previously demonstrated that mice lacking c-Met (Met-KO) in hepatocytes were hypersensitive to Fas-induced liver injury. In this study, we used primary hepatocytes isolated from Met-KO and control (Cre-Ctrl) mice to address more directly the protective effects of c-Met signaling. Loss of c-Met function increased sensitivity to Fas-mediated apoptosis. Hepatocyte growth factor suppressed apoptosis in Cre-Ctrl but not Met-KO hepatocytes concurrently with up-regulation of NF-kappaB and major antiapoptotic proteins Bcl-2 and Bcl-xL. Intriguingly, Met-KO hepatocytes exhibited intrinsic activation of NF-kappaBas well as Bcl-2 and Bcl-xL. Furthermore, unchallenged Met-KO cells displayed oxidative stress as evidenced by overproduction of reactive oxygen species, which was associated with greater NADPH and Rac1 activities, was blocked by the known NADPH oxidase inhibitors, and was paralleled by increased lipid peroxidation and reduced glutathione (GSH) content. N-Acetylcysteine, an antioxidant and GSH precursor, significantly reduced Jo2-induced cell death. Conversely, the GSH-depleting agent buthionine sulfoximine completely abolished the protective effects of N-acetylcysteine in Met-KO hepatocytes. In conclusion, genetic inactivation of c-Met in mouse hepatocytes caused defects in redox regulation, which may account for the increased sensitivity to Fas-induced apoptosis and adaptive up-regulation of NF-kappaB survival signaling. These data provide evidence that intact c-Met signaling is a critical factor in the protection against excessive generation of endogenous reactive oxygen species. JF - The Journal of biological chemistry AU - Gómez-Quiroz, Luis E AU - Factor, Valentina M AU - Kaposi-Novak, Pal AU - Coulouarn, Cedric AU - Conner, Elizabeth A AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA. Y1 - 2008/05/23/ PY - 2008 DA - 2008 May 23 SP - 14581 EP - 14589 VL - 283 IS - 21 SN - 0021-9258, 0021-9258 KW - Antigens, CD95 KW - 0 KW - NF-kappa B KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Proto-Oncogene Proteins c-met KW - EC 2.7.10.1 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Oxidation-Reduction KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Cells, Cultured KW - Oxidative Stress KW - Mice KW - Substrate Specificity KW - Signal Transduction KW - NF-kappa B -- genetics KW - Glutathione -- biosynthesis KW - NF-kappa B -- metabolism KW - Mice, Knockout KW - Proto-Oncogene Proteins c-met -- deficiency KW - Proto-Oncogene Proteins c-met -- genetics KW - Antigens, CD95 -- metabolism KW - Apoptosis KW - Proto-Oncogene Proteins c-met -- metabolism KW - Homeostasis KW - Hepatocytes -- cytology KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70760232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Hepatocyte-specific+c-Met+deletion+disrupts+redox+homeostasis+and+sensitizes+to+Fas-mediated+apoptosis.&rft.au=G%C3%B3mez-Quiroz%2C+Luis+E%3BFactor%2C+Valentina+M%3BKaposi-Novak%2C+Pal%3BCoulouarn%2C+Cedric%3BConner%2C+Elizabeth+A%3BThorgeirsson%2C+Snorri+S&rft.aulast=G%C3%B3mez-Quiroz&rft.aufirst=Luis&rft.date=2008-05-23&rft.volume=283&rft.issue=21&rft.spage=14581&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M707733200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-18 N1 - Date created - 2008-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1993 Aug 26;364(6440):806-9 [7689176] Methods Enzymol. 1987;143:101-9 [3657520] Nature. 1995 Feb 23;373(6516):702-5 [7854453] Biochem Biophys Res Commun. 1996 May 6;222(1):64-70 [8630075] Mutat Res. 1996 Aug 8;360(3):181-6 [8692217] J Biochem. 1996 Apr;119(4):591-600 [8743556] Semin Liver Dis. 1998;18(4):415-24 [9875558] Annu Rev Pharmacol Toxicol. 1999;39:67-101 [10331077] Cell Res. 2005 Jan;15(1):49-51 [15686627] Circ Res. 2005 Feb 18;96(3):300-7 [15637298] Oncogene. 2005 Mar 3;24(10):1749-66 [15688034] Toxicol Appl Pharmacol. 2005 May 1;204(3):263-73 [15845418] J Biol Chem. 2005 Jul 22;280(29):27179-94 [15917250] Free Radic Res. 2005 Oct;39(10):1127-38 [16298738] Gastroenterology. 2005 Dec;129(6):2009-31 [16344068] J Biol Chem. 2006 Jan 6;281(1):221-8 [16234234] J Cell Physiol. 2006 May;207(2):322-30 [16331683] J Clin Invest. 2006 Jun;116(6):1582-95 [16710476] J Biol Chem. 2006 Jun 30;281(26):17718-26 [16636067] Cell. 2006 Oct 20;127(2):397-408 [17055439] Biochem Pharmacol. 2006 Nov 30;72(11):1493-505 [16723122] J Mol Endocrinol. 2007 Feb;38(1-2):147-58 [17242177] Hepatology. 2007 May;45(5):1210-7 [17464994] Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11412-7 [17595299] Cancer Res. 2007 Oct 15;67(20):9844-51 [17942915] J Biochem. 1999 Nov;126(5):815-20 [10544272] Free Radic Biol Med. 1999 Nov;27(9-10):1019-26 [10569634] Am J Pathol. 2001 Jan;158(1):275-80 [11141501] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):247-52 [11134526] Nat Cell Biol. 2001 Jul;3(7):E161-2 [11433311] Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1357-68 [11705740] Mol Cell Biol. 2002 Feb;22(4):1060-72 [11809798] Mol Cell. 2002 Feb;9(2):411-21 [11864613] Cell Death Differ. 2003 Jan;10(1):26-35 [12655293] Cell Death Differ. 2003 May;10(5):508-15 [12728249] Free Radic Biol Med. 2003 Sep 15;35(6):648-61 [12957657] J Clin Invest. 2003 Oct;112(7):989-98 [14523036] Free Radic Biol Med. 2004 Jan 1;36(1):16-26 [14732287] Hepatology. 2004 Mar;39(3):645-54 [14999683] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4477-82 [15070743] Free Radic Biol Med. 2004 Jul 15;37(2):166-75 [15203188] Apoptosis. 2004 Sep;9(5):515-23 [15314279] Hepatology. 2004 Sep;40(3):590-9 [15349897] Hepatology. 2004 Aug;40(2):403-13 [15368445] Methods Enzymol. 1978;52:302-10 [672633] Nature. 1995 Feb 23;373(6516):699-702 [7854452] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M707733200 ER - TY - JOUR T1 - N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo. AN - 71639345; 18498627 AB - During the early and mid part of 20th century, several reports described the therapeutic effects of N-methylisatin-beta-Thiosemicarbazone (MIBT) against pox viruses, Maloney leukemia viruses and recently against HIV. However, their ability to inhibit flavivirus replication has not been investigated. Hence the present study was designed to evaluate the antiviral activity of 14 MIBT derivatives against Flaviviruses that are prevalent in India such as Japanese Encephalitis Virus (JEV), Dengue-2 (Den-2) and West Nile viruses (WNV). Amongst the fourteen Mannich bases of MIBT derivatives tested one compound - SCH 16 was able to completely inhibit in vitro Japanese encephalitis virus (JEV) and West Nile virus (WNV) replication. However no antiviral activity of SCH 16 was noted against Den-2 virus replication. This compound was able to inhibit 50% of the plaques (IC50) produced by JEV and WNV at a concentration of 16 microgm/ml (0.000025 microM) and 4 microgm/ml (0.000006 microM) respectively. Furthermore, SCH 16 at a concentration of 500 mg/kg body weight administered by oral route twice daily was able to completely (100%) prevent mortality in mice challenged with 50LD50 JEV by the peripheral route. Our experiments to understand the mechanism of action suggest that SCH 16 inhibited JEV replication at the level of early protein translation. Only one of the 14 isatin derivatives -SCH 16 exhibited antiviral action on JEV and WNV virus infection in vitro. SCH 16 was also found to completely inhibit JEV replication in vivo in a mouse model challenged peripherally with 50LD50 of the virus. These results warrant further research and development on SCH 16 as a possible therapeutic agent. JF - Virology journal AU - Sebastian, Liba AU - Desai, Anita AU - Shampur, Madhusudana N AU - Perumal, Yogeeswari AU - Sriram, D AU - Vasanthapuram, Ravi AD - Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore-560029, India. liba_sebastian@yahoo.co.in Y1 - 2008/05/22/ PY - 2008 DA - 2008 May 22 SP - 64 VL - 5 KW - Antiviral Agents KW - 0 KW - Thiosemicarbazones KW - Index Medicus KW - Swine KW - Models, Animal KW - Protein Biosynthesis -- drug effects KW - Animals KW - Virus Replication -- drug effects KW - Kinetics KW - Mice KW - Inhibitory Concentration 50 KW - Drug Evaluation, Preclinical KW - Cytopathogenic Effect, Viral -- drug effects KW - Cell Line KW - Cricetinae KW - Encephalitis, Japanese -- virology KW - Antiviral Agents -- pharmacology KW - Antiviral Agents -- chemistry KW - Encephalitis, Japanese -- drug therapy KW - Encephalitis Virus, Japanese -- physiology KW - Encephalitis Virus, Japanese -- drug effects KW - Thiosemicarbazones -- pharmacology KW - Thiosemicarbazones -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71639345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology+journal&rft.atitle=N-methylisatin-beta-thiosemicarbazone+derivative+%28SCH+16%29+is+an+inhibitor+of+Japanese+encephalitis+virus+infection+in+vitro+and+in+vivo.&rft.au=Sebastian%2C+Liba%3BDesai%2C+Anita%3BShampur%2C+Madhusudana+N%3BPerumal%2C+Yogeeswari%3BSriram%2C+D%3BVasanthapuram%2C+Ravi&rft.aulast=Sebastian&rft.aufirst=Liba&rft.date=2008-05-22&rft.volume=5&rft.issue=&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Virology+journal&rft.issn=1743-422X&rft_id=info:doi/10.1186%2F1743-422X-5-64 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-03 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Indian J Exp Biol. 1991 Jan;29(1):1-5 [1864613] J Neurol Sci. 1994 Mar;122(1):109-16 [7515105] Antiviral Res. 1994 Aug;24(4):305-14 [7993075] J Vet Diagn Invest. 1995 Apr;7(2):173-6 [7619897] Antimicrob Agents Chemother. 1997 May;41(5):965-71 [9145853] Chemotherapy. 1999 May-Jun;45(3):192-6 [10224341] Curr Opin Investig Drugs. 2002 Nov;3(11):1567-73 [12476954] J Gen Virol. 2002 Aug;83(Pt 8):1897-905 [12124453] EMBO J. 2002 Jun 3;21(11):2757-68 [12032088] J Virol. 2002 Apr;76(8):3596-604 [11907199] Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7981-6 [10869440] Recent Pat Antiinfect Drug Discov. 2006 Jan;1(1):45-55 [18221133] Pharmazie. 2006 Apr;61(4):274-7 [16649536] J Virol. 2006 Mar;80(6):2976-86 [16501107] J Pharm Pharm Sci. 2005;8(3):565-77 [16401403] Bioorg Med Chem Lett. 2005 Oct 15;15(20):4451-5 [16115762] Virol J. 2005;2:53 [15985182] J Virol. 2005 Jul;79(14):8698-706 [15994763] J Virol. 2005 Feb;79(3):1943-7 [15650220] Bioorg Med Chem. 2005 Jan 3;13(1):257-64 [15582469] Mol Cell Biol. 1999 Jul;19(7):4653-63 [10373514] Br J Pharmacol Chemother. 1960 Mar;15:101-10 [13797622] Antimicrob Agents Chemother. 1987 Nov;31(11):1798-802 [3501701] Antiviral Res. 1985 Aug;5(4):249-54 [2412491] Virology. 1979 Jul 30;96(2):381-92 [462812] J Gen Virol. 1975 Sep;28(3):271-83 [809544] Nat New Biol. 1971 Jul 28;232(30):116-8 [4328024] Proc Natl Acad Sci U S A. 1965 Sep;54(3):946-53 [5217472] Ann N Y Acad Sci. 1965 Jul 30;130(1):110-7 [5323377] Nat Rev Microbiol. 2003 Dec;1(3):181-90 [15035022] Bioorg Med Chem Lett. 2004 Mar 8;14(5):1085-7 [14980640] J Virol. 2004 Feb;78(3):1344-51 [14722289] Virology. 2003 Dec 20;317(2):275-90 [14698666] Neurotoxicology. 2004 Jan;25(1-2):205-13 [14697895] Antiviral Res. 2004 Feb;61(2):111-7 [14670584] Antiviral Res. 2003 Mar;58(1):73-9 [12719009] J Clin Microbiol. 2003 Jun;41(6):2408-16 [12791857] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15125-30 [14645707] J Neurol Sci. 2003 Jan 15;206(1):79-83 [12480089] Virology. 2002 Dec 20;304(2):211-21 [12504563] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-422X-5-64 ER - TY - JOUR T1 - On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. AN - 70727666; 18442228 AB - The publication of the crystal structure of the beta2-adrenergic receptor (beta2-AR) proved that G protein-coupled receptors (GPCRs) share a structurally conserved rhodopsin-like 7TM core. Here, to probe to which extent realistic GPCR structures can be recreated through modeling, carazolol was docked at two rhodopsin-based homology models of the human beta 2-AR. The first featured a rhodopsin-like second extracellular loop, which interfered with ligand docking and with the orientation of several residues in the binding pocket. The second featured a second extracellular loop built completely de novo, which afforded a more accurate model of the binding pocket and a better docking of the ligand. Furthermore, incorporating available biochemical and computational data to the model by correcting the conformation of a single residue lining the binding pocket --Phe290(6.52)--, resulted in significantly improved docking poses. These results support the applicability of GPCR modeling to the design of site-directed mutagenesis experiments and to drug discovery. JF - Journal of medicinal chemistry AU - Costanzi, Stefano AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. stefanoc@mail.nih.gov Y1 - 2008/05/22/ PY - 2008 DA - 2008 May 22 SP - 2907 EP - 2914 VL - 51 IS - 10 SN - 0022-2623, 0022-2623 KW - Propanolamines KW - 0 KW - Receptors, Adrenergic, beta-2 KW - carazolol KW - 29PW75S82A KW - Rhodopsin KW - 9009-81-8 KW - Index Medicus KW - Humans KW - Crystallography, X-Ray KW - Sequence Homology, Amino Acid KW - Rhodopsin -- chemistry KW - Drug Design KW - Protein Conformation KW - Propanolamines -- chemistry KW - Binding Sites KW - Receptors, Adrenergic, beta-2 -- chemistry KW - Models, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70727666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=On+the+applicability+of+GPCR+homology+models+to+computer-aided+drug+discovery%3A+a+comparison+between+in+silico+and+crystal+structures+of+the+beta2-adrenergic+receptor.&rft.au=Costanzi%2C+Stefano&rft.aulast=Costanzi&rft.aufirst=Stefano&rft.date=2008-05-22&rft.volume=51&rft.issue=10&rft.spage=2907&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm800044k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-09 N1 - Date created - 2008-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2000 Aug 4;289(5480):739-45 [10926528] J Med Chem. 2007 Jun 28;50(13):2981-9 [17552505] Mol Pharmacol. 2001 Jul;60(1):1-19 [11408595] J Med Chem. 2001 Sep 13;44(19):3092-108 [11543678] J Med Chem. 2001 Nov 22;44(24):4125-36 [11708915] Chembiochem. 2002 Oct 4;3(10):928-44 [12362358] J Biol Chem. 2002 Oct 25;277(43):40989-96 [12167654] Angew Chem Int Ed Engl. 2004 Jan;43(2):248-51 [14695622] J Biol Chem. 2004 Jan 2;279(1):686-91 [14559905] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2736-41 [14981238] J Chem Inf Comput Sci. 2004 May-Jun;44(3):1162-76 [15154786] EMBO J. 2004 Sep 15;23(18):3609-20 [15329674] J Med Chem. 2004 Oct 21;47(22):5393-404 [15481977] J Mol Biol. 2004 Nov 5;343(5):1409-38 [15491621] Mol Pharmacol. 2004 Nov;66(5):1192-200 [15306657] Nature. 1986 May 1-7;321(6065):75-9 [3010132] J Biol Chem. 1987 Oct 15;262(29):14282-8 [2821000] EMBO J. 1993 Apr;12(4):1693-703 [8385611] Nature. 1993 Apr 22;362(6422):770-2 [8469290] J Mol Biol. 1993 Dec 5;234(3):779-815 [8254673] J Biol Chem. 1994 Mar 4;269(9):6743-52 [8120034] J Biol Chem. 1994 Oct 7;269(40):24692-8 [7929142] Annu Rev Biochem. 1994;63:101-32 [7979235] Protein Sci. 1994 Sep;3(9):1582-96 [7833817] J Biol Chem. 1995 Jun 9;270(23):13987-97 [7775460] Mol Pharmacol. 1996 Apr;49(4):683-91 [8609897] Biochemistry. 1998 Jan 27;37(4):998-1006 [9454590] Biochemistry. 1999 Mar 23;38(12):3498-507 [10090736] Br J Pharmacol. 1999 Sep;128(2):272-4 [10510435] Mol Interv. 2004 Dec;4(6):337-47 [15616163] Trends Pharmacol Sci. 2005 Jan;26(1):44-51 [15629204] J Med Chem. 2005 Jan 13;48(1):152-62 [15634009] Biochemistry. 2005 Feb 22;44(7):2419-31 [15709754] J Med Chem. 2005 Feb 24;48(4):1088-97 [15715476] Proteins. 2005 Dec 1;61(4):938-52 [16224780] J Med Chem. 2005 Dec 29;48(26):8108-11 [16366591] J Med Chem. 2007 Jul 12;50(14):3229-41 [17564423] Nat Methods. 2007 Nov;4(11):927-9 [17952087] Nature. 2007 Nov 15;450(7168):383-7 [17952055] Science. 2007 Nov 23;318(5854):1266-73 [17962519] Science. 2007 Nov 23;318(5854):1258-65 [17962520] J Med Chem. 2006 Mar 9;49(5):1706-19 [16509586] Curr Med Chem. 2006;13(14):1667-91 [16787212] Curr Pharm Des. 2006;12(17):2175-85 [16796562] Nat Chem Biol. 2006 Aug;2(8):417-22 [16799554] J Mol Graph Model. 2006 Sep;25(1):10-6 [16303324] J Comput Aided Mol Des. 2006 Jul-Aug;20(7-8):417-26 [17016747] J Biol Chem. 2007 Jan 5;282(1):518-25 [17079233] J Med Chem. 2007 Mar 22;50(6):1294-303 [17311371] Curr Top Med Chem. 2007;7(10):991-8 [17508932] Endocrinology. 2001 Jan;142(1):2-10 [11145559] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800044k ER - TY - CPAPER T1 - CpG Oligonucleotides Enhance Proliferative and Effector Responses of B Cells in HIV-Infected Individuals T2 - Third International Conference on Immunopotentiators in Modern Vaccines (IMV 2008) AN - 40966179; 4869290 JF - Third International Conference on Immunopotentiators in Modern Vaccines (IMV 2008) AU - Malaspina, Angela Y1 - 2008/05/21/ PY - 2008 DA - 2008 May 21 KW - Lymphocytes B KW - Oligonucleotides KW - CpG islands KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40966179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+Immunopotentiators+in+Modern+Vaccines+%28IMV+2008%29&rft.atitle=CpG+Oligonucleotides+Enhance+Proliferative+and+Effector+Responses+of+B+Cells+in+HIV-Infected+Individuals&rft.au=Malaspina%2C+Angela&rft.aulast=Malaspina&rft.aufirst=Angela&rft.date=2008-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+Immunopotentiators+in+Modern+Vaccines+%28IMV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/imv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Phase 1 Study of the Blood-Stage Malaria Vaccine Candidate AMA1-c1/Alhydrogel with CPG 7909, Using Two different CPG 7909 Formulations and Dosing Intervals T2 - Third International Conference on Immunopotentiators in Modern Vaccines (IMV 2008) AN - 40961376; 4869292 JF - Third International Conference on Immunopotentiators in Modern Vaccines (IMV 2008) AU - Ellis, Ruth D Y1 - 2008/05/21/ PY - 2008 DA - 2008 May 21 KW - Vaccines KW - Malaria KW - CpG islands KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40961376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+Immunopotentiators+in+Modern+Vaccines+%28IMV+2008%29&rft.atitle=A+Phase+1+Study+of+the+Blood-Stage+Malaria+Vaccine+Candidate+AMA1-c1%2FAlhydrogel+with+CPG+7909%2C+Using+Two+different+CPG+7909+Formulations+and+Dosing+Intervals&rft.au=Ellis%2C+Ruth+D&rft.aulast=Ellis&rft.aufirst=Ruth&rft.date=2008-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+Immunopotentiators+in+Modern+Vaccines+%28IMV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/imv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Yellow Lasers for Flow Cytometry: Current Progress T2 - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AN - 40982283; 4870853 JF - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AU - Telford, William G AU - Kapoor, Veena AU - Karpov, Vladimir AU - Linton, Claudette AU - Subach, Fedor V AU - Verkhusha, Vladislav V Y1 - 2008/05/17/ PY - 2008 DA - 2008 May 17 KW - Lasers KW - Flow cytometry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40982283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.atitle=Yellow+Lasers+for+Flow+Cytometry%3A+Current+Progress&rft.au=Telford%2C+William+G%3BKapoor%2C+Veena%3BKarpov%2C+Vladimir%3BLinton%2C+Claudette%3BSubach%2C+Fedor+V%3BVerkhusha%2C+Vladislav+V&rft.aulast=Telford&rft.aufirst=William&rft.date=2008-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isac-net.org/congress2008/documents/colorbars_isac_program. pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preliminary Study for the Identification and Characterization of Tumour Initiating Cells in Lung Cancer T2 - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AN - 40979269; 4871068 JF - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AU - Pirozzi, Giuseppe AU - Tirino, Virginia AU - Rocco, Antonello AU - Camerlingo, Rosa AU - Marzocchella, Caterina AU - Franco, Renato AU - Viglietto, Giuseppe AU - Rocco, Gaetano Y1 - 2008/05/17/ PY - 2008 DA - 2008 May 17 KW - Lung cancer KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40979269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.atitle=Preliminary+Study+for+the+Identification+and+Characterization+of+Tumour+Initiating+Cells+in+Lung+Cancer&rft.au=Pirozzi%2C+Giuseppe%3BTirino%2C+Virginia%3BRocco%2C+Antonello%3BCamerlingo%2C+Rosa%3BMarzocchella%2C+Caterina%3BFranco%2C+Renato%3BViglietto%2C+Giuseppe%3BRocco%2C+Gaetano&rft.aulast=Pirozzi&rft.aufirst=Giuseppe&rft.date=2008-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isac-net.org/congress2008/documents/colorbars_isac_program. pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Supercontinuum White Light Lasers for Flow Cytometry T2 - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AN - 40978788; 4870852 JF - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AU - Telford, William G AU - Kapoor, Veena AU - Grudinin, Anatoly AU - Kozlov, Vladimir AU - Imam, Husain AU - Subach, Fedor V AU - Verkhusha, Vladislav V Y1 - 2008/05/17/ PY - 2008 DA - 2008 May 17 KW - Lasers KW - Flow cytometry KW - Light effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40978788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.atitle=Supercontinuum+White+Light+Lasers+for+Flow+Cytometry&rft.au=Telford%2C+William+G%3BKapoor%2C+Veena%3BGrudinin%2C+Anatoly%3BKozlov%2C+Vladimir%3BImam%2C+Husain%3BSubach%2C+Fedor+V%3BVerkhusha%2C+Vladislav+V&rft.aulast=Telford&rft.aufirst=William&rft.date=2008-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isac-net.org/congress2008/documents/colorbars_isac_program. pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Approaches for Combined Cell Volume and Multiparameter Flow Cytometric Analysis during Lymphocyte Apoptosis T2 - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AN - 40968014; 4871197 JF - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AU - Bortner, Carl D AU - Sifre, Maria I AU - Cidlowski, John A Y1 - 2008/05/17/ PY - 2008 DA - 2008 May 17 KW - Lymphocytes KW - Flow cytometry KW - Cell size KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40968014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.atitle=New+Approaches+for+Combined+Cell+Volume+and+Multiparameter+Flow+Cytometric+Analysis+during+Lymphocyte+Apoptosis&rft.au=Bortner%2C+Carl+D%3BSifre%2C+Maria+I%3BCidlowski%2C+John+A&rft.aulast=Bortner&rft.aufirst=Carl&rft.date=2008-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isac-net.org/congress2008/documents/colorbars_isac_program. pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiscale Techniques for Segmenting Interphase Nuclei from 2-D Fluorescence Images T2 - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AN - 40967218; 4870864 JF - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AU - Gudla, Prabhakar R AU - Collins, J AU - Nandy, K AU - Meaburn, K J AU - Misteli, T AU - Lockett, S J Y1 - 2008/05/17/ PY - 2008 DA - 2008 May 17 KW - Fluorescence KW - Nuclei KW - Interphase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40967218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.atitle=Multiscale+Techniques+for+Segmenting+Interphase+Nuclei+from+2-D+Fluorescence+Images&rft.au=Gudla%2C+Prabhakar+R%3BCollins%2C+J%3BNandy%2C+K%3BMeaburn%2C+K+J%3BMisteli%2C+T%3BLockett%2C+S+J&rft.aulast=Gudla&rft.aufirst=Prabhakar&rft.date=2008-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isac-net.org/congress2008/documents/colorbars_isac_program. pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polychromatic Flow Cytometry: Instrument Monitoring and Data Validation T2 - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AN - 40965914; 4871193 JF - XXIV International Congress of the International Society for Analytical Cytology (ISAC 2008) AU - Perfetto, Stephen P AU - Nguyen, Richard AU - Ambrozak, David AU - Roederer, Mario Y1 - 2008/05/17/ PY - 2008 DA - 2008 May 17 KW - Monitoring instruments KW - Flow cytometry KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40965914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.atitle=Polychromatic+Flow+Cytometry%3A+Instrument+Monitoring+and+Data+Validation&rft.au=Perfetto%2C+Stephen+P%3BNguyen%2C+Richard%3BAmbrozak%2C+David%3BRoederer%2C+Mario&rft.aulast=Perfetto&rft.aufirst=Stephen&rft.date=2008-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIV+International+Congress+of+the+International+Society+for+Analytical+Cytology+%28ISAC+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isac-net.org/congress2008/documents/colorbars_isac_program. pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specialization in Medical Librarianship T2 - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AN - 40987284; 4878502 JF - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AU - Livinski, Alicia A AU - Crummett, Courtney D Y1 - 2008/05/16/ PY - 2008 DA - 2008 May 16 KW - Specialization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40987284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.atitle=Specialization+in+Medical+Librarianship&rft.au=Livinski%2C+Alicia+A%3BCrummett%2C+Courtney+D&rft.aulast=Livinski&rft.aufirst=Alicia&rft.date=2008-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={487243E2 -7B8F-43D7-99CB-40270128B768}&AKey={B4B59EC6-3192-4606-B61F-443AD7BE ABC9} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are We Making a Difference? Citations to Articles Published in ORL-Head and Neck Nursing T2 - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AN - 40982288; 4878424 JF - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AU - Livinski, Alicia A AU - Sieving, Pamela C AU - Rudy, Susan F Y1 - 2008/05/16/ PY - 2008 DA - 2008 May 16 KW - Neck KW - Nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40982288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.atitle=Are+We+Making+a+Difference%3F+Citations+to+Articles+Published+in+ORL-Head+and+Neck+Nursing&rft.au=Livinski%2C+Alicia+A%3BSieving%2C+Pamela+C%3BRudy%2C+Susan+F&rft.aulast=Livinski&rft.aufirst=Alicia&rft.date=2008-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={487243E2 -7B8F-43D7-99CB-40270128B768}&AKey={B4B59EC6-3192-4606-B61F-443AD7BE ABC9} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are We Meeting Our Customers Needs? Evaluation of Information Desk Services and Staffing T2 - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AN - 40981597; 4878453 DE: JF - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AU - Livinski, Alicia A AU - Brown, Brian Y1 - 2008/05/16/ PY - 2008 DA - 2008 May 16 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40981597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.atitle=Are+We+Meeting+Our+Customers+Needs%3F+Evaluation+of+Information+Desk+Services+and+Staffing&rft.au=Livinski%2C+Alicia+A%3BBrown%2C+Brian&rft.aulast=Livinski&rft.aufirst=Alicia&rft.date=2008-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={487243E2 -7B8F-43D7-99CB-40270128B768}&AKey={B4B59EC6-3192-4606-B61F-443AD7BE ABC9} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are they Benefiting? Developing Country Authors Research Productivity in the Tropical Diseases Literature T2 - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AN - 40977680; 4878460 JF - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AU - Livinski, Alicia Y1 - 2008/05/16/ PY - 2008 DA - 2008 May 16 KW - Developing countries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40977680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.atitle=Are+they+Benefiting%3F+Developing+Country+Authors+Research+Productivity+in+the+Tropical+Diseases+Literature&rft.au=Livinski%2C+Alicia&rft.aulast=Livinski&rft.aufirst=Alicia&rft.date=2008-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={487243E2 -7B8F-43D7-99CB-40270128B768}&AKey={B4B59EC6-3192-4606-B61F-443AD7BE ABC9} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Making a Commitment to Evidence-based Library and Information Practice: The Role of Library Leadership T2 - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AN - 40976480; 4878471 JF - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AU - Whitmore, Susan C Y1 - 2008/05/16/ PY - 2008 DA - 2008 May 16 KW - Lead UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40976480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.atitle=Making+a+Commitment+to+Evidence-based+Library+and+Information+Practice%3A+The+Role+of+Library+Leadership&rft.au=Whitmore%2C+Susan+C&rft.aulast=Whitmore&rft.aufirst=Susan&rft.date=2008-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={487243E2 -7B8F-43D7-99CB-40270128B768}&AKey={B4B59EC6-3192-4606-B61F-443AD7BE ABC9} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Opening Doors: Contemporary African American Surgeons T2 - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AN - 40975560; 4878480 JF - 2008 Annual Meeting and Exhibition of the Medical Library Association (MLA 2008) AU - Newmark, Jill AU - Hutto, Margaret Y1 - 2008/05/16/ PY - 2008 DA - 2008 May 16 KW - Africa KW - Medical personnel KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40975560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.atitle=Opening+Doors%3A+Contemporary+African+American+Surgeons&rft.au=Newmark%2C+Jill%3BHutto%2C+Margaret&rft.aulast=Newmark&rft.aufirst=Jill&rft.date=2008-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+and+Exhibition+of+the+Medical+Library+Association+%28MLA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={487243E2 -7B8F-43D7-99CB-40270128B768}&AKey={B4B59EC6-3192-4606-B61F-443AD7BE ABC9} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Susceptibility genes in movement disorders. AN - 742775525; pmid-18311830 AB - During the last years, remarkable progress in our understanding of molecular genetic mechanisms underlying movement disorders has been achieved. The successes of linkage studies, followed by positional cloning, have dominated the last decade and several genes underlying monogenic disorders have been discovered. The pathobiological understanding garnered from these mutations has laid the foundation for much of the search for genetic loci that confer risk for, rather than cause, disease. With the introduction of whole genome association studies as a novel tool to investigate genetic variation underlying common, complex diseases, a new era in neurogenomics has just begun. As the field rapidly moves forward several new challenges and critical questions in clinical care have to be addressed. In this review, we summarize recent advances in the discovery of susceptibility loci underlying major movement disorders, explain the newest methodologies and tools employed for finding and characterizing genes and discuss how insights into the molecular genetic basis of neurological disorders will impact therapeutic concepts in patient care. JF - Movement disorders : official journal of the Movement Disorder Society AU - Scholz, Sonja AU - Singleton, Andrew AD - Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/05/15/ PY - 2008 DA - 2008 May 15 SP - 927 EP - 34; quiz 1064 VL - 23 IS - 7 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Point Mutation -- genetics KW - Genotype KW - Phenotype KW - Molecular Chaperones -- genetics KW - Alleles KW - Genomics -- methods KW - Humans KW - Linkage (Genetics) -- genetics KW - Chromosome Aberrations KW - Genetic Predisposition to Disease KW - Movement Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742775525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Susceptibility+genes+in+movement+disorders.&rft.au=Scholz%2C+Sonja%3BSingleton%2C+Andrew&rft.aulast=Scholz&rft.aufirst=Sonja&rft.date=2008-05-15&rft.volume=23&rft.issue=7&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma. AN - 70735764; 18483372 AB - Poxviral vectors have a proven safety record and can be used to incorporate multiple transgenes. Prior clinical trials with poxviral vaccines have shown that immunologic tolerance to self-antigens can be broken. Carcinoembryonic antigen (CEA) and MUC-1 are overexpressed in a substantial proportion of common solid carcinomas. The primary end point of this study was vaccine safety, with immunologic and clinical responses as secondary end points. We report here a pilot study of 25 patients treated with a poxviral vaccine regimen consisting of the genes for CEA and MUC-1, along with a triad of costimulatory molecules (TRICOM; composed of B7.1, intercellular adhesion molecule 1, and lymphocyte function-associated antigen 3) engineered into vaccinia (PANVAC-V) as a prime vaccination and into fowlpox (PANVAC-F) as a booster vaccination. The vaccine was well tolerated. Apart from injection-site reaction, no grade > or =2 toxicity was seen in more than 2% of the cycles. Immune responses to MUC-1 and/or CEA were seen following vaccination in 9 of 16 patients tested. A patient with clear cell ovarian cancer and symptomatic ascites had a durable (18-month) clinical response radiographically and biochemically, and one breast cancer patient had a confirmed decrease of >20% in the size of large liver metastasis. This vaccine strategy seems to be safe, is associated with both CD8 and CD4 immune responses, and has shown evidence of clinical activity. Further trials with this agent, either alone or in combination with immunopotentiating and other therapeutic agents, are warranted. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Gulley, James L AU - Arlen, Philip M AU - Tsang, Kwong-Yok AU - Yokokawa, Junko AU - Palena, Claudia AU - Poole, Diane J AU - Remondo, Cinzia AU - Cereda, Vittore AU - Jones, Jacquin L AU - Pazdur, Mary P AU - Higgins, Jack P AU - Hodge, James W AU - Steinberg, Seth M AU - Kotz, Herbert AU - Dahut, William L AU - Schlom, Jeffrey AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2008/05/15/ PY - 2008 DA - 2008 May 15 SP - 3060 EP - 3069 VL - 14 IS - 10 SN - 1078-0432, 1078-0432 KW - Adjuvants, Immunologic KW - 0 KW - Antigens, CD58 KW - Antigens, CD80 KW - Cancer Vaccines KW - Carcinoembryonic Antigen KW - MUC1 protein, human KW - Mucin-1 KW - Vaccines, Synthetic KW - Intercellular Adhesion Molecule-1 KW - 126547-89-5 KW - Index Medicus KW - Intercellular Adhesion Molecule-1 -- therapeutic use KW - Intercellular Adhesion Molecule-1 -- immunology KW - Humans KW - Aged KW - Pilot Projects KW - Vaccines, Synthetic -- therapeutic use KW - Adjuvants, Immunologic -- metabolism KW - Antigens, CD58 -- immunology KW - Antigens, CD80 -- immunology KW - Genetic Vectors KW - Vaccines, Synthetic -- immunology KW - Adult KW - Middle Aged KW - Antigens, CD80 -- therapeutic use KW - Antigens, CD58 -- therapeutic use KW - Male KW - Adjuvants, Immunologic -- therapeutic use KW - Female KW - Mucin-1 -- therapeutic use KW - Cancer Vaccines -- immunology KW - Carcinoembryonic Antigen -- immunology KW - Mucin-1 -- immunology KW - Cancer Vaccines -- therapeutic use KW - Carcinoembryonic Antigen -- therapeutic use KW - Neoplasms -- therapy KW - Poxviridae -- immunology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70735764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Pilot+study+of+vaccination+with+recombinant+CEA-MUC-1-TRICOM+poxviral-based+vaccines+in+patients+with+metastatic+carcinoma.&rft.au=Gulley%2C+James+L%3BArlen%2C+Philip+M%3BTsang%2C+Kwong-Yok%3BYokokawa%2C+Junko%3BPalena%2C+Claudia%3BPoole%2C+Diane+J%3BRemondo%2C+Cinzia%3BCereda%2C+Vittore%3BJones%2C+Jacquin+L%3BPazdur%2C+Mary+P%3BHiggins%2C+Jack+P%3BHodge%2C+James+W%3BSteinberg%2C+Seth+M%3BKotz%2C+Herbert%3BDahut%2C+William+L%3BSchlom%2C+Jeffrey&rft.aulast=Gulley&rft.aufirst=James&rft.date=2008-05-15&rft.volume=14&rft.issue=10&rft.spage=3060&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-0126 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-18 N1 - Date created - 2008-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Nov 15;59(22):5800-7 [10582702] Cancer Res. 2004 Nov 1;64(21):7985-94 [15520206] Cancer Immunol Immunother. 2006 Jan;55(1):63-7 [15864588] J Exp Med. 2005 Dec 19;202(12):1691-701 [16365148] Cancer Immunol Immunother. 2005 Mar;54(3):254-64 [15372205] J Clin Oncol. 2005 Feb 1;23(4):720-31 [15613691] Blood. 2005 Apr 1;105(7):2862-8 [15591121] J Immunol. 2005 May 15;174(10):5994-6004 [15879092] Clin Cancer Res. 2005 Jun 15;11(12):4430-6 [15958627] Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):869-77 [16467101] Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):878-87 [16467102] Clin Cancer Res. 2006 Feb 15;12(4):1260-9 [16489082] J Exp Med. 2006 May 15;203(5):1259-71 [16636135] J Clin Oncol. 2006 Jul 1;24(19):3089-94 [16809734] Expert Opin Investig Drugs. 2006 Nov;15(11):1395-410 [17040199] Expert Opin Biol Ther. 2007 Apr;7(4):543-54 [17373905] Vaccine. 2007 Sep 27;25 Suppl 2:B89-96 [17573164] Int J Cancer. 2000 Mar 15;85(6):829-38 [10709104] Surgery. 2000 Apr;127(4):383-9 [10776428] J Natl Cancer Inst. 2000 Aug 2;92(15):1228-39 [10922408] J Clin Oncol. 2000 Dec 1;18(23):3964-73 [11099326] Cancer Immunol Immunother. 2000 Dec;49(10):517-29 [11129322] Cancer Res. 2001 Jan 1;61(1):206-14 [11196163] Cancer Res. 2001 May 1;61(9):3689-97 [11325840] Clin Cancer Res. 2001 May;7(5):1181-91 [11350882] Cancer Res. 2001 Jun 1;61(11):4497-505 [11389081] Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8809-14 [11427731] J Immunother. 2002 Mar-Apr;25(2):97-138 [12074049] Prostate. 2002 Oct 1;53(2):109-17 [12242725] Clin Cancer Res. 2002 Oct;8(10):3219-25 [12374692] J Clin Oncol. 2003 Apr 1;21(7):1232-7 [12663709] Clin Cancer Res. 2003 May;9(5):1837-49 [12738742] J Clin Oncol. 2003 May 15;21(10 Suppl):187s-193s [12743133] J Immunol. 2003 Jun 15;170(12):6338-47 [12794167] Br J Radiol. 2004 Jan;77(913):74-5 [14988145] J Natl Cancer Inst. 2004 Mar 17;96(6):487-8 [15026475] Clin Cancer Res. 2004 Mar 15;10(6):2139-49 [15041735] J Immunother. 2004 May-Jun;27(3):240-53 [15076142] J Clin Oncol. 2004 Jun 1;22(11):2122-32 [15169798] J Immunol. 1987 Aug 15;139(4):1113-9 [3038997] Cancer Res. 1991 Jul 15;51(14):3657-62 [1712245] Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3539-43 [8097319] J Exp Med. 1994 Apr 1;179(4):1109-18 [8145033] J Natl Cancer Inst. 1995 Jul 5;87(13):982-90 [7629885] J Clin Oncol. 1996 May;14(5):1545-51 [8622070] Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10972-7 [8855293] Vaccine. 1997 Apr-May;15(6-7):759-68 [9178479] Cancer Res. 1997 Oct 15;57(20):4570-7 [9377571] J Immunol. 1998 Apr 1;160(7):3363-73 [9531296] J Clin Oncol. 1998 Jul;16(7):2401-8 [9667257] BMC Immunol. 2005;6:17 [16026627] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-0126 ER - TY - JOUR T1 - Simultaneous NMR study of protein structure and dynamics using conservative mutagenesis. AN - 69187259; 18358021 AB - A novel iterative procedure is described that allows both the orientation and dynamics of internuclear bond vectors to be determined from direct interpretation of NMR dipolar couplings, measured under at least three orthogonal alignment conditions. If five orthogonal alignments are available, the approach also yields information on the degree of motional anisotropy and the direction in which the largest amplitude internal motion of each bond vector takes place. The method is demonstrated for the backbone (15)N-(1)H, (13)C(alpha)-(1)H(alpha), and (13)C(alpha)-13C' interactions in the previously well-studied protein domain GB3, dissolved in a liquid crystalline suspension of filamentous phage Pf1. Alignment variation is achieved by using conservative mutations of charged surface residues. Results indicate remarkably uniform backbone dynamics, with amplitudes that agree well with those of previous (15)N relaxation studies for most residues involved in elements of secondary structure, but larger amplitude dynamics than those found by (15)N relaxation for residues in loop and turn regions. In agreement with a previous analysis of dipolar couplings, the N-H bonds in the second beta-strand, which is involved in antibody recognition, show elevated dynamics with largest amplitudes orthogonal to the chain direction. JF - The journal of physical chemistry. B AU - Yao, Lishan AU - Vögeli, Beat AU - Torchia, Dennis A AU - Bax, Ad AD - Laboratory of Chemical Physics, NIDDK, and National Institute of Dental and Cranofacial Research, National Institutes of Health, Bethesda, Maryland 20892-0520, USA. Y1 - 2008/05/15/ PY - 2008 DA - 2008 May 15 SP - 6045 EP - 6056 VL - 112 IS - 19 SN - 1520-6106, 1520-6106 KW - Proteins KW - 0 KW - Index Medicus KW - Mutation -- genetics KW - Proteins -- chemistry KW - Nuclear Magnetic Resonance, Biomolecular -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69187259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+physical+chemistry.+B&rft.atitle=Simultaneous+NMR+study+of+protein+structure+and+dynamics+using+conservative+mutagenesis.&rft.au=Yao%2C+Lishan%3BV%C3%B6geli%2C+Beat%3BTorchia%2C+Dennis+A%3BBax%2C+Ad&rft.aulast=Yao&rft.aufirst=Lishan&rft.date=2008-05-15&rft.volume=112&rft.issue=19&rft.spage=6045&rft.isbn=&rft.btitle=&rft.title=The+journal+of+physical+chemistry.+B&rft.issn=15206106&rft_id=info:doi/10.1021%2Fjp0772124 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-13 N1 - Date created - 2008-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jp0772124 ER - TY - JOUR T1 - Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation? AN - 69173228; 18453594 AB - KIR3DL1 shows extensive polymorphism, and its variation has functional significance in terms of cell-surface expression levels and inhibitory capacity. We characterized nine KIR3DL1 alleles (*022, *028, *029, *033, *035, *051, *052, *053, and *054), four of which were identified for the first time in this study, and compared them to known alleles in phylogenetic analysis. Blood was available from eight individuals with these alleles, and cell-surface expression on NK cells could be determined for six of them using the KIR3DL1-specific Ab DX9. Four of the alleles were expressed at clearly detectable levels, and two others showed exceptionally low levels of expression. Site-directed mutagenesis demonstrated that single amino acid changes can result in either diminished or enhanced DX9 staining compared with the respective related KIR3DL1 allotypes. These results raise the possibility that KIR3DL1 evolution maintains variation in KIR3DL1 cell-surface expression levels, potentially due to the effect of such variation on functional capacity. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Thomas, Rasmi AU - Yamada, Eriko AU - Alter, Galit AU - Martin, Maureen P AU - Bashirova, Arman A AU - Norman, Paul J AU - Altfeld, Marcus AU - Parham, Peter AU - Anderson, Stephen K AU - McVicar, Daniel W AU - Carrington, Mary AD - Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2008/05/15/ PY - 2008 DA - 2008 May 15 SP - 6743 EP - 6750 VL - 180 IS - 10 SN - 0022-1767, 0022-1767 KW - KIR3DL1 protein, human KW - 0 KW - Receptors, KIR3DL1 KW - Abridged Index Medicus KW - Index Medicus KW - Phylogeny KW - Phenotype KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Promoter Regions, Genetic KW - Polymorphism, Genetic KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Flow Cytometry KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Alleles KW - Gene Expression KW - Killer Cells, Natural -- physiology KW - Receptors, KIR3DL1 -- genetics KW - Evolution, Molecular KW - Receptors, KIR3DL1 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69173228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Novel+KIR3DL1+alleles+and+their+expression+levels+on+NK+cells%3A+convergent+evolution+of+KIR3DL1+phenotype+variation%3F&rft.au=Thomas%2C+Rasmi%3BYamada%2C+Eriko%3BAlter%2C+Galit%3BMartin%2C+Maureen+P%3BBashirova%2C+Arman+A%3BNorman%2C+Paul+J%3BAltfeld%2C+Marcus%3BParham%2C+Peter%3BAnderson%2C+Stephen+K%3BMcVicar%2C+Daniel+W%3BCarrington%2C+Mary&rft.aulast=Thomas&rft.aufirst=Rasmi&rft.date=2008-05-15&rft.volume=180&rft.issue=10&rft.spage=6743&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4778-83 [10781084] Methods Mol Biol. 2008;415:49-64 [18370147] J Immunol. 2001 Mar 1;166(5):2992-3001 [11207248] Nat Immunol. 2001 May;2(5):430-5 [11323697] Annu Rev Immunol. 2002;20:217-51 [11861603] Mol Immunol. 2002 May;38(14):1007-21 [11955593] Nat Genet. 2002 Aug;31(4):429-34 [12134147] J Exp Med. 2002 Oct 7;196(7):911-21 [12370253] Hum Immunol. 2003 Jun;64(6):648-54 [12770798] J Immunol. 2003 Jun 15;170(12):6073-81 [12794136] Nucleic Acids Res. 2003 Jul 1;31(13):3381-5 [12824332] J Immunol. 2003 Sep 1;171(5):2192-5 [12928362] J Immunol. 2003 Dec 15;171(12):6640-9 [14662867] Trends Genet. 2004 Apr;20(4):196-205 [15041174] Mol Biol Evol. 1987 Jul;4(4):406-25 [3447015] J Exp Med. 1994 Aug 1;180(2):537-43 [8046332] J Exp Med. 1994 Oct 1;180(4):1235-42 [7931060] J Biol Chem. 1996 Mar 1;271(9):4699-708 [8617735] Immunity. 1997 Dec;7(6):753-63 [9430221] Immunogenetics. 1998 Nov-Dec;48(6):413-6 [9799338] Nucleic Acids Res. 2005 Jan 1;33(Database issue):D523-6 [15608253] Annu Rev Immunol. 2005;23:225-74 [15771571] Nature. 2005 Aug 4;436(7051):709-13 [16079848] J Immunol. 2005 Oct 15;175(8):5222-9 [16210627] Nat Rev Immunol. 2005 Nov;5(11):835-43 [16239902] J Exp Med. 2006 Mar 20;203(3):633-45 [16533882] Immunogenetics. 2006 Jun;58(5-6):474-80 [16738943] J Immunol. 2007 Jan 1;178(1):33-7 [17182537] J Immunol. 2007 Jan 1;178(1):235-41 [17182560] J Immunol. 2007 Jan 15;178(2):647-51 [17202323] Eur J Immunol. 2007 Mar;37(3):780-7 [17301953] Genes Immun. 2007 Apr;8(3):245-53 [17315044] Nat Genet. 2007 Jun;39(6):733-40 [17496894] J Immunol. 2007 Aug 1;179(3):1625-33 [17641029] Nat Genet. 2007 Sep;39(9):1092-9 [17694054] Nat Genet. 2007 Sep;39(9):1114-9 [17694058] Tissue Antigens. 2001 Jan;57(1):22-31 [11169255] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Rational Vaccine Design and the Development of an AIDS Vaccine T2 - 2008 Keystone Symposia on Translating New Technologies to Improve Public Health in Africa (E1) AN - 40914804; 4847118 JF - 2008 Keystone Symposia on Translating New Technologies to Improve Public Health in Africa (E1) AU - Nabel, Gary J Y1 - 2008/05/15/ PY - 2008 DA - 2008 May 15 KW - Vaccines KW - Acquired immune deficiency syndrome KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40914804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Translating+New+Technologies+to+Improve+Public+Health+in+Africa+%28E1%29&rft.atitle=Rational+Vaccine+Design+and+the+Development+of+an+AIDS+Vaccine&rft.au=Nabel%2C+Gary+J&rft.aulast=Nabel&rft.aufirst=Gary&rft.date=2008-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Translating+New+Technologies+to+Improve+Public+Health+in+Africa+%28E1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=93 0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Incident Diabetes and Pesticide Exposure among Licensed Pesticide Applicators: Agricultural Health Study, 1993-2003 AN - 19583164; 8509145 AB - Exposure to certain environmental toxicants may be associated with increased risk of developing diabetes. The authors' aim was to investigate the relation between lifetime exposure to specific agricultural pesticides and diabetes incidence among pesticide applicators. The study included 33,457 licensed applicators, predominantly non-Hispanic White males, enrolled in the Agricultural Health Study. Incident diabetes was self-reported in a 5-year follow-up interview (1999-2003), giving 1,176 diabetics and 30,611 nondiabetics for analysis. Lifetime exposure to pesticides and covariate information were reported by participants at enrollment (1993-1997). Using logistic regression, the authors considered two primary measures of pesticide exposure: ever use and cumulative lifetime days of use. They found seven specific pesticides (aldrin, chlordane, heptachlor, dichlorvos, trichlorfon, alachlor, and cyanazine) for which the odds of diabetes incidence increased with both ever use and cumulative days of use. Applicators who had used the organochlorine insecticides aldrin, chlordane, and heptachlor more than 100 lifetime days had 51%, 63%, and 94% increased odds of diabetes, respectively. The observed association of organochlorine and organophosphate insecticides with diabetes is consistent with results from previous human and animal studies. Long-term exposure from handling certain pesticides, in particular, organochlorine and organophosphate insecticides, may be associated with increased risk of diabetes. JF - American Journal of Epidemiology AU - Montgomery, M P AU - Kamel, F AU - Saldana, T M AU - Alavanja, MCR AU - Sandler, D P AD - 1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, sandler@niehs.nih.gov Y1 - 2008/05/15/ PY - 2008 DA - 2008 May 15 SP - 1235 EP - 1246 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 167 IS - 10 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - agrochemicals KW - diabetes mellitus KW - environmental exposure KW - hydrocarbons, chlorinated KW - insecticides KW - pesticides KW - phosphoric acid esters KW - Organochlorine compounds KW - Toxicants KW - Organophosphates KW - Aldrin KW - Insecticides KW - Occupational exposure KW - Dichlorvos KW - Pesticides (organophosphorus) KW - heptachlor KW - Chlordane KW - dichlorvos KW - Alachlor KW - Herbicides KW - organophosphates KW - Diabetes mellitus KW - Heptachlor KW - Pesticides KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19583164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Incident+Diabetes+and+Pesticide+Exposure+among+Licensed+Pesticide+Applicators%3A+Agricultural+Health+Study%2C+1993-2003&rft.au=Montgomery%2C+M+P%3BKamel%2C+F%3BSaldana%2C+T+M%3BAlavanja%2C+MCR%3BSandler%2C+D+P&rft.aulast=Montgomery&rft.aufirst=M&rft.date=2008-05-15&rft.volume=167&rft.issue=10&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwn028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Pesticides (organophosphorus); Organochlorine compounds; Insecticides; Toxicants; Chlordane; heptachlor; Aldrin; Pesticides; Alachlor; organophosphates; Dichlorvos; Organophosphates; dichlorvos; Herbicides; diabetes mellitus; Heptachlor; Occupational exposure DO - http://dx.doi.org/10.1093/aje/kwn028 ER - TY - CPAPER T1 - What is the Energy Deficit Required Per Unit Weight Loss? T2 - 16th European Congress on Obesity (ECO 2008) AN - 41059054; 4911713 JF - 16th European Congress on Obesity (ECO 2008) AU - Hall, K D Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Energy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41059054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+European+Congress+on+Obesity+%28ECO+2008%29&rft.atitle=What+is+the+Energy+Deficit+Required+Per+Unit+Weight+Loss%3F&rft.au=Hall%2C+K+D&rft.aulast=Hall&rft.aufirst=K&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+European+Congress+on+Obesity+%28ECO+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/ijo/journal/v32/n1s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes of Visceral Fat are Allometrically Related to Total Body Fat Independently of Gender or Weight Loss Intervention T2 - 16th European Congress on Obesity (ECO 2008) AN - 41057232; 4911854 JF - 16th European Congress on Obesity (ECO 2008) AU - Hall, K D AU - Hallgreen, C E Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Sex KW - Intervention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41057232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+European+Congress+on+Obesity+%28ECO+2008%29&rft.atitle=Changes+of+Visceral+Fat+are+Allometrically+Related+to+Total+Body+Fat+Independently+of+Gender+or+Weight+Loss+Intervention&rft.au=Hall%2C+K+D%3BHallgreen%2C+C+E&rft.aulast=Hall&rft.aufirst=K&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+European+Congress+on+Obesity+%28ECO+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/ijo/journal/v32/n1s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel N-Terminal pparg Coactivator Involved in Adipogenesis T2 - 16th European Congress on Obesity (ECO 2008) AN - 41051898; 4911379 JF - 16th European Congress on Obesity (ECO 2008) AU - Meruvu, S AU - Hugendubler, L AU - Mueller, E Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Adipogenesis KW - Peroxisome proliferator-activated receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41051898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+European+Congress+on+Obesity+%28ECO+2008%29&rft.atitle=Identification+of+a+Novel+N-Terminal+pparg+Coactivator+Involved+in+Adipogenesis&rft.au=Meruvu%2C+S%3BHugendubler%2C+L%3BMueller%2C+E&rft.aulast=Meruvu&rft.aufirst=S&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+European+Congress+on+Obesity+%28ECO+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/ijo/journal/v32/n1s/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Self-Antigens on Bone Marrow-Derived Dendritic Cells Induce Peripheral Tolerance to Self-Antigen-Specific TCR-Transgenic CD8@@u+@ T Cells T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40966214; 4867381 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Cho, Y AU - Miyagawa, F AU - Gutermuth, J AU - Udey, M C AU - Katz, S I Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Bone marrow KW - Autoantigens KW - T-cell receptor KW - CD8 antigen KW - Dendritic cells KW - Lymphocytes T KW - Immunological tolerance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40966214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Expression+of+Self-Antigens+on+Bone+Marrow-Derived+Dendritic+Cells+Induce+Peripheral+Tolerance+to+Self-Antigen-Specific+TCR-Transgenic+CD8%40%40u%2B%40+T+Cells&rft.au=Cho%2C+Y%3BMiyagawa%2C+F%3BGutermuth%2C+J%3BUdey%2C+M+C%3BKatz%2C+S+I&rft.aulast=Cho&rft.aufirst=Y&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trichothiodystrophy: A Multisystem Genetic Disease with Striking Phenotypic Diversity T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40964234; 4868548 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Mahindra, P AU - Faghri, S AU - DiGiovanna, J J AU - Tamura, D AU - Kraemer, K H Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Trichothiodystrophy A KW - Genetic diversity KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40964234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Trichothiodystrophy%3A+A+Multisystem+Genetic+Disease+with+Striking+Phenotypic+Diversity&rft.au=Mahindra%2C+P%3BFaghri%2C+S%3BDiGiovanna%2C+J+J%3BTamura%2C+D%3BKraemer%2C+K+H&rft.aulast=Mahindra&rft.aufirst=P&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-15 is a Critical Costimulator in Determining the Activity of Autoreactive CD8 T Cells T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40963630; 4867385 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Miyagawa, F AU - Tagaya, Y AU - Katz, S I Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - CD8 antigen KW - Lymphocytes T KW - Interleukin 15 KW - Costimulator UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40963630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=IL-15+is+a+Critical+Costimulator+in+Determining+the+Activity+of+Autoreactive+CD8+T+Cells&rft.au=Miyagawa%2C+F%3BTagaya%2C+Y%3BKatz%2C+S+I&rft.aulast=Miyagawa&rft.aufirst=F&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defining PKCa Transcriptome in Transgenic Keratinocytes Reveals Unique Signatures for Downstream Signaling in the AP-1 and NF-kB Pathways T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40962465; 4868470 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Cataisson, C AU - Pearson, A AU - Michalowska, A AU - Patel, G AU - Yuspa, S Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Downstream KW - Signal transduction KW - NF-B protein KW - Keratinocytes KW - Protein kinase C UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40962465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Defining+PKCa+Transcriptome+in+Transgenic+Keratinocytes+Reveals+Unique+Signatures+for+Downstream+Signaling+in+the+AP-1+and+NF-kB+Pathways&rft.au=Cataisson%2C+C%3BPearson%2C+A%3BMichalowska%2C+A%3BPatel%2C+G%3BYuspa%2C+S&rft.aulast=Cataisson&rft.aufirst=C&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BHD Mutations, Clinical and Genotype-Phenotype Investigations of 351 Cases with Birt-Hogg-Dube Syndrome T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40962322; 4868437 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Toro, J R Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Mutation KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40962322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=BHD+Mutations%2C+Clinical+and+Genotype-Phenotype+Investigations+of+351+Cases+with+Birt-Hogg-Dube+Syndrome&rft.au=Toro%2C+J+R&rft.aulast=Toro&rft.aufirst=J&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - EGFR Regulates Keratinocytes GM-CSF Expression In Vitro and In Vivo: Updates on the Role of EGFR in Skin Immune Regulation T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40961337; 4868471 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Mascia, F AU - Cataisson, C AU - Chandrasekhara, C AU - Girolomoni, G AU - Mariani, V AU - Yuspa, S H AU - Pastore, S Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Skin KW - Epidermal growth factor receptors KW - Granulocyte-macrophage colony-stimulating factor KW - Immunoregulation KW - Keratinocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40961337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=EGFR+Regulates+Keratinocytes+GM-CSF+Expression+In+Vitro+and+In+Vivo%3A+Updates+on+the+Role+of+EGFR+in+Skin+Immune+Regulation&rft.au=Mascia%2C+F%3BCataisson%2C+C%3BChandrasekhara%2C+C%3BGirolomoni%2C+G%3BMariani%2C+V%3BYuspa%2C+S+H%3BPastore%2C+S&rft.aulast=Mascia&rft.aufirst=F&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Genomics Approach to Identify Cis-Regulatory Elements in the Epidermal Differentiation Complex (EDC) T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40959881; 4868429 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - de Guzman Strong, C AU - Sears, K AU - Segre, J A Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Differentiation KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40959881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=A+Genomics+Approach+to+Identify+Cis-Regulatory+Elements+in+the+Epidermal+Differentiation+Complex+%28EDC%29&rft.au=de+Guzman+Strong%2C+C%3BSears%2C+K%3BSegre%2C+J+A&rft.aulast=de+Guzman+Strong&rft.aufirst=C&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential EpCAM Expression and Growth Factor Requirements Reveal Heterogeneity of Dendritic Cells in Murine Skin T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40958878; 4867384 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Nagao, K AU - Ginhoux, F AU - Clausen, B E AU - Merad, M AU - Udey, M C Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Skin KW - Growth factors KW - Dendritic cells KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40958878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Differential+EpCAM+Expression+and+Growth+Factor+Requirements+Reveal+Heterogeneity+of+Dendritic+Cells+in+Murine+Skin&rft.au=Nagao%2C+K%3BGinhoux%2C+F%3BClausen%2C+B+E%3BMerad%2C+M%3BUdey%2C+M+C&rft.aulast=Nagao&rft.aufirst=K&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Dlx3 in Hair Development T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40958643; 4868599 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Morasso, M I AU - Hwang, J AU - Millar, S E AU - Mehrani, T Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Hair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40958643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=The+Role+of+Dlx3+in+Hair+Development&rft.au=Morasso%2C+M+I%3BHwang%2C+J%3BMillar%2C+S+E%3BMehrani%2C+T&rft.aulast=Morasso&rft.aufirst=M&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhancement of DNA-Vaccine Induced Protection Against Lymphoma Using Limiting Amounts of Helper Plasmid-Encoded Antigen T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40958487; 4867383 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Leitner, W W AU - Baker, M C AU - Lu, M. AU - Dejesus, G L AU - Yannie, P J AU - Udey, M C Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Lymphoma KW - Antigens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40958487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Enhancement+of+DNA-Vaccine+Induced+Protection+Against+Lymphoma+Using+Limiting+Amounts+of+Helper+Plasmid-Encoded+Antigen&rft.au=Leitner%2C+W+W%3BBaker%2C+M+C%3BLu%2C+M.%3BDejesus%2C+G+L%3BYannie%2C+P+J%3BUdey%2C+M+C&rft.aulast=Leitner&rft.aufirst=W&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Skin Gene Therapy can be Used to Deliver Anti-Hypertensive Atrial Natriuretic Peptide (ANP) in Order to Prevent Blood Pressure Elevation in High-Salt Diet Immunocompromised Mice T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40958061; 4868383 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Therrien, J P AU - Kim, S AU - Terunuma, A AU - Qin, Y AU - Tock, C L AU - Pfutzner, W AU - Schernmann, J AU - Vogel, J C Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Diets KW - Skin KW - Mice KW - Blood pressure KW - Atrial natriuretic peptide KW - Gene therapy KW - Peptides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40958061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Human+Skin+Gene+Therapy+can+be+Used+to+Deliver+Anti-Hypertensive+Atrial+Natriuretic+Peptide+%28ANP%29+in+Order+to+Prevent+Blood+Pressure+Elevation+in+High-Salt+Diet+Immunocompromised+Mice&rft.au=Therrien%2C+J+P%3BKim%2C+S%3BTerunuma%2C+A%3BQin%2C+Y%3BTock%2C+C+L%3BPfutzner%2C+W%3BSchernmann%2C+J%3BVogel%2C+J+C&rft.aulast=Therrien&rft.aufirst=J&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Analysis of the Cutaneous Skin Microflora T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40956299; 4868380 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Grice, E A AU - Kong, H H AU - Renaud, G AU - Young, A C AU - Program, N AU - Bouffard, G G AU - Blakesley, R W AU - Wolfsberg, T G AU - Turner, M L AU - Segre, J A Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Microflora KW - Skin KW - Genomic analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40956299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Genomic+Analysis+of+the+Cutaneous+Skin+Microflora&rft.au=Grice%2C+E+A%3BKong%2C+H+H%3BRenaud%2C+G%3BYoung%2C+A+C%3BProgram%2C+N%3BBouffard%2C+G+G%3BBlakesley%2C+R+W%3BWolfsberg%2C+T+G%3BTurner%2C+M+L%3BSegre%2C+J+A&rft.aulast=Grice&rft.aufirst=E&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Skin Tumor Chemotherapeutic Agent PEP005 is a Substrate for the Multidrug Resistance Protein MDR1 and Damages Tumor Vascularity T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40955735; 4868069 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Li, L. AU - Shukla, S AU - Yuspa, S H Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Tumors KW - Skin KW - Chemotherapy KW - P-Glycoprotein KW - Multidrug resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40955735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=The+Skin+Tumor+Chemotherapeutic+Agent+PEP005+is+a+Substrate+for+the+Multidrug+Resistance+Protein+MDR1+and+Damages+Tumor+Vascularity&rft.au=Li%2C+L.%3BShukla%2C+S%3BYuspa%2C+S+H&rft.aulast=Li&rft.aufirst=L.&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ancient Origin of a Japanese Xeroderma Pigmentosum Founder Mutation T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40954326; 4867767 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Imoto, K AU - Nadem, C AU - Moriwaki, S AU - Nishigori, C AU - Oh, K. AU - Khan, S G AU - Goldstein, A M AU - Kraemer, K H Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Japan KW - Mutation KW - Xeroderma pigmentosum UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40954326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Ancient+Origin+of+a+Japanese+Xeroderma+Pigmentosum+Founder+Mutation&rft.au=Imoto%2C+K%3BNadem%2C+C%3BMoriwaki%2C+S%3BNishigori%2C+C%3BOh%2C+K.%3BKhan%2C+S+G%3BGoldstein%2C+A+M%3BKraemer%2C+K+H&rft.aulast=Imoto&rft.aufirst=K&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Internal Repeat Domain of the Melanosomal Matrix Protein PMEL17/GP100 is Required for Fibrillogenesis T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40953317; 4867705 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Hoashi, T AU - Muller, J AU - Tamaki, K AU - Ohara, K AU - Hearing, V J Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Fibrillogenesis KW - Glycoprotein gp100 KW - Matrix protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40953317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=The+Internal+Repeat+Domain+of+the+Melanosomal+Matrix+Protein+PMEL17%2FGP100+is+Required+for+Fibrillogenesis&rft.au=Hoashi%2C+T%3BMuller%2C+J%3BTamaki%2C+K%3BOhara%2C+K%3BHearing%2C+V+J&rft.aulast=Hoashi&rft.aufirst=T&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spectrum of Sorafenib-Induced Dermatologic Adverse Effects T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40952297; 4868095 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Kong, H H AU - Azad, N S AU - Aragon-Ching, J B AU - Gutierrez, M AU - Dahut, W L AU - Kohn, E C AU - Turner, M L Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40952297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Spectrum+of+Sorafenib-Induced+Dermatologic+Adverse+Effects&rft.au=Kong%2C+H+H%3BAzad%2C+N+S%3BAragon-Ching%2C+J+B%3BGutierrez%2C+M%3BDahut%2C+W+L%3BKohn%2C+E+C%3BTurner%2C+M+L&rft.aulast=Kong&rft.aufirst=H&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Melanocyte Label-Retaining Cells (LRCs) by Microarray Analysis T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40952137; 4867721 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Hwang, H AU - Diwakar, G AU - Jiang, S AU - Michalowska, A AU - Zaidi, R AU - Merlino, G AU - Hornyak, T J Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Melanocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40952137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Characterization+of+Melanocyte+Label-Retaining+Cells+%28LRCs%29+by+Microarray+Analysis&rft.au=Hwang%2C+H%3BDiwakar%2C+G%3BJiang%2C+S%3BMichalowska%2C+A%3BZaidi%2C+R%3BMerlino%2C+G%3BHornyak%2C+T+J&rft.aulast=Hwang&rft.aufirst=H&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Human Non-Melanoma Skin Cancer Stem Cell Assays. T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40950939; 4867802 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Patel, G K AU - Yee, C L AU - Montemarano, A AU - Maggio, K AU - Vogel, J C Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Skin cancer KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40950939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Development+of+Human+Non-Melanoma+Skin+Cancer+Stem+Cell+Assays.&rft.au=Patel%2C+G+K%3BYee%2C+C+L%3BMontemarano%2C+A%3BMaggio%2C+K%3BVogel%2C+J+C&rft.aulast=Patel&rft.aufirst=G&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Isomorphic Response in Sclerotic-Type Chronic Graft-Versus-Host Disease T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40950432; 4867987 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Patel, A R AU - Turner, M L AU - Pavletic, S Z AU - Cowen, E W Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Graft-versus-host reaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40950432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=The+Isomorphic+Response+in+Sclerotic-Type+Chronic+Graft-Versus-Host+Disease&rft.au=Patel%2C+A+R%3BTurner%2C+M+L%3BPavletic%2C+S+Z%3BCowen%2C+E+W&rft.aulast=Patel&rft.aufirst=A&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cutaneous Soft Tissue Sarcoma Incidence Patterns in the Surveillance, Epidemiology, and End Results Program, 1978-2004: An Analysis of 12,114 Cases T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40949749; 4868159 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Rouhani, P AU - Fletcher, C D AU - Devesa, S AU - Toro, J R Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Epidemiology KW - Soft tissue sarcoma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40949749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Cutaneous+Soft+Tissue+Sarcoma+Incidence+Patterns+in+the+Surveillance%2C+Epidemiology%2C+and+End+Results+Program%2C+1978-2004%3A+An+Analysis+of+12%2C114+Cases&rft.au=Rouhani%2C+P%3BFletcher%2C+C+D%3BDevesa%2C+S%3BToro%2C+J+R&rft.aulast=Rouhani&rft.aufirst=P&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarray Analysis of Ras-Transformed Keratinocytes Genetically or Pharmacologically Ablated for the Epidermal Growth Factor Receptor (EGFR) Reveals Genetic Signature and Off-target Drug Effects. T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40949680; 4867797 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Wright, L N AU - Riss, J AU - Ryscavage, A AU - Yuspa, S H Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Drugs KW - Growth factors KW - Epidermal growth factor receptors KW - Keratinocytes KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40949680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Microarray+Analysis+of+Ras-Transformed+Keratinocytes+Genetically+or+Pharmacologically+Ablated+for+the+Epidermal+Growth+Factor+Receptor+%28EGFR%29+Reveals+Genetic+Signature+and+Off-target+Drug+Effects.&rft.au=Wright%2C+L+N%3BRiss%2C+J%3BRyscavage%2C+A%3BYuspa%2C+S+H&rft.aulast=Wright&rft.aufirst=L&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CC Chemokine Receptor-6 (CCR6) is Essential for IL-23-Mediated Psoriasiform Dermatitis in a Murine Model of Psoriasis T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40949588; 4868267 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Lonsdorf, A S AU - Hedrick, M N AU - Shirakawa, A AU - Farber, J M AU - Hwang, S T Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Psoriasis KW - Dermatitis KW - Animal models KW - CCR6 protein KW - CC chemokines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40949588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=CC+Chemokine+Receptor-6+%28CCR6%29+is+Essential+for+IL-23-Mediated+Psoriasiform+Dermatitis+in+a+Murine+Model+of+Psoriasis&rft.au=Lonsdorf%2C+A+S%3BHedrick%2C+M+N%3BShirakawa%2C+A%3BFarber%2C+J+M%3BHwang%2C+S+T&rft.aulast=Lonsdorf&rft.aufirst=A&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Germline Mutations in the Fumarate Hydratase Gene Confer a Predisposition to Uterine Fibroids in Women with Hereditary Leiomyomatosis and Renal Cell Cancer T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40949424; 4868158 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Stewart, L AU - Glenn, G M AU - Stratton, P AU - Goldstein, A AU - Merino, M J AU - Tucker, M A AU - Linehan, W AU - Toro, J R Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Uterine cancer KW - Mutation KW - Fumarate hydratase KW - Uterus KW - Kidneys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40949424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Germline+Mutations+in+the+Fumarate+Hydratase+Gene+Confer+a+Predisposition+to+Uterine+Fibroids+in+Women+with+Hereditary+Leiomyomatosis+and+Renal+Cell+Cancer&rft.au=Stewart%2C+L%3BGlenn%2C+G+M%3BStratton%2C+P%3BGoldstein%2C+A%3BMerino%2C+M+J%3BTucker%2C+M+A%3BLinehan%2C+W%3BToro%2C+J+R&rft.aulast=Stewart&rft.aufirst=L&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transglutaminase-1 Gene Mutations in Autosomal Recessive Congenital Ichthyosis: Clinical and Genetic Investigations in a Large Cohort of 108 Patients T2 - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AN - 40945343; 4868318 JF - 2008 International Investigative Dermatology (Fifth Joint Meeting of the European Society for Dermatological Reserch, Japanese Society for Investigative Dermatology, Society for Investigative Dermatology) AU - Farasat, S AU - Wei, M H AU - Liewehr, D J AU - Steinberg, S M AU - Bale, S J AU - Fleckman, P AU - Toro, J R Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Point mutation KW - Ichthyosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40945343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.atitle=Transglutaminase-1+Gene+Mutations+in+Autosomal+Recessive+Congenital+Ichthyosis%3A+Clinical+and+Genetic+Investigations+in+a+Large+Cohort+of+108+Patients&rft.au=Farasat%2C+S%3BWei%2C+M+H%3BLiewehr%2C+D+J%3BSteinberg%2C+S+M%3BBale%2C+S+J%3BFleckman%2C+P%3BToro%2C+J+R&rft.aulast=Farasat&rft.aufirst=S&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Investigative+Dermatology+%28Fifth+Joint+Meeting+of+the+European+Society+for+Dermatological+Reserch%2C+Japanese+Society+for+Investigative+Dermatology%2C+Society+for+Investigative+Dermatology%29&rft.issn=&rft_id=info:doi/ L2 - http://iid2008.abstractcentral.com/viewer LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correcting Surface Coil Intensity Inhomogeneity Improves Quantitative Analysis of Cardiac Magnetic Resonance Images T2 - Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) AN - 40914660; 4847056 JF - Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) AU - Hsu, Li-Yueh AU - Aletras, Anthony AU - Arai, Andrew Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Magnetic resonance imaging KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40914660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifth+IEEE+International+Symposium+on+Biomedical+Imaging%3A+From+Nano+to+Macro+%28ISBI+2008%29&rft.atitle=Correcting+Surface+Coil+Intensity+Inhomogeneity+Improves+Quantitative+Analysis+of+Cardiac+Magnetic+Resonance+Images&rft.au=Hsu%2C+Li-Yueh%3BAletras%2C+Anthony%3BArai%2C+Andrew&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifth+IEEE+International+Symposium+on+Biomedical+Imaging%3A+From+Nano+to+Macro+%28ISBI+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomedicalimaging.org/RegularProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time-Resolved Cardiac CT Reconstruction Using the Ensemble Kalman Filter T2 - Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) AN - 40913192; 4847072 JF - Fifth IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI 2008) AU - George, Ashvin AU - Butala, Mark AU - Frazin, Richard AU - Kamalabadi, Farzad AU - Bresler, Yoram Y1 - 2008/05/14/ PY - 2008 DA - 2008 May 14 KW - Filters KW - Heart KW - Kalman filters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40913192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifth+IEEE+International+Symposium+on+Biomedical+Imaging%3A+From+Nano+to+Macro+%28ISBI+2008%29&rft.atitle=Time-Resolved+Cardiac+CT+Reconstruction+Using+the+Ensemble+Kalman+Filter&rft.au=George%2C+Ashvin%3BButala%2C+Mark%3BFrazin%2C+Richard%3BKamalabadi%2C+Farzad%3BBresler%2C+Yoram&rft.aulast=George&rft.aufirst=Ashvin&rft.date=2008-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifth+IEEE+International+Symposium+on+Biomedical+Imaging%3A+From+Nano+to+Macro+%28ISBI+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.biomedicalimaging.org/RegularProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A conserved poxvirus NlpC/P60 superfamily protein contributes to vaccinia virus virulence in mice but not to replication in cell culture AN - 19707527; 8186213 AB - Of the vaccinia virus genes that are conserved in all sequenced poxviruses, each one except for VACWR084 (G6R) has been at least partially characterized. The poxvirus protein encoded by G6R belongs to the NlpC/P60 superfamily, which consists of proteins with a papain-like fold and known or predicted protease, amidase or acyltransferase activity. The G6 protein was synthesized late in infection and localized to the interior of virions, primarily between the membrane and core. Unlike other conserved poxvirus genes, G6R was not required for virus propagation and spread in a variety of cells. Nevertheless, G6R null mutants caused less severe disease in mice than the parent or revertant virus. Moreover, mutation of the predicted catalytic cysteine led to the same level of attenuation as a null mutant, suggesting that the G6 protein has enzymatic activity that is important in vivo. Conservation of G6R amongst poxviruses and the disparity between its role in vitro and in vivo imply that the protein is involved in an aspect of the virus-host interaction that is common to vertebrates and insects. JF - Virology AU - Senkevich, T G AU - Wyatt, L S AU - Weisberg, A S AU - Koonin, E V AU - Moss, B AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, bmoss@nih.gov Y1 - 2008/05/10/ PY - 2008 DA - 2008 May 10 SP - 506 EP - 514 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 374 IS - 2 SN - 0042-6822, 0042-6822 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Virology & AIDS Abstracts KW - Virions KW - Replication KW - Amidase KW - Cell culture KW - Infection KW - Virulence KW - Vaccinia virus KW - Protein folding KW - Poxvirus KW - Cysteine KW - Acyltransferase KW - Conservation KW - Proteinase KW - Enzymatic activity KW - Revertants KW - Mutation KW - G 07750:Ecological & Population Genetics KW - V 22320:Replication KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19707527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=A+conserved+poxvirus+NlpC%2FP60+superfamily+protein+contributes+to+vaccinia+virus+virulence+in+mice+but+not+to+replication+in+cell+culture&rft.au=Senkevich%2C+T+G%3BWyatt%2C+L+S%3BWeisberg%2C+A+S%3BKoonin%2C+E+V%3BMoss%2C+B&rft.aulast=Senkevich&rft.aufirst=T&rft.date=2008-05-10&rft.volume=374&rft.issue=2&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2008.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virions; Amidase; Replication; Cell culture; Infection; Virulence; Protein folding; Acyltransferase; Cysteine; Conservation; Proteinase; Enzymatic activity; Mutation; Revertants; Vaccinia virus; Poxvirus DO - http://dx.doi.org/10.1016/j.virol.2008.01.009 ER - TY - JOUR T1 - Treating metastatic solid tumors with bortezomib and a tumor necrosis factor-related apoptosis-inducing ligand receptor agonist antibody. AN - 69186685; 18445820 AB - Resistance of tumors to cell death signals poses a complex clinical problem. We explored the therapeutic potential and in vivo toxicity of a combination of bortezomib, a proteasome inhibitor, and MD5-1, a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor (DR5) agonist monoclonal antibody, in mouse carcinomas. METHODS; Mice bearing Renca-FLAG (renal) or 4T1 (mammary) tumors were treated with bortezomib and/or MD5-1 and examined for lung metastases (Renca-FLAG: n = 93; 4T1: n = 40) or monitored for survival (Renca-FLAG: n = 143). Toxicity was assessed by histopathology and hematology. Viability and apoptotic signaling in Renca-FLAG and 4T1 cells treated with bortezomib alone or in combination with TRAIL were analyzed using 3-[4,5-dimethyiazol-2-yl-5]-[3-carboxymethyloxyphenyl]-2-[4-sulfophenyl]-2H tetrazolium assay and by measuring mitochondrial membrane depolarization and caspase-8 and caspase-3 activation. All statistical tests were two-sided. Bortezomib (20 nM) sensitized Renca-FLAG and 4T1 cells to TRAIL-mediated apoptosis (mean percent decrease in numbers of viable cells, bortezomib + TRAIL vs TRAIL: Renca-FLAG, 95% vs 34%, difference = 61%, 95% confidence interval [CI] = 52% to 69%, P < .001; 4T1, 85% vs 20%, difference = 65%, 95% CI = 62% to 69%, P < .001). Sensitization involved activation of caspase-8 and caspase-3 but not mitochondrial membrane depolarization, suggesting an amplified signaling of the extrinsic cell death pathway. Treatment with bortezomib and MD5-1 reduced lung metastases in mice carrying Renca and 4T1 tumors (mean number of metastases, bortezomib + MD5-1 vs MD5-1: Renca-FLAG, 1 vs 8, difference = 7, 95% CI = 5 to 9, P < .001; 4T1, 1 vs 12, difference = 11, 95% CI = 9 to 12, P < .001) and increased median survival of mice bearing Renca-FLAG tumors (bortezomib + MD5-1 vs bortezomib + control isotype antibody: 22 of 30 [73%] were still alive at day 180 vs median survival of 42 days [95% CI = 41 to 44 days, P < .001]) in the absence of obvious toxicity. Bortezomib combined with DR5 agonist monoclonal antibody may be a useful treatment for metastatic solid tumors. JF - Journal of the National Cancer Institute AU - Shanker, Anil AU - Brooks, Alan David AU - Tristan, Carlos Alberto AU - Wine, John William AU - Elliott, Peter John AU - Yagita, Hideo AU - Takeda, Kazuyoshi AU - Smyth, Mark John AU - Murphy, William Joseph AU - Sayers, Thomas Joseph AD - Laboratory of Experimental Immunology, Cancer and Inflammation Program, SAIC-Frederick, Inc, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2008/05/07/ PY - 2008 DA - 2008 May 07 SP - 649 EP - 662 VL - 100 IS - 9 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - Boronic Acids KW - Protease Inhibitors KW - Proto-Oncogene Proteins c-bcl-2 KW - Pyrazines KW - Receptors, TNF-Related Apoptosis-Inducing Ligand KW - TNF-Related Apoptosis-Inducing Ligand KW - Bortezomib KW - 69G8BD63PP KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 8 KW - Index Medicus KW - Caspase 8 -- metabolism KW - Protease Inhibitors -- pharmacology KW - Animals KW - Immunoblotting KW - Humans KW - Cell Line, Tumor KW - Mice KW - Mice, Inbred BALB C KW - Mitochondrial Membranes -- metabolism KW - Cell Survival -- drug effects KW - Signal Transduction -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Apoptosis -- drug effects KW - Flow Cytometry KW - Female KW - Caspase 3 -- metabolism KW - Boronic Acids -- pharmacology KW - Kidney Neoplasms -- drug therapy KW - Kidney Neoplasms -- pathology KW - Antineoplastic Agents -- administration & dosage KW - Mammary Neoplasms, Animal -- secondary KW - Lung Neoplasms -- secondary KW - Pyrazines -- pharmacology KW - Lung Neoplasms -- drug therapy KW - TNF-Related Apoptosis-Inducing Ligand -- metabolism KW - Antibodies, Monoclonal -- pharmacology KW - Receptors, TNF-Related Apoptosis-Inducing Ligand -- agonists KW - Antineoplastic Agents -- adverse effects KW - Adenocarcinoma -- secondary KW - Adenocarcinoma -- drug therapy KW - Antineoplastic Agents -- pharmacology KW - Mammary Neoplasms, Animal -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69186685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Treating+metastatic+solid+tumors+with+bortezomib+and+a+tumor+necrosis+factor-related+apoptosis-inducing+ligand+receptor+agonist+antibody.&rft.au=Shanker%2C+Anil%3BBrooks%2C+Alan+David%3BTristan%2C+Carlos+Alberto%3BWine%2C+John+William%3BElliott%2C+Peter+John%3BYagita%2C+Hideo%3BTakeda%2C+Kazuyoshi%3BSmyth%2C+Mark+John%3BMurphy%2C+William+Joseph%3BSayers%2C+Thomas+Joseph&rft.aulast=Shanker&rft.aufirst=Anil&rft.date=2008-05-07&rft.volume=100&rft.issue=9&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjn113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-23 N1 - Date created - 2008-05-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Death Differ. 2003 Jan;10(1):26-35 [12655293] Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):337-48 [12787570] Blood. 2003 Jul 1;102(1):303-10 [12637321] Oncogene. 2003 Aug 7;22(32):4953-63 [12902978] Clin Cancer Res. 2003 Oct 1;9(12):4537-45 [14555528] J Exp Med. 2004 Feb 16;199(4):437-48 [14769851] Oncogene. 2004 Apr 1;23(14):2554-8 [14691451] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8120-5 [15148407] J Biol Chem. 2004 Jul 9;279(28):29160-6 [15123689] Cancer Cell. 2004 Sep;6(3):297-305 [15380520] J Immunol Methods. 1987 Jun 26;100(1-2):123-30 [3598193] EMBO J. 1998 Mar 16;17(6):1675-87 [9501089] Nat Med. 1999 Feb;5(2):157-63 [9930862] Cancer Res. 1999 Jun 1;59(11):2615-22 [10363983] J Clin Invest. 1999 Jul;104(2):155-62 [10411544] Clin Chem. 2000 May;46(5):673-83 [10794750] Nat Med. 2001 Jan;7(1):94-100 [11135622] Cancer Res. 2001 Apr 1;61(7):3071-6 [11306489] Blood. 2001 Aug 1;98(3):795-804 [11468181] J Immunol. 2002 Feb 1;168(3):1356-61 [11801676] J Exp Med. 2002 Jan 21;195(2):161-9 [11805143] J Immunol. 2002 Apr 1;168(7):3484-92 [11907109] Cancer Res. 2002 Oct 15;62(20):5800-6 [12384541] Mol Cell Biol. 2003 Feb;23(3):777-90 [12529384] Immunity. 2003 Jan;18(1):1-6 [12530970] Mol Cell. 2003 Feb;11(2):529-41 [12620239] Cancer Res. 2003 Jan 1;63(1):207-13 [12517799] Mol Cancer Ther. 2005 Mar;4(3):443-9 [15767553] Blood. 2005 Apr 15;105(8):3255-62 [15613543] Clin Cancer Res. 2005 Apr 15;11(8):3126-35 [15837769] Cancer Biol Ther. 2005 Feb;4(2):139-63 [15725726] Cancer Res. 2005 May 1;65(9):3828-36 [15867381] Cancer Res. 2005 Jun 1;65(11):4902-8 [15930312] Clin Cancer Res. 2005 Jun 1;11(11):4259-65 [15930365] Hepatology. 2005 Sep;42(3):588-97 [16037944] Cancer Biol Ther. 2005 Jul;4(7):781-6 [16082182] Cancer Immunol Immunother. 2006 Jan;55(1):76-84 [15864587] Cancer Res. 2005 Dec 15;65(24):11658-66 [16357177] Immunol Cell Biol. 2006 Feb;84(1):87-98 [16405656] Eur J Immunol. 2006 Mar;36(3):681-9 [16479541] Cancer Res. 2006 Apr 1;66(7):3773-81 [16585204] J Biosci. 2006 Mar;31(1):137-55 [16595883] J Immunol. 2006 May 15;176(10):6302-12 [16670342] J Immunol. 2006 May 15;176(10):6347-55 [16670347] Nat Med. 2006 Jun;12(6):693-8 [16680149] Blood. 2006 Jul 15;108(2):551-8 [16537813] Apoptosis. 2006 Jul;11(7):1175-93 [16699949] Cancer Res. 2006 Aug 15;66(16):7840-2 [16861477] Mol Cancer Ther. 2006 Sep;5(9):2251-60 [16985059] J Immunol. 2008 Jan 1;180(1):163-70 [18097016] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djn113 ER - TY - JOUR T1 - Persistent organochlorine pesticides and risk of testicular germ cell tumors. AN - 69184556; 18445826 AB - Exposure to endocrine-disrupting chemicals, such as persistent organochlorine pesticides, has been suggested to increase the risk of testicular germ cell tumors (TGCTs). To study the relationship of POP exposure to TGCT risk, prediagnostic serum samples from 754 case subjects and 928 control subjects enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study were analyzed for cis-nonachlor, trans-nonachlor, oxychlordane, total chlordanes, beta-hexachlorocyclohexane, mirex, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and p,p'-dichlorodiphenyltrichloroethane. Adjusted odds ratios (ORs) and their associated 95% confidence intervals (CIs) for the risk of TGCT overall and for the histological subgroups, seminoma and nonseminoma, were estimated using multivariable logistic regression. All statistical tests were two-sided. TGCT risk was statistically significantly associated with higher plasma levels of p,p'-DDE (for highest quartile [Q4] vs lowest quartile [Q1], OR = 1.71, 95% CI = 1.23 to 2.38, P(trend) = .0002) and of two chlordane components, cis-nonachlor (Q4 vs Q1, OR = 1.56, 95% CI = 1.11 to 2.18, P(trend) = .009) and trans-nonachlor (Q4 vs Q1, OR = 1.46, 95% CI = 1.07 to 2.00, P(trend) = .026). Seminoma risk was statistically significantly associated with p,p'-DDE (Q4 vs Q1, OR = 1.91, 95% CI = 1.22 to 2.99, P(trend) = .0008), cis-nonachlor (Q4 vs Q1, OR = 1.93, 95% CI = 1.27 to 2.93, P(trend) = .0045), trans-nonachlor (Q4 vs Q1, OR = 1.72, 95% CI = 1.11 to 2.67, P(trend) = .033), and a chlordane metabolite, oxychlordane (Q4 vs Q1, OR = 1.64, 95% CI = 1.04 to 2.60, P(trend) = .048), whereas nonseminoma risk showed a statistically significant association with p,p'-DDE only (Q4 vs Q1, OR = 1.63, 95% CI = 1.10 to 2.42, P(trend) = .0044). Increased exposure to p,p'-DDE may be associated with the risk of both seminomatous and nonseminomatous TGCTs, whereas exposure to chlordane compounds and metabolites may be associated with the risk of seminoma. Because evidence suggests that TGCT is initiated in very early life, it is possible that exposure to these persistent organic pesticides during fetal life or via breast feeding may increase the risk of TGCT in young men. JF - Journal of the National Cancer Institute AU - McGlynn, Katherine A AU - Quraishi, Sabah M AU - Graubard, Barry I AU - Weber, Jean-Philippe AU - Rubertone, Mark V AU - Erickson, Ralph L AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852-7234, USA. mcglynnk@mail.nih.gov Y1 - 2008/05/07/ PY - 2008 DA - 2008 May 07 SP - 663 EP - 671 VL - 100 IS - 9 KW - Hydrocarbons, Chlorinated KW - 0 KW - Pesticides KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - DDT KW - CIW5S16655 KW - Index Medicus KW - Seminoma -- chemically induced KW - Humans KW - Multivariate Analysis KW - Pregnancy KW - Breast Feeding -- adverse effects KW - Hydrocarbons, Chlorinated -- toxicity KW - Logistic Models KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - United States -- epidemiology KW - Female KW - Male KW - Prenatal Exposure Delayed Effects KW - Neoplasms, Germ Cell and Embryonal -- ethnology KW - DDT -- toxicity KW - Testicular Neoplasms -- chemically induced KW - Environmental Exposure -- adverse effects KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Testicular Neoplasms -- ethnology KW - Neoplasms, Germ Cell and Embryonal -- chemically induced KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69184556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Persistent+organochlorine+pesticides+and+risk+of+testicular+germ+cell+tumors.&rft.au=McGlynn%2C+Katherine+A%3BQuraishi%2C+Sabah+M%3BGraubard%2C+Barry+I%3BWeber%2C+Jean-Philippe%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2008-05-07&rft.volume=100&rft.issue=9&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjn101 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-23 N1 - Date created - 2008-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djn101 ER - TY - CPAPER T1 - Dynamic Arterial Spin Labeling Functional MRI (DASL-FMRI) T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40942245; 4854903 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Paiva, Fernando F AU - Stefanovic, Bojana AU - Hirano, Yoshiyuki AU - Tannus, Alberto AU - Silva, Afonso C Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40942245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Dynamic+Arterial+Spin+Labeling+Functional+MRI+%28DASL-FMRI%29&rft.au=Paiva%2C+Fernando+F%3BStefanovic%2C+Bojana%3BHirano%2C+Yoshiyuki%3BTannus%2C+Alberto%3BSilva%2C+Afonso+C&rft.aulast=Paiva&rft.aufirst=Fernando&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Practical Glutathione Measurement in Human Brain at 3 T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40942171; 4854850 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - An, Li AU - Zhang, Yan AU - Thomasson, David M AU - Latour, Lawrence L AU - Baker, Eva H AU - Shen, Jun AU - Warach, Steven J Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Glutathione KW - Brain KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40942171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Practical+Glutathione+Measurement+in+Human+Brain+at+3+T&rft.au=An%2C+Li%3BZhang%2C+Yan%3BThomasson%2C+David+M%3BLatour%2C+Lawrence+L%3BBaker%2C+Eva+H%3BShen%2C+Jun%3BWarach%2C+Steven+J&rft.aulast=An&rft.aufirst=Li&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaptive Spectral Registration Method for Glutathione Measurement Using J-Difference Editing T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40942132; 4854847 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - An, Li AU - Zhang, Yan AU - Thomasson, David M AU - Latour, Lawrence L AU - Baker, Eva H AU - Shen, Jun AU - Warach, Steven J Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Glutathione KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40942132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Adaptive+Spectral+Registration+Method+for+Glutathione+Measurement+Using+J-Difference+Editing&rft.au=An%2C+Li%3BZhang%2C+Yan%3BThomasson%2C+David+M%3BLatour%2C+Lawrence+L%3BBaker%2C+Eva+H%3BShen%2C+Jun%3BWarach%2C+Steven+J&rft.aulast=An&rft.aufirst=Li&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A New Strategy to Measure Reduced Glutathione (GSH) at 3 and 4 Tesla Using an Optimized STEAM Sequence T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40940283; 4854849 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Yang, Shaolin AU - Yang, Yihong Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Glutathione KW - Steam KW - Coenzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40940283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=A+New+Strategy+to+Measure+Reduced+Glutathione+%28GSH%29+at+3+and+4+Tesla+Using+an+Optimized+STEAM+Sequence&rft.au=Yang%2C+Shaolin%3BYang%2C+Yihong&rft.aulast=Yang&rft.aufirst=Shaolin&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of the Glutamate-Glutamine Cycling Flux Using Two-Compartment Dynamic Metabolic Modeling is Sensitive to Astroglial Dilution T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40939963; 4855312 DE: JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Shen, Jun AU - Rothman, Douglas AU - Behar, Kevin Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40939963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Determination+of+the+Glutamate-Glutamine+Cycling+Flux+Using+Two-Compartment+Dynamic+Metabolic+Modeling+is+Sensitive+to+Astroglial+Dilution&rft.au=Shen%2C+Jun%3BRothman%2C+Douglas%3BBehar%2C+Kevin&rft.aulast=Shen&rft.aufirst=Jun&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time-Domain Finite-Difference/Finite-Element Hybrid Simulations of High-Field RF Coils T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40939708; 4855232 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Wang, Shumin AU - Duyn, Jeff H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Simulation KW - Hybrids KW - Mathematical models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40939708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Time-Domain+Finite-Difference%2FFinite-Element+Hybrid+Simulations+of+High-Field+RF+Coils&rft.au=Wang%2C+Shumin%3BDuyn%2C+Jeff+H&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Whole Shaft Visibility for Polymer-Based Active IMRI Catheters Using Hybrid Braided Tubes T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40939430; 4856531 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Kocaturk, Ozgur AU - Kim, Ann AU - Guttman, Michael A AU - Faranesh, Anthony AU - Derbyshire, Andrew J AU - Ratnayaka, Kanishka AU - Lederman, Robert J Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Hybrids KW - Visibility KW - Catheters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40939430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Whole+Shaft+Visibility+for+Polymer-Based+Active+IMRI+Catheters+Using+Hybrid+Braided+Tubes&rft.au=Kocaturk%2C+Ozgur%3BKim%2C+Ann%3BGuttman%2C+Michael+A%3BFaranesh%2C+Anthony%3BDerbyshire%2C+Andrew+J%3BRatnayaka%2C+Kanishka%3BLederman%2C+Robert+J&rft.aulast=Kocaturk&rft.aufirst=Ozgur&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arterial Spin Labeling Quantification of Cerebral Blood Flow and Cerebrovascular Reactivity to Carbon Dioxide in Normotensive and Hypertensive Rats: A Comparative Study T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40939303; 4854902 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Paiva, Fernando F AU - Henning, Erica C AU - Tannus, Alberto AU - Silva, Afonso C Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Comparative studies KW - Rats KW - Carbon dioxide KW - Cerebral blood flow KW - Blood circulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40939303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Arterial+Spin+Labeling+Quantification+of+Cerebral+Blood+Flow+and+Cerebrovascular+Reactivity+to+Carbon+Dioxide+in+Normotensive+and+Hypertensive+Rats%3A+A+Comparative+Study&rft.au=Paiva%2C+Fernando+F%3BHenning%2C+Erica+C%3BTannus%2C+Alberto%3BSilva%2C+Afonso+C&rft.aulast=Paiva&rft.aufirst=Fernando&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Implicit Reference-Based Group Registration of Diffusion Tensor Imaging T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40939162; 4856475 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Geng, Xiujuan AU - Gu, Hong AU - Ross, Thomas J AU - Christensen, Gary E AU - Yang, Yihong Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Diffusion KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40939162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Implicit+Reference-Based+Group+Registration+of+Diffusion+Tensor+Imaging&rft.au=Geng%2C+Xiujuan%3BGu%2C+Hong%3BRoss%2C+Thomas+J%3BChristensen%2C+Gary+E%3BYang%2C+Yihong&rft.aulast=Geng&rft.aufirst=Xiujuan&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deep Gray Matter Atrophy as an MRI Metric of Physical and Cognitive Impairment in Patients with Multiple Sclerosis T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40938365; 4853320 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Gallo, Antonio AU - Evangelou, Iordanis E AU - Ikonomidou, Vasiliki N AU - Kane, Robert L AU - Stern, Susan K AU - Ohayon, Joan M AU - Cantor, Fredric AU - Mcfarland, Henry AU - Bagnato, Francesca Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Magnetic resonance imaging KW - Atrophy KW - Cognitive ability KW - Substantia grisea KW - Multiple sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40938365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Deep+Gray+Matter+Atrophy+as+an+MRI+Metric+of+Physical+and+Cognitive+Impairment+in+Patients+with+Multiple+Sclerosis&rft.au=Gallo%2C+Antonio%3BEvangelou%2C+Iordanis+E%3BIkonomidou%2C+Vasiliki+N%3BKane%2C+Robert+L%3BStern%2C+Susan+K%3BOhayon%2C+Joan+M%3BCantor%2C+Fredric%3BMcfarland%2C+Henry%3BBagnato%2C+Francesca&rft.aulast=Gallo&rft.aufirst=Antonio&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Observation of Microscopic Diffusion Anisotropy in the Spinal Cord Using Double-Pulsed Gradient Spin Echo MRI T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40938104; 4856393 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Komlosh, Michal E AU - Lizak, Martin J AU - Horkay, Ferenc AU - Freidlin, Raisa Z AU - Basser, Peter J Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Diffusion KW - Spinal cord KW - Magnetic resonance imaging KW - Anisotropy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40938104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Observation+of+Microscopic+Diffusion+Anisotropy+in+the+Spinal+Cord+Using+Double-Pulsed+Gradient+Spin+Echo+MRI&rft.au=Komlosh%2C+Michal+E%3BLizak%2C+Martin+J%3BHorkay%2C+Ferenc%3BFreidlin%2C+Raisa+Z%3BBasser%2C+Peter+J&rft.aulast=Komlosh&rft.aufirst=Michal&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Resolution Diffusion Tensor Imaging at 3T with Radial-FSE T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40938051; 4856388 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Sarlls, Joelle E AU - Pierpaoli, Carlo Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Diffusion KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40938051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=High-Resolution+Diffusion+Tensor+Imaging+at+3T+with+Radial-FSE&rft.au=Sarlls%2C+Joelle+E%3BPierpaoli%2C+Carlo&rft.aulast=Sarlls&rft.aufirst=Joelle&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pseudo-Continuous Arterial Spin Labeling at 7T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40937677; 4853224 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Luh, Wen-Ming AU - Li, Tie-Qiang AU - Wong, Eric C AU - Bandettini, Peter A Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain KW - Spin labelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40937677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Pseudo-Continuous+Arterial+Spin+Labeling+at+7T&rft.au=Luh%2C+Wen-Ming%3BLi%2C+Tie-Qiang%3BWong%2C+Eric+C%3BBandettini%2C+Peter+A&rft.aulast=Luh&rft.aufirst=Wen-Ming&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SNR and Parallel Imaging Performance of a 32-Channel Array for Human Brain Imaging at 7 Tesla T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40936812; 4855203 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - de Zwart, Jacco A AU - van Gelderen, Peter AU - Wang, Shumin AU - Duyn, Jeff H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Neuroimaging KW - Imaging techniques KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40936812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=SNR+and+Parallel+Imaging+Performance+of+a+32-Channel+Array+for+Human+Brain+Imaging+at+7+Tesla&rft.au=de+Zwart%2C+Jacco+A%3Bvan+Gelderen%2C+Peter%3BWang%2C+Shumin%3BDuyn%2C+Jeff+H&rft.aulast=de+Zwart&rft.aufirst=Jacco&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Head Movement Correction for MRI with a Single Camera T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40936791; 4855275 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Qin, Lei AU - van Gelderen, Peter AU - de Zwart, Jacco AU - Jin, Fenghua AU - Tao, Yang AU - Duyn, Jeff H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Magnetic resonance imaging KW - Head KW - Cameras KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40936791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Head+Movement+Correction+for+MRI+with+a+Single+Camera&rft.au=Qin%2C+Lei%3Bvan+Gelderen%2C+Peter%3Bde+Zwart%2C+Jacco%3BJin%2C+Fenghua%3BTao%2C+Yang%3BDuyn%2C+Jeff+H&rft.aulast=Qin&rft.aufirst=Lei&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measuring NAA Synthesis In Vivo Using Proton MRS T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40936068; 4856409 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Xu, Su AU - Yang, Jun AU - Shen, Jun Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Protons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40936068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Measuring+NAA+Synthesis+In+Vivo+Using+Proton+MRS&rft.au=Xu%2C+Su%3BYang%2C+Jun%3BShen%2C+Jun&rft.aulast=Xu&rft.aufirst=Su&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detecting Diffuse White Matter Alterations in Healthy Volunteers Using Tissue Specific Imaging: Potential Implications for Cognitive Function T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40936043; 4853429 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Ikonomidou, Vasiliki N AU - Stern, Susan K AU - Gallo, Antonio AU - Evangelou, Iordanis E AU - Ohayon, Joan M AU - Ehrmantraut, Mary AU - Cortese, Irene AU - Frantzis, Constantinos D AU - Mcfarland, Henry F AU - Kane, Robert L AU - Bagnato, Francesca Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Cognitive ability KW - Substantia alba KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40936043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Detecting+Diffuse+White+Matter+Alterations+in+Healthy+Volunteers+Using+Tissue+Specific+Imaging%3A+Potential+Implications+for+Cognitive+Function&rft.au=Ikonomidou%2C+Vasiliki+N%3BStern%2C+Susan+K%3BGallo%2C+Antonio%3BEvangelou%2C+Iordanis+E%3BOhayon%2C+Joan+M%3BEhrmantraut%2C+Mary%3BCortese%2C+Irene%3BFrantzis%2C+Constantinos+D%3BMcfarland%2C+Henry+F%3BKane%2C+Robert+L%3BBagnato%2C+Francesca&rft.aulast=Ikonomidou&rft.aufirst=Vasiliki&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interleaved Dual-Angle Measurements for the Correction of Partial Saturation in 31P MR Spectroscopy T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40935650; 4853064 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Lopez, Orlando AU - Tyler, Damian J AU - Cole, Mark A AU - Carr, Carolyn A AU - Stuckey, Daniel J AU - Lakatta, Edward AU - Clarke, Kieran AU - Spencer, Richard G Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Spectroscopy KW - Magnetic resonance spectroscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40935650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Interleaved+Dual-Angle+Measurements+for+the+Correction+of+Partial+Saturation+in+31P+MR+Spectroscopy&rft.au=Lopez%2C+Orlando%3BTyler%2C+Damian+J%3BCole%2C+Mark+A%3BCarr%2C+Carolyn+A%3BStuckey%2C+Daniel+J%3BLakatta%2C+Edward%3BClarke%2C+Kieran%3BSpencer%2C+Richard+G&rft.aulast=Lopez&rft.aufirst=Orlando&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SENSE Optimized Sixteen Element Receive Array for Cervical Spinal Cord Imaging at 3T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40935539; 4855201 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Bodurka, Jerzy AU - Ledden, Patrick AU - Bandettini, Peter Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Spinal cord KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40935539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=SENSE+Optimized+Sixteen+Element+Receive+Array+for+Cervical+Spinal+Cord+Imaging+at+3T&rft.au=Bodurka%2C+Jerzy%3BLedden%2C+Patrick%3BBandettini%2C+Peter&rft.aulast=Bodurka&rft.aufirst=Jerzy&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Insights into Intravenous Bradykinin Analogue-Mediated Vasomodulation from Dynamic Contrast-Enhanced MRI of RG-2 Rodent Malignant Gliomas T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40935244; 4856081 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Sarin, Hemant AU - Fung, Steve Huntz AU - Kanevsky, Ariel Shaya AU - Sungyoung, Auh AU - Butman, John Alexander Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Glioma KW - Rodents KW - Magnetic resonance imaging KW - Bradykinin KW - Intravenous administration KW - Brain tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40935244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Novel+Insights+into+Intravenous+Bradykinin+Analogue-Mediated+Vasomodulation+from+Dynamic+Contrast-Enhanced+MRI+of+RG-2+Rodent+Malignant+Gliomas&rft.au=Sarin%2C+Hemant%3BFung%2C+Steve+Huntz%3BKanevsky%2C+Ariel+Shaya%3BSungyoung%2C+Auh%3BButman%2C+John+Alexander&rft.aulast=Sarin&rft.aufirst=Hemant&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post-Processing Correction for Extended Data Acquisition in Whole Brain 3D Quantitative PULSAR Imaging T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40935083; 4853233 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Gai, Neville Dali AU - Butman, John Anthony Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain KW - Neuroimaging KW - Data acquisition KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40935083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Post-Processing+Correction+for+Extended+Data+Acquisition+in+Whole+Brain+3D+Quantitative+PULSAR+Imaging&rft.au=Gai%2C+Neville+Dali%3BButman%2C+John+Anthony&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tagging Efficiency Improvement Using Velocity-Matched Pseudo-Continuous Arterial Spin Labeling and VERSE T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40935036; 4853226 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Luh, Wen-Ming AU - Wong, Eric C AU - Talagala, S Lalith AU - Bandettini, Peter A Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Tagging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40935036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Tagging+Efficiency+Improvement+Using+Velocity-Matched+Pseudo-Continuous+Arterial+Spin+Labeling+and+VERSE&rft.au=Luh%2C+Wen-Ming%3BWong%2C+Eric+C%3BTalagala%2C+S+Lalith%3BBandettini%2C+Peter+A&rft.aulast=Luh&rft.aufirst=Wen-Ming&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Quantitative Perfusion 3D IR-PULSAR with Multi-Slice 2D and Single Slice Imaging T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40934862; 4853234 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Gai, Neville Dali AU - Talagala, Sardha Lalith AU - Butman, John Anthony Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Perfusion KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40934862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Comparison+of+Quantitative+Perfusion+3D+IR-PULSAR+with+Multi-Slice+2D+and+Single+Slice+Imaging&rft.au=Gai%2C+Neville+Dali%3BTalagala%2C+Sardha+Lalith%3BButman%2C+John+Anthony&rft.aulast=Gai&rft.aufirst=Neville&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Resolution R2 Maps Reveal Laminar Structure of Human Visual Cortex In Vivo. T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40934857; 4856508 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Fukunaga, Masaki AU - Bianciardi, Marta AU - van Gelderen, Peter AU - de Zwart, Jacco A AU - Duyn, Jeff H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain mapping KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40934857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=High+Resolution+R2+Maps+Reveal+Laminar+Structure+of+Human+Visual+Cortex+In+Vivo.&rft.au=Fukunaga%2C+Masaki%3BBianciardi%2C+Marta%3Bvan+Gelderen%2C+Peter%3Bde+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Fukunaga&rft.aufirst=Masaki&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spontaneous Activity in the Visual Cortex Persists during Visual Stimulation: A 7T Study T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40934797; 4856377 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Bianciardi, Marta AU - Fukunaga, Masaki AU - van Gelderen, Peter AU - Horovitz, Silvina AU - de Zwart, Jacco AU - Duyn, Jeff Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Visual stimuli KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40934797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Spontaneous+Activity+in+the+Visual+Cortex+Persists+during+Visual+Stimulation%3A+A+7T+Study&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3Bvan+Gelderen%2C+Peter%3BHorovitz%2C+Silvina%3Bde+Zwart%2C+Jacco%3BDuyn%2C+Jeff&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Magnetization-Prepared Segmented FLASH Sequences for High-Field Anatomical Brain Imaging in Animals T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40934711; 4856441 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Bock, Nicholas Adam AU - Ye, Frank AU - Silva, Afonso C Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain KW - Neuroimaging KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40934711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Magnetization-Prepared+Segmented+FLASH+Sequences+for+High-Field+Anatomical+Brain+Imaging+in+Animals&rft.au=Bock%2C+Nicholas+Adam%3BYe%2C+Frank%3BSilva%2C+Afonso+C&rft.aulast=Bock&rft.aufirst=Nicholas&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Resolution Human Brain Susceptibility Maps Calculated from 7 Tesla MRI Phase Data T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40934516; 4856272 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Shmueli, Karin AU - van Gelderen, Peter AU - Li, Tie-Qiang AU - Duyn, Jeff H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain mapping KW - Magnetic resonance imaging KW - Gene mapping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40934516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=High+Resolution+Human+Brain+Susceptibility+Maps+Calculated+from+7+Tesla+MRI+Phase+Data&rft.au=Shmueli%2C+Karin%3Bvan+Gelderen%2C+Peter%3BLi%2C+Tie-Qiang%3BDuyn%2C+Jeff+H&rft.aulast=Shmueli&rft.aufirst=Karin&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo T@@d1r@-Weighted MR Imaging of Rat Brain Using a Surface Coil at 11.7 Tesla T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40933323; 4852963 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Xu, Su AU - Yang, Jehoon AU - Shen, Jun Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain KW - Neuroimaging KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40933323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=In+Vivo+T%40%40d1r%40-Weighted+MR+Imaging+of+Rat+Brain+Using+a+Surface+Coil+at+11.7+Tesla&rft.au=Xu%2C+Su%3BYang%2C+Jehoon%3BShen%2C+Jun&rft.aulast=Xu&rft.aufirst=Su&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SAR Evaluation of 7.0 Tesla Perfusion Imaging with Arterial Spin Labeling Coil T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40933137; 4853784 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Wang, Shumin AU - Merkle, Hellmut AU - Talagala, Lalith Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Perfusion KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40933137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=SAR+Evaluation+of+7.0+Tesla+Perfusion+Imaging+with+Arterial+Spin+Labeling+Coil&rft.au=Wang%2C+Shumin%3BMerkle%2C+Hellmut%3BTalagala%2C+Lalith&rft.aulast=Wang&rft.aufirst=Shumin&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiparametric MRI Characterization of Degradation in Bovine Nasal Cartilage T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40932883; 4855965 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Lin, Ping-Chang AU - Fishbein, Kenneth W AU - Spencer, Richard G Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Magnetic resonance imaging KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40932883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Multiparametric+MRI+Characterization+of+Degradation+in+Bovine+Nasal+Cartilage&rft.au=Lin%2C+Ping-Chang%3BFishbein%2C+Kenneth+W%3BSpencer%2C+Richard+G&rft.aulast=Lin&rft.aufirst=Ping-Chang&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Representation of the NIH Stroke Scale with Probabilistic Diffusion Weighted Imaging Lesion Atlas T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40932663; 4855900 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Singleton, Kyle W AU - Schaewe, Timothy J AU - Boscardin, W John AU - Luby, Marie AU - Warach, Steven AU - Kidwell, Chelsea S AU - Alger, Jeffry R Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Lesions KW - Diffusion KW - Stroke KW - Imaging techniques KW - Atlases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40932663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Representation+of+the+NIH+Stroke+Scale+with+Probabilistic+Diffusion+Weighted+Imaging+Lesion+Atlas&rft.au=Singleton%2C+Kyle+W%3BSchaewe%2C+Timothy+J%3BBoscardin%2C+W+John%3BLuby%2C+Marie%3BWarach%2C+Steven%3BKidwell%2C+Chelsea+S%3BAlger%2C+Jeffry+R&rft.aulast=Singleton&rft.aufirst=Kyle&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatial Heterogeneity of Carotid Artery Wall Strain Using Displacement-Encoded MRI at 1.5T and 3.0T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40932659; 4856155 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Lin, Alexander Peter AU - Wisk, Lauren AU - Bennett, Eric AU - Fraser, Scott AU - Wen, Han Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Magnetic resonance imaging KW - Carotid artery KW - Spatial heterogeneity KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40932659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Spatial+Heterogeneity+of+Carotid+Artery+Wall+Strain+Using+Displacement-Encoded+MRI+at+1.5T+and+3.0T&rft.au=Lin%2C+Alexander+Peter%3BWisk%2C+Lauren%3BBennett%2C+Eric%3BFraser%2C+Scott%3BWen%2C+Han&rft.aulast=Lin&rft.aufirst=Alexander&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Long to Tag? Optimal Tag Duration for Arterial Spin Labeling at 1.5T, 3T, and 7T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40932387; 4855825 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Luh, Wen-Ming AU - Wong, Eric C AU - Bandettini, Peter A Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Perfusion KW - Spin labelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40932387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=How+Long+to+Tag%3F+Optimal+Tag+Duration+for+Arterial+Spin+Labeling+at+1.5T%2C+3T%2C+and+7T&rft.au=Luh%2C+Wen-Ming%3BWong%2C+Eric+C%3BBandettini%2C+Peter+A&rft.aulast=Luh&rft.aufirst=Wen-Ming&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolic Changes in Rat Frontal Cortex after Injection of Pentylenetetrazole Measured by Proton MR Spectroscopy at 9.4T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40932336; 4855754 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Yang, Shaolin AU - Vaupel, D Bruce AU - Lu, Hanbing AU - Ross, Thomas J AU - Rea, William AU - Demny, Steven M AU - Stein, Elliot A AU - Yang, Yihong Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Spectroscopy KW - Pentylenetetrazole KW - Protons KW - Cortex (frontal) KW - Magnetic resonance spectroscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40932336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Metabolic+Changes+in+Rat+Frontal+Cortex+after+Injection+of+Pentylenetetrazole+Measured+by+Proton+MR+Spectroscopy+at+9.4T&rft.au=Yang%2C+Shaolin%3BVaupel%2C+D+Bruce%3BLu%2C+Hanbing%3BRoss%2C+Thomas+J%3BRea%2C+William%3BDemny%2C+Steven+M%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Yang&rft.aufirst=Shaolin&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simple Harmonic Oscillator Based Estimation and Reconstruction for One-Dimensional Q-Space MR T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40932017; 4855684 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Ozarslan, Evren AU - Koay, Cheng Guan AU - Basser, Peter J Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Oscillators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40932017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Simple+Harmonic+Oscillator+Based+Estimation+and+Reconstruction+for+One-Dimensional+Q-Space+MR&rft.au=Ozarslan%2C+Evren%3BKoay%2C+Cheng+Guan%3BBasser%2C+Peter+J&rft.aulast=Ozarslan&rft.aufirst=Evren&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Frequency Specificity of Functional Connectivity in Brain Networks T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40931477; 4855535 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Wu, Changwei Wesley AU - Gu, Hong AU - Lu, Hanbing AU - Chen, Jyh-Horng AU - Stein, Elliot AU - Yang, Yihong Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain KW - Neural networks KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40931477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Frequency+Specificity+of+Functional+Connectivity+in+Brain+Networks&rft.au=Wu%2C+Changwei+Wesley%3BGu%2C+Hong%3BLu%2C+Hanbing%3BChen%2C+Jyh-Horng%3BStein%2C+Elliot%3BYang%2C+Yihong&rft.aulast=Wu&rft.aufirst=Changwei&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temporal Changes in the T1 and T2 Relaxation Rates (dR1 and dR2) in the Rat Brain are Consistent with the Tissue-Clearance Rates of Elemental Manganese T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40931396; 4856164 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Chuang, Kai-Hsiang AU - Koretsky, Alan P AU - Sotak, Christopher H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain KW - Manganese KW - Temporal variations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40931396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Temporal+Changes+in+the+T1+and+T2+Relaxation+Rates+%28dR1+and+dR2%29+in+the+Rat+Brain+are+Consistent+with+the+Tissue-Clearance+Rates+of+Elemental+Manganese&rft.au=Chuang%2C+Kai-Hsiang%3BKoretsky%2C+Alan+P%3BSotak%2C+Christopher+H&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microfabricated Magnetic Structures for Multi-Spectral Contrast T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40930897; 4855669 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Zabow, Gary AU - Dodd, Stephen AU - Moreland, John AU - Koretsky, Alan Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40930897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Microfabricated+Magnetic+Structures+for+Multi-Spectral+Contrast&rft.au=Zabow%2C+Gary%3BDodd%2C+Stephen%3BMoreland%2C+John%3BKoretsky%2C+Alan&rft.aulast=Zabow&rft.aufirst=Gary&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coil Geometry Optimization for Better SNR and Decoupling T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40930792; 4856075 DE: JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Nascimento, George Carlos do AU - Wang, Shumin Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40930792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Coil+Geometry+Optimization+for+Better+SNR+and+Decoupling&rft.au=Nascimento%2C+George+Carlos+do%3BWang%2C+Shumin&rft.aulast=Nascimento&rft.aufirst=George+Carlos&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Resolving Multiple T@@d2@ Compartments in Cartilage with MRI T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40930767; 4855578 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Reiter, David A AU - Lin, Ping-Chang AU - Fishbein, Kenneth W AU - Spencer, Richard G Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Magnetic resonance imaging KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40930767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Resolving+Multiple+T%40%40d2%40+Compartments+in+Cartilage+with+MRI&rft.au=Reiter%2C+David+A%3BLin%2C+Ping-Chang%3BFishbein%2C+Kenneth+W%3BSpencer%2C+Richard+G&rft.aulast=Reiter&rft.aufirst=David&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional Heterogeneity in Vascular Response to Respiratory Challenges as Measured with BOLD FMR T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40930551; 4855509 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Bright, Molly Gallogly AU - Horovitz, Silvina G AU - Jezzard, Peter AU - Duyn, Jeff H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Vascular system KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40930551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Regional+Heterogeneity+in+Vascular+Response+to+Respiratory+Challenges+as+Measured+with+BOLD+FMR&rft.au=Bright%2C+Molly+Gallogly%3BHorovitz%2C+Silvina+G%3BJezzard%2C+Peter%3BDuyn%2C+Jeff+H&rft.aulast=Bright&rft.aufirst=Molly&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Respiration Variations on Independent Component Analysis of Resting State Functional Connectivity T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40930423; 4855516 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Birn, Rasmus Matthias AU - Murphy, Kevin AU - Bandettini, Peter Anthony Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Respiration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40930423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=The+Effect+of+Respiration+Variations+on+Independent+Component+Analysis+of+Resting+State+Functional+Connectivity&rft.au=Birn%2C+Rasmus+Matthias%3BMurphy%2C+Kevin%3BBandettini%2C+Peter+Anthony&rft.aulast=Birn&rft.aufirst=Rasmus&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cortical Architecture of the Human Hippocampus T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40930328; 4855453 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Li, Tie-Qiang AU - Yao, Bing AU - van Gelderen, Peter AU - Merkle, Hellmut AU - Koresky, Alan AU - Duyn, Jeff Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Cortex KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40930328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Cortical+Architecture+of+the+Human+Hippocampus&rft.au=Li%2C+Tie-Qiang%3BYao%2C+Bing%3Bvan+Gelderen%2C+Peter%3BMerkle%2C+Hellmut%3BKoresky%2C+Alan%3BDuyn%2C+Jeff&rft.aulast=Li&rft.aufirst=Tie-Qiang&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolic Imprint of EEG Slow Oscillations as Observed by BOLD-fMRI during Deep Sleep T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40930034; 4856045 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Horovitz, Silvina G AU - Fukunaga, Masaki AU - Picchioni, Dante AU - Carr, Walter S AU - de Zwart, Jacco A AU - Balkin, Thomas J AU - Braun, Allen AU - Duyn, Jeff H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Sleep KW - Oscillations KW - EEG KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40930034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Metabolic+Imprint+of+EEG+Slow+Oscillations+as+Observed+by+BOLD-fMRI+during+Deep+Sleep&rft.au=Horovitz%2C+Silvina+G%3BFukunaga%2C+Masaki%3BPicchioni%2C+Dante%3BCarr%2C+Walter+S%3Bde+Zwart%2C+Jacco+A%3BBalkin%2C+Thomas+J%3BBraun%2C+Allen%3BDuyn%2C+Jeff+H&rft.aulast=Horovitz&rft.aufirst=Silvina&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Diffusion Tensor Imaging and T1 Relaxometry in Niemann-Pick C Disease T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40929870; 4855422 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Lee, Christabel E.C. AU - Thomasson, David M AU - Yanjanin, Nicole M AU - Baker, Eva H AU - Porter, Forbes D Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Diffusion KW - Magnetic resonance imaging KW - Niemann-Pick disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40929870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Quantitative+Diffusion+Tensor+Imaging+and+T1+Relaxometry+in+Niemann-Pick+C+Disease&rft.au=Lee%2C+Christabel+E.C.%3BThomasson%2C+David+M%3BYanjanin%2C+Nicole+M%3BBaker%2C+Eva+H%3BPorter%2C+Forbes+D&rft.aulast=Lee&rft.aufirst=Christabel&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduction of Flow Artifacts in Balanced SSFP Imaging Using S5FP T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40929807; 4855850 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Derbyshire, J Andrew AU - Guttman, Michael A AU - Lederman, Robert J AU - McVeigh, Elliot R Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Artifacts KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40929807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Reduction+of+Flow+Artifacts+in+Balanced+SSFP+Imaging+Using+S5FP&rft.au=Derbyshire%2C+J+Andrew%3BGuttman%2C+Michael+A%3BLederman%2C+Robert+J%3BMcVeigh%2C+Elliot+R&rft.aulast=Derbyshire&rft.aufirst=J&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Oxygenation Status and Tumor Metabolites. Noninvasive Evidence for Aerobic Glycolysis (Warburg Effect) in Tumor by Sequential EPR Oxymetric Imaging and MRS T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40929692; 4855367 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Matsumoto, Shingo AU - Hyodo, Fuminori AU - Munasinghe, Jeeva AU - Batra, Sonny AU - Suburamanian, Sankaran AU - Devasahayam, Nallathamby AU - Mitchell, James B AU - Krishna, Murali C Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Oxygenation KW - Metabolites KW - Tumors KW - Imaging techniques KW - Glycolysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40929692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Relationship+between+Oxygenation+Status+and+Tumor+Metabolites.+Noninvasive+Evidence+for+Aerobic+Glycolysis+%28Warburg+Effect%29+in+Tumor+by+Sequential+EPR+Oxymetric+Imaging+and+MRS&rft.au=Matsumoto%2C+Shingo%3BHyodo%2C+Fuminori%3BMunasinghe%2C+Jeeva%3BBatra%2C+Sonny%3BSuburamanian%2C+Sankaran%3BDevasahayam%2C+Nallathamby%3BMitchell%2C+James+B%3BKrishna%2C+Murali+C&rft.aulast=Matsumoto&rft.aufirst=Shingo&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Elliptical Cone of Uncertainty in Diffusion Tensor Imaging and its Normalized Measures T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40929359; 4854474 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Koay, Cheng Guan AU - Basser, Peter J Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Diffusion KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40929359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=The+Elliptical+Cone+of+Uncertainty+in+Diffusion+Tensor+Imaging+and+its+Normalized+Measures&rft.au=Koay%2C+Cheng+Guan%3BBasser%2C+Peter+J&rft.aulast=Koay&rft.aufirst=Cheng&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Continuous Arterial Spin Labeling Perfusion MRI at 7T and 3T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40929113; 4855393 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Talagala, S Lalith AU - Li, T-Q AU - Merkle, H AU - Wang, S AU - Bodurka, J AU - van Gelderen, P AU - Duyn, J Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Magnetic resonance imaging KW - Perfusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40929113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Comparison+of+Continuous+Arterial+Spin+Labeling+Perfusion+MRI+at+7T+and+3T&rft.au=Talagala%2C+S+Lalith%3BLi%2C+T-Q%3BMerkle%2C+H%3BWang%2C+S%3BBodurka%2C+J%3Bvan+Gelderen%2C+P%3BDuyn%2C+J&rft.aulast=Talagala&rft.aufirst=S&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does Prussian Blue Staining Correlate with Dextran Staining of Ferumoxides Labeled Cells? T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40928898; 4855344 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Chaudhry, Aneeka AU - Frank, Joseph A AU - Pawelczyk, Edyta Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Dextran KW - Staining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40928898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Does+Prussian+Blue+Staining+Correlate+with+Dextran+Staining+of+Ferumoxides+Labeled+Cells%3F&rft.au=Chaudhry%2C+Aneeka%3BFrank%2C+Joseph+A%3BPawelczyk%2C+Edyta&rft.aulast=Chaudhry&rft.aufirst=Aneeka&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Tracking of Magnetically Labeled Breast Cancer Cells in Rat Brain with a Fast T2 Mapping Technique T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40928687; 4855817 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Liu, Wei AU - Senegas, Julien AU - Song, Ho-Taek AU - Jordan, E Kay AU - Dahnke, Hannes AU - Frank, Joseph A Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain mapping KW - Breast cancer KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40928687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Quantitative+Tracking+of+Magnetically+Labeled+Breast+Cancer+Cells+in+Rat+Brain+with+a+Fast+T2+Mapping+Technique&rft.au=Liu%2C+Wei%3BSenegas%2C+Julien%3BSong%2C+Ho-Taek%3BJordan%2C+E+Kay%3BDahnke%2C+Hannes%3BFrank%2C+Joseph+A&rft.aulast=Liu&rft.aufirst=Wei&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging Cardiac Motion and Flow Simultaneously during Exercise Stress Studies Using SPAMM N' EGGS T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40928675; 4852797 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Sampath, Smita AU - Derbyshire, John Andrew AU - Ledesma-Carbayo, Maria J AU - McVeigh, Elliot R Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Stress KW - Eggs KW - Imaging techniques KW - Heart KW - Physical training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40928675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Imaging+Cardiac+Motion+and+Flow+Simultaneously+during+Exercise+Stress+Studies+Using+SPAMM+N%27+EGGS&rft.au=Sampath%2C+Smita%3BDerbyshire%2C+John+Andrew%3BLedesma-Carbayo%2C+Maria+J%3BMcVeigh%2C+Elliot+R&rft.aulast=Sampath&rft.aufirst=Smita&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cardiac Function in Post-Cardiac Arrest Mice by MRI and Effect of Nitrite Treatment T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40928618; 4854270 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Anderson, Stasia Ann AU - Dezfulian, Cameron AU - Alekseyenko, Aleksey AU - Gladwin, Mark T Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Arrests KW - Nitrite KW - Mice KW - Magnetic resonance imaging KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40928618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Cardiac+Function+in+Post-Cardiac+Arrest+Mice+by+MRI+and+Effect+of+Nitrite+Treatment&rft.au=Anderson%2C+Stasia+Ann%3BDezfulian%2C+Cameron%3BAlekseyenko%2C+Aleksey%3BGladwin%2C+Mark+T&rft.aulast=Anderson&rft.aufirst=Stasia&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Saturation-Band Cine MRI Improves Detection of Intracardiac Shunt T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40928180; 4852802 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Bandettini, Wiphada Patricia AU - Arai, Andrew Ernest Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Shunts KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40928180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Saturation-Band+Cine+MRI+Improves+Detection+of+Intracardiac+Shunt&rft.au=Bandettini%2C+Wiphada+Patricia%3BArai%2C+Andrew+Ernest&rft.aulast=Bandettini&rft.aufirst=Wiphada&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Correlated Noise Suppression Method Substantially Improves Detection of fMRI Response to Weak Stimuli at 7 T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40928122; 4854630 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Bianciardi, Marta AU - Fukunaga, Masaki AU - Duyn, Jeff H AU - van Gelderen, Peter AU - de Zwart, Jacco A Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Noise levels KW - Functional magnetic resonance imaging KW - Noise reduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40928122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Novel+Correlated+Noise+Suppression+Method+Substantially+Improves+Detection+of+fMRI+Response+to+Weak+Stimuli+at+7+T&rft.au=Bianciardi%2C+Marta%3BFukunaga%2C+Masaki%3BDuyn%2C+Jeff+H%3Bvan+Gelderen%2C+Peter%3Bde+Zwart%2C+Jacco+A&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Upper Bound Estimation of Neuronal Current-Induced Magnetic Field Changes in Humans T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40928077; 4854628 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Murphy, Kevin AU - Bodurka, Jerzy AU - Bandettini, Peter Anthony Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Magnetic fields KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40928077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Upper+Bound+Estimation+of+Neuronal+Current-Induced+Magnetic+Field+Changes+in+Humans&rft.au=Murphy%2C+Kevin%3BBodurka%2C+Jerzy%3BBandettini%2C+Peter+Anthony&rft.aulast=Murphy&rft.aufirst=Kevin&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hyperpolarized @@u3@He MR Imaging of Ventilation after Bacterial Lipopolysaccharide Exposure in Mice: A Model for Image-Guided Sampling of Ventilation Defects T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927704; 4854211 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Thomas, Abraham AU - Voltz, James AU - Fubara, Boma AU - Zeldin, Darryl AU - Driehuys, Bastiaan Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Ventilation KW - Mice KW - Magnetic resonance imaging KW - Sampling KW - Lipopolysaccharides KW - Defects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Hyperpolarized+%40%40u3%40He+MR+Imaging+of+Ventilation+after+Bacterial+Lipopolysaccharide+Exposure+in+Mice%3A+A+Model+for+Image-Guided+Sampling+of+Ventilation+Defects&rft.au=Thomas%2C+Abraham%3BVoltz%2C+James%3BFubara%2C+Boma%3BZeldin%2C+Darryl%3BDriehuys%2C+Bastiaan&rft.aulast=Thomas&rft.aufirst=Abraham&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain Redox Imaging Using Blood Brain Barrier Permeable Nitroxide MRI Contrast Agent T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927688; 4855038 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Hyodo, Fuminori AU - Chuang, Kai-Hsiang AU - Goloshevsky, Artem G AU - Matsumoto, Shingo AU - Mitchell, James B AU - Koretsky, Alan P AU - Krishna, Murali C Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain KW - Neuroimaging KW - Magnetic resonance imaging KW - Contrast media KW - Nitroxide KW - Blood-brain barrier KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Brain+Redox+Imaging+Using+Blood+Brain+Barrier+Permeable+Nitroxide+MRI+Contrast+Agent&rft.au=Hyodo%2C+Fuminori%3BChuang%2C+Kai-Hsiang%3BGoloshevsky%2C+Artem+G%3BMatsumoto%2C+Shingo%3BMitchell%2C+James+B%3BKoretsky%2C+Alan+P%3BKrishna%2C+Murali+C&rft.aulast=Hyodo&rft.aufirst=Fuminori&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of CBV and Capillary Permeability on ASL Signal T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927608; 4855397 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Wu, Changwei Wesley AU - Chen, Jyh-Horng AU - Yang, Yihong Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Membrane permeability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Effects+of+CBV+and+Capillary+Permeability+on+ASL+Signal&rft.au=Wu%2C+Changwei+Wesley%3BChen%2C+Jyh-Horng%3BYang%2C+Yihong&rft.aulast=Wu&rft.aufirst=Changwei&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - B1 Transmit Field Correction at 7T Using Coupled Inner Elements T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927564; 4854730 DE: JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Merkle, Hellmut AU - Wang, Shumin AU - van Gelderen, Peter AU - Li, Tie Q AU - Murphy-Boesch, Joseph AU - Koretsky, Alan P AU - Duyn, Jeff H Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=B1+Transmit+Field+Correction+at+7T+Using+Coupled+Inner+Elements&rft.au=Merkle%2C+Hellmut%3BWang%2C+Shumin%3Bvan+Gelderen%2C+Peter%3BLi%2C+Tie+Q%3BMurphy-Boesch%2C+Joseph%3BKoretsky%2C+Alan+P%3BDuyn%2C+Jeff+H&rft.aulast=Merkle&rft.aufirst=Hellmut&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible Sources of Functional Connectivity and Under-Connectivity in Adolescents with Autism Spectrum Disorders T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927521; 4854957 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Jones, Tyler Bridgeland AU - Kenworthy, Lauren AU - Case, Laura K AU - Milleville, Shawn C AU - Bandettini, Peter Anthony AU - Martin, Alex AU - Birn, Rasmus Matthias Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Adolescents KW - Autism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Possible+Sources+of+Functional+Connectivity+and+Under-Connectivity+in+Adolescents+with+Autism+Spectrum+Disorders&rft.au=Jones%2C+Tyler+Bridgeland%3BKenworthy%2C+Lauren%3BCase%2C+Laura+K%3BMilleville%2C+Shawn+C%3BBandettini%2C+Peter+Anthony%3BMartin%2C+Alex%3BBirn%2C+Rasmus+Matthias&rft.aulast=Jones&rft.aufirst=Tyler&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping Plasticity in the Forepaw Digit Barrel Subfield of Rat Brain Using Functional MRI T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927490; 4854139 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Weng, Jun-Cheng AU - Chuang, Kai-Hsiang AU - Goloshevsky, Artem AU - Dodd, Stephen AU - Chen, Jyh-Horng AU - Koretsky, Alan P Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain mapping KW - Functional magnetic resonance imaging KW - Plasticity (functional) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Mapping+Plasticity+in+the+Forepaw+Digit+Barrel+Subfield+of+Rat+Brain+Using+Functional+MRI&rft.au=Weng%2C+Jun-Cheng%3BChuang%2C+Kai-Hsiang%3BGoloshevsky%2C+Artem%3BDodd%2C+Stephen%3BChen%2C+Jyh-Horng%3BKoretsky%2C+Alan+P&rft.aulast=Weng&rft.aufirst=Jun-Cheng&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessment of Functional Cortical Plasticity with Bold fMRI Mapping of Adjacent Somatosensory Representations in Rat T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927371; 4854140 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Goloshevsky, Artem G AU - Dodd, Stephen J AU - Koretsky, Alan P Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Mapping KW - Plasticity (functional) KW - Functional magnetic resonance imaging KW - Cortex KW - Plasticity (cortical) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Assessment+of+Functional+Cortical+Plasticity+with+Bold+fMRI+Mapping+of+Adjacent+Somatosensory+Representations+in+Rat&rft.au=Goloshevsky%2C+Artem+G%3BDodd%2C+Stephen+J%3BKoretsky%2C+Alan+P&rft.aulast=Goloshevsky&rft.aufirst=Artem&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Inductively Decoupled Coil Array for Parallel Imaging of Small Animals at 7T T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927368; 4854288 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Nascimento, George Carlos do AU - Paiva, Fernando Fernandes AU - Silva, Afonso C Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=An+Inductively+Decoupled+Coil+Array+for+Parallel+Imaging+of+Small+Animals+at+7T&rft.au=Nascimento%2C+George+Carlos+do%3BPaiva%2C+Fernando+Fernandes%3BSilva%2C+Afonso+C&rft.aulast=Nascimento&rft.aufirst=George+Carlos&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxymetric Imaging in EPR: Single Point Imaging Versus Two-Pulse Echo Imaging T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40927208; 4855362 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Subramanian, Sankaran AU - Matsumoto, Shingo AU - Batra, Sonny AU - Devasahayam, Nallathamby AU - Hyodo, Fuminori AU - Krishna, Murali C Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40927208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Oxymetric+Imaging+in+EPR%3A+Single+Point+Imaging+Versus+Two-Pulse+Echo+Imaging&rft.au=Subramanian%2C+Sankaran%3BMatsumoto%2C+Shingo%3BBatra%2C+Sonny%3BDevasahayam%2C+Nallathamby%3BHyodo%2C+Fuminori%3BKrishna%2C+Murali+C&rft.aulast=Subramanian&rft.aufirst=Sankaran&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monitoring Tissue Volume Fraction and T@@d1@ Changes during Brain Activation Using a Look-Locker EPI Sequence T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40926674; 4854129 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Shin, Wanyong AU - Gu, Hong AU - Yang, Yihong Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40926674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Monitoring+Tissue+Volume+Fraction+and+T%40%40d1%40+Changes+during+Brain+Activation+Using+a+Look-Locker+EPI+Sequence&rft.au=Shin%2C+Wanyong%3BGu%2C+Hong%3BYang%2C+Yihong&rft.aulast=Shin&rft.aufirst=Wanyong&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatial and Temporal Characteristics of the fMRI Response to Brief Somatosensory Stimulation in Rats T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40925615; 4855045 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Hirano, Yoshiyuki AU - Stefanovic, Bojana AU - Nascimento, George C AU - Silva, Afonso C Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Rats KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40925615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Spatial+and+Temporal+Characteristics+of+the+fMRI+Response+to+Brief+Somatosensory+Stimulation+in+Rats&rft.au=Hirano%2C+Yoshiyuki%3BStefanovic%2C+Bojana%3BNascimento%2C+George+C%3BSilva%2C+Afonso+C&rft.aulast=Hirano&rft.aufirst=Yoshiyuki&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Thalamocortical Inputs of the Rat Whisker Barrel Field Using Manganese Enhanced MRI T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40925351; 4854104 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Tucciarone, Jason AU - Koretsky, Alan Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Manganese KW - Magnetic resonance imaging KW - Cortex KW - Thalamus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40925351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Detection+of+Thalamocortical+Inputs+of+the+Rat+Whisker+Barrel+Field+Using+Manganese+Enhanced+MRI&rft.au=Tucciarone%2C+Jason%3BKoretsky%2C+Alan&rft.aulast=Tucciarone&rft.aufirst=Jason&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Delayed Enhancement of the Peri-Infarct Border Zone is Significantly Affected by Partial Volume Averaging: Insights from Ex Vivo Rat Heart Images at a Near-Cellular Resolution T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40924236; 4852839 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Hsu, Li-Yueh AU - Schelbert, Erik B AU - Anderson, Stasia A AU - Mohanty, Bibhu D AU - Karim, Syed M AU - Kellman, Peter AU - Aletras, Anthony H AU - Arai, Andrew E Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40924236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Delayed+Enhancement+of+the+Peri-Infarct+Border+Zone+is+Significantly+Affected+by+Partial+Volume+Averaging%3A+Insights+from+Ex+Vivo+Rat+Heart+Images+at+a+Near-Cellular+Resolution&rft.au=Hsu%2C+Li-Yueh%3BSchelbert%2C+Erik+B%3BAnderson%2C+Stasia+A%3BMohanty%2C+Bibhu+D%3BKarim%2C+Syed+M%3BKellman%2C+Peter%3BAletras%2C+Anthony+H%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of EPI Distortion Correction Methods in Diffusion Tensor MRI T2 - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AN - 40922788; 4854002 JF - 16th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2008) AU - Wu, Minjie AU - Barnett, Alan S AU - Marenco, Stefano AU - Walker, Lindsay AU - Lemaitre, Herve AU - Pierpaoli, Carlo Y1 - 2008/05/03/ PY - 2008 DA - 2008 May 03 KW - Diffusion KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40922788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.atitle=Comparison+of+EPI+Distortion+Correction+Methods+in+Diffusion+Tensor+MRI&rft.au=Wu%2C+Minjie%3BBarnett%2C+Alan+S%3BMarenco%2C+Stefano%3BWalker%2C+Lindsay%3BLemaitre%2C+Herve%3BPierpaoli%2C+Carlo&rft.aulast=Wu&rft.aufirst=Minjie&rft.date=2008-05-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/08/08program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Initial Location of the RNA-dependent RNA Polymerase in the Bacteriophage Phi 6 Procapsid Determined by Cryo-electron Microscopy AN - 20930744; 8199860 AB - The RNA-dependent RNA polymerases (RdRPs) of Cystoviridae bacteriophages, like those of eukaryotic viruses of the Reoviridae, function inside the inner capsid shell in both replication and transcription. In bacteriophage Phi 6, this inner shell is first assembled as an icosahedral procapsid with recessed 5-fold vertices that subsequently undergoes major structural changes during maturation. The tripartite genome is packaged as single-stranded RNA molecules via channels on the 5-fold vertices, and transcripts probably exit the mature capsid by the same route. The RdRP (protein P2) is assembled within the procapsid, and it was thought that it should be located on the 5-fold axes near the RNA entry and exit channels. To determine the initial location of the RdRP inside the procapsid of bacteriophage Phi 6, we performed cryo-electron microscopy of wild type and mutant procapsids and complemented these data with biochemical determinations of copy numbers. We observe ring-like densities on the 3-fold axes that are strong in a mutant that has similar to 10 copies of P2 per particle; faint in wild type, reflecting the lower copy number of similar to 3; and completely absent in a P2-null mutant. The dimensions and shapes of these densities match those of the known crystal structure of the P2 monomer. We propose that, during maturation, the P2 molecules rotate to occupy positions closer to adjacent 5-fold vertices where they conduct replication and transcription. JF - Journal of Biological Chemistry AU - Sen, Anindito AU - Heymann, JBernard AU - Cheng, Naiqian AU - Qiao, Jian AU - Mindich, Leonard AU - Steven, Alasdair C AD - Laboratory of Structural Biology Research, NIAMS, National Institutes of Health, Bethesda, Maryland 20892 and the Department of Microbiology, The Public Health Research Institute Center, New Jersey Medical School, University of Medicine & Dentistry of New Jersey, Newark, New Jersey 07103 Y1 - 2008/05/02/ PY - 2008 DA - 2008 May 02 SP - 12227 EP - 12231 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 18 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Capsids KW - Bacteria KW - Reoviridae KW - Replication KW - Procapsids KW - Transcription KW - Crystals KW - copy number KW - Monomers KW - DNA-directed RNA polymerase KW - RNA-directed RNA polymerase KW - Microscopy KW - Cystoviridae KW - Shells KW - A 01490:Miscellaneous KW - N 14830:RNA KW - J 02430:Symbiosis, Antibiosis & Phages KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20930744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Initial+Location+of+the+RNA-dependent+RNA+Polymerase+in+the+Bacteriophage+Phi+6+Procapsid+Determined+by+Cryo-electron+Microscopy&rft.au=Sen%2C+Anindito%3BHeymann%2C+JBernard%3BCheng%2C+Naiqian%3BQiao%2C+Jian%3BMindich%2C+Leonard%3BSteven%2C+Alasdair+C&rft.aulast=Sen&rft.aufirst=Anindito&rft.date=2008-05-02&rft.volume=283&rft.issue=18&rft.spage=12227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Monomers; Capsids; Phages; DNA-directed RNA polymerase; Replication; RNA-directed RNA polymerase; Microscopy; Transcription; Procapsids; Crystals; Shells; copy number; Bacteria; Reoviridae; Cystoviridae ER - TY - JOUR T1 - Molecular and Antigenic Characterization of a Streptococcus oralis Coaggregation Receptor Polysaccharide by Carbohydrate Engineering in Streptococcus gordonii AN - 20867038; 8199904 AB - The coaggregation receptor polysaccharides (RPS) of Streptococcus oralis and related species are recognized by lectin-like adhesins on other members of the oral biofilm community and by RPS-specific antibodies. The former interactions involve beta -GalNAc or beta -Gal containing host-like motifs in the oligosaccharide repeating units of these polysaccharides, whereas the latter involves features of these molecules that are immunogenic. In the present investigation, the molecular and corresponding structural basis for the serotype specificity of S. oralis ATCC 10557 RPS was determined by engineering the production of this polysaccharide in transformable Streptococcus gordonii 38. This involved the systematic replacement of genes in the rps cluster of strain 38 with different but related genes from S. oralis 10557 and structural characterization of the resulting polysaccharides. The results identify four unique genes in the rps cluster of strain 10557. These include wefI for an alpha -Gal transferase, wefJ for a GalNAc-1-phosphotransferase that has a unique acceptor specificity, wefK for an acetyl transferase that acts at two positions in the hexasaccharide repeating unit, and a novel wzy associated with the beta 1-3 linkage between these units. The serotype specificity of engineered polysaccharides correlated with the wefI-dependent presence of alpha -Gal in these molecules rather than with partial O-acetylation or with the linkage between repeating units. The findings illustrate a direct approach for defining the molecular basis of polysaccharide structure and antigenicity. JF - Journal of Biological Chemistry AU - Yoshida, Yasuo AU - Yang, Jinghua AU - Peaker, Paule-Esther AU - Kato, Hirohisa AU - Bush, CAllen AU - Cisar, John O AD - Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, the Department of Dental Pharmacology, Iwate Medical University School of Dentistry, Morioka 020-8505, Japan, and the Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland 21250 Y1 - 2008/05/02/ PY - 2008 DA - 2008 May 02 SP - 12654 EP - 12664 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 18 SN - 0021-9258, 0021-9258 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Adhesins KW - Antibodies KW - Serotypes KW - oligosaccharides KW - Streptococcus gordonii KW - Antigenicity KW - Carbohydrates KW - Biofilms KW - Polysaccharides KW - Streptococcus oralis KW - J 02310:Genetics & Taxonomy KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20867038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Molecular+and+Antigenic+Characterization+of+a+Streptococcus+oralis+Coaggregation+Receptor+Polysaccharide+by+Carbohydrate+Engineering+in+Streptococcus+gordonii&rft.au=Yoshida%2C+Yasuo%3BYang%2C+Jinghua%3BPeaker%2C+Paule-Esther%3BKato%2C+Hirohisa%3BBush%2C+CAllen%3BCisar%2C+John+O&rft.aulast=Yoshida&rft.aufirst=Yasuo&rft.date=2008-05-02&rft.volume=283&rft.issue=18&rft.spage=12654&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Adhesins; Antibodies; oligosaccharides; Serotypes; Antigenicity; Biofilms; Carbohydrates; Polysaccharides; Streptococcus gordonii; Streptococcus oralis ER - TY - JOUR T1 - Clinical management of drug interaction with antiretroviral agents. AN - 733326878; 19372985 AB - Combination antiretroviral therapy has improved the morbidity and mortality of HIV-infected patients worldwide. As patients live longer, management of HIV infection extends to treatment of a wide spectrum of co-morbid conditions. Pharmacokinetic interactions are common among antiretroviral drugs when they are used in combination and along with treatments for other conditions. This review discusses the clinical significance of drug interactions among antiretroviral drugs and other medications, resources to use in assessing drug interaction potential, and some key principles to follow when managing patients prescribed potentially interacting drugs. Targeted pharmacokinetic drug interaction studies and extrapolations on the basis of potential mechanism of interactions provide an initial basis for recommendations regarding use of certain drug combinations. Some unexpected interactions have emerged in the literature through case reports in which untoward effects were observed. Management of patients on multiple drug therapy can be a challenge. The key to safe and effective therapy relies on the clinician's vigilance in their ongoing assessment of interaction potential among drugs prescribed to each patient, the significance for such interactions, the need for modification to therapy, and close follow up to assess safety and toxicity. JF - Current opinion in HIV and AIDS AU - Pau, Alice K AD - Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1880, USA. apau@niaid.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 319 EP - 324 VL - 3 IS - 3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733326878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+HIV+and+AIDS&rft.atitle=Clinical+management+of+drug+interaction+with+antiretroviral+agents.&rft.au=Pau%2C+Alice+K&rft.aulast=Pau&rft.aufirst=Alice&rft.date=2008-05-01&rft.volume=3&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+HIV+and+AIDS&rft.issn=1746-6318&rft_id=info:doi/10.1097%2FCOH.0b013e3282f82c06 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-16 N1 - Date created - 2009-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/COH.0b013e3282f82c06 ER - TY - JOUR T1 - Neurologic complications of antitumor antibody therapies. AN - 71680982; 18541121 AB - Antibody-based therapy is being explored across a variety of disease types. Several successes in oncology have become part of standard care for diseases such as colorectal cancer and non-Hodgkin's lymphoma. Traditional chemotherapeutic agents have had significant dose-limiting neurologic toxicities associated with their use. Although there are rare incidences of significant neurologic complications of antibody cancer therapy, these treatments are generally very well tolerated. Because most antibody therapy is adjunctive to other treatments, attribution to the immunologic component is often difficult to discern. JF - Current neurology and neuroscience reports AU - Kreisl, Teri N AD - Neuro-Oncology Branch, National Cancer Institute, 9030 Old Georgetown Road, Bloch Building 82, Room 243, Bethesda, MD 20892, USA. kreislt@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 259 EP - 263 VL - 8 IS - 3 KW - Antibodies, Neoplasm KW - 0 KW - Index Medicus KW - Humans KW - Antibodies, Neoplasm -- adverse effects KW - Nervous System Diseases -- etiology KW - Antibodies, Neoplasm -- therapeutic use KW - Neoplasms -- therapy KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71680982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+neurology+and+neuroscience+reports&rft.atitle=Neurologic+complications+of+antitumor+antibody+therapies.&rft.au=Kreisl%2C+Teri+N&rft.aulast=Kreisl&rft.aufirst=Teri&rft.date=2008-05-01&rft.volume=8&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Current+neurology+and+neuroscience+reports&rft.issn=1534-6293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-18 N1 - Date created - 2008-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase 0 clinical trials: conceptions and misconceptions. AN - 71646481; 18536551 AB - Phase 0 clinical trials, developed in response to the United States Food and Drug Administration (FDA)'s recent exploratory Investigational New Drug (IND) guidance, are intended to expedite the clinical evaluation of new molecular entities. The exploratory IND supports the performance of first-in-human testing of new investigational agents at subtherapeutic doses based on reduced manufacturing and toxicologic requirements, allowing the demonstration of drug-target effects and assessment of pharmacokinetic-pharmacodynamic relationships in humans earlier in clinical development. The objectives of a phase 0 cancer clinical trial are to establish at the very earliest opportunity-before large numbers of patients have been accrued and exposed to potential drug-associated toxicity-whether an agent is modulating its target in a tumor, and consequently whether further clinical development is warranted. We review here the fundamental requirements of clinical studies conducted under an exploratory IND and address some common misconceptions regarding oncologic phase 0 trials. JF - Cancer journal (Sudbury, Mass.) AU - Kummar, Shivaani AU - Rubinstein, Larry AU - Kinders, Robert AU - Parchment, Ralph E AU - Gutierrez, Martin E AU - Murgo, Anthony J AU - Ji, Jay AU - Mroczkowski, Barbara AU - Pickeral, Oxana K AU - Simpson, Mel AU - Hollingshead, Melinda AU - Yang, Sherry X AU - Helman, Lee AU - Wiltrout, Robert AU - Collins, Jerry AU - Tomaszewski, Joseph E AU - Doroshow, James H AD - Center for Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892, USA. PY - 2008 SP - 133 EP - 137 VL - 14 IS - 3 SN - 1528-9117, 1528-9117 KW - Drugs, Investigational KW - 0 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Pharmacology KW - Humans KW - Pharmacokinetics KW - Biomedical Research -- legislation & jurisprudence KW - Biomedical Research -- methods KW - Clinical Trials as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71646481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.atitle=Phase+0+clinical+trials%3A+conceptions+and+misconceptions.&rft.au=Kummar%2C+Shivaani%3BRubinstein%2C+Larry%3BKinders%2C+Robert%3BParchment%2C+Ralph+E%3BGutierrez%2C+Martin+E%3BMurgo%2C+Anthony+J%3BJi%2C+Jay%3BMroczkowski%2C+Barbara%3BPickeral%2C+Oxana+K%3BSimpson%2C+Mel%3BHollingshead%2C+Melinda%3BYang%2C+Sherry+X%3BHelman%2C+Lee%3BWiltrout%2C+Robert%3BCollins%2C+Jerry%3BTomaszewski%2C+Joseph+E%3BDoroshow%2C+James+H&rft.aulast=Kummar&rft.aufirst=Shivaani&rft.date=2008-05-01&rft.volume=14&rft.issue=3&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.issn=15289117&rft_id=info:doi/10.1097%2FPPO.0b013e318172d6f3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/PPO.0b013e318172d6f3 ER - TY - JOUR T1 - MBL2 and hepatitis C virus infection among injection drug users. AN - 71644244; 18452612 AB - Genetic variations in MBL2 that reduce circulating levels and alter functional properties of the mannose binding lectin (MBL) have been associated with many autoimmune and infectious diseases. We examined whether MBL2 variants influence the outcome of hepatitis C virus (HCV) infection. Participants were enrolled in the Urban Health Study of San Francisco Bay area injection drug users (IDU) during 1998 through 2000. Study subjects who had a positive test for HCV antibody were eligible for the current study. Participants who were positive for HCV RNA were frequency matched to those who were negative for HCV RNA on the basis of ethnicity and duration of IDU. Genotyping was performed for 15 single nucleotide polymorphisms in MBL2. Statistical analyses of European American and African American participants were conducted separately. The analysis included 198 study subjects who were positive for HCV antibody, but negative for HCV RNA, and 654 IDUs who were positive for both antibody and virus. There was no significant association between any of the genetic variants that cause MBL deficiency and the presence of HCV RNA. Unexpectedly, the MBL2 -289X promoter genotype, which causes MBL deficiency, was over-represented among European Americans who were HCV RNA negative (OR = 1.65, 95% CI 1.05-2.58), although not among the African Americans. This study found no association between genetic variants that cause MBL deficiency and the presence of HCV RNA. The observation that MBL2 -289X was associated with the absence of HCV RNA in European Americans requires validation. JF - BMC infectious diseases AU - Brown, Elizabeth E AU - Zhang, Mingdong AU - Zarin-Pass, Rebecca AU - Bernig, Toralf AU - Tseng, Fan-Chen AU - Xiao, Nianqing AU - Yeager, Meredith AU - Edlin, Brian R AU - Chanock, Stephen J AU - O'Brien, Thomas R AD - Division of Cancer Epidemiology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. ebrown@ms.soph.uab.edu Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 57 VL - 8 KW - Hepatitis C Antibodies KW - 0 KW - MBL2 protein, human KW - Mannose-Binding Lectin KW - RNA, Viral KW - Index Medicus KW - Polymorphism, Genetic KW - Hepatitis C Antibodies -- blood KW - Humans KW - Aged KW - European Continental Ancestry Group -- genetics KW - Genotype KW - San Francisco KW - Aged, 80 and over KW - Logistic Models KW - Adult KW - Case-Control Studies KW - Middle Aged KW - African Americans -- genetics KW - Female KW - Male KW - RNA, Viral -- analysis KW - Hepacivirus -- immunology KW - Hepacivirus -- genetics KW - Hepacivirus -- isolation & purification KW - Substance Abuse, Intravenous -- complications KW - Hepatitis C -- genetics KW - Mannose-Binding Lectin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71644244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+infectious+diseases&rft.atitle=MBL2+and+hepatitis+C+virus+infection+among+injection+drug+users.&rft.au=Brown%2C+Elizabeth+E%3BZhang%2C+Mingdong%3BZarin-Pass%2C+Rebecca%3BBernig%2C+Toralf%3BTseng%2C+Fan-Chen%3BXiao%2C+Nianqing%3BYeager%2C+Meredith%3BEdlin%2C+Brian+R%3BChanock%2C+Stephen+J%3BO%27Brien%2C+Thomas+R&rft.aulast=Brown&rft.aufirst=Elizabeth&rft.date=2008-05-01&rft.volume=8&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=BMC+infectious+diseases&rft.issn=1471-2334&rft_id=info:doi/10.1186%2F1471-2334-8-57 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-19 N1 - Date created - 2008-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Jul 26;284(4):450-6 [10904508] Lancet. 1996 Nov 23;348(9039):1417-9 [8965590] J Immunol. 1998 Sep 15;161(6):3169-75 [9743385] J Virol. 2005 Jul;79(14):9192-6 [15994813] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Hum Genet. 2005 Dec;118(3-4):404-15 [16208516] Genes Immun. 2006 Mar;7(2):85-94 [16395391] J Infect Dis. 2006 Apr 15;193(8):1054-62 [16544245] Immunol Lett. 2007 Jan 15;108(1):34-44 [17157924] J Viral Hepat. 2008 Sep;15(9):690-8 [18507757] Lancet. 2001 May 5;357(9266):1397-401 [11356437] Hum Genet. 2001 Jul;109(1):121-4 [11479744] MMWR Recomm Rep. 2003 Feb 7;52(RR-3):1-13, 15; quiz CE1-4 [12585742] J Infect Dis. 2003 Sep 1;188(5):777-82 [12934195] Clin Infect Dis. 2003 Dec 1;37(11):1496-505 [14614673] NIH Consens State Sci Statements. 2002 Jun 10-12;19(3):1-46 [14768714] Genes Immun. 2004 Sep;5(6):461-76 [15306844] J Exp Med. 1989 Oct 1;170(4):1175-89 [2477486] Lancet. 1991 Jun 29;337(8757):1569-70 [1675710] Immunogenetics. 1994;40(1):37-44 [8206524] J Immunol. 1995 Sep 15;155(6):3013-20 [7673719] Lancet. 1997 Jan 25;349(9047):236-40 [9014910] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2334-8-57 ER - TY - JOUR T1 - Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses. AN - 70746206; 18482687 AB - [(11)C](R)-Rolipram is a selective radioligand for positron emission tomography (PET) imaging of phosphodiesterase 4, an enzyme that metabolizes 3',5'-cyclic adenosine monophosphate. The aim of this study was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeys and humans. Whole-body PET images were acquired for 2 h after injecting [(11)C](R)-rolipram in eight healthy humans and three monkeys. The simple method of using a single two-dimensional (2D) planar image was compared to more time-consuming methods that used two (bisected) or four (quadrisected) tomographic images in the anteroposterior direction. Effective dose was 4.8 microGy/MBq based on 2D planar images. The effective dose was only slightly lower by 1% and 5% using the bisected and quadrisected images, respectively. Nevertheless, the two tomographic methods may have more accurately estimated the exposure of some organs (e.g., kidneys) that are asymmetrically located in the body or have radioactivity that appears to overlap on 2D planar images. Monkeys had a different biodistribution pattern compared to humans (e.g., greater urinary excretion) such that their data overestimated the effective dose in humans by 40%. The effective dose of [(11)C](R)-rolipram was modest and comparable to that of other (11)C-labeled radioligands. The simple and far less time-consuming 2D planar method provided accurate and somewhat more conservative estimates of effective dose than the two tomographic methods. Although monkeys are commonly used to estimate human radiation exposures, their data gave a considerable overestimation for this radioligand. JF - Nuclear medicine and biology AU - Sprague, David R AU - Fujita, Masahiro AU - Ryu, Yong Hoon AU - Liow, Jeih-San AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892-2035, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 493 EP - 500 VL - 35 IS - 4 SN - 0969-8051, 0969-8051 KW - Carbon Radioisotopes KW - 0 KW - Phosphodiesterase 4 Inhibitors KW - Radiopharmaceuticals KW - Cyclic Nucleotide Phosphodiesterases, Type 4 KW - EC 3.1.4.17 KW - Rolipram KW - K676NL63N7 KW - Index Medicus KW - Animals KW - Radiopharmaceuticals -- metabolism KW - Humans KW - Whole Body Imaging KW - Metabolic Clearance Rate KW - Tissue Distribution KW - Whole-Body Counting KW - Haplorhini KW - Cyclic Nucleotide Phosphodiesterases, Type 4 -- analysis KW - Radiation Dosage KW - Positron-Emission Tomography -- methods KW - Carbon Radioisotopes -- metabolism KW - Rolipram -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70746206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+and+biology&rft.atitle=Whole-body+biodistribution+and+radiation+dosimetry+in+monkeys+and+humans+of+the+phosphodiesterase+4+radioligand+%5B%2811%29C%5D%28R%29-rolipram%3A+comparison+of+two-dimensional+planar%2C+bisected+and+quadrisected+image+analyses.&rft.au=Sprague%2C+David+R%3BFujita%2C+Masahiro%3BRyu%2C+Yong+Hoon%3BLiow%2C+Jeih-San%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Sprague&rft.aufirst=David&rft.date=2008-05-01&rft.volume=35&rft.issue=4&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+and+biology&rft.issn=09698051&rft_id=info:doi/10.1016%2Fj.nucmedbio.2008.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-05 N1 - Date created - 2008-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Nucl Med. 2000 Apr;41(4):605-11 [10768560] J Nucl Med. 2007 Dec;48(12):2072-9 [18006619] Prog Nucleic Acid Res Mol Biol. 2001;69:249-315 [11550796] Synapse. 2001 Dec 15;42(4):258-65 [11746724] Bipolar Disord. 2002 Jun;4(3):183-94 [12180273] Eur J Nucl Med Mol Imaging. 2002 Dec;29(12):1680-3 [12458404] Neuropharmacology. 1983 Mar;22(3):267-72 [6302550] Xenobiotica. 1988 May;18(5):561-71 [3400274] Jpn J Pharmacol. 1988 Nov;48(3):357-64 [2906101] Xenobiotica. 1989 Jun;19(6):683-92 [2669364] Neuropsychobiology. 1992;26(1-2):59-64 [1475038] Drug Metab Dispos. 1993 Jul-Aug;21(4):682-9 [8104129] Xenobiotica. 1993 Nov;23(11):1277-88 [8310711] FEBS Lett. 1994 Aug 22;350(2-3):291-5 [8070581] Arch Gen Psychiatry. 1997 Jul;54(7):597-606 [9236543] Science. 1997 Oct 3;278(5335):58-63 [9311927] J Neurosci. 1999 Jan 15;19(2):610-8 [9880581] Synapse. 1999 Jan;31(1):41-50 [10025682] J Nucl Med. 2005 Jun;46(6):1023-7 [15937315] Neuroimage. 2005 Jul 15;26(4):1201-10 [15961054] Eur J Neurosci. 2005 Sep;22(6):1463-75 [16190900] J Nucl Med. 2007 Jan;48(1):100-7 [17204705] Nucl Med Biol. 2001 May;28(4):347-58 [11395307] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.nucmedbio.2008.02.004 ER - TY - JOUR T1 - High levels of carcinogenic polycyclic aromatic hydrocarbons in mate drinks. AN - 70740422; 18483349 AB - Drinking mate has been associated with cancers of the esophagus, oropharynx, larynx, lung, kidney, and bladder. We conducted this study to determine whether drinking mate could lead to substantial exposure to polycyclic aromatic hydrocarbons (PAH), including known carcinogens, such as benzo[a]pyrene. The concentrations of 21 individual PAHs were measured in dry leaves of eight commercial brands of yerba mate and in infusions made with hot (80 degrees C) or cold (5 degrees C) water. Measurements were done using gas chromatography/mass spectrometry, with deuterated PAHs as the surrogates. Infusions were made by adding water to the leaves, removing the resulting infusion after 5 min, and then adding more water to the remaining leaves. This process was repeated 12 times for each infusion temperature. The total concentrations of the 21 PAHs in different brands of yerba mate ranged from 536 to 2,906 ng/g dry leaves. Benzo[a]pyrene concentrations ranged from 8.03 to 53.3 ng/g dry leaves. For the mate infusions prepared using hot water and brand 1, 37% (1,092 of 2,906 ng) of the total measured PAHs and 50% (25.1 of 50 ng) of the benzo[a]pyrene content were released into the 12 infusions. Similar results were obtained for other hot and cold infusions. Very high concentrations of carcinogenic PAHs were found in yerba mate leaves and in hot and cold mate infusions. Our results support the hypothesis that the carcinogenicity of mate may be related to its PAH content. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Kamangar, Farin AU - Schantz, Michele M AU - Abnet, Christian C AU - Fagundes, Renato B AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. kamangaf@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1262 EP - 1268 VL - 17 IS - 5 SN - 1055-9965, 1055-9965 KW - Carcinogens KW - 0 KW - Polycyclic Aromatic Hydrocarbons KW - Index Medicus KW - Beverages -- analysis KW - Gas Chromatography-Mass Spectrometry KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Ilex paraguariensis -- chemistry KW - Carcinogens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70740422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=High+levels+of+carcinogenic+polycyclic+aromatic+hydrocarbons+in+mate+drinks.&rft.au=Kamangar%2C+Farin%3BSchantz%2C+Michele+M%3BAbnet%2C+Christian+C%3BFagundes%2C+Renato+B%3BDawsey%2C+Sanford+M&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2008-05-01&rft.volume=17&rft.issue=5&rft.spage=1262&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0025 ER - TY - JOUR T1 - Ethnic disparities in Americans of European descent versus Americans of African descent related to polymorphic ERCC1, ERCC2, XRCC1, and PARP1. AN - 70737886; 18483312 AB - Nucleotide excision repair (NER) and base excision repair (BER) pathways are DNA repair pathways that are important in carcinogenesis and in response to DNA-damaging chemotherapy. ERCC1 and ERCC2 are important molecular markers for NER; XRCC1 and PARP1 are important molecular markers for BER. Functional polymorphisms have been described that are associated with altered expression levels of these genes and with altered DNA repair capability. We assayed genomic DNA from 156 Americans of European descent and 164 Americans of African descent for the allelic frequencies of specific polymorphisms of ERCC1 N118N (500C>T), ERCC1 C8092A, ERCC2 K751Q (2282A>C), XRCC1 R399Q (1301G>A), XRCC1 R194W (685C>T), and PARP1 V762A (2446T>C). Differences were observed between Americans of European descent and Americans of African descent in the allelic frequencies of the ERCC1 N118N polymorphism (P < 0.000001). Differences were also observed between these two ethnic groups for ERCC2 K751Q (P = < 0.006675), XRCC1 R399Q (P < 0.000001), and PARP1 V762A (P = 0.000001). The ERCC1 N118N polymorphic variant that is seen most commonly in Americans of European descent is associated with a measurable reduction in NER function. ERCC1-mediated reduction in NER functionality affects the repair of cisplatin-DNA lesions. JF - Molecular cancer therapeutics AU - Gao, Rui AU - Price, Douglas K AU - Sissung, Tristan AU - Reed, Eddie AU - Figg, William D AD - Molecular Pharmacology Section, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, MD 20892, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1246 EP - 1250 VL - 7 IS - 5 SN - 1535-7163, 1535-7163 KW - DNA-Binding Proteins KW - 0 KW - X-ray repair cross complementing protein 1 KW - PARP1 protein, human KW - EC 2.4.2.30 KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerases KW - ERCC1 protein, human KW - EC 3.1.- KW - Endonucleases KW - Xeroderma Pigmentosum Group D Protein KW - EC 3.6.4.12 KW - ERCC2 protein, human KW - EC 5.99.- KW - Index Medicus KW - United States KW - DNA Repair KW - Gene Frequency KW - Humans KW - Europe -- ethnology KW - Poly(ADP-ribose) Polymerases -- genetics KW - Xeroderma Pigmentosum Group D Protein -- genetics KW - Polymorphism, Genetic KW - DNA-Binding Proteins -- genetics KW - African Americans -- genetics KW - European Continental Ancestry Group -- ethnology KW - Endonucleases -- genetics KW - European Continental Ancestry Group -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70737886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Ethnic+disparities+in+Americans+of+European+descent+versus+Americans+of+African+descent+related+to+polymorphic+ERCC1%2C+ERCC2%2C+XRCC1%2C+and+PARP1.&rft.au=Gao%2C+Rui%3BPrice%2C+Douglas+K%3BSissung%2C+Tristan%3BReed%2C+Eddie%3BFigg%2C+William+D&rft.aulast=Gao&rft.aufirst=Rui&rft.date=2008-05-01&rft.volume=7&rft.issue=5&rft.spage=1246&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/10.1158%2F1535-7163.MCT-07-2206 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-22 N1 - Date created - 2008-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1987 Nov 25;15(22):9195-213 [3684592] Lung Cancer. 2007 May;56(2):281-8 [17222938] J Biol Chem. 1995 Feb 10;270(6):2415-8 [7852297] J Natl Cancer Inst. 1995 Nov 15;87(22):1686-93 [7473817] J Biol Chem. 1996 Apr 5;271(14):8285-94 [8626523] Curr Opin Genet Dev. 1996 Feb;6(1):26-33 [8791490] Mutat Res. 1997 Sep;382(1-2):13-20 [9360634] Cancer Treat Rev. 1998 Oct;24(5):331-44 [9861196] Blood. 2004 Dec 15;104(13):3872-7 [15339847] Pharmacogenomics J. 2005;5(1):54-9 [15534626] Cancer Res. 2005 Feb 1;65(3):722-6 [15705867] Cancer Detect Prev. 1999;23(6):463-73 [10571656] Carcinogenesis. 2000 Apr;21(4):551-5 [10753184] Cancer Res. 2001 Feb 15;61(4):1354-7 [11245433] Cancer Epidemiol Biomarkers Prev. 2001 Mar;10(3):217-22 [11303590] Nature. 2001 May 17;411(6835):366-74 [11357144] Cancer Res. 2001 Dec 15;61(24):8654-8 [11751380] Teratology. 2001 Dec;64(6):283-91 [11754170] J Natl Cancer Inst Monogr. 2001;(30):36-43 [11773290] Cancer Res. 2002 Aug 15;62(16):4630-6 [12183419] Int J Clin Pharmacol Ther. 2002 Aug;40(8):354-67 [12467304] J Clin Oncol. 2003 Feb 1;21(3):413-20 [12560428] Cancer Metastasis Rev. 2003 Mar;22(1):39-46 [12716035] Nucleic Acids Res. 2003 Oct 1;31(19):5526-33 [14500814] Cancer. 2004 Jul 1;101(1):66-76 [15221990] J Clin Oncol. 2004 Jul 1;22(13):2594-601 [15173214] Am J Epidemiol. 2007 Jul 1;166(1):71-8 [17426038] Cancer Res. 2004 Jun 15;64(12):4378-84 [15205355] Ai Zheng. 2004 Aug;23(8):865-8 [15301704] Cancer Res. 2004 Sep 1;64(17):6344-8 [15342424] Urology. 2004 Oct;64(4):738-43 [15491712] Science. 1977 Jul 8;197(4299):165-7 [877547] Cell. 1986 Mar 28;44(6):913-23 [2420469] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):491-6 [15734977] Clin Cancer Res. 2005 Sep 1;11(17):6100-2 [16144907] Clin Cancer Res. 2005 Sep 1;11(17):6212-7 [16144923] Clin Adv Hematol Oncol. 2003 Mar;1(3):162-6 [16224397] Curr Opin Oncol. 2006 Mar;18(2):144-50 [16462183] Oncology (Williston Park). 2005 Dec;19(14):1759-67; discussion 1768, 1772-4, 1777-8 [16506631] Oncogene. 2006 Mar 13;25(11):1612-9 [16550161] Cancer. 2006 Jun 1;106(11):2421-7 [16649224] Exp Mol Med. 2006 Jun 30;38(3):320-4 [16819291] Cancer Genet Cytogenet. 2006 Aug;169(1):27-32 [16875933] Br J Cancer. 2006 Sep 4;95(5):561-70 [16880786] N Engl J Med. 2006 Sep 7;355(10):1054-5 [16957152] J Clin Oncol. 2006 Sep 10;24(26):4333-9 [16896002] Oncologist. 2006 Oct;11(9):981-7 [17030638] Gynecol Oncol. 2006 Dec;103(3):1031-7 [16875718] Biochem Biophys Res Commun. 2007 Mar 2;354(1):122-6 [17214964] Ann Oncol. 2007 Mar;18(3):522-8 [17229776] Breast Cancer Res Treat. 2007 May;102(3):347-56 [17028980] Nature. 1993 Oct 28;365(6449):852-5 [8413672] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-07-2206 ER - TY - JOUR T1 - Delineation of the protein module that anchors HMGN proteins to nucleosomes in the chromatin of living cells. AN - 70489181; 18299391 AB - Numerous nuclear proteins bind to chromatin by targeting unique DNA sequences or specific histone modifications. In contrast, HMGN proteins recognize the generic structure of the 147-bp nucleosome core particle. HMGNs alter the structure and activity of chromatin by binding to nucleosomes; however, the determinants of the specific interaction of HMGNs with chromatin are not known. Here we use systematic mutagenesis, quantitative fluorescence recovery after photobleaching, fluorescence imaging, and mobility shift assays to identify the determinants important for the specific binding of these proteins to both the chromatin of living cells and to purified nucleosomes. We find that several regions of the protein affect the affinity of HMGNs to chromatin; however, the conserved sequence RRSARLSA, is the sole determinant of the specific interaction of HMGNs with nucleosomes. Within this sequence, each of the 4 amino acids in the R-S-RL motif are the only residues absolutely essential for anchoring HMGN protein to nucleosomes, both in vivo and in vitro. Our studies identify a new chromatin-binding module that specifically recognizes nucleosome cores independently of DNA sequence or histone tail modifications. JF - Molecular and cellular biology AU - Ueda, Tetsuya AU - Catez, Frédéric AU - Gerlitz, Gabi AU - Bustin, Michael AD - Protein Section, Laboratory of Metabolism, National Cancer Institute, NIH, Bethesda, MD 20892. bustin@helix.nih.gov. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2872 EP - 2883 VL - 28 IS - 9 KW - Chromatin KW - 0 KW - HMGN1 Protein KW - HMGN2 Protein KW - Nucleosomes KW - Index Medicus KW - Animals KW - Amino Acid Motifs KW - Cells, Cultured KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Protein Binding KW - Mutation KW - Mice, Knockout KW - HMGN1 Protein -- metabolism KW - Chromatin -- metabolism KW - HMGN2 Protein -- metabolism KW - Nucleosomes -- metabolism KW - HMGN1 Protein -- genetics KW - HMGN2 Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70489181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Delineation+of+the+protein+module+that+anchors+HMGN+proteins+to+nucleosomes+in+the+chromatin+of+living+cells.&rft.au=Ueda%2C+Tetsuya%3BCatez%2C+Fr%C3%A9d%C3%A9ric%3BGerlitz%2C+Gabi%3BBustin%2C+Michael&rft.aulast=Ueda&rft.aufirst=Tetsuya&rft.date=2008-05-01&rft.volume=28&rft.issue=9&rft.spage=2872&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.02181-07 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1999 Dec 17;294(5):1351-62 [10600390] Biochemistry. 2006 Dec 19;45(50):15092-9 [17154547] Nature. 2000 Apr 6;404(6778):604-9 [10766243] Annu Rev Pharmacol Toxicol. 2000;40:617-47 [10836149] Nat Rev Mol Cell Biol. 2001 Jun;2(6):422-32 [11389466] Nat Rev Mol Cell Biol. 2001 Jun;2(6):444-56 [11389468] Mol Cell Biol. 2001 Aug;21(15):5169-78 [11438671] Trends Biochem Sci. 2001 Jul;26(7):431-7 [11440855] J Biol Chem. 2001 Jul 13;276(28):25959-69 [11356838] EMBO Rep. 2002 Aug;3(8):760-6 [12151335] Mol Cell Biol. 2002 Oct;22(19):6809-19 [12215538] EMBO J. 2003 Apr 1;22(7):1665-75 [12660172] Methods Enzymol. 2004;375:323-42 [14870676] Mol Cell Biol. 2004 May;24(10):4321-8 [15121851] Mol Cell Biol. 2004 Jul;24(14):6393-402 [15226439] Mol Cell. 2004 Aug 27;15(4):573-84 [15327773] FEBS Lett. 1973 May 15;32(1):46-51 [4715687] Eur J Biochem. 1978 Mar;84(1):173-7 [565710] Science. 1980 Sep 26;209(4464):1534-6 [7433974] J Mol Biol. 1989 Apr 5;206(3):451-63 [2716057] Trends Cell Biol. 2007 Feb;17(2):72-9 [17169561] Cell. 2007 Feb 23;128(4):693-705 [17320507] Cell. 2007 Feb 23;128(4):707-19 [17320508] Nature. 2007 May 24;447(7143):407-12 [17522673] Nat Struct Mol Biol. 2007 Nov;14(11):1025-40 [17984965] Mol Cell Biol. 2007 Dec;27(24):8859-73 [17938209] Trends Biochem Sci. 1989 Apr;14(4):137-40 [2499084] J Mol Biol. 1992 Nov 20;228(2):442-9 [1453455] J Mol Biol. 1994 Feb 11;236(1):189-98 [8107104] Nucleic Acids Res. 1994 Oct 25;22(21):4520-6 [7971283] Mol Cell Biol. 1995 Dec;15(12):6663-9 [8524231] Proc Natl Acad Sci U S A. 1998 May 12;95(10):5468-73 [9576905] Mol Cell Biol. 1999 Aug;19(8):5237-46 [10409715] Mol Cell. 2005 Mar 4;17(5):617-20 [15749012] Cancer Res. 2005 Aug 1;65(15):6711-8 [16061652] EMBO J. 2005 Sep 7;24(17):3038-48 [16096646] Curr Opin Genet Dev. 2005 Oct;15(5):496-506 [16102963] Mol Cell Biol. 2006 Jan;26(2):592-604 [16382150] Differentiation. 2006 Feb;74(1):19-29 [16466397] J Biol Chem. 2006 Apr 14;281(15):10182-7 [16484217] J Biol Chem. 2000 Mar 3;275(9):6368-74 [10692437] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.02181-07 ER - TY - JOUR T1 - Reconstruction of individual radiation doses for a case-control study of thyroid cancer in French Polynesia. AN - 70487252; 18403963 AB - Forty-one atmospheric nuclear weapons tests (plus five safety tests) were conducted in French Polynesia between 1966 and 1974. To evaluate the potential role of atmospheric nuclear weapons testing on a high incidence of thyroid cancer observed since 1985 in French Polynesia, a population-based case-control study was performed. The study included 602 subjects, either cases or controls, all aged less than 40 y at the end of nuclear weapons testing in 1974. Radiation doses to the thyroids of the study subjects were assessed based on the available historical results of radiation measurements. These were mainly found in the annual reports on the radiological situation in French Polynesia that had been sent to the UNSCEAR Secretariat. For each atmospheric nuclear weapons test that contributed substantially to the local deposition of radionuclides, the radiation dose to the thyroid from I intake was estimated. In addition, thyroid doses from the intake of short-lived radioiodines (132I, 133I, 135I) and 132Te, external exposure from gamma-emitted radionuclides deposited on the ground, and ingestion of long-lived Cs were reconstructed. The mean thyroid dose among the study subjects was found to be around 3 mGy while the highest dose was estimated to be around 40 mGy. Doses from short-lived iodine and tellurium isotopes ranged up to 10 mGy. Thyroid doses from external exposure ranged up to 3 mGy, while those from internal exposure due to cesium ingestion did not exceed 1 mGy. The dose estimates that have been obtained are based on a rather limited number of radiation measurements performed on a limited number of islands and are highly uncertain. A thorough compilation of the results of all radiation monitoring that was performed in French Polynesia in 1966-1974 would be likely to greatly improve the reliability and the precision of the dose estimates. JF - Health physics AU - Drozdovitch, Vladimir AU - Bouville, André AU - Doyon, Françoise AU - Brindel, Pauline AU - Cardis, Elisabeth AU - de Vathaire, Florent AD - International Agency for Research on Cancer, 150, Cours Albert Thomas, Lyon, Cedex 08, F-69372, France. drozdovv@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 418 EP - 433 VL - 94 IS - 5 SN - 0017-9078, 0017-9078 KW - Air Pollutants, Radioactive KW - 0 KW - Radioactive Fallout KW - Index Medicus KW - Humans KW - Case-Control Studies KW - Time Factors KW - Polynesia -- epidemiology KW - Thyroid Neoplasms -- epidemiology KW - Radiation Dosage KW - Neoplasms, Radiation-Induced -- etiology KW - Nuclear Warfare KW - Neoplasms, Radiation-Induced -- epidemiology KW - Thyroid Neoplasms -- etiology KW - Risk Assessment -- methods KW - Air Pollutants, Radioactive -- toxicity KW - Radioactive Fallout -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70487252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Reconstruction+of+individual+radiation+doses+for+a+case-control+study+of+thyroid+cancer+in+French+Polynesia.&rft.au=Drozdovitch%2C+Vladimir%3BBouville%2C+Andr%C3%A9%3BDoyon%2C+Fran%C3%A7oise%3BBrindel%2C+Pauline%3BCardis%2C+Elisabeth%3Bde+Vathaire%2C+Florent&rft.aulast=Drozdovitch&rft.aufirst=Vladimir&rft.date=2008-05-01&rft.volume=94&rft.issue=5&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/10.1097%2F01.HP.0000299293.06218.88 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-02 N1 - Date created - 2008-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann ICRP. 2002;32(3-4):5-265 [14506981] Health Phys. 1990 Nov;59(5):693-713 [2211124] Health Phys. 2002 May;82(5):706-25 [12003020] Cancer Causes Control. 2000 Jan;11(1):59-63 [10680730] Ann ICRP. 1996;26(1):1-91 [8886253] Radiat Res. 2006 Feb;165(2):208-22 [16435919] Radiat Environ Biophys. 2002 Mar;41(1):61-7 [12014413] Health Phys. 1989 Sep;57(3):471-5 [2777553] Health Phys. 1983 Sep;45(3):731-44 [6885479] Health Phys. 2004 Jun;86(6):565-85 [15167120] Health Phys. 1958 Dec;1(3):255-67 [13620167] Health Phys. 1990 Nov;59(5):555-63 [2211115] Ann ICRP. 1995;25(3-4):1-405 [8735008] Ann ICRP. 1993;23(3-4):1-167 [7978694] Health Phys. 1993 Mar;64(3):232-52 [8432643] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/01.HP.0000299293.06218.88 ER - TY - JOUR T1 - Borrelia burgdorferi membranes are the primary targets of reactive oxygen species. AN - 70485401; 18373524 AB - Spirochetes living in an oxygen-rich environment or when challenged by host immune cells are exposed to reactive oxygen species (ROS). These species can harm/destroy cysteinyl residues, iron-sulphur clusters, DNA and polyunsaturated lipids, leading to inhibition of growth or cell death. Because Borrelia burgdorferi contains no intracellular iron, DNA is most likely not a major target for ROS via Fenton reaction. In support of this, growth of B. burgdorferi in the presence of 5 mM H(2)O(2) had no effect on the DNA mutation rate (spontaneous coumermycin A1 resistance), and cells treated with 10 mM t-butyl hydroperoxide or 10 mM H(2)O(2) show no increase in DNA damage. Unlike most bacteria, B. burgdorferi incorporates ROS-susceptible polyunsaturated fatty acids from the environment into their membranes. Analysis of lipoxidase-treated B. burgdorferi cells by Electron Microscopy showed significant irregularities indicative of membrane damage. Fatty acid analysis of cells treated with lipoxidase indicated that host-derived linoleic acid had been dramatically reduced (50-fold) in these cells, with a corresponding increase in the levels of malondialdehyde by-product (fourfold). These data suggest that B. burgdorferi membrane lipids are targets for attack by ROS encountered in the various stages of the infective cycle. JF - Molecular microbiology AU - Boylan, Julie A AU - Lawrence, Kevin A AU - Downey, Jennifer S AU - Gherardini, Frank C AD - National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 S 4th Street, Hamilton, MT 59840, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 786 EP - 799 VL - 68 IS - 3 KW - DNA, Bacterial KW - 0 KW - Lipids KW - Oxidants KW - Reactive Oxygen Species KW - Index Medicus KW - Mutation -- drug effects KW - Lipids -- antagonists & inhibitors KW - Oxidants -- pharmacology KW - Humans KW - Oxidative Stress KW - Microscopy, Electron KW - DNA, Bacterial -- drug effects KW - Lipids -- analysis KW - Cell Membrane -- drug effects KW - Cell Membrane -- ultrastructure KW - Cell Membrane -- chemistry KW - Cell Membrane -- metabolism KW - Borrelia burgdorferi -- metabolism KW - Reactive Oxygen Species -- pharmacology KW - Borrelia burgdorferi -- drug effects KW - Borrelia burgdorferi -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70485401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Borrelia+burgdorferi+membranes+are+the+primary+targets+of+reactive+oxygen+species.&rft.au=Boylan%2C+Julie+A%3BLawrence%2C+Kevin+A%3BDowney%2C+Jennifer+S%3BGherardini%2C+Frank+C&rft.aulast=Boylan&rft.aufirst=Julie&rft.date=2008-05-01&rft.volume=68&rft.issue=3&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=1365-2958&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06204.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-02 N1 - Date created - 2008-04-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2000 Jun 2;288(5471):1651-3 [10834845] Acta Biochim Pol. 2007;54(3):413-34 [17893748] Free Radic Biol Med. 2000 Jun 1;28(11):1611-8 [10938457] J Bacteriol. 2001 Mar;183(6):1961-73 [11222594] Free Radic Biol Med. 2001 Jul 15;31(2):164-74 [11440828] Annu Rev Microbiol. 2003;57:395-418 [14527285] Biochemistry. 1972 Sep 12;11(19):3610-8 [4626532] Yale J Biol Med. 1984 Jul-Aug;57(4):521-5 [6393604] Adv Enzymol Relat Areas Mol Biol. 1987;60:1-34 [2444076] Chem Phys Lipids. 1987 Jul-Sep;44(2-4):255-76 [3311419] Environ Mol Mutagen. 1988;12(4):431-77 [2461302] J Bacteriol. 1989 Apr;171(4):2049-55 [2649484] Trends Biochem Sci. 1990 Apr;15(4):129-35 [2187293] J Biol Chem. 1991 Apr 15;266(11):6957-65 [1849898] Free Radic Biol Med. 1991;11(1):81-128 [1937131] J Bacteriol. 1991 Nov;173(22):7233-9 [1938918] Biochemistry. 1992 Apr 14;31(14):3703-8 [1567824] Infect Immun. 1993 May;61(5):2192-5 [8478109] J Bacteriol. 1994 May;176(10):3072-5 [8188609] Mol Gen Genet. 1996 Jun 12;251(3):352-7 [8676878] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13635-40 [8942986] EMBO J. 1996 Dec 2;15(23):6416-25 [8978669] Nature. 1997 Dec 11;390(6660):580-6 [9403685] Curr Opin Microbiol. 1999 Apr;2(2):188-94 [10322176] Mol Microbiol. 2005 Nov;58(3):625-35 [16238614] Biochem Biophys Res Commun. 2005 Dec 16;338(2):1222-8 [16256945] Clin Biochem. 2006 Sep;39(9):947-54 [16781699] Biochim Biophys Acta. 2006 Nov;1760(11):1596-603 [17069977] Infect Immun. 2006 Dec;74(12):6839-46 [17030577] J Bacteriol. 2007 Mar;189(5):1616-26 [17189367] Nature. 2007 Jun 21;447(7147):924-31 [17581575] FEBS Lett. 2000 Jun 2;474(2-3):137-40 [10838073] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06204.x ER - TY - JOUR T1 - Weekly docetaxel versus CMF as adjuvant chemotherapy for elderly breast cancer patients: safety data from the multicentre phase 3 randomised ELDA trial. AN - 70477956; 18160303 AB - Within an ongoing multicentre phase 3 randomised trial (ELDA, cancertrials.gov ID: NCT00331097), early breast cancer patients, 65-79 years old, with average to high risk of recurrence, are randomly assigned to receive CMF (cyclophosphamide 600 mg/m2, methotrexate 40 mg/m2, fluorouracil 600 mg/m2, days 1-8) or docetaxel (35 mg/m2 days 1-8-15), every 4 weeks. Here we report an unplanned safety analysis prompted by an amendment introducing creatinine clearance as a tool to adjust methotrexate dose. Before such change, 101 patients with a median age of 70 were randomly assigned CMF (53 patients) or docetaxel (48 patients). At least one grades 3-4 toxic event of any type was reported in 40 (75.5%) and 19 (39.6%) patients with CMF and docetaxel, respectively (p=0.0002). Grades 3-4 hematological events were observed in 37 (69.8%) vs. 4 (8.3%) cases (p<0.0001) and grades 3-4 non-hematological toxicity in 12 (22.6%) vs. 15 (31.2%) patients (p=0.11), with CMF and docetaxel, respectively. A higher incidence of anemia, neutropenia, thrombocytopenia and febrile neutropenia was reported with CMF. Constipation, mucositis, nausea and vomiting were more common with CMF; diarrhoea, abdominal pain, dysgeusia, neuropathy and liver toxicity were more frequent with docetaxel. No significant interaction was found between the occurrence of severe toxicity and baseline variables, including creatinine clearance and geriatric activity scales. In conclusion, weekly docetaxel appears to be less toxic than CMF in terms of hematological toxicity. JF - Critical reviews in oncology/hematology AU - Nuzzo, Francesco AU - Morabito, Alessandro AU - De Maio, Ermelinda AU - Di Rella, Francesca AU - Gravina, Adriano AU - Labonia, Vincenzo AU - Landi, Gabriella AU - Pacilio, Carmen AU - Piccirillo, Maria Carmela AU - Rossi, Emanuela AU - D'Aiuto, Giuseppe AU - Thomas, Renato AU - Gori, Stefania AU - Colozza, Mariantonietta AU - De Placido, Sabino AU - Lauria, Rossella AU - Signoriello, Giuseppe AU - Gallo, Ciro AU - Perrone, Francesco AU - de Matteis, Andrea AD - National Cancer Institute, Naples, Italy. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 171 EP - 180 VL - 66 IS - 2 SN - 1040-8428, 1040-8428 KW - Antineoplastic Agents KW - 0 KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - Cyclophosphamide KW - 8N3DW7272P KW - Fluorouracil KW - U3P01618RT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Fluorouracil -- administration & dosage KW - Cyclophosphamide -- administration & dosage KW - Hematologic Diseases -- chemically induced KW - Drug Administration Schedule KW - Age Factors KW - Patient Compliance KW - Humans KW - Treatment Outcome KW - Aged KW - Methotrexate -- administration & dosage KW - Italy KW - Female KW - Chemotherapy, Adjuvant KW - Breast Neoplasms -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Taxoids -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Taxoids -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70477956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+oncology%2Fhematology&rft.atitle=Weekly+docetaxel+versus+CMF+as+adjuvant+chemotherapy+for+elderly+breast+cancer+patients%3A+safety+data+from+the+multicentre+phase+3+randomised+ELDA+trial.&rft.au=Nuzzo%2C+Francesco%3BMorabito%2C+Alessandro%3BDe+Maio%2C+Ermelinda%3BDi+Rella%2C+Francesca%3BGravina%2C+Adriano%3BLabonia%2C+Vincenzo%3BLandi%2C+Gabriella%3BPacilio%2C+Carmen%3BPiccirillo%2C+Maria+Carmela%3BRossi%2C+Emanuela%3BD%27Aiuto%2C+Giuseppe%3BThomas%2C+Renato%3BGori%2C+Stefania%3BColozza%2C+Mariantonietta%3BDe+Placido%2C+Sabino%3BLauria%2C+Rossella%3BSignoriello%2C+Giuseppe%3BGallo%2C+Ciro%3BPerrone%2C+Francesco%3Bde+Matteis%2C+Andrea&rft.aulast=Nuzzo&rft.aufirst=Francesco&rft.date=2008-05-01&rft.volume=66&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+oncology%2Fhematology&rft.issn=10408428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-04-04 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00331097; ClinicalTrials.gov N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of insulin-like growth factor-1R system in colorectal carcinogenesis. AN - 70472267; 17977741 AB - The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy. JF - Critical reviews in oncology/hematology AU - Donovan, Erin A AU - Kummar, Shivaani AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 10/12N226, Bethesda, MD 20892, United States. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 91 EP - 98 VL - 66 IS - 2 SN - 1040-8428, 1040-8428 KW - Antibodies KW - 0 KW - Antineoplastic Agents KW - Oligonucleotides, Antisense KW - Protein Kinase Inhibitors KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Insulin-Like Growth Factor II KW - 67763-97-7 KW - Receptor, IGF Type 1 KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Oligonucleotides, Antisense -- therapeutic use KW - Antibodies -- therapeutic use KW - Protein Kinase Inhibitors -- therapeutic use KW - Humans KW - Antineoplastic Agents -- therapeutic use KW - Receptor, IGF Type 1 -- immunology KW - Colorectal Neoplasms -- metabolism KW - Receptor, IGF Type 1 -- metabolism KW - Cell Transformation, Neoplastic -- metabolism KW - Colorectal Neoplasms -- immunology KW - Insulin-Like Growth Factor I -- metabolism KW - Receptor, IGF Type 1 -- drug effects KW - Insulin-Like Growth Factor II -- metabolism KW - Colorectal Neoplasms -- genetics KW - Colorectal Neoplasms -- epidemiology KW - Colorectal Neoplasms -- enzymology KW - Colorectal Neoplasms -- drug therapy KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70472267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+oncology%2Fhematology&rft.atitle=Role+of+insulin-like+growth+factor-1R+system+in+colorectal+carcinogenesis.&rft.au=Donovan%2C+Erin+A%3BKummar%2C+Shivaani&rft.aulast=Donovan&rft.aufirst=Erin&rft.date=2008-05-01&rft.volume=66&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+oncology%2Fhematology&rft.issn=10408428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2001 Nov 30;85(11):1695-9 [11742490] Cancer Res. 2002 Feb 15;62(4):1030-5 [11861378] Gut. 2002 May;50(5):642-6 [11950809] Cell Death Differ. 2002 Jul;9(7):768-79 [12058282] Cancer Causes Control. 2002 Jun;13(5):395-400 [12146843] Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):901-5 [12223436] Cancer. 2002 Nov 15;95(10):2086-95 [12412161] Cancer Res. 2003 Feb 1;63(3):627-35 [12566306] Am J Epidemiol. 2003 Sep 1;158(5):424-31 [12936897] Cancer Res. 2003 Aug 15;63(16):5073-83 [12941837] J Biol Chem. 2003 Oct 17;278(42):40442-54 [12869569] Cancer Res. 2003 Dec 15;63(24):8912-21 [14695208] Cancer Res. 2004 Jan 1;64(1):236-42 [14729630] Cancer Cell. 2004 Mar;5(3):221-30 [15050914] Gastroenterology. 2004 Apr;126(4):964-70 [15057734] Lancet. 2004 Apr 24;363(9418):1346-53 [15110491] Nat Rev Cancer. 2004 Jul;4(7):505-18 [15229476] Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11217-21 [8248231] Cancer Res. 1995 Jan 15;55(2):249-52 [7812953] Science. 1997 May 23;276(5316):1268-72 [9157888] Clin Endocrinol (Oxf). 1997 Jul;47(1):17-22 [9302367] Eur J Cancer. 1997 Jun;33(7):1108-13 [9376191] J Exp Ther Oncol. 1996 Nov;1(6):385-9 [9414429] J Clin Endocrinol Metab. 1998 Aug;83(8):2730-4 [9709939] Cancer Res. 1998 Sep 1;58(17):4008-14 [9731515] Clin Cancer Res. 1998 Nov;4(11):2647-55 [9829727] J Natl Cancer Inst. 1999 Apr 7;91(7):620-5 [10203281] Horm Metab Res. 1999 Feb-Mar;31(2-3):97-102 [10226788] Int J Cancer. 1999 Nov 12;83(4):497-505 [10508486] Int J Cancer. 2005 Jan 10;113(2):316-28 [15386423] Clin Cancer Res. 2004 Dec 1;10(23):7950-7 [15585629] Clin Cancer Res. 2004 Dec 15;10(24):8434-41 [15623623] Clin Cancer Res. 2005 Mar 1;11(5):2063-73 [15756033] Int J Colorectal Dis. 2005 May;20(3):203-20 [15650828] Cancer Res. 2005 May 1;65(9):3781-7 [15867374] J Biol Chem. 2005 May 20;280(20):19665-72 [15757893] Cytokine Growth Factor Rev. 2005 Aug-Oct;16(4-5):407-20 [15886048] Drug Discov Today. 2005 Aug 1;10(15):1041-7 [16055020] Mol Cancer Ther. 2005 Aug;4(8):1214-21 [16093437] Int J Oncol. 2006 Feb;28(2):329-35 [16391786] Cancer Res. 2006 Jan 1;66(1):362-71 [16397250] Gut. 2006 May;55(5):689-94 [16299029] World J Gastroenterol. 2006 Sep 21;12(35):5635-43 [17007015] Hum Pathol. 1999 Oct;30(10):1128-33 [10534157] Cancer Epidemiol Biomarkers Prev. 2000 Apr;9(4):345-9 [10794477] J Clin Endocrinol Metab. 2000 Sep;85(9):3417-24 [10999843] J Natl Cancer Inst. 2000 Oct 4;92(19):1592-600 [11018095] J Surg Res. 2000 Nov;94(1):1-5 [11038295] J Natl Cancer Inst. 2000 Dec 6;92(23):1947-50 [11106691] Oncogene. 2000 Nov 16;19(48):5517-24 [11114729] J Clin Oncol. 2001 Apr 15;19(8):2189-200 [11304771] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2. AN - 70463922; 17979196 AB - Multiple computational methods have been employed in a comparative study of thyrotropin-releasing hormone receptors 1 and 2 (TRH-R1 and TRH-R2) to explore the structural bases for the different functional properties of these G protein-coupled receptors. Three-dimensional models of both murine TRH receptors have been built and optimized by means of homology modeling based on the crystal structure of bovine rhodopsin, molecular dynamics simulations, and energy minimizations in a membrane-aqueous environment. The comparison between the two models showed a correlation between the higher flexibility and higher basal activity of TRH-R2 versus the lesser flexibility and lower basal activity of TRH-R1 and supported the involvement of the highly conserved W6.48 in the signaling process. A correlation between the level of basal activity and conformational changes of TM5 was detected also. Comparison between models of the wild type receptors and their W6.48A mutants, which have reversed basal activities compared with their respective wild types, further supported these correlations. A flexible molecular docking procedure revealed that TRH establishes a direct interaction with W6.48 in TRH-R2 but not in TRH-R1. We designed and performed new mutagenesis experiments that strongly supported these observations. JF - Proteins AU - Deflorian, Francesca AU - Engel, Stanislav AU - Colson, Anny-Odile AU - Raaka, Bruce M AU - Gershengorn, Marvin C AU - Costanzi, Stefano AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive, and Kidney Diseases, NIH, Bethesda, Maryland 20892-5646, USA. Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 783 EP - 794 VL - 71 IS - 2 KW - Receptors, Thyrotropin-Releasing Hormone KW - 0 KW - TRH-R1 protein, mouse KW - TRH-R2 protein, mouse KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - Rhodopsin KW - 9009-81-8 KW - Index Medicus KW - Animals KW - Computer Simulation KW - Models, Molecular KW - Amino Acid Sequence KW - Mice KW - Monte Carlo Method KW - Protein Binding KW - Binding Sites KW - Cattle KW - Sequence Alignment KW - Thyrotropin-Releasing Hormone -- metabolism KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Rhodopsin -- chemistry KW - Protein Conformation KW - Receptors, Thyrotropin-Releasing Hormone -- chemistry KW - Receptors, Thyrotropin-Releasing Hormone -- genetics KW - Receptors, Thyrotropin-Releasing Hormone -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70463922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins&rft.atitle=Understanding+the+structural+and+functional+differences+between+mouse+thyrotropin-releasing+hormone+receptors+1+and+2.&rft.au=Deflorian%2C+Francesca%3BEngel%2C+Stanislav%3BColson%2C+Anny-Odile%3BRaaka%2C+Bruce+M%3BGershengorn%2C+Marvin+C%3BCostanzi%2C+Stefano&rft.aulast=Deflorian&rft.aufirst=Francesca&rft.date=2008-05-01&rft.volume=71&rft.issue=2&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Proteins&rft.issn=1097-0134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-02 N1 - Date created - 2008-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reduced posterior mesofrontal cortex activation by risky rewards in substance-dependent patients. AN - 70398422; 18295984 AB - Substance-dependent individuals show disadvantageous decision-making, as well as alterated frontocortical recruitment when performing experimental tasks. We investigated whether substance-dependent patients (SDP) would show blunted recruitment of posterior mesofrontal cortex (PMC) by a conflict between concurrently increasing reward and risk of penalty in a monetary game of "chicken." SDP and controls performed: motor control (no reward) trials, guaranteed reward trials in which reward was not at risk, and risky trials where subjects were required to terminate their reward accrual before a secret varying time limit or else "bust" and forfeit that trial's winnings (low penalty) or the current trial's winnings plus an equal amount of previous winnings (high penalty). Reward accrual duration at risk of "busting" correlated negatively with trait neuroticism. The contrast between winning guaranteed reward versus non-reward activated the caudate head bilaterally in SDP but not controls. Accumulation of money at risk of low- or high-penalty (contrasted with accumulating guaranteed money) activated the PMC in both groups, but with a greater magnitude and more anterior extent in controls. Pre-decision signal increase in a PMC volume of interest negatively correlated with risk-taking in low-penalty trials, and was blunted in SDP relative to controls under both penalty conditions after controlling for individual differences in actual risk-taking and the higher neuroticism of SDP. These data suggest that SDP are characterized by a combination of: (a) striatal hypersensitivity to reward, and (b) under-recruitment of the specialized conflict-monitoring circuitry of the PMC when reward entails potential penalties. JF - Drug and alcohol dependence AU - Bjork, James M AU - Momenan, Reza AU - Smith, Ashley R AU - Hommer, Daniel W AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA. bjork@mail.nih.gov Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 115 EP - 128 VL - 95 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Conflict (Psychology) KW - Dominance, Cerebral -- physiology KW - Gyrus Cinguli -- physiopathology KW - Punishment KW - Humans KW - Caudate Nucleus -- physiopathology KW - Character KW - Comorbidity KW - Nerve Net -- physiopathology KW - Brain Mapping KW - Corpus Striatum -- physiopathology KW - Oxygen Consumption -- physiology KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Frontal Lobe -- physiopathology KW - Magnetic Resonance Imaging KW - Decision Making -- physiology KW - Recruitment, Neurophysiological -- physiology KW - Risk-Taking KW - Motivation KW - Cocaine-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Cocaine-Related Disorders -- rehabilitation KW - Reward KW - Marijuana Abuse -- rehabilitation KW - Cocaine-Related Disorders -- physiopathology KW - Marijuana Abuse -- psychology KW - Alcoholism -- physiopathology KW - Image Processing, Computer-Assisted KW - Marijuana Abuse -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70398422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Reduced+posterior+mesofrontal+cortex+activation+by+risky+rewards+in+substance-dependent+patients.&rft.au=Bjork%2C+James+M%3BMomenan%2C+Reza%3BSmith%2C+Ashley+R%3BHommer%2C+Daniel+W&rft.aulast=Bjork&rft.aufirst=James&rft.date=2008-05-01&rft.volume=95&rft.issue=1-2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.12.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-11 N1 - Date created - 2008-03-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res Cogn Brain Res. 2005 Apr;23(1):107-18 [15795138] J Neurosci. 2006 Sep 13;26(37):9530-7 [16971537] Alcohol Alcohol. 2005 May-Jun;40(3):194-200 [15668210] Nat Rev Neurosci. 2005 May;6(5):363-75 [15832198] Alcohol. 2004 Oct-Nov;34(2-3):133-50 [15902907] Alcohol Clin Exp Res. 2005 Sep;29(9):1590-600 [16205359] Nat Neurosci. 2005 Nov;8(11):1450-7 [16251987] J Neurosci. 2006 Jan 4;26(1):186-92 [16399686] J Neurosci. 2006 Apr 12;26(15):4063-70 [16611823] J Neurosci. 2006 May 3;26(18):4769-73 [16672649] Psychopharmacology (Berl). 1999 Oct;146(4):373-90 [10550488] Addict Behav. 1999 Nov-Dec;24(6):749-67 [10628510] Acta Psychiatr Scand. 2000 Jan;101(1):11-20 [10674946] Clin Psychol Rev. 2000 Mar;20(2):235-53 [10721499] J Neurosci. 2000 Aug 15;20(16):6159-65 [10934265] Neuropsychologia. 2001;39(4):376-89 [11164876] Curr Opin Neurobiol. 2001 Apr;11(2):250-7 [11301247] Nat Rev Neurosci. 2001 Jun;2(6):417-24 [11389475] Neuropsychopharmacology. 2002 Jan;26(1):53-63 [11751032] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):523-8 [11756669] Curr Psychiatry Rep. 2002 Feb;4(1):25-9 [11814392] Dev Psychopathol. 2002 Winter;14(1):179-207 [11893092] Biol Psychiatry. 2002 Apr 15;51(8):605-11 [11955460] Neuropsychologia. 2002;40(10):1690-705 [11992657] J Cogn Neurosci. 2006 Sep;18(9):1586-94 [16989558] Am J Psychiatry. 2006 Nov;163(11):1969-77 [17074949] Drug Alcohol Depend. 2006 Dec 1;85(3):205-12 [16725282] J Neurosci. 2007 May 2;27(18):4839-49 [17475792] Mol Psychiatry. 2007 Jul;12(7):611, 691-702 [17245325] Neuroimage. 2007 Aug 15;37(2):579-88 [17604651] Neuroimage. 2003 Jul;19(3):1085-94 [12880834] J Neurosci. 2003 Aug 27;23(21):7839-43 [12944513] Neuroimage. 2003 Aug;19(4):1510-20 [12948707] Neuropsychologia. 2003;41(14):1959-66 [14572528] Science. 2004 Feb 20;303(5661):1208-10 [14976320] J Neurosci. 2004 Feb 25;24(8):1793-802 [14985419] Neuroimage. 2004 Mar;21(3):965-72 [15006663] Biol Psychiatry. 2004 Mar 15;55(6):594-602 [15013828] Biol Psychiatry. 2004 Mar 1;55(5):531-7 [15023582] Psychiatr Clin North Am. 2004 Jun;27(2):283-301 [15063998] Science. 2004 Oct 15;306(5695):443-7 [15486290] Cortex. 2004 Sep-Dec;40(4-5):593-604 [15505969] J Consult Clin Psychol. 1985 Dec;53(6):890-904 [4086689] J Neurol Neurosurg Psychiatry. 1986 Oct;49(10):1165-70 [3491181] Drug Alcohol Depend. 1990 Feb;25(1):97-104 [2323315] Ann Neurol. 1990 Dec;28(6):775-85 [2285264] Cognition. 1994 Apr-Jun;50(1-3):7-15 [8039375] Alcohol Clin Exp Res. 1995 Oct;19(5):1177-91 [8561288] Alcohol Clin Exp Res. 1995 Dec;19(6):1528-36 [8749822] Arch Gen Psychiatry. 1996 Nov;53(11):1033-9 [8911226] Arch Gen Psychiatry. 1997 Jan;54(1):62-8 [9006402] J Abnorm Psychol. 1998 Aug;107(3):363-74 [9715572] Psychol Med. 1998 Sep;28(5):1039-48 [9794011] Science. 1999 May 7;284(5416):970-4 [10320379] Alcohol Clin Exp Res. 2004 Oct;28(10):1577-86 [15597092] Psychopharmacology (Berl). 2006 Oct;188(3):364-73 [16953385] Brain Res Cogn Brain Res. 2005 Apr;23(1):119-36 [15795139] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.12.014 ER - TY - JOUR T1 - Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China. AN - 69293702; 18375961 AB - Biliary tract cancer, encompassing tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, is a rare but highly fatal malignancy. Obesity and gallstones, both related to insulin resistance, are linked to an elevated risk of biliary cancer. The peroxisome proliferator-activated receptors (PPARs) and the retinoid X receptors (RXRs), expressed in adipose tissue, play a key role in the regulation of obesity-related insulin sensitivity, thus genetic variants of these two receptor genes may be related to biliary cancer and stones. We examined the associations of seven single-nucleotide polymorphisms in the PPAR-gamma, PPAR-delta, RXR-alpha, RXR-beta and INS genes with biliary cancer and stones in a population-based case-control study in Shanghai, China. We included 237 gallbladder, 127 extrahepatic bile duct and 47 ampulla of Vater cancer cases, 895 stone cases and 786 population controls. Relative to individuals with the RXR-beta C51T (rs2076310) CC genotype, those having the TT genotype had a 1.6-fold risk for bile duct cancer [odds ratio (OR) = 1.67; 95% confidence interval (CI) = 0.99-2.84], with a more pronounced association among men (OR = 2.30; 95% CI = 1.14-4.65; P interaction = 0.07). This marker was also associated with a higher risk of gallstones among subjects with a higher body mass index (BMI) (>or=23 kg/m(2)) (OR = 1.80; 95% CI = 1.09-2.94), although the interaction with BMI was not statistically significant (P interaction = 0.28). No association was found between other variants and biliary cancers and stones. Results from this population-based study suggest that certain genetic variants involved in the regulation of obesity-related insulin sensitivity may increase susceptibility to bile duct cancer and gallstones. JF - Carcinogenesis AU - Chang, Shih-Chen AU - Rashid, Asif AU - Gao, Yu-Tang AU - Andreotti, Gabriella AU - Shen, Ming-Chang AU - Wang, Bin-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Sakoda, Lori C AU - Leitzmann, Michael F AU - Chen, Bingshu E AU - Rosenberg, Philip S AU - Chen, Jinbo AU - Chanock, Stephen J AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 944 EP - 948 VL - 29 IS - 5 KW - DNA, Neoplasm KW - 0 KW - Insulin KW - PPAR gamma KW - RARA protein, human KW - Receptors, Retinoic Acid KW - Retinoic Acid Receptor alpha KW - retinoic acid receptor beta KW - Index Medicus KW - Receptors, Retinoic Acid -- genetics KW - Bile Duct Neoplasms -- genetics KW - Odds Ratio KW - Bile Duct Neoplasms -- epidemiology KW - Humans KW - Aged KW - DNA, Neoplasm -- isolation & purification KW - Risk Factors KW - China -- epidemiology KW - Adult KW - Case-Control Studies KW - DNA, Neoplasm -- genetics KW - Incidence KW - Interviews as Topic KW - Middle Aged KW - Male KW - Female KW - PPAR gamma -- genetics KW - Gallstones -- epidemiology KW - Gallbladder Neoplasms -- epidemiology KW - Polymorphism, Genetic KW - Insulin -- genetics KW - Gallbladder Neoplasms -- genetics KW - Gallstones -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69293702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphism+of+genes+related+to+insulin+sensitivity+and+the+risk+of+biliary+tract+cancer+and+biliary+stone%3A+a+population-based+case-control+study+in+Shanghai%2C+China.&rft.au=Chang%2C+Shih-Chen%3BRashid%2C+Asif%3BGao%2C+Yu-Tang%3BAndreotti%2C+Gabriella%3BShen%2C+Ming-Chang%3BWang%2C+Bin-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BSakoda%2C+Lori+C%3BLeitzmann%2C+Michael+F%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BChen%2C+Jinbo%3BChanock%2C+Stephen+J%3BHsing%2C+Ann+W&rft.aulast=Chang&rft.aufirst=Shih-Chen&rft.date=2008-05-01&rft.volume=29&rft.issue=5&rft.spage=944&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-01 N1 - Date created - 2008-07-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hepatology. 2000 Feb;31(2):299-303 [10655249] Nephron Clin Pract. 2007;106(4):c162-8 [17596725] J Clin Invest. 2001 Oct;108(7):1001-13 [11581301] Tissue Antigens. 2001 Jul;58(1):24-9 [11580852] Lancet. 2002 Nov 2;360(9343):1410-8 [12424006] Br J Cancer. 2003 Jan 27;88(2):263-9 [12610512] Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S17-21 [14704738] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] Br Med J (Clin Res Ed). 1984 Sep 1;289(6444):521-5 [6432171] Cancer. 1986 Oct 15;58(8 Suppl):1826-9 [3756807] Hepatology. 1987 Sep-Oct;7(5):913-7 [3653855] Gut. 1990 Mar;31(3):344-7 [2182400] Am J Epidemiol. 1990 Aug;132(2):327-35 [2196792] Cancer Causes Control. 1992 Mar;3(2):145-51 [1562704] Int J Cancer. 1992 Jul 9;51(5):707-11 [1612778] Ann Hum Genet. 1993 Jul;57(Pt 3):203-9 [8257090] Int J Cancer. 1994 Apr 15;57(2):146-53 [8157350] Cancer Causes Control. 1994 May;5(3):267-72 [8061176] Cancer Surv. 1994;19-20:125-37 [7534623] Br J Cancer. 1995 Dec;72(6):1556-8 [8519677] Hepatology. 1997 Apr;25(4):787-90 [9096577] J Clin Invest. 1997 May 15;99(10):2416-22 [9153284] Int J Cancer. 1998 Jan 30;75(3):368-70 [9455795] Indian J Cancer. 2004 Oct-Dec;41(4):147-51 [15659866] Carcinogenesis. 2005 Mar;26(3):579-85 [15564289] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1315-8 [15894693] Cancer Sci. 2005 Aug;96(8):507-12 [16108832] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3444-9 [16492734] Int J Cancer. 2006 Jun 15;118(12):3089-94 [16395699] Carcinogenesis. 2006 Jun;27(6):1251-6 [16361272] J Hepatol. 2006 Aug;45(2):299-305 [16516330] Diabet Med. 2006 Dec;23(12):1307-12 [17116180] Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):923-8 [17272748] Gut. 2000 Jul;47(1):144-7 [10861277] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn025 ER - TY - JOUR T1 - Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration? AN - 69200859; 18470306 AB - Parkinson disease (PD), a chronic neurodegenerative disease, has been proposed to be a multifactorial disorder resulting from a combination of environmental mechanisms (chemical, infectious, and traumatic), aging, and genetic deficits. Microglial activation is important in the pathogenesis of PD. We investigated dopaminergic (DA) neurotoxicity and the underlying mechanisms of formyl-methionyl-leucyl-phenylalanine (fMLP), a bacteria-derived peptide, in relation to PD. We measured DA neurotoxicity using a DA uptake assay and immunocytochemical staining (ICC) in primary mesencephalic cultures from rodents. Microglial activation was observed via ICC, flow cytometry, and superoxide measurement. fMLP can cause selective DA neuronal loss at concentrations as low as 10(-13) M. Further, fMLP (10(-13) M) led to a significant reduction in DA uptake capacity in neuron/glia (N/G) cultures, but not in microglia-depleted cultures, indicating an indispensable role of microglia in fMLP-induced neurotoxicity. Using ICC of a specific microglial marker, OX42, we observed morphologic changes in activated microglia after fMLP treatment. Microglial activation after fMLP treatment was confirmed by flow cytometry analysis of major histocompatibility antigen class II expression on a microglia HAPI cell line. Mechanistic studies revealed that fMLP (10(-13) M)-induced increase in the production of extracellular superoxide from microglia is critical in mediating fMLP-elicited neurotoxicity. Pharmacologic inhibition of NADPH oxidase (PHOX) with diphenylene-iodonium or apocynin abolished the DA neurotoxicity of fMLP. N/G cultures from PHOX-deficient (gp91PHOX-/ -) mice were also insensitive to fMLP-induced DA neurotoxicity. fMLP (10(-13) M) induces DA neurotoxicity through activation of microglial PHOX and subsequent production of superoxide, suggesting a role of fMLP in the central nervous system inflammatory process. JF - Environmental health perspectives AU - Gao, Xi AU - Hu, Xiaoming AU - Qian, Li AU - Yang, Sufen AU - Zhang, Wei AU - Zhang, Dan AU - Wu, Xuefei AU - Fraser, Alison AU - Wilson, Belinda AU - Flood, Patrick M AU - Block, Michelle AU - Hong, Jau-Shyong AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 593 EP - 598 VL - 116 IS - 5 SN - 0091-6765, 0091-6765 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - inflammation KW - microglia KW - neurotoxicity KW - fMLP KW - NADPH oxidase KW - NADPH Oxidase -- metabolism KW - Animals KW - Neurons -- metabolism KW - Enzyme Activation KW - Neurons -- drug effects KW - Mice KW - Mice, Knockout KW - Pregnancy KW - Rats KW - Rats, Inbred F344 KW - Cells, Cultured KW - Oxidative Stress KW - Mice, Inbred C57BL KW - Female KW - Parkinson Disease -- etiology KW - Neurodegenerative Diseases -- chemically induced KW - Microglia -- enzymology KW - Central Nervous System Infections -- metabolism KW - Central Nervous System Infections -- etiology KW - Neurodegenerative Diseases -- metabolism KW - Neurodegenerative Diseases -- pathology KW - Dopamine -- metabolism KW - N-Formylmethionine Leucyl-Phenylalanine -- toxicity KW - Microglia -- drug effects KW - Central Nervous System Infections -- pathology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69200859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Formyl-methionyl-leucyl-phenylalanine-induced+dopaminergic+neurotoxicity+via+microglial+activation%3A+a+mediator+between+peripheral+infection+and+neurodegeneration%3F&rft.au=Gao%2C+Xi%3BHu%2C+Xiaoming%3BQian%2C+Li%3BYang%2C+Sufen%3BZhang%2C+Wei%3BZhang%2C+Dan%3BWu%2C+Xuefei%3BFraser%2C+Alison%3BWilson%2C+Belinda%3BFlood%2C+Patrick+M%3BBlock%2C+Michelle%3BHong%2C+Jau-Shyong&rft.aulast=Gao&rft.aufirst=Xi&rft.date=2008-05-01&rft.volume=116&rft.issue=5&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-25 N1 - Date created - 2008-05-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Histol Histopathol. 2006 Jun;21(6):673-8 [16528677] Blood. 1996 Jul 15;88(2):690-6 [8695817] J Biochem. 2006 Nov;140(5):739-45 [17030506] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] J Immunol. 2007 Feb 1;178(3):1759-66 [17237425] Glia. 2007 Apr 1;55(5):453-62 [17203472] Brain Res. 2007 Mar 23;1138:196-202 [17275793] J Am Acad Nurse Pract. 2007 Apr;19(4):179-97 [17430539] Neurosci Lett. 1996 Jun 14;211(1):13-6 [8809836] Ann Neurol. 1998 Sep;44(3 Suppl 1):S115-20 [9749582] Blood. 1999 Mar 1;93(5):1464-76 [10029572] Immunopharmacol Immunotoxicol. 1999 Aug;21(3):397-419 [10466071] J Exp Med. 1999 Sep 6;190(5):741-7 [10477558] Ann Neurol. 2005 Feb;57(2):176-9 [15668963] FASEB J. 2005 Apr;19(6):550-7 [15791005] FASEB J. 2006 Feb;20(2):251-8 [16449797] J Neural Transm Suppl. 2007;(72):113-20 [17982884] Brain Res Rev. 2007 Nov;56(1):119-47 [17659349] J Biol Chem. 2008 Mar 21;283(12):7983-93 [18160398] Br J Pharmacol. 1998 Nov;125(5):1109-14 [9846652] J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] Neurobiol Aging. 2000 May-Jun;21(3):463-73 [10858596] Immunol Rev. 2000 Oct;177:185-94 [11138775] J Pharmacol Exp Ther. 2001 Sep;298(3):1133-41 [11504811] Neural Plast. 2001;8(1-2):99-110 [11530892] J Immunol. 2002 Jan 1;168(1):434-42 [11751990] Neuroscience. 2002;112(1):7-11 [12044467] J Neurochem. 2002 Jun;81(6):1285-97 [12068076] Ann N Y Acad Sci. 2002 May;962:318-31 [12076984] Neurobiol Dis. 2002 Aug;10(3):366-77 [12270697] J Neurochem. 2002 Nov;83(4):973-83 [12421370] Nat Rev Neurosci. 2003 Feb;4(2):103-12 [12563281] Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8 [12666096] Scand J Immunol. 2004 Jan;59(1):25-33 [14723618] Immunology. 2004 Jun;112(2):201-10 [15147563] Drugs. 2004;64(19):2143-57 [15456332] Biochem Biophys Res Commun. 1985 Apr 16;128(1):297-304 [2985075] Neurology. 1988 Aug;38(8):1285-91 [3399080] J Neurosci Res. 1990 Sep;27(1):36-42 [2254955] Blood. 1993 Jul 15;82(2):633-40 [8329716] Nature. 1993 Aug 12;364(6438):584 [8350919] Ann Neurol. 1994;36 Suppl:S25-8 [8017885] J Pharmacol Exp Ther. 2006 Nov;319(2):595-603 [16891616] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.11031 ER - TY - JOUR T1 - Defining targets for investigating the pharmacogenomics of adverse drug reactions to antifungal agents. AN - 69198563; 18466103 AB - Adverse drug reactions (ADRs) associated with antifungal therapy are major problems in patients with invasive fungal infections. Whether by clinical history or patterns of genetic variation, the identification of patients at risk for ADRs should result in improved outcomes while minimizing deleterious side effects. A major contributing factor to ADRs with antifungal agents relates to drug distribution, metabolism and excretion. Genetic variation in key genes can alter the structure and expression of genes and gene products (e.g., proteins). Thus far, the effort has focused on identifying polymorphisms with either empirical or predicted in silico functional consequences; the best candidate genes encode phase I and II drug-metabolizing enzymes (e.g., CYP2C19 and N-acetyltransferase), plasma proteins (albumin and lipoproteins) and drug transporters (P-glycoprotein and multidrug resistance proteins), which can affect the disposition of antifungal agents, eventually leading to dose-dependent (type A) toxicity. Less is known regarding the key genes that interact with antifungal agents, resulting in idiosyncratic (type B) ADRs. The possible role of certain gene products and genetic polymorphisms in the toxicities of antifungal agents are discussed in this review. The preliminary data address the following: low-density lipoproteins and cholesteryl ester transfer protein in amphotericin B renal toxicity; toll-like receptor 1 and 2 in amphotericin B infusion-related ADRs; phosphodiesterase 6 in voriconazole visual adverse events; flavin-containing monooxygenase, glutathione transferases and multidrug resistance proteins 1 and 2 in ketoconazole and terbinafine hepatotoxicity; CYP enzymes and P-glycoprotein in drug interactions between azoles and coadministered medications; multidrug resistance proteins 8 and 9 on 5-flucytosine bone marrow toxicity; and mast cell activation in caspofungin histamine release. This will focus on high-priority candidate genes, which could provide a starting point for molecular studies to elucidate the potential mechanisms for understanding toxicity associated with antifungal drugs as well as identifying candidate genes for large population prospective genetic association studies. JF - Pharmacogenomics AU - Meletiadis, Joseph AU - Chanock, Stephen AU - Walsh, Thomas J AD - National Cancer Institute, National Institutes of Health, Pediatric Oncology Branch, Bethesda, MD 20814, USA. jmeletiadis@med.uoa.gr Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 561 EP - 584 VL - 9 IS - 5 KW - Antifungal Agents KW - 0 KW - Index Medicus KW - Polymorphism, Genetic -- drug effects KW - Animals KW - Polymorphism, Genetic -- genetics KW - Humans KW - Antifungal Agents -- adverse effects KW - Adverse Drug Reaction Reporting Systems -- trends KW - Drug Delivery Systems -- methods KW - Antifungal Agents -- administration & dosage KW - Pharmacogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69198563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=Defining+targets+for+investigating+the+pharmacogenomics+of+adverse+drug+reactions+to+antifungal+agents.&rft.au=Meletiadis%2C+Joseph%3BChanock%2C+Stephen%3BWalsh%2C+Thomas+J&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2008-05-01&rft.volume=9&rft.issue=5&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=1744-8042&rft_id=info:doi/10.2217%2F14622416.9.5.561 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2217/14622416.9.5.561 ER - TY - JOUR T1 - Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation. AN - 69190250; 18344406 AB - The packaging of eukaryotic DNA into chromatin is likely to be crucial for the maintenance of genomic integrity. Histone acetylation and deacetylation, which alter chromatin accessibility, have been implicated in DNA damage tolerance. Here we show that Schizosaccharomyces pombe Hst4, a homolog of histone deacetylase Sir2, participates in S-phase-specific DNA damage tolerance. Hst4 was essential for the survival of cells exposed to the genotoxic agent methyl methanesulfonate (MMS) as well as for cells lacking components of the DNA damage checkpoint pathway. It was required for the deacetylation of histone H3 core domain residue lysine 56, since a strain with a point mutation of its catalytic domain was unable to deacetylate this residue in vivo. Hst4 regulated the acetylation of H3 K56 and was itself cell cycle regulated. We also show that MMS treatment resulted in increased acetylation of histone H3 lysine 56 in wild-type cells and hst4Delta mutants had constitutively elevated levels of histone H3 K56 acetylation. Interestingly, the level of expression of Hst4 decreased upon MMS treatment, suggesting that the cell regulates access to the site of DNA damage by changing the level of this protein. Furthermore, we find that the phenotypes of both K56Q and K56R mutants of histone H3 were similar to those of hst4Delta mutants, suggesting that proper regulation of histone acetylation is important for DNA integrity. We propose that Hst4 is a deacetylase involved in the restoration of chromatin structure following the S phase of cell cycle and DNA damage response. JF - Eukaryotic cell AU - Haldar, Devyani AU - Kamakaka, Rohinton T AD - Unit on Chromatin and Transcription, NICHD/NIH, 18 Library Dr., Bethesda, Maryland 20892, USA. devyanih@ilsresearch.org Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 800 EP - 813 VL - 7 IS - 5 KW - Cell Cycle Proteins KW - 0 KW - Codon, Nonsense KW - Histone Deacetylase Inhibitors KW - Histones KW - Mutagens KW - Schizosaccharomyces pombe Proteins KW - Hst4 protein, S pombe KW - EC 3.5.1.- KW - Histone Deacetylases KW - EC 3.5.1.98 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Phenotype KW - DNA Repair Enzymes -- metabolism KW - Acetylation KW - Ultraviolet Rays KW - Protein Processing, Post-Translational KW - Mutagens -- pharmacology KW - Cell Cycle KW - Cell Cycle Proteins -- metabolism KW - Gene Expression Regulation, Fungal KW - Schizosaccharomyces -- cytology KW - Schizosaccharomyces pombe Proteins -- genetics KW - DNA Damage KW - Schizosaccharomyces -- metabolism KW - Schizosaccharomyces pombe Proteins -- antagonists & inhibitors KW - Lysine -- metabolism KW - Schizosaccharomyces -- growth & development KW - Schizosaccharomyces -- genetics KW - Schizosaccharomyces pombe Proteins -- metabolism KW - Histones -- metabolism KW - Histone Deacetylases -- metabolism KW - Histones -- antagonists & inhibitors KW - Histone Deacetylases -- genetics KW - Histones -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69190250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eukaryotic+cell&rft.atitle=Schizosaccharomyces+pombe+Hst4+functions+in+DNA+damage+response+by+regulating+histone+H3+K56+acetylation.&rft.au=Haldar%2C+Devyani%3BKamakaka%2C+Rohinton+T&rft.aulast=Haldar&rft.aufirst=Devyani&rft.date=2008-05-01&rft.volume=7&rft.issue=5&rft.spage=800&rft.isbn=&rft.btitle=&rft.title=Eukaryotic+cell&rft.issn=1535-9786&rft_id=info:doi/10.1128%2FEC.00379-07 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-16 N1 - Date created - 2008-05-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Jan 6;403(6765):41-5 [10638745] J Biol Chem. 2007 May 18;282(20):15040-7 [17369611] FEBS Lett. 2000 Jun 30;476(1-2):73-7 [10878254] Yeast. 2001 May;18(7):657-62 [11329175] Cell. 2001 Apr 20;105(2):269-79 [11336676] Nat Rev Mol Cell Biol. 2001 Jun;2(6):422-32 [11389466] EMBO J. 2001 Jun 15;20(12):3187-96 [11406595] Mutat Res. 2001 Jul 12;486(2):89-97 [11425514] EMBO J. 2001 Aug 15;20(16):4522-35 [11500379] Prog Nucleic Acid Res Mol Biol. 2001;68:41-54 [11554312] Mol Cell Biol. 2001 Oct;21(20):6782-95 [11564863] Cell. 2001 Oct 19;107(2):137-48 [11672522] Mol Cell. 2002 Feb;9(2):265-77 [11864601] J Biol Chem. 2002 Apr 5;277(14):11853-8 [11805113] Mol Biol Cell. 2002 Apr;13(4):1427-38 [11950950] Curr Biol. 2002 Jun 25;12(12):1052-8 [12123582] Nature. 2002 Sep 26;419(6905):411-5 [12353039] Biochem J. 2003 Mar 15;370(Pt 3):737-49 [12429021] Nat Rev Mol Cell Biol. 2003 Apr;4(4):276-84 [12671650] Mol Cell. 2003 May;11(5):1323-36 [12769855] Curr Biol. 2003 Jul 15;13(14):1240-6 [12867036] Curr Biol. 2003 Oct 14;13(20):1748-57 [14561399] Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1644-9 [14711989] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):158-64 [15020056] Genes Dev. 2004 Mar 15;18(6):602-16 [15075289] Genome Biol. 2004;5(5):224 [15128440] Eur J Biochem. 2004 Jun;271(12):2335-49 [15182349] Mutat Res. 1989 Apr;211(2):243-57 [2494441] Methods Enzymol. 1991;194:795-823 [2005825] Genes Dev. 1995 Jul 15;9(14):1716-27 [7622036] Genes Dev. 1995 Dec 1;9(23):2888-902 [7498786] Nature. 1997 Sep 18;389(6648):251-60 [9305837] Cell. 1997 Dec 26;91(7):1021-32 [9428524] Yeast. 1998 Jul;14(10):943-51 [9717240] Curr Opin Cell Biol. 1998 Dec;10(6):749-58 [9914174] Biochimie. 1999 Jan-Feb;81(1-2):15-25 [10214906] Biochimie. 1999 Jan-Feb;81(1-2):173-81 [10214922] Mol Biol Cell. 1999 Oct;10(10):3171-86 [10512858] Curr Opin Cell Biol. 2004 Dec;16(6):629-33 [15530773] Science. 2004 Dec 17;306(5704):2084-7 [15528408] Genetics. 2005 Mar;169(3):1243-60 [15545655] Cell. 2005 May 6;121(3):375-85 [15882620] J Biol Chem. 2005 Jul 15;280(28):25949-52 [15888442] Nature. 2005 Jul 14;436(7048):294-8 [16015338] Mol Cell Biol. 2005 Nov;25(22):10060-70 [16260619] Nat Rev Mol Cell Biol. 2005 Oct;6(10):757-65 [16167054] Yeast. 2005 Dec;22(16):1307-14 [16358314] Cell. 2006 Jan 27;124(2):315-29 [16439206] Mol Cell. 2006 Jul 7;23(1):109-19 [16818235] Curr Biol. 2006 Jul 11;16(13):1280-9 [16815704] Cell Cycle. 2006 Sep;5(17):1940-5 [16940754] Cell Cycle. 2006 Nov;5(22):2561-5 [17106263] Cell Cycle. 2006 Nov;5(22):2602-8 [17172838] Science. 2007 Feb 2;315(5812):649-52 [17272722] Science. 2007 Feb 2;315(5812):653-5 [17272723] Mol Cell. 2007 Mar 9;25(5):703-12 [17320445] Nature. 2000 Feb 17;403(6771):795-800 [10693811] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/EC.00379-07 ER - TY - JOUR T1 - Cardiotoxicity and incidence of brain metastases after adjuvant trastuzumab for early breast cancer: the dark side of the moon? A meta-analysis of the randomized trials. AN - 69184256; 17638068 AB - In five randomized clinical trials (RCTs), adjuvant trastuzumab (T) for early stage breast cancer with human epidermal growth-factor receptor-2 over-expression/gene-amplification has shown to decrease the risk of both recurrence and death. The issue regarding the long-term safety profile of such drug is still open; in particular, questions remain about long-term cardiotoxicity, and specific patterns of relapse such as brain metastases (BM). In order to quantify the magnitude of these two risks, and then balance those with the survival outcome, a literature-based meta-analysis was performed. All phase III trials were considered eligible. A literature-based meta-analysis was accomplished, and event-based relative risk ratios with 95% confidence interval were derived. A fixed- and a random-effect model according to the inverse variance and the Mantel-Haenzel method were applied. Heterogeneity test was applied as well. Absolute differences (AD) and the Number of patients Needed to Treat or to Harm (NNT/NNH) were calculated. Safety end-points were: (1) Chronic Heart Failure (CHF) grade III-IV rate, (2) Significant reduction of left-ventricular-ejection-fraction (L-FEV) rate and (3) BM rate. In order to quantify the magnitude of the significant benefit already found in the original RCTs, Efficacy end-points were: (1) disease-free survival (DFS) and (2) overall survival (OS). Five RCTs were gathered (11,187 patients); at an average 2-years follow-up, all data was available for the safety and efficacy end-points, while three RCTs reported results for BM analysis (6,738 patients). When considering RCTs with trastuzumab administered for 1 year, a significant increased risk of grade III-IV Congestive Heart Failure (CHF) was found in the T-arm, with an AD of 1.61% (p < 0.00001), which translates into 62 treated patients required to harm one (NNH). When considering the asymptomatic L-FEV reduction, a significant increased risk of grade significant L-FEV reduction was found in the T-arm, although significantly heterogeneous, with an AD of 7.20% (p < 0.00001), which translates into 14 NNH. The incidence of BM was significantly higher in the T-arm, without significant heterogeneity, with an AD of 0.62 (p = 0.033), which translates into 161 NNH. The DFS, DDFS, and OS were significantly better in the T-arm, with an AD of 6.00, 4.80 and 1.96%, which translates into 16, 21 and 51 NNT, respectively. The overall outcome results show that trastuzumab is one of the most important discoveries in oncology. Nevertheless, the biological activity of trastuzumab needs to be investigated more extensively to explore both long-term safety and specific relapse patterns. JF - Breast cancer research and treatment AU - Bria, Emilio AU - Cuppone, Federica AU - Fornier, Monica AU - Nisticò, Cecilia AU - Carlini, Paolo AU - Milella, Michele AU - Sperduti, Isabella AU - Terzoli, Edmondo AU - Cognetti, Francesco AU - Giannarelli, Diana AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. emiliobria@yahoo.it Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 231 EP - 239 VL - 109 IS - 2 SN - 0167-6806, 0167-6806 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Trastuzumab KW - P188ANX8CK KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Radiotherapy, Adjuvant KW - Humans KW - Incidence KW - Heart -- drug effects KW - Female KW - Risk Assessment KW - Breast Neoplasms -- drug therapy KW - Brain Neoplasms -- epidemiology KW - Heart Diseases -- chemically induced KW - Antibodies, Monoclonal -- adverse effects KW - Brain Neoplasms -- secondary KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69184256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Cardiotoxicity+and+incidence+of+brain+metastases+after+adjuvant+trastuzumab+for+early+breast+cancer%3A+the+dark+side+of+the+moon%3F+A+meta-analysis+of+the+randomized+trials.&rft.au=Bria%2C+Emilio%3BCuppone%2C+Federica%3BFornier%2C+Monica%3BNistic%C3%B2%2C+Cecilia%3BCarlini%2C+Paolo%3BMilella%2C+Michele%3BSperduti%2C+Isabella%3BTerzoli%2C+Edmondo%3BCognetti%2C+Francesco%3BGiannarelli%2C+Diana&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2008-05-01&rft.volume=109&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-15 N1 - Date created - 2008-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt. AN - 69173251; 18396042 AB - First synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt is reported. JF - Bioorganic & medicinal chemistry letters AU - Risbood, Prabhakar A AU - Kane, Charles T AU - Hossain, Md Tafazzal AU - Vadapalli, Sudhakarrao AU - Chadda, Satish K AD - Drug Synthesis and Chemistry Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. risboodp@mail.nih.gov Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 2957 EP - 2958 VL - 18 IS - 9 KW - Antimetabolites, Antineoplastic KW - 0 KW - Polyphosphates KW - Quaternary Ammonium Compounds KW - Salts KW - Tromethamine KW - 023C2WHX2V KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - triphosphoric acid KW - NU43IAG5BC KW - Index Medicus KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Models, Chemical KW - Chromatography, Thin Layer KW - Chromatography, High Pressure Liquid KW - Polyphosphates -- pharmacology KW - Deoxycytidine -- analogs & derivatives KW - Polyphosphates -- chemical synthesis KW - Deoxycytidine -- chemical synthesis KW - Salts -- chemistry KW - Quaternary Ammonium Compounds -- chemistry KW - Antimetabolites, Antineoplastic -- chemical synthesis KW - Tromethamine -- pharmacology KW - Antimetabolites, Antineoplastic -- pharmacology KW - Salts -- pharmacology KW - Quaternary Ammonium Compounds -- pharmacology KW - Tromethamine -- chemistry KW - Deoxycytidine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69173251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.atitle=Synthesis+of+gemcitabine+triphosphate+%28dFdCTP%29+as+a+tris%28triethylammonium%29+salt.&rft.au=Risbood%2C+Prabhakar+A%3BKane%2C+Charles+T%3BHossain%2C+Md+Tafazzal%3BVadapalli%2C+Sudhakarrao%3BChadda%2C+Satish+K&rft.aulast=Risbood&rft.aufirst=Prabhakar&rft.date=2008-05-01&rft.volume=18&rft.issue=9&rft.spage=2957&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry+letters&rft.issn=1464-3405&rft_id=info:doi/10.1016%2Fj.bmcl.2008.03.063 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-15 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mass Spectrom. 2006 Dec;41(12):1633-42 [17117372] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmcl.2008.03.063 ER - TY - JOUR T1 - Office-based management of urticaria. AN - 69168733; 18456030 AB - Urticaria is a common pruritic skin disorder that is often seen in the office and varies in severity and chronicity. The etiologic cause is frequently not identifiable. Urticaria may be associated with physical factors and triggers, including foods or medications. A significant percentage of patients with chronic urticaria have circulating autoantibodies directed toward immunoglobulin-E or the high-affinity receptor for immunoglobulin-E (FcepsilonRI), or have antithyroid antibodies that might play a role in the activation of the final common pathway in urticaria: mast cell activation and degranulation. Management begins with a careful investigation and elimination of eliciting factors when identified, followed by treatment of underlying disease. Antihistamines are the current mainstay of pharmacotherapy for urticaria, which provide symptomatic relief in most cases. In severe cases, corticosteroids, hydroxychloroquine sulfate (Plaquenil; Sanofi-Synthelabo, New York, NY), and immunosuppressive agents, including cyclosporin, are sometimes used by specialists. JF - The American journal of medicine AU - Komarow, Hirsh D AU - Metcalfe, Dean D AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1894, USA. komarowh@niaid.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 379 EP - 384 VL - 121 IS - 5 KW - Adrenal Cortex Hormones KW - 0 KW - Histamine H1 Antagonists KW - Immunosuppressive Agents KW - Leukotriene Antagonists KW - Abridged Index Medicus KW - Index Medicus KW - Food Hypersensitivity KW - Adrenal Cortex Hormones -- therapeutic use KW - Humans KW - Leukotriene Antagonists -- therapeutic use KW - Immunosuppressive Agents -- therapeutic use KW - Drug Hypersensitivity KW - Histamine H1 Antagonists -- therapeutic use KW - Urticaria -- diagnosis KW - Urticaria -- chemically induced KW - Urticaria -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69168733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Office-based+management+of+urticaria.&rft.au=Komarow%2C+Hirsh+D%3BMetcalfe%2C+Dean+D&rft.aulast=Komarow&rft.aufirst=Hirsh&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=1555-7162&rft_id=info:doi/10.1016%2Fj.amjmed.2007.10.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.amjmed.2007.10.039 ER - TY - JOUR T1 - Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. AN - 69167601; 18451145 AB - Nutlin-3, an MDM2 inhibitor, activates p53, resulting in several types of cancer cells undergoing apoptosis. Although p53 is mutated or deleted in approximately 50% of all cancers, p53 is still functionally active in the other 50%. Consequently, nutlin-3 and similar drugs could be candidates for neoadjuvant therapy in cancers with a functional p53. Cellular senescence is also a phenotype induced by p53 activation and plays a critical role in protecting against tumor development. In this report, we found that nutlin-3a can induce senescence in normal human fibroblasts. Nutlin-3a activated and repressed a large number of p53-dependent genes, including those encoding microRNAs. mir-34a, mir-34b, and mir-34c, which have recently been shown to be downstream effectors of p53-mediated senescence, were up-regulated, and inhibitor of growth 2 (ING2) expression was suppressed by nutlin-3a treatment. Two candidates for a p53-DNA binding consensus sequence were found in the ING2 promoter regulatory region; thus, we performed chromatin immunoprecipitation and electrophoretic mobility shift assays and confirmed p53 binding directly to those sites. In addition, the luciferase activity of a construct containing the ING2 regulatory region was repressed after p53 activation. Antisense knockdown of ING2 induces p53-independent senescence, whereas overexpression of ING2 induces p53-dependent senescence. Taken together, we conclude that nutlin-3a induces senescence through p53 activation in normal human fibroblasts, and p53-mediated mir34a, mir34b, and mir34c up-regulation and ING2 down-regulation may be involved in the senescence pathway. JF - Cancer research AU - Kumamoto, Kensuke AU - Spillare, Elisa A AU - Fujita, Kaori AU - Horikawa, Izumi AU - Yamashita, Taro AU - Appella, Ettore AU - Nagashima, Makoto AU - Takenoshita, Seiichi AU - Yokota, Jun AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4258, USA. Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 3193 EP - 3203 VL - 68 IS - 9 KW - Homeodomain Proteins KW - 0 KW - ING2 protein, human KW - Imidazoles KW - MIRN34 microRNA, human KW - MicroRNAs KW - Piperazines KW - Receptors, Cytoplasmic and Nuclear KW - Tumor Suppressor Protein p53 KW - Tumor Suppressor Proteins KW - nutlin 3 KW - 53IA0V845C KW - Index Medicus KW - Fibroblasts -- drug effects KW - Promoter Regions, Genetic KW - Base Sequence KW - Down-Regulation KW - Cells, Cultured KW - Protein Binding -- drug effects KW - Humans KW - Gene Expression Regulation KW - Up-Regulation KW - HCT116 Cells KW - Fibroblasts -- physiology KW - Tumor Suppressor Protein p53 -- physiology KW - Imidazoles -- pharmacology KW - Homeodomain Proteins -- genetics KW - MicroRNAs -- genetics KW - Tumor Suppressor Proteins -- genetics KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Tumor Suppressor Protein p53 -- genetics KW - Piperazines -- pharmacology KW - Tumor Suppressor Protein p53 -- metabolism KW - Cell Aging -- genetics KW - Cell Aging -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69167601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Nutlin-3a+activates+p53+to+both+down-regulate+inhibitor+of+growth+2+and+up-regulate+mir-34a%2C+mir-34b%2C+and+mir-34c+expression%2C+and+induce+senescence.&rft.au=Kumamoto%2C+Kensuke%3BSpillare%2C+Elisa+A%3BFujita%2C+Kaori%3BHorikawa%2C+Izumi%3BYamashita%2C+Taro%3BAppella%2C+Ettore%3BNagashima%2C+Makoto%3BTakenoshita%2C+Seiichi%3BYokota%2C+Jun%3BHarris%2C+Curtis+C&rft.aulast=Kumamoto&rft.aufirst=Kensuke&rft.date=2008-05-01&rft.volume=68&rft.issue=9&rft.spage=3193&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-07-2780 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 1998 Mar 20;92(6):725-34 [9529249] Mol Cell. 2007 Jun 8;26(5):745-52 [17540599] Curr Biol. 1999 Sep 9;9(17):939-45 [10508581] Genes Dev. 1999 Oct 1;13(19):2490-501 [10521394] Exp Cell Res. 1961 Dec;25:585-621 [13905658] Mol Biol Evol. 2005 Jan;22(1):104-16 [15356280] J Biol Chem. 2004 Dec 17;279(51):53015-22 [15471885] Cell. 2005 Jan 28;120(2):169-81 [15680324] Oncogene. 2005 Mar 3;24(10):1738-48 [15674334] J Med Chem. 2005 Jul 14;48(14):4491-9 [15999986] Mol Cell Biol. 2005 Aug;25(15):6639-48 [16024799] Nature. 2005 Aug 4;436(7051):642 [16079833] Cancer Res. 2005 Nov 15;65(22):10255-64 [16288013] J Biol Chem. 2000 Mar 31;275(13):9278-83 [10734067] Clin Cancer Res. 2000 Apr;6(4):1239-47 [10778946] Eur J Biochem. 2001 May;268(10):2784-91 [11358493] J Biol Chem. 2001 Aug 10;276(32):29729-39 [11375983] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9671-6 [11481424] Nature. 2002 Sep 26;419(6905):407-11 [12353038] Cell Death Differ. 2003 Apr;10(4):404-8 [12719716] Oncogene. 2003 Jun 5;22(23):3645-54 [12789273] Cancer Biol Ther. 2003 Jul-Aug;2(4):406-15 [14508115] Cancer Res. 2003 Sep 15;63(18):5785-92 [14522900] Science. 2004 Feb 6;303(5659):844-8 [14704432] Oncogene. 2004 May 27;23(25):4477-87 [15064747] Nature. 1992 Jul 2;358(6381):80-3 [1614537] Exp Cell Res. 1995 Apr;217(2):205-16 [7698220] Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9363-7 [7568133] Mech Ageing Dev. 1995 Jul 14;81(2-3):139-57 [8569279] Cell. 1997 Mar 7;88(5):593-602 [9054499] Nature. 1997 May 15;387(6630):296-9 [9153395] Endocrinology. 1998 Mar;139(3):1101-7 [9492043] Cell. 1998 Mar 20;92(6):713-23 [9529248] Mol Cell. 2006 Jan 6;21(1):51-64 [16387653] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93 [16443686] Cancer Res. 2006 Mar 15;66(6):2881-4 [16540631] Rejuvenation Res. 2006 Spring;9(1):69-76 [16608399] Blood. 2006 May 15;107(10):4109-14 [16439685] Nature. 2006 Jul 6;442(7098):96-9 [16728974] Nature. 2006 Jul 6;442(7098):100-3 [16728977] Nat Cell Biol. 2006 Aug;8(8):877-84 [16862142] Trends Mol Med. 2007 Jan;13(1):23-31 [17126603] Mol Cell. 2007 Jan 12;25(1):15-30 [17218268] Cancer Res. 2007 Jan 15;67(2):450-4 [17234751] Nat Rev Mol Cell Biol. 2007 Apr;8(4):275-83 [17380161] Oncogene. 2007 May 24;26(24):3473-81 [17146434] Mol Cell. 2007 Jun 8;26(5):731-43 [17540598] Nature. 2007 Jun 28;447(7148):1130-4 [17554337] Cell Cycle. 2007 Jul 1;6(13):1586-93 [17554199] Cancer Res. 2007 Aug 1;67(15):7350-7 [17671205] Biochem J. 1999 Aug 15;342 ( Pt 1):133-41 [10432310] Oncogene. 1998 Sep 3;17(9):1089-96 [9764819] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-07-2780 ER - TY - JOUR T1 - Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. AN - 69165835; 18162486 AB - Cyclooxygenase (COX) -1 and -2 metabolize arachidonic acid to prostanoids and reactive oxygen species, major players in the neuroinflammatory process. While most reports have focused on the inducible isoform, COX-2, the contribution of COX-1 to the inflammatory response is unclear. In the present study, the contribution of COX-1 in the neuroinflammatory response to intracerebroventricular lipopolysaccharide (LPS) was investigated using COX-1 deficient (COX-1(-/-)) mice or wild-type (COX-1(+/+)) mice pretreated with SC-560, a selective COX-1 inhibitor. Twenty-four hours after lipopolysaccharide (LPS) injection, COX-1(-/-) mice showed decreased protein oxidation and LPS-induced neuronal damage in the hippocampus compared with COX-1(+/+) mice. COX-1(-/-) mice showed a significant reduction of microglial activation, proinflammatory mediators, and expression of COX-2, inducible NOS, and NADPH oxidase. The transcriptional down-regulation of cytokines and other inflammatory markers in COX-1(-/-) mice was mediated by a reduced activation of NF-kappaB and signal transducer and activator of transcription 3. Administration of SC-560 prior to LPS injection also attenuated the neuroinflammatory response by decreasing brain levels of prostaglandin (PG)E(2), PGD(2), PGF(2alpha), and thromboxane B(2), as well as the expression of proinflammatory cytokines and chemokine. These findings suggest that COX-1 plays a previously unrecognized role in neuroinflammatory damage. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Choi, Sang-Ho AU - Langenbach, Robert AU - Bosetti, Francesca AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1491 EP - 1501 VL - 22 IS - 5 KW - Cyclooxygenase Inhibitors KW - 0 KW - Lipopolysaccharides KW - Membrane Glycoproteins KW - Pyrazoles KW - SC 560 KW - STAT3 Transcription Factor KW - Stat3 protein, mouse KW - Transcription Factor RelA KW - Peroxidase KW - EC 1.11.1.7 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Nos2 protein, mouse KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cybb protein, mouse KW - EC 1.6.3.1 KW - NADPH Oxidase KW - neutrophil cytosolic factor 1 KW - Index Medicus KW - Animals KW - NADPH Oxidase -- biosynthesis KW - Transcription Factor RelA -- metabolism KW - Neurons -- drug effects KW - Mice KW - Peroxidase -- biosynthesis KW - Cell Death -- drug effects KW - Nitric Oxide Synthase Type II -- biosynthesis KW - Pyrazoles -- pharmacology KW - Microglia -- physiology KW - Membrane Glycoproteins -- biosynthesis KW - Oxidative Stress -- drug effects KW - STAT3 Transcription Factor -- metabolism KW - Microglia -- drug effects KW - Male KW - Encephalitis -- physiopathology KW - Cyclooxygenase 1 -- deficiency KW - Encephalitis -- chemically induced KW - Cyclooxygenase Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69165835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Genetic+deletion+or+pharmacological+inhibition+of+cyclooxygenase-1+attenuate+lipopolysaccharide-induced+inflammatory+response+and+brain+injury.&rft.au=Choi%2C+Sang-Ho%3BLangenbach%2C+Robert%3BBosetti%2C+Francesca&rft.aulast=Choi&rft.aufirst=Sang-Ho&rft.date=2008-05-01&rft.volume=22&rft.issue=5&rft.spage=1491&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-28 N1 - Date created - 2008-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurology. 1995 Jan;45(1):51-5 [7824134] J Neurochem. 2007 Aug;102(3):577-86 [17403135] Cell. 1995 Nov 3;83(3):483-92 [8521478] J Neuropathol Exp Neurol. 1999 Nov;58(11):1135-46 [10560656] Nat Med. 1999 Dec;5(12):1403-9 [10581083] J Clin Invest. 2000 Feb;105(4):497-504 [10683379] Brain Res. 2000 Aug 25;874(2):123-30 [10960596] J Neuroimmunol. 2000 Nov 1;111(1-2):122-30 [11063829] Acta Neuropathol. 2001 Jan;101(1):2-8 [11194936] N Engl J Med. 2001 Nov 22;345(21):1515-21 [11794217] J Neurosurg. 2002 May;96(5):892-9 [12005397] Brain Res. 2002 Oct 4;951(2):218-26 [12270500] J Neurochem. 2002 Oct;83(2):463-70 [12423256] Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:535-56 [12432942] Ann Med. 2002;34(7-8):491-500 [12553488] Nat Rev Neurosci. 2003 Feb;4(2):103-12 [12563281] JAMA. 2003 Jun 4;289(21):2819-26 [12783912] J Neurochem. 2003 Aug;86(3):545-55 [12859668] Curr Drug Targets. 2003 Aug;4(6):461-8 [12866660] FASEB J. 2003 Oct;17(13):1922-4 [12923064] Neuroreport. 2003 Nov 14;14(16):2099-103 [14600505] J Immunol. 2003 Dec 1;171(11):6072-9 [14634121] J Biol Chem. 2004 Jan 9;279(2):1415-21 [14578353] J Neurochem. 2003 Dec;87(6):1518-26 [14713307] Neurology. 2004 Jan 13;62(1):66-71 [14718699] Anal Biochem. 1985 Jul;148(1):59-69 [2994521] Neurosci Lett. 1987 Aug 18;79(1-2):195-200 [3670729] Neurology. 1993 Aug;43(8):1609-11 [8351023] Biochim Biophys Acta. 1994 Nov 16;1209(1):130-9 [7947975] Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12013-7 [7991575] Neurology. 1996 Aug;47(2):425-32 [8757015] Brain Res. 1997 Mar 14;751(1):37-46 [9098566] Prostaglandins. 1997 Sep;54(3):601-24 [9373877] J Neuroimmunol. 1998 May 1;85(1):1-10 [9626992] Blood. 1999 Mar 1;93(5):1464-76 [10029572] Neurology. 1999 Jul 13;53(1):197-201 [10408559] Biochem Pharmacol. 1999 Oct 15;58(8):1237-46 [10487525] J Neurosci. 2005 Apr 20;25(16):4082-90 [15843610] Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):267-72 [15850932] J Neurochem. 2005 Jun;93(6):1561-7 [15935072] Neuropsychopharmacology. 2005 Jun;30(6):1204-15 [15742005] J Neurochem. 2005 Sep;94(6):1546-58 [16000148] Glia. 2006 Mar;53(4):382-91 [16288481] Brain Res. 2006 Jun 20;1095(1):85-95 [16697357] J Neurochem. 2006 Jun;97(6):1634-58 [16805774] J Neurochem. 2006 Aug;98(3):801-11 [16787416] Brain Res Rev. 2006 Sep;52(2):201-43 [16647138] Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1316-26 [16809483] Biochem Soc Trans. 2006 Dec;34(Pt 6):1267-70 [17073799] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Ann N Y Acad Sci. 2006 Nov;1088:219-29 [17192568] Brain Res Bull. 2007 Jun 15;73(1-3):108-13 [17499644] Neurobiol Aging. 1995 Jul-Aug;16(4):523-30 [8544901] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda. AN - 69164068; 18369368 AB - The simple deletion of nucleotides is common in many organisms. It can be advantageous when it activates genes beneficial to microbial survival in adverse environments, and deleterious when it mutates genes relevant to survival, cancer or degenerative diseases. The classical idea is that simple deletions arise by strand slippage. A prime opportunity for slippage occurs during DNA synthesis, but it remains unclear how slippage is controlled during a polymerization cycle. Here, we report crystal structures and molecular dynamics simulations of mutant derivatives of DNA polymerase lambda bound to a primer-template during strand slippage. Relative to the primer strand, the template strand is in multiple conformations, indicating intermediates on the pathway to deletion mutagenesis. Consistent with these intermediates, the mutant polymerases generate single-base deletions at high rates. The results indicate that dNTP-induced template strand repositioning during conformational rearrangements in the catalytic cycle is crucial to controlling the rate of strand slippage. JF - EMBO reports AU - Bebenek, Katarzyna AU - Garcia-Diaz, Miguel AU - Foley, Meredith C AU - Pedersen, Lars C AU - Schlick, Tamar AU - Kunkel, Thomas A AD - Laboratory of Structural Biology and Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 459 EP - 464 VL - 9 IS - 5 SN - 1469-221X, 1469-221X KW - DNA KW - 9007-49-2 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA polymerase beta2 KW - Lysine KW - K3Z4F929H6 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Computer Simulation KW - Alanine -- metabolism KW - Humans KW - Models, Chemical KW - Crystallography, X-Ray KW - Templates, Genetic KW - Nucleic Acid Conformation KW - Hydrogen Bonding KW - Lysine -- metabolism KW - Amino Acid Substitution KW - Gene Deletion KW - Catalysis KW - Binding Sites KW - DNA Repair KW - DNA Polymerase beta -- genetics KW - DNA Polymerase beta -- chemistry KW - DNA -- chemistry KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69164068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+reports&rft.atitle=Substrate-induced+DNA+strand+misalignment+during+catalytic+cycling+by+DNA+polymerase+lambda.&rft.au=Bebenek%2C+Katarzyna%3BGarcia-Diaz%2C+Miguel%3BFoley%2C+Meredith+C%3BPedersen%2C+Lars+C%3BSchlick%2C+Tamar%3BKunkel%2C+Thomas+A&rft.aulast=Bebenek&rft.aufirst=Katarzyna&rft.date=2008-05-01&rft.volume=9&rft.issue=5&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=EMBO+reports&rft.issn=1469221X&rft_id=info:doi/10.1038%2Fembor.2008.33 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-03 N1 - Date created - 2008-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Sep 8;275(36):28033-8 [10851238] DNA Repair (Amst). 2007 Dec 1;6(12):1709-25 [17631059] J Biomol Struct Dyn. 2002 Feb;19(4):571-84 [11843619] J Biol Chem. 2002 Aug 2;277(31):28157-66 [12023283] Proteins. 2003 Feb 15;50(3):437-50 [12557186] J Clin Oncol. 2003 Mar 15;21(6):1174-9 [12637487] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3895-900 [12649320] Cold Spring Harb Symp Quant Biol. 2000;65:81-91 [12760023] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] J Biol Chem. 2004 Apr 23;279(17):16895-8 [14988392] J Biol Chem. 2004 Oct 29;279(44):45360-8 [15339923] Cold Spring Harb Symp Quant Biol. 1966;31:77-84 [5237214] J Biol Chem. 1986 Oct 15;261(29):13581-7 [3759982] J Biol Chem. 1988 Oct 15;263(29):14784-9 [3049589] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] J Biol Chem. 1997 Aug 8;272(32):20205-12 [9242698] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] J Mol Biol. 1999 Jun 18;289(4):835-50 [10369765] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Nat Struct Mol Biol. 2005 Jan;12(1):97-8 [15608652] Nat Rev Genet. 2005 Oct;6(10):729-42 [16205713] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] DNA Repair (Amst). 2005 Dec 8;4(12):1358-67 [16213194] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] Biophys J. 2006 Nov 1;91(9):3182-95 [16920835] Annu Rev Genet. 2006;40:307-33 [17094739] Cell. 2001 Oct 5;107(1):91-102 [11595188] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/embor.2008.33 ER - TY - JOUR T1 - Cardiac toxicity and efficacy of trastuzumab combined with pertuzumab in patients with [corrected] human epidermal growth factor receptor 2-positive metastatic breast cancer. AN - 69161609; 18451236 AB - To evaluate safety and efficacy of trastuzumab with pertuzumab in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer who had progressive disease on trastuzumab-based therapy. Patients with measurable HER2(+) metastatic breast cancer, or = 55% received 8 or 6 mg/kg trastuzumab and 840 mg pertuzumab i.v. followed by 6 mg/kg trastuzumab and 420 mg pertuzumab every 3 weeks. Cardiac evaluation and tumor response were assessed every 3 and 6 weeks, respectively. Eleven patients received 64 cycles of trastuzumab plus pertuzumab. A total of 92 echocardiograms and 8 cardiac magnetic resonance imaging studies were done. With the lower limit of normal LVEF 55%, left ventricular systolic dysfunction was observed in six patients, three grade 1, two grade 2, and one grade 3 according to the National Cancer Institute Common Terminology Criteria for Adverse Events. The objective response rate was 18%. Two patients had partial responses, three had stable disease, and six had progressive disease. The median time to progression was 6 weeks. In baseline tumors from formalin-fixed paraffin-embedded primary and/or metastatic tumor biopsies, pHER2-Y1248 trended toward an increase in patients with partial response compared with those with stable disease/progressive disease (P = 0.095). Trastuzumab plus pertuzumab may have clinical benefit in selected patients who have previously been treated with trastuzumab. Cardiac toxicity, although asymptomatic in most cases, was associated with this treatment. Further evaluation of efficacy of this combination is required to define the overall risks and benefits. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Portera, Chia C AU - Walshe, Janice M AU - Rosing, Douglas R AU - Denduluri, Neelima AU - Berman, Arlene W AU - Vatas, Ujala AU - Velarde, Margarita AU - Chow, Catherine K AU - Steinberg, Seth M AU - Nguyen, Diana AU - Yang, Sherry X AU - Swain, Sandra M AD - Medical Oncology Branch, National Cancer Institute, Bethesda, MD, USA. Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 2710 EP - 2716 VL - 14 IS - 9 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - pertuzumab KW - K16AIQ8CTM KW - Trastuzumab KW - P188ANX8CK KW - Index Medicus KW - Receptor, ErbB-2 -- metabolism KW - Humans KW - Echocardiography KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Breast Neoplasms -- drug therapy KW - Heart -- drug effects KW - Breast Neoplasms -- metabolism KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Ventricular Dysfunction, Left -- chemically induced KW - Antibodies, Monoclonal -- administration & dosage KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69161609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Cardiac+toxicity+and+efficacy+of+trastuzumab+combined+with+pertuzumab+in+patients+with+%5Bcorrected%5D+human+epidermal+growth+factor+receptor+2-positive+metastatic+breast+cancer.&rft.au=Portera%2C+Chia+C%3BWalshe%2C+Janice+M%3BRosing%2C+Douglas+R%3BDenduluri%2C+Neelima%3BBerman%2C+Arlene+W%3BVatas%2C+Ujala%3BVelarde%2C+Margarita%3BChow%2C+Catherine+K%3BSteinberg%2C+Seth+M%3BNguyen%2C+Diana%3BYang%2C+Sherry+X%3BSwain%2C+Sandra+M&rft.aulast=Portera&rft.aufirst=Chia&rft.date=2008-05-01&rft.volume=14&rft.issue=9&rft.spage=2710&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-4636 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-18 N1 - Date created - 2008-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Clin Cancer Res. 2008 Jun 1;14(11):3641 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-4636 ER - TY - JOUR T1 - Cardiovascular assessment of fetal mice by in utero echocardiography. AN - 69150344; 18328616 AB - To establish a developmental profile of fetal mouse cardiovascular parameters, we analyzed a large body of ultrasound measurements obtained by in utero echocardiography of C57BL/6J fetal mice from embryonic day 12.5 to 19.5 (term). Measurements were obtained using two-dimensional (2D), spectral Doppler and M-mode imaging with standard clinical cardiac ultrasound imaging planes. As these studies were conducted as part of a large scale mouse mutagenesis screen, stringent filtering criteria were used to eliminate potentially abnormal fetuses. Our analysis showed heart rate increased from 190 to 245 beats per minute as the mouse fetus grew from 8 mm at embryonic day 12.5 to 18.7 mm at term. This was accompanied by increases in peak outflow velocity, E-wave, E/A ratio and ventricular dimensions. In contrast, the A-wave, myocardial performance index and isovolemic contraction time decreased gradually. Systolic function remained remarkably stable at 80% ejection fraction. Analysis of intra- and interobserver variabilities showed these parameters were reproducible, with most comparing favorably to clinical ultrasound measurements in human fetuses. A comprehensive database was generated comprising 23 echocardiographic parameters delineating fetal mouse cardiovascular function from embryonic day 12.5 to term. This database can serve as a standard for evaluating cardiovascular pathophysiology in genetically altered and mutant mouse models. JF - Ultrasound in medicine & biology AU - Yu, Qing AU - Leatherbury, Linda AU - Tian, Xin AU - Lo, C W AD - Laboratory of Developmental Biology, National Heart Lung and Blood Institute, Bethesda, Maryland, USA. Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 741 EP - 752 VL - 34 IS - 5 SN - 0301-5629, 0301-5629 KW - Index Medicus KW - Models, Animal KW - Animals KW - Signal Processing, Computer-Assisted KW - Heart Rate, Fetal KW - Gestational Age KW - Mice, Inbred C57BL KW - Echocardiography, Doppler KW - Mice KW - Systole KW - Regional Blood Flow KW - Female KW - Stroke Volume KW - Pregnancy KW - Fetal Heart -- diagnostic imaging KW - Fetal Heart -- embryology KW - Ultrasonography, Prenatal -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69150344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+medicine+%26+biology&rft.atitle=Cardiovascular+assessment+of+fetal+mice+by+in+utero+echocardiography.&rft.au=Yu%2C+Qing%3BLeatherbury%2C+Linda%3BTian%2C+Xin%3BLo%2C+C+W&rft.aulast=Yu&rft.aufirst=Qing&rft.date=2008-05-01&rft.volume=34&rft.issue=5&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+medicine+%26+biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2007.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2007.11.001 ER - TY - JOUR T1 - RNase A ribonucleases and host defense: an evolving story. AN - 69147474; 18211964 AB - RNase A (bovine pancreatic RNase) is the founding member an extensive family of divergent proteins that share specific elements of sequence homology, a unique disulfide-bonded tertiary structure, and the ability to hydrolyze polymeric RNA. Among the more intriguing and perhaps counterintuitive findings, at the current state of the art, the connection between RNase activity and characterized host defense functions is quite weak; whether this is a scientific reality or more a reflection of what has been chosen for study remains to be determined. Several of the RNase A family RNases are highly cationic and have cytotoxic and bactericidal properties that are clearly (eosinophil cationic protein, leukocyte RNase A-2) or are probably (RNase 7) unrelated to their enzymatic activity. Interestingly, peptides derived from the leukocyte RNase A-2 sequence are nearly as bactericidal as the entire protein, suggesting that among other functions, the RNase A superfamily may be serving as a source of gene scaffolds for the generation of novel cytotoxic peptides. Other RNase A ribonucleases are somewhat less cationic (mouse angiogenin 4, zebrafish RNases) and have moderate bactericidal activities that have not yet been explored mechanistically. Additional host defense functions characterized specifically for the RNase eosinophil-derived neurotoxin include reducing infectivity of RNA viruses for target cells in culture, which does require RNase activity, chemoattraction of immature human dendritic cells via a G-protein-coupled receptor-dependent mechanism, and activation of TLR2. The properties of individual RNase A ribonucleases, recent experimental findings, and important questions for the near and distant future will be reviewed. JF - Journal of leukocyte biology AU - Rosenberg, Helene F AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. hrosenberg@niaid.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1079 EP - 1087 VL - 83 IS - 5 SN - 0741-5400, 0741-5400 KW - Ribonucleases KW - EC 3.1.- KW - Eosinophil Cationic Protein KW - EC 3.1.27.- KW - Ribonuclease 7 KW - angiogenin KW - Ribonuclease, Pancreatic KW - EC 3.1.27.5 KW - Index Medicus KW - Leukocytes -- enzymology KW - Animals KW - Eosinophil Cationic Protein -- metabolism KW - Chickens KW - Cattle KW - Mammals KW - Rana catesbeiana KW - Eosinophils -- enzymology KW - Pancreas -- enzymology KW - Ribonucleases -- metabolism KW - Zebrafish KW - Ribonuclease, Pancreatic -- classification KW - Ribonuclease, Pancreatic -- metabolism KW - Ribonuclease, Pancreatic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69147474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=RNase+A+ribonucleases+and+host+defense%3A+an+evolving+story.&rft.au=Rosenberg%2C+Helene+F&rft.aulast=Rosenberg&rft.aufirst=Helene&rft.date=2008-05-01&rft.volume=83&rft.issue=5&rft.spage=1079&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.1107725 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-13 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Microbiol. 2006 Dec;53(6):477-8 [17106799] Mol Divers. 2006 Nov;10(4):585-97 [16969722] J Immunol. 1989 Aug 1;143(3):952-5 [2745977] J Exp Med. 1989 Jul 1;170(1):163-76 [2473157] Gene. 1989 Nov 15;83(1):161-7 [2591744] J Biochem. 1989 Nov;106(5):729-35 [2613682] J Immunol. 1990 Apr 15;144(8):3166-73 [2324497] J Biol Chem. 1991 Jan 5;266(1):245-51 [1985896] Biochem Biophys Res Commun. 1992 May 29;185(1):231-9 [1599460] J Biol Chem. 1995 Apr 7;270(14):7876-81 [7713881] Nat Genet. 1995 Jun;10(2):219-23 [7663519] J Biol Chem. 1995 Sep 15;270(37):21539-44 [7665566] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5 [8901588] Biochemistry. 2007 Jan 23;46(3):720-33 [17223693] Clin Exp Allergy. 2007 Feb;37(2):208-18 [17250693] J Mol Evol. 2001 Jul;53(1):31-8 [11683320] J Leukoc Biol. 2001 Nov;70(5):691-8 [11698487] Nucleic Acids Res. 2002 Mar 1;30(5):1169-75 [11861908] Mol Biol Evol. 2002 Apr;19(4):438-45 [11919285] Am J Respir Cell Mol Biol. 2002 Dec;27(6):678-87 [12444027] J Biol Chem. 2002 Nov 29;277(48):46779-84 [12244054] Nucleic Acids Res. 2003 Jan 15;31(2):602-7 [12527768] AIDS. 2003 Mar 7;17(4):481-6 [12598767] Nat Immunol. 2003 Mar;4(3):269-73 [12548285] Biochemistry. 2003 Jun 10;42(22):6636-44 [12779318] Biochim Biophys Acta. 2003 Jul 14;1638(2):164-72 [12853122] Blood. 2003 Nov 1;102(9):3396-403 [12855582] Mol Endocrinol. 2003 Nov;17(11):2138-51 [12920233] J Allergy Clin Immunol. 2004 Jan;113(1):30-7 [14713904] Biol Reprod. 2004 Feb;70(2):319-28 [14561640] Med Hypotheses. 2004;62(3):367-74 [14975505] Proc Natl Acad Sci U S A. 1981 Aug;78(8):5165-9 [6946462] J Immunol. 1983 Dec;131(6):2977-82 [6644025] Am J Trop Med Hyg. 1985 Jul;34(4):735-45 [4025686] Biochemistry. 1985 Sep 24;24(20):5494-9 [2866795] Blood. 1986 Feb;67(2):498-503 [3942834] Proc Natl Acad Sci U S A. 1986 May;83(10):3146-50 [3458170] Nature. 1986 Jun 5-11;321(6070):613-6 [2423882] J Immunol. 1986 Nov 1;137(9):2913-7 [3760576] J Parasitol. 1987 Jun;73(3):523-9 [3598802] Am J Trop Med Hyg. 1988 Mar;38(2):327-34 [2451444] J Immunol. 1989 Jun 15;142(12):4428-34 [2656865] Proc Natl Acad Sci U S A. 1989 Jun;86(12):4460-4 [2734298] J Infect Dis. 1998 Jun;177(6):1458-64 [9607820] Cell Mol Life Sci. 1998 Aug;54(8):763-5 [9760984] Cell Mol Life Sci. 1998 Aug;54(8):825-32 [9760991] Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2678-81 [10077570] J Biol Chem. 1954 Dec;211(2):941-50 [13221599] Fed Proc. 1956 Jul;15(2):840-8 [13356878] J Biol Chem. 1959 May;234(5):1112-7 [13654330] J Immunol. 2004 Nov 15;173(10):6134-42 [15528350] Pharmacol Ther. 2005 Jan;105(1):1-6 [15626452] Genomics. 2005 Feb;85(2):208-20 [15676279] Clin Exp Allergy. 2005 Aug;35(8):986-94 [16120079] J Immunol. 2005 Oct 1;175(7):4735-44 [16177121] Cancer Invest. 2005;23(7):643-50 [16305992] Expert Opin Biol Ther. 2006 Apr;6(4):391-9 [16548765] Annu Rev Immunol. 2006;24:147-74 [16551246] J Biol Chem. 2006 Sep 1;281(35):25622-34 [16803891] Antimicrob Agents Chemother. 2006 Sep;50(9):3194-6 [16940129] J Biol Chem. 2006 Sep 15;281(37):27454-60 [16861230] J Thromb Haemost. 2006 Sep;4(9):1864-74 [16961595] J Biol Chem. 2007 Feb 16;282(7):4626-33 [17150966] Mol Biosyst. 2007 May;3(5):317-35 [17460791] Mol Biol Evol. 2007 May;24(5):1259-68 [17347156] J Allergy Clin Immunol. 2007 Jun;119(6):1313-20 [17481717] Int J Oncol. 2007 Sep;31(3):663-9 [17671695] Mol Biol Evol. 2007 Aug;24(8):1596-9 [17488738] Blood. 2007 Sep 1;110(5):1578-86 [17495130] Adv Exp Med Biol. 2007;601:185-94 [17713005] Int J Parasitol. 2007 Oct;37(12):1359-66 [17507019] Gene. 2007 Dec 30;406(1-2):8-12 [17616268] J Exp Med. 2008 Jan 21;205(1):79-90 [18195069] Immunol Res. 1999;20(3):261-74 [10741866] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4701-6 [10758160] Genetics. 2000 Dec;156(4):1949-58 [11102386] Int Arch Allergy Immunol. 2001 Jul;125(3):241-9 [11490157] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1189/jlb.1107725 ER - TY - JOUR T1 - Agreement between diary records of time spent outdoors and personal ultraviolet radiation dose measurements. AN - 69139968; 18435619 AB - Little is known about the validity of self-recorded sun exposure and time spent outdoors for epidemiological research. The aims of the current study were to assess how well participants' self-recorded time outdoors compared to objective measurements of personal UVR doses. We enrolled 124 volunteers aged 40 and above who were identified from targeted subgroups of US radiologic technologists. Each volunteer was instructed to wear a polysulfone (PS) dosimeter to measure UVR on their left shoulder and to complete a daily activity diary, listing all activities undertaken in each 30 min interval between 9:00 A.M. and 5:00 P.M. during a 7 day period. In a linear regression model, self-recorded daily time spent outdoors was associated with an increase of 8.2% (95% CI: 7.3-9.2%) in the personal UVR exposure with every hour spent outdoors. The amount of self-recorded total daily time spent outdoors was better correlated with the personal daily UVR dose for activities conducted near noon time compared to activities conducted in the morning or late afternoon, and for activities often performed in the sun (e.g. gardening or recreation activities) compared to other outdoor activities (e.g. driving) in which the participant is usually shaded from the sun. Our results demonstrated a significant correlation between diary records of time spent outdoors with objective personal UVR dose measurements. JF - Photochemistry and photobiology AU - Chodick, Gabriel AU - Kleinerman, Ruth A AU - Linet, Martha S AU - Fears, Tom AU - Kwok, Richard K AU - Kimlin, Michael G AU - Alexander, Bruce H AU - Freedman, Daryl M AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, USA. hodik_g@mac.org.il PY - 2008 SP - 713 EP - 718 VL - 84 IS - 3 SN - 0031-8655, 0031-8655 KW - Index Medicus KW - Medical Records KW - Humans KW - Adult KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Film Dosimetry KW - Radiation Dosage KW - Ultraviolet Rays KW - Environmental Exposure -- statistics & numerical data KW - Surveys and Questionnaires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69139968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Agreement+between+diary+records+of+time+spent+outdoors+and+personal+ultraviolet+radiation+dose+measurements.&rft.au=Chodick%2C+Gabriel%3BKleinerman%2C+Ruth+A%3BLinet%2C+Martha+S%3BFears%2C+Tom%3BKwok%2C+Richard+K%3BKimlin%2C+Michael+G%3BAlexander%2C+Bruce+H%3BFreedman%2C+Daryl+M&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2008-05-01&rft.volume=84&rft.issue=3&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/10.1111%2Fj.1751-1097.2007.00236.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-04-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Stat Med. 2004 May 30;23(10):1603-19 [15122740] Arch Dermatol. 2004 Feb;140(2):197-203 [14967793] Photochem Photobiol. 1994 Sep;60(3):288-94 [7972383] Br J Dermatol. 1996 Jun;134(6):1030-4 [8763419] Melanoma Res. 1996 Jun;6(3):231-9 [8819126] Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):11-4 [8990152] Photochem Photobiol. 1998 Jul;68(1):78-83 [9679453] J Invest Dermatol. 2004 Dec;123(6):1147-50 [15610527] J Natl Cancer Inst. 2005 Feb 2;97(3):195-9 [15687362] J Natl Cancer Inst. 2005 Feb 2;97(3):199-209 [15687363] Photochem Photobiol. 2005 Jul-Aug;81(4):736-49 [15819599] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2427-32 [16214927] Photodermatol Photoimmunol Photomed. 2006 Apr;22(2):93-9 [16606414] Eur J Cancer. 2006 Sep;42(14):2222-32 [16904314] Photochem Photobiol. 2000 Jan;71(1):60-4 [10649890] J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):231-52 [11477521] J Photochem Photobiol B. 2001 Oct;63(1-3):8-18 [11684447] Photodermatol Photoimmunol Photomed. 2001 Dec;17(6):249-55 [11722749] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Photodermatol Photoimmunol Photomed. 2003 Aug;19(4):175-81 [12925188] Occup Environ Med. 2003 Nov;60(11):815-20 [14573711] Cancer. 1992 Jan 15;69(2):586-98 [1728391] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1751-1097.2007.00236.x ER - TY - JOUR T1 - A high-throughput system for segmenting nuclei using multiscale techniques. AN - 69132833; 18338778 AB - Automatic segmentation of cell nuclei is critical in several high-throughput cytometry applications whereas manual segmentation is laborious and irreproducible. One such emerging application is measuring the spatial organization (radial and relative distances) of fluorescence in situ hybridization (FISH) DNA sequences, where recent investigations strongly suggest a correlation between nonrandom arrangement of genes to carcinogenesis. Current automatic segmentation methods have varying performance in the presence of nonuniform illumination and clustering, and boundary accuracy is seldom assessed, which makes them suboptimal for this application. The authors propose a modular and model-based algorithm for extracting individual nuclei. It uses multiscale edge reconstruction for contrast stretching and edge enhancement as well as a multiscale entropy-based thresholding for handling nonuniform intensity variations. Nuclei are initially oversegmented and then merged based on area followed by automatic multistage classification into single nuclei and clustered nuclei. Estimation of input parameters and training of the classifiers is automatic. The algorithm was tested on 4,181 lymphoblast nuclei with varying degree of background nonuniformity and clustering. It extracted 3,515 individual nuclei and identified single nuclei and individual nuclei in clusters with 99.8 +/- 0.3% and 95.5 +/- 5.1% accuracy, respectively. Segmented boundaries of the individual nuclei were accurate when compared with manual segmentation with an average RMS deviation of 0.26 microm (approximately 2 pixels). The proposed segmentation method is efficient, robust, and accurate for segmenting individual nuclei from fluorescence images containing clustered and isolated nuclei. The algorithm allows complete automation and facilitates reproducible and unbiased spatial analysis of DNA sequences. Published 2008 Wiley-Liss, Inc. JF - Cytometry. Part A : the journal of the International Society for Analytical Cytology AU - Gudla, Prabhakar R AU - Nandy, K AU - Collins, J AU - Meaburn, K J AU - Misteli, T AU - Lockett, S J AD - Image Analysis Laboratory, Advanced Technology Program, SAIC-Frederick, NCI-Frederick, Frederick, Maryland 21702, USA. reddyg@ncifcrf.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 451 EP - 466 VL - 73 IS - 5 KW - Index Medicus KW - Humans KW - Cell Compartmentation KW - Databases, Factual KW - Algorithms KW - Lymphocytes -- metabolism KW - Lymphocytes -- ultrastructure KW - Sequence Analysis, DNA KW - Image Processing, Computer-Assisted KW - Cell Nucleus -- classification KW - Image Cytometry -- statistics & numerical data KW - Cell Nucleus -- ultrastructure KW - Cell Nucleus -- metabolism KW - Image Cytometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69132833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry.+Part+A+%3A+the+journal+of+the+International+Society+for+Analytical+Cytology&rft.atitle=A+high-throughput+system+for+segmenting+nuclei+using+multiscale+techniques.&rft.au=Gudla%2C+Prabhakar+R%3BNandy%2C+K%3BCollins%2C+J%3BMeaburn%2C+K+J%3BMisteli%2C+T%3BLockett%2C+S+J&rft.aulast=Gudla&rft.aufirst=Prabhakar&rft.date=2008-05-01&rft.volume=73&rft.issue=5&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Cytometry.+Part+A+%3A+the+journal+of+the+International+Society+for+Analytical+Cytology&rft.issn=1552-4930&rft_id=info:doi/10.1002%2Fcyto.a.20550 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-04 N1 - Date created - 2008-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cyto.a.20550 ER - TY - JOUR T1 - The heavy metal cadmium induces valosin-containing protein (VCP)-mediated aggresome formation. AN - 69129113; 18261755 AB - Cadmium (Cd2+) is a heavy metal ion known to have a long biological half-life in humans. Accumulating evidence shows that exposure to Cd2+ is associated with neurodegenerative diseases characterized by the retention of ubiquitinated and misfolded proteins in the lesions. Here, we report that Cd2+ directly induces the formation of protein inclusion bodies in cells. The protein inclusion body is an aggresome, a major organelle for collecting ubiquitinated or misfolded proteins. Our results show that aggresomes are enriched in the detergent-insoluble fraction of Cd2+-treated cell lysates. Proteomic analysis identified 145 proteins in the aggresome-enriched fractions. One of the proteins is the highly conserved valosin-containing protein (VCP), which has been shown to colocalize with aggresomes and bind ubiquitinated proteins through its N domain (#1-200). Our subsequent examination of VCP's role in the formation of aggresomes induced by Cd2+ indicates that the C-terminal tail (#780-806) of VCP interacts with histone deacetylase HDAC6, a mediator for aggresome formation, suggesting that VCP participates in transporting ubiquitinated proteins to aggresomes. This function of VCP is impaired by inhibition of the deacetylase activity of HDAC6 or by over-expression of VCP mutants that do not bind ubiquitinated proteins or HDAC6. Our results indicate that Cd2+ induces the formation of protein inclusion bodies by promoting the accumulation of ubiquitinated proteins in aggresomes through VCP and HDAC6. Our delineation of the role of VCP in regulating cell responses to ubiquitinated proteins has important implications for understanding Cd2+ toxicity and associated diseases. JF - Toxicology and applied pharmacology AU - Song, Changcheng AU - Xiao, Zhen AU - Nagashima, Kunio AU - Li, Chou-Chi H AU - Lockett, Stephen J AU - Dai, Ren-Ming AU - Cho, Edward H AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Colburn, Nancy H AU - Wang, Qing AU - Wang, Ji Ming AD - Laboratory of Cancer Prevention, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD 21702, USA. songc@ncifcrf.gov Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 351 EP - 363 VL - 228 IS - 3 SN - 0041-008X, 0041-008X KW - Cell Cycle Proteins KW - 0 KW - Ubiquitin KW - Cadmium KW - 00BH33GNGH KW - HDAC6 protein, human KW - EC 3.5.1.98 KW - Histone Deacetylases KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - CDC48 protein KW - Index Medicus KW - Mass Spectrometry KW - Cells, Cultured KW - Humans KW - Histone Deacetylases -- physiology KW - Protein Structure, Tertiary KW - Cell Cycle Proteins -- physiology KW - Cell Cycle Proteins -- chemistry KW - Ubiquitin -- metabolism KW - Adenosine Triphosphatases -- physiology KW - Inclusion Bodies -- metabolism KW - Protein Folding KW - Cadmium -- toxicity KW - Adenosine Triphosphatases -- chemistry KW - Inclusion Bodies -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69129113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=The+heavy+metal+cadmium+induces+valosin-containing+protein+%28VCP%29-mediated+aggresome+formation.&rft.au=Song%2C+Changcheng%3BXiao%2C+Zhen%3BNagashima%2C+Kunio%3BLi%2C+Chou-Chi+H%3BLockett%2C+Stephen+J%3BDai%2C+Ren-Ming%3BCho%2C+Edward+H%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BColburn%2C+Nancy+H%3BWang%2C+Qing%3BWang%2C+Ji+Ming&rft.aulast=Song&rft.aufirst=Changcheng&rft.date=2008-05-01&rft.volume=228&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.12.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-04-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2000 May 15;19(10):2181-92 [10811609] EMBO J. 1999 Dec 15;18(24):6934-49 [10601016] Int J Occup Environ Health. 2001 Apr-Jun;7(2):109-12 [11373040] Nat Cell Biol. 2001 Aug;3(8):740-4 [11483959] Mol Cell Biol. 2001 Dec;21(23):8035-44 [11689694] J Exp Bot. 2002 Jan;53(366):1-11 [11741035] Neurosci Lett. 2002 May 3;323(3):215-8 [11959423] Neurobiol Dis. 2002 Jul;10(2):109-18 [12127149] Cell Motil Cytoskeleton. 2002 Sep;53(1):26-38 [12211113] J Neurochem. 2002 Aug;82(4):819-27 [12358787] J Biol Chem. 2002 Dec 6;277(49):47870-7 [12364339] J Biol Chem. 2002 Dec 13;277(50):48976-83 [12351642] Cell. 2003 Dec 12;115(6):727-38 [14675537] Mol Cell. 2003 Dec;12(6):1349-51 [14690590] Histol Histopathol. 2004 Jan;19(1):69-76 [14702173] J Cell Biochem. 2004 Feb 1;91(2):384-97 [14743397] J Struct Biol. 2004 Apr-May;146(1-2):44-57 [15037236] Curr Biol. 2004 Mar 23;14(6):488-92 [15043813] Mol Cell Proteomics. 2004 Jun;3(6):596-607 [15004206] J Neurochem. 2004 Jul;90(1):19-28 [15198663] Mol Pharmacol. 2004 Oct;66(4):1022-8 [15258259] Environ Health Perspect. 1974 May;7:121-7 [4364645] J Natl Cancer Inst. 1976 Feb;56(2):245-63 [1255758] Proc Natl Acad Sci U S A. 1976 Jul;73(7):2424-8 [1065897] Arch Environ Health. 1976 Nov-Dec;31(6):292-302 [999342] Acta Neuropathol. 1978 Mar 15;41(3):185-90 [206091] J Biol Chem. 1981 Jun 10;256(11):5916-20 [6263895] EMBO J. 1990 Jun;9(6):1757-67 [2140770] J Am Geriatr Soc. 1990 Jun;38(6):633-9 [2358624] Isr J Med Sci. 1992 Aug-Sep;28(8-9):578-83 [1428813] Nature. 1993 Jan 28;361(6410):369-71 [8381213] Eur J Cell Biol. 1996 Nov;71(3):311-8 [8929570] Ital J Neurol Sci. 1997 Apr;18(2):87-92 [9239528] J Biol Chem. 1998 Feb 6;273(6):3562-73 [9452483] Clin Neurol Neurosurg. 1997 Dec;99(4):263-5 [9491302] J Cell Biol. 1998 Dec 28;143(7):1883-98 [9864362] Mol Biol Rep. 1999 Apr;26(1-2):65-9 [10363649] Appl Microbiol Biotechnol. 1999 Jun;51(6):730-50 [10422221] Electrophoresis. 1999 Aug;20(11):2149-59 [10493120] J Cell Biol. 1999 Sep 20;146(6):1239-54 [10491388] Biochim Biophys Acta. 2004 Nov 29;1695(1-3):189-207 [15571815] Biometals. 2004 Oct;17(5):485-9 [15688851] Methods Mol Med. 2005;108:381-93 [16028696] J Biol Chem. 2005 Dec 2;280(48):40282-92 [16192271] FEBS Lett. 2006 Jan 23;580(2):474-8 [16386250] Proteomics. 2006 Jan;6(2):449-55 [16317776] Trends Cell Biol. 2000 Dec;10(12):524-30 [11121744] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2007.12.026 ER - TY - JOUR T1 - Drinking water disinfection by-products and time to pregnancy. AN - 69111897; 18379423 AB - Laboratory evidence suggests tap water disinfection by-products (DBPs) could have an effect very early in pregnancy, typically before clinical detectability. Undetected early losses would be expected to increase the reported number of cycles to clinical pregnancy. We investigated the association between specific DBPs (trihalomethanes, haloacetic acids, brominated-trihalomethanes, brominated-haloacetic acids, total organic halides, and bromodichloromethane) and time to pregnancy among women who enrolled in a study of drinking water and reproductive outcomes. We quantified exposure to DBPs through concentrations in tap water, quantity ingested through drinking, quantity inhaled or absorbed while showering or bathing, and total integrated exposure. The effect of DBPs on time to pregnancy was estimated using a discrete time hazard model. Overall, we found no evidence of an increased time to pregnancy among women who were exposed to higher levels of DBPs. A modestly decreased time to pregnancy (ie, increased fecundability) was seen among those exposed to the highest level of ingested DBPs, but not for tap water concentration, the amount absorbed while showering or bathing, or the integrated exposure. Our findings extend those of a recently published study suggesting a lack of association between DBPs and pregnancy loss. JF - Epidemiology (Cambridge, Mass.) AU - MacLehose, Richard F AU - Savitz, David A AU - Herring, Amy H AU - Hartmann, Katherine E AU - Singer, Philip C AU - Weinberg, Howard S AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709-2233, USA. maclehoser@niehs.ni.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 451 EP - 458 VL - 19 IS - 3 SN - 1044-3983, 1044-3983 KW - Disinfectants KW - 0 KW - Hydrocarbons, Halogenated KW - Trihalomethanes KW - Water Pollutants, Chemical KW - Index Medicus KW - Humans KW - Environmental Exposure -- analysis KW - Trihalomethanes -- analysis KW - Prospective Studies KW - Risk Factors KW - Adult KW - Hydrocarbons, Halogenated -- analysis KW - Trihalomethanes -- adverse effects KW - Surveys and Questionnaires KW - Data Interpretation, Statistical KW - Environmental Exposure -- adverse effects KW - Hydrocarbons, Halogenated -- adverse effects KW - United States -- epidemiology KW - Time Factors KW - Female KW - Water Supply -- analysis KW - Disinfectants -- adverse effects KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- adverse effects KW - Water Purification -- methods KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69111897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Drinking+water+disinfection+by-products+and+time+to+pregnancy.&rft.au=MacLehose%2C+Richard+F%3BSavitz%2C+David+A%3BHerring%2C+Amy+H%3BHartmann%2C+Katherine+E%3BSinger%2C+Philip+C%3BWeinberg%2C+Howard+S&rft.aulast=MacLehose&rft.aufirst=Richard&rft.date=2008-05-01&rft.volume=19&rft.issue=3&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/10.1097%2FEDE.0b013e31816a23eb LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-31 N1 - Date created - 2008-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/EDE.0b013e31816a23eb ER - TY - JOUR T1 - P-glycoprotein--a clinical target in drug-refractory epilepsy? AN - 69104090; 18314494 AB - ATP-binding cassette transporters such as P-glycoprotein (Pgp), multidrug resistance-associated protein, and breast cancer resistance protein are known to transport a wide range of substrates and are highly expressed in the capillary endothelial cells that form part of the blood-brain barrier. It is noteworthy that P-glycoprotein has been shown to be up-regulated in animal models of refractory epilepsy, and adding a Pgp inhibitor to treatment regimens has been shown to reverse the drug-resistant phenotype. Limited data have suggested a role for Pgp in epilepsy in humans as well. However, few epilepsy drugs have been shown to be transported by Pgp, leading to controversy over whether Pgp actually plays a role in drug-resistant epilepsy. In this issue of Molecular Pharmacology, Bauer et al. (p. 1444) demonstrate that glutamate can cause localized up-regulation of Pgp via cyclooxygenase-2 (COX-2) and that this phenomenon can be prevented with COX-2 inhibitors. Localized rather than global up-regulation of Pgp may explain some of the difficulty investigators have had in proving a role for Pgp in epilepsy. The results add new support for future clinical trials targeting Pgp expression in drug-refractory epilepsy. JF - Molecular pharmacology AU - Robey, Robert W AU - Lazarowski, Alberto AU - Bates, Susan E AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. robeyr@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1343 EP - 1346 VL - 73 IS - 5 KW - P-Glycoprotein KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Glutamic Acid KW - 3KX376GY7L KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Index Medicus KW - Rats KW - Animals KW - Capillaries -- pathology KW - Capillaries -- enzymology KW - Capillaries -- drug effects KW - Up-Regulation -- genetics KW - Mice KW - Cyclooxygenase 2 -- metabolism KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Glutamic Acid -- pharmacology KW - Seizures -- chemically induced KW - P-Glycoprotein -- genetics KW - Seizures -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69104090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=P-glycoprotein--a+clinical+target+in+drug-refractory+epilepsy%3F&rft.au=Robey%2C+Robert+W%3BLazarowski%2C+Alberto%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2008-05-01&rft.volume=73&rft.issue=5&rft.spage=1343&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/10.1124%2Fmol.108.046680 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-06 N1 - Date created - 2008-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Mol Pharmacol. 2008 May;73(5):1444-53 [18094072] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/mol.108.046680 ER - TY - JOUR T1 - ENVIRONMENTAL HEALTH RESEARCH ON HAZARDS IN THE HOME AND THE DUTY TO WARN AN - 57278901; 200916625 AB - When environmental health researchers study hazards in the home, they often discover information that may be relevant to protecting the health and safety of the research subjects and occupants. This article describes the ethical and legal basis for a duty to warn research subjects and occupants about hazards in the home and explores the extent of this duty. Investigators should inform research subjects and occupants about the results of tests conducted as part of the research protocol only if the information is likely to be accurate, reliable, and medically useful. Investigators should warn subjects and occupants about hazards they happen to discover while they are in the home, if a reasonable person would warn the subjects and occupants about those hazards. Investigators should not report illegal hazards discovered in the home to the authorities, unless those hazards constitute abuse or neglect of children or mentally disabled people living in the home. When investigators decide to warn research subjects and occupants about hazards in the home, they should take some steps to help them make effective use of this information, such as providing additional counselling or making a referral for remediation or medical treatment. Investigators should discuss these issues with research subjects during the informed consent process. Adapted from the source document. JF - Bioethics AU - Resnik, David B AU - Zeldin, Darryl C AD - NIH - NIEHS, United States resnikd@niehs.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 209 EP - 217 PB - Blackwell, Oxford UK VL - 22 IS - 4 SN - 0269-9702, 0269-9702 KW - Mandatory reporting KW - Hazards KW - Informed consent KW - Medical research KW - Environmental health KW - Disabled children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57278901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioethics&rft.atitle=ENVIRONMENTAL+HEALTH+RESEARCH+ON+HAZARDS+IN+THE+HOME+AND+THE+DUTY+TO+WARN&rft.au=Resnik%2C+David+B%3BZeldin%2C+Darryl+C&rft.aulast=Resnik&rft.aufirst=David&rft.date=2008-05-01&rft.volume=22&rft.issue=4&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Bioethics&rft.issn=02699702&rft_id=info:doi/10.1111%2Fj.1467-8519.2008.00638.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BIETEE N1 - SubjectsTermNotLitGenreText - Hazards; Mandatory reporting; Environmental health; Medical research; Informed consent; Disabled children DO - http://dx.doi.org/10.1111/j.1467-8519.2008.00638.x ER - TY - JOUR T1 - Short communication: Longitudinal ECG changes in cocaine users during extended abstinence AN - 57258961; 200819851 AB - Background: Cocaine lengthens electrocardiographic QTc, QRS and PR intervals through blockade of sodium and potassium channels, but changes during withdrawal have not been well studied. Methods: We recorded weekly electrocardiograms (ECGs) from 25 physically healthy cocaine users (84.0% men, mean [S.D.] age 34.7 [4.1] years, 9.0 [5.2] years of cocaine use, 9.4 [3.5] days of use in the 2 weeks prior to admission) over 3 months of monitored abstinence on a closed ward. Subjects had minimal current use of other drugs. Baseline ECGs were recorded 20.5 h [16.6] after last cocaine use. Results: Baseline QTc interval correlated positively with total amount of cocaine used and amount used per day in the 2 weeks prior to ward admission. There was a significant 10.5 ms [12.9] shortening of QTc interval during the first week of withdrawal, with no further significant changes thereafter. There were no significant changes in PR or QRS intervals. Conclusions: These findings suggest that cocaine-associated QTc prolongation returns toward normal during the first week of cocaine abstinence. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Levin, Kenneth H AU - Copersino, Marc L AU - Epstein, David AU - Boyd, Susan J AU - Gorelick, David A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 160 EP - 163 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 95 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Cocaine KW - ECG KW - Withdrawal KW - QTc KW - Longitudinal KW - Abstinence KW - Drug dependency units KW - Electrocardiography KW - QT dispersion KW - Withdrawal symptoms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57258961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Short+communication%3A+Longitudinal+ECG+changes+in+cocaine+users+during+extended+abstinence&rft.au=Levin%2C+Kenneth+H%3BCopersino%2C+Marc+L%3BEpstein%2C+David%3BBoyd%2C+Susan+J%3BGorelick%2C+David+A&rft.aulast=Levin&rft.aufirst=Kenneth&rft.date=2008-05-01&rft.volume=95&rft.issue=1-2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.12.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Cocaine; Withdrawal symptoms; Abstinence; Electrocardiography; QT dispersion; Drug dependency units DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.12.001 ER - TY - JOUR T1 - A prospective study of risk drinking: At risk for what? AN - 57254869; 200819159 AB - Data from two waves of a nationally representative U.S. population sample were used to link frequency of risk drinking in the year preceding the Wave 1 interview with the incidence or occurrence of various adverse outcomes in the approximately 3-year-period between the two interviews (n = 22,122 Wave 1 drinkers who were reinterviewed at Wave 2). Risk drinking was defined as consuming the equivalent of 5+ standard drinks in a day for men and the equivalent of 4+ standard drinks in a day for women. Controls included sociodemographic and health characteristics, mean quantity of drinks consumed on risk drinking days and average volume of intake on non-risk drinking days. The odds of nonhierarchical alcohol abuse and dependence, initiation of smoking and incidence of nicotine dependence were increased at all frequencies of risk drinking and showed a fairly continuous increase in magnitude with increasing frequency, reaching OR of 3.037.23 for daily/near daily risk drinking. The incidence of liver disease was strongly increased among weekly or more frequent risk drinkers (OR = 2.784.76). The odds of social harm and drug use were increased among daily/near daily risk drinkers (OR = 1.612.54), and the likelihood of drivers license revocation showed near-significant increases at all frequencies of risk drinking. Frequency of risk drinking interacted with volume of intake on non-risk drinking days in predicting alcohol abuse and illicit drug use and with duration of drinking in predicting alcohol dependence. Risk drinking poses a threat of many types of harm, both directly and indirectly through its association with smoking initiation and nicotine dependence. These findings have illustrative value for prevention programs, and they indicate that frequent risk drinking is a strong marker for alcoholism. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Dawson, Deborah A AU - Li, Ting-Kai AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA ddawson@mail.nih.gov Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 62 EP - 72 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 95 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Risk drinking KW - Prospective risk KW - Smoking KW - Health risks KW - Alcohol abuse KW - Risk behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57254869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=A+prospective+study+of+risk+drinking%3A+At+risk+for+what%3F&rft.au=Dawson%2C+Deborah+A%3BLi%2C+Ting-Kai%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2008-05-01&rft.volume=95&rft.issue=1-2&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.12.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Alcohol abuse; Risk behaviour; Health risks; Smoking DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.12.007 ER - TY - JOUR T1 - Psychosocial Processes Underlying Smoking: Still More to Learn AN - 57253719; 200819117 AB - As reflected in the articles in this issue of Health Psychology, numerous questions remain to be answered concerning the complex psychological processes that determine tobacco use and cessation. Furthermore, the articles exemplify the value of employing a variety of research designs to address the myriad of unanswered questions. In the domain of the health cognition, laboratory experiments continue to play an essential role in teasing apart causal mechanisms and pathways to persuasion and motivation (Lopez et al., 2008; Rhodes et al., 2008). These phenomena can then be studied in the field to validate and replicate the findings in naturalistic contexts (Catley & Grobe, 2008). Theoretically derived hypotheses can also be tested within the context of interventions (Fuglestad, Rothman, & Jeffery, 2008; Hertel et al., 2008; Schumann et al., 2008). Cohort studies that include extensive measures of psychosocial functioning and social relationships, such as the National Longitudinal Study of Adolescent Health, have been especially important in understanding risk factors, pathways, and comorbidities associated with multiple health risk behaviors, including smoking (McCaffery et al., 2008). The importance of social, political and cultural context on individual-level behavior is reflected in studies of low-income populations (Nollen et al., 2008) and in international surveys (Yong & Borland, 2008). Finally, it is critical that systematic evidence reviews continue to be supported and conducted to ensure that interventions and public health policies are informed by the current state of the science (Webb, 2008). Webb's (2008) review of research concerning cessation in African American smokers complements the recent release of the new Public Health Service clinical guideline on smoking cessation (Fiore et al., 2008), which relied on a broad review of the enormous literature on cessation, and should be required reading for every clinical practitioner. [Copyright 2008 The American Psychological Association.] JF - Health Psychology AU - Croyle, Robert T AU - Backinger, Cathy L AD - National Cancer Institute, 6130 Executive Blvd., Room 6138, Bethesda, MD 20892 croyler@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - S185 EP - S186 PB - American Psychological Association, Washington DC VL - 27 IS - 3 SN - 0278-6133, 0278-6133 KW - Smoking KW - Interventions KW - Cessation KW - Psychosocial factors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Psychosocial+Processes+Underlying+Smoking%3A+Still+More+to+Learn&rft.au=Croyle%2C+Robert+T%3BBackinger%2C+Cathy+L&rft.aulast=Croyle&rft.aufirst=Robert&rft.date=2008-05-01&rft.volume=27&rft.issue=3&rft.spage=S185&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2Fa0012916 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Cessation; Smoking; Interventions; Psychosocial factors DO - http://dx.doi.org/10.1037/a0012916 ER - TY - JOUR T1 - Generalization of conditioned fear-potentiated startle in humans: Experimental validation and clinical relevance AN - 57252665; 200816276 AB - Though generalization of conditioned fear has been implicated as a central feature of pathological anxiety, surprisingly little is known about the psychobiology of this learning phenomenon in humans. Whereas animal work has frequently applied methods to examine generalization gradients to study the gradual weakening of the conditioned-fear response as the test stimulus increasingly differs from the conditioned stimulus (CS), to our knowledge no psychobiological studies of such gradients have been conducted in humans over the last 40 years. The current effort validates an updated generalization paradigm incorporating more recent methods for the objective measurement of anxiety (fear-potentiated startle). The paradigm employs 10, quasi-randomly presented, rings of gradually increasing size with extremes serving as CS+ and CS-. The eight rings of intermediary size serve as generalization stimuli (GSs) and create a continuum-of-similarity from CS+ to CS-. Both startle data and online self-report ratings demonstrate continuous decreases in generalization as the presented stimulus becomes less similar to the CS+. The current paradigm represents an updated and efficacious tool with which to study fear generalization-a central, yet understudied conditioning-correlate of pathologic anxiety. [Copyright 2008 Elsevier Ltd.] JF - Behaviour Research and Therapy AU - Lissek, Shmuel AU - Biggs, Arter L AU - Rabin, Stephanie J AU - Cornwell, Brian R AU - Alvarez, Ruben P AU - Pine, Daniel S AU - Grillon, Christian AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, Intramural Research Program, NIH, DHHS, 15K North Drive, Rm# 200, Bethesda, MD 20892-2670, USA lisseks@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 678 EP - 687 PB - Elsevier, Amsterdam The Netherlands VL - 46 IS - 5 SN - 0005-7967, 0005-7967 KW - Fear-potentiated startle KW - Stimulus generalization KW - Fear-conditioning KW - Anxiety disorders KW - Startle response KW - Conditioning KW - Fear KW - Stimulus KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57252665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=Generalization+of+conditioned+fear-potentiated+startle+in+humans%3A+Experimental+validation+and+clinical+relevance&rft.au=Lissek%2C+Shmuel%3BBiggs%2C+Arter+L%3BRabin%2C+Stephanie+J%3BCornwell%2C+Brian+R%3BAlvarez%2C+Ruben+P%3BPine%2C+Daniel+S%3BGrillon%2C+Christian&rft.aulast=Lissek&rft.aufirst=Shmuel&rft.date=2008-05-01&rft.volume=46&rft.issue=5&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.1016%2Fj.brat.2008.02.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Stimulus; Fear; Conditioning; Anxiety disorders; Startle response DO - http://dx.doi.org/10.1016/j.brat.2008.02.005 ER - TY - JOUR T1 - Reduced Bone Cortical Thickness in Boys with Autism or Autism Spectrum Disorder AN - 57244960; 200821706 AB - Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4-8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced a progressive fall-off (p = .02): +3.1 - 4.7%, -6.5 - 4.0%, -16.6 - 3.4%, -19.4 - 3.7%, -24.1 - 4.4%, at ages 4-8, respectively, adjusting for height. The 12% of the boys on casein-free diets had an overall % deviation of -18.9 - 3.7%, nearly twice that of boys on minimally restricted or unrestricted diets (-10.5 - 1.3%, p < .04), although even for boys on minimally restricted or unrestricted diets the % deviation was highly significant (p < .001). Our data suggest that the bone development of autistic boys should be monitored as part of routine care, especially if they are on casein-free diets. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Hediger, Mary L AU - England, Lucinda J AU - Molloy, Cynthia A AU - Yu, Kai F AU - Manning-Courtney, Patricia AU - Mills, James L AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health (DESPR, NICHD, NIH), Department of Health and Human Services, Bldg 6100, Rm 7B03, MSC 7510, 9000 Rockville Pike, Bethesda, MD 20892-7510, USA hedigerm@exchange.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 848 EP - 856 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 5 SN - 0162-3257, 0162-3257 KW - Bones KW - Diet KW - Autistic children KW - Child development KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57244960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Reduced+Bone+Cortical+Thickness+in+Boys+with+Autism+or+Autism+Spectrum+Disorder&rft.au=Hediger%2C+Mary+L%3BEngland%2C+Lucinda+J%3BMolloy%2C+Cynthia+A%3BYu%2C+Kai+F%3BManning-Courtney%2C+Patricia%3BMills%2C+James+L&rft.aulast=Hediger&rft.aufirst=Mary&rft.date=2008-05-01&rft.volume=38&rft.issue=5&rft.spage=848&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-007-0453-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Autistic children; Autistic spectrum disorders; Bones; Child development; Diet DO - http://dx.doi.org/10.1007/s10803-007-0453-6 ER - TY - JOUR T1 - What should research participants understand to understand they are participants in research? AN - 37042850; 3805261 AB - To give valid informed consent to participate in clinical research, potential participants should understand the risks, potential benefits, procedures, and alternatives. Potential participants also should understand that they are being invited to participate in research. Yet it is unclear what potential participants need to understand to satisfy this particular requirement. As a result, it is unclear what additional information investigators should disclose about the research; and it is also unclear when failures of understanding in this respect undermine the validity of potential participants' informed consent. An analysis of individuals' interests suggests that potential participants need to understand three additional facts to understand that they are being invited to participate in research: 1) research contribution: those who enroll in the study will be contributing to a project designed to gather generalizable knowledge to benefit others in the future; 2) research relationship: the investigators will rely on participants' efforts to gather the generalizable knowledge to benefit others; and 3) research impact: the extent to which participating in the study will alter what participants do and what happens to them. Reprinted by permission of Blackwell Publishers JF - Bioethics AU - Wendler, David AU - Grady, Christine AD - National Institutes of Health Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 203 EP - 208 VL - 22 IS - 4 SN - 0269-9702, 0269-9702 KW - Anthropology KW - Sociology KW - Informed consent KW - Risk KW - Medical sociology KW - Information acquisition KW - Medical research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37042850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioethics&rft.atitle=What+should+research+participants+understand+to+understand+they+are+participants+in+research%3F&rft.au=Wendler%2C+David%3BGrady%2C+Christine&rft.aulast=Wendler&rft.aufirst=David&rft.date=2008-05-01&rft.volume=22&rft.issue=4&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Bioethics&rft.issn=02699702&rft_id=info:doi/10.1111%2Fj.1467-8519.2008.00632.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7886 10902; 6516; 11035; 7887 12008 DO - http://dx.doi.org/10.1111/j.1467-8519.2008.00632.x ER - TY - JOUR T1 - Maternal responsiveness to young children at three ages: longitudinal analysis of a multidimensional, modular, and specific parenting construct AN - 36896860; 3552465 AB - Responsiveness defines the prompt, contingent, and appropriate reactions parents display to their children in the context of everyday exchanges. Maternal responsiveness occupies a theoretically central position in developmental science and possesses meaningful predictive validity over diverse domains of children's development, yet basic psychometric features of maternal responsiveness are still poorly understood. In this prospective longitudinal study, the authors examined structure, individual variation, and continuity of multiple dimensions of responsiveness in 40 mothers to their infants' activities at 10, 14, and 21 months during natural home-based play interactions. Both age-general and age-specific patterns emerged in maternal responding. The study's developmental results support the multidimensionality, modularity, and specificity of this central parenting construct. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Bornstein, Marc H AU - Tamis-LeMonda, Catherine S AU - Hahn, Chun-shin AU - Haynes, O Maurice AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development ; New York University Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 867 EP - 874 VL - 44 IS - 3 SN - 0012-1649, 0012-1649 KW - Sociology KW - Infancy KW - Parenting KW - Parent-child relations KW - Child rearing KW - Child development KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36896860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=Maternal+responsiveness+to+young+children+at+three+ages%3A+longitudinal+analysis+of+a+multidimensional%2C+modular%2C+and+specific+parenting+construct&rft.au=Bornstein%2C+Marc+H%3BTamis-LeMonda%2C+Catherine+S%3BHahn%2C+Chun-shin%3BHaynes%2C+O+Maurice&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2008-05-01&rft.volume=44&rft.issue=3&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.44.3.867 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 9183; 9178 4777 6093 6823; 6490 2211 652 5676 646 6091 2212; 2197 2212 6075 3483; 2206 2212 DO - http://dx.doi.org/10.1037/0012-1649.44.3.867 ER - TY - JOUR T1 - Mother-child emotional availability in ecological perspective: three countries, two regions, two genders AN - 36892744; 3552450 AB - This study used a cross-national framework to examine country, region, and gender differences in emotional availability (EA), a prominent index of mutual socioemotional adaptation in the parent-child dyad. Altogether 220 Argentine, Italian, and U.S. mothers and their daughters and sons from both rural and metropolitan areas took part in home observations when the children were 20 months old. In terms of country, Italian mothers were more sensitive and optimally structuring, and Italian children were more responsive and involving, than Argentine and U.S. dyads. In terms of region, rural mothers were more intrusive than metropolitan mothers, and boys from metropolitan areas were more responsive than boys from rural areas. In terms of gender, mothers of girls were more sensitive and optimally structuring than mothers of boys, and daughters were more responsive and involving than sons. Understanding how country, region, and gender influence EA exposes forces that shape child development, parent-infant interaction, and family systems. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Bornstein, Marc H AU - Putnick, Diane L AU - Heslington, Marianne AU - Gini, Motti AU - Suwalsky, Joan T.D. AU - Venuti, Paola AU - Falco, Simona de AU - Giusti, Zeno AU - Galperín, Celia Zingman de AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 666 EP - 680 VL - 44 IS - 3 SN - 0012-1649, 0012-1649 KW - Sociology KW - Culture KW - Infancy KW - Parent-child relations KW - U.S.A. KW - Child development KW - Developmental psychology KW - Child health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36892744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=Mother-child+emotional+availability+in+ecological+perspective%3A+three+countries%2C+two+regions%2C+two+genders&rft.au=Bornstein%2C+Marc+H%3BPutnick%2C+Diane+L%3BHeslington%2C+Marianne%3BGini%2C+Motti%3BSuwalsky%2C+Joan+T.D.%3BVenuti%2C+Paola%3BFalco%2C+Simona+de%3BGiusti%2C+Zeno%3BGalper%C3%ADn%2C+Celia+Zingman+de&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2008-05-01&rft.volume=44&rft.issue=3&rft.spage=666&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.44.3.666 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 2197 2212 6075 3483; 9178 4777 6093 6823; 6490 2211 652 5676 646 6091 2212; 2199 5772; 3198; 433 293 14 DO - http://dx.doi.org/10.1037/0012-1649.44.3.666 ER - TY - JOUR T1 - High Rates of Sex with Men among High-Risk, Heterosexually-Identified Men in Low-Income, Coastal Peru AN - 211254848; 17377837 AB - In this paper we describe sex with men, including the frequency of sex and unprotected sex, among high-risk, heterosexually-identified men in urban, low-income, coastal Peru. During 2001-2002, a random community-based sample of these men was administered an epidemiologic survey collecting sexual risk behavior data. Among the 924 high-risk heterosexually-identified men, 131 (14.2%) reported at least one male partner in the past 6 months. Of these, 113 (86.3%) reported male and female partners and among those with partners of both sexes, 84.2% and 57.0% of sex acts with female and male partners, respectively, were unprotected, (RR 1.48, 95% CI = 1.31-1.68). We observed a high rate of recent bisexual behavior compared to past studies showing frequent, unprotected sex with male and female partners. This population has substantial potential to act as a bridge population between and their male and female partners and should be addressed by prevention programs. [PUBLICATION ABSTRACT] JF - AIDS and Behavior AU - Fernandez, Percy AU - Klausner, Jeffrey D AU - Coates, Thomas J AU - Cáceres, Carlos F Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 483 EP - 91 CY - New York PB - Springer Science & Business Media VL - 12 IS - 3 SN - 10907165 KW - Psychology KW - Socioeconomic Factors KW - Demography KW - Risk Factors KW - Humans KW - Adult KW - Incidence KW - Sexual Behavior -- psychology KW - Male KW - Catchment Area (Health) KW - Prevalence KW - Peru -- epidemiology KW - Risk-Taking KW - Homosexuality, Male -- statistics & numerical data KW - Coitus KW - Heterosexuality -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/211254848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=High+Rates+of+Sex+with+Men+among+High-Risk%2C+Heterosexually-Identified+Men+in+Low-Income%2C+Coastal+Peru&rft.au=Fernandez%2C+Percy%3BKlausner%2C+Jeffrey+D%3BCoates%2C+Thomas+J%3BC%C3%A1ceres%2C+Carlos+F&rft.aulast=Fernandez&rft.aufirst=Percy&rft.date=2008-05-01&rft.volume=12&rft.issue=3&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-007-9221-z LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2008 N1 - Last updated - 2014-09-25 N1 - CODEN - AIBEFC DO - http://dx.doi.org/10.1007/s10461-007-9221-z ER - TY - JOUR T1 - Neurophysiological and genetic distinctions between pure and comorbid anxiety disorders AN - 21111326; 11311842 AB - Anxiety disorders are often comorbid with major depression (MD) and alcohol use disorders (AUD). Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-derived neurotrophic factor (BDNF Val66Met) genes have been implicated in the neurobiology of anxiety and depression. We hypothesized that attentional response and working memory (auditory P300 event-related potential and Weschler Adult Intelligence Scale, Revised digit symbol scores) as well as genetic vulnerability would differ between pure anxiety disorders and comorbid anxiety. Our study sample comprised 249 community-ascertained men and women with lifetime DSM-III-R diagnoses. We analyzed groups of participants with pure anxiety disorders, pure MD, pure AUD, comorbid anxiety, and no psychiatric disorder. Participants were well at the time of testing; state anxiety and depressed mood measures were at most only mildly elevated. Individuals with pure anxiety disorders had elevated P300 amplitudes (P=0.0004) and higher digit symbol scores (P<0.0001) compared with all the other groups. Individuals with comorbid anxiety had the greatest proportion of COMT Met158 and BDNF Met66 alleles (P=0.009) as well as higher harm avoidance-neuroticism (P<0.0005) than all other groups. Our results suggest that there may be two vulnerability factors for anxiety disorders with differing genetic susceptibility: (a) heightened attention and better working memory with mildly elevated anxiety-neuroticism, a constellation that may be protective against other psychopathology; and (b) poorer attention and working memory with greater anxiety-neuroticism, a constellation that may also increase vulnerability to AUD and MD. This refinement of the anxiety phenotype may have implications for therapeutic interventions. Depression and Anxiety 0:1-10, 2007. Published 2007 Wiley-Liss, Inc. JF - Depression and Anxiety (Hoboken) AU - Enoch, Mary-Anne AU - White, Kenneth V AU - Waheed, Juwaria AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, maenoch@niaaa.nih.gov Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 383 EP - 392 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 25 IS - 5 SN - 1091-4269, 1091-4269 KW - Genetics Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Brain-derived neurotrophic factor KW - Alcohol KW - Depression KW - Anxiety KW - Gene polymorphism KW - Therapeutic applications KW - Event-related potentials KW - depression KW - Short term memory KW - Mood KW - Auditory evoked potentials KW - Intelligence KW - Nervous system KW - Mental disorders KW - Catechol O-methyltransferase KW - intervention KW - alcohols KW - vulnerability KW - Psychopathology KW - mental disorders KW - Attention KW - intelligence KW - G 07880:Human Genetics KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21111326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+Anxiety+%28Hoboken%29&rft.atitle=Neurophysiological+and+genetic+distinctions+between+pure+and+comorbid+anxiety+disorders&rft.au=Enoch%2C+Mary-Anne%3BWhite%2C+Kenneth+V%3BWaheed%2C+Juwaria%3BGoldman%2C+David&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2008-05-01&rft.volume=25&rft.issue=5&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Depression+and+Anxiety+%28Hoboken%29&rft.issn=10914269&rft_id=info:doi/10.1002%2Fda.20378 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Brain-derived neurotrophic factor; Depression; Anxiety; Gene polymorphism; Therapeutic applications; Event-related potentials; Short term memory; Auditory evoked potentials; Mood; Intelligence; Mental disorders; Nervous system; Catechol O-methyltransferase; alcohols; Psychopathology; Attention; Alcohol; intervention; vulnerability; mental disorders; depression; intelligence DO - http://dx.doi.org/10.1002/da.20378 ER - TY - JOUR T1 - A Tightly Regulated Surface Protein of Borrelia burgdorferi Is Not Essential to the Mouse-Tick Infectious Cycle AN - 21022600; 8198716 AB - Borrelia burgdorferi synthesizes a variety of differentially regulated outer surface lipoproteins in the tick vector and in vertebrate hosts. Among these is OspD, a protein that is highly induced in vitro by conditions that mimic the tick environment. Using genetically engineered strains in which ospD is deleted, we demonstrate that this protein is not required for B. burgdorferi survival and infectivity in either the mouse or the tick. However, examination of both transcript levels and protein expression indicates that OspD expression is limited to a discrete window of time during B. burgdorferi replication within the tick. This time frame corresponds to tick detachment from the host following feeding, and expression of OspD continues during tick digestion of the blood meal but is low or undetectable after the tick has molted. The high level of OspD production correlates to the highest cell densities that B. burgdorferi is known to reach in vivo. Although OspD is nonessential to the infectious cycle of B. burgdorferi, the tight regulation of expression suggests a beneficial contribution of OspD to the spirochete during bacterial replication within the tick midgut. JF - Infection and Immunity AU - Stewart, Philip E AU - Bestor, Aaron AU - Cullen, Jonah N AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th St., Hamilton, Montana 59840 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1970 EP - 1978 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 5 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Feeding KW - Borrelia burgdorferi KW - Lymphocytes B KW - Replication KW - Ixodidae KW - Cell density KW - Transcription KW - Survival KW - Blood meals KW - Digestion KW - Spirochetes KW - Infectivity KW - Genetic engineering KW - Lipoproteins KW - Midgut KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering KW - A 01450:Environmental Pollution & Waste Treatment KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21022600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=A+Tightly+Regulated+Surface+Protein+of+Borrelia+burgdorferi+Is+Not+Essential+to+the+Mouse-Tick+Infectious+Cycle&rft.au=Stewart%2C+Philip+E%3BBestor%2C+Aaron%3BCullen%2C+Jonah+N%3BRosa%2C+Patricia+A&rft.aulast=Stewart&rft.aufirst=Philip&rft.date=2008-05-01&rft.volume=76&rft.issue=5&rft.spage=1970&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Feeding; Replication; Lymphocytes B; Cell density; Survival; Transcription; Blood meals; Digestion; Spirochetes; Infectivity; Genetic engineering; Lipoproteins; Midgut; Borrelia burgdorferi; Ixodidae ER - TY - JOUR T1 - Adeno-associated virus integration: virus versus vector AN - 21022495; 8220446 AB - Although a large percentage of the world population is seropositive for exposure to various strains of adeno-associated virus (AAV), a human parvovirus, AAV has never been identified as an etiologic agent of human disease. Most likely contributing to the pronounced lack of pathogenicity is the fact that AAV is a naturally 'defective' virus that requires a helper virus for productive replication of its genome. Another unusual aspect of wild-type AAV biology is the ability of the virus to establish latent infection by preferential integration of its genome into a specific locus of human chromosome 19. Site-specific integration was a major impetus for the development of recombinant AAV vectors, which typically lack all AAV coding sequences. It was soon realized, however, that expression of at least one species of the virally encoded initiator proteins, Rep78 or Rep68, is necessary for targeted integration of AAV-derived DNA constructs to occur. This article will present a chronological outline of studies characterizing site-specific integration of wild-type AAV sequences and the quasi-random target site selection observed with recombinant AAV vectors. JF - Gene Therapy AU - Smith, R H AD - Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, Bethesda, MD, USA, smithr@nhlbi.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 817 EP - 822 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 11 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - AAV KW - adeno-associated virus KW - integration KW - Genomes KW - Site selection KW - Integration KW - Latent infection KW - Gene therapy KW - Pathogenicity KW - Replication KW - DNA KW - chromosome 19 KW - Parvovirus KW - Adeno-associated virus KW - W 30905:Medical Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21022495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Adeno-associated+virus+integration%3A+virus+versus+vector&rft.au=Smith%2C+R+H&rft.aulast=Smith&rft.aufirst=R&rft.date=2008-05-01&rft.volume=15&rft.issue=11&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2008.55 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Site selection; Genomes; Latent infection; Integration; Pathogenicity; Gene therapy; Replication; chromosome 19; DNA; Parvovirus; Adeno-associated virus DO - http://dx.doi.org/10.1038/gt.2008.55 ER - TY - JOUR T1 - Toward exascale production of recombinant adeno-associated virus for gene transfer applications AN - 21004295; 8220447 AB - To gain acceptance as a medical treatment, adeno-associated virus (AAV) vectors require a scalable and economical production method. Recent developments indicate that recombinant AAV (rAAV) production in insect cells is compatible with current good manufacturing practice production on an industrial scale. This platform can fully support development of rAAV therapeutics from tissue culture to small animal models, to large animal models, to toxicology studies, to Phase I clinical trials and beyond. Efforts to characterize, optimize and develop insect cell-based rAAV production have culminated in successful bioreactor-scale production of rAAV, with total yields potentially capable of approaching the 'exa-(10 super(18)) scale.' These advances in large-scale AAV production will allow us to address specific catastrophic, intractable human diseases such as Duchenne muscular dystrophy, for which large amounts of recombinant vector are essential for successful outcome. JF - Gene Therapy AU - Cecchini, S AU - Negrete, A AU - Kotin, R M AD - Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, MD, USA, kotinr@nhlbi.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 823 EP - 830 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 11 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - rAAV KW - bioprocess KW - baculovirus KW - large scale KW - Sf9 KW - Duchenne's muscular dystrophy KW - Gene therapy KW - Insect cells KW - Animal models KW - Drug development KW - Tissue culture KW - Clinical trials KW - Adeno-associated virus KW - W 30905:Medical Applications KW - V 22310:Genetics, Taxonomy & Structure KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21004295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Toward+exascale+production+of+recombinant+adeno-associated+virus+for+gene+transfer+applications&rft.au=Cecchini%2C+S%3BNegrete%2C+A%3BKotin%2C+R+M&rft.aulast=Cecchini&rft.aufirst=S&rft.date=2008-05-01&rft.volume=15&rft.issue=11&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2008.61 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Duchenne's muscular dystrophy; Gene therapy; Insect cells; Animal models; Drug development; Tissue culture; Clinical trials; Adeno-associated virus DO - http://dx.doi.org/10.1038/gt.2008.61 ER - TY - JOUR T1 - Lactoferrin Acts as an Alarmin to Promote the Recruitment and Activation of APCs and Antigen-Specific Immune Responses AN - 20962144; 8200911 AB - Lactoferrin is an 80-kDa iron-binding protein present at high concentrations in milk and in the granules of neutrophils. It possesses multiple activities, including antibacterial, antiviral, antifungal, and even antitumor effects. Most of its antimicrobial effects are due to direct interaction with pathogens, but a few reports show that it has direct interactions with cells of the immune system. In this study, we show the ability of recombinant human lactoferrin (talactoferrin alfa (TLF)) to chemoattract monocytes. What is more, addition of TLF to human peripheral blood or monocyte-derived dendritic cell cultures resulted in cell maturation, as evidenced by up-regulated expression of CD80, CD83, and CD86, production of proinflammatory cytokines, and increased capacity to stimulate the proliferation of allogeneic lymphocytes. When injected into the mouse peritoneal cavity, lactoferrin also caused a marked recruitment of neutrophils and macrophages. Immunization of mice with OVA in the presence of TLF promoted Th1-polarized Ag-specific immune responses. These results suggest that lactoferrin contributes to the activation of both the innate and adaptive immune responses by promoting the recruitment of leukocytes and activation of dendritic cells. JF - Journal of Immunology AU - de la Rosa, Gonzalo AU - Yang, De AU - Tewary, Poonam AU - Varadhachary, Atul AU - Oppenheim, Joost J AD - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Fredrick, MD 21702. Basic Research Program, Science Applications International Corporation-Frederick, National Cancer Institute-Fredrick, MD 21702. Agennix, Houston, TX 77046 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 6868 EP - 6876 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 10 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Granules KW - Macrophages KW - Ovalbumin KW - CD83 antigen KW - Immune system KW - CD86 antigen KW - Cell culture KW - Lymphocytes KW - Cell activation KW - Leukocyte migration KW - Dendritic cells KW - CD80 antigen KW - Cytokines KW - Monocytes KW - Antigen-presenting cells KW - Milk KW - Peritoneum KW - Leukocytes (neutrophilic) KW - Peripheral blood KW - iron-binding protein KW - Pathogens KW - Immunization KW - Inflammation KW - lactoferrin KW - Antitumor activity KW - K 03350:Immunology KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20962144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Lactoferrin+Acts+as+an+Alarmin+to+Promote+the+Recruitment+and+Activation+of+APCs+and+Antigen-Specific+Immune+Responses&rft.au=de+la+Rosa%2C+Gonzalo%3BYang%2C+De%3BTewary%2C+Poonam%3BVaradhachary%2C+Atul%3BOppenheim%2C+Joost+J&rft.aulast=de+la+Rosa&rft.aufirst=Gonzalo&rft.date=2008-05-01&rft.volume=180&rft.issue=10&rft.spage=6868&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Granules; Ovalbumin; CD83 antigen; CD86 antigen; Immune system; Cell culture; Lymphocytes; Cell activation; Leukocyte migration; Dendritic cells; Cytokines; CD80 antigen; Antigen-presenting cells; Monocytes; Milk; Peritoneum; Leukocytes (neutrophilic); Peripheral blood; Pathogens; iron-binding protein; Immunization; Inflammation; lactoferrin; Antitumor activity ER - TY - JOUR T1 - Adoptive Cell Therapy for Patients with Melanoma, Using Tumor-Infiltrating Lymphocytes Genetically Engineered to Secrete Interleukin-2 AN - 20946667; 8307005 AB - Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) after lymphodepletion mediates regression in 50% of patients with metastatic melanoma. In vivo persistence and telomere length of the transferred cells correlate with antitumor response. In an attempt to prolong the in vivo survival of the transferred cells, TILs were genetically engineered to produce interleukin (IL)-2. In vitro, these transduced TILs secreted IL-2 while retaining tumor specificity and exhibited prolonged survival after IL-2 withdrawal. In a phase I/II clinical trial, seven evaluable patients received transduced TILs and one patient experienced a partial response associated with in vivo persistence of IL-2-transduced TILs in circulating lymphocytes. An additional five patients received transduced TILs in conjunction with IL-2 administration. Persistence of IL-2-transduced TILs was observed in three patients, including one partial responder. The transgene DNA as well as vector-derived IL-2 mRNA could be detected for 4 months in responding patients. The low response rate in this trial was possibly due to a reduction in telomere length in cells as a result of prolonged in vitro culture. In this study, insertion of the IL-2 gene into antitumor TILs increased their ability to survive after IL-2 withdrawal in vitro but did not increase their in vivo persistence or clinical effectiveness. JF - Human Gene Therapy AU - Heemskerk, B AU - Liu, K AU - Dudley, ME AU - Johnson, LA AU - Kaiser, A AU - Downey, S AU - Zheng, Z AU - Shelton, TE AU - Matsuda, K AU - Robbins, P F AU - Morgan, R A AU - Rosenberg, SA AD - Surgery Branch, National Cancer Institute, National Institutes of Health, CRC 3W-3940, 10 Center Drive, Bethesda, MD 20892-1201, USA, sar@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 496 EP - 510 VL - 19 IS - 5 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Interleukin 2 KW - Gene therapy KW - Cell culture KW - Tumor-infiltrating lymphocytes KW - Lymphocytes KW - Clinical trials KW - mRNA KW - Melanoma KW - Metastases KW - Telomeres KW - Insertion KW - Genetic engineering KW - DNA KW - Antitumor activity KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20946667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Adoptive+Cell+Therapy+for+Patients+with+Melanoma%2C+Using+Tumor-Infiltrating+Lymphocytes+Genetically+Engineered+to+Secrete+Interleukin-2&rft.au=Heemskerk%2C+B%3BLiu%2C+K%3BDudley%2C+ME%3BJohnson%2C+LA%3BKaiser%2C+A%3BDowney%2C+S%3BZheng%2C+Z%3BShelton%2C+TE%3BMatsuda%2C+K%3BRobbins%2C+P+F%3BMorgan%2C+R+A%3BRosenberg%2C+SA&rft.aulast=Heemskerk&rft.aufirst=B&rft.date=2008-05-01&rft.volume=19&rft.issue=5&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2007.0171 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Gene therapy; Interleukin 2; Tumor-infiltrating lymphocytes; Cell culture; Lymphocytes; Clinical trials; Melanoma; mRNA; Metastases; Telomeres; Insertion; Genetic engineering; DNA; Antitumor activity DO - http://dx.doi.org/10.1089/hum.2007.0171 ER - TY - JOUR T1 - Oral administration of dahi containing probiotic Lactobacillus acidophilus and Lactobacillus casei delayed the progression of streptozotocin-induced diabetes in rats AN - 20935971; 8334776 AB - In this study, the effect of dahi containing probiotic Lactobacillus acidophilus NCDC14 and Lactobacillus casei NCDC19 ( similar to 73 x 10 super(8) cfu/g) on progression of streptozotocin (STZ)-induced diabetes in rats (15 g/day/rat) for 28 days was investigated. Feeding of probiotic dahi significantly suppressed the incremental peaks and area under the curve and delayed reduction of insulin secretion during oral glucose tolerance test more than skim milk or control dahi. The feeding of milk products reduced the total cholesterol, triglycerides, LDL and VLDL-cholesterol and increased HDL-cholesterol levels (P < 0 times 05). Moreover, probiotic dahi significantly suppressed STZ-induced oxidative damage in pancreatic tissues by inhibiting the lipid peroxidation and formation of nitric oxide, and preserving antioxidant pool such as glutathione content and activities of superoxide dismutase, catalase and glutathione peroxidase. The results suggest that the supplementation of probiotic Lb. acidophilus and Lb. casei with dahi cultures increased the efficacy of dahi to suppress STZ-induced diabetes in rats by inhibiting depletion of insulin as well as preserving diabetic dyslipidemia, and inhibiting lipid peroxidation and nitrite formation. This may empower antioxidant system of beta -cells and may slow down the reduction of insulin and elevation of blood glucose levels. JF - Journal of Dairy Research AU - Yadav, H AU - Jain, S AU - Sinha, PR AD - Regenerative Biology Section, Diabetes Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Building 10, Clinical Research Center, West Laboratories, 5-5872, South Drive and Old Georgetown Road, Bethesda, MD 20892, USA, yadavh@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 189 EP - 195 VL - 75 IS - 2 SN - 0022-0299, 0022-0299 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Lactobacillus casei KW - Antioxidants KW - Secretion KW - Pancreas KW - Beta cells KW - Skim milk KW - Insulin KW - Supplementation KW - Lipoproteins (low density) KW - Milk products KW - Glutathione peroxidase KW - Superoxide dismutase KW - Triglycerides KW - Nitrite KW - Feeding KW - Lactobacillus acidophilus KW - Oral administration KW - probiotics KW - Cholesterol KW - Streptozocin KW - Lipid peroxidation KW - Catalase KW - Diabetes mellitus KW - Blood KW - Colony-forming cells KW - Dyslipidemia KW - Glucose tolerance KW - Nitric oxide KW - J 02410:Animal Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20935971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Dairy+Research&rft.atitle=Oral+administration+of+dahi+containing+probiotic+Lactobacillus+acidophilus+and+Lactobacillus+casei+delayed+the+progression+of+streptozotocin-induced+diabetes+in+rats&rft.au=Yadav%2C+H%3BJain%2C+S%3BSinha%2C+PR&rft.aulast=Yadav&rft.aufirst=H&rft.date=2008-05-01&rft.volume=75&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Journal+of+Dairy+Research&rft.issn=00220299&rft_id=info:doi/10.1017%2FS0022029908003129 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antioxidants; Pancreas; Secretion; Beta cells; Skim milk; Supplementation; Insulin; Lipoproteins (low density); Milk products; Superoxide dismutase; Glutathione peroxidase; Triglycerides; Nitrite; Feeding; probiotics; Oral administration; Cholesterol; Streptozocin; Catalase; Lipid peroxidation; Diabetes mellitus; Blood; Colony-forming cells; Dyslipidemia; Glucose tolerance; Nitric oxide; Lactobacillus casei; Lactobacillus acidophilus DO - http://dx.doi.org/10.1017/S0022029908003129 ER - TY - JOUR T1 - Human Dendritic Cell-Specific Intercellular Adhesion Molecule-Grabbing Nonintegrin (CD209) Is a Receptor for Yersinia pestis That Promotes Phagocytosis by Dendritic Cells AN - 20929766; 8198727 AB - Yersinia pestis is the etiologic agent of bubonic and pneumonic plagues. It is speculated that Y. pestis hijacks antigen-presenting cells (APCs), such as dendritic cells (DCs) and alveolar macrophages, in order to be delivered to lymph nodes. However, how APCs initially capture the bacterium remains uncharacterized. It is well known that HIV-1 uses human DC-specific intercellular adhesion molecule-grabbing nonintegrin (DC-SIGN) (CD209) receptor, expressed by APCs, to be captured and delivered to target cell, such as CD4 super(+) lymphocytes. Several gram-negative bacteria utilize their core lipopolysaccharides (LPS) as ligands to interact with the human DC-SIGN. Therefore, it is possible that Y. pestis, whose core LPS is naturally exposed, might exploit DC-SIGN to invade APCs. We demonstrate in this study that Y. pestis directly interacts with DC-SIGN and invades both DCs and alveolar macrophages. In contrast, when engineered to cover the core LPS, Y. pestis loses its ability to invade DCs, alveolar macrophages, and DC-SIGN-expressing transfectants. The interaction between Y. pestis and human DCs can be reduced by a combination treatment with anti-CD209 and anti-CD207 antibodies. This study shows that human DC-SIGN is a receptor for Y. pestis that promotes phagocytosis by DCs in vitro. JF - Infection and Immunity AU - Zhang, Pei AU - Skurnik, Mikael AU - Zhang, Shu-Sheng AU - Schwartz, Olivier AU - Kalyanasundaram, Ramaswamy AU - Bulgheresi, Silvia AU - He, Johnny J AU - Klena, John D AU - Hinnebusch, BJoseph AU - Chen, Tie AD - Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago (UIC), 1601 Parkview Avenue, Rockford, Illinois 61107. Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, Helsinki 00014, Finland. Virus and Immunity Group in the Department of Virology, Institut Pasteur, Paris, France. Faculty of Life Sciences, Department of Marine Biology, University of Vienna, Vienna, Austria. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202. School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2070 EP - 2079 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 5 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Yersinia pestis KW - Lymphocytes KW - Lymph nodes KW - Alveoli KW - Cell adhesion KW - Dendritic cells KW - CD4 antigen KW - Antibodies KW - DC-SIGN protein KW - Gram-negative bacteria KW - Human immunodeficiency virus 1 KW - Lipopolysaccharides KW - Antigen-presenting cells KW - Phagocytosis KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20929766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Human+Dendritic+Cell-Specific+Intercellular+Adhesion+Molecule-Grabbing+Nonintegrin+%28CD209%29+Is+a+Receptor+for+Yersinia+pestis+That+Promotes+Phagocytosis+by+Dendritic+Cells&rft.au=Zhang%2C+Pei%3BSkurnik%2C+Mikael%3BZhang%2C+Shu-Sheng%3BSchwartz%2C+Olivier%3BKalyanasundaram%2C+Ramaswamy%3BBulgheresi%2C+Silvia%3BHe%2C+Johnny+J%3BKlena%2C+John+D%3BHinnebusch%2C+BJoseph%3BChen%2C+Tie&rft.aulast=Zhang&rft.aufirst=Pei&rft.date=2008-05-01&rft.volume=76&rft.issue=5&rft.spage=2070&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Lymphocytes; Alveoli; Lymph nodes; Cell adhesion; Dendritic cells; Antibodies; CD4 antigen; DC-SIGN protein; Gram-negative bacteria; Lipopolysaccharides; Antigen-presenting cells; Phagocytosis; Human immunodeficiency virus 1; Yersinia pestis ER - TY - JOUR T1 - Cell-Nanofiber-Based Cartilage Tissue Engineering Using Improved Cell Seeding, Growth Factor, and Bioreactor Technologies AN - 20917929; 8508166 AB - Biodegradable nanofibrous scaffolds serving as an extracellular matrix substitute have been shown to be applicable for cartilage tissue engineering. However, a key challenge in using nanofibrous scaffolds for tissue engineering is that the small pore size limits the infiltration of cells, which may result in uneven cell distribution throughout the scaffold. This study describes an effective method of chondrocyte loading into nanofibrous scaffolds, which combines cell seeding, mixing, and centrifugation to form homogeneous, packed cell-nanofiber composites (CNCs). When the effects of different growth factors are compared, CNCs cultured in medium containing a combination of insulin-like growth factor-1 and transforming growth factor- beta 1 express the highest mRNA levels of collagen type II and aggrecan. Radiolabeling analyses confirm the effect on collagen and sulfated-glycosaminoglycans (sGAG) production. Histology reveals chondrocytes with typical morphology embedded in lacuna-like space throughout the entire structure of the CNC. Upon culturing using a rotary wall vessel bioreactor, CNCs develop into a smooth, glossy cartilage-like tissue, compared to a rough-surface tissue when maintained in a static environment Bioreactor-grown cartilage constructs produce more total collagen and sGAG, resulting in greater gain in net tissue weight, as well as express cartilage-associated genes, including collagen types II and IX, cartilage oligomeric matrix protein, and aggrecan. In addition, dynamic culture enhances the mechanical property of the engineered cartilage. Taken together, these results indicate the applicability of nanofibrous scaffolds, combined with efficient cell loading and bioreactor technology, for cell-based cartilage tissue engineering. JF - Tissue Engineering, Part A: Tissue Engineering AU - Li, W-J AU - Jiang, Y J AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1523, MSC 8022, Bethesda, MD 20892-8022, USA, tuanr@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 639 EP - 648 VL - 14 IS - 5 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Cartilage oligomeric matrix protein KW - Insulin-like growth factor I KW - Cartilage KW - Chondrocytes KW - Cell culture KW - Tissue engineering KW - Transforming growth factor-^b1 KW - scaffolds KW - mRNA KW - Centrifugation KW - Pores KW - Extracellular matrix KW - Bioreactors KW - Collagen (type II) KW - Growth factors KW - aggrecan KW - Mechanical properties KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20917929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Cell-Nanofiber-Based+Cartilage+Tissue+Engineering+Using+Improved+Cell+Seeding%2C+Growth+Factor%2C+and+Bioreactor+Technologies&rft.au=Li%2C+W-J%3BJiang%2C+Y+J%3BTuan%2C+R+S&rft.aulast=Li&rft.aufirst=W-J&rft.date=2008-05-01&rft.volume=14&rft.issue=5&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ftea.2007.0136 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tissue engineering; Cartilage; scaffolds; Bioreactors; Chondrocytes; Growth factors; aggrecan; Cartilage oligomeric matrix protein; Mechanical properties; mRNA; Cell culture; Centrifugation; Pores; Insulin-like growth factor I; Transforming growth factor-^b1; Extracellular matrix; Collagen (type II) DO - http://dx.doi.org/10.1089/tea.2007.0136 ER - TY - JOUR T1 - Brucella Intracellular Replication Requires Trafficking Through the Late Endosomal/Lysosomal Compartment AN - 20895923; 8227697 AB - Upon entry into mammalian cells, the intracellular pathogen Brucella abortus resides within a membrane-bound compartment, the Brucella-containing vacuole (BCV), the maturation of which is controlled by the bacterium to generate a replicative organelle derived from the endoplasmic reticulum (ER). Prior to reaching the ER, Brucella is believed to ensure its intracellular survival by inhibiting fusion of the intermediate BCV with late endosomes and lysosomes, although such BCVs are acidic and accumulate the lysosomal-associated membrane protein (LAMP-1). Here, we have further examined the nature of intermediate BCVs using confocal microscopy and live cell imaging. We show that BCVs rapidly acquire several late endocytic markers, including the guanosine triphosphatase Rab7 and its effector Rab-interacting lysosomal protein (RILP), and are accessible to fluid-phase markers either delivered to the whole endocytic pathway or preloaded to lysosomes, indicating that BCVs interact with late endosomes and lysosomes. Consistently, intermediate BCVs are acidic and display proteolytic activity up to 12h post-infection. Expression of dominant-negative Rab7 or overexpression of RILP significantly impaired the ability of bacteria to convert their vacuole into an ER-derived organelle and replicate, indicating that BCV maturation requires interactions with functional late endosomal/lysosomal compartments. In cells expressing dominant-negative Rab7[T22N], BCVs remained acidic, yet displayed decreased fusion with lysosomes. Taken together, these results demonstrate that BCVs traffic along the endocytic pathway and fuse with lysosomes, and such fusion events are required for further maturation of BCVs into an ER-derived replicative organelle. JF - Traffic AU - Starr, Tregei AU - Ng, Tony W AU - Wehrly, Tara D AU - Knodler, Leigh A AU - Celli, Jean AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA, jcelli@niaid.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 678 EP - 694 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 5 KW - Microbiology Abstracts B: Bacteriology KW - Brucella KW - endocytic pathway KW - live cell imaging KW - pathogenesis KW - phagosome maturation KW - Rab7 KW - vacuole acidification KW - Proteolysis KW - Replication KW - Pathogens KW - Membrane proteins KW - LAMP-1 protein KW - imaging KW - Triphosphatase KW - Endoplasmic reticulum KW - endosomes KW - Mammalian cells KW - Confocal microscopy KW - Vacuoles KW - Lysosomal protein KW - Brucella abortus KW - Guanosine KW - Organelles KW - Lysosomes KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20895923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic&rft.atitle=Brucella+Intracellular+Replication+Requires+Trafficking+Through+the+Late+Endosomal%2FLysosomal+Compartment&rft.au=Starr%2C+Tregei%3BNg%2C+Tony+W%3BWehrly%2C+Tara+D%3BKnodler%2C+Leigh+A%3BCelli%2C+Jean&rft.aulast=Starr&rft.aufirst=Tregei&rft.date=2008-05-01&rft.volume=9&rft.issue=5&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Traffic&rft.issn=1600-0854&rft_id=info:doi/10.1111%2Fj.1600-0854.2008.00718.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Proteolysis; Replication; Membrane proteins; Pathogens; imaging; LAMP-1 protein; Endoplasmic reticulum; Triphosphatase; endosomes; Mammalian cells; Vacuoles; Confocal microscopy; Lysosomal protein; Guanosine; Organelles; Lysosomes; Brucella abortus DO - http://dx.doi.org/10.1111/j.1600-0854.2008.00718.x ER - TY - JOUR T1 - The DNA-binding domain as a functional indicator: the case of the AraC/XylS family of transcription factors AN - 20888068; 8158759 AB - The AraC/XylS family of transcription factors, which include proteins that are involved in the regulation of diverse biological processes, has been of considerable interest recently and has been constantly expanding by means of in silico predictions and experimental analysis. In this work, using a HMM based on the DNA binding domain of 58 experimentally characterized proteins from the AraC/XylS (A/X), 1974 A/X proteins were found in 149 out of 212 bacterial genomes. This domain was used as a template to generate a phylogenetic tree and as a tool to predict the putative regulatory role of the new members of this family based on their proximity to a particular functional cluster in the tree. Based on this approach we assigned a functional regulatory role for 75% of the TFs dataset. Of these, 33.7% regulate genes involved in carbon-source catabolism, 9.6% global metabolism, 8.3% nitrogen metabolism, 2.9% adaptation responses, 8.9% stress responses, and 11.7% virulence. The abundance of TFs involved in the regulation of metabolic processes indicates that bacteria have optimized their regulatory systems to control energy uptake. In contrast, the lower percentage of TFs required for stress, adaptation and virulence regulation reflects the specialization acquired by each subset of TFs associated with those processes. This approach would be useful in assigning regulatory roles to uncharacterized members of other transcriptional factor families and it might facilitate their experimental analysis. JF - Genetica AU - Ibarra, JAntonio AU - Perez-Rueda, Ernesto AU - Segovia, Lorenzo AU - Puente, JLuis AD - Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico, ibarraa@niaid.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 65 EP - 76 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 133 IS - 1 SN - 0016-6707, 0016-6707 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Phylogeny KW - Genomes KW - Adaptations KW - Abundance KW - Specialization KW - Stress KW - Virulence KW - double prime X protein KW - Energy KW - Transcription factors KW - DNA KW - Metabolism KW - Nitrogen KW - J 02320:Cell Biology KW - N 14835:Protein-Nucleic Acids Association KW - A 01390:Forestry KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20888068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetica&rft.atitle=The+DNA-binding+domain+as+a+functional+indicator%3A+the+case+of+the+AraC%2FXylS+family+of+transcription+factors&rft.au=Ibarra%2C+JAntonio%3BPerez-Rueda%2C+Ernesto%3BSegovia%2C+Lorenzo%3BPuente%2C+JLuis&rft.aulast=Ibarra&rft.aufirst=JAntonio&rft.date=2008-05-01&rft.volume=133&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Genetica&rft.issn=00166707&rft_id=info:doi/10.1007%2Fs10709-007-9185-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Phylogeny; Adaptations; Abundance; Stress; Specialization; Virulence; double prime X protein; Transcription factors; Energy; DNA; Metabolism; Nitrogen DO - http://dx.doi.org/10.1007/s10709-007-9185-y ER - TY - JOUR T1 - Sustained Axenic Metabolic Activity by the Obligate Intracellular Bacterium Coxiella burnetii AN - 20881122; 8199472 AB - Growth of Coxiella burnetii, the agent of Q fever, is strictly limited to colonization of a viable eukaryotic host cell. Following infection, the pathogen replicates exclusively in an acidified (pH 4.5 to 5) phagolysosome-like parasitophorous vacuole. Axenic (host cell free) buffers have been described that activate C. burnetii metabolism in vitro, but metabolism is short-lived, with bacterial protein synthesis halting after a few hours. Here, we describe a complex axenic medium that supports sustained (>24 h) C. burnetii metabolic activity. As an initial step in medium development, several biological buffers (pH 4.5) were screened for C. burnetii metabolic permissiveness. Based on [ super(35)S]Cys-Met incorporation, C. burnetii displayed optimal metabolic activity in citrate buffer. To compensate for C. burnetii auxotrophies and other potential metabolic deficiencies, we developed a citrate buffer-based medium termed complex Coxiella medium (CCM) that contains a mixture of three complex nutrient sources (neopeptone, fetal bovine serum, and RPMI cell culture medium). Optimal C. burnetii metabolism occurred in CCM with a high chloride concentration (140 mM) while the concentrations of sodium and potassium had little effect on metabolism. CCM supported prolonged de novo protein and ATP synthesis by C. burnetii (>24 h). Moreover, C. burnetii morphological differentiation was induced in CCM as determined by the transition from small-cell variant to large-cell variant. The sustained in vitro metabolic activity of C. burnetii in CCM provides an important tool to investigate the physiology of this organism including developmental transitions and responses to antimicrobial factors associated with the host cell. JF - Journal of Bacteriology AU - Omsland, Anders AU - Cockrell, Diane C AU - Fischer, Elizabeth R AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites. Microscopy Unit, Research Technology Section, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 3203 EP - 3212 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 9 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Protein biosynthesis KW - ATP KW - Potassium KW - Cell culture KW - Chloride KW - Auxotrophy KW - Pathogens KW - Infection KW - double prime Q fever KW - Sodium KW - parasitophorous vacuole KW - Coxiella burnetii KW - Differentiation KW - Colonization KW - Protein turnover KW - Nutrient sources KW - pH effects KW - Metabolism KW - Citric acid KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20881122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Sustained+Axenic+Metabolic+Activity+by+the+Obligate+Intracellular+Bacterium+Coxiella+burnetii&rft.au=Omsland%2C+Anders%3BCockrell%2C+Diane+C%3BFischer%2C+Elizabeth+R%3BHeinzen%2C+Robert+A&rft.aulast=Omsland&rft.aufirst=Anders&rft.date=2008-05-01&rft.volume=190&rft.issue=9&rft.spage=3203&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein biosynthesis; Potassium; ATP; Chloride; Cell culture; Pathogens; Auxotrophy; Infection; double prime Q fever; parasitophorous vacuole; Sodium; Colonization; Differentiation; Protein turnover; Nutrient sources; pH effects; Metabolism; Citric acid; Coxiella burnetii; Bacteria ER - TY - JOUR T1 - Endogenous sex hormones and the risk of prostate cancer: A prospective study AN - 20873358; 8367572 AB - Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in epidemiologic studies. We conducted a nested case-control study with prospectively collected samples in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial, to examine associations of prostate cancer with androstenedione (4-A), testosterone (T), sex hormone-binding globulin (SHBG) and 3-androstanediol glucuronide (3-diolG). A total of 727 incident Caucasian prostate cancer cases (age 65 years, N = 396) and 889 matched controls were selected for this analysis. Overall, prostate cancer risks were unrelated to serum T, estimated free and bioavailable T, and SHBG; however, risks increased with increasing T:SHBG ratio (ptrend = 0.01), mostly related to risk in older men (65 years, ptrend = 0.001), particularly for aggressive disease [highest versus lowest quartile: odds ratio (OR) 2.76, 95% confidence interval (CI) 1.50-5.09]. No clear patterns were noted for 4-A and 3-diolG. In summary, our large prospective study did not show convincing evidence of a relationship between serum sex hormones and prostate cancer. T:SHBG ratio was related to risk in this older population of men, but the significance of this ratio in steroidal biology is unclear. JF - International Journal of Cancer AU - Weiss, Jocelyn M AU - Huang, Wen-Yi AU - Rinaldi, Sabina AU - Fears, Thomas R AU - Chatterjee, Nilanjan AU - Hsing, Ann W AU - Crawford, E David AU - Andriole, Gerald L AU - Kaaks, Rudolf AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, weissjoc@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2345 EP - 2350 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Toxicology Abstracts KW - Ovarian cancer KW - Androstenedione KW - Age KW - Apoptosis KW - Phospholipase C KW - Globulins KW - Steroid hormones KW - Sex hormones KW - Bioavailability KW - Differentiation KW - Testosterone KW - Prostate cancer KW - Carcinogenesis KW - steroid hormones KW - prostate cancer KW - Androgens KW - X 24310:Pharmaceuticals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20873358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Endogenous+sex+hormones+and+the+risk+of+prostate+cancer%3A+A+prospective+study&rft.au=Weiss%2C+Jocelyn+M%3BHuang%2C+Wen-Yi%3BRinaldi%2C+Sabina%3BFears%2C+Thomas+R%3BChatterjee%2C+Nilanjan%3BHsing%2C+Ann+W%3BCrawford%2C+E+David%3BAndriole%2C+Gerald+L%3BKaaks%2C+Rudolf%3BHayes%2C+Richard+B&rft.aulast=Weiss&rft.aufirst=Jocelyn&rft.date=2008-05-01&rft.volume=122&rft.issue=10&rft.spage=2345&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23326 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Androstenedione; Ovarian cancer; Differentiation; Testosterone; Apoptosis; Prostate cancer; Phospholipase C; Carcinogenesis; Globulins; Steroid hormones; Androgens; Sex hormones; Bioavailability; Age; steroid hormones; prostate cancer DO - http://dx.doi.org/10.1002/ijc.23326 ER - TY - JOUR T1 - Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China AN - 20873333; 8367569 AB - Biliary tract cancers, encompassing the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia. As part of a population-based case-control study conducted in Shanghai, China, we examined the associations of serum lipid levels with biliary stones and cancers. We included 460 biliary cancer cases (264 gallbladder, 141 extrahepatic bile duct, and 55 ampulla of Vater), 981 biliary stone cases and 858 healthy individuals randomly selected from the population. Participants completed an in-person interview and gave overnight fasting blood samples. Participants in the highest quintile of triglycerides (160 mg/dl) had a 1.4-fold risk of biliary stones (95% CI = 1.1-1.9), a 1.9-fold risk of gallbladder cancer (95% CI = 1.3-2.8), and a 4.8-fold risk of bile duct cancer (95% CI = 2.8-8.1), compared to the reference group (third quintile: 90-124 mg/dl). Participants in the lowest quintile of high-density lipoprotein (HDL) (<30 mg/dl) had a 4.2-fold risk of biliary stones (95% CI = 3.0-6.0), an 11.6-fold risk of gallbladder cancer (95% CI = 7.3-18.5), and a 16.8-fold risk of bile duct cancer (95% CI = 9.1-30.9), relative to the reference group (third quintile: 40-49 mg/dl). In addition, total cholesterol, low-density lipoprotein (LDL) and apolipoprotein A (apo A) were inversely associated with biliary stones; whereas low levels as well as high levels of total cholesterol, LDL, apo A and apolipoprotein B (apo B) were associated with excess risks of biliary tract cancers. Our findings support a role for serum lipids in gallstone development and biliary carcinogenesis. JF - International Journal of Cancer AU - Andreotti, Gabriella AU - Chen, Jinbo AU - Gao, Yu-Tang AU - Rashid, Asif AU - Chang, Shih-Chen AU - Shen, Ming-Chang AU - Wang, Bing-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Danforth, Kim N AU - Althuis, Michelle D AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, andreotg@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2322 EP - 2329 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Lipids KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - cholesterol KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20873333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Serum+lipid+levels+and+the+risk+of+biliary+tract+cancers+and+biliary+stones%3A+A+population-based+study+in+China&rft.au=Andreotti%2C+Gabriella%3BChen%2C+Jinbo%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BChang%2C+Shih-Chen%3BShen%2C+Ming-Chang%3BWang%2C+Bing-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BDanforth%2C+Kim+N%3BAlthuis%2C+Michelle+D%3BHsing%2C+Ann+W&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2008-05-01&rft.volume=122&rft.issue=10&rft.spage=2322&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23307 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Lipids; cholesterol; Cancer; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.23307 ER - TY - JOUR T1 - Fruit and vegetable intake and head and neck cancer risk in a large United States prospective cohort study AN - 20871999; 8367570 AB - Squamous head and neck cancers include cancers of the oral cavity, pharynx and larynx are the sixth leading cause of cancer mortality worldwide, resulting in more than 350,000 deaths annually. Intake of fruit and vegetables may protect against head and neck cancer incidence, although few prospective studies have examined this association. We investigated this relation in 490,802 United States participants of the NIH-AARP Diet and Health cohort using Cox proportional hazard models adjusted for potential confounders. During 2,193,751 person years of follow-up from 1995/1996-2000, 787 participants were diagnosed with head and neck cancer. We found an inverse association between total fruit and vegetable intake and head and neck cancer risk (per serving/day/1,000 calories, Hazard Ratio, 95% Confidence interval: 0.9,0.89-0.99). In models mutually adjusted for fruit and vegetable intake, the association was stronger for vegetables (fifth vs. first quintile: 0.6,0.50-0.85) than for fruits (fifth vs. first quintile: 0.8,0.68-1.11). When further subclassified into botanical groups, those in the highest tertile of leguminosae (dried beans, string beans and peas, 0.80, 0.67-0.96), rosaceae (apples, peach, nectarines, plums, pears and strawberries, 0.6,0.49-0.73), solanaceae (peppers and tomatoes, 0.8,0.69-0.98) and umbelliferae (carrots, 0.7,0.60-0.89) had decreased risk of head and neck cancer, but no significant associations were seen for 9 other botanical groups. Results from this large prospective observational study are consistent with previous case-control studies and support the hypothesis that total fruit and vegetable intake is associated with reduced risk of head and neck cancer. JF - International Journal of Cancer AU - Freedman, Neal D AU - Park, Yikyung AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Leitzmann, Michael F AU - Schatzkin, Arthur AU - Abnet, Christian C AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, freedmanne@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2330 EP - 2336 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Citrus KW - Solanaceae KW - Diets KW - Mortality KW - Rosaceae KW - fruits KW - Daucus KW - Fragaria KW - Cancer KW - Prunus KW - Lycopersicon esculentum KW - risk reduction KW - USA KW - Phaseolus vulgaris KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20871999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Fruit+and+vegetable+intake+and+head+and+neck+cancer+risk+in+a+large+United+States+prospective+cohort+study&rft.au=Freedman%2C+Neal+D%3BPark%2C+Yikyung%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2008-05-01&rft.volume=122&rft.issue=10&rft.spage=2330&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23319 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; risk reduction; Mortality; fruits; Cancer; Solanaceae; Lycopersicon esculentum; Citrus; Rosaceae; Phaseolus vulgaris; Daucus; Fragaria; Prunus; USA DO - http://dx.doi.org/10.1002/ijc.23319 ER - TY - JOUR T1 - [ super(18)F]FBEM-Z sub(HER2:342)-Affibody molecule-a new molecular tracer for in vivo monitoring of HER2 expression by positron emission tomography AN - 20871065; 8311306 AB - Purpose: The expression of human epidermal growth factor receptor-2 (HER2) receptors in cancers is correlated with a poor prognosis. If assessed in vivo, it could be used for selection of appropriate therapy for individual patients and for monitoring of the tumor response to targeted therapies. We have radiolabeled a HER2-binding Affibody molecule with fluorine-18 for in vivo monitoring of the HER2 expression by positron emission tomography (PET). Materials and methods: The HER2-binding Z sub(HER2:342)-Cys Affibody molecule was conjugated with N-2-(4-[ super(18)F]fluorobenzamido)ethyl]maleimide ([ super(18)F]FBEM). The in vitro binding of the resulting radioconjugate was characterized by receptor saturation and competition assays. For in vivo studies, the radioconjugate was injected into the tail vein of mice bearing subcutaneous HER2-positive or HER2-negative tumors. Some of the mice were pre-treated with non-labeled Z sub(HER2:342)-Cys. The animals were sacrificed at different times post-injection, and the radioactivity in selected tissues was measured. PET images were obtained using an animal PET scanner. Results: In vitro experiments indicated specific, high-affinity binding to HER2. PET imaging revealed a high accumulation of the radioactivity in the tumor as early as 20 min after injection, with a plateau being reached after 60 min. These results were confirmed by biodistribution studies demonstrating that, as early as 1 h post-injection, the tumor to blood concentration ratio was 7.5 and increased to 27 at 4 h. Pre-saturation of the receptors with unlabeled Z sub(HER2:342)-Cys lowered the accumulation of radioactivity in HER2-positive tumors to the levels observed in HER2-negative ones. Conclusion: Our results suggest that the [ super(18)F]FBEM-Z sub(HER2:342) radioconjugate can be used to assess HER2 expression in vivo. JF - European Journal of Nuclear Medicine and Molecular Imaging AU - Kramer-Marek, Gabriela AU - Kiesewetter, Dale O AU - Martiniova, Lucia AU - Jagoda, Elaine AU - Lee, Sang Bong AU - Capala, Jacek AD - National Institutes of Health, 10 Center Drive, Bldg. 10, Rm. 1B-37A, Bethesda, MD, 20892, USA, capalaj@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1008 EP - 1018 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 35 IS - 5 SN - 1619-7070, 1619-7070 KW - Biotechnology and Bioengineering Abstracts KW - Tracers KW - ErbB-2 protein KW - Veins KW - Positron emission tomography KW - Prognosis KW - Tumors KW - Radioactivity KW - Epidermal growth factor KW - Cancer KW - Blood levels KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20871065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.atitle=%5B+super%2818%29F%5DFBEM-Z+sub%28HER2%3A342%29-Affibody+molecule-a+new+molecular+tracer+for+in+vivo+monitoring+of+HER2+expression+by+positron+emission+tomography&rft.au=Kramer-Marek%2C+Gabriela%3BKiesewetter%2C+Dale+O%3BMartiniova%2C+Lucia%3BJagoda%2C+Elaine%3BLee%2C+Sang+Bong%3BCapala%2C+Jacek&rft.aulast=Kramer-Marek&rft.aufirst=Gabriela&rft.date=2008-05-01&rft.volume=35&rft.issue=5&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Nuclear+Medicine+and+Molecular+Imaging&rft.issn=16197070&rft_id=info:doi/10.1007%2Fs00259-007-0658-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tracers; Veins; ErbB-2 protein; Prognosis; Positron emission tomography; Radioactivity; Tumors; Epidermal growth factor; Cancer; Blood levels DO - http://dx.doi.org/10.1007/s00259-007-0658-0 ER - TY - JOUR T1 - Quantitation of HER2 and telomerase biomarkers in solid tumors with IgY antibodies and nanocrystal detection AN - 20856960; 8367551 AB - In an effort to improve affinity biomarker validation in fixed patient tissue specimens, we have developed a novel quantum dot-based bioimaging system that utilizes chicken IgY antibody for high sensitivity and specificity relative quantitation of cancer proteins. Monospecific, polyclonal IgYs were generated against human HER2 and telomerase, and analytically validated for specificity by western blot and immunohistochemistry on tumor and normal cells and for relative affinity by layered peptide array (LPA). IgYs bound desired targets in cell lines and fixed tissues and showed greater affinity than commercial mammalian antibodies for both HER2 and telomerase proteins. In tissue microarray experiments, HER2 quantitation with IgY antibody and quantum dot imaging correlated well with chromogenic in situ hybridization (CISH), whereas telomerase quantitation suggested a trend toward correlation with prostate cancer Gleason Grade and differentiation. Although patient numbers were small, these findings demonstrate the feasibility of relative quantitation of cancer biomarkers with IgY and quantum dot fluorophores, and show promise for rigorous clinical validation in large patient cohorts. JF - International Journal of Cancer AU - Xiao, Yan AU - Gao, Xiugong AU - Gannot, Gallya AU - Emmert-Buck, Michael R AU - Srivastava, Sudhir AU - Wagner, Paul D AU - Amos, Michael D AU - Barker, Peter E AD - NIST-NCI EDRN Cancer Biomarker Reference Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, yan.xiao@nist.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2178 EP - 2186 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 10 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Western blotting KW - ErbB-2 protein KW - Solid tumors KW - Telomerase KW - fluorophores KW - Tumors KW - imaging KW - biomarkers KW - Differentiation KW - Antibodies KW - Prostate cancer KW - Immunohistochemistry KW - Quantitation KW - W 30910:Imaging KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Quantitation+of+HER2+and+telomerase+biomarkers+in+solid+tumors+with+IgY+antibodies+and+nanocrystal+detection&rft.au=Xiao%2C+Yan%3BGao%2C+Xiugong%3BGannot%2C+Gallya%3BEmmert-Buck%2C+Michael+R%3BSrivastava%2C+Sudhir%3BWagner%2C+Paul+D%3BAmos%2C+Michael+D%3BBarker%2C+Peter+E&rft.aulast=Xiao&rft.aufirst=Yan&rft.date=2008-05-01&rft.volume=122&rft.issue=10&rft.spage=2178&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Western blotting; ErbB-2 protein; Telomerase; Solid tumors; Tumors; fluorophores; biomarkers; imaging; Differentiation; Antibodies; Prostate cancer; Quantitation; Immunohistochemistry DO - http://dx.doi.org/10.1002/ijc.23320 ER - TY - JOUR T1 - Recent progress in antiretrovirals - lessons from resistance AN - 20854067; 8342031 AB - Recent failures in efforts to develop an effective vaccine against HIV-1 infection have emphasized the importance of antiretroviral therapy in treating HIV-1-infected patients. Thus far, inhibitors of two viral enzymes, reverse transcriptase and protease, have had a profoundly positive impact on the survival of HIV-1-infected patients. However, new inhibitors that act at diverse steps in the viral replication cycle are urgently needed because of the development of resistance to currently available antiretrovirals. This review summarizes recent progress in antiretroviral drug discovery and development by specifically focusing on novel inhibitors of three phases of replication: viral entry, integration of the viral DNA into the host cell genome and virus particle maturation. JF - Drug Discovery Today AU - Adamson, C S AU - Freed, E O AD - HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702-1201, United States, efreed@nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 424 EP - 432 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 13 IS - 9-10 SN - 1359-6446, 1359-6446 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Genomes KW - Replication KW - antiretroviral therapy KW - Survival KW - Enzymes KW - Infection KW - Drug discovery KW - Integration KW - Human immunodeficiency virus 1 KW - DNA KW - RNA-directed DNA polymerase KW - Proteinase KW - Vaccines KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20854067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Recent+progress+in+antiretrovirals+-+lessons+from+resistance&rft.au=Adamson%2C+C+S%3BFreed%2C+E+O&rft.aulast=Adamson&rft.aufirst=C&rft.date=2008-05-01&rft.volume=13&rft.issue=9-10&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2008.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Integration; Drug discovery; Replication; antiretroviral therapy; DNA; RNA-directed DNA polymerase; Enzymes; Survival; Proteinase; Vaccines; Infection; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.drudis.2008.02.003 ER - TY - JOUR T1 - Cell-Free Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death: A Meta-analysis AN - 20851933; 8302081 AB - CONTEXT: Hemoglobin-based blood substitutes (HBBSs) are infusible oxygen-carrying liquids that have long shelf lives, have no need for refrigeration or cross-matching, and are ideal for treating hemorrhagic shock in remote settings. Some trials of HBBSs during the last decade have reported increased risks without clinical benefit. OBJECTIVE: To assess the safety of HBBSs in surgical, stroke, and trauma patients. DATA SOURCES: PubMed, EMBASE, and Cochrane Library searches for articles using hemoglobin and blood substitutes from 1980 through March 25, 2008; reviews of Food and Drug Administration (FDA) advisory committee meeting materials; and Internet searches for company press releases. STUDY SELECTION: Randomized controlled trials including patients aged 19 years and older receiving HBBSs therapeutically. The database searches yielded 70 trials of which 13 met these criteria; in addition, data from 2 other trials were reported in 2 press releases, and additional data were included in 1 relevant FDA review. DATA EXTRACTION: Data on death and myocardial infarction (MI) as outcome variables. RESULTS: Sixteen trials involving 5 different products and 3711 patients in varied patient populations were identified. A test for heterogeneity of the results of these trials was not significant for either mortality or MI (for both, I super(2) = 0%, P greater than or equal to .60), and data were combined using a fixed-effects model. Overall, there was a statistically significant increase in the risk of death (164 deaths in the HBBS-treated groups and 123 deaths in the control groups; relative risk [RR], 1.30; 95% confidence interval [CI], 1.05-1.61) and risk of MI (59 MIs in the HBBS-treated groups and 16 MIs in the control groups; RR, 2.71; 95% CI, 1.67-4.40) with these HBBSs. Subgroup analysis of these trials indicated the increased risk was not restricted to a particular HBBS or clinical indication. CONCLUSION: Based on the available data, use of HBBSs is associated with a significantly increased risk of death and MI. Published online April 28, 2008 (doi:10.1001/jama.299.19.jrv80007). JF - JAMA: Journal of the American Medical Association AU - Natanson, Charles AU - Kern, Steven J AU - Lurie, Peter AU - Banks, Steven M AU - Wolfe, Sidney M AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland (Drs Natanson and Banks and Mr Kern) Deceased Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2304 EP - 2312 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 299 IS - 19 SN - 0098-7484, 0098-7484 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Blood KW - stroke KW - myocardial infarction KW - Reviews KW - advisory committees KW - FDA KW - clinical trials KW - Drugs KW - Internet KW - H 13000:Medical Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20851933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Cell-Free+Hemoglobin-Based+Blood+Substitutes+and+Risk+of+Myocardial+Infarction+and+Death%3A+A+Meta-analysis&rft.au=Natanson%2C+Charles%3BKern%2C+Steven+J%3BLurie%2C+Peter%3BBanks%2C+Steven+M%3BWolfe%2C+Sidney+M&rft.aulast=Natanson&rft.aufirst=Charles&rft.date=2008-05-01&rft.volume=299&rft.issue=19&rft.spage=2304&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - stroke; Blood; Mortality; myocardial infarction; Reviews; advisory committees; FDA; clinical trials; Drugs; Internet ER - TY - JOUR T1 - Past body mass index and risk of mortality among women AN - 20784995; 8307023 AB - Background: Epidemiologic studies of body mass index (BMI) in relation to mortality commonly exclude persons with health conditions and/or a history of smoking to prevent bias resulting from illness-related weight loss ('reverse causation'). Analysis of BMI from an earlier time period may minimize reverse causation without requiring exclusion of participants based on disease or smoking history. Methods: We prospectively examined BMI based on technician measurements of weight and height from 10 years prior to start of follow-up in relation to subsequent mortality in a cohort of 50 186 women who were 40-93 years old at baseline in 1987-1989. Deaths were ascertained through the US National Death Index. Proportional hazards regression was used to estimate hazard ratios (HRs) of mortality, adjusted for age, education, race/ethnicity, income, menopausal hormone use, smoking and physical activity. Results: During 10 years of follow-up through 1997, 5201 women died. Overall, we observed a J-shaped association between BMI and mortality, with increased risk for women who were underweight, overweight or obese. The HRs and 95% confidence intervals of mortality for BMI categories of <18.5, 18.5-20.9, 21.0-23.4 (reference), 23.5-24.9, 25.0-27.4, 27.5-29.9, 30.0-34.9 and 35.0 + kg m@@u-2@ were 1.43 (1.19, 1.72), 1.07 (0.98, 1.17), 1.00 (reference), 1.10 (1.00, 1.20), 1.20 (1.11, 1.31), 1.23 (1.11, 1.37), 1.60 (1.44, 1.77) and 1.92 (1.64, 2.24). There was little evidence that pre-existing conditions (heart disease, diabetes and/or cancer) or smoking history modified the past BMI and mortality relation (@iP=0.54 and 0.76). Conclusions: In this large cohort of women, BMI based on technician measurements of weight and height from 10 years prior to baseline showed increased risk for mortality across the range of overweight and obesity, regardless of disease and smoking history. Observed associations between overweight, obesity and mortality in healthy individuals may also apply to persons with a history of disease or smoking. JF - International Journal of Obesity AU - Moore, S C AU - Mayne, ST AU - Graubard, B I AU - Schatzkin, A AU - Albanes, D AU - Schairer, C AU - Hoover, R N AU - Leitzmann, M F AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS South, Room 3033, 6120 Executive Boulevard, Bethesda, MD 20892, USA, moorest@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 730 EP - 739 VL - 32 IS - 5 SN - 0307-0565, 0307-0565 KW - Risk Abstracts; Physical Education Index KW - Historical account KW - Death KW - Body mass KW - Women KW - obesity KW - Health KW - Hormones KW - heart diseases KW - Smoking KW - diabetes mellitus KW - Weight KW - body mass KW - income KW - Diseases KW - Ethnic groups KW - Mortality KW - Obesity KW - Cancer KW - Education KW - Females KW - technicians KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20784995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Past+body+mass+index+and+risk+of+mortality+among+women&rft.au=Moore%2C+S+C%3BMayne%2C+ST%3BGraubard%2C+B+I%3BSchatzkin%2C+A%3BAlbanes%2C+D%3BSchairer%2C+C%3BHoover%2C+R+N%3BLeitzmann%2C+M+F&rft.aulast=Moore&rft.aufirst=S&rft.date=2008-05-01&rft.volume=32&rft.issue=5&rft.spage=730&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fsj.ijo.0803801 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Death; Body mass; Obesity; Smoking; Women; Diseases; Weight; Health; Mortality; Historical account; obesity; Cancer; body mass; technicians; heart diseases; Education; Hormones; Ethnic groups; Females; diabetes mellitus; income DO - http://dx.doi.org/10.1038/sj.ijo.0803801 ER - TY - JOUR T1 - Introduction to AAV Vector special issue AN - 20714173; 8220448 JF - Gene Therapy AU - Nirenberg, M Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 807 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 11 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene therapy KW - Adeno-associated virus KW - W 30905:Medical Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20714173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Introduction+to+AAV+Vector+special+issue&rft.au=Nirenberg%2C+M&rft.aulast=Nirenberg&rft.aufirst=M&rft.date=2008-05-01&rft.volume=15&rft.issue=11&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2008.62 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene therapy; Adeno-associated virus DO - http://dx.doi.org/10.1038/gt.2008.62 ER - TY - JOUR T1 - Occupation and bladder cancer in a hospital-based case-control study in Spain AN - 20690770; 8202611 AB - OBJECTIVES: We investigated the association between occupation and bladder cancer in a hospital-based case-control study conducted in Spain. METHODS: 1219 patients with transitional cell carcinoma of the urinary bladder and 1271 controls selected from 18 hospitals in Spain between June 1998 and September 2000 provided detailed information on life-time occupational history, smoking habits, medical history, and other factors. We used unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI) for each occupation and industry, adjusting for age, hospital region, smoking duration, and employment in a high-risk occupation for bladder cancer. RESULTS: Statistically significant increased risks were observed among men employed as machine operators in the printing industry (OR 5.4; 95% CI 1.6 to 17.7), among men employed in the transportation equipment industry (OR 1.6; 95% CI 1.1 to 2.6) and among those who had worked for greater than or equal to 10 years in the electrical/gas/sanitary services (OR 3.9; 95% CI 1.5 to 10.4) and in hotels and other lodgings (OR 3.1; 95% CI 1.3 to 7.3). Men who worked as miscellaneous mechanics and repairers (OR 2.0; 95% CI 1.1 to 3.6) and as supervisors in production occupations (OR 2.1; 95% CI 1.2 to 3.6) also had excess risks for bladder cancer. Male farmers and those who worked in crop and livestock production had decreased risks for bladder cancer. We found no significant associations between occupation or industry and bladder cancer risk among women. CONCLUSIONS: We did not observe excess bladder cancer risk for many of the occupations identified as being a priori at high risk. Examination of more detailed job exposure information should help clarify these associations. JF - Occupational and Environmental Medicine AU - Samanic, C M AU - Kogevinas, M AU - Silverman, D T AU - Tardon, A AU - Serra, C AU - Malats, N AU - Real, F X AU - Carrato, A AU - Garcia-Closas, R AU - Sala, M AU - Lloreta, J AU - Rothman, N AU - Dosemeci, M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 347 EP - 353 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Age KW - Spain KW - Printing industry KW - Crops KW - Cancer KW - hotels KW - Livestock KW - Smoking KW - urinary bladder KW - Transportation KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20690770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupation+and+bladder+cancer+in+a+hospital-based+case-control+study+in+Spain&rft.au=Samanic%2C+C+M%3BKogevinas%2C+M%3BSilverman%2C+D+T%3BTardon%2C+A%3BSerra%2C+C%3BMalats%2C+N%3BReal%2C+F+X%3BCarrato%2C+A%3BGarcia-Closas%2C+R%3BSala%2C+M%3BLloreta%2C+J%3BRothman%2C+N%3BDosemeci%2C+M&rft.aulast=Samanic&rft.aufirst=C&rft.date=2008-05-01&rft.volume=65&rft.issue=5&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - urinary bladder; Smoking; Historical account; Age; Transportation; Printing industry; Cancer; Crops; Occupational exposure; Livestock; hotels; Spain ER - TY - JOUR T1 - Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders AN - 20690440; 8193996 AB - Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide. To date, the monoaminergic systems (serotonergic, noradrenergic and dopaminergic) in the brain have received the greatest attention in neurobiological studies of mood disorders, and most therapeutics target these systems. However, there is growing evidence that the glutamatergic system is central to the neurobiology and treatment of these disorders. Here, we review data supporting the involvement of the glutamatergic system in mood-disorder pathophysiology as well as the efficacy of glutamatergic agents in mood disorders. We also discuss exciting new prospects for the development of improved therapeutics for these devastating disorders. JF - Nature Reviews: Drug Discovery AU - Sanacora, Gerard AU - Zarate, Carlos A AU - Krystal, John H AU - Manji, Husseini K AD - Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA., manjih@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 426 EP - 437 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 7 IS - 5 SN - 1474-1784, 1474-1784 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Mood KW - Glutamatergic transmission KW - Mental disorders KW - Dopamine KW - Norepinephrine KW - Brain KW - Drug development KW - Attention KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20690440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Targeting+the+glutamatergic+system+to+develop+novel%2C+improved+therapeutics+for+mood+disorders&rft.au=Sanacora%2C+Gerard%3BZarate%2C+Carlos+A%3BKrystal%2C+John+H%3BManji%2C+Husseini+K&rft.aulast=Sanacora&rft.aufirst=Gerard&rft.date=2008-05-01&rft.volume=7&rft.issue=5&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741784&rft_id=info:doi/10.1038%2Fnrd2462 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mood; Mental disorders; Glutamatergic transmission; Dopamine; Norepinephrine; Brain; Drug development; Attention DO - http://dx.doi.org/10.1038/nrd2462 ER - TY - JOUR T1 - Respiratory Toxicity of Diacetyl in C57Bl/6 Mice AN - 20675828; 8204073 AB - Diacetyl, a component of artificial butter flavoring, is a potential etiological agent of obliterative bronchiolitis (OB); however, the toxic dose and mechanisms of toxicity remain controversial. We evaluated the respiratory toxicity of diacetyl in a murine model using several exposure profiles relevant to workplace conditions at microwave popcorn packaging plants. Male C57Bl/6 mice were exposed to inhaled diacetyl across several concentrations and duration profiles, or by direct oropharyngeal aspiration. Effects of diacetyl on the respiratory tract were evaluated by histopathology and BALF analyses. Subacute exposure to 200 or 400 ppm diacetyl for 5 days caused deaths, necrotizing rhinitis, necrotizing laryngitis and bronchitis. Reducing the exposure to 1 h/day (100, 200, 400 ppm) for 4 weeks resulted in less nasal and laryngeal toxicity, but led to peribronchial and peribronchiolar lymphocytic inflammation. A similar pattern was observed with intermittent high-dose exposures at 1200 ppm (15 min, twice a day, 4 weeks). Subchronic exposures to 100 ppm (6 h/day, 12 weeks) caused moderate nasal injury, and peribronchial lymphocytic inflammation accompanied by epithelial atrophy, denudation, and regeneration. Treatment with 400 mg/kg by oropharyngeal aspiration to bypass the nose caused foci of fibrohistiocytic proliferation with little or no inflammation at the junction of the terminal bronchiole and alveolar duct. Depending on the route and duration of exposure, diacetyl causes significant epithelial injury, peribronchial lymphocytic inflammation, or fibrohistiocytic lesions in the terminal bronchioles. Collectively these results indicate that clinically relevant diacetyl exposures result in a pattern of injury that replicates features of human OB. JF - Toxicological Sciences AU - Morgan, Daniel L AU - Flake, Gordon P AU - Kirby, Patrick J AU - Palmer, Scott M AD - Respiratory Toxicology, Laboratory of Molecular Toxicology, National Toxicology Program/National Institute of Environmental Health Sciences. Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 169 EP - 180 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Injuries KW - Animal models KW - Flavorings KW - Rhinitis KW - Toxicity KW - Alveoli KW - Diacetyl KW - obliterative bronchiolitis KW - Inflammation KW - Butter KW - Bronchitis KW - Laryngitis KW - Nose KW - Atrophy KW - Respiratory tract KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20675828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Respiratory+Toxicity+of+Diacetyl+in+C57Bl%2F6+Mice&rft.au=Morgan%2C+Daniel+L%3BFlake%2C+Gordon+P%3BKirby%2C+Patrick+J%3BPalmer%2C+Scott+M&rft.aulast=Morgan&rft.aufirst=Daniel&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Injuries; Animal models; Flavorings; Rhinitis; Toxicity; Diacetyl; Alveoli; Inflammation; obliterative bronchiolitis; Butter; Atrophy; Nose; Laryngitis; Bronchitis; Respiratory tract ER - TY - JOUR T1 - Estimating Consumer Familiarity with Health Terminology: A Context-based Approach AN - 20673332; 8199215 AB - OBJECTIVES: Effective health communication is often hindered by a "vocabulary gap" between language familiar to consumers and jargon used in medical practice and research. To present health information to consumers in a comprehensible fashion, we need to develop a mechanism to quantify health terms as being more likely or less likely to be understood by typical members of the lay public. Prior research has used approaches including syllable count, easy word list, and frequency count, all of which have significant limitations. DESIGN: In this article, we present a new method that predicts consumer familiarity using contextual information. The method was applied to a large query log data set and validated using results from two previously conducted consumer surveys. MEASUREMENTS: We measured the correlation between the survey result and the context-based prediction, syllable count, frequency count, and log normalized frequency count. RESULTS: The correlation coefficient between the context-based prediction and the survey result was 0.773 (p < 0.001), which was higher than the correlation coefficients between the survey result and the syllable count, frequency count, and log normalized frequency count (p less than or equal to 0.012). CONCLUSIONS: The context-based approach provides a good alternative to the existing term familiarity assessment methods. JF - Journal of the American Medical Informatics Association AU - Zeng-Treitler, Qing AU - Goryachev, Sergey AU - Tse, Tony AU - Keselman, Alla AU - Boxwala, Aziz AD - Decision Systems Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Bethesda, MD. Aquilent, Inc., Laurel, MD Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 349 EP - 356 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 3 SN - 1067-5027, 1067-5027 KW - Biotechnology Research Abstracts (through 1992) KW - Communication KW - Language KW - Consumers KW - Familiarity KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20673332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Estimating+Consumer+Familiarity+with+Health+Terminology%3A+A+Context-based+Approach&rft.au=Zeng-Treitler%2C+Qing%3BGoryachev%2C+Sergey%3BTse%2C+Tony%3BKeselman%2C+Alla%3BBoxwala%2C+Aziz&rft.aulast=Zeng-Treitler&rft.aufirst=Qing&rft.date=2008-05-01&rft.volume=15&rft.issue=3&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Consumers; Familiarity; Language; Communication ER - TY - JOUR T1 - Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice AN - 20668370; 8193986 AB - Protocols for preparing and culturing primary keratinocytes from newborn and adult mouse epidermis have evolved over the past 35 years. This protocol is now routinely applied to mice of various genetic backgrounds for in vitro studies of signaling pathways in differentiation and cell transformation, and for assessing the in vivo phenotype of altered keratinocytes in grafts of cells on immunodeficient mice. Crucial in the development and application of the procedure was the observation that keratinocytes proliferate in media of low calcium concentration, but rapidly commit to differentiation at calcium concentrations >0.07 mM after the initial attachment period. Preparing primary keratinocytes from ten newborn mice requires 2-3 h of hands-on time. Related procedures are also provided: preparing immature hair follicle buds, developing dermal hair follicles and fibroblasts from newborn mice, preparing primary keratinocytes from adult mice and grafting cell mixtures on athymic nude mice. JF - Nature Protocols AU - Lichti, Ulrike AU - Anders, Joanna AU - Yuspa, Stuart H Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 799 EP - 810 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 5 SN - 1754-2189, 1754-2189 KW - Biotechnology Research Abstracts (through 1992) KW - Transformation KW - Calcium KW - Skin KW - Grafting KW - Follicles KW - Immunodeficiency KW - Cell culture KW - Hair KW - Buds KW - Fibroblasts KW - Epidermis KW - Differentiation KW - Neonates KW - Keratinocytes KW - Media (culture) KW - Signal transduction KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20668370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Isolation+and+short-term+culture+of+primary+keratinocytes%2C+hair+follicle+populations+and+dermal+cells+from+newborn+mice+and+keratinocytes+from+adult+mice+for+in+vitro+analysis+and+for+grafting+to+immunodeficient+mice&rft.au=Lichti%2C+Ulrike%3BAnders%2C+Joanna%3BYuspa%2C+Stuart+H&rft.aulast=Lichti&rft.aufirst=Ulrike&rft.date=2008-05-01&rft.volume=3&rft.issue=5&rft.spage=799&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.50 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Keratinocytes; Neonates; Follicles; Hair; Immunodeficiency; Skin; Calcium; Differentiation; Grafting; Fibroblasts; Buds; Signal transduction; Transformation; Cell culture; Media (culture); Epidermis DO - http://dx.doi.org/10.1038/nprot.2008.50 ER - TY - JOUR T1 - Risk of Leukemia Among Survivors of Testicular Cancer: A Population-based Study of 42,722 Patients AN - 20562788; 9272771 AB - Purpose The aim of this study is to quantify excess absolute risk (EAR) and excess relative risk (ERR) of secondary leukemia among a large population-based group of testicular cancer survivors. Methods We identified 42,722 1-year survivors of testicular cancer within 14 population-based cancer registries in Europe and North America (1943-2002). Poisson regression analysis was used to model EAR (per 100,000 person-years [PY]) and ERR of secondary leukemia. Cumulative risks were calculated using a competing risk model. Results Secondary leukemia developed in 89 patients (EAR = 10.8 per 100,000 PY, 95% confidence interval [CI] = 7.6-14.6; ERR = 1.6, 95%CI = 1.0-2.2). Statistically significantly elevated risks were observed for acute myeloid leukemia (AML) (EAR = 7.2, 95%CI = 4.7-10.2) and acute lymphoblastic leukemia (EAR = 1.3, 95%CI = 0.4-2.8). In multivariate analyses, AML risk was higher among patients whose initial management included chemotherapy compared to those receiving radiotherapy alone (p = 0.1). Excess cumulative leukemia risk was approximately 0.23% by 30 years after testicular cancer diagnosis. Conclusions Although ERR of leukemia following testicular cancer is large, EAR and cumulative risk, which are better gauges of the population burden, are small. JF - Annals of Epidemiology AU - Howard, Regan AU - Gilbert, Ethel AU - Lynch, Charles F AU - Hall, Per AU - Storm, Hans AU - Holowaty, Eric AU - Pukkala, Eero AU - Langmark, Froydis AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fossa, Sophie D AU - Allan, James M AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics; National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD, reganho@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 416 EP - 421 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 5 SN - 1047-2797, 1047-2797 KW - Risk Abstracts; Immunology Abstracts KW - Testicular Neoplasms KW - Leukemia KW - Second Primary Neoplasms KW - Cohort Studies KW - Risk assessment KW - Testes KW - North America KW - Acute myeloid leukemia KW - Chemotherapy KW - Radiotherapy KW - Population studies KW - Europe KW - Ear KW - radiotherapy KW - chemotherapy KW - Cancer KW - Models KW - Multivariate analysis KW - Acute lymphatic leukemia KW - Risk factors KW - Regression analysis KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20562788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Risk+of+Leukemia+Among+Survivors+of+Testicular+Cancer%3A+A+Population-based+Study+of+42%2C722+Patients&rft.au=Howard%2C+Regan%3BGilbert%2C+Ethel%3BLynch%2C+Charles+F%3BHall%2C+Per%3BStorm%2C+Hans%3BHolowaty%2C+Eric%3BPukkala%2C+Eero%3BLangmark%2C+Froydis%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFossa%2C+Sophie+D%3BAllan%2C+James+M%3BTravis%2C+Lois+B&rft.aulast=Howard&rft.aufirst=Regan&rft.date=2008-05-01&rft.volume=18&rft.issue=5&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2008.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Testes; Risk assessment; Acute myeloid leukemia; Chemotherapy; Population studies; Radiotherapy; Ear; Cancer; Models; Multivariate analysis; Risk factors; Acute lymphatic leukemia; Regression analysis; Leukemia; radiotherapy; chemotherapy; North America; Europe DO - http://dx.doi.org/10.1016/j.annepidem.2008.01.003 ER - TY - JOUR T1 - Obesity following kidney transplantation and steroid avoidance immunosuppression AN - 20437170; 9125781 AB - Elster EA, Leeser DB, Morrissette C, Pepek JM, Quiko A, Hale DA, Chamberlain C, Salaita C, Kirk AD, Mannon RB. Obesity following kidney transplantation and steroid avoidance immunosuppression.Clin Transplant 2008: 22: 354-359. [copy 2008 Blackwell MunksgaardAbstract:Obesity is an important co-morbidity within end-stage renal disease (ESRD) and renal transplant populations. Previous studies have suggested that chronic corticosteroids result in increased body weight post-transplant. With the recent adoption of steroid-sparing immunosuppressive strategies, we evaluated the effect of these strategies on body mass index (BMI) after renal transplantation. We examined 95 renal transplant recipients enrolled in National Institutes of Health clinical transplant trials over the past three yr who received either lymphocyte depletion-based steroid sparing or traditional immunosuppressive therapy that included steroids for maintenance immunosuppression. Recipients were overweight prior to transplant and no significant differences existed in pre-transplant BMI among treatment groups. Regardless of therapy, BMI increased post-transplant in all recipients. The BMI increase consisted of an average weight gain of 5.01 plus or minus 7.12kg (mean, SD) post-transplant. Additionally, in a number of recipients placed on maintenance steroids, subsequent withdrawal at a mean of 100d post-transplant had no impact on weight gain. Thus, body weight and BMI increase following kidney transplantation, even in the absence of steroids. Thus, patients gain weight after renal transplantation regardless of the treatment strategy. Steroid avoidance alone does not reduce risk factors associated with obesity in our patient population. JF - Clinical Transplantation AU - Elster, Eric A AU - Leeser, David B AU - Morrissette, Craig AU - Pepek, Joseph M AU - Quiko, Albin AU - Hale, Douglas A AU - Chamberlain, Christine AU - Salaita, Christine AU - Kirk, Allan D AU - Mannon, Roslyn B AD - aTransplantation Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, eric.elster@med.navy.mil Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 354 EP - 359 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 22 IS - 3 SN - 0902-0063, 0902-0063 KW - Physical Education Index; Immunology Abstracts KW - end-stage renal disease KW - immunosuppression KW - kidney transplantation KW - obesity KW - steroid avoidance KW - Kidney transplantation KW - Body mass KW - Retinoblastoma protein KW - Adoption KW - Lymphocytes KW - Clinical trials KW - Immunosuppressive agents KW - Dopamine KW - Body weight KW - Weight KW - Risk factors KW - Organ transplants KW - Steroids KW - Obesity KW - Strategy KW - Kidney diseases KW - Therapy KW - Patients KW - Steroid hormones KW - Kidneys KW - Corticoids KW - Body mass index KW - Immunosuppression KW - End-stage renal disease KW - F 06955:Immunomodulation & Immunopharmacology KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20437170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Transplantation&rft.atitle=Obesity+following+kidney+transplantation+and+steroid+avoidance+immunosuppression&rft.au=Elster%2C+Eric+A%3BLeeser%2C+David+B%3BMorrissette%2C+Craig%3BPepek%2C+Joseph+M%3BQuiko%2C+Albin%3BHale%2C+Douglas+A%3BChamberlain%2C+Christine%3BSalaita%2C+Christine%3BKirk%2C+Allan+D%3BMannon%2C+Roslyn+B&rft.aulast=Elster&rft.aufirst=Eric&rft.date=2008-05-01&rft.volume=22&rft.issue=3&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Clinical+Transplantation&rft.issn=09020063&rft_id=info:doi/10.1111%2Fj.1399-0012.2008.00792.x LA - English DB - Physical Education Index N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Weight; Body mass; Strategy; Therapy; Organ transplants; Patients; Kidneys; Steroids; Kidney transplantation; Retinoblastoma protein; Kidney diseases; Adoption; Steroid hormones; Lymphocytes; Immunosuppressive agents; Clinical trials; Corticoids; Dopamine; Body weight; Risk factors; Body mass index; End-stage renal disease; Immunosuppression DO - http://dx.doi.org/10.1111/j.1399-0012.2008.00792.x ER - TY - JOUR T1 - The adolescent brain: Insights from functional neuroimaging research AN - 20266206; 8903572 AB - With the development of functional neuroimaging tools, the past two decades have witnessed an explosion of work examining functional brain maps, mostly in the adult brain. Against this backdrop of work in adults, developmental research begins to gather a substantial body of knowledge about brain maturation. The purpose of this review is to present some of these findings from the perspective of functional neuroimaging. First, a brief survey of available neuroimaging techniques (i.e., fMRI, MRS, MEG, PET, SPECT, and infrared techniques) is provided. Next, the key cognitive, emotional, and social changes taking place during adolescence are outlined. The third section gives examples of how these behavioral changes can be understood from a neuroscience perspective. The conclusion places this functional neuroimaging research in relation to clinical and molecular work, and shows how answers will ultimately come from the combined efforts of these disciplines. JF - Developmental Neurobiology AU - Ernst, Monique AU - Mueller, Sven C AD - Emotional Development and Affective Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, ernstm@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 729 EP - 743 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 68 IS - 6 SN - 1932-8451, 1932-8451 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Emotions KW - Magnetoencephalography KW - Neuroimaging KW - Nervous system KW - Cognitive ability KW - Adolescence KW - Reviews KW - Functional magnetic resonance imaging KW - Positron emission tomography KW - Single photon emission computed tomography KW - N3 11003:Developmental neuroscience KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20266206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Neurobiology&rft.atitle=The+adolescent+brain%3A+Insights+from+functional+neuroimaging+research&rft.au=Ernst%2C+Monique%3BMueller%2C+Sven+C&rft.aulast=Ernst&rft.aufirst=Monique&rft.date=2008-05-01&rft.volume=68&rft.issue=6&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Developmental+Neurobiology&rft.issn=19328451&rft_id=info:doi/10.1002%2Fdneu.20615 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Magnetoencephalography; Emotions; Brain mapping; Nervous system; Neuroimaging; Cognitive ability; Functional magnetic resonance imaging; Reviews; Adolescence; Positron emission tomography; Single photon emission computed tomography DO - http://dx.doi.org/10.1002/dneu.20615 ER - TY - JOUR T1 - Addition of CpG ODN to recombinant Pseudomonas aeruginosa ExoProtein A conjugates of AMA1 and Pfs25 greatly increases the number of responders AN - 20047440; 8554546 AB - Both the blood-stage protein apical membrane antigen 1 (AMA1) and the 25- kDa sexual-stage protein (Pfs25) of Plasmodium falciparum are two leading candidates in malarial vaccine development. We have previously demonstrated that conjugation of these malarial antigens to recombinant Pseudomonas aeruginosa ExoProtein A (rEPA) significantly increased the mean-specific functional antibody responses in mice; however, some mice responded poorly and were unable to demonstrate a functional response. We hypothesized that the immunogenicities of these two malarial antigens could be further enhanced by the inclusion of a CpG oligodeoxynucleotide in the formulation. Mice were immunized with either rEPA-conjugated or unconjugated AMA1 and Pfs25 formulated on Alhydrogel with or without the addition of CPG 7909. Mice received the formulations on days 0 and 28, and mouse sera were collected on day 42. ELISA analyses on these sera showed that the addition of CPG 7909 to AMA1-rEPA and Pfs25-rEPA formulated on Alhydrogel induced significantly higher mean antibody titers than the formulations without CPG 7909, and led to a mixed Th1/Th2 response as demonstrated by the production of mouse IgG1 and IgG2a subclasses. The presence of CPG 7909 in the formulations of both conjugated antigens greatly increased the proportion of responders with antibody titers sufficient to inhibit blood-stage parasite growth in vitro or block transmission of sexual-stage parasites to mosquitoes. The results obtained in this study indicate the potential use of a combination strategy to increase the number of responders to malarial antigens in humans. JF - Vaccine AU - Qian, Feng AU - Rausch, Kelly M AU - Muratova, Olga AU - Zhou, Hong AU - Song, Guanhong AU - Diouf, Ababacar AU - Lambert, Lynn AU - Narum, David L AU - Wu, Yimin AU - Saul, Allan AU - Miller, Louis H AU - Long, Carole A AU - Mullen, Gregory ED AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA, greg.mullen@kcl.ac.uk Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2521 EP - 2527 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 20 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Malaria KW - AMA1 KW - Pfs25 KW - Conjugation KW - CPG 7909 KW - rEPA KW - Vaccine KW - Apical membrane antigen 1 KW - Parasites KW - Enzyme-linked immunosorbent assay KW - Helper cells KW - Plasmodium falciparum KW - CpG islands KW - Membrane proteins KW - Oligonucleotides KW - Antibodies KW - Immunogenicity KW - Immunoglobulin G KW - Lymphocytes T KW - Vaccines KW - Pseudomonas aeruginosa KW - K 03350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20047440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Addition+of+CpG+ODN+to+recombinant+Pseudomonas+aeruginosa+ExoProtein+A+conjugates+of+AMA1+and+Pfs25+greatly+increases+the+number+of+responders&rft.au=Qian%2C+Feng%3BRausch%2C+Kelly+M%3BMuratova%2C+Olga%3BZhou%2C+Hong%3BSong%2C+Guanhong%3BDiouf%2C+Ababacar%3BLambert%2C+Lynn%3BNarum%2C+David+L%3BWu%2C+Yimin%3BSaul%2C+Allan%3BMiller%2C+Louis+H%3BLong%2C+Carole+A%3BMullen%2C+Gregory+ED&rft.aulast=Qian&rft.aufirst=Feng&rft.date=2008-05-01&rft.volume=26&rft.issue=20&rft.spage=2521&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Apical membrane antigen 1; Parasites; Enzyme-linked immunosorbent assay; Antibodies; Immunogenicity; Helper cells; Lymphocytes T; Immunoglobulin G; Membrane proteins; Vaccines; CpG islands; Oligonucleotides; Plasmodium falciparum; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1016/j.vaccine.2008.03.005 ER - TY - JOUR T1 - Exposure to disease agents in the endangered Iberian lynx (Lynx pardinus) AN - 19895185; 8638088 AB - The Iberian lynx (Lynx pardinus) is the most endangered felid species in the world. Lynx populations have decreased dramatically in size and distribution in the last four decades, thus becoming increasingly vulnerable to catastrophic events such as epizooties. From 1989 to 2000, serum samples were obtained from 48 free-ranging lynx captured in the Donana National Park (DNP, n = 31) and mountains of Sierra Morena (SM, n = 17) in southern Spain. Samples were tested for antibodies against Toxoplasma gondii, feline herpesvirus 1 (FHV-1), feline calicivirus (FCV), feline/canine parvovirus (FPV/CPV), feline coronavirus, feline immunodeficiency virus (FIV), feline leukaemia virus and canine distemper virus (CDV) and for FeLV p27 antigen, to document baseline exposure levels. Antibodies against T. gondii were detected in 44% of lynx, with a significantly greater prevalence in DNP (61%) than in SM (12%). In DNP, prevalence was significantly higher in adult (81%) than in juvenile and sub-adult (41%) lynx, but no such difference was observed in SM. Low prevalences (<=11%) of minimally positive titres were found for FHV-1, FCV and FPV/CPV. This, combined with the lack of evidence for exposure to CDV, FIV and FeLV, suggests that these lynx populations are naive and might be vulnerable to a disease outbreak in the future. Because of the reduced size of lynx populations, the documented low level of genetic variation (particularly in the DNP population) coupled with the recently documented state of immune depletion in a majority of necropsied lynx, it is important to better understand the threat and potential impact that disease agents might pose for the conservation of this endangered species. Future surveillance programs must include possible disease reservoir hosts such as domestic cats and dogs and other wild carnivores. JF - European Journal of Wildlife Research AU - Roelke, Melody E AU - Johnson, Warren E AU - Millan, Javier AU - Palomares, Francisco AU - Revilla, Eloy AU - Rodriguez, Alejandro AU - Calzada, Javier AU - Ferreras, Pablo AU - Leon-Vizcaino, Luis AU - Delibes, Miguel AU - O'Brien, Stephen J AD - Laboratory of Genomic Diversity, SAIC-Frederick, NCI-Frederick, Frederick, MD 21702-1201, USA, syngamustrachea@hotmail.com Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 171 EP - 178 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 54 IS - 2 SN - 1612-4642, 1612-4642 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Ecology Abstracts; Sustainability Science Abstracts KW - Andalusia KW - Conservation KW - Disease risk KW - Serosurvey KW - Spain KW - Feline immunodeficiency virus KW - Canine distemper virus KW - National parks KW - national parks KW - Genetic diversity KW - Lynx lynx KW - Spain, Andalucia, Donana Natl. Park KW - Lynx KW - Mountains KW - Leukemia KW - ANE, Spain, Galicia KW - Reservoirs KW - carnivores KW - Carnivores KW - Feline leukemia virus KW - genetic diversity KW - outbreaks KW - Feline coronavirus KW - Antibodies KW - Canine parvovirus KW - Canine distemper KW - Toxoplasma gondii KW - Feline calicivirus KW - Disease reservoirs KW - Endangered species KW - vulnerability KW - Feline herpesvirus 1 KW - V 22360:AIDS and HIV KW - M3 1010:Issues in Sustainable Development KW - K 03420:Plant Diseases KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Wildlife+Research&rft.atitle=Exposure+to+disease+agents+in+the+endangered+Iberian+lynx+%28Lynx+pardinus%29&rft.au=Roelke%2C+Melody+E%3BJohnson%2C+Warren+E%3BMillan%2C+Javier%3BPalomares%2C+Francisco%3BRevilla%2C+Eloy%3BRodriguez%2C+Alejandro%3BCalzada%2C+Javier%3BFerreras%2C+Pablo%3BLeon-Vizcaino%2C+Luis%3BDelibes%2C+Miguel%3BO%27Brien%2C+Stephen+J&rft.aulast=Roelke&rft.aufirst=Melody&rft.date=2008-05-01&rft.volume=54&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Wildlife+Research&rft.issn=16124642&rft_id=info:doi/10.1007%2Fs10344-007-0122-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mountains; Antibodies; Canine distemper; Carnivores; National parks; Disease reservoirs; Genetic diversity; Conservation; Endangered species; Leukemia; carnivores; national parks; genetic diversity; vulnerability; outbreaks; Reservoirs; Lynx; Canine parvovirus; Toxoplasma gondii; Feline immunodeficiency virus; Feline calicivirus; Canine distemper virus; Feline leukemia virus; Lynx lynx; Feline herpesvirus 1; Feline coronavirus; ANE, Spain, Galicia; Spain; Spain, Andalucia, Donana Natl. Park DO - http://dx.doi.org/10.1007/s10344-007-0122-2 ER - TY - JOUR T1 - Ring-expanded Nucleosides (RENs) Exhibit Potent ATP-dependent Helicase Activity of RNA Helicase DDX3 with Little or no Toxicity in Ex Vivo Cell Culture or In Vivo in Mice AN - 19886125; 8254107 JF - Antiviral Research AU - Yedavalli, V AU - Zhang, N AU - Cai, H AU - Jeang, K T AU - Hosmane, R AD - National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 78 IS - 2 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - RNA helicase KW - nucleosides KW - Cell culture KW - Toxicity KW - DNA helicase KW - V 22410:Animal Diseases KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19886125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Ring-expanded+Nucleosides+%28RENs%29+Exhibit+Potent+ATP-dependent+Helicase+Activity+of+RNA+Helicase+DDX3+with+Little+or+no+Toxicity+in+Ex+Vivo+Cell+Culture+or+In+Vivo+in+Mice&rft.au=Yedavalli%2C+V%3BZhang%2C+N%3BCai%2C+H%3BJeang%2C+K+T%3BHosmane%2C+R&rft.aulast=Yedavalli&rft.aufirst=V&rft.date=2008-05-01&rft.volume=78&rft.issue=2&rft.spage=A68&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2008.01.150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - RNA helicase; nucleosides; Cell culture; Toxicity; DNA helicase DO - http://dx.doi.org/10.1016/j.antiviral.2008.01.150 ER - TY - JOUR T1 - Identification of innate immunity genes and pathways using a comparative genomics approach AN - 19881706; 8203375 AB - To reveal regulators of innate immunity, we used RNAi assays to monitor the immune response when genes are inhibited in Caenorhabditis elegans and mouse macrophages. Genes that altered innate immune responsiveness in C. elegans were validated in murine macrophages, resulting in the discovery of 11 genes that regulate the innate immune response in both systems and the subsequent identification of a protein interaction network with a conserved role in innate immunity regulation. We confirmed the role of four of these 11 genes in antimicrobial gene regulation using available mutants in C. elegans. Several of these genes (acy-1, tub-2, and tbc-1) also regulate susceptibility to the pathogen Pseudomonas aeruginosa. These genes may prove critical to understanding host defense and represent potential therapeutic targets for infectious and immunological diseases. JF - Proceedings of the National Academy of Sciences, USA AU - Alper, Scott AU - Laws, Rebecca AU - Lackford, Brad AU - Boyd, Windy A AU - Dunlap, Paul AU - Freedman, Jonathan H AU - Schwartz, David A AD - Laboratory of Environmental Lung Disease, National Heart Lung and Blood Institute, and Laboratory of Molecular Toxicology, National Institutes of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Durham, NC 27709 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 7016 EP - 7021 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 19 SN - 0027-8424, 0027-8424 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Genetics Abstracts KW - Macrophages KW - Transcription KW - Immunity KW - Pathogens KW - Antimicrobial agents KW - Immunological diseases KW - Gene regulation KW - Caenorhabditis elegans KW - RNA-mediated interference KW - Immune response KW - genomics KW - Pseudomonas aeruginosa KW - G 07720:Immunogenetics KW - N 14830:RNA KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19881706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Identification+of+innate+immunity+genes+and+pathways+using+a+comparative+genomics+approach&rft.au=Alper%2C+Scott%3BLaws%2C+Rebecca%3BLackford%2C+Brad%3BBoyd%2C+Windy+A%3BDunlap%2C+Paul%3BFreedman%2C+Jonathan+H%3BSchwartz%2C+David+A&rft.aulast=Alper&rft.aufirst=Scott&rft.date=2008-05-01&rft.volume=105&rft.issue=19&rft.spage=7016&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Immunological diseases; Macrophages; Gene regulation; RNA-mediated interference; Transcription; genomics; Pathogens; Immune response; Immunity; Antimicrobial agents; Caenorhabditis elegans; Pseudomonas aeruginosa ER - TY - JOUR T1 - Investigating the neural basis for fMRI-based functional connectivity in a blocked design: application to interregional correlations and psycho-physiological interactions AN - 19806883; 8585966 AB - This paper investigates how well different kinds of fMRI functional connectivity analysis reflect the underlying interregional neural interactions. This is hard to evaluate using real experimental data where such relationships are unknown. Rather, we use a biologically realistic neural model to simulate both neuronal activities and multiregional fMRI data from a blocked design. Because we know how every element in the model is related to every other element, we can compare functional connectivity measurements across different spatial and temporal scales. We focus on (1) psycho-physiological interaction (PPI) analysis, which is a simple brain connectivity method that characterizes the activity in one brain region by the interaction between another region's activity and a psychological factor, and (2) interregional correlation analysis. We investigated the neurobiological underpinnings of PPI using simulated neural activities and fMRI signals generated by a large-scale neural model that performs a visual delayed match-to-sample task. Simulated fMRI data are generated by convolving integrated synaptic activities (ISAs) with a hemodynamic response function. The simulation was done under three task conditions: high-attention, low-attention and a control task ('passive viewing'). We investigated how biological and scanning parameters affect PPI and compared these with functional connectivity measures obtained using correlation analysis. We performed correlational and PPI analyses with three types of time-series data: ISA, fMRI and deconvolved fMRI (which yields estimated neural signals) obtained using a deconvolution algorithm. The simulated ISA can be considered as the 'gold standard' because it represents the underlying neural activity. Our main findings show (1) that evaluating the change in an interregional functional connection using the difference in regression coefficients (as is essentially done in the PPI method) produces results that better reflect the underlying changes in neural interrelationships than does evaluating the functional connectivity difference as a change in correlation coefficient; (2) that using fMRI and deconvolved fMRI data led to similar conclusions in the PPI-based functional connectivity results, and these generally agreed with the nature of the underlying neural interactions; and (3) the functional connectivity correlation measures often led to different conclusions regarding significance for different scanning and hemodynamic parameters, but the significances of the PPI regression parameters were relatively robust. These results highlight the way in which neural modeling can be used to help validate the inferences one can make about functional connectivity based on fMRI data. JF - Magnetic Resonance Imaging AU - Kim, Jieun AU - Horwitz, Barry AD - Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA, horwitzb@nidcd.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 583 EP - 593 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 5 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neural modeling KW - fMRI KW - Brain KW - Hemodynamic response function KW - Deconvolution KW - Brain mapping KW - Data processing KW - Scanning KW - Neural networks KW - Functional magnetic resonance imaging KW - Algorithms KW - Hemodynamics KW - Correlation analysis KW - W 30910:Imaging KW - N3 11002:Computational & theoretical neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19806883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Investigating+the+neural+basis+for+fMRI-based+functional+connectivity+in+a+blocked+design%3A+application+to+interregional+correlations+and+psycho-physiological+interactions&rft.au=Kim%2C+Jieun%3BHorwitz%2C+Barry&rft.aulast=Kim&rft.aufirst=Jieun&rft.date=2008-05-01&rft.volume=26&rft.issue=5&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2007.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Brain mapping; Data processing; Scanning; Neural networks; Functional magnetic resonance imaging; Algorithms; Hemodynamics; Correlation analysis DO - http://dx.doi.org/10.1016/j.mri.2007.10.011 ER - TY - JOUR T1 - TLR6 Modulates First Trimester Trophoblast Responses to Peptidoglycan AN - 19806105; 8201032 AB - Intrauterine bacterial infections are a well-established cause of pregnancy complications. One key observation in a number of abnormal pregnancies is that placental apoptosis is significantly elevated. First trimester trophoblast cells are known to express TLR1 and TLR2 and to undergo apoptosis following exposure to Gram-positive bacterial peptidoglycan (PDG). Thus, the objectives of this study were to determine whether PDG-induced pregnancy complications are associated with placental apoptosis and to characterize the cellular mechanisms involved. We have demonstrated, using an animal model, that delivery of PDG to pregnant mice early in gestation resulted in highly elevated placental apoptosis, evidenced by trophoblast M-30 and active caspase 3 immunostaining. Using an in vitro model of human first trimester trophoblasts, apoptosis induced by PDG was found to be mediated by both TLR1 and TLR2 and that this could be blocked by the presence of TLR6. Furthermore, in the presence of TLR6, exposure to PDG resulted in trophoblast NF- Kappa B activation and triggered these cells to secrete IL-8 and IL-6. The findings of this study suggest that a Gram-positive bacterial infection, through TLR2 and TLR1, may directly promote the elevated trophoblast cell death and that this may be the underlying mechanism of pregnancy complications, such as preterm delivery. Furthermore, the expression of TLR6 may be a key factor in determining whether the response to PDG would be apoptosis or inflammation. JF - Journal of Immunology AU - Abrahams, Vikki M AU - Aldo, Paulomi B AU - Murphy, Shaun P AU - Visintin, Irene AU - Koga, Kaori AU - Wilson, Gabriella AU - Romero, Roberto AU - Sharma, Surendra AU - Mor, Gil AD - Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520. Department of Pediatrics and. Department of Pathology, Women and Infants' Hospital, Rhode Island Hospital-Brown University, Providence, RI 02903. Perinatology Research Branch, National Institute of Child Health and Human Development, Detroit, MI 48201 Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 6035 EP - 6043 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 9 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Apoptosis KW - TLR2 protein KW - Animal models KW - peptidoglycans KW - Trophoblasts KW - Infection KW - Interleukin 8 KW - Pregnancy KW - Inflammation KW - NF- Kappa B protein KW - Pregnancy complications KW - Placenta KW - Gestation KW - TLR1 protein KW - Caspase-3 KW - Toll-like receptors KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19806105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=TLR6+Modulates+First+Trimester+Trophoblast+Responses+to+Peptidoglycan&rft.au=Abrahams%2C+Vikki+M%3BAldo%2C+Paulomi+B%3BMurphy%2C+Shaun+P%3BVisintin%2C+Irene%3BKoga%2C+Kaori%3BWilson%2C+Gabriella%3BRomero%2C+Roberto%3BSharma%2C+Surendra%3BMor%2C+Gil&rft.aulast=Abrahams&rft.aufirst=Vikki&rft.date=2008-05-01&rft.volume=180&rft.issue=9&rft.spage=6035&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Apoptosis; TLR2 protein; Animal models; Trophoblasts; peptidoglycans; Infection; Interleukin 8; NF- Kappa B protein; Inflammation; Pregnancy; Pregnancy complications; Placenta; Gestation; Caspase-3; TLR1 protein; Toll-like receptors ER - TY - JOUR T1 - Mapping spatiotemporal diffusion inside the human brain using a numerical solution of the diffusion equation AN - 19806007; 8585979 AB - Diffusion is an important mechanism for molecular transport in living biological tissues. Diffusion magnetic resonance imaging (dMRI) provides a unique probe to examine microscopic structures of the tissues in vivo, but current dMRI techniques usually ignore the spatiotemporal evolution process of the diffusive medium. In the present study, we demonstrate the feasibility to reveal the spatiotemporal diffusion process inside the human brain based on a numerical solution of the diffusion equation. Normal human subjects were scanned with a diffusion tensor imaging (DTI) technique on a 3-T MRI scanner, and the diffusion tensor in each voxel was calculated from the DTI data. The diffusion equation, a partial-derivative description of Fick's law for the diffusion process, was discretized into equivalent algebraic equations. A finite- difference method was employed to obtain the numerical solution of the diffusion equation with a Crank- Nicholson iteration scheme to enhance the numerical stability. By specifying boundary and initial conditions, the spatiotemporal evolution of the diffusion process inside the brain can be virtually reconstructed. Our results exhibit similar medium profiles and diffusion coefficients as those of light fluorescence dextrans measured in integrative optical imaging experiments. The proposed method highlights the feasibility to noninvasively estimate the macroscopic diffusive transport time for a molecule in a given region of the brain. JF - Magnetic Resonance Imaging AU - Zhan, Wang AU - Jiang, Li AU - Loew, Murray H AU - Yang, Yihong AD - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA, yihongyang@intra.nida.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 694 EP - 702 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 5 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Diffusion equation KW - Diffusion tensor imaging (DTI) KW - Numerical solution KW - Spatiotemporal process KW - Dextran KW - Brain mapping KW - Neuroimaging KW - Fluorescence KW - Data processing KW - Mathematical models KW - Magnetic resonance imaging KW - Probes KW - Brain KW - Light effects KW - Boundaries KW - Diffusion coefficient KW - Evolution KW - W 30910:Imaging KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19806007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Mapping+spatiotemporal+diffusion+inside+the+human+brain+using+a+numerical+solution+of+the+diffusion+equation&rft.au=Zhan%2C+Wang%3BJiang%2C+Li%3BLoew%2C+Murray+H%3BYang%2C+Yihong&rft.aulast=Zhan&rft.aufirst=Wang&rft.date=2008-05-01&rft.volume=26&rft.issue=5&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2008.01.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dextran; Brain mapping; Neuroimaging; Mathematical models; Data processing; Fluorescence; Magnetic resonance imaging; Brain; Probes; Light effects; Boundaries; Diffusion coefficient; Evolution DO - http://dx.doi.org/10.1016/j.mri.2008.01.025 ER - TY - JOUR T1 - SarZ Is a Key Regulator of Biofilm Formation and Virulence in Staphylococcus epidermidis AN - 19797084; 8612615 AB - Biofilm-associated infection due to Staphylococcus epidermidis, the leading nosocomlal pathogen. is a major problem for the public health system, but the regulation of this important phenotype is not completely understood. Using a highly discriminatory screening procedure for genes that influence blofilm formation, we identified the transcriptional regulator SarZ as a novel important determinant of biofilm formation and biofilm-associated infection, on the basis of the significant impact of sarZ on the transcription of the biosynthetic operon for biofilm exopolysaccharide. In addition, sarZ influenced the expression of a series of virulence genes, including genes that influence the expression of lipases and proteases, resistance to an important human antimicrobial peptide, and hemolysis. Our study indicates that the SarZ regulator has a key role in maintaining the typical S. epidermidis phenotype, which is characterized by pronounced blofilm formation and immune evasion, a likely reason for the success of S. epidermidis as a colonizing organism and pathogen in chronic, biofllm-assodated infection. JF - Journal of Infectious Diseases AU - Wang, L AU - Li, M AU - Dong, D AU - Bach, T-HL AU - Sturdevant, DE AU - Vuong, C AU - Otto, M AU - Gao, Q AD - Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA, motto@niald.nlh.gov Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 1254 EP - 1262 VL - 197 IS - 9 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology KW - Transcription KW - Pathogens KW - exopolysaccharides KW - Public health KW - Virulence KW - Triacylglycerol lipase KW - Chronic infection KW - Hemolysis KW - Proteinase KW - Biofilms KW - Operons KW - Staphylococcus epidermidis KW - Antimicrobial peptides KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19797084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=SarZ+Is+a+Key+Regulator+of+Biofilm+Formation+and+Virulence+in+Staphylococcus+epidermidis&rft.au=Wang%2C+L%3BLi%2C+M%3BDong%2C+D%3BBach%2C+T-HL%3BSturdevant%2C+DE%3BVuong%2C+C%3BOtto%2C+M%3BGao%2C+Q&rft.aulast=Wang&rft.aufirst=L&rft.date=2008-05-01&rft.volume=197&rft.issue=9&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F586714 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virulence; Triacylglycerol lipase; Chronic infection; Hemolysis; Transcription; Proteinase; Pathogens; Biofilms; Operons; exopolysaccharides; Antimicrobial peptides; Public health; Staphylococcus epidermidis DO - http://dx.doi.org/10.1086/586714 ER - TY - JOUR T1 - Trends in Intussusception Hospitalizations Among US Infants, 1993-2004: Implications for Monitoring the Safety of the New Rotavirus Vaccination Program AN - 19794377; 8202803 AB - OBJECTIVES. In 2006, a new rotavirus vaccine was recommended for routine immunization of US infants. Because a previous rotavirus vaccine was withdrawn in 1999 after it was associated with intussusception, monitoring for this adverse event with the new vaccine is important. The objectives of this study were to assess intussusception hospitalizations trends among US infants for 1993 to 2004; provide estimates of hospitalization rates for intussusception for 2002-2004; and assess variations in background rates by age, race/ethnicity, and surgical management. METHODS. By using the Healthcare Cost and Utilization Project's State Inpatient Database that captures US hospital discharges from 16 states representing 49% of the birth cohort during 1993-2004 and from 35 states representing 85% of the birth cohort in 2002-2004, we examined hospitalizations among infants (<12 months of age) with an International Classification of Disease, Ninth Revision, Clinical Modification code for intussusception (560.0). Incidence rates were calculated by using census data, and rate ratios with 95% confidence intervals were calculated by using Poisson regression data. RESULTS. Annual intussusception hospitalization rates declined 25% from 1993 to 2004 but have remained stable at similar to 35 cases per 100000 infants since 2000. Rates were very low for infants younger than 9 weeks (<5 per 100000) then increased rapidly, peaking at similar to 62 per 100000 at 26 to 29 weeks, before declining gradually to 26 per 100000 at 52 weeks. Compared with rates among non-Hispanic white infants (27 per 100000), rates were greater among non-Hispanic black infants (37 per 100000) and Hispanic infants (45 per 100000); however, rates did not differ by race/ethnicity for infants who were younger than 16 weeks. CONCLUSIONS. This assessment of US hospitalizations provides up-to-date and nationally representative prevaccine rates of intussusception. Because rates varied almost 12-fold by week of age and to a lesser extent by race/ethnicity during the age of vaccination, adjusting baseline rates to reflect the demographics of the vaccinated population will be crucial for assessing risk for intussusception after rotavirus vaccination. JF - Pediatrics AU - Tate, Jacqueline E AU - Simonsen, Lone AU - Viboud, Cecile AU - Steiner, Claudia AU - Patel, Manish M AU - Curns, Aaron T AU - Parashar, Umesh D AD - Division of Viral Diseases, Epidemiology Branch, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Fogarty International Center, National Institutes of Health, Bethesda, Maryland. Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, Maryland Y1 - 2008/05// PY - 2008 DA - May 2008 SP - e1125 EP - e1132 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 5 SN - 0031-4005, 0031-4005 KW - Risk Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - Rotavirus KW - census KW - vaccines KW - Age KW - Vaccination KW - immunization KW - Demography KW - Databases KW - USA KW - Health care KW - Classification KW - intussusception KW - Census KW - Vaccines KW - Side effects KW - Ethnic groups KW - Races KW - Infants KW - Hospitals KW - R2 23060:Medical and environmental health KW - W 30915:Pharmaceuticals & Vaccines KW - V 22400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Trends+in+Intussusception+Hospitalizations+Among+US+Infants%2C+1993-2004%3A+Implications+for+Monitoring+the+Safety+of+the+New+Rotavirus+Vaccination+Program&rft.au=Tate%2C+Jacqueline+E%3BSimonsen%2C+Lone%3BViboud%2C+Cecile%3BSteiner%2C+Claudia%3BPatel%2C+Manish+M%3BCurns%2C+Aaron+T%3BParashar%2C+Umesh+D&rft.aulast=Tate&rft.aufirst=Jacqueline&rft.date=2008-05-01&rft.volume=121&rft.issue=5&rft.spage=e1125&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Demography; Databases; Age; Classification; intussusception; Census; Vaccines; Vaccination; Races; Ethnic groups; Hospitals; Infants; census; immunization; vaccines; Health care; Side effects; Rotavirus; USA ER - TY - JOUR T1 - Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPAR alpha and CAR AN - 19716169; 8204084 AB - A number of perfluorinated alkyl acids including perfluorooctanoic acid (PFOA) elicit effects similar to peroxisome proliferator chemicals (PPC) in mouse and rat liver. There is strong evidence that PPC cause many of their effects linked to liver cancer through the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR alpha ). To determine the role of PPAR alpha in mediating PFOA transcriptional events, we compared the transcript profiles of the livers of wild-type or PPAR alpha -null mice exposed to PFOA or the PPAR alpha agonist WY-14,643 (WY). After 7 days of exposure, 85% or 99.7% of the genes altered by PFOA or WY exposure, respectively were dependent on PPAR alpha . The PPAR alpha -independent genes regulated by PFOA included those involved in lipid homeostasis and xenobiotic metabolism. Many of the lipid homeostasis genes including acyl-CoA oxidase (Acox1) were also regulated by WY in a PPAR alpha -dependent manner. The increased expression of these genes in PPAR alpha -null mice may be partly due to increases in PPAR gamma expression upon PFOA exposure. Many of the identified xenobiotic metabolism genes are known to be under control of the nuclear receptor CAR (constitutive activated/androstane receptor) and the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2). There was excellent correlation between the transcript profile of PPAR alpha -independent PFOA genes and those of activators of CAR including phenobarbital and 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) but not those regulated by the Nrf2 activator, dithiol-3-thione. These results indicate that PFOA alters most genes in wild-type mouse liver through PPAR alpha , but that a subset of genes are regulated by CAR and possibly PPAR gamma in the PPAR alpha -null mouse. JF - Toxicological Sciences AU - Rosen, Mitchell B AU - Lee, Janice S AU - Ren, Hongzu AU - Vallanat, Beena AU - Liu, Jie AU - Waalkes, Michael P AU - Abbott, Barbara D AU - Lau, Christopher AU - Corton, JChristopher AD - NHEERL/ORD, U.S. EPA, Research Triangle Park, North Carolina 27711. NHEERL Toxicogenomics Core, U.S. EPA, Research Triangle Park, North Carolina 27711. National Cancer Institute, Research Triangle Park, North Carolina 27711 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 46 EP - 56 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 103 IS - 1 SN - 1096-6080, 1096-6080 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Phenobarbital KW - Peroxisome proliferator-activated receptors KW - Liver cancer KW - Lipids KW - Nuclear receptors KW - Transcription KW - perfluorooctanoic acid KW - Homeostasis KW - Benzene KW - Lipid metabolism KW - Acyl-CoA oxidase KW - Acids KW - Transcription factors KW - Metabolism KW - N 14835:Protein-Nucleic Acids Association KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toxicogenomic+Dissection+of+the+Perfluorooctanoic+Acid+Transcript+Profile+in+Mouse+Liver%3A+Evidence+for+the+Involvement+of+Nuclear+Receptors+PPAR+alpha+and+CAR&rft.au=Rosen%2C+Mitchell+B%3BLee%2C+Janice+S%3BRen%2C+Hongzu%3BVallanat%2C+Beena%3BLiu%2C+Jie%3BWaalkes%2C+Michael+P%3BAbbott%2C+Barbara+D%3BLau%2C+Christopher%3BCorton%2C+JChristopher&rft.aulast=Rosen&rft.aufirst=Mitchell&rft.date=2008-05-01&rft.volume=103&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phenobarbital; Peroxisome proliferator-activated receptors; Nuclear receptors; Lipids; Liver cancer; Transcription; perfluorooctanoic acid; Homeostasis; Benzene; Acyl-CoA oxidase; Lipid metabolism; Transcription factors; Acids; Metabolism ER - TY - JOUR T1 - The sim Operon Facilitates the Transport and Metabolism of Sucrose Isomers in Lactobacillus casei ATCC 334 AN - 19712754; 8199488 AB - Inspection of the genome sequence of Lactobacillus casei ATCC 334 revealed two operons that might dissimilate the five isomers of sucrose. To test this hypothesis, cells of L. casei ATCC 334 were grown in a defined medium supplemented with various sugars, including each of the five isomeric disaccharides. Extracts prepared from cells grown on the sucrose isomers contained high levels of two polypeptides with M sub(r)s of similar to 50,000 and similar to 17,500. Neither protein was present in cells grown on glucose, maltose or sucrose. Proteomic, enzymatic, and Western blot analyses identified the similar to 50-kDa protein as an NAD super(+)- and metal ion-dependent phospho- alpha -glucosidase. The oligomeric enzyme was purified, and a catalytic mechanism is proposed. The smaller polypeptide represented an EIIA component of the phosphoenolpyruvate-dependent sugar phosphotransferase system. Phospho- alpha -glucosidase and EIIA are encoded by genes at the LSEI_0369 (simA) and LSEI_0374 (simF) loci, respectively, in a block of seven genes comprising the sucrose isomer metabolism (sim) operon. Northern blot analyses provided evidence that three mRNA transcripts were up-regulated during logarithmic growth of L. casei ATCC 334 on sucrose isomers. Internal simA and simF gene probes hybridized to similar to 1.5- and similar to 1.3-kb transcripts, respectively. A 6.8-kb mRNA transcript was detected by both probes, which was indicative of cotranscription of the entire sim operon. JF - Journal of Bacteriology AU - Thompson, John AU - Jakubovics, Nicholas AU - Abraham, Bindu AU - Hess, Sonja AU - Pikis, Andreas AD - Microbial Biochemistry and Genetics Unit. Oral Biofilm Communication Unit. Oral Infection and Immunity Branch, NIDCR, and the Proteomics and Mass Spectrometry Facility, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892 Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 3362 EP - 3373 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 9 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Lactobacillus casei KW - Genomes KW - Western blotting KW - Metals KW - Sugar KW - Cotranscription KW - Nucleotide sequence KW - DNA probes KW - Glucose KW - Enzymes KW - phosphotransferase KW - Disaccharides KW - Isomers KW - Sucrose KW - proteomics KW - Operons KW - Metabolism KW - Maltose KW - J 02320:Cell Biology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19712754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+sim+Operon+Facilitates+the+Transport+and+Metabolism+of+Sucrose+Isomers+in+Lactobacillus+casei+ATCC+334&rft.au=Thompson%2C+John%3BJakubovics%2C+Nicholas%3BAbraham%2C+Bindu%3BHess%2C+Sonja%3BPikis%2C+Andreas&rft.aulast=Thompson&rft.aufirst=John&rft.date=2008-05-01&rft.volume=190&rft.issue=9&rft.spage=3362&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Sugar; Metals; Western blotting; Cotranscription; DNA probes; Nucleotide sequence; Glucose; Enzymes; phosphotransferase; Isomers; Disaccharides; Sucrose; proteomics; Operons; Metabolism; Maltose; Lactobacillus casei ER - TY - JOUR T1 - Regulation of Gene Expression in a Mixed-Genus Community: Stabilized Arginine Biosynthesis in Streptococcus gordonii by Coaggregation with Actinomyces naeslundii AN - 19705198; 8199356 AB - Interactions involving genetically distinct bacteria, for example, between oral streptococci and actinomyces, are central to dental plaque development. A DNA microarray identified Streptococcus gordonii genes regulated in response to coaggregation with Actinomyces naeslundii. The expression of 23 genes changed >3-fold in coaggregates, including that of 9 genes involved in arginine biosynthesis and transport. The capacity of S. gordonii to synthesize arginine was assessed using a chemically defined growth medium. In monoculture, streptococcal arginine biosynthesis was inefficient and streptococci could not grow aerobically at low arginine concentrations. In dual-species cultures containing coaggregates, however, S. gordonii grew to high cell density at low arginine concentrations. Equivalent cocultures without coaggregates showed no growth until coaggregation was evident (9 h). An argH mutant was unable to grow at low arginine concentrations with or without A. naeslundii, indicating that arginine biosynthesis was essential for coaggregation-induced streptococcal growth. Using quantitative reverse transcriptase PCR, the expression of argC, argG, and pyrA sub(b) was strongly (10- to 100-fold) up-regulated in S. gordonii monocultures after 3 h of growth when exogenous arginine was depleted. Cocultures without induced coaggregation showed similar regulation. However, within 1 h after coaggregation with A. naeslundii, the expression of argC, argG, and pyrA sub(b) in S. gordonii was partially up-regulated although arginine was plentiful, and mRNA levels did not increase further when arginine was diminished. Thus, A. naeslundii stabilizes S. gordonii expression of arginine biosynthesis genes in coaggregates but not cocultures and enables aerobic growth when exogenous arginine is limited. JF - Journal of Bacteriology AU - Jakubovics, Nicholas S AU - Gill, Steven R AU - Iobst, Stacey E AU - Vickerman, M M AU - Kolenbrander, Paul E AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, Bethesda, Maryland 20892. Department of Oral Biology. Department of Periodontics and Endodontics, University at Buffalo School of Dentistry, Buffalo, New York. Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850 Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 3646 EP - 3657 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 10 SN - 0021-9193, 0021-9193 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Gene expression KW - Streptococcus gordonii KW - Arginine KW - Cell density KW - RNA-directed DNA polymerase KW - Polymerase chain reaction KW - Cell culture KW - Dental plaque KW - Actinomyces naeslundii KW - DNA microarrays KW - J 02310:Genetics & Taxonomy KW - W 30910:Imaging KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19705198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Regulation+of+Gene+Expression+in+a+Mixed-Genus+Community%3A+Stabilized+Arginine+Biosynthesis+in+Streptococcus+gordonii+by+Coaggregation+with+Actinomyces+naeslundii&rft.au=Jakubovics%2C+Nicholas+S%3BGill%2C+Steven+R%3BIobst%2C+Stacey+E%3BVickerman%2C+M+M%3BKolenbrander%2C+Paul+E&rft.aulast=Jakubovics&rft.aufirst=Nicholas&rft.date=2008-05-01&rft.volume=190&rft.issue=10&rft.spage=3646&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Arginine; Cell density; Polymerase chain reaction; RNA-directed DNA polymerase; Cell culture; Dental plaque; DNA microarrays; Streptococcus gordonii; Actinomyces naeslundii ER - TY - JOUR T1 - Maturation of West Nile Virus Modulates Sensitivity to Antibody-Mediated Neutralization AN - 19670346; 9042612 AB - West Nile virions incorporate 180 envelope (E) proteins that orchestrate the process of virus entry and are the primary target of neutralizing antibodies. The E proteins of newly synthesized West Nile virus (WNV) are organized into trimeric spikes composed of pre-membrane (prM) and E protein heterodimers. During egress, immature virions undergo a protease-mediated cleavage of prM that results in a reorganization of E protein into the pseudo-icosahedral arrangement characteristic of mature virions. While cleavage of prM is a required step in the virus life cycle, complete maturation is not required for infectivity and infectious virions may be heterogeneous with respect to the extent of prM cleavage. In this study, we demonstrate that virion maturation impacts the sensitivity of WNV to antibody-mediated neutralization. Complete maturation results in a significant reduction in sensitivity to neutralization by antibodies specific for poorly accessible epitopes that comprise a major component of the human antibody response following WNV infection or vaccination. This reduction in neutralization sensitivity reflects a decrease in the accessibility of epitopes on virions to levels that fall below a threshold required for neutralization. Thus, in addition to a role in facilitating viral entry, changes in E protein arrangement associated with maturation modulate neutralization sensitivity and introduce an additional layer of complexity into humoral immunity against WNV. Author Summary West Nile virus (WNV) virions incorporate 180 envelope (E) proteins that are the primary target of neutralizing antibodies. As newly formed WNV virions are released from infected cells, the E proteins undergo a significant organizational change associated with maturation into an infectious virus. However, this process is not always efficient, as populations of infectious WNV include virions that did not complete the maturation process and may be heterogeneous with respect to the arrangement of E proteins on the virion. In this study, we found that neutralization by antibodies specific for epitopes commonly recognized in vivo is strongly impacted by the maturation state of WNV. Our studies suggest that maturation of WNV reduces the accessibility of some, but not all, epitopes on the virion for antibody binding. Virions that retain some immature character can be neutralized by monoclonal antibodies that fail to block infection of populations of WNV composed solely of mature virions. Similar results were found using polyclonal human serum obtained from volunteers of two clinical trials of candidate WNV vaccines. These studies identify unappreciated aspects of the antigenic complexity of WNV and highlight the importance of understanding the heterogenous forms of WNV that may be introduced into or replicating within the host. JF - PLoS Pathogens AU - Nelson, Steevenson AU - Jost, Christiane A AU - Xu, Qinq AU - Ess, Jessica AU - Martin, Julie E AU - Oliphant, Theodore AU - Whitehead, Stephen S AU - Durbin, Anna P AU - Graham, Barney S AU - Diamond, Michael S AU - Pierson, Theodore C AU - Buchmeier, Michael J AD - Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 4 IS - 5 SN - 1553-7366, 1553-7366 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Q5 01524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19670346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=Maturation+of+West+Nile+Virus+Modulates+Sensitivity+to+Antibody-Mediated+Neutralization&rft.au=Nelson%2C+Steevenson%3BJost%2C+Christiane+A%3BXu%2C+Qinq%3BEss%2C+Jessica%3BMartin%2C+Julie+E%3BOliphant%2C+Theodore%3BWhitehead%2C+Stephen+S%3BDurbin%2C+Anna+P%3BGraham%2C+Barney+S%3BDiamond%2C+Michael+S%3BPierson%2C+Theodore+C%3BBuchmeier%2C+Michael+J&rft.aulast=Nelson&rft.aufirst=Steevenson&rft.date=2008-05-01&rft.volume=4&rft.issue=5&rft.spage=e1000060&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1000060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1371/journal.ppat.1000060 ER - TY - JOUR T1 - Virus-Like Display of a Neo-Self Antigen Reverses B Cell Anergy in a B Cell Receptor Transgenic Mouse Model AN - 19529478; 8201008 AB - The ability to distinguish between self and foreign Ags is a central feature of immune recognition. For B cells, however, immune tolerance is not absolute, and factors that include Ag valency, the availability of T help, and polyclonal B cell stimuli can influence the induction of autoantibody responses. Here, we evaluated whether multivalent virus-like particle (VLP)-based immunogens could induce autoantibody responses in well-characterized transgenic (Tg) mice that express a soluble form of hen egg lysozyme (HEL) and in which B cell tolerance to HEL is maintained by anergy. Immunization with multivalent VLP-arrayed HEL, but not a trivalent form of HEL, induced high-titer Ab responses against HEL in both soluble HEL Tg mice and double Tg mice that also express a monoclonal HEL-specific BCR. Induction of autoantibodies against HEL was not dependent on coadministration of strong adjuvants, such as CFA. In contrast to previous data showing the T-independent induction of Abs to foreign epitopes on VLPs, the ability of HEL-conjugated VLPs to induce anti-HEL Abs in tolerant mice was dependent on the presence of CD4 super(+) Th cells, and could be enhanced by the presence of pre-existing cognate T cells. In in vitro studies, VLP-conjugated HEL was more potent than trivalent HEL in up-regulating surface activation markers on purified anergic B cells. Moreover, immunization with VLP-HEL reversed B cell anergy in vivo in an adoptive transfer model. Thus, Ag multivalency and T help cooperate to reverse B cell anergy, a major mechanism of B cell tolerance. JF - Journal of Immunology AU - Chackerian, Bryce AU - Durfee, Marisa R AU - Schiller, John T AD - Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico, Albuquerque, NM 87131. Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/05/01/ PY - 2008 DA - 2008 May 01 SP - 5816 EP - 5825 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 9 SN - 0022-1767, 0022-1767 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Lysozyme KW - Valency KW - Virus-like particles KW - Data processing KW - Lymphocytes B KW - Helper cells KW - Animal models KW - Adjuvants KW - Transgenic mice KW - Immunological tolerance KW - Immunization KW - Cell activation KW - CD4 antigen KW - Autoantibodies KW - Lymphocytes T KW - Adoptive transfer KW - Anergy KW - double prime B-cell receptor KW - Epitopes KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06930:Autoimmunity KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19529478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Virus-Like+Display+of+a+Neo-Self+Antigen+Reverses+B+Cell+Anergy+in+a+B+Cell+Receptor+Transgenic+Mouse+Model&rft.au=Chackerian%2C+Bryce%3BDurfee%2C+Marisa+R%3BSchiller%2C+John+T&rft.aulast=Chackerian&rft.aufirst=Bryce&rft.date=2008-05-01&rft.volume=180&rft.issue=9&rft.spage=5816&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Lysozyme; Valency; Data processing; Virus-like particles; Lymphocytes B; Helper cells; Animal models; Adjuvants; Transgenic mice; Immunological tolerance; Immunization; Cell activation; CD4 antigen; Autoantibodies; Adoptive transfer; Lymphocytes T; Anergy; double prime B-cell receptor; Epitopes ER - TY - JOUR T1 - An improved synthesis of arsenic-biotin conjugates AN - 19502326; 8807965 AB - An amide linked conjugate of p-aminophenylarsine oxide and biotin is conveniently prepared in a one-pot procedure by the reaction of biotinyl chloride, formed in situ, with p-aminophenyldichloroarsine. The reaction of the arsine oxide-biotin conjugate with 1,2-ethanedithiol produces the stabilized dithiarsolane. These reagents are now readily available for a variety of applications. JF - Bioorganic and Medicinal Chemistry AU - Heredia-Moya, Jorge AU - Kirk, Kenneth L AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA, kennethk@bdg8.niddk.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 5743 EP - 5746 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 10 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Arsine KW - oxides KW - Chloride KW - amides KW - Biotin KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19502326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=An+improved+synthesis+of+arsenic-biotin+conjugates&rft.au=Heredia-Moya%2C+Jorge%3BKirk%2C+Kenneth+L&rft.aulast=Heredia-Moya&rft.aufirst=Jorge&rft.date=2008-05-01&rft.volume=16&rft.issue=10&rft.spage=5743&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.03.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Arsine; oxides; Chloride; Biotin; amides DO - http://dx.doi.org/10.1016/j.bmc.2008.03.054 ER - TY - JOUR T1 - Type 2 diabetes has minimal effect on osseointegration of titanium implants in Psammomys obesus AN - 19477698; 8222875 AB - ObjectivesDental implants are routinely used with high success rates in generally healthy individuals. In contrast, their use in patients with uncontrolled diabetes mellitus (DM) remains controversial as altered bone healing around implants has been reported. The majority of reports addressing the issue of osseointegration of implants in animals were performed in beta -cell cytotoxic-induced Type I diabetes. In this study, we assessed the osseointegration of implants in Gerbil Psammomys obesus, a model of nutritionally induced Type 2 DM. Materials and methodsTitanium implants were inserted into the tibial medullary space of 140 male diabetic and control animals. One, 2, 4, and 8 weeks after implantation the tibias were removed for histomorphometric evaluation, which included trabecular bone volumes (TBV) and osseointegration. ResultsTwo weeks following implantation, diabetic animals had slightly less mature bone when compared with control animals. This distinction was not present 4 weeks after implantation. Interestingly, no correlation was found between ossetointegration or TBV and glucose and insulin levels. Furthermore, no difference in osseointegration and TBV values was seen between the groups. The heterogeneity of serum glucose and insulin levels in this model and the possible role of insulin in bone metabolism are discussed. ConclusionsNo significant difference in osseointegration and TBV was seen between diabetic and control P. obesus, a model of nutritionally induced Type 2 DM. JF - Clinical Oral Implants Research AU - Casap, Nardy AU - Nimri, Samer AU - Ziv, Ehud AU - Sela, Jona AU - Samuni, Yuval AD - Department of Oral and Maxillofacial Surgery and Faculty of Dental Medicine, Hebrew University Hadassah, Jerusalem, Israel, ysamuni@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 458 EP - 464 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 19 IS - 5 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - animals KW - diabetes KW - implants KW - Dental restorative materials KW - Titanium KW - Glucose KW - Beta cells KW - Insulin KW - Models KW - Bone (trabecular) KW - Diabetes mellitus KW - Bone healing KW - Tibia KW - Osseointegration KW - Bone turnover KW - Psammomys obesus KW - W 30920:Tissue Engineering KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Oral+Implants+Research&rft.atitle=Type+2+diabetes+has+minimal+effect+on+osseointegration+of+titanium+implants+in+Psammomys+obesus&rft.au=Casap%2C+Nardy%3BNimri%2C+Samer%3BZiv%2C+Ehud%3BSela%2C+Jona%3BSamuni%2C+Yuval&rft.aulast=Casap&rft.aufirst=Nardy&rft.date=2008-05-01&rft.volume=19&rft.issue=5&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Clinical+Oral+Implants+Research&rft.issn=1600-0501&rft_id=info:doi/10.1111%2Fj.1600-0501.2007.01495.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tibia; Bone healing; Diabetes mellitus; Dental restorative materials; Titanium; Glucose; Beta cells; Bone turnover; Osseointegration; Insulin; Bone (trabecular); Models; Psammomys obesus DO - http://dx.doi.org/10.1111/j.1600-0501.2007.01495.x ER - TY - JOUR T1 - Prostate cancer and metastasis initiating stem cells AN - 19477407; 8193933 AB - Androgen refractory prostate cancer metastasis is a major clinical challenge. Mechanism-based approaches to treating prostate cancer metastasis require an understanding of the developmental origin of the metastasis- initiating cell. Properties of prostate cancer metastases such as plasticity with respect to differentiated phenotype and androgen independence are consistent with the transformation of a prostate epithelial progenitor or stem cell leading to metastasis. This review focuses upon current evidence and concepts addressing the identification and properties of normal prostate stem or progenitor cells and their transformed counterparts. JF - Cell Research AU - Kelly, Kathleen AU - Yin, Juan Juan AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Building 37, Room 1068, Bethesda, MD 20892, USA, kellyka@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 PB - Science Press, Marketing and Sales Department 16 Donghuangchenggen Beijie St. Beijing 100717 People's Republic of China, [URL:http://www.chinainfo.gov.cn/periodical/dlxb/index.htm] VL - 18 IS - 5 SN - 1001-0602, 1001-0602 KW - Biotechnology and Bioengineering Abstracts KW - prostate cancer KW - metastasis KW - stem KW - progenitor KW - androgen KW - hedgehog KW - Metastases KW - Transformation KW - Stem cells KW - Prostate cancer KW - Reviews KW - Androgens KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19477407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Research&rft.atitle=Prostate+cancer+and+metastasis+initiating+stem+cells&rft.au=Kelly%2C+Kathleen%3BYin%2C+Juan+Juan&rft.aulast=Kelly&rft.aufirst=Kathleen&rft.date=2008-05-01&rft.volume=18&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Cell+Research&rft.issn=10010602&rft_id=info:doi/10.1038%2Fcr.2008.50 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Transformation; Metastases; Stem cells; Prostate cancer; Reviews; Androgens DO - http://dx.doi.org/10.1038/cr.2008.50 ER - TY - JOUR T1 - In Vitro Model of Bromodeoxyuridine or Iron Oxide Nanoparticle Uptake by Activated Macrophages from Labeled Stem Cells: Implications for Cellular Therapy AN - 19476157; 8305109 AB - There is increasing interest in using exogenous labels such as bromodeoxyuridine (BrdU) or superparamagnetic iron oxide nanoparticles (SPION) to label cells to identify transplanted cells and monitor their migration by fluorescent microscopy or in vivo magnetic resonance imaging (MRI), respectively. Direct implantation of cells into target tissue can result in >80% cell death due to trauma or apoptosis. Bystander uptake of labeled cells by activated macrophages (AM) can confound the interpretation of results. This study investigated the frequency of BrdU or SPION uptake by AM using the Boyden chamber model of inflammation. SPION/BrdU-labeled bone marrow stromal cells or HeLa cells, AM, and mouse fibroblasts (MF) or human fibroblasts (HF) were mixed in various ratios in Matrigel in the upper chamber and incubated for up to 96 hours. The AM were chemotactically induced to migrate to the lower chamber. Fluorescence-activated cell sorting analysis of AM from lower and upper chambers, in the presence of either MF or HF using anti-CD68, anti-BrdU, anti-dextran antibodies, revealed 10%-20% dextran-positive or 10% BrdU-positive AM after 96 hours of incubation. Transfer of iron to AM accounted for <10% of the total iron in labeled cells. The uptake of BrdU and SPION was dependent on the ratio of labeled cells to inflammatory cells and microenvironmental conditions. Direct implantation of BrdU/SPION-labeled cells into target tissue can result in uptake of label by AM; therefore, care should be taken to validate by histology transplanted cells for bystander cell markers and correlation with MRI results. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Pawelczyk, Edyta AU - Arbab, Ali S AU - Chaudhry, Aneeka AU - Balakumaran, Arun AU - Robey, Pamela G AU - Frank, Joseph A AD - Experimental Neuroimaging Section Laboratory of Diagnostic Radiology Research, Clinical Center, and Department of Radiology, Henry Ford Health System, Detroit, Michigan, USA. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1366 EP - 1375 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 5 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Bromodeoxyuridine KW - Macrophages KW - Apoptosis KW - iron oxides KW - stromal cells KW - Boyden chamber KW - Magnetic resonance imaging KW - Animal models KW - Bone marrow KW - Inflammation KW - Fibroblasts KW - Trauma KW - Flow cytometry KW - Leukocyte migration KW - Stem cells KW - Antibodies KW - Microscopy KW - Cell migration KW - Iron KW - nanoparticles KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19476157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=In+Vitro+Model+of+Bromodeoxyuridine+or+Iron+Oxide+Nanoparticle+Uptake+by+Activated+Macrophages+from+Labeled+Stem+Cells%3A+Implications+for+Cellular+Therapy&rft.au=Pawelczyk%2C+Edyta%3BArbab%2C+Ali+S%3BChaudhry%2C+Aneeka%3BBalakumaran%2C+Arun%3BRobey%2C+Pamela+G%3BFrank%2C+Joseph+A&rft.aulast=Pawelczyk&rft.aufirst=Edyta&rft.date=2008-05-01&rft.volume=26&rft.issue=5&rft.spage=1366&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Bromodeoxyuridine; Apoptosis; stromal cells; iron oxides; Boyden chamber; Magnetic resonance imaging; Bone marrow; Animal models; Trauma; Fibroblasts; Inflammation; Leukocyte migration; Flow cytometry; Antibodies; Stem cells; Microscopy; Cell migration; nanoparticles; Iron ER - TY - JOUR T1 - BAF250B-Associated SWI/SNF Chromatin-Remodeling Complex Is Required to Maintain Undifferentiated Mouse Embryonic Stem Cells AN - 19470500; 8305089 AB - Whether SWI/SNF chromatin remodeling complexes play roles in embryonic stem (ES) cells remains unknown. Here we show that SWI/SNF complexes are present in mouse ES cells, and their composition is dynamically regulated upon induction of ES cell differentiation. For example, the SWI/SNF purified from undifferentiated ES cells contains a high level of BAF155 and a low level of BAF170 (both of which are homologs of yeast SWI3 protein), whereas that from differentiated cells contains nearly equal amounts of both. Moreover, the levels of BAF250A and BAF250B decrease during the differentiation of ES cells, whereas that of BRM increases. The altered expression of SWI/SNF components hinted that these complexes could play roles in ES cell maintenance or differentiation. We therefore generated ES cells with biallelic inactivation of BAF250B and found that these cells display a reduced proliferation rate and an abnormal cell cycle. Importantly, these cells are deficient in the self-renewal capacity of undifferentiated ES cells and exhibit certain phenotypes of differentiated cells, including reduced expression of several pluripotency-related genes and increased expression of some differentiation-related genes. These data suggest that the BAF250B-associated SWI/SNF is essential for mouse ES cells to maintain their normal proliferation and pluripotency. The work presented here underscores the importance of SWI/SNF chromatin remodeling complexes in pluripotent stem cells. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Yan, Zhijiang AU - Wang, Zhong AU - Sharova, Lioudmila AU - Sharov, Alexei A AU - Ling, Chen AU - Piao, Yulan AU - Aiba, Kazuhiro AU - Matoba, Ryo AU - Wang, Weidong AU - Ko, Minoru SH AD - Genome Instability and Chromatin-Remodeling Section and Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA. Cardiovascular Research Center, Massachusetts General Hospital, Richard B. Simches Research Center, Harvard Medical School, Boston, Massachusetts, USA Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 1155 EP - 1165 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 5 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Differentiation KW - Stem cells KW - Data processing KW - Chromatin remodeling KW - Embryo cells KW - Cell cycle KW - Cell proliferation KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19470500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=BAF250B-Associated+SWI%2FSNF+Chromatin-Remodeling+Complex+Is+Required+to+Maintain+Undifferentiated+Mouse+Embryonic+Stem+Cells&rft.au=Yan%2C+Zhijiang%3BWang%2C+Zhong%3BSharova%2C+Lioudmila%3BSharov%2C+Alexei+A%3BLing%2C+Chen%3BPiao%2C+Yulan%3BAiba%2C+Kazuhiro%3BMatoba%2C+Ryo%3BWang%2C+Weidong%3BKo%2C+Minoru+SH&rft.aulast=Yan&rft.aufirst=Zhijiang&rft.date=2008-05-01&rft.volume=26&rft.issue=5&rft.spage=1155&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Data processing; Embryo cells; Chromatin remodeling; Cell cycle; Cell proliferation ER - TY - JOUR T1 - Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A sub(3) receptor-selective agonists AN - 19333605; 8685606 AB - 2-Chloro-5'-N-methylcarboxamidoadenosine analogues containing the (N)-methanocarba (bicyclo[3.1.0]hexane) ring system as a ribose substitute display increased selectivity as agonists of the human A sub(3) adenosine receptor (AR). However, the selectivity in mouse was greatly reduced due to an increased tolerance of this ring system at the mouse A sub(1)AR. Therefore, we varied substituents at the N super(6) and C2 positions in search of compounds that have improved A sub(3)AR selectivity and are species independent. An N super(6)-methyl analogue was balanced in affinity at mouse A sub(1)/A sub(3)ARs, with high selectivity in comparison to the A sub(2A)AR. Substitution of the 2-chloro atom with larger and more hydrophobic substituents, such as iodo and alkynyl groups, tended to increase the A sub(3)AR selectivity (up to 430-fold) in mouse and preserve it in human. Extended and chemically functionalized alkynyl chains attached at the C2 position of the purine moiety preserved A sub(3)AR selectivity more effectively than similar chains attached at the 3-position of the N super(6)-benzyl group. JF - Bioorganic and Medicinal Chemistry AU - Melman, Artem AU - Gao, Zhan-Guo AU - Kumar, Deepmala AU - Wan, Tina C AU - Gizewski, Elizabeth AU - Auchampach, John A AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8A, Room B1A-19, Bethesda, MD 20892-0810, USA, kajacobs@helix.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 2813 EP - 2819 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 9 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Adenosine receptors KW - Ribose KW - Hydrophobicity KW - purines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19333605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Design+of+%28N%29-methanocarba+adenosine+5%27-uronamides+as+species-independent+A+sub%283%29+receptor-selective+agonists&rft.au=Melman%2C+Artem%3BGao%2C+Zhan-Guo%3BKumar%2C+Deepmala%3BWan%2C+Tina+C%3BGizewski%2C+Elizabeth%3BAuchampach%2C+John+A%3BJacobson%2C+Kenneth+A&rft.aulast=Melman&rft.aufirst=Artem&rft.date=2008-05-01&rft.volume=18&rft.issue=9&rft.spage=2813&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2008.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Adenosine receptors; Ribose; Hydrophobicity; purines DO - http://dx.doi.org/10.1016/j.bmcl.2008.04.001 ER - TY - JOUR T1 - Estimating relative risks for common outcome using PROC NLP AN - 19331953; 8688850 AB - In cross-sectional or cohort studies with binary outcomes, it is biologically interpretable and of interest to estimate the relative risk or prevalence ratio, especially when the response rates are not rare. Several methods have been used to estimate the relative risk, among which the log- binomial models yield the maximum likelihood estimate (MLE) of the parameters. Because of restrictions on the parameter space, the log-binomial models often run into convergence problems. Some remedies, e.g., the Poisson and Cox regressions, have been proposed. However, these methods may give out- of-bound predicted response probabilities. In this paper, a new computation method using the SAS Nonlinear Programming (NLP) procedure is proposed to find the MLEs. The proposed NLP method was compared to the COPY method, a modified method to fit the log-binomial model. Issues in the implementation are discussed. For illustration, both methods were applied to data on the prevalence of microalbuminuria (micro-protein leakage into urine) for kidney disease patients from the Diabetes Control and Complications Trial. The sample SAS macro for calculating relative risk is provided in the appendix. JF - Computer Methods and Programs in Biomedicine AU - Yu, Binbing AU - Wang, Zhuoqiao AD - Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD 20892, USA, yubi@mail.nih.gov Y1 - 2008/05// PY - 2008 DA - May 2008 SP - 179 EP - 186 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo@elsevier.com], [URL:http://www.elsevier.nl] VL - 90 IS - 2 SN - 0169-2607, 0169-2607 KW - Biotechnology and Bioengineering Abstracts KW - Diabetes mellitus KW - Risk assessment KW - Leakage KW - Data processing KW - Convergence KW - Urine KW - Kidney diseases KW - Appendix KW - Computer applications KW - Clinical trials KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19331953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=Estimating+relative+risks+for+common+outcome+using+PROC+NLP&rft.au=Yu%2C+Binbing%3BWang%2C+Zhuoqiao&rft.aulast=Yu&rft.aufirst=Binbing&rft.date=2008-05-01&rft.volume=90&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2Fj.cmpb.2007.12.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Risk assessment; Models; Urine; Convergence; Data processing; Kidney diseases; Clinical trials; Leakage; Diabetes mellitus; Computer applications; Appendix DO - http://dx.doi.org/10.1016/j.cmpb.2007.12.010 ER - TY - JOUR T1 - Why we like to drink: a functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol. AN - 69161970; 18448634 AB - People typically drink alcohol to induce euphoria or reduce anxiety, and they frequently drink in social settings, yet the effect of alcohol on human brain circuits involved in reward and emotion has been explored only sparingly. We administered alcohol intravenously to social drinkers while brain response to visual threatening and nonthreatening facial stimuli was measured using functional magnetic resonance imaging (fMRI). Alcohol robustly activated striatal reward circuits while attenuating response to fearful stimuli in visual and limbic regions. Self-ratings of intoxication correlated with striatal activation, suggesting that activation in this area may contribute to subjective experience of pleasure and reward during intoxication. These results show that the acute pharmacological rewarding and anxiolytic effects of alcohol can be measured with fMRI. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Gilman, Jodi M AU - Ramchandani, Vijay A AU - Davis, Megan B AU - Bjork, James M AU - Hommer, Daniel W AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA. gilmanj@mail.nih.gov Y1 - 2008/04/30/ PY - 2008 DA - 2008 Apr 30 SP - 4583 EP - 4591 VL - 28 IS - 18 KW - Alcohols KW - 0 KW - Anti-Anxiety Agents KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Facial Expression KW - Brain Mapping KW - Analysis of Variance KW - Oxygen -- blood KW - Humans KW - Linear Models KW - Adult KW - Surveys and Questionnaires KW - Male KW - Female KW - Photic Stimulation -- methods KW - Image Processing, Computer-Assisted -- methods KW - Magnetic Resonance Imaging KW - Alcoholic Intoxication -- pathology KW - Alcoholic Intoxication -- psychology KW - Anti-Anxiety Agents -- administration & dosage KW - Reward KW - Alcoholic Intoxication -- etiology KW - Alcohols -- administration & dosage KW - Alcoholic Intoxication -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69161970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Why+we+like+to+drink%3A+a+functional+magnetic+resonance+imaging+study+of+the+rewarding+and+anxiolytic+effects+of+alcohol.&rft.au=Gilman%2C+Jodi+M%3BRamchandani%2C+Vijay+A%3BDavis%2C+Megan+B%3BBjork%2C+James+M%3BHommer%2C+Daniel+W&rft.aulast=Gilman&rft.aufirst=Jodi&rft.date=2008-04-30&rft.volume=28&rft.issue=18&rft.spage=4583&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.0086-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Prog Neuropsychopharmacol Biol Psychiatry. 1993 Mar;17(2):171-82 [8094255] Cell Mol Neurobiol. 2003 Oct;23(4-5):727-38 [14514027] Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91 [8401595] Brain. 1995 Feb;118 ( Pt 1):279-306 [7895011] Psychopharmacology (Berl). 1995 Dec;122(4):369-73 [8657835] Comput Biomed Res. 1996 Jun;29(3):162-73 [8812068] J Neuropsychiatry Clin Neurosci. 1997 Summer;9(3):482-97 [9276849] Eur J Pharmacol. 2000 Mar 30;393(1-3):295-314 [10771025] Pharmacopsychiatry. 2003 Nov;36 Suppl 3:S191-4 [14677078] J Neurosci. 2004 Feb 25;24(8):1793-802 [14985419] JAMA. 2004 Mar 10;291(10):1238-45 [15010446] Neuropsychopharmacology. 2004 Aug;29(8):1527-37 [15085090] J Abnorm Psychol. 1980 Aug;89(4):528-38 [7400453] NIDA Res Monogr. 1986;67:209-14 [3092068] Alcohol Clin Exp Res. 1988 Feb;12(1):30-8 [3279857] J Pers Soc Psychol. 1988 Jun;54(6):1063-70 [3397865] Alcohol Clin Exp Res. 1990 Feb;14(1):63-70 [2178475] Neuroscience. 1990;35(3):669-74 [1974330] Trends Pharmacol Sci. 1992 May;13(5):177-84 [1604710] Neuron. 1997 Sep;19(3):591-611 [9331351] Neuroimage. 1997 Aug;6(2):93-103 [9299383] J Abnorm Psychol. 1997 Nov;106(4):598-607 [9358690] Alcohol Clin Exp Res. 1998 Feb;22(1):3-9 [9514280] Gastroenterology. 1998 Dec;115(6):1552-7 [9834284] Alcohol Clin Exp Res. 1998 Dec;22(9):1903-11 [9884132] Alcohol Clin Exp Res. 1999 Apr;23(4):617-23 [10235297] Life Sci. 2005 Jun 24;77(6):693-706 [15922000] Curr Opin Neurol. 2005 Aug;18(4):411-7 [16003117] Trends Cogn Sci. 2005 Dec;9(12):585-94 [16289871] Neurosci Biobehav Rev. 2006;30(2):215-38 [16099045] Neuroimage. 2006 May 1;30(4):1441-8 [16368249] Psychopharmacology (Berl). 2007 Apr;191(3):813-22 [17279377] Biol Psychiatry. 2007 Jun 1;61(11):1306-9 [17306772] Alcohol Clin Exp Res. 2007 Jul;31(7):1138-47 [17488322] Alcohol Clin Exp Res. 2007 Sep;31(9):1490-504 [17624997] Am J Psychiatry. 1998 Aug;155(8):1009-15 [9699686] Alcohol Clin Exp Res. 2000 Apr;24(4):426-7 [10798577] Alcohol Clin Exp Res. 2000 Jun;24(6):822-9 [10888070] J Neurosci. 2001 Apr 15;21(8):2793-8 [11306631] Alcohol Clin Exp Res. 2001 Apr;25(4):540-8 [11329494] J Neurosci. 2001 Aug 15;21(16):RC159 [11459880] Psychopharmacology (Berl). 2001 Aug;157(1):20-30 [11512039] J Clin Pharmacol. 2001 Dec;41(12):1345-50 [11762562] Nat Neurosci. 2002 Feb;5(2):97-8 [11802175] Neuron. 2002 Feb 28;33(5):815-26 [11879657] J Stud Alcohol. 2002 Jan;63(1):64-73 [11925061] J Neurosci. 2002 May 1;22(9):3312-20 [11978805] Health Psychol. 2002 May;21(3):229-36 [12027028] Alcohol Clin Exp Res. 2002 Jun;26(6):827-35 [12068251] Alcohol Clin Exp Res. 2002 Aug;26(8):1299-306 [12198408] Alcohol Clin Exp Res. 2002 Oct;26(10):1568-73 [12394291] J Stud Alcohol. 2002 Nov;63(6):734-44 [12529074] Synapse. 2003 Sep 15;49(4):226-31 [12827641] Trends Neurosci. 2003 Aug;26(8):423-8 [12900173] Biol Psychiatry. 2003 Sep 1;54(5):504-14 [12946879] Alcohol Clin Exp Res. 1993 Feb;17(1):140-6 [8452195] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1523/JNEUROSCI.0086-08.2008 ER - TY - JOUR T1 - Nucleotidylylation of the VPg protein of a human norovirus by its proteinase-polymerase precursor protein. AN - 70503632; 18234264 AB - Caliciviruses have a positive strand RNA genome covalently-linked at the 5'-end to a small protein, VPg. This study examined the biochemical modification of VPg by the ProPol form of the polymerase of human norovirus strain MD145 (GII.4). Recombinant norovirus VPg was shown to be nucleotidylylated in the presence of Mn2+ by MD145 ProPol. Phosphodiesterase I treatment of the nucleotidylylated VPg released the incorporated UMP, which was consistent with linkage of RNA to VPg via a phosphodiester bond. Mutagenesis analysis of VPg identified Tyrosine 27 as the target amino acid for this linkage, and suggested that VPg conformation was important for the reaction. Nucleotidylylation was inefficient in the presence of Mg2+; however the addition of full- and subgenomic-length MD145 RNA transcripts led to a marked enhancement of the nucleotidylylation efficiency in the presence of this divalent cation. Furthermore, evidence was found for the presence of an RNA element near the 3'-end of the polyadenylated genome that enhanced the efficiency of nucleotidylylation in the presence of Mg2+. JF - Virology AU - Belliot, Gaël AU - Sosnovtsev, Stanislav V AU - Chang, Kyeong-Ok AU - McPhie, Peter AU - Green, Kim Y AD - National Institutes of Health/DHHS, NIAID/LID, Building 50, Room 6316, 9000 Rockville Pike, Bethesda, MD 20892-8007, USA. gael.belliot@u-bourgogne.fr Y1 - 2008/04/25/ PY - 2008 DA - 2008 Apr 25 SP - 33 EP - 49 VL - 374 IS - 1 SN - 0042-6822, 0042-6822 KW - Coenzymes KW - 0 KW - Enzyme Activators KW - Gene Products, pol KW - RNA, Messenger KW - RNA, Viral KW - Recombinant Proteins KW - Viral Proteins KW - Tyrosine KW - 42HK56048U KW - Uridine Monophosphate KW - E2OU15WN0N KW - Phosphodiesterase I KW - EC 3.1.4.1 KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- isolation & purification KW - RNA, Messenger -- pharmacology KW - RNA, Viral -- pharmacology KW - Recombinant Proteins -- metabolism KW - Molecular Sequence Data KW - Magnesium -- pharmacology KW - Phosphodiesterase I -- metabolism KW - Amino Acid Sequence KW - Tyrosine -- metabolism KW - Coenzymes -- pharmacology KW - Enzyme Activators -- pharmacology KW - Viral Proteins -- genetics KW - Gene Products, pol -- isolation & purification KW - Uridine Monophosphate -- metabolism KW - Gene Products, pol -- metabolism KW - Viral Proteins -- chemistry KW - Viral Proteins -- metabolism KW - Norovirus -- metabolism KW - Norovirus -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70503632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Nucleotidylylation+of+the+VPg+protein+of+a+human+norovirus+by+its+proteinase-polymerase+precursor+protein.&rft.au=Belliot%2C+Ga%C3%ABl%3BSosnovtsev%2C+Stanislav+V%3BChang%2C+Kyeong-Ok%3BMcPhie%2C+Peter%3BGreen%2C+Kim+Y&rft.aulast=Belliot&rft.aufirst=Ga%C3%ABl&rft.date=2008-04-25&rft.volume=374&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2007.12.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO Rep. 2005 Oct;6(10):968-72 [16142217] J Virol. 2005 Apr;79(7):4012-24 [15767403] J Virol. 2006 Aug;80(15):7405-15 [16840321] J Virol. 2006 Aug;80(16):7816-31 [16873239] J Gen Virol. 2006 Sep;87(Pt 9):2621-30 [16894201] J Biol Chem. 2006 Sep 1;281(35):25315-25 [16835235] Virology. 2006 Sep 30;353(2):463-73 [16843517] Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11050-5 [17581883] J Gen Virol. 2007 Aug;88(Pt 8):2091-100 [17622609] J Virol. 2000 Nov;74(22):10359-70 [11044080] Virology. 2000 Nov 10;277(1):193-203 [11062050] J Virol. 2001 Feb;75(3):1211-9 [11152494] Virus Res. 2001 Mar;73(2):103-12 [11172914] Arch Virol. 2001;146(1):59-69 [11266218] J Biol Chem. 2001 Jul 27;276(30):27787-92 [11369764] J Clin Microbiol. 2001 Dec;39(12):4288-95 [11724834] J Infect Dis. 2002 Jan 15;185(2):133-46 [11807686] J Virol. 2002 Jul;76(14):7060-72 [12072506] EMBO J. 2003 Jun 2;22(11):2852-9 [12773399] J Virol. 2003 Oct;77(20):10957-74 [14512545] J Biol Chem. 2004 Mar 26;279(13):12659-67 [14711816] J Virol. 2004 Apr;78(8):3889-96 [15047805] J Biol Chem. 2004 Apr 16;279(16):16638-45 [14764591] J Virol. 2004 May;78(9):4931-5 [15078978] J Biol Chem. 2004 Sep 10;279(37):38103-10 [15218030] J Biol Chem. 1978 Aug 10;253(15):5263-6 [209034] Eur J Biochem. 1978 Dec 1;92(1):45-51 [215411] Proc Natl Acad Sci U S A. 1978 Oct;75(10):4868-72 [217003] Nucleic Acids Res. 1978 Dec;5(12):4505-22 [745988] Virology. 1990 Sep;178(1):285-8 [2202147] J Virol. 1991 Jan;65(1):511-3 [1702164] Science. 1993 Jan 22;259(5094):516-9 [8380940] Virology. 1993 Jul;195(1):51-61 [8391187] Virology. 1995 Jul 10;210(2):383-90 [7618275] Virology. 1996 May 1;219(1):1-8 [8623518] J Gen Virol. 1997 May;78 ( Pt 5):1033-40 [9152420] J Virol. 1998 May;72(5):4492-7 [9557747] Nature. 1998 May 21;393(6682):280-4 [9607767] J Virol. 2005 Feb;79(4):2393-403 [15681440] J Virol. 2006 Jul;80(14):7060-9 [16809311] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2007.12.028 ER - TY - CPAPER T1 - Prospective Study of NK Cell Phenotype in Recurrent HCV Infection after Liver Transplant. T2 - 43rd Annual Meeting of the European Association for the Study of the Liver AN - 40851083; 4818279 JF - 43rd Annual Meeting of the European Association for the Study of the Liver AU - Varchetta, S AU - Oliviero, B AU - Donato, F AU - Agnelli, F AU - Rossi, G AU - Rigamonti, C AU - Colombo, M AU - Paudice, E AU - Mavilio, D AU - Mondelli, M U Y1 - 2008/04/23/ PY - 2008 DA - 2008 Apr 23 KW - Infection KW - Liver KW - Recurrent infection KW - Natural killer cells KW - Transplants KW - Phenotypes KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40851083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=43rd+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.atitle=Prospective+Study+of+NK+Cell+Phenotype+in+Recurrent+HCV+Infection+after+Liver+Transplant.&rft.au=Varchetta%2C+S%3BOliviero%2C+B%3BDonato%2C+F%3BAgnelli%2C+F%3BRossi%2C+G%3BRigamonti%2C+C%3BColombo%2C+M%3BPaudice%2C+E%3BMavilio%2C+D%3BMondelli%2C+M+U&rft.aulast=Varchetta&rft.aufirst=S&rft.date=2008-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=43rd+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.issn=&rft_id=info:doi/ L2 - http://www.easl.ch/liver-meeting/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship of Hepatitis C Virus to Hepatocellular Carcinoma in Dialysis Patients. T2 - 43rd Annual Meeting of the European Association for the Study of the Liver AN - 40845819; 4818906 JF - 43rd Annual Meeting of the European Association for the Study of the Liver AU - Henderson, W A AU - Gill, J M AU - Kim, K H AU - Skanderson, M AU - Butt, A A Y1 - 2008/04/23/ PY - 2008 DA - 2008 Apr 23 KW - Hepatitis KW - Dialysis KW - Hepatocellular carcinoma KW - Tumors KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=43rd+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.atitle=Relationship+of+Hepatitis+C+Virus+to+Hepatocellular+Carcinoma+in+Dialysis+Patients.&rft.au=Henderson%2C+W+A%3BGill%2C+J+M%3BKim%2C+K+H%3BSkanderson%2C+M%3BButt%2C+A+A&rft.aulast=Henderson&rft.aufirst=W&rft.date=2008-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=43rd+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver&rft.issn=&rft_id=info:doi/ L2 - http://www.easl.ch/liver-meeting/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Subspecies Genetic Assignments of Worldwide Captive Tigers Increase Conservation Value of Captive Populations AN - 20765456; 8230913 AB - Tigers (Panthera tigris) are disappearing rapidly from the wild, from over 100,000 in the 1900s to as few as 3000. Javan (P.t. sondaica), Bali (P.t. balica), and Caspian (P.t. virgata) subspecies are extinct, whereas the South China tiger (P.t amoyensis) persists only in zoos. By contrast, captive tigers are flourishing, with 15,000-20,000 individuals worldwide, outnumbering their wild relatives five to seven times. We assessed subspecies genetic ancestry of 105 captive tigers from 14 countries and regions by using Bayesian analysis and diagnostic genetic markers defined by a prior analysis of 134 voucher tigers of significant genetic distinctiveness. We assigned 49 tigers to one of five subspecies (Bengal P.t. tigris, Sumatran P.t. sumatrae, Indochinese P.t. corbetti, Amur P.t. altaica, and Malayan P.t. jacksoni tigers) and determined 52 had admixed subspecies origins. The tested captive tigers retain appreciable genomic diversity unobserved in their wild counterparts, perhaps a consequence of large population size, century-long introduction of new founders, and managed-breeding strategies to retain genetic variability. Assessment of verified subspecies ancestry offers a powerful tool that, if applied to tigers of uncertain background, may considerably increase the number of purebred tigers suitable for conservation management. JF - Current Biology AU - Luo, S-J AU - Johnson, W E AU - Martenson, J AU - Antunes, A AU - Martelli, P AU - Uphyrkina, O AU - Traylor-Holzer, K AU - Smith, JLD AU - O'Brien, S J AD - Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA, obrien@ncifcrf.gov Y1 - 2008/04/22/ PY - 2008 DA - 2008 Apr 22 SP - 592 EP - 596 VL - 18 IS - 8 SN - 0960-9822, 0960-9822 KW - Ecology Abstracts; Genetics Abstracts KW - Bayesian analysis KW - Genetic markers KW - Conservation KW - genomics KW - Panthera tigris KW - D 04040:Ecosystem and Ecology Studies KW - G 07750:Ecological & Population Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20765456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Subspecies+Genetic+Assignments+of+Worldwide+Captive+Tigers+Increase+Conservation+Value+of+Captive+Populations&rft.au=Luo%2C+S-J%3BJohnson%2C+W+E%3BMartenson%2C+J%3BAntunes%2C+A%3BMartelli%2C+P%3BUphyrkina%2C+O%3BTraylor-Holzer%2C+K%3BSmith%2C+JLD%3BO%27Brien%2C+S+J&rft.aulast=Luo&rft.aufirst=S-J&rft.date=2008-04-22&rft.volume=18&rft.issue=8&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=Current+Biology&rft.issn=09609822&rft_id=info:doi/10.1016%2Fj.cub.2008.03.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bayesian analysis; Genetic markers; Conservation; genomics; Panthera tigris DO - http://dx.doi.org/10.1016/j.cub.2008.03.053 ER - TY - JOUR T1 - Tumour-necrosis factor-A polymorphisms and gastric cancer risk: a meta-analysis AN - 20729728; 8228552 AB - Inflammation is one of the early phases in the development of gastric cancer. Therefore, several studies have examined the association of polymorphisms in tumour-necrosis factor-A gene (TNF-A) with gastric cancer risk. This meta-analysis reviews and summarises published evidence for these associations. Searching several databases yielded 24 independent studies that reported on the associations between TNF-A polymorphisms and gastric cancer risk. We analysed available data for the most commonly investigated polymorphisms: TNF-A -308G>A (23 studies), TNF-A -238G>A (9 studies), and TNF-A -857C>T (5 studies). Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in the random-effects model using the DerSimonian-Laird method. Q-statistic and l super(2)-statistic were calculated to examine heterogeneity, and funnel plots were plotted to examine small study effects. The overall ORs (95% CIs) for AG and AA genotypes vs GG genotype for TNF-A -308 were 1.09 (0.94-1.27) and 1.49 (1. 11 -1.99), respectively. For TNF-A -238, the corresponding ORs (95% CIs) were 1.05 (0.84-1.33) and 1.25 (0.30-5.20, respectively. The overall ORs (95% CIs) for CT and TT genotypes (vs CC) for TNF-A -857 were 1.06 (0.89-1.27) and 1.57 (0.91 -2.70), respectively. The statistically significant association between TNF-A -308GG and gastric cancer was limited to western populations. This association showed little heterogeneity (l super(2) = 0) and remained consistently strong when analyses were limited to anatomic and histologic subtypes of gastric cancer, or limited to studies in which genotype frequencies were in Hardy-Weinberg equilibrium, or limited to larger studies. These same subgroup analyses did not change results associated with other polymorphisms. In conclusion, TNF-A -308AA genotype was associated with a statistically significant increased risk of gastric cancer, whereas other studied polymorphisms were not The association between TNF-A -857TT genotype and gastric cancer was near significant, and may become significant if more studies are published. JF - British Journal of Cancer AU - Gorouhi, F AU - Islami, F AU - Bahrami, H AU - Kamangar, F AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, A/ID, USA, kamangaf@mail.nih.gov Y1 - 2008/04/22/ PY - 2008 DA - 2008 Apr 22 SP - 1443 EP - 1451 VL - 98 IS - 8 SN - 0007-0920, 0007-0920 KW - Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Data processing KW - Gene polymorphism KW - Statistical analysis KW - Genotypes KW - Cancer KW - Models KW - Inflammation KW - Databases KW - Reviews KW - Tumor necrosis factor- alpha KW - Gastric cancer KW - B 26690:General, Reviews, Book Notices KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Tumour-necrosis+factor-A+polymorphisms+and+gastric+cancer+risk%3A+a+meta-analysis&rft.au=Gorouhi%2C+F%3BIslami%2C+F%3BBahrami%2C+H%3BKamangar%2C+F&rft.aulast=Gorouhi&rft.aufirst=F&rft.date=2008-04-22&rft.volume=98&rft.issue=8&rft.spage=1443&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604277 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Reviews; Gene polymorphism; Statistical analysis; Tumor necrosis factor- alpha; Gastric cancer; Inflammation; Models; Genotypes; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6604277 ER - TY - JOUR T1 - Estimation of low frequency antigen-presenting cells with a novel RELISPOT assay AN - 20904560; 8245880 AB - Adequate presentation of self and foreign antigens is a key factor for efficient T-cell immunosurveillance against pathogens and tumors. Cells presenting foreign antigens usually comprise a rare population and are difficult to detect even at the peak of infection. Here we demonstrate a CD8 super(+) T-cell-based approach that allows detection of specific antigen-presenting cells (APC) at a frequency of less than 0.0005%. When T cells are in excess, they form rosettes with rare APCs, which appear as single spots in an IFN- gamma ELISPOT assay. Using this RELISPOT (Rosette ELISPOT) method we demonstrate the dynamic interplay between CD8 T cells and professional and non-professional APCs following virus challenge. JF - Journal of Immunological Methods AU - Dzutsev, A K AU - Belyakov, I M AU - Isakov, D V AU - Gagnon, S J AU - Margulies, D H AU - Berzofsky, JA AD - CCR, NCI, NIH, Bethesda, MD, USA, berzofsk@helix.nih.gov Y1 - 2008/04/20/ PY - 2008 DA - 2008 Apr 20 SP - 71 EP - 78 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 333 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Rosette KW - gamma -Interferon KW - Enzyme-linked immunosorbent assay KW - Self KW - Tumors KW - Pathogens KW - CD8 antigen KW - Antigen presentation KW - Infection KW - Autoantigens KW - Immunosurveillance KW - adenomatous polyposis coli KW - Lymphocytes T KW - Antigen-presenting cells KW - V 22350:Immunology KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20904560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Estimation+of+low+frequency+antigen-presenting+cells+with+a+novel+RELISPOT+assay&rft.au=Dzutsev%2C+A+K%3BBelyakov%2C+I+M%3BIsakov%2C+D+V%3BGagnon%2C+S+J%3BMargulies%2C+D+H%3BBerzofsky%2C+JA&rft.aulast=Dzutsev&rft.aufirst=A&rft.date=2008-04-20&rft.volume=333&rft.issue=1-2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2008.01.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Rosette; gamma -Interferon; Enzyme-linked immunosorbent assay; Self; CD8 antigen; Pathogens; Tumors; Infection; Antigen presentation; Autoantigens; adenomatous polyposis coli; Immunosurveillance; Lymphocytes T; Antigen-presenting cells DO - http://dx.doi.org/10.1016/j.jim.2008.01.008 ER - TY - JOUR T1 - Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. AN - 70487482; 18263588 AB - C1 domains mediate the recognition and subsequent signaling response to diacylglycerol and phorbol esters by protein kinase C (PKC) and by several other families of signal-transducing proteins such as the chimerins or RasGRP. MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase), a member of the dystrophia myotonica protein kinase family that functions downstream of Cdc42, contains a C1 domain with substantial homology to that of the diacylglycerol/phorbol ester-responsive C1 domains and has been reported to bind phorbol ester. We have characterized here the interaction of the C1 domains of the two MRCK isoforms alpha and beta with phorbol ester. The MRCK C1 domains bind [20-(3)H]phorbol 12,13-dibutyrate with K(d) values of 10 and 17 nm, respectively, reflecting 60-90-fold weaker affinity compared with the protein kinase C delta C1b domain. In contrast to binding by the C1b domain of PKCdelta, the binding by the C1 domains of MRCK alpha and beta was fully dependent on the presence of phosphatidylserine. Comparison of ligand binding selectivity showed resemblance to that by the C1b domain of PKCalpha and marked contrast to that of the C1b domain of PKCdelta. In intact cells, as in the binding assays, the MRCK C1 domains required 50-100-fold higher concentrations of phorbol ester for induction of membrane translocation. We conclude that additional structural elements within the MRCK structure are necessary if the C1 domains of MRCK are to respond to phorbol ester at concentrations comparable with those that modulate PKC. JF - The Journal of biological chemistry AU - Choi, Sung Hee AU - Czifra, Gabriella AU - Kedei, Noemi AU - Lewin, Nancy E AU - Lazar, Jozsef AU - Pu, Yongmei AU - Marquez, Victor E AU - Blumberg, Peter M AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/04/18/ PY - 2008 DA - 2008 Apr 18 SP - 10543 EP - 10549 VL - 283 IS - 16 SN - 0021-9258, 0021-9258 KW - Phorbol Esters KW - 0 KW - Phosphatidylserines KW - CDC42BPA protein, human KW - EC 2.7.1.- KW - CDC42BPB protein, human KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Myotonin-Protein Kinase KW - EC 2.7.11.1 KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Escherichia coli -- metabolism KW - Humans KW - Biological Transport KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Protein Binding KW - Phosphatidylserines -- chemistry KW - Kinetics KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Protein Transport KW - Protein Conformation KW - Protein-Serine-Threonine Kinases -- chemistry KW - Phorbol Esters -- chemistry KW - Protein-Tyrosine Kinases -- physiology KW - Protein-Tyrosine Kinases -- chemistry KW - Protein-Serine-Threonine Kinases -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70487482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Characterization+of+the+interaction+of+phorbol+esters+with+the+C1+domain+of+MRCK+%28myotonic+dystrophy+kinase-related+Cdc42+binding+kinase%29+alpha%2Fbeta.&rft.au=Choi%2C+Sung+Hee%3BCzifra%2C+Gabriella%3BKedei%2C+Noemi%3BLewin%2C+Nancy+E%3BLazar%2C+Jozsef%3BPu%2C+Yongmei%3BMarquez%2C+Victor+E%3BBlumberg%2C+Peter+M&rft.aulast=Choi&rft.aufirst=Sung&rft.date=2008-04-18&rft.volume=283&rft.issue=16&rft.spage=10543&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M707463200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2001 Apr;21(8):2767-78 [11283256] J Biol Chem. 2006 Nov 3;281(44):33773-88 [16950780] J Cell Sci. 2002 Dec 1;115(Pt 23):4399-411 [12414987] Br J Pharmacol. 2003 Apr;138(7):1191-201 [12711617] Methods Mol Biol. 2003;233:129-56 [12840504] Trends Pharmacol Sci. 2003 Nov;24(11):602-8 [14607084] Cell Signal. 2004 Sep;16(9):983-9 [15212759] Bioorg Med Chem. 2004 Sep 1;12(17):4575-83 [15358285] Cell. 2004 Oct 29;119(3):407-18 [15507211] Cancer Res. 1977 Sep;37(9):3257-65 [195722] J Biol Chem. 1979 May 25;254(10):3692-5 [438153] J Cell Biochem. 1985;29(1):37-44 [4055921] J Biol Chem. 1994 Jul 29;269(30):19553-8 [7518459] J Biol Chem. 1995 May 5;270(18):10777-83 [7537738] Cell. 1995 Jun 16;81(6):917-24 [7781068] Protein Sci. 1997 Feb;6(2):477-80 [9041654] Mol Cell Biol. 1998 Jan;18(1):130-40 [9418861] Biochim Biophys Acta. 1998 Aug 21;1376(2):155-72 [9748550] Cell. 1998 Oct 30;95(3):307-18 [9814702] Biochim Biophys Acta. 1998 Dec 8;1436(1-2):117-26 [9838074] J Biol Chem. 2005 Apr 8;280(14):13205-8 [15701647] J Biol Chem. 2005 Jul 22;280(29):27329-38 [15923197] Growth Factors. 2005 Dec;23(4):245-52 [16338787] J Cell Biochem. 2006 Feb 15;97(3):474-84 [16288460] Methods Enzymol. 2006;407:82-98 [16757316] FASEB J. 2006 Jun;20(8):1142-51 [16770013] Trends Pharmacol Sci. 2006 Jun;27(6):317-23 [16678913] Biochim Biophys Acta. 2006 Jul;1761(7):633-54 [16809062] Biochim Biophys Acta. 2006 Aug;1761(8):827-37 [16861033] Biochem Soc Trans. 2006 Nov;34(Pt 5):855-7 [17052214] J Biol Chem. 2002 Jan 4;277(1):645-55 [11584014] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M707463200 ER - TY - JOUR T1 - Intensive Care for Extreme Prematurity -- Moving beyond Gestational Age AN - 223923804; 18420500 AB - Background Decisions regarding whether to administer intensive care to extremely premature infants are often based on gestational age alone. However, other factors also affect the prognosis for these patients. Methods We prospectively studied a cohort of 4446 infants born at 22 to 25 weeks' gestation (determined on the basis of the best obstetrical estimate) in the Neonatal Research Network of the National Institute of Child Health and Human Development to relate risk factors assessable at or before birth to the likelihood of survival, survival without profound neurodevelopmental impairment, and survival without neurodevelopmental impairment at a corrected age of 18 to 22 months. Results Among study infants, 3702 (83%) received intensive care in the form of mechanical ventilation. Among the 4192 study infants (94%) for whom outcomes were determined at 18 to 22 months, 49% died, 61% died or had profound impairment, and 73% died or had impairment. In multivariable analyses of infants who received intensive care, exposure to antenatal corticosteroids, female sex, singleton birth, and higher birth weight (per each 100-g increment) were each associated with reductions in the risk of death and the risk of death or profound or any neurodevelopmental impairment; these reductions were similar to those associated with a 1-week increase in gestational age. At the same estimated likelihood of a favorable outcome, girls were less likely than boys to receive intensive care. The outcomes for infants who underwent ventilation were better predicted with the use of the above factors than with use of gestational age alone. Conclusions The likelihood of a favorable outcome with intensive care can be better estimated by consideration of four factors in addition to gestational age: sex, exposure or nonexposure to antenatal corticosteroids, whether single or multiple birth, and birth weight. (ClinicalTrials.gov numbers, NCT00063063 and NCT00009633 .) JF - The New England Journal of Medicine AU - Tyson, Jon E, MD, MPH AU - Parikh, Nehal A, DO AU - Langer, John, MS AU - Green, Charles, PhD AU - Higgins, Rosemary D, MD Y1 - 2008/04/17/ PY - 2008 DA - 2008 Apr 17 SP - 1672 EP - 81 CY - Boston PB - Massachusetts Medical Society VL - 358 IS - 16 SN - 00284793 KW - Medical Sciences KW - Adrenal Cortex Hormones KW - Premature birth KW - Babies KW - Birth weight KW - Age KW - Ventilation KW - Menstruation KW - Hispanics KW - Intensive care KW - Birth Weight KW - Sex Factors KW - Disabled Children -- statistics & numerical data KW - Humans KW - Infant, Premature, Diseases -- mortality KW - Gestational Age KW - Prognosis KW - Infant, Newborn KW - Prenatal Care KW - Multivariate Analysis KW - Adrenal Cortex Hormones -- therapeutic use KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - Developmental Disabilities -- epidemiology KW - Female KW - Health Resources -- utilization KW - Male KW - Survival Analysis KW - Respiration, Artificial KW - Intensive Care, Neonatal KW - Infant, Premature, Diseases -- therapy KW - Outcome Assessment (Health Care) KW - Infant, Premature UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223923804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Intensive+Care+for+Extreme+Prematurity+--+Moving+beyond+Gestational+Age&rft.au=Tyson%2C+Jon+E%2C+MD%2C+MPH%3BParikh%2C+Nehal+A%2C+DO%3BLanger%2C+John%2C+MS%3BGreen%2C+Charles%2C+PhD%3BHiggins%2C+Rosemary+D%2C+MD&rft.aulast=Tyson&rft.aufirst=Jon&rft.date=2008-04-17&rft.volume=358&rft.issue=16&rft.spage=1672&rft.isbn=&rft.btitle=&rft.title=The+New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/10.1056%2FNEJMoa073059 LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2008 Massachusetts Medical Society. All rights reserved. N1 - Document feature - Tables; References N1 - Last updated - 2014-03-19 N1 - CODEN - NEJMAG DO - http://dx.doi.org/10.1056/NEJMoa073059 ER - TY - JOUR T1 - Human inter-individual variability in metabolism and genotoxic response to zidovudine. AN - 70490757; 18206198 AB - A mainstay of the antiretroviral drugs used for therapy of HIV-1, zidovudine (AZT) is genotoxic and becomes incorporated into DNA. Here we explored host inter-individual variability in AZT-DNA incorporation, by AZT radioimmunoassay (RIA), using 19 different strains of normal human mammary epithelial cells (NHMECs) exposed for 24 h to 200 microM AZT. Twelve of the 19 NHMEC strains showed detectable AZT-DNA incorporation levels (16 to 259 molecules of AZT/10(6) nucleotides), while 7 NHMEC strains did not show detectable AZT-DNA incorporation. In order to explore the basis for this variability, we compared the 2 NHMEC strains that showed the highest levels of AZT-DNA incorporation (H1 and H2) with 2 strains showing no detectable AZT-DNA incorporation (L1 and L2). All 4 strains had similar (> or =80%) cell survival, low levels of accumulation of cells in S-phase, and no relevant differences in response to the direct-acting mutagen bleomycin (BLM). Finally, when levels of thymidine kinase 1 (TK1), the first enzyme in the pathway for incorporation of AZT into DNA, were determined by Western blot analysis in all 19 NHMEC strains at 24 h of AZT exposure, higher TK1 protein levels were found in the 12 strains showing AZT-DNA incorporation, compared to the 7 showing no incorporation (p=0.0005, Mann-Whitney test). Furthermore, strains L1 and L2, which did not show AZT-DNA incorporation at 24 h, did have measurable incorporation by 48 and 72 h. These data suggest that variability in AZT-DNA incorporation may be modulated by inter-individual differences in the rate of induction of TK1 in response to AZT exposure. JF - Toxicology and applied pharmacology AU - Olivero, Ofelia A AU - Ming, Jessica M AU - Das, Shreyasi AU - Vazquez, Irma L AU - Richardson, Diana L AU - Weston, Ainsley AU - Poirier, Miriam C AD - Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892-4255, USA. oliveroo@exchange.nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 158 EP - 164 VL - 228 IS - 2 SN - 0041-008X, 0041-008X KW - Reverse Transcriptase Inhibitors KW - 0 KW - Bleomycin KW - 11056-06-7 KW - Zidovudine KW - 4B9XT59T7S KW - DNA KW - 9007-49-2 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - thymidine kinase 1 KW - Index Medicus KW - Reverse Transcriptase Inhibitors -- chemistry KW - Bleomycin -- pharmacology KW - Micronuclei, Chromosome-Defective -- drug effects KW - Mammary Glands, Human -- cytology KW - Reverse Transcriptase Inhibitors -- pharmacology KW - Humans KW - Mammary Glands, Human -- metabolism KW - Bleomycin -- metabolism KW - Thymidine Kinase -- metabolism KW - Interphase -- drug effects KW - Radioimmunoassay KW - Reverse Transcriptase Inhibitors -- metabolism KW - Blotting, Western KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Apoptosis -- drug effects KW - Bleomycin -- chemistry KW - Flow Cytometry KW - Time Factors KW - Mammary Glands, Human -- drug effects KW - Cell Cycle -- drug effects KW - Cell Line KW - Epithelial Cells -- metabolism KW - Epithelial Cells -- cytology KW - Epithelial Cells -- drug effects KW - Zidovudine -- metabolism KW - DNA -- metabolism KW - Zidovudine -- pharmacology KW - DNA -- chemistry KW - Zidovudine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70490757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Human+inter-individual+variability+in+metabolism+and+genotoxic+response+to+zidovudine.&rft.au=Olivero%2C+Ofelia+A%3BMing%2C+Jessica+M%3BDas%2C+Shreyasi%3BVazquez%2C+Irma+L%3BRichardson%2C+Diana+L%3BWeston%2C+Ainsley%3BPoirier%2C+Miriam+C&rft.aulast=Olivero&rft.aufirst=Ofelia&rft.date=2008-04-15&rft.volume=228&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-06 N1 - Date created - 2008-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 1999 Nov 15;161(1):82-99 [10558926] Toxicol Appl Pharmacol. 2008 Jan 15;226(2):206-11 [17949768] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):151-61 [15313587] Nucleic Acids Res. 1986 May 27;14(10):4381 [3012471] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] Nucleic Acids Res. 1987 Sep 11;15(17):7212 [2889186] Am J Obstet Gynecol. 1993 May;168(5):1510-6 [8098905] J Acquir Immune Defic Syndr. 1993 Dec;6(12):1287-96 [8254464] AIDS Res Hum Retroviruses. 1995 Jul;11(7):805-11 [7546907] J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;8(1):1-9 [8548339] Drug Metab Dispos. 1997 Apr;25(4):453-9 [9107545] J Natl Cancer Inst. 1997 Nov 5;89(21):1602-8 [9362158] N Engl J Med. 1997 Nov 20;337(21):1485-90 [9366579] Biochem Pharmacol. 1998 Aug 1;56(3):389-95 [9744577] J Infect Dis. 1998 Nov;178(5):1327-33 [9780252] AIDS. 1999 May 28;13(8):919-25 [10371172] Ann Pharmacother. 1999 Sep;33(9):989-95 [10492504] New Microbiol. 2004 Apr;27(2 Suppl 1):63-9 [15646066] Cancer Lett. 2005 Apr 28;221(2):201-11 [15808406] Mutagenesis. 2005 Mar;20(2):139-46 [15784690] Environ Mol Mutagen. 2007 Apr-May;48(3-4):215-23 [16395695] Environ Mol Mutagen. 2007 Apr-May;48(3-4):283-98 [17358026] Environ Mol Mutagen. 2007 Apr-May;48(3-4):330-43 [17358027] J Acquir Immune Defic Syndr. 2002 Apr 1;29(4):323-9 [11917235] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2007.12.005 ER - TY - JOUR T1 - Moderate doses of alcohol disrupt the functional organization of the human brain. AN - 70382096; 18280711 AB - Acute alcohol administration decreases overall brain glucose metabolism, which serves as a marker of brain activity. The behavioral effects of alcohol, however, are likely to reflect not only changes in regional brain activity but also the patterns of brain functional organization. Here we assessed the effects of a moderate dose of alcohol on the patterns of brain activity and cerebral differentiation. We measured brain glucose metabolism in 20 healthy controls with positron emission tomography and fluorodeoxyglucose during baseline and during alcohol intoxication (0.75 g/kg). We used the coefficient of variation (CV) to assess changes in brain metabolic homogeneity, which we used as a marker for cerebral differentiation. We found that alcohol decreased the CV in the brain and this effect was independent of the decrements in overall glucose metabolism. Our study revealed marked disruption in brain activity during alcohol intoxication including decreases in global and regional brain differentiation, a loss of right versus left brain metabolic laterality and a shift in the predominance of activity from cortical to limbic brain regions. The widespread nature of the changes induced by a moderate dose of alcohol is likely to contribute to the marked disruption of alcohol on behavior, mood, cognition and motor activity. JF - Psychiatry research AU - Volkow, Nora D AU - Ma, Yeming AU - Zhu, Wei AU - Fowler, Joanna S AU - Li, Juan AU - Rao, Manlong AU - Mueller, Klaus AU - Pradhan, Kith AU - Wong, Christopher AU - Wang, Gene-Jack AD - National Institute on Drug Abuse, 6001 Executive Blvd, Rockville, MD 20852, USA. Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 205 EP - 213 VL - 162 IS - 3 SN - 0165-1781, 0165-1781 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Alcoholic Intoxication -- diagnostic imaging KW - Positron-Emission Tomography KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Middle Aged KW - Glucose -- pharmacokinetics KW - Male KW - Glucose -- administration & dosage KW - Female KW - Alcoholic Intoxication -- metabolism KW - Functional Laterality -- drug effects KW - Ethanol -- adverse effects KW - Central Nervous System Depressants -- adverse effects KW - Brain -- drug effects KW - Ethanol -- administration & dosage KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Central Nervous System Depressants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70382096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Moderate+doses+of+alcohol+disrupt+the+functional+organization+of+the+human+brain.&rft.au=Volkow%2C+Nora+D%3BMa%2C+Yeming%3BZhu%2C+Wei%3BFowler%2C+Joanna+S%3BLi%2C+Juan%3BRao%2C+Manlong%3BMueller%2C+Klaus%3BPradhan%2C+Kith%3BWong%2C+Christopher%3BWang%2C+Gene-Jack&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2008-04-15&rft.volume=162&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/10.1016%2Fj.pscychresns.2007.04.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-03-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: NIDA Res Monogr. 1986;67:209-14 [3092068] Clin Chem. 1978 Oct;24(10):1724-9 [699277] Psychiatry Res. 1988 May;24(2):201-9 [3261427] J Stud Alcohol. 1990 Mar;51(2):114-22 [2308348] Psychiatry Res. 1990 Apr;35(1):39-48 [2164230] Alcohol Clin Exp Res. 1990 Jun;14(3):482-9 [2198826] Am J Psychiatry. 1994 Oct;151(10):1505-8 [8092344] J Cereb Blood Flow Metab. 1994 Nov;14(6):963-73 [7929660] J Stud Alcohol. 1994 Nov;55(6):645-56 [7861791] Brain. 1995 Dec;118 ( Pt 6):1437-46 [8595475] Neuron. 1997 Sep;19(3):591-611 [9331351] Alcohol Clin Exp Res. 1998 Feb;22(1):3-9 [9514280] J Stud Alcohol. 1998 May;59(3):258-69 [9598706] Am J Psychiatry. 1998 Aug;155(8):1009-15 [9699686] Psychiatry Res. 1998 Jun 30;82(3):135-46 [9754438] Alcohol Clin Exp Res. 2000 Jun;24(6):822-9 [10888070] Brain Lang. 2001 May;77(2):197-215 [11300704] Acta Physiol Scand. 2001 Jan;171(1):87-97 [11350267] Neuroimage. 2001 Aug;14(2):322-8 [11467906] Psychiatry Res. 2002 Feb 15;114(1):39-50 [11864808] J Cereb Blood Flow Metab. 1988 Aug;8(4):502-12 [3260593] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pscychresns.2007.04.010 ER - TY - JOUR T1 - Occupational exposure to pesticides and risk of adult brain tumors. AN - 69110886; 18299277 AB - The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three US hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. Using logistic regression models, the authors found no association between insecticide and herbicide exposures and risk for glioma and meningioma. There was no association between glioma and exposure to insecticides or herbicides, in men or women. Women who reported ever using herbicides had a significantly increased risk for meningioma compared with women who never used herbicides (odds ratio = 2.4, 95% confidence interval: 1.4, 4.3), and there were significant trends of increasing risk with increasing years of herbicide exposure (p = 0.01) and increasing cumulative exposure (p = 0.01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations. JF - American journal of epidemiology AU - Samanic, Claudine M AU - De Roos, Anneclaire J AU - Stewart, Patricia A AU - Rajaraman, Preetha AU - Waters, Martha A AU - Inskip, Peter D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. samanicc@mail.nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 976 EP - 985 VL - 167 IS - 8 KW - Pesticides KW - 0 KW - Index Medicus KW - Meningeal Neoplasms -- epidemiology KW - Meningioma -- epidemiology KW - Humans KW - Aged KW - Glioma -- epidemiology KW - Risk Assessment KW - Meningeal Neoplasms -- etiology KW - Meningioma -- etiology KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Glioma -- etiology KW - Incidence KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Brain Neoplasms -- epidemiology KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Pesticides -- toxicity KW - Brain Neoplasms -- etiology KW - Brain Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69110886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Occupational+exposure+to+pesticides+and+risk+of+adult+brain+tumors.&rft.au=Samanic%2C+Claudine+M%3BDe+Roos%2C+Anneclaire+J%3BStewart%2C+Patricia+A%3BRajaraman%2C+Preetha%3BWaters%2C+Martha+A%3BInskip%2C+Peter+D&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2008-04-15&rft.volume=167&rft.issue=8&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwm401 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2001 Jan 11;344(2):79-86 [11150357] Int J Cancer. 1999 Jul 19;82(2):155-60 [10389745] Int J Cancer. 2002 May 10;99(2):252-9 [11979441] Am J Ind Med. 2002 Sep;42(3):214-27 [12210690] Cancer Causes Control. 2003 Mar;14(2):139-50 [12749719] J Neurosurg. 2003 Nov;99(5):848-53 [14609164] Int J Cancer. 2005 Jan 1;113(1):116-25 [15386358] Bull World Health Organ. 1962;26:75-91 [13888659] Int J Cancer. 2005 May 1;114(5):797-805 [15609304] Environ Health Perspect. 2005 May;113(5):546-51 [15866761] Occup Environ Med. 2005 Nov;62(11):786-92 [16234405] Int J Cancer. 2006 Mar 1;118(5):1321-4 [16152609] Occup Environ Med. 2006 Apr;63(4):267-72 [16556747] Int J Cancer. 2006 Sep 1;119(5):1152-7 [16570277] Am J Epidemiol. 2006 Oct 1;164(7):629-36 [16835295] J Agric Saf Health. 2006 Nov;12(4):255-74 [17131948] Occup Environ Med. 2007 Aug;64(8):509-14 [17537748] Cancer. 2007 Aug 1;110(3):471-6 [17580362] Am J Ind Med. 2004 May;45(5):395-407 [15095422] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1583-8 [15466973] J Occup Med. 1979 Nov;21(11):745-8 [556268] Br J Ind Med. 1984 Feb;41(1):15-24 [6318800] Br J Cancer. 1985 Aug;52(2):259-70 [4027168] J Occup Med. 1986 Jul;28(7):497-501 [3734918] Scand J Work Environ Health. 1986 Oct;12(5):448-54 [3787216] Br J Ind Med. 1988 Feb;45(2):98-105 [3342201] J Occup Med. 1988 May;30(5):429-32 [3373347] Am J Epidemiol. 1988 Oct;128(4):778-85 [3421243] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] Arch Environ Health. 1991 Mar-Apr;46(2):110-6 [2006895] Lancet. 1991 Oct 26;338(8774):1027-32 [1681353] Cancer. 1992 May 15;69(10):2541-7 [1568177] Br J Ind Med. 1992 Apr;49(4):220-5 [1571291] Scand J Work Environ Health. 1992 Jun;18(3):201-4 [1615295] Neuroepidemiology. 1992;11(4-6):267-76 [1337947] Int J Epidemiol. 1993 Aug;22(4):579-83 [8225728] Cancer Causes Control. 1993 Nov;4(6):529-38 [8280830] J Occup Med. 1993 Dec;35(12):1208-12 [8113924] Epidemiol Rev. 1995;17(2):382-414 [8654518] Int J Epidemiol. 1996 Aug;25(4):744-52 [8921451] Int J Cancer. 1997 Jul 29;72(3):389-93 [9247278] Am J Ind Med. 1998 Sep;34(3):252-60 [9698994] Int J Cancer. 2002 Apr 1;98(4):609-15 [11920623] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwm401 ER - TY - JOUR T1 - Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. AN - 69109009; 18413775 AB - Gene-knockout studies in mice suggest that INHA, encoding a subunit of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal cell tumors. It is not known whether genetic variation in the inhibin pathway also influences susceptibility to testicular germ cell tumors (TGCT), the most common testicular cancer in young men. To address this question, we conducted a case-control analysis (577 cases; 707 controls) of single-nucleotide polymorphisms (SNP) in genes in the inhibin pathway among participants in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study. Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped. Odds ratios (OR) and 95% confidence intervals (CI) relating variant genotypes to TGCT risk were calculated using unconditional logistic regression. Among White subjects, an elevated risk of TGCT was observed for carriers of the T allele of the INHA variant rs2059693 (CT genotype: OR, 1.33; 95% CI, 1.04-1.71; TT: OR, 1.60; 95% CI, 1.01-2.52; P(trend) = 0.008). The association with rs2059693 was stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; CT: OR, 1.63; 95% CI, 0.89-2.99; TT: OR, 4.54; 95% CI 2.00-10.3; P(trend) = 0.0008). We found no evidence of association with variants in the other investigated genes. These findings suggest that genetic variation in the INHA locus influences TGCT development. JF - Cancer research AU - Purdue, Mark P AU - Graubard, Barry I AU - Chanock, Stephen J AU - Rubertone, Mark V AU - Erickson, Ralph L AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA. purduem@mail.nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 3043 EP - 3048 VL - 68 IS - 8 KW - Inhibins KW - 57285-09-3 KW - Index Medicus KW - Genotype KW - Animals KW - Risk Factors KW - Military Personnel KW - Humans KW - Case-Control Studies KW - Disease Models, Animal KW - Mice KW - United States -- epidemiology KW - Male KW - Inhibins -- genetics KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Neoplasms, Germ Cell and Embryonal -- epidemiology KW - Neoplasms, Germ Cell and Embryonal -- genetics KW - Testicular Neoplasms -- genetics KW - Testicular Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69109009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Genetic+variation+in+the+inhibin+pathway+and+risk+of+testicular+germ+cell+tumors.&rft.au=Purdue%2C+Mark+P%3BGraubard%2C+Barry+I%3BChanock%2C+Stephen+J%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L%3BMcGlynn%2C+Katherine+A&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2008-04-15&rft.volume=68&rft.issue=8&rft.spage=3043&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-07-5852 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Reprod. 2004 Aug;19(8):1760-4 [15205401] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Mol Cell Endocrinol. 2004 Oct 15;225(1-2):73-6 [15451570] J Obstet Gynaecol Br Commonw. 1973 Jul;80(7):651-3 [4723959] Acta Genet Med Gemellol (Roma). 1981;30(3):189-202 [6805197] Acta Genet Med Gemellol (Roma). 1984;33(1):131-9 [6429992] Cancer. 1989 Aug 15;64(4):956-61 [2545331] Br J Urol. 1990 Sep;66(3):315-7 [2119845] Nature. 1992 Nov 26;360(6402):313-9 [1448148] Eur Urol. 1993;23(1):54-9; discussion 60-1 [8477778] BMJ. 1994 May 28;308(6941):1393-9 [7912596] Cancer Causes Control. 1995 Nov;6(6):519-24 [8580300] Nature. 1996 Dec 5;384(6608):470-4 [8945475] Cancer. 1997 Sep 1;80(5):929-35 [9307193] Br J Cancer. 1997;76(9):1191-8 [9365168] Lancet. 1997 Dec 13;350(9093):1723-8 [9413462] J Clin Endocrinol Metab. 1998 Mar;83(3):969-75 [9506758] Mol Endocrinol. 1999 Jun;13(6):851-65 [10379885] Genet Epidemiol. 2005 Apr;28(3):261-72 [15637718] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Nat Genet. 2005 Dec;37(12):1320-2 [16258542] Ann N Y Acad Sci. 2005 Dec;1061:173-82 [16467266] Hum Genet. 2006 Aug;120(1):1-21 [16645853] Fertil Steril. 2007 Jan;87(1):210-2 [17084394] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):77-83 [17220333] Am J Epidemiol. 2007 Feb 15;165(4):355-63 [17110638] Dev Biol. 2000 Apr 15;220(2):225-37 [10753512] Nat Med. 2000 Jun;6(6):637-41 [10835679] Hum Reprod. 2000 Dec;15(12):2644-9 [11098038] Eur J Endocrinol. 2001 Dec;145(6):779-84 [11720904] Cancer Invest. 2001;19(8):842-53 [11768038] Mol Endocrinol. 2002 Feb;16(2):213-20 [11818495] Science. 2002 Jun 21;296(5576):2225-9 [12029063] Hum Reprod. 2002 Jul;17(7):1741-5 [12093833] Am J Public Health. 2002 Dec;92(12):1900-4 [12453804] Semin Reprod Med. 2004 Aug;22(3):177-85 [15319820] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-07-5852 ER - TY - JOUR T1 - IL-24 modulates IFN-g expression in patients with tuberculosis AN - 20896534; 8254207 AB - IL-24 is a newly described member of the IL-10 family. We previously demonstrated that PBMC from TB patients exhibited low levels of IL-24 and IFN-g compared to subjects with latent tuberculosis infection (LTBI). In order to investigate the role of IL-24 in IFN-g expression in TB patients, we stimulated PBMC from individuals with LTBI or TB patients with the Mtb-specific antigen, early secretory antigenic target-6 (ESAT-6) and measured cytokine expression using quantitative real-time PCR (qPCR). Exogenous IL-24 increased IFN-g expression in PBMC obtained from TB patients while neutralization of IL-24 reduced IFN-g expression in PBMC from subjects with LTBI. Exogenous IL-24 enhanced IFN-g expression by increasing expression of IL-12 family cytokines, including IL-12a, IL-12b, IL-23a and IL-27, and by reducing FOXP3 expression in PBMC from TB patients. This is the first demonstration that IL-24 may play an important role in IFN-g expression following infection with Mtb. JF - Immunology Letters AU - Wu, B AU - Huang, C AU - Kato-Maeda, M AU - Hopewell, P C AU - Daley, CL AU - Krensky, A M AU - Clayberger, C AD - Stanford University School of Medicine, Stanford, CA, United States, claybergerc@mail.nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 57 EP - 62 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 117 IS - 1 SN - 0165-2478, 0165-2478 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - g-Interferon KW - Mycobacterium KW - Infection KW - Interleukin 10 KW - Interleukin 24 KW - Interleukin 12 KW - Peripheral blood mononuclear cells KW - Foxp3 protein KW - Interleukin 27 KW - Polymerase chain reaction KW - Tuberculosis KW - ESAT-6 antigen KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20896534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology+Letters&rft.atitle=IL-24+modulates+IFN-g+expression+in+patients+with+tuberculosis&rft.au=Wu%2C+B%3BHuang%2C+C%3BKato-Maeda%2C+M%3BHopewell%2C+P+C%3BDaley%2C+CL%3BKrensky%2C+A+M%3BClayberger%2C+C&rft.aulast=Wu&rft.aufirst=B&rft.date=2008-04-15&rft.volume=117&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Immunology+Letters&rft.issn=01652478&rft_id=info:doi/10.1016%2Fj.imlet.2007.11.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 24; Interleukin 12; Peripheral blood mononuclear cells; g-Interferon; Foxp3 protein; Interleukin 27; Polymerase chain reaction; Tuberculosis; Infection; ESAT-6 antigen; Interleukin 10; Mycobacterium DO - http://dx.doi.org/10.1016/j.imlet.2007.11.018 ER - TY - JOUR T1 - The Research Agenda of the National Institute of Allergy and Infectious Diseases for Antimicrobial Resistance AN - 19742586; 8536906 AB - Antimicrobial resistance is an intrinsic and inevitable aspect of microbial survival that continually challenges human health. Research on antimicrobial resistance is central to the mission of the National Institute of Allergy and Infectious Diseases (NIAID). In fiscal year 2007, NIAID invested more than $800 million to support basic and translational research on antimicrobials, more than $200 million of which is devoted to understanding the causes, consequences, and treatments of antimicrobial drug resistance. The complex process that facilitates the transformation of ideas into therapies requires a pipeline that runs from bench to bedside, and NIAID has leveraged the entire spectrum of conventional and biodefense resources. NIAID works in partnership with other federal agencies, industry, foundation partners, and foreign governments. The basic and clinical research supported by NIAID will, ideally, continue to yield profound rewards in terms of the understanding, diagnosis, and treatment of infectious diseases. JF - Journal of Infectious Diseases AU - Peters, N K AU - Dixon, D M AU - Holland, S M AU - Fauci, A S AD - Program Officer for Antibacterial Resistance, National Institute of Allergy and Infectious Diseases, 610 Rockledge Dr., MSC 6603, Bethesda, MD 20892-S603, USA, kent.peters@nih.gov Y1 - 2008/04/15/ PY - 2008 DA - 2008 Apr 15 SP - 1087 EP - 1093 VL - 197 IS - 8 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Transformation KW - Translation KW - Hypersensitivity KW - Infectious diseases KW - Drug resistance KW - Reinforcement KW - Survival KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19742586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=The+Research+Agenda+of+the+National+Institute+of+Allergy+and+Infectious+Diseases+for+Antimicrobial+Resistance&rft.au=Peters%2C+N+K%3BDixon%2C+D+M%3BHolland%2C+S+M%3BFauci%2C+A+S&rft.aulast=Peters&rft.aufirst=N&rft.date=2008-04-15&rft.volume=197&rft.issue=8&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2FS33451 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transformation; Translation; Hypersensitivity; Infectious diseases; Drug resistance; Reinforcement; Survival DO - http://dx.doi.org/10.1086/S33451 ER - TY - CPAPER T1 - The HIV-1 Vpu Accessory Protein Hijacks the p97-Ufd1-Npl4 Endoplasmic Reticulum-Associated Degradation Pathway to Mediate Down-Regulation of CD4 Receptor Molecules T2 - 2008 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (D6) AN - 40825318; 4802712 JF - 2008 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (D6) AU - Magadan, Javier Guillermo Y1 - 2008/04/13/ PY - 2008 DA - 2008 Apr 13 KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28D6%29&rft.atitle=The+HIV-1+Vpu+Accessory+Protein+Hijacks+the+p97-Ufd1-Npl4+Endoplasmic+Reticulum-Associated+Degradation+Pathway+to+Mediate+Down-Regulation+of+CD4+Receptor+Molecules&rft.au=Magadan%2C+Javier+Guillermo&rft.aulast=Magadan&rft.aufirst=Javier&rft.date=2008-04-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28D6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 5&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppression of the Innate Immune Response by NSP1 during Rotavirus Infection T2 - 2008 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (D6) AN - 40825268; 4802711 JF - 2008 Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis (D6) AU - Arnold, Michelle Y1 - 2008/04/13/ PY - 2008 DA - 2008 Apr 13 KW - Immune response KW - Infection KW - Immunity KW - Defense mechanisms KW - Rotavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28D6%29&rft.atitle=Suppression+of+the+Innate+Immune+Response+by+NSP1+during+Rotavirus+Infection&rft.au=Arnold%2C+Michelle&rft.aulast=Arnold&rft.aufirst=Michelle&rft.date=2008-04-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Cell+Biology+of+Virus+Entry%2C+Replication+and+Pathogenesis+%28D6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 5&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Over-Expression of MAP3K8 Leads to an Invasive and Metastasis Prone Phenotype. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40878480; 4824491 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Pandey, Jyotsna AU - Dempsey, Jamie AU - Clark, Adam AU - Simmons, John AU - Shan, Zhihong AU - Wiest, Jonathan S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Metastases KW - Overexpression KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40878480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Over-Expression+of+MAP3K8+Leads+to+an+Invasive+and+Metastasis+Prone+Phenotype.&rft.au=Pandey%2C+Jyotsna%3BDempsey%2C+Jamie%3BClark%2C+Adam%3BSimmons%2C+John%3BShan%2C+Zhihong%3BWiest%2C+Jonathan+S&rft.aulast=Pandey&rft.aufirst=Jyotsna&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time Dependence of Hedgehog Signaling and Stem Cell Fraction in Pancreatic Cancer Cell Lines and Xenografts after Exposure to Ionizing Radiation. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40876750; 4824347 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Asano, Hiroaki AU - Chung, Eun Joo S AU - Brown, Aaron P AU - Scott, Tamalee AU - Citrin, Deborah E Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pancreatic cancer KW - Ionizing radiation KW - Stem cells KW - Xenografts KW - Signal transduction KW - Tumor cell lines KW - Hedgehog protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40876750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Time+Dependence+of+Hedgehog+Signaling+and+Stem+Cell+Fraction+in+Pancreatic+Cancer+Cell+Lines+and+Xenografts+after+Exposure+to+Ionizing+Radiation.&rft.au=Asano%2C+Hiroaki%3BChung%2C+Eun+Joo+S%3BBrown%2C+Aaron+P%3BScott%2C+Tamalee%3BCitrin%2C+Deborah+E&rft.aulast=Asano&rft.aufirst=Hiroaki&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The MYCN Oncogene is a Direct Target of miR-34a. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873735; 4824540 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wei, Jun S AU - Song, Young K AU - Durinck, Steffen AU - Chen, Qing-Rong AU - Cheuk, Adam Tai Chi AU - Zhang, Quangeng AU - Thiele, Carol J AU - Slack, Andrew AU - Shohet, Jason AU - Khan, Javed Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Oncogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+MYCN+Oncogene+is+a+Direct+Target+of+miR-34a.&rft.au=Wei%2C+Jun+S%3BSong%2C+Young+K%3BDurinck%2C+Steffen%3BChen%2C+Qing-Rong%3BCheuk%2C+Adam+Tai+Chi%3BZhang%2C+Quangeng%3BThiele%2C+Carol+J%3BSlack%2C+Andrew%3BShohet%2C+Jason%3BKhan%2C+Javed&rft.aulast=Wei&rft.aufirst=Jun&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - microRNA-7 is a Putative Tumor Suppressor in Glioblastoma Inhibiting Both EGFR and the Akt Pathway. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873716; 4824517 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kefas, Benjamin AU - Godlewski, Jakub AU - Comeau, Laurey AU - Li, Yunqing AU - Abounader, Roger AU - Lee, Jeongwu AU - Fine, Howard A AU - Chiocca, E Antonio AU - Lawler, Sean AU - Purow, Benjamin Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Glioblastoma KW - AKT protein KW - Epidermal growth factor receptors KW - Tumor suppressor genes KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=microRNA-7+is+a+Putative+Tumor+Suppressor+in+Glioblastoma+Inhibiting+Both+EGFR+and+the+Akt+Pathway.&rft.au=Kefas%2C+Benjamin%3BGodlewski%2C+Jakub%3BComeau%2C+Laurey%3BLi%2C+Yunqing%3BAbounader%2C+Roger%3BLee%2C+Jeongwu%3BFine%2C+Howard+A%3BChiocca%2C+E+Antonio%3BLawler%2C+Sean%3BPurow%2C+Benjamin&rft.aulast=Kefas&rft.aufirst=Benjamin&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Study of the Organization of the Mouse Mirome with an Analysis of the Expression and Functional Roles of a Cluster of miRNAs on Mouse Chromosome 15. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873655; 4824509 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Huppi, Konrad AU - Wahlberg, Brady AU - Volfovsky, Natalia AU - Cruz, Leigh-Ann AU - Patel, Ravi AU - Martin, Scott E AU - Jones, Tamara L AU - Gehlhaus, Kristen AU - Mackiewicz, Mark AU - Stephens, Robert AU - Mushinski, J Frederic AU - Caplen, Natasha J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Chromosomes KW - MiRNA KW - Chromosome 15 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+Study+of+the+Organization+of+the+Mouse+Mirome+with+an+Analysis+of+the+Expression+and+Functional+Roles+of+a+Cluster+of+miRNAs+on+Mouse+Chromosome+15.&rft.au=Huppi%2C+Konrad%3BWahlberg%2C+Brady%3BVolfovsky%2C+Natalia%3BCruz%2C+Leigh-Ann%3BPatel%2C+Ravi%3BMartin%2C+Scott+E%3BJones%2C+Tamara+L%3BGehlhaus%2C+Kristen%3BMackiewicz%2C+Mark%3BStephens%2C+Robert%3BMushinski%2C+J+Frederic%3BCaplen%2C+Natasha+J&rft.aulast=Huppi&rft.aufirst=Konrad&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ERK Activation Results in Sustained TGF-Beta Signaling by Preventing Ligand-Induced Type II Receptor Degradation in a Human B Cell Lymphoma Cell Line. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873382; 4824617 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Chen, Gang AU - Ghosh, Paritosh AU - Longo, Dan L Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lymphoma KW - Signal transduction KW - Tumor cell lines KW - B-cell lymphoma KW - Transforming growth factor-b KW - Cell activation KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=ERK+Activation+Results+in+Sustained+TGF-Beta+Signaling+by+Preventing+Ligand-Induced+Type+II+Receptor+Degradation+in+a+Human+B+Cell+Lymphoma+Cell+Line.&rft.au=Chen%2C+Gang%3BGhosh%2C+Paritosh%3BLongo%2C+Dan+L&rft.aulast=Chen&rft.aufirst=Gang&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discovery and Validation of Astrocytoma Biomarkers using Microdissected Tissue Specimens Coupled with Targeted and Mass Spectrometry-Based Proteomic Studies. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873062; 4824403 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wang, Weijie AU - Xu, Haifeng AU - Zhuang, Zhengping AU - Weil, Robert J AU - Lee, Cheng S AU - Balgley, Brian M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Bioindicators KW - Proteomics KW - Astrocytoma KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Discovery+and+Validation+of+Astrocytoma+Biomarkers+using+Microdissected+Tissue+Specimens+Coupled+with+Targeted+and+Mass+Spectrometry-Based+Proteomic+Studies.&rft.au=Wang%2C+Weijie%3BXu%2C+Haifeng%3BZhuang%2C+Zhengping%3BWeil%2C+Robert+J%3BLee%2C+Cheng+S%3BBalgley%2C+Brian+M&rft.aulast=Wang&rft.aufirst=Weijie&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D Np63a Alters Keratinocyte Growth Regulation via the Activation of the NF-a B Subunit c-Rel. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873047; 4824500 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - King, Kathryn E AU - Ponnamperuma, Roshini M AU - Allen, Clint AU - Chen, Zhong AU - Van Waes, Carter AU - Weinberg, Wendy C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Keratinocytes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=D+Np63a+Alters+Keratinocyte+Growth+Regulation+via+the+Activation+of+the+NF-a+B+Subunit+c-Rel.&rft.au=King%2C+Kathryn+E%3BPonnamperuma%2C+Roshini+M%3BAllen%2C+Clint%3BChen%2C+Zhong%3BVan+Waes%2C+Carter%3BWeinberg%2C+Wendy+C&rft.aulast=King&rft.aufirst=Kathryn&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Akt1 and Akt2 may Mediate Malignant Function in GBM. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40872994; 4824456 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Joy, Anna M AU - Smirnov, Ivan AU - Nakada, Mitsitoshi AU - Seif-Naraghi, Sonya AU - Rennert, Jessica AU - Beaudry, Christian AU - Sasse, Jeanne AU - Zenklusen, John AU - Fine, Howard AU - Berens, Michael AU - Feuerstein, Burt Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - AKT1 protein KW - AKT2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40872994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Akt1+and+Akt2+may+Mediate+Malignant+Function+in+GBM.&rft.au=Joy%2C+Anna+M%3BSmirnov%2C+Ivan%3BNakada%2C+Mitsitoshi%3BSeif-Naraghi%2C+Sonya%3BRennert%2C+Jessica%3BBeaudry%2C+Christian%3BSasse%2C+Jeanne%3BZenklusen%2C+John%3BFine%2C+Howard%3BBerens%2C+Michael%3BFeuerstein%2C+Burt&rft.aulast=Joy&rft.aufirst=Anna&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of PDCD4 Tumor Suppressor Protein is Regulated Negatively by PI3K/Akt/mTOR and Positively PKC d Pathways in Breast Cancer Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40872970; 4824454 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Akar, Ugur AU - Ozpolat, Bulent AU - Colburn, Nancy AU - Yang, Hsin-Sheng AU - Berestein, Gabriel Lopez AU - Arun, Banu Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - 1-Phosphatidylinositol 3-kinase KW - AKT protein KW - Tumor suppressor genes KW - Protein kinase C KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40872970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Expression+of+PDCD4+Tumor+Suppressor+Protein+is+Regulated+Negatively+by+PI3K%2FAkt%2FmTOR+and+Positively+PKC+d+Pathways+in+Breast+Cancer+Cells.&rft.au=Akar%2C+Ugur%3BOzpolat%2C+Bulent%3BColburn%2C+Nancy%3BYang%2C+Hsin-Sheng%3BBerestein%2C+Gabriel+Lopez%3BArun%2C+Banu&rft.aulast=Akar&rft.aufirst=Ugur&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The T-Box Transcription Factor Brachyury Controls Tumor Cell Migration and Invasion. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40872715; 4824377 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Fernando, Romaine I AU - Trono, Paola AU - Litzinger, Mary AU - Schlom, Jeffrey AU - Palena, Claudia Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Tumor cells KW - Cell migration KW - Transcription factors KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40872715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+T-Box+Transcription+Factor+Brachyury+Controls+Tumor+Cell+Migration+and+Invasion.&rft.au=Fernando%2C+Romaine+I%3BTrono%2C+Paola%3BLitzinger%2C+Mary%3BSchlom%2C+Jeffrey%3BPalena%2C+Claudia&rft.aulast=Fernando&rft.aufirst=Romaine&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Analysis of Azurin p28, an Anti-Tumor Peptide: Serum Stability and Mouse Pharmacokinetics. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40871961; 4824158 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gorman, Greg AU - Coward, Lori AU - Kerstner-Wood, Corenna AU - Freeman, Lea AU - Noker, Pat AU - Beattie, Craig AU - Gupta, Tapas Das AU - Jia, Lee Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pharmacokinetics KW - Azurin KW - Peptides KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40871961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Quantitative+Analysis+of+Azurin+p28%2C+an+Anti-Tumor+Peptide%3A+Serum+Stability+and+Mouse+Pharmacokinetics.&rft.au=Gorman%2C+Greg%3BCoward%2C+Lori%3BKerstner-Wood%2C+Corenna%3BFreeman%2C+Lea%3BNoker%2C+Pat%3BBeattie%2C+Craig%3BGupta%2C+Tapas+Das%3BJia%2C+Lee&rft.aulast=Gorman&rft.aufirst=Greg&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Knockdown of Smad6 Inhibits Cell Proliferation and Induces Apoptosis by Disturbing TGF-ss Homeostasis in Lung Cancer Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40871767; 4823075 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Jeon, Hyo-sung AU - Dracheva, Tatiana AU - Yang, Sei-Hoon AU - Meerzaman, Daoud AU - Jen, Jin Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Cell proliferation KW - Apoptosis KW - Homeostasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40871767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Knockdown+of+Smad6+Inhibits+Cell+Proliferation+and+Induces+Apoptosis+by+Disturbing+TGF-ss+Homeostasis+in+Lung+Cancer+Cells.&rft.au=Jeon%2C+Hyo-sung%3BDracheva%2C+Tatiana%3BYang%2C+Sei-Hoon%3BMeerzaman%2C+Daoud%3BJen%2C+Jin&rft.aulast=Jeon&rft.aufirst=Hyo-sung&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Concurrent Upregulation of the K-Ras 4A Splice Variant and Superoxide in Human Lung Adenocarcinoma Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40871641; 4824480 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gupta, Meghana B AU - Maciag, Anna AU - Anderson, Lucy M AU - Shiao, Yih-Horng Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung KW - Alternative splicing KW - K-Ras protein KW - Adenocarcinoma KW - Superoxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40871641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Concurrent+Upregulation+of+the+K-Ras+4A+Splice+Variant+and+Superoxide+in+Human+Lung+Adenocarcinoma+Cells.&rft.au=Gupta%2C+Meghana+B%3BMaciag%2C+Anna%3BAnderson%2C+Lucy+M%3BShiao%2C+Yih-Horng&rft.aulast=Gupta&rft.aufirst=Meghana&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Profile of BRCA1 and BRCA2 Tumor Biopsies from Chilean Patients with Hereditary Breast Cancer: An Array-CGH Approach T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40871523; 4821018 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Alvarez, Carolina AU - Tapia, Teresa AU - Solis, Luisa AU - Corvalan, Alejandro AU - Rozenblum, Ester AU - Munroe, David AU - Carvallo, Pilar Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - Biopsy KW - Tumors KW - Genomics KW - BRCA2 protein KW - BRCA1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40871523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genomic+Profile+of+BRCA1+and+BRCA2+Tumor+Biopsies+from+Chilean+Patients+with+Hereditary+Breast+Cancer%3A+An+Array-CGH+Approach&rft.au=Alvarez%2C+Carolina%3BTapia%2C+Teresa%3BSolis%2C+Luisa%3BCorvalan%2C+Alejandro%3BRozenblum%2C+Ester%3BMunroe%2C+David%3BCarvallo%2C+Pilar&rft.aulast=Alvarez&rft.aufirst=Carolina&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel FLCN Interacting Protein, FNIP2 T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40870974; 4821087 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Hasumi, Hisashi AU - Baba, Masaya AU - Hong, Seung-Beom AU - Hasumi, Yukiko AU - Linehan, W Marston AU - Schmidt, Laura S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40870974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Identification+of+a+Novel+FLCN+Interacting+Protein%2C+FNIP2&rft.au=Hasumi%2C+Hisashi%3BBaba%2C+Masaya%3BHong%2C+Seung-Beom%3BHasumi%2C+Yukiko%3BLinehan%2C+W+Marston%3BSchmidt%2C+Laura+S&rft.aulast=Hasumi&rft.aufirst=Hisashi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Constitutive Activation of the Epidermal Growth Factor Receptor (EGFR) in Non-Small Cell Lung Cancer Cells Bearing EGFR Mutation and Amplification. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40870835; 4823073 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Okabe, Takafumi AU - Okamoto, Isamu AU - Tamura, Kenji AU - Terashima, Masaaki AU - Yoshida, Takeshi AU - Satoh, Taroh AU - Takada, Minoru AU - Fukuoka, Masahiro AU - Nakagawa, Kazuhiko Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Mutation KW - Lung cancer KW - Growth factors KW - Epidermal growth factor receptors KW - Non-small cell lung carcinoma KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40870835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Differential+Constitutive+Activation+of+the+Epidermal+Growth+Factor+Receptor+%28EGFR%29+in+Non-Small+Cell+Lung+Cancer+Cells+Bearing+EGFR+Mutation+and+Amplification.&rft.au=Okabe%2C+Takafumi%3BOkamoto%2C+Isamu%3BTamura%2C+Kenji%3BTerashima%2C+Masaaki%3BYoshida%2C+Takeshi%3BSatoh%2C+Taroh%3BTakada%2C+Minoru%3BFukuoka%2C+Masahiro%3BNakagawa%2C+Kazuhiko&rft.aulast=Okabe&rft.aufirst=Takafumi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mitogenic Signaling Molecules Associated with the Effectiveness of Gefitinib (Iressa) in Treating Mammary Cancers in Rats. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40870665; 4823096 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Bode, Ann M AU - Grubbs, Clinton J AU - Lubet, Ronald A AU - Ericson, Marna E Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Rats KW - Signal transduction KW - Gefitinib KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40870665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Mitogenic+Signaling+Molecules+Associated+with+the+Effectiveness+of+Gefitinib+%28Iressa%29+in+Treating+Mammary+Cancers+in+Rats.&rft.au=Bode%2C+Ann+M%3BGrubbs%2C+Clinton+J%3BLubet%2C+Ronald+A%3BEricson%2C+Marna+E&rft.aulast=Bode&rft.aufirst=Ann&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNp63 is Differentially Expressed in Association with p53 Status and Regulates a Broad Program of Gene Expression in Head and Neck Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40870653; 4821043 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Yang, Xin-Ping AU - Friedman, Jay AU - Lu, Hai AU - Yan, Bin AU - Duggal, Praveen AU - Yeh, Ning T AU - Nottingham, Liesl AU - Chen, Zhong AU - Van Waes, Carter Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Head and neck cancer KW - Gene expression KW - P53 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40870653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=DNp63+is+Differentially+Expressed+in+Association+with+p53+Status+and+Regulates+a+Broad+Program+of+Gene+Expression+in+Head+and+Neck+Cancer&rft.au=Yang%2C+Xin-Ping%3BFriedman%2C+Jay%3BLu%2C+Hai%3BYan%2C+Bin%3BDuggal%2C+Praveen%3BYeh%2C+Ning+T%3BNottingham%2C+Liesl%3BChen%2C+Zhong%3BVan+Waes%2C+Carter&rft.aulast=Yang&rft.aufirst=Xin-Ping&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - WNT16, a New Biomarker of Senescence Involved in Lung Tumorigenesis T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40870601; 4821007 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Binet, Romuald AU - Ythier, Damien AU - Nissou, Damien AU - Brambilla, Christian AU - Brambilla, Elisabeth AU - Harris, Curtis C AU - Pedeux, Remy Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Bioindicators KW - Lung KW - Senescence KW - Tumorigenesis KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40870601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=WNT16%2C+a+New+Biomarker+of+Senescence+Involved+in+Lung+Tumorigenesis&rft.au=Binet%2C+Romuald%3BYthier%2C+Damien%3BNissou%2C+Damien%3BBrambilla%2C+Christian%3BBrambilla%2C+Elisabeth%3BHarris%2C+Curtis+C%3BPedeux%2C+Remy&rft.aulast=Binet&rft.aufirst=Romuald&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Array-based Outcome Predictors for Neuroblastoma T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40869297; 4821129 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Chen, Qing-Rong AU - Wei, Jun S AU - Wen, Xinyu AU - Asgharzadeh, Shahab AU - Seeger, Robert AU - Oberthuer, Andre AU - Berthold, Frank AU - Khan, Javed Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Neuroblastoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40869297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Evaluation+of+Array-based+Outcome+Predictors+for+Neuroblastoma&rft.au=Chen%2C+Qing-Rong%3BWei%2C+Jun+S%3BWen%2C+Xinyu%3BAsgharzadeh%2C+Shahab%3BSeeger%2C+Robert%3BOberthuer%2C+Andre%3BBerthold%2C+Frank%3BKhan%2C+Javed&rft.aulast=Chen&rft.aufirst=Qing-Rong&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ABCB1 Genetic Variation Influences the Toxicity and Clinical Outcome of Patients Treated with Docetaxel. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867986; 4824159 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Sissung, Tristan M AU - Baum, Caitlin E AU - Deeken, John AU - Price, Douglas K AU - Steinberg, Seth M AU - Dahut, William AU - Sparreboom, Alex AU - Figg, William D Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Toxicity KW - Genetic diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=ABCB1+Genetic+Variation+Influences+the+Toxicity+and+Clinical+Outcome+of+Patients+Treated+with+Docetaxel.&rft.au=Sissung%2C+Tristan+M%3BBaum%2C+Caitlin+E%3BDeeken%2C+John%3BPrice%2C+Douglas+K%3BSteinberg%2C+Seth+M%3BDahut%2C+William%3BSparreboom%2C+Alex%3BFigg%2C+William+D&rft.aulast=Sissung&rft.aufirst=Tristan&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PDGFss Dependent Activation of MAPK through the PDGFss Receptor and G Protein-Coupled Receptor Involves Syk and Gab in Peripheral Lung Epithelial Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867837; 4823083 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Sithanandam, Gunamani AU - Fornwald, Laura W AU - Anderson, Lucy M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung KW - Syk protein KW - MAP kinase KW - Epithelial cells KW - G protein-coupled receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=PDGFss+Dependent+Activation+of+MAPK+through+the+PDGFss+Receptor+and+G+Protein-Coupled+Receptor+Involves+Syk+and+Gab+in+Peripheral+Lung+Epithelial+Cells.&rft.au=Sithanandam%2C+Gunamani%3BFornwald%2C+Laura+W%3BAnderson%2C+Lucy+M&rft.aulast=Sithanandam&rft.aufirst=Gunamani&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of RhoA Associated Signaling by Lovastatin and Celecoxib in Human Colon Cancer Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867625; 4822852 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Guruswamy, Suresh AU - Steele, Vernon E AU - Kopelovich, Levy AU - Rao, Chinthalapally V Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colon cancer KW - Signal transduction KW - RhoA protein KW - Lovastatin KW - Celecoxib KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Modulation+of+RhoA+Associated+Signaling+by+Lovastatin+and+Celecoxib+in+Human+Colon+Cancer+Cells.&rft.au=Guruswamy%2C+Suresh%3BSteele%2C+Vernon+E%3BKopelovich%2C+Levy%3BRao%2C+Chinthalapally+V&rft.aulast=Guruswamy&rft.aufirst=Suresh&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Real-Time Monitoring of Cancer Cell Viability using a Molecularly Targeted pH-Activatable Fluorescent Imaging Probe. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867523; 4824323 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kobayashi, Hisataka AU - Hama, Yukihiro AU - Koyama, Yoshinori AU - Choyke, Peter L AU - Asanuma, Daisuke AU - Nagano, Tetuo AU - Urano, Yasuteru Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Fluorescent indicators KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=In+Vivo+Real-Time+Monitoring+of+Cancer+Cell+Viability+using+a+Molecularly+Targeted+pH-Activatable+Fluorescent+Imaging+Probe.&rft.au=Kobayashi%2C+Hisataka%3BHama%2C+Yukihiro%3BKoyama%2C+Yoshinori%3BChoyke%2C+Peter+L%3BAsanuma%2C+Daisuke%3BNagano%2C+Tetuo%3BUrano%2C+Yasuteru&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Schedule-Dependent Bortezomib Modulation of Gemcitabine Pharmacokinetics and Pharmacodynamics in Non-Small Cell Lung Cancer and Blood Mononuclear Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867421; 4822782 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Giovannetti, Elisa AU - Ceresa, Cecilia AU - Laan, Adrie C AU - Voortman, Jens AU - Honeywell, Richard AU - Giaccone, Giuseppe AU - Peters, Godefridus J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Pharmacokinetics KW - Non-small cell lung carcinoma KW - Blood KW - Leukocytes (mononuclear) KW - Pharmacodynamics KW - Gemcitabine KW - Pharmacology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Schedule-Dependent+Bortezomib+Modulation+of+Gemcitabine+Pharmacokinetics+and+Pharmacodynamics+in+Non-Small+Cell+Lung+Cancer+and+Blood+Mononuclear+Cells.&rft.au=Giovannetti%2C+Elisa%3BCeresa%2C+Cecilia%3BLaan%2C+Adrie+C%3BVoortman%2C+Jens%3BHoneywell%2C+Richard%3BGiaccone%2C+Giuseppe%3BPeters%2C+Godefridus+J&rft.aulast=Giovannetti&rft.aufirst=Elisa&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Low-dose Metronomic Daily Cyclophosphamide is a Well-tolerated Regimen with Enhanced Efficacy in a Mouse Model of Prostate Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867326; 4821543 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Ferretti, Gianluigi AU - Cardillo, Irene AU - Galluzzo, Paola AU - Spugnini, Enrico P AU - Citro, Gennaro AU - Carlini, Paolo AU - Boccardo, Francesco AU - Balbi, Cecilia AU - Ferrari, Nicoletta AU - Cognetti, Francesco AU - Ruggeri, Enzo M AU - Felici, Alessandra AU - Baldi, Alfonso Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Animal models KW - Cyclophosphamide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Low-dose+Metronomic+Daily+Cyclophosphamide+is+a+Well-tolerated+Regimen+with+Enhanced+Efficacy+in+a+Mouse+Model+of+Prostate+Cancer&rft.au=Ferretti%2C+Gianluigi%3BCardillo%2C+Irene%3BGalluzzo%2C+Paola%3BSpugnini%2C+Enrico+P%3BCitro%2C+Gennaro%3BCarlini%2C+Paolo%3BBoccardo%2C+Francesco%3BBalbi%2C+Cecilia%3BFerrari%2C+Nicoletta%3BCognetti%2C+Francesco%3BRuggeri%2C+Enzo+M%3BFelici%2C+Alessandra%3BBaldi%2C+Alfonso&rft.aulast=Ferretti&rft.aufirst=Gianluigi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IKKss/p50/NFkB/GADD45a: A Novel Apoptotic Cascade Upon Arsenite Exposure. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867277; 4823009 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Huang, Chuanshu AU - Song, Lun AU - Li, Jingxia AU - Zhang, Dongyun AU - Liu, Zheng-gang AU - Ye, Jianping AU - Zhan, Qimin AU - Shen, Han-Ming AU - Whiteman, Matt Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Apoptosis KW - NF-B protein KW - GADD45A protein KW - Arsenite KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=IKKss%2Fp50%2FNFkB%2FGADD45a%3A+A+Novel+Apoptotic+Cascade+Upon+Arsenite+Exposure.&rft.au=Huang%2C+Chuanshu%3BSong%2C+Lun%3BLi%2C+Jingxia%3BZhang%2C+Dongyun%3BLiu%2C+Zheng-gang%3BYe%2C+Jianping%3BZhan%2C+Qimin%3BShen%2C+Han-Ming%3BWhiteman%2C+Matt&rft.aulast=Huang&rft.aufirst=Chuanshu&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ROR2 and Filamin a Contribute to Wnt5A-Mediated Motility in Metastatic Melanoma Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867066; 4822954 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - O'Connell, Michael P AU - Fiori, Jennifer L AU - Camilli, Tura C AU - French, Amanda D AU - Earley, Rachel B AU - Frank, Brittany P AU - Indig, Fred E AU - Hoek, Keith S AU - Taub, Dennis D AU - Bernier, Michel AU - Weeraratna, Ashani T Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Melanoma KW - Motility KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=ROR2+and+Filamin+a+Contribute+to+Wnt5A-Mediated+Motility+in+Metastatic+Melanoma+Cells.&rft.au=O%27Connell%2C+Michael+P%3BFiori%2C+Jennifer+L%3BCamilli%2C+Tura+C%3BFrench%2C+Amanda+D%3BEarley%2C+Rachel+B%3BFrank%2C+Brittany+P%3BIndig%2C+Fred+E%3BHoek%2C+Keith+S%3BTaub%2C+Dennis+D%3BBernier%2C+Michel%3BWeeraratna%2C+Ashani+T&rft.aulast=O%27Connell&rft.aufirst=Michael&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation of 17b-hydroxysteriod Dehydrogenase 1(HSD17B1) and Hormone Receptor-defined Breast Cancer Risk T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866779; 4821366 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gaudet, Mia M AU - Chanock, Stephen AU - Dunning, Alison AU - Driver, Kristy AU - Brinton, Louise A AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Pharoah, Paul AU - Garcia-Closas, Montserrat Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Genetic diversity KW - Breast cancer KW - Hormones KW - Dehydrogenase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genetic+Variation+of+17b-hydroxysteriod+Dehydrogenase+1%28HSD17B1%29+and+Hormone+Receptor-defined+Breast+Cancer+Risk&rft.au=Gaudet%2C+Mia+M%3BChanock%2C+Stephen%3BDunning%2C+Alison%3BDriver%2C+Kristy%3BBrinton%2C+Louise+A%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BPharoah%2C+Paul%3BGarcia-Closas%2C+Montserrat&rft.aulast=Gaudet&rft.aufirst=Mia&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Stem Cell Related Gene Signature in the Stroma of High-Grade Advanced Stage Serous Ovarian Cancer. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866747; 4823111 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Albitar, Lina AU - Ghosh, Sue AU - Wong, Kwong-Kwok AU - Bonome, Tomas AU - Birrer, Michael J AU - Mok, Samuel C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Ovarian cancer KW - Stem cells KW - Stroma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Identification+of+a+Stem+Cell+Related+Gene+Signature+in+the+Stroma+of+High-Grade+Advanced+Stage+Serous+Ovarian+Cancer.&rft.au=Albitar%2C+Lina%3BGhosh%2C+Sue%3BWong%2C+Kwong-Kwok%3BBonome%2C+Tomas%3BBirrer%2C+Michael+J%3BMok%2C+Samuel+C&rft.aulast=Albitar&rft.aufirst=Lina&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combined Assessment of EGFR Pathway-Related Molecular Markers and Prognosis of NSCLC Patients. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866679; 4823077 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Ruiz, Marielle I. Gallegos AU - Floor, Karijn AU - Ferreira, Jose AU - Grunberg, Katrien AU - Thunnissen, Erik AU - Belien, Jeroen A.M. AU - Meijer, Gerrit A AU - Peters, Godefridus J AU - Smit, Egbert F AU - Rodriguez, Jose A AU - Giaccone, Giuseppe Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Epidermal growth factor receptors KW - Prognosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Combined+Assessment+of+EGFR+Pathway-Related+Molecular+Markers+and+Prognosis+of+NSCLC+Patients.&rft.au=Ruiz%2C+Marielle+I.+Gallegos%3BFloor%2C+Karijn%3BFerreira%2C+Jose%3BGrunberg%2C+Katrien%3BThunnissen%2C+Erik%3BBelien%2C+Jeroen+A.M.%3BMeijer%2C+Gerrit+A%3BPeters%2C+Godefridus+J%3BSmit%2C+Egbert+F%3BRodriguez%2C+Jose+A%3BGiaccone%2C+Giuseppe&rft.aulast=Ruiz&rft.aufirst=Marielle+I.&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amphiregulin-induced Luminal Mammary Epithelial Differentiation is Stimulated by 2-methoxyestradiol and 17b-estradiol T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866484; 4820894 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Huh, Jung-Im AU - Qiu, Tinghu AU - Sato, Misako AU - Cataisson, Christophe AU - Michalowska, Aleksandra AU - Catena, Raul AU - Calvo, Alfonso AU - LaVallee, Theresa M AU - Tchou, Julia AU - Herlyn, Meenhard AU - Green, Jeffrey E Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Differentiation KW - 17b-Estradiol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Amphiregulin-induced+Luminal+Mammary+Epithelial+Differentiation+is+Stimulated+by+2-methoxyestradiol+and+17b-estradiol&rft.au=Huh%2C+Jung-Im%3BQiu%2C+Tinghu%3BSato%2C+Misako%3BCataisson%2C+Christophe%3BMichalowska%2C+Aleksandra%3BCatena%2C+Raul%3BCalvo%2C+Alfonso%3BLaVallee%2C+Theresa+M%3BTchou%2C+Julia%3BHerlyn%2C+Meenhard%3BGreen%2C+Jeffrey+E&rft.aulast=Huh&rft.aufirst=Jung-Im&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Particulate Deposition and Clearance in Mouse Lung by Two different Drug Delivery Methods. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866208; 4822838 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Sharma, Sheela AU - Gao, Pu AU - Sochaski, Mark AU - Kohel, Trista AU - Steele, Vernon E Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Particulates KW - Lung KW - Drug delivery KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comparison+of+Particulate+Deposition+and+Clearance+in+Mouse+Lung+by+Two+different+Drug+Delivery+Methods.&rft.au=Sharma%2C+Sheela%3BGao%2C+Pu%3BSochaski%2C+Mark%3BKohel%2C+Trista%3BSteele%2C+Vernon+E&rft.aulast=Sharma&rft.aufirst=Sheela&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Dose Medroxyprogesterone Acetate (MPA) has Anti-angiogenic Properties. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866099; 4820899 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Marshall, Jean-Claude A AU - Collins, Joshua W AU - Miller, Kathy D AU - Steeg, Patricia S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Medroxyprogesterone acetate KW - Acetic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=High+Dose+Medroxyprogesterone+Acetate+%28MPA%29+has+Anti-angiogenic+Properties.&rft.au=Marshall%2C+Jean-Claude+A%3BCollins%2C+Joshua+W%3BMiller%2C+Kathy+D%3BSteeg%2C+Patricia+S&rft.aulast=Marshall&rft.aufirst=Jean-Claude&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional and Molecular Cell Adhesion in the NCI-60 Cancer Cell Line Panel. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866003; 4822947 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Reinhold, William C AU - Ziegler, Micah S AU - Pommier, Yves AU - Weinstein, John N Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Cell adhesion KW - Tumor cell lines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Functional+and+Molecular+Cell+Adhesion+in+the+NCI-60+Cancer+Cell+Line+Panel.&rft.au=Reinhold%2C+William+C%3BZiegler%2C+Micah+S%3BPommier%2C+Yves%3BWeinstein%2C+John+N&rft.aulast=Reinhold&rft.aufirst=William&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Anti-Tumor Effects of Nelfinavir, an HIV Protease Inhibitor, and Chloroquine, an Anti-Malarial Drug, in Lung Cancer Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40865481; 4823537 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - LoPiccolo, Jaclyn AU - Gills, Joell J AU - Kawabata, Shigeru AU - Warfel, Noel A AU - Dennis, Phillip A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Human immunodeficiency virus KW - Lung cancer KW - Drugs KW - Nelfinavir KW - Chloroquine KW - Proteinase inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40865481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Synergistic+Anti-Tumor+Effects+of+Nelfinavir%2C+an+HIV+Protease+Inhibitor%2C+and+Chloroquine%2C+an+Anti-Malarial+Drug%2C+in+Lung+Cancer+Cells.&rft.au=LoPiccolo%2C+Jaclyn%3BGills%2C+Joell+J%3BKawabata%2C+Shigeru%3BWarfel%2C+Noel+A%3BDennis%2C+Phillip+A&rft.aulast=LoPiccolo&rft.aufirst=Jaclyn&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive Breast Cancer Signaling Network Analysis. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864962; 4823287 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Pierobon, Mariaelena AU - Calvert, Valerie S AU - Galdi, Francesca AU - Deng, Jahnhong AU - Wulfkuhle, Julia AU - Signore, Michele AU - Belluco, Claudio AU - Mammano, Enzo AU - Zavagno, Giorgio AU - Nitti, Donato AU - Liotta, Lance AU - Petricoin III, Emanuel F. Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comprehensive+Breast+Cancer+Signaling+Network+Analysis.&rft.au=Pierobon%2C+Mariaelena%3BCalvert%2C+Valerie+S%3BGaldi%2C+Francesca%3BDeng%2C+Jahnhong%3BWulfkuhle%2C+Julia%3BSignore%2C+Michele%3BBelluco%2C+Claudio%3BMammano%2C+Enzo%3BZavagno%2C+Giorgio%3BNitti%2C+Donato%3BLiotta%2C+Lance%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Pierobon&rft.aufirst=Mariaelena&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Associations between a-Tocopherol, b-Carotene, and Retinol and Prostate Cancer Survival in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864849; 4823440 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Watters, Joanne AU - Weinstein, Stephanie AU - Gail, Mitchell AU - Virtamo, Jarmo AU - Albanes, Demetrius Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Prevention KW - Survival KW - Vitamin E KW - Vitamin A KW - B-Carotene KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Associations+between+a-Tocopherol%2C+b-Carotene%2C+and+Retinol+and+Prostate+Cancer+Survival+in+the+Alpha-Tocopherol%2C+Beta-Carotene+Cancer+Prevention+%28ATBC%29+Study.&rft.au=Watters%2C+Joanne%3BWeinstein%2C+Stephanie%3BGail%2C+Mitchell%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Watters&rft.aufirst=Joanne&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Pharmacologic Evaluations of R406/R788, a Multi-Kinase Inhibitor Which Exhibits Unique, Differential In Vitro Anticancer Activity as Well as In Vivo Antitumor Efficacy Following Oral Adminstration. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864780; 4824109 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Alley, Michael C AU - Hollingshead, Melinda G AU - Pacula-Cox, Christine M AU - Carter, John P AU - Jacob, William F AU - Pine, Polly R Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Antitumor activity KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Preclinical+Pharmacologic+Evaluations+of+R406%2FR788%2C+a+Multi-Kinase+Inhibitor+Which+Exhibits+Unique%2C+Differential+In+Vitro+Anticancer+Activity+as+Well+as+In+Vivo+Antitumor+Efficacy+Following+Oral+Adminstration.&rft.au=Alley%2C+Michael+C%3BHollingshead%2C+Melinda+G%3BPacula-Cox%2C+Christine+M%3BCarter%2C+John+P%3BJacob%2C+William+F%3BPine%2C+Polly+R&rft.aulast=Alley&rft.aufirst=Michael&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Indenoisoquinolines NSC 725776 and NSC 724998 Inhibit Angiogenesis: UH2AX is Potential Pharmacologic Biomarker T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864635; 4820897 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kaur, Gurmeet AU - Frary, Sadie G AU - Thillainathan, Jagadambal AU - Hollingshead, Melinda G AU - Pommier, Yves AU - Parchment, Ralph E AU - Tomaszewski, Joseph E AU - Doroshow, James H Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Bioindicators KW - Angiogenesis KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Indenoisoquinolines+NSC+725776+and+NSC+724998+Inhibit+Angiogenesis%3A+UH2AX+is+Potential+Pharmacologic+Biomarker&rft.au=Kaur%2C+Gurmeet%3BFrary%2C+Sadie+G%3BThillainathan%2C+Jagadambal%3BHollingshead%2C+Melinda+G%3BPommier%2C+Yves%3BParchment%2C+Ralph+E%3BTomaszewski%2C+Joseph+E%3BDoroshow%2C+James+H&rft.aulast=Kaur&rft.aufirst=Gurmeet&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pediatric Preclinical Testing Program (PPTP) Evaluation of the Topoisomerase I Inhibitor Topotecan. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864519; 4822863 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Carol, Hernan AU - Morton, Christopher L AU - Houghton, Peter J AU - Maris, John M AU - Friedman, Henry S AU - Keir, Stephen T AU - Gorlick, Richard AU - Kolb, E Anders AU - Smith, Malcolm A AU - Lock, Richard B Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pediatrics KW - Topotecan KW - DNA topoisomerase KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Pediatric+Preclinical+Testing+Program+%28PPTP%29+Evaluation+of+the+Topoisomerase+I+Inhibitor+Topotecan.&rft.au=Carol%2C+Hernan%3BMorton%2C+Christopher+L%3BHoughton%2C+Peter+J%3BMaris%2C+John+M%3BFriedman%2C+Henry+S%3BKeir%2C+Stephen+T%3BGorlick%2C+Richard%3BKolb%2C+E+Anders%3BSmith%2C+Malcolm+A%3BLock%2C+Richard+B&rft.aulast=Carol&rft.aufirst=Hernan&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Omega-3 Fatty Acid Effects on Human Breast Carcinoma Cell Invasion T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864388; 4820825 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Rubino, Mark AU - Adair, Jennifer E AU - Roberts, John D AU - Olden, Ken Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Fatty acids KW - Breast carcinoma KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Omega-3+Fatty+Acid+Effects+on+Human+Breast+Carcinoma+Cell+Invasion&rft.au=Rubino%2C+Mark%3BAdair%2C+Jennifer+E%3BRoberts%2C+John+D%3BOlden%2C+Ken&rft.aulast=Rubino&rft.aufirst=Mark&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Organochlorine Exposure, Immune Gene Variation, and Risk of Non-Hodgkin Lymphoma. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864373; 4823399 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Colt, Joanne S AU - Rothman, Nathaniel AU - Severson, Richard K AU - Hartge, Patricia AU - Cerhan, James R AU - Chatterjee, Nilanjan AU - Cozen, Wendy AU - Morton, Lindsay AU - De Roos, Anneclaire AU - Davis, Scott AU - Chanock, Stephen AU - Wang, Sophia Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lymphoma KW - Organochlorine compounds KW - Chlorine compounds KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Organochlorine+Exposure%2C+Immune+Gene+Variation%2C+and+Risk+of+Non-Hodgkin+Lymphoma.&rft.au=Colt%2C+Joanne+S%3BRothman%2C+Nathaniel%3BSeverson%2C+Richard+K%3BHartge%2C+Patricia%3BCerhan%2C+James+R%3BChatterjee%2C+Nilanjan%3BCozen%2C+Wendy%3BMorton%2C+Lindsay%3BDe+Roos%2C+Anneclaire%3BDavis%2C+Scott%3BChanock%2C+Stephen%3BWang%2C+Sophia&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Responses of Five NO-NSAIDs in a Human Cell Melanoma Prevention Assay T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864356; 4820812 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Elmore, Eugene AU - Jain, Aarti AU - Steele, Vernon E AU - Redpath, J Leslie Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Melanoma KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comparative+Responses+of+Five+NO-NSAIDs+in+a+Human+Cell+Melanoma+Prevention+Assay&rft.au=Elmore%2C+Eugene%3BJain%2C+Aarti%3BSteele%2C+Vernon+E%3BRedpath%2C+J+Leslie&rft.aulast=Elmore&rft.aufirst=Eugene&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Upregulation of Interleukin 13 Receptor (IL-13R) by Adrenomedullin (AM) in Human Prostate Cancer Model T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864329; 4820789 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Joshi, Bharat H AU - Leland, Pamela AU - Calvo, Alfonso AU - Montuenga, Luis AU - Green, Jeffrey AU - Puri, Raj K Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Adrenomedullin KW - Interleukin 13 receptors KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=In+Vivo+Upregulation+of+Interleukin+13+Receptor+%28IL-13R%29+by+Adrenomedullin+%28AM%29+in+Human+Prostate+Cancer+Model&rft.au=Joshi%2C+Bharat+H%3BLeland%2C+Pamela%3BCalvo%2C+Alfonso%3BMontuenga%2C+Luis%3BGreen%2C+Jeffrey%3BPuri%2C+Raj+K&rft.aulast=Joshi&rft.aufirst=Bharat&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Basal Activation of Erk and Mek in Follicular Lymphoma In Vivo. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864298; 4823218 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kovach, Alexandra E AU - Devor, Christopher AU - Bandle, Russell AU - Bond, Amelia AU - Shih, Joanna AU - Jaffe, Elaine S AU - Calvo, Katherine R Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lymphoma KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Basal+Activation+of+Erk+and+Mek+in+Follicular+Lymphoma+In+Vivo.&rft.au=Kovach%2C+Alexandra+E%3BDevor%2C+Christopher%3BBandle%2C+Russell%3BBond%2C+Amelia%3BShih%2C+Joanna%3BJaffe%2C+Elaine+S%3BCalvo%2C+Katherine+R&rft.aulast=Kovach&rft.aufirst=Alexandra&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Seg-1 Cell Resistance to Polyphenon E May be due to Increased BCL2 Expression. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864168; 4823635 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Borgovan, Theodor M AU - Bellistri, John-Paul S AU - Slack, Kristen N AU - Desai, Manisha AU - Kopelovich, Levy AU - Weinstein, I Bernard AU - Joe, Andrew K Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Seg-1+Cell+Resistance+to+Polyphenon+E+May+be+due+to+Increased+BCL2+Expression.&rft.au=Borgovan%2C+Theodor+M%3BBellistri%2C+John-Paul+S%3BSlack%2C+Kristen+N%3BDesai%2C+Manisha%3BKopelovich%2C+Levy%3BWeinstein%2C+I+Bernard%3BJoe%2C+Andrew+K&rft.aulast=Borgovan&rft.aufirst=Theodor&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a RNA Quality Control Assay for FFPE Samples. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863972; 4823345 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Xu, Qiang AU - Oades, Kahuku AU - Stowe, Jennifer AU - Tedeschi, Neil AU - Vo, Lien AU - Vansant, Gordon AU - Birrer, Michael AU - Ozbun, Laurent AU - Monforte, Joseph Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Quality control KW - RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Development+of+a+RNA+Quality+Control+Assay+for+FFPE+Samples.&rft.au=Xu%2C+Qiang%3BOades%2C+Kahuku%3BStowe%2C+Jennifer%3BTedeschi%2C+Neil%3BVo%2C+Lien%3BVansant%2C+Gordon%3BBirrer%2C+Michael%3BOzbun%2C+Laurent%3BMonforte%2C+Joseph&rft.aulast=Xu&rft.aufirst=Qiang&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Triple Combination of Treatments for Synergistic Cancer Cell Killing -Implication for a More Efficient Novel Cancer Treatment Principle. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863935; 4823536 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Yu, Ming AU - Van Waes, Carter Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Triple+Combination+of+Treatments+for+Synergistic+Cancer+Cell+Killing+-Implication+for+a+More+Efficient+Novel+Cancer+Treatment+Principle.&rft.au=Yu%2C+Ming%3BVan+Waes%2C+Carter&rft.aulast=Yu&rft.aufirst=Ming&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteasome Inhibitors Increase Tubulin Polymerization and Stabilization in Tissue Culture Cells. A Possible Mechanism Contributing to Peripheral Neuropathy and Cellular Toxicity Following Proteasome Inhibition. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863776; 4822788 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Poruchynsky, Marianne S AU - Sackett, Dan L AU - Robey, Robert W AU - Ward, Yvona AU - Annunziata, Christina AU - Fojo, Tito Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Toxicity KW - Tissue culture KW - Proteasome inhibitors KW - Proteasomes KW - Tubulin KW - Polymerization KW - Peripheral neuropathy KW - Stabilizing KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Proteasome+Inhibitors+Increase+Tubulin+Polymerization+and+Stabilization+in+Tissue+Culture+Cells.+A+Possible+Mechanism+Contributing+to+Peripheral+Neuropathy+and+Cellular+Toxicity+Following+Proteasome+Inhibition.&rft.au=Poruchynsky%2C+Marianne+S%3BSackett%2C+Dan+L%3BRobey%2C+Robert+W%3BWard%2C+Yvona%3BAnnunziata%2C+Christina%3BFojo%2C+Tito&rft.aulast=Poruchynsky&rft.aufirst=Marianne&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reproducibility and Correlation of Multiplex Cytokine Measurements in Serum and Plasma from Asymptomatic Individuals. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863664; 4823391 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wong, Hui-Lee AU - Fears, Thomas R AU - Lubin, Jay H AU - Ji, Shaoquan AU - Rabkin, Charles S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cytokines KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Reproducibility+and+Correlation+of+Multiplex+Cytokine+Measurements+in+Serum+and+Plasma+from+Asymptomatic+Individuals.&rft.au=Wong%2C+Hui-Lee%3BFears%2C+Thomas+R%3BLubin%2C+Jay+H%3BJi%2C+Shaoquan%3BRabkin%2C+Charles+S&rft.aulast=Wong&rft.aufirst=Hui-Lee&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acral Lentiginous Melanoma: Incidence and Survival Patterns in the United States, 1986-2004. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863612; 4823383 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Bradford, Porcia T AU - Goldstein, Alisa M AU - McMaster, Mary L AU - Tucker, Margaret A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - USA KW - Melanoma KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Acral+Lentiginous+Melanoma%3A+Incidence+and+Survival+Patterns+in+the+United+States%2C+1986-2004.&rft.au=Bradford%2C+Porcia+T%3BGoldstein%2C+Alisa+M%3BMcMaster%2C+Mary+L%3BTucker%2C+Margaret+A&rft.aulast=Bradford&rft.aufirst=Porcia&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preventive Effects of Multiple Agents (RXR Agonists Targretin and UAB-30, Atorvastatin [Lipitor] and Rosiglitazone) in MMTV Transgenic Mouse Models. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863464; 4822832 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Lubet, Ronald A AU - Ruppert, Michael J AU - Muccio, Donald D AU - You, Ming AU - Brouillette, Wayne J AU - Atigadda, Reddy AU - Steele, Vernon E AU - Juliana, M Margaret AU - Grubbs, Clinton J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Animal models KW - Rosiglitazone KW - Retinoid X receptors KW - Transgenic mice KW - Atorvastatin KW - Mouse mammary tumor virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Preventive+Effects+of+Multiple+Agents+%28RXR+Agonists+Targretin+and+UAB-30%2C+Atorvastatin+%5BLipitor%5D+and+Rosiglitazone%29+in+MMTV+Transgenic+Mouse+Models.&rft.au=Lubet%2C+Ronald+A%3BRuppert%2C+Michael+J%3BMuccio%2C+Donald+D%3BYou%2C+Ming%3BBrouillette%2C+Wayne+J%3BAtigadda%2C+Reddy%3BSteele%2C+Vernon+E%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Family History and Upper Gastrointestinal Cancers in China. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863443; 4823410 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gao, Ying AU - Hu, Nan AU - Han, Xiaoyou AU - Giffen, Carol AU - Ding, Ti AU - Goldstein, Alisa AU - Taylor, Philip R Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - China, People's Rep. KW - Cancer KW - Genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Family+History+and+Upper+Gastrointestinal+Cancers+in+China.&rft.au=Gao%2C+Ying%3BHu%2C+Nan%3BHan%2C+Xiaoyou%3BGiffen%2C+Carol%3BDing%2C+Ti%3BGoldstein%2C+Alisa%3BTaylor%2C+Philip+R&rft.aulast=Gao&rft.aufirst=Ying&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Genomic Scale Candidate Gene Scan Aimed at Identifying Aetiological Pathways in Myeloma. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863414; 4823401 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Johnson, David C AU - Dickens, Nicholas J AU - Ramos, Christine AU - Walker, Brian A AU - Berndt, Sonja I AU - Jenner, Matthew W AU - Baris, Dalsu AU - Davies, Faith E AU - Durie, Brian G AU - Van Ness, Brian AU - Morgan, Gareth J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Myeloma KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+Genomic+Scale+Candidate+Gene+Scan+Aimed+at+Identifying+Aetiological+Pathways+in+Myeloma.&rft.au=Johnson%2C+David+C%3BDickens%2C+Nicholas+J%3BRamos%2C+Christine%3BWalker%2C+Brian+A%3BBerndt%2C+Sonja+I%3BJenner%2C+Matthew+W%3BBaris%2C+Dalsu%3BDavies%2C+Faith+E%3BDurie%2C+Brian+G%3BVan+Ness%2C+Brian%3BMorgan%2C+Gareth+J&rft.aulast=Johnson&rft.aufirst=David&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LB-1, an Inhibitor of Serine-threonine Protein Phosphatase PP2A, Suppresses the Growth of Glioblastoma Cells In Vitro and In Vivo T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863211; 4822317 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Lu, Jie AU - Ikejiri, Barbara AU - Golpayegani, Nahal AU - Kim, Stephanie AU - Mushlin, Harry AU - Johnson, Francis AU - Kovach, John S AU - Lonser, Russell AU - Zhuang, Zhengping Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Glioblastoma cells KW - Protein phosphatase KW - Phosphatase KW - Inhibitors KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=LB-1%2C+an+Inhibitor+of+Serine-threonine+Protein+Phosphatase+PP2A%2C+Suppresses+the+Growth+of+Glioblastoma+Cells+In+Vitro+and+In+Vivo&rft.au=Lu%2C+Jie%3BIkejiri%2C+Barbara%3BGolpayegani%2C+Nahal%3BKim%2C+Stephanie%3BMushlin%2C+Harry%3BJohnson%2C+Francis%3BKovach%2C+John+S%3BLonser%2C+Russell%3BZhuang%2C+Zhengping&rft.aulast=Lu&rft.aufirst=Jie&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemopreventive Effects of Cucumaria frondosa Lipid Extract in Rat Colon Carcinogenesis and in a Human Colon Cancer Cell Line. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863205; 4822851 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Janakiram, Naveena B AU - Zhang, Yuting AU - Choi, Chang-In AU - Mohammed, Altaf AU - Steele, Vernon E AU - Rao, Chinthalapally V Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colon cancer KW - Lipids KW - Carcinogenesis KW - Tumor cell lines KW - Cucumaria frondosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Chemopreventive+Effects+of+Cucumaria+frondosa+Lipid+Extract+in+Rat+Colon+Carcinogenesis+and+in+a+Human+Colon+Cancer+Cell+Line.&rft.au=Janakiram%2C+Naveena+B%3BZhang%2C+Yuting%3BChoi%2C+Chang-In%3BMohammed%2C+Altaf%3BSteele%2C+Vernon+E%3BRao%2C+Chinthalapally+V&rft.aulast=Janakiram&rft.aufirst=Naveena&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - EZH2 is Overexpressed in Medulloblastomas and can be Targeted by 3-Deazaneplanocin A. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863050; 4823687 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Mir, Shahryar E AU - Kaspers, Gertjan L AU - Kwidama, Zinia J AU - Wurdinger, Thomas AU - Noske, David P AU - Aronica, Eleonora AU - van der, Paul Valk AU - van Dannis, G Vuurden AU - Marquez, Victor E AU - Drukarch, Benjamin AU - Cloos, Jacqueline Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Medulloblastoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=EZH2+is+Overexpressed+in+Medulloblastomas+and+can+be+Targeted+by+3-Deazaneplanocin+A.&rft.au=Mir%2C+Shahryar+E%3BKaspers%2C+Gertjan+L%3BKwidama%2C+Zinia+J%3BWurdinger%2C+Thomas%3BNoske%2C+David+P%3BAronica%2C+Eleonora%3Bvan+der%2C+Paul+Valk%3Bvan+Dannis%2C+G+Vuurden%3BMarquez%2C+Victor+E%3BDrukarch%2C+Benjamin%3BCloos%2C+Jacqueline&rft.aulast=Mir&rft.aufirst=Shahryar&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pediatric Preclinical Testing Program (PPTP) Evaluation of the Aurora a Kinase Inhibitor MLN8237. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863043; 4822864 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Houghton, Peter J AU - Morton, Christopher L AU - Maris, John M AU - Courtright, Joshua AU - Carol, Hernan AU - Lock, Richard B AU - Friedman, Henry S AU - Keir, Stephen T AU - Gorlick, Richard AU - Kolb, E Anders AU - Reynolds, C Patrick AU - Kang, Min AU - Smith, Malcolm A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pediatrics KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Pediatric+Preclinical+Testing+Program+%28PPTP%29+Evaluation+of+the+Aurora+a+Kinase+Inhibitor+MLN8237.&rft.au=Houghton%2C+Peter+J%3BMorton%2C+Christopher+L%3BMaris%2C+John+M%3BCourtright%2C+Joshua%3BCarol%2C+Hernan%3BLock%2C+Richard+B%3BFriedman%2C+Henry+S%3BKeir%2C+Stephen+T%3BGorlick%2C+Richard%3BKolb%2C+E+Anders%3BReynolds%2C+C+Patrick%3BKang%2C+Min%3BSmith%2C+Malcolm+A&rft.aulast=Houghton&rft.aufirst=Peter&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive Signal Pathway Profiling of Localized and Metastatic Human Prostate Cancer. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40862534; 4823474 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wulfkuhle, Julia D AU - Grubb III, Robert L AU - Deng, Jianghong AU - Pinto, Peter A AU - Mohler, James L AU - Chinnaiyan, Arul AU - Rubin, Mark A AU - Linehan, W Marston AU - Liotta, Lance A AU - Petricoin III, Emanuel F. Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Metastases KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40862534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comprehensive+Signal+Pathway+Profiling+of+Localized+and+Metastatic+Human+Prostate+Cancer.&rft.au=Wulfkuhle%2C+Julia+D%3BGrubb+III%2C+Robert+L%3BDeng%2C+Jianghong%3BPinto%2C+Peter+A%3BMohler%2C+James+L%3BChinnaiyan%2C+Arul%3BRubin%2C+Mark+A%3BLinehan%2C+W+Marston%3BLiotta%2C+Lance+A%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Wulfkuhle&rft.aufirst=Julia&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combination of Interleukin-15 with Anti-CD40 Antibody Provides Enhanced Therapeutic Efficacy for a Mouse Lung Metastasis Model of Colon Cancer. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40862126; 4823567 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Zhang, Meili AU - Yao, Zhengsheng AU - Dubois, Sigrid P AU - Ju, Wei AU - Chen, Jing AU - Muller, Jurgen AU - Waldmann, Thomas A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colon cancer KW - Lung KW - Animal models KW - Antibodies KW - Interleukin 15 KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40862126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Combination+of+Interleukin-15+with+Anti-CD40+Antibody+Provides+Enhanced+Therapeutic+Efficacy+for+a+Mouse+Lung+Metastasis+Model+of+Colon+Cancer.&rft.au=Zhang%2C+Meili%3BYao%2C+Zhengsheng%3BDubois%2C+Sigrid+P%3BJu%2C+Wei%3BChen%2C+Jing%3BMuller%2C+Jurgen%3BWaldmann%2C+Thomas+A&rft.aulast=Zhang&rft.aufirst=Meili&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Active Fraction of GSK3b in Cancer Cells by Non-Radioisotopic In Vitro Kinase Assay. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40862034; 4823488 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Mai, Wei AU - Shakoori, Abbas AU - Miyashita, Katsuyoshi AU - Zhang, Bin AU - Motoo, Yoshiharu AU - Kawakami, Kazuyuki AU - Takahashi, Yutaka AU - Minamoto, Toshinari Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40862034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Detection+of+Active+Fraction+of+GSK3b+in+Cancer+Cells+by+Non-Radioisotopic+In+Vitro+Kinase+Assay.&rft.au=Mai%2C+Wei%3BShakoori%2C+Abbas%3BMiyashita%2C+Katsuyoshi%3BZhang%2C+Bin%3BMotoo%2C+Yoshiharu%3BKawakami%2C+Kazuyuki%3BTakahashi%2C+Yutaka%3BMinamoto%2C+Toshinari&rft.aulast=Mai&rft.aufirst=Wei&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling Reveals Distinct Changes in Cardiovascular Genes in PC3 Prostate Carcinoma Cells and Normal Cells Treated with NSAIDs and COX-2 RNAi. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861969; 4823467 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Palayoor, Sanjeewani T AU - Aryankalayil, Molykutty J AU - Cerna, David AU - Coleman, C Norman Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate carcinoma KW - Gene expression KW - Cyclooxygenase-2 KW - Nonsteroidal antiinflammatory drugs KW - Tumors KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Gene+Expression+Profiling+Reveals+Distinct+Changes+in+Cardiovascular+Genes+in+PC3+Prostate+Carcinoma+Cells+and+Normal+Cells+Treated+with+NSAIDs+and+COX-2+RNAi.&rft.au=Palayoor%2C+Sanjeewani+T%3BAryankalayil%2C+Molykutty+J%3BCerna%2C+David%3BColeman%2C+C+Norman&rft.aulast=Palayoor&rft.aufirst=Sanjeewani&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - JS-K, a Nitric Oxide-releasing Prodrug, Inhibits Growth of Lung Adenocarcinoma Cells through Increase in Oxidative/Nitrosative Stress, DNA Damage and Activation of Apoptosis. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861905; 4822298 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Maciag, Anna E AU - Chakrapani, Harinath AU - Gupta, Meghana B AU - Shami, Paul J AU - Saavedra, Joseph E AU - Anderson, Lucy M AU - Keefer, Larry K Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung KW - Stress KW - Apoptosis KW - Adenocarcinoma KW - DNA damage KW - Prodrugs KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Cancer&rft.atitle=Adoptive+cell+transfer%3A+a+clinical+path+to+effective+cancer+immunotherapy&rft.au=Rosenberg%2C+Steven+A%3BRestifo%2C+Nicholas+P%3BYang%2C+James+C%3BMorgan%2C+Richard+A%3BDudley%2C+Mark+E&rft.aulast=Rosenberg&rft.aufirst=Steven&rft.date=2008-04-01&rft.volume=8&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc2355 L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correlation between Clinical Outcome and Growth Factor Expression as Determined by Immunohistochemical Staining in Osteogenic Sarcoma. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861878; 4823428 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Abdeen, Ayesha AU - Chou, Alexander AU - Healey, John H AU - Khanna, Chand AU - Gorlick, Richard Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Growth factors KW - Osteosarcoma KW - Growth KW - Staining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Correlation+between+Clinical+Outcome+and+Growth+Factor+Expression+as+Determined+by+Immunohistochemical+Staining+in+Osteogenic+Sarcoma.&rft.au=Abdeen%2C+Ayesha%3BChou%2C+Alexander%3BHealey%2C+John+H%3BKhanna%2C+Chand%3BGorlick%2C+Richard&rft.aulast=Abdeen&rft.aufirst=Ayesha&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation in Genes Participating in Apoptosis and Bladder Cancer Risk. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861813; 4823406 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Figueroa, Jonine AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Malats, Nuria AU - Silverman, Debra AU - Kogevinas, Manolis AU - Yeager, Meredith AU - Welch, Robert AU - Dosemeci, Mustafa AU - Tardon, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - Garcia-Closas, Reina AU - Castano-Vinyals, Gemma AU - Chanock, Stephen AU - Rothman, Nathaniel Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Genetic diversity KW - Apoptosis KW - Urinary bladder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genetic+Variation+in+Genes+Participating+in+Apoptosis+and+Bladder+Cancer+Risk.&rft.au=Figueroa%2C+Jonine%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BMalats%2C+Nuria%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarcia-Closas%2C+Reina%3BCastano-Vinyals%2C+Gemma%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Functional Validation of Deregulated Genes in Colorectal Cancers. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861760; 4823475 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Grade, Marian AU - Hummon, Amanda B AU - Camps, Jordi AU - Emons, Georg AU - Difilippantonio, Michael J AU - Ghadimi, Michael AU - Caplen, Natasha J AU - Ried, Thomas Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colorectal cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Identification+and+Functional+Validation+of+Deregulated+Genes+in+Colorectal+Cancers.&rft.au=Grade%2C+Marian%3BHummon%2C+Amanda+B%3BCamps%2C+Jordi%3BEmons%2C+Georg%3BDifilippantonio%2C+Michael+J%3BGhadimi%2C+Michael%3BCaplen%2C+Natasha+J%3BRied%2C+Thomas&rft.aulast=Grade&rft.aufirst=Marian&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topology of NGEP, a Prostate Specific Cell: Cell Junction Protein and a Potential Prostate Immunotherapeutic Target. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861732; 4823479 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Das, Sudipto AU - Hahn, YoonSoo AU - Bera, Tapan K AU - Nagata, Satoshi AU - Willingham, Mark C AU - Peehl, Donna M AU - Lee, Byungkook AU - Pastan, Ira Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate KW - Cell junctions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Topology+of+NGEP%2C+a+Prostate+Specific+Cell%3A+Cell+Junction+Protein+and+a+Potential+Prostate+Immunotherapeutic+Target.&rft.au=Das%2C+Sudipto%3BHahn%2C+YoonSoo%3BBera%2C+Tapan+K%3BNagata%2C+Satoshi%3BWillingham%2C+Mark+C%3BPeehl%2C+Donna+M%3BLee%2C+Byungkook%3BPastan%2C+Ira&rft.aulast=Das&rft.aufirst=Sudipto&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Detection of gH2AX, a Nuclear DNA-Repair Pharmacodynamic Marker, in Individual Circulating Tumor Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861641; 4823341 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wang, Lihua H AU - Pfister, Thomas D AU - Kinders, Robert J AU - Parchment, Ralph E AU - Kummar, Shivaani AU - Gutierrez, Martin AU - Murgo, Anthony AU - Tomaszewski, Joseph E AU - Doroshow, James H Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Tumor cells KW - Pharmacodynamics KW - Tumors KW - Pharmacology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Direct+Detection+of+gH2AX%2C+a+Nuclear+DNA-Repair+Pharmacodynamic+Marker%2C+in+Individual+Circulating+Tumor+Cells.&rft.au=Wang%2C+Lihua+H%3BPfister%2C+Thomas+D%3BKinders%2C+Robert+J%3BParchment%2C+Ralph+E%3BKummar%2C+Shivaani%3BGutierrez%2C+Martin%3BMurgo%2C+Anthony%3BTomaszewski%2C+Joseph+E%3BDoroshow%2C+James+H&rft.aulast=Wang&rft.aufirst=Lihua&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Immune Response Genotypes on Non-Hodgkin Lymhoma Risk is Modified by a History of Atopic Conditions. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861187; 4823398 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Cozen, Wendy AU - Hartge, Patricia AU - Engels, Eric A AU - Cerhan, James R AU - Severson, Richard K AU - Davis, Scott AU - Colt, Joanne AU - Ward, Mary H AU - Linet, Martha S AU - Bernstein, Leslie AU - Rothman, Nathaniel AU - Wang, Sophia S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Immune response KW - Historical account KW - Genotypes KW - Atopy KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+Effect+of+Immune+Response+Genotypes+on+Non-Hodgkin+Lymhoma+Risk+is+Modified+by+a+History+of+Atopic+Conditions.&rft.au=Cozen%2C+Wendy%3BHartge%2C+Patricia%3BEngels%2C+Eric+A%3BCerhan%2C+James+R%3BSeverson%2C+Richard+K%3BDavis%2C+Scott%3BColt%2C+Joanne%3BWard%2C+Mary+H%3BLinet%2C+Martha+S%3BBernstein%2C+Leslie%3BRothman%2C+Nathaniel%3BWang%2C+Sophia+S&rft.aulast=Cozen&rft.aufirst=Wendy&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Theraputic Effect of Adenoviral Vaccine Expressing ErbB-2/neu on Established Mouse Breast Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861102; 4822433 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Terabe, Masaki AU - Park, JongMyun AU - Steel, Jason C AU - Forni, Guido AU - Sakai, Yoshio AU - Morris, John C AU - Berzofsky, Jay A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Vaccines KW - Breast cancer KW - ErbB-2 protein KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Theraputic+Effect+of+Adenoviral+Vaccine+Expressing+ErbB-2%2Fneu+on+Established+Mouse+Breast+Cancer&rft.au=Terabe%2C+Masaki%3BPark%2C+JongMyun%3BSteel%2C+Jason+C%3BForni%2C+Guido%3BSakai%2C+Yoshio%3BMorris%2C+John+C%3BBerzofsky%2C+Jay+A&rft.aulast=Terabe&rft.aufirst=Masaki&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Breast Cancer Brain Metastasis. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40860875; 4823717 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Felding-Habermann, Brunhilde AU - Chen, Emily I AU - Krueger, Joseph S AU - Lorger, Mihaela AU - Staflin, Karin AU - Yates III, John R AU - Steeg, Patricia S AU - Palmieri, Diane AU - Kroener, Joan Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Brain KW - Breast cancer KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Mechanisms+of+Breast+Cancer+Brain+Metastasis.&rft.au=Felding-Habermann%2C+Brunhilde%3BChen%2C+Emily+I%3BKrueger%2C+Joseph+S%3BLorger%2C+Mihaela%3BStaflin%2C+Karin%3BYates+III%2C+John+R%3BSteeg%2C+Patricia+S%3BPalmieri%2C+Diane%3BKroener%2C+Joan&rft.aulast=Felding-Habermann&rft.aufirst=Brunhilde&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Folate Pathway Polymorphisms are Related to Neuropsychological Impairment in Childhood Leukemia Survivors. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40860659; 4823427 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kamdar, Kala Y AU - Potter, Brian S AU - Yan, Jingrong AU - Harris, Lynette L AU - Krull, Kevin R AU - Brouwers, Pim AU - Bondy, Melissa L AU - El-Zein, Randa A AU - Okcu, M Fatih Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Leukemia KW - Children KW - Folic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Folate+Pathway+Polymorphisms+are+Related+to+Neuropsychological+Impairment+in+Childhood+Leukemia+Survivors.&rft.au=Kamdar%2C+Kala+Y%3BPotter%2C+Brian+S%3BYan%2C+Jingrong%3BHarris%2C+Lynette+L%3BKrull%2C+Kevin+R%3BBrouwers%2C+Pim%3BBondy%2C+Melissa+L%3BEl-Zein%2C+Randa+A%3BOkcu%2C+M+Fatih&rft.aulast=Kamdar&rft.aufirst=Kala&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Constitutive Expression of Human Keratin 14 Gene in Mouse Lung Initiates Squamous Differentiation, Premalignant Lesions and Modulates Tumorigenesis. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40860645; 4822921 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Dakir, El Habib AU - Jensen-Taubman, Sandra AU - Feigenbaum, Lionel AU - Linnoila, Ilona Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung KW - Lesions KW - Tumorigenesis KW - Differentiation KW - Keratin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Constitutive+Expression+of+Human+Keratin+14+Gene+in+Mouse+Lung+Initiates+Squamous+Differentiation%2C+Premalignant+Lesions+and+Modulates+Tumorigenesis.&rft.au=Dakir%2C+El+Habib%3BJensen-Taubman%2C+Sandra%3BFeigenbaum%2C+Lionel%3BLinnoila%2C+Ilona&rft.aulast=Dakir&rft.aufirst=El&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GC Binding Factor 2 (GCF2) Regulates the Activation of Small GTP-binding Protein, Rho A T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40860257; 4821715 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Ohtsuka, Hideo AU - Oikawa, Masaya AU - Rikiyama, Toshiki AU - Motoi, Fuyuhiko AU - Katayose, Yu AU - Egawa, Shinichi AU - Unno, Michiaki AU - Johnson, Alfred C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Guanylate cyclase KW - GTP-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=GC+Binding+Factor+2+%28GCF2%29+Regulates+the+Activation+of+Small+GTP-binding+Protein%2C+Rho+A&rft.au=Ohtsuka%2C+Hideo%3BOikawa%2C+Masaya%3BRikiyama%2C+Toshiki%3BMotoi%2C+Fuyuhiko%3BKatayose%2C+Yu%3BEgawa%2C+Shinichi%3BUnno%2C+Michiaki%3BJohnson%2C+Alfred+C&rft.aulast=Ohtsuka&rft.aufirst=Hideo&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pediatric Preclinical Testing Program (PPTP) Evaluation of the MEK1/2 Inhibitor AZD6244 (ARRY-142886). T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859988; 4822865 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Smith, Malcolm A AU - Morton, Christopher AU - Maris, John M AU - Courtright, Joshua AU - Kolb, E Anders AU - Gorlick, Richard AU - Carol, Hernan AU - Lock, Richard B AU - Friedman, Henry S AU - Keir, Stephen T AU - Kang, Min AU - Reynolds, C Patrick AU - Houghton, Peter J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pediatrics KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Pediatric+Preclinical+Testing+Program+%28PPTP%29+Evaluation+of+the+MEK1%2F2+Inhibitor+AZD6244+%28ARRY-142886%29.&rft.au=Smith%2C+Malcolm+A%3BMorton%2C+Christopher%3BMaris%2C+John+M%3BCourtright%2C+Joshua%3BKolb%2C+E+Anders%3BGorlick%2C+Richard%3BCarol%2C+Hernan%3BLock%2C+Richard+B%3BFriedman%2C+Henry+S%3BKeir%2C+Stephen+T%3BKang%2C+Min%3BReynolds%2C+C+Patrick%3BHoughton%2C+Peter+J&rft.aulast=Smith&rft.aufirst=Malcolm&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of JS-K, a Novel Anti-Cancer Nitric Oxide Prodrug, on Gene Expression in Human Myeloid Leukemia Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859971; 4822705 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Shami, Paul J AU - Malaviya, Swati AU - Tari, Ana AU - Saavedra, Joseph E AU - Keefer, Larry K AU - Tokar, Erik AU - Sun, Yang AU - Waalkes, Michael P AU - Liu, Jie Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Myeloid leukemia KW - Nitric oxide KW - Gene expression KW - Prodrugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Effect+of+JS-K%2C+a+Novel+Anti-Cancer+Nitric+Oxide+Prodrug%2C+on+Gene+Expression+in+Human+Myeloid+Leukemia+Cells.&rft.au=Shami%2C+Paul+J%3BMalaviya%2C+Swati%3BTari%2C+Ana%3BSaavedra%2C+Joseph+E%3BKeefer%2C+Larry+K%3BTokar%2C+Erik%3BSun%2C+Yang%3BWaalkes%2C+Michael+P%3BLiu%2C+Jie&rft.aulast=Shami&rft.aufirst=Paul&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MicroRNA miR-16 Linked to the Development and Progression of B Cell Malignancies in the NZB de novo Murine Model of CLL. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859882; 4822941 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Salerno, Erica AU - Scaglione, Brian AU - Coffman, Frederick AU - Fernandes, Helen AU - Marti, Gerald E AU - Baskar, Sivasubramanian AU - Rader, Christoph AU - Raveche, Elizabeth Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lymphocytes B KW - Animal models KW - Malignancy KW - MiRNA KW - Chronic lymphatic leukemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=MicroRNA+miR-16+Linked+to+the+Development+and+Progression+of+B+Cell+Malignancies+in+the+NZB+de+novo+Murine+Model+of+CLL.&rft.au=Salerno%2C+Erica%3BScaglione%2C+Brian%3BCoffman%2C+Frederick%3BFernandes%2C+Helen%3BMarti%2C+Gerald+E%3BBaskar%2C+Sivasubramanian%3BRader%2C+Christoph%3BRaveche%2C+Elizabeth&rft.aulast=Salerno&rft.aufirst=Erica&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis and Antineoplastic Activity of Bis-diazeniumdiolate Analogues of the Nitric Oxide-generating Prodrug JS-K T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859817; 4822335 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Keefer, Larry K AU - Andrei, Daniela AU - Maciag, Anna AU - Chakrapani, Harinath AU - Citro, Michael L AU - Saavedra, Joseph E AU - Shami, Paul J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prodrugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Synthesis+and+Antineoplastic+Activity+of+Bis-diazeniumdiolate+Analogues+of+the+Nitric+Oxide-generating+Prodrug+JS-K&rft.au=Keefer%2C+Larry+K%3BAndrei%2C+Daniela%3BMaciag%2C+Anna%3BChakrapani%2C+Harinath%3BCitro%2C+Michael+L%3BSaavedra%2C+Joseph+E%3BShami%2C+Paul+J&rft.aulast=Keefer&rft.aufirst=Larry&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation in the Androgen Receptor Gene and Risk of Endometrial Cancer. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859662; 4824063 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Yang, Hannah AU - Garcia-Closas, Montserrat AU - Lacey Jr, James V AU - Brinton, Louise A AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Chanock, Stephen AU - Gaudet, Mia M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Genetic diversity KW - Androgen receptors KW - Endometrium KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genetic+Variation+in+the+Androgen+Receptor+Gene+and+Risk+of+Endometrial+Cancer.&rft.au=Yang%2C+Hannah%3BGarcia-Closas%2C+Montserrat%3BLacey+Jr%2C+James+V%3BBrinton%2C+Louise+A%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BChanock%2C+Stephen%3BGaudet%2C+Mia+M&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Worsening Degree of Poverty Predicts Increased Likelihood of ER/PR Negative, Triple Negative and Basal Breast Cancer Subtypes. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859561; 4823368 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Dookeran, Keith A AU - Wang, Yu AU - Gao, Xuezhi AU - Ferrer, Karen AU - Sekosan, Marin AU - Song, Shiwen AU - Lukaszczyk, Barbara AU - Chang, Wei J AU - Gonzalez, Emmanuel AU - Rogowski, Wendy A AU - Radeke, Erika K AU - McCaskill-Stevens, Worta AU - Zaren, Howard A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Poverty KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Worsening+Degree+of+Poverty+Predicts+Increased+Likelihood+of+ER%2FPR+Negative%2C+Triple+Negative+and+Basal+Breast+Cancer+Subtypes.&rft.au=Dookeran%2C+Keith+A%3BWang%2C+Yu%3BGao%2C+Xuezhi%3BFerrer%2C+Karen%3BSekosan%2C+Marin%3BSong%2C+Shiwen%3BLukaszczyk%2C+Barbara%3BChang%2C+Wei+J%3BGonzalez%2C+Emmanuel%3BRogowski%2C+Wendy+A%3BRadeke%2C+Erika+K%3BMcCaskill-Stevens%2C+Worta%3BZaren%2C+Howard+A&rft.aulast=Dookeran&rft.aufirst=Keith&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Vascular and Tumor Cell Gene Silencing with Chitosan Nanoparticles in Ovarian Carcinoma T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40858688; 4822158 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Mangala, Lingegowda S AU - Han, Hee Dong AU - Lu, Chunhua AU - Ali-Fehmi, Rouba AU - Munkarah, Adnan AU - Spannuth, Whitney A AU - Armaiz-Pena, Guillermo AU - Nick, Alpa M AU - Lee, Jeong Won AU - Shahzad, Mian M AU - Ozturk, Eylem AU - Sanguino, Angela AU - Denkbas, Emir AU - Birrer, Michael J AU - Lopez-Berestein, Gabriel AU - Sood, Anil K Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Ovarian carcinoma KW - Tumor cells KW - Gene silencing KW - Vascular system KW - Nanoparticles KW - Chitosan KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=In+Vivo+Vascular+and+Tumor+Cell+Gene+Silencing+with+Chitosan+Nanoparticles+in+Ovarian+Carcinoma&rft.au=Mangala%2C+Lingegowda+S%3BHan%2C+Hee+Dong%3BLu%2C+Chunhua%3BAli-Fehmi%2C+Rouba%3BMunkarah%2C+Adnan%3BSpannuth%2C+Whitney+A%3BArmaiz-Pena%2C+Guillermo%3BNick%2C+Alpa+M%3BLee%2C+Jeong+Won%3BShahzad%2C+Mian+M%3BOzturk%2C+Eylem%3BSanguino%2C+Angela%3BDenkbas%2C+Emir%3BBirrer%2C+Michael+J%3BLopez-Berestein%2C+Gabriel%3BSood%2C+Anil+K&rft.aulast=Mangala&rft.aufirst=Lingegowda&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Pharmacological Evaluations of SMA-491, a Nucleoside Analogue Related to Sangivamycin. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40858631; 4822717 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Li, Mao AU - Wang, Wei AU - Rayburn, Elizabeth R AU - Wang, Hui AU - Hill, Donald L AU - Covey, Joseph M AU - Zhang, Ruiwen Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Nucleoside analogs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Preclinical+Pharmacological+Evaluations+of+SMA-491%2C+a+Nucleoside+Analogue+Related+to+Sangivamycin.&rft.au=Li%2C+Mao%3BWang%2C+Wei%3BRayburn%2C+Elizabeth+R%3BWang%2C+Hui%3BHill%2C+Donald+L%3BCovey%2C+Joseph+M%3BZhang%2C+Ruiwen&rft.aulast=Li&rft.aufirst=Mao&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epigenetic Reprogramming of Breast Cells at Early Age after DMBA Exposure T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40858472; 4819428 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Cheng, Yuk Sing R AU - Yeh, Grace C AU - Bennett, Michelle L Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Age KW - 9,10-Dimethyl-1,2-benzanthracene KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Epigenetic+Reprogramming+of+Breast+Cells+at+Early+Age+after+DMBA+Exposure&rft.au=Cheng%2C+Yuk+Sing+R%3BYeh%2C+Grace+C%3BBennett%2C+Michelle+L&rft.aulast=Cheng&rft.aufirst=Yuk+Sing&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - JS-K, a Nitric Oxide-Donating Prodrug, Inhibits the Growth of Human Colon Cancer Cells: Modulation of ss-Catenin/TCF Signaling. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40858451; 4822706 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Nath, Niharika AU - Fallon, Eleanor A AU - Patel, Arth M AU - Saavedra, Joseph E AU - Keefer, Larry K AU - Kashfi, Khosrow Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colon cancer KW - Signal transduction KW - Tcf protein KW - Prodrugs KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=JS-K%2C+a+Nitric+Oxide-Donating+Prodrug%2C+Inhibits+the+Growth+of+Human+Colon+Cancer+Cells%3A+Modulation+of+ss-Catenin%2FTCF+Signaling.&rft.au=Nath%2C+Niharika%3BFallon%2C+Eleanor+A%3BPatel%2C+Arth+M%3BSaavedra%2C+Joseph+E%3BKeefer%2C+Larry+K%3BKashfi%2C+Khosrow&rft.aulast=Nath&rft.aufirst=Niharika&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiles in Epithelial and Stromal Cells from Murine Mammary Tumors with different Hormone Dependence T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40858355; 4821158 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Giulianelli, Sebastian J AU - Herschkowitz, Jason I AU - Patel, Vyomesh AU - Molinolo, Alfredo A AU - Gutkind, Silvio AU - Perou, Charles M AU - Lanari, Claudia Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Hormones KW - Gene expression KW - Mammary gland KW - Tumors KW - Stromal cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Gene+Expression+Profiles+in+Epithelial+and+Stromal+Cells+from+Murine+Mammary+Tumors+with+different+Hormone+Dependence&rft.au=Giulianelli%2C+Sebastian+J%3BHerschkowitz%2C+Jason+I%3BPatel%2C+Vyomesh%3BMolinolo%2C+Alfredo+A%3BGutkind%2C+Silvio%3BPerou%2C+Charles+M%3BLanari%2C+Claudia&rft.aulast=Giulianelli&rft.aufirst=Sebastian&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppressor of Cytokine Signaling-1 (SOCS-1) Negatively Regulates Angiogenesis, Invasion, and Brain Metastasis of Melanoma Cells T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857853; 4822540 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Huang, Feng-Ju AU - Steeg, Patricia S AU - Price, Janet E AU - Sawaya, Raymond AU - Huang, Suyun Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Melanoma KW - Brain KW - Angiogenesis KW - Metastases KW - SOCS-1 protein KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Suppressor+of+Cytokine+Signaling-1+%28SOCS-1%29+Negatively+Regulates+Angiogenesis%2C+Invasion%2C+and+Brain+Metastasis+of+Melanoma+Cells&rft.au=Huang%2C+Feng-Ju%3BSteeg%2C+Patricia+S%3BPrice%2C+Janet+E%3BSawaya%2C+Raymond%3BHuang%2C+Suyun&rft.aulast=Huang&rft.aufirst=Feng-Ju&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor-stroma Interactions in Ovarian Cancer: The Role of CTGF in Ovarian Tumor Biology T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857818; 4822536 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Samimi, Goli AU - Bonome, Tomas AU - Ghosh, Sue AU - Ng, Shu-wing AU - Mok, Samuel C AU - Birrer, Michael J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Ovarian cancer KW - Tumors KW - Connective tissue growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tumor-stroma+Interactions+in+Ovarian+Cancer%3A+The+Role+of+CTGF+in+Ovarian+Tumor+Biology&rft.au=Samimi%2C+Goli%3BBonome%2C+Tomas%3BGhosh%2C+Sue%3BNg%2C+Shu-wing%3BMok%2C+Samuel+C%3BBirrer%2C+Michael+J&rft.aulast=Samimi&rft.aufirst=Goli&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling Reveals Tumor Immunobiological Differences in Prostate Cancer between African-American and European-American Men T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857657; 4819964 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wallace, Tiffany A AU - Prueitt, Robyn L AU - Yi, Ming AU - Stephens, Robert M AU - Ambs, Stefan Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Africa KW - Prostate cancer KW - Gene expression KW - Tumors KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Gene+Expression+Profiling+Reveals+Tumor+Immunobiological+Differences+in+Prostate+Cancer+between+African-American+and+European-American+Men&rft.au=Wallace%2C+Tiffany+A%3BPrueitt%2C+Robyn+L%3BYi%2C+Ming%3BStephens%2C+Robert+M%3BAmbs%2C+Stefan&rft.aulast=Wallace&rft.aufirst=Tiffany&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defining the Role of Endoglin/ Smad1 Signaling in Modulating TGF-beta/Smad3 Function during Breast Cancer Progression. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857631; 4821204 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kamaraju, Anil K AU - Byfield, Stacey Dacosta AU - Roberts, Anita B AU - Wakefield, Lalage M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - Signal transduction KW - Endoglin KW - Transforming growth factor-b KW - Smad3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Defining+the+Role+of+Endoglin%2F+Smad1+Signaling+in+Modulating+TGF-beta%2FSmad3+Function+during+Breast+Cancer+Progression.&rft.au=Kamaraju%2C+Anil+K%3BByfield%2C+Stacey+Dacosta%3BRoberts%2C+Anita+B%3BWakefield%2C+Lalage+M&rft.aulast=Kamaraju&rft.aufirst=Anil&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling of EWS/FLI-1 Expressing Human Mesenchymal Pluripotent Cells Reveals Similarities to Ewing's Sarcoma Cell Lines and Tumors. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857420; 4823879 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Currier, Duane AU - Chen, Qingrong AU - Krishnan, Kartik AU - Haleem-Smith, Hanna AU - Tuan, Rocky AU - Khan, Javed AU - Helman, Lee AU - Khanna, Chand Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Gene expression KW - Sarcoma KW - FLI-1 protein KW - Tumors KW - Tumor cell lines KW - Mesenchyme KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Gene+Expression+Profiling+of+EWS%2FFLI-1+Expressing+Human+Mesenchymal+Pluripotent+Cells+Reveals+Similarities+to+Ewing%27s+Sarcoma+Cell+Lines+and+Tumors.&rft.au=Currier%2C+Duane%3BChen%2C+Qingrong%3BKrishnan%2C+Kartik%3BHaleem-Smith%2C+Hanna%3BTuan%2C+Rocky%3BKhan%2C+Javed%3BHelman%2C+Lee%3BKhanna%2C+Chand&rft.aulast=Currier&rft.aufirst=Duane&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Breast Cancer Risk Factors by Tumor Marker Status: A Population-Based Analysis Using Classification Trees T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857151; 4819765 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Sherman, Mark AU - Pfeiffer, Ruth AU - Cartun, Richard AU - Rimm, David AU - Yang, Rose AU - Peplonska, Beata AU - Lissowska, Jolanta AU - Brinton, Louise AU - Garcia-Closas, Montserrat Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - Trees KW - Tumor markers KW - Classification KW - Risk factors KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Breast+Cancer+Risk+Factors+by+Tumor+Marker+Status%3A+A+Population-Based+Analysis+Using+Classification+Trees&rft.au=Sherman%2C+Mark%3BPfeiffer%2C+Ruth%3BCartun%2C+Richard%3BRimm%2C+David%3BYang%2C+Rose%3BPeplonska%2C+Beata%3BLissowska%2C+Jolanta%3BBrinton%2C+Louise%3BGarcia-Closas%2C+Montserrat&rft.aulast=Sherman&rft.aufirst=Mark&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Pluronic@@uRG@ Micelle Formulation Increases the Anti-Leukemic Activity of the Novel Anti-Cancer Nitric Oxide Prodrug JS-K. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857080; 4822704 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Shami, Paul J AU - Kosak, Ken M AU - Saavedra, Joseph E AU - Keefer, Larry K Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Nitric oxide KW - Prodrugs KW - Micelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+Pluronic%40%40uRG%40+Micelle+Formulation+Increases+the+Anti-Leukemic+Activity+of+the+Novel+Anti-Cancer+Nitric+Oxide+Prodrug+JS-K.&rft.au=Shami%2C+Paul+J%3BKosak%2C+Ken+M%3BSaavedra%2C+Joseph+E%3BKeefer%2C+Larry+K&rft.aulast=Shami&rft.aufirst=Paul&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857011; 4822377 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Rubenstein, Allan E AU - Chen, Ruihong AU - Yu, Jin-Chen AU - Shen, Xiaodong AU - Winssinger, Nicholas AU - Neckers, Len AU - Tsutsumi, Shinji AU - Beebe, Kristin Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Hsp90 protein KW - Heat shock proteins KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+Novel+Small+Molecule+Inhibitor+of+Heat+Shock+Protein+90+%28Hsp90%29&rft.au=Rubenstein%2C+Allan+E%3BChen%2C+Ruihong%3BYu%2C+Jin-Chen%3BShen%2C+Xiaodong%3BWinssinger%2C+Nicholas%3BNeckers%2C+Len%3BTsutsumi%2C+Shinji%3BBeebe%2C+Kristin&rft.aulast=Rubenstein&rft.aufirst=Allan&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro and In Vivo Efficacy and Toxicity Comparison between ApoGossypol and Gossypol, Bcl-2 Antagonists. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856789; 4823934 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kitada, Shinichi AU - Wei, Jun AU - Kress, Christina L AU - Zhai, Dayong AU - Krajewska, Maryla AU - Jia, Lee AU - Pellecchia, Maurizio AU - Reed, John C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Toxicity KW - Bcl-2 protein KW - Gossypol KW - Antagonists KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=In+Vitro+and+In+Vivo+Efficacy+and+Toxicity+Comparison+between+ApoGossypol+and+Gossypol%2C+Bcl-2+Antagonists.&rft.au=Kitada%2C+Shinichi%3BWei%2C+Jun%3BKress%2C+Christina+L%3BZhai%2C+Dayong%3BKrajewska%2C+Maryla%3BJia%2C+Lee%3BPellecchia%2C+Maurizio%3BReed%2C+John+C&rft.aulast=Kitada&rft.aufirst=Shinichi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphisms in the Adenomatous Polyposis coli (APC) Gene and Advanced Colorectal Adenoma. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856718; 4822617 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wong, Hui-Lee AU - Peters, Ulrike AU - Hayes, Richard B AU - Huang, Wen-Yi AU - Schatzkin, Arthur AU - Bresalier, Robert S AU - Velie, Ellen M AU - Brody, Lawrence C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colorectal cancer KW - Adenoma KW - Gene polymorphism KW - Adenomatous polyposis coli protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Polymorphisms+in+the+Adenomatous+Polyposis+coli+%28APC%29+Gene+and+Advanced+Colorectal+Adenoma.&rft.au=Wong%2C+Hui-Lee%3BPeters%2C+Ulrike%3BHayes%2C+Richard+B%3BHuang%2C+Wen-Yi%3BSchatzkin%2C+Arthur%3BBresalier%2C+Robert+S%3BVelie%2C+Ellen+M%3BBrody%2C+Lawrence+C&rft.aulast=Wong&rft.aufirst=Hui-Lee&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cisplatin Markedly Enhances Microtubule Depolymerization in A549 Cell Line Compared with Oxaliplatin. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856387; 4822648 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Min, Young Joo AU - Poruchynsky, Marianne S AU - Sackett, Dan L AU - Murphy, Bob AU - Fojo, Tito Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cisplatin KW - Oxaliplatin KW - Depolymerization KW - Microtubules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cisplatin+Markedly+Enhances+Microtubule+Depolymerization+in+A549+Cell+Line+Compared+with+Oxaliplatin.&rft.au=Min%2C+Young+Joo%3BPoruchynsky%2C+Marianne+S%3BSackett%2C+Dan+L%3BMurphy%2C+Bob%3BFojo%2C+Tito&rft.aulast=Min&rft.aufirst=Young&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reversal of ABCB1- and ABCG2-Mediated MDR by Erlotinib (Tarceva, OSI-774). T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856286; 4822741 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Shi, Zhi AU - Peng, Xing-Xiang AU - Kim, In-Wha AU - Shukla, Suneet AU - Si, Qiu-Sheng AU - Robey, Robert W AU - Bates, Susan E AU - Wang, Si-Rong AU - Chim, Christine AU - Shen, Tong AU - Tiwari, Amit AU - Ashby Jr, Charles R AU - Fu, Liwu AU - Ambudkar, Suresh V AU - Chen, Zhe-Sheng Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Drug resistance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Reversal+of+ABCB1-+and+ABCG2-Mediated+MDR+by+Erlotinib+%28Tarceva%2C+OSI-774%29.&rft.au=Shi%2C+Zhi%3BPeng%2C+Xing-Xiang%3BKim%2C+In-Wha%3BShukla%2C+Suneet%3BSi%2C+Qiu-Sheng%3BRobey%2C+Robert+W%3BBates%2C+Susan+E%3BWang%2C+Si-Rong%3BChim%2C+Christine%3BShen%2C+Tong%3BTiwari%2C+Amit%3BAshby+Jr%2C+Charles+R%3BFu%2C+Liwu%3BAmbudkar%2C+Suresh+V%3BChen%2C+Zhe-Sheng&rft.aulast=Shi&rft.aufirst=Zhi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vitamin E Intake, a-Tocopherol Status, and Pancreatic Cancer in a Cohort of Male Smokers. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856279; 4822604 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Stolzenberg-Solomon, Rachael Z AU - Scheffler-Collins, Seth AU - Weinstein, Stephanie AU - Garabrant, David H AU - Mannisto, Satu AU - Taylor, Philip AU - Virtamo, Jarmo AU - Albanes, Demetrius Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pancreatic cancer KW - Vitamin E KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Vitamin+E+Intake%2C+a-Tocopherol+Status%2C+and+Pancreatic+Cancer+in+a+Cohort+of+Male+Smokers.&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BScheffler-Collins%2C+Seth%3BWeinstein%2C+Stephanie%3BGarabrant%2C+David+H%3BMannisto%2C+Satu%3BTaylor%2C+Philip%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lapachenole: A Fluorescent Photoaffinity Probe for P-Glycoprotein (ABCB1). T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856244; 4822726 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Sauna, Zuben E AU - Cuenca, Luciann L AU - Nandigama, Krishnamachary AU - Ambudkar, Suresh V Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - P-Glycoprotein KW - Fluorescent indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Lapachenole%3A+A+Fluorescent+Photoaffinity+Probe+for+P-Glycoprotein+%28ABCB1%29.&rft.au=Sauna%2C+Zuben+E%3BCuenca%2C+Luciann+L%3BNandigama%2C+Krishnamachary%3BAmbudkar%2C+Suresh+V&rft.aulast=Sauna&rft.aufirst=Zuben&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Beta-Catenin Mutation Status on MDR1/P-Glycoprotein Expression and Chemotherapy Response in Colon Cancer Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856208; 4822722 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Stein, Ulrike S AU - Fleuter, Claudia AU - Shoemaker, Robert H AU - Schlag, Peter M AU - Walther, Wolfgang Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colon cancer KW - Chemotherapy KW - Mutation KW - P-Glycoprotein KW - Catenin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Impact+of+Beta-Catenin+Mutation+Status+on+MDR1%2FP-Glycoprotein+Expression+and+Chemotherapy+Response+in+Colon+Cancer+Cells.&rft.au=Stein%2C+Ulrike+S%3BFleuter%2C+Claudia%3BShoemaker%2C+Robert+H%3BSchlag%2C+Peter+M%3BWalther%2C+Wolfgang&rft.aulast=Stein&rft.aufirst=Ulrike&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Dose Toxicity of 6-Aminonicotinamide (6-AN, NSC-21206), Methylmercaptopurineriboside (6-MMPR, NSC-40774), and L-Aspartic Acid-N-Phosphonoacetyl Disodiumsalt (PALA, NSC-224131) in Beagle Dogs. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856129; 4823892 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Tosca, Patricia J AU - Merrill, John W AU - Vasconcelos, Daphne AU - Ryan, Michael J AU - Johnson, Jerry D AU - Rizvi, Naiyer AU - Schweikart, Karen AU - Tomaszewski, Joseph E Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - India, Uttar Pradesh, Palas KW - Toxicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Single+Dose+Toxicity+of+6-Aminonicotinamide+%286-AN%2C+NSC-21206%29%2C+Methylmercaptopurineriboside+%286-MMPR%2C+NSC-40774%29%2C+and+L-Aspartic+Acid-N-Phosphonoacetyl+Disodiumsalt+%28PALA%2C+NSC-224131%29+in+Beagle+Dogs.&rft.au=Tosca%2C+Patricia+J%3BMerrill%2C+John+W%3BVasconcelos%2C+Daphne%3BRyan%2C+Michael+J%3BJohnson%2C+Jerry+D%3BRizvi%2C+Naiyer%3BSchweikart%2C+Karen%3BTomaszewski%2C+Joseph+E&rft.aulast=Tosca&rft.aufirst=Patricia&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Family History of Cancer and Family History of Smoking in Lung Cancer Risk by Histology. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856078; 4822643 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gao, Ying AU - Goldstein, Alisa AU - Consonni, Dario AU - Caporaso, Neil AU - Goldin, Lynn AU - Landi, Maria Teresa Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Genetics KW - Lung cancer KW - Smoking KW - Histology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Family+History+of+Cancer+and+Family+History+of+Smoking+in+Lung+Cancer+Risk+by+Histology.&rft.au=Gao%2C+Ying%3BGoldstein%2C+Alisa%3BConsonni%2C+Dario%3BCaporaso%2C+Neil%3BGoldin%2C+Lynn%3BLandi%2C+Maria+Teresa&rft.aulast=Gao&rft.aufirst=Ying&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathway-Based Approach of Genetic Variation in the Vitamin D-Related Genes, Serum Vitamin D Concentrations, and Prostate Cancer Risk. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855993; 4822629 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Ahn, Jiyoung AU - Albanes, Demetrius AU - Peters, Ulrike AU - Berndt, Sonja I AU - Freedman, Neal D AU - Huang, Wen-Yi AU - Chatterjee, Nilanjan AU - Andriole, Gerald L AU - Chanock, Stephen AU - Schatzkin, Arthur AU - Hayes, Richard B Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Vitamin D KW - Prostate cancer KW - Genetic diversity KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Pathway-Based+Approach+of+Genetic+Variation+in+the+Vitamin+D-Related+Genes%2C+Serum+Vitamin+D+Concentrations%2C+and+Prostate+Cancer+Risk.&rft.au=Ahn%2C+Jiyoung%3BAlbanes%2C+Demetrius%3BPeters%2C+Ulrike%3BBerndt%2C+Sonja+I%3BFreedman%2C+Neal+D%3BHuang%2C+Wen-Yi%3BChatterjee%2C+Nilanjan%3BAndriole%2C+Gerald+L%3BChanock%2C+Stephen%3BSchatzkin%2C+Arthur%3BHayes%2C+Richard+B&rft.aulast=Ahn&rft.aufirst=Jiyoung&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stem Cells from the Hair Follicle Bulge Contribute to Skin Tumor Formation T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855963; 4822489 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Li, Shulan AU - Park, Heui-Joon AU - Trempus, Carol AU - Cotsarelis, George AU - Morris, Rebecca J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Stem cells KW - Skin KW - Hair KW - Tumors KW - Follicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Stem+Cells+from+the+Hair+Follicle+Bulge+Contribute+to+Skin+Tumor+Formation&rft.au=Li%2C+Shulan%3BPark%2C+Heui-Joon%3BTrempus%2C+Carol%3BCotsarelis%2C+George%3BMorris%2C+Rebecca+J&rft.aulast=Li&rft.aufirst=Shulan&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetics, Tissue Distribution, and Excretion of GGTI-2418, an Inhibitor of Geranylgeranyl Transferase I, in Mice. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855617; 4822716 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Noker, Patricia E AU - Coward, Lori AU - Gorman, Gregory S AU - Jia, Lee Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Excretion KW - Mice KW - Pharmacokinetics KW - Transferases KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Pharmacokinetics%2C+Tissue+Distribution%2C+and+Excretion+of+GGTI-2418%2C+an+Inhibitor+of+Geranylgeranyl+Transferase+I%2C+in+Mice.&rft.au=Noker%2C+Patricia+E%3BCoward%2C+Lori%3BGorman%2C+Gregory+S%3BJia%2C+Lee&rft.aulast=Noker&rft.aufirst=Patricia&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokeratin-RNA Crosslinking Mediated by the Antitumor Aminoflavone, NSC 686288. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855534; 4822694 DE: JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Meng, Lingua AU - Meng, Zhaojing AU - Miao, Ze-hong AU - Veenstra, Timothy D AU - Pommier, Yves Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cytokeratin-RNA+Crosslinking+Mediated+by+the+Antitumor+Aminoflavone%2C+NSC+686288.&rft.au=Meng%2C+Lingua%3BMeng%2C+Zhaojing%3BMiao%2C+Ze-hong%3BVeenstra%2C+Timothy+D%3BPommier%2C+Yves&rft.aulast=Meng&rft.aufirst=Lingua&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intake of Quercetin and Isothiocyanates and Risk of Lung Cancer: A Population-Based Case-Control Study. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855336; 4822600 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Lam, Tram K AU - Rotunno, Melissa AU - Randi, Giorgia AU - Bagnardi, Vincenzo AU - Subar, Amy F AU - Landi, Maria Teresa Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Quercetin KW - Isothiocyanate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Intake+of+Quercetin+and+Isothiocyanates+and+Risk+of+Lung+Cancer%3A+A+Population-Based+Case-Control+Study.&rft.au=Lam%2C+Tram+K%3BRotunno%2C+Melissa%3BRandi%2C+Giorgia%3BBagnardi%2C+Vincenzo%3BSubar%2C+Amy+F%3BLandi%2C+Maria+Teresa&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis and Studies of Structural Analogs of JS-K, an Anticancer Lead Compound T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855263; 4820358 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Keefer, Larry K AU - Chakrapani, Hari AU - Maciag, Anna AU - Kalathur, Ravi C AU - Citro, Michael L AU - Ji, Xinhua AU - Saavedra, Joseph E AU - Shami, Paul J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lead compounds KW - Analogs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Synthesis+and+Studies+of+Structural+Analogs+of+JS-K%2C+an+Anticancer+Lead+Compound&rft.au=Keefer%2C+Larry+K%3BChakrapani%2C+Hari%3BMaciag%2C+Anna%3BKalathur%2C+Ravi+C%3BCitro%2C+Michael+L%3BJi%2C+Xinhua%3BSaavedra%2C+Joseph+E%3BShami%2C+Paul+J&rft.aulast=Keefer&rft.aufirst=Larry&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Urine Metabolic Profiles of Farnesoid X Receptor-null Mice Exhibiting Spontaneous Hepatocarcinogenesis Using Mass Spectrometry-Based Metabolomics T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855253; 4820485 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Tyburski, John B AU - Kim, Insook AU - Ahn, Sung-Hoon AU - Idle, Jeffrey R AU - Gonzalez, Frank J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Mice KW - Urine KW - Metabolomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Characterization+of+Urine+Metabolic+Profiles+of+Farnesoid+X+Receptor-null+Mice+Exhibiting+Spontaneous+Hepatocarcinogenesis+Using+Mass+Spectrometry-Based+Metabolomics&rft.au=Tyburski%2C+John+B%3BKim%2C+Insook%3BAhn%2C+Sung-Hoon%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Tyburski&rft.aufirst=John&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Immune Stimulation and Subsequent Waldenstrom Macroglobulinemia T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855073; 4819762 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Koshiol, Jill AU - Gridley, Gloria AU - Engels, Eric A AU - McMaster, Mary L AU - Landgren, Ola Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Macroglobulinemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Chronic+Immune+Stimulation+and+Subsequent+Waldenstrom+Macroglobulinemia&rft.au=Koshiol%2C+Jill%3BGridley%2C+Gloria%3BEngels%2C+Eric+A%3BMcMaster%2C+Mary+L%3BLandgren%2C+Ola&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Unified Approach and Sample Preparation Protocol for Proteomic and Genomic Profiling of Cervical Swabs to Identify Biomarkers for Cervical Cancer Screening T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854983; 4820419 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Brooks, Rebecca A AU - Malone, James P AU - Gross, Julia AU - Gilmore, Petra AU - Nguyen, Loan AU - Sheng, Feng AU - Wright, Jason D AU - Taylor, Nicholas AU - Zighelboim, Israel AU - Funk, Margo C AU - Huettner, Phyllis C AU - Gius, David AU - Crimmins, Dan L AU - Ladenson, Jack AU - Townsend, R Reid AU - Rader, Janet S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cervical cancer KW - Bioindicators KW - Cervix KW - Proteomics KW - Genomics KW - Biomarkers KW - Screening KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+Unified+Approach+and+Sample+Preparation+Protocol+for+Proteomic+and+Genomic+Profiling+of+Cervical+Swabs+to+Identify+Biomarkers+for+Cervical+Cancer+Screening&rft.au=Brooks%2C+Rebecca+A%3BMalone%2C+James+P%3BGross%2C+Julia%3BGilmore%2C+Petra%3BNguyen%2C+Loan%3BSheng%2C+Feng%3BWright%2C+Jason+D%3BTaylor%2C+Nicholas%3BZighelboim%2C+Israel%3BFunk%2C+Margo+C%3BHuettner%2C+Phyllis+C%3BGius%2C+David%3BCrimmins%2C+Dan+L%3BLadenson%2C+Jack%3BTownsend%2C+R+Reid%3BRader%2C+Janet+S&rft.aulast=Brooks&rft.aufirst=Rebecca&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Cancer Models Database (caMOD) Accommodates More Species and Provides Pre-clinical Trials Information T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854944; 4820326 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wagner, Ulrike AU - Pandya, Sima AU - Galvez, Jose AU - Hadfield, Jill AU - Marks, Cheryl AU - Tarnowski, Betty AU - Heiskanen, Mervi AU - Klemm, Juli Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Databases KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Enhanced+Cancer+Models+Database+%28caMOD%29+Accommodates+More+Species+and+Provides+Pre-clinical+Trials+Information&rft.au=Wagner%2C+Ulrike%3BPandya%2C+Sima%3BGalvez%2C+Jose%3BHadfield%2C+Jill%3BMarks%2C+Cheryl%3BTarnowski%2C+Betty%3BHeiskanen%2C+Mervi%3BKlemm%2C+Juli&rft.aulast=Wagner&rft.aufirst=Ulrike&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NCI-nature Pathway Interaction Database: An Authoritative Collection of Human Cell Signaling Pathways T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854912; 4820324 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Anthony, Kira AU - Krupa, Shiva AU - Buchoff, Jeffrey R AU - Day, Matthew AU - Hannay, Timo AU - Schaefer, Carl F Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Signal transduction KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+NCI-nature+Pathway+Interaction+Database%3A+An+Authoritative+Collection+of+Human+Cell+Signaling+Pathways&rft.au=Anthony%2C+Kira%3BKrupa%2C+Shiva%3BBuchoff%2C+Jeffrey+R%3BDay%2C+Matthew%3BHannay%2C+Timo%3BSchaefer%2C+Carl+F&rft.aulast=Anthony&rft.aufirst=Kira&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantification of HER2 Degradation Following 17-DMAG Treatment by PET Imaging T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854894; 4822002 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kramer-Marek, Gabriela AU - Kiesewetter, Dale O AU - Rodriguez, Yesenia AU - Capala, Jacek Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - ErbB-2 protein KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Quantification+of+HER2+Degradation+Following+17-DMAG+Treatment+by+PET+Imaging&rft.au=Kramer-Marek%2C+Gabriela%3BKiesewetter%2C+Dale+O%3BRodriguez%2C+Yesenia%3BCapala%2C+Jacek&rft.aulast=Kramer-Marek&rft.aufirst=Gabriela&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TRP Channel Gene Expression Correlates with Drug Resistance T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854855; 4819830 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Calcagno, Anna Maria AU - Chewning, Katherine J AU - Paria, Biman AU - Ambudkar, Indu S AU - Ambudkar, Suresh V Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Channels KW - Drug resistance KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=TRP+Channel+Gene+Expression+Correlates+with+Drug+Resistance&rft.au=Calcagno%2C+Anna+Maria%3BChewning%2C+Katherine+J%3BParia%2C+Biman%3BAmbudkar%2C+Indu+S%3BAmbudkar%2C+Suresh+V&rft.aulast=Calcagno&rft.aufirst=Anna&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tuberculosis and Lung Cancer in Xuanwei, China T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854781; 4819774 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Engels, Eric A AU - Shen, Min AU - Chapman, Robert S AU - Yu, Ying-Ying AU - He, Xingzhou AU - Lan, Qing Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - China, People's Rep. KW - Tuberculosis KW - Lung cancer KW - Mycobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tuberculosis+and+Lung+Cancer+in+Xuanwei%2C+China&rft.au=Engels%2C+Eric+A%3BShen%2C+Min%3BChapman%2C+Robert+S%3BYu%2C+Ying-Ying%3BHe%2C+Xingzhou%3BLan%2C+Qing&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glycemic Index, Glycemic Load, Available Carbohydrate and Risk of Pancreatic Cancer in the NIH-AARP Diet and Health Study. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854740; 4822593 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Jiao, Li AU - Flood, Andrew P AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Stolzenberg-Solomon, Rachael Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Pancreatic cancer KW - Carbohydrates KW - Diets KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Glycemic+Index%2C+Glycemic+Load%2C+Available+Carbohydrate+and+Risk+of+Pancreatic+Cancer+in+the+NIH-AARP+Diet+and+Health+Study.&rft.au=Jiao%2C+Li%3BFlood%2C+Andrew+P%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BStolzenberg-Solomon%2C+Rachael&rft.aulast=Jiao&rft.aufirst=Li&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Point-of-Care Microchip for Isolating Circulating Tumor Cells in Peripheral Blood T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854586; 4820187 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Nagrath, Sunitha AU - Sequist, Lecia AU - Maheswaran, Shyamala AU - Bell, Daphne W AU - Irimia, Daniel AU - Ulkus, Lindsey AU - Smith, Mathew R AU - Kwak, Eunice L AU - Digumarthy, Subba AU - Muzikansky, Alona AU - Ryan, Paula AU - Balis, Ulysses J AU - Tompkins, Ronald G AU - Haber, Daniel A AU - Toner, Mehmet Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Tumor cells KW - Peripheral blood KW - Microchips KW - Tumors KW - Blood circulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+Point-of-Care+Microchip+for+Isolating+Circulating+Tumor+Cells+in+Peripheral+Blood&rft.au=Nagrath%2C+Sunitha%3BSequist%2C+Lecia%3BMaheswaran%2C+Shyamala%3BBell%2C+Daphne+W%3BIrimia%2C+Daniel%3BUlkus%2C+Lindsey%3BSmith%2C+Mathew+R%3BKwak%2C+Eunice+L%3BDigumarthy%2C+Subba%3BMuzikansky%2C+Alona%3BRyan%2C+Paula%3BBalis%2C+Ulysses+J%3BTompkins%2C+Ronald+G%3BHaber%2C+Daniel+A%3BToner%2C+Mehmet&rft.aulast=Nagrath&rft.aufirst=Sunitha&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Celiac Disease in Individuals and Close Family Members and Patterns of Autoimmunity and Lymphoproliferative Neoplasms T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854472; 4819969 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gao, Ying AU - Linet, Martha AU - Gridley, Gloria AU - Mellemkjaer, Lene AU - Olsen, Jorgen AU - Hemminki, Kari AU - Goldin, Lynn AU - Landgren, Ola Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Autoimmune diseases KW - Celiac disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Celiac+Disease+in+Individuals+and+Close+Family+Members+and+Patterns+of+Autoimmunity+and+Lymphoproliferative+Neoplasms&rft.au=Gao%2C+Ying%3BLinet%2C+Martha%3BGridley%2C+Gloria%3BMellemkjaer%2C+Lene%3BOlsen%2C+Jorgen%3BHemminki%2C+Kari%3BGoldin%2C+Lynn%3BLandgren%2C+Ola&rft.aulast=Gao&rft.aufirst=Ying&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Resistance to Taxanes of BRCA2 Associated Breast Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854313; 4819914 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - De Soto III, Joseph A. AU - Deng, C-X Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - Taxanes KW - BRCA2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+Resistance+to+Taxanes+of+BRCA2+Associated+Breast+Cancer&rft.au=De+Soto+III%2C+Joseph+A.%3BDeng%2C+C-X&rft.aulast=De+Soto+III&rft.aufirst=Joseph&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Effects of Caliban/Sdccag1 on Growth of Human Lung Cancer Cells in a Mouse Model of Lung Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853983; 4820319 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Mortin, Mark A AU - Bi, Xiaolin AU - Kennison, James AU - Hursh, Deborah A AU - Bhattacharya, Bhaskar AU - Joshi, Bharat H AU - Puri, Raj Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Animal models KW - Growth rate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=In+Vivo+Effects+of+Caliban%2FSdccag1+on+Growth+of+Human+Lung+Cancer+Cells+in+a+Mouse+Model+of+Lung+Cancer&rft.au=Mortin%2C+Mark+A%3BBi%2C+Xiaolin%3BKennison%2C+James%3BHursh%2C+Deborah+A%3BBhattacharya%2C+Bhaskar%3BJoshi%2C+Bharat+H%3BPuri%2C+Raj&rft.aulast=Mortin&rft.aufirst=Mark&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphisms in Estrogen and Androgen Metabolizing Genes and the Risk of Gastric Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853918; 4819754 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Freedman, Neal D AU - Ahn, Jiyoung AU - Hou, Lifang AU - Lissowska, Jolanta AU - Zatonski, Witold AU - Yeager, Meredith AU - Chanock, Stephen J AU - Chow, Wong-Ho AU - Abnet, Christian C Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Gastric cancer KW - Estrogens KW - Gene polymorphism KW - Androgens KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Polymorphisms+in+Estrogen+and+Androgen+Metabolizing+Genes+and+the+Risk+of+Gastric+Cancer&rft.au=Freedman%2C+Neal+D%3BAhn%2C+Jiyoung%3BHou%2C+Lifang%3BLissowska%2C+Jolanta%3BZatonski%2C+Witold%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BChow%2C+Wong-Ho%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Levels of Carcinogenic Polycyclic Aromatic Hydrocarbons in Mate Drinks T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853888; 4822116 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kamangar, Farin AU - Schantz, Michele M AU - Abnet, Christian C AU - Fagundes, Renato B AU - Dawsey, Sanford M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Polycyclic aromatic hydrocarbons KW - Carcinogenicity KW - Beverages KW - Aromatic hydrocarbons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=High+Levels+of+Carcinogenic+Polycyclic+Aromatic+Hydrocarbons+in+Mate+Drinks&rft.au=Kamangar%2C+Farin%3BSchantz%2C+Michele+M%3BAbnet%2C+Christian+C%3BFagundes%2C+Renato+B%3BDawsey%2C+Sanford+M&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carcinogenic Potential of Tar-based Vaginal Douche Products and Cervical Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853748; 4822115 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Haverkos, Harry W AU - Boring, Daniel AU - Kruhlak, Naomi L AU - Matthews, Edwin J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cervical cancer KW - Carcinogenicity KW - Vagina KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Carcinogenic+Potential+of+Tar-based+Vaginal+Douche+Products+and+Cervical+Cancer&rft.au=Haverkos%2C+Harry+W%3BBoring%2C+Daniel%3BKruhlak%2C+Naomi+L%3BMatthews%2C+Edwin+J&rft.aulast=Haverkos&rft.aufirst=Harry&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Stromal Genes Resulting in Osteosarcoma Tumor Metastasis T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853452; 4820021 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kim, Su Young AU - Lum, Nicole AU - Briggs, Joseph AU - Currier, Duane AU - Khanna, Chand AU - Munroe, David AU - Helman, Lee J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Tumors KW - Osteosarcoma KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Identification+of+Stromal+Genes+Resulting+in+Osteosarcoma+Tumor+Metastasis&rft.au=Kim%2C+Su+Young%3BLum%2C+Nicole%3BBriggs%2C+Joseph%3BCurrier%2C+Duane%3BKhanna%2C+Chand%3BMunroe%2C+David%3BHelman%2C+Lee+J&rft.aulast=Kim&rft.aufirst=Su&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TRMT12 Overexpression in Breast Cancer Cells and its Effect on the Wybutosine Biosynthetic Pathway T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853370; 4821925 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Rodriguez, Virginia W AU - Elkahloun, Abdel AU - Green, Jeffrey AU - Chandrasekharappa, Settara Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=TRMT12+Overexpression+in+Breast+Cancer+Cells+and+its+Effect+on+the+Wybutosine+Biosynthetic+Pathway&rft.au=Rodriguez%2C+Virginia+W%3BElkahloun%2C+Abdel%3BGreen%2C+Jeffrey%3BChandrasekharappa%2C+Settara&rft.aulast=Rodriguez&rft.aufirst=Virginia&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Ex Vivo Lung Organ Culture Assay to Study Pulmonary Metastases T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853261; 4820099 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Khan, Mohammed Ali AU - Mendoza, Arnulfo AU - Hong, Sung-Hyeok AU - Ren, Ling AU - Hunter, Kent AU - Wakefield, Lalage AU - Khanna, Chand Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Organs KW - Lung KW - Organ culture KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=An+Ex+Vivo+Lung+Organ+Culture+Assay+to+Study+Pulmonary+Metastases&rft.au=Khan%2C+Mohammed+Ali%3BMendoza%2C+Arnulfo%3BHong%2C+Sung-Hyeok%3BRen%2C+Ling%3BHunter%2C+Kent%3BWakefield%2C+Lalage%3BKhanna%2C+Chand&rft.aulast=Khan&rft.aufirst=Mohammed&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Expression of Antioxidant Response Element Target Genes in Bronchial Epithelial Cells of Smokers with Lung Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852803; 4820340 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wang, Xuting AU - Shah, Vishal AU - Pittman, Gary S AU - Chorley, Brian N AU - Liu, Gang AU - Brody, Jerome S AU - Kleeberger, Steven R AU - Spira, Avrum AU - Bell, Douglas A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Antioxidants KW - Regulatory sequences KW - Epithelial cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Altered+Expression+of+Antioxidant+Response+Element+Target+Genes+in+Bronchial+Epithelial+Cells+of+Smokers+with+Lung+Cancer&rft.au=Wang%2C+Xuting%3BShah%2C+Vishal%3BPittman%2C+Gary+S%3BChorley%2C+Brian+N%3BLiu%2C+Gang%3BBrody%2C+Jerome+S%3BKleeberger%2C+Steven+R%3BSpira%2C+Avrum%3BBell%2C+Douglas+A&rft.aulast=Wang&rft.aufirst=Xuting&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antitumor Effects of Sorafenib, Bevacizumab and Cetuximab as Single Agents or in Combination with an MEK, mTOR or Bcl-2 Inhibitor, in a SNU-398 Human Hepatocellular Tumor Xenograft Model. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852790; 4820624 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Rodon, Jordi AU - Malik, Gunjan AU - Wu, Wang-Hong AU - Sankhala, Kamalesh AU - Wick, Michael J AU - Dancey, Janet AU - Papadoupolos, Kyriakos Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Xenografts KW - Bcl-2 protein KW - Antitumor activity KW - Tumors KW - Bevacizumab KW - Models KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Antitumor+Effects+of+Sorafenib%2C+Bevacizumab+and+Cetuximab+as+Single+Agents+or+in+Combination+with+an+MEK%2C+mTOR+or+Bcl-2+Inhibitor%2C+in+a+SNU-398+Human+Hepatocellular+Tumor+Xenograft+Model.&rft.au=Rodon%2C+Jordi%3BMalik%2C+Gunjan%3BWu%2C+Wang-Hong%3BSankhala%2C+Kamalesh%3BWick%2C+Michael+J%3BDancey%2C+Janet%3BPapadoupolos%2C+Kyriakos&rft.aulast=Rodon&rft.aufirst=Jordi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overcoming Imatinib Resistance Using CAI, a Calcium-mediated Signal Transduction Inhibitor: A New Therapeutic Strategy for Chronic Myelogenous Leukaemia T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852445; 4822041 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Corrado, Chiara AU - Fontana, Simona AU - Giordano, Margherita AU - Colomba, Paolo AU - Raimondo, Stefania AU - Arlinghaus, Ralph B AU - Kohn, Elise C AU - De Leo, Giacomo AU - Alessandro, Riccardo Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Chronic myeloid leukemia KW - Signal transduction KW - Inhibitors KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Overcoming+Imatinib+Resistance+Using+CAI%2C+a+Calcium-mediated+Signal+Transduction+Inhibitor%3A+A+New+Therapeutic+Strategy+for+Chronic+Myelogenous+Leukaemia&rft.au=Corrado%2C+Chiara%3BFontana%2C+Simona%3BGiordano%2C+Margherita%3BColomba%2C+Paolo%3BRaimondo%2C+Stefania%3BArlinghaus%2C+Ralph+B%3BKohn%2C+Elise+C%3BDe+Leo%2C+Giacomo%3BAlessandro%2C+Riccardo&rft.aulast=Corrado&rft.aufirst=Chiara&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transforming Growth Factor-beta Gene Expression Signature Predicts Clinical Outcome in Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852440; 4820257 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Coulouarn, Cedric AU - Factor, Valentina M AU - Thorgeirsson, Snorri S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Gene expression KW - Transforming growth factor-b KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Transforming+Growth+Factor-beta+Gene+Expression+Signature+Predicts+Clinical+Outcome+in+Cancer&rft.au=Coulouarn%2C+Cedric%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Coulouarn&rft.aufirst=Cedric&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting HER1 and HER2 Using @@u86@Y-CHX-A" Labeled Cetuximab and Trastuzumab for PET Imaging T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852437; 4821982 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Regino, Celeste A.S. AU - Milenic, Diane E AU - Wong, Karen J AU - Garmestani, Kayhan AU - Baidoo, Kwamena AU - Williams, Mark AU - Seidel, Jurgen AU - Green, Michael AU - Choyke, Peter L AU - Brechbiel, Martin W Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - ErbB-2 protein KW - Trastuzumab KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Targeting+HER1+and+HER2+Using+%40%40u86%40Y-CHX-A%22+Labeled+Cetuximab+and+Trastuzumab+for+PET+Imaging&rft.au=Regino%2C+Celeste+A.S.%3BMilenic%2C+Diane+E%3BWong%2C+Karen+J%3BGarmestani%2C+Kayhan%3BBaidoo%2C+Kwamena%3BWilliams%2C+Mark%3BSeidel%2C+Jurgen%3BGreen%2C+Michael%3BChoyke%2C+Peter+L%3BBrechbiel%2C+Martin+W&rft.aulast=Regino&rft.aufirst=Celeste&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic DNA Hypomethylation is a Biomarker for Bladder Cancer Susceptibility T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40851849; 4821757 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Moore, Lee E AU - Pfeiffer, Ruth AU - Poscablo, Cristina AU - Real, Francisco AU - Kogevinas, Manolis AU - Silverman, Debra AU - Garcia-Closas, Reina AU - Chanock, Stephen AU - Tardon, Adnonina AU - Rothman, Nathaniel AU - Serra, Consol AU - Carrato, Alfredo AU - Dosemeci, Mustafa AU - Garcia-Closas, Monsterrat AU - Esteller, Manel AU - Fraga, Mario AU - Malats, Nuria Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Bioindicators KW - Urinary bladder KW - Genomics KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40851849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genomic+DNA+Hypomethylation+is+a+Biomarker+for+Bladder+Cancer+Susceptibility&rft.au=Moore%2C+Lee+E%3BPfeiffer%2C+Ruth%3BPoscablo%2C+Cristina%3BReal%2C+Francisco%3BKogevinas%2C+Manolis%3BSilverman%2C+Debra%3BGarcia-Closas%2C+Reina%3BChanock%2C+Stephen%3BTardon%2C+Adnonina%3BRothman%2C+Nathaniel%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BDosemeci%2C+Mustafa%3BGarcia-Closas%2C+Monsterrat%3BEsteller%2C+Manel%3BFraga%2C+Mario%3BMalats%2C+Nuria&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Histone h4 Acetylation and hdac2 Expression Correlate with the Progression of Colon Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40851579; 4821779 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Belgrave, Kevin AU - Takikita, Mikiko AU - Naab, Tammy AU - Lee, Edward L AU - Nouraie, Mehdi AU - Hewitt, Stephen M AU - Smoot, Duane T AU - Green, William AU - Ashktorab, Hassan Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colon cancer KW - Acetylation KW - Histone deacetylase KW - HDAC2 protein KW - Histone H4 KW - Histones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40851579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Global+Histone+h4+Acetylation+and+hdac2+Expression+Correlate+with+the+Progression+of+Colon+Cancer&rft.au=Belgrave%2C+Kevin%3BTakikita%2C+Mikiko%3BNaab%2C+Tammy%3BLee%2C+Edward+L%3BNouraie%2C+Mehdi%3BHewitt%2C+Stephen+M%3BSmoot%2C+Duane+T%3BGreen%2C+William%3BAshktorab%2C+Hassan&rft.aulast=Belgrave&rft.aufirst=Kevin&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling of Prostate Cancer Cells after Single and Fractionated Doses of Radiation T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40850788; 4820645 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Aryankalayil, Molykutty J AU - Palayoor, Sanjeewani T AU - Cerna, David AU - Coleman, C Norman Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Gene expression KW - Radiation KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40850788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Gene+Expression+Profiling+of+Prostate+Cancer+Cells+after+Single+and+Fractionated+Doses+of+Radiation&rft.au=Aryankalayil%2C+Molykutty+J%3BPalayoor%2C+Sanjeewani+T%3BCerna%2C+David%3BColeman%2C+C+Norman&rft.aulast=Aryankalayil&rft.aufirst=Molykutty&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Anti-proliferative Activity of an IGF1R Antibody is Correlated with IGF1R Level and Associated with the Inhibition of AKT Pathway in Rhabdomyosarcoma T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40849375; 4820665 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Cao, Liang AU - Yu, Yunkai AU - Darko, Isaac AU - Currier, Duane AU - Khanna, Chand AU - Helman, Lee Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Rhabdomyosarcoma KW - Antibodies KW - AKT protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40849375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+Anti-proliferative+Activity+of+an+IGF1R+Antibody+is+Correlated+with+IGF1R+Level+and+Associated+with+the+Inhibition+of+AKT+Pathway+in+Rhabdomyosarcoma&rft.au=Cao%2C+Liang%3BYu%2C+Yunkai%3BDarko%2C+Isaac%3BCurrier%2C+Duane%3BKhanna%2C+Chand%3BHelman%2C+Lee&rft.aulast=Cao&rft.aufirst=Liang&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intergenic Non-Coding RNA Inhibits 45S rRNA Processing and Induces Lung Cancer Cell Death T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40847696; 4819561 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Shiao, Yih-Horng AU - Gu, Yuhan AU - Lupascu, Sorin T AU - Fields, Janet R AU - Anderson, Lucy M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Mortality KW - Lung cancer KW - RRNA 45S KW - Non-coding RNA KW - Cell death KW - RNA processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40847696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Intergenic+Non-Coding+RNA+Inhibits+45S+rRNA+Processing+and+Induces+Lung+Cancer+Cell+Death&rft.au=Shiao%2C+Yih-Horng%3BGu%2C+Yuhan%3BLupascu%2C+Sorin+T%3BFields%2C+Janet+R%3BAnderson%2C+Lucy+M&rft.aulast=Shiao&rft.aufirst=Yih-Horng&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER -