TY - CPAPER T1 - The MYCN Oncogene is a Direct Target of miR-34a. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40873735; 4824540 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wei, Jun S AU - Song, Young K AU - Durinck, Steffen AU - Chen, Qing-Rong AU - Cheuk, Adam Tai Chi AU - Zhang, Quangeng AU - Thiele, Carol J AU - Slack, Andrew AU - Shohet, Jason AU - Khan, Javed Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Oncogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+MYCN+Oncogene+is+a+Direct+Target+of+miR-34a.&rft.au=Wei%2C+Jun+S%3BSong%2C+Young+K%3BDurinck%2C+Steffen%3BChen%2C+Qing-Rong%3BCheuk%2C+Adam+Tai+Chi%3BZhang%2C+Quangeng%3BThiele%2C+Carol+J%3BSlack%2C+Andrew%3BShohet%2C+Jason%3BKhan%2C+Javed&rft.aulast=Wei&rft.aufirst=Jun&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of PDCD4 Tumor Suppressor Protein is Regulated Negatively by PI3K/Akt/mTOR and Positively PKC d Pathways in Breast Cancer Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40872970; 4824454 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Akar, Ugur AU - Ozpolat, Bulent AU - Colburn, Nancy AU - Yang, Hsin-Sheng AU - Berestein, Gabriel Lopez AU - Arun, Banu Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - 1-Phosphatidylinositol 3-kinase KW - AKT protein KW - Tumor suppressor genes KW - Protein kinase C KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40872970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Expression+of+PDCD4+Tumor+Suppressor+Protein+is+Regulated+Negatively+by+PI3K%2FAkt%2FmTOR+and+Positively+PKC+d+Pathways+in+Breast+Cancer+Cells.&rft.au=Akar%2C+Ugur%3BOzpolat%2C+Bulent%3BColburn%2C+Nancy%3BYang%2C+Hsin-Sheng%3BBerestein%2C+Gabriel+Lopez%3BArun%2C+Banu&rft.aulast=Akar&rft.aufirst=Ugur&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mitogenic Signaling Molecules Associated with the Effectiveness of Gefitinib (Iressa) in Treating Mammary Cancers in Rats. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40870665; 4823096 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Bode, Ann M AU - Grubbs, Clinton J AU - Lubet, Ronald A AU - Ericson, Marna E Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Rats KW - Signal transduction KW - Gefitinib KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40870665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Mitogenic+Signaling+Molecules+Associated+with+the+Effectiveness+of+Gefitinib+%28Iressa%29+in+Treating+Mammary+Cancers+in+Rats.&rft.au=Bode%2C+Ann+M%3BGrubbs%2C+Clinton+J%3BLubet%2C+Ronald+A%3BEricson%2C+Marna+E&rft.aulast=Bode&rft.aufirst=Ann&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Low-dose Metronomic Daily Cyclophosphamide is a Well-tolerated Regimen with Enhanced Efficacy in a Mouse Model of Prostate Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40867326; 4821543 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Ferretti, Gianluigi AU - Cardillo, Irene AU - Galluzzo, Paola AU - Spugnini, Enrico P AU - Citro, Gennaro AU - Carlini, Paolo AU - Boccardo, Francesco AU - Balbi, Cecilia AU - Ferrari, Nicoletta AU - Cognetti, Francesco AU - Ruggeri, Enzo M AU - Felici, Alessandra AU - Baldi, Alfonso Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Animal models KW - Cyclophosphamide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40867326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Low-dose+Metronomic+Daily+Cyclophosphamide+is+a+Well-tolerated+Regimen+with+Enhanced+Efficacy+in+a+Mouse+Model+of+Prostate+Cancer&rft.au=Ferretti%2C+Gianluigi%3BCardillo%2C+Irene%3BGalluzzo%2C+Paola%3BSpugnini%2C+Enrico+P%3BCitro%2C+Gennaro%3BCarlini%2C+Paolo%3BBoccardo%2C+Francesco%3BBalbi%2C+Cecilia%3BFerrari%2C+Nicoletta%3BCognetti%2C+Francesco%3BRuggeri%2C+Enzo+M%3BFelici%2C+Alessandra%3BBaldi%2C+Alfonso&rft.aulast=Ferretti&rft.aufirst=Gianluigi&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amphiregulin-induced Luminal Mammary Epithelial Differentiation is Stimulated by 2-methoxyestradiol and 17b-estradiol T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866484; 4820894 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Huh, Jung-Im AU - Qiu, Tinghu AU - Sato, Misako AU - Cataisson, Christophe AU - Michalowska, Aleksandra AU - Catena, Raul AU - Calvo, Alfonso AU - LaVallee, Theresa M AU - Tchou, Julia AU - Herlyn, Meenhard AU - Green, Jeffrey E Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Differentiation KW - 17b-Estradiol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Amphiregulin-induced+Luminal+Mammary+Epithelial+Differentiation+is+Stimulated+by+2-methoxyestradiol+and+17b-estradiol&rft.au=Huh%2C+Jung-Im%3BQiu%2C+Tinghu%3BSato%2C+Misako%3BCataisson%2C+Christophe%3BMichalowska%2C+Aleksandra%3BCatena%2C+Raul%3BCalvo%2C+Alfonso%3BLaVallee%2C+Theresa+M%3BTchou%2C+Julia%3BHerlyn%2C+Meenhard%3BGreen%2C+Jeffrey+E&rft.aulast=Huh&rft.aufirst=Jung-Im&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Dose Medroxyprogesterone Acetate (MPA) has Anti-angiogenic Properties. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40866099; 4820899 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Marshall, Jean-Claude A AU - Collins, Joshua W AU - Miller, Kathy D AU - Steeg, Patricia S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Medroxyprogesterone acetate KW - Acetic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=High+Dose+Medroxyprogesterone+Acetate+%28MPA%29+has+Anti-angiogenic+Properties.&rft.au=Marshall%2C+Jean-Claude+A%3BCollins%2C+Joshua+W%3BMiller%2C+Kathy+D%3BSteeg%2C+Patricia+S&rft.aulast=Marshall&rft.aufirst=Jean-Claude&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive Breast Cancer Signaling Network Analysis. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864962; 4823287 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Pierobon, Mariaelena AU - Calvert, Valerie S AU - Galdi, Francesca AU - Deng, Jahnhong AU - Wulfkuhle, Julia AU - Signore, Michele AU - Belluco, Claudio AU - Mammano, Enzo AU - Zavagno, Giorgio AU - Nitti, Donato AU - Liotta, Lance AU - Petricoin III, Emanuel F. Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Breast cancer KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comprehensive+Breast+Cancer+Signaling+Network+Analysis.&rft.au=Pierobon%2C+Mariaelena%3BCalvert%2C+Valerie+S%3BGaldi%2C+Francesca%3BDeng%2C+Jahnhong%3BWulfkuhle%2C+Julia%3BSignore%2C+Michele%3BBelluco%2C+Claudio%3BMammano%2C+Enzo%3BZavagno%2C+Giorgio%3BNitti%2C+Donato%3BLiotta%2C+Lance%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Pierobon&rft.aufirst=Mariaelena&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Xenograft Mouse Model of Human Skin Tumors in Tuberous Sclerosis Complex. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864708; 4822914 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Li, Shaowei AU - Wang, Ji-an AU - Rajesh, Sangeetha AU - Moss, Joel AU - Darling, Thomas Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Skin KW - Animal models KW - Xenografts KW - Tuberous sclerosis KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+Novel+Xenograft+Mouse+Model+of+Human+Skin+Tumors+in+Tuberous+Sclerosis+Complex.&rft.au=Li%2C+Shaowei%3BWang%2C+Ji-an%3BRajesh%2C+Sangeetha%3BMoss%2C+Joel%3BDarling%2C+Thomas&rft.aulast=Li&rft.aufirst=Shaowei&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Signatures of Epidermal Growth Factor Receptor and Survival Signal Pathways Correspond to Gefitinib Sensitivity in Head and Neck Cancer. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864513; 4824007 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Pernas, Francisco G AU - Allen, Clint T AU - Winters, Mary E AU - Dabir, Bhavana AU - Bagain, Lorena AU - Saigal, Kunal AU - Mundinger, Gerhardt S AU - Yan, Bin AU - Morris, John C AU - Calvo, Katherine R AU - Van Waes, Carter AU - Chen, Zhong Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Head and neck cancer KW - Survival KW - Growth factors KW - Proteomics KW - Gefitinib KW - Epidermal growth factor receptors KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Proteomic+Signatures+of+Epidermal+Growth+Factor+Receptor+and+Survival+Signal+Pathways+Correspond+to+Gefitinib+Sensitivity+in+Head+and+Neck+Cancer.&rft.au=Pernas%2C+Francisco+G%3BAllen%2C+Clint+T%3BWinters%2C+Mary+E%3BDabir%2C+Bhavana%3BBagain%2C+Lorena%3BSaigal%2C+Kunal%3BMundinger%2C+Gerhardt+S%3BYan%2C+Bin%3BMorris%2C+John+C%3BCalvo%2C+Katherine+R%3BVan+Waes%2C+Carter%3BChen%2C+Zhong&rft.aulast=Pernas&rft.aufirst=Francisco&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Responses of Five NO-NSAIDs in a Human Cell Melanoma Prevention Assay T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864356; 4820812 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Elmore, Eugene AU - Jain, Aarti AU - Steele, Vernon E AU - Redpath, J Leslie Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Melanoma KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comparative+Responses+of+Five+NO-NSAIDs+in+a+Human+Cell+Melanoma+Prevention+Assay&rft.au=Elmore%2C+Eugene%3BJain%2C+Aarti%3BSteele%2C+Vernon+E%3BRedpath%2C+J+Leslie&rft.aulast=Elmore&rft.aufirst=Eugene&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microbial Extract Containing Lactones Induces Apoptosis in Prostate Carcinoma Cells In Vitro. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40864239; 4822764 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Michelin, Ruel AU - Kinyua, Antony AU - Leitner, Wolfgang AU - Johnson, Cynthia AU - Todd III, Robert AU - Knox, Nathaniel AU - Shureiqi, Imad AU - Lobban, Kathleen AU - Whittaker, Joseph Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate carcinoma KW - Lactones KW - Apoptosis KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40864239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Microbial+Extract+Containing+Lactones+Induces+Apoptosis+in+Prostate+Carcinoma+Cells+In+Vitro.&rft.au=Michelin%2C+Ruel%3BKinyua%2C+Antony%3BLeitner%2C+Wolfgang%3BJohnson%2C+Cynthia%3BTodd+III%2C+Robert%3BKnox%2C+Nathaniel%3BShureiqi%2C+Imad%3BLobban%2C+Kathleen%3BWhittaker%2C+Joseph&rft.aulast=Michelin&rft.aufirst=Ruel&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Triple Combination of Treatments for Synergistic Cancer Cell Killing -Implication for a More Efficient Novel Cancer Treatment Principle. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863935; 4823536 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Yu, Ming AU - Van Waes, Carter Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Triple+Combination+of+Treatments+for+Synergistic+Cancer+Cell+Killing+-Implication+for+a+More+Efficient+Novel+Cancer+Treatment+Principle.&rft.au=Yu%2C+Ming%3BVan+Waes%2C+Carter&rft.aulast=Yu&rft.aufirst=Ming&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Multidrug Resistance Mechanisms in Ovarian Cancer. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863738; 4823335 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gillet, Jean-Pierre AU - Calcagno, Anna-Maria AU - Okabe, Mitsunori AU - Hall, Matthew D AU - Shen, Ding-Wu AU - Ambudkar, Suresh V AU - Gottesman, Michael M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Ovarian cancer KW - Multidrug resistance KW - Resistance mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Analysis+of+Multidrug+Resistance+Mechanisms+in+Ovarian+Cancer.&rft.au=Gillet%2C+Jean-Pierre%3BCalcagno%2C+Anna-Maria%3BOkabe%2C+Mitsunori%3BHall%2C+Matthew+D%3BShen%2C+Ding-Wu%3BAmbudkar%2C+Suresh+V%3BGottesman%2C+Michael+M&rft.aulast=Gillet&rft.aufirst=Jean-Pierre&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acral Lentiginous Melanoma: Incidence and Survival Patterns in the United States, 1986-2004. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863612; 4823383 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Bradford, Porcia T AU - Goldstein, Alisa M AU - McMaster, Mary L AU - Tucker, Margaret A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - USA KW - Melanoma KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Acral+Lentiginous+Melanoma%3A+Incidence+and+Survival+Patterns+in+the+United+States%2C+1986-2004.&rft.au=Bradford%2C+Porcia+T%3BGoldstein%2C+Alisa+M%3BMcMaster%2C+Mary+L%3BTucker%2C+Margaret+A&rft.aulast=Bradford&rft.aufirst=Porcia&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Family History and Upper Gastrointestinal Cancers in China. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863443; 4823410 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Gao, Ying AU - Hu, Nan AU - Han, Xiaoyou AU - Giffen, Carol AU - Ding, Ti AU - Goldstein, Alisa AU - Taylor, Philip R Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - China, People's Rep. KW - Cancer KW - Genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Family+History+and+Upper+Gastrointestinal+Cancers+in+China.&rft.au=Gao%2C+Ying%3BHu%2C+Nan%3BHan%2C+Xiaoyou%3BGiffen%2C+Carol%3BDing%2C+Ti%3BGoldstein%2C+Alisa%3BTaylor%2C+Philip+R&rft.aulast=Gao&rft.aufirst=Ying&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemopreventive Effects of Cucumaria frondosa Lipid Extract in Rat Colon Carcinogenesis and in a Human Colon Cancer Cell Line. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40863205; 4822851 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Janakiram, Naveena B AU - Zhang, Yuting AU - Choi, Chang-In AU - Mohammed, Altaf AU - Steele, Vernon E AU - Rao, Chinthalapally V Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Colon cancer KW - Lipids KW - Carcinogenesis KW - Tumor cell lines KW - Cucumaria frondosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40863205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Chemopreventive+Effects+of+Cucumaria+frondosa+Lipid+Extract+in+Rat+Colon+Carcinogenesis+and+in+a+Human+Colon+Cancer+Cell+Line.&rft.au=Janakiram%2C+Naveena+B%3BZhang%2C+Yuting%3BChoi%2C+Chang-In%3BMohammed%2C+Altaf%3BSteele%2C+Vernon+E%3BRao%2C+Chinthalapally+V&rft.aulast=Janakiram&rft.aufirst=Naveena&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Active Fraction of GSK3b in Cancer Cells by Non-Radioisotopic In Vitro Kinase Assay. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40862034; 4823488 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Mai, Wei AU - Shakoori, Abbas AU - Miyashita, Katsuyoshi AU - Zhang, Bin AU - Motoo, Yoshiharu AU - Kawakami, Kazuyuki AU - Takahashi, Yutaka AU - Minamoto, Toshinari Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40862034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Detection+of+Active+Fraction+of+GSK3b+in+Cancer+Cells+by+Non-Radioisotopic+In+Vitro+Kinase+Assay.&rft.au=Mai%2C+Wei%3BShakoori%2C+Abbas%3BMiyashita%2C+Katsuyoshi%3BZhang%2C+Bin%3BMotoo%2C+Yoshiharu%3BKawakami%2C+Kazuyuki%3BTakahashi%2C+Yutaka%3BMinamoto%2C+Toshinari&rft.aulast=Mai&rft.aufirst=Wei&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Human Endogenous Retrovirus (HERV) Derived Kidney Cancer Antigen CT-RCC1 Induces Proliferation of CD8+ Antigen-specific T-cells In Vitro that Kill Renal Cell Carcinoma (RCC) and is Up-regulated by Inhibiting Histone Deacetylase T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861990; 4820780 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Rao, Sheila AU - Abdul, Tawab AU - Kurlander, Roger AU - Harashima, Nanae AU - Lundqvist, Andreas AU - Hong, Julie AU - Malinzak, Elizabeth B AU - Smith, Aleah AU - Cherkasova, Elena AU - McCoy, Philip AU - Schrump, David AU - Childs, Richard W Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Kidneys KW - Retrovirus KW - CD8 antigen KW - Lymphocytes T KW - Histone deacetylase KW - Renal cell carcinoma KW - Tumors KW - Histones KW - Antigens KW - Human endogenous retrovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+Human+Endogenous+Retrovirus+%28HERV%29+Derived+Kidney+Cancer+Antigen+CT-RCC1+Induces+Proliferation+of+CD8%2B+Antigen-specific+T-cells+In+Vitro+that+Kill+Renal+Cell+Carcinoma+%28RCC%29+and+is+Up-regulated+by+Inhibiting+Histone+Deacetylase&rft.au=Rao%2C+Sheila%3BAbdul%2C+Tawab%3BKurlander%2C+Roger%3BHarashima%2C+Nanae%3BLundqvist%2C+Andreas%3BHong%2C+Julie%3BMalinzak%2C+Elizabeth+B%3BSmith%2C+Aleah%3BCherkasova%2C+Elena%3BMcCoy%2C+Philip%3BSchrump%2C+David%3BChilds%2C+Richard+W&rft.aulast=Rao&rft.aufirst=Sheila&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling Reveals Distinct Changes in Cardiovascular Genes in PC3 Prostate Carcinoma Cells and Normal Cells Treated with NSAIDs and COX-2 RNAi. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861969; 4823467 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Palayoor, Sanjeewani T AU - Aryankalayil, Molykutty J AU - Cerna, David AU - Coleman, C Norman Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate carcinoma KW - Gene expression KW - Cyclooxygenase-2 KW - Nonsteroidal antiinflammatory drugs KW - Tumors KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Gene+Expression+Profiling+Reveals+Distinct+Changes+in+Cardiovascular+Genes+in+PC3+Prostate+Carcinoma+Cells+and+Normal+Cells+Treated+with+NSAIDs+and+COX-2+RNAi.&rft.au=Palayoor%2C+Sanjeewani+T%3BAryankalayil%2C+Molykutty+J%3BCerna%2C+David%3BColeman%2C+C+Norman&rft.aulast=Palayoor&rft.aufirst=Sanjeewani&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - JS-K, a Nitric Oxide-releasing Prodrug, Inhibits Growth of Lung Adenocarcinoma Cells through Increase in Oxidative/Nitrosative Stress, DNA Damage and Activation of Apoptosis. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861905; 4822298 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Maciag, Anna E AU - Chakrapani, Harinath AU - Gupta, Meghana B AU - Shami, Paul J AU - Saavedra, Joseph E AU - Anderson, Lucy M AU - Keefer, Larry K Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung KW - Stress KW - Apoptosis KW - Adenocarcinoma KW - DNA damage KW - Prodrugs KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Cancer&rft.atitle=Adoptive+cell+transfer%3A+a+clinical+path+to+effective+cancer+immunotherapy&rft.au=Rosenberg%2C+Steven+A%3BRestifo%2C+Nicholas+P%3BYang%2C+James+C%3BMorgan%2C+Richard+A%3BDudley%2C+Mark+E&rft.aulast=Rosenberg&rft.aufirst=Steven&rft.date=2008-04-01&rft.volume=8&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc2355 L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correlation between Clinical Outcome and Growth Factor Expression as Determined by Immunohistochemical Staining in Osteogenic Sarcoma. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861878; 4823428 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Abdeen, Ayesha AU - Chou, Alexander AU - Healey, John H AU - Khanna, Chand AU - Gorlick, Richard Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Growth factors KW - Osteosarcoma KW - Growth KW - Staining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Correlation+between+Clinical+Outcome+and+Growth+Factor+Expression+as+Determined+by+Immunohistochemical+Staining+in+Osteogenic+Sarcoma.&rft.au=Abdeen%2C+Ayesha%3BChou%2C+Alexander%3BHealey%2C+John+H%3BKhanna%2C+Chand%3BGorlick%2C+Richard&rft.aulast=Abdeen&rft.aufirst=Ayesha&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topology of NGEP, a Prostate Specific Cell: Cell Junction Protein and a Potential Prostate Immunotherapeutic Target. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861732; 4823479 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Das, Sudipto AU - Hahn, YoonSoo AU - Bera, Tapan K AU - Nagata, Satoshi AU - Willingham, Mark C AU - Peehl, Donna M AU - Lee, Byungkook AU - Pastan, Ira Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate KW - Cell junctions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Topology+of+NGEP%2C+a+Prostate+Specific+Cell%3A+Cell+Junction+Protein+and+a+Potential+Prostate+Immunotherapeutic+Target.&rft.au=Das%2C+Sudipto%3BHahn%2C+YoonSoo%3BBera%2C+Tapan+K%3BNagata%2C+Satoshi%3BWillingham%2C+Mark+C%3BPeehl%2C+Donna+M%3BLee%2C+Byungkook%3BPastan%2C+Ira&rft.aulast=Das&rft.aufirst=Sudipto&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Immune Response Genotypes on Non-Hodgkin Lymhoma Risk is Modified by a History of Atopic Conditions. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40861187; 4823398 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Cozen, Wendy AU - Hartge, Patricia AU - Engels, Eric A AU - Cerhan, James R AU - Severson, Richard K AU - Davis, Scott AU - Colt, Joanne AU - Ward, Mary H AU - Linet, Martha S AU - Bernstein, Leslie AU - Rothman, Nathaniel AU - Wang, Sophia S Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Immune response KW - Historical account KW - Genotypes KW - Atopy KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+Effect+of+Immune+Response+Genotypes+on+Non-Hodgkin+Lymhoma+Risk+is+Modified+by+a+History+of+Atopic+Conditions.&rft.au=Cozen%2C+Wendy%3BHartge%2C+Patricia%3BEngels%2C+Eric+A%3BCerhan%2C+James+R%3BSeverson%2C+Richard+K%3BDavis%2C+Scott%3BColt%2C+Joanne%3BWard%2C+Mary+H%3BLinet%2C+Martha+S%3BBernstein%2C+Leslie%3BRothman%2C+Nathaniel%3BWang%2C+Sophia+S&rft.aulast=Cozen&rft.aufirst=Wendy&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous DNA Damage and Risk of Testicular Germ Cell Tumors T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40860915; 4821341 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Cook, Michael B AU - Sigurdson, Alice J AU - Thomas, Cynthia B AU - Graubard, Barry I AU - Korde, Larissa AU - Greene, Mark H AU - Jones, Irene M AU - McGlynn, Katherine A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Tumors KW - Germ cells KW - DNA damage KW - Testes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Endogenous+DNA+Damage+and+Risk+of+Testicular+Germ+Cell+Tumors&rft.au=Cook%2C+Michael+B%3BSigurdson%2C+Alice+J%3BThomas%2C+Cynthia+B%3BGraubard%2C+Barry+I%3BKorde%2C+Larissa%3BGreene%2C+Mark+H%3BJones%2C+Irene+M%3BMcGlynn%2C+Katherine+A&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Folate Pathway Polymorphisms are Related to Neuropsychological Impairment in Childhood Leukemia Survivors. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40860659; 4823427 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Kamdar, Kala Y AU - Potter, Brian S AU - Yan, Jingrong AU - Harris, Lynette L AU - Krull, Kevin R AU - Brouwers, Pim AU - Bondy, Melissa L AU - El-Zein, Randa A AU - Okcu, M Fatih Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Leukemia KW - Children KW - Folic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Folate+Pathway+Polymorphisms+are+Related+to+Neuropsychological+Impairment+in+Childhood+Leukemia+Survivors.&rft.au=Kamdar%2C+Kala+Y%3BPotter%2C+Brian+S%3BYan%2C+Jingrong%3BHarris%2C+Lynette+L%3BKrull%2C+Kevin+R%3BBrouwers%2C+Pim%3BBondy%2C+Melissa+L%3BEl-Zein%2C+Randa+A%3BOkcu%2C+M+Fatih&rft.aulast=Kamdar&rft.aufirst=Kala&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of JS-K, a Novel Anti-Cancer Nitric Oxide Prodrug, on Gene Expression in Human Myeloid Leukemia Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859971; 4822705 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Shami, Paul J AU - Malaviya, Swati AU - Tari, Ana AU - Saavedra, Joseph E AU - Keefer, Larry K AU - Tokar, Erik AU - Sun, Yang AU - Waalkes, Michael P AU - Liu, Jie Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Myeloid leukemia KW - Nitric oxide KW - Gene expression KW - Prodrugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Effect+of+JS-K%2C+a+Novel+Anti-Cancer+Nitric+Oxide+Prodrug%2C+on+Gene+Expression+in+Human+Myeloid+Leukemia+Cells.&rft.au=Shami%2C+Paul+J%3BMalaviya%2C+Swati%3BTari%2C+Ana%3BSaavedra%2C+Joseph+E%3BKeefer%2C+Larry+K%3BTokar%2C+Erik%3BSun%2C+Yang%3BWaalkes%2C+Michael+P%3BLiu%2C+Jie&rft.aulast=Shami&rft.aufirst=Paul&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis and Antineoplastic Activity of Bis-diazeniumdiolate Analogues of the Nitric Oxide-generating Prodrug JS-K T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859817; 4822335 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Keefer, Larry K AU - Andrei, Daniela AU - Maciag, Anna AU - Chakrapani, Harinath AU - Citro, Michael L AU - Saavedra, Joseph E AU - Shami, Paul J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prodrugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Synthesis+and+Antineoplastic+Activity+of+Bis-diazeniumdiolate+Analogues+of+the+Nitric+Oxide-generating+Prodrug+JS-K&rft.au=Keefer%2C+Larry+K%3BAndrei%2C+Daniela%3BMaciag%2C+Anna%3BChakrapani%2C+Harinath%3BCitro%2C+Michael+L%3BSaavedra%2C+Joseph+E%3BShami%2C+Paul+J&rft.aulast=Keefer&rft.aufirst=Larry&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - STAT3 N-Domain as a Drug Target: Rationally Designed Inhibitors Uncover Important Role in Protein Function. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859730; 4823979 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Timofeeva, Olga A AU - Gaponenko, Vadim AU - Lockett, Stephen J AU - Tarasov, Sergey G AU - Jiang, Sheng AU - Zhang, Xueping AU - Michejda, Christopher J AU - Perantoni, Alan O AU - Tarasova, Nadya Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Drugs KW - Stat3 protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=STAT3+N-Domain+as+a+Drug+Target%3A+Rationally+Designed+Inhibitors+Uncover+Important+Role+in+Protein+Function.&rft.au=Timofeeva%2C+Olga+A%3BGaponenko%2C+Vadim%3BLockett%2C+Stephen+J%3BTarasov%2C+Sergey+G%3BJiang%2C+Sheng%3BZhang%2C+Xueping%3BMichejda%2C+Christopher+J%3BPerantoni%2C+Alan+O%3BTarasova%2C+Nadya&rft.aulast=Timofeeva&rft.aufirst=Olga&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation in the Androgen Receptor Gene and Risk of Endometrial Cancer. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40859662; 4824063 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Yang, Hannah AU - Garcia-Closas, Montserrat AU - Lacey Jr, James V AU - Brinton, Louise A AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Chanock, Stephen AU - Gaudet, Mia M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cancer KW - Genetic diversity KW - Androgen receptors KW - Endometrium KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Genetic+Variation+in+the+Androgen+Receptor+Gene+and+Risk+of+Endometrial+Cancer.&rft.au=Yang%2C+Hannah%3BGarcia-Closas%2C+Montserrat%3BLacey+Jr%2C+James+V%3BBrinton%2C+Louise+A%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BChanock%2C+Stephen%3BGaudet%2C+Mia+M&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor-stroma Interactions in Ovarian Cancer: The Role of CTGF in Ovarian Tumor Biology T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40857818; 4822536 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Samimi, Goli AU - Bonome, Tomas AU - Ghosh, Sue AU - Ng, Shu-wing AU - Mok, Samuel C AU - Birrer, Michael J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Ovarian cancer KW - Tumors KW - Connective tissue growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tumor-stroma+Interactions+in+Ovarian+Cancer%3A+The+Role+of+CTGF+in+Ovarian+Tumor+Biology&rft.au=Samimi%2C+Goli%3BBonome%2C+Tomas%3BGhosh%2C+Sue%3BNg%2C+Shu-wing%3BMok%2C+Samuel+C%3BBirrer%2C+Michael+J&rft.aulast=Samimi&rft.aufirst=Goli&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cisplatin Markedly Enhances Microtubule Depolymerization in A549 Cell Line Compared with Oxaliplatin. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856387; 4822648 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Min, Young Joo AU - Poruchynsky, Marianne S AU - Sackett, Dan L AU - Murphy, Bob AU - Fojo, Tito Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cisplatin KW - Oxaliplatin KW - Depolymerization KW - Microtubules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cisplatin+Markedly+Enhances+Microtubule+Depolymerization+in+A549+Cell+Line+Compared+with+Oxaliplatin.&rft.au=Min%2C+Young+Joo%3BPoruchynsky%2C+Marianne+S%3BSackett%2C+Dan+L%3BMurphy%2C+Bob%3BFojo%2C+Tito&rft.aulast=Min&rft.aufirst=Young&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transepithelial Drug Transport by Human ABCB1 and its Haplotype Expressed in Recombinant LLC-PK1 Cells. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856254; 4822724 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Fung, King Leung AU - Gottesman, Michael M Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Haplotypes KW - Drugs KW - Recombinants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Transepithelial+Drug+Transport+by+Human+ABCB1+and+its+Haplotype+Expressed+in+Recombinant+LLC-PK1+Cells.&rft.au=Fung%2C+King+Leung%3BGottesman%2C+Michael+M&rft.aulast=Fung&rft.aufirst=King&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Dose Toxicity of 6-Aminonicotinamide (6-AN, NSC-21206), Methylmercaptopurineriboside (6-MMPR, NSC-40774), and L-Aspartic Acid-N-Phosphonoacetyl Disodiumsalt (PALA, NSC-224131) in Beagle Dogs. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40856129; 4823892 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Tosca, Patricia J AU - Merrill, John W AU - Vasconcelos, Daphne AU - Ryan, Michael J AU - Johnson, Jerry D AU - Rizvi, Naiyer AU - Schweikart, Karen AU - Tomaszewski, Joseph E Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - India, Uttar Pradesh, Palas KW - Toxicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40856129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Single+Dose+Toxicity+of+6-Aminonicotinamide+%286-AN%2C+NSC-21206%29%2C+Methylmercaptopurineriboside+%286-MMPR%2C+NSC-40774%29%2C+and+L-Aspartic+Acid-N-Phosphonoacetyl+Disodiumsalt+%28PALA%2C+NSC-224131%29+in+Beagle+Dogs.&rft.au=Tosca%2C+Patricia+J%3BMerrill%2C+John+W%3BVasconcelos%2C+Daphne%3BRyan%2C+Michael+J%3BJohnson%2C+Jerry+D%3BRizvi%2C+Naiyer%3BSchweikart%2C+Karen%3BTomaszewski%2C+Joseph+E&rft.aulast=Tosca&rft.aufirst=Patricia&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intrinsic Resistance to TRAIL Therapy is Abrogated by Targeted Knockdown of XIAP Using siRNA in Human Lung Cancer Cells T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855819; 4820242 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Yang, Jianhui AU - Loehfelm, Amy E AU - Cooper, Lindsay B AU - Kwong, King F Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - TRAIL protein KW - SiRNA KW - XIAP protein KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Intrinsic+Resistance+to+TRAIL+Therapy+is+Abrogated+by+Targeted+Knockdown+of+XIAP+Using+siRNA+in+Human+Lung+Cancer+Cells&rft.au=Yang%2C+Jianhui%3BLoehfelm%2C+Amy+E%3BCooper%2C+Lindsay+B%3BKwong%2C+King+F&rft.aulast=Yang&rft.aufirst=Jianhui&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokeratin-RNA Crosslinking Mediated by the Antitumor Aminoflavone, NSC 686288. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855534; 4822694 DE: JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Meng, Lingua AU - Meng, Zhaojing AU - Miao, Ze-hong AU - Veenstra, Timothy D AU - Pommier, Yves Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Cytokeratin-RNA+Crosslinking+Mediated+by+the+Antitumor+Aminoflavone%2C+NSC+686288.&rft.au=Meng%2C+Lingua%3BMeng%2C+Zhaojing%3BMiao%2C+Ze-hong%3BVeenstra%2C+Timothy+D%3BPommier%2C+Yves&rft.aulast=Meng&rft.aufirst=Lingua&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intake of Quercetin and Isothiocyanates and Risk of Lung Cancer: A Population-Based Case-Control Study. T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40855336; 4822600 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Lam, Tram K AU - Rotunno, Melissa AU - Randi, Giorgia AU - Bagnardi, Vincenzo AU - Subar, Amy F AU - Landi, Maria Teresa Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Quercetin KW - Isothiocyanate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Intake+of+Quercetin+and+Isothiocyanates+and+Risk+of+Lung+Cancer%3A+A+Population-Based+Case-Control+Study.&rft.au=Lam%2C+Tram+K%3BRotunno%2C+Melissa%3BRandi%2C+Giorgia%3BBagnardi%2C+Vincenzo%3BSubar%2C+Amy+F%3BLandi%2C+Maria+Teresa&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Functionality of CD4+CD25highFoxp3+ Regulatory T Cells in the Peripheral Blood of Prostate Cancer Patients T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854828; 4819927 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Cereda, Vittore AU - Yokokawa, Junko AU - Remondo, Cinzia AU - Gulley, James L AU - Arlen, Philip M AU - Schlom, Jeffrey AU - Tsang, Kwong Y Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Lymphocytes T KW - Immunoregulation KW - Peripheral blood KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Enhanced+Functionality+of+CD4%2BCD25highFoxp3%2B+Regulatory+T+Cells+in+the+Peripheral+Blood+of+Prostate+Cancer+Patients&rft.au=Cereda%2C+Vittore%3BYokokawa%2C+Junko%3BRemondo%2C+Cinzia%3BGulley%2C+James+L%3BArlen%2C+Philip+M%3BSchlom%2C+Jeffrey%3BTsang%2C+Kwong+Y&rft.aulast=Cereda&rft.aufirst=Vittore&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tuberculosis and Lung Cancer in Xuanwei, China T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40854781; 4819774 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Engels, Eric A AU - Shen, Min AU - Chapman, Robert S AU - Yu, Ying-Ying AU - He, Xingzhou AU - Lan, Qing Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - China, People's Rep. KW - Tuberculosis KW - Lung cancer KW - Mycobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Tuberculosis+and+Lung+Cancer+in+Xuanwei%2C+China&rft.au=Engels%2C+Eric+A%3BShen%2C+Min%3BChapman%2C+Robert+S%3BYu%2C+Ying-Ying%3BHe%2C+Xingzhou%3BLan%2C+Qing&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Effects of Caliban/Sdccag1 on Growth of Human Lung Cancer Cells in a Mouse Model of Lung Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853983; 4820319 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Mortin, Mark A AU - Bi, Xiaolin AU - Kennison, James AU - Hursh, Deborah A AU - Bhattacharya, Bhaskar AU - Joshi, Bharat H AU - Puri, Raj Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Animal models KW - Growth rate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=In+Vivo+Effects+of+Caliban%2FSdccag1+on+Growth+of+Human+Lung+Cancer+Cells+in+a+Mouse+Model+of+Lung+Cancer&rft.au=Mortin%2C+Mark+A%3BBi%2C+Xiaolin%3BKennison%2C+James%3BHursh%2C+Deborah+A%3BBhattacharya%2C+Bhaskar%3BJoshi%2C+Bharat+H%3BPuri%2C+Raj&rft.aulast=Mortin&rft.aufirst=Mark&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carcinogenic Potential of Tar-based Vaginal Douche Products and Cervical Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853748; 4822115 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Haverkos, Harry W AU - Boring, Daniel AU - Kruhlak, Naomi L AU - Matthews, Edwin J Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Cervical cancer KW - Carcinogenicity KW - Vagina KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Carcinogenic+Potential+of+Tar-based+Vaginal+Douche+Products+and+Cervical+Cancer&rft.au=Haverkos%2C+Harry+W%3BBoring%2C+Daniel%3BKruhlak%2C+Naomi+L%3BMatthews%2C+Edwin+J&rft.aulast=Haverkos&rft.aufirst=Harry&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The XRCC1 R399Q Polymorphism is Associated with Response to Radiotherapy in Prostate Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40853431; 4820460 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - GAO, Rui AU - Price, Douglas K AU - Figg, William D Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Prostate cancer KW - Radiotherapy KW - XRCC1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40853431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=The+XRCC1+R399Q+Polymorphism+is+Associated+with+Response+to+Radiotherapy+in+Prostate+Cancer&rft.au=GAO%2C+Rui%3BPrice%2C+Douglas+K%3BFigg%2C+William+D&rft.aulast=GAO&rft.aufirst=Rui&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Expression of Antioxidant Response Element Target Genes in Bronchial Epithelial Cells of Smokers with Lung Cancer T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852803; 4820340 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Wang, Xuting AU - Shah, Vishal AU - Pittman, Gary S AU - Chorley, Brian N AU - Liu, Gang AU - Brody, Jerome S AU - Kleeberger, Steven R AU - Spira, Avrum AU - Bell, Douglas A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Lung cancer KW - Antioxidants KW - Regulatory sequences KW - Epithelial cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Altered+Expression+of+Antioxidant+Response+Element+Target+Genes+in+Bronchial+Epithelial+Cells+of+Smokers+with+Lung+Cancer&rft.au=Wang%2C+Xuting%3BShah%2C+Vishal%3BPittman%2C+Gary+S%3BChorley%2C+Brian+N%3BLiu%2C+Gang%3BBrody%2C+Jerome+S%3BKleeberger%2C+Steven+R%3BSpira%2C+Avrum%3BBell%2C+Douglas+A&rft.aulast=Wang&rft.aufirst=Xuting&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting HER1 and HER2 Using @@u86@Y-CHX-A" Labeled Cetuximab and Trastuzumab for PET Imaging T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40852437; 4821982 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Regino, Celeste A.S. AU - Milenic, Diane E AU - Wong, Karen J AU - Garmestani, Kayhan AU - Baidoo, Kwamena AU - Williams, Mark AU - Seidel, Jurgen AU - Green, Michael AU - Choyke, Peter L AU - Brechbiel, Martin W Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - ErbB-2 protein KW - Trastuzumab KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40852437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Targeting+HER1+and+HER2+Using+%40%40u86%40Y-CHX-A%22+Labeled+Cetuximab+and+Trastuzumab+for+PET+Imaging&rft.au=Regino%2C+Celeste+A.S.%3BMilenic%2C+Diane+E%3BWong%2C+Karen+J%3BGarmestani%2C+Kayhan%3BBaidoo%2C+Kwamena%3BWilliams%2C+Mark%3BSeidel%2C+Jurgen%3BGreen%2C+Michael%3BChoyke%2C+Peter+L%3BBrechbiel%2C+Martin+W&rft.aulast=Regino&rft.aufirst=Celeste&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measuring p53 Binding to Promoter Regulatory Elements with Fluorescent Microspheres T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40851245; 4821914 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Noureddine, Maher AU - Menendez, Daniel AU - Campbell, Michelle AU - Wang, Xuting AU - Pittman, Gary S AU - Horvath, Monica M AU - Resnick, Michael A AU - Bell, Douglas A Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Microspheres KW - Regulatory sequences KW - Promoters KW - P53 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40851245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Measuring+p53+Binding+to+Promoter+Regulatory+Elements+with+Fluorescent+Microspheres&rft.au=Noureddine%2C+Maher%3BMenendez%2C+Daniel%3BCampbell%2C+Michelle%3BWang%2C+Xuting%3BPittman%2C+Gary+S%3BHorvath%2C+Monica+M%3BResnick%2C+Michael+A%3BBell%2C+Douglas+A&rft.aulast=Noureddine&rft.aufirst=Maher&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morphological Response of Tumor Histology in a Phase I Trial of Sorafenib and Bevacizumab T2 - 2008 Annual Meeting of the American Association for Cancer Research AN - 40846927; 4819714 JF - 2008 Annual Meeting of the American Association for Cancer Research AU - Henning, Ryan K AU - Kohn, Elise AU - Yu, Minshu AU - Azad, Nilofer Y1 - 2008/04/12/ PY - 2008 DA - 2008 Apr 12 KW - Histology KW - Tumors KW - Bevacizumab KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40846927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Morphological+Response+of+Tumor+Histology+in+a+Phase+I+Trial+of+Sorafenib+and+Bevacizumab&rft.au=Henning%2C+Ryan+K%3BKohn%2C+Elise%3BYu%2C+Minshu%3BAzad%2C+Nilofer&rft.aulast=Henning&rft.aufirst=Ryan&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9EE8A282%2D2B9E%2D4B30% 2D997A%2DE97A0A4C2FEC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Five-Factor Model personality profiles of drug users. AN - 69184868; 18405382 AB - Personality traits are considered risk factors for drug use, and, in turn, the psychoactive substances impact individuals' traits. Furthermore, there is increasing interest in developing treatment approaches that match an individual's personality profile. To advance our knowledge of the role of individual differences in drug use, the present study compares the personality profile of tobacco, marijuana, cocaine, and heroin users and non-users using the wide spectrum Five-Factor Model (FFM) of personality in a diverse community sample. Participants (N = 1,102; mean age = 57) were part of the Epidemiologic Catchment Area (ECA) program in Baltimore, MD, USA. The sample was drawn from a community with a wide range of socio-economic conditions. Personality traits were assessed with the Revised NEO Personality Inventory (NEO-PI-R), and psychoactive substance use was assessed with systematic interview. Compared to never smokers, current cigarette smokers score lower on Conscientiousness and higher on Neuroticism. Similar, but more extreme, is the profile of cocaine/heroin users, which score very high on Neuroticism, especially Vulnerability, and very low on Conscientiousness, particularly Competence, Achievement-Striving, and Deliberation. By contrast, marijuana users score high on Openness to Experience, average on Neuroticism, but low on Agreeableness and Conscientiousness. In addition to confirming high levels of negative affect and impulsive traits, this study highlights the links between drug use and low Conscientiousness. These links provide insight into the etiology of drug use and have implications for public health interventions. JF - BMC psychiatry AU - Terracciano, Antonio AU - Löckenhoff, Corinna E AU - Crum, Rosa M AU - Bienvenu, O Joseph AU - Costa, Paul T AD - National Institute on Aging, NIH, DHHS, Baltimore, USA. TerraccianoA@grc.nia.nih.gov Y1 - 2008/04/11/ PY - 2008 DA - 2008 Apr 11 SP - 22 VL - 8 KW - Index Medicus KW - Humans KW - Cocaine-Related Disorders -- epidemiology KW - Smoking -- psychology KW - Baltimore -- epidemiology KW - Smoking -- epidemiology KW - Cross-Sectional Studies KW - Cocaine-Related Disorders -- genetics KW - Heroin Dependence -- epidemiology KW - Marijuana Abuse -- epidemiology KW - Marijuana Abuse -- psychology KW - Middle Aged KW - Sample Size KW - Heroin Dependence -- psychology KW - Prevalence KW - Models, Psychological KW - Personality KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69184868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+psychiatry&rft.atitle=Five-Factor+Model+personality+profiles+of+drug+users.&rft.au=Terracciano%2C+Antonio%3BL%C3%B6ckenhoff%2C+Corinna+E%3BCrum%2C+Rosa+M%3BBienvenu%2C+O+Joseph%3BCosta%2C+Paul+T&rft.aulast=Terracciano&rft.aufirst=Antonio&rft.date=2008-04-11&rft.volume=8&rft.issue=&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=BMC+psychiatry&rft.issn=1471-244X&rft_id=info:doi/10.1186%2F1471-244X-8-22 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-06 N1 - Date created - 2008-05-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Nov 22-29;284(20):2606-10 [11086367] BMC Psychiatry. 2007;7:29 [17594479] Addiction. 2001 Nov;96(11):1615-28 [11784458] Addict Behav. 2002 Mar-Apr;27(2):193-206 [11817762] Neuroreport. 2002 Jul 2;13(9):1097-106 [12151749] Encephale. 2003 Jul-Aug;29(4 Pt 1):285-92 [14615698] Addict Behav. 2004 Jan;29(1):17-32 [14667418] Educ Health (Abingdon). 2003 Jul;16(2):230 [14741909] Psychol Med. 2004 Feb;34(2):323-33 [14982138] Addiction. 2004 Apr;99(4):472-81 [15049747] J Psychiatr Res. 1975 Nov;12(3):189-98 [1202204] Br J Addict. 1985 Sep;80(3):315-9 [3864483] JAMA. 1990 Nov 21;264(19):2511-8 [2232018] J Pers Assess. 1991 Dec;57(3):415-33 [1757869] Drug Alcohol Depend. 1992 Feb;29(3):283-90 [1559435] J Subst Abuse. 1990;2(2):255-63 [2136114] J Pers. 1992 Jun;60(2):175-215 [1635039] Behav Genet. 1995 Mar;25(2):133-47 [7733855] Subst Use Misuse. 1997 Jan;32(1):25-41 [9044535] Addiction. 1997 Apr;92(4):469-72 [9177068] Addiction. 1997 Aug;92(8):1023-33 [9376772] Arch Gen Psychiatry. 1997 Nov;54(11):993-9 [9366655] Arch Gen Psychiatry. 1998 Feb;55(2):161-6 [9477930] BMC Psychiatry. 2007;7:37 [17683593] Psychosom Med. 2008 Jul;70(6):621-7 [18596250] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] Addiction. 1998 Jan;93(1):27-39 [9624709] Am J Prev Med. 1998 May;14(4):245-58 [9635069] Psychol Bull. 2004 Nov;130(6):887-919 [15535742] Psychol Med. 2004 Oct;34(7):1251-61 [15697051] J Pers Soc Psychol. 2005 Mar;88(3):547-61 [15740445] Am J Public Health. 2005 Jun;95(6):1016-23 [15914827] Arch Gen Psychiatry. 2005 Jun;62(6):617-27 [15939839] Int J Psychiatry Med. 2005;35(1):59-74 [15977945] Psychol Aging. 2005 Sep;20(3):493-506 [16248708] Addict Behav. 2006 Feb;31(2):232-45 [15953689] Health Psychol. 2006 Jan;25(1):57-64 [16448298] J Gerontol B Psychol Sci Soc Sci. 2006 Mar;61(2):P108-16 [16497954] Addiction. 2006 Mar;101(3):315-22 [16499503] Pers Soc Psychol Bull. 2006 Aug;32(8):999-1009 [16861305] Addiction. 2006 Oct;101(10):1384-93 [16968336] J Drug Educ. 2006;36(1):47-58 [16981639] Psychopharmacology (Berl). 2006 Nov;189(1):125-33 [16977477] PLoS Genet. 2006 Aug 25;2(8):e132 [16934002] Epidemiol Psichiatr Soc. 2006 Jul-Sep;15(3):176-84 [17128620] Addiction. 2006 Dec;101(12):1814-21 [17156181] Drug Alcohol Rev. 2007 Jan;26(1):17-23 [17364832] Nicotine Tob Res. 2007 Mar;9(3):397-404 [17365771] Lancet. 2007 Mar 24;369(9566):1047-53 [17382831] Drug Alcohol Depend. 2007 May;88 Suppl 2:S14-23 [17257782] J Pers Soc Psychol. 2001 Sep;81(3):524-39 [11554651] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-244X-8-22 ER - TY - JOUR T1 - Smad3 deficiency inhibits v-ras-induced transformation by suppression of JNK MAPK signaling and increased farnesyl transferase inhibition. AN - 70478368; 17952112 AB - The ability of transforming growth factor-beta (TGF-beta) to modulate various effects on distinct cell lineages has been a central feature of its multi-faceted nature. The purpose of this study was to access the effects of deletion of a key TGF-beta signal transducer, Smad3, on MAPK activation and v-Ras(Ha)-transformation of primary mouse embryonic fibroblasts (MEFs). We observe reduced TGF-beta1 and v-ras(Ha) mediated activation of the JNK and ERK MAPK pathway upon ablation of Smad3. Further, Smad3-deficient MEFs demonstrate resistance to v-ras(Ha)-induced transformation while the absence of Smad3 results in increased inhibition of farnesyl transferase activity. Taken together, these observations demonstrate that the absence of Smad3 protects fibroblasts from oncogenic transformation by (i) augmenting farnesyl transferase inhibition and (ii) suppressing the Ras-JNK MAPK pathway. These results provide new insights into the molecular mechanisms involved in v-Ras(Ha) oncogene-induced mesenchymal phenotypic transformation. JF - Oncogene AU - Arany, P R AU - Rane, S G AU - Roberts, A B AD - Laboratory of Cell Regulation and Carcinogenesis, NCI, NIH, Bethesda, MD, USA. arany@fas.harvard.edu Y1 - 2008/04/10/ PY - 2008 DA - 2008 Apr 10 SP - 2507 EP - 2512 VL - 27 IS - 17 KW - Smad3 Protein KW - 0 KW - Transforming Growth Factor beta KW - Alkyl and Aryl Transferases KW - EC 2.5.- KW - p21(ras) farnesyl-protein transferase KW - EC 2.5.1.- KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase Kinases KW - EC 2.7.12.2 KW - Oncogene Protein p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Phenotype KW - Transforming Growth Factor beta -- pharmacology KW - Animals KW - Cells, Cultured KW - Cercopithecus aethiops KW - Enzyme Activation -- drug effects KW - Mice KW - Gene Expression Regulation KW - Cell Line, Transformed KW - Cell Transformation, Neoplastic KW - MAP Kinase Signaling System -- drug effects KW - Oncogene Protein p21(ras) -- genetics KW - Mitogen-Activated Protein Kinases -- metabolism KW - Oncogene Protein p21(ras) -- metabolism KW - Smad3 Protein -- metabolism KW - Smad3 Protein -- deficiency KW - Transgenes -- genetics KW - Mitogen-Activated Protein Kinase Kinases -- metabolism KW - Smad3 Protein -- genetics KW - Alkyl and Aryl Transferases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70478368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Smad3+deficiency+inhibits+v-ras-induced+transformation+by+suppression+of+JNK+MAPK+signaling+and+increased+farnesyl+transferase+inhibition.&rft.au=Arany%2C+P+R%3BRane%2C+S+G%3BRoberts%2C+A+B&rft.aulast=Arany&rft.aufirst=P&rft.date=2008-04-10&rft.volume=27&rft.issue=17&rft.spage=2507&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-01 N1 - Date created - 2008-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impaired T sub(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome AN - 20845722; 8126033 AB - The autosomal dominant hyper-IgE syndrome (HIES, 'Job's syndrome') is characterized by recurrent and often severe pulmonary infections, pneumatoceles, eczema, staphylococcal abscesses, mucocutaneous candidiasis, and abnormalities of bone and connective tissue. Mutations presumed to underlie HIES have recently been identified in stat3, the gene encoding STAT3 (signal transducer and activator of transcription 3). Although impaired production of interferon-gamma and tumour-necrosis factor by T cells, diminished memory T-cell populations, decreased delayed-type-hypersensitivity responses and decreased in vitro lymphoproliferation in response to specific antigens have variably been described, specific immunological abnormalities that can explain the unique susceptibility to particular infections seen in HIES have not yet been defined. Here we show that interleukin (IL)-17 production by T cells is absent in HIES individuals. We observed that ex vivo T cells from subjects with HIES failed to produce IL-17, but not IL-2, tumour-necrosis factor or interferon-gamma, on mitogenic stimulation with staphylococcal enterotoxin B or on antigenic stimulation with Candida albicans or streptokinase. Purified naive T cells were unable to differentiate into IL-17-producing (T sub(H)17) T helper cells in vitro and had lower expression of retinoid-related orphan receptor (ROR)- gammat, which is consistent with a crucial role for STAT3 signalling in the generation of T sub(H)17 cells. T sub(H)17 cells have emerged as an important subset of helper T cells that are believed to be critical in the clearance of fungal and extracellular bacterial infections. Thus, our data suggest that the inability to produce T sub(H)17 cells is a mechanism underlying the susceptibility to the recurrent infections commonly seen in HIES. JF - Nature AU - Milner, Joshua D AU - Brenchley, Jason M AU - Laurence, Arian AU - Freeman, Alexandra F AU - Hill, Brenna J AU - Elias, Kevin M AU - Kanno, Yuka AU - Spalding, Christine AU - Elloumi, Houda Z AU - Paulson, Michelle L AU - Davis, Joie AU - Hsu, Amy AU - Asher, Ava I AU - O'Shea, John AU - Holland, Steven M AU - Paul, William E AU - Douek, Daniel C AD - Laboratory of Immunology, Human Immunology Section, Vaccine Research Center, and, Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2008/04/10/ PY - 2008 DA - 2008 Apr 10 SP - 773 EP - 776 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 452 IS - 7188 SN - 0028-0836, 0028-0836 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - gamma -Interferon KW - Candidiasis KW - Interleukin 2 KW - Connective tissues KW - Orphan receptors KW - Helper cells KW - Immunological memory KW - Eczema KW - Differentiation KW - Interleukin 17 KW - Lymphocytes T KW - Recurrent infection KW - Job's syndrome KW - Data processing KW - Stat3 protein KW - Memory cells KW - Transcription KW - Candida albicans KW - Abscesses KW - Staphylococcal enterotoxin B KW - Bone KW - Lung KW - streptokinase KW - Mutation KW - Signal transduction KW - K 03350:Immunology KW - N 14830:RNA KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20845722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Impaired+T+sub%28H%2917+cell+differentiation+in+subjects+with+autosomal+dominant+hyper-IgE+syndrome&rft.au=Milner%2C+Joshua+D%3BBrenchley%2C+Jason+M%3BLaurence%2C+Arian%3BFreeman%2C+Alexandra+F%3BHill%2C+Brenna+J%3BElias%2C+Kevin+M%3BKanno%2C+Yuka%3BSpalding%2C+Christine%3BElloumi%2C+Houda+Z%3BPaulson%2C+Michelle+L%3BDavis%2C+Joie%3BHsu%2C+Amy%3BAsher%2C+Ava+I%3BO%27Shea%2C+John%3BHolland%2C+Steven+M%3BPaul%2C+William+E%3BDouek%2C+Daniel+C&rft.aulast=Milner&rft.aufirst=Joshua&rft.date=2008-04-10&rft.volume=452&rft.issue=7188&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature06764 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Data processing; Interleukin 2; Candidiasis; Stat3 protein; Orphan receptors; Connective tissues; Helper cells; Immunological memory; Memory cells; Transcription; Eczema; Staphylococcal enterotoxin B; Abscesses; Bone; Differentiation; Lung; streptokinase; Interleukin 17; Lymphocytes T; Recurrent infection; Mutation; Job's syndrome; Signal transduction; Candida albicans DO - http://dx.doi.org/10.1038/nature06764 ER - TY - JOUR T1 - Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. AN - 70497384; 18337749 AB - Human RNase H1 contains an N-terminal domain known as dsRHbd for binding both dsRNA and RNA/DNA hybrid. We find that dsRHbd binds preferentially to RNA/DNA hybrids by over 25-fold and rename it as hybrid binding domain (HBD). The crystal structure of HBD complexed with a 12 bp RNA/DNA hybrid reveals that the RNA strand is recognized by a protein loop, which forms hydrogen bonds with the 2'-OH groups. The DNA interface is highly specific and contains polar residues that interact with the phosphate groups and an aromatic patch that appears selective for binding deoxyriboses. HBD is unique relative to non-sequence-specific dsDNA- and dsRNA-binding domains because it does not use positive dipoles of alpha-helices for nucleic acid binding. Characterization of full-length enzymes with defective HBDs indicates that this domain dramatically enhances both the specific activity and processivity of RNase H1. Similar activity enhancement by small substrate-binding domains linked to the catalytic domain likely occurs in other nucleic acid enzymes. JF - The EMBO journal AU - Nowotny, Marcin AU - Cerritelli, Susana M AU - Ghirlando, Rodolfo AU - Gaidamakov, Sergei A AU - Crouch, Robert J AU - Yang, Wei AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 SP - 1172 EP - 1181 VL - 27 IS - 7 KW - Nucleic Acid Heteroduplexes KW - 0 KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - Ribonuclease H KW - EC 3.1.26.4 KW - ribonuclease HI KW - Index Medicus KW - Base Pairing KW - Animals KW - Protein Structure, Secondary KW - Humans KW - Molecular Sequence Data KW - Mice KW - Crystallography, X-Ray KW - Amino Acid Sequence KW - Substrate Specificity KW - Protein Structure, Tertiary KW - Protein Binding KW - Models, Biological KW - Mutagenesis KW - Ribonuclease H -- chemistry KW - Nucleic Acid Heteroduplexes -- metabolism KW - RNA -- metabolism KW - DNA -- metabolism KW - Ribonuclease H -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70497384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Trace+amounts+of+8-oxo-dGTP+in+mitochondrial+dNTP+pools+reduce+DNA+polymerase+gamma+replication+fidelity.&rft.au=Pursell%2C+Zachary+F%3BMcDonald%2C+J+Tyson%3BMathews%2C+Christopher+K%3BKunkel%2C+Thomas+A&rft.aulast=Pursell&rft.aufirst=Zachary&rft.date=2008-04-01&rft.volume=36&rft.issue=7&rft.spage=2174&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkn062 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-24 N1 - Date created - 2008-04-09 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 3BSU; PDB N1 - SuppNotes - Cited By: Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Nucleic Acids Res. 1998 Apr 1;26(7):1834-40 [9512560] EMBO J. 1998 Dec 15;17(24):7505-13 [9857205] Biochemistry. 1999 Jan 12;38(2):605-18 [9888800] J Mol Biol. 1999 Aug 20;291(3):661-9 [10448044] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Nucleic Acids Res. 2005;33(7):2166-75 [15831789] Cell. 2005 Jul 1;121(7):1005-16 [15989951] Nat Struct Mol Biol. 2005 Oct;12(10):935-6 [16155580] Cell. 2006 Jan 27;124(2):355-66 [16439209] EMBO J. 2006 May 3;25(9):1924-33 [16601679] Curr Opin Struct Biol. 2007 Feb;17(1):138-45 [17194582] Nat Rev Mol Cell Biol. 2007 Jun;8(6):479-90 [17473849] Mol Cell. 2007 Oct 26;28(2):264-76 [17964265] EMBO J. 2000 Mar 1;19(5):997-1009 [10698941] Nucleic Acids Res. 2000 Jul 15;28(14):2643-50 [10908318] Mol Cell. 2003 Mar;11(3):807-15 [12667461] J Virol. 2003 Aug;77(15):8577-83 [12857928] Nature. 1971 Jun 25;231(5304):506-11 [4932997] Adv Biophys. 1985;19:133-65 [2424281] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Science. 1991 May 10;252(5007):809-17 [2028256] Proteins. 1991;11(4):281-96 [1758883] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10979-83 [1438302] Nucleic Acids Res. 1994 Oct 11;22(20):4163-6 [7937142] Nucleic Acids Res. 1995 Mar 11;23(5):725-8 [7535921] EMBO J. 1995 Jul 17;14(14):3563-71 [7628456] RNA. 1995 May;1(3):246-59 [7489497] Nucleic Acids Res. 1996 Jul 1;24(13):2488-97 [8692686] Genomics. 1998 Nov 1;53(3):300-7 [9799596] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/emboj.2008.44 ER - TY - JOUR T1 - Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. AN - 70486499; 18355967 AB - We have expressed A-FOS, an inhibitor of activator protein-1 (AP-1) DNA binding, in adult mouse striatal neurons. We observed normal behavior including locomotion and exploratory activities. Following a single injection of cocaine, locomotion increased similarly in both the A-FOS expressing and littermate controls. However, following repeated injections of cocaine, the A-FOS expressing mice showed increased locomotion relative to littermate controls, an increase that persisted following a week of withdrawal and subsequent cocaine administration. These results indicate that AP-1 suppresses this behavioral response to cocaine. We analyzed mRNA from the striatum before and 4 and 24 h after a single cocaine injection in both A-FOS and control striata using Affymetrix microarrays (430 2.0 Array) to identify genes mis-regulated by A-FOS that may mediate the increased locomotor sensitization to cocaine. A-FOS expression did not change gene expression in the basal state or 4 h following cocaine treatment relative to controls. However, 24 h after an acute cocaine treatment, 84 genes were identified that were differentially expressed between the A-FOS and control mice. Fifty-six genes are down-regulated while 28 genes are up-regulated including previously identified candidates for addiction including brain-derived neurotrophic factor and period homolog 1. Using a random sample of identified genes, quantitative PCR was used to verify the microarray studies. The chromosomal location of these 84 genes was compared with human genome scans of addiction to identify potential genes in humans that are involved in addiction. JF - Neuroscience AU - Paletzki, R F AU - Myakishev, M V AU - Polesskaya, O AU - Orosz, A AU - Hyman, S E AU - Vinson, C AD - Laboratory of Molecular Pathophysiology, National Institute of Neurological Disorders and Stroke, NIH, Building 36, Room 4C-24, Bethesda, MD 20892, USA. Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 SP - 1040 EP - 1053 VL - 152 IS - 4 SN - 0306-4522, 0306-4522 KW - Dopamine Uptake Inhibitors KW - 0 KW - RNA, Messenger KW - Replication Protein C KW - Phosphopyruvate Hydratase KW - EC 4.2.1.11 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Age Factors KW - Dose-Response Relationship, Drug KW - Mice KW - Phosphopyruvate Hydratase -- genetics KW - Locomotion -- drug effects KW - Chromosome Mapping -- methods KW - Mice, Transgenic KW - Animals, Newborn KW - Behavior, Animal -- drug effects KW - Phosphopyruvate Hydratase -- metabolism KW - RNA, Messenger -- metabolism KW - Exploratory Behavior -- drug effects KW - Corpus Striatum -- drug effects KW - Microarray Analysis -- methods KW - Time Factors KW - Cocaine-Related Disorders -- genetics KW - Replication Protein C -- metabolism KW - Cocaine-Related Disorders -- physiopathology KW - Gene Expression Regulation -- drug effects KW - Replication Protein C -- genetics KW - Cocaine -- pharmacology KW - Gene Expression Regulation -- genetics KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70486499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Inhibiting+activator+protein-1+activity+alters+cocaine-induced+gene+expression+and+potentiates+sensitization.&rft.au=Paletzki%2C+R+F%3BMyakishev%2C+M+V%3BPolesskaya%2C+O%3BOrosz%2C+A%3BHyman%2C+S+E%3BVinson%2C+C&rft.aulast=Paletzki&rft.aufirst=R&rft.date=2008-04-09&rft.volume=152&rft.issue=4&rft.spage=1040&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2008.01.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-07 N1 - Date created - 2008-04-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2008.01.045 ER - TY - CPAPER T1 - US National Institutes of Health Update T2 - Third International Conference on TB Vaccines for the World (TBV 2008) AN - 40959518; 4869174 JF - Third International Conference on TB Vaccines for the World (TBV 2008) AU - Lacourciere, Karen A Y1 - 2008/04/09/ PY - 2008 DA - 2008 Apr 09 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40959518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.atitle=US+National+Institutes+of+Health+Update&rft.au=Lacourciere%2C+Karen+A&rft.aulast=Lacourciere&rft.aufirst=Karen&rft.date=2008-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Third+International+Conference+on+TB+Vaccines+for+the+World+%28TBV+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/tbv_2008/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Evolutionary Dynamics of Influenza A Viruses T2 - 2008 Keystone Symposia on Molecular Evolution as a Driving Force in Infectious Diseases (D4) AN - 40824698; 4802727 JF - 2008 Keystone Symposia on Molecular Evolution as a Driving Force in Infectious Diseases (D4) AU - Taubenberger, Jeffery K Y1 - 2008/04/08/ PY - 2008 DA - 2008 Apr 08 KW - Influenza KW - Viruses KW - Influenza A KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40824698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Molecular+Evolution+as+a+Driving+Force+in+Infectious+Diseases+%28D4%29&rft.atitle=The+Evolutionary+Dynamics+of+Influenza+A+Viruses&rft.au=Taubenberger%2C+Jeffery+K&rft.aulast=Taubenberger&rft.aufirst=Jeffery&rft.date=2008-04-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Molecular+Evolution+as+a+Driving+Force+in+Infectious+Diseases+%28D4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 7&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epigenetic Genome Control by RNAi and Transposon-Derived Proteins T2 - 2008 Keystone Symposia on Molecular Basis for Chromatin Modifications and Epigenetic Phenomena (D3) AN - 40823598; 4802614 JF - 2008 Keystone Symposia on Molecular Basis for Chromatin Modifications and Epigenetic Phenomena (D3) AU - Grewal, Shiv I S Y1 - 2008/04/07/ PY - 2008 DA - 2008 Apr 07 KW - Genomes KW - RNA-mediated interference KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40823598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Molecular+Basis+for+Chromatin+Modifications+and+Epigenetic+Phenomena+%28D3%29&rft.atitle=Epigenetic+Genome+Control+by+RNAi+and+Transposon-Derived+Proteins&rft.au=Grewal%2C+Shiv+I+S&rft.aulast=Grewal&rft.aufirst=Shiv+I&rft.date=2008-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Molecular+Basis+for+Chromatin+Modifications+and+Epigenetic+Phenomena+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=95 1&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combinatorial Patterns of Histone Acetylations and Methylations in the Human Genome T2 - 2008 Keystone Symposia on Molecular Basis for Chromatin Modifications and Epigenetic Phenomena (D3) AN - 40820935; 4802597 JF - 2008 Keystone Symposia on Molecular Basis for Chromatin Modifications and Epigenetic Phenomena (D3) AU - Wang, Zhibin Y1 - 2008/04/07/ PY - 2008 DA - 2008 Apr 07 KW - Methylation KW - Genomes KW - Histones KW - Acetylation KW - DNA methylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40820935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Molecular+Basis+for+Chromatin+Modifications+and+Epigenetic+Phenomena+%28D3%29&rft.atitle=Combinatorial+Patterns+of+Histone+Acetylations+and+Methylations+in+the+Human+Genome&rft.au=Wang%2C+Zhibin&rft.aulast=Wang&rft.aufirst=Zhibin&rft.date=2008-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Molecular+Basis+for+Chromatin+Modifications+and+Epigenetic+Phenomena+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=95 1&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Screening for Estrogen Receptor a (ERa) Ligands Using Nuclear Translocation Analysis T2 - 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences AN - 40958931; 4869571 JF - 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences AU - Dull, Angie AU - Martinez, Elisabeth D AU - Hager, Gordon L AU - James, B Y1 - 2008/04/06/ PY - 2008 DA - 2008 Apr 06 KW - Translocation KW - Estrogen receptors KW - Nuclear transport KW - Screening KW - Sex hormones KW - Ligands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40958931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Conference+and+Exhibition+of+the+Society+for+Biomolecular+Sciences&rft.atitle=Screening+for+Estrogen+Receptor+a+%28ERa%29+Ligands+Using+Nuclear+Translocation+Analysis&rft.au=Dull%2C+Angie%3BMartinez%2C+Elisabeth+D%3BHager%2C+Gordon+L%3BJames%2C+B&rft.aulast=Dull&rft.aufirst=Angie&rft.date=2008-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Conference+and+Exhibition+of+the+Society+for+Biomolecular+Sciences&rft.issn=&rft_id=info:doi/ L2 - http://www.sbsonline.org/sbscon/2008/pdf/Poster_guide.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of Cytochrome P450 Activity Across Known Drugs and Diverse Compound Collections T2 - 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences AN - 40955946; 4869409 JF - 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences AU - Veith, Henrike AU - Southall, Noel AU - Huang, Ruili AU - Inglese, James AU - Austin, Christopher AU - Auld, Douglas Y1 - 2008/04/06/ PY - 2008 DA - 2008 Apr 06 KW - Cytochrome P450 KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40955946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Conference+and+Exhibition+of+the+Society+for+Biomolecular+Sciences&rft.atitle=Distribution+of+Cytochrome+P450+Activity+Across+Known+Drugs+and+Diverse+Compound+Collections&rft.au=Veith%2C+Henrike%3BSouthall%2C+Noel%3BHuang%2C+Ruili%3BInglese%2C+James%3BAustin%2C+Christopher%3BAuld%2C+Douglas&rft.aulast=Veith&rft.aufirst=Henrike&rft.date=2008-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Conference+and+Exhibition+of+the+Society+for+Biomolecular+Sciences&rft.issn=&rft_id=info:doi/ L2 - http://www.sbsonline.org/sbscon/2008/pdf/Poster_guide.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Quantitative High-Throughput Screen for LMNA Splicing Modulators T2 - 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences AN - 40954166; 4869679 JF - 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences AU - Tanega, Cordelle AU - Auld, Douglas AU - Scaffidi, Paola AU - Southall, Noel AU - Michael, Sam AU - Inglese, James AU - Austin, Christopher AU - Misteli, Tom Y1 - 2008/04/06/ PY - 2008 DA - 2008 Apr 06 KW - Splicing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40954166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Conference+and+Exhibition+of+the+Society+for+Biomolecular+Sciences&rft.atitle=A+Quantitative+High-Throughput+Screen+for+LMNA+Splicing+Modulators&rft.au=Tanega%2C+Cordelle%3BAuld%2C+Douglas%3BScaffidi%2C+Paola%3BSouthall%2C+Noel%3BMichael%2C+Sam%3BInglese%2C+James%3BAustin%2C+Christopher%3BMisteli%2C+Tom&rft.aulast=Tanega&rft.aufirst=Cordelle&rft.date=2008-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ L2 - http://www.sbsonline.org/sbscon/2008/pdf/Poster_guide.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanistic Evaluation of Natural Product Inhibitors of HIV-1 RNase T2 - 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences AN - 40954053; 4869675 JF - 14th Annual Conference and Exhibition of the Society for Biomolecular Sciences AU - Bermingham, Alun AU - Bokesch, Heidi AU - Beutler, John A AU - LeGrice, Stuart F J AU - McMahon, James B AU - OKeefe, Barry R Y1 - 2008/04/06/ PY - 2008 DA - 2008 Apr 06 KW - Ribonuclease KW - Natural products KW - Inhibitors KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40954053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Conference+and+Exhibition+of+the+Society+for+Biomolecular+Sciences&rft.atitle=Mechanistic+Evaluation+of+Natural+Product+Inhibitors+of+HIV-1+RNase&rft.au=Bermingham%2C+Alun%3BBokesch%2C+Heidi%3BBeutler%2C+John+A%3BLeGrice%2C+Stuart+F+J%3BMcMahon%2C+James+B%3BOKeefe%2C+Barry+R&rft.aulast=Bermingham&rft.aufirst=Alun&rft.date=2008-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Conference+and+Exhibition+of+the+Society+for+Biomolecular+Sciences&rft.issn=&rft_id=info:doi/ L2 - http://www.sbsonline.org/sbscon/2008/pdf/Poster_guide.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeted Immune Approaches to Destroy Endogenous Beta Cells: Origin, Regulation, and Detection of Regenerative beta Cell Responses during Autoimmune Diabetes T2 - 2008 Keystone Symposia on Islet and Beta Cell Development and Transplantation (Z4) AN - 40809185; 4802531 JF - 2008 Keystone Symposia on Islet and Beta Cell Development and Transplantation (Z4) AU - Pechhold, Klaus Ulrich Y1 - 2008/04/06/ PY - 2008 DA - 2008 Apr 06 KW - Diabetes mellitus KW - Beta cells KW - Autoimmune diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Islet+and+Beta+Cell+Development+and+Transplantation+%28Z4%29&rft.atitle=Targeted+Immune+Approaches+to+Destroy+Endogenous+Beta+Cells%3A+Origin%2C+Regulation%2C+and+Detection+of+Regenerative+beta+Cell+Responses+during+Autoimmune+Diabetes&rft.au=Pechhold%2C+Klaus+Ulrich&rft.aulast=Pechhold&rft.aufirst=Klaus&rft.date=2008-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Islet+and+Beta+Cell+Development+and+Transplantation+%28Z4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=92 1&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Techniques Suggest Limited Beta Cell Turnover in Adult Humans T2 - 2008 Keystone Symposia on Islet and Beta Cell Development and Transplantation (Z4) AN - 40809149; 4802521 JF - 2008 Keystone Symposia on Islet and Beta Cell Development and Transplantation (Z4) AU - Perl, Shira Y Y1 - 2008/04/06/ PY - 2008 DA - 2008 Apr 06 KW - Beta cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Islet+and+Beta+Cell+Development+and+Transplantation+%28Z4%29&rft.atitle=Novel+Techniques+Suggest+Limited+Beta+Cell+Turnover+in+Adult+Humans&rft.au=Perl%2C+Shira+Y&rft.aulast=Perl&rft.aufirst=Shira&rft.date=2008-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Islet+and+Beta+Cell+Development+and+Transplantation+%28Z4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=92 1&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Status of Clinical Trials Testing Beta Cell Regeneration T2 - 2008 Keystone Symposia on Islet and Beta Cell Development and Transplantation (Z4) AN - 40807303; 4802538 JF - 2008 Keystone Symposia on Islet and Beta Cell Development and Transplantation (Z4) AU - Harlan, David M Y1 - 2008/04/06/ PY - 2008 DA - 2008 Apr 06 KW - Clinical trials KW - Regeneration KW - Beta cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Islet+and+Beta+Cell+Development+and+Transplantation+%28Z4%29&rft.atitle=Status+of+Clinical+Trials+Testing+Beta+Cell+Regeneration&rft.au=Harlan%2C+David+M&rft.aulast=Harlan&rft.aufirst=David&rft.date=2008-04-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Islet+and+Beta+Cell+Development+and+Transplantation+%28Z4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=92 1&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurobiology and Treatment of Cocaine Dependence T2 - 16th European Congress of Psychiatry (AEP 2008) AN - 40812625; 4800347 JF - 16th European Congress of Psychiatry (AEP 2008) AU - Gorelick, D A Y1 - 2008/04/05/ PY - 2008 DA - 2008 Apr 05 KW - Cocaine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40812625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+European+Congress+of+Psychiatry+%28AEP+2008%29&rft.atitle=Neurobiology+and+Treatment+of+Cocaine+Dependence&rft.au=Gorelick%2C+D+A&rft.aulast=Gorelick&rft.aufirst=D&rft.date=2008-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+European+Congress+of+Psychiatry+%28AEP+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/aep/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enamel Defects in Methylmalonic Acidemia T2 - 37th Annual Meeting and Exhibition of American Association for Dental Research (AADR 2008) AN - 40845350; 4813750 JF - 37th Annual Meeting and Exhibition of American Association for Dental Research (AADR 2008) AU - Bassim, C W AU - Guadagnini, J.-P. AU - Domingo, D L AU - Venditti, C P AU - Hart, T C Y1 - 2008/04/03/ PY - 2008 DA - 2008 Apr 03 KW - Enamel KW - Defects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exhibition+of+American+Association+for+Dental+Research+%28AADR+2008%29&rft.atitle=Enamel+Defects+in+Methylmalonic+Acidemia&rft.au=Bassim%2C+C+W%3BGuadagnini%2C+J.-P.%3BDomingo%2C+D+L%3BVenditti%2C+C+P%3BHart%2C+T+C&rft.aulast=Bassim&rft.aufirst=C&rft.date=2008-04-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exhibition+of+American+Association+for+Dental+Research+%28AADR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Dallas/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Anthrax 2 Expression in Gingiva and Skin T2 - 37th Annual Meeting and Exhibition of American Association for Dental Research (AADR 2008) AN - 40844433; 4814600 JF - 37th Annual Meeting and Exhibition of American Association for Dental Research (AADR 2008) AU - Muralidharan, R AU - Hart, P S AU - Jang, S I AU - Pallos, D AU - Lee, S K AU - Hart, T C Y1 - 2008/04/03/ PY - 2008 DA - 2008 Apr 03 KW - Anthrax KW - Skin KW - Gingiva KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Effects+of+acute+and+repeated+administration+of+salvinorin+A+on+dopamine+function+in+the+rat+dorsal+striatum.&rft.au=Gehrke%2C+Brenda+J%3BChefer%2C+Vladimir+I%3BShippenberg%2C+Toni+S&rft.aulast=Gehrke&rft.aufirst=Brenda&rft.date=2008-04-01&rft.volume=197&rft.issue=3&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-007-1067-6 L2 - http://iadr.confex.com/iadr/2008Dallas/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Apoptosis in Transgenic Mouse Model of Tricho-dento-Osseous Syndrome T2 - 37th Annual Meeting and Exhibition of American Association for Dental Research (AADR 2008) AN - 40838428; 4814354 JF - 37th Annual Meeting and Exhibition of American Association for Dental Research (AADR 2008) AU - Choi, S J AU - Feng, J Q AU - Hart, T C Y1 - 2008/04/03/ PY - 2008 DA - 2008 Apr 03 KW - Animal models KW - Apoptosis KW - Transgenic mice KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exhibition+of+American+Association+for+Dental+Research+%28AADR+2008%29&rft.atitle=Increased+Apoptosis+in+Transgenic+Mouse+Model+of+Tricho-dento-Osseous+Syndrome&rft.au=Choi%2C+S+J%3BFeng%2C+J+Q%3BHart%2C+T+C&rft.aulast=Choi&rft.aufirst=S&rft.date=2008-04-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exhibition+of+American+Association+for+Dental+Research+%28AADR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2008Dallas/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - PPAR alpha : Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators AN - 20660342; 8185029 AB - Peroxisome proliferator chemicals are classic non-genotoxic carcinogens. These agents cause liver cancers when chronically administered to rats and mice. Peroxisome proliferators include the widely prescribed lipid and cholesterol lowering fibrate drugs. In contrast to the results in rodents, there is no evidence that fibrates are associated with elevated risk of liver cancer or any other neoplasms in humans thus indicating a species difference in the hepatocarcinogenic response. The biological effects of peroxisome proliferators are mediated by the peroxisome proliferator-activated receptor (PPAR) alpha . Ppar alpha -null mice are resistant to all of the pleiotropic effects of peroxisome proliferators, including cell proliferation and hepatocarcinogenesis. The mechanism of hepatocellular proliferation involves downregulation of the microRNA let-7c gene by PPAR alpha . Let-7c controls levels of proliferative c-myc by destabilizing its mRNA. Thus, upon suppression of let-7c, c-myc mRNA and protein are elevated resulting in enhanced hepatocellular proliferation. In contrast, PPAR alpha -humanized mice, that respond to Wy-14,643 by lower serum triglycerides and induction of genes encoding fatty acid metabolizing enzymes, are resistant to peroxisome proliferator-induced cell proliferation and cancer. These mice do not exhibit downregulation of let-7c gene expression thus forming the basis for the resistance to hepatocellular carcinogenesis. JF - Toxicology AU - Gonzalez, F J AU - Shah, Y M AD - Center for Cancer Research, National Cancer Research, National Institutes of Health, Bethesda, MD 20892, United States, fjgonz@helix.nih.gov Y1 - 2008/04/03/ PY - 2008 DA - 2008 Apr 03 SP - 2 EP - 8 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 246 IS - 1 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Peroxisome proliferator-activated receptors KW - Lipids KW - Liver cancer KW - miRNA KW - Enzymes KW - Cholesterol KW - Carcinogens KW - Gene expression KW - Triglycerides KW - Carcinogenesis KW - Fatty acids KW - Cell proliferation KW - c-Myc protein KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20660342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=PPAR+alpha+%3A+Mechanism+of+species+differences+and+hepatocarcinogenesis+of+peroxisome+proliferators&rft.au=Gonzalez%2C+F+J%3BShah%2C+Y+M&rft.aulast=Gonzalez&rft.aufirst=F&rft.date=2008-04-03&rft.volume=246&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.09.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Peroxisome proliferator-activated receptors; Liver cancer; Lipids; miRNA; Enzymes; Carcinogens; Cholesterol; Gene expression; Triglycerides; Carcinogenesis; Fatty acids; Cell proliferation; c-Myc protein DO - http://dx.doi.org/10.1016/j.tox.2007.09.030 ER - TY - JOUR T1 - Rapid clearance of human papillomavirus and implications for clinical focus on persistent infections. AN - 70460525; 18364507 AB - Health professionals and the public need to understand the natural history of human papillomavirus (HPV) infections of the cervix to best use the information provided by new molecular screening tests. We investigated outcomes of 800 carcinogenic HPV infections detected in 599 women at enrollment into a population-based cohort (Guanacaste, Costa Rica). For individual infections, we calculated cumulative proportions of three outcomes (viral clearance, persistence without cervical intraepithelial neoplasia grade 2 or worse [CIN2+], or persistence with new diagnosis of CIN2+) at successive 6-month time points for the first 30 months of follow-up. Cervical specimens were tested for carcinogenic HPV genotypes using an L1 degenerate-primer polymerase chain reaction method. Infections typically cleared rapidly, with 67% (95% confidence interval [CI] = 63% to 70%) clearing by 12 months. However, among infections that persisted at least 12 months, the risk of CIN2+ diagnosis by 30 months was 21% (95% CI = 15% to 28%). The risk of CIN2+ diagnosis was highest among women younger than 30 years with HPV-16 infections that persisted for at least 12 months (53%; 95% CI = 29% to 76%). These findings suggest that the medical community should emphasize persistence of cervical HPV infection, not single-time detection of HPV, in management strategies and health messages. JF - Journal of the National Cancer Institute AU - Rodríguez, Ana Cecilia AU - Schiffman, Mark AU - Herrero, Rolando AU - Wacholder, Sholom AU - Hildesheim, Allan AU - Castle, Philip E AU - Solomon, Diane AU - Burk, Robert AU - Proyecto Epidemiológico Guanacaste Group AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Rm 5032, Rockville, MD 20852, USA. rodrigac@mail.nih.gov ; Proyecto Epidemiológico Guanacaste Group Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 SP - 513 EP - 517 VL - 100 IS - 7 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Viral Load KW - Polymerase Chain Reaction KW - Age Factors KW - Humans KW - Costa Rica KW - Adult KW - Vaginal Smears KW - Middle Aged KW - DNA, Viral -- isolation & purification KW - Cytopathogenic Effect, Viral KW - Female KW - Colposcopy KW - Cell Transformation, Viral KW - Cell Transformation, Neoplastic KW - Cervix Uteri -- pathology KW - Alphapapillomavirus -- genetics KW - Tumor Virus Infections -- virology KW - Alphapapillomavirus -- isolation & purification KW - Papillomavirus Infections -- complications KW - Papillomavirus Infections -- virology KW - Cervix Uteri -- virology KW - Cervical Intraepithelial Neoplasia -- virology KW - Uterine Cervical Neoplasms -- virology KW - Tumor Virus Infections -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70460525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Rapid+clearance+of+human+papillomavirus+and+implications+for+clinical+focus+on+persistent+infections.&rft.au=Rodr%C3%ADguez%2C+Ana+Cecilia%3BSchiffman%2C+Mark%3BHerrero%2C+Rolando%3BWacholder%2C+Sholom%3BHildesheim%2C+Allan%3BCastle%2C+Philip+E%3BSolomon%2C+Diane%3BBurk%2C+Robert%3BProyecto+Epidemiol%C3%B3gico+Guanacaste+Group&rft.aulast=Rodr%C3%ADguez&rft.aufirst=Ana&rft.date=2008-04-02&rft.volume=100&rft.issue=7&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjn044 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-09 N1 - Date created - 2008-04-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Virol. 2002 Nov;68(3):417-23 [12226831] Am J Obstet Gynecol. 2007 Oct;197(4):356.e1-6 [17904958] J Clin Pathol. 2004 Jan;57(1):68-72 [14693839] Rev Panam Salud Publica. 2004 Feb;15(2):75-89 [15030652] J Clin Microbiol. 1997 Jun;35(6):1304-10 [9163434] Rev Panam Salud Publica. 1997 May;1(5):362-75 [9180057] J Gen Virol. 1999 Sep;80 ( Pt 9):2437-43 [10501499] J Infect Dis. 2005 Jan 15;191(2):182-92 [15609227] J Infect Dis. 2005 Jun 1;191(11):1796-807 [15871111] Virology. 2005 Jun 20;337(1):76-84 [15914222] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Lancet. 2006 Feb 11;367(9509):489-98 [16473126] Vaccine. 2006 Mar 30;24 Suppl 1:S1-15 [16406226] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):288-94 [17267388] JAMA. 2007 Feb 28;297(8):813-9 [17327523] J Med Screen. 2007;14(1):29-33 [17362569] Sex Transm Infect. 2007 Apr;83(2):155-9 [17098767] Acta Obstet Gynecol Scand. 2007;86(5):596-603 [17464590] J Infect Dis. 2007 Jun 1;195(11):1582-9 [17471427] J Infect Dis. 2007 Jul 1;196(1):76-81 [17538886] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] Sex Transm Dis. 2003 Jul;30(7):581-7 [12838088] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djn044 ER - TY - CPAPER T1 - Urinary Markers for Progressive Renal Fibrosis T2 - 2008 Spring Clinical Meetings of the National Kidney Foundation (CM 2008) AN - 40922780; 4846475 JF - 2008 Spring Clinical Meetings of the National Kidney Foundation (CM 2008) AU - Bitzer, M AU - Shang, H AU - Lim, J AU - Ju, W. AU - Kopp, J B AU - Hostetter, T H AU - Angeletti, R H Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Urine KW - Fibrosis KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40922780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Spring+Clinical+Meetings+of+the+National+Kidney+Foundation+%28CM+2008%29&rft.atitle=Urinary+Markers+for+Progressive+Renal+Fibrosis&rft.au=Bitzer%2C+M%3BShang%2C+H%3BLim%2C+J%3BJu%2C+W.%3BKopp%2C+J+B%3BHostetter%2C+T+H%3BAngeletti%2C+R+H&rft.aulast=Bitzer&rft.aufirst=M&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Spring+Clinical+Meetings+of+the+National+Kidney+Foundation+%28CM+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kidney.org/news/meetings/clinical/CM08_Abstracts.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cox Inhibitors Downregulate PDE4D Expression in a Clinical Model of Inflammatory Pain T2 - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AN - 40910945; 4847478 JF - 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2008) AU - Wang, X AU - Hamza, M AU - Gordon, S M AU - Wahl, S M AU - Dionne, R A Y1 - 2008/04/02/ PY - 2008 DA - 2008 Apr 02 KW - Pain KW - Phosphodiesterase KW - Inflammation KW - Models KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40910945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.atitle=Cox+Inhibitors+Downregulate+PDE4D+Expression+in+a+Clinical+Model+of+Inflammatory+Pain&rft.au=Wang%2C+X%3BHamza%2C+M%3BGordon%2C+S+M%3BWahl%2C+S+M%3BDionne%2C+R+A&rft.aulast=Wang&rft.aufirst=X&rft.date=2008-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=109th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2008/2008_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Respiratory and laryngeal function during spontaneous speaking in teachers with voice disorders. AN - 85411592; pmid-18367681 AB - To determine if respiratory and laryngeal function during spontaneous speaking were different for teachers with voice disorders compared with teachers without voice problems.Eighteen teachers, 9 with and 9 without voice disorders, were included in this study. Respiratory function was measured with magnetometry, and laryngeal function was measured with electroglottography during 3 spontaneous speaking tasks: a simulated teaching task at a typical loudness level, a simulated teaching task at an increased loudness level, and a conversational speaking task. Electroglottography measures were also obtained for 3 structured speaking tasks: a paragraph reading task, a sustained vowel, and a maximum phonation time vowel.Teachers with voice disorders started and ended their breath groups at significantly smaller lung volumes than teachers without voice problems during teaching-related speaking tasks; however, there were no between-group differences in laryngeal measures. Task-related differences were found on several respiratory measures and on one laryngeal measure.These findings suggest that teachers with voice disorders used different speech breathing strategies than teachers without voice problems. Implications for clinical management of teachers with voice disorders are discussed. JF - Journal of speech, language, and hearing research : JSLHR AU - Lowell, Soren Y AU - Barkmeier-Kraemer, Julie M AU - Hoit, Jeannette D AU - Story, Brad H AD - National Institute of Neurological Disorders and Stroke, Laryngeal and Speech Section, Bethesda, MD 20892, USA. lowells@ninds.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 333 EP - 349 VL - 51 IS - 2 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Faculty KW - Female KW - Glottis: physiology KW - Humans KW - Laryngeal Muscles: physiology KW - *Larynx: physiology KW - Lung Volume Measurements KW - Male KW - Middle Aged KW - *Occupational Diseases: physiopathology KW - Reproducibility of Results KW - *Respiratory Mechanics: physiology KW - *Speech: physiology KW - Speech Production Measurement KW - Vocal Cords: physiology KW - *Voice Disorders: physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85411592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=Respiratory+and+laryngeal+function+during+spontaneous+speaking+in+teachers+with+voice+disorders.&rft.au=Lowell%2C+Soren+Y%3BBarkmeier-Kraemer%2C+Julie+M%3BHoit%2C+Jeannette+D%3BStory%2C+Brad+H&rft.aulast=Lowell&rft.aufirst=Soren&rft.date=2008-04-01&rft.volume=51&rft.issue=2&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The Space of an Object: Object Attention Alters the Spatial Gradient in the Surround AN - 742718024; 201010613 AB - Although object-based attention enhances perceptual processing of information appearing within the boundaries of a selected object, little is known about the consequences for information in the object's surround. The authors show that distance from an attended object's center of mass determines reaction time (RT) to targets in the surround. Of 2 targets in the surround, both equidistant from a cue, the target closer to the center of mass was detected faster. Moreover, RT was shown to be a linear function of distance from the center of mass of a fixed, attended object, and changes to the shape of the object and its center of mass predictably altered RT. Object-based attention leads to a pattern of facilitation in the surround that may contribute to the organization of visual scenes. [Copyright American Psychological Association] JF - Journal of Experimental Psychology: Human Perception and Performance AU - Kravitz, Dwight Jacob AU - Behrmann, Marlene AD - Department of Psychology, Carnegie Mellon University kravitz@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 298 EP - 309 PB - American Psychological Association, Washington DC VL - 34 IS - 2 SN - 0096-1523, 0096-1523 KW - object-based attention spatial attention attentional gradients visual perception KW - Reaction times KW - Facilitation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742718024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Psychology%3A+Human+Perception+and+Performance&rft.atitle=The+Space+of+an+Object%3A+Object+Attention+Alters+the+Spatial+Gradient+in+the+Surround&rft.au=Kravitz%2C+Dwight+Jacob%3BBehrmann%2C+Marlene&rft.aulast=Kravitz&rft.aufirst=Dwight&rft.date=2008-04-01&rft.volume=34&rft.issue=2&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Psychology%3A+Human+Perception+and+Performance&rft.issn=00961523&rft_id=info:doi/10.1037%2F0096-1523.34.2.298 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JPHPDH N1 - SubjectsTermNotLitGenreText - Facilitation; Reaction times DO - http://dx.doi.org/10.1037/0096-1523.34.2.298 ER - TY - JOUR T1 - Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies. AN - 71635339; 18441259 AB - The lung is the second most common target site of neoplasia of chemicals tested by the National Toxicology Program (NTP). Of all peer-reviewed NTP studies to date (N = 545), a total of sixty-four chemicals in sixty-six reports produced significant site-specific neoplasia in the lungs of rats and/or mice. Of the studies associated with lung tumor induction, approximately 35% were inhalation and 35% were gavage studies, with dosed-feed, dosed-water, topical, intraperitoneal, or in utero routes of chemical administration accounting for 18%, 6%, 3%, 1%, and 1% of the studies, respectively. The most commonly induced lung tumors were alveolar/bronchiolar (A/B) adenoma and/or carcinoma for both species. The most frequently observed nonneoplastic lesions included hyperplasia and inflammation in both species. The liver was the most common primary site of origin of metastatic lesions to the lungs of mice; however, skin was most often the primary site of origin of metastatic lesions to the lungs of rats. In summary, A/B adenoma and carcinoma were the most frequently diagnosed chemically induced tumors in the lungs of both rats and mice in the NTP toxicology and carcinogenesis bioassays, and hyperplasia and inflammation were the most common nonneoplastic changes observed. JF - Toxicologic pathology AU - Dixon, Darlene AU - Herbert, Ronald A AU - Kissling, Grace E AU - Brix, Amy E AU - Miller, Rodney A AU - Maronpot, Robert R AD - Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. dixon@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 428 EP - 439 VL - 36 IS - 3 KW - Carcinogens KW - 0 KW - Xenobiotics KW - Index Medicus KW - Animals KW - Hyperplasia -- pathology KW - Carcinoma, Hepatocellular -- secondary KW - Liver Neoplasms -- chemically induced KW - Mice KW - Liver Neoplasms -- secondary KW - Skin Neoplasms -- secondary KW - Rats KW - Rats, Inbred F344 KW - Hyperplasia -- chemically induced KW - Skin Neoplasms -- chemically induced KW - Carcinogenicity Tests KW - Carcinoma, Hepatocellular -- chemically induced KW - Female KW - Male KW - Adenocarcinoma -- chemically induced KW - Neoplasms, Experimental -- chemically induced KW - Lung Neoplasms -- secondary KW - Adenoma -- chemically induced KW - Carcinogens -- toxicity KW - Adenocarcinoma -- secondary KW - Xenobiotics -- toxicity KW - Lung Neoplasms -- chemically induced KW - Neoplasms, Experimental -- pathology KW - Adenoma -- pathology KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71635339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Summary+of+chemically+induced+pulmonary+lesions+in+the+National+Toxicology+Program+%28NTP%29+toxicology+and+carcinogenesis+studies.&rft.au=Dixon%2C+Darlene%3BHerbert%2C+Ronald+A%3BKissling%2C+Grace+E%3BBrix%2C+Amy+E%3BMiller%2C+Rodney+A%3BMaronpot%2C+Robert+R&rft.aulast=Dixon&rft.aufirst=Darlene&rft.date=2008-04-01&rft.volume=36&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308315360 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2004 Apr 1;64(7):2307-16 [15059877] Exp Toxicol Pathol. 2006 Aug;58(1):13-20 [16806863] Lab Invest. 1980 Jul;43(1):28-36 [7392573] Am J Pathol. 1981 May;103(2):174-80 [7234960] Cancer Lett. 1983 Apr;18(3):311-6 [6850563] Am J Pathol. 1985 Mar;118(3):493-9 [3883798] Cancer Res. 1985 Jun;45(6):2785-92 [3886137] Am J Pathol. 1989 Jan;134(1):79-87 [2464284] Exp Lung Res. 1991 Mar-Apr;17(2):263-78 [2050030] Toxicol Pathol. 1991;19(4 Pt 1):540-56 [1813992] Vet Pathol. 1994 May;31(3):366-74 [8053132] Environ Health Perspect. 1995 Nov;103 Suppl 8:143-8 [8741774] Toxicol Pathol. 1996 Sep-Oct;24(5):564-72 [8923677] Prev Med. 1997 Jul-Aug;26(4):451-6 [9245665] Exp Toxicol Pathol. 1997 Dec;49(6):433-46 [9495643] Toxicol Pathol. 1998 Mar-Apr;26(2):298-300 [9547872] Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):576-81 [15767332] Natl Toxicol Program Tech Rep Ser. 2006 Jan;(520):4-246 [16628245] Natl Toxicol Program Tech Rep Ser. 2006 Apr;(521):4-232 [16835633] Lab Invest. 1979 Jun;40(6):708-16 [449277] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623308315360 ER - TY - JOUR T1 - [Current situation of and the political measures for drug abuse/dependence]. AN - 71627444; 18516951 AB - More than 10 years has passed since 1995 when the third epidemic of methamphetamine abuse started in Japan. We are now still in the third epidemic of methamphetamine abuse, thought the current situation of drug abuse/dependence has obviously changed from previously. Considering several kinds of nationwide surveys and censuses, the authors summarized the change as follows: a) obvious decrease in solvent abuse/dependence, b) stabilization of methamphetamine abuse/dependence, c) increase in abuse of such drugs as cannabis or MDMA which don't have high potential to cause drug-induced psychosis, and d) emergence of non-regulatory drugs represented by designer drugs. These imply the change a) from "hard drugs" to "soft drugs", b) from Japanese unique situation which is symbolized by solvent abuse to Western situation which is symbolized by cannabis abuse, and c) from "illicit drugs" to "non-regulatory drugs". These characteristics reveal that there is the limitation to the Japanese Government policy which has tried to control the drug issue mainly as criminal cases for many years and that it is time now to change its policy. The authors stress the necessities of development of medical treatment targeting drug dependence and of its social support system. JF - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence AU - Wada, Kiyoshi AU - Ozaki, Shigeru AU - Kondo, Ayumi AD - Department of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8553, Japan. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 120 EP - 131 VL - 43 IS - 2 SN - 1341-8963, 1341-8963 KW - Index Medicus KW - Japan -- epidemiology KW - Age Factors KW - Humans KW - Adult KW - Aged KW - Social Support KW - Middle Aged KW - Adolescent KW - Time Factors KW - Psychoses, Substance-Induced -- epidemiology KW - Male KW - Female KW - Crime -- legislation & jurisprudence KW - Drug and Narcotic Control -- legislation & jurisprudence KW - Crime -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71627444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.atitle=%5BCurrent+situation+of+and+the+political+measures+for+drug+abuse%2Fdependence%5D.&rft.au=Wada%2C+Kiyoshi%3BOzaki%2C+Shigeru%3BKondo%2C+Ayumi&rft.aulast=Wada&rft.aufirst=Kiyoshi&rft.date=2008-04-01&rft.volume=43&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.issn=13418963&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-06-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. AN - 70787333; 18426259 AB - To present nationally representative findings on prevalence, sociodemographic correlates, disability, and comorbidity of borderline personality disorder (BPD) among men and women. Face-to-face interviews were conducted with 34,653 adults participating in the 2004-2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Personality disorder diagnoses were made using the Wave 2 Alcohol Use Disorder and Associated Disabilities Interview Schedule-DSM-IV Version. Prevalence of lifetime BPD was 5.9% (99% CI = 5.4 to 6.4). There were no differences in the rates of BPD among men (5.6%, 99% CI = 5.0 to 6.2) and women (6.2%, 99% CI = 5.6 to 6.9). BPD was more prevalent among Native American men, younger and separated/divorced/widowed adults, and those with lower incomes and education and was less prevalent among Hispanic men and women and Asian women. BPD was associated with substantial mental and physical disability, especially among women. High co-occurrence rates of mood and anxiety disorders with BPD were similar. With additional comorbidity controlled for, associations with bipolar disorder and schizotypal and narcissistic personality disorders remained strong and significant (odds ratios > or = 4.3). Associations of BPD with other specific disorders were no longer significant or were considerably weakened. BPD is much more prevalent in the general population than previously recognized, is equally prevalent among men and women, and is associated with considerable mental and physical disability, especially among women. Unique and common factors may differentially contribute to disorder-specific comorbidity with BPD, and some of these associations appear to be sex-specific. There is a need for future epidemiologic, clinical, and genetically informed studies to identify unique and common factors that underlie disorder-specific comorbidity with BPD. Important sex differences observed in rates of BPD and associations with BPD can inform more focused, hypothesis-driven investigations of these factors. JF - The Journal of clinical psychiatry AU - Grant, Bridget F AU - Chou, S Patricia AU - Goldstein, Risë B AU - Huang, Boji AU - Stinson, Frederick S AU - Saha, Tulshi D AU - Smith, Sharon M AU - Dawson, Deborah A AU - Pulay, Attila J AU - Pickering, Roger P AU - Ruan, W June AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. bgrant@willco.niaaa.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 533 EP - 545 VL - 69 IS - 4 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Comorbidity KW - Prevalence KW - Mood Disorders -- diagnosis KW - Anxiety Disorders -- diagnosis KW - Borderline Personality Disorder -- diagnosis KW - Borderline Personality Disorder -- epidemiology KW - Alcohol-Related Disorders -- diagnosis KW - Substance-Related Disorders -- diagnosis KW - Surveys and Questionnaires KW - Disability Evaluation KW - Anxiety Disorders -- epidemiology KW - Mood Disorders -- epidemiology KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcohol-Related Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70787333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Prevalence%2C+correlates%2C+disability%2C+and+comorbidity+of+DSM-IV+borderline+personality+disorder%3A+results+from+the+Wave+2+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Grant%2C+Bridget+F%3BChou%2C+S+Patricia%3BGoldstein%2C+Ris%C3%AB+B%3BHuang%2C+Boji%3BStinson%2C+Frederick+S%3BSaha%2C+Tulshi+D%3BSmith%2C+Sharon+M%3BDawson%2C+Deborah+A%3BPulay%2C+Attila+J%3BPickering%2C+Roger+P%3BRuan%2C+W+June&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2008-04-01&rft.volume=69&rft.issue=4&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-05-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Drug Alcohol Depend. 1997 Sep 25;47(3):217-26 [9306047] J Subst Abuse. 1997;9:127-35 [9494944] J Pers Disord. 1998 Summer;12(2):95-118 [9661097] Compr Psychiatry. 1998 Sep-Oct;39(5):296-302 [9777282] J Clin Epidemiol. 1998 Nov;51(11):1149-58 [9817132] Am J Psychiatry. 1998 Dec;155(12):1733-9 [9842784] Eur Addict Res. 1998 Dec;4(4):144-9 [9852366] Alcohol Clin Exp Res. 1999 Jan;23(1):144-50 [10029216] Compr Psychiatry. 1999 Jul-Aug;40(4):245-52 [10428182] Soc Psychiatry Psychiatr Epidemiol. 2004 Oct;39(10):765-76 [15669657] J Clin Psychiatry. 2005 Jun;66(6):677-85 [15960559] Am J Psychiatry. 2005 Oct;162(10):1911-8 [16199838] Arch Gen Psychiatry. 2005 Oct;62(10):1097-106 [16203955] J Clin Psychiatry. 2005 Oct;66(10):1205-15 [16259532] J Pers Disord. 2005 Oct;19(5):505-23 [16274279] Psychol Med. 2005 Dec;35(12):1747-59 [16202187] J Clin Psychiatry. 2005 Nov;66(11):1351-61 [16420070] Compr Psychiatry. 2006 May-Jun;47(3):178-84 [16635645] J Nerv Ment Dis. 2002 Aug;190(8):552-4 [12193841] Am J Psychiatry. 2003 Feb;160(2):274-83 [12562573] Alcohol Clin Exp Res. 2003 Feb;27(2):244-52 [12605073] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Compr Psychiatry. 2003 Jul-Aug;44(4):284-92 [12923706] Compr Psychiatry. 2003 Nov-Dec;44(6):483-91 [14610727] Psychiatr Q. 2003 Winter;74(4):349-60 [14686459] J Pers Disord. 2004 Jun;18(3):215-25 [15237042] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Clin Psychiatry. 2004 Jul;65(7):948-58 [15291684] J Psychiatr Res. 2005 Jan;39(1):1-9 [15504418] Am J Psychiatry. 1984 Sep;141(9):1080-4 [6465385] Am J Psychiatry. 1985 Feb;142(2):207-12 [3970245] Acta Psychiatr Scand Suppl. 1986;328:61-7 [3463140] Can J Psychiatry. 1988 Jun;33(5):336-40 [3409151] J Consult Clin Psychol. 1987 Oct;55(5):701-11 [3331632] Compr Psychiatry. 1989 Mar-Apr;30(2):149-56 [2920550] Soc Psychiatry Psychiatr Epidemiol. 1989 Jan;24(1):12-6 [2496472] Arch Gen Psychiatry. 1989 Aug;46(8):682-9 [2751402] Am J Psychiatry. 1990 Nov;147(11):1537-41 [2221170] Am J Psychiatry. 1993 Aug;150(8):1226-32 [8328568] Arch Gen Psychiatry. 1994 Mar;51(3):225-45 [8122959] Br J Psychiatry. 1993 May;162:641-50 [8149116] J Clin Psychopharmacol. 1994 Apr;14(2):111-8 [8195451] Am J Psychiatry. 2006 May;163(5):822-6 [16648322] Am J Psychiatry. 2006 May;163(5):827-32 [16648323] Br J Psychiatry. 2006 May;188:423-31 [16648528] J Clin Psychiatry. 2006 Mar;67(3):363-74 [16649821] Psychiatry Res. 2007 Jan 15;149(1-3):169-76 [17157389] Arch Gen Psychiatry. 2007 May;64(5):566-76 [17485608] Psychol Med. 2007 Jul;37(7):1047-59 [17335637] Arch Gen Psychiatry. 2007 Jul;64(7):830-42 [17606817] Biol Psychiatry. 2007 Sep 15;62(6):553-64 [17217923] Drug Alcohol Depend. 2008 Jan 1;92(1-3):27-36 [17706375] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] Addiction. 1999 Jun;94(6):843-55 [10665074] Depress Anxiety. 1999;10(4):175-82 [10690579] Clin Psychol Rev. 2000 Mar;20(2):235-53 [10721499] Acta Psychiatr Scand. 2000 Oct;102(4):256-64 [11089725] Soc Psychiatry Psychiatr Epidemiol. 2000 Dec;35(12):531-8 [11213842] Arch Gen Psychiatry. 2001 Jun;58(6):590-6 [11386989] Am J Psychiatry. 2002 Feb;159(2):276-83 [11823271] J Nerv Ment Dis. 2002 May;190(5):324-30 [12011613] Psychiatr Serv. 2002 Jun;53(6):738-42 [12045312] Am J Psychiatry. 1994 Jul;151(7):1055-62 [8010364] Arch Gen Psychiatry. 1994 Jul;51(7):559-67 [8031229] J Abnorm Psychol. 1994 May;103(2):259-66 [8040495] Addiction. 1994 May;89(5):573-9 [8044123] Bull Menninger Clin. 1994 Spring;58(2 Suppl A):A67-83 [7913851] Am J Psychiatry. 1995 Apr;152(4):571-8 [7694906] Arch Gen Psychiatry. 1995 Apr;52(4):289-95 [7702445] Arch Gen Psychiatry. 1995 Jun;52(6):487-96 [7771919] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Br J Psychiatry. 1995 Sep;167(3):374-9 [7496647] Br J Psychiatry. 1996 Oct;169(4):468-74 [8894198] Am J Psychiatry. 1996 Dec;153(12):1598-606 [8942457] J Clin Psychiatry. 1996 Nov;57(11):519-22 [8968300] J Clin Psychiatry. 1997;58 Suppl 2:20-4; discussion 24-5 [9078990] Drug Alcohol Depend. 1997 Mar 14;44(2-3):133-41 [9088785] Arch Gen Psychiatry. 1997 Apr;54(4):345-51 [9107151] Drug Alcohol Depend. 1997 Sep 25;47(3):161-9 [9306042] Drug Alcohol Depend. 1997 Sep 25;47(3):171-85 [9306043] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] Biol Psychiatry. 2002 Jun 15;51(12):936-50 [12062877] J Pers Disord. 2002 Jun;16(3):277-82 [12136683] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - No evidence for differences in DNA damage assessed before and after a cancer diagnosis. AN - 70482057; 18398043 AB - The overwhelming majority of studies that have found increased cancer risk associated with functional deficits in DNA repair used a case-control design, in which measurements were made after cancer diagnosis. However, there are concerns about whether the cancer itself or cancer treatment affected the conclusions (reverse causation bias). We assessed the effect of cancer diagnosis among 26 breast cancer controls who had blood collected during 2001 to 2003 and again in 2005 to 2006 after being diagnosed with cancer. Using the alkaline comet assay, we quantified DNA damage in untreated lymphoblastoid cell lines. Comet distributed moment, olive tail moment, percentage of DNA in tail, and comet tail length were summarized as the geometric mean of 100 cells. For comet distributed moment, olive tail moment, tail DNA, and tail length, the proportions of women with before diagnosis values higher than after diagnosis were 65%, 50%, 50%, and 46%, respectively. We found no significant differences in the before or after diagnosis mean comet values. Median cut-points were determined from the before diagnosis distribution, and we used conditional logistic regression to calculate odds ratios (OR) and upper 95% bounds of the confidence intervals. ORs ranged from 0.6 to 0.9 with upper confidence interval bounds of 1.9 and 2.6, meaning biased ORs above 2.6 are unlikely. We found no evidence that reverse causation bias is an important concern in case-control studies using the comet assay applied to cell lines collected after cancer diagnosis. More work is needed to characterize the effect of cancer diagnosis on other phenotypic assays. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Bhatti, Parveen AU - Sigurdson, Alice J AU - Thomas, Cynthia B AU - Iwan, Allison AU - Alexander, Bruce H AU - Kampa, Diane AU - Bowen, Laura AU - Doody, Michele Morin AU - Jones, Irene M AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. bhattip@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 990 EP - 994 VL - 17 IS - 4 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Comet Assay KW - Medical Records KW - Aged, 80 and over KW - Humans KW - Case-Control Studies KW - Confidence Intervals KW - Aged KW - Middle Aged KW - Female KW - Neoplasms -- diagnosis KW - DNA Damage KW - Neoplasms -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70482057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=No+evidence+for+differences+in+DNA+damage+assessed+before+and+after+a+cancer+diagnosis.&rft.au=Bhatti%2C+Parveen%3BSigurdson%2C+Alice+J%3BThomas%2C+Cynthia+B%3BIwan%2C+Allison%3BAlexander%2C+Bruce+H%3BKampa%2C+Diane%3BBowen%2C+Laura%3BDoody%2C+Michele+Morin%3BJones%2C+Irene+M&rft.aulast=Bhatti&rft.aufirst=Parveen&rft.date=2008-04-01&rft.volume=17&rft.issue=4&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-07-2871 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Carcinogenesis. 2003 May;24(5):883-9 [12771032] Eur J Cancer. 2004 Feb;40(3):445-51 [14746864] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Cancer Epidemiol Biomarkers Prev. 1994 Mar;3(2):141-4 [8049635] J Natl Cancer Inst. 2005 Jan 19;97(2):127-32 [15657342] Mutat Res. 2005 Oct 3;586(2):173-88 [16099702] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):174-7 [17220349] J Epidemiol Community Health. 2007 Sep;61(9):824-33 [17699539] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2000-7 [17932347] Int J Cancer. 2008 Jan 1;122(1):177-82 [17764108] J Natl Cancer Inst. 2000 Jun 7;92(11):874-97 [10841823] Cancer Lett. 2001 May 26;166(2):155-63 [11311488] Environ Mol Mutagen. 2002;40(2):79-84 [12203399] Mutagenesis. 2002 Nov;17(6):489-93 [12435846] J Natl Cancer Inst. 2003 Apr 2;95(7):540-7 [12671022] J Natl Cancer Inst. 2003 Sep 3;95(17):1263-5 [12953074] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-07-2871 ER - TY - JOUR T1 - Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. AN - 70481829; 18395093 AB - Signal transducer and activator of transcription 3 (STAT3) is known to be activated in human alcoholic liver disease, but its role in the pathogenesis of alcoholic liver injury remains obscure. The role of STAT3 in alcoholic liver injury was investigated in hepatocyte-specific STAT3 knockout (H-STAT3KO) mice and macrophage/neutrophil-specific STAT3 KO (M/N-STAT3KO) mice. Alcoholic liver injury was achieved by feeding mice a liquid diet containing 5% ethanol for up to 8 weeks. Compared with wild-type mice, feeding H-STAT3KO mice with an ethanol-containing diet induced greater hepatic steatosis, hypertriglyceridemia, and hepatic expression of lipogenic genes (sterol regulatory element-binding protein, fatty acid synthase, acetyl-CoA carboxylase-1, and stearoyl-CoA desaturase 1), but less inflammation and lower expression of hepatic proinflammatory cytokines. In contrast, ethanol-fed M/N-STAT3KO mice showed more hepatic inflammation, worse injury, and increased hepatic expression of proinflammatory cytokines compared with wild-type mice. Kupffer cells isolated from ethanol-fed H-STAT3KO mice produced similar amounts of reactive oxygen species and tumor necrosis factor alpha, whereas Kupffer cells from M/N-STAT3KO mice produced more reactive oxygen species and tumor necrosis factor alpha compared with wild-type controls. These findings suggest that STAT3 regulates hepatic inflammation in a cell type-dependent manner during alcoholic liver injury: STAT3 in hepatocytes promotes whereas STAT3 in macrophages/Kupffer cells suppresses inflammation. In addition, activation of hepatocellular STAT3 ameliorates alcoholic fatty liver via inhibition of sterol regulatory element-binding protein 1c expression. JF - Gastroenterology AU - Horiguchi, Norio AU - Wang, Lei AU - Mukhopadhyay, Partha AU - Park, Ogyi AU - Jeong, Won Il AU - Lafdil, Fouad AU - Osei-Hyiaman, Douglas AU - Moh, Akira AU - Fu, Xin Yuan AU - Pacher, Pál AU - Kunos, George AU - Gao, Bin AD - Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 1148 EP - 1158 VL - 134 IS - 4 KW - Antigens, Differentiation KW - 0 KW - Ccr2 protein, mouse KW - Central Nervous System Depressants KW - RNA, Messenger KW - Receptors, CCR2 KW - STAT3 Transcription Factor KW - Stat3 protein, mouse KW - Sterol Regulatory Element Binding Protein 1 KW - monocyte-macrophage differentiation antigen KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - Receptors, CCR2 -- genetics KW - Receptors, CCR2 -- biosynthesis KW - Animals KW - Antigens, Differentiation -- biosynthesis KW - Disease Models, Animal KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Cell Proliferation KW - Sterol Regulatory Element Binding Protein 1 -- biosynthesis KW - Mice, Knockout KW - Blotting, Western KW - Central Nervous System Depressants -- toxicity KW - Sterol Regulatory Element Binding Protein 1 -- genetics KW - Antigens, Differentiation -- genetics KW - Ethanol -- toxicity KW - Chronic Disease KW - Gene Expression Regulation KW - Immunohistochemistry KW - Liver Cirrhosis, Alcoholic -- metabolism KW - Liver Cirrhosis, Alcoholic -- genetics KW - Hepatocytes -- drug effects KW - Liver Cirrhosis, Alcoholic -- pathology KW - Liver Cirrhosis, Experimental -- genetics KW - STAT3 Transcription Factor -- genetics KW - Liver Cirrhosis, Experimental -- metabolism KW - STAT3 Transcription Factor -- metabolism KW - Hepatocytes -- pathology KW - Liver Cirrhosis, Experimental -- pathology KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70481829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pediatrics&rft.atitle=Decreased+bone+mineral+density+with+off-label+use+of+tenofovir+in+children+and+adolescents+infected+with+human+immunodeficiency+virus.&rft.au=Purdy%2C+Julia+B%3BGafni%2C+Rachel+I%3BReynolds%2C+James+C%3BZeichner%2C+Steven%3BHazra%2C+Rohan&rft.aulast=Purdy&rft.aufirst=Julia&rft.date=2008-04-01&rft.volume=152&rft.issue=4&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pediatrics&rft.issn=1097-6833&rft_id=info:doi/10.1016%2Fj.jpeds.2007.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-24 N1 - Date created - 2008-04-08 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: FEBS Lett. 2000 Sep 1;480(2-3):132-6 [11034314] Cell Mol Immunol. 2005 Apr;2(2):92-100 [16191414] Annu Rev Immunol. 2001;19:683-765 [11244051] FASEB J. 2001 Jun;15(8):1335-49 [11387231] Alcohol Clin Exp Res. 2001 Sep;25(9):1360-7 [11584157] Oncogene. 2002 Jan 3;21(1):32-43 [11791174] J Immunol. 2002 Mar 15;168(6):2963-9 [11884468] J Clin Invest. 2002 May;109(9):1125-31 [11994399] Alcohol. 2002 May;27(1):63-8 [12062639] Nat Rev Immunol. 2005 Dec;5(12):953-64 [16322748] Hepatology. 2006 Feb;43(2 Suppl 1):S63-74 [16447273] Gut. 2006 Aug;55(8):1188-96 [16120756] Hepatology. 2006 Sep;44(3):521-6 [16941687] Aliment Pharmacol Ther. 2006 Oct 15;24(8):1151-61 [17014574] J Hepatol. 2006 Nov;45(5):717-24 [16879892] Hepatology. 2007 Mar;45(3):778-88 [17326204] Hepatology. 2007 Feb;45(2):486-94 [17256754] Gastroenterology. 2007 Mar;132(3):1117-26 [17383432] Am J Pathol. 2007 Jun;170(6):2149-58 [17525280] Hepatology. 2007 Jun;45(6):1366-74 [17476695] Alcohol. 2007 Jun;41(4):271-80 [17630087] Hepatology. 2007 Nov;46(5):1564-73 [17705264] Hepatology. 2007 Dec;46(6):2032-9 [18046720] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84 [12571365] Gastroenterology. 2003 Mar;124(3):778-90 [12612915] Hepatology. 2003 Jul;38(1):218-29 [12830005] J Clin Invest. 2003 Jul;112(1):91-100 [12840063] Gastroenterology. 2003 Jul;125(1):202-15 [12851884] Gastroenterology. 2003 Aug;125(2):532-43 [12891556] Exp Biol Med (Maywood). 2003 Sep;228(8):882-90 [12968059] J Clin Invest. 2003 Oct;112(7):989-98 [14523036] J Exp Med. 2003 Nov 17;198(10):1517-25 [14623907] J Biol Chem. 2002 Aug 9;277(32):28411-7 [12032149] J Biol Chem. 2002 Aug 9;277(32):29342-7 [12036955] Cytokine Growth Factor Rev. 2002 Aug-Oct;13(4-5):357-68 [12220549] Nat Med. 2004 Feb;10(2):168-74 [14716305] J Neurosci Res. 2004 Apr 15;76(2):265-76 [15048924] Hepatology. 2004 Jul;40(1):185-94 [15239102] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10422-7 [15240880] Hepatology. 2004 Aug;40(2):442-51 [15368449] Curr Pharm Des. 2004;10(23):2839-50 [15379672] Hepatology. 2004 Oct;40(4):933-41 [15382116] J Clin Invest. 1996 Oct 1;98(7):1575-84 [8833906] Immunity. 1999 Jan;10(1):39-49 [10023769] Gastroenterology. 1999 Oct;117(4):942-52 [10500078] Alcohol. 2004 Aug;34(1):59-65 [15670667] J Clin Invest. 2005 Apr;115(4):860-9 [15761498] Cell. 2005 Jul 1;121(7):977-90 [15989949] Hepatology. 2005 Sep;42(3):568-77 [16108051] J Hepatol. 2005 Oct;43(4):687-95 [16098628] Mol Cell Biol. 2001 Mar;21(5):1621-32 [11238899] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1053/j.gastro.2008.01.016 ER - TY - JOUR T1 - The ratio of specific polychlorinated biphenyls as a surrogate biomarker of cytochrome P4501A2 activity: a pharmaco-metabonomic study in humans. AN - 70479081; 18398048 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Ye, Xibiao AU - Fitzgerald, Edward F AU - Gomez, Marta I AU - Lambert, George H AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 1013 EP - 1015 VL - 17 IS - 4 SN - 1055-9965, 1055-9965 KW - Biomarkers KW - 0 KW - Environmental Pollutants KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Cytochrome P-450 CYP1A2 KW - EC 1.14.14.1 KW - Index Medicus KW - Humans KW - Adult KW - Biomarkers -- blood KW - Male KW - Female KW - Cytochrome P-450 CYP1A2 -- drug effects KW - Environmental Pollutants -- pharmacology KW - Polychlorinated Biphenyls -- pharmacology KW - Polychlorinated Biphenyls -- blood KW - Cytochrome P-450 CYP1A2 -- metabolism KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70479081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=The+ratio+of+specific+polychlorinated+biphenyls+as+a+surrogate+biomarker+of+cytochrome+P4501A2+activity%3A+a+pharmaco-metabonomic+study+in+humans.&rft.au=Ye%2C+Xibiao%3BFitzgerald%2C+Edward+F%3BGomez%2C+Marta+I%3BLambert%2C+George+H%3BLongnecker%2C+Matthew+P&rft.aulast=Ye&rft.aufirst=Xibiao&rft.date=2008-04-01&rft.volume=17&rft.issue=4&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0040 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Clin Pharmacol Ther. 2000 Jan;38(1):1-9 [10667830] Biomed Mass Spectrom. 1979 Aug;6(8):350-5 [497361] IARC Sci Publ. 1999;(148):173-95 [10493258] BMC Cancer. 2007;7:123 [17615053] Environ Health Perspect. 2005 Oct;113(10):1318-24 [16203240] Nature. 2006 Apr 20;440(7087):1073-7 [16625200] Eur J Clin Pharmacol. 2007 Jun;63(6):537-46 [17370067] Environ Health Perspect. 2005 Mar;113(3):272-7 [15743714] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0040 ER - TY - JOUR T1 - Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis. AN - 70474766; 18267974 AB - Base excision repair (BER) provides relief from many DNA lesions. While BER enzymes have been characterized biochemically, BER functions within cells are much less understood, in part because replication bypass and double-strand break (DSB) repair can also impact resistance to base damage. To investigate BER in vivo, we examined the repair of methyl methanesulfonate (MMS) induced DNA damage in haploid G1 yeast cells, so that replication bypass and recombinational DSB repair cannot occur. Based on the heat-lability of MMS-induced base damage, an assay was developed that monitors secondary breaks in full-length yeast chromosomes where closely spaced breaks yield DSBs that are observed by pulsed-field gel electrophoresis. The assay detects damaged bases and abasic (AP) sites as heat-dependent breaks as well as intermediate heat-independent breaks that arise during BER. Using a circular chromosome, lesion frequency and repair kinetics could be easily determined. Monitoring BER in single and multiple glycosylase and AP-endonuclease mutants confirmed that Mag1 is the major enzyme that removes MMS-damaged bases. This approach provided direct physical evidence that Apn1 and Apn2 not only repair cellular base damage but also prevent break accumulation that can result from AP sites being channeled into other BER pathway(s). JF - Nucleic acids research AU - Ma, Wenjian AU - Resnick, Michael A AU - Gordenin, Dmitry A AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences (NIH, DHHS), Research Triangle Park, NC 27709, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 1836 EP - 1846 VL - 36 IS - 6 KW - Saccharomyces cerevisiae Proteins KW - 0 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Endodeoxyribonucleases KW - EC 3.1.- KW - Apn1 protein, S cerevisiae KW - EC 3.1.25.- KW - DNA Glycosylases KW - EC 3.2.2.- KW - MAG1 protein, S cerevisiae KW - EC 3.2.2.21 KW - APN2 protein, S cerevisiae KW - EC 4.2.99.18 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Hot Temperature KW - Methyl Methanesulfonate -- toxicity KW - G1 Phase -- genetics KW - Electrophoresis, Gel, Pulsed-Field KW - DNA Glycosylases -- physiology KW - Gene Deletion KW - Saccharomyces cerevisiae Proteins -- physiology KW - Saccharomyces cerevisiae -- genetics KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- physiology KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- genetics KW - DNA Repair KW - Saccharomyces cerevisiae Proteins -- genetics KW - Endodeoxyribonucleases -- genetics KW - Saccharomyces cerevisiae -- enzymology KW - DNA Breaks, Double-Stranded KW - Endodeoxyribonucleases -- physiology KW - Chromosomes, Fungal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70474766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Summary+of+chemically+induced+pulmonary+lesions+in+the+National+Toxicology+Program+%28NTP%29+toxicology+and+carcinogenesis+studies.&rft.au=Dixon%2C+Darlene%3BHerbert%2C+Ronald+A%3BKissling%2C+Grace+E%3BBrix%2C+Amy+E%3BMiller%2C+Rodney+A%3BMaronpot%2C+Robert+R&rft.aulast=Dixon&rft.aufirst=Darlene&rft.date=2008-04-01&rft.volume=36&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623308315360 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-08 N1 - Date created - 2008-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 2000 Apr;182(8):2104-12 [10735851] Mol Cell Biol. 2007 Oct;27(20):7198-205 [17698580] Chem Res Toxicol. 2000 Apr;13(4):257-61 [10775325] Mol Cell Biol. 2000 May;20(10):3522-8 [10779341] Nature. 2000 Jun 15;405(6788):807-10 [10866204] Bioessays. 2001 Mar;23(3):270-81 [11223884] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5122-7 [11309502] Prog Nucleic Acid Res Mol Biol. 2001;68:xvii-xxx [11554316] Mutat Res. 2001 Dec 19;487(3-4):137-47 [11738940] Proc Natl Acad Sci U S A. 2002 May 14;99(10):6860-5 [11983862] EMBO J. 2002 Jun 3;21(11):2833-41 [12032096] Mol Cancer Res. 2002 Dec;1(2):103-12 [12496357] DNA Repair (Amst). 2003 Jan 2;2(1):27-48 [12509266] Radiat Res. 2003 Apr;159(4):502-10 [12643795] J Biol Chem. 2003 Aug 15;278(33):31434-43 [12783866] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14994-9 [14630945] DNA Repair (Amst). 2004 Jan 5;3(1):1-12 [14697754] DNA Repair (Amst). 2004 Jan 5;3(1):51-9 [14697759] Biochimie. 2003 Nov;85(11):1053-71 [14726013] DNA Repair (Amst). 2004 Nov 2;3(11):1389-407 [15380096] Mol Cell. 2004 Oct 8;16(1):117-25 [15469827] Nature. 2004 Oct 21;431(7011):1011-7 [15496928] Biochemistry. 1972 Sep 12;11(19):3618-23 [4559796] Biochimie. 1982 Aug-Sep;64(8-9):637-41 [6814512] Mutat Res. 1985 Jun-Jul;150(1-2):77-84 [4000169] Genetics. 1989 Dec;123(4):695-713 [2693206] Proc Natl Acad Sci U S A. 1990 Jun;87(11):4193-7 [1693433] Mutat Res. 1990 Jul;231(1):11-30 [2195323] EMBO J. 1990 Dec;9(13):4569-75 [2265620] Biochemistry. 1997 May 20;36(20):6100-6 [9166780] Biochem J. 1997 Jul 1;325 ( Pt 1):1-16 [9224623] Curr Genet. 1998 Feb;33(2):92-9 [9506896] Genes Dev. 1998 Oct 1;12(19):3137-43 [9765213] Nucleic Acids Res. 1999 Feb 15;27(4):956-62 [9927726] Mol Cell Biol. 1999 Mar;19(3):1800-9 [10022867] Nucleic Acids Res. 2005;33(12):3799-811 [16009812] Chromosome Res. 2006;14(1):27-37 [16506094] Methods Enzymol. 2006;409:195-213 [16793403] Methods Enzymol. 2006;409:329-45 [16793410] Chem Res Toxicol. 2006 Dec;19(12):1580-94 [17173371] DNA Repair (Amst). 2007 Apr 1;6(4):429-42 [17112791] DNA Repair (Amst). 2007 Apr 1;6(4):530-43 [17113833] Mutat Res. 2000 Apr;462(2-3):129-35 [10767624] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkm1148 ER - TY - JOUR T1 - Ethyl pyruvate decreased early nuclear factor-kappaB levels but worsened survival in lipopolysaccharide-challenged mice. AN - 70452402; 18176313 AB - Ethyl pyruvate (EP) treatment inhibits nuclear factor (NF)-kappaB-mediated inflammation and has been considered for sepsis. However, NF-kappaB is also protective, and its inhibition may have adverse effects. We studied EP in lipopolysaccharide-challenged mice and systematically analyzed its efficacy in published sepsis models. After lipopolysaccharide, compared with placebo (n = 68), each of six doses of EP (0.01-100 mg/kg, n = 204) increased the hazards ratio of death. Although these increases were individually not significant (p = .13 to .37), when combined, they were (log mean +/- SEM, 0.26 +/- 0.13; p = .01). At 3 and 9 hrs after challenge, lipopolysaccharide increased lung NF-kappaB and 12 serum cytokines (p < or = .05 vs. phosphate-buffered saline challenge, except for interleukin-4 at 9 hrs). With lipopolysaccharide, although EP (100 mg/kg) decreased NF-kappaB and 11 of 12 cytokines at 3 hrs, it increased NF-kappaB and 11 of 12 cytokines at 9 hrs in patterns that differed (p < or = .05) across time points. In 14 published comparisons, EP's effects on the odds ratio of death varied (I2 = 85% [95% confidence interval, 74-91%], p < .0001), decreasing it significantly in five of the studies but not the other nine. In three of the latter, it increased time to death. Although EP has had promising effects in some preclinical sepsis models, it has not in others, and in the present model, it worsened outcome. Based on the complex role NF-kappaB has regulating both maladaptive and protective host responses, further defining factors that influence EP's effects is important if this agent is considered for patients with or at risk of sepsis. JF - Critical care medicine AU - Su, Junwu AU - Li, Xuemei AU - Cui, Xizhong AU - Li, Yan AU - Fitz, Yvonne AU - Hsu, Lewis AU - Mani, Haresh AU - Quezado, Martha AU - Eichacker, Peter Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 1059 EP - 1067 VL - 36 IS - 4 KW - Cytokines KW - 0 KW - Lipopolysaccharides KW - NF-kappa B KW - Pyruvates KW - lipopolysaccharide, Escherichia coli O111 B4 KW - ethyl pyruvate KW - 03O98E01OB KW - Abridged Index Medicus KW - Index Medicus KW - Cytokines -- blood KW - Animals KW - Treatment Failure KW - Kidney -- pathology KW - Mice, Inbred C57BL KW - Lung -- drug effects KW - Kidney -- drug effects KW - Lipopolysaccharides -- toxicity KW - Mice KW - Lung -- pathology KW - Proportional Hazards Models KW - Sepsis -- pathology KW - Pyruvates -- pharmacology KW - Pyruvates -- therapeutic use KW - Sepsis -- drug therapy KW - NF-kappa B -- physiology KW - NF-kappa B -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70452402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+care+medicine&rft.atitle=Ethyl+pyruvate+decreased+early+nuclear+factor-kappaB+levels+but+worsened+survival+in+lipopolysaccharide-challenged+mice.&rft.au=Su%2C+Junwu%3BLi%2C+Xuemei%3BCui%2C+Xizhong%3BLi%2C+Yan%3BFitz%2C+Yvonne%3BHsu%2C+Lewis%3BMani%2C+Haresh%3BQuezado%2C+Martha%3BEichacker%2C+Peter+Q&rft.aulast=Su&rft.aufirst=Junwu&rft.date=2008-04-01&rft.volume=36&rft.issue=4&rft.spage=1059&rft.isbn=&rft.btitle=&rft.title=Critical+care+medicine&rft.issn=1530-0293&rft_id=info:doi/10.1097%2FCCM.0B013E318164403B LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-28 N1 - Date created - 2008-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Crit Care Med. 2008 Apr;36(4):1361-3 [18379268] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CCM.0B013E318164403B ER - TY - JOUR T1 - The epidemiology of acquired aplastic anemia. AN - 70452271; 18379007 JF - Haematologica AU - Young, Neal S AU - Kaufman, David W AD - Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 489 EP - 492 VL - 93 IS - 4 KW - Immunosuppressive Agents KW - 0 KW - Pesticides KW - Benzene KW - J64922108F KW - Index Medicus KW - Humans KW - Autoimmune Diseases -- etiology KW - Autoimmune Diseases -- drug therapy KW - Benzene -- toxicity KW - Autoimmune Diseases -- epidemiology KW - Incidence KW - Thailand -- epidemiology KW - Europe -- epidemiology KW - Spain -- epidemiology KW - Immunosuppressive Agents -- therapeutic use KW - Pesticides -- toxicity KW - Anemia, Aplastic -- epidemiology KW - Anemia, Aplastic -- etiology KW - Anemia, Aplastic -- immunology KW - Anemia, Aplastic -- physiopathology KW - Anemia, Aplastic -- drug therapy KW - Anemia, Aplastic -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70452271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Haematologica&rft.atitle=The+epidemiology+of+acquired+aplastic+anemia.&rft.au=Young%2C+Neal+S%3BKaufman%2C+David+W&rft.aulast=Young&rft.aufirst=Neal&rft.date=2008-04-01&rft.volume=93&rft.issue=4&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Haematologica&rft.issn=1592-8721&rft_id=info:doi/10.3324%2Fhaematol.12855 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-02 N1 - Date created - 2008-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Haematologica. 2008 Apr;93(4):518-23 [18322256] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3324/haematol.12855 ER - TY - JOUR T1 - Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning. AN - 70450482; 18381458 AB - Aberrant methylation of CpG islands in gene promoters often represents an early clonal event in carcinogenesis. Accordingly, defining methylation profiles may be useful for developing marker panels for early detection or predicting the risk of cancer precursors. To identify specific genes frequently methylated in cervical cancer, we conducted methylation profiling of 20 primary human cervical cancers using NotI-based restriction landmark genomic scanning (RLGS). Of 2,172 RLGS fragments analyzed (average, 1,753 CpG islands per patient), 186 RLGS fragments were lost in at least one tumor and 40 were lost in three or more. Methylation was identified in 19 (95%) of 20 tumor samples compared with normal DNA. Bisulfite sequencing was conducted to confirm RLGS results. Of the confirmed markers frequently methylated, we developed Methylight assays for two corresponding genes, nucleolar protein 4 (NOL4), and lipoma HMGIC fusion partner-like protein 4 (LHFPL4), which were methylated in 85% and 55% of cancers, respectively. Using these assays, we further confirmed frequent CpG island methylation in the original cancers and in another independent series of 15 cervical cancers. We also showed methylation at a reduced frequency in a set of carefully reviewed cytology specimens demonstrating cells exfoliated from cancer precursor lesions. In summary, we identified, for the first time, NOL4 and LHFPL4 as novel methylation targets specific for cervical cancer. Inclusion of NOL4 and LHFPL4 in evaluating methylation panels for early detection, risk prediction, and etiologic research on cervical cancer is warranted. JF - Cancer research AU - Wang, Sophia S AU - Smiraglia, Dominic J AU - Wu, Yue-Zhong AU - Ghosh, Srimoyee AU - Rader, Janet S AU - Cho, Kathleen R AU - Bonfiglio, Thomas A AU - Nayar, Ritu AU - Plass, Christoph AU - Sherman, Mark E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852-7234, USA. wangso@mail.nih.gov Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 2489 EP - 2497 VL - 68 IS - 7 KW - Index Medicus KW - Genome, Human KW - Humans KW - CpG Islands KW - Female KW - DNA Methylation KW - Carcinoma, Squamous Cell -- genetics KW - Uterine Cervical Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70450482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Identification+of+novel+methylation+markers+in+cervical+cancer+using+restriction+landmark+genomic+scanning.&rft.au=Wang%2C+Sophia+S%3BSmiraglia%2C+Dominic+J%3BWu%2C+Yue-Zhong%3BGhosh%2C+Srimoyee%3BRader%2C+Janet+S%3BCho%2C+Kathleen+R%3BBonfiglio%2C+Thomas+A%3BNayar%2C+Ritu%3BPlass%2C+Christoph%3BSherman%2C+Mark+E&rft.aulast=Wang&rft.aufirst=Sophia&rft.date=2008-04-01&rft.volume=68&rft.issue=7&rft.spage=2489&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-07-3194 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-25 N1 - Date created - 2008-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-07-3194 ER - TY - JOUR T1 - Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells. AN - 70449082; 18283040 AB - Prostate stromal and epithelial cell communication is important in prostate functioning and cancer development. Primary human stromal cells from normal prostate stromal cells (PRSC) maintain a smooth muscle phenotype, whereas those from prostate cancer (6S) display reactive and fibroblastic characteristics. Dihydrotestosterone (DHT) stimulates insulin-like growth factor-I (IGF-I) production by 6S but not PSRC cells. Effects of reactive versus normal stroma on normal human prostate epithelial (NPE or PREC) cells are poorly understood. We co-cultured NPE plus 6S or PRSC cells to compare influences of different stromal cells on normal epithelium. Because NPE and PREC cells lose androgen receptor (AR) expression in culture, DHT effects must be modulated by associated stromal cells. When treated with camptothecin (CM), NPE cells, alone and in stromal co-cultures, displayed a dose-dependent increase in DNA fragmentation. NPE/6S co-cultures exhibited reduced CM-induced cell death with exposure to DHT, whereas NPE/PRSC co-cultures exhibited CM-induced cell death regardless of DHT treatment. DHT blocked CM-induced, IGF-I-mediated, NPE death in co-cultured NPE/6S cells without, but not with, added anti-IGF-I and anti-IGF-R antibodies. Lycopene consumption is inversely related to human prostate cancer risk and inhibits IGF-I and androgen signaling in rat prostate cancer. In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I's effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3. This study expands the understanding of the preventive mechanisms of lycopene in prostate cancer. JF - Carcinogenesis AU - Liu, Xunxian AU - Allen, Jeffrey D AU - Arnold, Julia T AU - Blackman, Marc R AD - Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 816 EP - 823 VL - 29 IS - 4 KW - Carotenoids KW - 36-88-4 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - lycopene KW - SB0N2N0WV6 KW - Index Medicus KW - Coculture Techniques KW - Tumor Cells, Cultured KW - Cells, Cultured KW - Humans KW - Adult KW - Prostatic Neoplasms KW - Male KW - Insulin-Like Growth Factor I -- physiology KW - Epithelial Cells -- physiology KW - Epithelial Cells -- cytology KW - Insulin-Like Growth Factor I -- drug effects KW - Insulin-Like Growth Factor I -- antagonists & inhibitors KW - Epithelial Cells -- drug effects KW - Stromal Cells -- drug effects KW - Stromal Cells -- physiology KW - Signal Transduction -- drug effects KW - Cell Division -- drug effects KW - Carotenoids -- pharmacology KW - Stromal Cells -- cytology KW - Prostate -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70449082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Lycopene+inhibits+IGF-I+signal+transduction+and+growth+in+normal+prostate+epithelial+cells+by+decreasing+DHT-modulated+IGF-I+production+in+co-cultured+reactive+stromal+cells.&rft.au=Liu%2C+Xunxian%3BAllen%2C+Jeffrey+D%3BArnold%2C+Julia+T%3BBlackman%2C+Marc+R&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2008-04-01&rft.volume=29&rft.issue=4&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-28 N1 - Date created - 2008-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn011 ER - TY - JOUR T1 - Association of analgesic use with prevalence of albuminuria and reduced GFR in US adults. AN - 70448439; 18371533 AB - Prolonged analgesic consumption may adversely affect kidney function. The relation of long-term analgesic use to markers of decreased kidney function has not been investigated in the general population. Cross-sectional analysis. National Health and Nutrition Examination Survey conducted in 1999-2002. Noninstitutionalized residents at least 20 years old (n = 8,057, representing 177.8 million adults). Ever intake of an analgesic every day for at least a month defined habitual analgesic use, classified by product (aspirin, acetaminophen, ibuprofen, and selected prescription drugs) and years of use (5 years). Albuminuria in random urine (albumin-creatinine ratio >or= 30 mg/g; n = 1,088) and reduced estimated glomerular filtration rate (eGFR; <60 mL/min/1.73 m(2), n = 852) using the Modification of Diet in Renal Disease Study equation and the composite of either. Age-standardized prevalence in habitual analgesic users and non-habitual analgesic users and multivariable-adjusted odds ratios (ORs). In US adults, 23.7% (95% confidence interval [CI], 21.7 to 25.6) reported habitual analgesic use. Multivariable-adjusted ORs for reduced eGFR prevalence in adults with habitual analgesic use of acetaminophen only, ibuprofen only, and aspirin only were 1.03 (95% CI, 0.6 to 1.7), 1.21 (95% CI, 0.7 to 2.1), and 0.95 (95% CI, 0.7 to 1.2) compared with non-habitual analgesic use, respectively. Corresponding ORs for prevalent albuminuria were 0.93 (95% CI, 0.7 to 1.3), 0.65 (95% CI, 0.4 to 1.2), and 0.86 (95% CI, 0.6 to 1.2). Association measures had intermediate levels for the composite marker of decreased kidney function and were not significant. No association between prevalent outcomes and habitual analgesic exposure duration of 5 years or longer or multiple product habitual analgesic consumption was observed. Reliability of self-reported analgesic use behavior was not assessed. Habitual analgesic use of single or multiple products was not associated with increased prevalence of albuminuria or reduced eGFR. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Agodoa, Lawrence Y AU - Francis, Mildred E AU - Eggers, Paul W AD - Division of Kidney, Urologic, and Hematologic Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892-5458, USA. agodoal@extra.niddk.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 573 EP - 583 VL - 51 IS - 4 KW - Analgesics KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Aspirin KW - R16CO5Y76E KW - Ibuprofen KW - WK2XYI10QM KW - Index Medicus KW - United States KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Prevalence KW - Aspirin -- adverse effects KW - Ibuprofen -- adverse effects KW - Glomerular Filtration Rate -- drug effects KW - Acetaminophen -- adverse effects KW - Kidney Diseases -- epidemiology KW - Albuminuria -- epidemiology KW - Albuminuria -- chemically induced KW - Analgesics -- adverse effects KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70448439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Association+of+analgesic+use+with+prevalence+of+albuminuria+and+reduced+GFR+in+US+adults.&rft.au=Agodoa%2C+Lawrence+Y%3BFrancis%2C+Mildred+E%3BEggers%2C+Paul+W&rft.aulast=Agodoa&rft.aufirst=Lawrence&rft.date=2008-04-01&rft.volume=51&rft.issue=4&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=1523-6838&rft_id=info:doi/10.1053%2Fj.ajkd.2007.12.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-28 N1 - Date created - 2008-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1053/j.ajkd.2007.12.014 ER - TY - JOUR T1 - Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives. AN - 70444084; 18287222 AB - Factors that mediate increases in salt sensitivity of blood pressure with age remain to be clarified. The present study investigated 1) the effects of high-NaCl intake on two Na pump inhibitors, endogenous ouabain (EO) and marinobufagenin (MBG), in middle-aged and older normotensive Caucasian women; and 2) whether individual differences in EO and MBG are linked to variations in sodium excretion or salt sensitivity. A change from 6 days of a lower (0.7 mmol.kg(-1).day(-1))- to 6 days of a higher (4 mmol.kg(-1).day(-1))-NaCl diet elicited a sustained increase in MBG excretion that directly correlated with an increase in the fractional Na excretion and was inversely related to age and to an age-dependent increase in salt sensitivity. In contrast, EO excretion increased only transiently in response to NaCl loading and did not vary with age or correlate with fractional Na excretion or salt sensitivity. A positive correlation of both plasma and urine levels of EO and MBG during salt loading may indicate a casual link between two Na pump inhibitors in response to NaCl loading, as observed in animal models. A linear mixed-effects model demonstrated that age, dietary NaCl, renal MBG excretion, and body mass index were each independently associated with systolic blood pressure. Thus, a sustained increase in MBG in response to acutely elevated dietary NaCl is inversely linked to salt sensitivity in normotensive middle-aged and older women, and a relative failure of MBG elaboration by these older persons may be involved in the increased salt sensitivity with advancing age. JF - American journal of physiology. Regulatory, integrative and comparative physiology AU - Anderson, David E AU - Fedorova, Olga V AU - Morrell, Christopher H AU - Longo, Dan L AU - Kashkin, Vladimir A AU - Metzler, Jessica D AU - Bagrov, Alexei Y AU - Lakatta, Edward G AD - Laboratory on Cardiovascular Science, National Institute on Aging, Intramural Research Program, Gerontology Research Center, Baltimore, MD 21224-6825, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - R1248 EP - R1254 VL - 294 IS - 4 SN - 0363-6119, 0363-6119 KW - Bufanolides KW - 0 KW - Enzyme Inhibitors KW - Sodium Chloride, Dietary KW - marinobufagenin KW - 470-42-8 KW - Ouabain KW - 5ACL011P69 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Index Medicus KW - Age Factors KW - Hypertension -- physiopathology KW - Humans KW - Linear Models KW - Aged KW - Body Mass Index KW - Models, Biological KW - Adult KW - Natriuresis KW - Hypertension -- etiology KW - Middle Aged KW - Up-Regulation KW - Time Factors KW - Systole KW - Female KW - Hypertension -- metabolism KW - Aging -- metabolism KW - Ouabain -- metabolism KW - Blood Pressure KW - Enzyme Inhibitors -- urine KW - Bufanolides -- metabolism KW - Sodium-Potassium-Exchanging ATPase -- antagonists & inhibitors KW - Sodium-Potassium-Exchanging ATPase -- metabolism KW - Sodium Chloride, Dietary -- adverse effects KW - Ouabain -- blood KW - Sodium Chloride, Dietary -- metabolism KW - Bufanolides -- blood KW - Ouabain -- urine KW - Enzyme Inhibitors -- blood KW - Enzyme Inhibitors -- metabolism KW - Sodium Chloride, Dietary -- administration & dosage KW - Bufanolides -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70444084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Regulatory%2C+integrative+and+comparative+physiology&rft.atitle=Endogenous+sodium+pump+inhibitors+and+age-associated+increases+in+salt+sensitivity+of+blood+pressure+in+normotensives.&rft.au=Anderson%2C+David+E%3BFedorova%2C+Olga+V%3BMorrell%2C+Christopher+H%3BLongo%2C+Dan+L%3BKashkin%2C+Vladimir+A%3BMetzler%2C+Jessica+D%3BBagrov%2C+Alexei+Y%3BLakatta%2C+Edward+G&rft.aulast=Anderson&rft.aufirst=David&rft.date=2008-04-01&rft.volume=294&rft.issue=4&rft.spage=R1248&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Regulatory%2C+integrative+and+comparative+physiology&rft.issn=03636119&rft_id=info:doi/10.1152%2Fajpregu.00782.2007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-04-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Circulation. 2000 Dec 12;102(24):3009-14 [11113054] Front Biosci. 2005;10:2250-6 [15970491] Hypertension. 2001 Feb;37(2 Pt 2):462-6 [11230319] Am J Hypertens. 2001 Aug;14(8 Pt 1):761-7 [11497191] Hypertension. 2002 Feb;39(2):298-302 [11847201] Circulation. 2002 Mar 5;105(9):1122-7 [11877366] Curr Opin Cardiol. 2002 Jul;17(4):360-7 [12151870] Hypertension. 2004 Jul;44(1):35-41 [15173128] Am J Hypertens. 2004 Oct;17(10):994-1001 [15485766] J Physiol. 1969 Feb;200(2):431-58 [5764407] Ann Intern Med. 1976 May;84(5):567-9 [1275359] Am J Physiol. 1977 May;232(5):C165-73 [324293] Life Sci. 1979 Jun 4;24(23):2105-17 [384124] Physiol Rev. 1985 Jul;65(3):658-759 [2989958] Hypertension. 1986 Jun;8(6 Pt 2):II127-34 [3522418] Circulation. 1988 Jan;77(1):53-61 [3257173] J Am Geriatr Soc. 1989 Aug;37(8):780-90 [2666486] Hypertension. 1991 Jul;18(1):67-71 [1860713] Pharmacol Rev. 1992 Sep;44(3):377-99 [1332083] Hypertension. 1995 Nov;26(5):781-8 [7591018] J Hypertens. 2005 Aug;23(8):1515-23 [16003178] Am J Nephrol. 2005 Sep-Oct;25(5):520-8 [16179779] Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R529-35 [16467500] Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R553-9 [16467503] Hypertension. 2006 Dec;48(6):1160-8 [17043158] Pharmacogenomics. 2007 May;8(5):465-72 [17465710] Am J Physiol Cell Physiol. 2007 Aug;293(2):C509-36 [17494630] Curr Opin Nephrol Hypertens. 1996 May;5(3):205-8 [8737853] Hypertension. 1997 Oct;30(4):886-96 [9336389] Clin Exp Hypertens. 1998 Jul-Aug;20(5-6):499-508 [9682906] Chin Med Sci J. 2004 Dec;19(4):248-51 [15669180] J Hypertens. 2005 Apr;23(4):835-42 [15775789] N Engl J Med. 2001 Jan 4;344(1):3-10 [11136953] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1152/ajpregu.00782.2007 ER - TY - JOUR T1 - Two independent forms of endocytosis maintain embryonic cell surface homeostasis during early development. AN - 70440331; 18281031 AB - Eukaryotic cells have multiple forms of endocytosis which maintain cell surface homeostasis. One explanation for this apparent redundancy is to allow independent retrieval of surface membranes derived from different types of vesicles. Consistent with this hypothesis we find that sea urchin eggs have at least two types of compensatory endocytosis. One is associated with retrieving cortical vesicle membranes, and formed large endosomes by a mechanism that was inhibited by agatoxin, cadmium, staurosporine and FK506. The second type is thought to compensate for constitutive exocytosis, and formed small endosomes using a mechanism that was insensitive to the above mentioned reagents, but was inhibited by phenylarsine oxide (PAO), and by microinjection of mRNA encoding Src kinase. Both mechanisms could act concurrently, and account for all of the endocytosis occurring during early development. Inhibition of either form did not trigger compensation by the other form, and phorbol ester treatment rescued the endocytotic activity blocked by agatoxin, but not the retrieval blocked by PAO. JF - Developmental biology AU - Covian-Nares, J Fernando AU - Smith, Robert M AU - Vogel, Steven S AD - Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 135 EP - 148 VL - 316 IS - 1 KW - Agatoxins KW - 0 KW - Arsenicals KW - FM1 43 KW - Fluorescent Dyes KW - Pyridinium Compounds KW - Quaternary Ammonium Compounds KW - RNA, Messenger KW - Spider Venoms KW - omega-agatoxin-Aa4b KW - oxophenylarsine KW - 0HUR2WY345 KW - src-Family Kinases KW - EC 2.7.10.2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Quaternary Ammonium Compounds -- metabolism KW - Fluorescent Dyes -- analysis KW - Animals KW - Embryo, Nonmammalian -- ultrastructure KW - Quaternary Ammonium Compounds -- analysis KW - Fluorescent Dyes -- metabolism KW - Strongylocentrotus purpuratus -- drug effects KW - Embryo, Nonmammalian -- physiology KW - Cell Division -- drug effects KW - Exocytosis KW - Arsenicals -- pharmacology KW - Microinjections KW - RNA, Messenger -- genetics KW - src-Family Kinases -- genetics KW - Endosomes -- physiology KW - Ovum -- physiology KW - RNA, Messenger -- metabolism KW - Pyridinium Compounds -- metabolism KW - Strongylocentrotus purpuratus -- embryology KW - src-Family Kinases -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Pyridinium Compounds -- analysis KW - Spider Venoms -- pharmacology KW - Ovum -- ultrastructure KW - Endocytosis -- drug effects KW - Embryonic Development -- drug effects KW - Cell Membrane -- physiology KW - Homeostasis -- drug effects KW - Embryonic Development -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70440331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+biology&rft.atitle=Two+independent+forms+of+endocytosis+maintain+embryonic+cell+surface+homeostasis+during+early+development.&rft.au=Covian-Nares%2C+J+Fernando%3BSmith%2C+Robert+M%3BVogel%2C+Steven+S&rft.aulast=Covian-Nares&rft.aufirst=J&rft.date=2008-04-01&rft.volume=316&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Developmental+biology&rft.issn=1095-564X&rft_id=info:doi/10.1016%2Fj.ydbio.2008.01.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-14 N1 - Date created - 2008-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 2000 Feb 21;148(4):755-67 [10684256] Dev Biol. 1993 May;157(1):157-69 [8482408] Traffic. 2000 Dec;1(12):921-6 [11208081] Traffic. 2001 Sep;2(9):654-67 [11555419] J Biol Chem. 2001 Nov 23;276(47):43663-7 [11546805] J Physiol. 2001 Dec 15;537(Pt 3):871-85 [11744761] Nat Biotechnol. 2002 Jan;20(1):87-90 [11753368] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3633-8 [11891298] Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6358-63 [11959911] Sci STKE. 2002 Dec 10;2002(162):pe52 [12476002] Nat Rev Mol Cell Biol. 2003 Feb;4(2):127-39 [12563290] Dev Biol. 2003 Apr 15;256(2):367-78 [12679109] Dev Biol. 2003 Jul 1;259(1):62-70 [12812788] J Physiol. 2003 Dec 15;553(Pt 3):707-17 [14500763] J Cell Biol. 1976 Oct;71(1):35-48 [988032] Nature. 1993 Sep 9;365(6442):163-6 [8371759] Science. 1994 Aug 12;265(5174):970-3 [8052858] Nature. 1995 Jun 15;375(6532):577-81 [7540725] Nature. 1995 Sep 7;377(6544):75-9 [7544874] J Cell Sci. 1995 Jun;108 ( Pt 6):2293-300 [7673349] Curr Top Dev Biol. 1995;30:63-101 [7555050] J Cell Biol. 1995 Dec;131(5):1183-92 [8522582] Biochimie. 1995;77(4):279-87 [8589058] Curr Opin Neurobiol. 1996 Jun;6(3):365-71 [8794083] J Cell Biol. 1997 Nov 17;139(4):885-94 [9362507] J Biol Chem. 1997 Dec 5;272(49):30984-92 [9388246] J Physiol. 1998 Feb 1;506 ( Pt 3):591-608 [9503324] Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5019-24 [10220411] J Cell Sci. 1999 Aug;112 ( Pt 15):2549-57 [10393811] Mol Biol Cell. 1999 Aug;10(8):2735-43 [10436024] J Neurosci. 2005 Aug 10;25(32):7324-32 [16093382] Dev Cell. 2005 Dec;9(6):781-90 [16326390] Dev Cell. 2006 Jan;10(1):137-50 [16399085] Traffic. 2006 Mar;7(3):239-47 [16497219] Biochem J. 2006 Oct 1;399(1):111-9 [16784416] Dev Biol. 1977 Jul 1;58(1):185-96 [326602] Dev Biol. 1978 Nov;67(1):243-8 [720756] Dev Biol. 1983 Oct;99(2):456-72 [6413283] Annu Rev Physiol. 1986;48:191-200 [2423022] Cell Differ. 1987 Mar;20(2-3):137-46 [3568134] Endocrinology. 1989 Nov;125(5):2656-63 [2551660] J Biol Chem. 1991 Feb 15;266(5):2783-8 [1993657] Science. 1992 Jan 10;255(5041):200-3 [1553547] Curr Biol. 2000 Oct 19;10(20):R760-70 [11069103] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ydbio.2008.01.017 ER - TY - JOUR T1 - Update on azole antifungals. AN - 70438453; 18366001 AB - This is a comprehensive, clinically oriented review of the four commercially available triazoles: fluconazole, itraconazole, voriconazole, and posaconazole. Emphasis is placed in pharmacology, drug interactions, adverse events, antifungal activity, and the evolving perspective of their clinical use. Key clinical trials are briefly discussed, and specific drug indications summarized. Fluconazole remains a valuable low-cost choice for the treatment of various fungal infections, including candidiasis and cryptococcosis. It has relatively few drug interactions and is safe but lacks activity against filamentous fungi. The use of itraconazole is historically plagued by erratic bioavailability of the oral capsule, improved with the oral solution. Drug interactions are numerous. Itraconazole exhibits significant activity against Aspergillus and the endemic fungi. Voriconazole has revolutionized the treatment of aspergillosis in severely immunocompromised patients, but its use is compromised by complicated pharmacokinetics, notable drug interactions, and relatively significant adverse events. Finally, posaconazole is the last addition to the azole armamentarium with extended antifungal spectrum, significant activity against the zygomycetes, and, apparently, optimal safety profile. Posaconazole has a significant role for the prophylaxis of invasive fungal infections in severely immunocompromised patients. Multiple daily dosing, a need for fatty foods for absorption, and absence of an intravenous formulation restrict its use to selected populations. JF - Seminars in respiratory and critical care medicine AU - Zonios, Dimitrios I AU - Bennett, John E AD - Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 198 EP - 210 VL - 29 IS - 2 SN - 1069-3424, 1069-3424 KW - Antifungal Agents KW - 0 KW - Triazoles KW - Index Medicus KW - Drug Interactions KW - Humans KW - Clinical Trials as Topic KW - Biological Availability KW - Antifungal Agents -- pharmacokinetics KW - Antifungal Agents -- pharmacology KW - Mycoses -- drug therapy KW - Triazoles -- therapeutic use KW - Triazoles -- pharmacology KW - Triazoles -- pharmacokinetics KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70438453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+respiratory+and+critical+care+medicine&rft.atitle=Update+on+azole+antifungals.&rft.au=Zonios%2C+Dimitrios+I%3BBennett%2C+John+E&rft.aulast=Zonios&rft.aufirst=Dimitrios&rft.date=2008-04-01&rft.volume=29&rft.issue=2&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Seminars+in+respiratory+and+critical+care+medicine&rft.issn=10693424&rft_id=info:doi/10.1055%2Fs-2008-1063858 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-17 N1 - Date created - 2008-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-2008-1063858 ER - TY - JOUR T1 - Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms. AN - 70434316; 18218858 AB - Regulation of mRNA stability by p38 MAPK has been linked to adenosine-uridine-rich elements (AURE) within the 3'-untranslated region (3'UTR) of mRNA. Using microarrays, we previously found that AURE-containing mRNA is over-represented among transcripts up-regulated by NO(*), an activator of p38 MAPK. Here, we investigated NO(*)-induced mRNA stabilization of specific AURE-containing genes to determine the sequence specificity and protein-binding interactions associated with this effect. IL-8, TNF-alpha, and p21/Waf1 3'UTRs were inserted into a luciferase (LUC) reporter gene system and found to decrease LUC activity and mRNA half-life in transfected THP-1 cells. The inhibitory effect of these 3'UTRs on LUC expression inversely correlated with the number of AUUUA motifs. Sequence truncation of the IL-8 3'UTR revealed that two segments, one with AURE sites and another without, contributed to mRNA destabilization. NO(*) activation of p38 MAPK increased LUC activity and mRNA half-life for reporter constructs that contained either of these IL-8 3'UTR segments. AURE-dependent and -independent NO(*) effects were blocked by p38 MAPK inhibition, and AURE-dependent effects were also blocked by site-directed mutagenesis of AUUUA sites. Two proteins, HuR and heterogeneous nuclear ribonucleoprotein A0, were identified, which bound to the AURE-containing region of exogenous and endogenous IL-8 mRNA in a NO(*)-p38 MAPK-dependent manner. These results demonstrate that NO(*)-p38 MAPK signaling can stabilize mRNA via AURE-dependent and -independent mechanisms. JF - Journal of leukocyte biology AU - Wang, Shuibang AU - Zhang, Jianhua AU - Zhang, Yi AU - Kern, Steven AU - Danner, Robert L AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 982 EP - 990 VL - 83 IS - 4 SN - 0741-5400, 0741-5400 KW - 3' Untranslated Regions KW - 0 KW - DNA Primers KW - RNA, Messenger KW - Nitric Oxide KW - 31C4KY9ESH KW - Luciferases KW - EC 1.13.12.- KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Adenosine KW - K72T3FS567 KW - Uridine KW - WHI7HQ7H85 KW - Index Medicus KW - Uridine -- physiology KW - Adenosine -- physiology KW - Humans KW - Genes, Reporter KW - Reverse Transcriptase Polymerase Chain Reaction KW - Plasmids KW - Luciferases -- genetics KW - Cell Line KW - Monocytes -- physiology KW - p38 Mitogen-Activated Protein Kinases -- physiology KW - Nitric Oxide -- physiology KW - RNA, Messenger -- genetics KW - 3' Untranslated Regions -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70434316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Nitric+oxide-p38+MAPK+signaling+stabilizes+mRNA+through+AU-rich+element-dependent+and+-independent+mechanisms.&rft.au=Wang%2C+Shuibang%3BZhang%2C+Jianhua%3BZhang%2C+Yi%3BKern%2C+Steven%3BDanner%2C+Robert+L&rft.aulast=Wang&rft.aufirst=Shuibang&rft.date=2008-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Islet+and+Beta+Cell+Development+and+Transplantation+%28Z4%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-04 N1 - Date created - 2008-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1189/jlb.0907641 ER - TY - JOUR T1 - Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma. AN - 70425180; 18160665 AB - The activated B cell-like (ABC) subgroup of diffuse large B-cell lymphoma (DLBCL) is characterized by constitutive activation of the nuclear factor-kappaB (NF-kappaB) pathway. In this study, we showed that the NF-kappaB pathway induced the expression of the cytokines interleukin (IL)-6 and IL-10 in ABC DLBCL cell lines, which also have high levels of total and phosphorylated signal transducer and activator of transcription (STAT) 3 protein, suggesting autocrine signaling. Using RNA interference for STAT3, we defined a gene expression signature of IL-6 and IL-10 signaling through STAT3. Based on this signature, we constructed a molecular predictor of STAT3 signaling that defined a subset of ABC DLBCL tumors with high expression of STAT3, IL-6, and/or IL-10 and their downstream targets. Although the STAT3-high and STAT3-low subsets had equivalent expression of genes that distinguish ABC DLBCL from germinal center B cell-like DLBCL, STAT3-high ABC DLBCLs had higher expression of signatures that reflected NF-kappaB activity, proliferation, and glycolysis. A small-molecule inhibitor of Janus kinase signaling, which blocked STAT3 signature expression, was toxic only for ABC DLBCL lines and synergized with an inhibitor of NF-kappaB signaling. These findings suggest that the biological interplay between the STAT3 and NF-kappaB pathways may be exploited for the treatments of a subset of ABC DLBCLs. JF - Blood AU - Lam, Lloyd T AU - Wright, George AU - Davis, R Eric AU - Lenz, Georg AU - Farinha, Pedro AU - Dang, Lenny AU - Chan, John W AU - Rosenwald, Andreas AU - Gascoyne, Randy D AU - Staudt, Louis M AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 3701 EP - 3713 VL - 111 IS - 7 SN - 0006-4971, 0006-4971 KW - IL10 protein, human KW - 0 KW - IL6 protein, human KW - Interleukin-6 KW - NF-kappa B KW - Protein Kinase Inhibitors KW - STAT3 Transcription Factor KW - STAT3 protein, human KW - Interleukin-10 KW - 130068-27-8 KW - Janus Kinases KW - EC 2.7.10.2 KW - Abridged Index Medicus KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Autocrine Communication -- genetics KW - Protein Kinase Inhibitors -- pharmacology KW - Janus Kinases -- metabolism KW - Humans KW - Gene Expression Regulation, Leukemic -- genetics KW - Autocrine Communication -- drug effects KW - Cell Line, Tumor KW - Gene Expression Regulation, Leukemic -- drug effects KW - Janus Kinases -- antagonists & inhibitors KW - Glycolysis -- drug effects KW - Protein Kinase Inhibitors -- therapeutic use KW - Janus Kinases -- genetics KW - Signal Transduction -- drug effects KW - Interleukin-6 -- genetics KW - Signal Transduction -- genetics KW - Interleukin-10 -- biosynthesis KW - Interleukin-10 -- genetics KW - Interleukin-6 -- biosynthesis KW - RNA Interference KW - Glycolysis -- genetics KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - STAT3 Transcription Factor -- genetics KW - STAT3 Transcription Factor -- metabolism KW - Lymphoma, Large B-Cell, Diffuse -- metabolism KW - Lymphoma, Large B-Cell, Diffuse -- genetics KW - NF-kappa B -- genetics KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70425180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Cooperative+signaling+through+the+signal+transducer+and+activator+of+transcription+3+and+nuclear+factor-%7Bkappa%7DB+pathways+in+subtypes+of+diffuse+large+B-cell+lymphoma.&rft.au=Lam%2C+Lloyd+T%3BWright%2C+George%3BDavis%2C+R+Eric%3BLenz%2C+Georg%3BFarinha%2C+Pedro%3BDang%2C+Lenny%3BChan%2C+John+W%3BRosenwald%2C+Andreas%3BGascoyne%2C+Randy+D%3BStaudt%2C+Louis+M&rft.aulast=Lam&rft.aufirst=Lloyd&rft.date=2008-04-01&rft.volume=111&rft.issue=7&rft.spage=3701&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-03-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2000 May 15;19(21):2468-73 [10851045] Leukemia. 2007 Nov;21(11):2332-43 [17625604] Immunity. 2000 Aug;13(2):199-212 [10981963] Nat Genet. 2001 Jan;27(1):48-54 [11137997] Annu Rev Immunol. 2001;19:683-765 [11244051] Mol Cell Biol. 2001 Oct;21(19):6615-25 [11533249] Immunity. 2001 Sep;15(3):375-85 [11567628] Genome Biol. 2001;2(10):RESEARCH0041 [11597333] J Exp Med. 2001 Dec 17;194(12):1861-74 [11748286] Blood. 2002 Jan 15;99(2):618-26 [11781246] Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23 [11934592] Mol Biol Cell. 2002 Jun;13(6):1977-2000 [12058064] N Engl J Med. 2002 Jun 20;346(25):1937-47 [12075054] J Immunol. 2002 Sep 1;169(5):2253-63 [12193690] J Exp Med. 2002 Sep 16;196(6):743-52 [12235208] Blood. 2003 Feb 1;101(3):1164-71 [12393423] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9991-6 [12900505] J Cell Physiol. 2003 Nov;197(2):157-68 [14502555] Nat Med. 2004 Jan;10(1):48-54 [14702634] J Immunol. 2004 Jul 15;173(2):1158-65 [15240705] Science. 2004 Sep 3;305(5689):1466-70 [15353804] Adv Enzyme Regul. 1984;22:27-55 [6382953] Nature. 1986 Nov 6-12;324(6092):73-6 [3491322] Nature. 1988 Mar 3;332(6159):83-5 [3258060] Blood. 1989 Aug 1;74(2):798-804 [2787680] Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1890-3 [1371884] Blood. 1993 Dec 15;82(12):3712-20 [8260708] Cell. 1994 Apr 8;77(1):63-71 [7512451] Cancer Res. 1996 Dec 1;56(23):5499-505 [8968107] Nature. 2000 Feb 3;403(6769):503-11 [10676951] J Biol Chem. 2004 Jan 16;279(3):1768-76 [14593105] Leukemia. 2004 Mar;18(3):597-606 [14712288] Nature. 1997 Jun 26;387(6636):917-21 [9202125] J Leukoc Biol. 1998 Jun;63(6):665-8 [9620657] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] Clin Cancer Res. 2005 Jan 1;11(1):28-40 [15671525] Cancer Res. 2005 Feb 1;65(3):939-47 [15705894] Annu Rev Immunol. 2005;23:1-21 [15771564] Nature. 2005 Jun 2;435(7042):677-81 [15902208] Adv Immunol. 2005;87:163-208 [16102574] Eur J Cancer. 2005 Nov;41(16):2502-12 [16199153] Nat Clin Pract Oncol. 2005 Jun;2(6):315-24 [16264989] Nat Med. 2005 Dec;11(12):1314-21 [16288283] J Clin Oncol. 2006 Feb 20;24(6):961-8 [16418494] J Exp Med. 2006 Feb 20;203(2):311-7 [16492805] Immunol Rev. 2006 Apr;210:67-85 [16623765] Blood. 2006 May 15;107(10):4090-100 [16424392] Nature. 2006 May 4;441(7089):106-10 [16572121] Blood. 2006 Jun 1;107(11):4266-73 [16439676] Cancer Cell. 2006 Nov;10(5):375-88 [17097560] Cancer Cell. 2006 Nov;10(5):389-99 [17097561] Nat Rev Immunol. 2007 Jan;7(1):41-51 [17186030] J Biol Chem. 2007 Feb 9;282(6):3428-32 [17178722] J Immunol. 2007 Mar 1;178(5):2623-9 [17312100] Oncogene. 2007 Feb 26;26(9):1324-37 [17322918] Blood. 2007 Apr 1;109(7):2700-7 [17119127] Genes Dev. 2007 Jun 1;21(11):1396-408 [17510282] Cell. 2007 Jun 15;129(6):1065-79 [17574021] Nat Rev Cancer. 2007 Sep;7(9):673-83 [17721432] Oncogene. 2000 May 15;19(21):2474-88 [10851046] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer. AN - 70416454; 17985102 AB - Ultraviolet (UV)-induced skin cancers, including melanomas and basal/squamous cell carcinomas, occur more frequently in individuals with fair skin than in those with dark skin. Melanin plays an important role in protecting the skin against UV radiation and levels of melanin correlate inversely with amounts of DNA damage induced by UV in human skin of different racial/ethnic groups. The objectives of this study are to review recent progress in our understanding of mechanisms underlying differences in cancer incidence in skins of different colors, particularly between Black and White skin. More specifically, we review DNA damage and apoptosis in various types of skin before and after exposure to UV in our human study protocols using a single UV dose, either one minimal erythema dose (MED) or a similar low dose of 180-200 J/m2. Our data and other published reports indicate that several major mechanisms underlie the increased rates of photocarcinogenesis in fair/light skin. First, UV-induced DNA damage in the lower epidermis (including keratinocyte stem cells and melanocytes) is more effectively prevented in darker skin. Second, rates of repair of DNA damage can differ significantly in individuals. Third, UV-induced apoptosis to remove potentially precancerous cells is significantly greater in darker skin. These results suggest that pigmented epidermis is an efficient UV filter and that UV damaged cells are removed more efficiently in darker skin. The combination of decreased DNA damage and more efficient removal of UV-damaged cells may play a critical role in the decreased photocarcinogenesis seen in individuals with darker skin. JF - Archives of dermatological research AU - Yamaguchi, Yuji AU - Beer, Janusz Z AU - Hearing, Vincent J AD - Pigment Cell Research Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. yujin@med.nagoya-cu.ac.jp Y1 - 2008/04// PY - 2008 DA - April 2008 SP - S43 EP - S50 VL - 300 Suppl 1 SN - 0340-3696, 0340-3696 KW - Melanins KW - 0 KW - Receptor, Melanocortin, Type 1 KW - Index Medicus KW - Receptor, Melanocortin, Type 1 -- physiology KW - DNA Damage KW - Humans KW - Incidence KW - Apoptosis KW - Melanins -- physiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Ultraviolet Rays -- adverse effects KW - Skin Neoplasms -- epidemiology KW - Epidermis -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70416454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Molecular+Basis+for+Chromatin+Modifications+and+Epigenetic+Phenomena+%28D3%29&rft.atitle=Combinatorial+Patterns+of+Histone+Acetylations+and+Methylations+in+the+Human+Genome&rft.au=Wang%2C+Zhibin&rft.aulast=Wang&rft.aufirst=Zhibin&rft.date=2008-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Molecular+Basis+for+Chromatin+Modifications+and+Epigenetic+Phenomena+%28D3%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-29 N1 - Date created - 2008-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potential pharmacokinetic basis for zolpidem dosing in children with sleep difficulties. AN - 70416016; 17957186 AB - The pharmacokinetics of zolpidem was assessed in this open-label, dose-escalation study in children with insomnia. Twenty-one children, seven per age group (2-6, >6 to 12, >12 to 18 years), received a single dose of zolpidem at one of the three dose levels (0.125, 0.25, or 0.50 mg/kg (20 mg maximum dose)). Multiple pharmacokinetic measures were assessed at nine post-dose intervals and pharmacodynamics was assessed by polysomnography and actigraphy. Significant pharmacokinetic effects by dose were observed only as linear increases in maximum concentration (C(max), P<0.001) and area under the plasma concentration-time curve (AUC, P<0.001). Significant pharmacokinetic effects by age group included an increase in AUC (P=0.02), half-life (P=0.04), and mean residence time (P=0.01), whereas total body clearance decreased (P=0.01) and steady-state volume of distribution was variable. Pharmacodynamic measures were independent of the pharmacokinetic estimates. Overall, zolpidem was well tolerated and a pediatric dose of 0.25 mg/kg is recommended for future efficacy studies. JF - Clinical pharmacology and therapeutics AU - Blumer, J L AU - Reed, M D AU - Steinberg, F AU - O'Riordan, M A AU - Rosen, C L AU - Springer, M A AU - Christensen, M AU - Glaze, D AU - NICHD PPRU Network AD - Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, Ohio, USA. Jeffrey.Blumer@UHhospitals.org ; NICHD PPRU Network Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 551 EP - 558 VL - 83 IS - 4 KW - Hypnotics and Sedatives KW - 0 KW - Pyridines KW - zolpidem KW - 7K383OQI23 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Analysis of Variance KW - Age Factors KW - Area Under Curve KW - Humans KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Sleep Initiation and Maintenance Disorders -- drug therapy KW - Pyridines -- administration & dosage KW - Pyridines -- pharmacokinetics KW - Hypnotics and Sedatives -- administration & dosage KW - Hypnotics and Sedatives -- pharmacokinetics KW - Hypnotics and Sedatives -- adverse effects KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70416016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Potential+pharmacokinetic+basis+for+zolpidem+dosing+in+children+with+sleep+difficulties.&rft.au=Blumer%2C+J+L%3BReed%2C+M+D%3BSteinberg%2C+F%3BO%27Riordan%2C+M+A%3BRosen%2C+C+L%3BSpringer%2C+M+A%3BChristensen%2C+M%3BGlaze%2C+D%3BNICHD+PPRU+Network&rft.aulast=Blumer&rft.aufirst=J&rft.date=2008-04-01&rft.volume=83&rft.issue=4&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-26 N1 - Date created - 2008-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine inhibits basal prolactin release in pituitary lactotrophs through pertussis toxin-sensitive and -insensitive signaling pathways. AN - 70415539; 18096663 AB - Dopamine D2 receptors signal through the pertussis toxin (PTX)-sensitive G(i/o) and PTX-insensitive G(z) proteins, as well as through a G protein-independent, beta-arrestin/glycogen synthase kinase-3-dependent pathway. Activation of these receptors in pituitary lactotrophs leads to inhibition of prolactin (PRL) release. It has been suggested that this inhibition occurs through the G(i/o)-alpha protein-mediated inhibition of cAMP production and/or G(i/o)-betagamma dimer-mediated activation of inward rectifier K(+) channels and inhibition of voltage-gated Ca(2+) channels. Here we show that the dopamine agonist-induced inhibition of spontaneous Ca(2+) influx and release of prestored PRL was preserved when cAMP levels were elevated by forskolin treatment. We further observed that dopamine agonists inhibited both spontaneous and depolarization-induced Ca(2+) influx in untreated but not in PTX-treated cells. This inhibition was also observed in cells with blocked inward rectifier K(+) channels, suggesting that the dopamine effect on voltage-gated Ca(2+) channel gating is sufficient to inhibit spontaneous Ca(2+) influx. However, agonist-induced inhibition of PRL release was only partially relieved in PTX-treated cells, indicating that dopamine receptors also inhibit exocytosis downstream of voltage-gated Ca(2+) influx. The PTX-insensitive step in agonist-induced inhibition of PRL release was not affected by the addition of wortmannin, an inhibitor of phosphatidylinositol 3-kinase, and lithium, an inhibitor of glycogen synthase kinase-3, but was attenuated in the presence of phorbol 12-myristate 13-acetate, which inhibits G(z) signaling pathway in a protein kinase C-dependent manner. Thus, dopamine inhibits basal PRL release by blocking voltage-gated Ca(2+) influx through the PTX-sensitive signaling pathway and by desensitizing Ca(2+) secretion coupling through the PTX-insensitive and protein kinase C-sensitive signaling pathway. JF - Endocrinology AU - Gonzalez-Iglesias, Arturo E AU - Murano, Takayo AU - Li, Shuo AU - Tomić, Melanija AU - Stojilkovic, Stanko S AD - National Institute of Child Health and Human Development, 49 Convent Drive, Bethesda, MD 20892-4510, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 1470 EP - 1479 VL - 149 IS - 4 SN - 0013-7227, 0013-7227 KW - Adenylyl Cyclase Inhibitors KW - 0 KW - Androstadienes KW - Potassium Channels, Inwardly Rectifying KW - Prolactin KW - 9002-62-4 KW - Lithium KW - 9FN79X2M3F KW - Cyclic AMP KW - E0399OZS9N KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Dopamine KW - VTD58H1Z2X KW - wortmannin KW - XVA4O219QW KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Calcium -- metabolism KW - Cyclic AMP -- biosynthesis KW - Animals KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Androstadienes -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Potassium Channels, Inwardly Rectifying -- physiology KW - Female KW - Lithium -- pharmacology KW - Signal Transduction -- physiology KW - Dopamine -- pharmacology KW - Prolactin -- secretion KW - Pertussis Toxin -- pharmacology KW - Pituitary Gland -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70415539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Dopamine+inhibits+basal+prolactin+release+in+pituitary+lactotrophs+through+pertussis+toxin-sensitive+and+-insensitive+signaling+pathways.&rft.au=Gonzalez-Iglesias%2C+Arturo+E%3BMurano%2C+Takayo%3BLi%2C+Shuo%3BTomi%C4%87%2C+Melanija%3BStojilkovic%2C+Stanko+S&rft.aulast=Gonzalez-Iglesias&rft.aufirst=Arturo&rft.date=2008-04-01&rft.volume=149&rft.issue=4&rft.spage=1470&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-06 N1 - Date created - 2008-03-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Oct 29;274(44):31641-7 [10531372] Neuron. 2004 Feb 5;41(3):417-29 [14766180] FASEB J. 2004 Aug;18(11):1270-2 [15180959] Neuron. 2004 Aug 19;43(4):551-62 [15312653] Physiol Rev. 2000 Oct;80(4):1523-631 [11015620] Endocrinology. 2000 Nov;141(11):4091-9 [11089540] Science. 2001 Apr 13;292(5515):293-7 [11303105] Endocrinology. 2001 Jul;142(7):2820-32 [11416001] J Biol Chem. 2001 Sep 7;276(36):33840-6 [11457854] Endocr Rev. 2001 Dec;22(6):724-63 [11739329] Endocrinology. 2002 Jan;143(1):13-22 [11751586] Mol Pharmacol. 2002 Jun;61(6):1329-39 [12021394] Science. 2002 Oct 25;298(5594):781-5 [12399579] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17060-5 [12446844] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17055-9 [12486252] Biochim Biophys Acta. 2003 Aug 18;1641(2-3):157-65 [12914956] Nature. 2004 Sep 23;431(7007):415-22 [15386003] Am J Physiol. 1983 May;244(5):E499-504 [6682634] Mol Pharmacol. 1983 May;23(3):576-84 [6306429] Mol Cell Endocrinol. 1984 Jul;36(3):201-9 [6540722] J Biol Chem. 1987 Apr 5;262(10):4860-7 [3104325] J Biol Chem. 1987 Oct 15;262(29):13920-7 [2443499] J Physiol. 1987 Sep;390:1-22 [3443930] Endocrinology. 1988 Jul;123(1):406-12 [2454806] J Mol Endocrinol. 1988 Nov;1(3):179-86 [2908233] Nature. 1989 Dec 21-28;342(6252):923-6 [2531847] Nature. 1989 Dec 21-28;342(6252):926-9 [2480527] Physiol Rev. 1990 Apr;70(2):279-318 [2181497] Endocrinology. 1990 Sep;127(3):990-1001 [2167220] Endocrinology. 1991 Aug;129(2):1101-3 [1830267] J Neurosci. 1991 Dec;11(12):3727-37 [1683898] Endocrinology. 1992 Feb;130(2):926-32 [1733734] Neuron. 1992 Mar;8(3):455-63 [1312848] Science. 1993 Apr 2;260(5104):82-4 [8385366] Ann N Y Acad Sci. 1994 Mar 9;710:301-18 [8154756] Methods Cell Biol. 1994;40:155-81 [8201975] Br J Pharmacol. 1994 Jul;112(3):728-34 [7921596] Nature. 1995 Aug 17;376(6541):599-602 [7637810] J Biol Chem. 1995 Sep 29;270(39):23119-25 [7559455] Neuron. 1996 Jun;16(6):1209-20 [8663997] Endocrinology. 1996 Dec;137(12):5205-12 [8940336] Neuron. 1997 Jul;19(1):103-13 [9247267] Physiol Rev. 1998 Jan;78(1):189-225 [9457173] J Neurochem. 1998 Jun;70(6):2459-67 [9603210] J Biol Chem. 1999 Mar 12;274(11):7508-15 [10066818] Cell Mol Neurobiol. 1999 Oct;19(5):653-64 [10384262] Science. 2004 Nov 5;306(5698):1042-6 [15528447] Nat Neurosci. 2005 Apr;8(4):421-5 [15778713] J Biol Chem. 2005 Jul 22;280(29):26896-903 [15919662] Cell. 2005 Jul 29;122(2):153-5 [16051141] Cell. 2005 Jul 29;122(2):261-73 [16051150] J Biol Chem. 2006 Jan 20;281(3):1564-72 [16243840] Sci STKE. 2006 Feb 7;2006(321):er2 [16685766] Neuropharmacology. 2006 Sep;51(3):597-605 [16814816] Mol Endocrinol. 2006 Sep;20(9):2231-46 [16645040] J Neurosci. 2007 Apr 25;27(17):4737-46 [17460086] Nature. 2003 Aug 14;424(6950):775-8 [12917685] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15200-5 [14630950] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5099-104 [15044694] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses. AN - 70413832; 18354171 AB - Innate immune responses provide the host with its first line of defense against infections. Signals generated by subsets of lymphocytes, including NK cells, NKT cells, and APC during this early host response determine the nature of downstream adaptive immune responses. In the present study, we have examined the role of innate NK cells in an autoimmune model through the use of primary immunization with the myelin oligodendrocyte glycoprotein peptide to induce experimental autoimmune encephalomyelitis (EAE). Our studies have shown that in vivo depletion of NK cells can affect the adaptive immune responses, because NK cells were found to regulate the degree of clinical paralysis and to alter immune adaptive responses to the myelin oligodendrocyte glycoprotein peptide. The requirement for NK cells was reflected by changes in the T cell responses and diminished clinical disease seen in mice treated with anti-NK1.1, anti-asialo GM1, and selected Ly49 subtype-depleted mice. In addition to alteration in T cell responses, the maturational status of dendritic cells in lymph nodes was altered both quantitatively and qualitatively. Finally, examination of TCR Vbeta usage of the brain lymphocytes from EAE mice indicated a spectra-type change in receptor expression in NK- depleted mice as compared with non-NK-depleted EAE mice. These findings further establish a recently postulated link between NK cells and the generation of autoreactive T cells. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Winkler-Pickett, Robin AU - Young, Howard A AU - Cherry, James M AU - Diehl, John AU - Wine, John AU - Back, Timothy AU - Bere, William E AU - Mason, Anna T AU - Ortaldo, John R AD - Laboratory of Experimental Immunology, Cancer and Inflammation Program, National Cancer Institute-Center for Cancer Research, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 4495 EP - 4506 VL - 180 IS - 7 SN - 0022-1767, 0022-1767 KW - Antigens, Ly KW - 0 KW - Lectins, C-Type KW - Mog protein, mouse KW - Myelin Proteins KW - Myelin-Associated Glycoprotein KW - Myelin-Oligodendrocyte Glycoprotein KW - Receptors, Antigen, T-Cell KW - Receptors, NK Cell Lectin-Like KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Dendritic Cells -- immunology KW - Lectins, C-Type -- immunology KW - Antigens, Ly -- immunology KW - Cells, Cultured KW - Myelin-Associated Glycoprotein -- pharmacology KW - Mice, Inbred C57BL KW - Myelin-Associated Glycoprotein -- immunology KW - Receptors, Antigen, T-Cell -- immunology KW - Mice KW - Encephalomyelitis, Autoimmune, Experimental -- immunology KW - Encephalomyelitis, Autoimmune, Experimental -- chemically induced KW - Adaptation, Physiological -- immunology KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70413832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=In+vivo+regulation+of+experimental+autoimmune+encephalomyelitis+by+NK+cells%3A+alteration+of+primary+adaptive+responses.&rft.au=Winkler-Pickett%2C+Robin%3BYoung%2C+Howard+A%3BCherry%2C+James+M%3BDiehl%2C+John%3BWine%2C+John%3BBack%2C+Timothy%3BBere%2C+William+E%3BMason%2C+Anna+T%3BOrtaldo%2C+John+R&rft.aulast=Winkler-Pickett&rft.aufirst=Robin&rft.date=2008-04-01&rft.volume=180&rft.issue=7&rft.spage=4495&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/10.1016%2Fj.neuroscience.2008.01.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-30 N1 - Date created - 2008-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potential of buprenorphine/naltrexone in treating polydrug addiction and co-occurring psychiatric disorders. AN - 70408255; 18212797 AB - In recent years, we have seen regulatory approval being given for several new pharmacotherapies in the treatment of drug addiction disorders. Within the United States, the most noteworthy development has been the approval of buprenorphine in the treatment of opioid dependence, and its availability for prescribing in an office-based setting has resulted in thousands of additional patients going into treatment. Although approved medications for the treatment of cocaine and methamphetamine dependence are still lacking, the National Institute on Drug Abuse has devoted substantial effort toward meeting these clinical needs. Recent studies of modafinil for the treatment of cocaine dependence have been especially encouraging. Looking to the future, the looming challenge is polydrug addiction, a situation that is often complicated by co-occurring psychiatric disorders. As we strive to address the needs of these complicated patients, studies of buprenorphine/naltrexone may hold the key to a major advance. JF - Clinical pharmacology and therapeutics AU - McCann, D J AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA. dmccann@nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 627 EP - 630 VL - 83 IS - 4 KW - Delayed-Action Preparations KW - 0 KW - Narcotic Antagonists KW - Buprenorphine KW - 40D3SCR4GZ KW - Naltrexone KW - 5S6W795CQM KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Administration Schedule KW - Humans KW - Drug Design KW - Comorbidity KW - Opioid-Related Disorders -- epidemiology KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Opioid-Related Disorders -- complications KW - Mental Disorders -- epidemiology KW - Opioid-Related Disorders -- drug therapy KW - Mental Disorders -- complications KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70408255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Potential+of+buprenorphine%2Fnaltrexone+in+treating+polydrug+addiction+and+co-occurring+psychiatric+disorders.&rft.au=McCann%2C+D+J&rft.aulast=McCann&rft.aufirst=D&rft.date=2008-04-01&rft.volume=83&rft.issue=4&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fsj.clpt.6100503 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-26 N1 - Date created - 2008-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.clpt.6100503 ER - TY - JOUR T1 - Decreased bone mineral density with off-label use of tenofovir in children and adolescents infected with human immunodeficiency virus. AN - 70407681; 18346519 AB - 5 of 6 children infected with human immunodeficiency virus (HIV) receiving Tenofovir disoproxil fumarate (TDF) experienced absolute decreases in bone mineral density (BMD). 2 pre-pubertal subjects experienced >6% BMD decreases. 1 subject was the smallest child and experienced a 27% decrease, necessitating withdrawal of TDF. Subsequently, her BMD recovered. Monitoring of children infected with HIV who require treatment with TDF is warranted. JF - The Journal of pediatrics AU - Purdy, Julia B AU - Gafni, Rachel I AU - Reynolds, James C AU - Zeichner, Steven AU - Hazra, Rohan AD - HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 582 EP - 584 VL - 152 IS - 4 KW - Anti-HIV Agents KW - 0 KW - Organophosphonates KW - Tenofovir KW - 99YXE507IL KW - Adenine KW - JAC85A2161 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Absorptiometry, Photon KW - Child KW - HIV KW - Adolescent KW - Male KW - Female KW - HIV Infections -- physiopathology KW - Bone Density -- drug effects KW - Adenine -- therapeutic use KW - Organophosphonates -- therapeutic use KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Anti-HIV Agents -- therapeutic use KW - Anti-HIV Agents -- pharmacology KW - HIV Infections -- drug therapy KW - Organophosphonates -- pharmacology KW - Adenine -- analogs & derivatives KW - Adenine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70407681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pediatrics&rft.atitle=Decreased+bone+mineral+density+with+off-label+use+of+tenofovir+in+children+and+adolescents+infected+with+human+immunodeficiency+virus.&rft.au=Purdy%2C+Julia+B%3BGafni%2C+Rachel+I%3BReynolds%2C+James+C%3BZeichner%2C+Steven%3BHazra%2C+Rohan&rft.aulast=Purdy&rft.aufirst=Julia&rft.date=2008-04-01&rft.volume=152&rft.issue=4&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pediatrics&rft.issn=1097-6833&rft_id=info:doi/10.1016%2Fj.jpeds.2007.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-03-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 1999 Dec;84(12):4702-12 [10599739] Pediatrics. 2003 Jun;111(6 Pt 1):1416-21 [12777562] Antimicrob Agents Chemother. 2004 Jan;48(1):124-9 [14693529] Calcif Tissue Int. 1996 Nov;59(5):344-51 [8849400] J Acquir Immune Defic Syndr. 2005 Dec 1;40(4):448-50 [16280700] Pediatrics. 2005 Dec;116(6):e846-54 [16291735] Pediatrics. 2006 Sep;118(3):e711-8 [16923923] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jpeds.2007.12.020 ER - TY - JOUR T1 - Bupropion for the treatment of methamphetamine dependence. AN - 70390519; 17581531 AB - Bupropion was tested for efficacy in increasing weeks of abstinence in methamphetamine-dependent patients, compared to placebo. This was a double-blind placebo-controlled study, with 12 weeks of treatment and a 30-day follow-up. Five outpatient substance abuse treatment clinics located west of the Mississippi participated in the study. One hundred and fifty-one treatment-seekers with DSM-IV diagnosis of methamphetamine dependence were consented and enrolled. Seventy-two participants were randomized to placebo and 79 to sustained-release bupropion 150 mg twice daily. Patients were asked to come to the clinic three times per week for assessments, urine drug screens, and 90-min group psychotherapy. The primary outcome was the change in proportion of participants having a methamphetamine-free week. Secondary outcomes included: urine for quantitative methamphetamine, self-report of methamphetamine use, subgroup analyses of balancing factors and comorbid conditions, addiction severity, craving, risk behaviors for HIV, and use of other substances. The generalized estimating equation regression analysis showed that, overall, the difference between bupropion and placebo groups in the probability of a non-use week over the 12-week treatment period was not statistically significant (p=0.09). Mixed model regression was used to allow adjustment for baseline factors in addition to those measured (site, gender, level of baseline use, and level of symptoms of depression). This subgroup analysis showed that bupropion had a significant effect compared to placebo, among male patients who had a lower level of methamphetamine use at baseline (p<0.0001). Comorbid depression and attention-deficit/hyperactivity disorder did not change the outcome. These data suggest that bupropion, in combination with behavioral group therapy, was effective for increasing the number of weeks of abstinence in participants with low-to-moderate methamphetamine dependence, mainly male patients, regardless of their comorbid condition. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Elkashef, Ahmed M AU - Rawson, Richard A AU - Anderson, Ann L AU - Li, Shou-Hua AU - Holmes, Tyson AU - Smith, Edwina V AU - Chiang, Nora AU - Kahn, Roberta AU - Vocci, Frank AU - Ling, Walter AU - Pearce, Valerie J AU - McCann, Michael AU - Campbell, Jan AU - Gorodetzky, Charles AU - Haning, William AU - Carlton, Barry AU - Mawhinney, Joseph AU - Weis, Dennis AD - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences, National Institutes of Health, National Institute on Drug Abuse, Bethesda, MD, USA. ae8a@nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 1162 EP - 1170 VL - 33 IS - 5 SN - 0893-133X, 0893-133X KW - Dopamine Uptake Inhibitors KW - 0 KW - Bupropion KW - 01ZG3TPX31 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Severity of Illness Index KW - Double-Blind Method KW - Humans KW - Adult KW - Treatment Outcome KW - Psychotherapy -- methods KW - Mississippi -- epidemiology KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Methamphetamine -- urine KW - Bupropion -- therapeutic use KW - Methamphetamine -- adverse effects KW - Amphetamine-Related Disorders -- urine KW - Dopamine Uptake Inhibitors -- therapeutic use KW - Amphetamine-Related Disorders -- psychology KW - Amphetamine-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70390519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Bupropion+for+the+treatment+of+methamphetamine+dependence.&rft.au=Elkashef%2C+Ahmed+M%3BRawson%2C+Richard+A%3BAnderson%2C+Ann+L%3BLi%2C+Shou-Hua%3BHolmes%2C+Tyson%3BSmith%2C+Edwina+V%3BChiang%2C+Nora%3BKahn%2C+Roberta%3BVocci%2C+Frank%3BLing%2C+Walter%3BPearce%2C+Valerie+J%3BMcCann%2C+Michael%3BCampbell%2C+Jan%3BGorodetzky%2C+Charles%3BHaning%2C+William%3BCarlton%2C+Barry%3BMawhinney%2C+Joseph%3BWeis%2C+Dennis&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2008-04-01&rft.volume=33&rft.issue=5&rft.spage=1162&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-01 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues. AN - 70389281; 18312271 AB - We have shown previously that lack of molybdenum cofactor (MoCo) in Escherichia coli leads to hypersensitivity to the mutagenic and toxic effects of N-hydroxylated base analogues, such as 6-N-hydroxylaminopurine (HAP). However, the nature of the MoCo-dependent mechanism is unknown, as inactivation of all known and putative E. coli molybdoenzymes does not produce any sensitivity. Presently, we report on the isolation and characterization of two novel HAP-hypersensitive mutants carrying defects in the ycbX or yiiM open reading frames. Genetic analysis suggests that the two genes operate within the MoCo-dependent pathway. In the absence of the ycbX- and yiiM-dependent pathways, biotin sulfoxide reductase plays also a role in the detoxification pathway. YcbX and YiiM are hypothetical members of the MOSC protein superfamily, which contain the C-terminal domain (MOSC) of the eukaryotic MoCo sulphurases. However, deletion of ycbX or yiiM did not affect the activity of human xanthine dehydrogenase expressed in E. coli, suggesting that the role of YcbX and YiiM proteins is not related to MoCo sulphuration. Instead, YcbX and YiiM may represent novel MoCo-dependent enzymatic activities. We also demonstrate that the MoCo/YcbX/YiiM-dependent detoxification of HAP proceeds by reduction to adenine. JF - Molecular microbiology AU - Kozmin, Stanislav G AU - Leroy, Prune AU - Pavlov, Youri I AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 51 EP - 65 VL - 68 IS - 1 KW - Escherichia coli Proteins KW - 0 KW - Hydroxylamine KW - 2FP81O2L9Z KW - 6-N-hydroxylaminopurine KW - 5667-20-9 KW - Molybdenum KW - 81AH48963U KW - Oxidoreductases KW - EC 1.- KW - biotin sulfoxide reductase KW - Xanthine Dehydrogenase KW - EC 1.17.1.4 KW - Adenine KW - JAC85A2161 KW - Index Medicus KW - Xanthine Dehydrogenase -- genetics KW - Mutagenesis -- drug effects KW - Oxidoreductases -- genetics KW - Oxidoreductases -- metabolism KW - Molybdenum -- metabolism KW - Xanthine Dehydrogenase -- metabolism KW - Protein Structure, Tertiary KW - Open Reading Frames -- genetics KW - Mutation KW - Hydroxylamine -- pharmacology KW - Mutagenesis, Insertional KW - Escherichia coli Proteins -- chemistry KW - Escherichia coli Proteins -- metabolism KW - Escherichia coli -- metabolism KW - Drug Resistance, Bacterial -- genetics KW - Escherichia coli -- drug effects KW - Escherichia coli -- genetics KW - Adenine -- analogs & derivatives KW - Escherichia coli Proteins -- genetics KW - Adenine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70389281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=YcbX+and+yiiM%2C+two+novel+determinants+for+resistance+of+Escherichia+coli+to+N-hydroxylated+base+analogues.&rft.au=Kozmin%2C+Stanislav+G%3BLeroy%2C+Prune%3BPavlov%2C+Youri+I%3BSchaaper%2C+Roel+M&rft.aulast=Kozmin&rft.aufirst=Stanislav&rft.date=2008-04-01&rft.volume=68&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=1365-2958&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06128.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-03 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Acta Biochim Pol. 1998;45(3):645-52 [9918490] Yeast. 1996 Jan;12(1):17-29 [8789257] Nat Struct Biol. 1999 Jul;6(7):691-6 [10404228] J Biol Chem. 1956 Nov;223(1):327-39 [13376602] J Biol Chem. 1956 Jan;218(1):97-106 [13278318] J Bacteriol. 2005 Jan;187(1):231-7 [15601707] Nucleic Acids Res. 2005 Jan 1;33(Database issue):D192-6 [15608175] Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3129-34 [15710899] Biochim Biophys Acta. 2006 Jul;1763(7):621-35 [16784786] J Biol Chem. 2006 Nov 17;281(46):34796-802 [16973608] J Biol Chem. 2007 Feb 9;282(6):3531-8 [17090528] Mol Genet Metab. 2007 May;91(1):23-9 [17368066] Mutat Res. 2007 Jun 1;619(1-2):9-15 [17349664] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] J Bacteriol. 2000 Jun;182(12):3361-7 [10852865] J Bacteriol. 2000 Oct;182(19):5332-41 [10986234] Mol Microbiol. 2000 Oct;38(1):114-25 [11029694] Genome Res. 2001 Jul;11(7):1246-55 [11435407] Biosci Biotechnol Biochem. 2001 May;65(5):1112-8 [11440125] FEMS Microbiol Lett. 2002 Jan 22;207(1):55-61 [11886751] J Biol Chem. 2002 Jun 28;277(26):23374-81 [11970951] Trends Biochem Sci. 2002 Jul;27(7):360-7 [12114025] Plant J. 2002 Aug;31(3):305-17 [12164810] J Bacteriol. 2002 Nov;184(21):5898-902 [12374823] Mutat Res. 1996 Oct 25;357(1-2):1-15 [8876675] J Biol Chem. 1997 Feb 7;272(6):3355-62 [9013576] Mutat Res. 1997 Sep 5;379(1):95-103 [9330627] Mutat Res. 1998 Jun 18;402(1-2):41-50 [9675240] Microbiol Mol Biol Rev. 1998 Sep;62(3):814-984 [9729611] Biochem J. 1998 Oct 15;335 ( Pt 2):233-40 [9761719] Prog Biophys Mol Biol. 1998;70(2):95-136 [9785959] J Bacteriol. 2003 May;185(10):3101-10 [12730170] Nucleic Acids Res. 1975 Jul;2(7):1143-51 [1098023] Prog Nucleic Acid Res Mol Biol. 1976;16:125-88 [2946] Appl Environ Microbiol. 1977 Feb;33(2):434-44 [322611] Acta Biochim Pol. 1977;24(3):197-205 [22212] Mutat Res. 1978 Jan;56(3):225-34 [342940] Acta Biochim Pol. 1979;26(1-2):171-7 [388954] Mutat Res. 1981 May;91(3):193-7 [7017397] Proc Natl Acad Sci U S A. 1981 Sep;78(9):5685-9 [6946507] J Bacteriol. 1982 Feb;149(2):469-78 [6460021] J Bacteriol. 1982 Aug;151(2):788-99 [7047497] Mutat Res. 1983 Apr;114(3):217-67 [6300670] Proc Natl Acad Sci U S A. 1983 Aug;80(15):4639-43 [6308634] J Mol Biol. 1986 May 5;189(1):113-30 [3537305] Science. 1989 Apr 7;244(4900):41-7 [2649979] Biochem Pharmacol. 1990 Mar 1;39(5):925-33 [2310418] J Bacteriol. 1990 Apr;172(4):2194-8 [2180922] Mutat Res. 1991 Aug;253(1):33-46 [1870608] Methods Enzymol. 1991;204:139-80 [1658561] Biochem Pharmacol. 1992 Oct 20;44(8):1501-9 [1417974] Mol Microbiol. 1992 Nov;6(22):3452-4 [1484496] PCR Methods Appl. 1993 Oct;3(2):85-94 [8268791] FEMS Microbiol Rev. 1998 Dec;22(5):503-21 [9990727] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06128.x ER - TY - JOUR T1 - Circulating endothelial cells as a therapeutic marker for thalidomide in combined therapy with chemotherapy drugs in a human prostate cancer model. AN - 70370962; 18070197 AB - To investigate how thalidomide confers its survival benefit in prostate cancer, by assessing its effect on circulating endothelial cells (CECs) and progenitors (CEPs) in a combined therapy of thalidomide and chemotherapy drugs in a human prostate cancer xenograft model, as in clinical trials patients treated with both thalidomide and docetaxel had a >50% decrease in prostate-specific antigen (PSA) levels and longer median overall survival than those treated with docetaxel monotherapy. A human prostate cancer xenograft model was used to evaluate the effect of either thalidomide, docetaxel or a combination of the two drugs on circulating ECs. Drug treatment was continued for 17 days, and tumours were measured two or three times a week. Blood samples were taken at three different time points: before the treatments, 4 days and 17 days into the treatments, and CECs and CEPs were measured by flow cytometry analysis. There was an increased level of apoptotic/dead CECs shortly after the intravenous injection of docetaxel, and the addition of thalidomide further increased the apoptotic/dead CEC level, showing that thalidomide enhances the cytotoxicity of docetaxel against tumour vascular ECs. Thalidomide increased the apoptotic/dead CEC level and enhanced the cytotoxicity of docetaxel against tumour vascular ECs, confirming its antiangiogenic property in vivo in combined anticancer treatments. In addition, there was a correlation between the increased apoptotic/dead CEC levels early in the treatment and antitumour efficacy later, suggesting that the apoptotic/dead CEC level could be used as a marker, at an early stage, to predict tumour response to antiangiogenic therapies. JF - BJU international AU - Li, Haiqing AU - Raia, Valentina AU - Bertolini, Francesco AU - Price, Douglas K AU - Figg, William D AD - Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 884 EP - 888 VL - 101 IS - 7 KW - Angiogenesis Inhibitors KW - 0 KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - Estramustine KW - 35LT29625A KW - Thalidomide KW - 4Z8R6ORS6L KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Stem Cells -- drug effects KW - Neoplasm Transplantation KW - Animals KW - Random Allocation KW - Humans KW - Estramustine -- administration & dosage KW - Transplantation, Heterologous KW - Mice KW - Mice, SCID KW - Drug Synergism KW - Male KW - Cisplatin -- administration & dosage KW - Angiogenesis Inhibitors -- therapeutic use KW - Prostatic Neoplasms -- pathology KW - Endothelial Cells -- drug effects KW - Thalidomide -- administration & dosage KW - Thalidomide -- therapeutic use KW - Taxoids -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Taxoids -- administration & dosage KW - Angiogenesis Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70370962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BJU+international&rft.atitle=Circulating+endothelial+cells+as+a+therapeutic+marker+for+thalidomide+in+combined+therapy+with+chemotherapy+drugs+in+a+human+prostate+cancer+model.&rft.au=Li%2C+Haiqing%3BRaia%2C+Valentina%3BBertolini%2C+Francesco%3BPrice%2C+Douglas+K%3BFigg%2C+William+D&rft.aulast=Li&rft.aufirst=Haiqing&rft.date=2008-04-01&rft.volume=101&rft.issue=7&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=BMC+psychiatry&rft.issn=1471-244X&rft_id=info:doi/10.1186%2F1471-244X-8-22 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. AN - 70365177; 18158907 AB - Finding specific small-molecule inhibitors of protein-protein interactions remains a significant challenge. Recently, attention has grown toward "hot spot" interactions where binding is dominated by a limited number of amino acid contacts, theoretically offering an increased opportunity for disruption by small molecules. Inhibitors of the interaction between BRCT (the C-terminal portion of BRCA1, a key tumor suppressor protein with various functions) and phosphorylated proteins (Abraxas/BACH1/CtIP), implicated in DNA damage response and repair pathways, should prove to be useful in studying BRCA1's role in cancer and in potentially sensitizing tumors to chemotherapeutic agents. We developed and miniaturized to a 1536-well format and 3-mul final volume a pair of fluorescence polarization (FP) assays using fluorescein- and rhodamine-labeled pBACH1 fragment. To minimize the effect of fluorescence artifacts and to increase the overall robustness of the screen, the 75,552 compound library members all were assayed against both the fluorescein- and rhodamine-labeled probe-protein complexes in separate but interleaved reactions. In addition, every library compound was tested over a range of concentrations following the quantitative high-throughput screening (qHTS) paradigm. Analyses of the screening results led to the selection and subsequent confirmation of 16 compounds active in both assays. Faced with a traditionally difficult protein-protein interaction assay, by performing two-fluorophore qHTS, we were able to confidently select a number of actives for further studies. JF - Analytical biochemistry AU - Simeonov, Anton AU - Yasgar, Adam AU - Jadhav, Ajit AU - Lokesh, G L AU - Klumpp, Carleen AU - Michael, Sam AU - Austin, Christopher P AU - Natarajan, Amarnath AU - Inglese, James AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 60 EP - 70 VL - 375 IS - 1 SN - 0003-2697, 0003-2697 KW - BRCA1 Protein KW - 0 KW - Fluorescent Dyes KW - Pharmaceutical Preparations KW - Phosphoproteins KW - Small Molecule Libraries KW - Index Medicus KW - Drug Stability KW - Pharmaceutical Preparations -- chemistry KW - Dose-Response Relationship, Drug KW - Miniaturization KW - Inhibitory Concentration 50 KW - Protein Binding KW - Drug Storage KW - Fluorescent Dyes -- metabolism KW - BRCA1 Protein -- metabolism KW - Drug Evaluation, Preclinical -- methods KW - BRCA1 Protein -- chemistry KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70365177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+biochemistry&rft.atitle=Dual-fluorophore+quantitative+high-throughput+screen+for+inhibitors+of+BRCT-phosphoprotein+interaction.&rft.au=Simeonov%2C+Anton%3BYasgar%2C+Adam%3BJadhav%2C+Ajit%3BLokesh%2C+G+L%3BKlumpp%2C+Carleen%3BMichael%2C+Sam%3BAustin%2C+Christopher+P%3BNatarajan%2C+Amarnath%3BInglese%2C+James&rft.aulast=Simeonov&rft.aufirst=Anton&rft.date=2008-04-01&rft.volume=375&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Analytical+biochemistry&rft.issn=00032697&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-01 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2006 Apr 21;312(5772):377-8 [16627730] Anal Biochem. 2006 May 1;352(1):135-41 [16500609] J Biomol Screen. 2006 Apr;11(3):253-61 [16490778] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] J Biomol Screen. 2007 Feb;12(1):100-5 [17175524] J Med Chem. 2007 May 17;50(10):2385-90 [17447748] Science. 2007 May 25;316(5828):1194-8 [17525340] Science. 2007 May 25;316(5828):1198-202 [17525341] Science. 2007 May 25;316(5828):1202-5 [17525342] Nat Chem Biol. 2007 Aug;3(8):466-79 [17637779] Nat Struct Mol Biol. 2007 Aug;14(8):716-20 [17643121] Nat Struct Mol Biol. 2007 Aug;14(8):710-5 [17643122] J Am Chem Soc. 2007 Sep 5;129(35):10658-9 [17685618] PLoS Negl Trop Dis. 2008;2(1):e127 [18235848] Electrophoresis. 2001 Jan;22(1):134-8 [11197162] Cell. 2001 Apr 6;105(1):149-60 [11301010] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1603-8 [12582206] J Biomol Screen. 2003 Apr;8(2):205-9 [12844442] J Biomol Screen. 2003 Jun;8(3):292-304 [12857383] Science. 2003 Oct 24;302(5645):636-9 [14576432] Science. 2003 Oct 24;302(5645):639-42 [14576433] J Biol Chem. 2003 Dec 26;278(52):52914-8 [14578343] Nat Rev Drug Discov. 2004 Apr;3(4):301-17 [15060526] Mol Cell. 2004 May 7;14(3):405-12 [15125843] Nat Struct Mol Biol. 2004 Jun;11(6):512-8 [15133502] Nat Struct Mol Biol. 2004 Jun;11(6):519-25 [15133503] Structure. 2004 Jul;12(7):1137-46 [15242590] Mol Cell Biol. 2004 Nov;24(21):9478-86 [15485915] J Mol Biol. 1998 Jul 3;280(1):1-9 [9653027] J Biol Chem. 1998 Sep 25;273(39):25388-92 [9738006] Science. 2004 Nov 12;306(5699):1138-9 [15542455] Assay Drug Dev Technol. 2005 Apr;3(2):189-202 [15871693] Assay Drug Dev Technol. 2005 Apr;3(2):213-25 [15871695] Biochemistry. 2005 Aug 23;44(33):10941-6 [16101277] Nat Chem Biol. 2005 Aug;1(3):146-8 [16408018] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of endocrine disruptors on obesity. AN - 70350700; 18315718 AB - Environmental chemicals with hormone-like activity can disrupt the programming of endocrine signalling pathways that are established during perinatal life and result in adverse consequences that may not be apparent until much later in life. Increasing evidence implicates developmental exposure to environmental hormone mimics with a growing list of adverse health consequences in both males and females. Most recently, obesity has been proposed to be yet another adverse health effect of exposure to endocrine disrupting chemicals (EDCs) during critical stages of development. Obesity is quickly becoming a significant human health crisis because it is reaching epidemic proportions worldwide, and is associated with chronic illnesses such as diabetes and cardiovascular disease. In this review, we summarize the literature reporting an association of EDCs and the development of obesity, and further describe an animal model of exposure to diethylstilbestrol that has proven useful in studying mechanisms involved in abnormal programming of various oestrogen target tissues during differentiation. Together, these data suggest new targets (i.e. adipocyte differentiation and mechanisms involved in weight homeostasis) of abnormal programming by EDCs, and provide evidence that support the scientific term 'the developmental origins of adult disease'. The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers. JF - International journal of andrology AU - Newbold, Retha R AU - Padilla-Banks, Elizabeth AU - Jefferson, Wendy N AU - Heindel, Jerrold J AD - Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. newbold1@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 201 EP - 208 VL - 31 IS - 2 KW - Endocrine Disruptors KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Adult KW - Disease Models, Animal KW - Mice KW - Fetus -- physiopathology KW - Male KW - Female KW - Endocrine Disruptors -- toxicity KW - Obesity -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70350700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+andrology&rft.atitle=Effects+of+endocrine+disruptors+on+obesity.&rft.au=Newbold%2C+Retha+R%3BPadilla-Banks%2C+Elizabeth%3BJefferson%2C+Wendy+N%3BHeindel%2C+Jerrold+J&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2008-04-01&rft.volume=31&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=International+journal+of+andrology&rft.issn=1365-2605&rft_id=info:doi/10.1111%2Fj.1365-2605.2007.00858.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-04 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2605.2007.00858.x ER - TY - JOUR T1 - Understanding the risk of using medications for attention deficit hyperactivity disorder with respect to physical growth and cardiovascular function. AN - 70331130; 18295156 AB - The effects of stimulant medications and atomoxetine on physical growth and on cardiovascular function are reviewed in light of the most recent data, with attention to clinical implications and research needs. Although these medications have a favorable benefit/risk profile and do not induce clinically significant changes in growth or cardiovascular function in the majority of cases, careful patient monitoring is needed to identify individuals at risk for negative outcomes. More research is needed to elucidate the mechanism of growth suppression to estimate better the risk for rare but life-threatening events and test the effectiveness of monitoring procedures. JF - Child and adolescent psychiatric clinics of North America AU - Vitiello, Benedetto AD - Child and Adolescent Treatment and Preventive Intervention Research Branch, Division of Services and Intervention Research, National Institute of Mental Health, Room 7147, 6001 Executive Boulevard, Bethesda, MD 20892-9633, USA. bvitiell@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 459 EP - 74, xi VL - 17 IS - 2 SN - 1056-4993, 1056-4993 KW - Adrenergic Uptake Inhibitors KW - 0 KW - Central Nervous System Stimulants KW - Propylamines KW - Methylphenidate KW - 207ZZ9QZ49 KW - Atomoxetine Hydrochloride KW - 57WVB6I2W0 KW - Index Medicus KW - Adrenergic Uptake Inhibitors -- adverse effects KW - Humans KW - Methylphenidate -- therapeutic use KW - Appetite -- drug effects KW - Child KW - Child, Preschool KW - Controlled Clinical Trials as Topic KW - Risk Factors KW - Methylphenidate -- adverse effects KW - Adrenergic Uptake Inhibitors -- therapeutic use KW - Long-Term Care KW - Adolescent KW - Heart Rate -- drug effects KW - Central Nervous System Stimulants -- therapeutic use KW - Central Nervous System Stimulants -- adverse effects KW - Blood Pressure -- drug effects KW - Death, Sudden, Cardiac -- etiology KW - Body Height -- drug effects KW - Electrocardiography -- drug effects KW - Attention Deficit Disorder with Hyperactivity -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70331130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+and+adolescent+psychiatric+clinics+of+North+America&rft.atitle=Understanding+the+risk+of+using+medications+for+attention+deficit+hyperactivity+disorder+with+respect+to+physical+growth+and+cardiovascular+function.&rft.au=Vitiello%2C+Benedetto&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2008-04-01&rft.volume=17&rft.issue=2&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Child+and+adolescent+psychiatric+clinics+of+North+America&rft.issn=10564993&rft_id=info:doi/10.1016%2Fj.chc.2007.11.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-16 N1 - Date created - 2008-02-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Psychiatry. 2004 May;161(5):918-20 [15121661] J Child Adolesc Psychopharmacol. 2002 Spring;12(1):55-61 [12014596] Arch Gen Psychiatry. 1983 Mar;40(3):317-21 [6830410] N Engl J Med. 1972 Aug 3;287(5):217-20 [4556640] N Engl J Med. 2006 Apr 6;354(14):1445-8 [16549404] Health Aff (Millwood). 2007 Mar-Apr;26(2):450-7 [17339673] J Child Adolesc Psychopharmacol. 2005 Apr;15(2):191-202 [15910204] J Pediatr. 2005 Sep;147(3):348-54 [16182674] J Pediatr Endocrinol Metab. 2003 Jun;16(5):711-8 [12880120] Neuron. 1997 Jul;19(1):127-38 [9247269] Pediatrics. 2001 Oct;108(4):1033-44 [11581465] Biol Psychiatry. 2007 Mar 1;61(5):706-12 [16899230] J Clin Psychiatry. 2005 Feb;66(2):253-9 [15705013] Horm Res. 2005;63(4):159-64 [15795512] J Am Acad Child Adolesc Psychiatry. 2007 Feb;46(2):150-1 [17242617] Pediatrics. 2004 Apr;113(4):762-9 [15060225] Pediatr Dent. 2005 Jul-Aug;27(4):292-7 [16317968] J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):180-7 [11211366] Pediatrics. 2006 Sep;118(3):1215-9 [16951018] J Am Acad Child Adolesc Psychiatry. 2006 May;45(5):520-6 [16670648] Biol Psychiatry. 2006 May 1;59(9):829-35 [16373066] J Am Acad Child Adolesc Psychiatry. 2000 Apr;39(4):517-24 [10761355] Psychopharmacology (Berl). 2003 Mar;166(3):264-70 [12589522] Arch Gen Psychiatry. 1988 Dec;45(12):1131-4 [3058089] Pediatrics. 2001 Oct;108(4):883-92 [11581440] Arch Gen Psychiatry. 1999 Dec;56(12):1073-86 [10591283] J Clin Psychopharmacol. 2004 Feb;24(1):36-41 [14709945] Am J Cardiol. 1986 Jun 1;57(15):1410-3 [3717045] Arch Dis Child. 2005 Aug;90(8):801-6 [16040876] CNS Spectr. 2005 Dec;10(12 Suppl 20):35-43 [16344839] J Am Acad Child Psychiatry. 1981 Winter;20(1):84-103 [7217554] N Engl J Med. 1996 Apr 18;334(16):1039-44 [8598843] Biol Psychiatry. 2005 Mar 1;57(5):456-63 [15737659] Pediatrics. 1997 Oct;100(4):662-6 [9310521] Drug Saf. 2003;26(10):729-40 [12862507] Psychoneuroendocrinology. 1981 Dec;6(4):331-9 [7323251] CNS Spectr. 2005 Oct;10(10 Suppl 15):22-30 [17151573] Res Dev Disabil. 2006 Mar-Apr;27(2):162-74 [15955659] J Am Acad Child Adolesc Psychiatry. 2007 Aug;46(8):1015-27 [17667480] J Child Adolesc Psychopharmacol. 2007 Oct;17(5):593-604 [17979580] Am J Psychiatry. 2006 Apr;163(4):579-85 [16585430] Arch Gen Psychiatry. 2005 Nov;62(11):1266-74 [16275814] J Am Acad Child Adolesc Psychiatry. 1996 Nov;35(11):1460-9 [8936912] J Am Acad Child Psychiatry. 1984 Jan;23(1):58-67 [6693678] Arch Gen Psychiatry. 1988 Dec;45(12):1127-30 [3058088] J Am Acad Child Adolesc Psychiatry. 2006 Nov;45(11):1304-13 [17023868] J Am Acad Child Adolesc Psychiatry. 2006 Aug;45(8):919-27 [16865034] J Am Acad Child Adolesc Psychiatry. 2005 Oct;44(10):1015-23 [16175106] J Am Acad Child Adolesc Psychiatry. 2006 Nov;45(11):1294-303 [17028508] Arch Gen Psychiatry. 1979 Feb;36(2):212-7 [420542] J Pediatr. 1975 Jan;86(1):113-6 [1110433] Psychopharmacology (Berl). 2007 Oct;194(2):197-209 [17572882] J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):188-96 [11211367] J Am Acad Child Adolesc Psychiatry. 1999 Aug;38(8):1047-50 [10434498] Pediatr Nephrol. 2006 Jan;21(1):92-5 [16254730] Pediatrics. 2005 Jul;116(1):e74-80 [15995021] Nord J Psychiatry. 2002;56(1):53-7 [11869467] J Am Acad Child Adolesc Psychiatry. 1999 May;38(5):614-9; discussion 619-22 [10230195] J Am Acad Child Adolesc Psychiatry. 2006 May;45(5):527-37 [16670649] Ann Pharmacother. 2005 Jun;39(6):1045-8 [15870137] Pediatrics. 2003 May;111(5 Pt 1):1010-6 [12728081] J Clin Psychiatry. 1995 Mar;56(3):87-93 [7883735] J Paediatr Child Health. 2003 Apr;39(3):180-5 [12654140] J Am Acad Child Adolesc Psychiatry. 2001 May;40(5):525-9 [11349696] J Am Acad Child Adolesc Psychiatry. 2002 Feb;41(2 Suppl):26S-49S [11833633] Curr Opin Pediatr. 2002 Apr;14(2):219-23 [11981294] Pediatrics. 2003 Jan;111(1):179-85 [12509574] J Am Acad Child Adolesc Psychiatry. 2006 Apr;45(4):415-21 [16601646] Am J Psychiatry. 2006 Jul;163(7):1149-52 [16816217] J Am Acad Child Adolesc Psychiatry. 2006 Jun;45(6):642-57 [16721314] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chc.2007.11.010 ER - TY - JOUR T1 - Contingency management reduces injection-related HIV risk behaviors in heroin and cocaine using outpatients. AN - 70254897; 18068905 AB - Intravenous drug use is a major vector of HIV transmission. We assessed whether contingency management (CM), in which participants earn reinforcers for drug abstinence, reduces HIV risk behaviors in methadone-maintained opiate- and cocaine-using outpatients. Participants (n=116) were randomly assigned to prize-based CM or to receipt of prize draws noncontingently on a schedule yoked to the CM group. Both groups received methadone and individual counseling throughout treatment. The HIV-Risk Taking Behaviour Scale was administered in written questionnaire form at 2-week intervals (HRBS; [Darke, S., Hall, W., Heather, N., Ward, J., & Wodak, A. (1991). The reliability and validity of a scale to measure HIV risk-taking behaviour among intravenous drug users. AIDS, 5, 181-185]). A mediation analysis was conducted to determine whether abstinence from opiates and cocaine mediated the effect of CM on HRBS scores. Changes in HRBS scores over time differed significantly by treatment (F(9,334)=2.4, p<0.05), with HRBS scores decreasing over time in the CM group to a greater extent than in the noncontingent control group. Participants in the CM group had significantly lower rates of simultaneous cocaine/opiate-positive urine specimens than those in the noncontingent control group during CM treatment (F(1,111)=6.8, p=0.01). The relationship between treatment condition and HRBS scores was mediated by abstinence. CM targeted toward cocaine and heroin use produces significant reductions in injection-related drug-taking behaviors associated with heightened risk for getting or transmitting HIV. JF - Addictive behaviors AU - Ghitza, Udi E AU - Epstein, David H AU - Preston, Kenzie L AD - Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. ghitzau@intra.nida.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 593 EP - 604 VL - 33 IS - 4 SN - 0306-4603, 0306-4603 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Substance Abuse Treatment Centers KW - Substance Abuse, Intravenous -- rehabilitation KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Counseling KW - Adolescent KW - Male KW - Female KW - Methadone -- therapeutic use KW - Reward KW - HIV Infections -- prevention & control KW - Narcotics -- therapeutic use KW - Heroin Dependence -- rehabilitation KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70254897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Contingency+management+reduces+injection-related+HIV+risk+behaviors+in+heroin+and+cocaine+using+outpatients.&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2008-04-01&rft.volume=33&rft.issue=4&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-21 N1 - Date created - 2008-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Clin Psychopharmacol. 1999 Nov;7(4):399-411 [10609975] J Consult Clin Psychol. 2007 Oct;75(5):765-74 [17907858] Drug Alcohol Depend. 2000 Feb 1;58(1-2):205-12 [10669073] Drug Alcohol Depend. 2000 Apr 1;59(1):17-31 [10706972] Exp Clin Psychopharmacol. 2000 May;8(2):176-84 [10843300] Exp Clin Psychopharmacol. 2000 Aug;8(3):377-86 [10975629] J Urban Health. 2000 Sep;77(3):331-45 [10976608] Addiction. 2000 Oct;95(10):1475-90 [11070524] J Subst Abuse Treat. 2000 Dec;19(4):319-28 [11166496] J Acquir Immune Defic Syndr. 2001 Apr 15;26(5):483-9 [11391170] J Subst Abuse Treat. 2001 Sep;21(2):89-96 [11551737] Subst Use Misuse. 2001 Oct;36(12):1731-47 [11758820] J Consult Clin Psychol. 2002 Apr;70(2):398-405 [11952198] Drug Alcohol Depend. 2002 Jul 1;67(2):125-37 [12095662] Addiction. 2004 Mar;99(3):349-60 [14982548] Exp Clin Psychopharmacol. 2004 May;12(2):147-55 [15122959] Drug Alcohol Depend. 2004 Jul 15;75(1):97-106 [15225893] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] J Pers Soc Psychol. 1986 Dec;51(6):1173-82 [3806354] AIDS. 1991 Feb;5(2):181-5 [2031690] Am J Psychiatry. 1991 Sep;148(9):1218-24 [1883001] J Consult Clin Psychol. 1992 Dec;60(6):927-34 [1460154] Am J Psychiatry. 1993 May;150(5):763-9 [8480823] Public Health Rep. 1994 Jul-Aug;109(4):548-54 [8041855] Arch Gen Psychiatry. 1996 May;53(5):409-15 [8624184] Drug Alcohol Depend. 1996 Jun;41(2):157-65 [8809505] J Consult Clin Psychol. 1997 Apr;65(2):252-61 [9086688] Public Health Rep. 1998 Jun;113 Suppl 1:97-106 [9722815] J Consult Clin Psychol. 1998 Aug;66(4):691-6 [9735588] J Consult Clin Psychol. 1998 Oct;66(5):761-7 [9803694] Sex Transm Infect. 1998 Aug;74(4):253-5 [9924463] Drug Alcohol Depend. 1999 Mar 1;54(1):69-81 [10101619] AIDS. 1999 Oct 1;13(14):1807-18 [10513638] Drug Alcohol Depend. 2005 May 9;78(2):125-34 [15845315] Arch Gen Psychiatry. 2005 Oct;62(10):1148-56 [16203960] J Consult Clin Psychol. 2005 Dec;73(6):1005-14 [16392974] Addiction. 2006 Feb;101(2):192-203 [16445548] Arch Gen Psychiatry. 2006 Feb;63(2):201-8 [16461864] Addict Behav. 2006 May;31(5):868-79 [16085366] Curr HIV/AIDS Rep. 2006 Nov;3(4):154-9 [17032574] Addiction. 2006 Nov;101(11):1546-60 [17034434] AIDS Patient Care STDS. 2007 Jan;21(1):30-40 [17263651] Drug Alcohol Depend. 2007 Apr 17;88(1):54-63 [17056206] J Consult Clin Psychol. 2007 Apr;75(2):307-15 [17469888] Drug Alcohol Depend. 2000 Feb 1;58(1-2):55-66 [10669055] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Real-time PCR assay for rapid detection of GSTM1 polymorphism in nasopharyngeal carcinoma patients. AN - 69451770; 18712965 AB - Nasopharyngeal carcinoma (NPC) is a common public health problem in Thailand. Glutathione S-transferase M1 gene deletion (GSTM1 null genotype) carriers have been reported to be at increased risk and therefore this parameter is a potential marker for screening of NPC high-risk individuals. However, the conventional polymerase chain reaction (C-PCR) assay commonly used for GSTM1 null genotype detection is not suitable for mass screening since it is inconvenient, time consuming and unsafe due to the use of a toxic chemical. Currently, real-time PCR (R-PCR) assay is recommended for quicker and safer detection of various genetic polymorphisms. The aim of this study was to develop a SYBR green I R-PCR assay combined with melting curve analysis for GSTM1 polymorphism detection in Thai NPC patients. The results were compared to those from the C-PCR assay using DNA samples from peripheral blood leukocytes of 120 Thai NPC patients. The frequencies of GSTM1 polymorphism detected by the R-PCR and the C-PCR were the same. Forty-eight individuals that were GSTM1+ in the R-PCR assay showed 2 peaks with melting points of 82.5 and 87.5 that correlated with the appearance of 2 DNA bands in the C-PCR assay (i.e., one for GSTM1 at 215 base pairs (bp) and one for ?-globin at 268 bp). By contrast, 72 individuals that were GSTM1?- in the R-PCR assay showed 1 peak with a melting point of 87.5C that correlated with the appearance of 1 DNA band for -globin at 268 bp in the C-PCR assay. The R-PCR assay using SYBR Green I and melting curve analysis for GSTM1 polymorphism detection was as reliable as C-PCR assay but was quicker and safer and more amenable to large scale screening in Thai NPC cases. JF - Asian Pacific journal of cancer prevention : APJCP AU - Tiwawech, Danai AU - Chindavijak, Somjin AU - Karalak, Anant AU - Ishida, Takafumi AD - Research Division, National Cancer Institute, Bangkok 10400, Thailand. tdanai@hotmail.com PY - 2008 SP - 233 EP - 237 VL - 9 IS - 2 SN - 1513-7368, 1513-7368 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Humans KW - Thailand -- epidemiology KW - Genetic Predisposition to Disease KW - Polymorphism, Genetic -- genetics KW - Polymerase Chain Reaction -- methods KW - Glutathione Transferase -- genetics KW - Nasopharyngeal Neoplasms -- genetics KW - Nasopharyngeal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69451770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Real-time+PCR+assay+for+rapid+detection+of+GSTM1+polymorphism+in+nasopharyngeal+carcinoma+patients.&rft.au=Tiwawech%2C+Danai%3BChindavijak%2C+Somjin%3BKaralak%2C+Anant%3BIshida%2C+Takafumi&rft.aulast=Tiwawech&rft.aufirst=Danai&rft.date=2008-04-01&rft.volume=9&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic management of posttransplant diabetes mellitus. AN - 69315513; 18631864 AB - Diabetes mellitus continues to be a common metabolic complication after solid organ transplantation. The etiology is multifactorial and includes both modifiable and nonmodifiable factors. Immunosuppression may play a critical role in its development. Targets of treatment include oral hypoglycemics as well as insulin. More recently, several novel agents have been approved by the Food and Drug Administration for treatment of type 2 diabetes. There is limited experience with these agents in transplant recipients. Use of oral and subcutaneous therapies as well as insulin will be reviewed. As diabetes has a negative impact on patient and graft outcome, the transplant practitioner must be vigilant in screening and managing diabetes after transplantation. JF - Transplantation reviews (Orlando, Fla.) AU - Mannon, Roslyn B AD - Transplantation Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, MD 20892, USA. rozm@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 116 EP - 124 VL - 22 IS - 2 KW - Hypoglycemic Agents KW - 0 KW - Immunosuppressive Agents KW - Insulin KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Tacrolimus -- adverse effects KW - Age Factors KW - Hepatitis C -- complications KW - Risk Factors KW - Humans KW - African Americans KW - Obesity -- complications KW - Immunosuppressive Agents -- adverse effects KW - Hypoglycemic Agents -- therapeutic use KW - Diabetes Mellitus -- etiology KW - Diabetes Mellitus -- chemically induced KW - Insulin -- therapeutic use KW - Insulin -- pharmacology KW - Hypoglycemic Agents -- pharmacology KW - Organ Transplantation -- adverse effects KW - Diabetes Mellitus -- diagnosis KW - Diabetes Mellitus -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69315513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation+reviews+%28Orlando%2C+Fla.%29&rft.atitle=Therapeutic+management+of+posttransplant+diabetes+mellitus.&rft.au=Mannon%2C+Roslyn+B&rft.aulast=Mannon&rft.aufirst=Roslyn&rft.date=2008-04-01&rft.volume=22&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Transplantation+reviews+%28Orlando%2C+Fla.%29&rft.issn=1557-9816&rft_id=info:doi/10.1016%2Fj.trre.2007.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-26 N1 - Date created - 2008-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.trre.2007.12.003 ER - TY - JOUR T1 - Receptor-directed therapy of T-cell leukemias and lymphomas. AN - 69237366; 18569395 AB - T-Cell leukemias and lymphomas represent a less common and heterogeneous group of lymphoid neoplasms. Overall, they respond less well to chemotherapy and have a poorer prognosis than their B-cell counterparts. T-Cell tumors express a number of potential targets for receptor-directed antibody therapy; however, there is no available therapeutic monoclonal antibody for these diseases with comparable activity to that of rituximab in B-cell disorders. Despite this, alemtuzumab, a humanized anti-CD52 monoclonal antibody has demonstrated meaningful anti-tumor activity in a variety of T-cell malignancies. A number of other antibodies, modified antibodies and immunotoxins directed against targets such as CD2, CD4, CD5, CD25, CD30 and CD122 expressed on malignant T-cells are under investigation. The current status of receptor-directed antibody therapy for T-cell leukemia and lymphoma is reviewed. JF - Journal of immunotoxicology AU - Morris, John C AU - Waldmann, Thomas A AU - Janik, John E AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Bethesda, Maryland 20892-1457, USA. jmorris@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 235 EP - 248 VL - 5 IS - 2 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antibodies, Neoplasm KW - Antigens, CD KW - Antineoplastic Agents KW - Receptors, Cell Surface KW - alemtuzumab KW - 3A189DH42V KW - Index Medicus KW - Humans KW - Prognosis KW - Receptors, Cell Surface -- immunology KW - Lymphoma, T-Cell -- diagnosis KW - Leukemia, T-Cell -- drug therapy KW - Leukemia, T-Cell -- diagnosis KW - Lymphoma, T-Cell -- drug therapy KW - Antibodies, Neoplasm -- therapeutic use KW - Receptors, Cell Surface -- antagonists & inhibitors KW - Lymphoma, T-Cell -- immunology KW - Antineoplastic Agents -- therapeutic use KW - Leukemia, T-Cell -- immunology KW - Antigens, CD -- immunology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69237366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Receptor-directed+therapy+of+T-cell+leukemias+and+lymphomas.&rft.au=Morris%2C+John+C%3BWaldmann%2C+Thomas+A%3BJanik%2C+John+E&rft.aulast=Morris&rft.aufirst=John&rft.date=2008-04-01&rft.volume=5&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.1080%2F15476910802129661 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-12 N1 - Date created - 2008-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15476910802129661 ER - TY - JOUR T1 - Intraperitoneal chemotherapy for women with epithelial ovarian cancer. AN - 69167657; 18448554 AB - In 2006, i.p. chemotherapy re-emerged as a controversial topic in debates about the optimal treatment for women with advanced epithelial ovarian cancer. In this paper, we address the rationale behind i.p. chemotherapy, the data supporting its use, the selection of appropriate patients for i.p. chemotherapy, how best to avoid and manage the toxicities observed with i.p. chemotherapy, and directions for future research. JF - The oncologist AU - Trimble, Edward L AU - Thompson, Sharon AU - Christian, Michaele C AU - Minasian, Lori AD - Division of Cancer Treatment and Diagnosis, National Cancer Institute, 6130 Executive Boulevard, Suite 7025, MSC 7436, Bethesda, Maryland 20892-7436, USA. trimblet@ctep.nci.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 403 EP - 409 VL - 13 IS - 4 SN - 1083-7159, 1083-7159 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Quality of Life KW - Patient Selection KW - Infusions, Parenteral -- adverse effects KW - Female KW - Neoplasms, Glandular and Epithelial -- psychology KW - Neoplasms, Glandular and Epithelial -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Ovarian Neoplasms -- psychology KW - Antineoplastic Agents -- therapeutic use KW - Ovarian Neoplasms -- drug therapy KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69167657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Intraperitoneal+chemotherapy+for+women+with+epithelial+ovarian+cancer.&rft.au=Trimble%2C+Edward+L%3BThompson%2C+Sharon%3BChristian%2C+Michaele+C%3BMinasian%2C+Lori&rft.aulast=Trimble&rft.aufirst=Edward&rft.date=2008-04-01&rft.volume=13&rft.issue=4&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/10.1634%2Ftheoncologist.2007-0058 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-17 N1 - Date created - 2008-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2007-0058 ER - TY - JOUR T1 - Ethanol-BDNF interactions: still more questions than answers. AN - 69145075; 18394710 AB - Brain-derived neurotrophic factor (BDNF) has emerged as a regulator of development, plasticity and, recently, addiction. Decreased neurotrophic activity may be involved in ethanol-induced neurodegeneration in the adult brain and in the etiology of alcohol-related neurodevelopmental disorders. This can occur through decreased expression of BDNF or through inability of the receptor to transduce signals in the presence of ethanol. In contrast, recent studies implicate region-specific up-regulation of BDNF and associated signaling pathways in anxiety, addiction and homeostasis after ethanol exposure. Anxiety and depression are precipitating factors for substance abuse and these disorders also involve region-specific changes in BDNF in both pathogenesis and response to pharmacotherapy. Polymorphisms in the genes coding for BDNF and its receptor TrkB are linked to affective, substance abuse and appetitive disorders and therefore may play a role in the development of alcoholism. This review summarizes historical and pre-clinical data on BDNF and TrkB as it relates to ethanol toxicity and addiction. Many unresolved questions about region-specific changes in BDNF expression and the precise role of BDNF in neuropsychiatric disorders and addiction remain to be elucidated. Resolution of these questions will require significant integration of the literature on addiction and comorbid psychiatric disorders that contribute to the development of alcoholism. JF - Pharmacology & therapeutics AU - Davis, Margaret I AD - Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. midavis@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 36 EP - 57 VL - 118 IS - 1 SN - 0163-7258, 0163-7258 KW - Brain-Derived Neurotrophic Factor KW - 0 KW - Central Nervous System Depressants KW - Ethanol KW - 3K9958V90M KW - Receptor, trkB KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Drug Delivery Systems KW - Receptor, trkB -- drug effects KW - Humans KW - Nerve Degeneration -- physiopathology KW - Disease Models, Animal KW - Nerve Degeneration -- chemically induced KW - Alcoholism -- drug therapy KW - Pregnancy KW - Fetal Alcohol Spectrum Disorders -- physiopathology KW - Signal Transduction -- drug effects KW - Receptor, trkB -- metabolism KW - Alcoholism -- physiopathology KW - Female KW - Ethanol -- adverse effects KW - Brain-Derived Neurotrophic Factor -- drug effects KW - Brain-Derived Neurotrophic Factor -- metabolism KW - Central Nervous System Depressants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69145075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Ethanol-BDNF+interactions%3A+still+more+questions+than+answers.&rft.au=Davis%2C+Margaret+I&rft.aulast=Davis&rft.aufirst=Margaret&rft.date=2008-04-01&rft.volume=118&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=01637258&rft_id=info:doi/10.1016%2Fj.pharmthera.2008.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-16 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurosci. 1999 Dec 1;19(23):10575-83 [10575053] Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15239-44 [10611369] Neurotoxicol Teratol. 2000 Jan-Feb;22(1):125-32 [10642121] Hippocampus. 2000;10(1):94-110 [10706221] EMBO J. 2000 Mar 15;19(6):1290-300 [10716929] Brain Res Dev Brain Res. 2000 May 11;121(1):97-107 [10837897] J Clin Psychiatry. 2000 May;61(5):368-72 [10847312] Brain Res Mol Brain Res. 2000 Jun 23;79(1-2):174-9 [10925157] Neurosci Lett. 2000 Sep 15;291(2):121-5 [10978589] Neuron. 2000 Sep;27(3):499-512 [11055433] FASEB J. 2000 Nov;14(14):2303-14 [11053252] J Neurosci. 2001 Jan 15;21(2):434-43 [11160424] J Neurosci Res. 2001 Jan 15;63(2):200-8 [11169630] Nature. 2001 May 3;411(6833):86-9 [11333982] J Biol Chem. 2001 May 25;276(21):18169-77 [11278445] Science. 2001 Jul 20;293(5529):493-8 [11408619] Toxicol Appl Pharmacol. 2001 Aug 15;175(1):10-8 [11509022] Brain Res Mol Brain Res. 2001 Sep 10;93(1):46-55 [11532337] Brain Res Mol Brain Res. 2001 Sep 10;93(1):56-63 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http://dx.doi.org/10.1016/j.pharmthera.2008.01.003 ER - TY - JOUR T1 - Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition. AN - 69143334; 18414063 AB - Bortezomib (Velcade((R))), a proteasome inhibitor, is approved by the FDA for the treatment of multiple myeloma (MM). While effective, its use has been hampered by peripheral neurotoxicity of unexplained etiology. Since proteasome inhibitors alter protein degradation, we speculated that proteins regulating microtubule (MT) stability may be affected after treatment and examined MT polymerization in cells by comparing the distribution of tubulin between polymerized (P) and soluble (S) fractions. We observed increased MT polymerization following treatment of SY5Y and KCNR [neuroblastoma], HCN2, and 8226 [MM] cells, using five proteasome inhibitors; the baseline proportion of total alpha-tubulin in 'P' fractions ranged from approximately 41-68%, and increased to approximately 55-99% after treatment. Increased acetylated alpha-tubulin, a post-translational marker of stabilized MTs, was observed in the neural cell lines HCN1A and HCN2 and this was sustained up to 144 hours after the proteasome inhibitor was removed. Cell cycle analysis of three cell lines after treatment, showed approximately 50-75% increases in the G(2)M phase. Immunofluorescent localization studies of proteasome inhibitor treated cells did not reveal microtubule bundles in contrast to paclitaxel treated, suggesting MT stabilization via a mechanism other than direct drug binding. We examined the levels of microtubule associated proteins and observed a 1.4-3.7 fold increase in the microtubule associated protein MAP2, in HCN2 cells following treatment with proteasome inhibitors. These data provide a plausible explanation for the neurotoxicity observed clinically and raise the possibility that microtubule stabilization contributes to cytotoxicity. JF - Cell cycle (Georgetown, Tex.) AU - Poruchynsky, Marianne S AU - Sackett, Dan L AU - Robey, Robert W AU - Ward, Yvona AU - Annunziata, Christina AU - Fojo, Tito AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 940 EP - 949 VL - 7 IS - 7 KW - Boronic Acids KW - 0 KW - MAP2 protein, human KW - Microtubule-Associated Proteins KW - Protease Inhibitors KW - Pyrazines KW - Tubulin KW - Tubulin Modulators KW - Bortezomib KW - 69G8BD63PP KW - Index Medicus KW - Microtubule-Associated Proteins -- metabolism KW - Humans KW - Cell Line, Tumor KW - Fluorescent Antibody Technique KW - Boronic Acids -- pharmacology KW - Protease Inhibitors -- pharmacology KW - G2 Phase -- drug effects KW - Peripheral Nervous System Diseases -- metabolism KW - Peripheral Nervous System Diseases -- etiology KW - Tubulin Modulators -- pharmacology KW - Pyrazines -- pharmacology KW - Tubulin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69143334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Proteasome+inhibitors+increase+tubulin+polymerization+and+stabilization+in+tissue+culture+cells%3A+a+possible+mechanism+contributing+to+peripheral+neuropathy+and+cellular+toxicity+following+proteasome+inhibition.&rft.au=Poruchynsky%2C+Marianne+S%3BSackett%2C+Dan+L%3BRobey%2C+Robert+W%3BWard%2C+Yvona%3BAnnunziata%2C+Christina%3BFojo%2C+Tito&rft.aulast=Poruchynsky&rft.aufirst=Marianne&rft.date=2008-04-01&rft.volume=7&rft.issue=7&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-16 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The elusive object of desire--interactions of bacteriophages and their hosts. AN - 69119983; 18400552 AB - Bacteria and their viruses (phages) are locked in an evolutionary contest, with each side producing constantly changing mechanisms of attack and defense that are aimed to increase the odds of survival. As a result, phages play central roles in a great variety of genetic processes and increase the rate of evolutionary change of the bacterial host, which could ultimately work to the benefit of the host in a long run. JF - Current opinion in microbiology AU - Nechaev, Sergei AU - Severinov, Konstantin AD - Laboratory of Molecular Carcinogenesis, NIEHS/NIH, Room D434, 111 Alexander Dr, Research Triangle Park, NC 27709, USA. nechaevs@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 186 EP - 193 VL - 11 IS - 2 SN - 1369-5274, 1369-5274 KW - Bacterial Proteins KW - 0 KW - Viral Proteins KW - Index Medicus KW - Viral Proteins -- genetics KW - Gene Expression Regulation, Bacterial KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- metabolism KW - Viral Proteins -- metabolism KW - Evolution, Molecular KW - Bacteria -- genetics KW - Host-Parasite Interactions KW - Bacteriophages -- genetics KW - Bacteria -- virology KW - Bacteriophages -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69119983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+microbiology&rft.atitle=The+elusive+object+of+desire--interactions+of+bacteriophages+and+their+hosts.&rft.au=Cook%2C+Michael+B%3BSigurdson%2C+Alice+J%3BThomas%2C+Cynthia+B%3BGraubard%2C+Barry+I%3BKorde%2C+Larissa%3BGreene%2C+Mark+H%3BJones%2C+Irene+M%3BMcGlynn%2C+Katherine+A&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-08 N1 - Date created - 2008-04-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 2002 Mar;43(6):1565-75 [11952905] Nat Rev Microbiol. 2008 Mar;6(3):181-6 [18157154] J Mol Biol. 2003 Jul 18;330(4):735-48 [12850143] Annu Rev Microbiol. 2003;57:301-22 [14527281] Trends Microbiol. 2003 Oct;11(10):457-61 [14557028] Nat Biotechnol. 2004 Feb;22(2):185-91 [14716317] Proc Natl Acad Sci U S A. 1979 Oct;76(10):4852-6 [388419] J Bacteriol. 1989 Jun;171(6):3553-6 [2656660] FEMS Microbiol Rev. 1995 Aug;17(1-2):109-19 [7669336] Mol Microbiol. 1995 Jul;17(1):85-93 [7476211] Microbiol Mol Biol Rev. 1998 Jun;62(2):275-93 [9618442] Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2192-7 [10051617] J Mol Biol. 1999 Jun 18;289(4):815-26 [10369763] FEBS Lett. 2001 Apr 27;495(3):167-71 [11334885] J Biochem Mol Biol. 2005 Jan 31;38(1):97-103 [15715953] FEMS Microbiol Rev. 2006 May;30(3):321-81 [16594962] PLoS Comput Biol. 2005 Nov;1(6):e60 [16292354] Archaea. 2006 Aug;2(1):59-72 [16877322] Virol J. 2006;3:30 [16716236] Virology. 2006 Oct 25;354(2):240-51 [16887164] Mol Microbiol. 2006 Nov;62(4):1132-43 [17010157] PLoS Biol. 2006 Jul;4(8):e234 [16802857] Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19039-44 [17135349] J Mol Biol. 2007 Feb 16;366(2):420-35 [17187825] J Mol Biol. 2007 Feb 23;366(3):768-78 [17188297] J Mol Biol. 2007 Feb 23;366(3):779-89 [17188711] BMC Bioinformatics. 2007;8:18 [17239253] Science. 2007 Mar 23;315(5819):1709-12 [17379808] BMC Bioinformatics. 2007;8:209 [17577412] PLoS Pathog. 2007 Aug 24;3(8):e119 [17722979] Nature. 2007 Sep 6;449(7158):83-6 [17805294] Nat Rev Microbiol. 2007 Oct;5(10):801-12 [17853907] Curr Opin Microbiol. 2007 Aug;10(4):396-400 [17719266] Genome Res. 2007 Oct;17(10):1486-95 [17785533] J Mol Biol. 2008 Jan 4;375(1):29-35 [18021805] Nature. 2007 Dec 13;450(7172):1079-81 [18059461] J Mol Biol. 2008 Jan 18;375(3):720-34 [18037438] Mol Microbiol. 2008 Jan;67(2):448-57 [18067538] Appl Environ Microbiol. 2008 Jan;74(2):516-25 [18039824] Environ Microbiol. 2008 Jan;10(1):200-7 [17894817] J Bacteriol. 2008 Feb;190(4):1429-35 [18065532] J Bacteriol. 2008 Feb;190(4):1401-12 [18065539] J Bacteriol. 2008 Feb;190(4):1390-400 [18065545] Genome Res. 2008 Feb;18(2):293-7 [18077539] J Mol Biol. 2002 Nov 22;324(2):297-307 [12441108] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mib.2008.02.009 ER - TY - JOUR T1 - Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity. AN - 69118775; 18276636 AB - Replication of the mitochondrial genome by DNA polymerase gamma requires dNTP precursors that are subject to oxidation by reactive oxygen species generated by the mitochondrial respiratory chain. One such oxidation product is 8-oxo-dGTP, which can compete with dTTP for incorporation opposite template adenine to yield A-T to C-G transversions. Recent reports indicate that the ratio of undamaged dGTP to dTTP in mitochondrial dNTP pools from rodent tissues varies from approximately 1:1 to >100:1. Within this wide range, we report here the proportion of 8-oxo-dGTP in the dNTP pool that would be needed to reduce the replication fidelity of human DNA polymerase gamma. When various in vivo mitochondrial dNTP pools reported previously were used here in reactions performed in vitro, 8-oxo-dGTP was readily incorporated opposite template A and the resulting 8-oxo-G-A mismatch was not proofread efficiently by the intrinsic 3' exonuclease activity of pol gamma. At the dNTP ratios reported in rodent tissues, whether highly imbalanced or relatively balanced, the amount of 8-oxo-dGTP needed to reduce fidelity was <1% of dGTP. Moreover, direct measurements reveal that 8-oxo-dGTP is present at such concentrations in the mitochondrial dNTP pools of several rat tissues. The results suggest that oxidized dNTP precursors may contribute to mitochondrial mutagenesis in vivo, which could contribute to mitochondrial dysfunction and disease. JF - Nucleic acids research AU - Pursell, Zachary F AU - McDonald, J Tyson AU - Mathews, Christopher K AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 2174 EP - 2181 VL - 36 IS - 7 KW - DNA, Mitochondrial KW - 0 KW - Deoxyguanine Nucleotides KW - Deoxyribonucleotides KW - 8-oxodeoxyguanosine triphosphate KW - 139307-94-1 KW - deoxyguanosine triphosphate KW - 8C2O37Y44Q KW - DNA polymerase gamma KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Wistar KW - Deoxyribonucleotides -- metabolism KW - Mitochondria -- metabolism KW - Mice KW - Mitochondria, Heart -- metabolism KW - Mitochondria, Heart -- genetics KW - Male KW - Deoxyguanine Nucleotides -- metabolism KW - DNA, Mitochondrial -- chemistry KW - DNA, Mitochondrial -- biosynthesis KW - DNA Replication KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69118775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Trace+amounts+of+8-oxo-dGTP+in+mitochondrial+dNTP+pools+reduce+DNA+polymerase+gamma+replication+fidelity.&rft.au=Pursell%2C+Zachary+F%3BMcDonald%2C+J+Tyson%3BMathews%2C+Christopher+K%3BKunkel%2C+Thomas+A&rft.aulast=Pursell&rft.aufirst=Zachary&rft.date=2008-04-01&rft.volume=36&rft.issue=7&rft.spage=2174&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkn062 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-19 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 1989 Feb 7;28(3):988-95 [2713377] Lancet. 1989 Mar 25;1(8639):642-5 [2564461] Proc Natl Acad Sci U S A. 1990 Jun;87(12):4533-7 [2352934] Nature. 1991 Jan 31;349(6308):431-4 [1992344] Nature. 1992 Jan 16;355(6357):273-5 [1309939] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):11021-5 [1332067] Biochemistry. 1994 Apr 19;33(15):4695-701 [8161527] J Biol Chem. 1995 Jun 16;270(24):14659-65 [7782328] J Biol Chem. 1995 Oct 27;270(43):25942-8 [7592783] Methods Enzymol. 1995;262:217-32 [8594349] Biochem J. 1996 Jan 1;313 ( Pt 1):17-29 [8546679] Biochemistry. 1998 Jul 21;37(29):10529-39 [9671525] Science. 1999 Mar 5;283(5407):1482-8 [10066162] Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):4990-5 [15784738] J Biol Chem. 2005 Jul 1;280(26):24472-80 [15878850] Science. 2005 Jul 15;309(5733):481-4 [16020738] Structure. 2005 Nov;13(11):1653-9 [16271888] Hum Mol Genet. 2006 Jan 15;15(2):363-74 [16368709] Chem Rev. 2006 Feb;106(2):383-405 [16464011] Mutat Res. 2006 Jul 25;599(1-2):11-20 [16490220] Hum Mol Genet. 2006 Oct 1;15(19):2846-55 [16940310] J Biol Chem. 2006 Nov 24;281(47):36241-8 [17005553] Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18586-91 [17124168] Lab Invest. 2007 Apr;87(4):326-35 [17310215] Nat Genet. 2007 Apr;39(4):540-3 [17334366] Nucleic Acids Res. 2007;35(9):3076-86 [17452367] FASEB J. 2007 Aug;21(10):2294-303 [17403938] Hum Mol Genet. 2007 Nov 15;16(22):2729-39 [17725985] Science. 1999 Oct 22;286(5440):774-9 [10531063] J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] J Biol Chem. 2002 May 3;277(18):15807-12 [11856756] J Biol Chem. 2002 May 3;277(18):15225-8 [11897778] Structure. 2003 Jan;11(1):121-7 [12517346] EMBO Rep. 2003 Mar;4(3):269-73 [12634844] J Biol Chem. 2003 Sep 26;278(39):37965-73 [12857738] J Biol Chem. 2004 Apr 23;279(17):17019-26 [14747464] Nature. 2004 May 27;429(6990):417-23 [15164064] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] J Biol Chem. 1988 Mar 25;263(9):4450-9 [2831231] Proc Natl Acad Sci U S A. 1989 Sep;86(17):6469-73 [2671990] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkn062 ER - TY - JOUR T1 - Eukaryotic Y-family polymerases bypass a 3-methyl-2'-deoxyadenosine analog in vitro and methyl methanesulfonate-induced DNA damage in vivo. AN - 69117236; 18281311 AB - N3-methyl-adenine (3MeA) is the major cytotoxic lesion formed in DNA by S(N)2 methylating agents. The lesion presumably blocks progression of cellular replicases because the N3-methyl group hinders interactions between the polymerase and the minor groove of DNA. However, this hypothesis has yet to be rigorously proven, as 3MeA is intrinsically unstable and is converted to an abasic site, which itself is a blocking lesion. To circumvent these problems, we have chemically synthesized a 3-deaza analog of 3MeA (3dMeA) as a stable phosphoramidite and have incorporated the analog into synthetic oligonucleotides that have been used in vitro as templates for DNA replication. As expected, the 3dMeA lesion blocked both human DNA polymerases alpha and delta. In contrast, human polymerases eta, iota and kappa, as well as Saccharomyces cerevisiae poleta were able to bypass the lesion, albeit with varying efficiencies and accuracy. To confirm the physiological relevance of our findings, we show that in S. cerevisiae lacking Mag1-dependent 3MeA repair, poleta (Rad30) contributes to the survival of cells exposed to methyl methanesulfonate (MMS) and in the absence of Mag1, Rad30 and Rev3, human polymerases eta, iota and kappa are capable of restoring MMS-resistance to the normally MMS-sensitive strain. JF - Nucleic acids research AU - Plosky, Brian S AU - Frank, Ekaterina G AU - Berry, David A AU - Vennall, Graham P AU - McDonald, John P AU - Woodgate, Roger AD - Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 2152 EP - 2162 VL - 36 IS - 7 KW - 3-deaza-3-methyladenine KW - 0 KW - Mutagens KW - Saccharomyces cerevisiae Proteins KW - Methyl Methanesulfonate KW - AT5C31J09G KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - REV3 protein, S cerevisiae KW - Rad30 protein KW - DNA Glycosylases KW - EC 3.2.2.- KW - MAG1 protein, S cerevisiae KW - EC 3.2.2.21 KW - Adenine KW - JAC85A2161 KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - Methyl Methanesulfonate -- toxicity KW - Saccharomyces cerevisiae Proteins -- genetics KW - Kinetics KW - Humans KW - DNA Glycosylases -- genetics KW - Mutagens -- toxicity KW - Saccharomyces cerevisiae -- enzymology KW - DNA Replication KW - Gene Deletion KW - Adenine -- chemistry KW - DNA Damage KW - Adenine -- chemical synthesis KW - Adenine -- analogs & derivatives KW - DNA-Directed DNA Polymerase -- genetics KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69117236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Eukaryotic+Y-family+polymerases+bypass+a+3-methyl-2%27-deoxyadenosine+analog+in+vitro+and+methyl+methanesulfonate-induced+DNA+damage+in+vivo.&rft.au=Plosky%2C+Brian+S%3BFrank%2C+Ekaterina+G%3BBerry%2C+David+A%3BVennall%2C+Graham+P%3BMcDonald%2C+John+P%3BWoodgate%2C+Roger&rft.aulast=Plosky&rft.aufirst=Brian&rft.date=2008-04-01&rft.volume=36&rft.issue=7&rft.spage=2152&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/10.1093%2Fnar%2Fgkn058 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-19 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 2000 Apr;182(8):2104-12 [10735851] Science. 1996 Jun 14;272(5268):1646-9 [8658138] Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13573-8 [11106395] Genes Dev. 2001 Jan 15;15(2):158-72 [11157773] J Biol Chem. 2001 Mar 2;276(9):6861-6 [11106652] Mol Cell. 2001 Jul;8(1):7-8 [11515498] Cell. 2001 Oct 5;107(1):91-102 [11595188] Mutat Res. 2001 Dec 19;487(3-4):137-47 [11738940] EMBO J. 2001 Dec 17;20(24):7303-12 [11743006] Curr Genet. 1996 Dec;30(6):461-8 [8939806] Genetics. 1997 Dec;147(4):1557-68 [9409821] J Biol Chem. 1998 Feb 27;273(9):5412-8 [9479003] Proc Natl Acad Sci U S A. 1998 May 12;95(10):5678-83 [9576943] Mol Gen Genet. 1998 Apr;257(6):686-92 [9604893] Mol Cell Biol. 1998 Oct;18(10):5828-37 [9742100] Genes Dev. 1998 Oct 1;12(19):3137-43 [9765213] EMBO J. 1999 Jun 15;18(12):3491-501 [10369688] Genomics. 1999 Aug 15;60(1):20-30 [10458907] Genetics. 2005 Feb;169(2):575-82 [15520252] DNA Repair (Amst). 2006 Feb 3;5(2):210-8 [16263340] J Biol Chem. 2006 Jan 27;281(4):2000-4 [16308320] DNA Repair (Amst). 2007 Jan 4;6(1):3-7 [16979388] Genetics. 2007 Jul;176(3):1431-40 [17483416] J Biol Chem. 2007 Aug 24;282(34):24689-96 [17609217] Mol Cell Biol. 2007 Oct;27(20):7198-205 [17698580] Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15591-8 [17898175] J Biol Chem. 2002 Feb 8;277(6):3894-901 [11711545] Nucleic Acids Res. 2002 Aug 1;30(15):3323-32 [12140316] Mol Cancer Res. 2002 Dec;1(2):103-12 [12496357] DNA Repair (Amst). 2002 Aug 6;1(8):683-96 [12509290] J Exp Med. 2003 Aug 18;198(4):635-43 [12925679] J Biol Chem. 2003 Oct 10;278(41):39951-9 [12882965] Biochemistry. 2004 May 18;43(19):5592-9 [15134433] Nucleic Acids Res. 2004;32(13):3984-94 [15284331] J Natl Cancer Inst. 1979 Jun;62(6):1329-39 [374817] Mutat Res. 1980 Jan;75(1):63-129 [6767183] Proc Natl Acad Sci U S A. 1981 Feb;78(2):856-60 [6940152] Carcinogenesis. 1982;3(1):33-7 [7067035] Mutat Res. 1985 Jun-Jul;150(1-2):77-84 [4000169] J Biol Chem. 1987 Oct 25;262(30):14689-96 [3667598] J Bacteriol. 1989 Oct;171(10):5659-67 [2676986] EMBO J. 1990 Dec;9(13):4563-8 [2265619] J Biol Chem. 1991 Aug 25;266(24):15710-5 [1874728] Nucleic Acids Res. 1995 Sep 25;23(18):3750-5 [7479006] Methods Enzymol. 1995;262:232-56 [8594351] EMBO J. 1996 Feb 15;15(4):945-52 [8631315] Genes Dev. 2000 Jul 1;14(13):1642-50 [10887158] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/nar/gkn058 ER - TY - JOUR T1 - Reliability and validity of a Short Form of the Tobacco Craving Questionnaire. AN - 69109947; 18418787 AB - The Tobacco Craving Questionnaire (TCQ) is a valid and reliable 47-item self-report instrument that assesses tobacco craving in four dimensions: emotionality, expectancy, compulsivity, and purposefulness. For use in research and clinical settings, we constructed a 12-item version of the TCQ by selecting three items from each of the four factors that exhibited optimal within-factor reliability (Cronbach's alpha coefficient) and inter-item correlation. Smokers (N = 196) completed the TCQ-Short Form (TCQ-SF) after overnight tobacco deprivation and on a separate day during ad libitum smoking. Confirmatory factor analyses indicated acceptable model fit for a 4-factor model, with congruence coefficients suggesting high to very high similarity in factor patterns and magnitude of factor loadings between the TCQ and TCQ-SF in both conditions. Scores on each factor were significantly greater after tobacco deprivation than ad libitum smoking, were associated with measures of tobacco withdrawal, and varied with degree of nicotine dependence. Cronbach's alpha coefficients and average inter-item correlations were similar in both conditions and were consistent with reliability values obtained in the initial validation of the TCQ. Test-retest correlation coefficients were also similar to those found in a previous study. These findings suggest that the TCQ-SF is as valid and reliable as the 47-item TCQ in measuring tobacco craving. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Heishman, Stephen J AU - Singleton, Edward G AU - Pickworth, Wallace B AD - Nicotine Psychopharmacology Unit, Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. heishman@nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 643 EP - 651 VL - 10 IS - 4 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - Sensitivity and Specificity KW - Social Perception KW - Reproducibility of Results KW - Self Concept KW - Humans KW - Adult KW - Middle Aged KW - Affect KW - Male KW - Female KW - Surveys and Questionnaires KW - Tobacco Use Disorder -- psychology KW - Smoking -- psychology KW - Tobacco Use Disorder -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69109947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Reliability+and+validity+of+a+Short+Form+of+the+Tobacco+Craving+Questionnaire.&rft.au=Heishman%2C+Stephen+J%3BSingleton%2C+Edward+G%3BPickworth%2C+Wallace+B&rft.aulast=Heishman&rft.aufirst=Stephen&rft.date=2008-04-01&rft.volume=10&rft.issue=4&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/10.1080%2F14622200801908174 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Clin Psychopharmacol. 2000 May;8(2):225-49 [10843306] Addict Behav. 2007 Oct;32(10):2130-9 [17335983] Nicotine Tob Res. 1999 Mar;1(1):45-52 [11072387] Nicotine Tob Res. 2001 Feb;3(1):7-16 [11260806] Addiction. 2001 Oct;96(10):1419-32 [11571061] J Addict Dis. 2001;20(3):67-85 [11681594] Nicotine Tob Res. 2002 Feb;4(1):79-93 [11906684] Addict Behav. 2003 Sep;28(7):1203-18 [12915164] Nicotine Tob Res. 2003 Oct;5(5):645-54 [14577981] Addiction. 2003 Nov;98(11):1537-46 [14616180] Addict Biol. 2003 Dec;8(4):463-72 [14690883] Psychol Addict Behav. 2004 Sep;18(3):284-8 [15482084] Arch Gen Psychiatry. 1986 Mar;43(3):289-94 [3954551] Br J Addict. 1987 Apr;82(4):407-15 [3555575] J Pers Soc Psychol. 1988 Jun;54(6):1063-70 [3397865] West J Nurs Res. 1990 Oct;12(5):672-81 [2238644] Br J Addict. 1991 Sep;86(9):1119-27 [1932883] Health Psychol. 1995 Jul;14(4):301-9 [7556033] Addict Behav. 1996 Mar-Apr;21(2):139-54 [8730517] Tob Control. 1996 Spring;5(1):52-6 [8795860] J Abnorm Psychol. 1997 Feb;106(1):15-25 [9103714] J Abnorm Psychol. 1997 Feb;106(1):104-16 [9103722] Addict Behav. 2005 Jan;30(1):183-6 [15561459] Psychopharmacology (Berl). 2006 Mar;184(3-4):577-88 [16133128] Psychopharmacology (Berl). 2006 Mar;184(3-4):619-27 [16308727] Clin Psychol Rev. 2006 Mar;26(2):196-215 [16352382] J Consult Clin Psychol. 2006 Apr;74(2):286-94 [16649873] Addict Behav. 2006 Jul;31(7):1116-21 [16157458] Nicotine Tob Res. 2006 Oct;8(5):627-38 [17008190] J Subst Abuse Treat. 2006 Dec;31(4):355-64 [17084789] Addiction. 2000 Aug;95 Suppl 2:S177-87 [11002913] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/14622200801908174 ER - TY - JOUR T1 - Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism. AN - 69106335; 18413810 AB - NAG-1 (nonsteroidal anti-inflammatory drug-activated gene), a member of the transforming growth factor-beta superfamily, is involved in many cellular processes, such as inflammation, apoptosis/survival, and tumorigenesis. Vitamin E succinate (VES) is the succinate derivative of alpha-tocopherol and has antitumorigenic activity in a variety of cell culture and animal models. In the current study, the regulation and role of NAG-1 expression in PC-3 human prostate carcinoma cells by VES was examined. VES treatment induced growth arrest and apoptosis as well as an increase in NAG-1 protein and mRNA levels in a time- and concentration-dependent manner. VES treatment induced nuclear translocation and activation of p38 kinase. Pretreatment with p38 kinase inhibitor blocked the VES-induced increase in NAG-1 protein and mRNA levels, whereas an inhibition of protein kinase C, Akt, c-Jun NH(2)-terminal kinase, or MEK activity had no effect on VES-induced NAG-1 levels. Forced expression of constitutively active MKK6, an upstream kinase for p38, induced an increase in NAG-1 promoter activity, whereas p38 kinase inhibitor blocked MKK6-induced increase in NAG-1 promoter activity. VES treatment resulted in >3-fold increase in the half-life of NAG-1 mRNA in a p38 kinase-dependent manner and transient transfection experiment showed that VES stabilizes NAG-1 mRNA through AU-rich elements in 3'-untranslated region of NAG-1 mRNA. The inhibition of NAG-1 expression by small interfering RNA significantly blocked VES-induced poly(ADP-ribose) polymerase cleavage, suggesting that NAG-1 may play an important role in VES-induced apoptosis. These results indicate that VES-induced expression of NAG-1 mRNA/protein is regulated by transcriptional/post-transcriptional mechanism in a p38 kinase-dependent manner and NAG-1 can be chemopreventive/therapeutic target in prostate cancer. JF - Molecular cancer therapeutics AU - Shim, Minsub AU - Eling, Thomas E AD - Eicosanoids Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 961 EP - 971 VL - 7 IS - 4 SN - 1535-7163, 1535-7163 KW - 3' Untranslated Regions KW - 0 KW - Antioxidants KW - Cytokines KW - GDF15 protein, human KW - Growth Differentiation Factor 15 KW - RNA, Messenger KW - Vitamin E KW - 1406-18-4 KW - Luciferases KW - EC 1.13.12.- KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - MAP Kinase Kinase 6 KW - EC 2.7.12.2 KW - MAP2K6 protein, human KW - Index Medicus KW - Transcription, Genetic -- drug effects KW - Blotting, Northern KW - Cell Nucleus -- metabolism KW - Humans KW - RNA, Messenger -- genetics KW - Tumor Cells, Cultured KW - Apoptosis -- drug effects KW - MAP Kinase Kinase 6 -- antagonists & inhibitors KW - Promoter Regions, Genetic -- genetics KW - Fluorescent Antibody Technique KW - Male KW - Genes, jun -- physiology KW - Cell Proliferation -- drug effects KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - MAP Kinase Kinase Kinases -- metabolism KW - Protein Kinase C -- metabolism KW - MAP Kinase Kinase Kinases -- antagonists & inhibitors KW - Blotting, Western KW - Protein Kinase C -- antagonists & inhibitors KW - RNA, Messenger -- metabolism KW - Transfection KW - 3' Untranslated Regions -- genetics KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - MAP Kinase Kinase 6 -- metabolism KW - Protein Transport KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- pathology KW - Cytokines -- genetics KW - Antioxidants -- pharmacology KW - p38 Mitogen-Activated Protein Kinases -- genetics KW - Vitamin E -- pharmacology KW - Cytokines -- metabolism KW - Cytokines -- antagonists & inhibitors KW - Prostatic Neoplasms -- drug therapy KW - Antioxidants -- chemistry KW - p38 Mitogen-Activated Protein Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69106335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Vitamin+E+succinate+induces+NAG-1+expression+in+a+p38+kinase-dependent+mechanism.&rft.au=Shim%2C+Minsub%3BEling%2C+Thomas+E&rft.aulast=Shim&rft.aufirst=Minsub&rft.date=2008-04-01&rft.volume=7&rft.issue=4&rft.spage=961&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/10.1158%2F1535-7163.MCT-07-0470 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-18 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Growth Differ. 1995 Jun;6(6):655-63 [7669719] Nutr Cancer. 1995;24(2):161-9 [8584452] J Biol Chem. 1996 Feb 9;271(6):2886-91 [8621675] Nutr Cancer. 1997;27(1):92-101 [8970189] Oncogene. 1997 Oct;15(18):2169-77 [9393975] J Biol Chem. 1998 Jan 16;273(3):1741-8 [9430721] J Biol Chem. 1999 Jan 1;274(1):264-9 [9867839] Cancer Res. 1999 Feb 15;59(4):953-61 [10029090] J Biol Chem. 2004 Nov 26;279(48):49617-23 [15377673] Mol Cancer Ther. 2005 Jan;4(1):43-50 [15657352] J Natl Cancer Inst. 2005 Mar 2;97(5):396-9 [15741576] J Biol Chem. 2005 May 13;280(19):18636-42 [15757899] Biochem Biophys Res Commun. 2005 Jun 17;331(4):1515-21 [15883045] Surgery. 2002 Jan;131(1):85-91 [11812968] Carcinogenesis. 2002 Mar;23(3):425-34 [11895857] World J Gastroenterol. 2001 Feb;7(1):60-5 [11819734] J Surg Res. 2002 Aug;106(2):292-8 [12175981] Ann Surg Oncol. 2002 Dec;9(10):1023-32 [12464597] Biochem J. 2002 Dec 15;368(Pt 3):705-20 [12206715] J Biol Chem. 2003 Mar 14;278(11):8904-12 [12514175] Cancer Lett. 2003 Mar 20;192(1):19-24 [12637149] Mol Biol Cell. 2003 May;14(5):2071-87 [12802076] Oncogene. 2003 Jun 26;22(26):3998-4006 [12821934] Cancer Res. 2003 Aug 15;63(16):5034-40 [12941831] Wei Sheng Yan Jiu. 2003 Nov;32(6):573-5 [14963907] World J Gastroenterol. 2004 Apr 15;10(8):1110-4 [15069708] Oncogene. 2004 Apr 15;23(17):3080-8 [15048090] Trends Mol Med. 2004 Mar;10(3):125-9 [15102355] J Biol Chem. 2004 Jul 30;279(31):32393-400 [15187092] Science. 1988 Dec 16;242(4885):1570-2 [3144044] J Biol Chem. 1992 Jan 15;267(2):794-803 [1730670] Science. 1995 Feb 3;267(5198):682-5 [7839144] Int J Cancer. 2006 May 15;118(10):2441-7 [16380976] J Biol Chem. 2006 Apr 28;281(17):11819-25 [16520381] Mol Cancer Ther. 2006 May;5(5):1352-61 [16731769] J Pharmacol Exp Ther. 2006 Aug;318(2):899-906 [16714403] J Cell Physiol. 2006 Sep;208(3):566-74 [16741990] Gastroenterology. 2006 Nov;131(5):1553-60 [17101328] Cancer Epidemiol Biomarkers Prev. 1999 Oct;8(10):893-9 [10548318] Inflamm Res. 1999 Oct;48(10):533-8 [10563470] EMBO J. 1999 Dec 1;18(23):6845-54 [10581258] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):109-14 [10618379] Cell Signal. 2000 Jan;12(1):1-13 [10676842] Nutr Cancer. 2000;36(1):90-100 [10798221] J Biol Chem. 2000 Jun 30;275(26):20127-35 [10777512] J Surg Res. 2000 Sep;93(1):163-70 [10945959] FASEB J. 2001 Feb;15(2):403-15 [11156956] Cancer Res. 2001 Feb 15;61(4):1604-10 [11245472] Mol Pharmacol. 2001 Apr;59(4):901-8 [11259636] Cancer Res. 2001 Sep 1;61(17):6569-76 [11522656] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-07-0470 ER - TY - JOUR T1 - Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes. AN - 69105696; 18375820 AB - The ability of the epidermal growth factor receptor inhibitor gefitinib (Iressa) to prevent/treat methylnitrosourea (MNU)-induced mammary cancers and to modulate biomarkers in female Sprague-Dawley rats was examined. Rats were given a single dose of MNU (75 mg/kg body weight) at 50 days of age. In the prevention studies, continual treatment with Iressa at 10, 3, or 1 mg/kg body weight per day beginning 5 days after MNU reduced tumor multiplicity by 93%, 43%, and 20%, respectively. Treatment of rats bearing small palpable cancers with Iressa (10 mg/kg body weight per day) resulted in the complete regression of 70% of the tumors. Short-term treatment of tumor-bearing rats with Iressa caused decreases in cell proliferation and phosphorylated epidermal growth factor receptor and increases in apoptosis. To examine treatment regimens that might decrease the skin toxicity associated with Iressa, both intermittent treatments and combinations of lower doses of Iressa with other effective agents were evaluated. Treatment with Iressa (10 mg/kg body weight per day) continually or intermittently (either "3 weeks on/3 weeks off" or "4 days on/3 days off") reduced cancer multiplicity by 91%, 24%, and 68%, respectively. However, all regimens reduced tumor weights >85%. Finally, combining suboptimal doses of Iressa with suboptimal doses of vorozole (an aromatase inhibitor) or targretin (a retinoid X receptor agonist) yielded greater chemopreventive efficacy than any of these agents given alone. JF - Molecular cancer therapeutics AU - Lubet, Ronald A AU - Szabo, Eva AU - Christov, Konstantin AU - Bode, Ann M AU - Ericson, Marna E AU - Steele, Vernon E AU - Juliana, M Margaret AU - Grubbs, Clinton J AD - National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA. lubetr@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 972 EP - 979 VL - 7 IS - 4 SN - 1535-7163, 1535-7163 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Quinazolines KW - Tetrahydronaphthalenes KW - Triazoles KW - vorozole KW - 1E2S9YXV2A KW - Methylnitrosourea KW - 684-93-5 KW - bexarotene KW - A61RXM4375 KW - Egfr protein, rat KW - EC 2.7.10.1 KW - Receptor, Epidermal Growth Factor KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Drug Screening Assays, Antitumor KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Receptor, Epidermal Growth Factor -- metabolism KW - Dose-Response Relationship, Drug KW - Tetrahydronaphthalenes -- administration & dosage KW - Phosphorylation -- drug effects KW - Rats KW - Drug Therapy, Combination KW - Quinazolines -- administration & dosage KW - Rats, Sprague-Dawley KW - Apoptosis -- drug effects KW - Female KW - Immunoenzyme Techniques KW - Triazoles -- administration & dosage KW - Biomarkers, Tumor -- metabolism KW - Mammary Neoplasms, Experimental -- chemically induced KW - Mammary Neoplasms, Experimental -- prevention & control KW - Mammary Neoplasms, Experimental -- metabolism KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69105696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Effects+of+gefitinib+%28Iressa%29+on+mammary+cancers%3A+preventive+studies+with+varied+dosages%2C+combinations+with+vorozole+or+targretin%2C+and+biomarker+changes.&rft.au=Lubet%2C+Ronald+A%3BSzabo%2C+Eva%3BChristov%2C+Konstantin%3BBode%2C+Ann+M%3BEricson%2C+Marna+E%3BSteele%2C+Vernon+E%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2008-04-01&rft.volume=7&rft.issue=4&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/10.1158%2F1535-7163.MCT-07-2141 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-18 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-07-2141 ER - TY - JOUR T1 - Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud. AN - 69103864; 18410737 AB - Sonic hedgehog (Shh), which regulates proliferation in many contexts, functions as a limb morphogen to specify a distinct pattern of digits. How Shh's effects on cell number relate to its role in specifying digit identity is unclear. Deleting the mouse Shh gene at different times using a conditional Cre line, we find that Shh functions to control limb development in two phases: a very transient, early patterning phase regulating digit identity, and an extended growth-promoting phase during which the digit precursor mesenchyme expands and becomes recruited into condensing digit primordia. Our analysis reveals an unexpected alternating anterior-posterior sequence of normal mammalian digit formation. The progressive loss of digits upon successively earlier Shh removal mirrors this alternating sequence and highlights Shh's role in cell expansion to produce the normal digit complement. JF - Developmental cell AU - Zhu, Jianjian AU - Nakamura, Eiichiro AU - Nguyen, Minh-Thanh AU - Bao, Xiaozhong AU - Akiyama, Haruhiko AU - Mackem, Susan AD - Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 624 EP - 632 VL - 14 IS - 4 KW - Hedgehog Proteins KW - 0 KW - Shh protein, mouse KW - Tamoxifen KW - 094ZI81Y45 KW - Index Medicus KW - Phenotype KW - Body Patterning KW - Animals KW - Tamoxifen -- adverse effects KW - Genes, Reporter KW - Mice KW - Mice, Transgenic KW - Gene Expression Regulation, Developmental KW - Limb Buds -- drug effects KW - Embryo, Mammalian -- physiology KW - Hedgehog Proteins -- metabolism KW - Extremities -- embryology KW - Limb Buds -- physiology KW - Hedgehog Proteins -- genetics KW - Morphogenesis KW - Embryo, Mammalian -- anatomy & histology KW - Extremities -- growth & development KW - Limb Buds -- anatomy & histology KW - Extremities -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69103864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Comprehensive+Breast+Cancer+Signaling+Network+Analysis.&rft.au=Pierobon%2C+Mariaelena%3BCalvert%2C+Valerie+S%3BGaldi%2C+Francesca%3BDeng%2C+Jahnhong%3BWulfkuhle%2C+Julia%3BSignore%2C+Michele%3BBelluco%2C+Claudio%3BMammano%2C+Enzo%3BZavagno%2C+Giorgio%3BNitti%2C+Donato%3BLiotta%2C+Lance%3BPetricoin+III%2C+Emanuel+F.&rft.aulast=Pierobon&rft.aufirst=Mariaelena&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-19 N1 - Date created - 2008-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.devcel.2008.01.008 ER - TY - JOUR T1 - NIEHS extramural global environmental health portfolio: opportunities for collaboration. AN - 69102273; 18414621 AB - Global environmental health has emerged as a critical topic for environmental health researchers and practitioners. Estimates of the environmental contribution of total worldwide disease burden range from 25 to 33%. We reviewed grants funded by the National Institute of Environmental Health Sciences (NIEHS) during 2005-2007 to evaluate the costs and scientific composition of the global environmental health portfolio, with the ultimate aim of strengthening global environmental health research partnerships. We examined NIEHS grant research databases to identify the global environmental health portfolio. In the past 3 fiscal years (2005-2007), the NIEHS funded 57 scientific research projects in 37 countries, at an estimated cost of $30 million. Metals such as arsenic, methylmercury, and lead are the most frequently studied toxic agents, but a wide range of stressors, routes of exposure, and agents are addressed in the portfolio. The portfolio analysis indicates that there is a firm foundation of research activities upon which additional global environmental health partnerships could be encouraged. Current data structures could be strengthened to support more automated analysis of grantee information. JF - Environmental health perspectives AU - Drew, Christina H AU - Barnes, Martha I AU - Phelps, Jerry AU - Van Houten, Bennett AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. drewc@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 421 EP - 425 VL - 116 IS - 4 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Metals KW - Index Medicus KW - partnerships KW - global health KW - science assessment KW - Humans KW - Research Support as Topic KW - Metals -- toxicity KW - Global Health KW - Research -- organization & administration KW - Environmental Pollutants -- toxicity KW - Environmental Exposure -- adverse effects KW - Environmental Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69102273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=NIEHS+extramural+global+environmental+health+portfolio%3A+opportunities+for+collaboration.&rft.au=Drew%2C+Christina+H%3BBarnes%2C+Martha+I%3BPhelps%2C+Jerry%3BVan+Houten%2C+Bennett&rft.aulast=Drew&rft.aufirst=Christina&rft.date=2008-04-01&rft.volume=116&rft.issue=4&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11323 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-11 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 1999 Sep;10(5):573-84 [10468437] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.11323 ER - TY - JOUR T1 - Neuroplasticity in brain reward circuitry following a history of ethanol dependence. AN - 69101397; 18412612 AB - Mitogen-activated and extracellular regulated kinase (MEK) and extracellular signal-regulated protein kinase (ERK) pathways may underlie ethanol-induced neuroplasticity. Here, we used the MEK inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (UO126) to probe the role of MEK/ERK signaling for the cellular response to an acute ethanol challenge in rats with or without a history of ethanol dependence. Ethanol (1.5 g/kg, i.p.) induced expression of the marker genes c-fos and egr-1 in brain regions associated with both rewarding and stressful ethanol actions. Under non-dependent conditions, ethanol-induced c-fos expression was generally not affected by MEK inhibition, with the exception of the medial amygdala (MeA). In contrast, following a history of dependence, a markedly suppressed c-fos response to acute ethanol was found in the medial pre-frontal/orbitofrontal cortex (OFC), nucleus accumbens shell (AcbSh) and paraventricular nucleus (PVN). The suppressed ethanol response in the OFC and AcbSh, key regions involved in ethanol preference and seeking, was restored by pre-treatment with UO126, demonstrating a recruitment of an ERK/MEK-mediated inhibitory regulation in the post-dependent state. Conversely, in brain areas involved in stress responses (MeA and PVN), an MEK/ERK-mediated cellular activation by acute ethanol was lost following a history of dependence. These data reveal region-specific neuroadaptations encompassing the MEK/ERK pathway in ethanol dependence. Recruitment of MEK/ERK-mediated suppression of the ethanol response in the OFC and AcbSh may reflect devaluation of ethanol as a reinforcer, whereas loss of an MEK/ERK-mediated response in the MeA and PVN may reflect tolerance to its aversive actions. These two neuroadaptations could act in concert to facilitate progression into ethanol dependence. JF - The European journal of neuroscience AU - Hansson, Anita C AU - Rimondini, Roberto AU - Neznanova, Olga AU - Sommer, Wolfgang H AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, NIAAA/NIH, Bethesda, MD 20892-1108, USA. anita.hansson@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 1912 EP - 1922 VL - 27 IS - 8 KW - Butadienes KW - 0 KW - Central Nervous System Depressants KW - Early Growth Response Protein 1 KW - Egr1 protein, rat KW - Enzyme Inhibitors KW - Nitriles KW - U 0126 KW - Ethanol KW - 3K9958V90M KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - Index Medicus KW - Early Growth Response Protein 1 -- drug effects KW - Animals KW - Nitriles -- pharmacology KW - Genes, fos -- drug effects KW - Rats KW - Ethanol -- adverse effects KW - MAP Kinase Kinase Kinases -- antagonists & inhibitors KW - In Situ Hybridization KW - Central Nervous System Depressants -- adverse effects KW - Butadienes -- pharmacology KW - Rats, Wistar KW - Enzyme Inhibitors -- pharmacology KW - Immunohistochemistry KW - Male KW - Gene Expression -- drug effects KW - Brain -- physiopathology KW - Reward KW - Brain -- drug effects KW - Neuronal Plasticity -- physiology KW - Alcoholism -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69101397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Neuroplasticity+in+brain+reward+circuitry+following+a+history+of+ethanol+dependence.&rft.au=Hansson%2C+Anita+C%3BRimondini%2C+Roberto%3BNeznanova%2C+Olga%3BSommer%2C+Wolfgang+H%3BHeilig%2C+Markus&rft.aulast=Hansson&rft.aufirst=Anita&rft.date=2008-04-01&rft.volume=27&rft.issue=8&rft.spage=1912&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=1460-9568&rft_id=info:doi/10.1111%2Fj.1460-9568.2008.06159.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-01 N1 - Date created - 2008-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Pharmacol. 2007 Feb;7(1):77-85 [17085074] Trends Neurosci. 2007 Aug;30(8):399-406 [17629579] Brain Struct Funct. 2007 Sep;212(2):149-79 [17717690] Eur J Pharmacol. 2002 Mar 29;439(1-3):53-8 [11937092] Neuron. 2002 May 30;34(5):807-20 [12062026] J Pharmacol Exp Ther. 2002 Aug;302(2):516-24 [12130710] Brain Res. 2002 Sep 6;948(1-2):186-91 [12383974] J Neurosci. 2003 Mar 15;23(6):2371-82 [12657697] J Neurosci. 2003 Apr 1;23(7):3085-93 [12684495] Ann N Y Acad Sci. 2003 Apr;985:185-205 [12724159] Eur J Neurosci. 2003 Apr;17(8):1646-54 [12752382] Physiol Behav. 2003 Jun;79(1):113-20 [12818716] BMC Mol Biol. 2003 May 26;4:6 [12769834] J Neurosci. 2003 Jul 9;23(14):6013-22 [12853419] J Stud Alcohol. 2003 Jul;64(4):445-9 [12921185] Am J Psychiatry. 2003 Oct;160(10):1726-39 [14514480] Synapse. 2004 Jan;51(1):32-58 [14579424] J Neurosci. 2003 Oct 29;23(30):9833-41 [14586012] Psychopharmacology (Berl). 2004 Jan;171(3):306-21 [13680075] Biol Psychiatry. 2008 Jan 15;63(2):139-45 [17585886] Biol Psychiatry. 2008 Feb 1;63(3):256-62 [17719014] Cell Mol Neurobiol. 2008 Feb;28(2):157-72 [18041576] Neurosci Lett. 1999 Sep 10;272(2):95-8 [10507550] J Neurosci. 2000 Mar 1;20(5):1849-57 [10684886] Neuropsychopharmacology. 2000 Jun;22(6):581-94 [10788758] FASEB J. 2000 Oct;14(13):1870-2 [11023970] J Neurosci. 2000 Dec 1;20(23):8701-9 [11102476] Neuroscience. 2001;104(4):1085-97 [11457592] Biol Chem. 2001 Jul;382(7):1077-81 [11530939] Eur J Neurosci. 2001 Jul;14(2):342-52 [11553284] Alcohol Clin Exp Res. 2001 Nov;25(11):1662-72 [11707641] FASEB J. 2002 Jan;16(1):27-35 [11772933] Psychopharmacology (Berl). 2001 Dec;158(4):374-81 [11797058] Pharmacol Biochem Behav. 2002 Mar;71(3):509-15 [11830185] Alcohol Clin Exp Res. 2004 Apr;28(4):588-97 [15100610] Pharmacogenomics J. 2004;4(3):208-18 [15052257] Brain Res Bull. 1981 Jan;6(1):47-61 [7470949] Brain Res. 1990 Jun 18;520(1-2):1-5 [2169950] Annu Rev Neurosci. 1992;15:353-75 [1575447] Brain Res Mol Brain Res. 1994 Jul;24(1-4):185-91 [7968356] Vis Neurosci. 1995 Jan-Feb;12(1):35-50 [7718501] FASEB J. 1995 Jun;9(9):726-35 [7601337] Brain Res. 1995 May 8;679(1):89-98 [7648269] Brain Res. 1995 Sep 18;692(1-2):23-40 [8548308] Mol Reprod Dev. 1995 Dec;42(4):459-67 [8607977] Neuroscience. 1996 Mar;71(1):55-75 [8834392] Mol Psychiatry. 1997 Jan;2(1):32-43 [9154216] Brain Res. 1997 Jun 20;760(1-2):94-101 [9237523] Alcohol Clin Exp Res. 1997 Nov;21(8):1497-507 [9394124] Can J Physiol Pharmacol. 1998 Mar;76(3):294-303 [9673793] Alcohol Clin Exp Res. 1998 Nov;22(8):1646-54 [9835277] Eur J Neurosci. 1999 Jul;11(7):2312-22 [10383620] Brain Res Mol Brain Res. 1999 Aug 25;71(2):313-24 [10521585] Alcohol Clin Exp Res. 2004 Nov;28(11):1676-82 [15547454] Pharmacol Biochem Behav. 2004 Dec;79(4):671-89 [15582675] Neuron. 2005 Mar 3;45(5):647-50 [15748840] Psychopharmacology (Berl). 2005 Apr;178(4):367-80 [15765253] Alcohol Clin Exp Res. 2005 Apr;29(4):672-82 [15834234] Neurosci Biobehav Rev. 2005;29(8):1243-53 [16084591] J Neurosci. 2005 Dec 14;25(50):11757-67 [16354934] Neuroscience. 2005;136(4):1049-71 [16226842] J Neurosci. 2006 Jan 4;26(1):233-40 [16399692] J Neurosci. 2006 May 24;26(21):5673-83 [16723524] J Neurosci. 2006 Aug 2;26(31):8025-39 [16885216] Neuroscience. 2006 Sep 29;142(1):1-20 [16887277] Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15236-41 [17015825] Trends Neurosci. 2006 Dec;29(12):695-703 [17084911] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1460-9568.2008.06159.x ER - TY - JOUR T1 - Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum. AN - 68565108; 18246329 AB - Acute systemic administration of salvinorin A, a naturally occurring kappa-opioid receptor (KOPr) agonist, decreases locomotion and striatal dopamine (DA) overflow. Conventional and quantitative microdialysis techniques were used to determine whether salvinorin A infusion into the dorsal striatum (DSTR) decreases DA overflow by altering DA uptake or release. The influence of repeated salvinorin A administration on basal DA dynamics and cocaine-evoked alterations in DA overflow and locomotion was also assessed. Salvinorin A was administered via the dialysis probe (0; 20-200 nM) or via intraperitoneal (i.p.) injection (1.0 or 3.2 mg/kg per day x 5 days). The effects of a challenge dose of cocaine were examined 48 h after repeated salvinorin treatment. Retrodialysis of salvinorin A produced a dose-related, KOPr antagonist reversible, decrease in DA levels. Extracellular DA levels were decreased whereas DA extraction fraction, which provides an estimate of DA uptake, was unaltered. In contrast to its acute administration, repeated salvinorin A administration did not modify dialysate DA levels. Similarly, neither basal extracellular DA levels nor DA uptake was altered. Unlike synthetic KOPr agonists, prior repeated administration of salvinorin A did not attenuate the locomotor activating effects of an acute cocaine (20 mg/kg, i.p.) challenge. However, cocaine-evoked DA overflow was enhanced. These data demonstrate that acute, but not repeated, salvinorin A administration decreases mesostriatal neurotransmission and that activation of DSTR KOPr is sufficient for this effect. Differences in the interaction of salvinorin and synthetic KOPr agonists with cocaine suggest that the pharmacology of these agents may differ. JF - Psychopharmacology AU - Gehrke, Brenda J AU - Chefer, Vladimir I AU - Shippenberg, Toni S AD - Integrative Neuroscience Section, NIH/NIDA Intramural Research Program, Baltimore, MD 21224, USA. gehrkeb@nida.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 509 EP - 517 VL - 197 IS - 3 SN - 0033-3158, 0033-3158 KW - Diterpenes, Clerodane KW - 0 KW - Hallucinogens KW - Receptors, Opioid, kappa KW - Cocaine KW - I5Y540LHVR KW - salvinorin A KW - T56W91NG6J KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Microdialysis KW - Injections, Intraperitoneal KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Drug Administration Schedule KW - Brain Mapping KW - Cocaine -- pharmacology KW - Male KW - Receptors, Opioid, kappa -- agonists KW - Hallucinogens -- pharmacology KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Motor Activity -- drug effects KW - Corpus Striatum -- pathology KW - Diterpenes, Clerodane -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68565108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Effects+of+acute+and+repeated+administration+of+salvinorin+A+on+dopamine+function+in+the+rat+dorsal+striatum.&rft.au=Gehrke%2C+Brenda+J%3BChefer%2C+Vladimir+I%3BShippenberg%2C+Toni+S&rft.aulast=Gehrke&rft.aufirst=Brenda&rft.date=2008-04-01&rft.volume=197&rft.issue=3&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-007-1067-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-29 N1 - Date created - 2008-03-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2003 Apr 1;23(7):3076-84 [12684494] Ann Ist Super Sanita. 2006;42(4):477-84 [17361073] Science. 1986 Aug 15;233(4765):774-6 [3016896] Brain Res. 1987 Dec 8;436(1):169-72 [2961413] Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8 [2899326] Synapse. 1991 Sep;9(1):60-5 [1796352] Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2046-50 [1347943] Arch Int Pharmacodyn Ther. 1992 Mar-Apr;316:30-42 [1326932] Res Commun Chem Pathol Pharmacol. 1992 Nov;78(2):193-210 [1282270] J Pharmacol Exp Ther. 1993 Apr;265(1):53-9 [8386244] Anal Chem. 1993 Apr 15;65(8):1017-22 [8494171] J Neurochem. 1993 Nov;61(5):1634-9 [8228982] J Pharmacol Exp Ther. 1994 Feb;268(2):595-9 [8113970] J Ethnopharmacol. 1994 Jun;43(1):53-6 [7526076] J Psychoactive Drugs. 1994 Jul-Sep;26(3):277-83 [7844657] Brain Res. 1995 May 29;681(1-2):147-52 [7552272] Psychopharmacology (Berl). 1995 Aug;120(4):392-9 [8539319] Synapse. 1998 Nov;30(3):255-62 [9776129] Synapse. 1998 Nov;30(3):275-83 [9776131] Psychopharmacology (Berl). 1999 Jun;144(4):339-46 [10435406] J Pharmacol Exp Ther. 1999 Sep;290(3):1307-15 [10454508] J Pharmacol Exp Ther. 2005 Jan;312(1):220-30 [15383632] Psychopharmacology (Berl). 2005 May;179(3):551-8 [15682306] J Neurosci. 2005 May 18;25(20):5029-37 [15901784] J Pharmacol Exp Ther. 2006 Jan;316(1):440-7 [16223871] Eur J Neurosci. 2006 Jan;23(1):229-38 [16420432] J Neurosci. 2006 Mar 8;26(10):2788-97 [16525058] J Neurosci Res. 2006 Aug 1;84(2):450-9 [16676328] Psychopharmacology (Berl). 2000 Jul;151(1):85-90 [10958121] J Neurosci. 2000 Dec 15;20(24):9333-40 [11125013] Synapse. 2001 Mar 15;39(4):343-50 [11169785] Behav Pharmacol. 2001 Jul;12(4):237-45 [11548109] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11934-9 [12192085] Trends Pharmacol Sci. 2003 Mar;24(3):107-9 [12628350] J Pharmacol Exp Ther. 2007 Feb;320(2):801-10 [17060492] J Pharmacol Exp Ther. 2004 Mar;308(3):1197-203 [14718611] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00213-007-1067-6 ER - TY - JOUR T1 - Does Ethics Education Influence the Moral Action of Practicing Nurses and Social Workers? AN - 61377908; 200805286 AB - Purpose/methods: This study investigated the relationship between ethics education and training, and the use and usefulness of ethics resources, confidence in moral decisions, and moral action/activism through a survey of practicing nurses and social workers from four United States (US) census regions. Findings: The sample (n = 1215) was primarily Caucasian (83%), female (85%), well educated (57% with a master's degree). no ethics education at all was reported by 14%, of study participants (8% of social workers had no ethics education, versus 23% of nurses), and only 57% of participants had ethics education in their professional educational program. Those with both professional ethics education and in-service or continuing education were more confident in their moral judgments and more likely to use ethics resources and to take moral action. Social workers had more overall education, more ethics education, and higher confidence and moral action scores, and were more likely to use ethics resources than nurses. Conclusion: Ethics education has a significant positive influence on moral confidence, moral action, and use of ethics resources by nurses and social workers. Adapted from the source document. JF - The American Journal of Bioethics AU - Grady, Christine AU - Danis, Marion AU - Soeken, Karen L AU - O'Donnell, Patricia AU - Taylor, Carol AU - Farrar, Adrienne AU - Ulrich, Connie M AD - Department of Clinical Bioethics, Building 10/1C118, The Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 cgrady@cc.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 4 EP - 11 PB - Taylor & Francis, Philadelphia PA VL - 8 IS - 4 SN - 1526-5161, 1526-5161 KW - ethics education, moral action, ethics consultation KW - Professional Ethics KW - Educational Programs KW - Social Workers KW - Nurses KW - Activism KW - Moral Judgment KW - Adult Education KW - article KW - 6150: professional issues in social work KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61377908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Bioethics&rft.atitle=Does+Ethics+Education+Influence+the+Moral+Action+of+Practicing+Nurses+and+Social+Workers%3F&rft.au=Grady%2C+Christine%3BDanis%2C+Marion%3BSoeken%2C+Karen+L%3BO%27Donnell%2C+Patricia%3BTaylor%2C+Carol%3BFarrar%2C+Adrienne%3BUlrich%2C+Connie+M&rft.aulast=Grady&rft.aufirst=Christine&rft.date=2008-04-01&rft.volume=8&rft.issue=4&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265160802166017 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-10-01 N1 - Number of references - 23 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Professional Ethics; Nurses; Social Workers; Educational Programs; Moral Judgment; Adult Education; Activism DO - http://dx.doi.org/10.1080/15265160802166017 ER - TY - JOUR T1 - Disconnected in a connected world: knowledge and understanding of Web 2.0 tools at the University of Pennsylvania Medical Center AN - 57693140; 200805242 AB - This article outlines five Web 2.0 resources and looks at the use of these tools among medical and nursing professionals and students at the Hospital, Medical School, and Nursing School of the University of Pennsylvania. Questionnaires showed that a majority of the individuals surveyed were unfamiliar with Web 2.0 resources. Additional respondents recognized the tools but did not use them in a medical or nursing context, with a minimal number using any tools to expand their medical or nursing knowledge. A lack of time to set up and use the resources, difficulty of set-up and use, skepticism about the quality of user-generated medical content, and a lack of perceived need for Web 2.0 resources contributed substantially to non-use. The University of Pennsylvania Biomedical Library is responding by increasing the availability of basic, quick, and easy-to-use instructional materials for selected Web 2.0 resources. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Medical Reference Services Quarterly AU - Karpinski, Joanna Lynn AD - National Library of Medicine (NLM), 8600 Rockville Pike, Bethesda, MD 20894 karpinsj@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 53 EP - 72 PB - Haworth Press, Binghamton NY VL - 27 IS - 1 SN - 0276-3869, 0276-3869 KW - Web 2.0, RSS feeds, blogs, podcasts, social tagging, wikis, medical libraries, user-generated content KW - Web 2.0 KW - wikis KW - University of Pennsylvania KW - Medical libraries KW - blogs KW - article KW - 14.11: COMMUNICATIONS AND INFORMATION TECHNOLOGY - NETWORKS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57693140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Reference+Services+Quarterly&rft.atitle=Disconnected+in+a+connected+world%3A+knowledge+and+understanding+of+Web+2.0+tools+at+the+University+of+Pennsylvania+Medical+Center&rft.au=Karpinski%2C+Joanna+Lynn&rft.aulast=Karpinski&rft.aufirst=Joanna&rft.date=2008-04-01&rft.volume=27&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Medical+Reference+Services+Quarterly&rft.issn=02763869&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-09-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - blogs; wikis; Web 2.0; Medical libraries; University of Pennsylvania ER - TY - JOUR T1 - Sequencing and Analyzing the t(1;7) Reciprocal Translocation Breakpoints Associated with a Case of Childhood-onset Schizophrenia/Autistic Disorder AN - 57258149; 200816159 AB - We characterized a t(1;7)(p22;q21) reciprocal translocation in a patient with childhood-onset schizophrenia (COS) and autism using genome mapping and sequencing methods. Based on genomic maps of human chromosome 7 and fluorescence in situ hybridization (FISH) studies, we delimited the region of 7q21 harboring the translocation breakpoint to a ~16-kb interval. A cosmid containing the translocation-associated 1:7 junction on der(1) was isolated and sequenced, revealing the positions on chromosomes 1 and 7, respectively, where the translocation occurred. PCR-based studies enabled the isolation and sequencing of the reciprocal 7:1 junction on der(7). No currently recognized gene on either chromosome appears to be disrupted by the translocation. We further found no evidence for copy-number differences in the genomic regions flanking the translocation junctions in the patient. Our efforts provide sequence-based information about a schizophrenia/autism-associated translocation, and may facilitate future studies investigating the genetic bases of these disorders. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Idol, Jacquelyn R AU - Addington, Anjene M AU - Long, Robert T AU - Rapoport, Judith L AU - Green, Eric D AD - Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 668 EP - 677 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 4 SN - 0162-3257, 0162-3257 KW - Schizophrenia KW - Genetic factors KW - Genetic family histories KW - Autism KW - Childhood onset KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57258149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Sequencing+and+Analyzing+the+t%281%3B7%29+Reciprocal+Translocation+Breakpoints+Associated+with+a+Case+of+Childhood-onset+Schizophrenia%2FAutistic+Disorder&rft.au=Idol%2C+Jacquelyn+R%3BAddington%2C+Anjene+M%3BLong%2C+Robert+T%3BRapoport%2C+Judith+L%3BGreen%2C+Eric+D&rft.aulast=Idol&rft.aufirst=Jacquelyn&rft.date=2008-04-01&rft.volume=38&rft.issue=4&rft.spage=668&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-007-0435-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Childhood onset; Schizophrenia; Autism; Genetic factors; Genetic family histories DO - http://dx.doi.org/10.1007/s10803-007-0435-8 ER - TY - JOUR T1 - The MERITO Study: a multicentre trial of the analgesic effect and tolerability of normal-release oral morphine during 'titration phase' in patients with cancer pain AN - 57245530; 200817156 AB - Adequate and rapid pain control is one of the main goals of cancer pain treatment. The objective of this study was to assess the effect and tolerability of oral normal-release morphine during the initial phase of treatment in patients with moderate-to-severe cancer pain. Consecutive patients naive to strong opioids received normal-release morphine 5 or 10 mg every 4 h during the titration phase (first 5 days), depending on previous analgesic therapy. Pain intensity was assessed using an 11-point Numerical Rating Scale (0-10), and data were recorded in a patient-compiled diary. The primary endpoint was the proportion of time with pain control (a reduction of at least 50% with respect to the baseline pain score) during the titration phase. A total of 159 consecutive patients (102 men; mean age 65 years) with cancer-related pain were enrolled. Pain control was observed for 75% (95% CI 70-80) of the follow-up period in the intent-to-treat population. Overall, 50% and 75% of patients achieved pain control within 8 and 24 h after starting normal-release morphine therapy respectively. The mean pain score was 7.63 points at baseline, and decreased to 2.43 and 1.67 points (both P<0.001) at days 3 and 5 respectively. The most commonly reported adverse events were somnolence (24% of patients), constipation (22%), vomiting (13%), nausea (10%) and confusion (7%). Normal-release morphine results in rapid and satisfactory pain control, and is well tolerated, during the strong-opioid titration phase in patients with moderate-to-severe cancer pain. Adapted from the source document. JF - Palliative Medicine AU - De Conno, F AU - Ripamonti, C AU - Fagnoni, E AU - Brunelli, C AU - Luzzani, M AU - Maltoni, M AU - Arcuri, E AU - Bertetto, O AD - Rehabilitation and Palliative Care Operative Unit, IRCCS Foundation, National Cancer Institute, Milano Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 214 EP - 221 PB - Sage Publications, London UK VL - 22 IS - 3 SN - 0269-2163, 0269-2163 KW - cancer pain KW - morphine KW - normal release KW - oral KW - tolerability KW - Morphine KW - Oral administration KW - Pain KW - Analgesics KW - Side effects KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57245530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Palliative+Medicine&rft.atitle=The+MERITO+Study%3A+a+multicentre+trial+of+the+analgesic+effect+and+tolerability+of+normal-release+oral+morphine+during+%27titration+phase%27+in+patients+with+cancer+pain&rft.au=De+Conno%2C+F%3BRipamonti%2C+C%3BFagnoni%2C+E%3BBrunelli%2C+C%3BLuzzani%2C+M%3BMaltoni%2C+M%3BArcuri%2C+E%3BBertetto%2C+O&rft.aulast=De+Conno&rft.aufirst=F&rft.date=2008-04-01&rft.volume=22&rft.issue=3&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Palliative+Medicine&rft.issn=02692163&rft_id=info:doi/10.1177%2F0269216308088692 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-09-03 N1 - Last updated - 2016-09-27 N1 - CODEN - PAMDE2 N1 - SubjectsTermNotLitGenreText - Morphine; Cancer; Analgesics; Pain; Side effects; Oral administration DO - http://dx.doi.org/10.1177/0269216308088692 ER - TY - JOUR T1 - Enduring couples AN - 37029489; 3803040 JF - Family relations AU - Murry, Velma M AU - Harrell, Amanda W AU - Brody, Gene H AU - Chen, Yi-Fu AU - Simons, Ronald L AU - Black, Angela R AU - Cutrona, Carolyn E AU - Gibbons, Frederick X AU - Waller, Maureen R AU - Porche, Michelle V AU - Purvin, Diane M AU - Bratter, Jenifer L AU - King, Rosalind B AU - Marks, Loren D AU - Hopkins, Katrina AU - Chaney, Cassandra AU - Monroe, Pamela A AU - Nesteruk, Olena AU - Sasser, Diane D AU - Brown, Edna AU - Orbuch, Terri L AU - Bauermeister, Jose A AU - Roy, Kevin M AU - Buckmiller, Nicolle AU - McDowell, April AU - Dush, Claire M. Kamp AU - Taylor, Miles G AU - Kroeger, Rhiannon A AU - Chung, Grace H AU - Tucker, M Belinda AU - Takeuchi, David AU - Bryant, Chalandra M AU - Taylor, Robert Joseph AU - Lincoln, Karen D AU - Chatters, Linda M AU - Jackson, James S AD - University of Georgia ; Iowa State University ; Cornell University ; Wellesley College ; Rice University ; National Institute of Child Health and Human Development, USA ; Louisiana State University ; Montclair State University ; University of Connecticut ; University of Michigan ; New York State Psychiatric Institute ; University of Maryland ; Ohio State University ; University of North Carolina, Chapel Hill ; University of California, Los Angeles ; University of Washington, Seattle ; Pennsylvania State University ; University of Michigan, Ann Arbor Y1 - 2008/04// PY - 2008 DA - Apr 2008 VL - 57 IS - 2 SN - 0197-6664, 0197-6664 KW - Sociology KW - Anthropology KW - Same-sex partnerships KW - Asian-Americans KW - Parenting KW - Household income KW - Marital conflict KW - Interracial marriages KW - Interpersonal relations KW - African-Americans KW - Domestic violence KW - Family relations KW - Low income KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37029489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+relations&rft.atitle=Enduring+couples&rft.au=Murry%2C+Velma+M%3BHarrell%2C+Amanda+W%3BBrody%2C+Gene+H%3BChen%2C+Yi-Fu%3BSimons%2C+Ronald+L%3BBlack%2C+Angela+R%3BCutrona%2C+Carolyn+E%3BGibbons%2C+Frederick+X%3BWaller%2C+Maureen+R%3BPorche%2C+Michelle+V%3BPurvin%2C+Diane+M%3BBratter%2C+Jenifer+L%3BKing%2C+Rosalind+B%3BMarks%2C+Loren+D%3BHopkins%2C+Katrina%3BChaney%2C+Cassandra%3BMonroe%2C+Pamela+A%3BNesteruk%2C+Olena%3BSasser%2C+Diane+D%3BBrown%2C+Edna%3BOrbuch%2C+Terri+L%3BBauermeister%2C+Jose+A%3BRoy%2C+Kevin+M%3BBuckmiller%2C+Nicolle%3BMcDowell%2C+April%3BDush%2C+Claire+M.+Kamp%3BTaylor%2C+Miles+G%3BKroeger%2C+Rhiannon+A%3BChung%2C+Grace+H%3BTucker%2C+M+Belinda%3BTakeuchi%2C+David%3BBryant%2C+Chalandra+M%3BTaylor%2C+Robert+Joseph%3BLincoln%2C+Karen+D%3BChatters%2C+Linda+M%3BJackson%2C+James+S&rft.aulast=Murry&rft.aufirst=Velma&rft.date=2008-04-01&rft.volume=57&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Family+relations&rft.issn=01976664&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 11 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6826 7748 6823; 7689 2698 7748 6823; 9183; 6823; 6037 6271; 7553 6271; 3708 13325; 4777 6093; 4783; 1334 1335 4424 961; 635 1656 10555 6091 961 636 4424 ER - TY - JOUR T1 - 'But will it last?': marital instability among interracial and same-race couples AN - 37026752; 3803029 JF - Family relations AU - Bratter, Jenifer L AU - King, Rosalind B AD - Rice University ; National Institute of Child Health and Human Development, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 160 EP - 171 VL - 57 IS - 2 SN - 0197-6664, 0197-6664 KW - Sociology KW - Anthropology KW - Same-sex partnerships KW - Divorce KW - Interethnic relations KW - Interracial marriages KW - Family relations KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37026752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+relations&rft.atitle=%27But+will+it+last%3F%27%3A+marital+instability+among+interracial+and+same-race+couples&rft.au=Bratter%2C+Jenifer+L%3BKing%2C+Rosalind+B&rft.aulast=Bratter&rft.aufirst=Jenifer&rft.date=2008-04-01&rft.volume=57&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Family+relations&rft.issn=01976664&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6643 6093; 3666; 4777 6093; 6826 7748 6823; 4783 ER - TY - JOUR T1 - The distinctive biology of cancer in adolescents and young adults AN - 275165163; 18354417 AB - One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient (host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences. JF - Nature Reviews. Cancer AU - Barr, Ronald AU - Hayes-Lattin, Brandon AU - Thomas, David AU - Ellis, Chad AU - Anderson, Barry Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 288 EP - 98 CY - London PB - Nature Publishing Group VL - 8 IS - 4 SN - 1474175X KW - Medical Sciences--Oncology KW - Humans KW - Adult KW - Adolescent KW - Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/275165163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews.+Cancer&rft.atitle=The+distinctive+biology+of+cancer+in+adolescents+and+young+adults&rft.au=Barr%2C+Ronald%3BHayes-Lattin%2C+Brandon%3BThomas%2C+David%3BEllis%2C+Chad%3BAnderson%2C+Barry&rft.aulast=Barr&rft.aufirst=Ronald&rft.date=2008-04-01&rft.volume=8&rft.issue=4&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews.+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc2349 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Apr 2008 N1 - Last updated - 2014-03-19 DO - http://dx.doi.org/10.1038/nrc2349 ER - TY - JOUR T1 - Automatic assessment of dynamic contrast-enhanced MRI in an ischemic rat hindlimb model: an exploratory study of transplanted multipotent progenitor cells AN - 21067311; 8632284 AB - This study presents computerized automatic image analysis for quantitatively evaluating dynamic contrast-enhanced MRI in an ischemic rat hindlimb model. MRI at 7T was performed on animals in a blinded placebo-controlled experiment comparing multipotent adult progenitor cell-derived progenitor cell (MDPC)-treated, phosphate buffered saline (PBS)-injected, and sham-operated rats. Ischemic and non-ischemic limb regions of interest were automatically segmented from time-series images for detecting changes in perfusion and late enhancement. In correlation analysis of the time-signal intensity histograms, the MDPC-treated limbs correlated well with their corresponding non-ischemic limbs. However, the correlation coefficient of the PBS control group was significantly lower than that of the MDPC-treated and sham-operated groups. In semi-quantitative parametric maps of contrast enhancement, there was no significant difference in hypo-enhanced area between the MDPC and PBS groups at early perfusion-dependent time frames. However, the late-enhancement area was significantly larger in the PBS than the MDPC group. The results of this exploratory study show that MDPC-treated rats could be objectively distinguished from PBS controls. The differences were primarily determined by late contrast enhancement of PBS-treated limbs. These computerized methods appear promising for assessing perfusion and late enhancement in dynamic contrast-enhanced MRI. Published in 2007 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Hsu, Li-Yueh AU - Wragg, Andrew AU - Anderson, Stasia A AU - Balaban, Robert S AU - Boehm, Manfred AU - Arai, Andrew E AD - National Heart Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, araia@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 111 EP - 119 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 21 IS - 2 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Perfusion KW - Limbs KW - Phosphate KW - Magnetic resonance imaging KW - Animal models KW - Image processing KW - N.M.R. KW - Correlation analysis KW - Ischemia KW - Maps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21067311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Automatic+assessment+of+dynamic+contrast-enhanced+MRI+in+an+ischemic+rat+hindlimb+model%3A+an+exploratory+study+of+transplanted+multipotent+progenitor+cells&rft.au=Hsu%2C+Li-Yueh%3BWragg%2C+Andrew%3BAnderson%2C+Stasia+A%3BBalaban%2C+Robert+S%3BBoehm%2C+Manfred%3BArai%2C+Andrew+E&rft.aulast=Hsu&rft.aufirst=Li-Yueh&rft.date=2008-04-01&rft.volume=21&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Limbs; Magnetic resonance imaging; Stem cells; Ischemia; Animal models; Perfusion; Maps; N.M.R.; Image processing; Correlation analysis; Phosphate DO - http://dx.doi.org/10.1002/nbm.1166 ER - TY - JOUR T1 - NIAID resources for developing new therapies for severe viral infections AN - 21025624; 8254153 AB - Severe viral infections, including hemorrhagic fever and encephalitis, occur throughout the world, but are most prevalent in developing areas that are most vulnerable to infectious diseases. Some of these can also infect related species as illustrated by the threatened extinction of gorillas by Ebola infection in west and central Africa. There are no safe and effective treatments available for these serious infections. In addition to the logistical difficulties inherent in developing a drug for infections that are sporadic and occur mainly in the third world, there is the overwhelming barrier of no hope for return on investment to encourage the pharmaceutical industry to address these unmet medical needs. Therefore, the National Institute of Allergy and infectious Disease (NIAID) has developed and supported a variety of programs and resources to provide assistance and lower the barrier for those who undertake these difficult challenges. The primary programs relevant to the development of therapies for severe viral infections are described and three case studies illustrate how they have been used. In addition, contact information for accessing these resources is supplied. JF - Antiviral Research AU - Greenstone, H AU - Spinelli, B AU - Tseng, C AU - Peacock, S AU - Taylor, K AU - Laughlin, C AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States, claughlin@niaid.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 51 EP - 59 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 78 IS - 1 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Hypersensitivity KW - Infectious diseases KW - Antiviral agents KW - Extinction KW - Hemorrhagic fever KW - Pharmaceuticals KW - Infection KW - Encephalitis KW - V 22340:Antiviral Agents KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21025624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=NIAID+resources+for+developing+new+therapies+for+severe+viral+infections&rft.au=Greenstone%2C+H%3BSpinelli%2C+B%3BTseng%2C+C%3BPeacock%2C+S%3BTaylor%2C+K%3BLaughlin%2C+C&rft.aulast=Greenstone&rft.aufirst=H&rft.date=2008-04-01&rft.volume=78&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2007.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Hypersensitivity; Extinction; Antiviral agents; Infectious diseases; Pharmaceuticals; Hemorrhagic fever; Infection; Encephalitis DO - http://dx.doi.org/10.1016/j.antiviral.2007.10.006 ER - TY - JOUR T1 - The Southeast Asian Influenza Clinical Research Network: Development and challenges for a new multilateral research endeavor AN - 21025556; 8254174 AB - The Southeast Asia Influenza Clinical Research Network (SEA ICRN) (www.seaclinicalresearch.org) is a recently developed multilateral, collaborative partnership that aims to advance scientific knowledge and management of human influenza through integrated clinical investigation. The partnership of hospitals and institutions in Indonesia, Thailand, United Kingdom, United States, and Viet Nam was established in late 2005 after agreement on the general principles and mission of the initiative and after securing initial financial support. The establishment of the SEA ICRN was both a response to the re-emergence of the highly pathogenic avian influenza A(H5N1) virus in Southeast Asia in late 2003 and an acknowledgment that clinical trials on emerging infectious diseases require prepared and coordinated research capacity. The objectives of the Network also include building sustainable research capacity in the region, compliance with international standards, and prompt dissemination of information and sharing of samples. The scope of research includes diagnosis, pathogenesis, treatment and prevention of human influenza due to seasonal or novel viruses. The Network has overcome numerous logistical and scientific challenges but has now successfully initiated several clinical trials. The establishment of a clinical research network is a vital part of preparedness and an important element during an initial response phase to a pandemic. JF - Antiviral Research AU - Higgs, E S AU - Hayden, F G AU - Chotpitayasunondh, T AU - Whitworth, J AU - Farrar, J AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, ehiggs@niaid.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 64 EP - 68 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 78 IS - 1 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Influenza KW - Fowl plague KW - International standards KW - pandemics KW - Infectious diseases KW - Clinical trials KW - Hospitals KW - V 22340:Antiviral Agents KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21025556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=The+Southeast+Asian+Influenza+Clinical+Research+Network%3A+Development+and+challenges+for+a+new+multilateral+research+endeavor&rft.au=Higgs%2C+E+S%3BHayden%2C+F+G%3BChotpitayasunondh%2C+T%3BWhitworth%2C+J%3BFarrar%2C+J&rft.aulast=Higgs&rft.aufirst=E&rft.date=2008-04-01&rft.volume=78&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2007.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Influenza; International standards; Fowl plague; pandemics; Infectious diseases; Clinical trials; Hospitals DO - http://dx.doi.org/10.1016/j.antiviral.2007.10.008 ER - TY - JOUR T1 - alpha B-Crystallin Protects Retinal Tissue during Staphylococcus aureus- Induced Endophthalmitis AN - 21013271; 8086181 AB - Bacterial infections of the eye highlight a dilemma that is central to all immune-privileged sites. On the one hand, immune privilege limits inflammation to prevent bystander destruction of normal tissue and loss of vision. On the other hand, bacterial infections require a robust inflammatory response for rapid clearance of the pathogen. We demonstrate that the retina handles this dilemma, in part, by activation of a protective heat shock protein. During Staphylococcus aureus-induced endophthalmitis, the small heat shock protein alpha B-crystallin is upregulated in the retina and prevents apoptosis during immune clearance of the bacteria. In the absence of alpha B-crystallin, mice display increased retinal apoptosis and retinal damage. We found that S. aureus produces a protease capable of cleaving alpha B-crystallin to a form that coincides with increased retinal apoptosis and tissue destruction. We conclude that alpha B-crystallin is important in protecting sensitive retinal tissue during destructive inflammation that occurs during bacterial endophthalmitis. JF - Infection and Immunity AU - Whiston, Emily A AU - Sugi, Norito AU - Kamradt, Merideth C AU - Sack, Coralynn AU - Heimer, Susan R AU - Engelbert, Michael AU - Wawrousek, Eric F AU - Gilmore, Michael S AU - Ksander, Bruce R AU - Gregory, Meredith S AD - The Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts 02114. School of Arts and Sciences, Bridgewater State College, 24 Park Avenue, Bridgewater, Massachusetts 02325. Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, 635 West 165th Street, New York, New York. National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1781 EP - 1790 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 4 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Apoptosis KW - Eye KW - Retina KW - small heat shock proteins KW - Staphylococcus KW - Endophthalmitis KW - Pathogens KW - Infection KW - alpha -Crystallin KW - Immune privilege KW - Inflammation KW - Vision KW - Proteinase KW - Immune clearance KW - Staphylococcus aureus KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21013271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=alpha+B-Crystallin+Protects+Retinal+Tissue+during+Staphylococcus+aureus-+Induced+Endophthalmitis&rft.au=Whiston%2C+Emily+A%3BSugi%2C+Norito%3BKamradt%2C+Merideth+C%3BSack%2C+Coralynn%3BHeimer%2C+Susan+R%3BEngelbert%2C+Michael%3BWawrousek%2C+Eric+F%3BGilmore%2C+Michael+S%3BKsander%2C+Bruce+R%3BGregory%2C+Meredith+S&rft.aulast=Whiston&rft.aufirst=Emily&rft.date=2008-04-01&rft.volume=76&rft.issue=4&rft.spage=1781&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Apoptosis; Retina; Eye; small heat shock proteins; Endophthalmitis; Pathogens; Infection; alpha -Crystallin; Inflammation; Immune privilege; Vision; Proteinase; Immune clearance; Staphylococcus; Staphylococcus aureus ER - TY - JOUR T1 - Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease AN - 21012830; 8087962 AB - Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disorder characterized by striking progeroid features. Clinical findings in the skin include scleroderma, alopecia and loss of subcutaneous fat. HGPS is usually caused by a dominant-negative mutation in LMNA, a gene that encodes two major proteins of the inner nuclear lamina: lamin A and lamin C. We have generated tetracycline-inducible transgenic lines that carry a minigene of human LMNA under the control of a tet-operon. Two mouse lines were created: one carrying the wild-type sequence of LMNA and the other carrying the most common HGPS mutation. Targeted expression of the HGPS mutation in keratin-5-expressing tissues led to abnormalities in the skin and teeth, including fibrosis, loss of hypodermal adipocytes, structural defects in the hair follicles and sebaceous glands, and abnormal incisors. The severity of the defects was related to the level of expression of the transgene in different mouse lines. These transgenic mice appear to be good models for studies of the molecular mechanisms of skin abnormalities in HGPS and other related disorders. JF - Journal of Cell Science AU - Sagelius, Hanna AU - Rosengardten, Ylva AU - Hanif, Mubashir AU - Erdos, Michael R AU - Rozell, Bjoern AU - Collins, Francis S AU - Eriksson, Maria AD - Department of Biosciences and Nutrition, Karolinska Institutet, Karolinska University Hospital, Huddinge, Novum, SE-14186 Stockholm, Sweden. Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA. Clinical Research Center, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, SE-14186 Stockholm, Sweden Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 969 EP - 978 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK, [URL:http://www.biologists.com/web/index.html] VL - 121 IS - 7 SN - 0021-9533, 0021-9533 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Teeth KW - Incisors KW - Progeria KW - Molecular modelling KW - Skin KW - Follicles KW - Fibrosis KW - Animal models KW - Lamins KW - Transgenic mice KW - Hair KW - Sebaceous gland KW - Alopecia KW - Adipocytes KW - Scleroderma KW - Mutation KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21012830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Science&rft.atitle=Targeted+transgenic+expression+of+the+mutation+causing+Hutchinson-Gilford+progeria+syndrome+leads+to+proliferative+and+degenerative+epidermal+disease&rft.au=Sagelius%2C+Hanna%3BRosengardten%2C+Ylva%3BHanif%2C+Mubashir%3BErdos%2C+Michael+R%3BRozell%2C+Bjoern%3BCollins%2C+Francis+S%3BEriksson%2C+Maria&rft.aulast=Sagelius&rft.aufirst=Hanna&rft.date=2008-04-01&rft.volume=121&rft.issue=7&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Progeria; Incisors; Teeth; Molecular modelling; Skin; Follicles; Fibrosis; Animal models; Lamins; Transgenic mice; Hair; Sebaceous gland; Adipocytes; Alopecia; Scleroderma; Mutation ER - TY - JOUR T1 - Joint Effects of Adiposity and Physical Activity on Incident Mobility Limitation in Older Adults AN - 20960279; 8225098 AB - OBJECTIVESTo examine joint associations of physical activity and adiposity measures (body mass index (BMI), waist circumference, percentage body fat) with incident mobility limitation. DESIGNProspective observational cohort study. SETTINGMemphis, Tennessee and Pittsburgh, Pennsylvania. PARTICIPANTSTwo thousand nine hundred and eighty-two black and white men and women aged 70 to 79 participating in the Health, Aging and Body Composition (Health ABC) study. MEASUREMENTSMobility limitation was defined as reported difficulty walking one-quarter of a mile or climbing 10 steps during two consecutive semiannual assessments over 6.5 years. Three measures of adiposity were included in this study: BMI, total percentage body fat, and waist circumference. Physical activity was assessed using a modified leisure-time physical activity questionnaire. RESULTSForty-six percent of the cohort developed mobility limitation. White and black men with a high BMI ( greater than or equal to 30kg-m2), high total percentage body fat (>31.3%), or high waist circumference ( greater than or equal to 102cm) had an approximately 60%, 40%, and 40%, respectively, higher risk of incident mobility limitation than those with low adiposity. In women, high adiposity was also associated with a significantly higher mobility limitation risk than in those with low adiposity. Low physical activity (lowest quartile) was associated with a 70% higher risk of mobility limitation in all groups. Persons with high adiposity and low physical activity were at particularly high risk of mobility limitation. People with high adiposity who were physically active had an equally high risk of mobility limitation as inactive people with low adiposity. CONCLUSIONHigh adiposity and low self-reported physical activity predicted the onset of mobility limitation in well-functioning older persons. Preventing weight gain in old age and promoting physical activity in obese and non-obese older persons may therefore be effective strategies to prevent mobility loss and future disability. JF - Journal of the American Geriatrics Society AU - Koster, Annemarie AU - Patel, Kushang V AU - Visser, Marjolein AU - van Eijk, Jacques ThM AU - Kanaya, Alka M AU - de Rekeneire, Nathalie AU - Newman, Anne B AU - Tylavsky, Frances A AU - Kritchevsky, Stephen B AU - Harris, Tamara B AD - From the Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, kostera@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 636 EP - 643 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 56 IS - 4 KW - Physical Education Index; Risk Abstracts KW - Age KW - disabilities KW - Mobility KW - Blacks KW - Body mass KW - Women KW - obesity KW - Health KW - body mass KW - physical activity KW - aging KW - Men KW - Gerontology KW - Exercise KW - Movement KW - USA, Tennessee KW - Waist KW - USA, Pennsylvania KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20960279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Joint+Effects+of+Adiposity+and+Physical+Activity+on+Incident+Mobility+Limitation+in+Older+Adults&rft.au=Koster%2C+Annemarie%3BPatel%2C+Kushang+V%3BVisser%2C+Marjolein%3Bvan+Eijk%2C+Jacques+ThM%3BKanaya%2C+Alka+M%3Bde+Rekeneire%2C+Nathalie%3BNewman%2C+Anne+B%3BTylavsky%2C+Frances+A%3BKritchevsky%2C+Stephen+B%3BHarris%2C+Tamara+B&rft.aulast=Koster&rft.aufirst=Annemarie&rft.date=2008-04-01&rft.volume=56&rft.issue=4&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=1532-5415&rft_id=info:doi/10.1111%2Fj.1532-5415.2007.01632.x LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Movement; Exercise; Body mass; Gerontology; Waist; Blacks; Health; Women; Men; USA, Tennessee; USA, Pennsylvania; Mobility; physical activity; disabilities; aging; obesity; Age; body mass DO - http://dx.doi.org/10.1111/j.1532-5415.2007.01632.x ER - TY - JOUR T1 - Adipogenic Human Adenovirus Ad-36 Induces Commitment, Differentiation, and Lipid Accumulation in Human Adipose-Derived Stem Cells AN - 20894552; 8203924 AB - Human adenovirus Ad-36 is causatively and correlatively linked with animal and human obesity, respectively. Ad-36 enhances differentiation of rodent preadipocytes, but its effect on adipogenesis in humans is unknown. To indirectly assess the role of Ad-36-induced adipogenesis in human obesity, the effect of the virus on commitment, differentiation, and lipid accumulation was investigated in vitro in primary human adipose-derived stem/stromal cells (hASC). Ad-36 infected hASC in a time- and dose-dependent manner. Even in the presence of osteogenic media, Ad-36-infected hASC showed significantly greater lipid accumulation, suggestive of their commitment to the adipocyte lineage. Even in the absence of adipogenic inducers, Ad-36 significantly increased hASC differentiation, as indicated by a time-dependent expression of genes within the adipogenic cascade-CCAAT/Enhancer binding protein- beta , peroxisome proliferator-activated receptor- gamma , and fatty acid-binding protein-and consequentially increased lipid accumulation in a time- and viral dose-dependent manner. Induction of hASC to the adipocyte state by Ad-36 was further supported by increased expression of lipoprotein lipase and the accumulation of its extracellular fraction. hASC from subjects harboring Ad-36 DNA in their adipose tissue due to natural infection had significantly greater ability to differentiate compared with Ad-36 DNA-negative counterparts, which offers a proof of concept. Thus, Ad-36 has the potential to induce adipogenesis in hASC, which may contribute to adiposity induced by the virus. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Pasarica, Magdalena AU - Mashtalir, Nazar AU - McAllister, Emily J AU - Kilroy, Gail E AU - Koska, Juraj AU - Permana, Paska AU - de Courten, Barbora AU - Yu, Minghuan AU - Ravussin, Eric AU - Gimble, Jeffery M AU - Dhurandhar, Nikhil V AD - Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA. Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA. Baker Heart Research Institute, Melbourne, Australia. Wayne State University, Detroit, Michigan, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 969 EP - 978 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 26 IS - 4 SN - 1066-5099, 1066-5099 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Lipoprotein lipase KW - Obesity KW - Peroxisome proliferator-activated receptors KW - stromal cells KW - Lipids KW - Preadipocytes KW - Infection KW - Human adenovirus KW - Enhancers KW - Differentiation KW - Stem cells KW - Adipocytes KW - DNA KW - Adipose tissue KW - adipogenesis KW - W 30940:Products KW - V 22420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20894552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Adipogenic+Human+Adenovirus+Ad-36+Induces+Commitment%2C+Differentiation%2C+and+Lipid+Accumulation+in+Human+Adipose-Derived+Stem+Cells&rft.au=Regino%2C+Celeste+A.S.%3BMilenic%2C+Diane+E%3BWong%2C+Karen+J%3BGarmestani%2C+Kayhan%3BBaidoo%2C+Kwamena%3BWilliams%2C+Mark%3BSeidel%2C+Jurgen%3BGreen%2C+Michael%3BChoyke%2C+Peter+L%3BBrechbiel%2C+Martin+W&rft.aulast=Regino&rft.aufirst=Celeste&rft.date=2008-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Lipoprotein lipase; Obesity; stromal cells; Peroxisome proliferator-activated receptors; Lipids; Preadipocytes; Infection; Differentiation; Enhancers; Stem cells; Adipocytes; DNA; Adipose tissue; adipogenesis; Human adenovirus ER - TY - JOUR T1 - Immunopathological aspects of age-related macular degeneration AN - 20887336; 8311766 AB - Age-related macular degeneration (AMD) represents a leading cause of blindness worldwide. While the clinical and histopathological aspects of AMD are well characterized, its etiology and pathogenesis remain unclear. Recent findings suggest a role for immunologic processes in AMD pathogenesis, including the age-related generation of extracellular deposits inside the Brusch membrane and beneath the retinal pigment epithelium, recruitment of macrophages for clearance of these deposits, complement activation, recruitment of tissue-destructive macrophages, microglial activation and accumulation, and proinflammatory effects of chronic inflammation by Chlamydia pneumoniae. This review discusses the evidence for the role of inflammation in human AMD and in animal models of AMD. JF - Seminars in Immunopathology AU - Patel, Mrinali AU - Chan, Chi-Chao AD - National Eye Institute, National Institutes of Health, 10 Center Drive, 10/10N103, NIH/NEI, Bethesda, MD, 20892-1857, USA, chanc@nei.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 97 EP - 110 PB - Springer VL - 30 IS - 2 SN - 1863-2297, 1863-2297 KW - Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Deposits KW - Etiology KW - Macular degeneration KW - Recruitment KW - Animal models KW - Blindness KW - Inflammation KW - Cell activation KW - retinal pigment epithelium KW - Reviews KW - Complement activation KW - Chlamydophila pneumoniae KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20887336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Immunopathology&rft.atitle=Immunopathological+aspects+of+age-related+macular+degeneration&rft.au=Patel%2C+Mrinali%3BChan%2C+Chi-Chao&rft.aulast=Patel&rft.aufirst=Mrinali&rft.date=2008-04-01&rft.volume=30&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Immunopathology&rft.issn=18632297&rft_id=info:doi/10.1007%2Fs00281-008-0112-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; retinal pigment epithelium; Deposits; Etiology; Macular degeneration; Reviews; Complement activation; Recruitment; Animal models; Blindness; Cell activation; Inflammation; Chlamydophila pneumoniae DO - http://dx.doi.org/10.1007/s00281-008-0112-9 ER - TY - JOUR T1 - Three-Dimensional Imaging of the Highly Bent Architecture of Bdellovibrio bacteriovorus by Using Cryo-Electron Tomography AN - 20866176; 8086569 AB - Bdellovibrio bacteriovorus cells are small deltaproteobacterial cells that feed on other gram-negative bacteria, including human pathogens. Using cryo-electron tomography, we demonstrated that B. bacteriovorus cells are capable of substantial flexibility and local deformation of the outer and inner membranes without loss of cell integrity. These shape changes can occur in less than 2 min, and analysis of the internal architecture of highly bent cells showed that the overall distribution of molecular machines and the nucleoid is similar to that in moderately bent cells. B. bacteriovorus cells appear to contain an extensive internal network of short and long filamentous structures. We propose that rearrangements of these structures, in combination with the unique properties of the cell envelope, may underlie the remarkable ability of B. bacteriovorus cells to find and enter bacterial prey. JF - Journal of Bacteriology AU - Borgnia, Mario J AU - Subramaniam, Sriram AU - Milne, Jacqueline LS AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 2588 EP - 2596 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 7 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Lymphocytes B KW - Cell envelopes KW - Gram-negative bacteria KW - Inner membranes KW - Bdellovibrio bacteriovorus KW - Tomography KW - Nucleoids KW - Pathogens KW - imaging KW - Prey KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20866176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Three-Dimensional+Imaging+of+the+Highly+Bent+Architecture+of+Bdellovibrio+bacteriovorus+by+Using+Cryo-Electron+Tomography&rft.au=Borgnia%2C+Mario+J%3BSubramaniam%2C+Sriram%3BMilne%2C+Jacqueline+LS&rft.aulast=Borgnia&rft.aufirst=Mario&rft.date=2008-04-01&rft.volume=190&rft.issue=7&rft.spage=2588&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Lymphocytes B; Inner membranes; Gram-negative bacteria; Cell envelopes; Tomography; Nucleoids; Pathogens; imaging; Prey; Bdellovibrio bacteriovorus ER - TY - JOUR T1 - Egr1 and Gas6 facilitate the adaptation of HEK-293 cells to serum-free media by conferring enhanced viability and higher growth rates AN - 20866081; 8367338 AB - Animal-derived serum is an essential media supplement for mammalian cells in cell culture. For a number of reasons including cost, regulatory concerns, lot inconsistency, potential contamination with adventitious agents, and down-stream processing it is desirable to eliminate the use of serum. Existing protocols designed to adapt cells to serum-free media (SFM) are time-consuming and provide little insight into how the cells adapt. To better understand the physiological responses associated with serum withdrawal and to expedite the adaptation process, a Human Embryonic Kidney-293 (HEK-293) cell line was propagated in 10% fetal bovine serum (FBS) and was progressively adapted to SFM and analyzed at specific serum levels by oligonucleotide microarrays. Of the differentially expressed genes two, early growth response 1 (egr1) and growth arrest specific 6 (gas6), were selected for further analysis based on their level of differential expression, overall expression patterns, and proposed functionalities. HEK-293 cells, propagated in 10% FBS were transfected with egr1 or gas6 and then adapted to SFM. Results indicated that higher expression of either gene moderately enhanced the ability of both cell lines to adapt to SFM. Egr1 appeared to have a greater impact on adaptability than gas6. Results also indicated that specific protein production was unaltered when the expression of egr1 was increased. Flow cytometric analysis revealed increased expression of egr1 was associated with an increase in the percentage of cells in the G2/M phases. These results indicate that enhanced expression of egr1 or gas6 facilitate adaptation to SFM by improving growth and viability. JF - Biotechnology and Bioengineering AU - Jaluria, Pratik AU - Konstantopoulos, Konstantinos AU - Betenbaugh, Michael AU - Shiloach, Joseph AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Biotechnology Unit, Building 14A, Room 173, Bethesda, Maryland 20892, ljs@helix.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1443 EP - 1452 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 99 IS - 6 SN - 0006-3592, 0006-3592 KW - Biotechnology and Bioengineering Abstracts KW - Growth rate KW - Adaptations KW - Contamination KW - Cell culture KW - Oligonucleotides KW - DNA microarrays KW - Serum levels KW - Flow cytometry KW - Adaptability KW - Mammalian cells KW - Dietary supplements KW - Embryos KW - EGR-1 protein KW - Media (culture) KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20866081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Egr1+and+Gas6+facilitate+the+adaptation+of+HEK-293+cells+to+serum-free+media+by+conferring+enhanced+viability+and+higher+growth+rates&rft.au=Jaluria%2C+Pratik%3BKonstantopoulos%2C+Konstantinos%3BBetenbaugh%2C+Michael%3BShiloach%2C+Joseph&rft.aulast=Jaluria&rft.aufirst=Pratik&rft.date=2008-04-01&rft.volume=99&rft.issue=6&rft.spage=1443&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/10.1002%2Fbit.21707 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Growth rate; Adaptations; Contamination; Cell culture; DNA microarrays; Oligonucleotides; Flow cytometry; Serum levels; Adaptability; Mammalian cells; Dietary supplements; Embryos; EGR-1 protein; Media (culture) DO - http://dx.doi.org/10.1002/bit.21707 ER - TY - JOUR T1 - Observation of microscopic diffusion anisotropy in the spinal cord using double-pulsed gradient spin echo MRI AN - 20858320; 8368756 AB - A double-pulsed gradient spin echo (d-PGSE) filtered MRI sequence is proposed to detect microscopic diffusion anisotropy in heterogeneous specimen. The technique was developed, in particular, to characterize local microscopic anisotropy in specimens that are macroscopically isotropic, such as gray matter. In such samples, diffusion tensor MRI (DTI) produces an isotropic or nearly isotropic diffusion tensor despite the fact that the medium may be anisotropic at a microscopic length scale. Using d-PGSE filtered MRI, microscopic anisotropy was observed in a gray matter phantom consisting of randomly oriented tubes filled with water, as well as in fixed pig spinal cord, within a range of b-values that can be readily achieved on clinical and small animal MR scanners. These findings suggest a potential use for this new contrast mechanism in clinical studies and biological research applications. JF - Magnetic Resonance in Medicine AU - Komlosh, M E AU - Lizak, M J AU - Horkay, F AU - Freidlin, R Z AU - Basser, P J AD - Section on Tissue Biophysics and Biomimetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, komloshm@yahoo.com Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 803 EP - 809 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Anisotropy KW - Spinal cord KW - Magnetic resonance imaging KW - N.M.R. KW - Diffusion KW - Substantia grisea KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20858320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Observation+of+microscopic+diffusion+anisotropy+in+the+spinal+cord+using+double-pulsed+gradient+spin+echo+MRI&rft.au=Komlosh%2C+M+E%3BLizak%2C+M+J%3BHorkay%2C+F%3BFreidlin%2C+R+Z%3BBasser%2C+P+J&rft.aulast=Komlosh&rft.aufirst=M&rft.date=2008-04-01&rft.volume=59&rft.issue=4&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21528 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Anisotropy; Magnetic resonance imaging; Spinal cord; Diffusion; Substantia grisea; N.M.R. DO - http://dx.doi.org/10.1002/mrm.21528 ER - TY - JOUR T1 - Fully automatic, retrospective enhancement of real-time acquired cardiac cine MR images using image-based navigators and respiratory motion-corrected averaging AN - 20857696; 8368752 AB - Real-time imaging may be clinically important in patients with congestive heart failure, arrhythmias, or in pediatric cases. However, real-time imaging typically has compromised spatial and temporal resolution compared with gated, segmented studies. To combine the best features of both types of imaging, a new method is proposed that uses parallel imaging to improve temporal resolution of real-time acquired images at the expense of signal-to-noise ratio (SNR), but then produces an SNR-enhanced cine by means of respiratory motion-corrected averaging of images acquired in real-time over multiple heartbeats while free-breathing. The retrospective processing based on image-based navigators and nonrigid image registration is fully automated. The proposed method was compared with conventional cine images in 21 subjects. The resultant image quality for the proposed method (3.9 - 0.44) was comparable to the conventional cine (4.2 - 0.99) on a 5-point scale (P = not significant [n.s.]). The conventional method exhibited degraded image quality in cases of arrhythmias whereas the proposed method had uniformly good quality. Motion-corrected averaging of real-time acquired cardiac images provides a means of attaining high-quality cine images with many of the benefits of real-time imaging, such as free-breathing acquisition and tolerance to arrhythmias. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Chefd'hotel, Christophe AU - Lorenz, Christine H AU - Mancini, Christine AU - Arai, Andrew E AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 771 EP - 778 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Arrhythmia KW - Pediatrics KW - N.M.R. KW - congestive heart failure KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Fully+automatic%2C+retrospective+enhancement+of+real-time+acquired+cardiac+cine+MR+images+using+image-based+navigators+and+respiratory+motion-corrected+averaging&rft.au=Kellman%2C+Peter%3BChefd%27hotel%2C+Christophe%3BLorenz%2C+Christine+H%3BMancini%2C+Christine%3BArai%2C+Andrew+E%3BMcVeigh%2C+Elliot+R&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2008-04-01&rft.volume=59&rft.issue=4&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21509 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - imaging; Arrhythmia; Pediatrics; N.M.R.; congestive heart failure DO - http://dx.doi.org/10.1002/mrm.21509 ER - TY - JOUR T1 - Pittfalls of MRI measurement of white matter perfusion based on arterial spin labeling AN - 20857094; 8368754 AB - Although arterial spin labeling (ASL) MRI has been successfully applied to measure gray matter (GM) perfusion in vivo, accurate detection of white matter (WM) perfusion has proven difficult. Reported literature values are not consistent with each other or with perfusion measured with other modalities. In this work, the cause of these inconsistencies is investigated. The results suggest that WM perfusion values are substantially affected by the limited image resolution and by signal losses caused by the long transit times in WM, which significantly affect the label. From gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) bolus-tracking experiments (N = 6), it is estimated that the transit time can be several seconds long in deep WM. Furthermore, simulations show that even at a spatial resolution of 7 l voxel size, contamination by the GM signals can exceed 40% of the actual WM signal. From 10-min long flow-sensitive alternating inversion recovery ASL (FAIR-ASL) measurements at 3T in normal subjects (N = 7), using highly sensitive detectors, it is shown that single-voxel (7 l) deep WM perfusion values have an signal-to-noise ratio (SNR) less than 1. The poor sensitivity and heterogeneous transit time limit the applicability of ASL for measurement of perfusion in WM. JF - Magnetic Resonance in Medicine AU - van Gelderen, P AU - de Zwart, J A AU - Duyn, J H AD - Advanced MRI, Laboratory of Functional and Molecular Imaging (LFMI), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, gelderen@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 788 EP - 795 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Perfusion KW - Contamination KW - Inversion KW - Gadolinium KW - Magnetic resonance imaging KW - Image processing KW - Substantia alba KW - spatial discrimination KW - N.M.R. KW - Substantia grisea KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Pittfalls+of+MRI+measurement+of+white+matter+perfusion+based+on+arterial+spin+labeling&rft.au=van+Gelderen%2C+P%3Bde+Zwart%2C+J+A%3BDuyn%2C+J+H&rft.aulast=van+Gelderen&rft.aufirst=P&rft.date=2008-04-01&rft.volume=59&rft.issue=4&rft.spage=788&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21515 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Perfusion; Substantia alba; Magnetic resonance imaging; Gadolinium; Inversion; Substantia grisea; N.M.R.; Contamination; spatial discrimination; Image processing DO - http://dx.doi.org/10.1002/mrm.21515 ER - TY - JOUR T1 - Reducing correlated noise in fMRI data AN - 20856494; 8368774 AB - The sensitivity of functional MRI (fMRI) in detecting neuronal activation is dependent on the relative levels of signal and noise in the time-series data. The temporal noise level within a single voxel is generally substantially higher than the intrinsic NMR (thermal) noise, and the noise is often correlated between voxels. This work introduces and evaluates a method that allows fMRI sensitivity improvement by reduction of these correlated noise sources. The method allows model-free estimation of the correlated noise from brain regions not activated by the functional paradigm using a short (1-2 min) reference scan. A single regressor representing this noise-source estimate is added to the design matrix used in the data analysis. Results obtained from five volunteers show an average t-score improvement of 11.3% and a 24.2% increase in the size of the activated area. JF - Magnetic Resonance in Medicine AU - de Zwart, Jacco A AU - van Gelderen, Peter AU - Fukunaga, Masaki AU - Duyn, Jeff H AD - Advanced MRI Section, Laboratory of Functional and Molecular Imaging (LFMI), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, Maryland, USA, Jacco.deZwart@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 939 EP - 945 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Data processing KW - Functional magnetic resonance imaging KW - N.M.R. KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Reducing+correlated+noise+in+fMRI+data&rft.au=de+Zwart%2C+Jacco+A%3Bvan+Gelderen%2C+Peter%3BFukunaga%2C+Masaki%3BDuyn%2C+Jeff+H&rft.aulast=de+Zwart&rft.aufirst=Jacco&rft.date=2008-04-01&rft.volume=59&rft.issue=4&rft.spage=939&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21507 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Data processing; N.M.R.; Brain mapping DO - http://dx.doi.org/10.1002/mrm.21507 ER - TY - JOUR T1 - Formation of IL-7R alpha super(high) and IL-7R alpha super(low) CD8 T Cells during Infection Is Regulated by the Opposing Functions of GABP alpha and Gfi-1 AN - 20849752; 8200948 AB - IL-7 is essential for the survival of naive and memory T cells, and IL-7 receptor alpha -chain (IL-7R alpha ) expression is dynamically regulated in activated CD8 T cells during acute viral and bacterial infections. Most virus-specific CD8 T cells become IL-7R alpha super(low) and are relatively short-lived, but some escape IL-7R alpha repression (referred to as IL-7R alpha super(high) memory precursor effector cells) and preferentially enter the memory CD8 T cell pool. How antiviral effector CD8 T cells regulate IL-7R alpha expression in an "on and off" fashion remains to be characterized. During lymphocytic choriomeningitis virus infection, we found that opposing actions of the transcription factors GABP alpha (GA binding protein alpha ) and Gfi-1 (growth factor independence 1) control IL-7R alpha expression in effector CD8 T cells. Specifically, GABP alpha was required for IL-7R alpha expression in memory precursor effector cells, and this correlated with hyperacetylation of the Il7ra promoter. In contrast, Gfi-1 was required for stable IL-7R alpha repression in effector CD8 T cells and acted by antagonizing GABP alpha binding and recruiting histone deacetylase 1, which deacetylated the Il7ra promoter. Thus, Il7ra promoter acetylation and activity was dependent on the reciprocal binding of GABP alpha and Gfi-1, and these data provide a biochemical mechanism for the generation of stable IL-7R alpha super(high) and IL-7R alpha super(low) states in virus-specific effector CD8 T cells. JF - Journal of Immunology AU - Chandele, Anmol AU - Joshi, Nikhil S AU - Zhu, Jinfang AU - Paul, William E AU - Leonard, Warren J AU - Kaech, Susan M AD - Department of Immunobiology, Yale Medical School, New Haven, CT 06511. Laboratory of Immunology, National Institute of Allergy and Infectious Diseases and Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 5309 EP - 5319 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 8 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Cell survival KW - Histone deacetylase KW - Interleukin 7 KW - Data processing KW - Immunological memory KW - Memory cells KW - CD8 antigen KW - Infection KW - Effector cells KW - Lymphocytic choriomeningitis virus KW - Acetylation KW - Promoters KW - Transcription factors KW - Lymphocytes T KW - Growth factors KW - V 22350:Immunology KW - J 02320:Cell Biology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20849752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Formation+of+IL-7R+alpha+super%28high%29+and+IL-7R+alpha+super%28low%29+CD8+T+Cells+during+Infection+Is+Regulated+by+the+Opposing+Functions+of+GABP+alpha+and+Gfi-1&rft.au=Chandele%2C+Anmol%3BJoshi%2C+Nikhil+S%3BZhu%2C+Jinfang%3BPaul%2C+William+E%3BLeonard%2C+Warren+J%3BKaech%2C+Susan+M&rft.aulast=Chandele&rft.aufirst=Anmol&rft.date=2008-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Interleukin 7; Histone deacetylase; Data processing; Memory cells; Immunological memory; CD8 antigen; Infection; Effector cells; Promoters; Acetylation; Transcription factors; Lymphocytes T; Growth factors; Lymphocytic choriomeningitis virus ER - TY - JOUR T1 - A Splenic Marginal Zone-Like Peripheral Blood CD27 super(+)B220 super(-) B Cell Population Is Preferentially Depleted in HIV Type 1-Infected Individuals AN - 20849496; 8192124 AB - Peripheral blood CD27 super(+) B cells are reduced in HIV-1-infected individuals. In healthy individuals, the human peripheral blood CD27 super(+) B cell pool consists of two subsets defined by the expression, or lack thereof, of the CD45 isoform B220. We investigated the presence of circulating B220 super(+) and B220 super(-) memory B cells in HIV super(+) individuals and found that the reduction in CD27 super(+) memory B cells occurs primarily among CD27 super(+)B220 super(-) B cells. Studies conducted using healthy controls indicate that CD27 super(+)B220 super(-) B cells have a splenic marginal zone like the immunophenotype IgM super(hi)IgD super(Io)CD21 super(+)CD23 super(-), express TLR9, and proliferate and secrete IgG and IgM in response to B cell-specific ODN. CD27 super(+)B220 super(+) B cells have the immunophenotype IgM super(lo)IgD super(hi)CD21 super(+)CD23 super(+), express activation-induced cytidine deaminase, and proliferate in response to SAC but do not secrete immunoglobulin. The AICD expression, along with CD86 expression, by CD27 super(+)B220 super(+) suggests these cells are of germinal center origin. The preferential depletion of CD27 super(+)B220 super(-) B cells mirrors alterations in spleen morphology and resident B cell populations due to HIV infection reported by other investigators and may play an important role in the defective B cell immunity against T-independent pathogens such as pneumococcus observed in HIV-1-infected individuals. JF - AIDS Research and Human Retroviruses AU - Morrow, M AU - Valentin, A AU - Little, R AU - Yarchoan, R AU - Pavlakis, G N AD - Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, NCI-Frederick, Building 535, Room 210, Frederick, Maryland 21702-1201, USA, pavlakis@ncifcrf.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 621 EP - 633 VL - 24 IS - 4 SN - 0889-2229, 0889-2229 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - CD45 antigen KW - Lymphocytes B KW - CD86 antigen KW - TLR9 protein KW - Memory cells KW - Immunological memory KW - Spleen KW - Peripheral blood KW - Activation-induced cytidine deaminase KW - Pathogens KW - Infection KW - Retrovirus KW - Human immunodeficiency virus KW - Immunoglobulin G KW - Cytology KW - Germinal centers KW - Toll-like receptors KW - Immunoglobulin M KW - B220 antigen KW - V 22360:AIDS and HIV KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20849496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Research+and+Human+Retroviruses&rft.atitle=A+Splenic+Marginal+Zone-Like+Peripheral+Blood+CD27+super%28%2B%29B220+super%28-%29+B+Cell+Population+Is+Preferentially+Depleted+in+HIV+Type+1-Infected+Individuals&rft.au=Morrow%2C+M%3BValentin%2C+A%3BLittle%2C+R%3BYarchoan%2C+R%3BPavlakis%2C+G+N&rft.aulast=Morrow&rft.aufirst=M&rft.date=2008-04-01&rft.volume=24&rft.issue=4&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=AIDS+Research+and+Human+Retroviruses&rft.issn=08892229&rft_id=info:doi/10.1089%2Faid.2007.0186 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - CD45 antigen; Lymphocytes B; TLR9 protein; CD86 antigen; Immunological memory; Memory cells; Spleen; Activation-induced cytidine deaminase; Peripheral blood; Pathogens; Infection; Immunoglobulin G; Cytology; Germinal centers; B220 antigen; Immunoglobulin M; Toll-like receptors; Retrovirus; Human immunodeficiency virus DO - http://dx.doi.org/10.1089/aid.2007.0186 ER - TY - JOUR T1 - A Developmental Perspective on Alcohol and Youths 16 to 20 Years of Age AN - 20847292; 8202852 AB - Late adolescence (ie, 16-20 years of age) is a period characterized by escalation of drinking and alcohol use problems for many and by the onset of an alcohol use disorder for some. This heightened period of vulnerability is a joint consequence of the continuity of risk from earlier developmental stages and the unique neurologic, cognitive, and social changes that occur in late adolescence. We review the normative neurologic, cognitive, and social changes that typically occur in late adolescence, and we discuss the evidence for the impact of these transitions on individual drinking trajectories. We also describe evidence linking alcohol abuse in late adolescence with neurologic damage and social impairments, and we discuss whether these are the bases for the association of adolescent drinking with increased risks of mental health, substance abuse, and social problems in adulthood. Finally, we discuss both the challenges and successes in the treatment and prevention of adolescent drinking problems. JF - Pediatrics AU - Brown, Sandra A AU - McGue, Matthew AU - Maggs, Jennifer AU - Schulenberg, John AU - Hingson, Ralph AU - Swartzwelder, Scott AU - Martin, Christopher AU - Chung, Tammy AU - Tapert, Susan F AU - Sher, Kenneth AU - Winters, Ken C AU - Lowman, Cherry AU - Murphy, Stacia AD - Departments of Psychology. Psychiatry, University of California, San Diego, California. Departments of Psychology. Psychiatry, University of Minnesota, Minneapolis, Minnesota. Department of Human Development and Family Studies, Pennsylvania State University, University Park, Pennsylvania. Institute for Social Research, University of Michigan, Ann Arbor, Michigan. National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland. Department of Psychology, Duke University, Durham, North Carolina. Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Department of Psychological Studies, University of Missouri, Columbia, Missouri. National Council on Alcoholism and Drug Abuse, St Louis, Missouri Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - S290 EP - S310 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - s4 SN - 0031-4005, 0031-4005 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - developmental stages KW - substance abuse KW - prevention KW - Adolescents KW - Alcohol KW - Cognitive ability KW - Reviews KW - Neurotoxicity KW - vulnerability KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20847292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=A+Developmental+Perspective+on+Alcohol+and+Youths+16+to+20+Years+of+Age&rft.au=Brown%2C+Sandra+A%3BMcGue%2C+Matthew%3BMaggs%2C+Jennifer%3BSchulenberg%2C+John%3BHingson%2C+Ralph%3BSwartzwelder%2C+Scott%3BMartin%2C+Christopher%3BChung%2C+Tammy%3BTapert%2C+Susan+F%3BSher%2C+Kenneth%3BWinters%2C+Ken+C%3BLowman%2C+Cherry%3BMurphy%2C+Stacia&rft.aulast=Brown&rft.aufirst=Sandra&rft.date=2008-04-01&rft.volume=121&rft.issue=s4&rft.spage=S290&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Alcohol; Adolescents; Cognitive ability; Neurotoxicity; Age; Reviews; prevention; vulnerability; substance abuse; developmental stages ER - TY - JOUR T1 - Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells AN - 20843123; 8088157 AB - Class B scavenger receptors (SR-Bs) bind lipoproteins and play an important role in lipid metabolism. Most recently, SR-B type I (SR-BI) and its splicing variant SR-BII have been found to mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells. In this study, we demonstrate that SR-BI is a key host factor required for hepatitis C virus (HCV) uptake and cross-presentation by human dendritic cells (DCs). Whereas monocytes and T and B cells were characterized by very low or undetectable SR-BI expression levels, human DCs demonstrated a high level of cell surface expression of SR-BI similar to that of primary human hepatocytes. Antibodies targeting the extracellular loop of SR-BI efficiently inhibited HCV-like particle binding, uptake, and cross-presentation by human DCs. Moreover, human high-density lipoprotein specifically modulated HCV-like particle binding to DCs, indicating an interplay of HCV with the lipid transfer function of SR-BI in DCs. Finally, we demonstrate that anti-SR-BI antibodies inhibit the uptake of cell culture-derived HCV (HCVcc) in DCs. In conclusion, these findings identify a novel function of SR-BI for viral antigen uptake and recognition and may have an important impact on the design of HCV vaccines and immunotherapeutic approaches aiming at the induction of efficient antiviral immune responses. JF - Journal of Virology AU - Barth, Heidi AU - Schnober, Eva K AU - Neumann-Haefelin, Christoph AU - Thumann, Christine AU - Zeisel, Mirjam B AU - Diepolder, Helmut M AU - Hu, Zongyi AU - Liang, TJake AU - Blum, Hubert E AU - Thimme, Robert AU - Lambotin, Melanie AU - Baumert, Thomas F AD - Department of Medicine II, University of Freiburg, Freiburg, Germany. Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Inserm, U748, Strasbourg, France. Faculty of Biology, University of Freiburg, Freiburg, Germany. Universite Louis Pasteur, Strasbourg, France. Department of Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany. Service d'Hepatogastroenterologie, Centre Hospitalier Universitaire Strasbourg, Strasbourg, France Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 3466 EP - 3479 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 82 IS - 7 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Cell surface KW - Lymphocytes B KW - Hepatocytes KW - Antigen presentation KW - Lipid metabolism KW - Dendritic cells KW - Splicing KW - Antibodies KW - Hepatitis C virus KW - Mammalian cells KW - Lipoproteins KW - Vaccines KW - Monocytes KW - scavenger receptors KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20843123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Scavenger+Receptor+Class+B+Is+Required+for+Hepatitis+C+Virus+Uptake+and+Cross-Presentation+by+Human+Dendritic+Cells&rft.au=Barth%2C+Heidi%3BSchnober%2C+Eva+K%3BNeumann-Haefelin%2C+Christoph%3BThumann%2C+Christine%3BZeisel%2C+Mirjam+B%3BDiepolder%2C+Helmut+M%3BHu%2C+Zongyi%3BLiang%2C+TJake%3BBlum%2C+Hubert+E%3BThimme%2C+Robert%3BLambotin%2C+Melanie%3BBaumert%2C+Thomas+F&rft.aulast=Barth&rft.aufirst=Heidi&rft.date=2008-04-01&rft.volume=82&rft.issue=7&rft.spage=3466&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; Hepatocytes; Lymphocytes B; Antigen presentation; Lipid metabolism; Dendritic cells; Antibodies; Splicing; Mammalian cells; Lipoproteins; Monocytes; Vaccines; scavenger receptors; Hepatitis C virus ER - TY - JOUR T1 - Kinases as drug targets in the treatment of bipolar disorder AN - 20778718; 8246074 AB - Bipolar disorder is one of the most severely debilitating of all medical illnesses, and is increasingly recognized as a major public health problem. For many patients with bipolar disorder, current pharmacotherapy is insufficient. Exciting recent data suggest that regulation of signaling molecules may be involved in the pathophysiology of the disorder, and in the mechanisms of action of mood stabilizers and antidepressants. Through our developing understanding of the biochemical targets of effective medications, several potential targets for new therapies have emerged. This short review will focus on two of the most promising such targets: glycogen synthase-3 and protein kinase C. JF - Drug Discovery Today AU - Catapano, LA AU - Manji, H K AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, HHS, Bethesda, MD, USA, manji@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 295 EP - 302 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 13 IS - 7-8 SN - 1359-6446, 1359-6446 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Mood KW - Protein kinase C KW - Antidepressants KW - Bipolar disorder KW - Glycogen KW - Signal transduction KW - Public health KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20778718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Kinases+as+drug+targets+in+the+treatment+of+bipolar+disorder&rft.au=Catapano%2C+LA%3BManji%2C+H+K&rft.aulast=Catapano&rft.aufirst=LA&rft.date=2008-04-01&rft.volume=13&rft.issue=7-8&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2008.02.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Mood; Antidepressants; Bipolar disorder; Glycogen; Public health; Signal transduction DO - http://dx.doi.org/10.1016/j.drudis.2008.02.007 ER - TY - JOUR T1 - Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt AN - 20742267; 9015175 AB - Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt, Salivary and nosocomial transmission are possible. To determine whether human herpesvirus 8 (HHV-8) is associated with schistosomal and hepatitis C virus infections in Egypt, we surveyed 965 rural household participants who had been tested for HHV-8 and schistosomal infection (seroprevalence 14.2% and 68.6%, respectively, among those &15 years of age, and 24.2% and 72.8%, respectively, among those greater than or equal to 15 years of age). Among adults, HHV-8 seropositivity was associated with higher age, lower education, dental treatment, tattoos, >10 lifetime injections, and hepatitis C virus seropositivity. In adjusted analyses, HHV-8 seropositivity was associated with dental treatment among men (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.1-5.2) and hepatitis C virus seropositivity among women (OR 3.3, 95% CI 1.4-7.9). HHV-8 association with antischistosomal antibodies was not significant for men (OR 2.1, 95% CI 0.3-16.4), but marginal for women (OR 1.5, 95% CI 1.0-2.5). Our findings suggest salivary and possible nosocomial HHV-8 transmission in rural Egypt. JF - Emerging Infectious Diseases AU - Mbulaiteye, Sam M AU - Pfeiffer, Ruth M AU - Dolan, Bryan AU - Tsang, Victor CW AU - Noh, John AU - Mikhail, Nabiel NH AU - Abdel-Hamid, Mohamed AU - Hashem, Mohamed AU - Whitby, Denise AU - Strickland, GThomas AU - Goedert, James J AD - National Cancer Institute, Bethesda, Maryland, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 586 EP - 591 PB - U.S. National Center for Infectious Diseases, 1600 Clifton Rd VL - 14 IS - 4 SN - 1080-6040, 1080-6040 KW - Virology & AIDS Abstracts; Risk Abstracts KW - HHV-8 KW - epidemiology KW - transmission KW - Africa KW - cancer KW - schistosomiasis KW - research KW - nosocomial infection KW - Egypt, Arab Rep. KW - Age KW - Human herpesvirus 8 KW - Infection KW - Hepatitis KW - households KW - Education KW - Antibodies KW - Hepatitis C virus KW - tattoos KW - Risk factors KW - infection KW - Tattoos KW - Rural areas KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20742267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Seroprevalence+and+Risk+Factors+for+Human+Herpesvirus+8+Infection%2C+Rural+Egypt&rft.au=Mbulaiteye%2C+Sam+M%3BPfeiffer%2C+Ruth+M%3BDolan%2C+Bryan%3BTsang%2C+Victor+CW%3BNoh%2C+John%3BMikhail%2C+Nabiel+NH%3BAbdel-Hamid%2C+Mohamed%3BHashem%2C+Mohamed%3BWhitby%2C+Denise%3BStrickland%2C+GThomas%3BGoedert%2C+James+J&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2008-04-01&rft.volume=14&rft.issue=4&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/10.3201%2Feid1404.070935 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Antibodies; Age; Risk factors; Tattoos; Infection; nosocomial infection; Hepatitis; Education; households; tattoos; infection; Rural areas; Hepatitis C virus; Human herpesvirus 8; Egypt, Arab Rep. DO - http://dx.doi.org/10.3201/eid1404.070935 ER - TY - JOUR T1 - Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl- 2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H- imidazo[2,1-b][1,3]oxazines, analogues of PA-824 AN - 20739605; 8684901 AB - Nitroimidazoles such as PA-824 and OPC-67683 are currently in clinical development as members of a promising new class of therapeutics for tuberculosis. While the antitubercular activity of these compounds is high, they both suffer from poor water solubility thus complicating development. We determined the single crystal X-ray structure of PA-824 and found a close packing of the nitroimidazoles facilitated by a pseudoaxial conformation of the p-trifluoromethoxybenzyl ether. To attempt to disrupt this tight packing by destabilizing the axial preference of this side chain, we prepared the two diastereomers of the 7-methyl-nitroimidazo-oxazine. Determination of the crystal structure of the 7-(S)-methyl derivative ( 5, cis) revealed that the benzylic side chain remained pseudoaxial while the 7- (R)-methyl derivative ( 6, trans) adopted the desired pseudoequatorial conformation. Both derivatives displayed similar activities against Mycobacterium tuberculosis, but neither showed improved aqueous solubility, suggesting that inherent lattice stability is not likely to be a major factor in limiting solubility. Conformational analysis revealed that all three compounds have similar energetically accessible conformations in solution. Additionally, these results suggest that the nitroreductase that initially recognizes PA-824 is somewhat insensitive to substitutions at the 7-position. JF - Bioorganic and Medicinal Chemistry AU - Li, Xiaojin AU - Manjunatha, Ujjini H AU - Goodwin, Michael B AU - Knox, John E AU - Lipinski, Christopher A AU - Keller, Thomas H AU - Barry, Clifton E AU - Dowd, Cynthia S AD - Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA, cdowd@gwu.edu Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 2256 EP - 2262 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 7 SN - 0968-0896, 0968-0896 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Solubility KW - Packing KW - Crystals KW - Nitroreductase KW - Ionizing radiation KW - Crystal structure KW - nitroimidazoles KW - Tuberculosis KW - Ethers KW - Mycobacterium tuberculosis KW - Conformation KW - Conformational analysis KW - W 30965:Miscellaneous, Reviews KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20739605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis+and+antitubercular+activity+of+7-%28R%29-+and+7-%28S%29-methyl-+2-nitro-6-%28S%29-%284-%28trifluoromethoxy%29benzyloxy%29-6%2C7-dihydro-5H-+imidazo%5B2%2C1-b%5D%5B1%2C3%5Doxazines%2C+analogues+of+PA-824&rft.au=Li%2C+Xiaojin%3BManjunatha%2C+Ujjini+H%3BGoodwin%2C+Michael+B%3BKnox%2C+John+E%3BLipinski%2C+Christopher+A%3BKeller%2C+Thomas+H%3BBarry%2C+Clifton+E%3BDowd%2C+Cynthia+S&rft.aulast=Li&rft.aufirst=Xiaojin&rft.date=2008-04-01&rft.volume=18&rft.issue=7&rft.spage=2256&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2008.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nitroreductase; Solubility; Ionizing radiation; Crystal structure; nitroimidazoles; Tuberculosis; Crystals; Ethers; Packing; Conformational analysis; Conformation; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.bmcl.2008.03.011 ER - TY - JOUR T1 - Early Developmental Processes and the Continuity of Risk for Underage Drinking and Problem Drinking AN - 20728723; 8202850 AB - Developmental pathways to underage drinking emerge before the second decade of life. Many scientists, however, as well as the general public, continue to focus on proximal influences surrounding the initiation of drinking in adolescence, such as social, behavioral, and genetic variables related to availability and ease of acquisition of the drug, social reinforcement for its use, and individual differences in drug responses. In the past 20 years, a considerable body of evidence has accumulated on the early (often much earlier than the time of the first drink) predictors and pathways of youthful alcohol use and abuse. These early developmental influences involve numerous risk, vulnerability, promotive, and protective processes. Some of these factors are not related directly to alcohol use, whereas others involve learning and expectancies about later drug use that are shaped by social experience. The salience of these factors (identifiable in early childhood) for understanding the course and development of adult alcohol and other drug use disorders is evident from the large and growing body of findings on their ability to predict adult clinical outcomes. This review summarizes the evidence on early pathways toward and away from underage drinking, with a particular focus on the risk and protective factors and the mediators and moderators of risk for underage drinking that become evident during the preschool and early school years. It is guided by a developmental perspective on the aggregation of risk and protection and examines the contributions of biological, psychological, and social processes within the context of normal development. Implications of this evidence for policy, intervention, and future research are discussed. JF - Pediatrics AU - Zucker, Robert A AU - Donovan, John E AU - Masten, Ann S AU - Mattson, Margaret E AU - Moss, Howard B AD - Department of Psychiatry. Addiction Research Center, University of Michigan, Ann Arbor, Michigan. Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania. Institute of Child Development, University of Minnesota, Minneapolis, Minnesota. Treatment and Recovery Research Branch, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland. Office of the Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - S252 EP - S272 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - s4 SN - 0031-4005, 0031-4005 KW - Risk Abstracts KW - Alcohol KW - Psychology KW - Children KW - Drug abuse KW - schools KW - intervention KW - Reviews KW - vulnerability KW - Drugs KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20728723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Early+Developmental+Processes+and+the+Continuity+of+Risk+for+Underage+Drinking+and+Problem+Drinking&rft.au=Zucker%2C+Robert+A%3BDonovan%2C+John+E%3BMasten%2C+Ann+S%3BMattson%2C+Margaret+E%3BMoss%2C+Howard+B&rft.aulast=Zucker&rft.aufirst=Robert&rft.date=2008-04-01&rft.volume=121&rft.issue=s4&rft.spage=S252&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Alcohol; Drug abuse; Drugs; schools; Reviews; vulnerability; intervention; Psychology; Children ER - TY - JOUR T1 - Solution NMR Structures of Productive and Non-productive Complexes between the A and B Domains of the Cytoplasmic Subunit of the Mannose Transporter of the Escherichia coli Phosphotransferase System AN - 20692486; 8199733 AB - Solution structures of complexes between the isolated A (IIA super(Man)) and B (IIB super(Man)) domains of the cytoplasmic component of the mannose transporter of Escherichia coli have been solved by NMR. The complex of wild-type IIA super(Man) and IIB super(Man) is a mixture of two species comprising a productive, phosphoryl transfer competent complex and a non-productive complex with the two active site histidines, His-10 of IIA super(Man) and His-175 of IIB super(Man), separated by similar to 25Aa sub(.) Mutation of the active site histidine, His-10, of IIA super(Man) to a glutamate, to mimic phosphorylation, results in the formation of a single productive complex. The apparent equilibrium dissociation constants for the binding of both wild-type and H10E IIA super(Man) to IIB super(Man) are approximately the same (K sub(D) similar to 0.5 mM). The productive complex can readily accommodate a transition state involving a pentacoordinate phosphoryl group with trigonal bipyramidal geometry bonded to the N epsilon 2 atom of His-10 of IIA super(Man) and the N delta 1 atom of His-175 of IIB super(Man) with negligible (<0.2Aa sub()) local backbone conformational changes in the immediate vicinity of the active site. The non-productive complex is related to the productive one by a similar to 90 degree rotation and similar to 37Aa translation of IIB super(Man) relative to IIA super(Man), leaving the active site His-175 of IIB super(Man) fully exposed to solvent in the non-productive complex. The interaction surface on IIA super(Man) for the non-productive complex comprises a subset of residues used in the productive complex and in both cases involves both subunits of IIA super(Man). The selection of the productive complex by IIA super(Man)(H10E) can be attributed to neutralization of the positively charged Arg-172 of IIB super(Man) at the center of the interface. The non-productive IIA super(Man)-IIB super(Man) complex may possibly be relevant to subsequent phosphoryl transfer from His-175 of IIB super(Man) to the incoming sugar located on the transmembrane IIC super(Man)-IID super(Man) complex. JF - Journal of Biological Chemistry AU - Hu, Jun AU - Hu, Kaifeng AU - Williams, David CJr AU - Komlosh, Michal E AU - Cai, Mengli AU - Clore, GMarius AD - Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 11024 EP - 11037 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 16 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Translation KW - Sugar KW - Phosphorylation KW - Mannose KW - Histidine KW - Escherichia coli KW - Solvents KW - N.M.R. KW - Glutamic acid KW - phosphotransferase KW - Mutation KW - J 02330:Biochemistry KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20692486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Solution+NMR+Structures+of+Productive+and+Non-productive+Complexes+between+the+A+and+B+Domains+of+the+Cytoplasmic+Subunit+of+the+Mannose+Transporter+of+the+Escherichia+coli+Phosphotransferase+System&rft.au=Hu%2C+Jun%3BHu%2C+Kaifeng%3BWilliams%2C+David+CJr%3BKomlosh%2C+Michal+E%3BCai%2C+Mengli%3BClore%2C+GMarius&rft.aulast=Hu&rft.aufirst=Jun&rft.date=2008-04-01&rft.volume=283&rft.issue=16&rft.spage=11024&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sugar; Translation; Phosphorylation; Histidine; Mannose; Solvents; N.M.R.; phosphotransferase; Glutamic acid; Mutation; Escherichia coli ER - TY - JOUR T1 - Hepatitis B and C virus infection and the risk of biliary tract cancer: A population-based study in China AN - 20682346; 8080083 AB - Emerging data suggest that chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections may also play a role in extrahepatic bile duct cancers. To test the HBV hypothesis, we examined the relationship of HBV/HCV infection with risks of biliary tract cancer and biliary stones in a population-based case-control study conducted in Shanghai, China. Standard assays were used to detect HBV surface antigen (HBsAg) and antibodies against HBV core antigen (anti-HBc) and hepatitis C virus (anti-HCV) in sera from 417 patients with biliary tract cancers, 517 with biliary stones, and 762 healthy controls randomly selected from the population. Unconditional logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for each disease type. HBsAg seroprevalence was 7.3% among population controls and 14.2% among patients with extrahepatic bile duct cancer, resulting in a 2.4-fold risk of extrahepatic bile duct cancer (95% CI 1.2-4.5). No association was found for cancers of the gallbladder (prevalence 8.2%) or the ampulla of Vater (6.1%), or for stones in the gallbladder (10.1%) or bile duct (9.3%). Further adjustment for education, smoking, body mass index, diabetes and gallstones did not materially change the results. Prevalence of HCV infection in this population was low (2%), limiting our ability to detect an association with biliary diseases. In Shanghai, an HBV endemic area, chronic HBV infection was associated with a 2.4-fold risk of extrahepatic bile duct cancer. These results should be confirmed in other populations with varying risks of HBV and HCV infection. JF - International Journal of Cancer AU - Hsing, Ann W AU - Zhang, Mingdong AU - Rashid, Asif AU - McGlynn, Katherine A AU - Wang, Bing-Shen AU - Niwa, Shelley AU - Ortiz-Conde, Betty A AU - Goedert, James J AU - Fraumeni Jr, Joseph F AU - O'Brien, Thomas R AU - Gao, Yu-Tang AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, hsinga@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1849 EP - 1853 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 8 SN - 0020-7136, 0020-7136 KW - Virology & AIDS Abstracts; Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Hepatitis B surface antigen KW - hepatitis B KW - Smoking KW - diabetes mellitus KW - body mass KW - infection KW - Hepatitis B KW - Ampulla of Vater KW - population control KW - Core protein KW - Hepatitis B virus KW - Bile duct KW - Population studies KW - Biliary tract KW - Cancer KW - Hepatitis KW - Diabetes mellitus KW - Gallbladder KW - Education KW - Antibodies KW - Hepatitis C virus KW - surface antigens KW - Chronic infection KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Body mass index KW - B 26650:Viral Oncogenes KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20682346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Hepatitis+B+and+C+virus+infection+and+the+risk+of+biliary+tract+cancer%3A+A+population-based+study+in+China&rft.au=Hsing%2C+Ann+W%3BZhang%2C+Mingdong%3BRashid%2C+Asif%3BMcGlynn%2C+Katherine+A%3BWang%2C+Bing-Shen%3BNiwa%2C+Shelley%3BOrtiz-Conde%2C+Betty+A%3BGoedert%2C+James+J%3BFraumeni+Jr%2C+Joseph+F%3BO%27Brien%2C+Thomas+R%3BGao%2C+Yu-Tang&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2008-04-01&rft.volume=122&rft.issue=8&rft.spage=1849&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23251 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bile duct; Population studies; Hepatitis B surface antigen; Cancer; Biliary tract; Diabetes mellitus; Smoking; Gallbladder; Antibodies; surface antigens; Chronic infection; Hepatitis B; Body mass index; Ampulla of Vater; Core protein; Hepatitis; diabetes mellitus; Education; body mass; infection; hepatitis B; population control; Hepatitis C virus; Hepatitis B virus; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.23251 ER - TY - JOUR T1 - Nocardia wallacei sp. nov. and Nocardia blacklockiae sp. nov., Human Pathogens and Members of the "Nocardia transvalensis Complex" AN - 20668881; 8200467 AB - Nocardia isolates that share the property of in vitro amikacin resistance are grouped together by some authors in the Nocardia transvalensis complex. Our examination of 13 isolates that are amikacin resistant has revealed the existence of three distinct species. Sequence analysis of the 16S rRNA, 65-kDa heat shock protein, and secA1 genes, coupled with DNA-DNA hybridization, indicated that "N. asteroides drug pattern IV," "N. transvalensis new taxon 1," and N. transvalensis sensu stricto should each be considered a distinct species. The phenotypic and molecular characteristics of the proposed new species Nocardia wallacei (N. asteroides drug pattern IV) and N. blacklockiae (N. transvalensis new taxon 1) are presented and compared with those of N. transvalensis sensu stricto. The relative genetic diversity of isolates best placed with the species N. blacklockiae is also discussed. Case studies demonstrating the pathogenicity of N. wallacei and N. blacklockiae are presented. The type strain of N. wallacei is ATCC 49873 (DSM 45136), and that of N. blacklockiae is ATCC 700035 (DSM 45135). JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Brown, June M AU - Steigerwalt, Arnold G AU - Brown-Elliott, Barbara A AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland. Bacterial Zoonoses Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia. University of Texas Health Center, Department of Microbiology, Tyler, Texas Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1178 EP - 1184 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 4 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Nocardia transvalensis KW - Heat shock proteins KW - Amikacin KW - Pathogenicity KW - Genetic diversity KW - Pathogens KW - rRNA 16S KW - Drugs KW - New species KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20668881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Nocardia+wallacei+sp.+nov.+and+Nocardia+blacklockiae+sp.+nov.%2C+Human+Pathogens+and+Members+of+the+%22Nocardia+transvalensis+Complex%22&rft.au=Conville%2C+Patricia+S%3BBrown%2C+June+M%3BSteigerwalt%2C+Arnold+G%3BBrown-Elliott%2C+Barbara+A%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2008-04-01&rft.volume=46&rft.issue=4&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heat shock proteins; Pathogenicity; Amikacin; Genetic diversity; Pathogens; Drugs; rRNA 16S; New species; Nocardia transvalensis ER - TY - JOUR T1 - Molecular Characterization of Helicobacter pylori VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38MAPK in Activating Transcription Factor-2, cAMP Response Element Binding Protein, and NF- Kappa B Activation AN - 20664265; 8087550 AB - Helicobacter pylori VacA induces multiple effects on susceptible cells, including vacuolation, mitochondrial damage, inhibition of cell growth, and enhanced cyclooxygenase-2 expression. To assess the ability of H. pylori to modulate the production of inflammatory mediators, we examined the mechanisms by which VacA enhanced IL-8 production by promonocytic U937 cells, which demonstrated the greatest VacA-induced IL-8 release of the cells tested. Inhibitors of p38 MAPK (SB203580), ERK1/2 (PD98059), I Kappa B alpha ((E)-3-(4-methylphenylsulfonyl)-2-propenenitrile), Ca super(2+) entry (SKF96365), and intracellular Ca super(2+) channels (dantrolene) blocked VacA-induced IL-8 production. Furthermore, an intracellular Ca super(2+) chelator (BAPTA-AM), which inhibited VacA-activated p38 MAPK, caused a dose-dependent reduction in VacA-induced IL-8 secretion by U937 cells, implying a role for intracellular Ca super(2+) in mediating activation of MAPK and the canonical NF- Kappa B pathway. VacA stimulated translocation of NF- Kappa Bp65 to the nucleus, consistent with enhancement of IL-8 expression by activation of the NF- Kappa B pathway. In addition, small interfering RNA of activating transcription factor (ATF)-2 or CREB, which is a p38MAPK substrate and binds to the AP-1 site of the IL-8 promoter, inhibited VacA-induced IL-8 production. VacA activated an IL-8 promoter containing an NF-IL-6 site, but not a mutated AP-1 or NF- Kappa B site, suggesting direct involvement of the ATF-2/CREB binding region or NF- Kappa B-binding regions in VacA-induced IL-8 promoter activation. Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca super(2+) release, leading to activation of the transcription factors, ATF-2, CREB, and NF- Kappa B. JF - Journal of Immunology AU - Hisatsune, Junzo AU - Nakayama, Masaaki AU - Isomoto, Hajime AU - Kurazono, Hisao AU - Mukaida, Naofumi AU - Mukhopadhyay, Asish K AU - Azuma, Takeshi AU - Yamaoka, Yoshio AU - Sap, Jan AU - Yamasaki, Eiki AU - Yahiro, Kinnosuke AU - Moss, Joel AU - Hirayama, Toshiya AD - Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan. Department of Endoscopy, Nagasaki University School of Medicine, Nagasaki, Japan. Department of Applied Veterinary Medicine and Public Health, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan. Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan. Department of Gastroenterology, Kobe University School of Medicine, Kobe, Japan. Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030. Copenhagen Biocenter-Biotechnology and Innovation Centre, University of Copenhagen, Copenhagen, Denmark. Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 5017 EP - 5027 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 7 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Cyclooxygenase-2 KW - Helicobacter pylori KW - MAP kinase KW - Activating transcription factor 2 KW - Regulatory sequences KW - Activator protein 1 KW - Mitochondria KW - Chelating agents KW - Interleukin 8 KW - Calcium (intracellular) KW - NF- Kappa B protein KW - Inflammation KW - Nuclear transport KW - Promoters KW - Extracellular signal-regulated kinase KW - Calcium influx KW - siRNA KW - Transcription factors KW - Cyclic AMP response element-binding protein KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20664265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Molecular+Characterization+of+Helicobacter+pylori+VacA+Induction+of+IL-8+in+U937+Cells+Reveals+a+Prominent+Role+for+p38MAPK+in+Activating+Transcription+Factor-2%2C+cAMP+Response+Element+Binding+Protein%2C+and+NF-+Kappa+B+Activation&rft.au=Hisatsune%2C+Junzo%3BNakayama%2C+Masaaki%3BIsomoto%2C+Hajime%3BKurazono%2C+Hisao%3BMukaida%2C+Naofumi%3BMukhopadhyay%2C+Asish+K%3BAzuma%2C+Takeshi%3BYamaoka%2C+Yoshio%3BSap%2C+Jan%3BYamasaki%2C+Eiki%3BYahiro%2C+Kinnosuke%3BMoss%2C+Joel%3BHirayama%2C+Toshiya&rft.aulast=Hisatsune&rft.aufirst=Junzo&rft.date=2008-04-01&rft.volume=180&rft.issue=7&rft.spage=5017&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; MAP kinase; Regulatory sequences; Activating transcription factor 2; Activator protein 1; Mitochondria; Chelating agents; Interleukin 8; Inflammation; NF- Kappa B protein; Calcium (intracellular); Extracellular signal-regulated kinase; Promoters; Nuclear transport; Calcium influx; siRNA; Transcription factors; Cyclic AMP response element-binding protein; Helicobacter pylori ER - TY - JOUR T1 - Folate metabolism genes, vegetable intake and renal cancer risk in central Europe AN - 20658068; 8080065 AB - In a multicenter case-control study of renal cell carcinoma (RCC) conducted in central and eastern Europe, we reported a strong inverse association with high vegetable intake and RCC risk. The odds ratio (OR) for high compared to the lowest tertile of vegetable intake was OR = 0.67; (95% confidence interval (CI): 0.53-0.83; p-trend T (rs234706), Ex13 +41C > T (rs1801181), Ex18 -391 G > A (rs12613); MTHFR: A222V Ex5+79C > T (rs1801133), Ex8-62A > C (rs1801131); MTR: Ex26 20A > G (rs1805087), MTRR: Ex5+136 T > C (rs161870), and TYMS:IVS2-405 C > T (rs502396), Ex8+157 C > T (rs699517), Ex8+227 A > G (rs2790)) were analyzed among 1,097 RCC cases and 1,555 controls genotyped in this study. Having at least 1 variant T allele of MTHFR A222V was associated with higher RCC risk compared to those with 2 common (CC) alleles (OR = 1.44; 95% CI: 1.17-1.77; p = 0.001). After stratification by tertile of vegetable intake, the higher risk associated with the variant genotype was only observed in the low and medium tertiles (p-trend = 0.001), but not among those in the highest tertile (p-interaction = 0.22). The association remained robust after calculation of the false discovery rate (FDR = 0.05). Of the 3 TYMS SNPs examined, only the TYMS IVS2 -405 C (rs502396) variant was associated with a significantly lower risk compared to the common genotype (OR = 0.73; 95% CI: 0.57-0.93). Vegetable intake modified the association between all 3 TYMS SNPs and RCC risk (p-interaction < 0.04 for all). In summary, these findings suggest that common variation in MTHFR and TYMS genes may be associated with RCC risk, particularly when vegetable intake is low. JF - International Journal of Cancer AU - Moore, Lee E AU - Hung, Rayjean AU - Karami, Sara AU - Boffetta, Paolo AU - Berndt, Sonya AU - Hsu, Charles C AU - Zaridze, David AU - Janout, Vladimir AU - Kollarova, Helen AU - Bencko, Vladmir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, N AU - Mates, Dana AU - Mukeria, Anush AU - Holcatova, Ivana AU - Yeager, Meredith AU - Chanock, Stephen AU - Garcia-Closas, Montse AU - Rothman, Nat AU - Chow, Wong-Ho AU - Brennan, Paul AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, moorele@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1710 EP - 1715 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 8 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - Diets KW - Vegetables KW - Europe KW - Methylenetetrahydrofolate reductase KW - Stratification KW - Genotypes KW - Cancer KW - renal cell carcinoma KW - Single-nucleotide polymorphism KW - Risk factors KW - Kidney KW - Folic acid KW - Metabolism KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20658068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Folate+metabolism+genes%2C+vegetable+intake+and+renal+cancer+risk+in+central+Europe&rft.au=Moore%2C+Lee+E%3BHung%2C+Rayjean%3BKarami%2C+Sara%3BBoffetta%2C+Paolo%3BBerndt%2C+Sonya%3BHsu%2C+Charles+C%3BZaridze%2C+David%3BJanout%2C+Vladimir%3BKollarova%2C+Helen%3BBencko%2C+Vladmir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+N%3BMates%2C+Dana%3BMukeria%2C+Anush%3BHolcatova%2C+Ivana%3BYeager%2C+Meredith%3BChanock%2C+Stephen%3BGarcia-Closas%2C+Montse%3BRothman%2C+Nat%3BChow%2C+Wong-Ho%3BBrennan%2C+Paul&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2008-04-01&rft.volume=122&rft.issue=8&rft.spage=1710&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23318 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Vegetables; renal cell carcinoma; Single-nucleotide polymorphism; Risk factors; Kidney; Methylenetetrahydrofolate reductase; Genotypes; Folic acid; Metabolism; Diets; Stratification; Cancer; Europe DO - http://dx.doi.org/10.1002/ijc.23318 ER - TY - JOUR T1 - Adoptive cell transfer: a clinical path to effective cancer immunotherapy AN - 20623906; 8112395 AB - Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged as the most effective treatment for patients with metastatic melanoma and can mediate objective cancer regression in approximately 50% of patients. The use of donor lymphocytes for ACT is an effective treatment for immunosuppressed patients who develop post-transplant lymphomas. The ability to genetically engineer human lymphocytes and use them to mediate cancer regression in patients, which has recently been demonstrated, has opened possibilities for the extension of ACT immunotherapy to patients with a wide variety of cancer types and is a promising new approach to cancer treatment. JF - Nature Reviews: Cancer AU - Rosenberg, Steven A AU - Restifo, Nicholas P AU - Yang, James C AU - Morgan, Richard A AU - Dudley, Mark E AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA., sar@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 299 EP - 308 PB - Nature Publishing Group, Brunel Road Houndmills Basingstoke Hampshire RG21 6XS UK, [URL:http://www.naturesj.com/sj/index.html] VL - 8 IS - 4 SN - 1474-175X, 1474-175X KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts; Immunology Abstracts KW - Metastases KW - Immunotherapy KW - Reviews KW - Lymphocytes KW - Lymphoma KW - Cancer KW - Melanoma KW - W 30925:Genetic Engineering KW - B 26690:General, Reviews, Book Notices KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20623906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Cancer&rft.atitle=Adoptive+cell+transfer%3A+a+clinical+path+to+effective+cancer+immunotherapy&rft.au=Rosenberg%2C+Steven+A%3BRestifo%2C+Nicholas+P%3BYang%2C+James+C%3BMorgan%2C+Richard+A%3BDudley%2C+Mark+E&rft.aulast=Rosenberg&rft.aufirst=Steven&rft.date=2008-04-01&rft.volume=8&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc2355 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Metastases; Reviews; Immunotherapy; Lymphocytes; Lymphoma; Cancer; Melanoma DO - http://dx.doi.org/10.1038/nrc2355 ER - TY - JOUR T1 - Risks of cancer among a cohort of 23,935 men and women with osteoporosis AN - 20621571; 8080088 AB - Low hormone levels among persons with osteoporosis may decrease risk of some cancers. Other osteoporosis risk factors, such as smoking and alcohol consumption, however, may increase risk. As these deleterious factors are more often associated with osteoporosis diagnosed prior to age 70 years, cancer risk may be higher in these younger persons than in the general population. To examine this hypothesis, a cohort study of 23,935 persons with osteoporosis was conducted in Denmark. Patients hospitalized with osteoporosis between 1978 and 1993 were identified in the Danish Inpatient Register. Linkage to the Danish Cancer Registry identified all cancer outcomes through 2003. Standardized incidence ratios (SIR) and 95% confidence intervals (95%CI) were calculated to compare cancer incidence in the cohort with that in the general population. Persons diagnosed prior to age 70 years were at increased cancer risk (women: SIR = 1.11, 95%CI = 1.04-1.19; men: SIR = 1.31, 95%CI = 1.13-1.50) due, in part, to increased risks of cancers of the buccal cavity, esophagus, liver, pancreas and lung. Persons diagnosed at ages 70 and older were at decreased risk (women: SIR = 0.91, 95%CI = 0.87-0.96; men: SIR = 0.89, 0.77-1.01) due, in part, to decreased risks of breast, endometrial, colon, rectal and brain cancers in women and prostate cancer in men. These results suggest that risk factors associated with earlier onset osteoporosis may be associated with increased risk of cancer. Conversely, factors associated with later onset osteoporosis may be related to a decreased risk of cancer. JF - International Journal of Cancer AU - McGlynn, Katherine A AU - Gridley, Gloria AU - Mellemkjaer, Lene AU - Brinton, Louise A AU - Anderson, Kenneth C AU - Caporaso, Neil E AU - Landgren, Ola AU - Olsen, Jorgen H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, mcglynnk@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1879 EP - 1884 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 8 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Age KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - Hormones KW - Smoking KW - osteoporosis KW - Denmark KW - prostate cancer KW - Alcohol KW - Brain KW - males KW - Cancer KW - Lung KW - Liver KW - Females KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20621571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risks+of+cancer+among+a+cohort+of+23%2C935+men+and+women+with+osteoporosis&rft.au=McGlynn%2C+Katherine+A%3BGridley%2C+Gloria%3BMellemkjaer%2C+Lene%3BBrinton%2C+Louise+A%3BAnderson%2C+Kenneth+C%3BCaporaso%2C+Neil+E%3BLandgren%2C+Ola%3BOlsen%2C+Jorgen+H&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2008-04-01&rft.volume=122&rft.issue=8&rft.spage=1879&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23290 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir; Denmark; Cancer; osteoporosis; Age; Alcohol; Brain; Hormones; Liver; males; Females; prostate cancer; Lung; Smoking DO - http://dx.doi.org/10.1002/ijc.23290 ER - TY - JOUR T1 - Mercury-induced cognitive impairment in metallothionein-1/2 null mice AN - 20574951; 8093212 AB - Metallothioneins are central for the metabolism and detoxification of transition metals. Exposure to mercury during early neurodevelopment is associated with neurocognitive impairment. Given the importance of metallothioneins in mercury detoxification, metallothioneins may be a protective factor against mercury-induced neurocognitive impairment. Deletion of the murine metallothionein-1 and metallothionein-2 genes causes choice accuracy impairments in the 8-arm radial maze. We hypothesize that deletions of metallothioneins genes will make metallothionein-null mice more vulnerable to mercury-induced cognitive impairment. We tested this hypothesis by exposing MT1/MT2-null and wild-type mice to developmental mercury (HgCl sub(2)) and evaluated the resultant effects on cognitive performance on the 8-arm radial maze. During the early phase of learning metallothionein-null mice were more susceptible to mercury-induced impairment compared to wildtype mice. Neurochemical analysis of the frontal cortex revealed that serotonin levels were higher in metallothionein-null mice compared to wild-type mice. This effect was independent of mercury exposure. However, dopamine levels in mercury-exposed metallothionein-null mice were lower compared to mercury-exposed wild-type mice. This work shows that deleting metallothioneins increase the vulnerability to developmental mercury-induced neurocognitive impairment. Metallothionein effects on monoamine transmitters may be related to this cognitive effect. JF - Neurotoxicology and Teratology AU - Eddins, D AU - Petro, A AU - Pollard, N AU - Freedman, J H AU - Levin, ED AD - Duke University, United States, freedma1@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 88 EP - 95 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 30 IS - 2 SN - 0892-0362, 0892-0362 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Detoxification KW - monoamines KW - Learning KW - Metallothionein KW - Cortex (frontal) KW - Transition metals KW - Cognition KW - Serotonin KW - Dopamine KW - Cognitive ability KW - Mercury KW - Metabolism KW - N3 11003:Developmental neuroscience KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20574951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Mercury-induced+cognitive+impairment+in+metallothionein-1%2F2+null+mice&rft.au=Eddins%2C+D%3BPetro%2C+A%3BPollard%2C+N%3BFreedman%2C+J+H%3BLevin%2C+ED&rft.aulast=Eddins&rft.aufirst=D&rft.date=2008-04-01&rft.volume=30&rft.issue=2&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2007.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Detoxification; Learning; monoamines; Dopamine; Metallothionein; Cognitive ability; Cortex (frontal); Mercury; Transition metals; Metabolism; Serotonin; Cognition DO - http://dx.doi.org/10.1016/j.ntt.2007.12.005 ER - TY - JOUR T1 - Biologic treatments for systemic rheumatic diseases AN - 20468053; 9151444 AB - Many rheumatologic disorders, most notably Sjoegren's syndrome, are associated with dental complications and in some cases oral diseases may trigger or drive connective tissue disease. During the past three decades the treatment in rheumatology was revolutionized by the introduction of disease-modifying anti-rheumatic drugs. Advances in our understanding of the pathogenesis of rheumatic diseases have led to the discovery of critical mechanisms of inflammation and autoimmunity and the invention of new target-specific biologic agents. In this review, we will summarize the current state of biologic therapies in rheumatology and discuss the implications of these on oral health and disease. JF - Oral Diseases AU - Shirota, Y AU - Illei, G G AU - Nikolov, N P AD - Sjoegren's Syndrome Clinic, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA, nikolovn@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 206 EP - 216 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 14 IS - 3 SN - 1354-523X, 1354-523X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - autoimmunity KW - biologic therapies KW - monoclonal antibodies KW - rheumatic diseases KW - Sjoegren's syndrome KW - Sjogren's syndrome KW - Oral diseases KW - Autoimmune diseases KW - Connective tissue diseases KW - Drugs KW - Rheumatic diseases KW - Inflammation KW - F 06930:Autoimmunity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20468053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+Diseases&rft.atitle=Biologic+treatments+for+systemic+rheumatic+diseases&rft.au=Shirota%2C+Y%3BIllei%2C+G+G%3BNikolov%2C+N+P&rft.aulast=Shirota&rft.aufirst=Y&rft.date=2008-04-01&rft.volume=14&rft.issue=3&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Oral+Diseases&rft.issn=1354523X&rft_id=info:doi/10.1111%2Fj.1601-0825.2008.01440.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sjogren's syndrome; Oral diseases; Autoimmune diseases; Connective tissue diseases; Drugs; Inflammation; Rheumatic diseases DO - http://dx.doi.org/10.1111/j.1601-0825.2008.01440.x ER - TY - JOUR T1 - Estimation of the bottleneck size in Florida panthers AN - 20435076; 9121392 AB - AbstractWe have estimated the extent of genetic variation in museum (1890s) and contemporary (1980s) samples of Florida panthers Puma concolor coryi for both nuclear loci and mtDNA. The microsatellite heterozygosity in the contemporary sample was only 0.325 that in the museum samples although our sample size and number of loci are limited. Support for this estimate is provided by a sample of 84 microsatellite loci in contemporary Florida panthers and Idaho pumas Puma concolor hippolestes in which the contemporary Florida panther sample had only 0.442 the heterozygosity of Idaho pumas. The estimated diversities in mtDNA in the museum and contemporary samples were 0.600 and 0.000, respectively. Using a population genetics approach, we have estimated that to reduce either the microsatellite heterozygosity or the mtDNA diversity this much (in a period of c. 80years during the 20th century when the numbers were thought to be low) that a very small bottleneck size of c. 2 for several generations and a small effective population size in other generations is necessary. Using demographic data from Yellowstone pumas, we estimated the ratio of effective to census population size to be 0.315. Using this ratio, the census population size in the Florida panthers necessary to explain the loss of microsatellite variation was c. 41 for the non-bottleneck generations and 6.2 for the two bottleneck generations. These low bottleneck population sizes and the concomitant reduced effectiveness of selection are probably responsible for the high frequency of several detrimental traits in Florida panthers, namely undescended testicles and poor sperm quality. The recent intensive monitoring both before and after the introduction of Texas pumas in 1995 will make the recovery and genetic restoration of Florida panthers a classic study of an endangered species. Our estimates of the bottleneck size responsible for the loss of genetic variation in the Florida panther completes an unknown aspect of this account. JF - Animal Conservation AU - Culver, M AU - Hedrick, P W AU - Murphy, K AU - O'Brien, S AU - Hornocker, M G AD - 1 Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 104 EP - 110 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 11 IS - 2 SN - 1367-9430, 1367-9430 KW - Ecology Abstracts; Sustainability Science Abstracts KW - computer simulation KW - effective population size KW - endangered species KW - microsatellite loci KW - mtDNA KW - census KW - demography KW - population number KW - USA, Florida KW - Microsatellites KW - Museums KW - Genetic diversity KW - genetic diversity KW - Sperm KW - Florida panthers KW - Heterozygosity KW - pumas KW - population genetics KW - Population genetics KW - USA, Idaho KW - Mitochondrial DNA KW - Endangered species KW - Conservation KW - Census KW - USA, Texas KW - M3 1010:Issues in Sustainable Development KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20435076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Animal+Conservation&rft.atitle=Estimation+of+the+bottleneck+size+in+Florida+panthers&rft.au=Culver%2C+M%3BHedrick%2C+P+W%3BMurphy%2C+K%3BO%27Brien%2C+S%3BHornocker%2C+M+G&rft.aulast=Culver&rft.aufirst=M&rft.date=2008-04-01&rft.volume=11&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Animal+Conservation&rft.issn=13679430&rft_id=info:doi/10.1111%2Fj.1469-1795.2007.00154.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Population genetics; Mitochondrial DNA; Museums; Microsatellites; Genetic diversity; Census; Sperm; Heterozygosity; demography; census; population genetics; population number; Conservation; Endangered species; genetic diversity; Florida panthers; pumas; USA, Idaho; USA, Florida; USA, Texas DO - http://dx.doi.org/10.1111/j.1469-1795.2007.00154.x ER - TY - JOUR T1 - Improving Exercise Tolerance in Chronic Heart Failure: A Tale of Inspiration? AN - 20244750; 8863849 JF - Journal of the American College of Cardiology AU - Fleg, Jerome L AD - National Heart, Lung, and Blood Institute, Bethesda, Maryland., flegj@nhlbi.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1672 EP - 1674 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.com] VL - 51 IS - 17 SN - 0735-1097, 0735-1097 KW - Physical Education Index KW - Heart KW - Exercise (tolerance) KW - Higher education KW - Failure KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20244750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Improving+Exercise+Tolerance+in+Chronic+Heart+Failure%3A+A+Tale+of+Inspiration%3F&rft.au=Fleg%2C+Jerome+L&rft.aulast=Fleg&rft.aufirst=Jerome&rft.date=2008-04-01&rft.volume=51&rft.issue=17&rft.spage=1672&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2008.01.027 LA - English DB - Physical Education Index N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Higher education; Exercise (tolerance); Failure DO - http://dx.doi.org/10.1016/j.jacc.2008.01.027 ER - TY - JOUR T1 - MtBE and cancer in animals: Statistical issues with poly-3 survival adjustments for lifetime studies AN - 20043574; 8255966 JF - Regulatory Toxicology and Pharmacology AU - Kissling, GE AU - Portier, C J AU - Huff, J AD - Grace E. Kissling. NIEHS, kissling@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 428 EP - 429 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 50 IS - 3 SN - 0273-2300, 0273-2300 KW - Pollution Abstracts; Aqualine Abstracts; Water Resources Abstracts; Toxicology Abstracts KW - Water Pollution KW - Animals KW - Statistics KW - MTBE KW - Survival KW - Cancer KW - survival KW - SW 3030:Effects of pollution KW - AQ 00008:Effects of Pollution KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20043574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=MtBE+and+cancer+in+animals%3A+Statistical+issues+with+poly-3+survival+adjustments+for+lifetime+studies&rft.au=Kissling%2C+GE%3BPortier%2C+C+J%3BHuff%2C+J&rft.aulast=Kissling&rft.aufirst=GE&rft.date=2008-04-01&rft.volume=50&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2007.07.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Statistics; MTBE; Survival; Cancer; Animals; survival; Water Pollution DO - http://dx.doi.org/10.1016/j.yrtph.2007.07.008 ER - TY - JOUR T1 - The impact of tobacco smoking and alcohol drinking on survival of patients with non-Hodgkin lymphoma AN - 20004666; 8080050 AB - Tobacco smoking and alcohol consumption have not been clearly related to the risk of non-Hodgkin lymphoma (NHL), and the impact of these two factors on survival of NHL patients has received little attention. Cases were 268 subjects with incident histologically-confirmed NHL, admitted as inpatients to the Division of Medical Oncology, between 1983 and 2002. These individuals were enrolled as cases in case-control studies conducted at the same institution over the same period. For all patients clinical (histological subtype, major prognostic factors and treatment) and epidemiological data (smoking and drinking habits) were available. Survival analysis was performed using Kaplan-Meier methods. Hazard ratio (HR) was estimated by Cox proportional hazard model. Compared to never smokers, patients who smoked 20 cigarettes/day had higher risks of death (HR = 1.70, 95% confidence interval (CI): 1.06-2.73) and lower survivals at 5 years (60 and 46%, respectively). Likewise, patients who drunk 4 drinks/day showed 1.69-fold higher probability of death (95% CI: 1.04-2.76) in comparison to drinkers of <2 drinks/day (5-year survival: 47 and 67%, respectively). When combining exposure to alcohol and tobacco, no excess of death emerged in light drinkers (<4 drinks/day), irrespective of their smoking habits, but higher risks of death emerged among heavy drinkers. In the present study, heavy tobacco smoking, and particularly, heavy alcohol drinking were associated with poor survival in NHL patients. Our findings strongly encourage physicians to advice NHL patients to stop smoking and diminish alcohol consumption to obtain improvements in the course of NHL. JF - International Journal of Cancer AU - Talamini, Renato AU - Polesel, Jerry AU - Spina, Michele AU - Chimienti, Emanuela AU - Serraino, Diego AU - Zucchetto, Antonella AU - Zanet, Ernesto AU - Franceschi, Silvia AU - Tirelli, Umberto AD - Unit of Epidemiology and Biostatistics, National Cancer Institute, Aviano, Italy, talaminir@cro.it Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1624 EP - 1629 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 7 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts KW - Cigarettes KW - Survival KW - Oncology KW - Models KW - Non-Hodgkin's lymphoma KW - Risk factors KW - Tobacco KW - Lymphoma KW - Ethanol KW - Tobacco smoking KW - Mortality KW - Alcohol KW - Data processing KW - Beverages KW - Cancer KW - Drinking behavior KW - survival KW - lymphoma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20004666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=The+impact+of+tobacco+smoking+and+alcohol+drinking+on+survival+of+patients+with+non-Hodgkin+lymphoma&rft.au=Talamini%2C+Renato%3BPolesel%2C+Jerry%3BSpina%2C+Michele%3BChimienti%2C+Emanuela%3BSerraino%2C+Diego%3BZucchetto%2C+Antonella%3BZanet%2C+Ernesto%3BFranceschi%2C+Silvia%3BTirelli%2C+Umberto&rft.aulast=Talamini&rft.aufirst=Renato&rft.date=2008-04-01&rft.volume=122&rft.issue=7&rft.spage=1624&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23205 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - survival; Non-Hodgkin's lymphoma; Alcohol; Mortality; Tobacco; lymphoma; Cancer; Cigarettes; Survival; Ethanol; Beverages; Tobacco smoking; Drinking behavior; Risk factors; Lymphoma; Data processing; Models; Oncology DO - http://dx.doi.org/10.1002/ijc.23205 ER - TY - JOUR T1 - Highly pathogenic RNA viral infections: Challenges for antiviral research AN - 19895991; 8254817 AB - A number of RNA viruses can cause severe disease when transmitted to humans from an animal reservoir. One of them, the recently emerged H5N1 subtype of influenza A virus, has caused several hundred cases of severe disease when transferred directly from domestic poultry. This or another avian subtype could potentially evolve to a form more transmissible by the respiratory route or reassort with a circulating strain to initiate a pandemic. Other zoonotic RNA viruses cause sporadic single cases or outbreaks of hemorrhagic fever or encephalitis that spread inefficiently from person-to-person, and thus remain confined to the geographic range of the maintenance host. RNA viral infections of farm animals, such as foot and mouth disease and classical swine fever, also pose a major threat to human well-being through economic loss and impaired nutrition. Only a few licensed antiviral drugs are available to prevent or treat these conditions. Medications that inhibit the replication of influenza virus might be used in an epidemic both to treat severe disease and to block the spread of infection. The guanosine analog ribavirin has been used to treat a few types of hemorrhagic fever, but there is no specific therapy for the others, or for any type of RNA viral encephalitis. The quest for new antivirals is being supported by government programs and new collaborative research networks. Major efforts will be required to identify active compounds, test their efficacy in laboratory animals, obtain approval for human use and develop rapid diagnostic methods that can identify patients early enough in the disease course for treatment to be of benefit. JF - Antiviral Research AU - Bray, M AD - Division of Clinical Research/National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 5128, 6700A Rockledge Drive, Bethesda, MD 20892, USA, mbray@niaid.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1 EP - 8 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 78 IS - 1 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Poultry KW - Farms KW - Epidemics KW - Replication KW - Ribavirin KW - Laboratory animals KW - RNA viruses KW - Infection KW - Nutrition KW - Encephalitis KW - Foot-and-mouth disease KW - Classical swine fever virus KW - Disease transmission KW - pandemics KW - Hog cholera KW - Antiviral agents KW - Influenza A virus KW - Economics KW - Hemorrhagic fever KW - Guanosine KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Highly+pathogenic+RNA+viral+infections%3A+Challenges+for+antiviral+research&rft.au=Bray%2C+M&rft.aulast=Bray&rft.aufirst=M&rft.date=2008-04-01&rft.volume=78&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2007.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Poultry; Epidemics; Farms; Replication; Ribavirin; Laboratory animals; RNA viruses; Infection; Nutrition; Foot-and-mouth disease; Encephalitis; Disease transmission; pandemics; Antiviral agents; Hog cholera; Economics; Hemorrhagic fever; Guanosine; Influenza A virus; Classical swine fever virus DO - http://dx.doi.org/10.1016/j.antiviral.2007.12.007 ER - TY - JOUR T1 - Current and future antiviral therapy of severe seasonal and avian influenza AN - 19890292; 8254217 AB - The currently circulating H3N2 and H1N1 subtypes of influenza A virus cause a transient, febrile upper respiratory illness in most adults and children (''seasonal influenza''), but infants, the elderly, immunodeficient and chronically ill persons may develop life-threatening primary viral pneumonia or complications such as bacterial pneumonia. By contrast, avian influenza viruses such as the H5N1 virus that recently emerged in Southeast Asia can cause severe disease when transferred from domestic poultry to previously healthy people (''avian influenza''). Most H5N1 patients present with fever, cough and shortness of breath that progress rapidly to adult respiratory distress syndrome. In seasonal influenza, viral replication remains confined to the respiratory tract, but limited studies indicate that H5N1 infections are characterized by systemic viral dissemination, high cytokine levels and multiorgan failure. Gastrointestinal infection and encephalitis also occur. The licensed anti-influenza drugs (the M2 ion channel blockers, amantadine and rimantadine, and the neuraminidase inhibitors, oseltamivir and zanamivir) are beneficial for uncomplicated seasonal influenza, but appropriate dosing regimens for severe seasonal or H5N1 viral infections have not been defined. Treatment options may be limited by the rapid emergence of drug-resistant viruses. Ribavirin has also been used to a limited extent to treat influenza. This article reviews licensed drugs and treatments under development, including high-dose oseltamivir; parenterally administered neuraminidase inhibitors, peramivir and zanamivir; dimeric forms of zanamivir; the RNA polymerase inhibitor T-705; a ribavirin prodrug, viramidine; polyvalent and monoclonal antibodies; and combination therapies. JF - Antiviral Research AU - Beigel, J AU - Bray, M AD - National Institutes of Health, Bethesda, MD 20892, USA, jbeigel@niaid.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 91 EP - 102 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 78 IS - 1 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Poultry KW - Drug resistance KW - Ribavirin KW - Immunodeficiency KW - Infection KW - Zanamivir KW - Fever KW - DNA-directed RNA polymerase KW - Antiviral agents KW - prodrugs KW - Influenza A virus KW - Ion channels KW - Geriatrics KW - Cytokines KW - Exo- alpha -sialidase KW - Respiratory tract KW - Replication KW - Monoclonal antibodies KW - Cough KW - Drug development KW - Children KW - Encephalitis KW - Oseltamivir KW - Fowl plague KW - Reviews KW - Amantadine KW - Pneumonia KW - Adult respiratory distress syndrome KW - Infants KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19890292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Current+and+future+antiviral+therapy+of+severe+seasonal+and+avian+influenza&rft.au=Beigel%2C+J%3BBray%2C+M&rft.aulast=Beigel&rft.aufirst=J&rft.date=2008-04-01&rft.volume=78&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2008.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Poultry; Drug resistance; Ribavirin; Immunodeficiency; Infection; Zanamivir; Fever; DNA-directed RNA polymerase; prodrugs; Antiviral agents; Ion channels; Geriatrics; Cytokines; Exo- alpha -sialidase; Respiratory tract; Monoclonal antibodies; Replication; Cough; Drug development; Children; Encephalitis; Oseltamivir; Fowl plague; Reviews; Amantadine; Pneumonia; Infants; Adult respiratory distress syndrome; Influenza A virus DO - http://dx.doi.org/10.1016/j.antiviral.2008.01.003 ER - TY - JOUR T1 - Multilaboratory Testing of Antifungal Combinations against a Quality Control Isolate of Candida krusei AN - 19890089; 8083473 AB - Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lower than the MICs of any two drugs tested singly, and combinations of AMB, PSC, CSP, and VRC were indifferent (no antagonism) by summations of fractional inhibitory concentration. JF - Antimicrobial Agents & Chemotherapy AU - Chaturvedi, Vishnu AU - Ramani, Rama AU - Ghannoum, Mahmoud A AU - Killian, Scott B AU - Holliday, Nicole AU - Knapp, Cindy AU - Ostrosky-Zeichner, Luis AU - Messer, Shawn A AU - Pfaller, Michael A AU - Iqbal, Naureen J AU - Arthington-Skaggs, Beth A AU - Vazquez, Jose A AU - Sein, Tin AU - Rex, John H AU - Walsh, Thomas J AD - Mycology Laboratory, Wadsworth Center, New York State Department of Health, Albany, New York. Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio. TREK Diagnostic Systems, Cleveland, Ohio. University of Texas, Houston, Texas. University of Iowa, Iowa City, Iowa. Centers for Disease Control and Prevention, Atlanta, Georgia. Wayne State University, Detroit, Michigan. National Cancer Institute, Bethesda, Maryland. AstraZeneca Pharmaceuticals, Cheshire, United Kingdom Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1500 EP - 1502 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Amphotericin B KW - Quality control KW - Caspofungin KW - Voriconazole KW - Candida krusei KW - Antagonism KW - Posaconazole KW - Minimum inhibitory concentration KW - Drugs KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19890089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Multilaboratory+Testing+of+Antifungal+Combinations+against+a+Quality+Control+Isolate+of+Candida+krusei&rft.au=Chaturvedi%2C+Vishnu%3BRamani%2C+Rama%3BGhannoum%2C+Mahmoud+A%3BKillian%2C+Scott+B%3BHolliday%2C+Nicole%3BKnapp%2C+Cindy%3BOstrosky-Zeichner%2C+Luis%3BMesser%2C+Shawn+A%3BPfaller%2C+Michael+A%3BIqbal%2C+Naureen+J%3BArthington-Skaggs%2C+Beth+A%3BVazquez%2C+Jose+A%3BSein%2C+Tin%3BRex%2C+John+H%3BWalsh%2C+Thomas+J&rft.aulast=Chaturvedi&rft.aufirst=Vishnu&rft.date=2008-04-01&rft.volume=52&rft.issue=4&rft.spage=1500&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Quality control; Voriconazole; Caspofungin; Antagonism; Posaconazole; Drugs; Minimum inhibitory concentration; Candida krusei ER - TY - JOUR T1 - Amphotericin B formulations variably enhance antifungal activity of human neutrophils and monocytes against Fusarium solani: comparison with Aspergillus fumigatus AN - 19886355; 8086235 AB - OBJECTIVES: Lipid formulations of amphotericin B (AMBF) are widely used in the treatment of life-threatening infections caused by Aspergillus fumigatus and Fusarium solani. We aimed to compare the immunomodulatory effects of four AMBF, deoxycholate (DAMB), liposomal (LAMB), lipid complex (ABLC) and colloidal dispersion (ABCD), on the oxidative antifungal activities of human neutrophils (PMNs) and monocytes (MNCs) against hyphae of A. fumigatus and F. solani. METHODS: Human PMNs and MNCs were pre-incubated with 1 or 5 mg/L DAMB and 5 or 25 mg/L for each of LAMB, ABLC and ABCD. Hyphal damage was then assessed by XTT assay, and O sub(2) super(-) production was assessed by cytochrome c assay. RESULTS: All agents resulted in increased hyphal damage induced by phagocytes against both A. fumigatus and F. solani (P < 0.05). The high concentrations of AMBF elicited higher phagocyte-induced hyphal damage of both fungi than the low concentrations. There was, however, no consistent superiority of any of the AMBF or substantial effector cell:target ratio-dependent differences in the degree of hyphal damage enhancement. By comparison, O sub(2) super(-) produced by PMNs or MNCs upon hyphal challenge was not generally affected by any of the AMBF. F. solani hyphae were significantly more resistant to H sub(2)O sub(2) than A. fumigatus. CONCLUSIONS: These findings suggest that AMBF have enhancing effects of variable degree on phagocyte-induced hyphal damage of A. fumigatus and F. solani. Other fungicidal mechanisms, perhaps non-oxidative, are more likely to mediate these immunomodulatory effects of AMBF on host defence against the two medically important filamentous fungi. JF - Journal of Antimicrobial Chemotherapy AU - Dotis, John AU - Simitsopoulou, Maria AU - Dalakiouridou, Maria AU - Konstantinou, Thomai AU - Panteliadis, Christos AU - Walsh, Thomas J AU - Roilides, Emmanuel AD - Laboratory of Infectious Diseases, 3rd Department of Paediatrics, School of Medicine, Aristotle University, Hippokration Hospital, Thessaloniki 54642, Greece. Laboratory of Medical Biotechnology, Department of Medical Laboratories, Technological Educational Institute of Thessaloniki, Thessaloniki 57400, Greece. Immunocompromised Host Section, National Cancer Institute, Bethesda, MD 20892, USA Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 810 EP - 817 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 61 IS - 4 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Amphotericin B KW - Lipids KW - Fungi KW - Hyphae KW - Leukocytes (neutrophilic) KW - Infection KW - Cytochrome c KW - Hydrogen peroxide KW - Phagocytes KW - Aspergillus fumigatus KW - Antifungal activity KW - Monocytes KW - Fusarium solani KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19886355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Amphotericin+B+formulations+variably+enhance+antifungal+activity+of+human+neutrophils+and+monocytes+against+Fusarium+solani%3A+comparison+with+Aspergillus+fumigatus&rft.au=Dotis%2C+John%3BSimitsopoulou%2C+Maria%3BDalakiouridou%2C+Maria%3BKonstantinou%2C+Thomai%3BPanteliadis%2C+Christos%3BWalsh%2C+Thomas+J%3BRoilides%2C+Emmanuel&rft.aulast=Dotis&rft.aufirst=John&rft.date=2008-04-01&rft.volume=61&rft.issue=4&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Cytochrome c; Phagocytes; Hydrogen peroxide; Fungi; Lipids; Hyphae; Antifungal activity; Leukocytes (neutrophilic); Monocytes; Infection; Aspergillus fumigatus; Fusarium solani ER - TY - JOUR T1 - The Presence of Capsule in Cryptococcus neoformans Influences the Gene Expression Profile in Dendritic Cells during Interaction with the Fungus AN - 19713264; 8086159 AB - The aim of this investigation was to study the effect of polysaccharide capsule on the gene expression in dendritic cells (DC) during their interaction with Cryptococcus neoformans. To this end, we used an encapsulated virulent strain of C. neoformans and a cap59 gene-disrupted acapsular avirulent strain derived from the same genetic background. DC were exposed to encapsulated and acapsular C. neoformans strains for 4 h and 18 h, and their transcriptional profiles were analyzed using the Affymetrix mouse gene chip U74Av2. A large number of DC genes were up-regulated after treatment with the acapsular strain. In particular, we observed the up-regulation of the genes involved in DC maturation, such as cell surface receptors, cytokines, and chemokines (interleukin-12 [IL-12], IL-2, IL-1 alpha , IL-1 beta , IL-6, IL-10, tumor necrosis factor alpha, CCR7, CCL17, CCL22, CCL3, CCL4, CCL7, and CXCL10), membrane proteins, and the genes involved in antigen processing and presentation as well as cell cycle or apoptosis. The chemokine gene expression data were confirmed by real-time reverse transcription-PCR, while the expression of cytokine genes was correlated with their secretion. A completely different pattern of gene expression was observed for DC treated with an encapsulated strain of C. neoformans. In particular, no significant induction was observed in the expression of the genes mentioned above. Moreover, a number of genes, such as those coding for chemokines, were down-regulated. These results suggest that the polysaccharide capsule shrouding the cell wall of C. neoformans plays a fundamental role in inducing DC response, highlighting the molecular basis of the true nature of immune silencing exerted by capsular material. JF - Infection and Immunity AU - Lupo, P AU - Chang, Y C AU - Kelsall, B L AU - Farber, J M AU - Pietrella, D AU - Vecchiarelli, A AU - Leon, F AU - Kwon-Chung, K J AD - Laboratory of Clinical Investigation. Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892. Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06123 Perugia, Italy Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 1581 EP - 1589 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 4 SN - 0019-9567, 0019-9567 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Cell surface KW - Chemokines KW - CCL4 protein KW - Apoptosis KW - Interleukin 2 KW - Interleukin 1 KW - Cell cycle KW - Membrane proteins KW - Polysaccharides KW - Antigen presentation KW - Interleukin 10 KW - Gene expression KW - Dendritic cells KW - Interleukin 12 KW - CC chemokine receptors KW - Cryptococcus neoformans KW - Antigen processing KW - CCL22 protein KW - CCL17 protein KW - Data processing KW - CCL3 protein KW - Transcription KW - CXCL10 protein KW - Tumor necrosis factor- alpha KW - CCR7 protein KW - Cell walls KW - W 30940:Products KW - F 06910:Microorganisms & Parasites KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19713264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Presence+of+Capsule+in+Cryptococcus+neoformans+Influences+the+Gene+Expression+Profile+in+Dendritic+Cells+during+Interaction+with+the+Fungus&rft.au=Lupo%2C+P%3BChang%2C+Y+C%3BKelsall%2C+B+L%3BFarber%2C+J+M%3BPietrella%2C+D%3BVecchiarelli%2C+A%3BLeon%2C+F%3BKwon-Chung%2C+K+J&rft.aulast=Lupo&rft.aufirst=P&rft.date=2008-04-01&rft.volume=76&rft.issue=4&rft.spage=1581&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Cell surface; Chemokines; Apoptosis; CCL4 protein; Interleukin 2; Cell cycle; Interleukin 1; Membrane proteins; Antigen presentation; Polysaccharides; Interleukin 10; Gene expression; Interleukin 12; Dendritic cells; CC chemokine receptors; Antigen processing; CCL22 protein; CCL17 protein; Data processing; CCL3 protein; Transcription; CXCL10 protein; Tumor necrosis factor- alpha; CCR7 protein; Cell walls; Cryptococcus neoformans ER - TY - JOUR T1 - Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects AN - 19711228; 8085558 AB - The congenital malformation Split Hand-Foot Malformation (SHFM, or ectrodactyly) is characterized by a medial cleft of hands and feet, and missing central fingers. Five genetically distinct forms are known in humans; the most common (type-I) is linked to deletions of DSS1 and the distalless-related homeogenes DLX5 and DLX6. As Dlx5; Dlx6 double-knockout mice show a SHFM-like phenotype, the human orthologs are believed to be the disease genes. SHFM-IV and Ectrodactyly-Ectodermal dysplasia-Cleft lip (EEC) are caused by mutations in p63, an ectoderm-specific p53-related transcription factor. The similarity in the limb phenotype of different forms of SHFM may underlie the existence of a regulatory cascade involving the disease genes. Here, we show that p63 and Dlx proteins colocalize in the nuclei of the apical ectodermal ridge (AER). In homozygous p63 super(-) (null) and p63 super(EEC) (R279H) mutant limbs, the AER fails to stratify and the expression of four Dlx genes is strongly reduced; interestingly, the p63 super(+/EEC) and p63 super(+/-) hindlimbs, which develop normally and have a normally stratified AER, show reduced Dlx gene expression. The p63 super(+/EEC) mutation combined with an incomplete loss of Dlx5 and Dlx6 alleles leads to severe limb phenotypes, which are not observed in mice with either mutation alone. In vitro, Delta Np63 alpha induces transcription from the Dlx5 and Dlx6 promoters, an activity abolished by EEC and SHFM-IV mutations, but not by Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) mutations. ChIP analysis shows that p63 is directly associated with the Dlx5 and Dlx6 promoters. Thus, our data strongly implicate p63 and the Dlx5-Dlx6 locus in a pathway relevant in the aetio-pathogenesis of SHFM. JF - Development AU - Lo Iacono, Nadia AU - Mantero, Stefano AU - Chiarelli, Anna AU - Garcia, Elvin AU - Mills, Alea A AU - Morasso, Maria I AU - Costanzo, Antonio AU - Levi, Giovanni AU - Guerrini, Luisa AU - Merlo, Giorgio R AD - Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy. Department of Biomolecular Science and Biotechnology, University of Milan, Via Celoria 26, 20133 Milan, Italy. CNR Istituto Tecnologie Biomediche, Segrate Milano, Italy. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA. Developmental Skin Biology Unit, NIAMS, NIH, Bethesda, MD, USA. Department of Dermatology, University of Rome, TorVergata, Italy. Evolution des Regulations Endocriniennes CNRS, UMR5166, Museum National d'Histoire Naturelle, Paris, France Y1 - 2008/04/01/ PY - 2008 DA - 2008 Apr 01 SP - 1377 EP - 1388 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK, [URL:http://www.biologists.com/web/index.html] VL - 135 IS - 7 SN - 0950-1991, 0950-1991 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Dlx6 protein KW - Data processing KW - Hand KW - Palate KW - Dlx protein KW - Finger KW - Cleft lip/palate KW - Promoters KW - Lip KW - Limbs KW - Transcription factors KW - Ectrodactyly KW - Congenital defects KW - Nuclei KW - Mutation KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development&rft.atitle=Regulation+of+Dlx5+and+Dlx6+gene+expression+by+p63+is+involved+in+EEC+and+SHFM+congenital+limb+defects&rft.au=Lo+Iacono%2C+Nadia%3BMantero%2C+Stefano%3BChiarelli%2C+Anna%3BGarcia%2C+Elvin%3BMills%2C+Alea+A%3BMorasso%2C+Maria+I%3BCostanzo%2C+Antonio%3BLevi%2C+Giovanni%3BGuerrini%2C+Luisa%3BMerlo%2C+Giorgio+R&rft.aulast=Lo+Iacono&rft.aufirst=Nadia&rft.date=2008-04-01&rft.volume=135&rft.issue=7&rft.spage=1377&rft.isbn=&rft.btitle=&rft.title=Development&rft.issn=09501991&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dlx6 protein; Data processing; Hand; Palate; Dlx protein; Cleft lip/palate; Finger; Promoters; Limbs; Lip; Transcription factors; Ectrodactyly; Congenital defects; Nuclei; Mutation ER - TY - JOUR T1 - Complementary roles for histone deacetylases 1, 2, and 3 in differentiation of pluripotent stem cells AN - 19709044; 8223206 AB - In eukaryotic cells, covalent modifications to core histones contribute to the establishment and maintenance of cellular phenotype via regulation of gene expression. Histone acetyltransferases (HATs) cooperate with histone deacetylases (HDACs) to establish and maintain specific patterns of histone acetylation. HDAC inhibitors can cause pluripotent stem cells to cease proliferating and enter terminal differentiation pathways in culture. To better define the roles of individual HDACs in stem cell differentiation, we have constructed 'dominant-negative' stem cell lines expressing mutant, Flag-tagged HDACs with reduced enzymatic activity. Replacement of a single residue (His arrow right Ala) in the catalytic center reduced the activity of HDACs 1 and 2 by 80%, and abolished HDAC3 activity; the mutant HDACs were expressed at similar levels and in the same multiprotein complexes as wild-type HDACs. Hexamethylene bisacetamide-induced MEL cell differentiation was potentiated by the individual mutant HDACs, but only to 2%, versus 60% for an HDAC inhibitor, sodium butyrate, suggesting that inhibition of multiple HDACs is required for full potentiation. Cultured E14.5 cortical stem cells differentiate to neurons, astrocytes, and oligodendrocytes upon withdrawal of basic fibroblast growth factor. Transduction of stem cells with mutant HDACs 1, 2, or 3 shifted cell fate choice toward oligodendrocytes. Mutant HDAC2 also increased differentiation to astrocytes, while mutant HDAC1 reduced differentiation to neurons by 50%. These results indicate that HDAC activity inhibits differentiation to oligodendrocytes, and that HDAC2 activity specifically inhibits differentiation to astrocytes, while HDAC1 activity is required for differentiation to neurons. JF - Differentiation AU - Humphrey, Glen W AU - Wang, Yong-Hong AU - Hirai, Tazuko AU - Padmanabhan, Raji AU - Panchision, David M AU - Newell, Laura F AU - McKay, Ronald DG AU - Howard, Bruce H AD - Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA, howard@helix.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 348 EP - 356 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 76 IS - 4 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - HDAC KW - dominant negative KW - transduction KW - cell fate KW - MEL KW - neural stem cell KW - Histone deacetylase KW - Astrocytes KW - Oligodendrocytes KW - Potentiation KW - Histone acetyltransferase KW - Cell culture KW - Gene expression KW - Acetylation KW - Differentiation KW - Stem cells KW - HDAC2 protein KW - Neurons KW - Sodium butyrate KW - Cell fate KW - Enzymatic activity KW - Fibroblast growth factor 2 KW - N 14820:DNA Metabolism & Structure KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19709044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Differentiation&rft.atitle=Complementary+roles+for+histone+deacetylases+1%2C+2%2C+and+3+in+differentiation+of+pluripotent+stem+cells&rft.au=Humphrey%2C+Glen+W%3BWang%2C+Yong-Hong%3BHirai%2C+Tazuko%3BPadmanabhan%2C+Raji%3BPanchision%2C+David+M%3BNewell%2C+Laura+F%3BMcKay%2C+Ronald+DG%3BHoward%2C+Bruce+H&rft.aulast=Humphrey&rft.aufirst=Glen&rft.date=2008-04-01&rft.volume=76&rft.issue=4&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Differentiation&rft.issn=1432-0436&rft_id=info:doi/10.1111%2Fj.1432-0436.2007.00232.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Oligodendrocytes; Astrocytes; Histone acetyltransferase; Potentiation; Cell culture; Gene expression; Differentiation; Acetylation; Stem cells; HDAC2 protein; Neurons; Sodium butyrate; Enzymatic activity; Cell fate; Fibroblast growth factor 2 DO - http://dx.doi.org/10.1111/j.1432-0436.2007.00232.x ER - TY - JOUR T1 - Simultaneous measurements of fast optical and proton current kinetics in the bacteriorhodopsin photocycle using an enhanced spectrophotometer AN - 19650610; 8548527 AB - A one-of-a-kind high speed optical multichannel spectrometer was designed and built at NIH and described in this journal in 1997 [J.W. Cole, R.W. Hendler, P.D. Smith, H.A. Fredrickson, T.J. Pohida, W.S. Friauf. A high speed optical multichannel analyzer. J Biochem Biophys Methods 1997; 35:16-174.]. The most unique aspect of this instrument was the ability to follow an entire time course from a single activation using a single sample. The instrument has been used to study rapid kinetic processes in the photon-driven bacteriorhodopsin photocycle and electron transport from cytochrome c to cytochrome aa3 and from cytochrome aa3 to oxygen. The present paper describes a second generation instrument with a number of important enhancements which significantly improve its capabilities for multichannel kinetic studies. An example application is presented in which the kinetics of photon-induced proton flow across the biological membrane is measured simultaneously with the individual steps of the photocycle determined optically. Matching the time constants for the two processes indicates which molecular transformations are associated with major proton movements. JF - Journal of Biochemical and Biophysical Methods AU - Kakareka, John W AU - Smith, Paul D AU - Pohida, Thomas J AU - Hendler, Richard W AD - Division of Computational Bioscience, Center for Information Technology, Bethesda, Maryland, 20892, United States, rwh@helix.nih.gov Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 1116 EP - 1123 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com] VL - 70 IS - 6 SN - 0165-022X, 0165-022X KW - Bacteria KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources KW - High speed spectrophotometer KW - Rapid kinetics KW - Bacteriorhodopsin photocycle KW - Proton pump KW - Energy transduction KW - Transformation KW - Cytochromes KW - Photocycles KW - Biochemistry KW - Protons KW - Cytochrome-c oxidase KW - Biological membranes KW - Oxygen KW - Cytochrome c KW - Bacteriorhodopsin KW - Kinetics KW - Microorganisms KW - Electron transport KW - Spectrophotometers KW - Q1 08206:Physiology, biochemistry, biophysics KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19650610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biochemical+and+Biophysical+Methods&rft.atitle=Simultaneous+measurements+of+fast+optical+and+proton+current+kinetics+in+the+bacteriorhodopsin+photocycle+using+an+enhanced+spectrophotometer&rft.au=Kakareka%2C+John+W%3BSmith%2C+Paul+D%3BPohida%2C+Thomas+J%3BHendler%2C+Richard+W&rft.aulast=Kakareka&rft.aufirst=John&rft.date=2008-04-01&rft.volume=70&rft.issue=6&rft.spage=1116&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biochemical+and+Biophysical+Methods&rft.issn=0165022X&rft_id=info:doi/10.1016%2Fj.jprot.2007.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Cytochromes; Biochemistry; Microorganisms; Biological membranes; Spectrophotometers; Transformation; Oxygen; Cytochrome c; Photocycles; Bacteriorhodopsin; Protons; Kinetics; Cytochrome-c oxidase; Electron transport; Bacteria DO - http://dx.doi.org/10.1016/j.jprot.2007.11.004 ER - TY - JOUR T1 - 17- beta -Estradiol in relation to age at menarche and adult obesity in premenopausal women AN - 19602525; 8086038 AB - BACKGROUND: We hypothesize that premenopausal endogenous estradiol may be associated with age at menarche and adult overweight and obesity, potentially contributing to breast cancer risk. METHODS: We assessed age at menarche by questionnaire among 204 healthy Norwegian women, aged 25-35 years. Measures of body composition included body mass index (BMI, kg/m super(2)), waist circumference (WC, cm), waist-to-hip ratio (WHR) and fat percentage dual energy X-ray absorptiometry, (DEXA). Daily salivary 17- beta -estradiol (E sub(2)) concentrations were collected throughout one entire menstrual cycle and assessed by radioimmunoassay (RIA). Linear regression analyses and linear mixed models for repeated measures were used and potential confounding factors and effect modifiers were tested. RESULTS: Among women with an early age at menarche ( less than or equal to 12 years), the overall mean salivary E sub(2) concentration increased by 3.7 pmol/l (95% confidence interval, 1.8-5.7 pmol/l) with each 9.8 cm (1 SD) increase in WC, which represents a 20.7% change in the mean for the total group. Among the same early maturers, a 1 SD (0.06) change in WHR was directly associated with a 24.0% change in mean E sub(2) concentration for the total group. CONCLUSIONS: Our findings support the hypothesis that early age at menarche, together with adult overweight and obesity, result in high levels of 17- beta -estradiol throughout the menstrual cycle. JF - Human Reproduction AU - Emaus, A AU - Espetvedt, S AU - Veieroed, M B AU - Ballard-Barbash, R AU - Furberg, A-S AU - Ellison, P T AU - Jasienska, G AU - Hjartaaker, A AU - Thune, I AD - Department of Oncology, Ullevaal University Hospital, 0407 Oslo, Norway. Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway. Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, EPN 4005, 6130 Executive Boulevard, MSC 7344, Bethesda, MD 20892-7344, USA. NORM Surveillance Program for Antimicrobial Resistance in Human Pathogens, Department of Microbiology and Infection Control, University Hospital of North Norway, N-9038 Tromsoe, Norway. Institute of Community Medicine, Faculty of Medicine, University of Tromsoe, N-9037 Tromsoe, Norway. Department of Anthropology, Harvard University, 11 Divinity Avenue, Cambridge, MA 02138, USA. Department of Epidemiology and Population Studies, Jagiellonian University, Collegium Medicum, Krakow, Poland. Institute of Population-Based Cancer Research, Cancer Registry of Norway, Montebello, N-0310 Oslo, Norway. The Research Council of Norway, PO Box 2700, St Hanshaugen, Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 919 EP - 927 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 4 SN - 0268-1161, 0268-1161 KW - Sustainability Science Abstracts KW - Age KW - obesity KW - Cancer KW - body mass KW - Breast cancer KW - Reproduction KW - Females KW - Norway KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=17-+beta+-Estradiol+in+relation+to+age+at+menarche+and+adult+obesity+in+premenopausal+women&rft.au=Emaus%2C+A%3BEspetvedt%2C+S%3BVeieroed%2C+M+B%3BBallard-Barbash%2C+R%3BFurberg%2C+A-S%3BEllison%2C+P+T%3BJasienska%2C+G%3BHjartaaker%2C+A%3BThune%2C+I&rft.aulast=Emaus&rft.aufirst=A&rft.date=2008-04-01&rft.volume=23&rft.issue=4&rft.spage=919&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Norway; Age; obesity; Reproduction; Females; Cancer; body mass; Breast cancer ER - TY - JOUR T1 - Obesity and Functional Disability in Elderly Americans AN - 19601570; 8225090 AB - OBJECTIVESTo investigate whether indicators of obesity are associated with functional disabilities in elderly American women and men. DESIGNCross-sectional. SETTINGNational Health and Nutrition Examination Survey (NHANES) 1999 to 2004, United States. PARTICIPANTSOne thousand six hundred eighty-four elderly (aged greater than or equal to 60) women and 1,611 elderly men. MEASUREMENTSFunctional disabilities. RESULTSIn women, body mass index (BMI) and waist circumference were each related to higher prevalence of all measures of disabilities. Compared with the lowest quartile of waist circumference, the multivariate odds ratios (ORs) of the highest quartile for having difficulties in functional domains were 2.4 (95% confidence interval (CI)=1.6-3.6) for activities of daily living, 2.3 (95% CI=1.6-3.3) for instrumental activities of daily living, 2.6 (95% CI=1.6-4.1) for leisure and social activities, 4.8 (95% CI=3.4-6.9) for lower extremity mobility, and 2.9 (95% CI=2.1-4.0) for general physical activity. In men, these associations were moderate; the corresponding ORs were 1.2 (95% CI=0.8-2.0), 1.3 (95% CI=0.9-2.1), 2.1 (95% CI=1.2-3.7), 1.8 (95% CI=1.2-2.7), and 2.1 (95% CI=1.5-2.8), respectively. Similar results were obtained for BMI. These associations could not be explained by the presence of major chronic conditions. When adjusted simultaneously, waist circumference appeared to be a better predictor than BMI of disability in women. CONCLUSIONThe results suggest that indicators of obesity are related to functional disabilities in elderly Americans. JF - Journal of the American Geriatrics Society AU - Chen, Honglei AU - Guo, Xuguang AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, chenh2@niehs.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 689 EP - 694 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 56 IS - 4 KW - Risk Abstracts KW - Mobility KW - disabilities KW - obesity KW - extremities KW - Nutrition KW - USA KW - body mass KW - physical activity KW - elderly KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19601570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Obesity+and+Functional+Disability+in+Elderly+Americans&rft.au=Chen%2C+Honglei%3BGuo%2C+Xuguang&rft.aulast=Chen&rft.aufirst=Honglei&rft.date=2008-04-01&rft.volume=56&rft.issue=4&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=1532-5415&rft_id=info:doi/10.1111%2Fj.1532-5415.2007.01624.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; disabilities; elderly; obesity; physical activity; Nutrition; Mobility; extremities; body mass DO - http://dx.doi.org/10.1111/j.1532-5415.2007.01624.x ER - TY - JOUR T1 - Abrogation of Anti-Retinal Autoimmunity in IL-10 Transgenic Mice Due to Reduced T Cell Priming and Inhibition of Disease Effector Mechanisms AN - 19531161; 8200960 AB - Experimental autoimmune uveitis (EAU) induced by immunization of animals with retinal Ags is a model for human uveitis. The immunosuppressive cytokine IL-10 regulates EAU susceptibility and may be a factor in genetic resistance to EAU. To further elucidate the regulatory role of endogenous IL-10 in the mouse model of EAU, we examined transgenic (Tg) mice expressing IL-10 either in activated T cells (inducible) or in macrophages (constitutive). These IL-10-Tg mice and non-Tg wild-type controls were immunized with a uveitogenic regimen of the retinal Ag interphotoreceptor retinoid-binding protein. Constitutive expression of IL-10 in macrophages abrogated disease and reduced Ag-specific immunological responses. These mice had detectable levels of IL-10 in sera and in ocular extracts. In contrast, expression of IL-10 in activated T cells only partially protected from EAU and marginally reduced Ag-specific responses. All IL-10-Tg lines showed suppression of Ag-specific effector cytokines. APC from Tg mice constitutively expressing IL-10 in macrophages exhibited decreased ability to prime naive T cells, however, Ag presentation to already primed T cells was not compromised. Importantly, IL-10-Tg mice that received interphotoreceptor retinoid-binding protein-specific uveitogenic T cells from wild-type donors were protected from EAU. We suggest that constitutively produced endogenous IL-10 ameliorates the development of EAU by suppressing de novo priming of Ag-specific T cells and inhibiting the recruitment and/or function of inflammatory leukocytes, rather than by inhibiting local Ag presentation within the eye. JF - Journal of Immunology AU - Agarwal, Rajeev K AU - Horai, Reiko AU - Viley, Angelia M AU - Silver, Phyllis B AU - Grajewski, Rafael S AU - Bo Su, Shao AU - Yazdani, Arrash T AU - Zhu, Wei AU - Kronenberg, Mitchell AU - Murray, Peter J AU - Rutschman, Robert L AU - Chan, Chi-Chao AU - Caspi, Rachel R AD - The Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892. La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037. Department of Infectious Diseases, St. Jude Children's Hospital, Memphis, TN 38105 Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 5423 EP - 5429 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 8 SN - 0022-1767, 0022-1767 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Macrophages KW - Eye KW - Retina KW - Autoimmune diseases KW - Leukocytes KW - Animal models KW - Transgenic mice KW - Antigen presentation KW - Interleukin 10 KW - Immunization KW - Inflammation KW - interphotoreceptor retinoid-binding protein KW - Uveitis KW - experimental autoimmune uveitis KW - Lymphocytes T KW - Antigen-presenting cells KW - Experimental autoimmune uveoretinitis KW - W 30925:Genetic Engineering KW - F 06930:Autoimmunity KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19531161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Abrogation+of+Anti-Retinal+Autoimmunity+in+IL-10+Transgenic+Mice+Due+to+Reduced+T+Cell+Priming+and+Inhibition+of+Disease+Effector+Mechanisms&rft.au=Agarwal%2C+Rajeev+K%3BHorai%2C+Reiko%3BViley%2C+Angelia+M%3BSilver%2C+Phyllis+B%3BGrajewski%2C+Rafael+S%3BBo+Su%2C+Shao%3BYazdani%2C+Arrash+T%3BZhu%2C+Wei%3BKronenberg%2C+Mitchell%3BMurray%2C+Peter+J%3BRutschman%2C+Robert+L%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel+R&rft.aulast=Agarwal&rft.aufirst=Rajeev&rft.date=2008-04-01&rft.volume=180&rft.issue=8&rft.spage=5423&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Retina; Eye; Leukocytes; Autoimmune diseases; Animal models; Antigen presentation; Transgenic mice; Immunization; Interleukin 10; Inflammation; Uveitis; interphotoreceptor retinoid-binding protein; experimental autoimmune uveitis; Lymphocytes T; Antigen-presenting cells; Experimental autoimmune uveoretinitis ER - TY - JOUR T1 - Bombesin marine toxin conjugates inhibit the growth of lung cancer cells AN - 19512406; 8838256 AB - Hemiasterlin (Hem) and dolastatin (Dol) are marine natural products which are cytotoxic for cancer cells. Hem, a tripeptide, and Dol, a hexapeptide, were conjugated with linkers (L) to the universal BB agonist DPhe-Gln-Trp- Ala-Val- beta Ala-His-Phe-Nle-NH sub(2)(BA1) and the effects of the Hem-BB and Dol- BB conjugates investigated on NCI-H1299 lung cancer cells. Hem-LA-BA1 and Hem-LB-BA1 inhibited specific ( super(125)I-Tyr super(4))BB binding to NCI-H1299 cells, which have BB sub(2) receptors (R), with IC sub(50) values of 15 and 25 nM, respectively. Addition of Hem-LA-BA1 and Hem-LB-BA1 to Fura-2 AM loaded cells containing BB sub(2)R, caused elevated cytosolic Ca super(2+). In a growth assay, Hem-LA-BA1 and Hem-LB-BA1 inhibited the proliferation of NCI-H1299 cells. Dol-succinamide (Dols)-LD-BA1 and Dols-LE-BA1 bound with high affinity to NCI-H1299 cells and elevated cytosolic Ca super(2+), but did not inhibit the proliferation of NCI-H1299 cells. Also, Hem-LA-BA1 inhibited super(125)I-DTyr- Gln-Trp-Ala-Val- beta Ala-His-Phe-Nle-NH sub(2) (BA2) binding to Balb/3T3 cells transfected with BB sub(1)R or BB sub(2)R as well as with BRS-3 with IC sub(50) values of 130, 8, and 540 nM, respectively. These results show that Hem-BB conjugates are cytotoxic for cancer cells containing BB sub(2)R. JF - Life Sciences AU - Moody, Terry W AU - Pradhan, Tapas AU - Mantey, Samuel A AU - Jensen, Robert T AU - Dyba, Marcin AU - Moody, Deborah AU - Tarasova, Nadya I AU - Michejda, Christopher J AD - Department of Health and Human Services, NCI Office of the Director, CCR, Bethesda, MD 20892 USA, moodyt@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 855 EP - 861 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 82 IS - 15-16 SN - 0024-3205, 0024-3205 KW - Toxicology Abstracts; Calcium & Calcified Tissue Abstracts; ASFA Marine Biotechnology Abstracts KW - Bombesin KW - Dolastatin KW - Hemiasterlin KW - Lung cancer KW - Cytotoxicity KW - Calcium KW - Fura-2 KW - natural products KW - Cell proliferation KW - Toxins KW - T 2000:Cellular Calcium KW - Q4 27700:Molecular Techniques KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19512406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+Sciences&rft.atitle=Bombesin+marine+toxin+conjugates+inhibit+the+growth+of+lung+cancer+cells&rft.au=Moody%2C+Terry+W%3BPradhan%2C+Tapas%3BMantey%2C+Samuel+A%3BJensen%2C+Robert+T%3BDyba%2C+Marcin%3BMoody%2C+Deborah%3BTarasova%2C+Nadya+I%3BMichejda%2C+Christopher+J&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2008-04-01&rft.volume=82&rft.issue=15-16&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Life+Sciences&rft.issn=00243205&rft_id=info:doi/10.1016%2Fj.lfs.2008.01.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Calcium; Bombesin; Fura-2; natural products; Cell proliferation; Toxins; Lung cancer DO - http://dx.doi.org/10.1016/j.lfs.2008.01.019 ER - TY - JOUR T1 - Ultrasound-Detected Thyroid Nodule Prevalence and Radiation Dose from Fallout AN - 19500199; 8693539 AB - Land, C. E., Zhumadilov, Z., Gusev, B. I., Hartshorne, M. H., Wiest, P. W., Woodward, P. W., Crooks, L. A., Luckyanov, N. K., Fillmore, C. M., Carr, Z., Abisheva, G., Beck, H. L., Bouville, A., Langer, J., Weinstock, R., Gordeev, K. I., Shinkarev, S. M. and Simon, S. L. Ultrasound-Detected Thyroid Nodule Prevalence and Radiation Dose from Fallout. Radiat. Res. 169, 373-383 (2008). Settlements near the Semipalatinsk Test Site (SNTS) in northeastern Kazakhstan were exposed to radioactive fallout during 1949-1962. Thyroid disease prevalence among 2994 residents of eight villages was ascertained by ultrasound screening. Malignancy was determined by cytopathology. Individual thyroid doses from external and internal radiation sources were reconstructed from fallout deposition patterns, residential histories and diet, including childhood milk consumption. Point estimates of individual external and internal dose averaged 0.04 Gy (range 0-0.65) and 0.31 Gy (0-9.6), respectively, with a Pearson correlation coefficient of 0.46. Ultrasound-detected thyroid nodule prevalence was 18% and 39% among males and females, respectively. It was significantly and independently associated with both external and internal dose, the main study finding. The estimated relative biological effectiveness of internal compared to external radiation dose was 0.33, with 95% confidence bounds of 0.09-3.11. Prevalence of papillary cancer was 0.9% and was not significantly associated with radiation dose. In terms of excess relative risk per unit dose, our dose-response findings for nodule prevalence are comparable to those from populations exposed to medical X rays and to acute radiation from the Hiroshima and Nagasaki atomic bombings. JF - Radiation Research AU - Land, CE AU - Zhumadilov, Z AU - Gusev, B I AU - Hartshorne, M H AU - Wiest, P W AU - Woodward, P W AU - Crooks, LA AU - Luckyanov, N K AU - Fillmore, C M AU - Carr, Z AU - Abisheva, G AU - Beck, H L AU - Bouville, A AU - Langer, J AU - Weinstock, R AU - Gordeev, KI AU - Shinkarev, S AU - Simon, S L AD - National Cancer Institute, Division of Cancer Epidemiology and Genetics, landc@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 373 EP - 383 PB - Allen Press, Inc., 810 East Tenth St. VL - 169 IS - 4 SN - 0033-7587, 0033-7587 KW - Biotechnology and Bioengineering Abstracts; Toxicology Abstracts KW - Fallout KW - Diets KW - Risk assessment KW - Malignancy KW - Milk KW - thyroid diseases KW - Children KW - Ultrasound KW - Nodules KW - Cancer KW - X 24390:Radioactive Materials KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19500199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Ultrasound-Detected+Thyroid+Nodule+Prevalence+and+Radiation+Dose+from+Fallout&rft.au=Land%2C+CE%3BZhumadilov%2C+Z%3BGusev%2C+B+I%3BHartshorne%2C+M+H%3BWiest%2C+P+W%3BWoodward%2C+P+W%3BCrooks%2C+LA%3BLuckyanov%2C+N+K%3BFillmore%2C+C+M%3BCarr%2C+Z%3BAbisheva%2C+G%3BBeck%2C+H+L%3BBouville%2C+A%3BLanger%2C+J%3BWeinstock%2C+R%3BGordeev%2C+KI%3BShinkarev%2C+S%3BSimon%2C+S+L&rft.aulast=Land&rft.aufirst=CE&rft.date=2008-04-01&rft.volume=169&rft.issue=4&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1063.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Diets; Fallout; Malignancy; Milk; thyroid diseases; Children; Ultrasound; Cancer; Nodules DO - http://dx.doi.org/10.1667/RR1063.1 ER - TY - JOUR T1 - An integrated view of L-selectin and trophinin function in human embryo implantation AN - 19481334; 8225458 AB - Determining molecular mechanisms of human embryo implantation is an extremely challenging task due to the limitation of materials and significant differences underlying this process among mammalian species. Recently, L-selectin and its ligand carbohydrate have been proposed as a system that mediates initial adhesion of human blastocysts to the uterine epithelia. We have also identified trophinin as a unique apical cell adhesion molecule potentially involved in the initial adhesion of trophectoderm of the human blastocyst to endometrial surface epithelia. In the mouse, the binding between ErbB4 on the blastocyst and heparin-binding epidermal growth factor-like growth factor on the endometrial surface enables the initial step of the blastocyst implantation. The evidence suggests that L-selectin and trophinin are included in human embryo implantation. This review summarizes findings relevant to the functions of L-selectin and trophinin in human embryo implantation, and proposes a model that reconciles these cell adhesion mechanisms. JF - Journal of Obstetrics and Gynaecology Research AU - Fukuda, Michiko N AU - Sugihara, Kazuhiro AD - Glycobiology Unit, Tumor Microenvironment Program, NCI Cancer Center, Burnham Institute for Medical Research, La Jolla, California, USA; and, michiko@burnham.org Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 129 EP - 136 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 34 IS - 2 KW - Biotechnology and Bioengineering Abstracts KW - Heparin-binding epidermal growth factor-like growth factor KW - Molecular modelling KW - Endometrium KW - Uterus KW - ErbB-2 protein KW - trophectoderm KW - Cell adhesion KW - blastocysts KW - Reviews KW - L-selectin KW - Embryos KW - Carbohydrates KW - Obstetrics KW - Cell adhesion molecules KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19481334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Obstetrics+and+Gynaecology+Research&rft.atitle=An+integrated+view+of+L-selectin+and+trophinin+function+in+human+embryo+implantation&rft.au=Fukuda%2C+Michiko+N%3BSugihara%2C+Kazuhiro&rft.aulast=Fukuda&rft.aufirst=Michiko&rft.date=2008-04-01&rft.volume=34&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Journal+of+Obstetrics+and+Gynaecology+Research&rft.issn=1447-0756&rft_id=info:doi/10.1111%2Fj.1447-0756.2008.00776.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heparin-binding epidermal growth factor-like growth factor; Molecular modelling; Uterus; Endometrium; ErbB-2 protein; trophectoderm; Cell adhesion; blastocysts; Reviews; L-selectin; Embryos; Carbohydrates; Obstetrics; Cell adhesion molecules DO - http://dx.doi.org/10.1111/j.1447-0756.2008.00776.x ER - TY - JOUR T1 - Review of factors essential for blastocyst implantation for their modulating effects on the maternal immune system AN - 19474393; 8093443 AB - Pituitary and ovarian hormones prepare the endometrium for successful blastocyst implantation and support its process directly or indirectly through the action of growth factors, cytokines and other molecules. Many of the blastocyst implantation essential factors (BIEFs) are modulators of the maternal immune system. Since little is known as to the action of these molecules on the uterine lymphocytes, its clarification is imperative to the understanding of the process of blastocyst implantation. JF - Seminars in Cell & Developmental Biology AU - Yoshinaga, K AD - Center for Population Research, National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, MD 20892-7510, USA, ky6a@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 161 EP - 169 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 19 IS - 2 SN - 1084-9521, 1084-9521 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - blastocysts KW - Endometrium KW - Uterus KW - Pituitary KW - Immune system KW - Reviews KW - Cytokines KW - Lymphocytes KW - Growth factors KW - Hormones KW - W 30940:Products KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19474393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Cell+%26+Developmental+Biology&rft.atitle=Review+of+factors+essential+for+blastocyst+implantation+for+their+modulating+effects+on+the+maternal+immune+system&rft.au=Yoshinaga%2C+K&rft.aulast=Yoshinaga&rft.aufirst=K&rft.date=2008-04-01&rft.volume=19&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Cell+%26+Developmental+Biology&rft.issn=10849521&rft_id=info:doi/10.1016%2Fj.semcdb.2007.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Uterus; Endometrium; blastocysts; Pituitary; Reviews; Immune system; Cytokines; Growth factors; Lymphocytes; Hormones DO - http://dx.doi.org/10.1016/j.semcdb.2007.10.006 ER - TY - JOUR T1 - The Teen Brain: Insights from Neuroimaging AN - 19470402; 8116057 AB - Few parents of a teenager are surprised to hear that the brain of a 16-year-old is different from the brain of an 8-year-old. Yet to pin down these differences in a rigorous scientific way has been elusive. Magnetic resonance imaging, with the capacity to provide exquisitely accurate quantifications of brain anatomy and physiology without the use of ionizing radiation, has launched a new era of adolescent neuroscience. Longitudinal studies of subjects from ages 3-30 years demonstrate a general pattern of childhood peaks of gray matter followed by adolescent declines, functional and structural increases in connectivity and integrative processing, and a changing balance between limbic/cortical and frontal lobe functions, extending well into young adulthood. Although overinterpretation and premature application of neuroimaging findings for diagnostic purposes remains a risk, converging data from multiple imaging modalities is beginning to elucidate the implications of these brain changes on cognition, emotion, and behavior. JF - Journal of Adolescent Health AU - Giedd, Jay N AD - Brain Imaging Unit, Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, jg@nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 335 EP - 343 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 42 IS - 4 SN - 1054-139X, 1054-139X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Child KW - Adolescent KW - Development KW - MRI KW - DTI KW - MT KW - fMRI KW - Gray matter KW - White matter KW - Emotions KW - Age KW - Neuroimaging KW - Data processing KW - Neural networks KW - Adolescence KW - Magnetic resonance imaging KW - Children KW - Cognition KW - Frontal lobe KW - Structure-function relationships KW - Ionizing radiation KW - Substantia grisea KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19470402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=The+Teen+Brain%3A+Insights+from+Neuroimaging&rft.au=Giedd%2C+Jay+N&rft.aulast=Giedd&rft.aufirst=Jay&rft.date=2008-04-01&rft.volume=42&rft.issue=4&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2008.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Emotions; Neuroimaging; Age; Data processing; Neural networks; Adolescence; Magnetic resonance imaging; Children; Cognition; Structure-function relationships; Frontal lobe; Ionizing radiation; Substantia grisea DO - http://dx.doi.org/10.1016/j.jadohealth.2008.01.007 ER - TY - JOUR T1 - Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing AN - 19464511; 8112227 AB - The premature-ageing disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by constitutive production of progerin, a mutant form of the nuclear architectural protein lamin A super(2). Progerin is also expressed sporadically in wild-type cells and has been linked to physiological ageing super(3). Cells from HGPS patients exhibit extensive nuclear defects, including abnormal chromatin structure super(5) and increased DNA damage super(6). At the organismal level, HGPS affects several tissues, particularly those of mesenchymal origin super(7). How the cellular defects of HGPS cells lead to the organismal defects has been unclear. Here, we provide evidence that progerin interferes with the function of human mesenchymal stem cells (hMSCs). We find that expression of progerin activates major downstream effectors of the Notch signalling pathway. Induction of progerin in hMSCs changes their molecular identity and differentiation potential. Our results support a model in which accelerated ageing in HGPS patients, and possibly also physiological ageing, is the result of adult stem cell dysfunction and progressive deterioration of tissue functions. JF - Nature Cell Biology AU - Scaffidi, Paola AU - Misteli, Tom Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 452 EP - 459 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 10 IS - 4 SN - 1465-7392, 1465-7392 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Progeria KW - Notch protein KW - Differentiation KW - Stem cells KW - Chromatin KW - Aging KW - DNA KW - Lamins KW - Mesenchyme KW - Signal transduction KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Cell+Biology&rft.atitle=Lamin+A-dependent+misregulation+of+adult+stem+cells+associated+with+accelerated+ageing&rft.au=Scaffidi%2C+Paola%3BMisteli%2C+Tom&rft.aulast=Scaffidi&rft.aufirst=Paola&rft.date=2008-04-01&rft.volume=10&rft.issue=4&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=Nature+Cell+Biology&rft.issn=14657392&rft_id=info:doi/10.1038%2Fncb1708 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Notch protein; Progeria; Differentiation; Stem cells; Chromatin; Aging; DNA; Lamins; Mesenchyme; Signal transduction DO - http://dx.doi.org/10.1038/ncb1708 ER - TY - JOUR T1 - A novel bifunctional maleimido CHX-A" chelator for conjugation to thiol- containing biomolecules AN - 19332363; 8685586 AB - A novel bifunctional maleimido CHX-A" DTPA chelator 5 was developed and conjugated to the monoclonal antibody trastuzumab (Herceptin) and subsequently radiolabeled with super(111)In. The resulting super(111)In labeled immunoconjugate 2 was demonstrated to bind to SKOV-3 ovarian cancer cells comparably to an isothiocyanato CHX-A" DTPA modified native trastuzumab, 1. Through efficient thiol-maleimide chemistry, antibodies, peptides or other targeting vectors can now be modified with an established radioactive metal chelating agent CHX-A" DTPA for imaging and/or therapies of cancer. JF - Bioorganic and Medicinal Chemistry AU - Xu, Heng AU - Baidoo, Kwamena E AU - Wong, Karen J AU - Brechbiel, Martin W AD - Radioimmune & Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 1B40, 10 Center Drive, Bethesda, MD 20892-1088, USA, martinwb@mail.nih.gov Y1 - 2008/04// PY - 2008 DA - Apr 2008 SP - 2679 EP - 2683 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 8 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Metals KW - Ovarian cancer KW - Monoclonal antibodies KW - Chelating agents KW - trastuzumab KW - imaging KW - Immunoconjugates KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19332363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=A+novel+bifunctional+maleimido+CHX-A%22+chelator+for+conjugation+to+thiol-+containing+biomolecules&rft.au=Xu%2C+Heng%3BBaidoo%2C+Kwamena+E%3BWong%2C+Karen+J%3BBrechbiel%2C+Martin+W&rft.aulast=Xu&rft.aufirst=Heng&rft.date=2008-04-01&rft.volume=18&rft.issue=8&rft.spage=2679&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2008.03.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Metals; Monoclonal antibodies; trastuzumab; Chelating agents; imaging; Immunoconjugates DO - http://dx.doi.org/10.1016/j.bmcl.2008.03.022 ER - TY - JOUR T1 - Microarray design for microbial monitoring and space exploration AN - 1220563386; 2013-001396 JF - Astrobiology AU - Starke, Verena AU - Bilke, Sven AU - Monaco, Lisa AU - Flores, Ginger AU - Steele, Andrew AU - Anbar, Ariel D AU - DeVore, Edna Y1 - 2008/04// PY - 2008 DA - April 2008 SP - 300 PB - Mary Ann Liebert, Larchmont, NY VL - 8 IS - 2 SN - 1531-1074, 1531-1074 KW - methods KW - monitoring KW - eukaryotes KW - Archaea KW - exploration KW - nucleic acids KW - RNA KW - identification KW - bacteria KW - DNA KW - algorithms KW - instruments KW - microorganisms KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1220563386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Astrobiology&rft.atitle=Microarray+design+for+microbial+monitoring+and+space+exploration&rft.au=Starke%2C+Verena%3BBilke%2C+Sven%3BMonaco%2C+Lisa%3BFlores%2C+Ginger%3BSteele%2C+Andrew%3BAnbar%2C+Ariel+D%3BDeVore%2C+Edna&rft.aulast=Starke&rft.aufirst=Verena&rft.date=2008-04-01&rft.volume=8&rft.issue=2&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Astrobiology&rft.issn=15311074&rft_id=info:doi/ L2 - http://www.liebertpub.com/publication.aspx?pub_id=99 LA - English DB - GeoRef N1 - Conference title - Fifth astrobiology science conference N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2013-01-01 N1 - PubXState - NY N1 - Last updated - 2012-11-29 N1 - SubjectsTermNotLitGenreText - algorithms; Archaea; bacteria; DNA; eukaryotes; exploration; identification; instruments; methods; microorganisms; monitoring; nucleic acids; RNA ER - TY - CPAPER T1 - Estrogen Receptor Action In Vivo T2 - 2008 Keystone Symposia on Nuclear Receptors: Steroid Sisters (Z2) AN - 40823321; 4802673 JF - 2008 Keystone Symposia on Nuclear Receptors: Steroid Sisters (Z2) AU - Korach, Kenneth S Y1 - 2008/03/30/ PY - 2008 DA - 2008 Mar 30 KW - Estrogen receptors KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40823321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28Z2%29&rft.atitle=Estrogen+Receptor+Action+In+Vivo&rft.au=Korach%2C+Kenneth+S&rft.aulast=Korach&rft.aufirst=Kenneth&rft.date=2008-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulating Nuclear Receptors with Chromatin T2 - 2008 Keystone Symposia on Nuclear Receptors: Steroid Sisters (Z2) AN - 40823124; 4802651 JF - 2008 Keystone Symposia on Nuclear Receptors: Steroid Sisters (Z2) AU - Archer, Trevor K Y1 - 2008/03/30/ PY - 2008 DA - 2008 Mar 30 KW - Nuclear receptors KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40823124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28Z2%29&rft.atitle=Regulating+Nuclear+Receptors+with+Chromatin&rft.au=Archer%2C+Trevor+K&rft.aulast=Archer&rft.aufirst=Trevor&rft.date=2008-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nuclear Receptor Signaling Atlas (Nursa): A Resource for the NR Community T2 - 2008 Keystone Symposia on Nuclear Receptors: Orphan Brothers (Z1) AN - 40822826; 4802594 JF - 2008 Keystone Symposia on Nuclear Receptors: Orphan Brothers (Z1) AU - Margolis, Ronald N Y1 - 2008/03/30/ PY - 2008 DA - 2008 Mar 30 KW - Signal transduction KW - Nuclear receptors KW - Atlases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40822826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Nuclear+Receptors%3A+Orphan+Brothers+%28Z1%29&rft.atitle=The+Nuclear+Receptor+Signaling+Atlas+%28Nursa%29%3A+A+Resource+for+the+NR+Community&rft.au=Margolis%2C+Ronald+N&rft.aulast=Margolis&rft.aufirst=Ronald&rft.date=2008-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Nuclear+Receptors%3A+Orphan+Brothers+%28Z1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=95 6&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glucocorticoid Receptor Dynamics and Global Chromatin Structure T2 - 2008 Keystone Symposia on Nuclear Receptors: Steroid Sisters (Z2) AN - 40821118; 4802646 JF - 2008 Keystone Symposia on Nuclear Receptors: Steroid Sisters (Z2) AU - Hager, Gordon L Y1 - 2008/03/30/ PY - 2008 DA - 2008 Mar 30 KW - Chromatin KW - Glucocorticoid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40821118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28Z2%29&rft.atitle=Glucocorticoid+Receptor+Dynamics+and+Global+Chromatin+Structure&rft.au=Hager%2C+Gordon+L&rft.aulast=Hager&rft.aufirst=Gordon&rft.date=2008-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Nuclear+Receptors%3A+Steroid+Sisters+%28Z2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sirtuins as Regulators of Mitochondrial Function T2 - 2008 Keystone symposia on Metabolic Pathways of Longevity (G1) AN - 40807866; 4802448 JF - 2008 Keystone symposia on Metabolic Pathways of Longevity (G1) AU - Finkel, Toren Y1 - 2008/03/30/ PY - 2008 DA - 2008 Mar 30 KW - Mitochondria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+symposia+on+Metabolic+Pathways+of+Longevity+%28G1%29&rft.atitle=Sirtuins+as+Regulators+of+Mitochondrial+Function&rft.au=Finkel%2C+Toren&rft.aulast=Finkel&rft.aufirst=Toren&rft.date=2008-03-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+symposia+on+Metabolic+Pathways+of+Longevity+%28G1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=92 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIGMS Supported Drug Docking and Screening Data Resource T2 - 2008 Keystone Symposia on Computer-Aided Drug Design (D1) AN - 40808744; 4802407 JF - 2008 Keystone Symposia on Computer-Aided Drug Design (D1) AU - Preusch, Peter C Y1 - 2008/03/29/ PY - 2008 DA - 2008 Mar 29 KW - Drugs KW - Drug screening KW - Screening KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40808744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Computer-Aided+Drug+Design+%28D1%29&rft.atitle=NIGMS+Supported+Drug+Docking+and+Screening+Data+Resource&rft.au=Preusch%2C+Peter+C&rft.aulast=Preusch&rft.aufirst=Peter&rft.date=2008-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Computer-Aided+Drug+Design+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 9&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. AN - 70423093; 18218630 AB - RFX4_v3 (regulatory factor X4 variant 3) is a brain-specific isoform of the transcription factor RFX4. Insertional mutagenesis in mice demonstrates that Rfx4_v3 is crucial for normal brain development. Many genes involved in critical processes during brain morphogenesis are dysregulated in Rfx4_v3 mutant brains. For example, Cx3cl1 is a CX3C-type chemokine that is abundant in brain and is a direct transcriptional target of RFX4_v3 through a specific promoter X-box (X-box 1), the responsive element for RFX proteins. To identify potential interacting partners for RFX4_v3, we performed yeast two-hybrid analysis. Nine candidate interactors were identified, including GPS2 (G-protein pathway suppressor 2). Indirect immunofluorescence demonstrated that GPS2 and RFX4_v3 co-localized to the nucleus. Both GPS2 and RFX4_v3 mRNAs were also present in most portions of the adult mouse brain as well as in brains at different ages, suggesting that the two proteins could bind to each other. Co-immunoprecipitation assays indicated that physical interactions between GPS2 and RFX4_v3 did indeed occur. Furthermore, GPS2 was recruited to the Cx3cl1 promoter by RFX4_v3 and potentiated RFX4_v3 transactivation on this promoter through X-box 1, suggesting that the protein-protein interaction was functionally relevant. GPS2 bound to both the carboxyl-terminal region (amino acids 575-735) and the middle region (amino acids 250-574) of the RFX4_v3 protein. RFX4_v3 amino acids 1-574 stimulated the Cx3cl1 promoter to a similar extent as the full-length RFX4_v3 protein; however, deletion of the carboxyl-terminal region of RFX4_v3 impaired the co-activating abilities of GPS2. Based on these data, we conclude that GPS2 interacts with RFX4_v3 to modulate transactivation of genes involved in brain morphogenesis, including Cx3Cl1. JF - The Journal of biological chemistry AU - Zhang, Donghui AU - Harry, G Jean AU - Blackshear, Perry J AU - Zeldin, Darryl C AD - Laboratories of Respiratory Biology and Neurobiology, Office of Clinical Research, NIEHS, NIH, Research Triangle Park, NC 27709, USA. Y1 - 2008/03/28/ PY - 2008 DA - 2008 Mar 28 SP - 8580 EP - 8590 VL - 283 IS - 13 SN - 0021-9258, 0021-9258 KW - Chemokine CX3CL1 KW - 0 KW - DNA-Binding Proteins KW - GPS2 protein, human KW - Intracellular Signaling Peptides and Proteins KW - Protein Isoforms KW - Regulatory Factor X Transcription Factors KW - Rfx4 protein, human KW - Rfx4 protein, mouse KW - Transcription Factors KW - Index Medicus KW - Animals KW - COS Cells KW - Cell Nucleus -- metabolism KW - Protein Isoforms -- metabolism KW - Humans KW - Two-Hybrid System Techniques KW - Transcription, Genetic -- genetics KW - Mice KW - Chemokine CX3CL1 -- metabolism KW - Protein Binding KW - Gene Deletion KW - Cercopithecus aethiops KW - Chemokine CX3CL1 -- genetics KW - Gene Expression Regulation KW - Promoter Regions, Genetic -- genetics KW - Protein Isoforms -- genetics KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Alternative Splicing -- genetics KW - Transcription Factors -- metabolism KW - DNA-Binding Proteins -- genetics KW - Transcriptional Activation -- genetics KW - Transcription Factors -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70423093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=G-protein+pathway+suppressor+2+%28GPS2%29+interacts+with+the+regulatory+factor+X4+variant+3+%28RFX4_v3%29+and+functions+as+a+transcriptional+co-activator.&rft.au=Zhang%2C+Donghui%3BHarry%2C+G+Jean%3BBlackshear%2C+Perry+J%3BZeldin%2C+Darryl+C&rft.aulast=Zhang&rft.aufirst=Donghui&rft.date=2008-03-28&rft.volume=283&rft.issue=13&rft.spage=8580&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M708209200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-20 N1 - Date created - 2008-03-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2004 May;24(10):4417-27 [15121860] J Immunol. 2000 Feb 1;164(3):1333-9 [10640747] Nat Neurosci. 2004 Sep;7(9):1003-9 [15332090] Circ Res. 2004 Sep 3;95(5):506-14 [15256482] J Biol Chem. 1994 Mar 11;269(10):7709-18 [8125997] Mol Cell Biol. 1996 Dec;16(12):6698-706 [8943324] J Biol Chem. 1997 Oct 10;272(41):25816-23 [9325311] Mol Cell Biol. 1997 Dec;17(12):7208-19 [9372953] Mol Cell Biol. 1999 Jun;19(6):4311-23 [10330172] J Biol Chem. 2005 May 27;280(21):20503-8 [15790563] Science. 2005 Sep 2;309(5740):1564-6 [16141073] Mol Psychiatry. 2005 Oct;10(10):920-7 [15940297] Cancer Sci. 2005 Nov;96(11):801-9 [16271074] DNA Repair (Amst). 2006 Jan 5;5(1):32-42 [16122992] Neuron. 2006 Jun 15;50(6):813-5 [16772162] Curr Biol. 2000 Jan 27;10(2):86-94 [10662666] Nature. 2000 Feb 24;403(6772):916-21 [10706293] J Virol. 2000 Jul;74(13):5872-9 [10846067] Biochim Biophys Acta. 2000 Sep 7;1493(1-2):249-54 [10978533] J Virol. 2001 Jan;75(1):151-60 [11119584] Annu Rev Immunol. 2001;19:331-73 [11244040] Mol Cell Biol. 2001 Sep;21(17):5913-24 [11486030] Cell. 2001 Oct 5;107(1):55-65 [11595185] J Biol Chem. 2002 Jan 4;277(1):836-42 [11682486] Mol Cell Biol. 2002 Mar;22(6):1804-18 [11865059] Mol Cell. 2002 Mar;9(3):611-23 [11931768] J Neuroimmunol. 2002 Apr;125(1-2):59-65 [11960641] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903 [12477932] J Biol Chem. 2003 Feb 7;278(6):4151-9 [12454018] EMBO J. 2003 Mar 17;22(6):1336-46 [12628926] Glia. 2003 Apr 15;42(2):109-17 [12655595] J Neurosci Res. 2003 Jul 1;73(1):81-8 [12815711] Development. 2003 Oct;130(19):4539-52 [12925582] J Biol Chem. 2004 Mar 12;279(11):10237-42 [14701801] J Neurochem. 2006 Aug;98(3):860-75 [16893423] Expert Rev Neurother. 2006 Sep;6(9):1337-47 [17009921] Curr Opin Neurobiol. 2004 Jun;14(3):318-27 [15194112] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M708209200 ER - TY - JOUR T1 - Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice. AN - 68091791; 18355636 AB - Excitotoxicity involves over activation of brain excitatory glutamate receptors and has been implicated in neurological, neurodegenerative and neuropsychiatric diseases. Metabolism of arachidonic acid (AA) through the phospholipase A(2) (PLA(2))/prostaglandin-endoperoxide synthase (PTGS) pathway is increased after excitotoxic stimulation. However, the individual roles of the PTGS isoforms in this process are not well established. We assessed the role of the PTGS isoforms in the process of excitotoxicity by exposing mice deficient in either PTGS-1 (PTGS-1(-/-)) or PTGS-2 (PTGS-2(-/-)) to the prototypic excitotoxin, kainic acid (KA). Seizure intensity and neuronal damage were significantly elevated in KA-exposed PTGS-2(-/-), but not in PTGS-1(-/-), mice. The increased susceptibility was not associated with an alteration in KA receptor binding activity or mediated through the CB1 endocannabinoid receptor. The frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) was decreased in the CA1 pyramidal neurons of PTGS-2(-/-) mice, suggesting an alteration of GABAergic function. In wild-type mice, six weeks treatment with the PTGS-2 selective inhibitor celecoxib recapitulated the increased susceptibility to KA-induced excitotoxicity observed in PTGS-2(-/-) mice, further supporting the role of PTGS-2 in the excitotoxic process. The increased susceptibility to KA was also associated with decreased brain levels of PGE(2), a biomarker of PTGS-2 activity. Our results suggest that PTGS-2 activity and its specific products may modulate neuronal excitability by affecting GABAergic neurotransmission. Further, inhibition of PTGS-2, but not PTGS-1, may increase the susceptibility to seizures. JF - Brain research bulletin AU - Toscano, Christopher D AU - Ueda, Yumi AU - Tomita, York A AU - Vicini, Stefano AU - Bosetti, Francesca AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA. Y1 - 2008/03/28/ PY - 2008 DA - 2008 Mar 28 SP - 598 EP - 609 VL - 75 IS - 5 SN - 0361-9230, 0361-9230 KW - Membrane Proteins KW - 0 KW - Piperidines KW - Pyrazoles KW - Sulfonamides KW - AM 251 KW - 3I4FA44MAI KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - Ptgs1 protein, mouse KW - Celecoxib KW - JCX84Q7J1L KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Pyrazoles -- administration & dosage KW - Patch-Clamp Techniques -- methods KW - Animals KW - Analysis of Variance KW - Cyclooxygenase 1 -- deficiency KW - Mice KW - Pyrazoles -- blood KW - Autoradiography KW - Membrane Proteins -- deficiency KW - Mice, Knockout KW - Pyrazoles -- pharmacology KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Sulfonamides -- pharmacology KW - Sulfonamides -- blood KW - Neurons -- physiology KW - Chromatography, High Pressure Liquid -- methods KW - Membrane Potentials KW - Piperidines -- administration & dosage KW - Hippocampus -- pathology KW - Statistics, Nonparametric KW - Male KW - Seizures -- chemically induced KW - Cyclooxygenase 2 -- deficiency KW - Seizures -- blood KW - gamma-Aminobutyric Acid -- metabolism KW - Synaptic Transmission -- physiology KW - Seizures -- prevention & control KW - Seizures -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68091791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research+bulletin&rft.atitle=Altered+GABAergic+neurotransmission+is+associated+with+increased+kainate-induced+seizure+in+prostaglandin-endoperoxide+synthase-2+deficient+mice.&rft.au=Toscano%2C+Christopher+D%3BUeda%2C+Yumi%3BTomita%2C+York+A%3BVicini%2C+Stefano%3BBosetti%2C+Francesca&rft.aulast=Toscano&rft.aufirst=Christopher&rft.date=2008-03-28&rft.volume=75&rft.issue=5&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Brain+research+bulletin&rft.issn=03619230&rft_id=info:doi/10.1016%2Fj.brainresbull.2007.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-10 N1 - Date created - 2008-03-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2002 Sep;302(3):846-52 [12183639] J Biol Chem. 2002 Nov 22;277(47):44877-85 [12244105] Int Rev Cytol. 2002;221:93-148 [12455747] J Neurosci. 2003 Mar 15;23(6):2440-52 [12657704] Epilepsy Res. 2003 Aug;55(3):201-10 [12972174] Science. 2003 Oct 3;302(5642):84-8 [14526074] Neuroreport. 2003 Oct 27;14(15):1927-9 [14561922] Neuroscience. 2003;122(2):551-61 [14614919] J Neurochem. 2005 Jun;93(6):1561-7 [15935072] Mol Neurobiol. 2005;31(1-3):3-16 [15953808] Mol Neurobiol. 2005;31(1-3):193-203 [15953821] Brain Res. 2005 Jul 19;1050(1-2):130-7 [15979590] J Neurosci. 2005 Oct 26;25(43):10016-24 [16251450] Epilepsy Behav. 2005 Dec;7 Suppl 3:S3-11 [16278099] Brain Res Cogn Brain Res. 2005 Dec;25(3):826-32 [16263251] J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 18;830(2):245-8 [16297669] Clin Pharmacokinet. 2000 Mar;38(3):225-42 [10749518] Anaesthesia. 2000 May;55(5):442-9 [10792135] Brain Res. 2000 Aug 25;874(2):123-30 [10960596] Annu Rev Biochem. 2000;69:145-82 [10966456] Inflamm Res. 2000 Aug;49(8):367-92 [11028754] J Biol Chem. 2000 Oct 27;275(43):33744-9 [10931854] Eur J Neurosci. 2001 Feb;13(3):569-75 [11168565] Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1294-9 [11158633] J Neurosci. 2001 May 1;21(9):3009-16 [11312285] Neuropharmacology. 2001 Nov;41(6):730-6 [11640927] Behav Pharmacol. 2003 Dec;14(8):573-82 [14665974] Curr Pharm Des. 2004;10(6):659-67 [14965328] Mol Cell Neurosci. 2004 Mar;25(3):469-79 [15033175] Neuroscience. 2004;125(2):317-27 [15062975] Cancer Res. 2004 May 15;64(10):3668-78 [15150127] Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8512-3 [15173576] Nat Neurosci. 2004 Jul;7(7):697-8 [15184902] Br J Pharmacol. 2004 Aug;142(8):1354-60 [15277315] J Neurophysiol. 2004 Sep;92(3):1718-27 [15102896] Brain Res. 2004 Oct 22;1024(1-2):59-76 [15451367] J Neurosci. 2004 Oct 13;24(41):8986-93 [15483117] Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94 [4110397] Prostaglandins. 1978 Jun;15(6):925-42 [693918] Life Sci. 1978 Dec 25;23(26):2609-16 [368484] Eur J Pharmacol. 1981 Jan 16;69(2):199-203 [7202518] J Biol Chem. 2006 May 26;281(21):14663-9 [16569634] J Physiol. 2006 May 1;572(Pt 3):735-45 [16484297] J Neurochem. 2006 Aug;98(3):801-11 [16787416] Neurosci Res. 2006 Sep;56(1):103-10 [16837093] Eur J Neurosci. 2006 Oct;24(8):2191-202 [17074044] Genome Biol. 2007;8(1):R14 [17266762] J Gerontol A Biol Sci Med Sci. 1999 Oct;54(10):B407-17 [10568523] Eur J Pharmacol. 2000 Mar 3;390(3):295-8 [10708736] Brain Res. 1984 Jul 9;305(2):393-5 [6430471] Neurosci Lett. 1989 Aug 14;103(1):56-63 [2476693] Neuron. 1993 Aug;11(2):371-86 [8352945] Food Chem Toxicol. 1993 Oct;31(10):701-6 [8225127] Brain Res. 1994 May 23;646(2):201-6 [8069664] Cell. 1995 Nov 3;83(3):473-82 [8521477] Cell. 1995 Nov 3;83(3):483-92 [8521478] Eur J Pharmacol. 1996 Jul 4;307(3):331-8 [8836622] Clin Neurosci. 1995-1996;3(6):348-59 [9021256] Neuroscience. 1997 Apr;77(3):649-59 [9070742] Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4103-8 [9108112] J Biol Chem. 1997 Aug 22;272(34):21181-6 [9261124] Prostaglandins. 1997 Sep;54(3):601-24 [9373877] Epilepsy Res. 1998 Mar;30(1):63-8 [9551845] Brain Res. 1998 Apr 27;791(1-2):325-9 [9593973] Lancet. 1999 Jan 23;353(9149):307-14 [9929039] Am J Pathol. 1999 Sep;155(3):995-1004 [10487857] Brain Res. 1999 Oct 2;843(1-2):118-29 [10528118] J Neurochem. 2004 Dec;91(6):1389-97 [15584915] Anesthesiology. 2005 Feb;102(2):409-15 [15681959] Am J Alzheimers Dis Other Demen. 2005 Mar-Apr;20(2):77-85 [15844753] Neuron. 2002 Mar 14;33(6):849-60 [11906693] Arch Gen Psychiatry. 2002 Jul;59(7):592-6 [12090811] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainresbull.2007.10.004 ER - TY - JOUR T1 - Structural Characterization of the Yersinia pestis Type III Secretion System Needle Protein YscF in Complex with Its Heterodimeric Chaperone YscE/YscG AN - 20774618; 8245440 AB - The plague-causing bacterium Yersinia pestis utilizes a type III secretion system to deliver effector proteins into mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. Effector proteins are injected through a hollow needle structure composed of the protein YscF. YscG and YscE act as ''chaperones'' to prevent premature polymerization of YscF in the cytosol of the bacterium prior to assembly of the needle. Here, we report the crystal structure of the YscEFG protein complex at 1.8 A resolution. Overall, the structure is similar to that of the analogous PscEFG complex from the Pseudomonas aeruginosa type III secretion system, but there are noteworthy differences. The structure confirms that, like PscG, YscG is a member of the tetratricopeptide repeat family of proteins. YscG binds tightly to the C-terminal half of YscF, implying that it is this region of YscF that controls its polymerization into the needle structure. YscE interacts with the N-terminal tetratricopeptide repeat motif of YscG but makes very little direct contact with YscF. Its function may be to stabilize the structure of YscG and/or to participate in recruiting the complex to the secretion apparatus. No electron density could be observed for the 49 N-terminal residues of YscF. This and additional evidence suggest that the N-terminus of YscF is disordered in the complex with YscE and YscG. As expected, conserved residues in the C-terminal half of YscF mediate important intra- and intermolecular interactions in the complex. Moreover, the phenotypes of some previously characterized mutations in the C-terminal half of YscF can be rationalized in terms of the structure of the heterotrimeric YscEFG complex. JF - Journal of Molecular Biology AU - Sun, P AU - Tropea, JE AU - Austin, B P AU - Cherry, S AU - Waugh, D S AD - Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD, USA, waughd@ncifcrf.gov Y1 - 2008/03/28/ PY - 2008 DA - 2008 Mar 28 SP - 819 EP - 830 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 377 IS - 3 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology KW - Polymerization KW - Secretion KW - Yersinia pestis KW - Inflammation KW - N-Terminus KW - Mammalian cells KW - Cytosol KW - Crystal structure KW - Chaperones KW - Pseudomonas aeruginosa KW - Phagocytosis KW - Mutation KW - Signal transduction KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20774618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Structural+Characterization+of+the+Yersinia+pestis+Type+III+Secretion+System+Needle+Protein+YscF+in+Complex+with+Its+Heterodimeric+Chaperone+YscE%2FYscG&rft.au=Sun%2C+P%3BTropea%2C+JE%3BAustin%2C+B+P%3BCherry%2C+S%3BWaugh%2C+D+S&rft.aulast=Sun&rft.aufirst=P&rft.date=2008-03-28&rft.volume=377&rft.issue=3&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2007.12.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Polymerization; Mammalian cells; Secretion; Crystal structure; Cytosol; Chaperones; Phagocytosis; Mutation; N-Terminus; Signal transduction; Inflammation; Yersinia pestis; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1016/j.jmb.2007.12.067 ER - TY - JOUR T1 - Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges. AN - 70446534; 18313226 AB - 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) stimulates the transporter-mediated release of monoamines, including 5-HT. High-dose exposure to MDMA causes persistent 5-HT deficits (e.g. depletion of brain 5-HT) in animals, yet the functional and clinical relevance of such deficits are poorly defined. Here we examine functional consequences of MDMA-induced 5-HT depletions in rats. Male rats received binges of three i.p. injections of MDMA or saline, one injection every 2 h; MDMA was given at a threshold pharmacological dose (1.5 mg/kgx3, low dose) or at a fivefold higher amount (7.5 mg/kgx3, high dose). One week later, jugular catheters and intracerebral guide cannulae were implanted. Two weeks after binges, rats received acute i.v. challenge injections of 1 and 3 mg/kg MDMA. Neuroendocrine effects evoked by i.v. MDMA (prolactin and corticosterone secretion) were assessed via serial blood sampling, while neurochemical effects (5-HT and dopamine release) were assessed via microdialysis in brain. MDMA binges elevated core temperatures only in the high-dose group, with these same rats exhibiting approximately 50% loss of forebrain 5-HT 2 weeks later. Prior exposure to MDMA did not alter baseline plasma hormones or dialysate monoamines, and effects of i.v. MDMA were similar in saline and low-dose groups. By contrast, rats pretreated with high-dose MDMA displayed significant reductions in evoked hormone secretion and 5-HT release when challenged with i.v. MDMA. As tolerance developed only in rats exposed to high-dose binges, hyperthermia and 5-HT depletion are implicated in this phenomenon. Our results suggest that MDMA tolerance in humans may reflect 5-HT deficits which could contribute to further dose escalation. JF - Neuroscience AU - Baumann, M H AU - Clark, R D AU - Franken, F H AU - Rutter, J J AU - Rothman, R B AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 333 Cassell Drive, Suite 4500, Baltimore, MD 21224, USA. mbaumann@mail.nih.gov Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 SP - 773 EP - 784 VL - 152 IS - 3 SN - 0306-4522, 0306-4522 KW - Serotonin Agents KW - 0 KW - Serotonin KW - 333DO1RDJY KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Dopamine -- secretion KW - Animals KW - Hypothalamo-Hypophyseal System -- drug effects KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Synaptic Transmission -- drug effects KW - Extracellular Fluid -- drug effects KW - Hypothalamo-Hypophyseal System -- metabolism KW - Dopamine -- metabolism KW - Fever -- physiopathology KW - Infusions, Parenteral KW - Rats KW - Microdialysis KW - Fever -- chemically induced KW - Rats, Sprague-Dawley KW - Extracellular Fluid -- metabolism KW - Fever -- metabolism KW - Male KW - Hypothalamo-Hypophyseal System -- secretion KW - Brain -- physiopathology KW - Drug Tolerance KW - Serotonin -- secretion KW - Brain -- drug effects KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Serotonin Agents -- toxicity KW - Brain -- metabolism KW - Down-Regulation -- drug effects KW - Serotonin -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70446534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Tolerance+to+3%2C4-methylenedioxymethamphetamine+in+rats+exposed+to+single+high-dose+binges.&rft.au=Baumann%2C+M+H%3BClark%2C+R+D%3BFranken%2C+F+H%3BRutter%2C+J+J%3BRothman%2C+R+B&rft.aulast=Baumann&rft.aufirst=M&rft.date=2008-03-27&rft.volume=152&rft.issue=3&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2008.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-21 N1 - Date created - 2008-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacol Biochem Behav. 2003 Mar;74(4):987-95 [12667914] Pharmacol Rev. 2003 Sep;55(3):463-508 [12869661] Hum Psychopharmacol. 2003 Oct;18(7):507-17 [14533132] Psychopharmacology (Berl). 2007 Jan;189(4):407-24 [16541247] Psychopharmacology (Berl). 2007 Jan;189(4):471-82 [16555062] Neuroscience. 2007 Aug 10;148(1):212-20 [17629409] Trends Pharmacol Sci. 2004 Oct;25(10):505-8 [15380932] J Pharmacol Exp Ther. 1987 Apr;241(1):338-45 [2883295] J Pharmacol Exp Ther. 1987 Sep;242(3):911-6 [2443644] Neuropharmacology. 1987 Dec;26(12):1677-83 [2893986] J Pharmacol Exp Ther. 1988 Jun;245(3):873-9 [2898523] J Pharmacol Exp Ther. 1988 Nov;247(2):547-55 [2903234] Pharmacol Biochem Behav. 1988 Dec;31(4):817-24 [2908067] Pharmacol Biochem Behav. 1989 Apr;32(4):835-40 [2572003] Neurotoxicology. 1989 Fall;10(3):529-42 [2576304] Pharmacol Biochem Behav. 1990 Mar;35(3):637-42 [1971112] Pharmacol Biochem Behav. 1991 Mar;38(3):539-44 [1676847] Psychopharmacology (Berl). 1991;104(3):293-301 [1924637] J Pharmacol Exp Ther. 1992 Oct;263(1):318-26 [1357158] Pharmacol Biochem Behav. 1992 Nov;43(3):759-63 [1360162] Front Neuroendocrinol. 1994 Jun;15(2):85-156 [7813744] Psychopharmacology (Berl). 1994 Dec;116(4):508-14 [7535469] Synapse. 1995 Jun;20(2):99-105 [7570349] J Pharmacol Exp Ther. 1995 Oct;275(1):325-33 [7562567] J Neurochem. 1996 Jan;66(1):243-9 [8522960] Neurotoxicol Teratol. 1995 Sep-Oct;17(5):531-43 [8551999] Physiol Behav. 1995 Nov;58(5):877-82 [8577883] J Pharmacol Exp Ther. 1996 Oct;279(1):277-83 [8859004] Prog Neurobiol. 1996 Aug;49(5):455-79 [8895996] Neurosci Biobehav Rev. 1997 Jan;21(1):67-78 [8994210] Psychopharmacology (Berl). 1997 Jun;131(4):411-9 [9226745] Neuropsychopharmacology. 1998 Jun;18(6):469-79 [9571655] Pharmacol Biochem Behav. 1998 Apr;59(4):1003-9 [9586861] Neuropharmacology. 1998 Jul;37(7):919-26 [9776387] J Neurosci. 1998 Nov 1;18(21):9069-77 [9787010] Drug Metab Dispos. 1998 Dec;26(12):1202-12 [9860929] Int Clin Psychopharmacol. 1998 Jan;13(1):1-9 [9988361] Psychopharmacology (Berl). 1999 May;144(1):67-76 [10379626] Synapse. 1999 Jul;33(1):16-25 [10380847] J Pharmacol Exp Ther. 1999 Jul;290(1):136-45 [10381769] J Pharmacol Exp Ther. 1999 Sep;290(3):965-73 [10454466] J Psychopharmacol. 2005 Jan;19(1):71-83 [15671132] Neuropsychopharmacology. 2005 Mar;30(3):550-60 [15496938] J Pharmacol Exp Ther. 2005 Sep;314(3):1002-12 [15937150] Neuroscience. 2005;136(1):43-53 [16203101] Drug Alcohol Depend. 2006 Jan 4;81(1):27-36 [15975736] Psychopharmacology (Berl). 2006 Jan;184(2):239-46 [16362399] Psychopharmacology (Berl). 1999 Nov;147(1):66-72 [10591870] Brain Res Brain Res Rev. 1999 Dec;31(1):6-41 [10611493] Biol Psychiatry. 2000 Jan 15;47(2):127-36 [10664829] Behav Pharmacol. 1999 Mar;10(2):195-204 [10780832] Neuropsychobiology. 2000;42(1):5-10 [10867550] J Clin Psychopharmacol. 2000 Aug;20(4):455-66 [10917407] Psychopharmacology (Berl). 2001 Jan 1;153(2):196-202 [11205419] Brain Res. 2003 Dec 24;994(2):203-15 [14642646] Psychopharmacology (Berl). 2004 May;173(3-4):364-75 [15071716] Neuropsychopharmacology. 2004 Jul;29(7):1270-81 [15039771] J Psychopharmacol. 2006 Mar;20(2):194-210 [16510478] J Psychopharmacol. 2006 May;20(3):456-63 [16574720] J Pharmacol Exp Ther. 2006 May;317(2):838-49 [16434566] J Pharmacol Exp Ther. 2001 Jun;297(3):846-52 [11356903] Br J Pharmacol. 2002 Jan;135(1):170-80 [11786492] Neuroscience. 2002;110(1):41-8 [11882371] Ann N Y Acad Sci. 2002 Jun;965:410-20 [12105116] Pharmacol Ther. 2002 Jul;95(1):73-88 [12163129] Psychopharmacology (Berl). 2002 Aug;162(4):396-405 [12172693] Addiction. 2002 Dec;97(12):1531-6 [12472637] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2008.01.007 ER - TY - JOUR T1 - Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies. AN - 70412294; 18314945 AB - The carboxylic acid group of the anti-inflammatory (AI) drugs aspirin and indomethacin was covalently linked to the 1-(2-carboxypyrrolidin-1-yl)diazen-1-ium-1,2-diolate ion via a one-carbon methylene spacer to obtain two new hybrid prodrugs. The aspirin prodrug ( 23) was a 2.2-fold more potent AI agent than aspirin, whereas the indomethacin prodrug ( 26) was about 1.6-fold less potent than indomethacin. Prodrugs 23 and 26 slowly released nitric oxide (NO) upon dissolution in phosphate buffer at pH 7.4 (1.1 mol of NO/mol of compound after 43 h), but the rate and the extent of NO release were higher (1.9 mol of NO/mol of compound in 3 min or less) when the compounds were incubated in the presence of porcine liver esterase. In vivo ulcer index (UI) studies showed that the aspirin prodrug 23 (UI = 0.7) and indomethacin prodrug 26 (UI = 0) were substantially less ulcerogenic than the parent drugs aspirin (UI = 51) and indomethacin (UI = 64). JF - Journal of medicinal chemistry AU - Velázquez, Carlos A AU - Chen, Qiao-Hong AU - Citro, Michael L AU - Keefer, Larry K AU - Knaus, Edward E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis and Basic Research Program, SAIC-Frederick Inc., National Cancer Institute at Frederick, MD 21702, USA. Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 SP - 1954 EP - 1961 VL - 51 IS - 6 SN - 0022-2623, 0022-2623 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Azo Compounds KW - Nitric Oxide Donors KW - Prodrugs KW - Pyrrolidines KW - Nitric Oxide KW - 31C4KY9ESH KW - Carrageenan KW - 9000-07-1 KW - Aspirin KW - R16CO5Y76E KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Rats KW - Molecular Structure KW - Administration, Oral KW - Edema -- chemically induced KW - Animals KW - Edema -- drug therapy KW - Drug Design KW - Stomach Ulcer -- chemically induced KW - Pyrrolidines -- chemical synthesis KW - Azo Compounds -- chemical synthesis KW - Prodrugs -- chemistry KW - Anti-Inflammatory Agents, Non-Steroidal -- chemical synthesis KW - Aspirin -- chemical synthesis KW - Indomethacin -- chemical synthesis KW - Prodrugs -- chemical synthesis KW - Indomethacin -- pharmacology KW - Nitric Oxide Donors -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- chemistry KW - Indomethacin -- chemistry KW - Aspirin -- chemistry KW - Azo Compounds -- chemistry KW - Pyrrolidines -- chemistry KW - Prodrugs -- pharmacology KW - Pyrrolidines -- pharmacology KW - Azo Compounds -- pharmacology KW - Nitric Oxide -- chemistry KW - Nitric Oxide Donors -- chemical synthesis KW - Aspirin -- pharmacology KW - Nitric Oxide Donors -- chemistry KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70412294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Second-generation+aspirin+and+indomethacin+prodrugs+possessing+an+O%282%29-%28acetoxymethyl%29-1-%282-carboxypyrrolidin-1-yl%29diazenium-1%2C2-diolate+nitric+oxide+donor+moiety%3A+design%2C+synthesis%2C+biological+evaluation%2C+and+nitric+oxide+release+studies.&rft.au=Vel%C3%A1zquez%2C+Carlos+A%3BChen%2C+Qiao-Hong%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BKnaus%2C+Edward+E&rft.aulast=Vel%C3%A1zquez&rft.aufirst=Carlos&rft.date=2008-03-27&rft.volume=51&rft.issue=6&rft.spage=1954&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm701450q LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-11 N1 - Date created - 2008-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm701450q ER - TY - CPAPER T1 - Criteria for Advancement of Novel Vaccine Candidates T2 - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AN - 40809496; 4802354 JF - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AU - Nabel, Gary J Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.atitle=Criteria+for+Advancement+of+Novel+Vaccine+Candidates&rft.au=Nabel%2C+Gary+J&rft.aulast=Nabel&rft.aufirst=Gary&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Influence of HLA Class I and KIR on HIV-1 Disease T2 - 2008 Keystone Symposia on HIV Pathogenesis (X8) AN - 40809260; 4802310 JF - 2008 Keystone Symposia on HIV Pathogenesis (X8) AU - Carrington, Mary Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Histocompatibility antigen HLA KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.atitle=The+Influence+of+HLA+Class+I+and+KIR+on+HIV-1+Disease&rft.au=Carrington%2C+Mary&rft.aulast=Carrington&rft.aufirst=Mary&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 3&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Events in the HIV-Infected Gut T2 - 2008 Keystone Symposia on HIV Pathogenesis (X8) AN - 40808953; 4802306 JF - 2008 Keystone Symposia on HIV Pathogenesis (X8) AU - Douek, Daniel C Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Digestive tract KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40808953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.atitle=Immune+Events+in+the+HIV-Infected+Gut&rft.au=Douek%2C+Daniel+C&rft.aulast=Douek&rft.aufirst=Daniel&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 3&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Frequency and Phenotype of HIV gp120-Specific B Cells from Patients with Broadly Cross-Neutralizing Antibodies T2 - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AN - 40807908; 4802368 JF - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AU - Doria-Rose, Nicole A Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Human immunodeficiency virus KW - Lymphocytes B KW - Antibodies KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.atitle=Frequency+and+Phenotype+of+HIV+gp120-Specific+B+Cells+from+Patients+with+Broadly+Cross-Neutralizing+Antibodies&rft.au=Doria-Rose%2C+Nicole+A&rft.aulast=Doria-Rose&rft.aufirst=Nicole&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does T-Cell Function during Acute/Early HIV Predict Outcome? T2 - 2008 Keystone Symposia on HIV Pathogenesis (X8) AN - 40807713; 4802320 JF - 2008 Keystone Symposia on HIV Pathogenesis (X8) AU - Chattopadhyay, Pratip K Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Human immunodeficiency virus KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.atitle=Does+T-Cell+Function+during+Acute%2FEarly+HIV+Predict+Outcome%3F&rft.au=Chattopadhyay%2C+Pratip+K&rft.aulast=Chattopadhyay&rft.aufirst=Pratip&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 3&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Th17 Cells are Preferentially Depleted from GI Tract, but Not BAL or Blood, of HIV-Infected Individuals T2 - 2008 Keystone Symposia on HIV Pathogenesis (X8) AN - 40807678; 4802319 JF - 2008 Keystone Symposia on HIV Pathogenesis (X8) AU - Brenchley, Jason M Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Blood KW - Gastrointestinal tract KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.atitle=Th17+Cells+are+Preferentially+Depleted+from+GI+Tract%2C+but+Not+BAL+or+Blood%2C+of+HIV-Infected+Individuals&rft.au=Brenchley%2C+Jason+M&rft.aulast=Brenchley&rft.aufirst=Jason&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 3&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD4-Binding-Site Antibodies: Prospects, Complications, and Crystallographic Analyses T2 - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AN - 40807521; 4802366 JF - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AU - Kwong, Peter D Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Antibodies KW - CD4 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.atitle=CD4-Binding-Site+Antibodies%3A+Prospects%2C+Complications%2C+and+Crystallographic+Analyses&rft.au=Kwong%2C+Peter+D&rft.aulast=Kwong&rft.aufirst=Peter&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elicitation of Co-Receptor Site Directed Antibodies against HIV-1 is caused by Primary Receptor Binding to the Viral Envelope Glycoproteins T2 - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AN - 40807439; 4802351 JF - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AU - Forsell, Mattias Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Glycoproteins KW - Envelopes KW - Antibodies KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.atitle=Elicitation+of+Co-Receptor+Site+Directed+Antibodies+against+HIV-1+is+caused+by+Primary+Receptor+Binding+to+the+Viral+Envelope+Glycoproteins&rft.au=Forsell%2C+Mattias&rft.aulast=Forsell&rft.aufirst=Mattias&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-Specific B Cells are Enriched in a Dysfunctional Tissue-like Memory B-Cell Compartment in HIV-Infected Viremic Individuals T2 - 2008 Keystone Symposia on HIV Pathogenesis (X8) AN - 40806987; 4802317 JF - 2008 Keystone Symposia on HIV Pathogenesis (X8) AU - Ho, Jason Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Lymphocytes B KW - Memory cells KW - Immunological memory KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40806987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.atitle=HIV-Specific+B+Cells+are+Enriched+in+a+Dysfunctional+Tissue-like+Memory+B-Cell+Compartment+in+HIV-Infected+Viremic+Individuals&rft.au=Ho%2C+Jason&rft.aulast=Ho&rft.aufirst=Jason&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Pathogenesis+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 3&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunomodulation of Human Dendritic Cells by MVA and Ad5 Vaccine Vectors T2 - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AN - 40804302; 4802364 JF - 2008 Keystone Symposia on HIV Vaccines: Progress and Prospects (X7) AU - Santos, Kathlyn Y1 - 2008/03/27/ PY - 2008 DA - 2008 Mar 27 KW - Vaccines KW - Dendritic cells KW - Immunomodulation KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40804302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.atitle=Immunomodulation+of+Human+Dendritic+Cells+by+MVA+and+Ad5+Vaccine+Vectors&rft.au=Santos%2C+Kathlyn&rft.aulast=Santos&rft.aufirst=Kathlyn&rft.date=2008-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+HIV+Vaccines%3A+Progress+and+Prospects+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. AN - 70431705; 18367605 AB - Parkinson's disease (PD), a progressive neurodegenerative disease characterized by bradykinesia, rigidity, and resting tremor, is the most common neurodegenerative movement disorder. Although the majority of PD cases are sporadic, some are inherited, including those caused by leucine-rich repeat kinase 2 (LRRK2) mutations. The substitution of serine for glycine at position 2019 (G2019S) in the kinase domain of LRRK2 represents the most prevalent genetic mutation in both familial and apparently sporadic cases of PD. Because mutations in LRRK2 are likely associated with a toxic gain of function, destabilization of LRRK2 may be a novel way to limit its detrimental effects. Here we show that LRRK2 forms a complex with heat shock protein 90 (Hsp90) in vivo and that inhibition of Hsp90 disrupts the association of Hsp90 with LRRK2 and leads to proteasomal degradation of LRRK2. Hsp90 inhibitors may therefore limit the mutant LRRK2-elicited toxicity to neurons. As a proof of principle, we show that Hsp90 inhibitors rescue the axon growth retardation caused by overexpression of the LRRK2 G2019S mutation in neurons. Therefore, inhibition of LRRK2 kinase activity can be achieved by blocking Hsp90-mediated chaperone activity and Hsp90 inhibitors may serve as potential anti-PD drugs. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Wang, Lizhen AU - Xie, Chengsong AU - Greggio, Elisa AU - Parisiadou, Loukia AU - Shim, Hoon AU - Sun, Lixin AU - Chandran, Jayanth AU - Lin, Xian AU - Lai, Chen AU - Yang, Wan-Jou AU - Moore, Darren J AU - Dawson, Ted M AU - Dawson, Valina L AU - Chiosis, Gabriela AU - Cookson, Mark R AU - Cai, Huaibin AD - Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland 20892, USA. Y1 - 2008/03/26/ PY - 2008 DA - 2008 Mar 26 SP - 3384 EP - 3391 VL - 28 IS - 13 KW - Benzodioxoles KW - 0 KW - Cdc37 protein, mouse KW - Cell Cycle Proteins KW - Enzyme Inhibitors KW - HSP90 Heat-Shock Proteins KW - Molecular Chaperones KW - Purines KW - 9H-purine-9-propanamine, 6-amino-8-((6-iodo-1,3-benzodioxol-5-yl)thio)-N-(1-methylethyl)- KW - 06IVK87M04 KW - Serine KW - 452VLY9402 KW - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 KW - EC 2.7.11.1 KW - Lrrk2 protein, mouse KW - Protein-Serine-Threonine Kinases KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Brain -- cytology KW - Molecular Chaperones -- metabolism KW - Humans KW - Mice, Transgenic KW - Protein Binding -- physiology KW - Proteasome Endopeptidase Complex -- metabolism KW - Mutation -- physiology KW - Immunoprecipitation -- methods KW - Neurons -- metabolism KW - Mice KW - Cell Cycle Proteins -- metabolism KW - Serine -- genetics KW - Transfection -- methods KW - Animals, Newborn KW - Glycine -- genetics KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - Mass Spectrometry -- methods KW - Purines -- pharmacology KW - Silver Staining -- methods KW - Benzodioxoles -- pharmacology KW - Protein-Serine-Threonine Kinases -- metabolism KW - HSP90 Heat-Shock Proteins -- metabolism KW - Protein-Serine-Threonine Kinases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70431705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=The+chaperone+activity+of+heat+shock+protein+90+is+critical+for+maintaining+the+stability+of+leucine-rich+repeat+kinase+2.&rft.au=Wang%2C+Lizhen%3BXie%2C+Chengsong%3BGreggio%2C+Elisa%3BParisiadou%2C+Loukia%3BShim%2C+Hoon%3BSun%2C+Lixin%3BChandran%2C+Jayanth%3BLin%2C+Xian%3BLai%2C+Chen%3BYang%2C+Wan-Jou%3BMoore%2C+Darren+J%3BDawson%2C+Ted+M%3BDawson%2C+Valina+L%3BChiosis%2C+Gabriela%3BCookson%2C+Mark+R%3BCai%2C+Huaibin&rft.aulast=Wang&rft.aufirst=Lizhen&rft.date=2008-03-26&rft.volume=28&rft.issue=13&rft.spage=3384&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.0185-08.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-28 N1 - Date created - 2008-03-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1999 Nov 17;91(22):1940-9 [10564678] Curr Top Med Chem. 2006;6(11):1091-107 [16842148] Biochim Biophys Acta. 2004 Mar 11;1697(1-2):233-42 [15023364] J Biol Chem. 2004 Jun 11;279(24):25497-502 [15044495] Curr Top Med Chem. 2006;6(11):1205-14 [16842157] Neurobiol Dis. 2006 Aug;23(2):329-41 [16750377] J Mol Med (Berl). 2006 Aug;84(8):635-46 [16741751] Eur J Hum Genet. 2006 Oct;14(10):1061-2 [16835587] Nat Neurosci. 2006 Oct;9(10):1231-3 [16980962] Ann Neurol. 2006 Oct;60(4):389-98 [17068789] J Neurosci. 2006 Nov 8;26(45):11798-806 [17093100] Neuron. 2006 Nov 22;52(4):587-93 [17114044] Ann Neurol. 2006 Nov;60(5):557-69 [17120249] Hum Mol Genet. 2007 Jan 15;16(2):223-32 [17200152] J Clin Invest. 2007 Mar;117(3):648-58 [17304350] J Clin Invest. 2007 Mar;117(3):590-2 [17332887] Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6 [17517623] Biochem J. 2007 Jul 15;405(2):307-17 [17447891] Nat Chem Biol. 2007 Aug;3(8):498-507 [17603540] Hum Mol Genet. 2007 Sep 1;16(17):2031-9 [17584768] J Neurochem. 2007 Oct;103(1):238-47 [17623048] Exp Cell Res. 2007 Oct 1;313(16):3658-70 [17706965] Parkinsonism Relat Disord. 2007 Oct;13(7):382-5 [17400507] Expert Rev Proteomics. 2007 Dec;4(6):783-92 [18067416] Neurobiol Aging. 2008 Mar;29(3):357-67 [17157415] J Neurochem. 2008 May;105(3):1048-56 [18182054] Drug Discov Today. 2004 Oct 15;9(20):881-8 [15475321] Science. 1996 Dec 6;274(5293):1678-83 [8939850] Neuron. 2004 Nov 18;44(4):595-600 [15541308] Neuron. 2004 Nov 18;44(4):601-7 [15541309] J Biol Chem. 2005 Jan 28;280(4):2873-8 [15556931] Annu Rev Neurosci. 2005;28:57-87 [16022590] J Mol Biol. 2005 Sep 2;351(5):1081-100 [16051265] J Neurosci. 2005 Aug 17;25(33):7567-74 [16107644] Neurology. 2005 Sep 13;65(5):738-40 [16157908] J Med Genet. 2005 Nov;42(11):e65 [16272257] Hum Mol Genet. 2005 Dec 1;14(23):3549-56 [16269443] PLoS Med. 2005 Dec;2(12):e355 [16279840] Hum Mol Genet. 2006 Jan 15;15(2):223-32 [16321986] Trends Neurosci. 2006 May;29(5):286-93 [16616379] Annu Rev Biochem. 2006;75:271-94 [16756493] Nat Med. 2002 Nov;8(11):1185-6 [12411925] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.0185-08.2008 ER - TY - JOUR T1 - p16(INK4a) translation suppressed by miR-24. AN - 70427512; 18365017 AB - Expression of the tumor suppressor p16(INK4a) increases during aging and replicative senescence. Here, we report that the microRNA miR-24 suppresses p16 expression in human diploid fibroblasts and cervical carcinoma cells. Increased p16 expression with replicative senescence was associated with decreased levels of miR-24, a microRNA that was predicted to associate with the p16 mRNA coding and 3'-untranslated regions. Ectopic miR-24 overexpression reduced p16 protein but not p16 mRNA levels. Conversely, introduction of antisense (AS)-miR-24 blocked miR-24 expression and markedly enhanced p16 protein levels, p16 translation, and the production of EGFP-p16 reporter bearing the miR-24 target recognition sites. Together, our results suggest that miR-24 represses the initiation and elongation phases of p16 translation. JF - PloS one AU - Lal, Ashish AU - Kim, Hyeon Ho AU - Abdelmohsen, Kotb AU - Kuwano, Yuki AU - Pullmann, Rudolf AU - Srikantan, Subramanya AU - Subrahmanyam, Ramesh AU - Martindale, Jennifer L AU - Yang, Xiaoling AU - Ahmed, Fariyal AU - Navarro, Francisco AU - Dykxhoorn, Derek AU - Lieberman, Judy AU - Gorospe, Myriam AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging-IRP, National Institutes of Health, Baltimore, Maryland, United States of America. alal@cbrinstitute.org Y1 - 2008/03/26/ PY - 2008 DA - 2008 Mar 26 SP - 1 VL - 3 IS - 3 KW - Cyclin-Dependent Kinase Inhibitor p16 KW - 0 KW - DNA Primers KW - MicroRNAs KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Base Sequence KW - HeLa Cells KW - Humans KW - Protein Biosynthesis KW - Cyclin-Dependent Kinase Inhibitor p16 -- genetics KW - MicroRNAs -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70427512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=p16%28INK4a%29+translation+suppressed+by+miR-24.&rft.au=Lal%2C+Ashish%3BKim%2C+Hyeon+Ho%3BAbdelmohsen%2C+Kotb%3BKuwano%2C+Yuki%3BPullmann%2C+Rudolf%3BSrikantan%2C+Subramanya%3BSubrahmanyam%2C+Ramesh%3BMartindale%2C+Jennifer+L%3BYang%2C+Xiaoling%3BAhmed%2C+Fariyal%3BNavarro%2C+Francisco%3BDykxhoorn%2C+Derek%3BLieberman%2C+Judy%3BGorospe%2C+Myriam&rft.aulast=Lal&rft.aufirst=Ashish&rft.date=2008-03-26&rft.volume=3&rft.issue=3&rft.spage=e1864&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0001864 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2008-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 1999 Oct 15;13(20):2678-90 [10541554] Nat Rev Genet. 2008 Feb;9(2):102-14 [18197166] EMBO J. 2000 Jun 15;19(12):2969-79 [10856241] Nature. 2001 Feb 22;409(6823):1067-70 [11234019] Cell Biochem Biophys. 2000;33(2):189-97 [11325039] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7812-6 [11427735] Dev Biol. 2002 Mar 15;243(2):215-25 [11884032] J Cell Physiol. 2002 Oct;193(1):19-25 [12209876] Science. 2002 Sep 20;297(5589):2056-60 [12154197] Genes Dev. 2002 Nov 1;16(21):2733-42 [12414724] Science. 2003 May 2;300(5620):805-8 [12730603] Curr Opin Cell Biol. 2003 Jun;15(3):326-31 [12787775] Science. 2004 Apr 23;304(5670):594-6 [15105502] J Biol Chem. 2004 Oct 1;279(40):41414-21 [15254040] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13742-7 [8943005] Oncogene. 1997 Jul 10;15(2):203-11 [9244355] Eur J Cancer. 1997 Apr;33(5):703-9 [9282108] Exp Cell Res. 1997 Nov 25;237(1):7-13 [9417860] Curr Biol. 1998 Mar 12;8(6):351-4 [9512419] Lab Invest. 1999 Sep;79(9):1137-43 [10496532] J Clin Invest. 2004 Nov;114(9):1299-307 [15520862] Exp Cell Res. 1965 Mar;37:614-36 [14315085] EMBO Rep. 2005 Feb;6(2):158-64 [15678155] EMBO J. 2005 May 18;24(10):1852-62 [15861128] Mutat Res. 2005 Aug 25;576(1-2):22-38 [15878778] Science. 2005 Sep 2;309(5740):1514-8 [16141059] Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):16961-6 [16287976] Mol Cell. 2006 Feb 17;21(4):533-42 [16483934] Genes Dev. 2006 Mar 1;20(5):515-24 [16510870] J Cell Biol. 2006 Mar 13;172(6):803-8 [16520386] Nature. 2006 Mar 30;440(7084):702-6 [16572177] Cell. 2006 Sep 22;126(6):1203-17 [16990141] Cell. 2006 Oct 20;127(2):265-75 [17055429] Nat Rev Mol Cell Biol. 2007 Jan;8(1):9-22 [17183357] RNA Biol. 2006 Apr;3(2):57-9 [17114943] Trends Cell Biol. 2007 Mar;17(3):118-26 [17197185] Nature. 2007 Jun 14;447(7146):875-8 [17507927] Nature. 2007 Jun 14;447(7146):823-8 [17507929] RNA. 2007 Aug;13(8):1198-204 [17592038] Dev Biol. 1999 Dec 15;216(2):671-80 [10642801] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0001864 ER - TY - CPAPER T1 - The AP4 Complex Mediates Sorting of the Amyloid Precursor Protein at the trans-Golgi Network. T2 - 2008 Keystone Symposia on Alzheimer's Disease (C7) AN - 40808503; 4802275 JF - 2008 Keystone Symposia on Alzheimer's Disease (C7) AU - Burgos, Patricia V Y1 - 2008/03/24/ PY - 2008 DA - 2008 Mar 24 KW - Alzheimer's disease KW - Amyloid precursor protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40808503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Alzheimer%27s+Disease+%28C7%29&rft.atitle=The+AP4+Complex+Mediates+Sorting+of+the+Amyloid+Precursor+Protein+at+the+trans-Golgi+Network.&rft.au=Burgos%2C+Patricia+V&rft.aulast=Burgos&rft.aufirst=Patricia&rft.date=2008-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Alzheimer%27s+Disease+%28C7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=95 9&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cardiovascular and Non-Genetic Risk Factors for AD. T2 - 2008 Keystone Symposia on Alzheimer's Disease (C7) AN - 40806902; 4802269 JF - 2008 Keystone Symposia on Alzheimer's Disease (C7) AU - Launer, Lenore J Y1 - 2008/03/24/ PY - 2008 DA - 2008 Mar 24 KW - Cardiovascular diseases KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40806902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Alzheimer%27s+Disease+%28C7%29&rft.atitle=Cardiovascular+and+Non-Genetic+Risk+Factors+for+AD.&rft.au=Launer%2C+Lenore+J&rft.aulast=Launer&rft.aufirst=Lenore&rft.date=2008-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Alzheimer%27s+Disease+%28C7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=95 9&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Modeling the dynamics of inhomogeneous natural rotifer populations under toxicant exposure AN - 20764601; 8101153 AB - Most population models assume that individuals within a given population are identical, that is, the fundamental role of variation is ignored. Here we develop a general approach to modeling heterogeneous populations with discrete evolutionary time step. The theory is applied to models of natural rotifer population dynamics. We show that under particular conditions the behavior of the inhomogeneous model possesses complex transition regimes, which depends both on the mean and the variance of the initial parameter distribution; the final state of the population depends on the least possible value from the domain of the parameter. The question of population persistence is discussed. JF - Ecological Modelling AU - Karev, G P AU - Novozhilov, A S AU - Berezovskaya, F S AD - National Center for Biotechnology Information, Bethesda, MD 20894, USA, karev@ncbi.nlm.nih.gov Y1 - 2008/03/24/ PY - 2008 DA - 2008 Mar 24 SP - 80 EP - 85 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 212 IS - 1-2 SN - 0304-3800, 0304-3800 KW - Toxicology Abstracts; Sustainability Science Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Mathematical models KW - Toxicants KW - Population dynamics KW - Rotifera KW - Evolution KW - Models KW - Modelling KW - M3 1010:Issues in Sustainable Development KW - D 04030:Models, Methods, Remote Sensing KW - Q1 08442:Population dynamics KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20764601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ecological+Modelling&rft.atitle=Modeling+the+dynamics+of+inhomogeneous+natural+rotifer+populations+under+toxicant+exposure&rft.au=Karev%2C+G+P%3BNovozhilov%2C+A+S%3BBerezovskaya%2C+F+S&rft.aulast=Karev&rft.aufirst=G&rft.date=2008-03-24&rft.volume=212&rft.issue=1-2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Ecological+Modelling&rft.issn=03043800&rft_id=info:doi/10.1016%2Fj.ecolmodel.2007.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Population dynamics; Modelling; Mathematical models; Toxicants; Evolution; Models; Rotifera DO - http://dx.doi.org/10.1016/j.ecolmodel.2007.10.011 ER - TY - JOUR T1 - Volatile anesthetics and endogenous cannabinoid anandamide have additive and independent inhibitory effects on alpha(7)-nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. AN - 70303572; 18242598 AB - In earlier studies, the volatile anesthetics and the endogenous cannabinoid anandamide have been shown to inhibit the function of alpha(7)-nicotinic acetylcholine receptors. In the present study, interactions between the effects of volatile anesthetics and anandamide on the function of alpha(7)-nicotinic acetylcholine receptors expressed in Xenopus oocytes were investigated using the two-electrode voltage-clamp technique. Anandamide and volatile anesthetics isoflurane and halothane inhibited currents evoked with acetylcholine (100 microM) in a reversible and concentration-dependent manner. Coapplication of anandamide and volatile anesthetics caused a significantly greater inhibition of alpha(7)-nicotinic acetylcholine receptor function than anandamide or volatile anesthetics alone. Analyses of oocytes by matrix-assisted laser desorption/ionization mass spectroscopy indicated that volatile anesthetics did not alter the lipid profile of oocytes. Results of studies with chimeric alpha(7)-nicotinic acetylcholine-5-HT(3) receptors comprised of the N-terminal domain of the alpha(7)-nicotinic acetylcholine receptor and the transmembrane and carboxyl-terminal domains of 5-HT(3) receptors suggest that while isoflurane inhibition of the alpha(7)-nicotinic acetylcholine receptor is likely to involve the N-terminal region of the receptor, the site of action for anandamide involves transmembrane and carboxyl-terminal domains of the receptors. These data indicate that endocannabinoids and isoflurane have additive inhibitory effects on alpha(7)-nicotinic acetylcholine receptor function through allosteric binding sites located on the distinct regions of the receptor. JF - European journal of pharmacology AU - Jackson, Shelley N AU - Singhal, Sachin K AU - Woods, Amina S AU - Morales, Marisela AU - Shippenberg, Toni AU - Zhang, Li AU - Oz, Murat AD - National Institute on Drug Abuse, Baltimore, MD 21224, USA. Y1 - 2008/03/17/ PY - 2008 DA - 2008 Mar 17 SP - 42 EP - 51 VL - 582 IS - 1-3 SN - 0014-2999, 0014-2999 KW - Anesthetics, Inhalation KW - 0 KW - Arachidonic Acids KW - Cannabinoid Receptor Modulators KW - Endocannabinoids KW - Nicotinic Antagonists KW - Polyunsaturated Alkamides KW - Receptors, Nicotinic KW - alpha7 Nicotinic Acetylcholine Receptor KW - Isoflurane KW - CYS9AKD70P KW - Halothane KW - UQT9G45D1P KW - anandamide KW - UR5G69TJKH KW - Index Medicus KW - Xenopus laevis KW - Animals KW - Halothane -- pharmacology KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Drug Synergism KW - Isoflurane -- pharmacology KW - Female KW - Cannabinoid Receptor Modulators -- pharmacology KW - Polyunsaturated Alkamides -- pharmacology KW - Anesthetics, Inhalation -- pharmacology KW - Oocytes -- drug effects KW - Nicotinic Antagonists -- pharmacology KW - Receptors, Nicotinic -- drug effects KW - Oocytes -- physiology KW - Receptors, Nicotinic -- physiology KW - Arachidonic Acids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70303572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Volatile+anesthetics+and+endogenous+cannabinoid+anandamide+have+additive+and+independent+inhibitory+effects+on+alpha%287%29-nicotinic+acetylcholine+receptor-mediated+responses+in+Xenopus+oocytes.&rft.au=Jackson%2C+Shelley+N%3BSinghal%2C+Sachin+K%3BWoods%2C+Amina+S%3BMorales%2C+Marisela%3BShippenberg%2C+Toni%3BZhang%2C+Li%3BOz%2C+Murat&rft.aulast=Jackson&rft.aufirst=Shelley&rft.date=2008-03-17&rft.volume=582&rft.issue=1-3&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/10.1016%2Fj.ejphar.2007.12.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Synapse. 2002 Dec 1;46(3):150-6 [12325042] Brain Res Brain Res Rev. 2004 Dec;47(1-3):71-95 [15572164] Brain Res. 2002 Nov 1;954(1):73-81 [12393235] Chem Phys Lipids. 2002 Dec 31;121(1-2):135-48 [12505696] Curr Drug Targets CNS Neurol Disord. 2003 Apr;2(2):123-9 [12769804] Int Rev Neurobiol. 2003;54:1-50 [12785284] J Pharmacol Exp Ther. 2005 Jun;313(3):1272-80 [15687372] J Neurosci. 2005 Aug 17;25(33):7499-506 [16107637] Anesthesiology. 2006 Feb;104(2):273-7 [16436846] Curr Pharm Des. 2006;12(2):227-39 [16454739] Mol Pharmacol. 2006 Mar;69(3):991-7 [16332990] Int J Biochem Cell Biol. 2006;38(8):1254-76 [16520081] Biochemistry. 2007 Mar 20;46(11):3503-12 [17319650] Brain Res. 2003 Jul 18;978(1-2):194-204 [12834914] Br J Pharmacol. 2003 Jul;139(5):1005-13 [12839875] Mol Pharmacol. 2003 Aug;64(2):373-81 [12869642] J Pharmacol Exp Ther. 2003 Sep;306(3):1003-10 [12766252] Science. 2004 Apr 9;304(5668):265-70 [15031437] J Pharmacol Exp Ther. 2004 Jun;309(3):987-94 [14978193] J Neurosci Methods. 2004 Aug 30;137(2):167-73 [15262057] Br J Pharmacol. 2000 Jan;129(2):227-30 [10694225] Chem Phys Lipids. 1999 Aug;101(1):65-79 [10810926] Eur J Pharmacol. 2000 Sep 15;404(1-2):13-20 [10980258] Chem Phys Lipids. 2000 Nov;108(1-2):53-70 [11106782] EMBO J. 2001 Jan 15;20(1-2):47-54 [11226154] Mol Pharmacol. 2001 Apr;59(4):732-43 [11259617] Annu Rev Pharmacol Toxicol. 2001;41:23-51 [11264449] Anesthesiology. 2001 Jul;95(1):144-53 [11465552] EMBO J. 2001 Dec 17;20(24):7033-40 [11742980] Arch Biochem Biophys. 2002 Feb 15;398(2):275-83 [11831860] Brain Res Bull. 2002 Jan 15;57(2):133-50 [11849819] J Biol Chem. 2002 Mar 22;277(12):10367-73 [11741933] Naunyn Schmiedebergs Arch Pharmacol. 2002 May;365(5):413-7 [12012028] Pharmacol Rev. 2002 Jun;54(2):161-202 [12037135] Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):287-99 [12052043] Anesth Analg. 2002 Jul;95(1):83-7, table of contents [12088948] Anesthesiology. 2002 Jul;97(1):192-8 [12131122] J Pharmacol Exp Ther. 2004 Sep;310(3):1152-60 [15102930] Eur J Pharmacol. 2004 Oct 11;502(1-2):47-58 [15464089] Biochim Biophys Acta. 1986 Apr 25;856(3):640-5 [2421772] CRC Crit Rev Biochem. 1987;22(4):317-87 [2449311] Life Sci. 1991;49(22):1651-7 [1943469] Nature. 1993 Dec 2;366(6454):479-83 [8247158] Biophys J. 1993 Dec;65(6):2614-21 [8312496] J Pharmacol Exp Ther. 1994 Nov;271(2):898-905 [7965811] Adv Pharmacol. 1994;31:323-31 [7873421] Anesthesiology. 1995 Mar;82(3):749-58 [7879943] J Neurosci. 1995 May;15(5 Pt 1):3679-87 [7751938] Neurosci Lett. 1995 Feb 17;186(2-3):91-4 [7777206] Br J Pharmacol. 1996 Apr;117(7):1507-15 [8730747] Am J Physiol. 1996 Feb;270(2 Pt 1):C636-44 [8779929] Neuropharmacology. 1996;35(7):983-91 [8938728] Prog Brain Res. 1996;109:125-37 [9009699] Br J Pharmacol. 1997 Feb;120(3):353-5 [9031735] Nature. 1997 Sep 25;389(6649):385-9 [9311780] Mol Pharmacol. 1998 Dec;54(6):1106-12 [9855640] Nat Neurosci. 1999 May;2(5):422-6 [10321245] Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303 [10487207] Anesthesiology. 2004 Dec;101(6):1417-21 [15564950] Br J Pharmacol. 2002 Nov;137(5):589-96 [12381672] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ejphar.2007.12.023 ER - TY - CPAPER T1 - Interplay between Cellular Methyl Metabolism and Adaptive Efflux during Chronic Arsenic Exposure in Human Cells. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40860370; 4813129 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Coppin, J AU - Waalkes, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Metabolism KW - Arsenic KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Interplay+between+Cellular+Methyl+Metabolism+and+Adaptive+Efflux+during+Chronic+Arsenic+Exposure+in+Human+Cells.&rft.au=Coppin%2C+J%3BWaalkes%2C+M&rft.aulast=Coppin&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aberrant Cytokeratin Expressions Associated with Arsenic-induced Malignant Transformation of Human Keratinocytes. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40860291; 4813123 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sun, Y AU - Pi, J. AU - Liu, J AU - Waalkes, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cytokeratin KW - Keratinocytes KW - Transformation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Aberrant+Cytokeratin+Expressions+Associated+with+Arsenic-induced+Malignant+Transformation+of+Human+Keratinocytes.&rft.au=Sun%2C+Y%3BPi%2C+J.%3BLiu%2C+J%3BWaalkes%2C+M&rft.aulast=Sun&rft.aufirst=Y&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Metal-Inducible Transcription by a Zinc-Finger Transcription Factor. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859731; 4813306 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Freedman, J H AU - Braithwaite, E K AU - Jin, Y Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Transcription factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Regulation+of+Metal-Inducible+Transcription+by+a+Zinc-Finger+Transcription+Factor.&rft.au=Freedman%2C+J+H%3BBraithwaite%2C+E+K%3BJin%2C+Y&rft.aulast=Freedman&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of JS-K and PABA/NO, Novel Anti-Tumor Nitric Oxide Releasing Prodrugs, in Human Hepatoma HepB3 Cells. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859263; 4813160 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Liu, J AU - Wu, Q. AU - Keefer, L K AU - Saavedra, J E AU - Waalkes, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Nitric oxide KW - Hepatoma KW - Prodrugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Effects+of+JS-K+and+PABA%2FNO%2C+Novel+Anti-Tumor+Nitric+Oxide+Releasing+Prodrugs%2C+in+Human+Hepatoma+HepB3+Cells.&rft.au=Liu%2C+J%3BWu%2C+Q.%3BKeefer%2C+L+K%3BSaavedra%2C+J+E%3BWaalkes%2C+M&rft.aulast=Liu&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental Influence on Female Puberty and Breast Tumorigenesis. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40859082; 4813313 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Maull, E A AU - Lynch, S AU - Winn, D AU - Collman, G AU - Reinlib, L Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Tumorigenesis KW - Puberty KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Environmental+Influence+on+Female+Puberty+and+Breast+Tumorigenesis.&rft.au=Maull%2C+E+A%3BLynch%2C+S%3BWinn%2C+D%3BCollman%2C+G%3BReinlib%2C+L&rft.aulast=Maull&rft.aufirst=E&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Breast Cancer and the Environment Research Centers: A Novel Transdisciplinary Approach to Understanding the Causes and Mechanisms of Breast Cancer. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858280; 4813312 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Winn, D AU - Maull, E A AU - Collman, G AU - Reinlib, L AU - Lynch, S Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Breast+Cancer+and+the+Environment+Research+Centers%3A+A+Novel+Transdisciplinary+Approach+to+Understanding+the+Causes+and+Mechanisms+of+Breast+Cancer.&rft.au=Winn%2C+D%3BMaull%2C+E+A%3BCollman%2C+G%3BReinlib%2C+L%3BLynch%2C+S&rft.aulast=Winn&rft.aufirst=D&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potential Generation of Cancer Stem Cells during Arsenic-Induced Malignant Transformation of Human Urogenital Progenitor Cells. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40858003; 4813127 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Tokar, E J AU - Webber, M M AU - Waalkes, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cancer KW - Stem cells KW - Transformation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Potential+Generation+of+Cancer+Stem+Cells+during+Arsenic-Induced+Malignant+Transformation+of+Human+Urogenital+Progenitor+Cells.&rft.au=Tokar%2C+E+J%3BWebber%2C+M+M%3BWaalkes%2C+M&rft.aulast=Tokar&rft.aufirst=E&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Decoding of Human Liver Cancer. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40857796; 4813324 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Thorgeirsson, S S Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Liver cancer KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Genomic+Decoding+of+Human+Liver+Cancer.&rft.au=Thorgeirsson%2C+S+S&rft.aulast=Thorgeirsson&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NICEATM-ICCVAM Five Year Plan: Creating a Path Forward to Reduce, Refine and Replace Animal Testing T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40857654; 4813079 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Poland, A AU - Wind, M AU - Stokes, W AU - Allen, D AU - Fitzpatrick, S AU - Kulpa-Eddy, J AU - Hattan, D AU - Jacobs, A AU - McCarley, D AU - Rispin, A AU - Snyder, M AU - Sprankle, C AU - Tice, R AU - Winters, D Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+NICEATM-ICCVAM+Five+Year+Plan%3A+Creating+a+Path+Forward+to+Reduce%2C+Refine+and+Replace+Animal+Testing&rft.au=Poland%2C+A%3BWind%2C+M%3BStokes%2C+W%3BAllen%2C+D%3BFitzpatrick%2C+S%3BKulpa-Eddy%2C+J%3BHattan%2C+D%3BJacobs%2C+A%3BMcCarley%2C+D%3BRispin%2C+A%3BSnyder%2C+M%3BSprankle%2C+C%3BTice%2C+R%3BWinters%2C+D&rft.aulast=Poland&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro Cytotoxicity Test Methods for Estimating Rat Acute Oral Toxicity: Prediction of GHS Acute Oral Hazard Categories T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40847510; 4811928 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Paris, M AU - Strickland, J AU - Casati, S AU - Tice, R AU - Stokes, W Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity testing KW - Cytotoxicity KW - Acute toxicity KW - Bioaccumulation KW - Hazards KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40847510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=In+Vitro+Cytotoxicity+Test+Methods+for+Estimating+Rat+Acute+Oral+Toxicity%3A+Prediction+of+GHS+Acute+Oral+Hazard+Categories&rft.au=Paris%2C+M%3BStrickland%2C+J%3BCasati%2C+S%3BTice%2C+R%3BStokes%2C+W&rft.aulast=Paris&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Drinking Water Pre-conditioning on Toxicokinetics of Bromochloroacetic Acid (BCA) in Fischer 344 Rats and B6C3F1 Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40847403; 4811885 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Godfrey, V AU - Hong, S AU - Johnson, J D AU - Graves, S AU - Smith, C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Drinking water KW - Rats KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40847403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Effect+of+Drinking+Water+Pre-conditioning+on+Toxicokinetics+of+Bromochloroacetic+Acid+%28BCA%29+in+Fischer+344+Rats+and+B6C3F1+Mice&rft.au=Godfrey%2C+V%3BHong%2C+S%3BJohnson%2C+J+D%3BGraves%2C+S%3BSmith%2C+C&rft.aulast=Godfrey&rft.aufirst=V&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling the Effects of Chlorpyrifos on Caenorhabditis Elegans Growth and Development T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40845903; 4811908 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Boyd, W A AU - Smith, M V AU - Kissling, G E AU - McBride, S J AU - Rice, J R AU - Snyder, D W AU - Portier, C J AU - Freedman, J H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Pesticides KW - Chlorpyrifos KW - Growth rate KW - Caenorhabditis elegans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Modeling+the+Effects+of+Chlorpyrifos+on+Caenorhabditis+Elegans+Growth+and+Development&rft.au=Boyd%2C+W+A%3BSmith%2C+M+V%3BKissling%2C+G+E%3BMcBride%2C+S+J%3BRice%2C+J+R%3BSnyder%2C+D+W%3BPortier%2C+C+J%3BFreedman%2C+J+H&rft.aulast=Boyd&rft.aufirst=W&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NRF2-Mediated Signaling: Role in Lung Inflammation and Tumorigenesis. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40845656; 4813384 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Kleeberger, S R AU - Bauer, A K AU - Wang, X AU - Bell, D A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Signal transduction KW - Tumorigenesis KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=NRF2-Mediated+Signaling%3A+Role+in+Lung+Inflammation+and+Tumorigenesis.&rft.au=Kleeberger%2C+S+R%3BBauer%2C+A+K%3BWang%2C+X%3BBell%2C+D+A&rft.aulast=Kleeberger&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Procainamide, but not N-Acetylprocainamide, Induces Protein Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40845140; 4811566 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Siraki, A AU - Deterding, L AU - Bonini, M G AU - Jiang, J AU - Ehrenshaft, M AU - Mason, R P Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Radicals KW - Neutropenia KW - Peroxidase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40845140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Procainamide%2C+but+not+N-Acetylprocainamide%2C+Induces+Protein+Radical+Formation+on+Myeloperoxidase%3A+A+Potential+Mechanism+of+Agranulocytosis.&rft.au=Siraki%2C+A%3BDeterding%2C+L%3BBonini%2C+M+G%3BJiang%2C+J%3BEhrenshaft%2C+M%3BMason%2C+R+P&rft.aulast=Siraki&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Mechanisms of Susceptibility to Ozone-Induced Lung Injury: New Insights. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844841; 4813364 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Kleeberger, S R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Injuries KW - Ozonation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Genetic+Mechanisms+of+Susceptibility+to+Ozone-Induced+Lung+Injury%3A+New+Insights.&rft.au=Kleeberger%2C+S+R&rft.aulast=Kleeberger&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Centrosomal Amplification Induced by Antiretrovirals Commonly Used in the Therapy of HIV. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844788; 4811822 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Yu, M. AU - Poirier, M C AU - Olivero, O A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Antiretroviral agents KW - Human immunodeficiency virus KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Centrosomal+Amplification+Induced+by+Antiretrovirals+Commonly+Used+in+the+Therapy+of+HIV.&rft.au=Yu%2C+M.%3BPoirier%2C+M+C%3BOlivero%2C+O+A&rft.aulast=Yu&rft.aufirst=M.&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue Distribution of Chromium in Male Fischer 344 Rats and Female B6C3F1 Mice Exposed to Sodium Dichromate Dihydrate in Drinking Water for 2 Years. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844686; 4811793 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Collins, B J AU - Levine, K AU - Ross, G T AU - Fernando, R AU - Fennell, T R AU - Kissling, G E AU - Stout, M D AU - Hooth, M J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Sodium KW - Mice KW - Drinking water KW - Rats KW - Chromium KW - Sodium dichromate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Tissue+Distribution+of+Chromium+in+Male+Fischer+344+Rats+and+Female+B6C3F1+Mice+Exposed+to+Sodium+Dichromate+Dihydrate+in+Drinking+Water+for+2+Years.&rft.au=Collins%2C+B+J%3BLevine%2C+K%3BRoss%2C+G+T%3BFernando%2C+R%3BFennell%2C+T+R%3BKissling%2C+G+E%3BStout%2C+M+D%3BHooth%2C+M+J&rft.aulast=Collins&rft.aufirst=B&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carcinogenesis Studies of Cresols in Rats and Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844685; 4811791 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sanders, J M AU - Bucher, J R AU - Peckham, J C AU - Kissling, G E AU - Hejtmancik, M R AU - Chhabra, R S Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Carcinogenesis KW - Rats KW - Cresol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Carcinogenesis+Studies+of+Cresols+in+Rats+and+Mice&rft.au=Sanders%2C+J+M%3BBucher%2C+J+R%3BPeckham%2C+J+C%3BKissling%2C+G+E%3BHejtmancik%2C+M+R%3BChhabra%2C+R+S&rft.aulast=Sanders&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - V-PROLI/NO, a Nitric Oxide Donor Prodrug, Protects Liver Cells from Arsenic-Induced Toxicity and Apoptosis T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844680; 4811732 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Qu, W. AU - Dill, A AU - Saavedra, J E AU - Keefer, L K AU - Waalkes, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Liver KW - Nitric oxide KW - Apoptosis KW - Hepatocytes KW - Prodrugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=V-PROLI%2FNO%2C+a+Nitric+Oxide+Donor+Prodrug%2C+Protects+Liver+Cells+from+Arsenic-Induced+Toxicity+and+Apoptosis&rft.au=Qu%2C+W.%3BDill%2C+A%3BSaavedra%2C+J+E%3BKeefer%2C+L+K%3BWaalkes%2C+M&rft.aulast=Qu&rft.aufirst=W.&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inorganic Arsenite Induces Delayed Oxidative DNA Damage Dependent on Cellular Ability to Methylate Arsenic T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844565; 4811763 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Kojima, C AU - Waalkes, M AU - Ramirez, D AU - Mason, R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Arsenic KW - Arsenite KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Inorganic+Arsenite+Induces+Delayed+Oxidative+DNA+Damage+Dependent+on+Cellular+Ability+to+Methylate+Arsenic&rft.au=Kojima%2C+C%3BWaalkes%2C+M%3BRamirez%2C+D%3BMason%2C+R&rft.aulast=Kojima&rft.aufirst=C&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Repair of Radiation Induced DNA Strand Breaks in p53 Deficient and Wild-Type Mouse Hematopoietic Stem Cells is Strain Dependent T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40844024; 4811816 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - French, J E AU - Parron, V I Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Stem cells KW - Radiation KW - P53 protein KW - DNA damage KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40844024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Repair+of+Radiation+Induced+DNA+Strand+Breaks+in+p53+Deficient+and+Wild-Type+Mouse+Hematopoietic+Stem+Cells+is+Strain+Dependent&rft.au=French%2C+J+E%3BParron%2C+V+I&rft.aulast=French&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Skin Carcinoma Formation in Adult Mice Associated with Distorted Stem Cell Dynamics after in Utero Arsenic Exposure T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40843446; 4811762 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Waalkes, M AU - Liu, J AU - Germolec, D R AU - Ward, J M AU - Cannon, R E AU - Trempus, C S AU - Tennant, R W AU - Diwan, B A Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Stem cells KW - Skin KW - Mice KW - Arsenic KW - Skin carcinoma KW - Intrauterine exposure KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40843446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Increased+Skin+Carcinoma+Formation+in+Adult+Mice+Associated+with+Distorted+Stem+Cell+Dynamics+after+in+Utero+Arsenic+Exposure&rft.au=Waalkes%2C+M%3BLiu%2C+J%3BGermolec%2C+D+R%3BWard%2C+J+M%3BCannon%2C+R+E%3BTrempus%2C+C+S%3BTennant%2C+R+W%3BDiwan%2C+B+A&rft.aulast=Waalkes&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fumonisin B1 Exposure Phenocopies Cholesterol Deprivation in C. elegans T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40843224; 4811697 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - McElwee, M AU - Wise, A AU - Boyd, W A AU - Freedman, J H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cholesterol KW - Fumonisin B1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40843224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Fumonisin+B1+Exposure+Phenocopies+Cholesterol+Deprivation+in+C.+elegans&rft.au=McElwee%2C+M%3BWise%2C+A%3BBoyd%2C+W+A%3BFreedman%2C+J+H&rft.aulast=McElwee&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity and Carcinogenicity of Chromium Following Chronic Oral Exposure: Dependence on Valence State and Tissue Uptake T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40842961; 4811792 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Stout, M D AU - Collins, B J AU - Herbert, R A AU - Nyska, A AU - Kissling, G E AU - Levine, K AU - Ross, G T AU - Hebert, C D AU - Travlos, G S AU - Bucher, J R AU - Hooth, M J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Carcinogenicity KW - Chromium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Toxicity+and+Carcinogenicity+of+Chromium+Following+Chronic+Oral+Exposure%3A+Dependence+on+Valence+State+and+Tissue+Uptake&rft.au=Stout%2C+M+D%3BCollins%2C+B+J%3BHerbert%2C+R+A%3BNyska%2C+A%3BKissling%2C+G+E%3BLevine%2C+K%3BRoss%2C+G+T%3BHebert%2C+C+D%3BTravlos%2C+G+S%3BBucher%2C+J+R%3BHooth%2C+M+J&rft.aulast=Stout&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MTF-1 and CARM1 may Cooperate to Regulate Metallothionein Expression and Metal Homeostasis T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841926; 4811740 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Braithwaite, E AU - Freedman, J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Metallothionein KW - Metals KW - Homeostasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=MTF-1+and+CARM1+may+Cooperate+to+Regulate+Metallothionein+Expression+and+Metal+Homeostasis&rft.au=Braithwaite%2C+E%3BFreedman%2C+J&rft.aulast=Braithwaite&rft.aufirst=E&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cadmium-Induced Malignant Transformation of Human Breast Epithelial Cells T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841833; 4811747 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Benbrahim-Tallaa, L AU - Coppin, J AU - Liu, J AU - Diwan, B A AU - Waalkes, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Epithelial cells KW - Transformation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Cadmium-Induced+Malignant+Transformation+of+Human+Breast+Epithelial+Cells&rft.au=Benbrahim-Tallaa%2C+L%3BCoppin%2C+J%3BLiu%2C+J%3BDiwan%2C+B+A%3BWaalkes%2C+M&rft.aulast=Benbrahim-Tallaa&rft.aufirst=L&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heterologous Expression System in Yeast Revealed Structure-Function Relationship in Metal Transcription Factor, MTF-1 T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841782; 4811705 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Jin, Y AU - Al-Refai, H AU - Freedman, J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Metals KW - Structure-function relationships KW - Transcription factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Heterologous+Expression+System+in+Yeast+Revealed+Structure-Function+Relationship+in+Metal+Transcription+Factor%2C+MTF-1&rft.au=Jin%2C+Y%3BAl-Refai%2C+H%3BFreedman%2C+J&rft.aulast=Jin&rft.aufirst=Y&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Caenorhabditis Elegans Gene, Numr-1, Assembles into Nuclear Stress Granules after Cadmium Treatment T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841450; 4811744 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Tvermoes, B AU - Freedman, J H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Stress KW - Cadmium KW - Granules KW - Pollution effects KW - Caenorhabditis elegans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Caenorhabditis+Elegans+Gene%2C+Numr-1%2C+Assembles+into+Nuclear+Stress+Granules+after+Cadmium+Treatment&rft.au=Tvermoes%2C+B%3BFreedman%2C+J+H&rft.aulast=Tvermoes&rft.aufirst=B&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aminolevulinic Acid Dehydratase (ALAD) Polymorphism is Associated with Blood Lead Level and Hypertension in the National Health and Nutrition Examination Survey (NHANES III). T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40841413; 4812675 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Scinicariello, F AU - Fowler, B A AU - Yesupriya, A AU - Chang, M Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Hypertension KW - Blood levels KW - Nutrition KW - Lead KW - Aminolevulinic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40841413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Aminolevulinic+Acid+Dehydratase+%28ALAD%29+Polymorphism+is+Associated+with+Blood+Lead+Level+and+Hypertension+in+the+National+Health+and+Nutrition+Examination+Survey+%28NHANES+III%29.&rft.au=Scinicariello%2C+F%3BFowler%2C+B+A%3BYesupriya%2C+A%3BChang%2C+M&rft.aulast=Scinicariello&rft.aufirst=F&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of Autophagy in Porcine Kidney Cells by Quantum Dots T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40840310; 4812199 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Stern, S T AU - Zolnik, B S AU - Zheng, J AU - McNeil, S E Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Kidneys KW - Phagocytosis KW - Quantum dots KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40840310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Activation+of+Autophagy+in+Porcine+Kidney+Cells+by+Quantum+Dots&rft.au=Stern%2C+S+T%3BZolnik%2C+B+S%3BZheng%2C+J%3BMcNeil%2C+S+E&rft.aulast=Stern&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanomaterial Pharmacokinetics and Pharmacokinetic Modeling: Where We are and Where We Need to Go. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839827; 4813376 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Walker, N Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Pharmacokinetics KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Nanomaterial+Pharmacokinetics+and+Pharmacokinetic+Modeling%3A+Where+We+are+and+Where+We+Need+to+Go.&rft.au=Walker%2C+N&rft.aulast=Walker&rft.aufirst=N&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Performance Characteristics of the Local Lymph Node Assay (LLNA) Limit Dose Procedure. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839523; 4812291 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Stokes, W AU - Allen, D AU - Burns, T AU - Choksi, N AU - Matheson, J AU - Jacobs, A AU - Tice, R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lymph nodes KW - Local lymph node assay KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Performance+Characteristics+of+the+Local+Lymph+Node+Assay+%28LLNA%29+Limit+Dose+Procedure.&rft.au=Stokes%2C+W%3BAllen%2C+D%3BBurns%2C+T%3BChoksi%2C+N%3BMatheson%2C+J%3BJacobs%2C+A%3BTice%2C+R&rft.aulast=Stokes&rft.aufirst=W&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutations in Cancer Genes in Lung Tumors from Swiss (CD-1) Mice Exposed Transplacentally to AZT Affect Similar Molecular Pathways that are Important in Human Lung Cancer. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839302; 4813401 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Sills, R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung cancer KW - Mutation KW - Mice KW - Tumors KW - Zidovudine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Mutations+in+Cancer+Genes+in+Lung+Tumors+from+Swiss+%28CD-1%29+Mice+Exposed+Transplacentally+to+AZT+Affect+Similar+Molecular+Pathways+that+are+Important+in+Human+Lung+Cancer.&rft.au=Sills%2C+R&rft.aulast=Sills&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation and Individual Susceptibility to Environmental Exposure and Disease. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40839003; 4813426 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - French, J E Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Genetic diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Genetic+Variation+and+Individual+Susceptibility+to+Environmental+Exposure+and+Disease.&rft.au=French%2C+J+E&rft.aulast=French&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perinatal Nucleoside Reverse Transcriptase Inhibitor (NRTI) Exposures Cause Persistent Mitochondrial Compromise in Mouse and Monkey Offspring and Human infants. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40838290; 4813398 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Divi, R L AU - St Claire, M C AU - Walker, D M AU - Walker, V E AU - Poirier, M C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Offspring KW - Infants KW - Progeny KW - Mitochondria KW - Perinatal exposure KW - Nucleoside reverse transcriptase inhibitors KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Perinatal+Nucleoside+Reverse+Transcriptase+Inhibitor+%28NRTI%29+Exposures+Cause+Persistent+Mitochondrial+Compromise+in+Mouse+and+Monkey+Offspring+and+Human+infants.&rft.au=Divi%2C+R+L%3BSt+Claire%2C+M+C%3BWalker%2C+D+M%3BWalker%2C+V+E%3BPoirier%2C+M+C&rft.aulast=Divi&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Inflammatory Gene Expression in Young and Aged Mice during Chemical Injury-Induced Hippocampal Neurogenesis. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40838145; 4812807 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - McPherson, C A AU - Aoyama, M AU - Grissom, S F AU - Gohlke, J AU - Harry, G J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Gene expression KW - Neurogenesis KW - Inflammation KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Differential+Inflammatory+Gene+Expression+in+Young+and+Aged+Mice+during+Chemical+Injury-Induced+Hippocampal+Neurogenesis.&rft.au=McPherson%2C+C+A%3BAoyama%2C+M%3BGrissom%2C+S+F%3BGohlke%2C+J%3BHarry%2C+G+J&rft.aulast=McPherson&rft.aufirst=C&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decreased Incidences of Neoplasms and Non-Neoplastic Lesions in F344/N Rats and B6C3F1 Mice Fed Milk Thistle Extracts for Two Years. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837748; 4812629 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Singh, B AU - Nyska, A AU - Roycroft, A AU - Malarkey, D E AU - Dunnick, J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Lesions KW - Rats KW - Milk KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Decreased+Incidences+of+Neoplasms+and+Non-Neoplastic+Lesions+in+F344%2FN+Rats+and+B6C3F1+Mice+Fed+Milk+Thistle+Extracts+for+Two+Years.&rft.au=Singh%2C+B%3BNyska%2C+A%3BRoycroft%2C+A%3BMalarkey%2C+D+E%3BDunnick%2C+J&rft.aulast=Singh&rft.aufirst=B&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Metallothionein in Porcine Kidney Cells by Quantum Dots T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837348; 4812200 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - McLeland, C B AU - McLeland, S E AU - Stern, S T Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Metallothionein KW - Kidneys KW - Quantum dots KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Induction+of+Metallothionein+in+Porcine+Kidney+Cells+by+Quantum+Dots&rft.au=McLeland%2C+C+B%3BMcLeland%2C+S+E%3BStern%2C+S+T&rft.aulast=McLeland&rft.aufirst=C&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Genetic Basis for Susceptibility to Environmental Lung Diseases in Mouse and Humans. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40837059; 4813427 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Kleeberger, S R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40837059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Genetic+Basis+for+Susceptibility+to+Environmental+Lung+Diseases+in+Mouse+and+Humans.&rft.au=Kleeberger%2C+S+R&rft.aulast=Kleeberger&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biphasic Regulation of Il2 Gene Expression in Naive CD4+ T Cells: Rate Limiting Roles for TNF-a Receptor Signaling and Chromatin Structure. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836677; 4812575 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Mckarns, S C AU - Schwartz, R H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Signal transduction KW - Interleukin 2 KW - Tumor necrosis factor-a KW - Chromatin KW - Lymphocytes T KW - CD4 antigen KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Biphasic+Regulation+of+Il2+Gene+Expression+in+Naive+CD4%2B+T+Cells%3A+Rate+Limiting+Roles+for+TNF-a+Receptor+Signaling+and+Chromatin+Structure.&rft.au=Mckarns%2C+S+C%3BSchwartz%2C+R+H&rft.aulast=Mckarns&rft.aufirst=S&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tetramethoxystilbene (TMS), a Potent Cytochrome P450 (CYP) 1A1/1B1 Inhibitor, Enhanced Benzo(a)Pyrene (BP)-DNA Adduct Formation in MCF-7 Cells T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836405; 4812901 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Einem, T L AU - Divi, R L AU - Chu, Y AU - Poirier, M C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Cytochrome P450 KW - Adducts KW - Benzo(a)pyrene KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Tetramethoxystilbene+%28TMS%29%2C+a+Potent+Cytochrome+P450+%28CYP%29+1A1%2F1B1+Inhibitor%2C+Enhanced+Benzo%28a%29Pyrene+%28BP%29-DNA+Adduct+Formation+in+MCF-7+Cells&rft.au=Einem%2C+T+L%3BDivi%2C+R+L%3BChu%2C+Y%3BPoirier%2C+M+C&rft.aulast=Einem&rft.aufirst=T&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perinatal Exposure to Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Induces Transplacental Genotoxicity and Mitochondrial Toxicity. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836095; 4813397 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Poirier, M C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Toxicity KW - Genotoxicity KW - Mitochondria KW - Perinatal exposure KW - Nucleoside reverse transcriptase inhibitors KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Perinatal+Exposure+to+Nucleoside+Reverse+Transcriptase+Inhibitors+%28NRTIs%29+Induces+Transplacental+Genotoxicity+and+Mitochondrial+Toxicity.&rft.au=Poirier%2C+M+C&rft.aulast=Poirier&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Gene/Pathway/Disease Analysis to Quantify Critical Disease Pathways. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40836085; 4813501 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Portier, C J AU - Gohlke, J AU - Thomas, R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40836085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Using+Gene%2FPathway%2FDisease+Analysis+to+Quantify+Critical+Disease+Pathways.&rft.au=Portier%2C+C+J%3BGohlke%2C+J%3BThomas%2C+R&rft.aulast=Portier&rft.aufirst=C&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Toxicology of Transition Metals: From Yeast to Man. T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835874; 4813412 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Freedman, J H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Transition metals KW - Heavy metals KW - Toxicology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Molecular+Toxicology+of+Transition+Metals%3A+From+Yeast+to+Man.&rft.au=Freedman%2C+J+H&rft.aulast=Freedman&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Progressive Pulmonary and Pleural Effects of Indium Phosphide in B6c3f1 Mice: Particulate Induced Pleural Fibrosis and Proliferation T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40835143; 4812027 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Kirby, P AU - Shines, C AU - Taylor, G AU - Bousquet, R AU - Price, H AU - Everitt, J AU - Morgan, D Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Particulates KW - Indium KW - Mice KW - Lung KW - Fibrosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Progressive+Pulmonary+and+Pleural+Effects+of+Indium+Phosphide+in+B6c3f1+Mice%3A+Particulate+Induced+Pleural+Fibrosis+and+Proliferation&rft.au=Kirby%2C+P%3BShines%2C+C%3BTaylor%2C+G%3BBousquet%2C+R%3BPrice%2C+H%3BEveritt%2C+J%3BMorgan%2C+D&rft.aulast=Kirby&rft.aufirst=P&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Global Transcriptome Changes in HepG2 Cells Exposed to Copper T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40833016; 4811501 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Song, M AU - Freedman, J H Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Copper KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40833016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Global+Transcriptome+Changes+in+HepG2+Cells+Exposed+to+Copper&rft.au=Song%2C+M%3BFreedman%2C+J+H&rft.aulast=Song&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered GABAergic Neurotransmission is Associated with Increased Susceptibility to NMDA-Induced Excitotoxicity in Cyclooxygenase-2 Deficient Mice T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832612; 4811364 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Toscano, C D AU - Vicini, S AU - Bosetti, F Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mice KW - Excitotoxicity KW - Neurotransmission KW - Cyclooxygenase-2 KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Altered+GABAergic+Neurotransmission+is+Associated+with+Increased+Susceptibility+to+NMDA-Induced+Excitotoxicity+in+Cyclooxygenase-2+Deficient+Mice&rft.au=Toscano%2C+C+D%3BVicini%2C+S%3BBosetti%2C+F&rft.aulast=Toscano&rft.aufirst=C&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Genetic and Environmental Pathways to Complex Diseases T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832363; 4811482 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Gohlke, J M AU - Thomas, R AU - Zhang, Y AU - Rosenstein, M C AU - Davis, A P AU - Murphy, C AU - Mattingly, C J AU - Becker, K G AU - Portier, C J Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Bioinformatics KW - Toxicology KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=The+Genetic+and+Environmental+Pathways+to+Complex+Diseases&rft.au=Gohlke%2C+J+M%3BThomas%2C+R%3BZhang%2C+Y%3BRosenstein%2C+M+C%3BDavis%2C+A+P%3BMurphy%2C+C%3BMattingly%2C+C+J%3BBecker%2C+K+G%3BPortier%2C+C+J&rft.aulast=Gohlke&rft.aufirst=J&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Iron Clearance in the Cerebrospinal (CSF) of Rat Brains as Affected by Manganese Exposure by Ventriculo-Cisternal Brain Perfusion T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40832274; 4811311 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Wang, X AU - Zhang, Y AU - Zheng, W Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Brain KW - Manganese KW - Iron KW - Perfusion KW - Cerebrospinal fluid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Iron+Clearance+in+the+Cerebrospinal+%28CSF%29+of+Rat+Brains+as+Affected+by+Manganese+Exposure+by+Ventriculo-Cisternal+Brain+Perfusion&rft.au=Wang%2C+X%3BZhang%2C+Y%3BZheng%2C+W&rft.aulast=Wang&rft.aufirst=X&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age-Related Hepatic Gene Expression Alterations in Immune System Pathways in the Fischer Rat T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40831832; 4811495 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Frawley, R AU - Germolec, D AU - Lobenhofer, E K AU - Parker, J AU - Boorman, G AU - Irwin, R Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Immune system KW - Gene expression KW - Liver KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40831832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Age-Related+Hepatic+Gene+Expression+Alterations+in+Immune+System+Pathways+in+the+Fischer+Rat&rft.au=Frawley%2C+R%3BGermolec%2C+D%3BLobenhofer%2C+E+K%3BParker%2C+J%3BBoorman%2C+G%3BIrwin%2C+R&rft.aulast=Frawley&rft.aufirst=R&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of an Organotypic Culture System to Study the Actions of Microglia in the Presence of Neurons Expressing Mutant Huntingtin Protein Fragments T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40830785; 4811373 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Kraft, A D AU - Turmel, G J AU - Lo, D C AU - Harry, G Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Mutants KW - Microglia KW - Huntingtin KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40830785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Use+of+an+Organotypic+Culture+System+to+Study+the+Actions+of+Microglia+in+the+Presence+of+Neurons+Expressing+Mutant+Huntingtin+Protein+Fragments&rft.au=Kraft%2C+A+D%3BTurmel%2C+G+J%3BLo%2C+D+C%3BHarry%2C+G&rft.aulast=Kraft&rft.aufirst=A&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon Nanotubes and Bacterial Lipopolysaccharide (LPS) Act Coordinately to Stimulate Platelet-Derived Growth Factor (PDGF) Signaling and Lung Fibrosis in Rats T2 - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AN - 40830552; 4812166 JF - 47th Annual Meeting of the Society of Toxicology (SOT 2008) AU - Cesta, M F AU - Ryman-Rasmussen, J P AU - Wallace, D G AU - Bonner, J C Y1 - 2008/03/16/ PY - 2008 DA - 2008 Mar 16 KW - Lung KW - Nanotechnology KW - Growth factors KW - Rats KW - Platelet-derived growth factor KW - Lipopolysaccharides KW - Signal transduction KW - Carbon KW - Fibrosis KW - Nanotubes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40830552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.atitle=Carbon+Nanotubes+and+Bacterial+Lipopolysaccharide+%28LPS%29+Act+Coordinately+to+Stimulate+Platelet-Derived+Growth+Factor+%28PDGF%29+Signaling+and+Lung+Fibrosis+in+Rats&rft.au=Cesta%2C+M+F%3BRyman-Rasmussen%2C+J+P%3BWallace%2C+D+G%3BBonner%2C+J+C&rft.aulast=Cesta&rft.aufirst=M&rft.date=2008-03-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2008/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Impaired intracortical inhibition in the primary somatosensory cortex in focal hand dystonia. AN - 742775644; pmid-18074393 AB - Somesthetic temporal discrimination (STD) is impaired in focal hand dystonia (FHD). We explored the electrophysiological correlate of the STD deficit to assess whether this is due to dysfunction of temporal inhibition in the somatosensory inhibitory pathway or due to dysfunction in structures responsible for nonmodality-specific timing integration. Eleven FHD patients and 11 healthy volunteers were studied. STD threshold was investigated as the time interval required for perceiving a pair of stimuli as two separate stimuli in time. We also examined the somatosensory-evoked potential (SEP) in a paired-pulse paradigm. We compared STD threshold and recovery function of SEP between the groups. STD thresholds were significantly greater in FHD than in healthy volunteers. The amount of P27 suppression in the 5 ms-ISI condition was significantly less in FHD. It was also found that the STD threshold and P27 suppression were significantly correlated: the greater the STD threshold, the less the P27 suppression. Significantly less suppression of P27 with a lack of significant change in N20 indicates that the impairment of somatosensory information processing in the time domain is due to dysfunction within the primary somatosensory cortex, suggesting that that the STD deficit in FHD is more attributable to dysfunction in the somatosensory pathway. (c) 2007 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Tamura, Yohei AU - Matsuhashi, Masao AU - Lin, Peter AU - Ou, Bai AU - Vorbach, Sherry AU - Kakigi, Ryusuke AU - Hallett, Mark AD - Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA. Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 558 EP - 565 VL - 23 IS - 4 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Neural Pathways -- physiopathology KW - Humans KW - Evoked Potentials -- physiology KW - Visual Perception -- physiology KW - Time Perception -- physiology KW - Auditory Perception -- physiology KW - Adult KW - Disability Evaluation KW - Thalamus -- physiopathology KW - Middle Aged KW - Male KW - Female KW - Hand -- physiopathology KW - Somatosensory Cortex -- physiopathology KW - Dystonia -- physiopathology KW - Neural Inhibition -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742775644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Impaired+intracortical+inhibition+in+the+primary+somatosensory+cortex+in+focal+hand+dystonia.&rft.au=Tamura%2C+Yohei%3BMatsuhashi%2C+Masao%3BLin%2C+Peter%3BOu%2C+Bai%3BVorbach%2C+Sherry%3BKakigi%2C+Ryusuke%3BHallett%2C+Mark&rft.aulast=Tamura&rft.aufirst=Yohei&rft.date=2008-03-15&rft.volume=23&rft.issue=4&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Mycosis fungoides and Sézary syndrome. AN - 70405069; 18342689 AB - Mycosis fungoides and Sézary syndrome are the most common of the cutaneous T-cell lymphomas, which are a heterogeneous group of neoplasms that affect the skin as a primary site. Although the aetiologies of mycosis fungoides and Sézary syndrome are unknown, important insights have been gained in the immunological and genetic perturbations that are associated with these diseases. Unlike some B-cell lymphomas, cutaneous T-cell lymphomas as a group are rarely if ever curable and hence need chronic-disease management. New approaches to treatments are being investigated and include biological and cytotoxic drugs, phototherapy, and monoclonal antibodies that are directed towards novel molecular targets. New molecular technologies such as complementary-DNA microarray have the potential to increase the accuracy of diagnosis and provide important prognostic information. Treatments can be combined to greatly improve clinical outcome without substantially increasing toxic effects in advanced disease that is otherwise difficult to treat. Although present treatment strategies are generally not curative, there is hope that experimental treatments, particularly immunotherapy, might eventually reverse or suppress the abnormalities of mycosis fungoides and Sézary syndrome to the point at which they become non-life-threatening, chronic diseases. JF - Lancet (London, England) AU - Hwang, Sam T AU - Janik, John E AU - Jaffe, Elaine S AU - Wilson, Wyndham H AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA. hwangs@mail.nih.gov Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 945 EP - 957 VL - 371 IS - 9616 KW - Cytokines KW - 0 KW - Toll-Like Receptors KW - Abridged Index Medicus KW - Index Medicus KW - Cytokines -- therapeutic use KW - Humans KW - Immunotherapy, Active KW - Toll-Like Receptors -- agonists KW - Skin Neoplasms -- genetics KW - Skin Neoplasms -- physiopathology KW - Mycosis Fungoides -- therapy KW - Mycosis Fungoides -- physiopathology KW - Sezary Syndrome -- genetics KW - Sezary Syndrome -- therapy KW - Skin Neoplasms -- therapy KW - Mycosis Fungoides -- genetics KW - Sezary Syndrome -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70405069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Mycosis+fungoides+and+S%C3%A9zary+syndrome.&rft.au=Hwang%2C+Sam+T%3BJanik%2C+John+E%3BJaffe%2C+Elaine+S%3BWilson%2C+Wyndham+H&rft.aulast=Hwang&rft.aufirst=Sam&rft.date=2008-03-15&rft.volume=371&rft.issue=9616&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/10.1016%2FS0140-6736%2808%2960420-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0140-6736(08)60420-1 ER - TY - JOUR T1 - Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme: a report from the EORTC 26981/22981 NCI-C CE3 Intergroup Study. AN - 70379167; 18213621 AB - The study aimed to compare the cost-effectiveness of concomitant and adjuvant temozolomide (TMZ) for the treatment of newly diagnosed glioblastoma multiforme versus initial radiotherapy alone from a public health care perspective. The economic evaluation was performed alongside a randomized, multicenter, phase 3 trial. The primary endpoint of the trial was overall survival. Costs included all direct medical costs. Economic data were collected prospectively for a subgroup of 219 patients (38%). Unit costs for drugs, procedures, laboratory and imaging, radiotherapy, and hospital costs per day were collected from the official national reimbursement lists based on 2004. For the cost-effectiveness analysis, survival was expressed as 2.5 years restricted mean estimates. The incremental cost-effectiveness ratio (ICER) was constructed. Confidence intervals for the ICER were calculated using the Fieller method and bootstrapping. The difference in 2.5 years restricted mean survival between the treatment arms was 0.25 life-years and the ICER was euro37,361 per life-year gained with a 95% confidence interval (CI) ranging from euro19,544 to euro123,616. The area between the survival curves of the treatment arms suggests an increase of the overall survival gain for a longer follow-up. An extrapolation of the overall survival per treatment arm and imputation of costs for the extrapolated survival showed a substantial reduction in ICER. The ICER of euro37,361 per life-year gained is a conservative estimate. We concluded that despite the high TMZ acquisition costs, the costs per life-year gained are comparable to accepted first-line treatment with chemotherapy in patients with cancer. Copyright (c) 2008 American Cancer Society. JF - Cancer AU - Lamers, Leida M AU - Stupp, Roger AU - van den Bent, Martin J AU - Al, Maiwenn J AU - Gorlia, Thierry AU - Wasserfallen, Jean-Blaise AU - Mittmann, Nicole AU - Jin Seung, Soo AU - Crott, Ralph AU - Uyl-de Groot, Carin A AU - EORTC 26981/22981 NCI-C CE3 Intergroup Study AD - Institute for Medical Technology Assessment bv, Erasmus University Medical Center, Rotterdam, Netherlands. ; EORTC 26981/22981 NCI-C CE3 Intergroup Study Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 1337 EP - 1344 VL - 112 IS - 6 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents, Alkylating KW - 0 KW - Dacarbazine KW - 7GR28W0FJI KW - temozolomide KW - YF1K15M17Y KW - Abridged Index Medicus KW - Index Medicus KW - Quality-Adjusted Life Years KW - Disease-Free Survival KW - Survival Rate KW - Humans KW - Cost-Benefit Analysis KW - Adult KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Health Care Costs KW - Dacarbazine -- therapeutic use KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Brain Neoplasms -- economics KW - Brain Neoplasms -- drug therapy KW - Glioblastoma -- radiotherapy KW - Dacarbazine -- analogs & derivatives KW - Brain Neoplasms -- radiotherapy KW - Glioblastoma -- economics KW - Glioblastoma -- drug therapy KW - Dacarbazine -- economics KW - Antineoplastic Agents, Alkylating -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70379167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Cost-effectiveness+of+temozolomide+for+the+treatment+of+newly+diagnosed+glioblastoma+multiforme%3A+a+report+from+the+EORTC+26981%2F22981+NCI-C+CE3+Intergroup+Study.&rft.au=Lamers%2C+Leida+M%3BStupp%2C+Roger%3Bvan+den+Bent%2C+Martin+J%3BAl%2C+Maiwenn+J%3BGorlia%2C+Thierry%3BWasserfallen%2C+Jean-Blaise%3BMittmann%2C+Nicole%3BJin+Seung%2C+Soo%3BCrott%2C+Ralph%3BUyl-de+Groot%2C+Carin+A%3BEORTC+26981%2F22981+NCI-C+CE3+Intergroup+Study&rft.aulast=Lamers&rft.aufirst=Leida&rft.date=2008-03-15&rft.volume=112&rft.issue=6&rft.spage=1337&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.23297 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-08 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.23297 ER - TY - JOUR T1 - A stromal gene signature associated with inflammatory breast cancer. AN - 70242847; 17999412 AB - The factors that determine whether a breast carcinoma will develop into inflammatory breast cancer (IBC) remain poorly understood. Recent evidence indicates that the tumor stroma influences cancer phenotypes. We tested the hypotheses that the gene expression signature of the tumor stroma is a distinctive feature of IBC. We used laser capture microdissection to obtain enriched populations of tumor epithelial cells and adjacent stromal cells from 15 patients with IBC and 35 patients with invasive, noninflammatory breast cancer (non-IBC). Their mRNA expression profiles were assessed using Affymetrix GeneChips. In addition, a previously established classifier for IBC was evaluated for the resulting data sets. The gene expression profile of the tumor stroma distinguished IBC from non-IBC, and a previously established IBC prediction signature performed better in classifying IBC using the gene expression profile of the tumor stroma than it did using the profile of the tumor epithelium. In a pathway analysis, the genes differentially expressed between IBC and non-IBC tumors clustered in distinct pathways. We identified multiple pathways related to the endoplasmic stress response that could be functionally significant in IBC. Our findings suggest that the gene expression in the tumor stroma may play a role in determining the IBC phenotype. (c) 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Boersma, Brenda J AU - Reimers, Mark AU - Yi, Ming AU - Ludwig, Joseph A AU - Luke, Brian T AU - Stephens, Robert M AU - Yfantis, Harry G AU - Lee, Dong H AU - Weinstein, John N AU - Ambs, Stefan AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA. Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 1324 EP - 1332 VL - 122 IS - 6 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Immunohistochemistry KW - Female KW - Breast Neoplasms -- genetics KW - Gene Expression Profiling KW - Breast Neoplasms -- pathology KW - Inflammation -- genetics KW - Stromal Cells -- metabolism KW - Inflammation -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70242847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=A+stromal+gene+signature+associated+with+inflammatory+breast+cancer.&rft.au=Boersma%2C+Brenda+J%3BReimers%2C+Mark%3BYi%2C+Ming%3BLudwig%2C+Joseph+A%3BLuke%2C+Brian+T%3BStephens%2C+Robert+M%3BYfantis%2C+Harry+G%3BLee%2C+Dong+H%3BWeinstein%2C+John+N%3BAmbs%2C+Stefan&rft.aulast=Boersma&rft.aufirst=Brenda&rft.date=2008-03-15&rft.volume=122&rft.issue=6&rft.spage=1324&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-01 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Extracellular matrix and HIF-1 signaling: the role of prolidase. AN - 70239409; 17999410 AB - Hypoxia-inducible factor-1 (HIF-1) plays an important role in stress-responsive gene expression. Although primarily sensitive to hypoxia, HIF-1 signaling can be regulated by a number of stress factors including metabolic stress, growth factors and molecules present in the extracellular matrix (ECM). Degradation of ECM by metalloproteinases (MMP) is important for tumor progression, invasion and metastasis. ECM is predominantly collagen, and the imino acids (Pro and HyPro) comprise 25% of collagen residues. The final step in collagen degradation is catalyzed by prolidase, the obligate peptidase for imidodipeptides with Pro and HyPro in the carboxyl terminus. Defective wound healing in patients with inherited prolidase deficiency is associated with histologic features of angiopathy suggesting that prolidase may play a role in angiogenesis. Because HIF-1 alpha is central to angiogenesis, we considered that prolidase may modulate this pathway. To test this hypothesis, we made expression constructs of human prolidase and obtained stable transfectants in colorectal cancer cells (RKO). Overexpression of prolidase resulted in increased nuclear hypoxia inducible factor (HIF-1 alpha) levels and elevated expression of HIF-1-dependent gene products, vascular endothelial growth factor (VEGF) and glucose transporter-1 (Glut-1). The activation of HIF-1-dependent transcription was shown by prolidase-dependent activation of hypoxia response element (HRE)-luciferase expression. We used an oxygen-dependent degradation domain (ODD)-luciferase reporter construct as a surrogate for HIF-1 alpha as an in situ prolyl-hydroxylase assay. Since this reporter is degraded by VHL-dependent mechanisms, the increased levels of luciferase observed with prolidase expression reflected the decreased HIF-1 alpha prolyl hydroxylase activity. Additionally, the differential expression of prolidase in 2 breast cancer cell lines showed prolidase-dependent differences in HIF-1 alpha levels. These findings show that metabolism of imidodipeptides by prolidase plays a previously unrecognized role in angiogenic signaling. (c) 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Surazynski, Arkadiusz AU - Donald, Steven P AU - Cooper, Sandra K AU - Whiteside, Martin A AU - Salnikow, Konstantin AU - Liu, Yongmin AU - Phang, James M AD - Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 1435 EP - 1440 VL - 122 IS - 6 KW - HIF1A protein, human KW - 0 KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Dipeptidases KW - EC 3.4.13.- KW - proline dipeptidase KW - EC 3.4.13.9 KW - Index Medicus KW - Blotting, Western KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Cell Line, Tumor KW - Hydrolysis KW - Extracellular Matrix -- metabolism KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Signal Transduction KW - Dipeptidases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70239409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Extracellular+matrix+and+HIF-1+signaling%3A+the+role+of+prolidase.&rft.au=Surazynski%2C+Arkadiusz%3BDonald%2C+Steven+P%3BCooper%2C+Sandra+K%3BWhiteside%2C+Martin+A%3BSalnikow%2C+Konstantin%3BLiu%2C+Yongmin%3BPhang%2C+James+M&rft.aulast=Surazynski&rft.aufirst=Arkadiusz&rft.date=2008-03-15&rft.volume=122&rft.issue=6&rft.spage=1435&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-01 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease. AN - 69113018; 18279073 AB - Intravenous ganciclovir administered for 6 weeks improves hearing outcomes in infants with symptomatic congenital cytomegalovirus (CMV) disease involving the central nervous system. Twenty-four subjects received antiviral therapy for 6 weeks. Serial pharmacokinetic assessments were performed after administration of valganciclovir oral solution and of intravenous ganciclovir. On the basis of a previous pharmacokinetic study of the use of intravenous ganciclovir in this population, a target AUC12 (area under the concentration-time curve over a 12-h period) of 27 mg x h/L was defined. The median dose of oral valganciclovir administered in the present trial was 16 mg/kg, which produced a geometric mean AUC12 of 27.4 mg x h/L. The bioavailability of valganciclovir was 41.1%. Of the 18 subjects who had detectable CMV in whole blood at baseline or during therapy, 11 had or =4 log viral DNA copies/mL at baseline; subjects who started the study with the higher viral burden experienced greater decreases in viral load but did not clear virus during the 42-day course of therapy. Neutropenia of grade 3 or 4 developed in 38% of subjects. In neonates with symptomatic congenital CMV disease, valganciclovir oral solution provides plasma concentrations of ganciclovir comparable to those achieved with administration of intravenous ganciclovir. The results of the present study cannot be extrapolated to extemporaneously compounded liquid formulations of valganciclovir. JF - The Journal of infectious diseases AU - Kimberlin, David W AU - Acosta, Edward P AU - Sánchez, Pablo J AU - Sood, Sunil AU - Agrawal, Vish AU - Homans, James AU - Jacobs, Richard F AU - Lang, David AU - Romero, Jose R AU - Griffin, Jill AU - Cloud, Gretchen A AU - Lakeman, Fred D AU - Whitley, Richard J AU - National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA. dkimberlin@peds.uab.edu ; National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 836 EP - 845 VL - 197 IS - 6 SN - 0022-1899, 0022-1899 KW - valganciclovir KW - GCU97FKN3R KW - Ganciclovir KW - P9G3CKZ4P5 KW - Abridged Index Medicus KW - Index Medicus KW - Viral Load KW - Administration, Oral KW - Drug Administration Schedule KW - Area Under Curve KW - Humans KW - Infant, Newborn KW - Male KW - Female KW - Cytomegalovirus Infections -- drug therapy KW - Ganciclovir -- pharmacokinetics KW - Cytomegalovirus Infections -- congenital KW - Cytomegalovirus Infections -- blood KW - Ganciclovir -- adverse effects KW - Cytomegalovirus -- isolation & purification KW - Cytomegalovirus Infections -- virology KW - Ganciclovir -- analogs & derivatives KW - Ganciclovir -- pharmacology KW - Ganciclovir -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69113018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Pharmacokinetic+and+pharmacodynamic+assessment+of+oral+valganciclovir+in+the+treatment+of+symptomatic+congenital+cytomegalovirus+disease.&rft.au=Kimberlin%2C+David+W%3BAcosta%2C+Edward+P%3BS%C3%A1nchez%2C+Pablo+J%3BSood%2C+Sunil%3BAgrawal%2C+Vish%3BHomans%2C+James%3BJacobs%2C+Richard+F%3BLang%2C+David%3BRomero%2C+Jose+R%3BGriffin%2C+Jill%3BCloud%2C+Gretchen+A%3BLakeman%2C+Fred+D%3BWhitley%2C+Richard+J%3BNational+Institute+of+Allergy+and+Infectious+Diseases+Collaborative+Antiviral+Study+Group&rft.aulast=Kimberlin&rft.aufirst=David&rft.date=2008-03-15&rft.volume=197&rft.issue=6&rft.spage=836&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F528376 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/528376 ER - TY - JOUR T1 - Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody. AN - 69112077; 18271743 AB - We have previously identified neutralizing human monoclonal antibodies against Nipah virus (NiV) and Hendra virus (HeV) by panning a large nonimmune antibody library against a soluble form of the HeV attachment-envelope glycoprotein G (sG HeV). One of these antibodies, m102, which exhibited the highest level of cross-reactive neutralization of both NiV and HeV G, was affinity maturated by light-chain shuffling combined with random mutagenesis of its heavy-chain variable domain and panning against sGHeV. One of the selected antibody Fab clones, m102.4, had affinity of binding to sGHeV that was equal to or higher than that of the other Fabs; it was converted to IgG1 and tested against infectious NiV and HeV. It exhibited exceptionally potent and cross-reactive inhibitory activity with 50% inhibitory concentrations below 0.04 and 0.6 microg/mL, respectively. The virus-neutralizing activity correlated with the binding affinity of the antibody to sG HeV and sG NiV. m102.4 bound a soluble form of NiV G (sG NiV) better than it bound sG HeV, and it neutralized NiV better than HeV, despite being originally selected against sG HeV. These results suggest that m102.4 has potential as a therapeutic agent for the treatment of diseases caused by henipaviruses. It could be also used for prophylaxis and diagnosis, and as a research reagent. JF - The Journal of infectious diseases AU - Zhu, Zhongyu AU - Bossart, Katharine N AU - Bishop, Kimberly A AU - Crameri, Gary AU - Dimitrov, Antony S AU - McEachern, Jennifer A AU - Feng, Yang AU - Middleton, Deborah AU - Wang, Lin-Fa AU - Broder, Christopher C AU - Dimitrov, Dimiter S AD - Protein Interactions Group, Center for Cancer Research Nanobiology Program, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA. zhongyuzhu@ncifcrf.gov Y1 - 2008/03/15/ PY - 2008 DA - 2008 Mar 15 SP - 846 EP - 853 VL - 197 IS - 6 SN - 0022-1899, 0022-1899 KW - Antibodies, Monoclonal KW - 0 KW - Epitopes KW - Immunoglobulin Fragments KW - Immunoglobulin G KW - Viral Envelope Proteins KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Glioblastoma KW - HeLa Cells KW - Humans KW - Cell Line, Tumor KW - Immunoglobulin G -- immunology KW - Cross Reactions KW - Antibody Specificity KW - Viral Envelope Proteins -- immunology KW - Half-Life KW - Cercopithecus aethiops KW - Neutralization Tests KW - Vero Cells KW - Epitopes -- immunology KW - Immunoglobulin Fragments -- immunology KW - Binding Sites, Antibody KW - Henipavirus Infections -- virology KW - Antibodies, Monoclonal -- pharmacokinetics KW - Hendra Virus -- immunology KW - Nipah Virus -- physiology KW - Henipavirus Infections -- immunology KW - Nipah Virus -- immunology KW - Antibodies, Monoclonal -- pharmacology KW - Hendra Virus -- physiology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69112077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Exceptionally+potent+cross-reactive+neutralization+of+Nipah+and+Hendra+viruses+by+a+human+monoclonal+antibody.&rft.au=Zhu%2C+Zhongyu%3BBossart%2C+Katharine+N%3BBishop%2C+Kimberly+A%3BCrameri%2C+Gary%3BDimitrov%2C+Antony+S%3BMcEachern%2C+Jennifer+A%3BFeng%2C+Yang%3BMiddleton%2C+Deborah%3BWang%2C+Lin-Fa%3BBroder%2C+Christopher+C%3BDimitrov%2C+Dimiter+S&rft.aulast=Zhu&rft.aufirst=Zhongyu&rft.date=2008-03-15&rft.volume=197&rft.issue=6&rft.spage=846&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F528801 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/528801 ER - TY - JOUR T1 - Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. AN - 70394573; 18276852 AB - Alcohol dependence is a major public health challenge in need of new treatments. As alcoholism evolves, stress systems in the brain play an increasing role in motivating continued alcohol use and relapse. We investigated the role of the neurokinin 1 receptor (NK1R), a mediator of behavioral stress responses, in alcohol dependence and treatment. In preclinical studies, mice genetically deficient in NK1R showed a marked decrease in voluntary alcohol consumption and had an increased sensitivity to the sedative effects of alcohol. In a randomized controlled experimental study, we treated recently detoxified alcoholic inpatients with an NK1R antagonist (LY686017; n = 25) or placebo (n = 25). LY686017 suppressed spontaneous alcohol cravings, improved overall well-being, blunted cravings induced by a challenge procedure, and attenuated concomitant cortisol responses. Brain functional magnetic resonance imaging responses to affective stimuli likewise suggested beneficial LY686017 effects. Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism. JF - Science (New York, N.Y.) AU - George, David T AU - Gilman, Jodi AU - Hersh, Jacqueline AU - Thorsell, Annika AU - Herion, David AU - Geyer, Christopher AU - Peng, Xiaomei AU - Kielbasa, William AU - Rawlings, Robert AU - Brandt, John E AU - Gehlert, Donald R AU - Tauscher, Johannes T AU - Hunt, Stephen P AU - Hommer, Daniel AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 SP - 1536 EP - 1539 VL - 319 IS - 5869 KW - LY686017 KW - 0 KW - Neurokinin-1 Receptor Antagonists KW - Pyridines KW - Receptors, Neurokinin-1 KW - Triazoles KW - Ethanol KW - 3K9958V90M KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Humans KW - Ethanol -- administration & dosage KW - Aged KW - Mice KW - Behavior, Addictive -- drug therapy KW - Brain -- physiology KW - Emotions -- drug effects KW - Hydrocortisone -- blood KW - Adult KW - Mice, Inbred C57BL KW - Middle Aged KW - Male KW - Female KW - Receptors, Neurokinin-1 -- physiology KW - Receptors, Neurokinin-1 -- deficiency KW - Alcohol Drinking -- drug therapy KW - Pyridines -- administration & dosage KW - Receptors, Neurokinin-1 -- genetics KW - Pyridines -- therapeutic use KW - Triazoles -- therapeutic use KW - Triazoles -- pharmacology KW - Pyridines -- pharmacology KW - Alcoholism -- drug therapy KW - Triazoles -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70394573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Neurokinin+1+receptor+antagonism+as+a+possible+therapy+for+alcoholism.&rft.au=George%2C+David+T%3BGilman%2C+Jodi%3BHersh%2C+Jacqueline%3BThorsell%2C+Annika%3BHerion%2C+David%3BGeyer%2C+Christopher%3BPeng%2C+Xiaomei%3BKielbasa%2C+William%3BRawlings%2C+Robert%3BBrandt%2C+John+E%3BGehlert%2C+Donald+R%3BTauscher%2C+Johannes+T%3BHunt%2C+Stephen+P%3BHommer%2C+Daniel%3BHeilig%2C+Markus&rft.aulast=George&rft.aufirst=David&rft.date=2008-03-14&rft.volume=319&rft.issue=5869&rft.spage=1536&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/10.1126%2Fscience.1153813 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-26 N1 - Date created - 2008-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1126/science.1153813 ER - TY - CPAPER T1 - Eosinophils from Patients with FIP1L1/PDGFRA-Positive Chronic Eosinophilic Leukemia Show Increased Activation and Granule Protein Turnover T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40730929; 4763670 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Ogbogu, P U AU - Brown, M AU - Nutman, T B AU - Klion, A D Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Eosinophilic leukemia KW - Protein turnover KW - Cell activation KW - Leukocytes (eosinophilic) KW - Granules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40730929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Eosinophils+from+Patients+with+FIP1L1%2FPDGFRA-Positive+Chronic+Eosinophilic+Leukemia+Show+Increased+Activation+and+Granule+Protein+Turnover&rft.au=Ogbogu%2C+P+U%3BBrown%2C+M%3BNutman%2C+T+B%3BKlion%2C+A+D&rft.aulast=Ogbogu&rft.aufirst=P&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Demonstration that IgE Influences HIV Coreceptor Usage and Viral Phenotype during Ontogeny of Human Mast Cells T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40724180; 4763416 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Kirshenbaum, A S AU - Hair, G A AU - Ansari, A A AU - Secor, W E AU - Gilfillan, A M AU - Metcalfe, D D AU - Sundstrom, J B Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Human immunodeficiency virus KW - Mast cells KW - Ontogeny KW - Immunoglobulin E KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40724180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Demonstration+that+IgE+Influences+HIV+Coreceptor+Usage+and+Viral+Phenotype+during+Ontogeny+of+Human+Mast+Cells&rft.au=Kirshenbaum%2C+A+S%3BHair%2C+G+A%3BAnsari%2C+A+A%3BSecor%2C+W+E%3BGilfillan%2C+A+M%3BMetcalfe%2C+D+D%3BSundstrom%2C+J+B&rft.aulast=Kirshenbaum&rft.aufirst=A&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Influenza Specific T-Cell Response in Allergic and Healthy Controls T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40723325; 4763925 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Kim, N AU - Foster, B AU - Prussin, C Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Influenza KW - Hypersensitivity KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40723325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Detection+of+Influenza+Specific+T-Cell+Response+in+Allergic+and+Healthy+Controls&rft.au=Kim%2C+N%3BFoster%2C+B%3BPrussin%2C+C&rft.aulast=Kim&rft.aufirst=N&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anti-IgE Therapy Does Not have Immunomodulatory Activity on Allergen Specific T Cells T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40721986; 4763898 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Prussin, C AU - Foster, B AU - Foroughi, S Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Allergens KW - Lymphocytes T KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Anti-IgE+Therapy+Does+Not+have+Immunomodulatory+Activity+on+Allergen+Specific+T+Cells&rft.au=Prussin%2C+C%3BFoster%2C+B%3BForoughi%2C+S&rft.aulast=Prussin&rft.aufirst=C&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD4+ T Lymphocyte Dysregulation in Food Allergy and Eosinophilic Gastroenteritis (EG) T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40721836; 4763857 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Lee, J AU - Foster, B AU - Prussin, C Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Gastroenteritis KW - Lymphocytes KW - Food hypersensitivity KW - Lymphocytes T KW - CD4 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=CD4%2B+T+Lymphocyte+Dysregulation+in+Food+Allergy+and+Eosinophilic+Gastroenteritis+%28EG%29&rft.au=Lee%2C+J%3BFoster%2C+B%3BPrussin%2C+C&rft.aulast=Lee&rft.aufirst=J&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship of Active Asthma and Current Dog and Cat Allergen Exposure in Beds T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40721736; 4763815 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Sever, M L AU - Salo, P M AU - Cohn, R D AU - Zeldin, D C Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Respiratory diseases KW - Asthma KW - Allergens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Relationship+of+Active+Asthma+and+Current+Dog+and+Cat+Allergen+Exposure+in+Beds&rft.au=Sever%2C+M+L%3BSalo%2C+P+M%3BCohn%2C+R+D%3BZeldin%2C+D+C&rft.aulast=Sever&rft.aufirst=M&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exposure to Mouse Allergen in US Homes is Associated with Asthma Symptoms T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40721127; 4764229 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Salo, P M AU - Cohn, R D AU - Zeldin, D C Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Respiratory diseases KW - Asthma KW - Allergens KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Exposure+to+Mouse+Allergen+in+US+Homes+is+Associated+with+Asthma+Symptoms&rft.au=Salo%2C+P+M%3BCohn%2C+R+D%3BZeldin%2C+D+C&rft.aulast=Salo&rft.aufirst=P&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Suppressive Function of Human T Regulatory Cells is Contact-mediated and Requires Interleukin-2 T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40720920; 4764208 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Tran, D Q AU - Glass, D D AU - Shevach, E M Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Interleukin 2 KW - Lymphocytes T KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=The+Suppressive+Function+of+Human+T+Regulatory+Cells+is+Contact-mediated+and+Requires+Interleukin-2&rft.au=Tran%2C+D+Q%3BGlass%2C+D+D%3BShevach%2C+E+M&rft.aulast=Tran&rft.aufirst=D&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mast Cell Degranulation Inhibits Th1 and Promotes Th2 Responses T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40720780; 4763893 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Meyer-Manlapat, A K AU - Segal, D M Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Lymphocytes T KW - Helper cells KW - Mast cells KW - Degranulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Mast+Cell+Degranulation+Inhibits+Th1+and+Promotes+Th2+Responses&rft.au=Meyer-Manlapat%2C+A+K%3BSegal%2C+D+M&rft.aulast=Meyer-Manlapat&rft.aufirst=A&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Superoxide Production by Mast Cells T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40720719; 4763880 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Swindle, E J AU - DeLeo, F R AU - Metcalfe, D D Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Mast cells KW - Superoxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Intracellular+Superoxide+Production+by+Mast+Cells&rft.au=Swindle%2C+E+J%3BDeLeo%2C+F+R%3BMetcalfe%2C+D+D&rft.aulast=Swindle&rft.aufirst=E&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acquired Activating NRAS Mutations Associated with Aggressive Systemic Mastocytosis T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40720209; 4763875 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Wilson, T M AU - Wu, Y. AU - Fu, W. AU - Bai, Y AU - Noel, P AU - Maric, I AU - Robyn, J AU - Metcalfe, D D Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Mutation KW - Mastocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Acquired+Activating+NRAS+Mutations+Associated+with+Aggressive+Systemic+Mastocytosis&rft.au=Wilson%2C+T+M%3BWu%2C+Y.%3BFu%2C+W.%3BBai%2C+Y%3BNoel%2C+P%3BMaric%2C+I%3BRobyn%2C+J%3BMetcalfe%2C+D+D&rft.aulast=Wilson&rft.aufirst=T&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serum Tryptase Levels in Atopic and Non-Atopic Children T2 - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AN - 40717111; 4763891 JF - 2008 Annual Meeting of the American Academy of Allergy Asthma and Immunology AU - Uzzaman, A AU - Hu, Z. AU - Brittain, E AU - Carter, M C AU - Metcalfe, D D AU - Komarow, H D Y1 - 2008/03/14/ PY - 2008 DA - 2008 Mar 14 KW - Children KW - Tryptase KW - Atopy KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.atitle=Serum+Tryptase+Levels+in+Atopic+and+Non-Atopic+Children&rft.au=Uzzaman%2C+A%3BHu%2C+Z.%3BBrittain%2C+E%3BCarter%2C+M+C%3BMetcalfe%2C+D+D%3BKomarow%2C+H+D&rft.aulast=Uzzaman&rft.aufirst=A&rft.date=2008-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B4F6F2478%2DD5DF%2D49CD% 2D8D8E%2DDF42F8952832%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cerebrospinal fluid to brain transport of manganese in a non-human primate revealed by MRI. AN - 70332519; 18243167 AB - Manganese overexposure in non-human primates and humans causes a neurodegenerative disorder called manganism thought to be related to an accumulation of the metal in the basal ganglia. Here, we assess changes in the concentration of manganese in regions of the brain of a non-human primate (the common marmoset, Callithrix jacchus) following four systemic injections of 30 mg/kg MnCl2 H2O in the tail vein using T1-weighted magnetic resonance imaging (MRI) and compare these to changes in the rat following the same exposure route and dose. The doses were spaced 48 h apart and we imaged the animals 48 h after the final dose. We find that marmosets have significantly larger T1-weighted image enhancements in regions of the brain compared to rats, notably in the basal ganglia and the visual cortex. To confirm this difference across species reflects actual differences in manganese concentrations and not variations in the MRI properties of manganese, we measured the longitudinal relaxivity of manganese (chi1) in the in vivo brain and found no significant species' difference. The high manganese uptake in the marmoset basal ganglia and visual cortex can be explained by CSF-brain transport from the large lateral ventricles and we confirm this route of uptake with time-course MRI during a tail-vein infusion of manganese. There is also high uptake in the substructures of the hippocampus that are adjacent to the ventricles. The large manganese accumulation in these structures on overexposure may be common to all primates, including humans. JF - Brain research AU - Bock, Nicholas A AU - Paiva, Fernando F AU - Nascimento, George C AU - Newman, John D AU - Silva, Afonso C AD - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1065, USA. bockn@mail.nih.gov Y1 - 2008/03/10/ PY - 2008 DA - 2008 Mar 10 SP - 160 EP - 170 VL - 1198 SN - 0006-8993, 0006-8993 KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Animals KW - Rodentia -- metabolism KW - Drug Administration Schedule KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Brain Chemistry -- drug effects KW - Lateral Ventricles -- drug effects KW - Lateral Ventricles -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Brain Mapping KW - Magnetic Resonance Imaging -- methods KW - Cerebrospinal Fluid -- metabolism KW - Cerebrospinal Fluid -- drug effects KW - Species Specificity KW - Male KW - Female KW - Brain Chemistry -- physiology KW - Manganese -- cerebrospinal fluid KW - Callithrix -- metabolism KW - Brain -- drug effects KW - Brain -- anatomy & histology KW - Manganese Poisoning -- physiopathology KW - Callithrix -- anatomy & histology KW - Brain -- metabolism KW - Manganese -- pharmacokinetics KW - Manganese Poisoning -- metabolism KW - Manganese -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70332519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Cerebrospinal+fluid+to+brain+transport+of+manganese+in+a+non-human+primate+revealed+by+MRI.&rft.au=Bock%2C+Nicholas+A%3BPaiva%2C+Fernando+F%3BNascimento%2C+George+C%3BNewman%2C+John+D%3BSilva%2C+Afonso+C&rft.aulast=Bock&rft.aufirst=Nicholas&rft.date=2008-03-10&rft.volume=1198&rft.issue=&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2007.12.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-02 N1 - Date created - 2008-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroimage. 2002 Jun;16(2):441-8 [12030829] Neuroradiology. 2007 Sep;49(9):715-20 [17624522] J Neurosci Methods. 2002 Oct 30;120(2):203-9 [12385770] Brain Res Brain Res Rev. 2003 Jan;41(1):79-87 [12505649] Neurotoxicology. 2003 Jan;24(1):3-13 [12564377] Magn Reson Med. 2003 Jul;50(1):33-9 [12815676] Environ Res. 2003 Oct;93(2):149-57 [12963399] Neurotoxicology. 2003 Dec;24(6):909-15 [14637385] Ann N Y Acad Sci. 2004 Mar;1012:115-28 [15105259] Neuroimage. 2004 Jul;22(3):1046-59 [15219577] Curr Top Cell Regul. 1984;24:153-69 [6149889] Invest Radiol. 1984 Sep-Oct;19(5):399-407 [6511248] Brain Res. 1990 Mar 5;510(2):289-95 [2158851] J Neurochem. 1991 Sep;57(3):948-54 [1861159] Toxicol Appl Pharmacol. 1974 Sep;29(3):458-68 [4283708] J Neurochem. 1993 Aug;61(2):509-17 [7687654] Brain Res. 1994 Sep 19;657(1-2):124-32 [7820609] Neurology. 1995 Jun;45(6):1199-204 [7783889] Lancet. 1995 Jul 29;346(8970):270-4 [7630246] Brain Res. 1995 Oct 9;695(1):53-8 [8574647] Pharmacol Toxicol. 1995 Jul;77(1):23-31 [8532608] Neurology. 1996 Feb;46(2):492-8 [8614520] Pharmacol Toxicol. 1996 Dec;79(6):347-56 [9000264] Magn Reson Med. 1997 Sep;38(3):378-88 [9339438] Toxicol Appl Pharmacol. 1999 Apr 15;156(2):119-28 [10198277] Neurotoxicology. 1999 Apr-Jun;20(2-3):227-38 [10385886] Magn Reson Med. 2005 Mar;53(3):666-74 [15723397] Magn Reson Med. 2005 Mar;53(3):640-8 [15723400] NMR Biomed. 2004 Dec;17(8):544-53 [15617053] Crit Rev Toxicol. 2005 Jan;35(1):1-32 [15742901] Toxicol Appl Pharmacol. 2006 Mar 1;211(2):166-74 [16112697] Magn Reson Med. 2006 Mar;55(3):604-11 [16470592] Magn Reson Imaging. 2006 May;24(4):349-58 [16677940] Neurotoxicology. 2006 May;27(3):304-10 [16219356] Neurotoxicology. 2006 May;27(3):340-6 [16325915] Neurotoxicology. 2006 May;27(3):315-26 [16343629] Toxicol Sci. 2006 Jul;92(1):201-10 [16624849] Toxicol Sci. 2006 Jul;92(1):219-27 [16638924] Eur J Neurol. 2006 Oct;13(10):1139-41 [16987168] Toxicol Sci. 2006 Dec;94(2):351-8 [16968886] FASEB J. 2007 Jan;21(1):223-30 [17116743] Pharmacol Ther. 2007 Feb;113(2):369-77 [17084903] Neurotoxicology. 2007 Jan;28(1):126-35 [16978697] J Toxicol Environ Health A. 2007 Apr 1;70(7):594-605 [17365613] Toxicol Appl Pharmacol. 2007 Jun 1;221(2):131-47 [17466353] Neuron. 2002 May 30;34(5):685-700 [12062017] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2007.12.065 ER - TY - JOUR T1 - Medicine. Moving toward transparency of clinical trials. AN - 70370251; 18323436 JF - Science (New York, N.Y.) AU - Zarin, Deborah A AU - Tse, Tony AD - National Library of Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20894, USA. dzarin@mail.nih.gov Y1 - 2008/03/07/ PY - 2008 DA - 2008 Mar 07 SP - 1340 EP - 1342 VL - 319 IS - 5868 KW - Index Medicus KW - United States KW - Intellectual Property KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Product Surveillance, Postmarketing KW - Databases, Factual KW - Publishing KW - Public Policy KW - Disclosure KW - Registries KW - Access to Information KW - Clinical Trials as Topic -- standards KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Clinical Trials as Topic -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70370251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Medicine.+Moving+toward+transparency+of+clinical+trials.&rft.au=Zarin%2C+Deborah+A%3BTse%2C+Tony&rft.aulast=Zarin&rft.aufirst=Deborah&rft.date=2008-03-07&rft.volume=319&rft.issue=5868&rft.spage=1340&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/10.1126%2Fscience.1153632 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-21 N1 - Date created - 2008-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2004 Sep 15;292(11):1359-62 [15355937] JAMA. 2004 Sep 15;292(11):1363-4 [15355936] Lancet. 1991 Apr 13;337(8746):867-72 [1672966] J R Soc Med. 1995;88 Suppl 24:12-6 [7776320] JAMA. 2004 Dec 1;292(21):2622-31 [15572720] Circulation. 2005 Sep 27;112(13):2040-2 [16172264] N Engl J Med. 2005 Dec 29;353(26):2779-87 [16382064] Science. 2006 Jan 13;311(5758):180-1 [16410509] BMJ. 2006 Mar 25;332(7543):677-8 [16554332] Lancet. 2006 May 20;367(9523):1631-3 [16714166] N Engl J Med. 2006 Nov 23;355(21):2169-71 [17124012] BMJ. 2007 Jan 20;334(7585):120-3 [17235089] N Engl J Med. 2007 Apr 19;356(16):1601-4 [17442902] JAMA. 2007 May 16;297(19):2112-20 [17507347] N Engl J Med. 2007 Jun 14;356(24):2457-71 [17517853] N Engl J Med. 2007 Jun 14;356(24):2522-4 [17517854] N Engl J Med. 2007 Jun 28;356(26):2734-6 [17548427] Nat Rev Drug Discov. 2007 Jul;6(7):532-9 [17491596] Arch Intern Med. 2007 Aug 13-27;167(15):1576-80 [17698679] N Engl J Med. 2007 Aug 30;357(9):844-6 [17687124] N Engl J Med. 2007 Oct 25;357(17):1756-7 [17914035] Nat Clin Pract Neurol. 2007 Nov;3(11):590-1 [17876349] N Engl J Med. 2007 Nov 29;357(22):2219-21 [18046025] N Engl J Med. 2008 Jan 17;358(3):252-60 [18199864] N Engl J Med. 2006 Nov 23;355(21):2171-3 [17124013] J Clin Oncol. 1986 Oct;4(10):1529-41 [3760920] JAMA. 2002 Jul 17;288(3):363-5 [12117402] Ann Intern Med. 2002 Aug 20;137(4):290 [12186521] Science. 2004 Feb 6;303(5659):745 [14764841] Comment In: Science. 2008 Oct 3;322(5898):44-6 [18832629] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1126/science.1153632 ER - TY - JOUR T1 - Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition. AN - 70368791; 18322101 AB - Lithium and valproic acid (VPA) are two primary drugs used to treat bipolar mood disorder and have frequently been used in combination to treat bipolar patients resistant to monotherapy with either drug. Lithium, a glycogen synthase kinase-3 (GSK-3) inhibitor, and VPA, a histone deacetylase (HDAC) inhibitor, have neuroprotective effects. The present study was undertaken to demonstrate synergistic neuroprotective effects when both drugs were coadministered. Pretreatment of aging cerebellar granule cells with lithium or VPA alone provided little or no neuroprotection against glutamate-induced cell death. However, copresence of both drugs resulted in complete blockade of glutamate excitotoxicity. Combined treatment with lithium and VPA potentiated serine phosphorylation of GSK-3 alpha and beta isoforms and inhibition of GSK-3 enzyme activity. Transfection with GSK-3alpha small interfering RNA (siRNA) and/or GSK-3beta siRNA mimicked the ability of lithium to induce synergistic protection with VPA. HDAC1 siRNA or other HDAC inhibitors (phenylbutyrate, sodium butyrate or trichostatin A) also caused synergistic neuroprotection together with lithium. Moreover, combination of lithium and HDAC inhibitors potentiated beta-catenin-dependent, Lef/Tcf-mediated transcriptional activity. An additive increase in GSK-3 serine phosphorylation was also observed in mice chronically treated with lithium and VPA. Together, for the first time, our results demonstrate synergistic neuroprotective effects of lithium and HDAC inhibitors and suggest that GSK-3 inhibition is a likely molecular target for the synergistic neuroprotection. Our results may have implications for the combined use of lithium and VPA in treating bipolar disorder. Additionally, combined use of both drugs may be warranted for clinical trials to treat glutamate-related neurodegenerative diseases. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Leng, Yan AU - Liang, Min-Huei AU - Ren, Ming AU - Marinova, Zoya AU - Leeds, Peter AU - Chuang, De-Maw AD - Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1363, USA. Y1 - 2008/03/05/ PY - 2008 DA - 2008 Mar 05 SP - 2576 EP - 2588 VL - 28 IS - 10 KW - Enzyme Inhibitors KW - 0 KW - Histone Deacetylase Inhibitors KW - Neuroprotective Agents KW - Valproic Acid KW - 614OI1Z5WI KW - Lithium KW - 9FN79X2M3F KW - Glycogen Synthase Kinase 3 KW - EC 2.7.11.26 KW - Histone Deacetylases KW - EC 3.5.1.98 KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Histone Deacetylases -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Drug Synergism KW - Valproic Acid -- pharmacology KW - Neurons -- drug effects KW - Neurons -- enzymology KW - Glycogen Synthase Kinase 3 -- metabolism KW - Glycogen Synthase Kinase 3 -- antagonists & inhibitors KW - Neuroprotective Agents -- pharmacology KW - Lithium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70368791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Synergistic+neuroprotective+effects+of+lithium+and+valproic+acid+or+other+histone+deacetylase+inhibitors+in+neurons%3A+roles+of+glycogen+synthase+kinase-3+inhibition.&rft.au=Leng%2C+Yan%3BLiang%2C+Min-Huei%3BRen%2C+Ming%3BMarinova%2C+Zoya%3BLeeds%2C+Peter%3BChuang%2C+De-Maw&rft.aulast=Leng&rft.aufirst=Yan&rft.date=2008-03-05&rft.volume=28&rft.issue=10&rft.spage=2576&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.5467-07.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-07 N1 - Date created - 2008-03-06 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1523/JNEUROSCI.5467-07.2008 ER - TY - CPAPER T1 - Hdac Inhibitor Vorinostat Induced Synergistic Antitumor Effect in Combination with 5-Fluorouracil or Raltitrexed in Human Cancer Cells by Modulating Thymidylate Synthase and P53 Expression T2 - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AN - 40973770; 4874433 JF - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AU - Budillon, Alfredo AU - Di Gennaro, Elena AU - Avallone, Antonio AU - Bruzzese, Francesca Y1 - 2008/03/05/ PY - 2008 DA - 2008 Mar 05 KW - Cancer KW - 5-Fluorouracil KW - Antitumor activity KW - P53 protein KW - Histone deacetylase KW - Thymidylate synthase KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40973770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.atitle=Hdac+Inhibitor+Vorinostat+Induced+Synergistic+Antitumor+Effect+in+Combination+with+5-Fluorouracil+or+Raltitrexed+in+Human+Cancer+Cells+by+Modulating+Thymidylate+Synthase+and+P53+Expression&rft.au=Budillon%2C+Alfredo%3BDi+Gennaro%2C+Elena%3BAvallone%2C+Antonio%3BBruzzese%2C+Francesca&rft.aulast=Budillon&rft.aufirst=Alfredo&rft.date=2008-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://iospress.metapress.com/content/p39v6085561v/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Fuzzy-Immune Approach Useful to Investigate Chromosomal Hightroughtput Data T2 - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AN - 40972751; 4874329 JF - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AU - Tommasi, Stefania AU - Menolascina, Filippo AU - Bevilacqua, Vitoantonio AU - Alves, Roberto AU - Mastronardi, Giuseppe AU - Paradiso, Angelo Y1 - 2008/03/05/ PY - 2008 DA - 2008 Mar 05 KW - Data processing KW - Chromosomes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40972751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.atitle=A+Fuzzy-Immune+Approach+Useful+to+Investigate+Chromosomal+Hightroughtput+Data&rft.au=Tommasi%2C+Stefania%3BMenolascina%2C+Filippo%3BBevilacqua%2C+Vitoantonio%3BAlves%2C+Roberto%3BMastronardi%2C+Giuseppe%3BParadiso%2C+Angelo&rft.aulast=Tommasi&rft.aufirst=Stefania&rft.date=2008-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://iospress.metapress.com/content/p39v6085561v/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acgh Analysis of 30 Male Breast Cancers (MBC) T2 - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AN - 40961159; 4874360 JF - 2008 Conference of the International Society for Cellular Oncology (ISCO 2008) AU - Mangia, Anita AU - Chiarappa, Patrizia AU - Tommasi, Stefania AU - Rossi, Elena AU - Menolascina, Filippo AU - Ottini, Laura AU - Mottolese, Marcella AU - Paradiso, Angelo Y1 - 2008/03/05/ PY - 2008 DA - 2008 Mar 05 KW - Breast cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40961159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.atitle=Acgh+Analysis+of+30+Male+Breast+Cancers+%28MBC%29&rft.au=Mangia%2C+Anita%3BChiarappa%2C+Patrizia%3BTommasi%2C+Stefania%3BRossi%2C+Elena%3BMenolascina%2C+Filippo%3BOttini%2C+Laura%3BMottolese%2C+Marcella%3BParadiso%2C+Angelo&rft.aulast=Mangia&rft.aufirst=Anita&rft.date=2008-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Conference+of+the+International+Society+for+Cellular+Oncology+%28ISCO+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://iospress.metapress.com/content/p39v6085561v/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-25 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy AN - 20548861; 8089256 AB - We demonstrate a role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. In particular, transient increased expression of Sirt1 is sufficient to stimulate basal rates of autophagy. In addition, we show that Sirt1 super(-/-) mouse embryonic fibroblasts do not fully activate autophagy under starved conditions. Reconstitution with wild-type but not a deacetylase-inactive mutant of Sirt1 restores autophagy in these cells. We further demonstrate that Sirt1 can form a molecular complex with several essential components of the autophagy machinery, including autophagy genes (Atg)5, Atg7, and Atg8. In vitro, Sirt1 can, in an NAD-dependent fashion, directly deacetylate these components. The absence of Sirt1 leads to markedly elevated acetylation of proteins known to be required for autophagy in both cultured cells and in embryonic and neonatal tissues. Finally, we show that Sirt1 super(-/-) mice partially resemble Atg5 super(-/-) mice, including the accumulation of damaged organelles, disruption of energy homeostasis, and early perinatal mortality. Furthermore, the in utero delivery of the metabolic substrate pyruvate extends the survival of Sirt1 super(-/-) pups. These results suggest that the Sirt1 deacetylase is an important in vivo regulator of autophagy and provide a link between sirtuin function and the overall cellular response to limited nutrients. JF - Proceedings of the National Academy of Sciences, USA AU - Lee, In Hye AU - Cao, Liu AU - Mostoslavsky, Raul AU - Lombard, David B AU - Liu, Jie AU - Bruns, Nicholas E AU - Tsokos, Maria AU - Alt, Frederick W AU - Finkel, Toren AD - Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/03/04/ PY - 2008 DA - 2008 Mar 04 SP - 3374 EP - 3379 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 9 SN - 0027-8424, 0027-8424 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20548861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=A+role+for+the+NAD-dependent+deacetylase+Sirt1+in+the+regulation+of+autophagy&rft.au=Lee%2C+In+Hye%3BCao%2C+Liu%3BMostoslavsky%2C+Raul%3BLombard%2C+David+B%3BLiu%2C+Jie%3BBruns%2C+Nicholas+E%3BTsokos%2C+Maria%3BAlt%2C+Frederick+W%3BFinkel%2C+Toren&rft.aulast=Lee&rft.aufirst=In&rft.date=2008-03-04&rft.volume=105&rft.issue=9&rft.spage=3374&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Theatre of the oppressed and environmental justice communities: a transformational therapy for the body politic. AN - 734184104; 18375623 AB - Community Environmental Forum Theatre at UTMB-NIEHS Center in Environmental Toxicology uses Augusto Boal's Theatre of the Oppressed (TO) to promote involvement of citizens, scientists, and health professionals in deconstructing toxic exposures, risk factors, and cumulative stressors that impact the well-being of communities. The TO process encourages collective empowerment of communities by disseminating information and elaborating support networks. TO also elicits transformation and growth on a personal level via a dramaturgical system that restores spontaneity through image-making and improvisation. An NIEHS Environmental Justice Project, Communities Organized against Asthma & Lead, illustrates this interplay of personal and collective change in Houston, Texas. JF - Journal of health psychology AU - Sullivan, John AU - Petronella, Sharon AU - Brooks, Edward AU - Murillo, Maria AU - Primeau, Loree AU - Ward, Jonathan AD - Sealy Center for Environmental Health & Medicine/NIEHS Center in Environmental Toxicology, 301 University Blvd, University of Texas Medical Branch, Galveston, TX 77555-1110, USA. josulliv@utmb.edu Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 166 EP - 179 VL - 13 IS - 2 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Lead Poisoning -- prevention & control KW - Cooperative Behavior KW - Humans KW - Power (Psychology) KW - Asthma -- prevention & control KW - Consumer Advocacy KW - Texas KW - Interdisciplinary Communication KW - Louisiana KW - Environment KW - Vulnerable Populations KW - Environmental Pollutants -- toxicity KW - Environmental Health KW - Politics KW - Psychodrama KW - Community Participation KW - Social Justice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734184104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+psychology&rft.atitle=Theatre+of+the+oppressed+and+environmental+justice+communities%3A+a+transformational+therapy+for+the+body+politic.&rft.au=Sullivan%2C+John%3BPetronella%2C+Sharon%3BBrooks%2C+Edward%3BMurillo%2C+Maria%3BPrimeau%2C+Loree%3BWard%2C+Jonathan&rft.aulast=Sullivan&rft.aufirst=John&rft.date=2008-03-01&rft.volume=13&rft.issue=2&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+psychology&rft.issn=1461-7277&rft_id=info:doi/10.1177%2F1359105307086710 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2008-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/1359105307086710 ER - TY - JOUR T1 - The role of surgical management in pediatric germ cell tumors (GCTs), NCI case series. AN - 734097710; 19847284 AB - To review the experience of a tertiary referral center in pediatric germ cell tumors (GCTs) in the last 8 years and to investigate the impact of surgery and site of disease on prognosis. We retrospectively analyzed the cases of pediatric germ cell tumors at National Cancer Institute over an 8 years period. Data concerning diagnosis, surgery and medical decisions were reviewed and analyzed for all patients. A total of 34 children with (GCTS) were found, with a mean age, at presentation, of 6.7 years and a follow-up period ranging from 3-52 months. One patient with benign GCT was excluded during analysis of the results. Among the 34 patients, there were 14 males and 20 females with mean age of 6.7 years (range: 9 months-15 years), with male to female ratio 1:1.4. All patients were symptomatic at presentation, most commonly with abdominal swelling (18 patients; 52.9%). Anatomic distribution of GCTs according to sex organ involvement was either gonadal in 21 patients (61.8%) or extragonadal in 13 patients (38.2%). All patients had surgery either in the form of curative resection or biopsy after formal exploration and evidence of irresectability. No significant surgical morbidity or mortality were encountered in our patients. Yolk sac tumor and malignant teratoma were the commonest histologic subtypes in our series. Metastatic disease was encountered in nine out of 33 patients (27.2%). Adjuvant chemotherapy was administered in 28 out of 33 patients (84.8%), following surgery, including all patients with extragonadal disease. Our patients were followed-up to 52 months. Twenty-two patients (66.7%) had no recurrence while two patients (6.1%) died from disease. Pelvic extragonadal site was the worst site regarding resectability. Complete surgical resection showed better disease free survival, while those with irresectable disease had comparable overall survival while none could be rendered disease free with chemotherapy. The initial surgical approach to malignant GCTs at all sites should be complete resection when possible; the morbidity of extensive surgical resection should be weighed carefully against the good tumor control with chemotherapy. Surgical staging does not preclude preservation of fertility, which should always be considered in this young age. The site of primary disease plays a role in the prognosis of pediatric germ cell tumors with the extragonadal pelvic tumors being the worst regarding resectability. Good tumor response can be achieved with surgery and chemotherapy even for advanced stage and metastatic disease. JF - Journal of the Egyptian National Cancer Institute AU - Fakhr, Ibrahim M Y AU - Khalil, El-Sayed Ashraf AU - El-Baradie, Tarek S AU - Shaalan, Mohamed A AU - Shalaby, Lobna M AU - Nassif, Shimaa L A AU - Farahat, Iman G AD - The Department of Surgical Oncology, National Cancer Institute (NCI), Cairo University. ibrahimfakhr@hotmail.com Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 70 EP - 79 VL - 20 IS - 1 SN - 1110-0362, 1110-0362 KW - Index Medicus KW - Infant KW - Neoplasm Staging KW - Lymphatic Metastasis KW - Humans KW - Retrospective Studies KW - Prognosis KW - Child KW - Adolescent KW - Male KW - Female KW - Chemotherapy, Adjuvant KW - Child, Preschool KW - Neoplasms, Germ Cell and Embryonal -- mortality KW - Neoplasms, Germ Cell and Embryonal -- pathology KW - Neoplasms, Germ Cell and Embryonal -- drug therapy KW - Neoplasms, Germ Cell and Embryonal -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734097710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=The+role+of+surgical+management+in+pediatric+germ+cell+tumors+%28GCTs%29%2C+NCI+case+series.&rft.au=Fakhr%2C+Ibrahim+M+Y%3BKhalil%2C+El-Sayed+Ashraf%3BEl-Baradie%2C+Tarek+S%3BShaalan%2C+Mohamed+A%3BShalaby%2C+Lobna+M%3BNassif%2C+Shimaa+L+A%3BFarahat%2C+Iman+G&rft.aulast=Fakhr&rft.aufirst=Ibrahim+M&rft.date=2008-03-01&rft.volume=20&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-05 N1 - Date created - 2009-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Filarial infections in travelers and immigrants. AN - 734025530; 18377816 AB - Filarial infections including loiasis, onchocerciasis, and lymphatic filariasis are important causes of morbidity in endemic populations worldwide, and they present a risk to travelers to endemic areas. Definitive diagnosis is complicated by overlap in the geographic distribution and clinical manifestations of the different filarial parasites, as well as similarities in their antigenic and nucleic acid composition. This has important implications for treatment, because the efficacies and toxicities of available antifilarial agents differ dramatically among filarial species. Recent advances, including the visualization of adult filarial worms in vivo by high-frequency ultrasound and the identification of the bacterial endosymbiont, Wolbachia, have greatly improved our understanding of the pathogenesis of filarial infection and have led to novel approaches to the diagnosis and treatment of travelers and immigrants from filarial-endemic regions. JF - Current infectious disease reports AU - Klion, Amy D AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 126, 4 Center Drive, Bethesda, MD 20892, USA. aklion@niaid.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 50 EP - 57 VL - 10 IS - 1 SN - 1523-3847, 1523-3847 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734025530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+infectious+disease+reports&rft.atitle=Filarial+infections+in+travelers+and+immigrants.&rft.au=Klion%2C+Amy+D&rft.aulast=Klion&rft.aufirst=Amy&rft.date=2008-03-01&rft.volume=10&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Current+infectious+disease+reports&rft.issn=15233847&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-25 N1 - Date created - 2008-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Taxanes and gemcitabine doublets in the management of HER-2 negative metastatic breast cancer: towards optimization of association and schedule. AN - 70773510; 18505062 AB - The management of human epidermal receptor-2 (HER-2) negative metastatic breast cancer (MBC) is usually problematic, since no standard therapy exists in this setting. For some patients, combination chemotherapy represents a valuable approach, although its use is often limited by the risks of increased toxicity as well as impairments in quality of life (QoL) that often outweigh the marginal efficacy benefit. Against this background, the use of taxanes, either paclitaxel or docetaxel, in combination with gemcitabine as first-line treatment of HER-2 negative MBC is supported by the evidence of the single-agent activity of these drugs, beneficial pharmacological interactions, different mechanisms of action and largely non superimposable toxicity profiles. A number of phase II studies have explored the activity of a taxane plus gemcitabine in both chemonaïve and pretreated MBC patients, all showing remarkably high response rates and exceptional tolerability. In randomized phase III trials, the paclitaxel and gemcitabine combination showed significant improvements in objective responses, time to progression and overall survival, as compared to paclitaxel monotherapy, whereas the docetaxel and gemcitabine doublet demonstrated equal efficacy and better tolerability, as compared to docetaxel plus capecitabine. In addition to standard threeweekly dosing regimens, alternative schedules of administration of taxanes and gemcitabine doublets (weekly, twoweekly) might deserve further investigation due to their potential usefulness in reducing pharmacological toxicity while maintaining or increasing dose-intensity and clinical efficacy. Furthermore, uncertainty exists on which taxane should be preferred in combination with gemcitabine, since no head-to-head comparison between paclitaxel-gemcitabine and docetaxel-gemcitabine has been performed so far. Ongoing trials will address these issues and future investigations will also include the evaluation of bevacizumab, the monoclonal antibody targeted against vascular endothelial growth factor (VEGF), in combination with taxanes and gemcitabine doublets. JF - Anticancer research AU - Metro, Giulio AU - Fabi, Alessandra AU - Russillo, Michelangelo AU - Papaldo, Paola AU - De Laurentiis, Michelino AU - Ferretti, Gianluigi AU - Pellegrini, Domenica AU - Nuzzo, Carmen AU - Graziano, Vanessa AU - Vici, Patrizia AU - Introna, Marianna AU - Felici, Alessandra AU - Cognetti, Francesco AU - Carlini, Paolo AD - Division of Medical Oncology A, Regina Elena National Cancer Institute, Rome, Italy. PY - 2008 SP - 1245 EP - 1258 VL - 28 IS - 2B SN - 0250-7005, 0250-7005 KW - Taxoids KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - docetaxel KW - 15H5577CQD KW - gemcitabine KW - B76N6SBZ8R KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Randomized Controlled Trials as Topic KW - Drug Administration Schedule KW - Paclitaxel -- adverse effects KW - Deoxycytidine -- adverse effects KW - Clinical Trials, Phase III as Topic KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Taxoids -- adverse effects KW - Deoxycytidine -- administration & dosage KW - Taxoids -- administration & dosage KW - Breast Neoplasms -- drug therapy KW - Receptor, ErbB-2 -- metabolism KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Breast Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70773510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Taxanes+and+gemcitabine+doublets+in+the+management+of+HER-2+negative+metastatic+breast+cancer%3A+towards+optimization+of+association+and+schedule.&rft.au=Metro%2C+Giulio%3BFabi%2C+Alessandra%3BRussillo%2C+Michelangelo%3BPapaldo%2C+Paola%3BDe+Laurentiis%2C+Michelino%3BFerretti%2C+Gianluigi%3BPellegrini%2C+Domenica%3BNuzzo%2C+Carmen%3BGraziano%2C+Vanessa%3BVici%2C+Patrizia%3BIntrona%2C+Marianna%3BFelici%2C+Alessandra%3BCognetti%2C+Francesco%3BCarlini%2C+Paolo&rft.aulast=Metro&rft.aufirst=Giulio&rft.date=2008-03-01&rft.volume=28&rft.issue=2B&rft.spage=1245&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relevance of experimental models for investigation of genotoxicity induced by antiretroviral therapy during human pregnancy. AN - 70739419; 18295533 AB - The current incidence of human immunodeficiency virus (HIV-1)/AIDS affects around 7000 pregnant women in the United States. When given during pregnancy, the nucleoside analog 3'-azido-3'-deoxythymidine (AZT) significantly reduces maternal-fetal transmission. It has been previously shown that AZT is incorporated into DNA, where it causes mutations in the HPRT and TK genes. It also changes cell cycle gene expression, and induces S-phase arrest, micronuclei, chromosomal aberrations, sister chromatid exchanges, telomeric attrition, and other genotoxic effects in cultured cells. A predicted consequence of these events is genomic instability that together, with clastogenicity may contribute to the carcinogenic potency of AZT. Various aspects of genotoxicity are explored in this contribution seeking to understand the multiple effects of this antiretroviral agent in animal models and humans. This mini-review describes some of the experimental models used to elucidate the genotoxicity induced by antiretroviral therapy during human pregnancy. The use of diverse methods to detect biomarkers of exposure, such as an AZT-specific radioimmunoassay, micronuclei bearing intact chromosomes, and telomeric DNA attrition highlight the role of in vitro models to elucidate exposure and risk. The relevance of the in vitro models is followed by the introduction of the role of the nucleoside analogs in transplacental carcinogenesis along with the description of a transplacental perfusion model and a transplacental carcinogenesis rodent model. In a more direct clinical application the use of AZT-DNA incorporation as a biomarker of exposure, in experiments conducted in vivo in Erythrocebus patas monkeys and in humans, addresses the possibility of elucidation of potential cancer risk in those infants exposed in utero. Two relevant aspects of this contribution are the potential application of some of the models described in this mini-review, as diagnostic tools in antiretroviral-exposed populations, and the use of these models to understand the nature of the genotoxicities and minimize the undesirable side effects of the antiretroviral therapy. JF - Mutation research AU - Olivero, Ofelia A AD - National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA. oliveroo@exchange.nih.gov PY - 2008 SP - 184 EP - 190 VL - 658 IS - 3 SN - 0027-5107, 0027-5107 KW - Anti-HIV Agents KW - 0 KW - Anti-Retroviral Agents KW - Chromatin KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - Zidovudine -- therapeutic use KW - Animals KW - Maternal-Fetal Exchange -- drug effects KW - Humans KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Anti-HIV Agents -- adverse effects KW - Maternal-Fetal Exchange -- genetics KW - Models, Biological KW - Pregnancy KW - Telomere -- chemistry KW - Anti-HIV Agents -- therapeutic use KW - Zidovudine -- adverse effects KW - Telomere -- drug effects KW - Chromatin -- drug effects KW - Micronuclei, Chromosome-Defective -- embryology KW - Female KW - DNA Damage -- physiology KW - Anti-Retroviral Agents -- adverse effects KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - Pregnancy Complications, Infectious -- drug therapy KW - Anti-Retroviral Agents -- therapeutic use KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70739419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Relevance+of+experimental+models+for+investigation+of+genotoxicity+induced+by+antiretroviral+therapy+during+human+pregnancy.&rft.au=Olivero%2C+Ofelia+A&rft.aulast=Olivero&rft.aufirst=Ofelia&rft.date=2008-03-01&rft.volume=658&rft.issue=3&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrrev.2007.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-31 N1 - Date created - 2008-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1997 Nov 5;89(21):1602-8 [9362158] J Cell Physiol. 2005 Jan;202(1):135-46 [15389539] Biochem Biophys Res Commun. 1998 May 8;246(1):107-10 [9600076] Fundam Appl Toxicol. 1996 Aug;32(2):148-58 [8921318] N Engl J Med. 1996 Nov 28;335(22):1621-9 [8965861] AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):223-8 [8835200] Mol Cell Biol. 1996 Jan;16(1):53-65 [8524329] AIDS Res Hum Retroviruses. 1995 Jul;11(7):805-11 [7546907] N Engl J Med. 1994 Nov 3;331(18):1173-80 [7935654] Mol Carcinog. 1993;8(2):81-8 [8397798] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):151-61 [15313587] Arch Pediatr Adolesc Med. 2004 May;158(5):422-5 [15123471] J Acquir Immune Defic Syndr. 2002 Apr 1;29(4):323-9 [11917235] Antiviral Res. 2001 Feb;49(2):55-74 [11248359] Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12667-71 [11058153] Mutat Res. 1999 Jul 16;428(1-2):41-7 [10517977] Lancet. 1999 Sep 25;354(9184):1084-9 [10509500] AIDS. 1999 May 28;13(8):919-25 [10371172] Mol Carcinog. 1998 Sep;23(1):45-51 [9766437] Toxicol Appl Pharmacol. 1999 Nov 15;161(1):82-99 [10558926] Clin Cancer Res. 2007 Sep 1;13(17):5183-94 [17785575] Environ Mol Mutagen. 2007 Apr-May;48(3-4):283-98 [17358026] Semin Fetal Neonatal Med. 2005 Apr;10(2):161-75 [15701581] Mutat Res. 1997 May 23;390(3):223-31 [9186571] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrrev.2007.12.001 ER - TY - JOUR T1 - Antisocial behavioral syndromes and past-year physical health among adults in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 70487391; 18348594 AB - To describe associations of DSM-IV antisocial personality disorder (ASPD), DSM-IV conduct disorder without progression to ASPD (CD-only), and syndromal antisocial behavior in adulthood without conduct disorder before age 15 years (AABS, not a DSM-IV diagnosis) with past-year physical health status and hospital care utilization in the general U.S. adult population. This report is based on the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093, response rate = 81%). Respondents were classified according to whether they met criteria for ASPD, AABS, CD-only, or no antisocial syndrome. Associations of antisocial syndromes with physical health status and care utilization were examined using normal theory and logistic regression. ASPD and AABS were significantly but modestly associated with total past-year medical conditions, coronary heart and gastrointestinal diseases, and numbers of inpatient hospitalizations, inpatient days, emergency department visits, and clinically significant injuries (all p < .05). ASPD was also associated with liver disease, arthritis, and lower scores on the Medical Outcomes Study 12-Item Short-Form Health Survey, version 2 (SF-12v2) physical component summary, role physical, and bodily pain scales (all p < .05). AABS was associated with noncoronary heart disease, lower scores on the SF-12v2 general health and vitality scales, and, among men, arthritis (all p < .05). CD-only was associated with single but not multiple inpatient hospitalizations, emergency department visits, and clinically significant injuries (all p < .05). Estimates of burden related to antisocial behavioral syndromes need to consider associated physical health problems. Prevention and treatment guidelines for injuries and common chronic diseases may need to address comorbid antisociality, and interventions targeting antisociality may need to consider general health status, including prevention and management of injuries and chronic diseases. JF - The Journal of clinical psychiatry AU - Goldstein, Risë B AU - Dawson, Deborah A AU - Chou, S Patricia AU - Ruan, W June AU - Saha, Tulshi D AU - Pickering, Roger P AU - Stinson, Frederick S AU - Grant, Bridget F AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. goldster@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 368 EP - 380 VL - 69 IS - 3 KW - Index Medicus KW - Mood Disorders -- diagnosis KW - Insurance, Health -- statistics & numerical data KW - Tobacco Use Disorder -- epidemiology KW - Anxiety Disorders -- diagnosis KW - Humans KW - Body Mass Index KW - Comorbidity KW - Adult KW - Tobacco Use Disorder -- diagnosis KW - Mood Disorders -- epidemiology KW - Adolescent KW - Anxiety Disorders -- epidemiology KW - United States -- epidemiology KW - Time Factors KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Male KW - Prevalence KW - Antisocial Personality Disorder -- epidemiology KW - Conduct Disorder -- diagnosis KW - Health Surveys KW - Health Status KW - Conduct Disorder -- epidemiology KW - Antisocial Personality Disorder -- diagnosis KW - Alcohol Drinking -- epidemiology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70487391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Antisocial+behavioral+syndromes+and+past-year+physical+health+among+adults+in+the+United+States%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BDawson%2C+Deborah+A%3BChou%2C+S+Patricia%3BRuan%2C+W+June%3BSaha%2C+Tulshi+D%3BPickering%2C+Roger+P%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2008-03-01&rft.volume=69&rft.issue=3&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-22 N1 - Date created - 2008-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychiatry 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2005 Oct;66(10):1205-15 [16259532] J Clin Gastroenterol. 2006 Mar;40 Suppl 1:S5-10 [16540768] Curr Opin Gastroenterol. 2006 May;22(3):263-71 [16550041] J Clin Psychiatry. 2006 Feb;67(2):247-57 [16566620] Crim Behav Ment Health. 2006;16(1):29-42 [16572485] Psychol Med. 2006 May;36(5):699-710 [16438742] Can J Psychiatry. 2006 Mar;51(4):226-33 [16629347] J Abnorm Child Psychol. 2006 Jun;34(3):293-302 [16718539] Am J Clin Nutr. 2006 Jul;84(1):136-42; quiz 268-9 [16825687] Inj Prev. 2006 Aug;12(4):212-8 [16887941] Drug Alcohol Depend. 1987 Nov;20(2):155-62 [2890507] Obesity (Silver Spring). 2006 Jun;14 Suppl 3:135S-142S [16931495] Aliment Pharmacol Ther. 2006 Oct 15;24(8):1151-61 [17014574] Inj Prev. 2006 Oct;12(5):347-50 [17018680] Am J Phys Med Rehabil. 2006 Nov;85(11 Suppl):S2-11; quiz S12-4 [17079976] Semin Arthritis Rheum. 2006 Dec;36(3):182-8 [17045630] J Orthop Trauma. 2006 Nov-Dec;20(10):739-44 [17106388] Orthop Clin North Am. 2006 Oct;37(4):629-33 [17141021] Alcohol Clin Exp Res. 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2017-01-18 ER - TY - JOUR T1 - Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects. AN - 70475642; 18383123 AB - A spectrum of adverse pregnancy outcomes, including preterm birth, low birth weight, and birth defects has been linked with maternal smoking during pregnancy. This article includes a review of studies investigating interactions between genetic variants and maternal smoking in contributing to birth defects using oral clefting as a model birth defect. The primary gene-smoking studies for other major birth defects are also summarized. Gene-environment interaction studies for birth defects are still at an early stage with several mixed results, but evolving research findings have begun to document clinically and developmentally important interactions. As samples and data become increasingly available, more effort is needed in designing innovative analytical methods to study gene-environment interactions. JF - Birth defects research. Part C, Embryo today : reviews AU - Shi, Min AU - Wehby, George L AU - Murray, Jeffrey C AD - Biostatistics Branch, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 16 EP - 29 VL - 84 IS - 1 KW - Index Medicus KW - Humans KW - Genetic Predisposition to Disease KW - Maternal Exposure KW - Female KW - Pregnancy KW - Genetic Variation KW - Pregnancy Complications KW - Cleft Lip -- etiology KW - Congenital Abnormalities -- etiology KW - Smoking -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70475642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.atitle=Review+on+genetic+variants+and+maternal+smoking+in+the+etiology+of+oral+clefts+and+other+birth+defects.&rft.au=Shi%2C+Min%3BWehby%2C+George+L%3BMurray%2C+Jeffrey+C&rft.aulast=Shi&rft.aufirst=Min&rft.date=2008-03-01&rft.volume=84&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.issn=1542-9768&rft_id=info:doi/10.1002%2Fbdrc.20117 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-29 N1 - Date created - 2008-04-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Dis Child. 1989 Mar;143(3):333-7 [2644816] Am J Hum Genet. 1989 Sep;45(3):348-53 [2570526] Genet Epidemiol. 1990;7(3):177-85 [2369997] Am J 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2006 Jan;194(1):218-24 [16389035] Przegl Lek. 2005;62(10):1019-22 [16521944] Birth Defects Res A Clin Mol Teratol. 2006 Mar;76(3):182-6 [16498669] Am J Epidemiol. 2006 May 1;163(9):790-810 [16495466] Am J Public Health. 2006 May;96(5):774-80 [16571708] Am J Med Genet A. 2006 Sep 15;140(18):1915-22 [16906563] Birth Defects Res A Clin Mol Teratol. 2006 Oct;76(10):723-30 [17051589] Am J Med Genet A. 2006 Nov 15;140(22):2433-40 [17036337] Plast Reconstr Surg. 2006 Dec;118(7):1667-8 [17102756] Am J Hum Genet. 2007 Jan;80(1):76-90 [17160896] Epidemiology. 2007 Mar;18(2):226-33 [17202867] Teratology. 2000 Sep;62(3):145-6 [10935977] Paediatr Perinat Epidemiol. 2000 Jul;14(3):227-33 [10949214] Hum Mol Genet. 2000 Oct;9(16):2435-41 [11005799] Mutat Res. 2000 Oct;463(3):247-83 [11018744] Am J Epidemiol. 2001 May 15;153(10):1007-15 [11384957] Am J Hum Genet. 2001 Jul;69(1):67-74 [11369996] Am J Med Genet. 2001 Jul 22;102(1):21-4 [11471167] Epidemiology. 2001 Sep;12(5):502-7 [11505167] Drug Metabol Drug Interact. 2001;18(1):33-55 [11522124] Hum Reprod. 2001 Nov;16(11):2445-50 [11679536] J Pharmacol Exp Ther. 2002 Feb;300(2):355-60 [11805191] J Pharmacol Exp Ther. 2002 Feb;300(2):361-6 [11805192] Cleft Palate Craniofac J. 2002 Mar;39(2):188-92 [11879077] Teratology. 1990 Oct;42(4):397-403 [2147789] Biol Struct Morphog. 1990-1991;3(1):31-5 [2091804] Teratology. 1992 Apr;45(4):353-60 [1533957] Teratology. 1993 Mar;47(3):225-8 [8475465] Stat Med. 1994 Jan 30;13(2):153-62 [8122051] BMJ. 1994 Jun 4;308(6942):1473-6 [8019281] Teratology. 1994 Jul;50(1):13-8 [7974250] Teratology. 1994 Jul;50(1):44-53 [7974254] Am J Epidemiol. 1995 Apr 1;141(7):629-36 [7702037] Reprod Toxicol. 1995 Sep-Oct;9(5):449-59 [8563188] Am J Hum Genet. 1996 Mar;58(3):551-61 [8644715] Teratology. 1996 Apr;53(4):261-7 [8864168] Prev Med. 1996 Nov-Dec;25(6):764-70 [8936580] Am J Epidemiol. 1999 Feb 1;149(3):248-55 [9927220] Teratology. 1999 Jan;59(1):39-50 [9988882] Am J Epidemiol. 1999 Mar 1;149(5):442-6 [10067903] 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Aug;6(3):129-42 [12962196] Genet Epidemiol. 2003 Dec;25(4):367-74 [14639706] Cell Res. 2003 Dec;13(6):429-42 [14728799] Am J Med Genet A. 2004 Feb 15;125A(1):17-22 [14755461] Am J Med Genet A. 2004 Mar 15;125A(3):285-9 [14994238] Bull World Health Organ. 2004 Mar;82(3):213-8 [15112010] Epidemiology. 2004 Mar;15(2):150-6 [15127906] J Biol Chem. 2004 Jul 16;279(29):30189-94 [15145931] Epidemiology. 2004 Nov;15(6):671-8 [15475715] Am J Hum Genet. 1970 May;22(3):336-52 [4910698] Science. 1981 May 8;212(4495):671-2 [7221553] Proc Natl Acad Sci U S A. 1981 Sep;78(9):5722-3 [6946511] Gynecol Obstet Invest. 1984;17(4):179-82 [6724346] Cancer Res. 1986 May;46(5):2220-4 [3084065] Am J Public Health. 1987 May;77(5):623-5 [3565662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/bdrc.20117 ER - TY - JOUR T1 - Mirabalin, [corrected] an antitumor macrolide lactam from the marine sponge Siliquariaspongia mirabilis. AN - 70442221; 18271553 AB - A new highly unsaturated macrolide lactam, termed mirabilin ( 1), was isolated from the aqueous extract of the marine sponge Siliquariaspongia mirabilis. Mirabilin is characterized by the presence of a 35-membered macrolide lactam ring bearing a pentadiene conjugated system and a tetrasubstituted tetrahydropyran ring. A linear polyketide moiety is attached to the macrocyclic ring through an amide linkage. The structure of mirabilin was determined using extensive 2D NMR and ESIMS and tandem MS techniques. Mirabilin inhibits the growth of the tumor cell line HCT-116 with an IC 50 value of 0.27 +/- 0.09 microM and is noncytotoxic to several other cell lines. JF - Journal of natural products AU - Plaza, Alberto AU - Baker, Heather L AU - Bewley, Carole A AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0820, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 473 EP - 477 VL - 71 IS - 3 SN - 0163-3864, 0163-3864 KW - Antineoplastic Agents KW - 0 KW - Macrolides KW - Saponins KW - mirabilin KW - Oleanolic Acid KW - 6SMK8R7TGJ KW - Index Medicus KW - Molecular Structure KW - Drug Screening Assays, Antitumor KW - Animals KW - Humans KW - Marine Biology KW - Micronesia KW - Inhibitory Concentration 50 KW - Macrolides -- chemistry KW - Macrolides -- pharmacology KW - Macrolides -- isolation & purification KW - Oleanolic Acid -- isolation & purification KW - Porifera -- chemistry KW - Oleanolic Acid -- pharmacology KW - Antineoplastic Agents -- isolation & purification KW - Oleanolic Acid -- analogs & derivatives KW - Saponins -- chemistry KW - Saponins -- pharmacology KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Saponins -- isolation & purification KW - Oleanolic Acid -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70442221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+natural+products&rft.atitle=Mirabalin%2C+%5Bcorrected%5D+an+antitumor+macrolide+lactam+from+the+marine+sponge+Siliquariaspongia+mirabilis.&rft.au=Plaza%2C+Alberto%3BBaker%2C+Heather+L%3BBewley%2C+Carole+A&rft.aulast=Plaza&rft.aufirst=Alberto&rft.date=2008-03-01&rft.volume=71&rft.issue=3&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Journal+of+natural+products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp070603p LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-05 N1 - Date created - 2008-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Nat Prod. 2009 Feb 27;72(2):324 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/np070603p ER - TY - JOUR T1 - Is sunlight important to melanoma causation? AN - 70422437; 18319329 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Tucker, Margaret A AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7122, Bethesda, MD 20892-7236, USA. tuckerp@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 467 EP - 468 VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Causality KW - Risk Factors KW - Humans KW - Male KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Sunlight -- adverse effects KW - Skin Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Melanoma -- etiology KW - Skin Neoplasms -- epidemiology KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70422437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Is+sunlight+important+to+melanoma+causation%3F&rft.au=Tucker%2C+Margaret+A&rft.aulast=Tucker&rft.aufirst=Margaret&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-07-2743 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-17 N1 - Date created - 2008-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-07-2743 ER - TY - JOUR T1 - Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound. AN - 70401420; 18060792 AB - Diazeniumdiolate anions and their prodrug forms are reliable sources of nitric oxide (NO) that have generated interest as promising therapeutic agents. A number of structural analogues of O(2)-(2,4-dinitro-5-(4-(N-methylamino)benzoyloxy)phenyl) 1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate (PABA/NO), an anti-cancer lead compound that is designed to release NO upon activation by glutathione, were prepared. The nitric oxide release patterns of these O(2)-(2,4-dinitrophenyl) diazeniumdiolates in the presence of glutathione were tested and it was found that in the absence of competing pathways, these compounds release nearly quantitative amounts of NO. The ability of PABA/NO and its structural analogues to inhibit human leukemia cell proliferation was determined and it was found that compounds releasing elevated amounts of NO displayed superior cytotoxic effects. JF - Bioorganic & medicinal chemistry AU - Chakrapani, Harinath AU - Wilde, Thomas C AU - Citro, Michael L AU - Goodblatt, Michael M AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 2657 EP - 2664 VL - 16 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Prodrugs KW - para-Aminobenzoates KW - Nitric Oxide KW - 31C4KY9ESH KW - Glutathione KW - GAN16C9B8O KW - 4-Aminobenzoic Acid KW - TL2TJE8QTX KW - Index Medicus KW - Molecular Structure KW - Prodrugs -- chemistry KW - Cell Survival -- drug effects KW - HL-60 Cells KW - Prodrugs -- pharmacology KW - Humans KW - Structure-Activity Relationship KW - Prodrugs -- chemical synthesis KW - Leukemia -- pathology KW - Leukemia -- metabolism KW - Glutathione -- metabolism KW - Nitric Oxide -- metabolism KW - Antineoplastic Agents -- chemical synthesis KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - 4-Aminobenzoic Acid -- pharmacology KW - 4-Aminobenzoic Acid -- chemical synthesis KW - 4-Aminobenzoic Acid -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70401420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Synthesis%2C+nitric+oxide+release%2C+and+anti-leukemic+activity+of+glutathione-activated+nitric+oxide+prodrugs%3A+Structural+analogues+of+PABA%2FNO%2C+an+anti-cancer+lead+compound.&rft.au=Chakrapani%2C+Harinath%3BWilde%2C+Thomas+C%3BCitro%2C+Michael+L%3BGoodblatt%2C+Michael+M%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2008-03-01&rft.volume=16&rft.issue=5&rft.spage=2657&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=1464-3391&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-14 N1 - Date created - 2008-03-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 2000 Jan 27;43(2):261-9 [10649981] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] J Org Chem. 2001 May 4;66(9):3090-8 [11325274] J Am Chem Soc. 2001 Jun 13;123(23):5473-81 [11389629] Chem Rev. 2002 Apr;102(4):1135-54 [11942789] Annu Rev Pharmacol Toxicol. 2003;43:585-607 [12415121] Mol Pharmacol. 2004 May;65(5):1070-9 [15102935] Free Radic Biol Med. 2004 Sep 15;37(6):735-6 [15304248] Chem Res Toxicol. 1991 Mar-Apr;4(2):131-40 [1782341] Methods Enzymol. 1996;268:281-93 [8782594] Chem Res Toxicol. 1997 Jan;10(1):2-18 [9074797] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] Org Lett. 2004 Nov 11;6(23):4203-5 [15524443] Bioorg Med Chem. 2005 Apr 15;13(8):2749-57 [15781386] J Med Chem. 2005 Jun 16;48(12):4061-7 [15943479] Expert Opin Investig Drugs. 2005 Jul;14(7):835-46 [16022573] Curr Top Med Chem. 2005;5(7):625-36 [16101424] J Am Chem Soc. 2005 Oct 19;127(41):14188-9 [16218605] J Med Chem. 2006 Feb 9;49(3):1157-64 [16451080] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] Bioorg Med Chem. 2007 Jul 15;15(14):4767-74 [17509888] J Pharmacol Exp Ther. 2000 Aug;294(2):480-7 [10900222] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - National Cancer Institute-United States strategy regarding intraperitoneal chemotherapy for ovarian cancer. AN - 70390381; 18336395 AB - On the basis of three large randomized phase III trials, the National Cancer Institute (NCI) issued a Clinical Announcement in January 2006 recommending that women with optimally debulked stage III ovarian cancer and their physicians consider a combination of intravenous (IV) and intraperitoneal (IP) chemotherapy. The combination of IV and IP chemotherapy is associated with a clinically significant benefit in survival, although it does also confer an increased risk of toxicity compared to IV chemotherapy alone. The NCI Clinical Announcement was issued as part of a broader educational campaign, designed in conjunction with professional societies, cancer centers, Clinical Trials Cooperative Groups, and cancer advocacy organizations. The further development of IP chemotherapy in ovarian cancer requires additional clinical and translational research. JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society AU - Trimble, E L AU - Christian, M C AD - Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892-7436, USA. tt6m@nih.gov PY - 2008 SP - 26 EP - 28 VL - 18 Suppl 1 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - United States KW - Infusions, Intravenous KW - National Cancer Institute (U.S.) KW - Humans KW - Practice Guidelines as Topic KW - Infusions, Parenteral KW - Female KW - Antineoplastic Agents -- administration & dosage KW - Ovarian Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70390381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.atitle=National+Cancer+Institute-United+States+strategy+regarding+intraperitoneal+chemotherapy+for+ovarian+cancer.&rft.au=Trimble%2C+E+L%3BChristian%2C+M+C&rft.aulast=Trimble&rft.aufirst=E&rft.date=2008-03-01&rft.volume=18+Suppl+1&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.issn=1525-1438&rft_id=info:doi/10.1111%2Fj.1525-1438.2007.01100.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-13 N1 - Date created - 2008-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1525-1438.2007.01100.x ER - TY - JOUR T1 - Innate immunity and alcoholic liver fibrosis. AN - 70390307; 18336653 AB - The hepatic innate immune system consists of predominant innate immunity, which plays an important role in innate defense against infection and tumor transformation. Emerging evidence suggests that innate immunity also contributes to liver injury, repair, and fibrosis. The present review summarizes the recent findings on the role of innate immunity in liver fibrosis. In general, Kupffer cells stimulate liver fibrosis via production of reactive oxygen species and pro-inflammatory cytokines, whereas natural killer (NK) cells inhibit liver fibrosis by directly killing activated hepatic stellate cells and production of gamma-interferon (IFN-gamma). Complement components, interferons, and Toll-like receptors have also been shown to regulate liver fibrosis. Recent evidence also suggests that modulation of innate immunity by alcohol plays an important role in the pathogenesis of alcoholic liver fibrosis. These include alcohol amplification of the profibrotic effects of Kupffer cells and suppression of the antifibrotic effects of NK/IFN-gamma. JF - Journal of gastroenterology and hepatology AU - Jeong, Won-Il AU - Gao, Bin AD - Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - S112 EP - S118 VL - 23 Suppl 1 KW - Index Medicus KW - Animals KW - Humans KW - Liver Cirrhosis, Alcoholic -- immunology KW - Immunity, Innate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70390307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=Innate+immunity+and+alcoholic+liver+fibrosis.&rft.au=Jeong%2C+Won-Il%3BGao%2C+Bin&rft.aulast=Jeong&rft.aufirst=Won-Il&rft.date=2008-03-01&rft.volume=23+Suppl+1&rft.issue=&rft.spage=S112&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=1440-1746&rft_id=info:doi/10.1111%2Fj.1440-1746.2007.05274.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-29 N1 - Date created - 2008-03-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Alcohol Clin Exp Res. 2001 Jun;25(6 Suppl):51S-4S [11410742] J Immunol. 2001 Nov 15;167(10):5645-52 [11698436] Annu Rev Immunol. 2002;20:197-216 [11861602] Immunol Cell Biol. 2002 Feb;80(1):84-92 [11869365] Gastroenterology. 2002 May;122(5):1303-13 [11984517] Hepatology. 2002 Nov;36(5 Suppl 1):S220-5 [12407597] Hepatology. 2003 Jan;37(1):87-95 [12500193] J Clin Gastroenterol. 2003 Mar;36(3):242-52 [12590237] J Biol Chem. 2003 Mar 7;278(10):8435-41 [12482856] Hepatology. 2003 May;37(5):1043-55 [12717385] Hepatology. 2003 Oct;38(4):890-9 [14512876] Hepatology. 2003 Nov;38(5):1116-24 [14578850] Hepatology. 2004 Feb;39(2):333-42 [14767986] J Immunol. 2004 May 1;172(9):5782-9 [15100325] Gastroenterology. 2004 May;126(5):1387-99 [15131799] J Immunol. 2004 Jul 1;173(1):42-9 [15210757] Semin Liver Dis. 2004 Aug;24(3):305-15 [15349807] Hepatogastroenterology. 2004 Sep-Oct;51(59):1451-3 [15362774] Hepatology. 2004 Nov;40(5):1033-40 [15486982] Dig Dis Sci. 1986 Nov;31(11):1242-8 [3769708] Hepatology. 2008 Feb;47(2):729-36 [18167066] Expert Rev Gastroenterol Hepatol. 2007 Oct;1(1):173-80 [19072444] Gastroenterology. 1998 Aug;115(2):443-51 [9679050] Gastroenterology. 2004 Nov;127(5):1525-39 [15521020] J Clin Invest. 2005 Jan;115(1):56-65 [15630444] Gastroenterology. 2005 Feb;128(2):304-12 [15685542] J Clin Invest. 2005 Feb;115(2):209-18 [15690074] Nat Genet. 2005 Aug;37(8):835-43 [15995705] Hepatology. 2005 Oct;42(4):802-8 [16175622] Clin Gastroenterol Hepatol. 2005 Aug;3(8):819-28 [16234012] Am J Pathol. 2005 Nov;167(5):1231-41 [16251408] Hepatology. 2005 Nov;42(5):1037-45 [16231358] Hepatology. 2006 Feb;43(2 Suppl 1):S54-62 [16447271] Gastroenterology. 2006 Feb;130(2):435-52 [16472598] Dig Dis. 2005;23(3-4):264-74 [16508291] Alcohol Clin Exp Res. 2000 Mar;24(3):291-9 [10776665] J Hepatol. 1991 Mar;12(2):162-9 [2050995] Hepatology. 1992 Sep;16(3):776-84 [1505921] Am J Pathol. 1993 Feb;142(2):367-73 [8382006] J Hepatol. 1995 Feb;22(2):135-42 [7790701] J Investig Med. 1994 Dec;42(4):660-70 [8521029] Hepatology. 1996 May;23(5):1189-99 [8621153] Lancet. 1997 Mar 22;349(9055):825-32 [9121257] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10663-8 [9380692] Hepatology. 2006 Apr;43(4):872-8 [16502397] Hepatology. 2006 Mar;43(3):573-80 [16496327] J Viral Hepat. 2006 May;13(5):322-8 [16637863] Gastroenterology. 2006 May;130(6):1886-900 [16697751] Hepatology. 2006 Jun;43(6):1211-9 [16729307] Ann Med. 2006;38(4):280-6 [16754259] Hepatology. 2006 May;43(5):989-1000 [16628628] J Hepatol. 2006 Jul;45(1):60-71 [16515819] Lab Invest. 2006 Jul;86(7):676-86 [16619004] Hepatology. 2006 Aug;44(2):287-98 [16871558] Alcohol Clin Exp Res. 2006 Sep;30(9):1615-23 [16930225] Hepatology. 2006 Sep;44(3):521-6 [16941687] Immunol Rev. 2006 Oct;213:101-18 [16972899] Cell Mol Immunol. 2006 Oct;3(5):333-40 [17092430] Gastroenterology. 2006 Nov;131(5):1573-83 [17064698] Hepatology. 2006 Dec;44(6):1441-51 [17133483] Hepatology. 2006 Dec;44(6):1487-501 [17133487] Hepatology. 2006 Dec;44(6):1675-84 [17133499] Hepatology. 2007 Jan;45(1):242-9 [17187439] Alcohol Clin Exp Res. 2007 Jan;31(1):122-9 [17207110] J Clin Invest. 2007 Mar;117(3):539-48 [17332881] Hepatology. 2007 Mar;45(3):569-78 [17326152] Hepatology. 2007 Mar;45(3):806-16 [17326207] Hepatology. 2007 Feb;45(2):314-22 [17256753] Gastroenterology. 2007 Mar;132(3):1117-26 [17383432] J Immunol. 2007 Apr 15;178(8):5288-95 [17404313] Gastroenterology. 2007 May;132(5):1746-56 [17484872] Gastroenterology. 2007 May;132(5):1979-98 [17484890] Hepatology. 2007 Jun;45(6):1400-12 [17523147] Hepatology. 2007 Jul;46(1):229-41 [17596893] Cell Mol Immunol. 2007 Aug;4(4):241-52 [17764614] Hepatology. 2007 Sep;46(3):706-15 [17626270] Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G809-16 [17673545] Hepatology. 2007 Nov;46(5):1509-18 [17705260] Gastroenterology. 2008 Jan;134(1):248-58 [18166357] Immunol Rev. 2000 Apr;174:5-20 [10807503] Proc Natl Acad Sci U S A. 2000 May 9;97(10):5498-503 [10792025] J Hepatol. 2000 May;32(5):742-7 [10845660] J Viral Hepat. 2000 Sep;7(5):327-34 [10971820] Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G200-7 [11408273] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1746.2007.05274.x ER - TY - JOUR T1 - The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells. AN - 70388800; 17916899 AB - Alarm anti-proteases are secreted locally in response to inflammation and have been shown to be elevated in cancers. Secretory leukocyte protease inhibitor (SLPI), an alarm anti-protease, is amplified in ovarian carcinoma and is induced and binds to and protects progranulin (prgn) in inflammation. We reported prgn is a survival protein in ovarian cancer and now hypothesize that SLPI/prgn would promote proliferation and survival. Neutralizing anti-SLPI antibody treatment of HEY-A8 and OVCAR3 ovarian cancer cells decreased cell number (P < 0.001), induced apoptosis and reduced prgn quantity. This was confirmed using SLPI small interfering RNA. Prgn and SLPI were co-immunoprecipitated and co-localized by confocal microscopy. Prgn is a substrate of the serine protease elastase and SLPI is an inhibitor of elastase. Elastase reduced prgn expression, inhibited proliferation in a dose-dependent manner (P C marker (rs5275) was initially associated with prostate cancer risk (P-trend = 0.02) but became non-significant after adjustment for multiple comparisons (P = 0.08); this SNP showed no association with prostate cancer risk in the Nutrition Cohort (P-trend = 0.54) or in an analysis pooling the two cohorts (P-trend = 0.20). No other SNP was associated with prostate cancer risk in PLCO or the Nutrition Cohort individually or combined. Haplotype analyses suggested an association between PTGS2 variants in PLCO alone (global P = 0.007), but not in the Nutrition Cohort (global P = 0.78) or pooled analysis (global P = 0.18). In conclusion, despite the potential importance of inflammation in prostate carcinogenesis, results from our large study of five PTGS2 SNPs does not support a strong association between PTGS2 variants and prostate cancer risk in non-Hispanic white men. JF - Carcinogenesis AU - Danforth, Kim N AU - Hayes, Richard B AU - Rodriguez, Carmen AU - Yu, Kai AU - Sakoda, Lori C AU - Huang, Wen-Yi AU - Chen, Bingshu E AU - Chen, Jinbo AU - Andriole, Gerald L AU - Calle, Eugenia E AU - Jacobs, Eric J AU - Chu, Lisa W AU - Figueroa, Jonine D AU - Yeager, Meredith AU - Platz, Elizabeth A AU - Michaud, Dominique S AU - Chanock, Stephen J AU - Thun, Michael J AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. danfortk@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 568 EP - 572 VL - 29 IS - 3 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Index Medicus KW - Risk Factors KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Polymorphism, Single Nucleotide KW - Cyclooxygenase 2 -- genetics KW - Prostatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70384914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphic+variants+in+PTGS2+and+prostate+cancer+risk%3A+results+from+two+large+nested+case-control+studies.&rft.au=Danforth%2C+Kim+N%3BHayes%2C+Richard+B%3BRodriguez%2C+Carmen%3BYu%2C+Kai%3BSakoda%2C+Lori+C%3BHuang%2C+Wen-Yi%3BChen%2C+Bingshu+E%3BChen%2C+Jinbo%3BAndriole%2C+Gerald+L%3BCalle%2C+Eugenia+E%3BJacobs%2C+Eric+J%3BChu%2C+Lisa+W%3BFigueroa%2C+Jonine+D%3BYeager%2C+Meredith%3BPlatz%2C+Elizabeth+A%3BMichaud%2C+Dominique+S%3BChanock%2C+Stephen+J%3BThun%2C+Michael+J%3BHsing%2C+Ann+W&rft.aulast=Danforth&rft.aufirst=Kim&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-07 N1 - Date created - 2008-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure to multiple indoor allergens in US homes and its relationship to asthma. AN - 70384213; 18255132 AB - The National Survey of Lead and Allergens in Housing was the first population-based study to measure indoor allergen levels in US homes. We characterized the overall burden to multiple allergens and examined whether increased allergen levels were associated with occupants' asthma status. This cross-sectional study surveyed a nationally representative sample of 831 housing units in 75 different locations throughout the United States. Information was collected by means of questionnaire and environmental assessment. Allergen concentrations in dust samples were assessed by using immunoassays. The following cutoff points were used to define increased allergen levels: 10 microg/g for Der p 1, Der f 1, and Can f 1; 8 microg/g for Fel d 1; 8 U/g for Bla g 1; 1.6 microg/g for mouse urinary protein; and 7 microg/g for Alternaria alternata antigens. Allergen burden was considered high when 4 or more allergens exceeded increased levels in any of the sampling locations. Exposure to multiple allergens was common in US homes. Of the surveyed homes, 51.5% had at least 6 detectable allergens and 45.8% had at least 3 allergens exceeding increased levels. Race, income, housing type, absence of children, and presence of smokers, pets, cockroaches, rodents, and mold/moisture-related problems were independent predictors of high allergen burden. Among atopic subjects, high allergen burden increased the odds of having asthma symptoms (odds ratio, 1.81; 95% CI, 1.04-3.15). Increased allergen levels in the home are associated with asthma symptoms in allergic individuals. JF - The Journal of allergy and clinical immunology AU - Salo, Päivi M AU - Arbes, Samuel J AU - Crockett, Patrick W AU - Thorne, Peter S AU - Cohn, Richard D AU - Zeldin, Darryl C AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 678 EP - 684.e2 VL - 121 IS - 3 KW - Allergens KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Socioeconomic Factors KW - Hypersensitivity -- complications KW - Hypersensitivity -- immunology KW - Cross-Sectional Studies KW - Animals KW - Humans KW - Allergens -- immunology KW - Asthma -- epidemiology KW - Air Pollution, Indoor -- adverse effects KW - Asthma -- etiology KW - Allergens -- adverse effects KW - Allergens -- analysis KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70384213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Exposure+to+multiple+indoor+allergens+in+US+homes+and+its+relationship+to+asthma.&rft.au=Salo%2C+P%C3%A4ivi+M%3BArbes%2C+Samuel+J%3BCrockett%2C+Patrick+W%3BThorne%2C+Peter+S%3BCohn%2C+Richard+D%3BZeldin%2C+Darryl+C&rft.aulast=Salo&rft.aufirst=P%C3%A4ivi&rft.date=2008-03-01&rft.volume=121&rft.issue=3&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2007.12.1164 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-13 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Allergy. 1999 Oct;54(10):1058-66 [10536884] Environ Health Perspect. 2007 Feb;115(2):215-20 [17384767] J Allergy Clin Immunol. 2000 Jun;105(6 Pt 2):S628-32 [10856169] J Allergy Clin Immunol. 2000 Dec;106(6):1070-4 [11112888] J Allergy Clin Immunol. 2000 Dec;106(6):1075-80 [11112889] J Allergy Clin Immunol. 2001 Jan;107(1):48-54 [11149990] J Allergy Clin Immunol. 2001 May;107(5 Suppl):S445-8 [11344373] Environ Health Perspect. 2002 Apr;110(4):419-25 [11940461] Environ Health Perspect. 2002 May;110(5):527-32 [12003758] Environ Health Perspect. 2002 Sep;110(9):939-45 [12204830] J Expo Anal Environ Epidemiol. 2002 Nov;12(6):427-32 [12415491] Chest. 2002 Nov;122(5):1580-6 [12426256] J Allergy Clin Immunol. 2003 Feb;111(2):408-14 [12589364] J Allergy Clin Immunol. 2003 Aug;112(2):362-8 [12897743] J Allergy Clin Immunol. 2004 Jun;113(6):1167-71 [15208600] J Allergy Clin Immunol. 2004 Jul;114(1):111-7 [15241352] N Engl J Med. 2004 Sep 9;351(11):1068-80 [15356304] N Engl J Med. 1990 Aug 23;323(8):502-7 [2377175] J Allergy Clin Immunol. 1995 Oct;96(4):449-56 [7560654] N Engl J Med. 1997 May 8;336(19):1356-63 [9134876] J Allergy Clin Immunol. 1997 Dec;100(6 Pt 1):S2-24 [9438476] Clin Exp Allergy. 1998 Jan;28(1):53-9 [9537780] J Allergy Clin Immunol. 2005 Mar;115(3):478-85 [15753892] Annu Rev Public Health. 2005;26:89-113 [15760282] Environ Res. 2005 Jun;98(2):167-76 [15820722] J Allergy Clin Immunol. 2005 Sep;116(3):623-9 [16159634] Am J Respir Crit Care Med. 2005 Dec 1;172(11):1371-7 [16141442] Environ Health Perspect. 2006 Apr;114(4):522-6 [16581539] Lancet. 2006 Aug 26;368(9537):763-70 [16935687] J Allergy Clin Immunol. 2006 Oct;118(4):892-8 [17030243] Ann Allergy Asthma Immunol. 2006 Sep;97(3):350-6 [17042141] Sci Total Environ. 2006 Dec 1;371(1-3):31-43 [17049968] Ann Allergy Asthma Immunol. 2006 Nov;97(5):628-35 [17165271] J Urban Health. 2007 Mar;84(2):185-97 [17216349] Environ Health Perspect. 2000 Apr;108(4):301-7 [10753087] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jaci.2007.12.1164 ER - TY - JOUR T1 - Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma. AN - 70384128; 18234311 AB - Aeroallergen sensitization in adult asthmatic patients from a wide geographic area has not been correlated with patients' characteristics, markers of airways inflammation, and lung function. We assessed data obtained from the Asthma Clinical Research Network trials to determine the relationship of aeroallergen sensitization to age, sex, ethnicity, and markers of inflammation and airways function. Skin testing (14 epicutaneous) was performed on 1338 subjects with objectively diagnosed mild-to-moderate asthma from 11 Asthma Clinical Research Network studies. Skin testing used identical techniques and a quality assurance program to ensure uniformity across centers. Ninety-five percent of the subjects had at least 1 positive skin test response. Of these, 14% had positive reactions to 1 or 2 allergens and 81% had positive reactions to 3 or more allergens, and 2% of subjects reacted only to seasonal allergens, 26% only to perennial allergens, and 67% to both. Increasing IgE and exhaled nitric oxide values, decreasing PC(20) values, and minority ethnicity significantly correlated with the number of positive skin test responses. Subjects with late-onset asthma were less likely to be sensitized; nonetheless, 89% of subjects older than 60 years had positive responses. Ninety-five percent of patients with mild-to-moderate asthma might have an allergic component. Age does not significantly affect aeroallergen sensitization, but the pattern of allergic sensitization varies with ethnicity and geography. Measures used to characterize asthma, such as IgE, exhaled nitric oxide, and PC(20) values, are correlated with aeroallergen sensitization. JF - The Journal of allergy and clinical immunology AU - Craig, Timothy J AU - King, Tonya S AU - Lemanske, Robert F AU - Wechsler, Michael E AU - Icitovic, Nikolina AU - Zimmerman, Ronald R AU - Wasserman, Stephen AU - National Heart, Lung, and Blood Institute's Asthma Clinical Research Network AD - Division of Pulmonary Care, Pennsylvania State University College of Medicine, Hershey, PA 17033-0853, USA. tcraig@psu.edu ; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 671 EP - 677 VL - 121 IS - 3 KW - Air Pollutants KW - 0 KW - Allergens KW - Nitric Oxide KW - 31C4KY9ESH KW - Immunoglobulin E KW - 37341-29-0 KW - Abridged Index Medicus KW - Index Medicus KW - Allergens -- immunology KW - Immunoglobulin E -- blood KW - Skin Tests KW - Air Pollutants -- immunology KW - Humans KW - Aged KW - Child KW - Adult KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Prevalence KW - Respiratory Function Tests KW - Nitric Oxide -- analysis KW - Hypersensitivity -- epidemiology KW - Hypersensitivity -- complications KW - Hypersensitivity -- immunology KW - Asthma -- epidemiology KW - Asthma -- immunology KW - Asthma -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70384128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Aeroallergen+sensitization+correlates+with+PC%2820%29+and+exhaled+nitric+oxide+in+subjects+with+mild-to-moderate+asthma.&rft.au=Craig%2C+Timothy+J%3BKing%2C+Tonya+S%3BLemanske%2C+Robert+F%3BWechsler%2C+Michael+E%3BIcitovic%2C+Nikolina%3BZimmerman%2C+Ronald+R%3BWasserman%2C+Stephen%3BNational+Heart%2C+Lung%2C+and+Blood+Institute%27s+Asthma+Clinical+Research+Network&rft.aulast=Craig&rft.aufirst=Timothy&rft.date=2008-03-01&rft.volume=121&rft.issue=3&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=1097-6825&rft_id=info:doi/10.1016%2Fj.jaci.2007.12.1153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-13 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jaci.2007.12.1153 ER - TY - JOUR T1 - Broadening inclusion of vulnerable populations in HIV vaccine trials. AN - 70375786; 18324894 AB - The urgent need for a preventive HIV vaccine, as well as the complexities of its development, calls for timely and reinforced efforts to ensure vaccine licensure for use in a broad range of at-risk populations from the outset. Such an integrated strategy to HIV vaccine development should include infants of HIV-infected women, adolescents and injection drug users. A safe and effective HIV vaccine licensed for use in these populations, in addition to sexually active adults, would probably have the most timely and profound impact on the HIV/AIDS pandemic. Advanced clinical development of HIV vaccines in these vulnerable populations imposes particular scientific, operational and ethical challenges. Recent developments, including the early termination of a Phase IIb trial, present additional previously unanticipated challenges. JF - Expert review of vaccines AU - Lau, Chuen-Yen AU - Cardinali, Massimo AU - Sato, Paul A AU - Fix, Alan AU - Flores, Jorge AD - Vaccine Clinical Research Branch, Vaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, 6700 B Rockledge Drive, Room 5126, Bethesda, MD 20817, USA. lauc@niaid.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 259 EP - 268 VL - 7 IS - 2 KW - AIDS Vaccines KW - 0 KW - Index Medicus KW - Infectious Disease Transmission, Vertical KW - Animals KW - Pregnancy Complications, Infectious -- prevention & control KW - HIV-1 -- immunology KW - Humans KW - Infant, Newborn KW - Pregnancy Complications, Infectious -- virology KW - Pregnancy KW - Infant KW - Risk Factors KW - Adult KW - Substance Abuse, Intravenous -- complications KW - Adolescent KW - Female KW - AIDS Vaccines -- administration & dosage KW - Vulnerable Populations KW - HIV Infections -- virology KW - HIV Infections -- transmission KW - AIDS Vaccines -- therapeutic use KW - HIV Infections -- prevention & control KW - AIDS Vaccines -- adverse effects KW - Clinical Trials as Topic -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70375786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+vaccines&rft.atitle=Broadening+inclusion+of+vulnerable+populations+in+HIV+vaccine+trials.&rft.au=Lau%2C+Chuen-Yen%3BCardinali%2C+Massimo%3BSato%2C+Paul+A%3BFix%2C+Alan%3BFlores%2C+Jorge&rft.aulast=Lau&rft.aufirst=Chuen-Yen&rft.date=2008-03-01&rft.volume=7&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+vaccines&rft.issn=1744-8395&rft_id=info:doi/10.1586%2F14760584.7.2.259 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1586/14760584.7.2.259 ER - TY - JOUR T1 - Ixabepilone for the treatment of solid tumors: a review of clinical data. AN - 70373290; 18321240 AB - Microtubule stabilizing agents such as taxanes are an integral part of therapy for multiple solid tumors. However, due to limitations of these agents, newer more effective cytotoxic agents are necessary. Ixabepilone, an epothilone B analog, is a novel microtubule stabilizing agent. This review provides an updated summary of emerging clinical experience with Ixabepilone. Phase I, II and III clinical trials presented in abstract form or journal articles found within a PubMed search through November 2007 are described in this review. Ixabepilone offers promising clinical activity in a variety of solid tumors. Ixabepilone is FDA-approved for the treatment of breast cancer refractory to anthracyclines and taxanes. The optimal dose and schedule are still being defined, and the predominant side effects are bone marrow suppression and neuropathy. JF - Expert opinion on investigational drugs AU - Denduluri, Neelima AU - Swain, Sandra M AD - National Cancer Institute, National Institutes of Health, Breast Cancer Section, Medical Oncology Branch, Center for Cancer Research, 10 Center Drive, Room 12N226, Bethesda, Maryland 20892, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 423 EP - 435 VL - 17 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Epothilones KW - Tubulin Modulators KW - ixabepilone KW - K27005NP0A KW - Index Medicus KW - Animals KW - Humans KW - Treatment Outcome KW - Clinical Trials as Topic KW - Neoplasms -- drug therapy KW - Epothilones -- therapeutic use KW - Antineoplastic Agents -- pharmacokinetics KW - Epothilones -- adverse effects KW - Epothilones -- pharmacokinetics KW - Antineoplastic Agents -- adverse effects KW - Tubulin Modulators -- adverse effects KW - Tubulin Modulators -- pharmacology KW - Tubulin Modulators -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Tubulin Modulators -- pharmacokinetics KW - Epothilones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70373290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+investigational+drugs&rft.atitle=Ixabepilone+for+the+treatment+of+solid+tumors%3A+a+review+of+clinical+data.&rft.au=Denduluri%2C+Neelima%3BSwain%2C+Sandra+M&rft.aulast=Denduluri&rft.aufirst=Neelima&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+investigational+drugs&rft.issn=1744-7658&rft_id=info:doi/10.1517%2F13543784.17.3.423 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-21 N1 - Date created - 2008-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/13543784.17.3.423 ER - TY - JOUR T1 - Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamics. AN - 70370810; 18178775 AB - In many organisms, polo kinases appear to play multiple roles during M-phase progression. To provide new insights into the function of the budding yeast polo kinase Cdc5, we generated novel temperature-sensitive cdc5 mutants by mutagenizing the C-terminal noncatalytic polo box domain, a region that is critical for proper subcellular localization. One of these mutants, cdc5-11, exhibited a temperature-sensitive growth defect with an abnormal spindle morphology. Strikingly, provision of a moderate level of benomyl, a microtubule-depolymerizing drug, permitted cdc5-11 cells to grow significantly better than the isogenic CDC5 wild type in a FEAR (cdc Fourteen Early Anaphase Release)-independent manner. In addition, cdc5-11 required MAD2 for both cell growth and the benomyl-remedial phenotype. These results suggest that cdc5-11 is defective in proper spindle function. Consistent with this view, cdc5-11 exhibited abnormal spindle morphology, shorter spindle length, and delayed microtubule regrowth at the nonpermissive temperature. Overexpression of CDC5 moderately rescued the spc98-2 growth defect. Interestingly, both Cdc28 and Cdc5 were required for the proper modification of the spindle pole body components Nud1, Slk19, and Stu2 in vivo. They also phosphorylated these three proteins in vitro. Taken together, these observations suggest that concerted action of Cdc28 and Cdc5 on Nud1, Slk19, and Stu2 is important for proper spindle functions. JF - Eukaryotic cell AU - Park, Chong J AU - Park, Jung-Eun AU - Karpova, Tatiana S AU - Soung, Nak-Kyun AU - Yu, Li-Rong AU - Song, Sukgil AU - Lee, Kyung H AU - Xia, Xue AU - Kang, Eugene AU - Dabanoglu, Ilknur AU - Oh, Doo-Yi AU - Zhang, James Y AU - Kang, Young Hwi AU - Wincovitch, Stephen AU - Huffaker, Tim C AU - Veenstra, Timothy D AU - McNally, James G AU - Lee, Kyung S AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 444 EP - 453 VL - 7 IS - 3 KW - Cell Cycle Proteins KW - 0 KW - Microtubule-Associated Proteins KW - STU2 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - Slk19 protein, S cerevisiae KW - tRNA Methyltransferases KW - EC 2.1.1.- KW - Protein Kinases KW - EC 2.7.- KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - CDC5 protein, S cerevisiae KW - EC 2.7.11.21 KW - CDC28 Protein Kinase, S cerevisiae KW - EC 2.7.11.22 KW - Deoxyribonucleases KW - EC 3.1.- KW - TRM2 protein, S cerevisiae KW - Index Medicus KW - CDC28 Protein Kinase, S cerevisiae -- metabolism KW - Microtubule-Associated Proteins -- metabolism KW - Deoxyribonucleases -- metabolism KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Protein Kinases -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - Microtubules -- metabolism KW - Spindle Apparatus KW - Saccharomyces cerevisiae -- cytology KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70370810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eukaryotic+cell&rft.atitle=Requirement+for+the+budding+yeast+polo+kinase+Cdc5+in+proper+microtubule+growth+and+dynamics.&rft.au=Park%2C+Chong+J%3BPark%2C+Jung-Eun%3BKarpova%2C+Tatiana+S%3BSoung%2C+Nak-Kyun%3BYu%2C+Li-Rong%3BSong%2C+Sukgil%3BLee%2C+Kyung+H%3BXia%2C+Xue%3BKang%2C+Eugene%3BDabanoglu%2C+Ilknur%3BOh%2C+Doo-Yi%3BZhang%2C+James+Y%3BKang%2C+Young+Hwi%3BWincovitch%2C+Stephen%3BHuffaker%2C+Tim+C%3BVeenstra%2C+Timothy+D%3BMcNally%2C+James+G%3BLee%2C+Kyung+S&rft.aulast=Park&rft.aufirst=Chong&rft.date=2008-03-01&rft.volume=7&rft.issue=3&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=Eukaryotic+cell&rft.issn=1535-9786&rft_id=info:doi/10.1128%2FEC.00283-07 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2000 Jan;20(1):286-98 [10594031] Cell Cycle. 2006 Apr;5(8):853-64 [16627997] J Cell Biol. 2001 Apr 2;153(1):149-58 [11285281] Curr Biol. 2001 Mar 20;11(6):441-6 [11301255] J Cell Biol. 2001 Apr 16;153(2):435-42 [11309422] EMBO J. 2001 Jun 1;20(11):2878-84 [11387220] Nat Cell Biol. 2001 Sep;3(9):771-7 [11533655] Mol Biol Cell. 2001 Sep;12(9):2870-80 [11553724] Cell. 2001 Nov 30;107(5):655-65 [11733064] Cell. 2002 Jan 25;108(2):207-20 [11832211] Trends Cell Biol. 2002 May;12(5):222-5 [12062169] Trends Cell Biol. 2002 Jun;12(6):267-73 [12074886] Mol Cell Biol. 2002 Sep;22(17):6209-21 [12167714] Genetics. 2003 Jan;163(1):21-33 [12586693] J Cell Biol. 2003 Apr 28;161(2):359-69 [12719475] Dev Cell. 2003 May;4(5):711-26 [12737806] J Cell Biol. 2003 May 12;161(3):535-45 [12732615] Dev Cell. 2003 Jul;5(1):113-25 [12852856] Cell. 2003 Oct 3;115(1):83-95 [14532005] Science. 2003 Dec 19;302(5653):2120-4 [14605209] Mol Biol Cell. 2004 Apr;15(4):1580-90 [14718566] Nat Rev Mol Cell Biol. 2004 Jun;5(6):429-40 [15173822] Mol Cell Biol. 2004 Nov;24(22):9873-86 [15509790] J Bacteriol. 1983 Jan;153(1):163-8 [6336730] J Cell Sci. 1988 Jan;89 ( Pt 1):25-38 [3417791] Yeast. 1986 Sep;2(3):163-7 [3333305] Gene. 1988 Dec 30;74(2):527-34 [3073106] Genetics. 1989 May;122(1):19-27 [2659436] Genes Dev. 1991 Dec;5(12A):2153-65 [1660828] Mol Cell Biol. 1993 Jul;13(7):4445-57 [8321244] Genes Dev. 1995 May 1;9(9):1059-73 [7744248] J Cell Biol. 1996 Mar;132(5):861-70 [8603918] Science. 1996 Sep 6;273(5280):1377-80 [8703070] J Cell Biol. 1996 Dec;135(6 Pt 2):1701-13 [8991084] Mol Cell Biol. 1997 Jun;17(6):3408-17 [9154840] Mol Biol Cell. 1997 Dec;8(12):2575-90 [9398677] Curr Biol. 1998 Feb 26;8(5):257-66 [9501066] Curr Biol. 1998 Apr 23;8(9):497-507 [9560342] Mol Cell Biol. 1998 Jul;18(7):4262-71 [9632810] Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9301-6 [9689075] Yeast. 1998 Jul;14(10):953-61 [9717241] Mol Cell Biol. 1998 Dec;18(12):7360-70 [9819423] Curr Biol. 1999 Mar 11;9(5):227-36 [10074450] Cell. 1999 Apr 16;97(2):233-44 [10219244] J Cell Biol. 1999 Jul 26;146(2):415-25 [10427094] Oncogene. 2005 Jan 10;24(2):248-59 [15640840] EMBO J. 2005 Jun 15;24(12):2194-204 [15920482] EMBO J. 2000 Dec 1;19(23):6475-88 [11101520] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/EC.00283-07 ER - TY - JOUR T1 - Regional apparent metabolite concentrations in young adult brain measured by (1)H MR spectroscopy at 3 Tesla. AN - 70364573; 18307197 AB - To quantify and examine the distribution of brain metabolites in normal young adults using single voxel MR spectroscopy at 3 Tesla (T). Short-echo time single-voxel PRESS technique was used to measure the apparent concentration of five metabolites at nine locations in the brains of young adults. Concentrations were estimated by means of an automated fitting method (LCModel) with reference to an unsuppressed water signal and were corrected for T(1) relaxation, T(2) relaxation, and cerebrospinal fluid partial volume. Analysis of variance with Tukey post hoc test was used to evaluate regional variations. Statistically significant differences in regional concentrations were detected for each of the metabolites. The number of significant differences was greatest for total choline, whereas myo-inositol and the sum of glutamine and glutamate had the fewest. Magnitude of variation was greatest for total choline and least for the sum of N-acetyl aspartate and N-acetylaspartylglutamate. In agreement with previous studies at other field strengths, we found heterogeneous distribution of the major spectroscopically measurable brain metabolites. Although the most distinct differences are between tissue types, there is appreciable variation within a tissue type at different locations. The spectra and metabolite concentrations presented should provide a useful reference for both clinical and research MR spectroscopy studies performed at 3T. JF - Journal of magnetic resonance imaging : JMRI AU - Baker, Eva H AU - Basso, Gianpaolo AU - Barker, Peter B AU - Smith, Mari A AU - Bonekamp, David AU - Horská, Alena AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 489 EP - 499 VL - 27 IS - 3 SN - 1053-1807, 1053-1807 KW - Dipeptides KW - 0 KW - Glutamine KW - 0RH81L854J KW - isospaglumic acid KW - 1W8M12WXYL KW - Aspartic Acid KW - 30KYC7MIAI KW - Glutamic Acid KW - 3KX376GY7L KW - Inositol KW - 4L6452S749 KW - N-acetylaspartate KW - 997-55-7 KW - Choline KW - N91BDP6H0X KW - Index Medicus KW - Age Factors KW - Aspartic Acid -- analogs & derivatives KW - Glutamine -- analysis KW - Humans KW - Aspartic Acid -- analysis KW - Adult KW - Dipeptides -- analysis KW - Male KW - Inositol -- analysis KW - Glutamic Acid -- analysis KW - Female KW - Choline -- analysis KW - Magnetic Resonance Spectroscopy -- methods KW - Brain Chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70364573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+magnetic+resonance+imaging+%3A+JMRI&rft.atitle=Regional+apparent+metabolite+concentrations+in+young+adult+brain+measured+by+%281%29H+MR+spectroscopy+at+3+Tesla.&rft.au=Baker%2C+Eva+H%3BBasso%2C+Gianpaolo%3BBarker%2C+Peter+B%3BSmith%2C+Mari+A%3BBonekamp%2C+David%3BHorsk%C3%A1%2C+Alena&rft.aulast=Baker&rft.aufirst=Eva&rft.date=2008-03-01&rft.volume=27&rft.issue=3&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Journal+of+magnetic+resonance+imaging+%3A+JMRI&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.21285 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: NMR Biomed. 2000 May;13(3):129-53 [10861994] Magn Reson Med. 2007 Jun;57(6):983-9 [17534907] AJNR Am J Neuroradiol. 2001 Jan;22(1):128-35 [11158898] Magn Reson Med. 2001 May;45(5):765-9 [11323802] Cereb Cortex. 2001 Jul;11(7):598-605 [11415962] AJNR Am J Neuroradiol. 2001 Oct;22(9):1727-31 [11673168] J Magn Reson Imaging. 2002 Feb;15(2):137-43 [11836768] Magn Reson Med. 2002 Sep;48(3):555-8 [12210925] J Magn Reson Imaging. 2002 Nov;16(5):532-7 [12412029] Magn Reson Med. 2002 Dec;48(6):949-58 [12465103] J Magn Reson Imaging. 2004 Jan;19(1):27-33 [14696217] Pediatr Res. 1999 Oct;46(4):474-85 [10509371] J Magn Reson Imaging. 2004 Nov;20(5):772-8 [15503328] Radiology. 1993 Apr;187(1):219-27 [8451417] NMR Biomed. 1993 Jan-Feb;6(1):89-94 [8384470] Magn Reson Med. 1993 Jun;29(6):804-11 [8350724] Magn Reson Med. 1993 Oct;30(4):424-37 [8255190] Magn Reson Med. 1993 Dec;30(6):672-9 [8139448] J Magn Reson B. 1994 May;104(1):1-10 [8025810] Magn Reson Med. 1994 Aug;32(2):157-63 [7968436] Radiology. 1995 Feb;194(2):483-9 [7529934] Magn Reson Med. 1996 Mar;35(3):356-63 [8699947] NMR Biomed. 1997 Apr;10(2):73-8 [9267864] Magn Reson Med. 1998 Jan;39(1):53-60 [9438437] Magn Reson Imaging. 1998 Nov;16(9):1093-106 [9839993] Magn Reson Med. 1999 Apr;41(4):841-5 [10332862] Neurobiol Aging. 2005 May;26(5):665-72 [15708441] Brain. 2005 May;128(Pt 5):1016-25 [15758036] Magn Reson Med. 2000 Aug;44(2):185-92 [10918316] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jmri.21285 ER - TY - JOUR T1 - Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion. AN - 70363281; 18296647 AB - Inactivation of tumor suppressors is among the rate-limiting steps in carcinogenesis that occur during the tumor promotion stage. The translation inhibitor programmed cell death 4 (Pdcd4) suppresses tumorigenesis and invasion. Although Pdcd4 is not mutationally inactivated in human cancer, the mechanisms controlling Pdcd4 inactivation during tumorigenesis remain elusive. We report that tumor promoter 12-O-tetradecanoylphorbol-13-acetate exposure decreases protein levels of Pdcd4 in mouse skin papillomas and keratinocytes as well as in human HEK293 cells. This decrease is attributable to increased proteasomal degradation of Pdcd4 and is mediated by protein kinase C-dependent activation of phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin-p70(S6K) and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK signaling. Both Akt and p70(S6K) phosphorylate Pdcd4, allowing for binding of the E3-ubiquitin ligase beta-TrCP and consequently ubiquitylation. MEK-ERK signaling on the other hand facilitates the subsequent proteasomal degradation. We further show that Pdcd4 protein levels in vivo are limiting for tumor formation, establishing Pdcd4 as a haploinsufficient tumor suppressor in Pdcd4-deficient mice. Thus, because endogenous Pdcd4 levels are limiting for tumorigenesis, inhibiting signaling to Pdcd4 degradation may prove a valid strategy for cancer prevention and intervention. JF - Cancer research AU - Schmid, Tobias AU - Jansen, Aaron P AU - Baker, Alyson R AU - Hegamyer, Glenn AU - Hagan, John P AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21702, USA. tschmid@ncifcrf.gov Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 1254 EP - 1260 VL - 68 IS - 5 KW - Apoptosis Regulatory Proteins KW - 0 KW - PDCD4 protein, human KW - Pdcd4 protein, mouse KW - RNA-Binding Proteins KW - Ribosomal Protein S6 Kinases, 70-kDa KW - EC 2.7.11.1 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Proteasome Endopeptidase Complex -- metabolism KW - Humans KW - Disease Progression KW - Mice KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Ribosomal Protein S6 Kinases, 70-kDa -- metabolism KW - Mice, Transgenic KW - Signal Transduction KW - Gene Expression Regulation, Neoplastic KW - RNA-Binding Proteins -- metabolism KW - Skin Neoplasms -- chemically induced KW - Apoptosis Regulatory Proteins -- metabolism KW - RNA-Binding Proteins -- physiology KW - Apoptosis Regulatory Proteins -- physiology KW - Skin Neoplasms -- metabolism KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70363281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Translation+inhibitor+Pdcd4+is+targeted+for+degradation+during+tumor+promotion.&rft.au=Schmid%2C+Tobias%3BJansen%2C+Aaron+P%3BBaker%2C+Alyson+R%3BHegamyer%2C+Glenn%3BHagan%2C+John+P%3BColburn%2C+Nancy+H&rft.aulast=Schmid&rft.aufirst=Tobias&rft.date=2008-03-01&rft.volume=68&rft.issue=5&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-07-1719 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-07-1719 ER - TY - JOUR T1 - Genome-wide association for methamphetamine dependence: convergent results from 2 samples. AN - 70362818; 18316681 AB - We can improve understanding of human methamphetamine dependence, and possibly our abilities to prevent and treat this devastating disorder, by identifying genes whose allelic variants predispose to methamphetamine dependence. To find "methamphetamine dependence" genes identified by each of 2 genome-wide association (GWA) studies of independent samples of methamphetamine-dependent individuals and matched controls. Replicated GWA results in each of 2 case-control studies. Japan and Taiwan. Individuals with methamphetamine dependence and matched control subjects free from psychiatric, substance abuse, or substance dependence diagnoses (N = 580). "Methamphetamine dependence" genes that were reproducibly identified by clusters of nominally positive single-nucleotide polymorphisms (SNPs) in both samples in ways that were unlikely to represent chance observations, based on Monte Carlo simulations that corrected for multiple comparisons, and subsets of "methamphetamine dependence" genes that were also identified by GWA studies of dependence on other addictive substances, success in quitting smoking, and memory. Genes identified by clustered nominally positive SNPs from both samples were unlikely to represent chance observations (Monte Carlo P < .00001). Variants in these "methamphetamine dependence" genes are likely to alter cell adhesion, enzymatic functions, transcription, cell structure, and DNA, RNA, and/or protein handling or modification. Cell adhesion genes CSMD1 and CDH13 displayed the largest numbers of clustered nominally positive SNPs. "Methamphetamine dependence" genes overlapped, to extents much greater than chance, with genes identified in GWA studies of dependence on other addictive substances, success in quitting smoking, and memory (Monte Carlo P range < .04 to < .00001). These data support polygenic contributions to methamphetamine dependence from genes that include those whose variants contribute to dependence on several addictive substances, success in quitting smoking, and mnemonic processes. JF - Archives of general psychiatry AU - Uhl, George R AU - Drgon, Tomas AU - Liu, Qing-Rong AU - Johnson, Catherine AU - Walther, Donna AU - Komiyama, Tokutaro AU - Harano, Mutsuo AU - Sekine, Yoshimoto AU - Inada, Toshiya AU - Ozaki, Norio AU - Iyo, Masaomi AU - Iwata, Nakao AU - Yamada, Mitsuhiko AU - Sora, Ichiro AU - Chen, Chih-Ken AU - Liu, Hsing-Cheng AU - Ujike, Hiroshi AU - Lin, Shih-Ku AD - Molecular Neurobiology Branch, National Institutes of Health Intramural Program, Department of Health and Human Services, Baltimore, Maryland 21224, USA. guhl@intra.nida.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 345 EP - 355 VL - 65 IS - 3 KW - CSMD1 protein, human KW - 0 KW - Cadherins KW - H-cadherin KW - Membrane Proteins KW - Methamphetamine KW - 44RAL3456C KW - Abridged Index Medicus KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Adult KW - Case-Control Studies KW - Membrane Proteins -- genetics KW - Genome KW - Cadherins -- genetics KW - Male KW - Female KW - Amphetamine-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Genome-wide+association+for+methamphetamine+dependence%3A+convergent+results+from+2+samples.&rft.au=Uhl%2C+George+R%3BDrgon%2C+Tomas%3BLiu%2C+Qing-Rong%3BJohnson%2C+Catherine%3BWalther%2C+Donna%3BKomiyama%2C+Tokutaro%3BHarano%2C+Mutsuo%3BSekine%2C+Yoshimoto%3BInada%2C+Toshiya%3BOzaki%2C+Norio%3BIyo%2C+Masaomi%3BIwata%2C+Nakao%3BYamada%2C+Mitsuhiko%3BSora%2C+Ichiro%3BChen%2C+Chih-Ken%3BLiu%2C+Hsing-Cheng%3BUjike%2C+Hiroshi%3BLin%2C+Shih-Ku&rft.aulast=Uhl&rft.aufirst=George&rft.date=2008-03-01&rft.volume=65&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=1538-3636&rft_id=info:doi/10.1001%2Farchpsyc.65.3.345 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-24 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archpsyc.65.3.345 ER - TY - JOUR T1 - Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. AN - 70361754; 18316028 AB - Alcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism. Here we report that the steatosis induced in mice by a low-fat, liquid ethanol diet is attenuated by concurrent blockade of cannabinoid CB1 receptors. Global or hepatocyte-specific CB1 knockout mice are resistant to ethanol-induced steatosis and increases in lipogenic gene expression and have increased carnitine palmitoyltransferase 1 activity, which, unlike in controls, is not reduced by ethanol treatment. Ethanol feeding increases the hepatic expression of CB1 receptors and upregulates the endocannabinoid 2-arachidonoylglycerol (2-AG) and its biosynthetic enzyme diacylglycerol lipase beta selectively in hepatic stellate cells. In control but not CB1 receptor-deficient hepatocytes, coculture with stellate cells from ethanol-fed mice results in upregulation of CB1 receptors and lipogenic gene expression. We conclude that paracrine activation of hepatic CB1 receptors by stellate cell-derived 2-AG mediates ethanol-induced steatosis through increasing lipogenesis and decreasing fatty acid oxidation. JF - Cell metabolism AU - Jeong, Won-il AU - Osei-Hyiaman, Douglas AU - Park, Ogyi AU - Liu, Jie AU - Bátkai, Sándor AU - Mukhopadhyay, Partha AU - Horiguchi, Norio AU - Harvey-White, Judith AU - Marsicano, Giovanni AU - Lutz, Beat AU - Gao, Bin AU - Kunos, George AD - Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 227 EP - 235 VL - 7 IS - 3 SN - 1550-4131, 1550-4131 KW - Arachidonic Acids KW - 0 KW - Cannabinoid Receptor Modulators KW - Endocannabinoids KW - Fatty Acids KW - Glycerides KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Srebf1 protein, mouse KW - Sterol Regulatory Element Binding Protein 1 KW - Ethanol KW - 3K9958V90M KW - glyceryl 2-arachidonate KW - 8D239QDW64 KW - Carnitine O-Palmitoyltransferase KW - EC 2.3.1.21 KW - Fatty Acid Synthases KW - EC 2.3.1.85 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Glycerides -- metabolism KW - Animals KW - Carnitine O-Palmitoyltransferase -- metabolism KW - Coculture Techniques KW - Diet, Fat-Restricted KW - Fatty Acid Synthases -- metabolism KW - Disease Models, Animal KW - Mice KW - Arachidonic Acids -- metabolism KW - Mice, Knockout KW - Fatty Acids -- metabolism KW - Piperidines -- pharmacology KW - Oxidation-Reduction KW - Pyrazoles -- pharmacology KW - Sterol Regulatory Element Binding Protein 1 -- metabolism KW - Cells, Cultured KW - Lipoprotein Lipase -- metabolism KW - Mice, Inbred C57BL KW - Up-Regulation KW - Male KW - Hepatocytes -- metabolism KW - Liver -- pathology KW - Liver -- enzymology KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Fatty Liver, Alcoholic -- etiology KW - Fatty Liver, Alcoholic -- metabolism KW - Fatty Liver, Alcoholic -- prevention & control KW - Receptor, Cannabinoid, CB1 -- genetics KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Liver -- metabolism KW - Lipogenesis -- genetics KW - Lipogenesis -- drug effects KW - Cannabinoid Receptor Modulators -- metabolism KW - Liver -- drug effects KW - Fatty Liver, Alcoholic -- pathology KW - Paracrine Communication -- genetics KW - Paracrine Communication -- drug effects KW - Fatty Liver, Alcoholic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70361754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+metabolism&rft.atitle=Paracrine+activation+of+hepatic+CB1+receptors+by+stellate+cell-derived+endocannabinoids+mediates+alcoholic+fatty+liver.&rft.au=Jeong%2C+Won-il%3BOsei-Hyiaman%2C+Douglas%3BPark%2C+Ogyi%3BLiu%2C+Jie%3BB%C3%A1tkai%2C+S%C3%A1ndor%3BMukhopadhyay%2C+Partha%3BHoriguchi%2C+Norio%3BHarvey-White%2C+Judith%3BMarsicano%2C+Giovanni%3BLutz%2C+Beat%3BGao%2C+Bin%3BKunos%2C+George&rft.aulast=Jeong&rft.aufirst=Won-il&rft.date=2008-03-01&rft.volume=7&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Cell+metabolism&rft.issn=15504131&rft_id=info:doi/10.1016%2Fj.cmet.2007.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-29 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Cell Metab. 2008 Mar;7(3):187-8 [18316020] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cmet.2007.12.007 ER - TY - JOUR T1 - A depressed adolescent at high risk of suicidal behavior. AN - 70359483; 18316430 JF - The American journal of psychiatry AU - Vitiello, Benedetto AU - Pearson, Jane L AD - Division of Services and Intervention Research, NIMH, NIH, Bethesda, MD 20892-9633, USA. bvitiell@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 323 EP - 8; quiz 408 VL - 165 IS - 3 SN - 0002-953X, 0002-953X KW - Antidepressive Agents KW - 0 KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Acetaminophen KW - 362O9ITL9D KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Models, Psychological KW - Suicide, Attempted -- psychology KW - Combined Modality Therapy KW - Acetaminophen -- poisoning KW - Humans KW - Antidepressive Agents -- adverse effects KW - Drug Overdose -- psychology KW - Suicide, Attempted -- prevention & control KW - Risk Factors KW - Antidepressive Agents -- therapeutic use KW - Adolescent KW - Male KW - Depressive Disorder, Major -- drug therapy KW - Cognitive Therapy KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depressive Disorder, Major -- psychology KW - Psychology, Adolescent KW - Fluoxetine -- therapeutic use KW - Depressive Disorder, Major -- therapy KW - Suicide -- statistics & numerical data KW - Suicide -- psychology KW - Suicide -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70359483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=A+depressed+adolescent+at+high+risk+of+suicidal+behavior.&rft.au=Vitiello%2C+Benedetto%3BPearson%2C+Jane+L&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2008-03-01&rft.volume=165&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/10.1176%2Fappi.ajp.2007.07101549 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-23 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1176/appi.ajp.2007.07101549 ER - TY - JOUR T1 - Primary chemotherapy with low-dose prolonged infusion gemcitabine and cisplatin in patients with bladder cancer: a Phase II trial. AN - 70357023; 18312930 AB - Gemcitabine is an active agent in the treatment of bladder cancer. The enzyme deoxycytidine kinase catalyzes the phosphorylation of gemcitabine into the active gemcitabine triphosphate. After an infusion during 30 minutes, this enzyme will be saturated, therefore, accumulation of higher intracellular concentrations of the active gemcitabine triphosphate could be achieved by prolonging the infusion time of gemcitabine. Based on previously published Phase I trials, the efficacy and safety of a combination of cisplatin and gemcitabine given as prolonged infusion were tried in a Phase II study of 57 untreated patients with stage III/IV bladder cancer, which is the most common malignant tumor among Egyptian males. Patients received gemcitabine (250 mg/m(2) during 6-hour infusion) on days 1 and 8, and cisplatin (70 mg/m(2)) on day 2 every 21-day cycle. The 41 males and 16 females had a median age of 55 years (range 37-77). A total of 37 patients had transitional cell, 15 had squamous cell, 2 had adenocarcinoma, and 3 had undifferentiated cell carcinoma. The median number of cycles given to these 57 patients was 4 (range 1-6). Of 54 evaluable patients, 5 (9.4%) had complete remission, and 27 (50%) partial remission, for an overall response rate of 59.4%. These results are comparable to those of a previous Phase II study of the same combination but with gemcitabine given in the standard dose and schedule. Responses were observed at all disease sites. Both hematologic and nonhematologic toxicity were treatable and not severe. Prolonged infusion of gemcitabine and cisplatin is an effective treatment for advanced bilharzial-related bladder cancer. Toxicity, especially myelosuppression, is surprisingly mild. This combination deserves to be tried in other different disease categories. JF - Urologic oncology AU - Khaled, Hussein AU - Emara, Mohamed E AU - Gaafar, Rabab M AU - Mansour, Osman AU - Abdel Warith, Ahmed AU - Zaghloul, Mohamed S AU - El Malt, Osama AD - Department of Medical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt. khaled@internetegypt.com PY - 2008 SP - 133 EP - 136 VL - 26 IS - 2 SN - 1078-1439, 1078-1439 KW - Antineoplastic Agents KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Infusions, Intravenous KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Antineoplastic Agents -- administration & dosage KW - Deoxycytidine -- analogs & derivatives KW - Urinary Bladder Neoplasms -- drug therapy KW - Deoxycytidine -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Cisplatin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70357023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urologic+oncology&rft.atitle=Primary+chemotherapy+with+low-dose+prolonged+infusion+gemcitabine+and+cisplatin+in+patients+with+bladder+cancer%3A+a+Phase+II+trial.&rft.au=Khaled%2C+Hussein%3BEmara%2C+Mohamed+E%3BGaafar%2C+Rabab+M%3BMansour%2C+Osman%3BAbdel+Warith%2C+Ahmed%3BZaghloul%2C+Mohamed+S%3BEl+Malt%2C+Osama&rft.aulast=Khaled&rft.aufirst=Hussein&rft.date=2008-03-01&rft.volume=26&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Urologic+oncology&rft.issn=10781439&rft_id=info:doi/10.1016%2Fj.urolonc.2007.01.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-01 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.urolonc.2007.01.013 ER - TY - JOUR T1 - Single-strand DNA-mediated targeted mutagenesis of genomic DNA in early mouse embryos is stimulated by Rad51/54 and by Ku70/86 inhibition. AN - 70355386; 18079752 AB - Low and variable efficiency is a major problem in targeted gene alteration, which is used as a primary tool in gene therapy and animal model studies. We tested several types of constructs alone, or in combination with other factors, to introduce a point mutation into the alphaB-crystallin gene in one-celled mouse embryos. We found that co-injection of ssDNA along with antibodies against Ku70/86, or supplementing the system with hRad51/hRad54, increases efficiency of targeted mutagenesis. These findings suggest that proteins in the homologous recombination DNA repair pathway contribute, and that proteins involved in the alternative nonhomologous end-joining pathway inhibit, ssDNA-mediated targeted mutagenesis. This is the first successful demonstration of targeted mutation in early mouse embryos. This novel methodology of supplying protein factors to stimulate gene modification in the nucleus has not been previously reported. JF - Gene therapy AU - Morozov, V AU - Wawrousek, E F AD - Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, DHHS, Bethesda, MD, USA. morozovv@nei.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 468 EP - 472 VL - 15 IS - 6 KW - Antibodies KW - 0 KW - Antigens, Nuclear KW - DNA, Single-Stranded KW - DNA-Binding Proteins KW - beta-Crystallins KW - Rad51 Recombinase KW - EC 2.7.7.- KW - Xrcc6 protein, human KW - EC 3.6.4.12 KW - Xrcc6 protein, mouse KW - Ku Autoantigen KW - EC 4.2.99.- KW - Index Medicus KW - Animals KW - Antibodies -- administration & dosage KW - Humans KW - Antigens, Nuclear -- immunology KW - Mice KW - Microinjections KW - Genome KW - Polymorphism, Restriction Fragment Length KW - Rad51 Recombinase -- administration & dosage KW - Point Mutation KW - Gene Targeting KW - DNA-Binding Proteins -- immunology KW - Female KW - Cleavage Stage, Ovum -- metabolism KW - beta-Crystallins -- genetics KW - Genetic Therapy -- methods KW - DNA, Single-Stranded -- administration & dosage KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70355386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+therapy&rft.atitle=Single-strand+DNA-mediated+targeted+mutagenesis+of+genomic+DNA+in+early+mouse+embryos+is+stimulated+by+Rad51%2F54+and+by+Ku70%2F86+inhibition.&rft.au=Morozov%2C+V%3BWawrousek%2C+E+F&rft.aulast=Morozov&rft.aufirst=V&rft.date=2008-03-01&rft.volume=15&rft.issue=6&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=Gene+therapy&rft.issn=1476-5462&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. AN - 70355011; 18316609 AB - The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Recently, we have identified that a hepatic stem cell marker, epithelial cell adhesion molecule (EpCAM), may serve as an early biomarker of HCC because its expression is highly elevated in premalignant hepatic tissues and in a subset of HCC. In this study, we aimed to identify novel HCC subtypes that resemble certain stages of liver lineages by searching for EpCAM-coexpressed genes. A unique signature of EpCAM-positive HCCs was identified by cDNA microarray analysis of 40 HCC cases and validated by oligonucleotide microarray analysis of 238 independent HCC cases, which was further confirmed by immunohistochemical analysis of an additional 101 HCC cases. EpCAM-positive HCC displayed a distinct molecular signature with features of hepatic progenitor cells including the presence of known stem/progenitor markers such as cytokeratin 19, c-Kit, EpCAM, and activated Wnt-beta-catenin signaling, whereas EpCAM-negative HCC displayed genes with features of mature hepatocytes. Moreover, EpCAM-positive and EpCAM-negative HCC could be further subclassified into four groups with prognostic implication by determining the level of alpha-fetoprotein (AFP). These four subtypes displayed distinct gene expression patterns with features resembling certain stages of hepatic lineages. Taken together, we proposed an easy classification system defined by EpCAM and AFP to reveal HCC subtypes similar to hepatic cell maturation lineages, which may enable prognostic stratification and assessment of HCC patients with adjuvant therapy and provide new insights into the potential cellular origin of HCC and its activated molecular pathways. JF - Cancer research AU - Yamashita, Taro AU - Forgues, Marshonna AU - Wang, Wei AU - Kim, Jin Woo AU - Ye, Qinghai AU - Jia, Huliang AU - Budhu, Anuradha AU - Zanetti, Krista A AU - Chen, Yidong AU - Qin, Lun-Xiu AU - Tang, Zhao-You AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4258, USA. Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 1451 EP - 1461 VL - 68 IS - 5 KW - Antigens, Neoplasm KW - 0 KW - Biomarkers, Tumor KW - Cell Adhesion Molecules KW - EPCAM protein, human KW - Epithelial Cell Adhesion Molecule KW - alpha-Fetoproteins KW - Index Medicus KW - Gene Expression Profiling KW - Cell Lineage KW - Oligonucleotide Array Sequence Analysis KW - Models, Genetic KW - Humans KW - Prognosis KW - Immunohistochemistry -- methods KW - Cell Line, Tumor KW - Signal Transduction KW - Gene Expression Regulation, Neoplastic KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- diagnosis KW - alpha-Fetoproteins -- biosynthesis KW - Antigens, Neoplasm -- biosynthesis KW - Carcinoma, Hepatocellular -- classification KW - Liver Neoplasms -- diagnosis KW - Cell Adhesion Molecules -- biosynthesis KW - Liver Neoplasms -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70355011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Prevalence%2C+correlates+and+course+of+behavioural+and+psychological+symptoms+of+dementia+in+the+population&rft.au=Savva%2C+George+M.%3BZaccai%2C+Julia%3BMatthews%2C+Fiona+E.%3BDavidson%2C+Julie+E.%3BMcKeith%2C+Ian%3BBrayne%2C+Carol&rft.aulast=Savva&rft.aufirst=George&rft.date=2009-03-01&rft.volume=194&rft.issue=3&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.108.049619 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-07-6013 ER - TY - JOUR T1 - Dietary supplement use in individuals living with cancer and other chronic conditions: a population-based study. AN - 70354585; 18313431 AB - Cancer survivors are increasingly turning to complementary and alternative medicine (CAM) to manage short- and long-term treatment sequelae. Population-based data on relative use of dietary supplements among cancer survivors compared to those without a cancer history is lacking. Our objective was to compare supplement use among those with and without cancer and among those with and without other chronic conditions, and to identify correlates of supplement use by cancer status. Cross-sectional, population-based survey of participants in the 2003 CAM supplement to the 2001 California Health Interview Survey. Participants reporting a cancer diagnosis on the 2001 California Health Interview Survey or newly reported diagnosis on the 2003 survey (n=1,844) plus a random oversampling of racial/ethnic minorities (n=7,343). Self-reported use of a multivitamin and 27 vitamins, minerals, herbs, and other natural products during the preceding 12 months. Logistic regression analyses were performed with control for potential confounders. Adults with cancer or other chronic conditions had higher prevalence of supplement use than those reporting no illness. The independent effect of cancer was associated with vitamin use, whereas living with other chronic conditions was associated with all types of supplement use, except multivitamins. Correlates of supplement use were similar between cancer survivors and cancer-free individuals-being a woman, advancing age, and greater physical activity, fruit and vegetable intake, and other CAM use. Among cancer survivors, non-Hispanic whites had the lowest prevalence of herbal supplement use. These results indicate that having a chronic medical condition is the major factor associated with supplement use. A diagnosis of cancer, by itself, does not have an independent effect on supplement use. This suggests that most supplement use among cancer survivors is directed at dealing with or preventing the exacerbation of a comorbid condition. Consumers and health professionals should be aware that there is limited information on the effects of dietary supplements taken concurrently with prescription and other over-the-counter medications. JF - Journal of the American Dietetic Association AU - Miller, Melissa Farmer AU - Bellizzi, Keith M AU - Sufian, Meryl AU - Ambs, Anita H AU - Goldstein, Michael S AU - Ballard-Barbash, Rachel AD - Cancer Prevention Fellowship Program, National Cancer Institute, 6116 Executive Blvd, Ste 404, MSC 8336, Bethesda, MD 20892, USA. millermeli@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 483 EP - 494 VL - 108 IS - 3 SN - 0002-8223, 0002-8223 KW - Abridged Index Medicus KW - Index Medicus KW - Disease-Free Survival KW - Drug Interactions KW - Educational Status KW - Humans KW - Aged KW - Population Surveillance -- methods KW - Age Distribution KW - California KW - Cross-Sectional Studies KW - Chronic Disease -- prevention & control KW - Logistic Models KW - Adult KW - Health Behavior KW - Middle Aged KW - Sex Distribution KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Complementary Therapies -- utilization KW - Dietary Supplements -- statistics & numerical data KW - Dietary Supplements -- utilization KW - Health Status KW - Complementary Therapies -- statistics & numerical data KW - Neoplasms -- prevention & control KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70354585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dietetic+Association&rft.atitle=Dietary+supplement+use+in+individuals+living+with+cancer+and+other+chronic+conditions%3A+a+population-based+study.&rft.au=Miller%2C+Melissa+Farmer%3BBellizzi%2C+Keith+M%3BSufian%2C+Meryl%3BAmbs%2C+Anita+H%3BGoldstein%2C+Michael+S%3BBallard-Barbash%2C+Rachel&rft.aulast=Miller&rft.aufirst=Melissa&rft.date=2008-03-01&rft.volume=108&rft.issue=3&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dietetic+Association&rft.issn=00028223&rft_id=info:doi/10.1016%2Fj.jada.2007.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-29 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jada.2007.12.005 ER - TY - JOUR T1 - Identification of metastasis-related microRNAs in hepatocellular carcinoma. AN - 70351380; 18176954 AB - MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence. We investigated whether the expression of certain miRNAs are associated with HCC metastasis. We examined the miRNA expression profiles of 482 cancerous and noncancerous specimens from radical resection of 241 patients with HCC. Using a supervised algorithm and a clinically well-defined cohort of 131 cases, we built a unique 20-miRNA metastasis signature that could significantly predict (P < 0.001) primary HCC tissues with venous metastases from metastasis-free solitary tumors with 10-fold cross-validation. However, significant miRNAs could not be identified from the corresponding noncancerous hepatic tissues. A survival risk prediction analysis revealed that a majority of the metastasis-related miRNAs were associated with survival. Furthermore, the 20-miRNA tumor signature was validated in 110 additional cases as a significant independent predictor of survival (P = 0.009) and was significantly associated with both survival and relapse in 89 cases of early stage HCC (P = 0.022 and 0.002, respectively). These 20 miRNAs may provide a simple profiling method to assist in identifying patients with HCC who are likely to develop metastases/recurrence. In addition, functional analysis of these miRNAs may enhance our biological understanding of HCC metastasis. JF - Hepatology (Baltimore, Md.) AU - Budhu, Anuradha AU - Jia, Hu-Liang AU - Forgues, Marshonna AU - Liu, Chang-Gong AU - Goldstein, David AU - Lam, Amy AU - Zanetti, Krista A AU - Ye, Qing-Hai AU - Qin, Lun-Xiu AU - Croce, Carlo M AU - Tang, Zhao-You AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 897 EP - 907 VL - 47 IS - 3 KW - MicroRNAs KW - 0 KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Gene Expression Profiling KW - Aged, 80 and over KW - Humans KW - Adult KW - Prognosis KW - Aged KW - Middle Aged KW - Adolescent KW - Liver Neoplasms -- pathology KW - MicroRNAs -- metabolism KW - Carcinoma, Hepatocellular -- diagnosis KW - MicroRNAs -- genetics KW - Carcinoma, Hepatocellular -- secondary KW - Carcinoma, Hepatocellular -- genetics KW - MicroRNAs -- analysis KW - Liver Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70351380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Identification+of+metastasis-related+microRNAs+in+hepatocellular+carcinoma.&rft.au=Budhu%2C+Anuradha%3BJia%2C+Hu-Liang%3BForgues%2C+Marshonna%3BLiu%2C+Chang-Gong%3BGoldstein%2C+David%3BLam%2C+Amy%3BZanetti%2C+Krista+A%3BYe%2C+Qing-Hai%3BQin%2C+Lun-Xiu%3BCroce%2C+Carlo+M%3BTang%2C+Zhao-You%3BWang%2C+Xin+Wei&rft.aulast=Budhu&rft.aufirst=Anuradha&rft.date=2008-03-01&rft.volume=47&rft.issue=3&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.22160 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-21 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.22160 ER - TY - JOUR T1 - Reduced calcium-dependent mitochondrial damage underlies the reduced vulnerability of excitotoxicity-tolerant hippocampal neurons. AN - 70342168; 18036152 AB - In central neurons, over-stimulation of NMDA receptors leads to excessive mitochondrial calcium accumulation and damage, which is a critical step in excitotoxic death. This raises the possibility that low susceptibility to calcium overload-induced mitochondrial damage might characterize excitotoxicity-resistant neurons. In this study, we have exploited two complementary models of preconditioning-induced excitotoxicity resistance to demonstrate reduced calcium-dependent mitochondrial damage in NMDA-tolerant hippocampal neurons. We have further identified adaptations in mitochondrial calcium handling that account for enhanced mitochondrial integrity. In both models, enhanced tolerance was associated with improved preservation of mitochondrial membrane potential and structure. In the first model, which exhibited modest neuroprotection, mitochondria-dependent calcium deregulation was delayed, even though cytosolic and mitochondrial calcium loads were quantitatively unchanged, indicating that enhanced mitochondrial calcium capacity accounts for reduced injury. In contrast, the second model, which exhibited strong neuroprotection, displayed further delayed calcium deregulation and reduced mitochondrial damage because downregulation of NMDA receptor surface expression depressed calcium loading. Reducing calcium entry also modified the chemical composition of the calcium-buffering precipitates that form in calcium-loaded mitochondria. It thus appears that reduced mitochondrial calcium loading is a major factor underlying the robust neuroprotection seen in highly tolerant cells. JF - Journal of neurochemistry AU - Pivovarova, Natalia B AU - Stanika, Ruslan I AU - Watts, Charlotte A AU - Brantner, Christine A AU - Smith, Carolyn L AU - Andrews, S Brian AD - Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 1686 EP - 1699 VL - 104 IS - 6 KW - Calcium Phosphates KW - 0 KW - Excitatory Amino Acid Agonists KW - Neurotoxins KW - Receptors, N-Methyl-D-Aspartate KW - N-Methylaspartate KW - 6384-92-5 KW - calcium phosphate KW - 97Z1WI3NDX KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Excitatory Amino Acid Agonists -- toxicity KW - Ischemic Preconditioning KW - Pregnancy KW - Rats KW - Down-Regulation -- physiology KW - Adaptation, Physiological -- physiology KW - Cells, Cultured KW - N-Methylaspartate -- toxicity KW - Calcium Phosphates -- metabolism KW - Cell Survival -- physiology KW - Female KW - Calcium -- metabolism KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Neurons -- cytology KW - Hippocampus -- cytology KW - Neurotoxins -- pharmacology KW - Mitochondria -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70342168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Reduced+calcium-dependent+mitochondrial+damage+underlies+the+reduced+vulnerability+of+excitotoxicity-tolerant+hippocampal+neurons.&rft.au=Pivovarova%2C+Natalia+B%3BStanika%2C+Ruslan+I%3BWatts%2C+Charlotte+A%3BBrantner%2C+Christine+A%3BSmith%2C+Carolyn+L%3BAndrews%2C+S+Brian&rft.aulast=Pivovarova&rft.aufirst=Natalia&rft.date=2008-03-01&rft.volume=104&rft.issue=6&rft.spage=1686&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-26 N1 - Date created - 2008-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular characterization of a subgroup specificity associated with the rotavirus inner capsid protein VP2. AN - 70338713; 18216104 AB - Group A rotaviruses are classified into serotypes, based on the reactivity pattern of neutralizing antibodies to VP4 and VP7, as well as into subgroups (SGs), based on non-neutralizing antibodies directed against VP6. The inner capsid protein (VP2) has also been described as a SG antigen; however, little is known regarding the molecular determinants of VP2 SG specificity. In this study, we characterize VP2 SGs by correlating genetic markers with the immunoreactivity of the SG-specific monoclonal antibody (YO-60). Our results show that VP2 proteins similar in sequence to that of the prototypic human strain Wa are recognized by YO-60, classifying them as VP2 SG-II. In contrast, proteins not bound by YO-60 are similar to those of human strains DS-1 or AU-1 and represent VP2 SG-I. Using a mutagenesis approach, we identified residues that determine recognition by either YO-60 or the group A-specific VP2 monoclonal antibody (6E8). We found that YO-60 binds to a conformationally dependent epitope that includes Wa VP2 residue M328. The epitope for 6E8 is also contingent upon VP2 conformation and resides within a single region of the protein (Wa VP2 residues A440 to T530). Using a high-resolution structure of bovine rotavirus double-layered particles, we predicted these epitopes to be spatially distinct from each other and located on opposite surfaces of VP2. This study reveals the extent of genetic variation among group A rotavirus VP2 proteins and illuminates the molecular basis for a previously described SG specificity associated with the rotavirus inner capsid protein. JF - Journal of virology AU - McDonald, Sarah M AU - Patton, John T AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Dr. MSC 8026, Rm. 6314, Bethesda, MD 20892-8026, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 2752 EP - 2764 VL - 82 IS - 6 KW - Antibodies, Monoclonal KW - 0 KW - Capsid Proteins KW - DNA Primers KW - Epitopes KW - VP2 protein, Rotavirus KW - Index Medicus KW - Rotavirus -- classification KW - Phylogeny KW - Animals KW - Genetic Variation KW - Humans KW - Amino Acid Sequence KW - Mutagenesis KW - Antibodies, Monoclonal -- immunology KW - Cloning, Molecular KW - Base Sequence KW - Cells, Cultured KW - Neutralization Tests KW - Molecular Sequence Data KW - Epitopes -- chemistry KW - Rotavirus -- genetics KW - Sequence Homology, Amino Acid KW - Epitopes -- immunology KW - Fluorescent Antibody Technique KW - Capsid Proteins -- immunology KW - Capsid Proteins -- genetics KW - Capsid Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70338713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Molecular+characterization+of+a+subgroup+specificity+associated+with+the+rotavirus+inner+capsid+protein+VP2.&rft.au=McDonald%2C+Sarah+M%3BPatton%2C+John+T&rft.aulast=McDonald&rft.aufirst=Sarah&rft.date=2008-03-01&rft.volume=82&rft.issue=6&rft.spage=2752&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.02492-07 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Apr 27;404(6781):960-7 [10801118] J Virol. 1990 Jan;64(1):411-3 [1688386] Virology. 1994 Oct;204(1):153-62 [7522369] J Gen Virol. 1994 Dec;75 ( Pt 12):3423-30 [7996135] Nature. 1996 Aug 1;382(6590):471-3 [8684490] J Virol. 1996 Nov;70(11):7940-7 [8892917] J Virol. 1997 Oct;71(10):7353-60 [9311813] Virology. 1997 Oct 13;237(1):89-96 [9344910] J Virol. 1997 Dec;71(12):9618-26 [9371626] J Virol. 1998 Jan;72(1):201-8 [9420216] Nature. 1998 Oct 1;395(6701):470-8 [9774103] J Mol Biol. 2006 Feb 10;356(1):209-21 [16359700] Curr Top Microbiol Immunol. 2006;309:189-219 [16913048] J Virol. 2008 Apr;82(7):3204-19 [18216098] Emerg Infect Dis. 2003 May;9(5):565-72 [12737740] J Biol Chem. 2003 Aug 29;278(35):32673-82 [12788926] J Virol. 2004 Jul;78(14):7763-74 [15220450] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Virology. 1981 Jul 30;112(2):385-90 [6266134] Infect Immun. 1981 Aug;33(2):415-25 [6168588] Infect Immun. 1983 Jan;39(1):91-9 [6185436] J Virol. 1984 Jul;51(1):47-51 [6202884] Arch Virol. 1984;81(3-4):193-203 [6089702] J Med Virol. 1984;14(2):115-25 [6092528] Tohoku J Exp Med. 1984 Sep;144(1):105-6 [6095489] Proc Natl Acad Sci U S A. 1985 Dec;82(24):8701-4 [3001716] Arch Virol. 1986;87(1-2):135-41 [3002300] Virology. 1987 Apr;157(2):488-96 [2435059] J Clin Microbiol. 1987 Mar;25(3):509-15 [3033013] J Infect Dis. 1987 Jun;155(6):1159-66 [3033090] J Med Virol. 1988 Jan;24(1):45-53 [2828532] J Clin Microbiol. 1988 Jun;26(6):1238-40 [2838518] Mol Cell Probes. 1989 Sep;3(3):251-61 [2552301] Novartis Found Symp. 2001;238:125-47; discussion 147-52 [11444024] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.02492-07 ER - TY - JOUR T1 - Structural elucidation of critical residues involved in binding of human monoclonal antibodies to hepatitis C virus E2 envelope glycoprotein. AN - 70338669; 18230369 AB - Human monoclonal antibodies derived from B cells of HCV-infected individuals provide information on the immune response to native HCV envelope proteins as they are recognized during infection. Monoclonal antibodies have been useful in the determination of the function and structure of specific immunogenic domains of proteins and should also be useful for the structure/function characterization of HCV E1 and E2 envelope glycoproteins. The HCV E2 envelope glycoprotein has at least three immunodistinctive conformation domains, designated A, B, and C. Conformational epitopes within domain B and C are neutralizing antibody targets on HCV pseudoparticles as well as from infectious cell culture virus. In this study, a combination of differential surface modification and mass spectrometric limited proteolysis followed by alanine mutagenesis was used to provide insight into potential conformational changes within the E2 protein upon antibody binding. The arginine guanidine groups in the E2 protein were modified with CHD in both the affinity bound and free states followed by mass spectrometric analysis, and the regions showing protection upon antibody binding were identified. This protection can arise by direct contact between the residues and the monoclonal antibody, or by antibody-induced conformational changes. Based on the mass spectrometric data, site-directed mutagenesis experiments were performed which clearly identified additional amino acid residues on E2 distant from the site of antibody interaction, whose change to alanine inhibited antibody recognition by inducing conformational changes within the E2 protein. JF - Biochimica et biophysica acta AU - Iacob, Roxana E AU - Keck, Zhenyong AU - Olson, Oakley AU - Foung, Steven K H AU - Tomer, Kenneth B AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 530 EP - 542 VL - 1784 IS - 3 SN - 0006-3002, 0006-3002 KW - Antibodies, Monoclonal KW - 0 KW - Antigen-Antibody Complex KW - Hepatitis C Antibodies KW - Immunodominant Epitopes KW - Viral Envelope Proteins KW - glycoprotein E2, Hepatitis C virus KW - 157184-61-7 KW - Arginine KW - 94ZLA3W45F KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Arginine -- genetics KW - Arginine -- chemistry KW - Humans KW - Molecular Sequence Data KW - Hepatitis C Antibodies -- immunology KW - Amino Acid Sequence KW - Epitope Mapping KW - Protein Conformation KW - Antibodies, Monoclonal -- immunology KW - Immunodominant Epitopes -- immunology KW - Antigen-Antibody Reactions KW - Antigen-Antibody Complex -- immunology KW - Viral Envelope Proteins -- immunology KW - Viral Envelope Proteins -- chemistry KW - Immunodominant Epitopes -- genetics KW - Immunodominant Epitopes -- chemistry KW - Antigen-Antibody Complex -- chemistry KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70338669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Structural+elucidation+of+critical+residues+involved+in+binding+of+human+monoclonal+antibodies+to+hepatitis+C+virus+E2+envelope+glycoprotein.&rft.au=Iacob%2C+Roxana+E%3BKeck%2C+Zhenyong%3BOlson%2C+Oakley%3BFoung%2C+Steven+K+H%3BTomer%2C+Kenneth+B&rft.aulast=Iacob&rft.aufirst=Roxana&rft.date=2008-03-01&rft.volume=1784&rft.issue=3&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbapap.2007.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-15 N1 - Date created - 2008-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Biotechnol. 2002 Jan;20(1):49-62 [11876299] J Virol. 2002 Aug;76(15):7672-82 [12097581] J Exp Med. 2003 Mar 3;197(5):633-42 [12615904] Nature. 2003 Mar 20;422(6929):307-12 [12646921] Virology. 2003 Mar 15;307(2):255-65 [12667795] Biochimie. 2003 Mar-Apr;85(3-4):295-301 [12770768] J Biol Chem. 2003 Nov 7;278(45):44385-92 [12882983] J Virol. 2004 Mar;78(6):2994-3002 [14990718] J Virol. 2004 Jul;78(13):7257-63 [15194801] J Virol. 2004 Sep;78(17):9224-32 [15308717] J Gen Virol. 2004 Nov;85(Pt 11):3173-88 [15483230] Annu Rev Microbiol. 2004;58:391-424 [15487943] Biomed Mass Spectrom. 1984 Nov;11(11):601 [6525415] Science. 1989 Oct 6;246(4926):64-71 [2675315] Anal Chem. 1990 May 1;62(9):882-99 [2194402] Proc Natl Acad Sci U S A. 1990 Dec;87(24):9848-52 [1702219] Anal Biochem. 1991 Jul;196(1):120-5 [1888025] Anal Chem. 1991 Dec 15;63(24):1193A-1203A [1789447] Virology. 1992 Apr;187(2):573-90 [1312269] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5630-4 [1608973] J Virol. 1993 May;67(5):2747-55 [8474172] Bioconjug Chem. 1994 Nov-Dec;5(6):583-90 [7873661] Nature. 1995 May 25;375(6529):291-8 [7753193] J Immunol. 1996 Jul 1;157(1):198-206 [8683115] J Virol. 1997 Feb;71(2):1443-52 [8995670] Virology. 1997 Apr 28;231(1):119-29 [9143310] J Virol. 1997 Nov;71(11):8377-84 [9343193] J Cell Biol. 1997 Nov 3;139(3):613-23 [9348279] J Viral Hepat. 1997;4(6):421-2 [9430363] Nature. 1998 Jun 18;393(6686):705-11 [9641684] Virology. 1998 Sep 15;249(1):32-41 [9740774] J Biol Chem. 1998 Nov 27;273(48):32088-95 [9822684] J Virol. 2005 Jan;79(2):1252-61 [15613352] Nat Rev Immunol. 2005 Mar;5(3):215-29 [15738952] J Virol. 2005 Apr;79(8):4870-6 [15795272] Nature. 2005 Aug 18;436(7053):946-52 [16107834] J Virol. 2005 Nov;79(21):13199-208 [16227243] Mass Spectrom Rev. 2006 Jul-Aug;25(4):663-82 [16477643] J Virol. 2006 Sep;80(17):8695-704 [16912317] Hepatology. 2006 Nov;44(5):1355-61 [17058236] J Am Soc Mass Spectrom. 2006 Nov;17(11):1560-9 [16875837] J Virol. 2007 Jan;81(2):1043-7 [17079294] J Virol. 2007 Feb;81(4):2031-8 [17108020] Novartis Found Symp. 2006;277:57-65; discussion 65-73, 251-3 [17319154] Science. 2000 Apr 14;288(5464):339-44 [10764648] J Immunol. 2000 Apr 15;164(8):4156-61 [10754311] J Virol. 2007 Aug;81(15):8101-11 [17522218] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5802-6 [10811876] Proteins. 2000 Aug 15;40(3):355-66 [10861927] J Gen Virol. 2000 Oct;81(Pt 10):2451-9 [10993933] J Virol. 2000 Nov;74(22):10407-16 [11044085] Anal Chem. 2001 Aug 15;73(16):4012-9 [11534730] Trends Biochem Sci. 2001 Nov;26(11):687-9 [11701329] Immunity. 2001 Dec;15(6):883-95 [11754811] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbapap.2007.12.015 ER - TY - JOUR T1 - Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. AN - 70320510; 17713474 AB - Polypharmacy, common in older people, confers both risk of adverse outcomes and benefits. We assessed the relationship of commonly prescribed medications with anticholinergic and sedative effects to physical and cognitive performance in older individuals. The study population comprised 932 moderately to severely disabled community-resident women aged 65 years or older who were participants in the Women's Health and Aging Study I. A scale based on pharmacodynamic principles was developed and utilized as a measure of drug burden. This was related to measures of physical and cognitive function. After adjusting for demographics and comorbidities, anticholinergic drug burden was independently associated with greater difficulty in four physical function domains with adjusted odds ratios (95% confidence interval (CI)) of 4.9 (2.0-12.0) for balance difficulty; 3.2 (1.5-6.9) for mobility difficulty; 3.6 (1.6-8.0) for slow gait; 4.2 (2.0-8.7) for chair stands difficulty; 2.4 (1.1-5.3) for weak grip strength; 2.7 (1.3-5.4) for upper extremity limitations; 3.4 (1.7-6.9) for difficulty in activities of daily living; and 2.4 (95% CI, 1.1-5.1) for poor performance on the Mini-Mental State Examination. Sedative burden was associated only with impaired grip strength (3.3 (1.5-7.3)) and mobility difficulty (2.4 (1.1-5.3)). The burden of multiple drugs can be quantified by incorporating the recommended dose regimen and the actual dose and frequency of drug taken. Anticholinergic drug burden is strongly associated with limitations in physical and cognitive function. Sedative burden is associated with impaired functioning in more limited domains. The risk associated with exposure of vulnerable older women to drugs with anticholinergic properties, and to a lesser extent those with sedative properties, implies that such drugs should not be used in this patient group without compelling clinical indication. JF - Clinical pharmacology and therapeutics AU - Cao, Y-J AU - Mager, D E AU - Simonsick, E M AU - Hilmer, S N AU - Ling, S M AU - Windham, B G AU - Crentsil, V AU - Yasar, S AU - Fried, L P AU - Abernethy, D R AD - National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 422 EP - 429 VL - 83 IS - 3 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Cholinergic Antagonists KW - Hypnotics and Sedatives KW - Abridged Index Medicus KW - Index Medicus KW - Cross-Sectional Studies KW - Cognition Disorders -- diagnosis KW - Aged, 80 and over KW - Humans KW - Aged KW - Cognition Disorders -- chemically induced KW - Residence Characteristics KW - Female KW - Cognition Disorders -- psychology KW - Cognition -- physiology KW - Cognition -- drug effects KW - Movement -- physiology KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Polypharmacy KW - Cholinergic Antagonists -- pharmacology KW - Hypnotics and Sedatives -- adverse effects KW - Cholinergic Antagonists -- adverse effects KW - Hypnotics and Sedatives -- pharmacology KW - Angiotensin-Converting Enzyme Inhibitors -- pharmacology KW - Movement -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70320510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Physical+and+cognitive+performance+and+burden+of+anticholinergics%2C+sedatives%2C+and+ACE+inhibitors+in+older+women.&rft.au=Cao%2C+Y-J%3BMager%2C+D+E%3BSimonsick%2C+E+M%3BHilmer%2C+S+N%3BLing%2C+S+M%3BWindham%2C+B+G%3BCrentsil%2C+V%3BYasar%2C+S%3BFried%2C+L+P%3BAbernethy%2C+D+R&rft.aulast=Cao&rft.aufirst=Y-J&rft.date=2008-03-01&rft.volume=83&rft.issue=3&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-13 N1 - Date created - 2008-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. AN - 70313096; 17592478 AB - Women who have experienced childhood sexual abuse (CSA) have an increased risk of alcoholism and antisocial personality disorder (ASPD). Among male subjects, a functional polymorphism (MAOA-LPR, monoamine oxidase A linked polymorphic region) in the promoter region of the monoamine oxidase A gene (MAOA) appears to moderate the effect of childhood maltreatment on antisocial behavior. Our aim was to test whether MAOA-LPR influences the impact of CSA on alcoholism and ASPD in a sample of 291 women, 50% of whom have experienced CSA; we also tested whether haplotypes covering the region where both MAOA and monoamine oxidase B (MAOB) genes are located predict risk of alcoholism and ASPD better than the MAOA-LPR locus alone. Participants included 168 alcoholics (39 with ASPD (antisocial alcoholics) and 123 controls (no alcoholics, no ASPD). Antisocial behavior was also modeled as a continuous trait: ASPD symptoms count. The MAOA-LPR low activity allele was associated with alcoholism (P=0.005), particularly antisocial alcoholism (P=0.00009), only among sexually abused subjects. Sexually abused women who were homozygous for the low activity allele had higher rates of alcoholism and ASPD, and more ASPD symptoms, than abused women homozygous for the high activity allele. Heterozygous women displayed an intermediate risk pattern. In contrast, there was no relationship between alcoholism/antisocial behavior and MAOA-LPR genotype among non-abused women. The MAOA-LPR low activity allele was found on three different haplotypes. The most abundant MAOA haplotype containing the MAOA-LPR low activity allele was found in excess among alcoholics (P=0.008) and antisocial alcoholics (P=0.001). Finally, a MAOB haplotype, which we termed haplotype C, was significantly associated with alcoholism (P=0.006), and to a lesser extent with antisocial alcoholism (P=0.03). In conclusions, MAOA seems to moderate the impact of childhood trauma on adult psychopathology in female subjects in the same way as previously shown among male subjects. The MAOA-LPR low activity allele appears to confer increased vulnerability to the adverse psychosocial consequences of CSA. Haplotype-based analysis of the MAOA gene appeared to strengthen the association, as compared to the MAOA-LPR locus alone. A MAOB haplotype was associated with alcoholism independently from ASPD. JF - Molecular psychiatry AU - Ducci, F AU - Enoch, M-A AU - Hodgkinson, C AU - Xu, K AU - Catena, M AU - Robin, R W AU - Goldman, D AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852, USA. duccif@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 334 EP - 347 VL - 13 IS - 3 KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Index Medicus KW - Analysis of Variance KW - Gene Frequency KW - Humans KW - Interpersonal Relations KW - Child KW - Genotype KW - Indians, North American KW - Adult KW - Middle Aged KW - Genetic Predisposition to Disease KW - Polymorphism, Single Nucleotide -- genetics KW - Diagnostic and Statistical Manual of Mental Disorders KW - Male KW - Child Abuse, Sexual -- psychology KW - Alcoholism -- etiology KW - Antisocial Personality Disorder -- genetics KW - Antisocial Personality Disorder -- psychology KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Monoamine Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70313096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+psychiatry&rft.atitle=Interaction+between+a+functional+MAOA+locus+and+childhood+sexual+abuse+predicts+alcoholism+and+antisocial+personality+disorder+in+adult+women.&rft.au=Ducci%2C+F%3BEnoch%2C+M-A%3BHodgkinson%2C+C%3BXu%2C+K%3BCatena%2C+M%3BRobin%2C+R+W%3BGoldman%2C+D&rft.aulast=Ducci&rft.aufirst=F&rft.date=2008-03-01&rft.volume=13&rft.issue=3&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Molecular+psychiatry&rft.issn=1476-5578&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-17 N1 - Date created - 2008-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cooperative damage recognition by UvrA and UvrB: identification of UvrA residues that mediate DNA binding. AN - 70305805; 18248777 AB - Nucleotide excision repair (NER) is responsible for the recognition and removal of numerous structurally unrelated DNA lesions. In prokaryotes, the proteins UvrA, UvrB and UvrC orchestrate the recognition and excision of aberrant lesions from DNA. Despite the progress we have made in understanding the NER pathway, it remains unclear how the UvrA dimer interacts with DNA to facilitate DNA damage recognition. The purpose of this study was to define amino acid residues in UvrA that provide binding energy to DNA. Based on conservation among approximately 300 UvrA sequences and 3D-modeling, two positively charged residues, Lys680 and Arg691, were predicted to be important for DNA binding. Mutagenesis and biochemical analysis of Bacillus caldontenax UvrA variant proteins containing site directed mutations at these residues demonstrate that Lys680 and Arg691 make a significant contribution toward the DNA binding affinity of UvrA. Replacing these side chains with alanine or negatively charged residues decreased UvrA binding 3-37-fold. Survival studies indicated that these mutant proteins complemented a WP2 uvrA(-) strain of bacteria 10-100% of WT UvrA levels. Further analysis by DNase I footprinting of the double UvrA mutant revealed that the UvrA DNA binding defects caused a slower rate of transfer of DNA to UvrB. Consequently, the mutants initiated the oligonucleotide incision assay nearly as well as WT UvrA thus explaining the observed mild phenotype in the survival assay. Based on our findings we propose a model of how UvrA binds to DNA. JF - DNA repair AU - Croteau, Deborah L AU - DellaVecchia, Matthew J AU - Perera, Lalith AU - Van Houten, Bennett AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 392 EP - 404 VL - 7 IS - 3 SN - 1568-7864, 1568-7864 KW - DNA, Bacterial KW - 0 KW - DNA-Binding Proteins KW - Escherichia coli Proteins KW - UvrB protein, E coli KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - UvrA protein, E coli KW - EC 3.6.1- KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - DNA Repair KW - Models, Molecular KW - DNA Footprinting KW - Electrophoretic Mobility Shift Assay KW - Adenosine Triphosphate -- metabolism KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - DNA Damage -- radiation effects KW - Protein Conformation KW - Escherichia coli Proteins -- metabolism KW - DNA Helicases -- metabolism KW - DNA, Bacterial -- genetics KW - DNA-Binding Proteins -- genetics KW - DNA Helicases -- genetics KW - Adenosine Triphosphatases -- metabolism KW - DNA, Bacterial -- metabolism KW - Adenosine Triphosphatases -- genetics KW - Escherichia coli Proteins -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70305805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Staging+dementia+from+symptom+profiles+on+a+care+partner+website&rft.au=Rockwood%2C+Kenneth%3BRichard%2C+Matthew%3BLeibman%2C+Chris%3BMucha%2C+Lisa%3BMitnitski%2C+Arnold&rft.aulast=Rockwood&rft.aufirst=Kenneth&rft.date=2013-08-01&rft.volume=15&rft.issue=8&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=1438-8871&rft_id=info:doi/10.2196%2Fjmir.2461 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-24 N1 - Date created - 2008-02-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 1999 Nov 16;38(46):15116-28 [10563794] EMBO J. 2007 Jan 24;26(2):613-22 [17245438] EMBO J. 1999 Dec 15;18(24):6899-907 [10601012] J Biol Chem. 2000 Feb 18;275(7):5120-3 [10671556] J Biol Chem. 2000 Mar 17;275(11):8038-43 [10713124] J Biol Chem. 2000 Mar 17;275(11):8044-50 [10713125] Cell. 2000 Jun 23;101(7):789-800 [10892749] J Bacteriol. 2000 Oct;182(20):5706-14 [11004168] EMBO J. 2001 Nov 1;20(21):6140-9 [11689453] J Biol Chem. 2002 Jan 11;277(2):1553-9 [11687584] EMBO J. 2002 Aug 1;21(15):4196-205 [12145219] Structure. 2003 Dec;11(12):1475-83 [14656432] EMBO J. 2004 Jul 7;23(13):2498-509 [15192705] Nucleic Acids Res. 1985 Mar 11;13(5):1483-92 [2987825] Proc Natl Acad Sci U S A. 1985 Aug;82(15):4925-9 [3161077] Proc Natl Acad Sci U S A. 1985 Oct;82(20):6774-8 [2931721] J Biol Chem. 1986 Apr 15;261(11):4895-901 [3007478] J Biol Chem. 1987 Sep 25;262(27):13180-7 [3308871] Nucleic Acids Res. 1988 Nov 25;16(22):10891-902 [2974538] J Biol Chem. 1989 Mar 25;264(9):5172-6 [2538476] J Biol Chem. 1990 Sep 15;265(26):15796-803 [2168423] Biochemistry. 1991 Apr 23;30(16):3824-34 [1826850] Biochemistry. 1991 Apr 23;30(16):3834-40 [1826851] Biochemistry. 1991 May 7;30(18):4432-43 [1827034] J Biol Chem. 1991 Jun 15;266(17):11380-7 [1645734] J Biol Chem. 1991 Jun 15;266(17):11388-94 [1828248] J Biol Chem. 1991 Jun 15;266(17):11395-403 [1828249] J Mol Biol. 1991 Jul 5;220(1):19-33 [2067017] J Biol Chem. 1992 Sep 5;267(25):17688-92 [1387639] Science. 1993 Mar 5;259(5100):1415-20 [8451638] Mutat Res. 1993 Oct;294(3):263-74 [7692266] J Biol Chem. 1994 Apr 8;269(14):10771-5 [8144665] J Biol Chem. 1995 Dec 22;270(51):30508-15 [8530482] Biochemistry. 1998 May 26;37(21):7733-40 [9601033] Nat Struct Biol. 1998 Aug;5(8):701-6 [9699634] Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11717-22 [10518516] EMBO J. 2005 Mar 9;24(5):885-94 [15692561] DNA Repair (Amst). 2005 Jun 8;4(6):699-713 [15886069] Mutat Res. 2005 Sep 4;577(1-2):92-117 [15927210] Chem Rev. 2006 Feb;106(2):233-52 [16464004] Nat Struct Mol Biol. 2006 Mar;13(3):278-84 [16491090] J Mol Biol. 2006 Mar 17;357(1):62-72 [16426634] Nat Struct Mol Biol. 2006 Apr;13(4):360-4 [16532007] J Biol Chem. 2006 Jun 2;281(22):15227-37 [16595666] J Biol Chem. 2006 Sep 8;281(36):26370-81 [16829526] FEBS Lett. 2006 Nov 27;580(27):6423-7 [17097086] J Biochem. 1999 Dec;126(6):986-90 [10578047] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2007.11.013 ER - TY - JOUR T1 - Molecular characterization of feline immunodeficiency virus budding. AN - 70296496; 18094166 AB - Infection of domestic cats with feline immunodeficiency virus (FIV) is an important model system for studying human immunodeficiency virus type 1 (HIV-1) infection due to numerous similarities in pathogenesis induced by these two lentiviruses. However, many molecular aspects of FIV replication remain poorly understood. It is well established that retroviruses use short peptide motifs in Gag, known as late domains, to usurp cellular endosomal sorting machinery and promote virus release from infected cells. For example, the Pro-Thr/Ser-Ala-Pro [P(T/S)AP] motif of HIV-1 Gag interacts directly with Tsg101, a component of the endosomal sorting complex required for transport I (ESCRT-I). A Tyr-Pro-Asp-Leu (YPDL) motif in equine infectious anemia virus (EIAV), and a related sequence in HIV-1, bind the endosomal sorting factor Alix. In this study we sought to identify and characterize FIV late domain(s) and elucidate cellular machinery involved in FIV release. We determined that mutagenesis of a PSAP motif in FIV Gag, small interfering RNA-mediated knockdown of Tsg101 expression, and overexpression of a P(T/S)AP-binding fragment of Tsg101 (TSG-5') each inhibited FIV release. We also observed direct binding of FIV Gag peptides to Tsg101. In contrast, mutagenesis of a potential Alix-binding motif in FIV Gag did not affect FIV release. Similarly, expression of the HIV-1/EIAV Gag-binding domain of Alix (Alix-V) did not disrupt FIV budding, and FIV Gag peptides showed no affinity for Alix-V. Our data demonstrate that FIV relies predominantly on a Tsg101-binding PSAP motif in the C terminus of Gag to promote virus release in HeLa cells, and this budding mechanism is highly conserved in feline cells. JF - Journal of virology AU - Luttge, Benjamin G AU - Shehu-Xhilaga, Miranda AU - Demirov, Dimiter G AU - Adamson, Catherine S AU - Soheilian, Ferri AU - Nagashima, Kunio AU - Stephen, Andrew G AU - Fisher, Robert J AU - Freed, Eric O AD - Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Bldg. 535, Rm. 108, Frederick, MD 21702-1201, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 2106 EP - 2119 VL - 82 IS - 5 KW - DNA Primers KW - 0 KW - Gene Products, gag KW - RNA, Small Interfering KW - Index Medicus KW - Virus Replication KW - Animals KW - Gene Products, gag -- physiology KW - HeLa Cells KW - Humans KW - Amino Acid Sequence KW - Gene Products, gag -- chemistry KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Conserved Sequence KW - Cats KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Fluorescent Antibody Technique KW - Cell Line KW - Immunodeficiency Virus, Feline -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70296496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Molecular+characterization+of+feline+immunodeficiency+virus+budding.&rft.au=Luttge%2C+Benjamin+G%3BShehu-Xhilaga%2C+Miranda%3BDemirov%2C+Dimiter+G%3BAdamson%2C+Catherine+S%3BSoheilian%2C+Ferri%3BNagashima%2C+Kunio%3BStephen%2C+Andrew+G%3BFisher%2C+Robert+J%3BFreed%2C+Eric+O&rft.aulast=Luttge&rft.aufirst=Benjamin&rft.date=2008-03-01&rft.volume=82&rft.issue=5&rft.spage=2106&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 1985 Nov;43(1):223-31 [3878228] J Virol. 1986 Aug;59(2):284-91 [3016298] Science. 1987 Feb 13;235(4790):790-3 [3643650] J Virol. 1988 Jan;62(1):139-47 [3257102] AIDS Res Hum Retroviruses. 1987 Fall;3(3):253-64 [3481270] Am J Vet Res. 1988 Aug;49(8):1246-58 [2459996] Proc Natl Acad Sci U S A. 1988 Dec;85(24):9580-4 [2849111] J Cell Biol. 2005 Jan 3;168(1):89-101 [15623582] J Virol. 2005 Mar;79(6):3775-86 [15731271] Mol Ther. 2005 Jul;12(1):137-43 [15963929] J Cell Sci. 2005 Jul 15;118(Pt 14):3003-17 [16014378] Blood. 2005 Sep 1;106(5):1552-8 [15886327] J Virol. 1995 Sep;69(9):5455-60 [7636991] J Virol. 1995 Nov;69(11):6810-8 [7474093] Virology. 1996 Jan 1;215(1):10-6 [8553580] J Virol. 1997 Sep;71(9):6541-6 [9261374] Nat Med. 1998 Mar;4(3):354-7 [9500613] J Virol. 1998 May;72(5):4095-103 [9557699] EMBO J. 1998 Jun 1;17(11):2982-93 [9606181] Virology. 1998 Nov 10;251(1):1-15 [9813197] Protein Expr Purif. 1999 Feb;15(1):34-9 [10024467] EMBO J. 1999 Sep 1;18(17):4700-10 [10469649] Virus Res. 2004 Dec;106(2):87-102 [15567490] J Biol Chem. 2001 Apr 13;276(15):11735-42 [11134028] Virus Res. 2001 Jul;76(1):103-13 [11376850] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7724-9 [11427703] Cell. 2001 Jul 27;106(2):145-55 [11511343] Cell. 2001 Oct 5;107(1):55-65 [11595185] Nat Med. 2001 Dec;7(12):1313-9 [11726971] J Virol. 2002 Jan;76(1):105-17 [11739676] Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):955-60 [11805336] J Virol. 2002 Mar;76(6):2641-7 [11861830] J Cell Biol. 2002 Apr 1;157(1):91-101 [11916981] EMBO J. 2002 May 15;21(10):2397-406 [12006492] J Virol. 2002 Jun;76(12):6311-22 [12021364] Dev Cell. 2002 Aug;3(2):271-82 [12194857] Dev Cell. 2002 Aug;3(2):283-9 [12194858] J Virol. 2002 Oct;76(19):10024-9 [12208980] Curr Protein Pept Sci. 2001 Dec;2(4):381-8 [12374097] Nat Struct Biol. 2002 Nov;9(11):812-7 [12379843] J Virol. 2003 Apr;77(8):4794-804 [12663786] J Biol Chem. 2005 Dec 9;280(49):40474-80 [16215227] Virology. 2006 Jan 5;344(1):55-63 [16364736] Curr HIV Res. 2006 Jul;4(3):293-305 [16842082] J Wildl Dis. 2006 Apr;42(2):234-48 [16870846] J Virol. 2006 Aug;80(16):7832-43 [16873240] J Virol. 2006 Oct;80(19):9371-80 [16973543] Org Lett. 2006 Oct 26;8(22):5165-8 [17048869] Genomics. 2007 Feb;89(2):189-96 [16997530] J Biol Chem. 2007 Feb 9;282(6):3847-55 [17158451] Nat Struct Mol Biol. 2007 Mar;14(3):194-9 [17277784] Cell. 2007 Mar 9;128(5):841-52 [17350572] Comp Immunol Microbiol Infect Dis. 2008 Mar;31(2-3):167-90 [17706778] J Virol. 1990 Oct;64(10):4605-13 [1697907] Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3195-9 [2014240] J Virol. 1993 Apr;67(4):1869-76 [8383214] J Virol. 1994 Aug;68(8):5311-20 [8035531] J Virol. 1994 Oct;68(10):6605-18 [8083996] C R Acad Sci III. 1994 Dec;317(12):1123-34 [7697467] J Virol. 2003 Jun;77(11):6507-19 [12743307] Curr Opin Cell Biol. 2003 Aug;15(4):446-55 [12892785] J Cell Biol. 2003 Aug 4;162(3):435-42 [12900395] Cell. 2003 Sep 19;114(6):689-99 [14505569] Cell. 2003 Sep 19;114(6):701-13 [14505570] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12414-9 [14519844] J Virol. 2003 Nov;77(22):11882-95 [14581525] J Virol. 2004 Jan;78(2):724-32 [14694104] J Virol. 2004 Feb;78(3):1503-12 [14722305] Front Biosci. 2004 Jan 1;9:370-7 [14766374] J Gene Med. 2004 Feb;6 Suppl 1:S95-104 [14978754] Curr HIV Res. 2003 Jan;1(1):15-29 [15043209] Mol Vis. 2004 Apr 13;10:272-80 [15094709] J Virol. 2004 Jun;78(12):6636-48 [15163754] J Biol Chem. 2004 Aug 20;279(34):36059-71 [15218037] Virology. 2004 Sep 15;327(1):83-92 [15327900] Annu Rev Cell Dev Biol. 2004;20:395-425 [15473846] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York. AN - 70294502; 17624591 AB - p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function. We evaluated whether three well-characterized TP53 variants -- Ex4 + 119 C > G (rs#1042522, Arg72Pro), IVS6 + 62 A > G (rs#1625895), and an IVS3 16 bp insertion/ deletion (INDEL; rs#17878362) -- were associated with breast cancer risk in a population-based case-control study. Genotypes and haplotypes were determined using long-range PCR in a sample of 578 cases and 390 controls. For the Ex4 + 19 C > G SNP (rs1042522), women with the heterozygous genotype (G/C) had a 32% increase in breast cancer risk. Other variants were not associated with risk. We further examined whether these associations were modified by cigarette smoking status and detection of PAH-DNA adducts in circulating lymphocytes. Among current smokers, each copy of the minor alleles for the IVS6 + 62 A > G SNP (rs1625895) and the IVS3 INDEL polymorphism (rs17878362) was associated with lower breast cancer risk (OR = 0.49, 95% CI 0.27-0.90; OR = 0.42, 95% CI 0.22-0.78, respectively). However, among former smokers, the homozygous variant genotype for these 2 SNPs was observed among cases (4.1 and 3.2%, respectively) and not controls. Genotype associations were not modified by the presence or absence of DNA adducts in circulating lymphocytes. Three-loci haplotypes were not significantly associated with breast cancer risk. These results should be confirmed in larger studies, but suggest that cigarette smoking may influence breast cancer risk through interaction with p53. JF - Breast cancer research and treatment AU - Gaudet, Mia M AU - Gammon, Marilie D AU - Bensen, Jeannette T AU - Sagiv, Sharon K AU - Shantakumar, Sumitra AU - Teitelbaum, Susan L AU - Eng, Sybil M AU - Neugut, Alfred I AU - Santella, Regina M AD - Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA, gaudetm@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 93 EP - 99 VL - 108 IS - 1 SN - 0167-6806, 0167-6806 KW - DNA Adducts KW - 0 KW - Polycyclic Aromatic Hydrocarbons KW - Tumor Suppressor Protein p53 KW - polycyclic aromatic hydrocarbons-DNA adduct KW - Index Medicus KW - Genotype KW - DNA Adducts -- blood KW - Polymerase Chain Reaction KW - New York KW - Haplotypes KW - Risk Factors KW - Humans KW - Middle Aged KW - Female KW - Breast Neoplasms -- genetics KW - Polycyclic Aromatic Hydrocarbons -- blood KW - Smoking -- adverse effects KW - Polycyclic Aromatic Hydrocarbons -- adverse effects KW - Genetic Predisposition to Disease KW - Tumor Suppressor Protein p53 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70294502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Genetic+variation+of+TP53%2C+polycyclic+aromatic+hydrocarbon-related+exposures%2C+and+breast+cancer+risk+among+women+on+Long+Island%2C+New+York.&rft.au=Gaudet%2C+Mia+M%3BGammon%2C+Marilie+D%3BBensen%2C+Jeannette+T%3BSagiv%2C+Sharon+K%3BShantakumar%2C+Sumitra%3BTeitelbaum%2C+Susan+L%3BEng%2C+Sybil+M%3BNeugut%2C+Alfred+I%3BSantella%2C+Regina+M&rft.aulast=Gaudet&rft.aufirst=Mia&rft.date=2008-03-01&rft.volume=108&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-20 N1 - Date created - 2008-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of protein kinase C modulates BACE1-mediated beta-secretase activity. AN - 70292972; 17157415 AB - beta-Site APP cleavage enzyme 1 (BACE1) is the beta-secretase responsible for generating amyloid-beta (A beta) peptides in Alzheimer's disease (AD). Previous studies suggest that activation of protein kinase C (PKC) modulates the beta-secretase-mediated cleavage of APP and reduces the production of A beta. The mechanism of PKC-mediated modulation of beta-secretase activity, however, remains elusive. We report here that activation of PKC modulated beta-secretase activity through either suppressing the accumulation or promoting the translocation of BACE1 protein in a cell type-dependent manner. We found that activation of PKC suppressed the accumulation of BACE1 protein in fibroblasts through an enhancement of intracellular protease activities. In neurons, activation of PKC did not alter the expression level of BACE1, but led to more BACE1 translocated to the cell surface, resulting in a decreased cleavage of APP at the beta1 site. Together, Our findings provide novel mechanisms of PKC-mediated modulation of beta-secretase activity, suggesting that alteration of the intracellular trafficking of BACE1 may serve as a useful therapeutic strategy to lower the production of A beta in AD. JF - Neurobiology of aging AU - Wang, Lizhen AU - Shim, Hoon AU - Xie, Chengsong AU - Cai, Huaibin AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 357 EP - 367 VL - 29 IS - 3 KW - Amyloid beta-Peptides KW - 0 KW - Enzyme Inhibitors KW - Protein Kinase C KW - EC 2.7.11.13 KW - Amyloid Precursor Protein Secretases KW - EC 3.4.- KW - Aspartic Acid Endopeptidases KW - EC 3.4.23.- KW - Bace1 protein, mouse KW - EC 3.4.23.46 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Fibroblasts -- drug effects KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Neurons -- drug effects KW - Mice KW - Phosphorylation -- drug effects KW - Mice, Knockout KW - Transfection -- methods KW - Animals, Newborn KW - Amyloid beta-Peptides -- metabolism KW - Cells, Cultured KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Signal Transduction -- drug effects KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Mutation KW - Protein Kinase C -- metabolism KW - Aspartic Acid Endopeptidases -- deficiency KW - Aspartic Acid Endopeptidases -- physiology KW - Amyloid Precursor Protein Secretases -- physiology KW - Amyloid Precursor Protein Secretases -- deficiency KW - Amyloid Precursor Protein Secretases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70292972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+aging&rft.atitle=Activation+of+protein+kinase+C+modulates+BACE1-mediated+beta-secretase+activity.&rft.au=Wang%2C+Lizhen%3BShim%2C+Hoon%3BXie%2C+Chengsong%3BCai%2C+Huaibin&rft.aulast=Wang&rft.aufirst=Lizhen&rft.date=2008-03-01&rft.volume=29&rft.issue=3&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+aging&rft.issn=1558-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2005 Dec 14;25(50):11693-709 [16354928] Nat Neurosci. 2005 Oct;8(10):1343-9 [16136043] J Biol Chem. 2000 Jul 14;275(28):21099-106 [10887202] Neurochem Res. 2000 Oct;25(9-10):1161-72 [11059790] Biochem J. 2000 Oct 1;351(Pt 1):95-105 [10998351] Nat Neurosci. 2001 Mar;4(3):233-4 [11224536] J Biol Chem. 2001 May 4;276(18):14634-41 [11278841] Med Res Rev. 2001 Jul;21(4):245-73 [11410931] J Biol Chem. 2001 Sep 28;276(39):36788-96 [11466313] J Biol Chem. 2002 Feb 15;277(7):5637-43 [11741885] Mol Cell Neurosci. 2002 Feb;19(2):175-85 [11860271] J Biol Chem. 2002 Sep 27;277(39):36415-24 [12087104] Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11735-40 [14504402] Mol Cell Neurosci. 2003 Nov;24(3):646-55 [14664815] Neuron. 2004 Jan 8;41(1):27-33 [14715132] FASEB J. 2004 Oct;18(13):1571-3 [15289451] J Neurosci. 1990 Jul;10(7):2400-11 [2115911] Science. 1992 Apr 10;256(5054):184-5 [1566067] Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10075-8 [1359534] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2628-32 [8464868] J Biol Chem. 1993 Nov 5;268(31):22959-62 [8226807] Annu Rev Cell Biol. 1994;10:373-403 [7888181] J Biol Chem. 1995 Jun 23;270(25):14843-6 [7797459] J Biol Chem. 1995 Oct 6;270(40):23243-5 [7559474] J Biol Chem. 1995 Dec 1;270(48):28495-8 [7499357] J Neurosci. 1997 Oct 1;17(19):7339-50 [9295380] J Neurosci. 1998 Mar 1;18(5):1743-52 [9464999] J Neurosci. 1998 Dec 1;18(23):9629-37 [9822724] J Neurosci. 2005 Aug 17;25(33):7567-74 [16107644] J Biol Chem. 2005 Sep 16;280(37):32499-504 [16033761] Science. 1999 Oct 22;286(5440):735-41 [10531052] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postmortem diagnosis and toxicological validation of illicit substance use. AN - 70288629; 18201295 AB - The present study examines the diagnostic challenges of identifying ante-mortem illicit substance use in human postmortem cases. Substance use, assessed by clinical case history reviews, structured next-of-kin interviews, by general toxicology of blood, urine and/or brain, and by scalp hair testing, identified 33 cocaine, 29 cannabis, 10 phencyclidine and nine opioid cases. Case history identified 42% cocaine, 76% cannabis, 10% phencyclidine and 33% opioid cases. Next-of-kin interviews identified almost twice as many cocaine and cannabis cases as Medical Examiner (ME) case histories, and were crucial in establishing a detailed lifetime substance use history. Toxicology identified 91% cocaine, 68% cannabis, 80% phencyclidine and 100% opioid cases, with hair testing increasing detection for all drug classes. A cocaine or cannabis use history was corroborated by general toxicology with 50% and 32% sensitivity, respectively, and with 82% and 64% sensitivity by hair testing. Hair testing corroborated a positive general toxicology for cocaine and cannabis with 91% and 100% sensitivity, respectively. Case history corroborated hair toxicology with 38% sensitivity for cocaine and 79% sensitivity for cannabis, suggesting that both case history and general toxicology underestimated cocaine use. Identifying ante-mortem substance use in human postmortem cases are key considerations in case diagnosis and for characterization of disorder-specific changes in neurobiology. The sensitivity and specificity of substance use assessments increased when ME case history was supplemented with structured next-of-kin interviews to establish a detailed lifetime substance use history, while comprehensive toxicology, and hair testing in particular, increased detection of recent illicit substance use. JF - Addiction biology AU - Lehrmann, Elin AU - Afanador, Zoan R AU - Deep-Soboslay, Amy AU - Gallegos, Gloria AU - Darwin, William D AU - Lowe, Ross H AU - Barnes, Allan J AU - Huestis, Marilyn A AU - Cadet, Jean L AU - Herman, Mary M AU - Hyde, Thomas M AU - Kleinman, Joel E AU - Freed, William J AD - Cellular Neurobiology Research Branch, National Institute on Drug Abuse (NIDA IRP), National Institutes of Health, Baltimore, MD 21224, USA. elehrman@intra.nida.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 105 EP - 117 VL - 13 IS - 1 KW - Street Drugs KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Cocaine-Related Disorders -- diagnosis KW - Marijuana Abuse -- pathology KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Cerebellum -- chemistry KW - Marijuana Abuse -- diagnosis KW - Cerebellum -- pathology KW - Phencyclidine Abuse -- pathology KW - Medical History Taking KW - Opioid-Related Disorders -- diagnosis KW - Cocaine-Related Disorders -- pathology KW - Hair -- chemistry KW - Opioid-Related Disorders -- pathology KW - Phencyclidine Abuse -- diagnosis KW - Body Fluids -- chemistry KW - Substance-Related Disorders -- diagnosis KW - Autopsy KW - Street Drugs -- analysis KW - Coroners and Medical Examiners KW - Substance-Related Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70288629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Postmortem+diagnosis+and+toxicological+validation+of+illicit+substance+use.&rft.au=Lehrmann%2C+Elin%3BAfanador%2C+Zoan+R%3BDeep-Soboslay%2C+Amy%3BGallegos%2C+Gloria%3BDarwin%2C+William+D%3BLowe%2C+Ross+H%3BBarnes%2C+Allan+J%3BHuestis%2C+Marilyn+A%3BCadet%2C+Jean+L%3BHerman%2C+Mary+M%3BHyde%2C+Thomas+M%3BKleinman%2C+Joel+E%3BFreed%2C+William+J&rft.aulast=Lehrmann&rft.aufirst=Elin&rft.date=2008-03-01&rft.volume=13&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=1369-1600&rft_id=info:doi/10.1111%2Fj.1369-1600.2007.00085.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-14 N1 - Date created - 2008-02-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1187-92 [15657124] Brain Res Mol Brain Res. 2005 Oct 3;139(2):317-32 [16122832] Drug Alcohol Depend. 2005 Dec 12;80(3):303-12 [15896927] J Anal Toxicol. 2005 Nov-Dec;29(8):842-3 [16356342] Addict Behav. 2006 Jan;31(1):80-9 [15908136] Forensic Sci Int. 2006 Jan 27;156(2-3):118-23 [16410161] J Mass Spectrom. 2006 Feb;41(2):175-84 [16382483] J Nerv Ment Dis. 2006 Mar;194(3):164-72 [16534433] J Clin Psychiatry. 2006 Feb;67(2):247-57 [16566620] Am J Psychiatry. 2006 Apr;163(4):689-96 [16585445] Clin Chim Acta. 2006 Aug;370(1-2):17-49 [16624267] PLoS One. 2006;1:e114 [17205118] Ther Drug Monit. 2004 Apr;26(2):200-5 [15228165] Neuropsychopharmacology. 2002 Feb;26(2):143-54 [11790510] Psychiatry Res. 2001 Dec 31;105(3):255-64 [11814544] J Anal Toxicol. 2002 Oct;26(7):393-400 [12422991] Am J Addict. 2002 Fall;11(4):255-61 [12584868] Drug Alcohol Depend. 2003 May 21;70(2):117-25 [12732403] Arch Gen Psychiatry. 2004 Jan;61(1):73-84 [14706946] Addiction. 2004 May;99(5):590-7 [15078233] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] Forensic Sci Int. 2004 Oct 29;145(2-3):143-7 [15451086] J Subst Abuse Treat. 1992;9(3):199-213 [1334156] J Anal Toxicol. 1992 Sep-Oct;16(5):276-82 [1338215] Biol Pharm Bull. 1995 Sep;18(9):1223-7 [8845810] Am J Psychiatry. 1996 Apr;153(4):533-7 [8599402] J Anal Toxicol. 1996 Jan-Feb;20(1):1-12 [8837944] J Anal Toxicol. 1996 Oct;20(6):441-52 [8889681] Acta Psychiatr Scand. 1996 Nov;94(5):337-43 [9124080] Drug Alcohol Depend. 1997 Sep 25;47(3):171-85 [9306043] Aust N Z J Psychiatry. 1998 Feb;32(1):73-6 [9565186] Subst Use Misuse. 1998 Jun;33(7):1547-67 [9657415] Biol Psychiatry. 2005 Jan 1;57(1):96-101 [15607306] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1369-1600.2007.00085.x ER - TY - JOUR T1 - Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells. AN - 70286605; 18191814 AB - The in vitro efficacy of both EGFR inhibitor gefitinib and mTor inhibitor rapamycin, either administrated alone or in different combination schedules, was analysed in four pancreas cancer cell lines. Both drugs were found to induce cell growth inhibition, apoptosis as well as a slight but stable accumulation of cells in the G0/G1 phase. In all cell lines, neither gefitinib nor rapamycin affected EGFR and the expression of its downstream effectors. By contrast, gefitinib inhibited in a fast and completely way p-EGFR and partially p-Akt while a 3 days-rapamycin exposure resulted in the inhibition of the expression of both mTor and p70S6K. Moreover, after early stimulation, the mTor inhibitor produced a progressive, and almost complete inhibition of p-Akt. The analysis of combined gefitinib and rapamycin administration showed a clear schedule-dependent activity which turned out to be synergic only when gefitinib was given before rapamycin. This synergism seemed to depend on increase of both p-Akt and p70S6K inhibition, the greater the induction of apoptosis, the higher the decrease in cell cycle rate. Moreover, the antiangiogenic activity of the two drugs given in combination was demonstrated by a strong reduction of VEGF release which turned out to be more pronounced in the synergic schedule, and HIF-1alpha inhibition-independent. Our results suggest that the schedule of gefitinib followed by rapamycin, acting at different levels of the EGFR cellular pathway, could induce antitumor and antiangiogenic effects of clinical interest in the pancreas cancer model. JF - Biochemical pharmacology AU - Azzariti, Amalia AU - Porcelli, Letizia AU - Gatti, Giuliana AU - Nicolin, Angelo AU - Paradiso, Angelo AD - Clinical Experimental Oncology Laboratory, National Cancer Institute, Via Hahnemann 10, 70126 Bari, Italy. a.azzariti@oncologico.bari.it Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 1035 EP - 1044 VL - 75 IS - 5 KW - Angiogenesis Inhibitors KW - 0 KW - Antineoplastic Agents KW - Protein Kinase Inhibitors KW - Quinazolines KW - VEGFA protein, human KW - Vascular Endothelial Growth Factor A KW - Protein Kinases KW - EC 2.7.- KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - gefitinib KW - S65743JHBS KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Protein Kinases -- metabolism KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Receptor, Epidermal Growth Factor -- metabolism KW - Humans KW - Apoptosis -- drug effects KW - Cell Line, Tumor KW - Drug Synergism KW - Cell Cycle -- drug effects KW - Vascular Endothelial Growth Factor A -- metabolism KW - Angiogenesis Inhibitors -- pharmacology KW - Pancreatic Neoplasms -- metabolism KW - Protein Kinase Inhibitors -- pharmacology KW - Sirolimus -- pharmacology KW - Pancreatic Neoplasms -- drug therapy KW - Antineoplastic Agents -- pharmacology KW - Quinazolines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70286605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Synergic+antiproliferative+and+antiangiogenic+effects+of+EGFR+and+mTor+inhibitors+on+pancreatic+cancer+cells.&rft.au=Azzariti%2C+Amalia%3BPorcelli%2C+Letizia%3BGatti%2C+Giuliana%3BNicolin%2C+Angelo%3BParadiso%2C+Angelo&rft.aulast=Azzariti&rft.aufirst=Amalia&rft.date=2008-03-01&rft.volume=75&rft.issue=5&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2007.11.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-25 N1 - Date created - 2008-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bcp.2007.11.018 ER - TY - JOUR T1 - Evidence for CALM in directing VAMP2 trafficking. AN - 70278290; 18182011 AB - Clathrin assembly lymphoid myeloid leukemia protein (CALM) is a clathrin assembly protein with a domain structure similar to the neuron-specific assembly protein AP180. We have previously found that CALM is expressed in neurons and present in synapses. We now report that CALM has a neuron-related function: it facilitates the endocytosis of the synaptic vesicle protein VAMP2 from the plasma membrane. Overexpression of CALM leads to the reduction of cell surface VAMP2, whereas knockdown of CALM by RNA interference results in the accumulation of surface VAMP2. The AP180 N-terminal homology (ANTH) domain of CALM is required for its effect on VAMP2 trafficking, and the ANTH domain itself acts as a dominant-negative mutant. Thus, our results reveal a role for CALM in directing VAMP2 trafficking during endocytosis. JF - Traffic (Copenhagen, Denmark) AU - Harel, Asaff AU - Wu, Fangbai AU - Mattson, Mark P AU - Morris, Christa M AU - Yao, Pamela J AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 417 EP - 429 VL - 9 IS - 3 SN - 1398-9219, 1398-9219 KW - Monomeric Clathrin Assembly Proteins KW - 0 KW - PICALM protein, human KW - RNA, Small Interfering KW - Recombinant Proteins KW - Transferrin KW - VAMP2 protein, human KW - Vesicle-Associated Membrane Protein 2 KW - Index Medicus KW - Animals KW - Humans KW - RNA, Small Interfering -- genetics KW - Recombinant Proteins -- genetics KW - Transferrin -- metabolism KW - Mutagenesis, Site-Directed KW - Rats KW - Endocytosis KW - Transfection KW - Recombinant Proteins -- metabolism KW - Cell Membrane -- metabolism KW - Protein Structure, Tertiary KW - RNA Interference KW - Cell Line KW - PC12 Cells KW - Protein Transport KW - Monomeric Clathrin Assembly Proteins -- metabolism KW - Monomeric Clathrin Assembly Proteins -- genetics KW - Monomeric Clathrin Assembly Proteins -- chemistry KW - Monomeric Clathrin Assembly Proteins -- antagonists & inhibitors KW - Vesicle-Associated Membrane Protein 2 -- genetics KW - Vesicle-Associated Membrane Protein 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70278290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic+%28Copenhagen%2C+Denmark%29&rft.atitle=Evidence+for+CALM+in+directing+VAMP2+trafficking.&rft.au=Harel%2C+Asaff%3BWu%2C+Fangbai%3BMattson%2C+Mark+P%3BMorris%2C+Christa+M%3BYao%2C+Pamela+J&rft.aulast=Harel&rft.aufirst=Asaff&rft.date=2008-03-01&rft.volume=9&rft.issue=3&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Traffic+%28Copenhagen%2C+Denmark%29&rft.issn=13989219&rft_id=info:doi/10.1111%2Fj.1600-0854.2007.00694.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-07 N1 - Date created - 2008-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0854.2007.00694.x ER - TY - JOUR T1 - The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats. AN - 70268716; 18155073 AB - The group III metabotropic glutamate receptor 7 (mGluR7) has been implicated in many neurological and psychiatric diseases, including drug addiction. However, it is unclear whether and how mGluR7 modulates nucleus accumbens (NAc) dopamine (DA), L-glutamate or gamma-aminobutyric acid (GABA), important neurotransmitters believed to be involved in such neuropsychiatric diseases. In the present study, we found that systemic or intra-NAc administration of the mGluR7 allosteric agonist N,N'-dibenzyhydryl-ethane-1,2-diamine dihydrochloride (AMN082) dose-dependently lowered NAc extracellular GABA and increased extracellular glutamate, but had no effect on extracellular DA levels. Such effects were blocked by (R,S)-alpha-methylserine-O-phosphate (MSOP), a group III mGluR antagonist. Intra-NAc perfusion of tetrodotoxin (TTX) blocked the AMN082-induced increases in glutamate, but failed to block the AMN082-induced reduction in GABA, suggesting vesicular glutamate and non-vesicular GABA origins for these effects. In addition, blockade of NAc GABAB receptors by 2-hydroxy-saclofen itself elevated NAc extracellular glutamate. Intra-NAc perfusion of 2-hydroxy-saclofen not only abolished the enhanced extracellular glutamate normally produced by AMN082, but also decreased extracellular glutamate in a TTX-resistant manner. We interpret these findings to suggest that the increase in glutamate is secondary to the decrease in GABA, which overcomes mGluR7 activation-induced inhibition of non-vesicular glutamate release. In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release. JF - Neuropharmacology AU - Li, Xia AU - Gardner, Eliot L AU - Xi, Zheng-Xiong AD - Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 542 EP - 551 VL - 54 IS - 3 SN - 0028-3908, 0028-3908 KW - Anesthetics, Local KW - 0 KW - Benzhydryl Compounds KW - Excitatory Amino Acid Agonists KW - Excitatory Amino Acid Antagonists KW - GABA Antagonists KW - N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride KW - methylserine phosphate KW - 2-hydroxysaclofen KW - 117354-64-0 KW - Phosphoserine KW - 17885-08-4 KW - Glutamic Acid KW - 3KX376GY7L KW - Tetrodotoxin KW - 4368-28-9 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Baclofen KW - H789N3FKE8 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Phosphoserine -- pharmacology KW - Analysis of Variance KW - Drug Interactions KW - Rats, Long-Evans KW - Anesthetics, Local -- pharmacology KW - Dose-Response Relationship, Drug KW - Baclofen -- analogs & derivatives KW - GABA Antagonists -- pharmacology KW - Microdialysis -- methods KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Rats KW - Tetrodotoxin -- pharmacology KW - Baclofen -- pharmacology KW - Male KW - Glutamic Acid -- metabolism KW - Nucleus Accumbens -- drug effects KW - Benzhydryl Compounds -- pharmacology KW - Excitatory Amino Acid Agonists -- pharmacology KW - Dopamine -- metabolism KW - gamma-Aminobutyric Acid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70268716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=The+metabotropic+glutamate+receptor+7+%28mGluR7%29+allosteric+agonist+AMN082+modulates+nucleus+accumbens+GABA+and+glutamate%2C+but+not+dopamine%2C+in+rats.&rft.au=Li%2C+Xia%3BGardner%2C+Eliot+L%3BXi%2C+Zheng-Xiong&rft.aulast=Li&rft.aufirst=Xia&rft.date=2008-03-01&rft.volume=54&rft.issue=3&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2000 Sep;75(3):889-907 [10936169] Neuropharmacology. 1996 Jun;35(6):637-42 [8887973] J Comp Neurol. 1999 Dec 13;415(2):266-84 [10545164] J Neurophysiol. 2000 May;83(5):2519-25 [10805653] J Neurophysiol. 2001 May;85(5):1960-8 [11353013] J Neurosci. 2001 Nov 15;21(22):8734-45 [11698585] Cereb Cortex. 2002 Sep;12(9):961-74 [12183395] J Physiol. 2003 Jan 15;546(Pt 2):439-53 [12527730] Eur J Neurosci. 2003 Jun;17(12):2503-20 [12823458] Behav Pharmacol. 2003 Jul;14(4):257-77 [12838033] J Neurochem. 2003 Dec;87(5):1204-12 [14622100] Curr Opin Pharmacol. 2004 Feb;4(1):18-22 [15018834] Curr Opin Pharmacol. 2004 Feb;4(1):23-9 [15018835] Eur J Neurosci. 2004 May;19(10):2727-40 [15147307] Neuropharmacology. 2004 Sep;47(3):333-41 [15275822] J Neurophysiol. 2004 Nov;92(5):2762-70 [15254073] Eur J Neurosci. 1997 Jul;9(7):1514-23 [9240409] J Neurosci. 1997 Oct 1;17(19):7503-22 [9295396] J Neurophysiol. 1997 Dec;78(6):3028-38 [9405522] Brain Res. 1998 Jan 26;782(1-2):91-104 [9519253] J Comp Neurol. 1998 Apr 13;393(3):332-52 [9548554] J Comp Neurol. 1998 Apr 20;393(4):493-504 [9550154] J Neurosci. 1998 May 1;18(9):3138-46 [9547222] J Neurochem. 1998 Aug;71(2):636-45 [9681454] J Neurophysiol. 1998 Sep;80(3):1571-6 [9744963] Eur J Neurosci. 1998 Dec;10(12):3629-41 [9875342] Brain Res Brain Res Rev. 1999 Jan;29(1):83-120 [9974152] J Pharmacol Exp Ther. 1999 Apr;289(1):412-6 [10087032] Neuropharmacology. 1999 Oct;38(10):1631-40 [10530824] Neuropharmacology. 2005;49 Suppl 1:157-66 [16084932] Nat Neurosci. 2005 Nov;8(11):1481-9 [16251991] J Comp Neurol. 2005 Dec 5;493(1):115-21 [16254990] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7 [16339898] Brain Res. 2006 Feb 16;1073-1074:297-304 [16460707] Neurosci Lett. 2006 May 15;399(1-2):151-6 [16513264] J Neurosci. 2006 Jun 14;26(24):6573-82 [16775145] Epilepsy Res. 2006 Sep;71(1):1-22 [16787741] Cell Tissue Res. 2006 Nov;326(2):483-504 [16847639] Neuropharmacology. 2007 Jan;52(1):108-17 [16914173] CNS Neurol Disord Drug Targets. 2007 Apr;6(2):87-100 [17430147] J Neurophysiol. 2007 Jul;98(1):43-53 [17507496] Psychopharmacology (Berl). 2007 Nov;194(4):555-62 [17622518] Drug Alcohol Depend. 2008 Oct 1;97(3):216-25 [18063319] Mol Psychiatry. 2008 Oct;13(10):970-9 [17712315] Neurosci Lett. 1988 Sep 23;92(1):92-6 [2847092] Neurosci Lett. 1992 Jul 6;141(1):61-4 [1508401] Neuroscience. 1993 Jun;54(4):1019-34 [8101980] Neuron. 1993 Sep;11(3):401-7 [8104430] Trends Neurosci. 1993 Oct;16(10):415-9 [7504357] Neurosci Lett. 1994 Nov 7;181(1-2):78-82 [7898776] J Neurophysiol. 1995 Jul;74(1):122-9 [7472317] J Neurosci. 1996 Mar 15;16(6):2044-56 [8604049] Nature. 1996 Jun 6;381(6582):523-5 [8632825] Eur J Pharmacol. 2000 Sep 22;404(3):289-97 [10996594] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Perspectives on genetic animal models of serotonin toxicity. AN - 70260263; 17935833 AB - Serotonin syndrome, or serotonin toxicity, is a serious disorder attributable to exaggerated serotonergic function in the brain, most commonly after antidepressant overdose or after combining several psychotropic medications. Similar condition (serotonin syndrome-like behavior) can be evoked in animals experimentally, following administration of serotonergic drugs. In addition to pharmacological stimulation, some genetic and other factors may contribute to serotonin toxicity, prompting the need for new experimental genetic models relevant to this disorder. Here we discuss current problems and perspectives regarding genetic animal models of serotonin-related syndromes, and outline the potential utility of these models in experimental neurochemistry and clinical research. JF - Neurochemistry international AU - Kalueff, Allan V AU - LaPorte, Justin L AU - Murphy, Dennis L AD - Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD 20892-1264, USA. avkalueff@inbox.ru PY - 2008 SP - 649 EP - 658 VL - 52 IS - 4-5 SN - 0197-0186, 0197-0186 KW - Serotonin KW - 333DO1RDJY KW - Index Medicus KW - Rats KW - Animals KW - Mice, Mutant Strains KW - Humans KW - Disease Models, Animal KW - Mice KW - Mice, Transgenic KW - Serotonin Syndrome -- physiopathology KW - Serotonin -- toxicity KW - Serotonin Syndrome -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70260263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Perspectives+on+genetic+animal+models+of+serotonin+toxicity.&rft.au=Kalueff%2C+Allan+V%3BLaPorte%2C+Justin+L%3BMurphy%2C+Dennis+L&rft.aulast=Kalueff&rft.aufirst=Allan&rft.date=2008-03-01&rft.volume=52&rft.issue=4-5&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-20 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tobacco use and secondhand smoke exposure of children and youth with serious chronic illness: establishing an agenda for research and action. AN - 70251001; 17329319 JF - Journal of pediatric psychology AU - Bloch, Michele AU - Haverkos, Lynne AU - Jobe, Jared B AD - Tobacco Control Research Branch, National Cancer Institute, Bethesda, MD 20892-7337, USA. blochm@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 111 EP - 112 VL - 33 IS - 2 SN - 0146-8693, 0146-8693 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Humans KW - Child KW - Adolescent KW - Male KW - Female KW - Tobacco Smoke Pollution -- prevention & control KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Smoke Pollution -- statistics & numerical data KW - Smoking Cessation -- methods KW - Tobacco Use Disorder -- prevention & control KW - Chronic Disease -- epidemiology KW - Health Promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70251001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pediatric+psychology&rft.atitle=Tobacco+use+and+secondhand+smoke+exposure+of+children+and+youth+with+serious+chronic+illness%3A+establishing+an+agenda+for+research+and+action.&rft.au=Bloch%2C+Michele%3BHaverkos%2C+Lynne%3BJobe%2C+Jared+B&rft.aulast=Bloch&rft.aufirst=Michele&rft.date=2008-03-01&rft.volume=33&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Journal+of+pediatric+psychology&rft.issn=01468693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-02 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fixed dose-rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma: a dose-finding study. AN - 70229159; 17987263 AB - In patients with newly diagnosed glioblastoma multiforme (GBM), concurrent chemo-radiotherapy with temozolomide is the new standard of care. In the present phase I study we investigated the association of gemcitabine, a cell-cycle antimetabolite with radiosensitizing properties, with radiotherapy (RT) in the first line treatment. Gemcitabine was delivered at a fixed dose-rate of 10 mg/m(2)/min weekly for 6 weeks starting 24-72 h prior to, and then concomitantly with RT (2.0 Gy per fraction, total dose 60 Gys). The primary end-point was the identification of dose-limiting toxicity (DLT), and maximum tolerated dose (MTD). Planned dose levels of gemcitabine started from 200 mg/m(2)/weekly (level 1), with sequential dose escalations of 25 mg/m(2). Ten patients were enrolled, all with evaluable disease after surgery. Six patients were male, median age was 55 years (44-75), and median baseline Karnofsky performance status was 85 (70-100). Four patients entered level 1, one patient being excluded from the study because of early disease progression. At this level, two of three patients developed progressive neurological deterioration, potentially related to the experimental treatment. On this basis gemcitabine dose was prudentially reduced to 175 mg/m(2)/weekly in the subsequent step (level -1). No DLT was encountered in the six patients enrolled at this level. Interestingly, at this dose only two grade three toxicities (one neutropenia and one raise in serum transaminases) were reported. Thus, fixed dose-rate gemcitabine at 175 mg/m(2)/weekly is the recommended regimen for further evaluation in a phase II study that is presently in progress. JF - Journal of neuro-oncology AU - Fabi, Alessandra AU - Mirri, Alessandra AU - Felici, Alessandra AU - Vidiri, Antonello AU - Pace, Andrea AU - Occhipinti, Emanuele AU - Cognetti, Francesco AU - Arcangeli, Giorgio AU - Iandolo, Bruno AU - Carosi, Maria Antonia AU - Metro, Giulio AU - Carapella, Carmine Maria AD - Division of Medical Oncology, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144, Rome, Italy. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 79 EP - 84 VL - 87 IS - 1 SN - 0167-594X, 0167-594X KW - Radiation-Sensitizing Agents KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Index Medicus KW - Kaplan-Meier Estimate KW - Survival Rate KW - Combined Modality Therapy KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Maximum Tolerated Dose KW - Male KW - Female KW - Survival Analysis KW - Brain Neoplasms -- drug therapy KW - Glioblastoma -- radiotherapy KW - Glioblastoma -- mortality KW - Deoxycytidine -- adverse effects KW - Brain Neoplasms -- mortality KW - Deoxycytidine -- analogs & derivatives KW - Brain Neoplasms -- radiotherapy KW - Deoxycytidine -- administration & dosage KW - Glioblastoma -- drug therapy KW - Radiation-Sensitizing Agents -- adverse effects KW - Radiation-Sensitizing Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70229159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=Fixed+dose-rate+gemcitabine+as+radiosensitizer+for+newly+diagnosed+glioblastoma%3A+a+dose-finding+study.&rft.au=Fabi%2C+Alessandra%3BMirri%2C+Alessandra%3BFelici%2C+Alessandra%3BVidiri%2C+Antonello%3BPace%2C+Andrea%3BOcchipinti%2C+Emanuele%3BCognetti%2C+Francesco%3BArcangeli%2C+Giorgio%3BIandolo%2C+Bruno%3BCarosi%2C+Maria+Antonia%3BMetro%2C+Giulio%3BCarapella%2C+Carmine+Maria&rft.aulast=Fabi&rft.aufirst=Alessandra&rft.date=2008-03-01&rft.volume=87&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=0167594X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-21 N1 - Date created - 2008-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of other tobacco products among U.S. adult cigarette smokers: prevalence, trends and correlates. AN - 70191085; 18053653 AB - This paper examines the trends in concurrent use of cigarettes and other tobacco and sociodemographic variables associated with concurrent use among adult cigarette smokers in the United States. Data from the 1995/96, 1998, 2000, and 2001/02 Tobacco Use Supplements to the Current Population Survey were used to estimate concurrent use of tobacco among cigarette smokers among adults ages 18 years and older (n for all 4 survey groups=552,804). Concurrent use of tobacco fluctuated over the survey periods for current smokers and ranged from 3.7% in 1995/96 to 7.9% in 1998. Results from the multivariate logistic regression indicate that male current, daily, and intermittent smokers had substantially higher odds of concurrent use (OR=12.9, 11.7, 17.2, respectively) than their female counterparts. Age, race/ethnicity, geographic region, income, and survey years were significantly associated with concurrent use among current and daily smokers; for intermittent smokers, these variables and occupation were significantly associated with concurrent use. The strongest correlates for multiple tobacco use among cigarettes smokers were being male and Non-Hispanic White. These factors should be considered when planning tobacco prevention and control efforts. In addition, surveillance efforts should continue to monitor changes in concurrent use and further investigate the increased risk of cancer among smokers who also use other forms of tobacco. JF - Addictive behaviors AU - Backinger, Cathy L AU - Fagan, Pebbles AU - O'Connell, Mary E AU - Grana, Rachel AU - Lawrence, Deirdre AU - Bishop, Jennifer Anne AU - Gibson, James Todd AD - National Cancer Institute, Rockville, MD 20852, USA. backingc@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 472 EP - 489 VL - 33 IS - 3 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Socioeconomic Factors KW - Demography KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Tobacco Industry KW - Adolescent KW - Male KW - Female KW - Age Distribution KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- ethnology KW - Tobacco, Smokeless UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70191085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Use+of+other+tobacco+products+among+U.S.+adult+cigarette+smokers%3A+prevalence%2C+trends+and+correlates.&rft.au=Backinger%2C+Cathy+L%3BFagan%2C+Pebbles%3BO%27Connell%2C+Mary+E%3BGrana%2C+Rachel%3BLawrence%2C+Deirdre%3BBishop%2C+Jennifer+Anne%3BGibson%2C+James+Todd&rft.aulast=Backinger&rft.aufirst=Cathy&rft.date=2008-03-01&rft.volume=33&rft.issue=3&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-07 N1 - Date created - 2008-01-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: MMWR Morb Mortal Wkly Rep. 2005 Nov 11;54(44):1121-4 [16280969] Tob Control. 2005 Jun;14(3):181-5 [15923468] Tob Control. 2001 Sep;10(3):279-84 [11544394] Prev Med. 2004 Mar;38(3):309-17 [14766113] JAMA. 2000 Aug 9;284(6):699-705 [10927777] Prev Med. 2003 May;36(5):575-84 [12689803] Prev Med. 2002 Jun;34(6):638-48 [12052025] Prev Med. 2004 Jul;39(1):207-11 [15208004] Prev Med. 2001 Jun;32(6):521-8 [11394956] Am J Med Sci. 2003 Oct;326(4):248-54 [14557744] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene-environment interactions in the development of complex disease phenotypes. AN - 69145908; 18441400 AB - The lack of knowledge about the earliest events in disease development is due to the multi-factorial nature of disease risk. This information gap is the consequence of the lack of appreciation for the fact that most diseases arise from the complex interactions between genes and the environment as a function of the age or stage of development of the individual. Whether an environmental exposure causes illness or not is dependent on the efficiency of the so-called "environmental response machinery" (i.e., the complex of metabolic pathways that can modulate response to environmental perturbations) that one has inherited. Thus, elucidating the causes of most chronic diseases will require an understanding of both the genetic and environmental contribution to their etiology. Unfortunately, the exploration of the relationship between genes and the environment has been hampered in the past by the limited knowledge of the human genome, and by the inclination of scientists to study disease development using experimental models that consider exposure to a single environmental agent. Rarely in the past were interactions between multiple genes or between genes and environmental agents considered in studies of human disease etiology. The most critical issue is how to relate exposure-disease association studies to pathways and mechanisms. To understand how genes and environmental factors interact to perturb biological pathways to cause injury or disease, scientists will need tools with the capacity to monitor the global expression of thousands of genes, proteins and metabolites simultaneously. The generation of such data in multiple species can be used to identify conserved and functionally significant genes and pathways involved in gene-environment interactions. Ultimately, it is this knowledge that will be used to guide agencies such as the U.S. Department of Health and Human Services in decisions regarding biomedical research funding and policy. JF - International journal of environmental research and public health AU - Ramos, Rosemarie G AU - Olden, Kenneth AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD- NH04, Box 12233, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 4 EP - 11 VL - 5 IS - 1 KW - Index Medicus KW - Phenotype KW - Occupational Diseases -- genetics KW - Environmental Health -- trends KW - Disease Susceptibility -- epidemiology KW - Humans KW - Occupational Diseases -- epidemiology KW - Chronic Disease KW - Research -- trends KW - Environmental Exposure KW - Genetic Predisposition to Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69145908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Gene-environment+interactions+in+the+development+of+complex+disease+phenotypes.&rft.au=Ramos%2C+Rosemarie+G%3BOlden%2C+Kenneth&rft.aulast=Ramos&rft.aufirst=Rosemarie&rft.date=2008-03-01&rft.volume=5&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=1660-4601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-11 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1999 Dec 10;83(6):743-9 [10597189] Science. 2001 Feb 16;291(5507):1304-51 [11181995] Am J Ind Med. 2001 Mar;39(3):286-91 [11241561] Nat Rev Genet. 2000 Nov;1(2):149-53 [11253655] Toxicol Appl Pharmacol. 2001 Apr 1;172(1):75-82 [11264025] Biochim Biophys Acta. 2001;1471(2):C1-10 [11342183] Am J Public Health. 2001 Dec;91(12):1964-7 [11726375] Eur Respir J Suppl. 2001 Sep;32:127s-133s [11816820] J Immunol. 1999 Aug 1;163(3):1647-53 [10415070] Am J Hum Genet. 1962 Dec;14:353-62 [13937884] J Occup Environ Hyg. 2004 Oct;1(10):648-59 [15631056] Transpl Immunol. 2005 Aug;14(3-4):175-82 [15982560] J Occup Environ Hyg. 2005 Jun;2(6):D48-50 [16020086] Trends Immunol. 2005 Oct;26(10):543-9 [16099719] Nature. 2005 Oct 27;437(7063):1299-320 [16255080] Diabetes. 2005 Dec;54 Suppl 2:S125-36 [16306330] Science. 2005 Nov 25;310(5752):1325-6 [16311335] J Occup Environ Med. 2006 Feb;48(2):204-11 [16474270] Am J Prev Med. 2006 Aug;31(2):109-17 [16829327] Ann N Y Acad Sci. 2006 Sep;1076:703-6 [17119247] Lancet. 2007 Mar 10;369(9564):844-9 [17350453] Eur Respir J. 2007 Apr;29(4):793-803 [17400878] Int J Cancer. 2007 Jun 15;120(12):2739-43 [17290392] Am J Health Promot. 2007 Mar-Apr;21(4 Suppl):326-34 [17465178] Ann Allergy Asthma Immunol. 2007 May;98(5):455-63 [17521030] Circulation. 2007 Jun 5;115(22):2878-901 [17515457] Diabetes Obes Metab. 2007 Jul;9(4):548-57 [17587397] Proc Am Thorac Soc. 2007 Jul;4(3):221-5 [17607003] Ind Health. 2007 Jun;45(3):379-87 [17634686] Stroke. 2007 Aug;38(8):2221-7 [17600228] J Allergy Clin Immunol. 2007 Aug;120(2):322-8 [17543375] Environ Health Perspect. 2007 Sep;115(9):1264-70 [17805414] Inhal Toxicol. 2007;19 Suppl 1:161-75 [17886064] Int J Mol Med. 2007 Nov;20(5):703-7 [17912464] Occup Environ Med. 2007 Nov;64(11):717-8 [17951339] Diabet Med. 2007 Nov;24(11):1187-91 [17894829] Am J Med Genet. 2002 May 30;115(1):8-17 [12116172] Mol Cell Biochem. 2002 May-Jun;234-235(1-2):219-24 [12162437] Am J Prev Med. 2003 Feb;24(2):136-42 [12568819] EHP Toxicogenomics. 2003 Jan;111(1T):15-28 [12735106] JAMA. 2003 Aug 20;290(7):891-7 [12928465] Scand J Work Environ Health. 2004 Feb;30(1):71-9 [15018031] Int J Occup Environ Health. 2004 Jan-Mar;10(1):22-5 [15070022] Int J Occup Med Environ Health. 2004;17(1):103-10 [15212212] Am Rev Respir Dis. 1989 Jun;139(6):1479-86 [2729754] Environ Health Perspect. 1993 Apr 22;101(1):6-7 [8513765] Science. 1993 Oct 8;262(5131):242-4 [8105536] Cancer Epidemiol Biomarkers Prev. 1994 Sep;3(6):471-7 [8000297] J Mol Med (Berl). 1995 Aug;73(8):381-93 [8528740] DNA Cell Biol. 1996 Apr;15(4):273-80 [8639263] Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1076-81 [8887610] Environ Health Perspect. 1996 Oct;104 Suppl 5:937-43 [8933038] Science. 1997 Oct 24;278(5338):569-70 [9381162] Nat Genet. 1998 Feb;18(2):91-3 [9462728] Environ Health Perspect. 1998 Jul;106(7):365-8 [9637792] Am J Ind Med. 1998 Oct;34(4):318-24 [9750937] Eur Respir J. 1998 Dec;12(6):1463-75 [9877510] JAMA. 1999 Jan 27;281(4):341-6 [9929087] Toxicol Sci. 1999 Feb;47(2):135-43 [10220849] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] Science. 2000 Jul 28;289(5479):536-7 [10939962] Environ Health Perspect. 2000 Aug;108 Suppl 4:675-84 [10931786] Mutat Res. 2001 Jan 25;473(1):3-10 [11166022] Nature. 2001 Feb 15;409(6822):860-921 [11237011] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Review: Meta-analytic examination of the strong and weak principles across 48 health behaviors AN - 57295571; 200914950 AB - Objective. The strong and weak principles of change state that progress from the precontemplation to the action stage of change is associated with a one standard deviation increase in the pros and a one-half standard deviation decrease in the cons of change. In this study these relationships, originally developed by Prochaska [Prochaska, J.O., 1994. Strong and weak principles for progressing from precontemplation to action on the basis of 12 problem behaviors. Health Psychology, 13, 47-51] based on an examination of 12 studies of 12 different behaviors, were re-examined using many more datasets and much more rigorous statistical methods. Methods. The current study analyzes 120 datasets from studies conducted between 1984 and 2003 across and within 48 health behaviors, including nearly 50,000 participants from 10 countries. The datasets were primarily analyzed utilizing meta-analytic techniques. Results. Despite the range of behaviors and populations, the results were remarkably consistent with the original results (pros = 1.00 standard deviation, cons = 0.56 standard deviation). Few potential moderators showed any impact on effect size distributions. Conclusions. This updated and enhanced examination of two important principles of behavior change is a significant contribution to the field of multiple health risk behaviors, as it clearly demonstrates the consistency of the theoretical principles across multiple behaviors, which has implications for developing multiple health risk behavior interventions. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Hall, Kara L AU - Rossi, Joseph S AD - University of Rhode Island, Kingston, RI, USA hallka@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 266 EP - 274 PB - Elsevier Ltd, The Netherlands VL - 46 IS - 3 SN - 0091-7435, 0091-7435 KW - Transtheoretical Model Stages of change Decisional balance Pros and cons Behavior change KW - Health risks KW - Health psychology KW - Deviation KW - Behavioural problems KW - Moderators KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57295571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Review%3A+Meta-analytic+examination+of+the+strong+and+weak+principles+across+48+health+behaviors&rft.au=Hall%2C+Kara+L%3BRossi%2C+Joseph+S&rft.aulast=Hall&rft.aufirst=Kara&rft.date=2008-03-01&rft.volume=46&rft.issue=3&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2007.11.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Deviation; Health risks; Health behaviour; Behavioural problems; Health psychology; Moderators DO - http://dx.doi.org/10.1016/j.ypmed.2007.11.006 ER - TY - JOUR T1 - Nurses' Perceptions of Research Utilization in a Corporate Health Care System AN - 57287809; 200915949 AB - Purpose : To explore selected characteristics of nurses based upon educational level (masters, baccalaureate, associate degree/diploma), years of experience, and hospital position (management, advanced practice, staff nurse) that might affect perceived availability of research resources, attitude towards research, support, and research use in practice. Design : A descriptive nonexperimental mailed survey design was used for this study. Methods : Nurses in five hospitals within a corporate hospital system were surveyed using the Research Utilization Questionnaire (RUQ). The RUQ was used to measure nurses' perceptions of research utilization in the four dimensions of perceived use of research, attitude toward research, availability of research resources, and perceived support for research activities. Findings : ANOVA was used to analyze the data. Statistically significant differences (p<.001) were found in the perceived use of research, attitude toward research, availability of research resources, and perceived support for research activities based on educational level and organizational position. No significant differences were found in the perception of nurses based on years of experience. Conclusions : The results of this study have implications for staff nurses, administrators, advanced practice nurses, and educators working in hospital systems. The different perceptions based upon educational level and hospital position can be integrated and used at all levels of nursing practice to promote research utilization and evidence-based practice initiatives within the organizational structure. Clinical Implications : The results of this study have nursing implications within administration and for nursing practice. The different perceptions that were found based upon educational level and hospital position can be positively integrated and used by administrators and by nurses all levels of nursing practice to promote research utilization and evidence based practice initiatives within the organizational structure. Adapted from the source document. JF - Journal of Nursing Scholarship AU - McCloskey, Donna Jo AD - Donna Jo McCloskey mccloskd@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 39 EP - 45 PB - Wiley-Blackwell, UK VL - 40 IS - 1 SN - 1527-6546, 1527-6546 KW - Attitudes KW - Perceptions KW - Academic achievement KW - Research transfer KW - Nurses KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57287809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nursing+Scholarship&rft.atitle=Nurses%27+Perceptions+of+Research+Utilization+in+a+Corporate+Health+Care+System&rft.au=McCloskey%2C+Donna+Jo&rft.aulast=McCloskey&rft.aufirst=Donna&rft.date=2008-03-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nursing+Scholarship&rft.issn=15276546&rft_id=info:doi/10.1111%2Fj.1547-5069.2007.00204.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hospitals; Nurses; Research transfer; Perceptions; Academic achievement; Attitudes DO - http://dx.doi.org/10.1111/j.1547-5069.2007.00204.x ER - TY - JOUR T1 - Sibling stem cell donor experiences at a single institution AN - 57251399; 200815621 AB - Allogeneic bone marrow (BM) and cytokine mobilized peripheral blood stem cell (PBSC) transplantation can be curative for patients with malignant and nonmalignant hematologic diseases. Siblings are most often selected as a donor match; however, research on sibling donors is limited and has focused primarily on conventional BM donors. This exploratory study describes the experiences of PBSC sibling donors at a single institution. Through retrospective interviews, 14 sibling donors shared their perceived needs and concerns before and after their stem cell collection. Donors identified fears about the donation procedure, and expressed the need for more information about transplant outcome and complications. The inclusion of the sibling donors themselves, rather than the report of their parents or health-care providers and the qualitative nature of the structured design allowed sibling donors to describe their concerns and thoughts without being restrained by the beliefs of the participant's parents, researcher or sibling's medical team. Suggestions for visual educational tools, psychosocial interventions and future research are provided. [Copyright 2007 John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Wiener, Lori S AU - Steffen-Smith, Emilie AU - Battles, Haven B AU - Wayne, Alan AU - Love, Cynthia P AU - Fry, Terry AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA wienerl@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 304 EP - 307 PB - John Wiley, Chichester UK VL - 17 IS - 3 SN - 1057-9249, 1057-9249 KW - Stem cells KW - Siblings KW - Parents KW - Adjustment KW - Cancer KW - Transplants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57251399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Sibling+stem+cell+donor+experiences+at+a+single+institution&rft.au=Wiener%2C+Lori+S%3BSteffen-Smith%2C+Emilie%3BBattles%2C+Haven+B%3BWayne%2C+Alan%3BLove%2C+Cynthia+P%3BFry%2C+Terry&rft.aulast=Wiener&rft.aufirst=Lori&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1222 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Transplants; Siblings; Stem cells; Parents; Adjustment; Cancer DO - http://dx.doi.org/10.1002/pon.1222 ER - TY - JOUR T1 - A Note on Some Measures of Profile Agreement AN - 57239291; 200814578 AB - Profile similarity or agreement is increasingly used in personality research and clinical practice and has potential applications in many other fields of psychology. I compared 4 measures of profile agreement-the Pearson r, Cattell's (1949) rp, McCrae's (1993) rpa, and an intraclass correlation coefficient (double entry), ICCDE-using both broad factor and specific facet profiles. Matched versus mismatched self-ratings/other ratings on the NEO Personality Inventory-3 (McCrae, Costa, & Martin, 2005) were used as criteria. At the factor level, rpa and ICCDE were comparable, and both were superior to rp in distinguishing matched versus mismatched profiles. At the facet level, ICCDE was superior to the other coefficients. The Pearson r performed better than expected. Adapted from the source document. JF - Journal of Personality Assessment AU - McCrae, Robert R AD - Gerontology Research Center, National Institute on Aging Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 105 EP - 109 PB - Lawrence Erlbaum Associates, Mahwah NJ VL - 90 IS - 2 SN - 0022-3891, 0022-3891 KW - Psychology KW - Clinical research KW - Personality KW - Correlation coefficients KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57239291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+Assessment&rft.atitle=A+Note+on+Some+Measures+of+Profile+Agreement&rft.au=McCrae%2C+Robert+R&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2008-03-01&rft.volume=90&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+Assessment&rft.issn=00223891&rft_id=info:doi/10.1080%2F00223890701845104 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - CODEN - JNPABU N1 - SubjectsTermNotLitGenreText - Personality; Clinical research; Psychology; Correlation coefficients DO - http://dx.doi.org/10.1080/00223890701845104 ER - TY - JOUR T1 - Negative Affect and Barriers to Exercise Among Early Stage Breast Cancer Patients AN - 57238051; 200814882 AB - Objective: To assess the relative frequency of and barriers to exercise among women with breast cancer while controlling for cancer-relevant and demographic factors. Design: The present study employed concurrent samples, correlational research design. Main Outcome Measures: Exercise frequency and its association with negative affect and barriers to exercise, independent of cancer treatment, among women (N = 176) with Stage I or II breast cancer who were 3, 6, and 12 months postsurgery. Results: After accounting for cancer-relevant and control variables, degree of negative affect and frequency of perceived barriers were significantly inversely associated with exercise. Conclusion: These findings suggest that attention to both emotional factors and psychosocial barriers to exercise may be warranted to further understand exercise among women with early stage breast cancer. [Copyright 2008 The American Psychological Association.] JF - Health Psychology AU - Perna, Frank M AU - Craft, Lynette AU - Carver, Charles S AU - Antoni, Michael H AD - Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd., EPN 4060, Bethesda, MD 20892 pernafm@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 275 EP - 279 PB - American Psychological Association, Washington DC VL - 27 IS - 2 SN - 0278-6133, 0278-6133 KW - exercise, breast cancer, physical activity, barriers KW - Barriers KW - Physical activity KW - Breast cancer KW - Psychosocial factors KW - Exercise KW - Negative affect KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57238051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Negative+Affect+and+Barriers+to+Exercise+Among+Early+Stage+Breast+Cancer+Patients&rft.au=Perna%2C+Frank+M%3BCraft%2C+Lynette%3BCarver%2C+Charles+S%3BAntoni%2C+Michael+H&rft.aulast=Perna&rft.aufirst=Frank&rft.date=2008-03-01&rft.volume=27&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2F0278-6133.27.2.275 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Exercise; Breast cancer; Negative affect; Physical activity; Barriers; Psychosocial factors DO - http://dx.doi.org/10.1037/0278-6133.27.2.275 ER - TY - JOUR T1 - Age at Drinking Onset, Alcohol Dependence, and Their Relation to Drug Use and Dependence, Driving Under the Influence of Drugs, and Motor-Vehicle Crash Involvement Because of Drugs AN - 57237422; 200811753 AB - Objective: We explored among people who ever consumed alcohol whether early age at drinking onset and alcohol dependence predicted drug use and dependence. We also examined among drinkers who have used drugs whether they also predict driving under the influence of drugs and motor-vehicle crash involvement because of drugs. Method: A U.S. national sample of 42,867 persons age 18 and older was surveyed in 1991-1992 (response rate = 90%). Logistic regression examined these potential associations among 27,616 respondents who ever drank alcohol, controlling for numerous demographic and personal characteristics. Results: Among "ever" drinkers, 22% used drugs, 10% had driven under the influence of drugs, and nearly 1% was in a motor-vehicle crash because of drug use, the equivalent of 1 million people. The younger the age of respondents when they first began drinking and whether they ever experienced alcohol dependence were independently associated with greater odds of ever using drugs and experiencing drug dependence. Among persons who consumed alcohol and drugs, having ever experienced drug dependence was the strongest predictor of driving under the influence of drugs and motor-vehicle crash involvement because of drug use. After controlling for drug dependence and age at first drag use, having experienced alcohol dependence was also independently associated with both outcomes. Conclusions: Efforts to prevent drug-related crashes should include drug use prevention and treatment, as well as prevention of early alcohol use and treatment of alcohol dependence. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Hingson, Ralph W AU - Heeren, Timothy AU - Edwards, Erika M AD - Division of Epidemiology and Prevention Research, National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Room 2077, Bethesda, Maryland 20892-9304 rhingson@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 192 EP - 201 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 69 IS - 2 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Age of onset KW - Road accidents KW - Drug abuse KW - Drunken driving KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57237422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Age+at+Drinking+Onset%2C+Alcohol+Dependence%2C+and+Their+Relation+to+Drug+Use+and+Dependence%2C+Driving+Under+the+Influence+of+Drugs%2C+and+Motor-Vehicle+Crash+Involvement+Because+of+Drugs&rft.au=Hingson%2C+Ralph+W%3BHeeren%2C+Timothy%3BEdwards%2C+Erika+M&rft.aulast=Hingson&rft.aufirst=Ralph&rft.date=2008-03-01&rft.volume=69&rft.issue=2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Age of onset; Alcohol consumption; Drug abuse; Drunken driving; Road accidents ER - TY - JOUR T1 - Advancing the Science of Implementation: A Workshop Summary AN - 57224296; 200806015 AB - While much has been written about reducing the gap between science and practice, relatively little progress has been made to develop a sound knowledge base underlying implementation of effective interventions. To respond to these challenges, the National Institute of Mental Health organized a workshop entitled, 'Advancing the Science of Implementation: Improving the Fit between Mental Health Intervention Development and Service Systems'. Over the 2-day workshop, a multi-disciplinary group of intervention and services researchers, implementers, methodologists, organizational theorists, and clinicians was brought together in an 'engaged scholarship' format composed of small and large-group settings to discuss the development of a sound knowledge base on the implementation of evidence-based practices. Using three specific intervention categories, participants identified constructs seen to be important to the implementation of the model in real-world systems. Following each breakout session, attendees reconvened for a full group discussion and brief presentations were conducted to highlight interventions in the areas of organizational measures, social network analysis and field opportunities. This summary describes some of the constructs relevant to implementation research and presents research questions that, if studied, will lay a solid foundation for implementation research. Adapted from the source document. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Chambers, David A AD - Division of Services and Intervention Research, National Institute of Mental Health, 6001 Executive Boulevard, RM 7133 MSC 9631, Bethesda, MD 20892-9631, USA dchamber@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - March 2008 SP - 3 EP - 10 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 1-2 SN - 0894-587X, 0894-587X KW - Evidence based KW - Mental health care KW - Implementation KW - Applied research KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57224296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Advancing+the+Science+of+Implementation%3A+A+Workshop+Summary&rft.au=Chambers%2C+David+A&rft.aulast=Chambers&rft.aufirst=David&rft.date=2008-03-01&rft.volume=35&rft.issue=1-2&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-007-0146-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Mental health care; Implementation; Evidence based; Applied research DO - http://dx.doi.org/10.1007/s10488-007-0146-7 ER - TY - JOUR T1 - On estimating diagnostic accuracy from studies with multiple raters and partial gold standard-evaluation AN - 36869661; 3539670 AB - We are often interested in estimating sensitivity and specificity of a group of raters or a set of new diagnostic tests in situations in which gold standard evaluation is expensive or invasive. Numerous authors have proposed latent modeling approaches for estimating diagnostic error without a gold standard. Albert and Dodd showed that, when modeling without a gold standard, estimates of diagnostic error can be biased when the dependence structure between tests is misspecified. In addition, they showed that choosing between different models for this dependence structure is difficult in most practical situations. While these results caution against using these latent class models, the difficulties of obtaining gold standard verification remain a practical reality. We extend two classes of models to provide a compromise that collects gold standard information on a subset of subjects but incorporates information from both the verified and nonverified subjects during estimation. We examine the robustness of diagnostic error estimation with this approach and show that choosing between competing models is easier in this context. In our analytic work and simulations, we consider situations in which verification is completely at random as well as settings in which the probability of verification depends on the actual test results. We apply our methodological work to a study designed to estimate the diagnostic error of digital radiography for gastric cancer. JF - Journal of the American Statistical Association AU - Albert, Paul S AU - Dodd, Lori E AD - National Cancer Institute, Bethesda Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 61 EP - 73 VL - 103 IS - 481 SN - 0162-1459, 0162-1459 KW - Economics KW - Accuracy KW - Diagnosis KW - Digital technology KW - Statistics KW - Statistical data KW - Statistical models KW - Statistical analysis KW - Diseases KW - Statistical methods KW - Illness KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36869661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=On+estimating+diagnostic+accuracy+from+studies+with+multiple+raters+and+partial+gold+standard-evaluation&rft.au=Albert%2C+Paul+S%3BDodd%2C+Lori+E&rft.aulast=Albert&rft.aufirst=Paul&rft.date=2008-03-01&rft.volume=103&rft.issue=481&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214507000000329 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10449 5772; 3617 6220; 6220; 12228 10919; 3557 12622; 12224 971; 12230 8163; 12225 12233; 12233 DO - http://dx.doi.org/10.1198/016214507000000329 ER - TY - JOUR T1 - The matrix stick-breaking process: flexible Bayes meta-analysis AN - 36868135; 3539692 AB - In analyzing data from multiple related studies, it often is of interest to borrow information across studies and to cluster similar studies. Although parametric hierarchical models are commonly used, of concern is sensitivity to the form chosen for the random-effects distribution. A Dirichlet process (DP) prior can allow the distribution to be unknown, while clustering studies; however, the DP does not allow local clustering of studies with respect to a subset of the coefficients without making independence assumptions. Motivated by this problem, we propose a matrix stick-breaking process (MSBP) as a prior for a matrix of random probability measures. Properties of the MSBP are considered, and methods are developed for posterior computation using Markov chain Monte Carlo. Using the MSBP as a prior for a matrix of study-specific regression coefficients, we demonstrate advantages over parametric modeling in simulated examples. The methods are further illustrated using a multinational uterotrophic bioassay study. JF - Journal of the American Statistical Association AU - Dunson, David B AU - Xue, Ya AU - Carin, Lawrence AD - National Institute of Environmental Health Sciences ; GE Global Research ; Duke University Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 317 EP - 327 VL - 103 IS - 481 SN - 0162-1459, 0162-1459 KW - Economics KW - Monte Carlo simulation KW - Statistics KW - Statistical data KW - Statistical models KW - Statistical analysis KW - Statistical methods KW - Markovian processes KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36868135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=The+matrix+stick-breaking+process%3A+flexible+Bayes+meta-analysis&rft.au=Dunson%2C+David+B%3BXue%2C+Ya%3BCarin%2C+Lawrence&rft.aulast=Dunson&rft.aufirst=David&rft.date=2008-03-01&rft.volume=103&rft.issue=481&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214507000001364 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1512 3865 4025; 12228 10919; 12224 971; 7747 12265 3865 4025 10214 12224 971 12228 10919; 8268 12265 3865 4025 10214 12224 971 12228 10919; 12230 8163; 12225 12233; 12233 DO - http://dx.doi.org/10.1198/016214507000001364 ER - TY - JOUR T1 - Incipient adult personality: the NEO-PI-3 in middle-school-aged children AN - 36814854; 3510804 AB - This study administered the NEO Personality Inventory-3 (NEO-PI-3), a more readable version of an adult measure of the Five-Factor Model, to 449 boys and girls aged 12 and 13, who described themselves or a peer. Analyses of readability, reliability, factor structure, and convergent and discriminant validity suggested that the NEO-PI-3 can be appropriately used in this age group. Personality traits in children of this age closely resemble in structure and functioning the traits of older adolescents and adults. Most gender differences known from studies of adults are found in this age group, and mean levels show continuity with older groups. The NEO-PI-3 appears to be a useful instrument for research, and potentially for clinical applications, in middle-school-aged children. Reprinted by permission of the British Psychological Society JF - British journal of developmental psychology AU - Costa, Jr., Paul T. AU - McCrae, Robert R AU - Martin, Thomas A AD - National Institute on Aging, Baltimore ; Susquehanna University Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 71 EP - 89 VL - 26 IS - 1 SN - 0261-510X, 0261-510X KW - Sociology KW - Infancy KW - Schools KW - Personality traits KW - Adults KW - Developmental psychology KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36814854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+developmental+psychology&rft.atitle=Incipient+adult+personality%3A+the+NEO-PI-3+in+middle-school-aged+children&rft.au=Costa%2C+Jr.%2C+Paul+T.%3BMcCrae%2C+Robert+R%3BMartin%2C+Thomas+A&rft.aulast=Costa&rft.aufirst=Jr.&rft.date=2008-03-01&rft.volume=26&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=British+journal+of+developmental+psychology&rft.issn=0261510X&rft_id=info:doi/10.1348%2F026151007X196273 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 603; 9429 9416 2153; 6490 2211 652 5676 646 6091 2212; 11324; 593 DO - http://dx.doi.org/10.1348/026151007X196273 ER - TY - JOUR T1 - Identification of Inhibitors for MDM2 Ubiquitin Ligase Activity from Natural Product Extracts by a Novel High-Throughput Electrochemiluminescent Screen AN - 21189636; 11621734 AB - High-throughput screening technologies have revolutionized the manner in which potential therapeutics are identified. Although they are the source of lead compounds for ~65% of anticancer and antimicrobial drugs approved by the Food and Drug Administration between 1981 and 2002, natural products have largely been excluded from modern screening programs. This is due, at least in part, to the inherent difficulties in testing complex extract mixtures, which often contain nuisance compounds, in modern bioassay systems. In this article, the authors present a novel electrochemiluminescent assay system for inhibition of MDM2 activity that is suitable for testing natural product extracts in high-throughput screening systems. The assay was used to screen more than 144,000 natural product extracts. The authors identified 1 natural product, sempervirine, that inhibited MDM2 auto-ubiquitination, MDM2-mediated p53 degradation, and led to accumulation of p53 in cells. Sempervirine preferentially induced apoptosis in transformed cells expressing wild-type p53, suggesting that it could be a potential lead for anticancer therapeutics. (Journal of Biomolecular Screening 2008:229-237) JF - Journal of Biomolecular Screening AU - Sasiela, Christy A AU - Stewart, David H AU - Kitagaki, Jirouta AU - Safiran, Yassamin J AU - Yang, Yili AU - Weissman, Allan M AU - Oberoi, Pankaj AU - Davydov, Ilia V AU - Goncharova, Ekaterina AU - Beutler, John A AU - Mcmahon, James B AU - O'Keefe, Barry R AD - Molecular Targets Development Program, National Cancer Institute, Frederick, Maryland Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 229 EP - 237 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 13 IS - 3 SN - 1087-0571, 1087-0571 KW - Biotechnology and Bioengineering Abstracts KW - MDM2 protein KW - Apoptosis KW - Transformed cells KW - natural products KW - high-throughput screening KW - p53 protein KW - Ubiquitin-protein ligase KW - Antimicrobial agents KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21189636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Identification+of+Inhibitors+for+MDM2+Ubiquitin+Ligase+Activity+from+Natural+Product+Extracts+by+a+Novel+High-Throughput+Electrochemiluminescent+Screen&rft.au=Sasiela%2C+Christy+A%3BStewart%2C+David+H%3BKitagaki%2C+Jirouta%3BSafiran%2C+Yassamin+J%3BYang%2C+Yili%3BWeissman%2C+Allan+M%3BOberoi%2C+Pankaj%3BDavydov%2C+Ilia+V%3BGoncharova%2C+Ekaterina%3BBeutler%2C+John+A%3BMcmahon%2C+James+B%3BO%27Keefe%2C+Barry+R&rft.aulast=Sasiela&rft.aufirst=Christy&rft.date=2008-03-01&rft.volume=13&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057108315038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - MDM2 protein; Apoptosis; Transformed cells; high-throughput screening; natural products; Antimicrobial agents; Ubiquitin-protein ligase; p53 protein DO - http://dx.doi.org/10.1177/1087057108315038 ER - TY - JOUR T1 - Associations between Anticipated Reactions to Genetic Test Results and Interest in Genetic Testing: Will Self-Selection Reduce the Potential for Harm? AN - 21101602; 11327498 AB - The proliferation of genetic susceptibility tests for complex diseases away from clinic settings increases the potential for harm. This study assessed whether people are likely to self-select themselves into or out of genetic testing depending on whether they believe they could cope with the results. Associations between anticipated reactions to adverse genetic test results and interest in taking genetic tests for cancer and heart disease were examined in a community sample of English adults (n = 1024). Interest in genetic testing overall was 78% for cancer risk and 80% for heart disease risk. As predicted, there were differences by anticipated reactions. People who anticipated regret about having taken a genetic test for cancer risk expressed lower interest than those who did not anticipate regret (46% vs. 89%), and people who anticipated being glad to know of increased risk status (i.e., reduced uncertainty) were more interested than those who did not look forward to reduced uncertainty (91% vs. 22%). Patterns were similar for heart disease ("regret" 66% vs. 87%; "reduced uncertainty" 87% vs. 38%). The potential for harm from future genetic susceptibility tests may be less than feared if people who anticipate adverse reactions self-select themselves out of testing. However, given that a significant proportion of people who anticipated adverse reactions also expressed interest in testing, there is still a concern about safety. It remains to be seen whether the same patterns emerge in studies that actually offer genetic tests for common gene variants in community settings. JF - Genetic Testing and Molecular Biomarkers AU - Sanderson, S C AU - Wardle, J AD - Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 59 EP - 66 VL - 12 IS - 1 SN - 1945-0265, 1945-0265 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Risk factors KW - Genetic screening KW - Cancer KW - Side effects KW - Heart diseases KW - W 30910:Imaging KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21101602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetic+Testing+and+Molecular+Biomarkers&rft.atitle=Associations+between+Anticipated+Reactions+to+Genetic+Test+Results+and+Interest+in+Genetic+Testing%3A+Will+Self-Selection+Reduce+the+Potential+for+Harm%3F&rft.au=Sanderson%2C+S+C%3BWardle%2C+J&rft.aulast=Sanderson&rft.aufirst=S&rft.date=2008-03-01&rft.volume=12&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Genetic+Testing+and+Molecular+Biomarkers&rft.issn=19450265&rft_id=info:doi/10.1089%2Fgte.2007.0047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk factors; Genetic screening; Side effects; Cancer; Heart diseases DO - http://dx.doi.org/10.1089/gte.2007.0047 ER - TY - JOUR T1 - Host Airway Proteins Interact with Staphylococcus aureus during Early Pneumonia AN - 21015309; 8037563 AB - Staphylococcus aureus is a major cause of hospital-acquired pneumonia and is emerging as an important etiological agent of community-acquired pneumonia. Little is known about the specific host-pathogen interactions that occur when S. aureus first enters the airway. A shotgun proteomics approach was utilized to identify the airway proteins associated with S. aureus during the first 6 h of infection. Host proteins eluted from bacteria recovered from the airways of mice 30 min or 6 h following intranasal inoculation under anesthesia were subjected to liquid chromatography and tandem mass spectrometry. A total of 513 host proteins were associated with S. aureus 30 min and/or 6 h postinoculation. A majority of the identified proteins were host cytosolic proteins, suggesting that S. aureus was rapidly internalized by phagocytes in the airway and that significant host cell lysis occurred during early infection. In addition, extracellular matrix and secreted proteins, including fibronectin, antimicrobial peptides, and complement components, were associated with S. aureus at both time points. The interaction of 12 host proteins shown to bind to S. aureus in vitro was demonstrated in vivo for the first time. The association of hemoglobin, which is thought to be the primary staphylococcal iron source during infection, with S. aureus in the airway was validated by immunoblotting. Thus, we used our recently developed S. aureus pneumonia model and shotgun proteomics to validate previous in vitro findings and to identify nearly 500 other proteins that interact with S. aureus in vivo. The data presented here provide novel insights into the host-pathogen interactions that occur when S. aureus enters the airway. JF - Infection and Immunity AU - Ventura, Christy L AU - Higdon, Roger AU - Kolker, Eugene AU - Skerrett, Shawn J AU - Rubens, Craig E AD - Division of Infectious Diseases, Center for Childhood Infections and Prematurity Research. Center for Developmental Therapeutics, Seattle Children's Hospital Research Institute, Seattle, Washington. Departments of Pediatrics. Medical Education and Biomedical Informatics. Medicine, University of Washington School of Medicine, Seattle, Washington. The BIATECH Institute, Seattle, Washington. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 888 EP - 898 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 3 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Immunoblotting KW - Data processing KW - Fibronectin KW - Animal models KW - Infection KW - Mass spectroscopy KW - Hemoglobin KW - Anesthesia KW - Phagocytes KW - Liquid chromatography KW - Host-pathogen interactions KW - Extracellular matrix KW - Inoculation KW - proteomics KW - Staphylococcus aureus KW - Iron KW - Antimicrobial peptides KW - Pneumonia KW - Respiratory tract KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21015309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Host+Airway+Proteins+Interact+with+Staphylococcus+aureus+during+Early+Pneumonia&rft.au=Ventura%2C+Christy+L%3BHigdon%2C+Roger%3BKolker%2C+Eugene%3BSkerrett%2C+Shawn+J%3BRubens%2C+Craig+E&rft.aulast=Ventura&rft.aufirst=Christy&rft.date=2008-03-01&rft.volume=76&rft.issue=3&rft.spage=888&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Immunoblotting; Data processing; Fibronectin; Animal models; Infection; Mass spectroscopy; Hemoglobin; Anesthesia; Liquid chromatography; Phagocytes; Extracellular matrix; Host-pathogen interactions; Inoculation; proteomics; Antimicrobial peptides; Iron; Pneumonia; Respiratory tract; Staphylococcus aureus ER - TY - JOUR T1 - Splice Mutation in the iron-Sulfur Cluster Scaffold Protein ISCU Causes Myopathy with Exercise Intolerance AN - 20952159; 8111786 AB - A myopathy with severe exercise intolerance and myogloblnuria has been described in patients from northern Sweden, with associated deficiencies of succinate dehydrogenass and aconitase in skeletal muscle. We identified the gene for the iron-sulfur cluster scaffold protein ISCU as a candidate within a region of shared homozygoslty among patients with this disease. We found a single mutation in ISCU that likely strengthens a weak splice acceptor site, with consequent exon retention. A marked reduction of ISCU mRNA and mitochondrial ISCU protein in patient muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron overload in skeletal muscle, consistent with a muscle-specific alteration of iron homeostasis in this disease. ISCU interacts with the Friedreich ataxia gene product frataxin in iron-sulfur cluster biosynthesis. Our results therefore extend the range of known human diseases that are caused by defects in iron-sulfur cluster biogenesis. JF - American Journal of Human Genetics AU - Mochel, F AU - Knight, MA AU - Tong, W-H AU - Hernandez, D AU - Ayyad, K AU - Taivassalo, T AU - Andersen, P M AU - Singleton, A AU - Rouault, T A AU - Fischbeck, KH AU - Haller, R G AD - Developmental and Metabolic Neurology Branch, NINDS, NIH, Bethesda, MD 20892, USA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 652 EP - 660 VL - 82 IS - 3 SN - 0002-9297, 0002-9297 KW - Physical Education Index; Genetics Abstracts KW - Mitochondria KW - Homeostasis KW - Iron regulatory protein KW - frataxin KW - Genetics KW - IscU protein KW - Skeletal muscle KW - Diseases KW - Exons KW - Muscles (exercise effects) KW - Muscles KW - Patients KW - Exercise KW - scaffolds KW - Friedreich's ataxia KW - mRNA KW - Physical training KW - Proteins KW - Mutation KW - Aconitate hydratase KW - Iron KW - Evolution KW - Intolerance KW - Myopathy KW - G 07880:Human Genetics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20952159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Genetics&rft.atitle=Splice+Mutation+in+the+iron-Sulfur+Cluster+Scaffold+Protein+ISCU+Causes+Myopathy+with+Exercise+Intolerance&rft.au=Mochel%2C+F%3BKnight%2C+MA%3BTong%2C+W-H%3BHernandez%2C+D%3BAyyad%2C+K%3BTaivassalo%2C+T%3BAndersen%2C+P+M%3BSingleton%2C+A%3BRouault%2C+T+A%3BFischbeck%2C+KH%3BHaller%2C+R+G&rft.aulast=Mochel&rft.aufirst=F&rft.date=2008-03-01&rft.volume=82&rft.issue=3&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Genetics&rft.issn=00029297&rft_id=info:doi/10.1016%2Fj.ajhg.2007.12.012 LA - English DB - Physical Education Index N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genetics; Muscles (exercise effects); Muscles; Proteins; Patients; Exercise; Diseases; Iron; Exons; Mitochondria; Homeostasis; Iron regulatory protein; Friedreich's ataxia; scaffolds; frataxin; Physical training; mRNA; IscU protein; Skeletal muscle; Aconitate hydratase; Mutation; Intolerance; Evolution; Myopathy DO - http://dx.doi.org/10.1016/j.ajhg.2007.12.012 ER - TY - JOUR T1 - Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of beta -Defensin 3 AN - 20929515; 8086647 AB - beta -Defensins are important in mammalian immunity displaying both antimicrobial and chemoattractant activities. Three canonical disulfide intramolecular bonds are believed to be dispensable for antimicrobial activity but essential for chemoattractant ability. However, here we show that HBD3 (human beta -defensin 3) alkylated with iodoactemide and devoid of any disulfide bonds is still a potent chemoattractant. Furthermore, when the canonical six cysteine residues are replaced with alanine, the peptide is no longer active as a chemoattractant. These findings are replicated by the murine ortholog Defb14. We restore the chemoattractant activity of Defb14 and HBD3 by introduction of a single cysteine in the fifth position (Cys super(V)) of the beta -defensin six cysteine motif. In contrast, a peptide with a single cysteine at the first position (Cys super(I)) is inactive. Moreover, a range of overlapping linear fragments of Defb14 do not act as chemoattractants, suggesting that the chemotactic activity of this peptide is not dependent solely on an epitope surrounding Cys super(V). Full-length peptides either with alkylated cysteine residues or with cysteine residues replaced with alanine are still strongly antimicrobial. Defb14 peptide fragments were also tested for antimicrobial activity, and peptides derived from the N-terminal region display potent antimicrobial activity. Thus, the chemoattractant and antimicrobial activities of beta -defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds. These findings are important for further understanding of the mechanism of action of defensins and for therapeutic design. JF - Journal of Biological Chemistry AU - Taylor, Karen AU - Clarke, David J AU - McCullough, Bryan AU - Chin, Wutharath AU - Seo, Emily AU - Yang, De AU - Oppenheim, Joost AU - Uhrin, Dusan AU - Govan, John RW AU - Campopiano, Dominic J AU - MacMillan, Derek AU - Barran, Perdita AU - Dorin, Julia R AD - Medical Research Council Human Genetics Unit, Edinburgh EH4 2XU, Scotland, United Kingdom, the School of Chemistry, University of Edinburgh, Edinburgh EH9 3JJ, United Kingdom, the Laboratory of Molecular Immunoregulation, Center for Cancer Research, Scientific Application and International Cooperation, Inc., NCI-Frederick, National Institute of Health, Frederick, Maryland 21702, the Cystic Fibrosis Laboratory, Medical Microbiology, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom, and the Department of Chemistry, Christopher Ingold Laboratories, University College London, London WC1H 0AJ, United Kingdom Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 6631 EP - 6639 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 11 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Defensins KW - Antimicrobial activity KW - Alanine KW - Cysteine KW - Chemotactic factors KW - Disulfide bonds KW - Immunity KW - Epitopes KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20929515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Analysis+and+Separation+of+Residues+Important+for+the+Chemoattractant+and+Antimicrobial+Activities+of+beta+-Defensin+3&rft.au=Taylor%2C+Karen%3BClarke%2C+David+J%3BMcCullough%2C+Bryan%3BChin%2C+Wutharath%3BSeo%2C+Emily%3BYang%2C+De%3BOppenheim%2C+Joost%3BUhrin%2C+Dusan%3BGovan%2C+John+RW%3BCampopiano%2C+Dominic+J%3BMacMillan%2C+Derek%3BBarran%2C+Perdita%3BDorin%2C+Julia+R&rft.aulast=Taylor&rft.aufirst=Karen&rft.date=2008-03-01&rft.volume=283&rft.issue=11&rft.spage=6631&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antimicrobial activity; Defensins; Alanine; Cysteine; Chemotactic factors; Disulfide bonds; Immunity; Epitopes ER - TY - JOUR T1 - Tropism and toxicity of adeno-associated viral vector serotypes 1, 2, 5, 6, 7, 8, and 9 in rat neurons and glia in vitro AN - 20893110; 8184437 AB - Recombinant adeno-associated viral (rAAV) vectors are frequently used for gene delivery to the central nervous system and are capable of transducing neurons and glia in vitro. In this study, seven serotypes of a rAAV vector expressing green fluorescent protein (GFP) were characterized for tropism and toxicity in primary cortical cells derived from embryonic rat brain. At 2 days after transduction, serotypes 1 and 5 through 8 expressed GFP predominately in glia, but by 6 days post-transduction expression was neuronal except for AAV5. AAV2 and 9 produced minimal GFP expression. Using cell viability assays, toxicity was observed at higher multiplicities of infection (MOI) for all serotypes except AAV2 and 9. The toxicity of AAV1 and 5-8 affected mostly glia as indicated by a loss of glial-marker immunoreactivity. A frameshift mutation in the GFP gene reduced overall toxicity for serotypes 1, 5 and 6, but not 7 and 8 suggesting that the toxicity was not solely due to the overexpression of GFP. Collectively, a differential tropism and toxicity was observed among the AAV serotypes on primary cortical cultures with an overall preferential glial transduction and toxicity. JF - Virology AU - Howard, D B AU - Powers, K AU - Wang, Y AU - Harvey, B K AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA, bharvey@intra.nida.nih.gov Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 24 EP - 34 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 372 IS - 1 SN - 0042-6822, 0042-6822 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Central nervous system KW - Serotypes KW - Tropism KW - Brain KW - Green fluorescent protein KW - Cell culture KW - Toxicity KW - Adeno-associated virus KW - Frameshift mutation KW - Gene transfer KW - Neurons KW - Immunoreactivity KW - Glia KW - Embryos KW - Multiplicity of infection KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - V 22310:Genetics, Taxonomy & Structure KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20893110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Tropism+and+toxicity+of+adeno-associated+viral+vector+serotypes+1%2C+2%2C+5%2C+6%2C+7%2C+8%2C+and+9+in+rat+neurons+and+glia+in+vitro&rft.au=Howard%2C+D+B%3BPowers%2C+K%3BWang%2C+Y%3BHarvey%2C+B+K&rft.aulast=Howard&rft.aufirst=D&rft.date=2008-03-01&rft.volume=372&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2007.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Central nervous system; Serotypes; Tropism; Green fluorescent protein; Brain; Cell culture; Toxicity; Frameshift mutation; Gene transfer; Neurons; Immunoreactivity; Glia; Embryos; Multiplicity of infection; Adeno-associated virus DO - http://dx.doi.org/10.1016/j.virol.2007.10.007 ER - TY - JOUR T1 - Intracellular Organic Osmolytes: Function and Regulation AN - 20892389; 8086720 AB - Cells of almost all organisms accumulate organic osmolytes when exposed to hyperosmolality, most often in the form of high salt or urea. In this review, we discuss 1) how the organic osmolytes protect; 2) the identity of osmolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals; 3) the mechanisms by which they are accumulated; 4) sensors of osmolality; 5) the signaling pathways involved; and 6) mutual counteraction by urea and methylamines. JF - Journal of Biological Chemistry AU - Burg, Maurice B AU - Ferraris, Joan D AD - Department of Health and Human Services, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 7309 EP - 7313 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 12 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Salts KW - Archaea KW - Plant protection KW - Reviews KW - Methylamine KW - Urea KW - Osmotic pressure KW - Signal transduction KW - J 02320:Cell Biology KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20892389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Intracellular+Organic+Osmolytes%3A+Function+and+Regulation&rft.au=Burg%2C+Maurice+B%3BFerraris%2C+Joan+D&rft.aulast=Burg&rft.aufirst=Maurice&rft.date=2008-03-01&rft.volume=283&rft.issue=12&rft.spage=7309&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Salts; Plant protection; Reviews; Methylamine; Urea; Osmotic pressure; Signal transduction; Archaea ER - TY - JOUR T1 - Selective isolation of genomic loci from complex genomes by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae AN - 20866744; 8052160 AB - Here, we describe a protocol for the selective isolation of any genomic fragment or gene of interest up to 250 kb in size from complex genomes as a circular yeast artificial chromosome (YAC). The method is based on transformation-associated recombination (TAR) in the yeast Saccharomyces cerevisiae between genomic DNA and a linearized TAR cloning vector containing targeting sequences homologous to a region of interest. Recombination between the vector and homologous sequences in the co- transformed mammalian DNA results in the establishment of a YAC that is able to propagate, segregate and be selected for in yeast. Yield of gene-positive clones varies from 1% to 5%. The entire procedure takes 2 weeks to complete once the TAR vector is constructed and genomic DNA is prepared. The TAR cloning method has a broad application in functional and comparative genomics, long-range haplotyping and characterization of chromosomal rearrangements, including copy number variations. JF - Nature Protocols AU - Kouprina, Natalay AU - Larionov, Vladimir Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 371 EP - 377 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 3 SN - 1754-2189, 1754-2189 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Isolation and purification KW - Recombination KW - Chromosome rearrangements KW - Nucleotide sequence KW - DNA KW - Cloning vectors KW - genomics KW - Yeast artificial chromosomes KW - Saccharomyces cerevisiae KW - copy number KW - W 30925:Genetic Engineering KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20866744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Selective+isolation+of+genomic+loci+from+complex+genomes+by+transformation-associated+recombination+cloning+in+the+yeast+Saccharomyces+cerevisiae&rft.au=Kouprina%2C+Natalay%3BLarionov%2C+Vladimir&rft.aulast=Kouprina&rft.aufirst=Natalay&rft.date=2008-03-01&rft.volume=3&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Recombination; Chromosome rearrangements; Nucleotide sequence; Cloning vectors; DNA; genomics; Yeast artificial chromosomes; copy number; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1038/nprot.2008.5 ER - TY - JOUR T1 - Dynamic monitoring of localized tumor oxygenation changes using RF pulsed electron paramagnetic resonance in conscious mice AN - 20858273; 8368730 AB - Oxygenation status is a key determinant in both tumor growth and responses to therapeutic interventions. The oxygen partial pressure (pO2) was assessed using a novel pulsed electron paramagnetic resonance (EPR) spectroscopy at 750 MHz. Crystals of lithium phthalocyanine (LiPc) implanted into either squamous cell carcinoma (SCC) tumor or femoral muscle on opposing legs of mice were tested by pulsed EPR. The results showed pO2 of SCC tumor was 2.7 - 0.4 mmHg, while in the femoral muscle it was 6.1 - 0.9 mmHg. A major advantage of pulsed EPR oximetry over conventional continuous-wave (CW) EPR oximetry is the lack of influence from subject motion, while avoiding artifacts associated with modulation or power saturation. Resonators in pulsed EPR are overcoupled to minimize recovery time. This makes changes in coupling associated with object motion minimal without influencing spectral quality. Consequently, pulsed EPR oximetry enables approximately a temporal resolution of one second in pO2 monitoring in conscious subjects, avoiding significant influence of anesthetics on the physiology being studied. The pO2 in SCC tumor and muscle was found to be higher without anesthesia (3.9 - 0.5 mmHg for tumor, 8.8 - 1.2 mmHg for muscle). These results support the advantage of pulsed EPR in examining pO2 in conscious animals with LiPc chronically implanted in predetermined regions. JF - Magnetic Resonance in Medicine AU - Matsumoto, Shingo AU - Espey, Michael Graham AU - Utsumi, Hideo AU - Devasahayam, Nallathamby AU - Matsumoto, Ken-Ichiro AU - Matsumoto, Atsuko AU - Hirata, Hiroshi AU - Wink, David A AU - Kuppusamy, Periannan AU - Subramanian, Sankaran AU - Mitchell, James B AU - Krishna, Murali C AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, murali@helix.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 619 EP - 625 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - E.S.R. KW - Muscles KW - Therapeutic applications KW - Anesthetics KW - squamous cell carcinoma KW - Crystals KW - Tumors KW - Spectroscopy KW - Femur KW - Leg KW - Oxygen KW - Anesthesia KW - N.M.R. KW - Pressure KW - Lithium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20858273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Dynamic+monitoring+of+localized+tumor+oxygenation+changes+using+RF+pulsed+electron+paramagnetic+resonance+in+conscious+mice&rft.au=Matsumoto%2C+Shingo%3BEspey%2C+Michael+Graham%3BUtsumi%2C+Hideo%3BDevasahayam%2C+Nallathamby%3BMatsumoto%2C+Ken-Ichiro%3BMatsumoto%2C+Atsuko%3BHirata%2C+Hiroshi%3BWink%2C+David+A%3BKuppusamy%2C+Periannan%3BSubramanian%2C+Sankaran%3BMitchell%2C+James+B%3BKrishna%2C+Murali+C&rft.aulast=Matsumoto&rft.aufirst=Shingo&rft.date=2008-03-01&rft.volume=59&rft.issue=3&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21500 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Muscles; Femur; E.S.R.; Crystals; N.M.R.; Anesthetics; Lithium; squamous cell carcinoma; Spectroscopy; Oxygen; Therapeutic applications; Pressure; Leg; Anesthesia DO - http://dx.doi.org/10.1002/mrm.21500 ER - TY - JOUR T1 - The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci AN - 20857319; 8364005 AB - The National Institute of Environmental Health Sciences is establishing a DNA repository named the Environmental Polymorphisms Registry (EPR). The goal is to recruit 20,000 subjects from the greater Research Triangle Park region of North Carolina and collect a sample of each subject's DNA for genetic study. Personal information Is obtained from each EPR subject and linked to their sample in coded form. Once individuals with the genotypes of interest are identified, their samples are decoded, and their names and contact information are given to scientists for follow-up studies in which genotype is important. "Recruit-by-genotype" resources such as the EPR require a transparent consent process and rigorous human subjects protection measures. Unlike the EPR, most US DNA resources are anonymous. Once scientists identify potentially significant genetic variants, they must screen new populations to find individuals with the variants of interest to study. The EPR eliminates this time consuming and expensive step. In designing the EPR, consideration was given to achieving high response rates, minimizing attrition and maximizing usefulness for future research studies. Subjects are recruited from outpatient clinics in area medical centers as well as from the general population to ascertain individuals in diverse states of health. Data are collected on race, ethnicity, gender and age, and are monitored for demographic diversity. As of November 2007, 7, 788 individuals have been recruited into the EPR and their DNA samples have been used in numerous genetic studies. EPR subjects have also been solicited for several follow-up studies with high response rates (>90%). The success of the EPR based on the number of subjects recruited and genetic studies underway, suggests that it will be a model for future DNA resources. JF - Human Genetics AU - Chulada, P C AU - Vahdat, H L AU - Sharp, R R AU - DeLozier, T C AU - Watkins, P B AU - Pusek, S N AU - Blackshear, P J AD - Clinical Research Program, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA, chulada@niehs.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 207 EP - 214 VL - 123 IS - 2 SN - 0340-6717, 0340-6717 KW - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - demography KW - USA, North Carolina KW - attrition KW - Age KW - Data processing KW - Gene polymorphism KW - Recruitment KW - Environmental health KW - Genotypes KW - Models KW - Demography KW - Gender KW - DNA KW - Parks KW - Ethnic groups KW - Races KW - G 07880:Human Genetics KW - H 12000:Epidemiology and Public Health KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Genetics&rft.atitle=The+Environmental+Polymorphisms+Registry%3A+a+DNA+resource+to+study+genetic+susceptibility+loci&rft.au=Chulada%2C+P+C%3BVahdat%2C+H+L%3BSharp%2C+R+R%3BDeLozier%2C+T+C%3BWatkins%2C+P+B%3BPusek%2C+S+N%3BBlackshear%2C+P+J&rft.aulast=Chulada&rft.aufirst=P&rft.date=2008-03-01&rft.volume=123&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Human+Genetics&rft.issn=03406717&rft_id=info:doi/10.1007%2FS00439-007-0457-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Demography; Age; Data processing; Gene polymorphism; Recruitment; Parks; Races; Ethnic groups; Models; demography; attrition; Gender; DNA; Environmental health; Genotypes; USA, North Carolina DO - http://dx.doi.org/10.1007/S00439-007-0457-5 ER - TY - JOUR T1 - 13C saturation transfer effect of carbon dioxide-bicarbonate exchange catalyzed by carbonic anhydrase in vivo AN - 20856703; 8368716 AB - Carbonic anhydrase catalyzes reversible hydration of carbon dioxide and dehydration of bicarbonate. In this article we report that the rapid exchange catalyzed by carbonic anhydrase causes a large magnetization (saturation) transfer effect on the 13C signal of bicarbonate at 160.7 ppm in vivo when the resonance of the undetectable carbon dioxide at 125.0 ppm is irradiated with RF pulses. In isoflurane-anesthetized adult rat brain the unidirectional, pseudo first-order rate constant of this exchange in the dehydration direction was determined to be 0.47 - 0.05 sec-1 following intravenous infusion of uniformly 13C-labeled glucose for labeling bicarbonate. Intralateral ventricular administration of the highly specific carbonic anhydrase inhibitor acetazolamide, which is a drug used for treating glaucoma and epilepsy, was also shown to significantly attenuate the observed 13C magnetization transfer effect of the carbon dioxide-bicarbonate exchange in the rat brain. JF - Magnetic Resonance in Medicine AU - Yang, Jehoon AU - Singh, Sujata AU - Shen, Jun AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, shenj@intra.nimh.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 492 EP - 498 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Hydration KW - acetazolamide KW - Glucose KW - Carbonate dehydratase KW - Carbon KW - Glaucoma KW - N.M.R. KW - Drugs KW - Intravenous administration KW - Brain KW - Bicarbonate KW - Epilepsy KW - Carbon dioxide KW - Dehydration KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=13C+saturation+transfer+effect+of+carbon+dioxide-bicarbonate+exchange+catalyzed+by+carbonic+anhydrase+in+vivo&rft.au=Yang%2C+Jehoon%3BSingh%2C+Sujata%3BShen%2C+Jun&rft.aulast=Yang&rft.aufirst=Jehoon&rft.date=2008-03-01&rft.volume=59&rft.issue=3&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21501 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Carbonate dehydratase; Bicarbonate; Carbon dioxide; Carbon; Brain; Dehydration; acetazolamide; Intravenous administration; Glucose; N.M.R.; Hydration; Glaucoma; Epilepsy; Drugs DO - http://dx.doi.org/10.1002/mrm.21501 ER - TY - JOUR T1 - Therapy of Advanced Established Murine Breast Cancer with a Recombinant Adenoviral ErbB-2/neu Vaccine AN - 20843672; 8084975 AB - ErbB-2 (HER-2/neu) is a transforming oncogene expressed by a substantial fraction of breast cancers, and monoclonal antibody therapy directed toward this antigen is an established treatment modality. However, not all tumors respond, and with a monoclonal antibody directed to a single epitope, there is always the risk of tumor escape. Furthermore, passive antibody therapy requires continual treatment. Whereas cancer vaccines have prevented the growth of tumors, it has been far more difficult to treat large established tumors. Here, we show that vaccination with a recombinant adenovirus expressing a truncated ErbB-2 antigen can cure large established subcutaneous ErbB-2-expressing breast cancers in mice, and can also cure extensive established lung metastatic disease. We also show that the mechanism of protection involves antibody-mediated blockade of ErbB-2 function, independent of Fc receptors. We conclude that a vaccine inducing antibodies to a functional oncogenic receptor could have tremendous therapeutic potential against cancers overexpressing such molecules. [Cancer Res 2008; 68(6):1979-87] JF - Cancer Research AU - Park, Jong Myun AU - Terabe, Masaki AU - Steel, Jason C AU - Forni, Guido AU - Sakai, Yoshio AU - Morris, John C AU - Berzofsky, Jay A AD - Vaccine Branch and Metabolism Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1979 EP - 1987 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 68 IS - 6 SN - 0008-5472, 0008-5472 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Cancer vaccines KW - ErbB-2 protein KW - double prime Fc receptors KW - Monoclonal antibodies KW - Immunotherapy KW - Adenovirus KW - Tumors KW - Obstructive lung disease KW - Metastases KW - Antibodies KW - Oncogenes KW - Breast cancer KW - Epitopes KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20843672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Therapy+of+Advanced+Established+Murine+Breast+Cancer+with+a+Recombinant+Adenoviral+ErbB-2%2Fneu+Vaccine&rft.au=Park%2C+Jong+Myun%3BTerabe%2C+Masaki%3BSteel%2C+Jason+C%3BForni%2C+Guido%3BSakai%2C+Yoshio%3BMorris%2C+John+C%3BBerzofsky%2C+Jay+A&rft.aulast=Park&rft.aufirst=Jong&rft.date=2008-03-01&rft.volume=68&rft.issue=6&rft.spage=1979&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Metastases; Cancer vaccines; Antibodies; Oncogenes; ErbB-2 protein; double prime Fc receptors; Monoclonal antibodies; Immunotherapy; Breast cancer; Tumors; Obstructive lung disease; Epitopes; Adenovirus ER - TY - JOUR T1 - Meeting Report: Batch-to-Batch Variability in Estrogenic Activity in Commercial Animal Diets--Importance and Approaches for Laboratory Animal Research AN - 20823224; 8321977 AB - We report information from two workshops sponsored by the National Institutes of Health that were held to a) assess whether dietary estrogens could significantly impact end points in experimental animals, and b) involve program participants and feed manufacturers to address the problems associated with measuring and eliminating batch-to-batch variability in rodent diets that may lead to conflicting findings in animal experiments within and between laboratories. Data were presented at the workshops showing that there is significant batch-to-batch variability in estrogenic content of commercial animal diets, and that this variability results in differences in experimental outcomes. A combination of methods were proposed to determine levels of total estrogenic activity and levels of specific estrogenic constituents in soy-containing, casein-containing, and other soy-free rodent diets. Workshop participants recommended that researchers pay greater attention to the type of diet being used in animal studies and choose a diet whose estrogenic activity (or lack thereof) is appropriate for the experimental model and end points of interest. Information about levels of specific phytoestrogens, as well as estrogenic activity caused by other contaminants and measured by bioassay, should be disclosed in scientific publications. This will require laboratory animal diet manufacturers to provide investigators with information regarding the phytoestrogen content and other estrogenic compounds in commercial diets used in animal research. JF - Environmental Health Perspectives AU - Heindel, J J AU - vom Saal, FS AD - Celluler, Organs, and Systems Pathobiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, MD 3-03, Research Triangle Park, NC 27709 USA, heindelj@niehs.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 389 VL - 116 IS - 3 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts KW - Diets KW - Animals KW - Estrogens KW - Data processing KW - Laboratory testing KW - Conferences KW - Laboratory animals KW - Animal models KW - estrogenic activity KW - Bioassays KW - Phytoestrogens KW - Contaminants KW - rodents KW - estrogens KW - Feeds KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Meeting+Report%3A+Batch-to-Batch+Variability+in+Estrogenic+Activity+in+Commercial+Animal+Diets--Importance+and+Approaches+for+Laboratory+Animal+Research&rft.au=Heindel%2C+J+J%3Bvom+Saal%2C+FS&rft.aulast=Heindel&rft.aufirst=J&rft.date=2008-03-01&rft.volume=116&rft.issue=3&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Estrogens; Data processing; Conferences; Animal models; Laboratory animals; Phytoestrogens; Contaminants; estrogenic activity; Animals; Bioassays; Laboratory testing; rodents; Feeds; estrogens ER - TY - JOUR T1 - Pilot Studies of Estrogen-Related Physical Findings in Infants AN - 20823200; 8321981 AB - BACKGROUND: Soy formula containing estrogenic isoflavones is widely used in the United States. Infants consuming soy formula exclusively have high isoflavone exposures. We wanted to study whether soy formula prolonged the physiologic estrogenization of newborns, but available quantitative descriptions of the natural history of breast and genital development are inadequate for study design. OBJECTIVE: We piloted techniques for assessing infants' responses to the withdrawal from maternal estrogen and gathered data on breast and genital development in infants at different ages. METHODS: We studied 37 boys and 35 girls, from term pregnancies with normal birth weights, who were < 48 hr to 6 months of age, and residents of Philadelphia, Pennsylvania, during 2004-2005. One-third of the children of each sex and age interval were exclusively fed breast milk, soy formula, or cow-milk formula. Our cross-sectional study measured breast adipose tissue, breast buds, and testicular volume; observed breast and genital development; and collected vaginal wall cells and information on vaginal discharge. We assessed reliability of the measures. RESULTS: Breast tissue was maximal at birth and disappeared in older children, consistent with waning maternal estrogen. Genital development did not change by age. Breast-milk secretion and withdrawal bleeding were unusual. Vaginal wall cells showed maximal estrogen effect at birth and then reverted; girls on soy appeared to show reestrogenization at 6 months. CONCLUSIONS: Examination of infants for plausible effects of estrogens is valid and repeatable. Measurement of breast tissue and characterization of vaginal wall cells could be used to evaluate exposures with estrogen-like effects. JF - Environmental Health Perspectives AU - Bernbaum, J C AU - Umbach, D M AU - Ragan, N B AU - Ballard, J L AU - Archer, JI AU - Schmidt-Davis, H AU - Rogan, W J AD - NIEHS, Post Office Box 12233, Mail Drop A3-05, Research Triangle Park, NC 27709 USA, rogan@niehs.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 416 VL - 116 IS - 3 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts KW - Testes KW - Historical account KW - Birth weight KW - Age KW - Secretion KW - adipose tissues KW - Breast milk KW - Development KW - buds KW - Isoflavones KW - birth weight KW - Estrogens KW - Milk KW - Data processing KW - USA, Pennsylvania, Philadelphia KW - Children KW - Pregnancy KW - Buds KW - Soybeans KW - USA, Pennsylvania KW - Vagina KW - Bleeding KW - Adipose tissue KW - Neonates KW - estrogens KW - Infants KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Pilot+Studies+of+Estrogen-Related+Physical+Findings+in+Infants&rft.au=Bernbaum%2C+J+C%3BUmbach%2C+D+M%3BRagan%2C+N+B%3BBallard%2C+J+L%3BArcher%2C+JI%3BSchmidt-Davis%2C+H%3BRogan%2C+W+J&rft.aulast=Bernbaum&rft.aufirst=J&rft.date=2008-03-01&rft.volume=116&rft.issue=3&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Birth weight; Estrogens; Age; Data processing; Secretion; Breast milk; Development; Children; Isoflavones; Soybeans; Buds; Pregnancy; Vagina; Bleeding; Adipose tissue; Neonates; Infants; Historical account; Milk; adipose tissues; birth weight; buds; estrogens; USA, Pennsylvania, Philadelphia; USA, Pennsylvania ER - TY - JOUR T1 - Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening AN - 20822922; 8321961 AB - BACKGROUND: The propensity of compounds to produce adverse health effects in humans is generally evaluated using animal-based test methods. Such methods can be relatively expensive, low-throughput, and associated with pain suffered by the treated animals. In addition, differences in species biology may confound extrapolation to human health effects. OBJECTIVE: The National Toxicology Program and the National Institutes of Health Chemical Genomics Center are collaborating to identify a battery of cell-based screens to prioritize compounds for further toxicologic evaluation. METHODS: A collection of 1,408 compounds previously tested in one or more traditional toxicologic assays were profiled for cytotoxicity using quantitative high-throughput screening (qHTS) in 13 human and rodent cell types derived from six common targets of xenobiotic toxicity (liver, blood, kidney, nerve, lung, skin). Selected cytotoxicants were further tested to define response kinetics. RESULTS: qHTS of these compounds produced robust and reproducible results, which allowed cross-compound, cross-cell type, and cross-species comparisons. Some compounds were cytotoxic to all cell types at similar concentrations, whereas others exhibited species- or cell type--specific cytotoxicity. Closely related cell types and analogous cell types in human and rodent frequently showed different patterns of cytotoxicity. Some compounds inducing similar levels of cytotoxicity showed distinct time dependence in kinetic studies, consistent with known mechanisms of toxicity. Conclusions: The generation of high-quality cytotoxicity data on this large library of known compounds using qHTS demonstrates the potential of this methodology to profile a much broader array of assays and compounds, which, in aggregate, may be valuable for prioritizing compounds for further toxicologic evaluation, identifying compounds with particular mechanisms of action, and potentially predicting in vivo biological response. JF - Environmental Health Perspectives AU - Xia, M AU - Huang, R AU - Witt, K L AU - Southall, N AU - Fostel, J AU - Choi, M-H AU - Jadhav, A AU - Smith, C S AU - Inglese, J AU - Portier, C J AU - Tice, R R AU - Austin, C P AD - Chemical Genomics Center, National Institutes of Health, 9800 Medical Center Dr., MSC 3370, Bethesda, MD 20892-3370 USA, austinc@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 284 VL - 116 IS - 3 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Data processing KW - Skin KW - pain KW - Pain KW - Xenobiotics KW - Toxicity KW - Nerves KW - Blood KW - Cytotoxicity KW - Lung KW - Kinetics KW - Liver KW - Kidney KW - high-throughput screening KW - genomics KW - rodents KW - Toxicology KW - H 14000:Toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20822922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Compound+Cytotoxicity+Profiling+Using+Quantitative+High-Throughput+Screening&rft.au=Xia%2C+M%3BHuang%2C+R%3BWitt%2C+K+L%3BSouthall%2C+N%3BFostel%2C+J%3BChoi%2C+M-H%3BJadhav%2C+A%3BSmith%2C+C+S%3BInglese%2C+J%3BPortier%2C+C+J%3BTice%2C+R+R%3BAustin%2C+C+P&rft.aulast=Xia&rft.aufirst=M&rft.date=2008-03-01&rft.volume=116&rft.issue=3&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nerves; Blood; Cytotoxicity; Skin; Data processing; Lung; Kinetics; Kidney; Pain; high-throughput screening; genomics; Toxicity; Liver; pain; Xenobiotics; Toxicology; rodents ER - TY - JOUR T1 - Effects of Liver X Receptor Agonist Treatment on Pulmonary Inflammation and Host Defense AN - 20771814; 8039745 AB - Liver X receptor (LXR) alpha and beta are members of the nuclear receptor superfamily of ligand-activated transcription factors. Best known for triggering "reverse cholesterol transport" gene programs upon their activation by endogenous oxysterols, LXRs have recently also been implicated in regulation of innate immunity. In this study, we define a role for LXRs in regulation of pulmonary inflammation and host defense and identify the lung and neutrophil as novel in vivo targets for pharmacologic LXR activation. LXR is expressed in murine alveolar macrophages, alveolar epithelial type II cells, and neutrophils. Treatment of mice with TO-901317, a synthetic LXR agonist, reduces influx of neutrophils to the lung triggered by inhaled LPS, intratracheal KC chemokine, and intratracheal Klebsiella pneumoniae and impairs pulmonary host defense against this bacterium. Pharmacologic LXR activation selectively modulates airspace cytokine expression induced by both LPS and K. pneumoniae. Moreover, we report for the first time that LXR activation impairs neutrophil motility and identify inhibition of chemokine-induced RhoA activation as a putative underlying mechanism. Taken together, these data define a novel role for LXR in lung pathophysiology and neutrophil biology and identify pharmacologic activation of LXR as a potential tool for modulation of innate immunity in the lung. JF - Journal of Immunology AU - Smoak, Kathleen AU - Madenspacher, Jennifer AU - Jeyaseelan, Samithamby AU - Williams, Belinda AU - Dixon, Darlene AU - Poch, Katie R AU - Nick, Jerry A AU - Worthen, GScott AU - Fessler, Michael B AD - Laboratory of Respiratory Biology and Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709. Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206 Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 3305 EP - 3312 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 5 SN - 0022-1767, 0022-1767 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Chemokines KW - Nuclear receptors KW - Leukocytes (neutrophilic) KW - Immunity KW - Cholesterol KW - Alveoli KW - Inflammation KW - Cell activation KW - RhoA protein KW - Motility KW - liver X receptors KW - Lung KW - Transcription factors KW - Cytokines KW - Lipopolysaccharides KW - Trachea KW - Klebsiella pneumoniae KW - N 14835:Protein-Nucleic Acids Association KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20771814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Effects+of+Liver+X+Receptor+Agonist+Treatment+on+Pulmonary+Inflammation+and+Host+Defense&rft.au=Smoak%2C+Kathleen%3BMadenspacher%2C+Jennifer%3BJeyaseelan%2C+Samithamby%3BWilliams%2C+Belinda%3BDixon%2C+Darlene%3BPoch%2C+Katie+R%3BNick%2C+Jerry+A%3BWorthen%2C+GScott%3BFessler%2C+Michael+B&rft.aulast=Smoak&rft.aufirst=Kathleen&rft.date=2008-03-01&rft.volume=180&rft.issue=5&rft.spage=3305&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Chemokines; Nuclear receptors; Leukocytes (neutrophilic); Cholesterol; Immunity; Alveoli; RhoA protein; Cell activation; Inflammation; Motility; Lung; liver X receptors; Transcription factors; Lipopolysaccharides; Cytokines; Trachea; Klebsiella pneumoniae ER - TY - JOUR T1 - What is the required energy deficit per unit weight loss? AN - 20767975; 8179648 AB - One of the most pervasive weight loss rules is that a cumulative energy deficit of 3500 kcal is required per pound of body weight loss, or equivalently 32.2 MJ kg@@u-1@. Under what conditions is it appropriate to use this rule of thumb and what are the factors that determine the cumulative energy deficit required per unit weight loss? Here, I examine this question using a modification of the classic Forbes equation that predicts the composition of weight loss as a function of the initial body fat and magnitude of weight loss. The resulting model predicts that a larger cumulative energy deficit is required per unit weight loss for people with greater initial body fat--a prediction supported by published weight loss data from obese and lean subjects. This may also explain why men can lose more weight than women for a given energy deficit since women typically have more body fat than men of similar body weight. Furthermore, additional weight loss is predicted to be associated with a lower average cumulative energy deficit since a greater proportion of the weight loss is predicted to result from loss of lean body mass, which has a relatively low energy density in comparison with body fat. The rule of thumb approximately matches the predicted energy density of lost weight in obese subjects with an initial body fat above 30 kg but overestimates the cumulative energy deficit required per unit weight loss for people with lower initial body fat. JF - International Journal of Obesity AU - Hall, K D AD - LBM, NIDDK/NIH, 12A South Drive, Room 4007, Bethesda, MD 20892-5621, USA, kevinh@niddk.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 573 EP - 576 VL - 32 IS - 3 SN - 0307-0565, 0307-0565 KW - Physical Education Index KW - Fingers KW - Obesity KW - Weight control KW - Weight KW - Men KW - Women KW - Rules KW - Body composition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20767975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=What+is+the+required+energy+deficit+per+unit+weight+loss%3F&rft.au=Hall%2C+K+D&rft.aulast=Hall&rft.aufirst=K&rft.date=2008-03-01&rft.volume=32&rft.issue=3&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fsj.ijo.0803720 LA - English DB - Physical Education Index N1 - Date revised - 2008-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Weight control; Body composition; Obesity; Rules; Fingers; Men; Weight; Women DO - http://dx.doi.org/10.1038/sj.ijo.0803720 ER - TY - JOUR T1 - Adiposity, Physical Activity, and Pancreatic Cancer in the National Institutes of Health-AARP Diet and Health Cohort AN - 20762472; 8083992 AB - Obesity and lack of physical activity have been inconsistently associated with pancreatic cancer. Using data from a self-administered baseline questionnaire (1995-1996), the authors investigated the association between adiposity and physical activity and pancreatic cancer in 495,035 participants of the National Institutes of Health-AARP Diet and Health Study who were aged 50-71 years. To avoid the influence of subclinical disease, follow-up time started 1 year after baseline, and subjects with a body mass index (BMI) of <18.5 kg/m@@u2@ were excluded. A subcohort (n = 302,060) completed a second questionnaire with information about physical activity and waist and hip circumference. During follow-up though 2000, 654 pancreatic cancer cases were identified. The authors used Cox proportional hazard models to generate adjusted hazard ratios and 95% confidence intervals. Compared with those with a BMI of 18.5-<25, those with a BMI of ^.35 had a 45% greater pancreatic cancer risk (95% confidence interval (CI): 1.04, 2.02; p@@dtrend@ = 0.02). Significant positive associations for BMI were observed among nonsmokers (for BMI ^.35: hazard ratio = 1.70, 95% CI: 1.14, 2.53; p@@dtrend@ = 0.004) but not recent smokers (p@@dinteraction@ = 0.08). Waist circumference was positively associated with pancreatic cancer (fourth vs. first quartile: hazard ratio = 2.53, 95% CI: 1.13, 5.65; p@@dtrend@ = 0.04) in women but not men. The authors observed no association with physical activity. Their results suggest a positive association between adiposity and pancreatic cancer. JF - American Journal of Epidemiology AU - Stolzenberg-Solomon, Rachael Z AU - Adams, Kenneth AU - Leitzmann, Michael AU - Schairer, Catherine AU - Michaud, Dominique S AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Silverman, Debra T AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 586 EP - 597 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 5 SN - 0002-9262, 0002-9262 KW - Physical Education Index KW - Waist KW - Body mass KW - Surveys KW - Health KW - Diet KW - Exercise KW - Hips KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20762472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Adiposity%2C+Physical+Activity%2C+and+Pancreatic+Cancer+in+the+National+Institutes+of+Health-AARP+Diet+and+Health+Cohort&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BAdams%2C+Kenneth%3BLeitzmann%2C+Michael%3BSchairer%2C+Catherine%3BMichaud%2C+Dominique+S%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BSilverman%2C+Debra+T&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2008-03-01&rft.volume=167&rft.issue=5&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Body mass; Exercise; Health; Waist; Diet; Surveys; Hips ER - TY - JOUR T1 - Intestinal Parasites in Kaposi Sarcoma Patients in Uganda: Indication of Shared Risk Factors or Etiologic Association AN - 20729961; 8678383 AB - Kaposi sarcoma (KS) is endemic in Uganda and shares several risk factors with intestinal parasite infestation, including rural residence, contact with suffice water, and walking barefoot, however, the significance of these ecologic relationships is unknown. We investigated these relationships among 1,985 Ugandan patients with cancer. Odds ratios (OR) were calculated using logistic regression. KS patients had higher carriage of Strongyloides stercoralis larvae (OR 2.1, 95% CI 1.2-3.7) and lower carriage of hookworm ova (0.6, 0.4-1.0) and Entamoeba coli cysts (0.7, 0.5-1.0), after adjusting for region of residence, age, gender, and diagnosis. While our findings may be due to confounding, bey are compatible with shared risk factors or etiological association between parasites and KS, and warrant well-designed follow up studies. JF - American Journal of Tropical Medicine and Hygiene AU - Lin, C J AU - Katongole-Mbidde, E AU - Byekwaso, T AU - Orem, J AU - Rabkin, C S AU - Mbulaiteye, S M AD - 6120 Executive Boulevard, Executive Plaza South Room 7080, Rockville. MD 20852, USA, mbulaits@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 409 EP - 412 VL - 78 IS - 3 SN - 0002-9637, 0002-9637 KW - Risk Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Age KW - Larvae KW - Walking KW - Uganda KW - Cysts KW - Cancer KW - Intestinal parasites KW - Infestation KW - Strongyloides stercoralis KW - Ova KW - Risk factors KW - Gender KW - Sarcoma KW - Entamoeba coli KW - Rural areas KW - K 03400:Human Diseases KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Intestinal+Parasites+in+Kaposi+Sarcoma+Patients+in+Uganda%3A+Indication+of+Shared+Risk+Factors+or+Etiologic+Association&rft.au=Lin%2C+C+J%3BKatongole-Mbidde%2C+E%3BByekwaso%2C+T%3BOrem%2C+J%3BRabkin%2C+C+S%3BMbulaiteye%2C+S+M&rft.aulast=Lin&rft.aufirst=C&rft.date=2008-03-01&rft.volume=78&rft.issue=3&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Parasites; Age; Infestation; Ova; Risk factors; Sarcoma; Walking; Cysts; Intestinal parasites; Gender; Larvae; Cancer; Rural areas; Strongyloides stercoralis; Entamoeba coli; Uganda ER - TY - JOUR T1 - Flavonoid Intake and Risk of Pancreatic Cancer in Male Smokers (Finland) AN - 20729280; 8085076 AB - Extending research on the protective effect of flavonoids in cell culture and animal studies, we examined the association between consumption of flavonoids and flavonoid-rich foods and development of exocrine pancreatic cancer within the alpha -Tocopherol, beta -Carotene Cancer Prevention Study cohort. Of the 27,111 healthy male smokers (50-69 years) who completed a self-administered dietary questionnaire at baseline, 306 developed exocrine pancreatic cancer during follow-up (1985-2004; median, 16.1 years). Intakes of total flavonoids, three flavonoid subgroups, seven individual flavonoids, and flavonoid-rich foods were estimated from a validated food frequency questionnaire. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. Overall, flavonoid intake was not significantly associated with pancreatic cancer. However, in stratified analysis, greater total flavonoid intake was associated with decreased pancreatic cancer risk in participants randomized during the trial to placebo (fourth versus first quartile: hazard ratio, 0.36; 95% confidence interval, 0.17-0.78; P sub(trend) = 0.009) and not to supplemental alpha -tocopherol (50 mg/d) and/or beta -carotene (20 mg/d; P sub(interaction) = 0.002). Similar patterns and significant interactions were observed for flavonols, flavan-3-ols, kaempferol, quercetin, catechin, and epicatechin. Our data suggest that a flavonoid-rich diet may decrease pancreatic cancer risk in male smokers not consuming supplemental alpha -tocopherol and/or beta -carotene. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):553-62) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Bobe, Gerd AU - Weinstein, Stephanie J AU - Albanes, Demetrius AU - Hirvonen, Tero AU - Ashby, Jason AU - Taylor, Phil R AU - Virtamo, Jarmo AU - Stolzenberg-Solomon, Rachael Z AD - Nutritional Epidemiology Branch and Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 553 EP - 562 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - Diets KW - pancreatic cancer KW - Finland KW - prevention KW - males KW - Cancer KW - flavonoids KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Flavonoid+Intake+and+Risk+of+Pancreatic+Cancer+in+Male+Smokers+%28Finland%29&rft.au=Bobe%2C+Gerd%3BWeinstein%2C+Stephanie+J%3BAlbanes%2C+Demetrius%3BHirvonen%2C+Tero%3BAshby%2C+Jason%3BTaylor%2C+Phil+R%3BVirtamo%2C+Jarmo%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Bobe&rft.aufirst=Gerd&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Bioindicators; pancreatic cancer; prevention; males; Cancer; flavonoids; Finland ER - TY - JOUR T1 - Polymorphisms of Genes in the Lipid Metabolism Pathway and Risk of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China AN - 20729161; 8085073 AB - Biliary tract cancers, encompassing the gallbladder, extrahepatic bile duct, and ampulla of Vater, are uncommon yet highly fatal malignancies. Gallstones, the primary risk factor for biliary cancers, are linked with hyperlipidemia. We examined the associations of 12 single nucleotide polymorphisms of five genes in the lipid metabolism pathway with the risks of biliary cancers and stones in a population-based case-control study in Shanghai, China. We included 235 gallbladder, 125 extrahepatic bile duct, and 46 ampulla of Vater cancer cases, 880 biliary stone cases, and 779 population controls. Subjects completed an in-person interview and gave blood. Genotyping was conducted by TaqMan assay using DNA from buffy coats. The effects of APOE IVS1+69 (rs440446) and APOB IVS6+360C>T (rs520354) markers were limited to men. Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of stones [95% confidence interval (95% CI), 1.2-2.4], a 1.8-fold risk of gallbladder cancer (95% CI, 1.0-3.3), a 3.7-fold risk of bile duct cancer (95% CI, 2.0-7.0), and a 4-fold risk of ampullary cancer (95% CI, 1.4-12.4). Male carriers of the T allele of APOB IVS6+360C>T had a 2-fold risk of bile duct cancer (95% CI, 1.2-3.4). The APOB T-T haplotype (APOB IVS6+360C>T, EX4+56C>T) was associated with a 1.6-fold risk of bile duct cancer (95% CI, 1.1-2.3). Male and female carriers of the T allele of LDLR IVS9-30C>T (rs1003723) had a 1.5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):525-34) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Andreotti, Gabriella AU - Chen, Jinbo AU - Gao, Yu-Tang AU - Rashid, Asif AU - Chen, Bingshu E AU - Rosenberg, Philip AU - Sakoda, Lori C AU - Deng, Jie AU - Shen, Ming-Chang AU - Wang, Bing-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen AU - Fraumeni, Joseph FJr AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 525 EP - 534 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts KW - Lipids KW - Lipoprotein (low density) receptors KW - Gene polymorphism KW - Hyperlipidemia KW - Apolipoprotein E KW - Buffy coat KW - Malignancy KW - Haplotypes KW - Risk factors KW - prevention KW - Ampulla of Vater KW - population control KW - Bioindicators KW - Bile duct KW - Genotyping KW - haplotypes KW - biomarkers KW - Biliary tract KW - Cancer KW - Lipid metabolism KW - Gallbladder KW - Blood KW - Single-nucleotide polymorphism KW - DNA KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Metabolism KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polymorphisms+of+Genes+in+the+Lipid+Metabolism+Pathway+and+Risk+of+Biliary+Tract+Cancers+and+Stones%3A+A+Population-Based+Case-Control+Study+in+Shanghai%2C+China&rft.au=Andreotti%2C+Gabriella%3BChen%2C+Jinbo%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip%3BSakoda%2C+Lori+C%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bing-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen%3BFraumeni%2C+Joseph+FJr%3BHsing%2C+Ann+W&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bile duct; Genotyping; Gene polymorphism; Lipoprotein (low density) receptors; Apolipoprotein E; Hyperlipidemia; Buffy coat; biomarkers; Cancer; Biliary tract; Lipid metabolism; Blood; Gallbladder; Malignancy; Haplotypes; Single-nucleotide polymorphism; Risk factors; DNA; Ampulla of Vater; Bioindicators; Lipids; prevention; haplotypes; population control; Metabolism; China, People's Rep., Shanghai; China, People's Rep. ER - TY - JOUR T1 - Association of IL-10 polymorphisms with prostate cancer risk and grade of disease AN - 20727601; 8153400 AB - Animal and in vitro models of prostate cancer demonstrate high IL-10 levels result in smaller tumors, fewer metastases, and reduced angiogenesis compared to controls. We sought to examine the hypothesis that genotypes correlated with low IL-10 production may be associated with increased prostate cancer risk among Finnish male participants from the Alpha-tocopherol Beta-carotene Cancer Prevention Study. DNA from 584 prostate cancer cases and 584 controls was genotyped for four IL-10 alleles, -1082, -819, -592, and 210. DNA from more of the controls than cases failed to amplify, resulting in 509 cases and 382 controls with genotype data for -1082; 507 and 384 for -819; 511 and 386 for -592; and 491 and 362 for 210. Odds ratios for the association between the IL-10 genotypes and risk of prostate cancer or, among cases only, high-grade disease were calculated using logistic regression. In this population, the -819 TT and -592 AA low expression genotypes were highly correlated. These two genotypes also were associated with increased prostate cancer susceptibility (OR = 1.92, 95% CI 1.07-3.43 for -819) and, among cases, with high-grade tumors (OR = 2.56, 95% CI 1.26-5.20 for -819). These data demonstrate genotypes correlated with low IL-10 production are associated with increased risk of prostate cancer and with high-grade disease in this population. JF - Cancer Causes & Control AU - Faupel-Badger, Jessica M AU - Kidd, La Creis Renee AU - Albanes, Demetrius AU - Virtamo, Jarmo AU - Woodson, Karen AU - Tangrea, Joseph A AD - National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 1106, Bethesda, MD, 20892-4254, USA, badgerje@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 119 EP - 124 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 19 IS - 2 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - DNA KW - prevention KW - tumors KW - Genotypes KW - prostate cancer KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Association+of+IL-10+polymorphisms+with+prostate+cancer+risk+and+grade+of+disease&rft.au=Faupel-Badger%2C+Jessica+M%3BKidd%2C+La+Creis+Renee%3BAlbanes%2C+Demetrius%3BVirtamo%2C+Jarmo%3BWoodson%2C+Karen%3BTangrea%2C+Joseph+A&rft.aulast=Faupel-Badger&rft.aufirst=Jessica&rft.date=2008-03-01&rft.volume=19&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-9077-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - prevention; DNA; tumors; Genotypes; prostate cancer; Cancer DO - http://dx.doi.org/10.1007/s10552-007-9077-6 ER - TY - JOUR T1 - Estimation and interpretation of models of absolute risk from epidemiologic data, including family-based studies AN - 20727587; 8156616 AB - Absolute risk is the chance that a person with given risk factors and free of the disease of interest at age a will be diagnosed with that disease in the interval (a, a + tau ]. Absolute risk is sometimes called cumulative incidence. Absolute risk is a 'crude' risk because it is reduced by the chance that the person will die of competing causes of death before developing the disease of interest. Cohort studies admit flexibility in modeling absolute risk, either by allowing covariates to affect the cause-specific relative hazards or to affect the absolute risk itself. An advantage of cause-specific relative risk models is that various data sources can be used to fit the required components. For example, case-control data can be used to estimate relative risk and attributable risk, and these can be combined with registry data on age-specific composite hazard rates for the disease of interest and with national data on competing hazards of mortality to estimate absolute risk. Family-based designs, such as the kin-cohort design and collections of pedigrees with multiple affected individuals can be used to estimate the genotype-specific hazard of disease. Such analyses must be adjusted for ascertainment, and failure to take into account residual familial risk, such as might be induced by unmeasured genetic variants or by unmeasured behavioral or environmental exposures that are correlated within families, can lead to overestimates of mutation-specific absolute risk in the general population. JF - Lifetime Data Analysis AU - Gail, Mitchell H AD - National Cancer Institute, 6120 Executive Blvd, EPS 8032, Bethesda, MD, 20892-7244, USA, gailm@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 18 EP - 36 PB - Kluwer Academic Publishers, [mailto:sales@wkap.nl], [URL:http://www.kluweronline.com/] VL - 14 IS - 1 SN - 1380-7870, 1380-7870 KW - Risk Abstracts KW - Mortality KW - Age KW - composite materials KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lifetime+Data+Analysis&rft.atitle=Estimation+and+interpretation+of+models+of+absolute+risk+from+epidemiologic+data%2C+including+family-based+studies&rft.au=Gail%2C+Mitchell+H&rft.aulast=Gail&rft.aufirst=Mitchell&rft.date=2008-03-01&rft.volume=14&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Lifetime+Data+Analysis&rft.issn=13807870&rft_id=info:doi/10.1007%2Fs10985-007-9070-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mortality; composite materials; Age DO - http://dx.doi.org/10.1007/s10985-007-9070-0 ER - TY - JOUR T1 - Dietary Fiber, Lung Function, and Chronic Obstructive Pulmonary Disease in the Atherosclerosis Risk in Communities Study AN - 20727499; 8083990 AB - Recent data suggest beneficial effects of fiber intake on chronic respiratory symptoms in adults that are independent of antioxidant vitamin intake, but little is known about fiber consumption in relation to lung function and chronic obstructive pulmonary disease (COPD). The authors investigated the association of fiber intake with lung function and COPD in 11,897 US men and women from the Atherosclerosis Risk in Communities study (1987-1989). After control for potential confounders, positive associations were found between lung function and fiber intake from all sources as well as from cereal or fruit alone. Compared with those in the lowest quintile, participants in the highest quintile of total fiber intake had a 60.2-ml higher forced expiratory volume in 1 second (FEV sub(1)) (p for trend < 0.001), 55.2-ml higher forced vital capacity (FVC) (p = 0.001), 0.4% higher FEV sub(1)/FVC ratio (p = 0.040), 1.8% higher percent predicted FEV sub(1) (p < 0.001), and 1.4% higher percent predicted FVC (p = 0.001). Adjusted odds ratios of COPD for the highest versus lowest quintiles of intake were 0.85 (p = 0.044) for total fiber, 0.83 (p = 0.021) for cereal fiber, and 0.72 (p = 0.005) for fruit fiber. This study provides the first known evidence that dietary fiber is independently associated with better lung function and reduced prevalence of COPD. JF - American Journal of Epidemiology AU - Kan, Haidong AU - Stevens, June AU - Heiss, Gerardo AU - Rose, Kathryn M AU - London, Stephanie J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 570 EP - 578 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 5 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Diets KW - Antioxidants KW - fruits KW - Fibers KW - vitamins KW - Respiratory function KW - chronic obstructive pulmonary disease KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Dietary+Fiber%2C+Lung+Function%2C+and+Chronic+Obstructive+Pulmonary+Disease+in+the+Atherosclerosis+Risk+in+Communities+Study&rft.au=Kan%2C+Haidong%3BStevens%2C+June%3BHeiss%2C+Gerardo%3BRose%2C+Kathryn+M%3BLondon%2C+Stephanie+J&rft.aulast=Kan&rft.aufirst=Haidong&rft.date=2008-03-01&rft.volume=167&rft.issue=5&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Fibers; Respiratory function; Diets; fruits; chronic obstructive pulmonary disease; vitamins; Antioxidants ER - TY - JOUR T1 - Multiple Diagnostic X-rays for Spine Deformities and Risk of Breast Cancer AN - 20727187; 8085082 AB - Background: Ionizing radiation is a well-established human mammary carcinogen. Women historically monitored by radiography at young ages for abnormal spinal curvature are an exposed population suitable for investigating radiation-related risk and its variation by modifying factors. In this historic cohort, 95% of daily dose increments (when exposure to the breast occurred) were under 2.4 cGy, with mean 1.1 cGy. Methods: A retrospective cohort of 3,010 women, diagnosed with spinal curvature between 1912 and 1965 in 14 U.S. pediatric orthopedic centers and who completed a questionnaire by telephone interview or mail survey in 1992, were studied for risk of breast cancer by radiation dose to the breast (mean, 12 cGy) after adjustment for established breast cancer risk factors. Results: A borderline-significant radiation dose response (excess relative risk/Gy = 2.86; P = 0.058; one-tailed P = 0.029) was observed during 118,905 woman-years of follow-up (median, 35.5 years) based on 78 cases of invasive breast cancer. The dose response was significantly greater (P = 0.03) for women who reported a family history of breast cancer in first- or second-degree relatives (excess relative risk/Gy = 8.37; 95% confidence interval, 1.50-28.16). Radiation-related risk did not vary significantly by stage of reproductive development at exposure. Conclusions: Assuming that repair of radiation-related DNA damage requires at most a few hours, our data argue against existence of a low-dose threshold on the order of 1 to 3 cGy for radiation exposure contributing to breast carcinogenesis. The possibility that a family history of breast cancer may have enhanced a carcinogenic radiation effect requires confirmation in other studies. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):605-13) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Ronckers, Cecile M AU - Doody, Michele M AU - Lonstein, John E AU - Stovall, Marilyn AU - Land, Charles E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 605 EP - 613 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Historical account KW - Invasiveness KW - Age KW - Carcinogens KW - Genetics KW - Carcinogenicity KW - Risk factors KW - prevention KW - Bioindicators KW - Inventories KW - spine KW - Data processing KW - Pediatrics KW - Orthopedics KW - Developmental stages KW - biomarkers KW - Cancer KW - DNA damage KW - USA KW - Spine KW - Ionizing radiation KW - Carcinogenesis KW - DNA KW - Breast cancer KW - Radiography KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Multiple+Diagnostic+X-rays+for+Spine+Deformities+and+Risk+of+Breast+Cancer&rft.au=Ronckers%2C+Cecile+M%3BDoody%2C+Michele+M%3BLonstein%2C+John+E%3BStovall%2C+Marilyn%3BLand%2C+Charles+E&rft.aulast=Ronckers&rft.aufirst=Cecile&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Age; Invasiveness; Data processing; Pediatrics; Orthopedics; Developmental stages; Carcinogens; biomarkers; DNA damage; Spine; Ionizing radiation; Risk factors; Carcinogenesis; Breast cancer; Radiography; Bioindicators; Historical account; spine; Cancer; Genetics; Carcinogenicity; prevention; DNA; USA ER - TY - JOUR T1 - Risk of Testicular Germ Cell Tumors and Polymorphisms in the Insulin-Like Growth Factor Genes AN - 20726905; 8085099 AB - Because taller men are at increased risk of developing testicular germ cell tumors (TGCT), it is conceivable that factors that influence adult height could be related to risk of TGCT. Because common genetic variation in genes of the insulin-like growth factor (IGF) pathway could influence somatic growth, 43 single nucleotide polymorphisms in four IGF genes (IGF-1, IGF-1R, IGF-2, and IGFALS) were genotyped in 577 case and 707 control participants from the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study to assess relationships with TGCT risk; additionally, associations between polymorphisms and adult height were examined. Relationships between polymorphisms and adult height were assessed using adjusted linear regression models, and associations between polymorphisms and TGCT risk were determined by adjusted logistic regression models estimating odds ratios. Although four IGF-1R polymorphisms (rs907806, rs3743258, rs229765, and rs9282714) were associated with height (P sub(trend) < 0.05), there were no relationships with any other polymorphism. Overall, there were no associations among polymorphisms or haplotypes in the IGF genes and TGCT risk, with odds ratios ranging from 0.55 to 1.50. Similarly, there was no association among the polymorphisms and risk of specific TGCT histologies (seminoma and nonseminoma). There was a suggestion, however, that adult height may modify the relationship between an IGF-1 haplotype and TGCT risk. These results suggest that, in aggregate, genetic variation in IGF loci is not associated with TGCT risk. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):721-6) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Chia, Victoria M AU - Sakoda, Lori C AU - Graubard, Barry I AU - Rubertone, Mark V AU - Chanock, Stephen J AU - Erickson, Ralph L AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 721 EP - 726 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Testes KW - Body height KW - Gene polymorphism KW - Bone growth KW - Genetic diversity KW - tumors KW - Haplotypes KW - prevention KW - Regression analysis KW - growth factors KW - Bioindicators KW - Insulin-like growth factor I KW - Germ cells KW - genetic diversity KW - haplotypes KW - Tumors KW - biomarkers KW - Cancer KW - USA KW - Histology KW - Single-nucleotide polymorphism KW - Insulin-like growth factors KW - seminoma KW - B 26600:Tyrosine Kinase Activity KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Risk+of+Testicular+Germ+Cell+Tumors+and+Polymorphisms+in+the+Insulin-Like+Growth+Factor+Genes&rft.au=Chia%2C+Victoria+M%3BSakoda%2C+Lori+C%3BGraubard%2C+Barry+I%3BRubertone%2C+Mark+V%3BChanock%2C+Stephen+J%3BErickson%2C+Ralph+L%3BMcGlynn%2C+Katherine+A&rft.aulast=Chia&rft.aufirst=Victoria&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Insulin-like growth factor I; Body height; Gene polymorphism; Bone growth; Germ cells; Genetic diversity; Tumors; biomarkers; Cancer; Haplotypes; Single-nucleotide polymorphism; Insulin-like growth factors; Regression analysis; seminoma; Bioindicators; Histology; prevention; genetic diversity; tumors; haplotypes; growth factors; USA ER - TY - JOUR T1 - A Prospective Study of Risk-Reducing Salpingo-oophorectomy and Longitudinal CA-125 Screening among Women at Increased Genetic Risk of Ovarian Cancer: Design and Baseline Characteristics: A Gynecologic Oncology Group Study AN - 20726656; 8085081 AB - Background: Women who are genetically predisposed to ovarian cancer are at very high risk of developing this disease. Although risk-reducing salpingo-oophorectomy (RRSO) and various screening regimens are currently recommended to reduce ovarian cancer risk, the optimal management strategy has not been established nor have multiple additional issues been adequately addressed. We developed a collaboration among the Clinical Genetics Branch (National Cancer Institute's Intramural Research Program), the Gynecologic Oncology Group (GOG), and the Cancer Genetics Network to address these issues. Methods: This is a prospective, international, two-cohort, nonrandomized study of women at genetic risk of ovarian cancer, who chose either to undergo RRSO or screening, at study enrollment. Primary study objectives include quantifying and comparing ovarian and breast cancer incidence in the two study groups, assessing feasibility and selected performance characteristics of a novel ovarian cancer screening strategy (the Risk of Ovarian Cancer Algorithm), evaluating various aspects of quality of life and nononcologic morbidity related to various interventions in at-risk women, and creating a biospecimen repository for subsequent translational research. Results: Study accrual is complete as of November 2006; 2,605 participants enrolled: 1,030 (40%) into the surgical cohort and 1,575 (60%) into the screening cohort. Five years of prospective follow-up ends in November 2011. Verification of BRCA mutation carrier status is under way, either through patient-provided reports from clinical genetic testing done before enrollment or through research-based genetic testing being conducted as part of the protocol. Patient eligibility is currently under evaluation and baseline, surgical, pathology, and outcome data are still being collected. The study design and selected baseline characteristics of cohort members are summarized. Conclusion: This National Cancer Institute intramural/extramural collaboration will provide invaluable prospectively collected observational data on women at high familial ovarian cancer risk, including substantial numbers of women carrying BRCA1/2 mutations. These data will aid in elucidating the effect of RRSO on breast/ovarian cancer risk and the effects of two management strategies, on quality of life and other issues that may influence patient care, as well as providing preliminary estimates of test specificity and positive predictive value of a novel ovarian cancer screening strategy. (Cancer Epidemiol Biomarkers Prev 2008; 17(3):594-604) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Greene, Mark H AU - Piedmonte, Marion AU - Alberts, Dave AU - Gail, Mitchell AU - Hensley, Martee AU - Miner, Zoe AU - Mai, Phuong L AU - Loud, Jennifer AU - Rodriguez, Gustavo AU - Basil, Jack AU - Boggess, John AU - Schwartz, Peter E AU - Kelley, Joseph L AU - Wakeley, Katie E AU - Minasian, Lori AU - Skates, Stephen AD - Clinical Genetics Branch, Biostatistics Branch, and Community Oncology and Prevention Trials Research Group, National Cancer Institute, Rockville, Maryland Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 594 EP - 604 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts; Genetics Abstracts KW - Feasibility studies KW - Translation KW - Pathology KW - Algorithms KW - Oncology KW - surgery KW - Morbidity KW - genetic screening KW - intervention KW - Risk factors KW - prevention KW - Genetic screening KW - Quality of life KW - Bioindicators KW - Ovarian cancer KW - Data processing KW - ovarian carcinoma KW - biomarkers KW - Cancer KW - Design KW - Breast cancer KW - BRCA1 protein KW - Females KW - quality of life KW - Mutation KW - Research programs KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=A+Prospective+Study+of+Risk-Reducing+Salpingo-oophorectomy+and+Longitudinal+CA-125+Screening+among+Women+at+Increased+Genetic+Risk+of+Ovarian+Cancer%3A+Design+and+Baseline+Characteristics%3A+A+Gynecologic+Oncology+Group+Study&rft.au=Greene%2C+Mark+H%3BPiedmonte%2C+Marion%3BAlberts%2C+Dave%3BGail%2C+Mitchell%3BHensley%2C+Martee%3BMiner%2C+Zoe%3BMai%2C+Phuong+L%3BLoud%2C+Jennifer%3BRodriguez%2C+Gustavo%3BBasil%2C+Jack%3BBoggess%2C+John%3BSchwartz%2C+Peter+E%3BKelley%2C+Joseph+L%3BWakeley%2C+Katie+E%3BMinasian%2C+Lori%3BSkates%2C+Stephen&rft.aulast=Greene&rft.aufirst=Mark&rft.date=2008-03-01&rft.volume=17&rft.issue=3&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Translation; Data processing; Algorithms; Oncology; biomarkers; Morbidity; Risk factors; BRCA1 protein; Genetic screening; Breast cancer; Mutation; Research programs; Quality of life; Feasibility studies; Bioindicators; Pathology; ovarian carcinoma; Cancer; surgery; Design; genetic screening; intervention; prevention; quality of life; Females ER - TY - JOUR T1 - Genotype analysis of the VNTR polymorphism in the SMYD3 histone methyltransferase gene: Lack of correlation with the level of histone H3 methylation in NSCLC tissues or with the risk of NSCLC AN - 20724871; 8080027 AB - Abstract not available. JF - International Journal of Cancer AU - Barlesi, Fabrice AU - Giaccone, Giuseppe AU - Gallegos-Ruiz, Marielle I AU - Span, Simone W AU - Lefesvre, Pierre AU - Kruyt, Frank A E AU - Rodriguez, Jose Antonio AD - Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands, giacconeg@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1441 EP - 1442 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 6 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Tissues KW - Gene polymorphism KW - histone methyltransferase KW - DNA methylation KW - Genotypes KW - Histone H3 KW - Methylation KW - Cancer KW - G 07880:Human Genetics KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Genotype+analysis+of+the+VNTR+polymorphism+in+the+SMYD3+histone+methyltransferase+gene%3A+Lack+of+correlation+with+the+level+of+histone+H3+methylation+in+NSCLC+tissues+or+with+the+risk+of+NSCLC&rft.au=Barlesi%2C+Fabrice%3BGiaccone%2C+Giuseppe%3BGallegos-Ruiz%2C+Marielle+I%3BSpan%2C+Simone+W%3BLefesvre%2C+Pierre%3BKruyt%2C+Frank+A+E%3BRodriguez%2C+Jose+Antonio&rft.aulast=Barlesi&rft.aufirst=Fabrice&rft.date=2008-03-01&rft.volume=122&rft.issue=6&rft.spage=1441&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23227 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - histone methyltransferase; Gene polymorphism; DNA methylation; Histone H3; Methylation; Tissues; Genotypes; Cancer DO - http://dx.doi.org/10.1002/ijc.23227 ER - TY - JOUR T1 - A method for purifying obligate intracellular Coxiella burnetii that employs digitonin lysis of host cells AN - 20707338; 8094357 AB - Purification of the obligate intracellular bacterium Coxiella burnetii requires physical disruption of infected cells. Here we describe a gentle and safe digitonin lysis procedure to release C. burnetii from infected cells. The purity, yield, and infectivity of digitonin-prepped organisms are comparable to that of organisms purified using cell lysis by sonication. JF - Journal of Microbiological Methods AU - Cockrell, D C AU - Beare, P A AU - Fischer, E R AU - Howe, D AU - Heinzen, RobertA AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, United States, rheinzen@niaid.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 321 EP - 325 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 72 IS - 3 SN - 0167-7012, 0167-7012 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Coxiella burnetii KW - Infectivity KW - Purification KW - Sonication KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20707338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=A+method+for+purifying+obligate+intracellular+Coxiella+burnetii+that+employs+digitonin+lysis+of+host+cells&rft.au=Cockrell%2C+D+C%3BBeare%2C+P+A%3BFischer%2C+E+R%3BHowe%2C+D%3BHeinzen%2C+RobertA&rft.aulast=Cockrell&rft.aufirst=D&rft.date=2008-03-01&rft.volume=72&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2007.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Infectivity; Purification; Sonication; Coxiella burnetii DO - http://dx.doi.org/10.1016/j.mimet.2007.12.015 ER - TY - JOUR T1 - Headspace volatile markers for sensitivity of cocoa (Theobroma cacao L.) somatic embryos to cryopreservation AN - 20660735; 8157397 AB - The mechanisms that reduce the viability of plant somatic embryos following cryopreservation are not known. The objective of the present study was to evaluate the sensitivity of cocoa (Theobroma cacao L.) somatic embryos at different stages of an encapsulation-dehydration protocol using stress-related volatile hydrocarbons as markers of injury and recovery. The plant stress hormone ethylene and volatile hydrocarbons derived from hydroxyl radicals (methane) and lipid peroxidation (ethane) were determined using gas chromatography headspace analysis. Ethylene and methane were the only volatiles detected, with both being produced after each step of the cryogenic protocol. Ethylene production was significantly reduced following exposure to liquid nitrogen, but then increased in parallel with embryo recovery. In contrast, the production of methane was cyclic during recovery, with the first cycle occurring earlier for embryos recovered from liquid nitrogen and desiccation than those recovered from earlier steps in the protocol. These results suggest that loss of somatic embryo viability during cryopreservation may be related to the oxidative status of the tissue, and its capacity to produce ethylene. This study has demonstrated that headspace volatile analysis provides a robust non-destructive analytical approach for assessing the survival and recovery of plant somatic embryos following cryopreservation. JF - Plant Cell Reports AU - Fang, Jong-Yi AU - Wetten, Andrew AU - Johnston, Jason AD - National Pingtung University of Science and Technology, No.1 Shueh Fu Road, Nei Pu, Pingtung, 91201, Taiwan, jyfang@mail.npust.edu.tw Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 453 EP - 461 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 27 IS - 3 SN - 0721-7714, 0721-7714 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Cocoa KW - Methane KW - Injuries KW - Hydrocarbons KW - Free radicals KW - Stress KW - Survival KW - Hormones KW - Cryopreservation KW - Lipid peroxidation KW - Theobroma cacao KW - Volatiles KW - Gas chromatography KW - Somatic embryos KW - Headspace KW - Desiccation KW - Ethylene KW - Cryogenics KW - Nitrogen KW - W 30925:Genetic Engineering KW - G 07800:Plants and Algae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20660735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plant+Cell+Reports&rft.atitle=Headspace+volatile+markers+for+sensitivity+of+cocoa+%28Theobroma+cacao+L.%29+somatic+embryos+to+cryopreservation&rft.au=Fang%2C+Jong-Yi%3BWetten%2C+Andrew%3BJohnston%2C+Jason&rft.aulast=Fang&rft.aufirst=Jong-Yi&rft.date=2008-03-01&rft.volume=27&rft.issue=3&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Plant+Cell+Reports&rft.issn=07217714&rft_id=info:doi/10.1007%2Fs00299-007-0487-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Methane; Cocoa; Injuries; Hydrocarbons; Free radicals; Survival; Stress; Cryopreservation; Hormones; Lipid peroxidation; Gas chromatography; Volatiles; Somatic embryos; Headspace; Ethylene; Desiccation; Cryogenics; Nitrogen; Theobroma cacao DO - http://dx.doi.org/10.1007/s00299-007-0487-4 ER - TY - JOUR T1 - Protein electrophoresis, immunoelectrophoresis and immunofixation electrophoresis as predictors for high-risk phenotype in familial Waldenstrom macroglobulinemia AN - 20649812; 8079989 AB - Protein electrophoresis is used for the detection, evaluation and follow-up of monoclonal gammopathy (MG) conditions such as Waldenstrom macroglobulinemia (WM). Immunofixation electrophoresis (IFE) is currently the most common method for isotyping of monoclonal gammopathy because of its superior sensitivity relative to immunoelectrophoresis (IEP). We designed a study to evaluate the clinicobiological relevance of small monoclonal bands detected by serum protein electrophoresis, IEP, and IFE. Serum protein electrophoresis, IEP, and IFE were used to evaluate possible monoclonal gammopathy in 46 members (29 relatives and 17 nonbloodline spouses) from 3 families with multiple cases of WM. IFE identified small monoclonal bands initially missed by IEP in 5 individuals (2 blood relatives, 3 spouses) among 46 study participants. All bands were IgM type. Twenty-three individuals, including the 2 blood relatives and 2 of 3 spouses with monoclonal gammopathy, were then followed for a median of 17 years (range, 13-25). The monoclonal gammopathy progressed in the 2 relatives but disappeared in the spouses, and new IgM MG developed in 2 additional relatives with a prior history of IgM polyclonal gammopathy. Small monoclonal bands detected by IFE in a familial context may be biologically meaningful, both as phenotypic biomarkers and possibly as predictors of high risk for WM. Polyclonal IgM may also be a marker of genetic susceptibility in WM families. Larger studies are needed to confirm these observations. JF - International Journal of Cancer AU - McMaster, Mary L AU - Csako, Gyorgy AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, mcmastem@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1183 EP - 1188 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 5 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Immunology Abstracts KW - Bioindicators KW - Historical account KW - Electrophoresis KW - Immunoelectrophoresis KW - Monoclonal gammopathy KW - biomarkers KW - Cancer KW - Serum proteins KW - Blood KW - Genetics KW - Macroglobulinemia KW - Risk factors KW - Risk groups KW - Gammopathy KW - Proteins KW - Immunoglobulin M KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20649812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Protein+electrophoresis%2C+immunoelectrophoresis+and+immunofixation+electrophoresis+as+predictors+for+high-risk+phenotype+in+familial+Waldenstrom+macroglobulinemia&rft.au=McMaster%2C+Mary+L%3BCsako%2C+Gyorgy&rft.aulast=McMaster&rft.aufirst=Mary&rft.date=2008-03-01&rft.volume=122&rft.issue=5&rft.spage=1183&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23229 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Electrophoresis; Proteins; Cancer; Bioindicators; Genetics; Historical account; Monoclonal gammopathy; Immunoglobulin M; Blood; Macroglobulinemia; Serum proteins; Immunoelectrophoresis; biomarkers; Gammopathy; Risk factors; Risk groups DO - http://dx.doi.org/10.1002/ijc.23229 ER - TY - JOUR T1 - Predictors of Sustained Smoking Cessation: A Prospective Analysis of Chronic Smokers From the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study AN - 20618264; 8033211 AB - OBJECTIVES: Because US smoking rates have not declined during the past decade, there is a renewed need to identify factors associated with smoking cessation. Using a nested case-control design, we explored the association between ability to sustain cessation over an extended period and demographic, smoking, medical, and behavioral variables. METHODS: We selected a sample of 1379 sustained quitters (abstinent from smoking for at least 40 months) and 1388 relapsers (abstinent for more than 8 months before relapse) from participants in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study, a nutritional intervention study involving Finnish men aged 50 to 69 years at baseline. Contingency table and multiple regression analyses were used to evaluate potential differences between the 2 groups on baseline variables. RESULTS: Compared with sustained quitters, relapsers were more likely to report symptoms of emotional distress and higher levels of nicotine dependence, to drink more alcohol, and to report more medical conditions. CONCLUSIONS: Factors associated with both tobacco use and comorbid conditions impact an individual's ability to maintain long-term smoking cessation. Understanding the underlying mechanisms of action and potential common pathways among these factors may help to improve smoking cessation therapies. JF - American Journal of Public Health AU - Augustson, Erik M AU - Wanke, Kay L AU - Rogers, Scott AU - Bergen, Andrew W AU - Chatterjee, Nilanjan AU - Synder, Kirk AU - Albanes, Demetrius AU - Taylor, Phil R AU - Caporaso, Neil E AD - Erik M. Augustson is with Scientific Applications International Corporation, Frederick, Md, and the National Cancer Institute, Division of Cancer Control and Populations Sciences, Tobacco Control Research Branch, Bethesda, Md. Kay L. Wanke, Andrew W. Bergen, Phil R. Taylor, and Neil E. Caporaso are with National Cancer Institute, Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, Bethesda. Scott Rogers is with National Cancer Institute, Division of Cancer Control and Populations Sciences, Epidemiology and Genetics Research Program, Bethesda, and the US Department of Treasury/FedSource, Bethesda. Nilanjan Chatterjee is with National Cancer Institute, Division of Cancer Epidemiology and Genetics, Biostatistics Branch, Bethesda. Kirk Synder is with Information Management Services, Inc, Bethesda. Demetrius Albanes is with National Cancer Institute, Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, Bethesda Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 549 EP - 555 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 98 IS - 3 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts KW - demography KW - Smoking KW - Alcohol KW - Nicotine KW - intervention KW - prevention KW - Tobacco KW - Cancer KW - Public health KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20618264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Predictors+of+Sustained+Smoking+Cessation%3A+A+Prospective+Analysis+of+Chronic+Smokers+From+the+Alpha-Tocopherol+Beta-Carotene+Cancer+Prevention+Study&rft.au=Augustson%2C+Erik+M%3BWanke%2C+Kay+L%3BRogers%2C+Scott%3BBergen%2C+Andrew+W%3BChatterjee%2C+Nilanjan%3BSynder%2C+Kirk%3BAlbanes%2C+Demetrius%3BTaylor%2C+Phil+R%3BCaporaso%2C+Neil+E&rft.aulast=Augustson&rft.aufirst=Erik&rft.date=2008-03-01&rft.volume=98&rft.issue=3&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - demography; Alcohol; Smoking; Nicotine; intervention; Tobacco; prevention; Cancer; Public health ER - TY - JOUR T1 - Self-Reported Age-Related Eye Diseases and Visual Impairment in the United States: Results of the 2002 National Health Interview Survey AN - 20618240; 8033198 AB - OBJECTIVES: We sought to establish national data on the prevalence of visual impairment, blindness, and selected eye conditions (cataract, diabetic retinopathy, glaucoma, and macular degeneration) and to characterize these conditions within sociodemographic subgroups. METHODS: Information on self-reported visual impairment and diagnosed eye diseases was collected from 31 044 adults. We calculated weighted prevalence estimates and odds ratios with logistic regression using SUDAAN. RESULTS: Among noninstitutionalized US adults 18 years and older, the estimated prevalence for visual impairment was 9.3% (19.1 million Americans), including 0.3% (0.7 million) with blindness. Lifetime prevalence of diagnosed diseases was as follows: cataract, 8.6% (17 million); glaucoma, 2.0% (4 million); macular degeneration, 1.1% (2 million); and diabetic retinopathy, 0.7% (1.3 million). The prevalence of diabetic retinopathy among persons with diagnosed diabetes was 9.9%. CONCLUSIONS: We present the most recently available national data on self-reported visual impairment and selected eye diseases in the United States. The results of this study provide a baseline for future public health initiatives relating to visual impairment. JF - American Journal of Public Health AU - Ryskulova, Asel AU - Turczyn, Kathleen AU - Makuc, Diane M AU - Cotch, Mary Frances AU - Klein, Richard J AU - Janiszewski, Rosemary AD - Asel Ryskulova, Kathleen Turczyn, Diane M. Makuc, and Richard J. Klein are with the Office of Analysis and Epidemiology, National Center for Health Statistics, Hyattsville, Md. Mary Frances Cotch and Rosemary Janiszewski are with the National Eye Institute, National Institutes of Health, Bethesda, Md Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 454 EP - 461 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 98 IS - 3 SN - 0090-0036, 0090-0036 KW - Sustainability Science Abstracts KW - USA KW - diabetes mellitus KW - Eye KW - macular degeneration KW - Public health KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20618240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Self-Reported+Age-Related+Eye+Diseases+and+Visual+Impairment+in+the+United+States%3A+Results+of+the+2002+National+Health+Interview+Survey&rft.au=Ryskulova%2C+Asel%3BTurczyn%2C+Kathleen%3BMakuc%2C+Diane+M%3BCotch%2C+Mary+Frances%3BKlein%2C+Richard+J%3BJaniszewski%2C+Rosemary&rft.aulast=Ryskulova&rft.aufirst=Asel&rft.date=2008-03-01&rft.volume=98&rft.issue=3&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - diabetes mellitus; Eye; macular degeneration; Public health; USA ER - TY - JOUR T1 - Occupational radiation doses to operators performing cardiac catheterization procedures AN - 20575155; 8124562 AB - Cardiac catheterization procedures using fluoroscopy reduce patient morbidity and mortality compared to oerative procedures. These diagnostic and therapeutic procedures require radiation exposure to patients and physicians. The objectives of the present investigation were to provide a systematic comprehensive summary of the reported radiation doses received by operators due to diagnostic or interventional fluoroscopically-guided procedures, to identify the primary factors influencing operator radiation dose, and to evaluate whether there have been temporal changes in the radiation doses received by operators performing these procedures. Using PubMed, we identified all English-language journal articles and other published data reporting radiation exposures to operators from diagnostic or interventional fluoroscopically-guided cardiovascular procedures from the early 1970's through the present. We abstracted the reported radiation doses, dose measurement methods, fluoroscopy system used, operational features, radiation protection features, and other relevant data. We calculated effective doses to operators in each study to facilitate comparisons. The effective doses ranged from 0.02-38.0 mu Sv for DC (diagnostic catheterizations), 0.17-31.2 mu Sv for PCI (percutaneous coronary interventions), 0.24-9.6 mu Sv for ablations, and 0.29-17.4 mu Sv for pacemaker or intracardiac deflbrillator implantations. The ratios of doses between various anatomic sites and the thyroid, measured over protective shields, were 0.9 plus or minus 1.0 for the eye, 1.0 plus or minus 1.5 for the trunk, and 13 plus or minus 2.0 for the hand. Generally, radiation dose is higher on the left side of an operator's body, because the operator's left side is closer to the primary beam when standing at the patient's right side. Modest operator dose reductions over time were observed for DC and ablation, primarily due to reduction in patient doses due to decreased fluoroscopy/cineradiography time and dose rate by technology improvement Doses were not reduced over time for PCI. The increased complexity of medical procedures appears to have offset dose reductions due to improvements in technology. The large variation in operator doses observed for the same type of procedure suggests that optimizing procedure protocols and implementing general use of the most effective types of protective devices and shields may reduce occupational radiation doses to operators. We had considerable difficulty in comparing reported dosimetry results because of significant differences in dosimetric methods used in each study and multiple factors influencing the actual doses received. Better standardization of dosimetric methods will facilitate future analyses aimed at determining how well medical radiation workers are being protected. JF - Health Physics AU - Kim, K P AU - Miller, D L AU - Baiter, S AU - Kleinerman, R A AU - Linet AU - Kwon, D AU - Simon, S L AD - DCEG/NCI/NIH, 6120 Executive Blvd., Room 7056, Bethesda, MD 20892-7238, USA, kimkwang@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 211 EP - 227 VL - 94 IS - 3 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts KW - Mortality KW - Thyroid KW - Radiation dosimetry KW - Morbidity KW - Medical personnel KW - Radiation KW - intervention KW - Standards KW - Occupational exposure KW - Technology KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20575155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Occupational+radiation+doses+to+operators+performing+cardiac+catheterization+procedures&rft.au=Kim%2C+K+P%3BMiller%2C+D+L%3BBaiter%2C+S%3BKleinerman%2C+R+A%3BLinet%3BKwon%2C+D%3BSimon%2C+S+L&rft.aulast=Kim&rft.aufirst=K&rft.date=2008-03-01&rft.volume=94&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Radiation dosimetry; Technology; Occupational exposure; Radiation; Medical personnel; Standards; Mortality; intervention; Morbidity; Thyroid ER - TY - JOUR T1 - KUTE-BASE: storing, downloading and exporting MIAME-compliant microarray experiments in minutes rather than hours AN - 20569617; 8084429 AB - MOTIVATION: The BioArray Software Environment (BASE) is a very popular MIAME-compliant, web-based microarray data repository. However in BASE, like in most other microarray data repositories, the experiment annotation and raw data uploading can be very timeconsuming, especially for large microarray experiments. RESULTS: We developed KUTE (Karmanos Universal daTabase for microarray Experiments), as a plug-in for BASE 2.0 that addresses these issues. KUTE provides an automatic experiment annotation feature and a completely redesigned data work-flow that dramatically reduce the human-computer interaction time. For instance, in BASE 2.0 a typical Affymetrix experiment involving 100 arrays required 4 h 30 min of user interaction time forexperiment annotation, and 45 min for data upload/download. In contrast, for the same experiment, KUTE required only 28 min of user interaction time for experiment annotation, and 3.3 min for data upload/download. AVAILABILITY: http://vortex.cs.wayne.edu/kute/index.html. JF - Bioinformatics AU - Draghici, Sorin AU - Tarca, Adi L AU - Yu, Longfei AU - Ethier, Stephen AU - Romero, Roberto AD - Department of Computer Science, Wayne State University, 431 State Hall, Detroit, MI 48202, Perinatology Research Branch-NIH/NICHD, 4 Brush, 3990 John R and Barbara Ann Karmanos Cancer Institute, 110 Warren Avenue Detroit, MI 48201, USA, sod@cs.wayne.edu Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 738 EP - 740 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 24 IS - 5 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Computer programs KW - software KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20569617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=KUTE-BASE%3A+storing%2C+downloading+and+exporting+MIAME-compliant+microarray+experiments+in+minutes+rather+than+hours&rft.au=Draghici%2C+Sorin%3BTarca%2C+Adi+L%3BYu%2C+Longfei%3BEthier%2C+Stephen%3BRomero%2C+Roberto&rft.aulast=Draghici&rft.aufirst=Sorin&rft.date=2008-03-01&rft.volume=24&rft.issue=5&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; software; Bioinformatics ER - TY - JOUR T1 - fdrMotif: identifying cis-elements by an EM algorithm coupled with false discovery rate control AN - 20568032; 8084408 AB - MOTIVATION: Most de novo motif identification methods optimize the motif model first and then separately test the statistical significance of the motif score. In the first stage, a motif abundance parameter needs to be specified or modeled. In the second stage, a Z-score or P-value is used as the test statistic. Error rates under multiple comparisons are not fully considered. METHODOLOGY: We propose a simple but novel approach, fdrMotif, that selects as many binding sites as possible while controlling a user-specified false discovery rate (FDR). Unlike existing iterative methods, fdrMotif combines model optimization [e.g. position weight matrix (PWM)] and significance testing at each step. By monitoring the proportion of binding sites selected in many sets of background sequences, fdrMotif controls the FDR in the original data. The model is then updated using an expectation (E)- and maximization (M)-like procedure. We propose a new normalization procedure in the E-step for updating the model. This process is repeated until either the model converges or the number of iterations exceeds a maximum. RESULTS: Simulation studies suggest that our normalization procedure assigns larger weights to the binding sites than do two other commonly used normalization procedures. Furthermore, fdrMotif requires only a user-specified FDR and an initial PWM. When tested on 542 high confidence experimental p53 binding loci, fdrMotif identified 569 p53 binding sites in 505 (93.2%) sequences. In comparison, MEME identified more binding sites but in fewer ChIP sequences than fdrMotif. When tested on 500 sets of simulated 'ChIP' sequences with embedded known p53 binding sites, fdrMotif, compared to MEME, has higher sensitivity with similar positive predictive value. Furthermore, fdrMotif is robust to noise: it selected nearly identical binding sites in data adulterated with 50% added background sequences and the unadulterated data. We suggest that fdrMotif represents an improvement over MEME. AVAILABILITY: C code can be found at: http://www.niehs.nih.gov/research/resources/software/fdrMotif/. Supplementary information: Supplementary data are available at http://www.niehs.nih.gov/research/resources/software/fdrMotif/ JF - Bioinformatics AU - Li, Leping AU - Bass, Robert L AU - Liang, Yu AD - Biostatistics Branch and Computational Biology Facility, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA, li3@niehs.nih.gov Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 629 EP - 636 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 24 IS - 5 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Statistics KW - Abundance KW - Algorithms KW - Statistical analysis KW - Bioinformatics KW - p53 protein KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20568032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=fdrMotif%3A+identifying+cis-elements+by+an+EM+algorithm+coupled+with+false+discovery+rate+control&rft.au=Li%2C+Leping%3BBass%2C+Robert+L%3BLiang%2C+Yu&rft.aulast=Li&rft.aufirst=Leping&rft.date=2008-03-01&rft.volume=24&rft.issue=5&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Statistics; Abundance; Statistical analysis; Algorithms; Bioinformatics; p53 protein ER - TY - JOUR T1 - Underestimation of Relative Risks by Standardized Incidence Ratios for AIDS-Related Cancers AN - 20562483; 9272828 AB - Purpose Registry-based studies provide valuable data regarding cancer risk among people with HIV/AIDS (PWHA). Such studies utilize the standardized incidence ratio (SIR) to estimate the relative risk (RR), an etiologically relevant measure. However, SIR may underestimate RR when HIV/AIDS prevalence in the general population or RR is high. We quantified the extent of this underestimation for 3 AIDS-related cancers: Kaposi sarcoma (KS), central nervous system non-Hodgkin lymphoma (CNS NHL) and cervical cancer. Methods We used data on cancer risk among PWHA from the U.S. HIV/AIDS Cancer Match Study. SIRs were compared with RRs estimated using two methods: (1) SIRs calculated using pre-AIDS era (1973-1979) cancer incidence rates (SIRpre-AIDS) and (2) SIRs calculated after subtraction of cancers known to be among PWHA from general population rates (SIRexclusion). Results For KS and CNS NHL, SIRs (117.8 and 133.9, respectively) calculated using overall general population rates substantially underestimated both SIRpre-AIDS (19,778 and 3,612, respectively) and SIRexclusion (657.7 and 536.4, respectively). In contrast, the extent of underestimation was negligible for cervical cancer (SIR = 4.9 vs. SIRexclusion = 5.1). For KS and CNS NHL, SIRs were higher in females than in males. However, SIRpre-AIDS and SIRexclusion estimates were more similar, indicating that SIR differences artifactually reflect differences in HIV/AIDS prevalence between males and females. For KS and CNS NHL, trends across calendar time were weaker in SIRs than in SIRpre-AIDS and SIRexclusion. Conclusion For KS and CNS NHL, SIRs substantially underestimate RRs. This underestimation arises from the exceptionally high relative risk of KS and CNS NHL among PWHA. SIRs must be interpreted cautiously when HIV/AIDS prevalence is high or varies across groups of interest. Key Words: HIV; AIDS; Kaposi Sarcoma; Non-Hodgkin Lymphoma; Cervical Cancer; SIR; RR; Bias Abbreviations: KS, Kaposi sarcoma; NHL, non-Hodgkin lymphoma; RR, relative risk; PWHA, persons with HIV/AIDS; SIR, standardized incidence ratio; PE, exposure prevalence; CNS NHL, central nervous system NHL; I0, incidence in non-HIV/AIDS population JF - Annals of Epidemiology AU - Chaturvedi, Anil K AU - Mbulaiteye, Sam M AU - Engels, Eric A AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, chaturva@mail.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 230 EP - 234 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 18 IS - 3 SN - 1047-2797, 1047-2797 KW - Risk Abstracts; Virology & AIDS Abstracts KW - non-Hodgkin's lymphoma KW - Risk assessment KW - Central nervous system KW - Acquired immune deficiency syndrome KW - Data processing KW - Cervical cancer KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - Sex differences KW - Cancer KW - USA KW - Human immunodeficiency virus KW - Risk factors KW - Sarcoma KW - Standards KW - Lymphoma KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20562483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Underestimation+of+Relative+Risks+by+Standardized+Incidence+Ratios+for+AIDS-Related+Cancers&rft.au=Chaturvedi%2C+Anil+K%3BMbulaiteye%2C+Sam+M%3BEngels%2C+Eric+A&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2008-03-01&rft.volume=18&rft.issue=3&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2007.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Central nervous system; Acquired immune deficiency syndrome; Data processing; Risk factors; Cervical cancer; Sarcoma; Sex differences; Lymphoma; non-Hodgkin's lymphoma; Human immunodeficiency virus; Standards; Cancer; USA; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir DO - http://dx.doi.org/10.1016/j.annepidem.2007.10.005 ER - TY - JOUR T1 - Organization of the core structure of the postsynaptic density AN - 20549353; 8089051 AB - Much is known about the composition and function of the postsynaptic density (PSD), but less is known about its molecular organization. We use EM tomography to delineate the organization of PSDs at glutamatergic synapses in rat hippocampal cultures. The core of the PSD is dominated by vertically oriented filaments, and ImmunoGold labeling shows that PSD-95 is a component of these filaments. Vertical filaments contact two types of transmembrane structures whose sizes and positions match those of glutamate receptors and intermesh with two types of horizontally oriented filaments lying 10-20 nm from the postsynaptic membrane. The longer horizontal filaments link adjacent NMDAR-type structures, whereas the smaller filaments link both NMDA- and AMPAR-type structures. The orthogonal, interlinked scaffold of filaments at the core of the PSD provides a structural basis for understanding dynamic aspects of postsynaptic function. JF - Proceedings of the National Academy of Sciences, USA AU - Chen, Xiaobing AU - Winters, Christine AU - Azzam, Rita AU - Li, Xiang AU - Galbraith, James A AU - Leapman, Richard D AU - Reese, Thomas S AD - Laboratory of Neurobiology and Electron Microscopy Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 4453 EP - 4458 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 11 SN - 0027-8424, 0027-8424 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20549353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Organization+of+the+core+structure+of+the+postsynaptic+density&rft.au=Chen%2C+Xiaobing%3BWinters%2C+Christine%3BAzzam%2C+Rita%3BLi%2C+Xiang%3BGalbraith%2C+James+A%3BLeapman%2C+Richard+D%3BReese%2C+Thomas+S&rft.aulast=Chen&rft.aufirst=Xiaobing&rft.date=2008-03-01&rft.volume=105&rft.issue=11&rft.spage=4453&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - caGrid 1.0: An Enterprise Grid Infrastructure for Biomedical Research AN - 20546284; 8086467 AB - OBJECTIVE: To develop software infrastructure that will provide support for discovery, characterization, integrated access, and management of diverse and disparate collections of information sources, analysis methods, and applications in biomedical research. DESIGN: An enterprise Grid software infrastructure, called caGrid version 1.0 (caGrid 1.0), has been developed as the core Grid architecture of the NCI-sponsored cancer Biomedical Informatics Grid (caBIG super(TM)) program. It is designed to support a wide range of use cases in basic, translational, and clinical research, including 1) discovery, 2) integrated and large-scale data analysis, and 3) coordinated study. MEASUREMENTS: The caGrid is built as a Grid software infrastructure and leverages Grid computing technologies and the Web Services Resource Framework standards. It provides a set of core services, toolkits for the development and deployment of new community provided services, and application programming interfaces for building client applications. RESULTS: The caGrid 1.0 was released to the caBIG community in December 2006. It is built on open source components and caGrid source code is publicly and freely available under a liberal open source license. The core software, associated tools, and documentation can be downloaded from the following URL: https://cabig.nci.nih.gov/workspaces/Architecture/caGrid. CONCLUSIONS: While caGrid 1.0 is designed to address use cases in cancer research, the requirements associated with discovery, analysis and integration of large scale data, and coordinated studies are common in other biomedical fields. In this respect, caGrid 1.0 is the realization of a framework that can benefit the entire biomedical community. JF - Journal of the American Medical Informatics Association AU - Oster, Scott AU - Langella, Stephen AU - Hastings, Shannon AU - Ervin, David AU - Madduri, Ravi AU - Phillips, Joshua AU - Kurc, Tahsin AU - Siebenlist, Frank AU - Covitz, Peter AU - Shanbhag, Krishnakant AU - Foster, Ian AU - Saltz, Joel AD - Department of Biomedical Informatics, The Ohio State University, Columbus, OH. Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, IL. National Cancer Institute Center for Bioinformatics, Rockville, MD. SemanticBits, Reston, VA Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 138 EP - 149 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 2 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Integration KW - Translation KW - software KW - Data processing KW - Bioinformatics KW - Cancer KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20546284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=caGrid+1.0%3A+An+Enterprise+Grid+Infrastructure+for+Biomedical+Research&rft.au=Oster%2C+Scott%3BLangella%2C+Stephen%3BHastings%2C+Shannon%3BErvin%2C+David%3BMadduri%2C+Ravi%3BPhillips%2C+Joshua%3BKurc%2C+Tahsin%3BSiebenlist%2C+Frank%3BCovitz%2C+Peter%3BShanbhag%2C+Krishnakant%3BFoster%2C+Ian%3BSaltz%2C+Joel&rft.aulast=Oster&rft.aufirst=Scott&rft.date=2008-03-01&rft.volume=15&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Translation; Integration; Computer programs; software; Data processing; Bioinformatics; Cancer ER - TY - JOUR T1 - The BRIDG Project: A Technical Report AN - 20545604; 8086466 AB - OBJECTIVES: The Biomedical Research Integrated Domain Group (BRIDG) project is a collaborative initiative between the National Cancer Institute (NCI), the Clinical Data Interchange Standards Consortium (CDISC), the Regulated Clinical Research Information Management Technical Committee (RCRIM TC) of Health Level 7 (HL7), and the Food and Drug Administration (FDA) to develop a model of the shared understanding of the semantics of clinical research. DESIGN: The BRIDG project is based on open-source collaborative principles and an implementation-independent, use-case driven approach to model development. In the BRIDG model, declarative and procedural knowledge are represented using the Unified Modeling Language (UML) class, activity and state diagrams. MEASUREMENTS: The BRIDG model currently contains harmonized semantics from four project use cases: the caXchange project and the patient study calendar project from caBIG super(TM); the standard data tabular model (SDTM) from CDISC; and the regulated products submission model (RPS) from HL7. Scalable harmonization processes have been developed to expand the model with content from additional use cases. RESULTS: The first official release of the BRIDG model was published in June 2007. Use of the BRIDG model by the NCI has supported the rapid development of semantic interoperability across applications within the caBIG super(TM) program. CONCLUSIONS: The BRIDG project has brought together different standards communities to clarify the semantics of clinical research across pharmaceutical, regulatory, and research organizations. Currently, the NCI uses the BRIDG model to support interoperable application development in the caBIG super(TM), and CDISC and HL7 are using the BRIDG model to support standards development. JF - Journal of the American Medical Informatics Association AU - Fridsma, Douglas B AU - Evans, Julie AU - Hastak, Smita AU - Mead, Charles N AD - Department of Biomedical Informatics, Arizona State University, Phoenix, AZ. Clinical Data Interchange Standards Consortium, Washington DC. ScenPro Inc., Washington DC. Booz Allen Hamilton/National Cancer Institute, Washington DC Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 130 EP - 137 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 15 IS - 2 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Pharmaceuticals KW - Language KW - Development KW - Models KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20545604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=The+BRIDG+Project%3A+A+Technical+Report&rft.au=Fridsma%2C+Douglas+B%3BEvans%2C+Julie%3BHastak%2C+Smita%3BMead%2C+Charles+N&rft.aulast=Fridsma&rft.aufirst=Douglas&rft.date=2008-03-01&rft.volume=15&rft.issue=2&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Pharmaceuticals; Language; Development; Semantics; Models ER - TY - JOUR T1 - Consistent blind protein structure generation from NMR chemical shift data AN - 20542672; 8089095 AB - Protein NMR chemical shifts are highly sensitive to local structure. A robust protocol is described that exploits this relation for de novo protein structure generation, using as input experimental parameters the super(13)C super( alpha ), super(13)C super( beta ), super(13)C', super(15)N, super(1)H super( alpha ) and super(1)H super(N) NMR chemical shifts. These shifts are generally available at the early stage of the traditional NMR structure determination process, before the collection and analysis of structural restraints. The chemical shift based structure determination protocol uses an empirically optimized procedure to select protein fragments from the Protein Data Bank, in conjunction with the standard ROSETTA Monte Carlo assembly and relaxation methods. Evaluation of 16 proteins, varying in size from 56 to 129 residues, yielded full-atom models that have 0.7-1.8 Aa root mean square deviations for the backbone atoms relative to the experimentally determined x-ray or NMR structures. The strategy also has been successfully applied in a blind manner to nine protein targets with molecular masses up to 15.4 kDa, whose conventional NMR structure determination was conducted in parallel by the Northeast Structural Genomics Consortium. This protocol potentially provides a new direction for high-throughput NMR structure determination. JF - Proceedings of the National Academy of Sciences, USA AU - Shen, Yang AU - Lange, Oliver AU - Delaglio, Frank AU - Rossi, Paolo AU - Aramini, James M AU - Liu, Gaohua AU - Eletsky, Alexander AU - Wu, Yibing AU - Singarapu, Kiran K AU - Lemak, Alexander AU - Ignatchenko, Alexandr AU - Arrowsmith, Cheryl H AU - Szyperski, Thomas AU - Montelione, Gaetano T AU - Baker, David AU - Bax, Ad AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 4685 EP - 4690 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 12 SN - 0027-8424, 0027-8424 KW - Sustainability Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20542672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Consistent+blind+protein+structure+generation+from+NMR+chemical+shift+data&rft.au=Shen%2C+Yang%3BLange%2C+Oliver%3BDelaglio%2C+Frank%3BRossi%2C+Paolo%3BAramini%2C+James+M%3BLiu%2C+Gaohua%3BEletsky%2C+Alexander%3BWu%2C+Yibing%3BSingarapu%2C+Kiran+K%3BLemak%2C+Alexander%3BIgnatchenko%2C+Alexandr%3BArrowsmith%2C+Cheryl+H%3BSzyperski%2C+Thomas%3BMontelione%2C+Gaetano+T%3BBaker%2C+David%3BBax%2C+Ad&rft.aulast=Shen&rft.aufirst=Yang&rft.date=2008-03-01&rft.volume=105&rft.issue=12&rft.spage=4685&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Developing Smoking Cessation Programs for Chronically Ill Teens: Lessons Learned from Research with Healthy Adolescent Smokers AN - 20542343; 8040452 AB - OBJECTIVE:Medically fragile teens who smoke need access to smoking cessation programs, because they are at even higher risk than their healthy peers for smoking-related complications. METHODS:To date, no studies on the outcome of smoking cessation programs for medically ill teens have been conducted. To suggest directions for future research, we turn to the literature on smoking cessation in the general population of teens and occasionally to the literature on adult smokers. RESULTS:Four areas are explored: (a) the prevalence of unaided cessation in healthy teens; (b) the outcomes of various treatments for smoking cessation in healthy adolescents; (c) special issues that should be considered when designing programs for medically ill teens; and (d) lessons learned from previous research. CONCLUSIONS:Medically ill teens face a number of medical, emotional, social, and developmental challenges that can affect the quitting process. Research is sorely needed to address the unique needs of this population. JF - Journal of Pediatric Psychology AU - Robinson, Leslie A AU - Emmons, Karen M AU - Moolchan, Eric T AU - Ostroff, Jamie S AD - Department of Psychology, The University of Memphis, Dana-Farber Cancer Institute and Harvard School of Public Health, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, and Department of Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Center Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 133 EP - 144 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 33 IS - 2 SN - 0146-8693, 0146-8693 KW - Risk Abstracts KW - Smoking KW - Prevention KW - Adolescents KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20542343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pediatric+Psychology&rft.atitle=Developing+Smoking+Cessation+Programs+for+Chronically+Ill+Teens%3A+Lessons+Learned+from+Research+with+Healthy+Adolescent+Smokers&rft.au=Robinson%2C+Leslie+A%3BEmmons%2C+Karen+M%3BMoolchan%2C+Eric+T%3BOstroff%2C+Jamie+S&rft.aulast=Robinson&rft.aufirst=Leslie&rft.date=2008-03-01&rft.volume=33&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pediatric+Psychology&rft.issn=01468693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Smoking; Prevention; Adolescents ER - TY - JOUR T1 - Constitutive Expression of IL-7 Receptor alpha Does Not Support Increased Expansion or Prevent Contraction of Antigen-Specific CD4 or CD8 T Cells following Listeria monocytogenes Infection AN - 20532901; 8039697 AB - Expression of IL-7R alpha (CD127) has been suggested as a major determinant in the survival of memory T cell precursors. We investigated whether constitutive expression of IL-7R alpha on T cells increased expansion and/or decreased contraction of endogenous Ag-specific CD4 and CD8 T cells following infection with Listeria monocytogenes. The results indicate that constitutive expression of IL-7R alpha alone was not enough to impart an expansion or survival advantage to CD8 T cells responding to infection, and did not increase memory CD8 T cell numbers over those observed in wild-type controls. Constitutive expression of IL-7R alpha did allow for slightly prolonged expansion of Ag-specific CD4 T cells; however, it did not alter the contraction phase or protect against the waning of memory T cell numbers at later times after infection. Memory CD4 and CD8 T cells generated in IL-7R alpha transgenic mice expanded similarly to wild-type T cells after secondary infection, and immunized IL-7R alpha transgenic mice were fully protected against lethal bacterial challenge demonstrating that constitutive expression of IL-7R alpha does not impair, or markedly improve memory/secondary effector T cell function. These results indicate that expression of IL-7R alpha alone does not support increased survival of effector Ag-specific CD4 or CD8 T cells into the memory phase following bacterial infection. JF - Journal of Immunology AU - Haring, Jodie S AU - Jing, Xuefang AU - Bollenbacher-Reilley, Julie AU - Xue, Hai-Hui AU - Leonard, Warren J AU - Harty, John T AD - Department of Microbiology, Carver School of Medicine and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242. Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20824 Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 2855 EP - 2862 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 5 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell survival KW - Listeria monocytogenes KW - Interleukin 7 KW - CD4 antigen KW - Lymphocytes T KW - Memory cells KW - Immunological memory KW - CD8 antigen KW - Secondary infection KW - Transgenic mice KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20532901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Constitutive+Expression+of+IL-7+Receptor+alpha+Does+Not+Support+Increased+Expansion+or+Prevent+Contraction+of+Antigen-Specific+CD4+or+CD8+T+Cells+following+Listeria+monocytogenes+Infection&rft.au=Haring%2C+Jodie+S%3BJing%2C+Xuefang%3BBollenbacher-Reilley%2C+Julie%3BXue%2C+Hai-Hui%3BLeonard%2C+Warren+J%3BHarty%2C+John+T&rft.aulast=Haring&rft.aufirst=Jodie&rft.date=2008-03-01&rft.volume=180&rft.issue=5&rft.spage=2855&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Interleukin 7; CD4 antigen; Immunological memory; Memory cells; Lymphocytes T; Secondary infection; CD8 antigen; Transgenic mice; Listeria monocytogenes ER - TY - JOUR T1 - A Chemokine-Degrading Extracellular Protease Made by Group A Streptococcus Alters Pathogenesis by Enhancing Evasion of the Innate Immune Response AN - 20529955; 8037573 AB - Circumvention of the host innate immune response is critical for bacterial pathogens to infect and cause disease. Here we demonstrate that the group A Streptococcus (GAS; Streptococcus pyogenes) protease SpyCEP (S. pyogenes cell envelope protease) cleaves granulocyte chemotactic protein 2 (GCP-2) and growth-related oncogene alpha (GRO alpha ), two potent chemokines made abundantly in human tonsils. Cleavage of GCP-2 and GRO alpha by SpyCEP abrogated their abilities to prime neutrophils for activation, detrimentally altering the innate immune response. SpyCEP expression is negatively regulated by the signal transduction system CovR/S. Purified recombinant CovR bound the spyCEP gene promoter region in vitro, indicating direct regulation. Immunoreactive SpyCEP protein was present in the culture supernatants of covR/S mutant GAS strains but not in supernatants from wild-type strains. However, wild-type GAS strains do express SpyCEP, where it is localized to the cell wall. Strain MGAS2221, an organism representative of the highly virulent and globally disseminated M1T1 GAS clone, differed significantly from its isogenic spyCEP mutant derivative strain in a mouse soft tissue infection model. Interestingly, and in contrast to previous studies, the isogenic mutant strain generated lesions of larger size than those formed following infection with the parent strain. The data indicate that SpyCEP contributes to GAS virulence in a strain- and disease-dependent manner. JF - Infection and Immunity AU - Sumby, Paul AU - Zhang, Shizhen AU - Whitney, Adeline R AU - Falugi, Fabiana AU - Grandi, Guido AU - Graviss, Edward A AU - DeLeo, Frank R AU - Musser, James M AD - Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas 77030. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy. Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 978 EP - 985 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 3 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Chemokines KW - Cell envelopes KW - Animal models KW - Leukocytes (neutrophilic) KW - Cell culture KW - Pathogens KW - Infection KW - Streptococcus pyogenes KW - Cell activation KW - Virulence KW - Leukocytes (granulocytic) KW - Promoters KW - Gro protein KW - Tonsil KW - Proteinase KW - Immune response KW - Soft tissues KW - Signal transduction KW - Cell walls KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20529955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=A+Chemokine-Degrading+Extracellular+Protease+Made+by+Group+A+Streptococcus+Alters+Pathogenesis+by+Enhancing+Evasion+of+the+Innate+Immune+Response&rft.au=Sumby%2C+Paul%3BZhang%2C+Shizhen%3BWhitney%2C+Adeline+R%3BFalugi%2C+Fabiana%3BGrandi%2C+Guido%3BGraviss%2C+Edward+A%3BDeLeo%2C+Frank+R%3BMusser%2C+James+M&rft.aulast=Sumby&rft.aufirst=Paul&rft.date=2008-03-01&rft.volume=76&rft.issue=3&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chemokines; Cell envelopes; Leukocytes (neutrophilic); Animal models; Cell culture; Pathogens; Infection; Cell activation; Virulence; Promoters; Leukocytes (granulocytic); Gro protein; Tonsil; Proteinase; Immune response; Soft tissues; Cell walls; Signal transduction; Streptococcus pyogenes ER - TY - JOUR T1 - Role of Accessory DNA Polymerases in DNA Replication in Escherichia coli: Analysis of the dnaX36 Mutator Mutant AN - 20528205; 8038199 AB - The dnaX36(TS) mutant of Escherichia coli confers a distinct mutator phenotype characterized by enhancement of transversion base substitutions and certain (-1) frameshift mutations. Here, we have further investigated the possible mechanism(s) underlying this mutator effect, focusing in particular on the role of the various E. coli DNA polymerases. The dnaX gene encodes the tau subunit of DNA polymerase III (Pol III) holoenzyme, the enzyme responsible for replication of the bacterial chromosome. The dnaX36 defect resides in the C-terminal domain V of tau , essential for interaction of tau with the alpha (polymerase) subunit, suggesting that the mutator phenotype is caused by an impaired or altered alpha - tau interaction. We previously proposed that the mutator activity results from aberrant processing of terminal mismatches created by Pol III insertion errors. The present results, including lack of interaction of dnaX36 with mutM, mutY, and recA defects, support our assumption that dnaX36-mediated mutations originate as errors of replication rather than DNA damage-related events. Second, an important role is described for DNA Pol II and Pol IV in preventing and producing, respectively, the mutations. In the system used, a high fraction of the mutations is dependent on the action of Pol IV in a (dinB) gene dosage-dependent manner. However, an even larger but opposing role is deduced for Pol II, revealing Pol II to be a major editor of Pol III mediated replication errors. Overall, the results provide insight into the interplay of the various DNA polymerases, and of tau subunit, in securing a high fidelity of replication. JF - Journal of Bacteriology AU - Gawel, Damian AU - Pham, Phuong T AU - Fijalkowska, Iwona J AU - Jonczyk, Piotr AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland Y1 - 2008/03/01/ PY - 2008 DA - 2008 Mar 01 SP - 1730 EP - 1742 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 5 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - DNA biosynthesis KW - Fidelity KW - Chromosomes KW - Frameshift mutation KW - dinB gene KW - Replication KW - DNA-directed DNA polymerase KW - Escherichia coli KW - Enzymes KW - RecA protein KW - Transversion KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20528205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+Accessory+DNA+Polymerases+in+DNA+Replication+in+Escherichia+coli%3A+Analysis+of+the+dnaX36+Mutator+Mutant&rft.au=Gawel%2C+Damian%3BPham%2C+Phuong+T%3BFijalkowska%2C+Iwona+J%3BJonczyk%2C+Piotr%3BSchaaper%2C+Roel+M&rft.aulast=Gawel&rft.aufirst=Damian&rft.date=2008-03-01&rft.volume=190&rft.issue=5&rft.spage=1730&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Chromosomes; Fidelity; dinB gene; Frameshift mutation; Replication; DNA-directed DNA polymerase; Enzymes; Transversion; RecA protein; Escherichia coli ER - TY - JOUR T1 - Mechanisms of Resistance to Daptomycin in Enterococcus faecium AN - 20026947; 8083395 AB - In this study, we investigated the clonal emergence of daptomycin-resistant Enterococcus faecium strains isolated from a patient with leukocyte adhesion deficiency syndrome. The resistance mechanism in these strains is independent of either equivalent point mutations previously described for Staphylococcus aureus or daptomycin inactivation mechanisms identified in soil bacteria. JF - Antimicrobial Agents & Chemotherapy AU - Montero, Clemente I AU - Stock, Frida AU - Murray, Patrick R AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Drive, MSC 1508, Bethesda, Maryland 20892-1508 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1167 EP - 1170 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Leukocytes KW - Point mutation KW - Staphylococcus aureus KW - daptomycin KW - Enterococcus faecium KW - Soil microorganisms KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20026947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Mechanisms+of+Resistance+to+Daptomycin+in+Enterococcus+faecium&rft.au=Montero%2C+Clemente+I%3BStock%2C+Frida%3BMurray%2C+Patrick+R&rft.aulast=Montero&rft.aufirst=Clemente&rft.date=2008-03-01&rft.volume=52&rft.issue=3&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Point mutation; Leukocytes; daptomycin; Soil microorganisms; Staphylococcus aureus; Enterococcus faecium ER - TY - JOUR T1 - Inhibition of ABC Transporters Abolishes Antimony Resistance in Leishmania Infection AN - 20003636; 8083379 AB - The emergence of antimony (Sb) resistance has jeopardized the treatment of visceral leishmaniasis in various countries. Previous studies have considered the part played by leishmanial parasites in antimony resistance, but the involvement of host factors in the clinical scenario remained to be investigated. Here we show that unlike infection with Sb-sensitive (Sb super(s)) Leishmania donovani, infection with Sb-resistant (Sb super(r)) L. donovani induces the upregulation of multidrug resistance-associated protein 1 (MRP1) and permeability glycoprotein (P-gp) in host cells, resulting in a nonaccumulation of intracellular Sb following treatment with sodium antimony gluconate (SAG) favoring parasite replication. The inhibition of MRP1 and P-gp with resistance-modifying agents such as lovastatin allows Sb accumulation and parasite killing within macrophages and offers protection in an animal model in which infection with Sb super(r) L. donovani is otherwise lethal. The occurrence of a similar scenario in clinical cases is supported by the findings that unlike monocytes from SAG-sensitive kala-azar (KA) patients, monocytes from SAG-unresponsive KA patients overexpress P-gp and MRP1 and fail to accumulate Sb following in vitro SAG treatment unless pretreated with inhibitors of ABC transporters. Thus, the expression status of MRP1 and P-gp in blood monocytes may be used as a diagnostic marker for Sb resistance and the treatment strategy can be designed accordingly. Our results also indicate that lovastatin, which can inhibit both P-gp and MRP1, might be beneficial for reverting Sb resistance in leishmaniasis as well as drug resistance in other clinical situations, including cancer. JF - Antimicrobial Agents & Chemotherapy AU - Mookerjee Basu, Jayati AU - Mookerjee, Ananda AU - Banerjee, Rajdeep AU - Saha, Manik AU - Singh, Subhankar AU - Naskar, Ksudiram AU - Tripathy, Gayetri AU - Sinha, Prabhat K AU - Pandey, Krishna AU - Sundar, Shyam AU - Bimal, Sanjeev AU - Das, Pradip K AU - Choudhuri, Soumitra K AU - Roy, Syamal AD - Department of Immunology, Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Kolkata 700032, WB, India. Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, Kolkata 700026, WB, India. Rajendra Memorial Research Institute, Patna 800007, India. Geological Survey of India, Kolkata, India. Department of Medicine, Institute of Medical Sciences, Benaras Hindu University, Varanasi, India Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1080 EP - 1093 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Macrophages KW - Parasites KW - Replication KW - ABC transporter KW - Visceral leishmaniasis KW - Drug resistance KW - Animal models KW - Infection KW - Cancer KW - Leishmania donovani KW - Sodium KW - Blood KW - Permeability KW - Antimony KW - MRP protein KW - Monocytes KW - Glycoproteins KW - Lovastatin KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20003636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Inhibition+of+ABC+Transporters+Abolishes+Antimony+Resistance+in+Leishmania+Infection&rft.au=Mookerjee+Basu%2C+Jayati%3BMookerjee%2C+Ananda%3BBanerjee%2C+Rajdeep%3BSaha%2C+Manik%3BSingh%2C+Subhankar%3BNaskar%2C+Ksudiram%3BTripathy%2C+Gayetri%3BSinha%2C+Prabhat+K%3BPandey%2C+Krishna%3BSundar%2C+Shyam%3BBimal%2C+Sanjeev%3BDas%2C+Pradip+K%3BChoudhuri%2C+Soumitra+K%3BRoy%2C+Syamal&rft.aulast=Mookerjee+Basu&rft.aufirst=Jayati&rft.date=2008-03-01&rft.volume=52&rft.issue=3&rft.spage=1080&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Parasites; ABC transporter; Replication; Drug resistance; Visceral leishmaniasis; Animal models; Infection; Cancer; Sodium; Permeability; Blood; MRP protein; Antimony; Glycoproteins; Monocytes; Lovastatin; Leishmania donovani ER - TY - JOUR T1 - Sorting Behavior of a Transgenic Erythropoietin-Growth Hormone Fusion Protein in Murine Salivary Glands AN - 19891861; 8128020 AB - Salivary glands are useful gene transfer target sites for the production of therapeutic proteins, and can secrete proteins into both saliva and the bloodstream. The mechanisms involved in this differential protein sorting are not well understood, although it is believed, at least in part, to be based on the amino acid sequence of the encoded protein. We hypothesized that a transgenic protein, human erythropoietin (hEpo), normally sorted from murine salivary glands into the bloodstream, could be redirected into saliva by fusing it with human growth hormone (hGH). After transfection, the hEpo-hGH fusion protein was expressed and glycosy-lated in both HEK 293 and A5 cells. When packaged in an adenovirus serotype 5 vector and delivered to murine submandibular cells in vivo via retroductal cannulation, the hEpo-hGH fusion protein was also expressed, albeit at similar to 26% of the levels of hEpo expression. Importantly, in multiple experiments with different cohorts of mice, the hEpo-hGH fusion protein was sorted more frequently into saliva, versus the bloodstream, than was the hEpo protein (p < 0.001). These studies show it is possible to redirect the secretion of a transgenic constitutive pathway protein from salivary gland cells after gene transfer in vivo, a finding that may facilitate developing novel treatments for certain upper gastrointestinal tract disorders. JF - Human Gene Therapy AU - Samuni, Y AU - Cawley, N X AU - Zheng, C AU - Cotrim, A P AU - Loh, Y P AU - Baum, B J AD - Bldg. 10, Room 1N113, MSC-1190, GTTB/NIDCR/NIH, 10 Center Drive, Bethesda, MD 20892-1190, USA, bbaum@dir.nidcr.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 279 EP - 286 VL - 19 IS - 3 SN - 1043-0342, 1043-0342 KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Growth hormone KW - Serotypes KW - Gene therapy KW - Secretion KW - Adenovirus KW - Salivary gland KW - Hormones KW - Expression vectors KW - Erythropoietin KW - Transfection KW - Gastrointestinal tract KW - Saliva KW - Fusion protein KW - Cannulation KW - Amino acid sequence KW - W 30905:Medical Applications KW - N 14815:Nucleotide Sequence KW - G 07870:Mammals KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Sorting+Behavior+of+a+Transgenic+Erythropoietin-Growth+Hormone+Fusion+Protein+in+Murine+Salivary+Glands&rft.au=Samuni%2C+Y%3BCawley%2C+N+X%3BZheng%2C+C%3BCotrim%2C+A+P%3BLoh%2C+Y+P%3BBaum%2C+B+J&rft.aulast=Samuni&rft.aufirst=Y&rft.date=2008-03-01&rft.volume=19&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2007.0136 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Growth hormone; Serotypes; Gene therapy; Secretion; Salivary gland; Hormones; Expression vectors; Erythropoietin; Transfection; Fusion protein; Saliva; Gastrointestinal tract; Cannulation; Amino acid sequence; Adenovirus DO - http://dx.doi.org/10.1089/hum.2007.0136 ER - TY - JOUR T1 - Cripto-1 Alters Keratinocyte Differentiation via Blockade of Transforming Growth Factor- beta 1 Signaling: Role in Skin Carcinogenesis AN - 19885837; 8088429 AB - Cripto-1 is an epidermal growth factor-Cripto/FRL1/Cryptic family member that plays a role in early embryogenesis as a coreceptor for Nodal and is overexpressed in human tumors. Here we report that in the two-stage mouse skin carcinogenesis model, Cripto-1 is highly up-regulated in tumor promoter-treated normal skin and in benign papillomas. Treatment of primary mouse keratinocytes with Cripto-1 stimulated proliferation and induced expression of keratin 8 but blocked induction of the normal epidermal differentiation marker keratin 1, changes that are hallmarks of tumor progression in squamous cancer. Chemical or genetic blockade of the transforming growth factor (TGF)- beta 1 signaling pathway using the ALK5 kinase inhibitor SB431542 and dominant negative TGF- beta type II receptor, respectively, had similar effects on keratinocyte differentiation. Our results show that Cripto-1 could block TGF- beta 1 receptor binding, phosphorylation of Smad2 and Smad3, TGF- beta -responsive luciferase reporter activity, and TGF- beta 1-mediated senescence of keratinocytes. We suggest that inhibition of TGF- beta 1 by Cripto-1 may play an important role in altering the differentiation state of keratinocytes and promoting outgrowth of squamous tumors in the mouse epidermis. (Mol Cancer Res 2008; 6(3):509-16) JF - Molecular Cancer Research AU - Shukla, Anjali AU - Ho, Yan AU - Liu, Xin AU - Ryscavage, Andrew AU - Glick, Adam B AD - Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland and Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 509 EP - 516 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 3 SN - 1541-7786, 1541-7786 KW - Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - Transforming growth factor- beta 1 KW - Skin KW - Smad2 protein KW - Animal models KW - Tumors KW - Cancer KW - Differentiation KW - Epidermis KW - Embryogenesis KW - Keratin KW - Phosphorylation KW - Transforming growth factor- beta KW - Carcinogenesis KW - Smad3 protein KW - Senescence KW - Keratinocytes KW - Papilloma KW - Signal transduction KW - Benign KW - B 26620:Serine-Threonine Kinase Activity KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19885837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Research&rft.atitle=Cripto-1+Alters+Keratinocyte+Differentiation+via+Blockade+of+Transforming+Growth+Factor-+beta+1+Signaling%3A+Role+in+Skin+Carcinogenesis&rft.au=Shukla%2C+Anjali%3BHo%2C+Yan%3BLiu%2C+Xin%3BRyscavage%2C+Andrew%3BGlick%2C+Adam+B&rft.aulast=Shukla&rft.aufirst=Anjali&rft.date=2008-03-01&rft.volume=6&rft.issue=3&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Research&rft.issn=15417786&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transforming growth factor- beta 1; Skin; Animal models; Smad2 protein; Tumors; Cancer; Epidermis; Differentiation; Embryogenesis; Keratin; Phosphorylation; Smad3 protein; Carcinogenesis; Transforming growth factor- beta; Senescence; Keratinocytes; Papilloma; Benign; Signal transduction ER - TY - JOUR T1 - Inverse polarization transfer for detecting in vivo super(13)C magnetization transfer effect of specific enzyme reactions in super(1)H spectra AN - 19801800; 8585945 AB - The wide chemical shift dispersion and long T sub(1) of super(13)C have allowed determination of in vivo magnetization transfer effects caused by aspartate aminotransferase and lactate dehydrogenase reactions using super(13)C magnetic resonance spectroscopy. In this report, we demonstrate that these effects can be observed in the proton spectra by transferring the equilibrium magnetization of super(13)C via the one-bond scalar coupling between super(13)C and super(1)H using an inverse insensitive nuclei enhanced by polarization transfer-based heteronuclear polarization transfer method. This inverse method allows a combination of the advantages of the long super(13)C T sub(1) for maximum magnetization transfer and the high sensitivity of proton detection. The feasibility of this in vivo inverse polarization transfer approach was evaluated for detecting the super(13)C magnetization transfer effect of aspartate aminotransferase and lactate dehydrogenase reactions from a 72.5- mu l voxel in the rat brain at 11.7 T. JF - Magnetic Resonance Imaging AU - Xu, Su AU - Yang, Jehoon AU - Shen, Jun AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892-1527, USA, shenj@intra.nimh.nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 413 EP - 419 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 3 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Proton detection KW - Carbon-13 KW - Magnetization transfer effect KW - Protons KW - Aspartate aminotransferase KW - Magnetic resonance spectroscopy KW - Magnetic resonance imaging KW - Brain KW - Enzymes KW - Polarization KW - L-Lactate dehydrogenase KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19801800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Inverse+polarization+transfer+for+detecting+in+vivo+super%2813%29C+magnetization+transfer+effect+of+specific+enzyme+reactions+in+super%281%29H+spectra&rft.au=Xu%2C+Su%3BYang%2C+Jehoon%3BShen%2C+Jun&rft.aulast=Xu&rft.aufirst=Su&rft.date=2008-03-01&rft.volume=26&rft.issue=3&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2007.07.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Aspartate aminotransferase; Protons; Magnetic resonance spectroscopy; Magnetic resonance imaging; Brain; Enzymes; Polarization; L-Lactate dehydrogenase DO - http://dx.doi.org/10.1016/j.mri.2007.07.010 ER - TY - JOUR T1 - Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus AN - 19711320; 8089037 AB - The JFH1 strain of hepatitis C virus (HCV) is unique among HCV isolates, in that the wild-type virus can traverse the entire replication cycle in cultured cells. However, without adaptive mutations, only low levels of infectious virus are produced. In the present study, the effects of five mutations that were selected during serial passage in Huh-7.5 cells were studied. Recombinant genomes containing all five mutations produced 3-4 logs more infectious virions than did wild type. Neither a coding mutation in NS5A nor a silent mutation in E2 was adaptive, whereas coding mutations in E2, p7, and NS2 all increased virus production. A single-cycle replication assay in CD81-deficient cells was developed to study more precisely the effect of the adaptive mutations. The E2 mutation had minimal effect on the amount of infectious virus released but probably enhanced entry into cells. In contrast, both the p7 and NS2 mutations independently increased the amount of virus released. JF - Proceedings of the National Academy of Sciences, USA AU - Russell, Rodney S AU - Meunier, Jean-Christophe AU - Takikawa, Shingo AU - Faulk, Kristina AU - Engle, Ronald E AU - Bukh, Jens AU - Purcell, Robert H AU - Emerson, Suzanne U AD - Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 4370 EP - 4375 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 11 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Genetics Abstracts KW - Genomes KW - Virions KW - Hepatitis C virus KW - Replication KW - Mutation KW - W 30925:Genetic Engineering KW - V 22300:Methods KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Advantages+of+a+single-cycle+production+assay+to+study+cell+culture-adaptive+mutations+of+hepatitis+C+virus&rft.au=Russell%2C+Rodney+S%3BMeunier%2C+Jean-Christophe%3BTakikawa%2C+Shingo%3BFaulk%2C+Kristina%3BEngle%2C+Ronald+E%3BBukh%2C+Jens%3BPurcell%2C+Robert+H%3BEmerson%2C+Suzanne+U&rft.aulast=Russell&rft.aufirst=Rodney&rft.date=2008-03-01&rft.volume=105&rft.issue=11&rft.spage=4370&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virions; Genomes; Replication; Mutation; Hepatitis C virus ER - TY - JOUR T1 - Estrogen Induces Estrogen-related Receptor alpha Gene Expression and Chromatin Structural Changes in Estrogen Receptor (ER)-positive and ER-negative Breast Cancer Cells AN - 19710099; 8086660 AB - Estrogen-related receptor alpha (ERR alpha ), a member of the nuclear receptor superfamily, is closely related to the estrogen receptors (ER alpha and ER beta ). The ERR alpha gene is estrogen-responsive in several mouse tissues and cell lines, and a multiple hormone-response element (MHRE) in the promoter is an important regulatory region for estrogen-induced ERR alpha gene expression. ERR alpha was recently shown to be a negative prognostic factor for breast cancer survival, with its expression being highest in cancer cells lacking functional ER alpha . The contribution of ERR alpha in breast cancer progression remains unknown but may have important clinical implications. In this study, we investigated ERR alpha gene expression and chromatin structural changes under the influence of 17 beta -estradiol in both ER-positive MCF-7 and ER-negative SKBR3 breast cancer cells. We mapped the nucleosome positions of the ERR alpha promoter around the MHRE region and found that the MHRE resides within a single nucleosome. Local chromatin structure of the MHRE exhibited increased restriction enzyme hypersensitivity and enhanced histone H3 and H4 acetylation upon estrogen treatment. Interestingly, estrogen-induced chromatin structural changes could be repressed by estrogen antagonist ICI 182 780 in MCF-7 cells yet were enhanced in SKBR3 cells. We demonstrated, using chromatin immunoprecipitation assays, that 17 beta -estradiol induces ERR alpha gene expression in MCF-7 cells through active recruitment of co-activators and release of co-repressors when ERR alpha and AP1 bind and ER alpha is tethered to the MHRE. We also found that this estrogen effect requires the MAPK signaling pathway in both cell lines. JF - Journal of Biological Chemistry AU - Hu, Peng AU - Kinyamu, HKarimi AU - Wang, Liangli AU - Martin, Jessica AU - Archer, Trevor K AU - Teng, Christina AD - Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology and Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 6752 EP - 6763 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 11 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts; Genetics Abstracts KW - Cell survival KW - MAP kinase KW - Chromatin KW - Regulatory sequences KW - Nuclear receptors KW - Immunoprecipitation KW - Enzymes KW - Gene expression KW - Acetylation KW - Promoters KW - Nucleosomes KW - Hypersensitivity KW - 17 beta -Estradiol KW - Breast cancer KW - Histone H3 KW - Estrogen receptors KW - Signal transduction KW - B 26630:Nuclear & DNA-binding proteins KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Estrogen+Induces+Estrogen-related+Receptor+alpha+Gene+Expression+and+Chromatin+Structural+Changes+in+Estrogen+Receptor+%28ER%29-positive+and+ER-negative+Breast+Cancer+Cells&rft.au=Hu%2C+Peng%3BKinyamu%2C+HKarimi%3BWang%2C+Liangli%3BMartin%2C+Jessica%3BArcher%2C+Trevor+K%3BTeng%2C+Christina&rft.aulast=Hu&rft.aufirst=Peng&rft.date=2008-03-01&rft.volume=283&rft.issue=11&rft.spage=6752&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; MAP kinase; Chromatin; Nuclear receptors; Regulatory sequences; Immunoprecipitation; Enzymes; Gene expression; Promoters; Acetylation; Hypersensitivity; Nucleosomes; Breast cancer; 17 beta -Estradiol; Histone H3; Estrogen receptors; Signal transduction ER - TY - JOUR T1 - An NF-[kappa]B gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia AN - 19706250; 8112333 AB - Kaposi's sarcoma (KS) is the most frequent AIDS-associated malignancy, etiologically linked to the infection with the human herpesvirus 8 (HHV- 8/KSHV). This member of the [gamma]-herpesviridae family encodes 81 open reading frames, several bearing oncogenic potential. A constitutively active virally encoded G protein-coupled receptor (vGPCR) readily induces KS-like lesions when expressed in endothelial cells in vivo, and unmasks the oncogenic potential of other HHV-8 genes in a paracrine fashion. How vGPCR causes endothelial cell transformation is still not fully understood. Using full-genome microarray analysis we show here that the expression of nuclear factor-[kappa]B (NF-[kappa]B)-regulated genes is a prominent feature triggered by vGPCR in cells expressing this viral oncogene and in cells exposed to vGPCR-induced secretions, thus mimicking its paracrine effect. Indeed, vGPCR activates the NF-[kappa]B pathway potently, and NF-[kappa]B activation is a hallmark of both human and experimental KS. Of interest, whereas constitutive NF-[kappa]B signaling is not sufficient to promote endothelial cells transformation, NF-[kappa]B function is strictly required for vGPCR-induced direct and paracrine neoplasia. Taken together, these results strongly support the role of NF-[kappa]B regulated genes in KS pathogenesis, thus providing the rationale for the development of novel mechanism-based therapies for this angioproliferative disease. JF - Oncogene AU - Martin, D AU - Galisteo, R AU - Ji, Y AU - Montaner, S AU - Gutkind, J S AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA, sg39v@nih.gov Y1 - 2008/03// PY - 2008 DA - Mar 2008 SP - 1844 EP - 1852 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 12 IS - 13 SN - 0950-9232, 0950-9232 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Virology & AIDS Abstracts; Oncogenes & Growth Factors Abstracts KW - G proteins KW - signal transduction KW - G protein-coupled receptors KW - angiosarcoma KW - endothelial cell KW - angiogenesis KW - Transformation KW - Mimicry KW - Human herpesvirus 8 KW - double prime G protein-coupled receptors KW - Secretions KW - Paracrine signalling KW - Kaposi's sarcoma-associated herpesvirus KW - Infection KW - Neoplasia KW - NF- Kappa B protein KW - Gene expression KW - Endothelial cells KW - Malignancy KW - Oncogenes KW - Kaposi's sarcoma KW - Open reading frames KW - Signal transduction KW - W 30925:Genetic Engineering KW - B 26650:Viral Oncogenes KW - G 07730:Development & Cell Cycle KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19706250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=An+NF-%5Bkappa%5DB+gene+expression+signature+contributes+to+Kaposi%27s+sarcoma+virus+vGPCR-induced+direct+and+paracrine+neoplasia&rft.au=Martin%2C+D%3BGalisteo%2C+R%3BJi%2C+Y%3BMontaner%2C+S%3BGutkind%2C+J+S&rft.aulast=Martin&rft.aufirst=D&rft.date=2008-03-01&rft.volume=12&rft.issue=13&rft.spage=1844&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1210817 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transformation; Mimicry; double prime G protein-coupled receptors; Paracrine signalling; Secretions; Infection; Neoplasia; NF- Kappa B protein; Endothelial cells; Gene expression; Malignancy; Oncogenes; Kaposi's sarcoma; Open reading frames; Signal transduction; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus DO - http://dx.doi.org/10.1038/sj.onc.1210817 ER - TY - JOUR T1 - Ischemia-elicited oxidative modulation of Ca2+/calmodulin-dependent protein kinase II. AN - 70330403; 18174165 AB - Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays a critical role in neuronal signal transduction and synaptic plasticity. Here, we showed that this kinase was very susceptible to oxidative modulation. Treatment of mouse brain synaptosomes with H2O2, diamide, and sodium nitroprusside caused aggregation of CaMKII through formation of disulfide and non-disulfide linkages, and partial inhibition of the kinase activity. These CaMKII aggregates were found to associate with the post synaptic density. However, treatment of purified CaMKII with these oxidants did not replicate those effects observed in the synaptosomes. Using two previously identified potential mediators of oxidants in the brain, glutathione disulfide S-monoxide (GS-DSMO) and glutathione disulfide S-dioxide (GS-DSDO), we showed that they oxidized and inhibited CaMKII in a manner partly related to those of the oxidant-treated synaptosomes as well as the ischemia-elicited oxidative stress in the acutely prepared hippocampal slices. Interestingly, the autophosphorylated and activated CaMKII was relatively refractory to GS-DSMO- and GS-DSDO-mediated aggregation. Short term ischemia (10 min) caused a depression of basal synaptic response of the hippocampal slices, and re-oxygenation (after 10 min) reversed the depression. However, oxidation of CaMKII remained at above the pre-ischemic level throughout the treatment. Oxidation of CaMKII also prevented full recovery of CaMKII autophosphorylation after re-oxygenation. Subsequently, the high frequency stimulation-mediated synaptic potentiation in the hippocampal CA1 region was significantly reduced compared with the control without ischemia. Thus, ischemia-evoked oxidation of CaMKII, probably via the action of glutathione disulfide S-oxides or their analogues, may be involved in the suppression of synaptic plasticity. JF - The Journal of biological chemistry AU - Shetty, Pavan K AU - Huang, Freesia L AU - Huang, Kuo-Ping AD - Developmental Neurobiology Program, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/02/29/ PY - 2008 DA - 2008 Feb 29 SP - 5389 EP - 5401 VL - 283 IS - 9 SN - 0021-9258, 0021-9258 KW - Disulfides KW - 0 KW - Oxidants KW - Protein Kinase Inhibitors KW - glutathione disulfide S-oxide KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2 KW - EC 2.7.11.17 KW - Glutathione Disulfide KW - ULW86O013H KW - Index Medicus KW - Protein Processing, Post-Translational -- drug effects KW - Animals KW - Phosphorylation KW - Oxidation-Reduction -- drug effects KW - Signal Transduction -- drug effects KW - Neuronal Plasticity -- drug effects KW - Mice KW - Disulfides -- metabolism KW - Protein Kinase Inhibitors -- metabolism KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2 -- metabolism KW - Brain Ischemia -- enzymology KW - Oxidants -- pharmacology KW - Glutathione Disulfide -- metabolism KW - Synaptosomes -- pathology KW - Glutathione Disulfide -- analogs & derivatives KW - Brain Ischemia -- pathology KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2 -- antagonists & inhibitors KW - Synaptosomes -- enzymology KW - Hippocampus -- enzymology KW - Oxidants -- metabolism KW - Hippocampus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70330403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Ischemia-elicited+oxidative+modulation+of+Ca2%2B%2Fcalmodulin-dependent+protein+kinase+II.&rft.au=Shetty%2C+Pavan+K%3BHuang%2C+Freesia+L%3BHuang%2C+Kuo-Ping&rft.aulast=Shetty&rft.aufirst=Pavan&rft.date=2008-02-29&rft.volume=283&rft.issue=9&rft.spage=5389&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M708479200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-15 N1 - Date created - 2008-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M708479200 ER - TY - JOUR T1 - Covalent modification of stathmin by CCNU determined by FTMS analysis of modified proteins and tryptic peptides. AN - 70209788; 18162179 AB - Chemical modification of proteins is often carried out to generate protein-small molecule conjugates for various applications. The high resolution and mass accuracy of a Fourier transform mass spectrometer is particularly useful for assessing the extent or sites of covalent modifications. As protein-small molecule reactions often produce products with variable numbers of the compound incorporated at different sites, a direct mass analysis of the reaction products at times yields mass spectra hard to interpret. Chromatographic separation at protein level could reduce the complexity of a sample, thus allowing more accurate mass spectrometric analysis. In this report, we demonstrate the utility of reversed-phase protein chromatography and FT-ICR mass spectrometry in analyzing CCNU (lomustine, 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-urea, MW: 233.7Da) modification of stathmin. With this combined approach, we determined the stoichiometry as well as sites of CCNU incorporation into the protein, demonstrating differential reactivity of several lysyl residues to CCNU alkylation. JF - Biochemical and biophysical research communications AU - Wu, Wells W AU - Wang, Guanghui AU - Liang, Xing-Jie AU - Park, John K AU - Shen, Rong-Fong AD - Proteomics Core Facility, National Heart, Lung, and Blood Institute, NIH, Building 10, Room 8C103C, 10 Center Drive, Bethesda, MD 20892-1597, USA. Y1 - 2008/02/29/ PY - 2008 DA - 2008 Feb 29 SP - 7 EP - 13 VL - 367 IS - 1 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Peptides KW - Stathmin KW - Lomustine KW - 7BRF0Z81KG KW - Trypsin KW - EC 3.4.21.4 KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Base Sequence KW - Lysine -- chemistry KW - Humans KW - Chromatography, High Pressure Liquid -- methods KW - Lysine -- metabolism KW - Binding Sites KW - Alkylation KW - Trypsin -- chemistry KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Lomustine -- pharmacology KW - Stathmin -- metabolism KW - Peptides -- analysis KW - Trypsin -- metabolism KW - Trypsin -- analysis KW - Stathmin -- chemistry KW - Peptides -- metabolism KW - Peptides -- chemistry KW - Mass Spectrometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70209788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Covalent+modification+of+stathmin+by+CCNU+determined+by+FTMS+analysis+of+modified+proteins+and+tryptic+peptides.&rft.au=Wu%2C+Wells+W%3BWang%2C+Guanghui%3BLiang%2C+Xing-Jie%3BPark%2C+John+K%3BShen%2C+Rong-Fong&rft.aulast=Wu&rft.aufirst=Wells&rft.date=2008-02-29&rft.volume=367&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=1090-2104&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-07 N1 - Date created - 2008-01-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12008-13 [11035807] J Proteome Res. 2007 Jul;6(7):2447-59 [17506541] J Mass Spectrom. 2002 Jul;37(7):663-75 [12124999] J Am Chem Soc. 2002 Sep 4;124(35):10256-7 [12197709] Org Biomol Chem. 2003 Nov 7;1(21):3645-6 [14649894] Cell Struct Funct. 1999 Oct;24(5):345-57 [15216892] J Biochem Biophys Methods. 2004 Sep 30;60(3):265-80 [15345295] Cancer Res. 1972 Jan;32(1):22-7 [5007685] Anal Chem. 1997 Jun 1;69(11):2159-64 [9183179] J Mass Spectrom. 1998 Mar;33(3):264-73 [9538525] J Proteome Res. 2006 May;5(5):1214-23 [16674111] J Sep Sci. 2006 Aug;29(12):1784-821 [16970185] J Natl Cancer Inst. 2007 Apr 18;99(8):639-52 [17440165] Nat Methods. 2007 Jun;4(6):487-9 [17529979] Anal Chem. 2001 Feb 1;73(3):571-81 [11217765] N1 - Last updated - 2017-01-19 ER - TY - CPAPER T1 - Genome-Wide Association Studies in Breast and Prostate Cancer: Cancer Genetic Markers of Susceptibility (CGEMS). T2 - 2008 Keystone Symposia on Complex Traits: Biologic and Therapeutic Insights (C4) AN - 40781132; 4787927 JF - 2008 Keystone Symposia on Complex Traits: Biologic and Therapeutic Insights (C4) AU - Chanock, Stephen Y1 - 2008/02/29/ PY - 2008 DA - 2008 Feb 29 KW - Prostate cancer KW - Genetic markers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Complex+Traits%3A+Biologic+and+Therapeutic+Insights+%28C4%29&rft.atitle=Genome-Wide+Association+Studies+in+Breast+and+Prostate+Cancer%3A+Cancer+Genetic+Markers+of+Susceptibility+%28CGEMS%29.&rft.au=Chanock%2C+Stephen&rft.aulast=Chanock&rft.aufirst=Stephen&rft.date=2008-02-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Complex+Traits%3A+Biologic+and+Therapeutic+Insights+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Collaboration and Data Sharing in the Genetic Association Information Network T2 - 2008 Keystone Symposia on Complex Traits: Biologic and Therapeutic Insights (C4) AN - 40777970; 4787931 JF - 2008 Keystone Symposia on Complex Traits: Biologic and Therapeutic Insights (C4) AU - Manolio, Teri Y1 - 2008/02/29/ PY - 2008 DA - 2008 Feb 29 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Complex+Traits%3A+Biologic+and+Therapeutic+Insights+%28C4%29&rft.atitle=Collaboration+and+Data+Sharing+in+the+Genetic+Association+Information+Network&rft.au=Manolio%2C+Teri&rft.aulast=Manolio&rft.aufirst=Teri&rft.date=2008-02-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Complex+Traits%3A+Biologic+and+Therapeutic+Insights+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following 2-year inhalation exposure. AN - 70357352; 18178301 AB - Methyl isobutyl ketone (MIBK) is primarily used as a denaturant for rubbing alcohol, as a solvent and in the manufacture of methyl amyl alcohol. Inhalation of vapors is the most likely route of exposure in the work place. In order to evaluate the potential of MIBK to induce toxic and carcinogenic effects following chronic exposure, groups of 50 male and 50 female F344/N rats and B6C3F1 mice were exposed to MIBK at concentrations of 0, 450, 900, or 1800ppm by inhalation, 6h/day, 5 days per week for 2 years. Survival was decreased in male rats at 1800ppm. Body weight gains were decreased in male rats at 900 and 1800ppm and in female mice at 1800ppm. The primary targets of MIBK toxicity and carcinogenicity were the kidney in rats and the liver in mice. In male rats, there was increased mineralization of the renal papilla at all exposure concentrations. The incidence of chronic progressive nephropathy (CPN) was increased at 1800ppm and the severity was increased in all exposed groups. There were also increases in renal tubule hyperplasia at all exposure concentrations, and in adenoma and adenoma or carcinoma (combined) at 1800ppm; these lesions are thought to represent a continuum in the progression of proliferative lesions in renal tubule epithelium. These increases may have resulted from the increased severity of CPN, either through alpha2micro-globulin-dependent or -independent mechanisms. An increase in mononuclear cell leukemia at 1800ppm was an uncertain finding. Adrenal medulla hyperplasia was increased at 1800ppm, and there was a positive trend for increases in benign or malignant pheochromocytomas (combined). In female rats, there were increases in the incidence of CPN in all exposure concentrations and in the severity at 1800ppm, indicating that CPN was increased by mechanisms in addition to those related to alpha2micro-globulin. There were renal mesenchymal tumors, which have not been observed in historical control animals, in two female rats at 1800ppm. The relationship of these tumors to exposure to MIBK was uncertain. Hepatocellular adenomas, and adenoma or carcinoma (combined) were increased in male and female mice exposed to 1800ppm. There were also treatment-related increases in multiple adenomas in both sexes. JF - Toxicology AU - Stout, Matthew D AU - Herbert, Ronald A AU - Kissling, Grace E AU - Suarez, Fernando AU - Roycroft, Joseph H AU - Chhabra, Rajendra S AU - Bucher, John R AD - Toxicology Operations Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. stoutm@niehs.nih.gov Y1 - 2008/02/28/ PY - 2008 DA - 2008 Feb 28 SP - 209 EP - 219 VL - 244 IS - 2-3 SN - 0300-483X, 0300-483X KW - Carcinogens KW - 0 KW - Methyl n-Butyl Ketone KW - 6QDY60NH6N KW - methyl isobutyl ketone KW - U5T7B88CNP KW - Index Medicus KW - Weight Gain -- drug effects KW - Animals KW - Kidney Neoplasms -- pathology KW - Dose-Response Relationship, Drug KW - Kidney Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Liver Neoplasms, Experimental -- chemically induced KW - Mice KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Carcinoma -- pathology KW - Liver Neoplasms, Experimental -- pathology KW - Inhalation Exposure KW - Neoplasms -- chemically induced KW - Adenoma -- chemically induced KW - Adenoma -- pathology KW - Male KW - Female KW - Survival Analysis KW - Carcinoma -- chemically induced KW - Methyl n-Butyl Ketone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70357352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Toxicity+and+carcinogenicity+of+methyl+isobutyl+ketone+in+F344N+rats+and+B6C3F1+mice+following+2-year+inhalation+exposure.&rft.au=Stout%2C+Matthew+D%3BHerbert%2C+Ronald+A%3BKissling%2C+Grace+E%3BSuarez%2C+Fernando%3BRoycroft%2C+Joseph+H%3BChhabra%2C+Rajendra+S%3BBucher%2C+John+R&rft.aulast=Stout&rft.aufirst=Matthew&rft.date=2008-02-28&rft.volume=244&rft.issue=2-3&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.11.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-09 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mutat Res. 1988 Oct;206(2):149-61 [3050497] Biometrics. 1988 Jun;44(2):417-31 [3390507] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Endocrinology. 1989 Sep;125(3):1385-8 [2474439] Annu Rev Pharmacol Toxicol. 1990;30:349-67 [1693054] Can J Physiol Pharmacol. 1990 Aug;68(8):1055-61 [2390735] Biochem Pharmacol. 1991 Mar 15-Apr 1;41(6-7):877-83 [2009082] Toxicol Appl Pharmacol. 1992 Feb;112(2):214-21 [1371614] Environ Mol Mutagen. 1992;19 Suppl 21:2-141 [1541260] Regul Toxicol Pharmacol. 1992 Oct;16(2):111-25 [1279759] Toxicol Lett. 1994 Feb 15;70(3):263-7 [8284793] Toxicol Lett. 1995 Jan;75(1-3):51-8 [7863537] J Toxicol Environ Health. 1995 Aug;45(4):465-80 [7643433] J Toxicol Environ Health. 1995 Nov;46(3):317-28 [7473860] Toxicol Pathol. 1997 Mar-Apr;25(2):132-43 [9125771] Toxicol Pathol. 1998 Jan-Feb;26(1):104-12 [9502392] Natl Toxicol Program Tech Rep Ser. 2007 Feb;(538):1-236 [17557116] Toxicol Pathol. 2007 Jun;35(4):533-40 [17562486] Natl Toxicol Program Tech Rep Ser. 2002 May;(504):1-357 [12087420] Toxicol Sci. 2002 Sep;69(1):30-41 [12215658] Toxicol Pathol. 2002 Nov-Dec;30(6):681-6 [12512869] Int J Toxicol. 2004 Mar-Apr;23(2):127-43 [15204733] Crit Rev Toxicol. 2004 May-Jun;34(3):211-99 [15239388] Toxicol Pathol. 2004 Jul-Aug;32(4):393-401 [15307212] Biometrics. 1971 Mar;27(1):103-17 [5547548] Biometrics. 1972 Jun;28(2):519-31 [5037867] CRC Crit Rev Toxicol. 1974 Sep;3(1):97-158 [4373214] Toxicol Appl Pharmacol. 1976 Jun;36(3):511-22 [941151] Toxicol Appl Pharmacol. 1985 Sep 15;80(2):228-34 [4024113] Toxicol Appl Pharmacol. 1985 Oct;81(1):1-16 [4049411] Mol Cell Biol. 1986 Oct;6(10):3563-7 [2432391] Fundam Appl Toxicol. 1987 Oct;9(3):380-8 [3691997] Toxicol Appl Pharmacol. 1988 Mar 15;92(3):419-27 [3353988] Toxicol Appl Pharmacol. 1989 Jan;97(1):35-46 [2464861] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2007.11.014 ER - TY - CPAPER T1 - Interferon-beta for Ulcerative Colitis: Long-standing Clinical Repsonses and Remissions in Active Disease T2 - 3rd Congress of the European Crohn's and Colitis Organisation (Inflammatory Bowel Diseases 2008) AN - 40826818; 4808792 JF - 3rd Congress of the European Crohn's and Colitis Organisation (Inflammatory Bowel Diseases 2008) AU - Mannon, P AU - Fuss, I AU - Groden, C AU - Friend, J AU - Yao, M AU - Strober, W Y1 - 2008/02/28/ PY - 2008 DA - 2008 Feb 28 KW - Ulcerative colitis KW - Remission KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40826818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Congress+of+the+European+Crohn%27s+and+Colitis+Organisation+%28Inflammatory+Bowel+Diseases+2008%29&rft.atitle=Interferon-beta+for+Ulcerative+Colitis%3A+Long-standing+Clinical+Repsonses+and+Remissions+in+Active+Disease&rft.au=Mannon%2C+P%3BFuss%2C+I%3BGroden%2C+C%3BFriend%2C+J%3BYao%2C+M%3BStrober%2C+W&rft.aulast=Mannon&rft.aufirst=P&rft.date=2008-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Congress+of+the+European+Crohn%27s+and+Colitis+Organisation+%28Inflammatory+Bowel+Diseases+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://ecco08.ecco-ibd.eu/programme/overview.php?navId=108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Development of an Advanced Care Planning Tool for Adolescents and Young Adults With High Risk Cancer or HIV Disease T2 - 5th Annual Conference of American Psychosocial Oncology Society (APOS 2008) AN - 40793049; 4791012 JF - 5th Annual Conference of American Psychosocial Oncology Society (APOS 2008) AU - Brennan, T AU - Wiener, L AU - Ballard, E AU - Pao, M AU - Battles, H Y1 - 2008/02/28/ PY - 2008 DA - 2008 Feb 28 KW - Cancer KW - Human immunodeficiency virus KW - Adolescents KW - Young adults KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40793049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Conference+of+American+Psychosocial+Oncology+Society+%28APOS+2008%29&rft.atitle=The+Development+of+an+Advanced+Care+Planning+Tool+for+Adolescents+and+Young+Adults+With+High+Risk+Cancer+or+HIV+Disease&rft.au=Brennan%2C+T%3BWiener%2C+L%3BBallard%2C+E%3BPao%2C+M%3BBattles%2C+H&rft.aulast=Brennan&rft.aufirst=T&rft.date=2008-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Conference+of+American+Psychosocial+Oncology+Society+%28APOS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://apos.conference-services.net/programme.asp?conferenceID=1137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. AN - 70340660; 18305243 AB - Auditory fear conditioning, a model for fear learning, is thought to be mediated by synaptic changes in the cortical and thalamic inputs to the lateral amygdala (LA); however, the specific roles of both pathways are still debated. Here, we report that a CaMKII-alpha-Cre-mediated knock-out (KO) of the rap1a and rap1b genes impaired synaptic plasticity and increased basal synaptic transmission in the cortical but not thalamic input to the LA via presynaptic changes: increases in glutamate release probability and the number of glutamate quanta released by a single action potential. Moreover, KO mice with alterations in the cortico-LA pathway had impaired fear learning, which could be rescued by training with a more aversive unconditional stimulus. These results suggest that Rap1-mediated suppression of synaptic transmission enables plasticity in the cortico-amygdala pathway, which is required for fear learning with a moderately aversive unconditional stimulus. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Pan, Bing-Xing AU - Vautier, Francois AU - Ito, Wataru AU - Bolshakov, Vadim Y AU - Morozov, Alexei AD - Unit on Behavioral Genetics, Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/02/27/ PY - 2008 DA - 2008 Feb 27 SP - 2089 EP - 2098 VL - 28 IS - 9 KW - Excitatory Amino Acid Antagonists KW - 0 KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Calcium-Calmodulin-Dependent Protein Kinase Kinase KW - EC 2.7.11.17 KW - Rap1b protein, mouse KW - EC 3.6.1.- KW - rap GTP-Binding Proteins KW - EC 3.6.5.2 KW - rap1 GTP-Binding Proteins KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Electric Stimulation -- methods KW - Maze Learning -- physiology KW - Mice KW - Dose-Response Relationship, Radiation KW - Behavior, Animal KW - Mice, Knockout KW - Conditioning (Psychology) -- drug effects KW - Dizocilpine Maleate -- pharmacology KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Synaptic Transmission -- genetics KW - Calcium-Calmodulin-Dependent Protein Kinase Kinase -- metabolism KW - Conditioning (Psychology) -- physiology KW - In Vitro Techniques KW - rap GTP-Binding Proteins -- deficiency KW - Cerebral Cortex -- physiology KW - Amygdala -- physiology KW - Fear -- physiology KW - rap1 GTP-Binding Proteins -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70340660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Enhanced+cortico-amygdala+efficacy+and+suppressed+fear+in+absence+of+Rap1.&rft.au=Pan%2C+Bing-Xing%3BVautier%2C+Francois%3BIto%2C+Wataru%3BBolshakov%2C+Vadim+Y%3BMorozov%2C+Alexei&rft.aulast=Pan&rft.aufirst=Bing-Xing&rft.date=2008-02-27&rft.volume=28&rft.issue=9&rft.spage=2089&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.5156-07.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.5156-07.2008 ER - TY - CPAPER T1 - Featured Speaker: Electron Tomography of Immunodeficiency Viruses and Structural Mechanisms of Cellular Entry T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40838566; 4809242 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Subramaniam, Sriram Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Viruses KW - Immunodeficiency KW - Tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Featured+Speaker%3A+Electron+Tomography+of+Immunodeficiency+Viruses+and+Structural+Mechanisms+of+Cellular+Entry&rft.au=Subramaniam%2C+Sriram&rft.aulast=Subramaniam&rft.aufirst=Sriram&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influenza Virus: A Continuously Emerging Infectious Disease T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40838531; 4809230 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Taubenberger, Jeffery K Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Influenza KW - Infectious diseases KW - Influenza A virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40838531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Influenza+Virus%3A+A+Continuously+Emerging+Infectious+Disease&rft.au=Taubenberger%2C+Jeffery+K&rft.aulast=Taubenberger&rft.aufirst=Jeffery&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Protection Against Pulmonary Infection with F. tularensis SCHU4 T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40835235; 4809202 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Chase, J AU - OlivaresZavaleta, N AU - Fairman, J AU - Bosio, C M Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Infection KW - Lung KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Rapid+Protection+Against+Pulmonary+Infection+with+F.+tularensis+SCHU4&rft.au=Chase%2C+J%3BOlivaresZavaleta%2C+N%3BFairman%2C+J%3BBosio%2C+C+M&rft.aulast=Chase&rft.aufirst=J&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Featured Presentation: The Pandemic Threat of Avian Influenza Viruses T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40829752; 4809120 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Subbarao, Kanta Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Influenza KW - Viruses KW - Fowl plague KW - Pandemics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40829752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Featured+Presentation%3A+The+Pandemic+Threat+of+Avian+Influenza+Viruses&rft.au=Subbarao%2C+Kanta&rft.aulast=Subbarao&rft.aufirst=Kanta&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coxiella burnetti T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40828921; 4809002 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Heinzen, Robert A Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40828921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Coxiella+burnetti&rft.au=Heinzen%2C+Robert+A&rft.aulast=Heinzen&rft.aufirst=Robert&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Barriers to Inter Species Transmission of Prion Diseases T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40828106; 4809121 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Priola, Suzette Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Prion protein KW - Disease transmission KW - Barriers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40828106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Barriers+to+Inter+Species+Transmission+of+Prion+Diseases&rft.au=Priola%2C+Suzette&rft.aulast=Priola&rft.aufirst=Suzette&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Francisella tularensis T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40826317; 4809001 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Celli, Jean Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Macrophages KW - Francisella tularensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40826317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Francisella+tularensis&rft.au=Celli%2C+Jean&rft.aulast=Celli&rft.aufirst=Jean&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaptation to Growth in Tick Cells Alters Pathogenicity of a Tick borne Flavivirus. T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40825681; 4809093 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Mitzel, D AU - Masnick, M AU - Wolfinbarger, J AU - Best, S AU - Bloom, M E Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Adaptations KW - Pathogenicity KW - Growth KW - Ixodidae KW - Flavivirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40825681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Adaptation+to+Growth+in+Tick+Cells+Alters+Pathogenicity+of+a+Tick+borne+Flavivirus.&rft.au=Mitzel%2C+D%3BMasnick%2C+M%3BWolfinbarger%2C+J%3BBest%2C+S%3BBloom%2C+M+E&rft.aulast=Mitzel&rft.aufirst=D&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA Electroporation T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40824393; 4809115 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Pavlakis, George N Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Electroporation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40824393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=DNA+Electroporation&rft.au=Pavlakis%2C+George+N&rft.aulast=Pavlakis&rft.aufirst=George&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VRC Clinical Trials T2 - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AN - 40824362; 4809114 JF - 6th Annual ASM Biodefense and Emerging Diseases Research Meeting AU - Martin, Julie E Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40824362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=VRC+Clinical+Trials&rft.au=Martin%2C+Julie+E&rft.aulast=Martin&rft.aufirst=Julie&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/documents/2008Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ligand Recognition by NK Receptors T2 - 2008 Keystone Symposia on NK and NKT Cell Biology (X5) AN - 40781221; 4787942 JF - 2008 Keystone Symposia on NK and NKT Cell Biology (X5) AU - Sun, Peter D Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+NK+and+NKT+Cell+Biology+%28X5%29&rft.atitle=Ligand+Recognition+by+NK+Receptors&rft.au=Sun%2C+Peter+D&rft.aulast=Sun&rft.aufirst=Peter&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+NK+and+NKT+Cell+Biology+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=93 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Signaling Complex of TLR3 T2 - 2008 Keystone Symposia on Innate Immunity: Signaling Mechanisms (X6) AN - 40781052; 4787887 JF - 2008 Keystone Symposia on Innate Immunity: Signaling Mechanisms (X6) AU - Leonard, Joshua N Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - TLR3 protein KW - Signal transduction KW - Toll-like receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Innate+Immunity%3A+Signaling+Mechanisms+%28X6%29&rft.atitle=The+Signaling+Complex+of+TLR3&rft.au=Leonard%2C+Joshua+N&rft.aulast=Leonard&rft.aufirst=Joshua&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Innate+Immunity%3A+Signaling+Mechanisms+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=93 6&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Molecular Basis of NOD2 Susceptibility Mutations in Crohns Disease T2 - 2008 Keystone Symposia on Innate Immunity: Signaling Mechanisms (X6) AN - 40781012; 4787882 JF - 2008 Keystone Symposia on Innate Immunity: Signaling Mechanisms (X6) AU - Strober, Warren Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Mutation KW - NOD2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Innate+Immunity%3A+Signaling+Mechanisms+%28X6%29&rft.atitle=The+Molecular+Basis+of+NOD2+Susceptibility+Mutations+in+Crohns+Disease&rft.au=Strober%2C+Warren&rft.aulast=Strober&rft.aufirst=Warren&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Innate+Immunity%3A+Signaling+Mechanisms+%28X6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=93 6&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Smith-Lemli-Opitz Syndrome: Mouse Models, Pathophysiology, and Treatment T2 - 2008 Keystone Symposia on Towards Identifying the Pathophysiology of Autistic Syndromes (C2) AN - 40778233; 4787809 JF - 2008 Keystone Symposia on Towards Identifying the Pathophysiology of Autistic Syndromes (C2) AU - Porter, Forbes D Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Animal models KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40778233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Towards+Identifying+the+Pathophysiology+of+Autistic+Syndromes+%28C2%29&rft.atitle=Smith-Lemli-Opitz+Syndrome%3A+Mouse+Models%2C+Pathophysiology%2C+and+Treatment&rft.au=Porter%2C+Forbes+D&rft.aulast=Porter&rft.aufirst=Forbes&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Towards+Identifying+the+Pathophysiology+of+Autistic+Syndromes+%28C2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=92 8&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phenotypic Changes in IFN-gamma 3UTR ARE Knock out Mice T2 - 2008 Keystone Symposia on NK and NKT Cell Biology (X5) AN - 40774008; 4787966 JF - 2008 Keystone Symposia on NK and NKT Cell Biology (X5) AU - Hodge, Deborah L Y1 - 2008/02/24/ PY - 2008 DA - 2008 Feb 24 KW - Mice KW - G-Interferon KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40774008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+NK+and+NKT+Cell+Biology+%28X5%29&rft.atitle=Phenotypic+Changes+in+IFN-gamma+3UTR+ARE+Knock+out+Mice&rft.au=Hodge%2C+Deborah+L&rft.aulast=Hodge&rft.aufirst=Deborah&rft.date=2008-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+NK+and+NKT+Cell+Biology+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=93 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structural Biophysics of the NusB:NusE Antitermination Complex AN - 19797191; 8244698 AB - In prokaryotic transcription regulation, several host factors form a complex with RNA polymerase and the nascent mRNA. As part of a process known as antitermination, two of these host factors, NusB and NusE, bind to form a heterodimer, which interacts with a specific boxA site on the RNA. The NusB/NusE/boxA RNA ternary complex interacts with the RNA polymerase transcription complex, stabilizing it and allowing transcription past premature termination points. The NusB protein also binds boxA RNA individually and retains all specificity for boxA. However, NusE increases the affinity of RNA to NusB in the ternary complex, which contributes to efficient antitermination. To understand the molecular mechanism of the process, we have determined the structure of NusB from the thermophilic bacterium Aquifex aeolicus and studied the interaction of NusB and NusE. We characterize this binding interaction using NMR, isothermal titration calorimetry, gel filtration, and analytical ultracentrifugation. The binding site of NusE on NusB was determined using NMR chemical shift perturbation studies. We have also determined the NusE binding site in the ternary Escherichia coli NusB/NusE/boxA RNA complex and show that it is very similar to that in the NusB/NusE complex. There is one loop of residues (from 113 to 118 in NusB) affected by NusE binding in the ternary complex but not in the binary complex. This difference may be correlated to an increase in binding affinity of RNA for the NusB/NusE complex. determination JF - Journal of Molecular Biology AU - Das, R AU - Loss, S AU - Li, J AU - Waugh, D S AU - Tarasov, S AU - Wingfield, P T AU - Byrd, R A AU - Altieri, A S AD - National Cancer Institute, Frederick, MD 21702, USA, rabyrd@ncifcrf.gov Y1 - 2008/02/22/ PY - 2008 DA - 2008 Feb 22 SP - 705 EP - 720 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 376 IS - 3 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Molecular modelling KW - Transcription KW - Ultracentrifugation KW - Biophysics KW - DNA-directed RNA polymerase KW - Filtration KW - Aquifex aeolicus KW - Titration KW - Escherichia coli KW - Calorimetry KW - N.M.R. KW - NusB protein KW - N 14830:RNA KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19797191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Structural+Biophysics+of+the+NusB%3ANusE+Antitermination+Complex&rft.au=Das%2C+R%3BLoss%2C+S%3BLi%2C+J%3BWaugh%2C+D+S%3BTarasov%2C+S%3BWingfield%2C+P+T%3BByrd%2C+R+A%3BAltieri%2C+A+S&rft.aulast=Das&rft.aufirst=R&rft.date=2008-02-22&rft.volume=376&rft.issue=3&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2007.11.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Filtration; DNA-directed RNA polymerase; Titration; Calorimetry; Transcription; N.M.R.; NusB protein; Ultracentrifugation; Biophysics; Aquifex aeolicus; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2007.11.022 ER - TY - JOUR T1 - Household vacuum cleaners vs. the high-volume surface sampler for collection of carpet dust samples in epidemiologic studies of children. AN - 70379604; 18291036 AB - Levels of pesticides and other compounds in carpet dust can be useful indicators of exposure in epidemiologic studies, particularly for young children who are in frequent contact with carpets. The high-volume surface sampler (HVS3) is often used to collect dust samples in the room in which the child had spent the most time. This method can be expensive and cumbersome, and it has been suggested that an easier method would be to remove dust that had already been collected with the household vacuum cleaner. However, the household vacuum integrates exposures over multiple rooms, some of which are not relevant to the child's exposure, and differences in vacuuming equipment and practices could affect the chemical concentration data. Here, we compare levels of pesticides and other compounds in dust from household vacuums to that collected using the HVS3. Both methods were used in 45 homes in California. HVS3 samples were collected in one room, while the household vacuum had typically been used throughout the home. The samples were analyzed for 64 organic compounds, including pesticides, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls (PCBs), using GC/MS in multiple ion monitoring mode; and for nine metals using conventional microwave-assisted acid digestion combined with ICP/MS. The methods agreed in detecting the presence of the compounds 77% to 100% of the time (median 95%). For compounds with less than 100% agreement, neither method was consistently more sensitive than the other. Median concentrations were similar for most analytes, and Spearman correlation coefficients were 0.60 or higher except for allethrin (0.15) and malathion (0.24), which were detected infrequently, and benzo(k)fluoranthene (0.55), benzo(a)pyrene (0.55), PCB 105 (0.54), PCB 118 (0.54), and PCB 138 (0.58). Assuming that the HVS3 method is the "gold standard," the extent to which the household vacuum cleaner method yields relative risk estimates closer to unity by increasing random measurement error varies by compound and depends on the method used to calculate relative risk. The household vacuum cleaner method appears to be a reasonable alternative to the HVS3 for detecting, ranking, and quantifying the concentrations of pesticides and other compounds in carpet dust. JF - Environmental health : a global access science source AU - Colt, Joanne S AU - Gunier, Robert B AU - Metayer, Catherine AU - Nishioka, Marcia G AU - Bell, Erin M AU - Reynolds, Peggy AU - Buffler, Patricia A AU - Ward, Mary H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd. MSC 7240, Bethesda, MD, 20892-7240, USA. coltj@mail.nih.gov Y1 - 2008/02/21/ PY - 2008 DA - 2008 Feb 21 SP - 6 VL - 7 KW - Dust KW - 0 KW - Pesticide Residues KW - Index Medicus KW - Housekeeping KW - California KW - Epidemiologic Studies KW - Humans KW - Environmental Exposure -- analysis KW - Pesticide Residues -- isolation & purification KW - Floors and Floorcoverings KW - Dust -- analysis KW - Specimen Handling -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70379604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+%3A+a+global+access+science+source&rft.atitle=Household+vacuum+cleaners+vs.+the+high-volume+surface+sampler+for+collection+of+carpet+dust+samples+in+epidemiologic+studies+of+children.&rft.au=Colt%2C+Joanne+S%3BGunier%2C+Robert+B%3BMetayer%2C+Catherine%3BNishioka%2C+Marcia+G%3BBell%2C+Erin+M%3BReynolds%2C+Peggy%3BBuffler%2C+Patricia+A%3BWard%2C+Mary+H&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2008-02-21&rft.volume=7&rft.issue=&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Environmental+health+%3A+a+global+access+science+source&rft.issn=1476-069X&rft_id=info:doi/10.1186%2F1476-069X-7-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2008-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Air Waste Manag Assoc. 2001 Mar;51(3):339-51 [11266098] Breast Cancer Res Treat. 2002 Jun;74(3):235-54 [12206514] Int J Epidemiol. 1989 Sep;18(3):705-12 [2807678] Sci Total Environ. 1990 Jan;90:13-29 [2305239] J Expo Anal Environ Epidemiol. 1991 Apr;1(2):143-55 [1844216] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] J Expo Sci Environ Epidemiol. 2007 Jul;17(4):331-49 [16736054] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] Environ Health Perspect. 1998 Nov;106(11):721-4 [9799187] Environ Health Perspect. 1999 Sep;107(9):721-6 [10464072] Epidemiology. 2005 Jul;16(4):516-25 [15951670] Am J Epidemiol. 2006 Jun 15;163(12):1091-100 [16597704] Environ Res. 1995 Feb;68(2):114-23 [7601072] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1476-069X-7-6 ER - TY - JOUR T1 - Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. AN - 70326535; 18297132 AB - Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the precise molecular alterations induced by smoking in lung that develop into cancer and impact survival have remained obscure. We performed gene expression analysis using HG-U133A Affymetrix chips on 135 fresh frozen tissue samples of adenocarcinoma and paired noninvolved lung tissue from current, former and never smokers, with biochemically validated smoking information. ANOVA analysis adjusted for potential confounders, multiple testing procedure, Gene Set Enrichment Analysis, and GO-functional classification were conducted for gene selection. Results were confirmed in independent adenocarcinoma and non-tumor tissues from two studies. We identified a gene expression signature characteristic of smoking that includes cell cycle genes, particularly those involved in the mitotic spindle formation (e.g., NEK2, TTK, PRC1). Expression of these genes strongly differentiated both smokers from non-smokers in lung tumors and early stage tumor tissue from non-tumor tissue (p1.5, for each comparison), consistent with an important role for this pathway in lung carcinogenesis induced by smoking. These changes persisted many years after smoking cessation. NEK2 (p<0.001) and TTK (p = 0.002) expression in the noninvolved lung tissue was also associated with a 3-fold increased risk of mortality from lung adenocarcinoma in smokers. Our work provides insight into the smoking-related mechanisms of lung neoplasia, and shows that the very mitotic genes known to be involved in cancer development are induced by smoking and affect survival. These genes are candidate targets for chemoprevention and treatment of lung cancer in smokers. JF - PloS one AU - Landi, Maria Teresa AU - Dracheva, Tatiana AU - Rotunno, Melissa AU - Figueroa, Jonine D AU - Liu, Huaitian AU - Dasgupta, Abhijit AU - Mann, Felecia E AU - Fukuoka, Junya AU - Hames, Megan AU - Bergen, Andrew W AU - Murphy, Sharon E AU - Yang, Ping AU - Pesatori, Angela C AU - Consonni, Dario AU - Bertazzi, Pier Alberto AU - Wacholder, Sholom AU - Shih, Joanna H AU - Caporaso, Neil E AU - Jen, Jin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 SP - 1 VL - 3 IS - 2 KW - Index Medicus KW - Humans KW - Gene Expression Regulation KW - Biopsy KW - Cell Transformation, Neoplastic KW - Gene Expression Profiling KW - Lung Neoplasms -- etiology KW - Genes, cdc KW - Adenocarcinoma -- etiology KW - Smoking -- adverse effects KW - Smoking -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70326535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Gene+expression+signature+of+cigarette+smoking+and+its+role+in+lung+adenocarcinoma+development+and+survival.&rft.au=Landi%2C+Maria+Teresa%3BDracheva%2C+Tatiana%3BRotunno%2C+Melissa%3BFigueroa%2C+Jonine+D%3BLiu%2C+Huaitian%3BDasgupta%2C+Abhijit%3BMann%2C+Felecia+E%3BFukuoka%2C+Junya%3BHames%2C+Megan%3BBergen%2C+Andrew+W%3BMurphy%2C+Sharon+E%3BYang%2C+Ping%3BPesatori%2C+Angela+C%3BConsonni%2C+Dario%3BBertazzi%2C+Pier+Alberto%3BWacholder%2C+Sholom%3BShih%2C+Joanna+H%3BCaporaso%2C+Neil+E%3BJen%2C+Jin&rft.aulast=Landi&rft.aufirst=Maria&rft.date=2008-02-20&rft.volume=3&rft.issue=2&rft.spage=e1651&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0001651 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-15 N1 - Date created - 2008-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2000 Jan;82(1):65-73 [10638968] Nat Med. 2007 Jul;13(7):820-7 [17589519] Nat Genet. 2000 May;25(1):25-9 [10802651] Cancer Res. 2000 Nov 1;60(21):6116-33 [11085536] Cancer Res. 2002 Jun 1;62(11):3244-50 [12036940] J Cell Biol. 2002 Aug 19;158(4):617-23 [12177045] Nat Cell Biol. 2002 Dec;4(12):976-80 [12447387] Genome Biol. 2003;4(4):R28 [12702209] Am J Respir Cell Mol Biol. 2003 Aug;29(2):157-62 [12600827] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):445-53 [15006922] J Biol Chem. 2004 May 7;279(19):20049-57 [14978040] Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10143-8 [15210990] J Cell Biol. 2004 Sep 27;166(7):949-55 [15452138] Chest. 2007 Jul;132(1):185-92 [17573517] Mol Biol Cell. 2007 Oct;18(10):4024-36 [17671160] Proc Am Thorac Soc. 2007 Jan;4(1):127-32 [17202302] Cancer Res. 1999 Feb 1;59(3):590-6 [9973205] Nat Rev Cancer. 2004 Dec;4(12):927-36 [15573114] Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30 [15983384] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 [16199517] Am J Respir Crit Care Med. 2005 Dec 1;172(11):1383-92 [16166618] J Mol Med (Berl). 2006 Apr;84(4):318-28 [16520944] Bioinformatics. 2006 Apr 15;22(8):943-9 [16473874] J Pathol. 2006 Oct;210(2):192-204 [16915569] J Mol Med (Berl). 2007 Jan;85(1):39-53 [17115125] Nat Rev Cancer. 2007 Mar;7(3):169-81 [17318210] Carcinogenesis. 2007 May;28(5):899-912 [17259655] Cancer Res. 2000 Apr 1;60(7):1949-60 [10766185] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0001651 ER - TY - CPAPER T1 - Blood-Brain Barrier Disruption in Acute Stroke Prior to Therapy is Evident on Immediate Postcontrast FLAIR MRI. T2 - 2008 International Stroke Conference AN - 40880157; 4830095 JF - 2008 International Stroke Conference AU - Latour, Lawrence L AU - Kidwell, Chelsea S AU - Lee, Kyung-Yul AU - Schaewe, Timothy J AU - Merino, Jose G AU - Warach, Steven Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 KW - Stroke KW - Magnetic resonance imaging KW - Blood-brain barrier KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40880157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Stroke+Conference&rft.atitle=Blood-Brain+Barrier+Disruption+in+Acute+Stroke+Prior+to+Therapy+is+Evident+on+Immediate+Postcontrast+FLAIR+MRI.&rft.au=Latour%2C+Lawrence+L%3BKidwell%2C+Chelsea+S%3BLee%2C+Kyung-Yul%3BSchaewe%2C+Timothy+J%3BMerino%2C+Jose+G%3BWarach%2C+Steven&rft.aulast=Latour&rft.aufirst=Lawrence&rft.date=2008-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/sc_includes/pdfs/iscFinalPro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Benefit of Desmoteplase Treatment in Patients with Moderate to Severe Stroke: Further Results of the DIAS-2 Trial. T2 - 2008 International Stroke Conference AN - 40879500; 4830797 JF - 2008 International Stroke Conference AU - Warach, Steven Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 KW - Stroke KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40879500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Stroke+Conference&rft.atitle=Clinical+Benefit+of+Desmoteplase+Treatment+in+Patients+with+Moderate+to+Severe+Stroke%3A+Further+Results+of+the+DIAS-2+Trial.&rft.au=Warach%2C+Steven&rft.aulast=Warach&rft.aufirst=Steven&rft.date=2008-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/sc_includes/pdfs/iscFinalPro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SPECTRM Stroke Patients Eligible for Clinical Trials: A Regression Model. T2 - 2008 International Stroke Conference AN - 40878340; 4830197 JF - 2008 International Stroke Conference AU - Taylor, Alexis M AU - Castle, Amanda B AU - Hsia, Amie W AU - Merino, Jose G AU - Kidwell, Chelsea S AU - Warach, Steven Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 KW - Clinical trials KW - Stroke KW - Regression analysis KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40878340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Stroke+Conference&rft.atitle=SPECTRM+Stroke+Patients+Eligible+for+Clinical+Trials%3A+A+Regression+Model.&rft.au=Taylor%2C+Alexis+M%3BCastle%2C+Amanda+B%3BHsia%2C+Amie+W%3BMerino%2C+Jose+G%3BKidwell%2C+Chelsea+S%3BWarach%2C+Steven&rft.aulast=Taylor&rft.aufirst=Alexis&rft.date=2008-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/sc_includes/pdfs/iscFinalPro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small Cortical Lesions Visible on Acute DWI are Not Visible on 90-Day FLAIR. T2 - 2008 International Stroke Conference AN - 40878168; 4830158 JF - 2008 International Stroke Conference AU - Benameur, Karima AU - Merino, Jose AU - Kidwell, Chelsea S AU - Warach, Steven AU - Latour, Lawrence Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 KW - Lesions KW - Cortex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40878168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Stroke+Conference&rft.atitle=Small+Cortical+Lesions+Visible+on+Acute+DWI+are+Not+Visible+on+90-Day+FLAIR.&rft.au=Benameur%2C+Karima%3BMerino%2C+Jose%3BKidwell%2C+Chelsea+S%3BWarach%2C+Steven%3BLatour%2C+Lawrence&rft.aulast=Benameur&rft.aufirst=Karima&rft.date=2008-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/sc_includes/pdfs/iscFinalPro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mucosal Tolerance to E-Selectin Promotes the Survival of Newly Generated Neuroblasts via Regulatory T-Cell Induction after Stroke. T2 - 2008 International Stroke Conference AN - 40876855; 4830444 JF - 2008 International Stroke Conference AU - Ishibashi, Satoru AU - Maric, Dragan AU - Ohtani, Ryo AU - Lee-Wickner, Yang-ja AU - Mou, Yongshan AU - Hallenbeck, John M Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 KW - Survival KW - Stroke KW - Lymphocytes T KW - Immunological tolerance KW - E-selectin KW - Mucosa KW - Neuroblasts KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40876855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Stroke+Conference&rft.atitle=Mucosal+Tolerance+to+E-Selectin+Promotes+the+Survival+of+Newly+Generated+Neuroblasts+via+Regulatory+T-Cell+Induction+after+Stroke.&rft.au=Ishibashi%2C+Satoru%3BMaric%2C+Dragan%3BOhtani%2C+Ryo%3BLee-Wickner%2C+Yang-ja%3BMou%2C+Yongshan%3BHallenbeck%2C+John+M&rft.aulast=Ishibashi&rft.aufirst=Satoru&rft.date=2008-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/sc_includes/pdfs/iscFinalPro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parenchymal Enhancement on T1-Weighted MRI Predicts Subsequent Hemorrhagic Transformation in Acute Ischemic Stroke. T2 - 2008 International Stroke Conference AN - 40875586; 4830165 JF - 2008 International Stroke Conference AU - Lee, Kyung-Yul AU - Latour, Lawrence L AU - Merino, Jose G AU - Warach, Steven Y1 - 2008/02/20/ PY - 2008 DA - 2008 Feb 20 KW - Stroke KW - Ischemia KW - Magnetic resonance imaging KW - Hemorrhage KW - Transformation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40875586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Stroke+Conference&rft.atitle=Parenchymal+Enhancement+on+T1-Weighted+MRI+Predicts+Subsequent+Hemorrhagic+Transformation+in+Acute+Ischemic+Stroke.&rft.au=Lee%2C+Kyung-Yul%3BLatour%2C+Lawrence+L%3BMerino%2C+Jose+G%3BWarach%2C+Steven&rft.aulast=Lee&rft.aufirst=Kyung-Yul&rft.date=2008-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/sc_includes/pdfs/iscFinalPro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. AN - 70321367; 18287083 AB - Caloric restriction (CR) is the most potent intervention known to both protect against carcinogenesis and extend lifespan in laboratory animals. A variety of anticarcinogens and CR mimetics induce and activate the NF-E2-related factor 2 (Nrf2) pathway. Nrf2, in turn, induces a number of antioxidative and carcinogen-detoxifying enzymes. Thus, Nrf2 offers a promising target for anticarcinogenesis and antiaging interventions. We used Nrf2-disrupted (KO) mice to examine its role on the biological effects of CR. Here, we show that Nrf2 is responsible for most of the anticarcinogenic effects of CR, but is dispensable for increased insulin sensitivity and lifespan extension. Nrf2-deficient mice developed tumors more readily in response to carcinogen exposure than did WT mice, and CR was ineffective in suppressing tumors in the KO mice. However, CR extended lifespan and increased insulin sensitivity similarly in KO and WT mice. These findings identify a molecular pathway that dissociates the prolongevity and anticarcinogenic effects of CR. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Pearson, Kevin J AU - Lewis, Kaitlyn N AU - Price, Nathan L AU - Chang, Joy W AU - Perez, Evelyn AU - Cascajo, Maria Victoria AU - Tamashiro, Kellie L AU - Poosala, Suresh AU - Csiszar, Anna AU - Ungvari, Zoltan AU - Kensler, Thomas W AU - Yamamoto, Masayuki AU - Egan, Josephine M AU - Longo, Dan L AU - Ingram, Donald K AU - Navas, Placido AU - de Cabo, Rafael AD - Laboratories of Experimental Gerontology, Clinical Investigation, and Immunology and Research Resources Branch, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2008/02/19/ PY - 2008 DA - 2008 Feb 19 SP - 2325 EP - 2330 VL - 105 IS - 7 KW - Insulin KW - 0 KW - NF-E2-Related Factor 2 KW - NAD(P)H Dehydrogenase (Quinone) KW - EC 1.6.5.2 KW - Nqo1 protein, mouse KW - NADPH Dehydrogenase KW - EC 1.6.99.1 KW - Index Medicus KW - Sensitivity and Specificity KW - NADPH Dehydrogenase -- metabolism KW - Animals KW - NADPH Dehydrogenase -- genetics KW - Survival Rate KW - Longevity -- physiology KW - Insulin -- metabolism KW - Mice KW - Gene Expression Regulation KW - Mice, Knockout KW - NF-E2-Related Factor 2 -- genetics KW - Caloric Restriction KW - Neoplasms -- prevention & control KW - NF-E2-Related Factor 2 -- deficiency KW - Neoplasms -- genetics KW - Neoplasms -- metabolism KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70321367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Nrf2+mediates+cancer+protection+but+not+prolongevity+induced+by+caloric+restriction.&rft.au=Pearson%2C+Kevin+J%3BLewis%2C+Kaitlyn+N%3BPrice%2C+Nathan+L%3BChang%2C+Joy+W%3BPerez%2C+Evelyn%3BCascajo%2C+Maria+Victoria%3BTamashiro%2C+Kellie+L%3BPoosala%2C+Suresh%3BCsiszar%2C+Anna%3BUngvari%2C+Zoltan%3BKensler%2C+Thomas+W%3BYamamoto%2C+Masayuki%3BEgan%2C+Josephine+M%3BLongo%2C+Dan+L%3BIngram%2C+Donald+K%3BNavas%2C+Placido%3Bde+Cabo%2C+Rafael&rft.aulast=Pearson&rft.aufirst=Kevin&rft.date=2008-02-19&rft.volume=105&rft.issue=7&rft.spage=2325&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0712162105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-13 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Jul 21;275(29):22166-71 [10764775] Nature. 2007 May 31;447(7144):545-9 [17538612] J Biol Chem. 2001 Jun 22;276(25):22559-64 [11309386] J Natl Cancer Inst. 2001 Aug 1;93(15):1166-70 [11481389] Ann N Y Acad Sci. 2001 Apr;928:305-15 [11795522] Methods Enzymol. 2002;348:182-90 [11885271] Hybrid Hybridomics. 2002 Apr;21(2):147-51 [12031105] Mol Pharmacol. 2002 Nov;62(5):1001-10 [12391262] Biochem J. 2003 May 1;371(Pt 3):887-95 [12570874] Genes Dev. 2003 Aug 1;17(15):1882-93 [12869585] Physiol Genomics. 2003 Dec 16;16(1):29-37 [14679299] Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3381-6 [14985508] Proc Natl Acad Sci U S A. 1984 Dec;81(23):7596-8 [6594701] EMBO J. 1985 Jun;4(6):1491-4 [4029121] J Nutr. 1986 Apr;116(4):641-54 [3958810] Nature. 1986 Jul 3-9;322(6074):78-80 [3014349] Cancer Res. 1991 Apr 1;51(7):1851-4 [1900738] Jikken Dobutsu. 1991 Oct;40(4):517-22 [1748169] Nutrition. 1989 May-Jun;5(3):155-71; discussion 172 [2520283] Carcinogenesis. 1992 Oct;13(10):1925-8 [1423856] Aging (Milano). 1996 Apr;8(2):123-9 [8737611] Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22 [9240432] N Engl J Med. 1997 Oct 2;337(14):986-94 [9309105] Biochem Biophys Res Commun. 2005 Jun 17;331(4):993-1000 [15882976] Aging Cell. 2005 Oct;4(5):257-71 [16164425] Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16275-80 [16251270] Aging Cell. 2005 Dec;4(6):299-307 [16300482] Mol Cell Biol. 2006 May;26(10):3773-84 [16648473] FEBS J. 2006 Jun;273(11):2345-56 [16704410] Cancer Res. 2006 Aug 15;66(16):8293-6 [16912211] Med Chem. 2006 May;2(3):275-85 [16948474] Adv Enzyme Regul. 2006;46:113-40 [16887173] Cancer Res. 2006 Sep 1;66(17):8421-9 [16951152] Interdiscip Top Gerontol. 2007;35:69-82 [17063033] Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19908-12 [17167053] Pharmacol Ther. 2007 Jan;113(1):88-120 [17097148] Biogerontology. 2007 Apr;8(2):71-80 [16850181] Free Radic Biol Med. 2007 Jun 1;42(11):1690-703 [17462537] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5 [11248092] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0712162105 ER - TY - JOUR T1 - Transmission of Kaposi sarcoma-associated herpesvirus in sub-Saharan Africa AN - 21041570; 8127775 AB - Kaposi sarcoma-associated herpesvirus (KSHV, also called human herpesvirus 8; HHV8) is a necessary, but insufficient, cause of Kaposi sarcoma (KS). KS is endemic in parts of Africa and also occurs opportunistically among individuals with AIDS. In HIV-negative, KSHV-seropositive adults from the Mediterranean area over the age of 50 years, approximately one in 3000 men and less than half as many women develop KS per year. In contrast, one in 30 HIV-positive, KSHV-seropositive men who have sex with men (MSM) develop KS per year. This 100-fold increased risk of KS with HIV has amplified the incidence of KS in many populations of sub-Saharan Africa, where KSHV was endemic before the AIDS epidemic. In South Africa, one in three adults are KSHV seropositive and the risk of KS is increased more than 20-fold with HIV infection. With the HIV epidemic, KS has thus become the commonest cancer in children, women and men in many sub-Saharan African countries. Abating this KS epidemic will require concerted efforts to treat individuals with HIV/AIDS and to reduce HIV and KSHV transmission. JF - AIDS AU - Mbulaiteye, S M AU - Goedert, J J AD - 6120 Executive Boulevard, Room 7080 Rockville, Maryland 20852 USA, mbulaits@mail.nih.gov Y1 - 2008/02/19/ PY - 2008 DA - 2008 Feb 19 SP - 535 EP - 537 VL - 22 IS - 4 SN - 0269-9370, 0269-9370 KW - Immunology Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Age KW - Epidemics KW - Human herpesvirus 8 KW - Kaposi's sarcoma-associated herpesvirus KW - homosexuality KW - Infection KW - Children KW - Cancer KW - Disease transmission KW - Infectious diseases KW - Human immunodeficiency virus KW - MED KW - Sarcoma KW - South Africa KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21041570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Transmission+of+Kaposi+sarcoma-associated+herpesvirus+in+sub-Saharan+Africa&rft.au=Mbulaiteye%2C+S+M%3BGoedert%2C+J+J&rft.aulast=Mbulaiteye&rft.aufirst=S&rft.date=2008-02-19&rft.volume=22&rft.issue=4&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Acquired immune deficiency syndrome; Epidemics; Sarcoma; Children; Infection; Disease transmission; Infectious diseases; homosexuality; Cancer; Human immunodeficiency virus; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus; MED; South Africa ER - TY - JOUR T1 - No evidence of sexual transmission of Kaposi's sarcoma herpes virus in a heterosexual South African population AN - 19474126; 8127772 AB - Background: The transmission of Kaposi's sarcoma herpes virus (KSHV) in men who have sex with men is clearly associated with sexual risk factors, but evidence of heterosexual transmission of KSHV is conflicting. Methods: Sera were obtained from 2103 South African individuals (862 miners, 95 sex workers, 731 female and 415 male township residents; mean age 33.2 years; plus or minus 10.1). All sera were tested for antibodies to KSHV lytic K8.1 and latent Orf73, HIV, gonococcus, herpes simplex virus type 2 (HSV-2), syphilis and chlamydia. Information on social, demographic and high-risk sexual behavior was linked to laboratory data, to evaluate risk factors, expressed as odds ratios (95% confidence interval) for KSHV. Results: Overall KSHV and HIV prevalences were 47.5 and 40%, respectively (P=0.43). The risk of HIV infection was highest in sex workers then female residents and miners, compared with male residents (P0.05). KSHV was not associated with any of the STI or any measures of sexual behavior (P>0.05). Conclusion: The pattern of HIV and STI in sex workers suggests high rates of high-risk sexual behavior in this population. The lack of association with high-risk sexual behavior, particularly in sex workers, and with any markers of STI strongly suggest that the sexual mode does not play a significant role in KSHV transmission in this South African population. JF - AIDS AU - Malope, B I AU - MacPhail, P AU - Mbisa, G AU - MacPhail, C AU - Stein, L AU - Ratshikhopha, E M AU - Ndhlovu, L AU - Sitas, F AU - Whitby, D AD - Viral Oncology Section, AIDS Vaccine Program, SAIC-Frederick, NCI-Frederick, Frederick MD, USA, whitbyd@ncifcrf.gov Y1 - 2008/02/19/ PY - 2008 DA - 2008 Feb 19 SP - 519 EP - 526 VL - 22 IS - 4 SN - 0269-9370, 0269-9370 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Health & Safety Science Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - demography KW - sexual behavior KW - Acquired immune deficiency syndrome KW - Age KW - Herpesvirus KW - Occupational safety KW - homosexuality KW - Infection KW - Herpes simplex KW - Sexual behavior KW - Disease transmission KW - Demography KW - infectious diseases KW - Risk factors KW - Treponema pallidum KW - infection KW - Risk groups KW - Syphilis KW - sexually transmitted diseases KW - Chlamydia KW - Data processing KW - Kaposi's sarcoma-associated herpesvirus KW - Prostitution KW - Herpes simplex virus 2 KW - Antibodies KW - Kaposi's sarcoma KW - Human immunodeficiency virus KW - Mining KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - J 02400:Human Diseases KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19474126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=No+evidence+of+sexual+transmission+of+Kaposi%27s+sarcoma+herpes+virus+in+a+heterosexual+South+African+population&rft.au=Malope%2C+B+I%3BMacPhail%2C+P%3BMbisa%2C+G%3BMacPhail%2C+C%3BStein%2C+L%3BRatshikhopha%2C+E+M%3BNdhlovu%2C+L%3BSitas%2C+F%3BWhitby%2C+D&rft.aulast=Malope&rft.aufirst=B&rft.date=2008-02-19&rft.volume=22&rft.issue=4&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Prostitution; Infection; Sexual behavior; Herpes simplex; Disease transmission; Demography; Antibodies; Kaposi's sarcoma; Risk factors; Risk groups; Syphilis; demography; infectious diseases; sexual behavior; Acquired immune deficiency syndrome; Occupational safety; homosexuality; infection; Mining; sexually transmitted diseases; Human immunodeficiency virus; Herpesvirus; Treponema pallidum; Kaposi's sarcoma-associated herpesvirus; Herpes simplex virus 2; Chlamydia ER - TY - CPAPER T1 - Acetabular Rim and Surface Segmentation for HIP Surgery Planning and Dysplasia Evaluation T2 - Conference on Visualization, Image-guided Procedures, and Modeling (MI06) AN - 40719358; 4761854 JF - Conference on Visualization, Image-guided Procedures, and Modeling (MI06) AU - Tan, Sovira AU - Yao, Jianhua AU - Yao, Lawrence AU - Summers, Ronald M AU - Ward, Michael M Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Surgery KW - Segmentation KW - Acetabulum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Visualization%2C+Image-guided+Procedures%2C+and+Modeling+%28MI06%29&rft.atitle=Acetabular+Rim+and+Surface+Segmentation+for+HIP+Surgery+Planning+and+Dysplasia+Evaluation&rft.au=Tan%2C+Sovira%3BYao%2C+Jianhua%3BYao%2C+Lawrence%3BSummers%2C+Ronald+M%3BWard%2C+Michael+M&rft.aulast=Tan&rft.aufirst=Sovira&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Visualization%2C+Image-guided+Procedures%2C+and+Modeling+%28MI06%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783658&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Java-based Volume Rendering T2 - Conference on Visualization, Image-guided Procedures, and Modeling (MI06) AN - 40717980; 4761747 DE: JF - Conference on Visualization, Image-guided Procedures, and Modeling (MI06) AU - Cheng, Ruida AU - Bokinsky, Alexandra AU - Hemler, Paul F AU - McCreedy, Evan S AU - McAuliffe, Matthew J Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Visualization%2C+Image-guided+Procedures%2C+and+Modeling+%28MI06%29&rft.atitle=Java-based+Volume+Rendering&rft.au=Cheng%2C+Ruida%3BBokinsky%2C+Alexandra%3BHemler%2C+Paul+F%3BMcCreedy%2C+Evan+S%3BMcAuliffe%2C+Matthew+J&rft.aulast=Cheng&rft.aufirst=Ruida&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Visualization%2C+Image-guided+Procedures%2C+and+Modeling+%28MI06%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783658&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automated Matching of Supine and Prone Colonic Polyps Based on PCA and SVMs T2 - Conference on Computer-Aided Diagnosis (MI03) AN - 40717832; 4761493 JF - Conference on Computer-Aided Diagnosis (MI03) AU - Wang, Shijun AU - Summers, Ronald M Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Polyps KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.atitle=Automated+Matching+of+Supine+and+Prone+Colonic+Polyps+Based+on+PCA+and+SVMs&rft.au=Wang%2C+Shijun%3BSummers%2C+Ronald+M&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783653&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Semi-Synthetic Digital Phantoms Incorporating Natural Structured Noise and Boundary Inhomogeneities T2 - Conference on Image Processing (MI02) AN - 40717708; 4761462 JF - Conference on Image Processing (MI02) AU - Tan, Sovira AU - Ward, Michael M Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Boundaries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Processing+%28MI02%29&rft.atitle=Semi-Synthetic+Digital+Phantoms+Incorporating+Natural+Structured+Noise+and+Boundary+Inhomogeneities&rft.au=Tan%2C+Sovira%3BWard%2C+Michael+M&rft.aulast=Tan&rft.aufirst=Sovira&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Processing+%28MI02%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783651&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Semi-Automatic Segmentation and Modeling of the Cervical Spinal Cord for Volume Quantification in Multiple Sclerosis Patients from Magnetic Resonance Images T2 - Conference on Image Processing (MI02) AN - 40717597; 4761448 JF - Conference on Image Processing (MI02) AU - Sonkova, Pavlina AU - Evangelou, Iordanis E AU - Gallo, Antonio AU - Joan, Ohayon R.N. AU - McFarland, Henry F AU - Bagnato, Francesca Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Spinal cord KW - Magnetic resonance imaging KW - Segmentation KW - Image processing KW - Multiple sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Processing+%28MI02%29&rft.atitle=Semi-Automatic+Segmentation+and+Modeling+of+the+Cervical+Spinal+Cord+for+Volume+Quantification+in+Multiple+Sclerosis+Patients+from+Magnetic+Resonance+Images&rft.au=Sonkova%2C+Pavlina%3BEvangelou%2C+Iordanis+E%3BGallo%2C+Antonio%3BJoan%2C+Ohayon+R.N.%3BMcFarland%2C+Henry+F%3BBagnato%2C+Francesca&rft.aulast=Sonkova&rft.aufirst=Pavlina&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Processing+%28MI02%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783651&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MR-guided Catheter-based Excitation Emission Optical Spectroscopy for In Vivo Tissue Characterization T2 - Conference on Visualization, Image-guided Procedures, and Modeling (MI06) AN - 40717217; 4761786 JF - Conference on Visualization, Image-guided Procedures, and Modeling (MI06) AU - Herzka, Daniel A AU - Kotys, Melanie S AU - Krueger, Sascha AU - Traughber, Bryan J AU - Heroux, Julie AU - Gharib, Ahmed M AU - Ohayon, Jacques AU - Weiss, Steffen AU - Pettigrew, Roderic I AU - Wood, Bradford J Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Spectroscopy KW - Emissions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Visualization%2C+Image-guided+Procedures%2C+and+Modeling+%28MI06%29&rft.atitle=MR-guided+Catheter-based+Excitation+Emission+Optical+Spectroscopy+for+In+Vivo+Tissue+Characterization&rft.au=Herzka%2C+Daniel+A%3BKotys%2C+Melanie+S%3BKrueger%2C+Sascha%3BTraughber%2C+Bryan+J%3BHeroux%2C+Julie%3BGharib%2C+Ahmed+M%3BOhayon%2C+Jacques%3BWeiss%2C+Steffen%3BPettigrew%2C+Roderic+I%3BWood%2C+Bradford+J&rft.aulast=Herzka&rft.aufirst=Daniel&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Visualization%2C+Image-guided+Procedures%2C+and+Modeling+%28MI06%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783658&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glycoprotein Expression by Adenomatous Polyps of the Colon T2 - Conference on Physiology, Function, and Structure from Medical Images (MI04) AN - 40716057; 4761649 JF - Conference on Physiology, Function, and Structure from Medical Images (MI04) AU - Roney, Celeste A AU - Xie, Jianwu AU - Jabour, Paul AU - Summers, Ronald M Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Glycoproteins KW - Polyps KW - Colon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40716057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Physiology%2C+Function%2C+and+Structure+from+Medical+Images+%28MI04%29&rft.atitle=Glycoprotein+Expression+by+Adenomatous+Polyps+of+the+Colon&rft.au=Roney%2C+Celeste+A%3BXie%2C+Jianwu%3BJabour%2C+Paul%3BSummers%2C+Ronald+M&rft.aulast=Roney&rft.aufirst=Celeste&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Physiology%2C+Function%2C+and+Structure+from+Medical+Images+%28MI04%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783654&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three-Dimensional Reconstruction of the Moving Mitral Valve Annulus and Mitral Valve Leaflets from Multislice 2D Magnetic Resonance Images Acquired Using a Balanced Steady-State Free Precession Imaging Pulse Sequence T2 - Conference on Physiology, Function, and Structure from Medical Images (MI04) AN - 40715603; 4761644 JF - Conference on Physiology, Function, and Structure from Medical Images (MI04) AU - Sampath, Smita AU - Kim, June H AU - Lederman, Robert J AU - McVeigh, Elliot R Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Mitral valve KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Physiology%2C+Function%2C+and+Structure+from+Medical+Images+%28MI04%29&rft.atitle=Three-Dimensional+Reconstruction+of+the+Moving+Mitral+Valve+Annulus+and+Mitral+Valve+Leaflets+from+Multislice+2D+Magnetic+Resonance+Images+Acquired+Using+a+Balanced+Steady-State+Free+Precession+Imaging+Pulse+Sequence&rft.au=Sampath%2C+Smita%3BKim%2C+June+H%3BLederman%2C+Robert+J%3BMcVeigh%2C+Elliot+R&rft.aulast=Sampath&rft.aufirst=Smita&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Physiology%2C+Function%2C+and+Structure+from+Medical+Images+%28MI04%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783654&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Artery Segmentation and Quantification in Sickle Cell Associated Pulmonary Hypertension T2 - Conference on Physiology, Function, and Structure from Medical Images (MI04) AN - 40715351; 4761672 JF - Conference on Physiology, Function, and Structure from Medical Images (MI04) AU - Linguraru, Marius G AU - Mukherjee, Nisha AU - Van Uitert, Robert L AU - Summers, Ronald M AU - Machado, Roberto F AU - Wood, Bradford J AU - Gladwin, Mark T Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Hypertension KW - Segmentation KW - Lung KW - Pulmonary artery KW - Circulatory system KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Physiology%2C+Function%2C+and+Structure+from+Medical+Images+%28MI04%29&rft.atitle=Pulmonary+Artery+Segmentation+and+Quantification+in+Sickle+Cell+Associated+Pulmonary+Hypertension&rft.au=Linguraru%2C+Marius+G%3BMukherjee%2C+Nisha%3BVan+Uitert%2C+Robert+L%3BSummers%2C+Ronald+M%3BMachado%2C+Roberto+F%3BWood%2C+Bradford+J%3BGladwin%2C+Mark+T&rft.aulast=Linguraru&rft.aufirst=Marius&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Physiology%2C+Function%2C+and+Structure+from+Medical+Images+%28MI04%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783654&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Scale-Based Scatter Correction for Computer-Aided Polyp Detection in CT Colonography T2 - Conference on Computer-Aided Diagnosis (MI03) AN - 40715107; 4761552 JF - Conference on Computer-Aided Diagnosis (MI03) AU - Liu, Jiamin AU - Yao, Jianhua AU - Summers, Ronald M Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Polyps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.atitle=Scale-Based+Scatter+Correction+for+Computer-Aided+Polyp+Detection+in+CT+Colonography&rft.au=Liu%2C+Jiamin%3BYao%2C+Jianhua%3BSummers%2C+Ronald+M&rft.aulast=Liu&rft.aufirst=Jiamin&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783653&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DMLLE: A Large-Scale Dimensionality Reduction Method for Detection of Polyps in CT Colonography T2 - Conference on Computer-Aided Diagnosis (MI03) AN - 40714731; 4761494 JF - Conference on Computer-Aided Diagnosis (MI03) AU - Wang, Shijun AU - Yao, Jianhua AU - Summers, Ronald M Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Polyps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.atitle=DMLLE%3A+A+Large-Scale+Dimensionality+Reduction+Method+for+Detection+of+Polyps+in+CT+Colonography&rft.au=Wang%2C+Shijun%3BYao%2C+Jianhua%3BSummers%2C+Ronald+M&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Computer-Aided+Diagnosis+%28MI03%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783653&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polyp Height and Width Measurement Using Topographic Height Map T2 - Conference on Physiology, Function, and Structure from Medical Images (MI04) AN - 40713179; 4761621 JF - Conference on Physiology, Function, and Structure from Medical Images (MI04) AU - Yao, Jianhua AU - Frentz, Suzanne AU - Li, Jiang AU - Summers, Ronald M Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Polyps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40713179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Physiology%2C+Function%2C+and+Structure+from+Medical+Images+%28MI04%29&rft.atitle=Polyp+Height+and+Width+Measurement+Using+Topographic+Height+Map&rft.au=Yao%2C+Jianhua%3BFrentz%2C+Suzanne%3BLi%2C+Jiang%3BSummers%2C+Ronald+M&rft.aulast=Yao&rft.aufirst=Jianhua&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Physiology%2C+Function%2C+and+Structure+from+Medical+Images+%28MI04%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783654&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vertebral Surface Registration Using Ridgelines/Crestlines T2 - Conference on Image Processing (MI02) AN - 40712045; 4761321 JF - Conference on Image Processing (MI02) AU - Tan, Sovira AU - Yao, Jianhua AU - Yao, Lawrence AU - Summers, Ronald M AU - Ward, Michael M Y1 - 2008/02/16/ PY - 2008 DA - 2008 Feb 16 KW - Vertebrae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40712045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Conference+on+Image+Processing+%28MI02%29&rft.atitle=Vertebral+Surface+Registration+Using+Ridgelines%2FCrestlines&rft.au=Tan%2C+Sovira%3BYao%2C+Jianhua%3BYao%2C+Lawrence%3BSummers%2C+Ronald+M%3BWard%2C+Michael+M&rft.aulast=Tan&rft.aufirst=Sovira&rft.date=2008-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Conference+on+Image+Processing+%28MI02%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/app/program/index.cfm?fuseaction=conferencedetail&expo rt_id=x12534&ID=x12171&redir=x12171.xml&conference_id=783651&event_i d=783639 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation. AN - 70300970; 18191113 AB - Alterations in inflammatory process, neuronal death, and glia response have been observed under manipulation of interleukin-1 (IL-1) and subsequent signaling through the type 1 IL-1 receptor (IL-1R1). To investigate the influence of IL-1R1 activation in the pathophysiology of a chemical-induced injury to the murine hippocampus, we examined the level and pattern of neuronal death and neuroinflammation in male weanling mice exposed to trimethyltin hydroxide (2.0 mg TMT/kg, i.p.). Dentate granule cell death occurred at 6 h post-TMT as detected by active caspase 3 immunostaining and presence of lectin positive microglia. The severity of neuronal death and microglia response increased by 12-24 h with elevations in mRNA levels for TNFalpha and IL-1alpha. In IL-1R1 null (IL-1R1-/-) mice, the pattern and severity of neuronal death at 24 or 72 h post-TMT was similar as compared to wildtype (WT) mice. In both groups, mRNA levels for TNFalpha and MIP-1alpha were elevated, no significant change was seen in either IL-1alpha or IL-1beta, and the early activation of microglia, including their ability to progress to a phagocytic phenotype, was maintained. Compared to WT mice, IL-1R1-/- mice displayed a limited glial fibrillary acidic protein (GFAP) astrocytic response, as well as a preferential induction in mRNA levels of Fas signaling components. Cumulatively, these results indicate that IL-1R1 activation is not necessary for TMT-induced death of dentate granule neurons or local activation of microglia; however, IL-1R1 signaling is involved in mediating the structural response of astrocytes to injury and may regulate apoptotic mechanisms via Fas signaling components. JF - Brain research AU - Harry, G Jean AU - Funk, Jason A AU - Lefebvre d'Hellencourt, Christian AU - McPherson, Christopher A AU - Aoyama, Mineyoshi AD - Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov Y1 - 2008/02/15/ PY - 2008 DA - 2008 Feb 15 SP - 8 EP - 20 VL - 1194 SN - 0006-8993, 0006-8993 KW - Apoptosis Regulatory Proteins KW - 0 KW - Glial Fibrillary Acidic Protein KW - Interleukin-1alpha KW - Lectins KW - Myd88 protein, mouse KW - Myeloid Differentiation Factor 88 KW - Receptors, Interleukin-1 KW - Trimethyltin Compounds KW - Tumor Necrosis Factor-alpha KW - trimethyltin hydroxide KW - 56-24-6 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Myeloid Differentiation Factor 88 -- metabolism KW - Animals KW - Cell Death -- physiology KW - Apoptosis Regulatory Proteins -- genetics KW - Trimethyltin Compounds -- pharmacology KW - Random Allocation KW - Interleukin-1alpha -- metabolism KW - Glial Fibrillary Acidic Protein -- metabolism KW - Mice KW - Cell Death -- drug effects KW - Tumor Necrosis Factor-alpha -- genetics KW - Mice, Knockout KW - Gene Expression Regulation -- genetics KW - Apoptosis Regulatory Proteins -- metabolism KW - Mice, Inbred C57BL KW - Gene Expression Regulation -- drug effects KW - Tumor Necrosis Factor-alpha -- metabolism KW - Time Factors KW - Male KW - Lectins -- metabolism KW - Caspase 3 -- metabolism KW - Interleukin-1alpha -- genetics KW - Receptors, Interleukin-1 -- deficiency KW - Microglia -- physiology KW - Neurons -- drug effects KW - Neurons -- physiology KW - Dentate Gyrus -- cytology KW - Receptors, Interleukin-1 -- physiology KW - Microglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70300970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=The+type+1+interleukin+1+receptor+is+not+required+for+the+death+of+murine+hippocampal+dentate+granule+cells+and+microglia+activation.&rft.au=Harry%2C+G+Jean%3BFunk%2C+Jason+A%3BLefebvre+d%27Hellencourt%2C+Christian%3BMcPherson%2C+Christopher+A%3BAoyama%2C+Mineyoshi&rft.aulast=Harry&rft.aufirst=G&rft.date=2008-02-15&rft.volume=1194&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/10.1016%2Fj.brainres.2007.11.076 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-30 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell Growth Differ. 1999 Dec;10(12):797-804 [10616904] Brain Res. 1995 Feb 13;671(2):261-6 [7743213] Neuroimmunomodulation. 2000;7(3):153-9 [10754403] Cytokine. 2000 May;12(5):423-31 [10857755] J Neurosci. 2000 Sep 15;20(18):6811-9 [10995825] Trends Neurosci. 2000 Dec;23(12):618-25 [11137152] Exp Neurol. 2001 Mar;168(1):23-31 [11170718] J Neurosci. 2001 Aug 1;21(15):5528-34 [11466424] Brain Res. 2001 Sep 7;912(2):116-27 [11532427] Nat Rev Neurosci. 2001 Oct;2(10):734-44 [11584311] J Neurosci Res. 2001 Nov 1;66(3):464-74 [11746364] J Neurosci. 2002 Jan 1;22(1):38-43 [11756486] J Neurosci. 1995 May;15(5 Pt 1):3468-74 [7538561] J Biol Chem. 1995 Jun 9;270(23):13757-65 [7775431] Am J Pathol. 1995 Nov;147(5):1477-86 [7485410] J Comp Neurol. 1995 Oct 30;361(4):681-98 [8576422] Blood. 1996 Mar 15;87(6):2095-147 [8630372] Neuroimmunomodulation. 1995 May-Jun;2(3):121-33 [8646560] FEBS Lett. 1996 Oct 7;394(3):273-8 [8830657] J Cereb Blood Flow Metab. 1996 Nov;16(6):1137-42 [8898685] Neuroreport. 1996 Sep 2;7(13):2181-5 [8930985] Biochem Biophys Res Commun. 1997 May 8;234(1):211-5 [9168991] Immunity. 1997 Dec;7(6):837-47 [9430229] J Neurosci Res. 1998 Apr 1;52(1):7-16 [9556025] J Leukoc Biol. 1998 Jun;63(6):650-7 [9620655] J Neurochem. 1998 Oct;71(4):1577-87 [9751191] J Cereb Blood Flow Metab. 1999 Jan;19(1):87-98 [9886359] J Neurochem. 1999 Apr;72(4):1353-61 [10098836] Neurosci Res. 1999 Apr;33(4):251-60 [10401977] Neuroscience. 1999;93(3):915-30 [10473257] Exp Neurol. 2005 Jan;191(1):145-53 [15589521] J Cereb Blood Flow Metab. 2005 Jan;25(1):17-29 [15678109] Neurotox Res. 2005;7(3):183-92 [15897153] Nat Rev Immunol. 2005 Aug;5(8):629-40 [16034365] Glia. 2006 Apr 1;53(5):551-6 [16374779] Am J Clin Nutr. 2006 Feb;83(2):470S-474S [16470015] J Neuroimmunol. 2006 Jun;175(1-2):97-106 [16626814] Int J Mol Med. 2006 Jul;18(1):33-9 [16786153] J Neurochem. 2006 Jul;98(1):258-66 [16805812] Stroke. 2005 Oct;36(10):2226-31 [16179572] Neuroscience. 2006;137(1):301-8 [16289587] Methods. 2001 Dec;25(4):402-8 [11846609] Br J Pharmacol. 2002 May;136(2):312-20 [12010781] Toxicol Appl Pharmacol. 2002 May 1;180(3):205-18 [12009860] J Neurosci. 2002 Jul 15;22(14):6071-82 [12122068] J Neuroimmunol. 2002 Nov;132(1-2):60-5 [12417434] Neuroimmunomodulation. 2002-2003;10(4):199-207 [12584407] Brain Behav Immun. 2003 Jun;17(3):152-7 [12706413] Neurotoxicology. 2003 Jun;24(3):343-56 [12782100] J Neuroimmunol. 2003 Aug;141(1-2):141-9 [12965265] J Neurosci. 2003 Sep 24;23(25):8692-700 [14507968] Adv Exp Med Biol. 2004;548:57-68 [15250585] J Neurosci. 1988 Jul;8(7):2485-90 [2470873] Proc Natl Acad Sci U S A. 1989 Oct;86(19):7611-5 [2529544] J Neurochem. 1992 Feb;58(2):454-60 [1729393] J Neurosci. 1992 Mar;12(3):1101-14 [1532025] J Cell Biol. 1992 Apr;117(2):395-400 [1560032] Brain Res. 1993 Nov 19;628(1-2):227-34 [8313151] Neuroscience. 1994 Feb;58(3):563-72 [8170537] Immunol Today. 1994 Dec;15(12):562-6 [7848516] Neurosci Lett. 1994 Oct 24;180(2):147-50 [7700568] Science. 1995 Apr 21;268(5209):411-5 [7536343] J Neuroimmunol. 1999 Dec;100(1-2):203-15 [10695731] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2007.11.076 ER - TY - JOUR T1 - Toxicology. Transforming environmental health protection. AN - 70294293; 18276874 JF - Science (New York, N.Y.) AU - Collins, Francis S AU - Gray, George M AU - Bucher, John R AD - National Human Genome Research Institute (NHGRI), National Institutes of Health, Bethesda, MD 20892, USA. francisc@mail.nih.gov Y1 - 2008/02/15/ PY - 2008 DA - 2008 Feb 15 SP - 906 EP - 907 VL - 319 IS - 5865 KW - Pesticides KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Public Health Service KW - United States Environmental Protection Agency KW - Computer Simulation KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Humans KW - Pharmacokinetics KW - Pesticides -- toxicity KW - Liver -- drug effects KW - National Institutes of Health (U.S.) KW - Databases, Factual KW - National Academy of Sciences (U.S.) KW - Models, Chemical KW - Drug Evaluation, Preclinical KW - Toxicity Tests -- methods KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70294293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Toxicology.+Transforming+environmental+health+protection.&rft.au=Collins%2C+Francis+S%3BGray%2C+George+M%3BBucher%2C+John+R&rft.aulast=Collins&rft.aufirst=Francis&rft.date=2008-02-15&rft.volume=319&rft.issue=5865&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/10.1126%2Fscience.1154619 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-28 N1 - Date created - 2008-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Pharmacol. 2007 Sep;152(1):53-61 [17603542] J Appl Toxicol. 2007 May-Jun;27(3):218-37 [17299829] Toxicol Sci. 2004 Dec;82(2):363-6 [15456919] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1126/science.1154619 ER - TY - JOUR T1 - Cutting edge: a cis-acting DNA element targets AID-mediated sequence diversification to the chicken Ig light chain gene locus. AN - 70264415; 18250404 AB - Somatic hypermutation and gene conversion are two closely related processes that increase the diversity of the primary Ig repertoire. Both processes are initiated by the activation-induced cytidine deaminase that converts cytosine residues to uracils in a transcription-dependent manner; these lesions are subsequently fixed in the genome by direct replication and error-prone DNA repair. Two alternative mechanisms were proposed to explain why this mutagenic activity is targeted almost exclusively to Ig loci: 1) specific cis-acting DNA sequences; or 2) very high levels of Ig gene transcription. In this study we now identify a novel 3' regulatory region in the chicken Ig light chain gene containing not only a classical transcriptional enhancer but also cis-acting DNA elements essential for targeting activation-induced cytidine deaminase-mediated sequence diversification to this locus. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Kothapalli, Nagarama AU - Norton, Darrell D AU - Fugmann, Sebastian D AD - Molecular Immunology Unit, Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2008/02/15/ PY - 2008 DA - 2008 Feb 15 SP - 2019 EP - 2023 VL - 180 IS - 4 SN - 0022-1767, 0022-1767 KW - Genetic Markers KW - 0 KW - Immunoglobulin Light Chains KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Chickens KW - Sequence Deletion -- immunology KW - Gene Conversion -- immunology KW - Somatic Hypermutation, Immunoglobulin -- genetics KW - Transcription, Genetic KW - Antibody Diversity -- genetics KW - Gene Targeting KW - Gene Conversion -- genetics KW - Mutagenesis, Insertional KW - Genetic Markers -- immunology KW - Cell Line KW - Regulatory Sequences, Nucleic Acid -- immunology KW - Immunoglobulin Light Chains -- metabolism KW - Cytidine Deaminase -- physiology KW - Enhancer Elements, Genetic -- genetics KW - Immunoglobulin Light Chains -- genetics KW - Enhancer Elements, Genetic -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70264415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Development+Studies&rft.atitle=Contract+Farming+and+Vulnerability+to+Poverty+among+Oil+Palm+Smallholders+in+Indonesia&rft.au=Cahyadi%2C+Eko+Ruddy%3BWaibel%2C+Hermann&rft.aulast=Cahyadi&rft.aufirst=Eko&rft.date=2016-05-01&rft.volume=52&rft.issue=5&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Development+Studies&rft.issn=00220388&rft_id=info:doi/10.1080%2F00220388.2015.1098627 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-17 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Initial synthesis and characterization of an immobilized heat shock protein 90 column for online determination of binding affinities. AN - 70186103; 18047824 AB - Heat shock protein 90 alpha (Hsp90alpha) was immobilized on aminopropyl silica via the N terminus to create the Hsp90alpha(NT) column or via the C terminus to create the Hsp90alpha(CT) column. Binding to the exposed C terminus on the Hsp90alpha(NT) column was characterized using frontal chromatography and the C-terminus ligands coumermycin A(1) (CA1) and novobiocin (NOVO). The calculated K(d) values were 220+/-110 nM (CA1) and 100+/-20 nM (NOVO). Nonlinear chromatography was used to determine the association and dissociation rate constants associated with the NOVO-Hsp90alpha complex: 22.2+/-8.8 microM(-1) s(-1) and 2.7+/-0.6s(-1), respectively. Binding to the exposed N terminus on the Hsp90alpha(CT) column was characterized using frontal chromatography. The K(d) values of the N-terminus ligands geldanamycin (GM, 90+/-50 nM), 17-allylamino-17-demethoxygeldanamycin (17-AAG, 210+/-50 nM), and radicicol (RAD, 20+/-9 nM) were consistent with previously reported values. The effect of the immobilization on ATPase activity was investigated through the determination of IC(50) values for inhibition of ATPase activity on the Hsp90alpha(CT) column. The IC(50) for GM was 2.80+/-0.18 microM, and the relative IC(50) values were 17-AAG>GM>RAD, in agreement with previously reported values and indicating that immobilization had not affected ATPase activity or sensitivity to inhibition. JF - Analytical biochemistry AU - Marszałł, Michał P AU - Moaddel, Ruin AU - Jozwiak, Krzysztof AU - Bernier, Michel AU - Wainer, Irving W AD - Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2008/02/15/ PY - 2008 DA - 2008 Feb 15 SP - 313 EP - 321 VL - 373 IS - 2 SN - 0003-2697, 0003-2697 KW - HSP90 Heat-Shock Proteins KW - 0 KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - Index Medicus KW - Adenosine Triphosphatases -- antagonists & inhibitors KW - Online Systems KW - Inhibitory Concentration 50 KW - HSP90 Heat-Shock Proteins -- isolation & purification KW - Chromatography, Liquid -- methods KW - HSP90 Heat-Shock Proteins -- chemistry KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70186103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+biochemistry&rft.atitle=Initial+synthesis+and+characterization+of+an+immobilized+heat+shock+protein+90+column+for+online+determination+of+binding+affinities.&rft.au=Marsza%C5%82%C5%82%2C+Micha%C5%82+P%3BMoaddel%2C+Ruin%3BJozwiak%2C+Krzysztof%3BBernier%2C+Michel%3BWainer%2C+Irving+W&rft.aulast=Marsza%C5%82%C5%82&rft.aufirst=Micha%C5%82&rft.date=2008-02-15&rft.volume=373&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Analytical+biochemistry&rft.issn=00032697&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-06 N1 - Date created - 2008-01-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Chem. 2002 Sep 15;74(18):4618-24 [12349962] Mol Cancer Ther. 2003 Feb;2(2):123-9 [12589029] Med Res Rev. 2007 Sep;27(5):723-53 [17238157] J Med Chem. 2007 Jun 14;50(12):2767-78 [17488003] Trends Biochem Sci. 2006 Mar;31(3):164-72 [16483782] Anal Chem. 2005 Dec 1;77(23):7512-9 [16316156] Nat Rev Cancer. 2005 Oct;5(10):761-72 [16175177] Anal Chem. 2005 Oct 1;77(19):6125-33 [16194069] Anal Chem. 2005 Aug 15;77(16):5421-6 [16097790] Nat Biotechnol. 2004 Nov;22(11):1445-8 [15502818] J Med Chem. 1999 Jan 28;42(2):260-6 [9925731] Biochem Pharmacol. 1973 Dec 1;22(23):3099-108 [4202581] Trends Mol Med. 2004 Feb;10(2):47-51 [15106614] Nature. 2003 Sep 25;425(6956):407-10 [14508491] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Nov 25;797(1-2):111-29 [14630146] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Nov 25;797(1-2):373-9 [14630163] Anal Biochem. 2004 Apr 15;327(2):176-83 [15051534] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screening. AN - 70275620; 18193825 AB - The G-protein-coupled receptor free fatty acid receptor 1 (FFAR1), previously named GPR40, is a possible novel target for the treatment of type 2 diabetes. In an attempt to identify new ligands for this receptor, we performed virtual screening (VS) based on two-dimensional (2D) similarity, three-dimensional (3D) pharmacophore searches, and docking studies by using the structure of known agonists and our model of the ligand binding site, which was validated by mutagenesis. VS of a database of 2.6 million compounds followed by extraction of structural neighbors of functionally confirmed hits resulted in identification of 15 compounds active at FFAR1 either as full agonists, partial agonists, or pure antagonists. Site-directed mutagenesis and docking studies revealed different patterns of ligand-receptor interactions and provided important information on the role of specific amino acids in binding and activation of FFAR1. JF - Journal of medicinal chemistry AU - Tikhonova, Irina G AU - Sum, Chi Shing AU - Neumann, Susanne AU - Engel, Stanislav AU - Raaka, Bruce M AU - Costanzi, Stefano AU - Gershengorn, Marvin C AD - Laboratory of Biological Modeling, and Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Y1 - 2008/02/14/ PY - 2008 DA - 2008 Feb 14 SP - 625 EP - 633 VL - 51 IS - 3 SN - 0022-2623, 0022-2623 KW - FFAR1 protein, human KW - 0 KW - Ligands KW - Receptors, G-Protein-Coupled KW - Thiadiazoles KW - Thiazolidines KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Stereoisomerism KW - Thiadiazoles -- chemistry KW - Drug Partial Agonism KW - Humans KW - Thiadiazoles -- pharmacology KW - Thiazolidines -- pharmacology KW - Binding Sites KW - Structure-Activity Relationship KW - Calcium -- metabolism KW - Thiazolidines -- chemistry KW - Databases, Factual KW - Mutation KW - Cell Line KW - Protein Conformation KW - Receptors, G-Protein-Coupled -- antagonists & inhibitors KW - Receptors, G-Protein-Coupled -- agonists KW - Receptors, G-Protein-Coupled -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70275620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Discovery+of+novel+agonists+and+antagonists+of+the+free+fatty+acid+receptor+1+%28FFAR1%29+using+virtual+screening.&rft.au=Tikhonova%2C+Irina+G%3BSum%2C+Chi+Shing%3BNeumann%2C+Susanne%3BEngel%2C+Stanislav%3BRaaka%2C+Bruce+M%3BCostanzi%2C+Stefano%3BGershengorn%2C+Marvin+C&rft.aulast=Tikhonova&rft.aufirst=Irina&rft.date=2008-02-14&rft.volume=51&rft.issue=3&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm7012425 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-05 N1 - Date created - 2008-02-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 2005 Aug 25;48(17):5448-65 [16107144] Cell Metab. 2005 Apr;1(4):245-58 [16054069] J Chem Inf Model. 2005 Jan-Feb;45(1):177-82 [15667143] J Med Chem. 2004 Oct 21;47(22):5381-92 [15481976] J Mol Graph Model. 2000 Aug-Oct;18(4-5):438-51, 538 [11143561] Nature. 2003 Mar 13;422(6928):173-6 [12629551] J Med Chem. 2003 Oct 9;46(21):4377-92 [14521403] Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11304-9 [15277683] J Biol Chem. 2007 Oct 5;282(40):29248-55 [17699519] J Med Chem. 2007 Jun 28;50(13):2981-9 [17552505] J Med Chem. 2007 Jun 14;50(12):2807-17 [17500511] Expert Opin Ther Targets. 2007 May;11(5):661-71 [17465724] J Med Chem. 2007 Mar 22;50(6):1294-303 [17311371] J Med Chem. 2006 Oct 19;49(21):6177-96 [17034125] J Biol Chem. 2006 Sep 15;281(37):27613-20 [16837468] Br J Pharmacol. 2006 Jul;148(5):619-28 [16702987] Bioorg Med Chem Lett. 2006 Apr 1;16(7):1840-5 [16439116] J Biol Chem. 2006 May 12;281(19):13103-9 [16551618] J Med Chem. 2006 Jun 1;49(11):3116-35 [16722631] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm7012425 ER - TY - JOUR T1 - Persistent Na+ and K+-dominated leak currents contribute to respiratory rhythm generation in the pre-Bötzinger complex in vitro. AN - 70294011; 18272697 AB - A central problem in analyzing neural circuit function is establishing how intrinsic neuronal conductances contribute to the generation of network activity. We used real-time calcium activity imaging combined with whole-cell patch-clamp recording to analyze contributions of subthreshold conductances in the excitatory rhythm-generating network in the respiratory pre-Bötzinger complex (pre-BötC) of neonatal rat in vitro brainstem slice preparations. Voltage-clamp ramp recordings from imaged pre-BötC neurons revealed that persistent sodium (NaP) and K+-dominated leak currents primarily contribute to subthreshold I-V relations. We quantified NaP and leak conductance densities (g/C(m)) in intrinsic oscillatory bursters and intrinsically nonbursters, the two main electrophysiological phenotypes of inspiratory neurons within the pre-BötC. Densities of g(NaP) were significantly higher for intrinsic bursters, whereas leak conductance densities were not significantly different between intrinsic bursters and nonbursters. By pharmacologically manipulating g(NaP) and/or g(Leak) directly within the pre-BötC, we could modulate network oscillation frequency over a wide dynamic range and cause transitions between oscillatory and quiescent states. These results were consistent with models of the pre-BötC excitatory network consisting of heterogeneous mixtures of intrinsic bursters and nonintrinsic bursters incorporating g(NaP) and g(Leak) with parameter values found experimentally. We propose a paradigm whereby NaP and Leak represent a functional set of subthreshold conductances that endow the pre-BötC with rhythmogenic properties and represent targets for modulatory control of inspiratory rhythm generation. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Koizumi, Hidehiko AU - Smith, Jeffrey C AD - Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/02/13/ PY - 2008 DA - 2008 Feb 13 SP - 1773 EP - 1785 VL - 28 IS - 7 KW - Neurotransmitter Agents KW - 0 KW - Potassium Channels KW - Sodium Channel Blockers KW - Sodium Channels KW - Substance P KW - 33507-63-0 KW - Tetrodotoxin KW - 4368-28-9 KW - Sodium Cyanide KW - O5DDB9Z95G KW - Index Medicus KW - Rats KW - Sodium Cyanide -- pharmacology KW - Animals, Newborn KW - Animals KW - Patch-Clamp Techniques KW - Neurotransmitter Agents -- pharmacology KW - Neurons -- metabolism KW - Medulla Oblongata -- physiology KW - Substance P -- pharmacology KW - Sodium Channel Blockers -- pharmacology KW - Tetrodotoxin -- pharmacology KW - Potassium Channels -- metabolism KW - Nerve Net -- physiology KW - Sodium Channels -- metabolism KW - Periodicity KW - Respiratory Mechanics -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70294011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Persistent+Na%2B+and+K%2B-dominated+leak+currents+contribute+to+respiratory+rhythm+generation+in+the+pre-B%C3%B6tzinger+complex+in+vitro.&rft.au=Koizumi%2C+Hidehiko%3BSmith%2C+Jeffrey+C&rft.aulast=Koizumi&rft.aufirst=Hidehiko&rft.date=2008-02-13&rft.volume=28&rft.issue=7&rft.spage=1773&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.3916-07.2008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2008-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1523/JNEUROSCI.3916-07.2008 ER - TY - CPAPER T1 - The NF-kappaB Proteome and Transcriptome as Biomarkers and Targets for Therapy in Human Head and Neck Squamous Cell Carcinomas. T2 - 2008 Keystone Symposia on NF-kappaB (B6) AN - 40783370; 4787628 JF - 2008 Keystone Symposia on NF-kappaB (B6) AU - Van Waes, Carter Y1 - 2008/02/12/ PY - 2008 DA - 2008 Feb 12 KW - Bioindicators KW - Squamous cell carcinoma KW - NF-B protein KW - Head and neck cancer KW - Biomarkers KW - Tumors KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40783370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+NF-kappaB+%28B6%29&rft.atitle=The+NF-kappaB+Proteome+and+Transcriptome+as+Biomarkers+and+Targets+for+Therapy+in+Human+Head+and+Neck+Squamous+Cell+Carcinomas.&rft.au=Van+Waes%2C+Carter&rft.aulast=Van+Waes&rft.aufirst=Carter&rft.date=2008-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+NF-kappaB+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=90 7&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of NF-kappaB Function in Lymphocytes. T2 - 2008 Keystone Symposia on NF-kappaB (B6) AN - 40782979; 4787613 JF - 2008 Keystone Symposia on NF-kappaB (B6) AU - Sen, Ranjan Y1 - 2008/02/12/ PY - 2008 DA - 2008 Feb 12 KW - Lymphocytes KW - NF-B protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+NF-kappaB+%28B6%29&rft.atitle=Regulation+of+NF-kappaB+Function+in+Lymphocytes.&rft.au=Sen%2C+Ranjan&rft.aulast=Sen&rft.aufirst=Ranjan&rft.date=2008-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+NF-kappaB+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=90 7&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Aberrations that Activate NF-kappaB Constitutively in Lymphoid Malignancies. T2 - 2008 Keystone Symposia on NF-kappaB (B6) AN - 40777869; 4787627 JF - 2008 Keystone Symposia on NF-kappaB (B6) AU - Staudt, Louis M Y1 - 2008/02/12/ PY - 2008 DA - 2008 Feb 12 KW - Malignancy KW - NF-B protein KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+NF-kappaB+%28B6%29&rft.atitle=Genomic+Aberrations+that+Activate+NF-kappaB+Constitutively+in+Lymphoid+Malignancies.&rft.au=Staudt%2C+Louis+M&rft.aulast=Staudt&rft.aufirst=Louis&rft.date=2008-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+NF-kappaB+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=90 7&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of NF-kappaB in Immunologic Contexts. T2 - 2008 Keystone Symposia on NF-kappaB (B6) AN - 40775390; 4787620 JF - 2008 Keystone Symposia on NF-kappaB (B6) AU - Siebenlist, Ulrich K Y1 - 2008/02/12/ PY - 2008 DA - 2008 Feb 12 KW - NF-B protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+NF-kappaB+%28B6%29&rft.atitle=Regulation+of+NF-kappaB+in+Immunologic+Contexts.&rft.au=Siebenlist%2C+Ulrich+K&rft.aulast=Siebenlist&rft.aufirst=Ulrich&rft.date=2008-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+NF-kappaB+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=90 7&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Actin Dynamics Regulate Force Transmission through Focal Adhesions. T2 - 2008 Keystone Symposia on Cell Migration in Invasion and Inflammation (B7) AN - 40772778; 4787529 JF - 2008 Keystone Symposia on Cell Migration in Invasion and Inflammation (B7) AU - Waterman, Clare M Y1 - 2008/02/12/ PY - 2008 DA - 2008 Feb 12 KW - Adhesion KW - Actin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40772778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Cell+Migration+in+Invasion+and+Inflammation+%28B7%29&rft.atitle=Actin+Dynamics+Regulate+Force+Transmission+through+Focal+Adhesions.&rft.au=Waterman%2C+Clare+M&rft.aulast=Waterman&rft.aufirst=Clare&rft.date=2008-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Cell+Migration+in+Invasion+and+Inflammation+%28B7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=83 7&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - La Crosse virus infectivity, pathogenesis, and immunogenicity in mice and monkeys. AN - 70441134; 18267012 AB - La Crosse virus (LACV), family Bunyaviridae, was first identified as a human pathogen in 1960 after its isolation from a 4 year-old girl with fatal encephalitis in La Crosse, Wisconsin. LACV is a major cause of pediatric encephalitis in North America and infects up to 300,000 persons each year of which 70-130 result in severe disease of the central nervous system (CNS). As an initial step in the establishment of useful animal models to support vaccine development, we examined LACV infectivity, pathogenesis, and immunogenicity in both weanling mice and rhesus monkeys. Following intraperitoneal inoculation of mice, LACV replicated in various organs before reaching the CNS where it replicates to high titer causing death from neurological disease. The peripheral site where LACV replicates to highest titer is the nasal turbinates, and, presumably, LACV can enter the CNS via the olfactory neurons from nasal olfactory epithelium. The mouse infectious dose50 and lethal dose50 was similar for LACV administered either intranasally or intraperitoneally. LACV was highly infectious for rhesus monkeys and infected 100% of the animals at 10 PFU. However, the infection was asymptomatic, and the monkeys developed a strong neutralizing antibody response. In mice, LACV likely gains access to the CNS via the blood stream or via olfactory neurons. The ability to efficiently infect mice intranasally raises the possibility that LACV might use this route to infect its natural hosts. Rhesus monkeys are susceptible to LACV infection and develop strong neutralizing antibody responses after inoculation with as little as 10 PFU. Mice and rhesus monkeys are useful animal models for LACV vaccine immunologic testing although the rhesus monkey model is not optimal. JF - Virology journal AU - Bennett, Richard S AU - Cress, Christina M AU - Ward, Jerrold M AU - Firestone, Cai-Yen AU - Murphy, Brian R AU - Whitehead, Stephen S AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. bennettri@niaid.nih.gov Y1 - 2008/02/11/ PY - 2008 DA - 2008 Feb 11 SP - 25 VL - 5 KW - Antibodies, Viral KW - 0 KW - Antigens, Viral KW - Index Medicus KW - Virus Replication KW - Animals KW - Humans KW - Mice KW - Antibodies, Viral -- immunology KW - Central Nervous System -- virology KW - Antigens, Viral -- immunology KW - Cercopithecus aethiops KW - Neutralization Tests KW - Lethal Dose 50 KW - Central Nervous System -- pathology KW - Vero Cells KW - Macaca mulatta KW - Nose -- virology KW - Peritoneum -- virology KW - Cell Line KW - Female KW - La Crosse virus -- immunology KW - La Crosse virus -- physiology KW - Disease Models, Animal KW - La Crosse virus -- pathogenicity KW - Encephalitis, California -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70441134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology+journal&rft.atitle=La+Crosse+virus+infectivity%2C+pathogenesis%2C+and+immunogenicity+in+mice+and+monkeys.&rft.au=Bennett%2C+Richard+S%3BCress%2C+Christina+M%3BWard%2C+Jerrold+M%3BFirestone%2C+Cai-Yen%3BMurphy%2C+Brian+R%3BWhitehead%2C+Stephen+S&rft.aulast=Bennett&rft.aufirst=Richard&rft.date=2008-02-11&rft.volume=5&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Virology+journal&rft.issn=1743-422X&rft_id=info:doi/10.1186%2F1743-422X-5-25 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-22 N1 - Date created - 2008-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Trop Med Hyg. 1975 Nov;24(6 Pt 1):999-1005 [1106233] J Virol. 1976 Dec;20(3):664-75 [994302] Am J Trop Med Hyg. 1977 Jul;26(4):815-21 [889022] Virology. 1980 Apr 15;102(1):190-204 [7368566] Am J Trop Med Hyg. 1981 May;30(3):706-14 [7258486] Prog Clin Biol Res. 1983;123:139-44 [6346336] Prog Clin Biol Res. 1983;123:179-86 [6867033] Lab Invest. 1984 Apr;50(4):447-55 [6708454] Am J Trop Med Hyg. 1985 May;34(3):586-95 [4003669] Neuropathol Appl Neurobiol. 1987 Mar-Apr;13(2):111-22 [3039392] Virology. 1989 Jun;170(2):556-60 [2543129] Arch Virol. 1989;108(1-2):89-99 [2512895] Virology. 1991 Jul;183(1):320-30 [2053286] J Virol. 1992 Feb;66(2):992-8 [1731117] J Virol. 1993 Jul;67(7):3861-7 [8510208] J Infect Dis. 1993 Aug;168(2):358-60 [8335971] Annu Rev Microbiol. 1993;47:117-38 [8257095] Clin Microbiol Rev. 1994 Jan;7(1):89-116 [8118792] Brain Res. 1994 Jan 28;635(1-2):81-95 [8173982] Virology. 1994 Nov 1;204(2):616-25 [7941329] Virology. 1995 May 10;209(1):257-62 [7747478] Pediatrics. 1997 Feb;99(2):261-7 [9024460] Virus Res. 1997 May;48(2):143-8 [9175252] J Clin Microbiol. 1998 Nov;36(11):3332-6 [9774588] J Child Neurol. 1999 Jan;14(1):1-14 [10025535] Clin Infect Dis. 1999 Jan;28(1):93-7 [10028077] Hum Gene Ther. 1999 Jul 1;10(10):1649-58 [10428210] Am J Trop Med Hyg. 1999 Mar;60(3):430-8 [10466972] Am J Epidemiol. 1965 Mar;81:245-53 [14261030] J Virol. 2007 May;81(10):4991-9 [17344298] Virol J. 2007;4:41 [17488515] Antiviral Res. 2008 Apr;78(1):79-90 [18036672] J Med Entomol. 2000 Jul;37(4):559-70 [10916297] Clin Infect Dis. 2000 Oct;31(4):1113-4 [11049801] N Engl J Med. 2001 Mar 15;344(11):801-7 [11248155] Pediatr Neurol. 2001 Nov;25(5):413-5 [11744319] Emerg Infect Dis. 2001 Sep-Oct;7(5):807-11 [11747692] Am J Trop Med Hyg. 2003 Nov;69(5):509-18 [14695088] Pediatrics. 1973 Nov;52(5):680-91 [4355363] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1743-422X-5-25 ER - TY - JOUR T1 - Neonatal clomipramine induced endogenous depression in rats is associated with learning impairment in adulthood. AN - 70092220; 17889946 AB - Clinical studies show cognitive impairment in depression. However, the neural substrates underlying these remain elusive. Hence, we have examined the effect of neonatal clomipramine treatment on cognition in adulthood. The neonatal clomipramine treated rats displayed a profound impairment in partially baited 8-arm radial maze task. This work provides a novel perspective into neural basis of depression associated cognitive changes and help in development of therapeutic strategies to treat depression related memory dysfunctions. JF - Behavioural brain research AU - Bhagya, V AU - Srikumar, B N AU - Raju, T R AU - Shankaranarayana Rao, B S AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, PB #2900, Hosur Road, Bangalore 560029, India. Y1 - 2008/02/11/ PY - 2008 DA - 2008 Feb 11 SP - 190 EP - 194 VL - 187 IS - 1 SN - 0166-4328, 0166-4328 KW - Antidepressive Agents, Tricyclic KW - 0 KW - Clomipramine KW - NUV44L116D KW - Index Medicus KW - Rats KW - Animals KW - Psychomotor Performance -- drug effects KW - Memory -- drug effects KW - Rats, Wistar KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Memory, Short-Term -- drug effects KW - Female KW - Antidepressive Agents, Tricyclic -- pharmacology KW - Depressive Disorder -- psychology KW - Depressive Disorder -- chemically induced KW - Learning Disorders -- psychology KW - Clomipramine -- pharmacology KW - Animals, Newborn -- physiology KW - Learning Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70092220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Neonatal+clomipramine+induced+endogenous+depression+in+rats+is+associated+with+learning+impairment+in+adulthood.&rft.au=Bhagya%2C+V%3BSrikumar%2C+B+N%3BRaju%2C+T+R%3BShankaranarayana+Rao%2C+B+S&rft.aulast=Bhagya&rft.aufirst=V&rft.date=2008-02-11&rft.volume=187&rft.issue=1&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=01664328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Molecular Mechanism of Asymmetric DNA Transposition. T2 - 2008 Keystone Symposia on DNA Replication and Recombination (B5) AN - 40771599; 4787425 JF - 2008 Keystone Symposia on DNA Replication and Recombination (B5) AU - Dyda, Fred Y1 - 2008/02/10/ PY - 2008 DA - 2008 Feb 10 KW - Transposition KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geoforum&rft.atitle=Towards+%27hybrid+accountability%27+in+EU+biofuels+policy%3F+Community+grievances+and+competing+water+claims+in+the+Central+Kalimantan+oil+palm+sector&rft.au=Larsen%2C+Rasmus+Klocker%3BJiwan%2C+Norman%3BRompas%2C+Arie%3BJenito%2C+Johanes%3BOsbeck%2C+Maria%3BTarigan%2C+Abetnego&rft.aulast=Larsen&rft.aufirst=Rasmus&rft.date=2014-07-01&rft.volume=54&rft.issue=&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Geoforum&rft.issn=00167185&rft_id=info:doi/10.1016%2Fj.geoforum.2013.09.010 L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interplay of E. coli Polymerases during Genome Duplication. T2 - 2008 Keystone Symposia on DNA Replication and Recombination (B5) AN - 40770095; 4787427 JF - 2008 Keystone Symposia on DNA Replication and Recombination (B5) AU - Curti, Elena Y1 - 2008/02/10/ PY - 2008 DA - 2008 Feb 10 KW - Genomes KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40770095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+DNA+Replication+and+Recombination+%28B5%29&rft.atitle=Interplay+of+E.+coli+Polymerases+during+Genome+Duplication.&rft.au=Curti%2C+Elena&rft.aulast=Curti&rft.aufirst=Elena&rft.date=2008-02-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+DNA+Replication+and+Recombination+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Y-Family Polymerases and their Role in the Translesion Synthesis of Alkylation Damage. T2 - 2008 Keystone Symposia on DNA Replication and Recombination (B5) AN - 40768481; 4787445 JF - 2008 Keystone Symposia on DNA Replication and Recombination (B5) AU - Woodgate, Roger Y1 - 2008/02/10/ PY - 2008 DA - 2008 Feb 10 KW - Alkylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+DNA+Replication+and+Recombination+%28B5%29&rft.atitle=Y-Family+Polymerases+and+their+Role+in+the+Translesion+Synthesis+of+Alkylation+Damage.&rft.au=Woodgate%2C+Roger&rft.aulast=Woodgate&rft.aufirst=Roger&rft.date=2008-02-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+DNA+Replication+and+Recombination+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human ELG1 Functions to Repair DNA Damage through its Interaction with PCNA and Polymerase eta. T2 - 2008 Keystone Symposia on DNA Replication and Recombination (B5) AN - 40768070; 4787432 JF - 2008 Keystone Symposia on DNA Replication and Recombination (B5) AU - Sikdar, Nilabja Y1 - 2008/02/10/ PY - 2008 DA - 2008 Feb 10 KW - Proliferating cell nuclear antigen KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Third+World+Quarterly&rft.atitle=Certifying+in+Contested+Spaces%3A+private+regulation+in+Indonesian+forestry+and+palm+oil&rft.au=McCarthy%2C+John+F&rft.aulast=McCarthy&rft.aufirst=John&rft.date=2012-11-01&rft.volume=33&rft.issue=10&rft.spage=1871&rft.isbn=&rft.btitle=&rft.title=Third+World+Quarterly&rft.issn=01436597&rft_id=info:doi/10.1080%2F01436597.2012.729721 L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NCIs Core Genotyping Facility: Circular Science at Work. T2 - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AN - 40788360; 4789307 JF - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AU - Hutchinson, A A Y1 - 2008/02/09/ PY - 2008 DA - 2008 Feb 09 KW - Genotyping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40788360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.atitle=NCIs+Core+Genotyping+Facility%3A+Circular+Science+at+Work.&rft.au=Hutchinson%2C+A+A&rft.aulast=Hutchinson&rft.aufirst=A&rft.date=2008-02-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B07D7989D-B414-4476-9074 -4FD60E6FFD4E%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CPAS-MART, a Biomart Based Query Application for CPAS Proteomics Repository at NCI. T2 - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AN - 40787206; 4789322 JF - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AU - Yang, L AU - Chan, D AU - Bhattaru, R AU - Hu, B. AU - Schaefer, C AU - Rudriguez, H AU - Kinsinger, C Y1 - 2008/02/09/ PY - 2008 DA - 2008 Feb 09 KW - Proteomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40787206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.atitle=CPAS-MART%2C+a+Biomart+Based+Query+Application+for+CPAS+Proteomics+Repository+at+NCI.&rft.au=Yang%2C+L%3BChan%2C+D%3BBhattaru%2C+R%3BHu%2C+B.%3BSchaefer%2C+C%3BRudriguez%2C+H%3BKinsinger%2C+C&rft.aulast=Yang&rft.aufirst=L&rft.date=2008-02-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B07D7989D-B414-4476-9074 -4FD60E6FFD4E%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enrichment and Biochemical Characterization of Low Molecular Weight Polypeptides from Human Blood Plasma and Serum using HPLC, N-terminal Sequencing and Mass Spectrometry. T2 - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AN - 40787065; 4789284 JF - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AU - Chertov, O AU - Zhou, M AU - Veenstra, T AU - Simpson, J AU - Fisher, R Y1 - 2008/02/09/ PY - 2008 DA - 2008 Feb 09 KW - Mass spectroscopy KW - Biochemistry KW - Blood KW - High-performance liquid chromatography KW - Polypeptides KW - Serum KW - Serological studies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40787065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.atitle=Enrichment+and+Biochemical+Characterization+of+Low+Molecular+Weight+Polypeptides+from+Human+Blood+Plasma+and+Serum+using+HPLC%2C+N-terminal+Sequencing+and+Mass+Spectrometry.&rft.au=Chertov%2C+O%3BZhou%2C+M%3BVeenstra%2C+T%3BSimpson%2C+J%3BFisher%2C+R&rft.aulast=Chertov&rft.aufirst=O&rft.date=2008-02-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B07D7989D-B414-4476-9074 -4FD60E6FFD4E%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modification of Virion Internal Proteins withTetraethylthiuram Disulfide to Inactivate Retrovirus Virions While Retaining Native Env Structure. T2 - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AN - 40782221; 4789378 JF - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AU - Chertova, E AU - Roser, J D AU - Bess Jr, J AU - Lifson, J Y1 - 2008/02/09/ PY - 2008 DA - 2008 Feb 09 KW - Virions KW - Retrovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.atitle=Modification+of+Virion+Internal+Proteins+withTetraethylthiuram+Disulfide+to+Inactivate+Retrovirus+Virions+While+Retaining+Native+Env+Structure.&rft.au=Chertova%2C+E%3BRoser%2C+J+D%3BBess+Jr%2C+J%3BLifson%2C+J&rft.aulast=Chertova&rft.aufirst=E&rft.date=2008-02-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B07D7989D-B414-4476-9074 -4FD60E6FFD4E%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Phosphorylation Dependent Protein-Protein Interactions of a-Synuclein. T2 - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AN - 40776395; 4789382 JF - 2008 Meeting of the Association of Biomolecular Resource Facilities (ABRF 2008) AU - McFarland, M A AU - Ellis, C E AU - Nussbaum, R L AU - Markey, S P Y1 - 2008/02/09/ PY - 2008 DA - 2008 Feb 09 KW - Synuclein KW - Protein interaction KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40776395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.atitle=Identification+of+Phosphorylation+Dependent+Protein-Protein+Interactions+of+a-Synuclein.&rft.au=McFarland%2C+M+A%3BEllis%2C+C+E%3BNussbaum%2C+R+L%3BMarkey%2C+S+P&rft.aulast=McFarland&rft.aufirst=M&rft.date=2008-02-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+Association+of+Biomolecular+Resource+Facilities+%28ABRF+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B07D7989D-B414-4476-9074 -4FD60E6FFD4E%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Reactive Oxygen Species Modulate Anopheles gambiae Immunity against Bacteria and Plasmodium AN - 20020019; 8038472 AB - The involvement of reactive oxygen species (ROS) in mosquito immunity against bacteria and Plasmodium was investigated in the malaria vector Anopheles gambiae. Strains of An. gambiae with higher systemic levels of ROS survive a bacterial challenge better, whereas reduction of ROS by dietary administration of antioxidants significantly decreases survival, indicating that ROS are required to mount effective antibacterial responses. Expression of several ROS detoxification enzymes increases in the midgut and fat body after a blood meal. Furthermore, expression of several of these enzymes increases to even higher levels when mosquitoes are fed a Plasmodium berghei-infected meal, indicating that the oxidative stress after a blood meal is exacerbated by Plasmodium infection. Paradoxically, a complete lack of induction of catalase mRNA and lower catalase activity were observed in P. berghei-infected midguts. This suppression of midgut catalase expression is a specific response to ookinete midgut invasion and is expected to lead to higher local levels of hydrogen peroxide. Further reduction of catalase expression by double-stranded RNA-mediated gene silencing promoted parasite clearance by a lytic mechanism and reduced infection significantly. High mosquito mortality is often observed after P. berghei infection. Death appears to result in part from excess production of ROS, as mortality can be decreased by oral administration of uric acid, a strong antioxidant. We conclude that ROS modulate An. gambiae immunity and that the mosquito response to P. berghei involves a local reduction of detoxification of hydrogen peroxide in the midgut that contributes to limit Plasmodium infection through a lytic mechanism. JF - Journal of Biological Chemistry AU - Molina-Cruz, Alvaro AU - DeJong, Randall J AU - Charles, Bradley AU - Gupta, Lalita AU - Kumar, Sanjeev AU - Jaramillo-Gutierrez, Giovanna AU - Barillas-Mury, Carolina AD - Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20892-8130 and Department of Microbiology, Immunology, and Pathology, Colorado State University, Ft. Collins, Colorado 80523 Y1 - 2008/02/08/ PY - 2008 DA - 2008 Feb 08 SP - 3217 EP - 3223 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org] VL - 283 IS - 6 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Detoxification KW - Parasites KW - Human diseases KW - Antioxidants KW - Fat body KW - Survival KW - Antibiotics KW - Malaria KW - Blood meals KW - Hosts KW - Infection KW - Public health KW - Disease transmission KW - Reactive oxygen species KW - Hydrogen peroxide KW - Oxidative stress KW - Midgut KW - Aquatic insects KW - Uric acid KW - Mortality KW - Zygotes KW - Oral administration KW - Enzymes KW - Pest control KW - Immunity KW - Anopheles gambiae KW - Catalase KW - mRNA KW - Plasmodium KW - Gene silencing KW - A 01340:Antibiotics & Antimicrobials KW - K 03350:Immunology KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - N 14830:RNA KW - Q1 08485:Species interactions: pests and control KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20020019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Peasant+Studies&rft.atitle=Trajectories+of+land+acquisition+and+enclosure%3A+development+schemes%2C+virtual+land+grabs%2C+and+green+acquisitions+in+Indonesia%27s+Outer+Islands&rft.au=McCarthy%2C+John+F%3BVel%2C+Jacqueline+A.C.%3BAfiff%2C+Suraya&rft.aulast=McCarthy&rft.aufirst=John&rft.date=2012-04-01&rft.volume=39&rft.issue=2&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Peasant+Studies&rft.issn=03066150&rft_id=info:doi/10.1080%2F03066150.2012.671768 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Malaria; Antibiotics; Pest control; Hosts; Aquatic insects; Disease transmission; Public health; Detoxification; Mortality; Antioxidants; Zygotes; Oral administration; Survival; Fat body; Enzymes; Immunity; Blood meals; Infection; Catalase; mRNA; Reactive oxygen species; Oxidative stress; Hydrogen peroxide; Midgut; Gene silencing; Uric acid; Plasmodium; Anopheles gambiae ER - TY - JOUR T1 - Tyrosine Phosphorylation of MyD88 Adapter-like (Mal) Is Critical for Signal Transduction and Blocked in Endotoxin Tolerance AN - 20006626; 8038461 AB - Toll-like receptor 4 (TLR4) recognition of lipopolysaccharide triggers signalosome assembly among TLR4, sorting (e.g. MyD88 adapter-like (Mal)) and signaling (e.g. MyD88) adapters, initiating recruitment and activation of kinases, activation of transcription factors, and production of inflammatory mediators. In this study we examined whether tyrosine phosphorylation of Mal regulates its interactions with TLR4, MyD88, interleukin-1 (IL-1) receptor-associated kinase (IRAK)-2, and tumor necrosis factor receptor-associated factor (TRAF)-6 and is important for signaling. Overexpression of wild-type Mal in human embryonic kidney 293T cells induced its constitutive tyrosine phosphorylation and led to activation of p38, NF- Kappa B, and IL-8 gene expression. Mutagenesis of Tyr-86, Tyr-106, and Tyr-159 residues within the Toll-IL-1 receptor domain impaired Mal tyrosine phosphorylation, interactions with Bruton tyrosine kinase, phosphorylation of p38, and NF- Kappa B activation. Lipopolysaccharide triggered tyrosine phosphorylation of endogenous Mal and initiated Mal-Bruton-tyrosine kinase interactions in 293/TLR4/MD-2 cells and human monocytes that were suppressed in endotoxin-tolerant cells. Compared with wild-type Mal, Y86A-, Y06A-, and Y159A-Mal variants exhibited higher interactions with TLR4 and MyD88, whereas associations with IRAK-2 and TRAF-6 were not affected. Overexpression of Y86A- and Y106A-Mal in 293/TLR4/MD-2 cells exerted dominant-negative effects on TLR4-inducible p38 phosphorylation and NF- Kappa B reporter activation to the extent comparable with P125H-Mal-mediated suppression. In contrast, tyrosine-deficient Mal species did not affect NF- Kappa B activation when signaling was initiated at the post-receptor level by overexpression of MyD88, IRAK-2, or TRAF-6. Thus, tyrosine phosphorylation of Mal is required for adapter signaling, regulates Mal interactions with TLR4 and receptor signaling, and is inhibited in endotoxin tolerance. JF - Journal of Biological Chemistry AU - Piao, Wenji AU - Song, Chang AU - Chen, Haiyan AU - Wahl, Larry M AU - Fitzgerald, Katherine A AU - O'Neill, Luke A AU - Medvedev, Andrei E AD - Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, and School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland Y1 - 2008/02/08/ PY - 2008 DA - 2008 Feb 08 SP - 3109 EP - 3119 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 6 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - signalosomes KW - MyD88 protein KW - Tumor necrosis factor KW - Interleukin 1 KW - Interleukin 8 KW - NF- Kappa B protein KW - Mutagenesis KW - Inflammation KW - Gene expression KW - Phosphorylation KW - Transcription factors KW - Protein-tyrosine kinase KW - Lipopolysaccharides KW - Monocytes KW - TLR4 protein KW - Toll-like receptors KW - Signal transduction KW - A 01490:Miscellaneous KW - N 14835:Protein-Nucleic Acids Association KW - J 02320:Cell Biology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20006626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Tyrosine+Phosphorylation+of+MyD88+Adapter-like+%28Mal%29+Is+Critical+for+Signal+Transduction+and+Blocked+in+Endotoxin+Tolerance&rft.au=Piao%2C+Wenji%3BSong%2C+Chang%3BChen%2C+Haiyan%3BWahl%2C+Larry+M%3BFitzgerald%2C+Katherine+A%3BO%27Neill%2C+Luke+A%3BMedvedev%2C+Andrei+E&rft.aulast=Piao&rft.aufirst=Wenji&rft.date=2008-02-08&rft.volume=283&rft.issue=6&rft.spage=3109&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endotoxins; MyD88 protein; signalosomes; Tumor necrosis factor; Interleukin 1; Interleukin 8; Inflammation; Mutagenesis; NF- Kappa B protein; Gene expression; Phosphorylation; Transcription factors; Protein-tyrosine kinase; Lipopolysaccharides; Monocytes; TLR4 protein; Toll-like receptors; Signal transduction ER - TY - CPAPER T1 - CD4+ CD25+ Foxp3+ Regulatory T Cells Induce Cytokine Deprivation Apoptosis of CD4+ T Cells. T2 - 2008 Keystone Symposia on Cell Death in the Immune System (J7) AN - 40776303; 4787318 JF - 2008 Keystone Symposia on Cell Death in the Immune System (J7) AU - Lenardo, Michael Y1 - 2008/02/07/ PY - 2008 DA - 2008 Feb 07 KW - Lymphocytes T KW - CD4 antigen KW - Cytokines KW - Apoptosis KW - Immunoregulation KW - CD25 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40776303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Cell+Death+in+the+Immune+System+%28J7%29&rft.atitle=CD4%2B+CD25%2B+Foxp3%2B+Regulatory+T+Cells+Induce+Cytokine+Deprivation+Apoptosis+of+CD4%2B+T+Cells.&rft.au=Lenardo%2C+Michael&rft.aulast=Lenardo&rft.aufirst=Michael&rft.date=2008-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Cell+Death+in+the+Immune+System+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=93 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differences in Eye Movements during Spatial Navigation in Virtual Environments. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40791162; 4790270 JF - 36th Annual International Neuropsychological Society Meeting AU - Mueller, S C AU - Jackson, C P AU - Skelton, R Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Navigation KW - Sex KW - Eye KW - Navigation behavior KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40791162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Gender+Differences+in+Eye+Movements+during+Spatial+Navigation+in+Virtual+Environments.&rft.au=Mueller%2C+S+C%3BJackson%2C+C+P%3BSkelton%2C+R&rft.aulast=Mueller&rft.aufirst=S&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cognitive Profiles Predicts Social Symptoms and Impairments in High Functioning Children with Autism Spectrum Disorders. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40789754; 4790385 JF - 36th Annual International Neuropsychological Society Meeting AU - Black, D O AU - Wallace, G L AU - Harrison, B AU - Rosa, A Della AU - Silvers, J AU - Kenworthy, L Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Children KW - Autism KW - Cognitive ability KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40789754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Cognitive+Profiles+Predicts+Social+Symptoms+and+Impairments+in+High+Functioning+Children+with+Autism+Spectrum+Disorders.&rft.au=Black%2C+D+O%3BWallace%2C+G+L%3BHarrison%2C+B%3BRosa%2C+A+Della%3BSilvers%2C+J%3BKenworthy%2C+L&rft.aulast=Black&rft.aufirst=D&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age, Depressive Symptoms, and Longitudinal Cognitive Decline in Older Adults. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40786362; 4789651 JF - 36th Annual International Neuropsychological Society Meeting AU - Dotson, V AU - Resnick, S M AU - Zonderman, A B Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Age KW - Cognitive ability KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40786362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Age%2C+Depressive+Symptoms%2C+and+Longitudinal+Cognitive+Decline+in+Older+Adults.&rft.au=Dotson%2C+V%3BResnick%2C+S+M%3BZonderman%2C+A+B&rft.aulast=Dotson&rft.aufirst=V&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 10 Things I Hate About You:The Neural Response to Social Praise and Criticism in Generalized Social Phobia (GSP). T2 - 36th Annual International Neuropsychological Society Meeting AN - 40777828; 4790035 JF - 36th Annual International Neuropsychological Society Meeting AU - Blair, K AU - Geraci, M AU - Devido, J AU - Mccaffrey, D AU - Vythilingam, M AU - Ng, P. AU - Jones, M AU - Blair, J R AU - Pine, D S Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Anxiety KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=10+Things+I+Hate+About+You%3AThe+Neural+Response+to+Social+Praise+and+Criticism+in+Generalized+Social+Phobia+%28GSP%29.&rft.au=Blair%2C+K%3BGeraci%2C+M%3BDevido%2C+J%3BMccaffrey%2C+D%3BVythilingam%2C+M%3BNg%2C+P.%3BJones%2C+M%3BBlair%2C+J+R%3BPine%2C+D+S&rft.aulast=Blair&rft.aufirst=K&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Saccadic Incentive Task Reveals differences in Cognitive Control as a Function of Medication Status in Pediatric Bipolar Disorder. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40777427; 4790079 JF - 36th Annual International Neuropsychological Society Meeting AU - Mueller, S C AU - Pine, D S AU - Leibenluft, E AU - Ernst, M Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Pediatrics KW - Bipolar disorder KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Saccadic+Incentive+Task+Reveals+differences+in+Cognitive+Control+as+a+Function+of+Medication+Status+in+Pediatric+Bipolar+Disorder.&rft.au=Mueller%2C+S+C%3BPine%2C+D+S%3BLeibenluft%2C+E%3BErnst%2C+M&rft.aulast=Mueller&rft.aufirst=S&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Response to Emotional Expressions in Generalized Social Phobia (GSP) and Generalized Anxiety Disorder (GAD): Evidence for Separate Disorders. T2 - 36th Annual International Neuropsychological Society Meeting AN - 40775412; 4790036 JF - 36th Annual International Neuropsychological Society Meeting AU - Blair, K AU - Shaywitz, J AU - Smith, B W AU - Rhodes, R AU - Geraci, M AU - Jones, M AU - Mccaffrey, D AU - Vythilingam, M AU - Finger, E AU - Mondillo, K AU - Jacobs, M AU - Charney, D S AU - Blair, J R AU - Drevets, W C AU - Pine, D S Y1 - 2008/02/06/ PY - 2008 DA - 2008 Feb 06 KW - Anxiety KW - Glutamate decarboxylase KW - Emotions KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+International+Neuropsychological+Society+Meeting&rft.atitle=Response+to+Emotional+Expressions+in+Generalized+Social+Phobia+%28GSP%29+and+Generalized+Anxiety+Disorder+%28GAD%29%3A+Evidence+for+Separate+Disorders.&rft.au=Blair%2C+K%3BShaywitz%2C+J%3BSmith%2C+B+W%3BRhodes%2C+R%3BGeraci%2C+M%3BJones%2C+M%3BMccaffrey%2C+D%3BVythilingam%2C+M%3BFinger%2C+E%3BMondillo%2C+K%3BJacobs%2C+M%3BCharney%2C+D+S%3BBlair%2C+J+R%3BDrevets%2C+W+C%3BPine%2C+D+S&rft.aulast=Blair&rft.aufirst=K&rft.date=2008-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+International+Neuropsychological+Society+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.the-ins.org/documents/INS_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages AN - 19998083; 8042258 AB - We report the identification and functional analysis of nine genes from Gram-positive and Gram-negative bacteria and their phages that are similar to lambda ( lambda ) bet or Escherichia coli recT. Beta and RecT are single-strand DNA annealing proteins, referred to here as recombinases. Each of the nine other genes when expressed in E. coli carries out oligonucleotide-mediated recombination. To our knowledge, this is the first study showing single-strand recombinase activity from diverse bacteria. Similar to bet and recT, most of these other recombinases were found to be associated with putative exonuclease genes. Beta and RecT in conjunction with their cognate exonucleases carry out recombination of linear double-strand DNA. Among four of these foreign recombinase/exonuclease pairs tested for recombination with double-strand DNA, three had activity, albeit barely detectable. Thus, although these recombinases can function in E. coli to catalyze oligonucleotide recombination, the double-strand DNA recombination activities with their exonuclease partners were inefficient. This study also demonstrated that Gam, by inhibiting host RecBCD nuclease activity, helps to improve the efficiency of lambda Red-mediated recombination with linear double-strand DNA, but Gam is not absolutely essential. Thus, in other bacterial species where Gam analogs have not been identified, double-strand DNA recombination may still work in the absence of a Gam-like function. We anticipate that at least some of the recombineering systems studied here will potentiate oligonucleotide and double-strand DNA-mediated recombineering in their native or related bacteria. JF - Proceedings of the National Academy of Sciences, USA AU - Datta, Simanti AU - Costantino, Nina AU - Zhou, Xiaomei AU - Court, Donald L AD - Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702 Y1 - 2008/02/05/ PY - 2008 DA - 2008 Feb 05 SP - 1626 EP - 1631 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 5 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Phages KW - Recombination KW - recombinase KW - Gram-negative bacteria KW - Gram-positive bacteria KW - Escherichia coli KW - exonuclease KW - Nuclease KW - Oligonucleotides KW - A 01490:Miscellaneous KW - J 02430:Symbiosis, Antibiosis & Phages KW - V 22310:Genetics, Taxonomy & Structure KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19998083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Third+World+Quarterly&rft.atitle=The+Changing+North-South+and+South-South+Political+Economy+of+Biofuels&rft.au=Dauvergne%2C+Peter%3BNeville%2C+Kate+J&rft.aulast=Dauvergne&rft.aufirst=Peter&rft.date=2009-09-01&rft.volume=30&rft.issue=6&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=Third+World+Quarterly&rft.issn=01436597&rft_id=info:doi/10.1080%2F01436590903037341 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phages; Recombination; Gram-positive bacteria; Gram-negative bacteria; recombinase; Nuclease; exonuclease; Oligonucleotides; Escherichia coli ER - TY - JOUR T1 - Establishment and characterization of OS 99-1, a cell line derived from a highly aggressive primary human osteosarcoma AN - 19344356; 8705460 AB - Osteosarcoma is the most common form of primary bone cancer. In this study, we established a human osteosarcoma cell line (OS 99-1) from a highly aggressive primary tumor. G-banding karyotype analysis demonstrated a large number of clonal abnormalities, as well as extensive intercellular heterogeneity. Through the use of immunologic, molecular, and biochemical analyses, we characterized protein and gene expression profiles confirming the osteogenic nature of the cells. Further evaluation indicated that OS 99-1 cells maintain the capacity to differentiate in an in vitro mineralization assay as well as form tumors in the in vivo chicken embryo model. This cell line provides a useful tool to investigate the molecular mechanisms contributing to osteosarcoma and may have the potential to serve as a culture system for studies involving bone physiology. JF - In Vitro Cellular & Developmental Biology - Animal AU - Gillette, Jennifer M AU - Gibbs, CParker AU - Nielsen-Preiss, Sheila M AU - Sato, JDenry AD - NICHD, Cell Biology and Metabolism Branch, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2008/02/05/ PY - 2008 DA - 2008 Feb 05 SP - 87 EP - 95 PB - Allen Press, Inc., 810 East Tenth St. VL - 44 IS - 3 SN - 1071-2690, 1071-2690 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Osteosarcoma KW - Osteoblast KW - Mineralization KW - Cell line KW - Tumorigenicity KW - Gene expression KW - Molecular modelling KW - Bone cancer KW - Osteosarcoma cells KW - Biochemical analysis KW - Embryos KW - Tumors KW - Karyotypes KW - W 30925:Genetic Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19344356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=Establishment+and+characterization+of+OS+99-1%2C+a+cell+line+derived+from+a+highly+aggressive+primary+human+osteosarcoma&rft.au=Gillette%2C+Jennifer+M%3BGibbs%2C+CParker%3BNielsen-Preiss%2C+Sheila+M%3BSato%2C+JDenry&rft.aulast=Gillette&rft.aufirst=Jennifer&rft.date=2008-02-05&rft.volume=44&rft.issue=3&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1007%2Fs11626-007-9075-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Bone cancer; Molecular modelling; Osteosarcoma cells; Biochemical analysis; Osteosarcoma; Embryos; Tumors; Mineralization; Karyotypes DO - http://dx.doi.org/10.1007/s11626-007-9075-8 ER - TY - CPAPER T1 - Orally Active TNF-Alpha Synthesis Inhibitors: A Role in the Treatment of Neurodegeneration? T2 - 1st International Conference on Drug Design and Discovery (ICDDD 2008) AN - 40782065; 4784874 JF - 1st International Conference on Drug Design and Discovery (ICDDD 2008) AU - Tweedie, D AU - Luo, W AU - Holloway, H W AU - Utsuki, T AU - Lahiri, D K AU - Greig, N H Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - Tumor necrosis factor-a KW - Neurodegeneration KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=1st+International+Conference+on+Drug+Design+and+Discovery+%28ICDDD+2008%29&rft.atitle=Orally+Active+TNF-Alpha+Synthesis+Inhibitors%3A+A+Role+in+the+Treatment+of+Neurodegeneration%3F&rft.au=Tweedie%2C+D%3BLuo%2C+W%3BHolloway%2C+H+W%3BUtsuki%2C+T%3BLahiri%2C+D+K%3BGreig%2C+N+H&rft.aulast=Tweedie&rft.aufirst=D&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=1st+International+Conference+on+Drug+Design+and+Discovery+%28ICDDD+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icddd.com/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcription Factor Dynamics and Global Chromatin Structure. T2 - 2008 Keystone Symposia on Regulatory Mechanisms in Eukaryotic Transcription (B4) AN - 40780534; 4787300 JF - 2008 Keystone Symposia on Regulatory Mechanisms in Eukaryotic Transcription (B4) AU - Hager, Gordon L Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - Chromatin KW - Transcription factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40780534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Regulatory+Mechanisms+in+Eukaryotic+Transcription+%28B4%29&rft.atitle=Transcription+Factor+Dynamics+and+Global+Chromatin+Structure.&rft.au=Hager%2C+Gordon+L&rft.aulast=Hager&rft.aufirst=Gordon&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Regulatory+Mechanisms+in+Eukaryotic+Transcription+%28B4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=95 5&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Intravital Visualization of Multi-Cellular Immune Communication in Lymph Nodes and Tissues. T2 - 2008 Keystone Symposia on Lymphocyte Activation and Signaling (B3) AN - 40780219; 4787252 JF - 2008 Keystone Symposia on Lymphocyte Activation and Signaling (B3) AU - Germain, Ronald N Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - Lymph nodes KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40780219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28B3%29&rft.atitle=Dynamic+Intravital+Visualization+of+Multi-Cellular+Immune+Communication+in+Lymph+Nodes+and+Tissues.&rft.au=Germain%2C+Ronald+N&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 0&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anarchin: A Novel Gene Necessary for T Cell Development. T2 - 2008 Keystone Symposia on Lymphocyte Activation and Signaling (B3) AN - 40780195; 4787240 JF - 2008 Keystone Symposia on Lymphocyte Activation and Signaling (B3) AU - Johnson, Andy L Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40780195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28B3%29&rft.atitle=Anarchin%3A+A+Novel+Gene+Necessary+for+T+Cell+Development.&rft.au=Johnson%2C+Andy+L&rft.aulast=Johnson&rft.aufirst=Andy&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 0&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signaling at the T Cell Antigen Receptor. T2 - 2008 Keystone Symposia on Lymphocyte Activation and Signaling (B3) AN - 40779614; 4787246 JF - 2008 Keystone Symposia on Lymphocyte Activation and Signaling (B3) AU - Samelson, Lawrence E Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - T-cell receptor KW - Signal transduction KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40779614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28B3%29&rft.atitle=Signaling+at+the+T+Cell+Antigen+Receptor.&rft.au=Samelson%2C+Lawrence+E&rft.aulast=Samelson&rft.aufirst=Lawrence&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 0&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RNA Polymerase is Poised for Rapid Activation Across the Genome. T2 - 2008 Keystone Symposia on Regulatory Mechanisms in Eukaryotic Transcription (B4) AN - 40779132; 4787282 JF - 2008 Keystone Symposia on Regulatory Mechanisms in Eukaryotic Transcription (B4) AU - Adelman, Karen Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - Genomes KW - DNA-directed RNA polymerase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40779132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Regulatory+Mechanisms+in+Eukaryotic+Transcription+%28B4%29&rft.atitle=RNA+Polymerase+is+Poised+for+Rapid+Activation+Across+the+Genome.&rft.au=Adelman%2C+Karen&rft.aulast=Adelman&rft.aufirst=Karen&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Regulatory+Mechanisms+in+Eukaryotic+Transcription+%28B4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=95 5&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered T Cell Function in Mice Deficient in SAP, a Model for X-Linked Lymphoproliferative Disease. T2 - 2008 Keystone Symposia on Lymphocyte Activation and Signaling (B3) AN - 40776062; 4787255 JF - 2008 Keystone Symposia on Lymphocyte Activation and Signaling (B3) AU - Schwartzberg, Pamela L Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - Mice KW - Immunoproliferative diseases KW - Animal models KW - Lymphocytes T KW - X chromosome KW - SAP protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40776062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28B3%29&rft.atitle=Altered+T+Cell+Function+in+Mice+Deficient+in+SAP%2C+a+Model+for+X-Linked+Lymphoproliferative+Disease.&rft.au=Schwartzberg%2C+Pamela+L&rft.aulast=Schwartzberg&rft.aufirst=Pamela&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Lymphocyte+Activation+and+Signaling+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 0&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - OBQI: Project Overview and Objectives (Science and Medical Perspective). T2 - 2008 Keystone Symposia on Biomarker Discovery, Validation and Applications (B1) AN - 40775057; 4787167 JF - 2008 Keystone Symposia on Biomarker Discovery, Validation and Applications (B1) AU - Kelloff, Gary J Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - Reviews KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Biomarker+Discovery%2C+Validation+and+Applications+%28B1%29&rft.atitle=OBQI%3A+Project+Overview+and+Objectives+%28Science+and+Medical+Perspective%29.&rft.au=Kelloff%2C+Gary+J&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Biomarker+Discovery%2C+Validation+and+Applications+%28B1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=94 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Death by a Thousand Cuts: Suppression of Metastasis by Anti-TGF-beta Antibody Therapy. T2 - 2008 Keystone Symposia on TGF-ss Family in Homeostasis and Disease (B2) AN - 40771315; 4787355 JF - 2008 Keystone Symposia on TGF-ss Family in Homeostasis and Disease (B2) AU - Wakefield, Lalage M Y1 - 2008/02/03/ PY - 2008 DA - 2008 Feb 03 KW - Mortality KW - Immunotherapy KW - Antibodies KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+TGF-ss+Family+in+Homeostasis+and+Disease+%28B2%29&rft.atitle=Death+by+a+Thousand+Cuts%3A+Suppression+of+Metastasis+by+Anti-TGF-beta+Antibody+Therapy.&rft.au=Wakefield%2C+Lalage+M&rft.aulast=Wakefield&rft.aufirst=Lalage&rft.date=2008-02-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+TGF-ss+Family+in+Homeostasis+and+Disease+%28B2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=92 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidant-Induced MKP-1 mRNA Stabilization and Translational Upregulation by RNA-Binding Proteins HUR and NF-90 T2 - 2008 Miami Winter Symposium on Regulatory RNA in Biology and Human Health AN - 40822434; 4808112 JF - 2008 Miami Winter Symposium on Regulatory RNA in Biology and Human Health AU - Kuwano, Yuki AU - Kim, Hyeon Ho AU - Abdelmohsen, Kotb AU - Gorospe, Myriam Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - HuR protein KW - Translation KW - MAP kinase phosphatase KW - RNA-binding protein KW - MRNA KW - Stabilizing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40822434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Miami+Winter+Symposium+on+Regulatory+RNA+in+Biology+and+Human+Health&rft.atitle=Oxidant-Induced+MKP-1+mRNA+Stabilization+and+Translational+Upregulation+by+RNA-Binding+Proteins+HUR+and+NF-90&rft.au=Kuwano%2C+Yuki%3BKim%2C+Hyeon+Ho%3BAbdelmohsen%2C+Kotb%3BGorospe%2C+Myriam&rft.aulast=Kuwano&rft.aufirst=Yuki&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Miami+Winter+Symposium+on+Regulatory+RNA+in+Biology+and+Human+Health&rft.issn=&rft_id=info:doi/ L2 - http://www.med.miami.edu/mnbws/x130.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nuclear Retention of HuR through Phosphorylation by Cdk1 T2 - 2008 Miami Winter Symposium on Regulatory RNA in Biology and Human Health AN - 40822416; 4808111 JF - 2008 Miami Winter Symposium on Regulatory RNA in Biology and Human Health AU - Kim, Hyeon Ho AU - Abdelmohsen, Kotb AU - Lal, Ashish AU - Pullmann, Rudolf AU - Yang, Xiaoling AU - Galban, Stefanie AU - Blethrow, Justin AU - Gorospe, Myriam Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - HuR protein KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40822416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Miami+Winter+Symposium+on+Regulatory+RNA+in+Biology+and+Human+Health&rft.atitle=Nuclear+Retention+of+HuR+through+Phosphorylation+by+Cdk1&rft.au=Kim%2C+Hyeon+Ho%3BAbdelmohsen%2C+Kotb%3BLal%2C+Ashish%3BPullmann%2C+Rudolf%3BYang%2C+Xiaoling%3BGalban%2C+Stefanie%3BBlethrow%2C+Justin%3BGorospe%2C+Myriam&rft.aulast=Kim&rft.aufirst=Hyeon&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Miami+Winter+Symposium+on+Regulatory+RNA+in+Biology+and+Human+Health&rft.issn=&rft_id=info:doi/ L2 - http://www.med.miami.edu/mnbws/x130.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specificity of CIRV p19 for Various miRNA Structures T2 - 2008 Miami Winter Symposium on Regulatory RNA in Biology and Human Health AN - 40822313; 4808114 JF - 2008 Miami Winter Symposium on Regulatory RNA in Biology and Human Health AU - Moore, Terrie AU - Hall, Traci Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - MiRNA KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40822313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Miami+Winter+Symposium+on+Regulatory+RNA+in+Biology+and+Human+Health&rft.atitle=Specificity+of+CIRV+p19+for+Various+miRNA+Structures&rft.au=Moore%2C+Terrie%3BHall%2C+Traci&rft.aulast=Moore&rft.aufirst=Terrie&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Miami+Winter+Symposium+on+Regulatory+RNA+in+Biology+and+Human+Health&rft.issn=&rft_id=info:doi/ L2 - http://www.med.miami.edu/mnbws/x130.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Live Cell Photoactivated Localization Microscopy (PALM) for the Spatio-temporal Mapping of Single Molecule Diffusion in the Plasma Membrane T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40744176; 4767145 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Manley, Suliana AU - Gillette, Jennifer M AU - Patterson, George AU - Hess, Harald AU - Shroff, Hari AU - Betzig, Eric AU - Lippincott-Schwartz, Jennifer Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Mapping KW - Plasma membranes KW - Diffusion KW - Microscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40744176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Live+Cell+Photoactivated+Localization+Microscopy+%28PALM%29+for+the+Spatio-temporal+Mapping+of+Single+Molecule+Diffusion+in+the+Plasma+Membrane&rft.au=Manley%2C+Suliana%3BGillette%2C+Jennifer+M%3BPatterson%2C+George%3BHess%2C+Harald%3BShroff%2C+Hari%3BBetzig%2C+Eric%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=Manley&rft.aufirst=Suliana&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computational Modeling of the Toxic b-Amyloid (Ab) Ion Channels in the Membrane T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40744153; 4766213 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Jang, Hyunbum AU - Nussinov, Ruth Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Membranes KW - B-Amyloid KW - Ion channels KW - Alzheimer's disease KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40744153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Computational+Modeling+of+the+Toxic+b-Amyloid+%28Ab%29+Ion+Channels+in+the+Membrane&rft.au=Jang%2C+Hyunbum%3BNussinov%2C+Ruth&rft.aulast=Jang&rft.aufirst=Hyunbum&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Release of NO Detected by EPR from the Delocalized Intermediate Formed During the Reaction of Nitrite with DeoxyHb T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40741855; 4767340 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Banegas, Maria T. Salgado AU - Enika, Nagababu AU - Rifkind, Joseph M Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Nitrite KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40741855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=The+Release+of+NO+Detected+by+EPR+from+the+Delocalized+Intermediate+Formed+During+the+Reaction+of+Nitrite+with+DeoxyHb&rft.au=Banegas%2C+Maria+T.+Salgado%3BEnika%2C+Nagababu%3BRifkind%2C+Joseph+M&rft.aulast=Banegas&rft.aufirst=Maria+T.&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abnormal Formation and Remodeling of Fibers Containing Type I Collagen Homotrimers T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40740900; 4766195 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Han, Sejin AU - Makareeva, Elena AU - Kuznetsova, N V AU - DeRidder, A AU - Sutter, M B AU - McBride, D J AU - Pace, J M AU - Schwarze, U AU - Byers, P H AU - Visse, R AU - Nagase, Hideaki AU - Losert, W AU - Leikin, Sergey Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Fibers KW - Collagen (type I) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40740900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Abnormal+Formation+and+Remodeling+of+Fibers+Containing+Type+I+Collagen+Homotrimers&rft.au=Han%2C+Sejin%3BMakareeva%2C+Elena%3BKuznetsova%2C+N+V%3BDeRidder%2C+A%3BSutter%2C+M+B%3BMcBride%2C+D+J%3BPace%2C+J+M%3BSchwarze%2C+U%3BByers%2C+P+H%3BVisse%2C+R%3BNagase%2C+Hideaki%3BLosert%2C+W%3BLeikin%2C+Sergey&rft.aulast=Han&rft.aufirst=Sejin&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Dynamics Simulations of Polyethylene Oxide with the CHARMM Ether Force Field T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40739552; 4767290 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Lee, Hwankyu AU - Venable, Richard M AU - MacKerell Jr, Alexander D AU - Pastor, Richard W Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Ethers KW - Simulation KW - Polyethylene oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40739552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Molecular+Dynamics+Simulations+of+Polyethylene+Oxide+with+the+CHARMM+Ether+Force+Field&rft.au=Lee%2C+Hwankyu%3BVenable%2C+Richard+M%3BMacKerell+Jr%2C+Alexander+D%3BPastor%2C+Richard+W&rft.aulast=Lee&rft.aufirst=Hwankyu&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Anthrax Channels in Planar Lipid Bilayers by Cyclodextrin Derivatives: A Single Channel Study T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40738793; 4767156 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Nestorovich, Ekaterina M AU - Karginov, Vladimir A AU - Rossovsky, Anna AU - Bezrukov, Sergey M Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Anthrax KW - Lipid bilayers KW - Cyclodextrin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40738793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Inhibition+of+Anthrax+Channels+in+Planar+Lipid+Bilayers+by+Cyclodextrin+Derivatives%3A+A+Single+Channel+Study&rft.au=Nestorovich%2C+Ekaterina+M%3BKarginov%2C+Vladimir+A%3BRossovsky%2C+Anna%3BBezrukov%2C+Sergey+M&rft.aulast=Nestorovich&rft.aufirst=Ekaterina&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insights into Interactions between the Voltage-gated Ca@@u2+@ Channel Beta-subunit, RGK Proteins and Rim3 Protein using FRET T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40738718; 4766331 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Williams, Damian J AU - Puhl III, Henry L AU - Ikeda, Stephen R Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Fluorescence resonance energy transfer KW - Calcium channels (voltage-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40738718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Insights+into+Interactions+between+the+Voltage-gated+Ca%40%40u2%2B%40+Channel+Beta-subunit%2C+RGK+Proteins+and+Rim3+Protein+using+FRET&rft.au=Williams%2C+Damian+J%3BPuhl+III%2C+Henry+L%3BIkeda%2C+Stephen+R&rft.aulast=Williams&rft.aufirst=Damian&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preparation of Labeled Cannabinoid Receptor CB2 for NMR Structural Studies T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40738218; 4767993 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Vukoti, Krishna M AU - Zoubak, Lioudmila AU - Kimura, Tomohiro AU - Gawrisch, Klaus AU - Yeliseev, Alexei Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - N.M.R. KW - Cannabinoid CB2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40738218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Preparation+of+Labeled+Cannabinoid+Receptor+CB2+for+NMR+Structural+Studies&rft.au=Vukoti%2C+Krishna+M%3BZoubak%2C+Lioudmila%3BKimura%2C+Tomohiro%3BGawrisch%2C+Klaus%3BYeliseev%2C+Alexei&rft.aulast=Vukoti&rft.aufirst=Krishna&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Observations of HIV-integrase in Complex with DNA T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40737121; 4768105 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Kotova, Svetlana AU - Li, Min AU - Dimitriadis, Emilios AU - Craigie, Robert Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40737121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Observations+of+HIV-integrase+in+Complex+with+DNA&rft.au=Kotova%2C+Svetlana%3BLi%2C+Min%3BDimitriadis%2C+Emilios%3BCraigie%2C+Robert&rft.aulast=Kotova&rft.aufirst=Svetlana&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time-dependent Inhibition Kinetics of a Bimolecular Association is Highlighted by a Novel Surface Plasmon Resonance Assay T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40735953; 4765080 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - DeSantis, Morgan E AU - Acchione, Mauro AU - Goodman, Brian AU - Lipschultz, Claudia AU - Smith-Gill, Sandra Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Kinetics KW - Surface plasmon resonance KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40735953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Time-dependent+Inhibition+Kinetics+of+a+Bimolecular+Association+is+Highlighted+by+a+Novel+Surface+Plasmon+Resonance+Assay&rft.au=DeSantis%2C+Morgan+E%3BAcchione%2C+Mauro%3BGoodman%2C+Brian%3BLipschultz%2C+Claudia%3BSmith-Gill%2C+Sandra&rft.aulast=DeSantis&rft.aufirst=Morgan&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Obesity-Regulating Peptide BBC1 Interacts with Lipid Membranes in a Surface Charge-Dependent Manner T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40735838; 4768121 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Gurnev, Philip A AU - Harries, Daniel AU - Safrai, Eli AU - Linde, Yaniv AU - Shalev, Deborah AU - Gilon, Chaim AU - Bezrukov, Sergey Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Lipid membranes KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40735838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=The+Obesity-Regulating+Peptide+BBC1+Interacts+with+Lipid+Membranes+in+a+Surface+Charge-Dependent+Manner&rft.au=Gurnev%2C+Philip+A%3BHarries%2C+Daniel%3BSafrai%2C+Eli%3BLinde%2C+Yaniv%3BShalev%2C+Deborah%3BGilon%2C+Chaim%3BBezrukov%2C+Sergey&rft.aulast=Gurnev&rft.aufirst=Philip&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Myosin-Vc is a Low Duty Ratio, Non-Processive Molecular Motor T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40733797; 4768166 DE: JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Takagi, Yasuharu AU - Yang, Yi AU - Fujiwara, Ikuko AU - Jacobs, Damon AU - Cheney, Richard E AU - Kovacs, Mihaly AU - Sellers, James R Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40733797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Human+Myosin-Vc+is+a+Low+Duty+Ratio%2C+Non-Processive+Molecular+Motor&rft.au=Takagi%2C+Yasuharu%3BYang%2C+Yi%3BFujiwara%2C+Ikuko%3BJacobs%2C+Damon%3BCheney%2C+Richard+E%3BKovacs%2C+Mihaly%3BSellers%2C+James+R&rft.aulast=Takagi&rft.aufirst=Yasuharu&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Replacing Nonmuscle Myosin II-B with II-A and Nonmuscle Myosin II-A with II-B Using Homologous Recombination T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40733295; 4768201 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Wang, Aibing AU - Ma, Xuefei AU - Bao, Jianjun AU - Adelstein, Robert S Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Myosin KW - Homologous recombination KW - Recombination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40733295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Replacing+Nonmuscle+Myosin+II-B+with+II-A+and+Nonmuscle+Myosin+II-A+with+II-B+Using+Homologous+Recombination&rft.au=Wang%2C+Aibing%3BMa%2C+Xuefei%3BBao%2C+Jianjun%3BAdelstein%2C+Robert+S&rft.aulast=Wang&rft.aufirst=Aibing&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detecting Transport-related Conformational Changes in the Glutamate Transporter Homologue, Glt@@dPh@ T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40733011; 4765844 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Compton, Emma L.R. AU - Mindell, Joseph A Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Glutamic acid transporter KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40733011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Detecting+Transport-related+Conformational+Changes+in+the+Glutamate+Transporter+Homologue%2C+Glt%40%40dPh%40&rft.au=Compton%2C+Emma+L.R.%3BMindell%2C+Joseph+A&rft.aulast=Compton&rft.aufirst=Emma&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - AFM Visualization and Nanomechanics of Single Clathrin-Mediated Endocytotic Complexes T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40732555; 4767956 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Kotova, Svetlana AU - Prasad, Kondury AU - Smith, Paul D AU - Lafer, Eileen M AU - Nossal, Ralph AU - Jin, Albert J Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Spectroscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40732555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=AFM+Visualization+and+Nanomechanics+of+Single+Clathrin-Mediated+Endocytotic+Complexes&rft.au=Kotova%2C+Svetlana%3BPrasad%2C+Kondury%3BSmith%2C+Paul+D%3BLafer%2C+Eileen+M%3BNossal%2C+Ralph%3BJin%2C+Albert+J&rft.aulast=Kotova&rft.aufirst=Svetlana&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Roles of Fast Motility of Hair Bundles in Avian and Mammalian Ears T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40732292; 4766043 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Sul, Bora AU - Iwasa, Kuni Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Hair KW - Ear KW - Motility KW - Auditory organs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40732292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Roles+of+Fast+Motility+of+Hair+Bundles+in+Avian+and+Mammalian+Ears&rft.au=Sul%2C+Bora%3BIwasa%2C+Kuni&rft.aulast=Sul&rft.aufirst=Bora&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fast-inactivation Mechanism of Kv Channels Revealed by RNA Editing T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40732272; 4767626 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Gonzalez, Carlos L AU - Skrikumar, Deepa AU - Rosenthal, Joshua AU - Holmgren, Miguel Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Potassium channels (voltage-gated) KW - RNA editing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40732272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Fast-inactivation+Mechanism+of+Kv+Channels+Revealed+by+RNA+Editing&rft.au=Gonzalez%2C+Carlos+L%3BSkrikumar%2C+Deepa%3BRosenthal%2C+Joshua%3BHolmgren%2C+Miguel&rft.aulast=Gonzalez&rft.aufirst=Carlos&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bax-Endophilin B1 Oligomers Trigger Membrane Activity T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40731755; 4765799 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Boukari, Hacene AU - Shiu, Brian AU - Banerjee, Soojay AU - Youle, Richard J AU - Bezrukov, Sergey M AU - Rostovtseva, Tatiana K Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Membranes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40731755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Bax-Endophilin+B1+Oligomers+Trigger+Membrane+Activity&rft.au=Boukari%2C+Hacene%3BShiu%2C+Brian%3BBanerjee%2C+Soojay%3BYoule%2C+Richard+J%3BBezrukov%2C+Sergey+M%3BRostovtseva%2C+Tatiana+K&rft.aulast=Boukari&rft.aufirst=Hacene&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibitor Complexed Structures of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter Sphaeroides T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40731604; 4766731 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Xia, Di AU - Esser, Lothar AU - Yu, Chang-An Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Cytochromes KW - Photosynthesis KW - Cytochrome bc1 KW - Inhibitors KW - Rhodobacter sphaeroides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40731604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Inhibitor+Complexed+Structures+of+the+Cytochrome+bc1+from+the+Photosynthetic+Bacterium+Rhodobacter+Sphaeroides&rft.au=Xia%2C+Di%3BEsser%2C+Lothar%3BYu%2C+Chang-An&rft.aulast=Xia&rft.aufirst=Di&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Bilayer Thickness on the Membrane Motor of Outer Hair Cells. T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40730628; 4766521 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Fang, Jie AU - Sinha, Ghanshyam P AU - Iwasa, Kuni H Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Membranes KW - Hair KW - Outer hair cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40730628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Effects+of+Bilayer+Thickness+on+the+Membrane+Motor+of+Outer+Hair+Cells.&rft.au=Fang%2C+Jie%3BSinha%2C+Ghanshyam+P%3BIwasa%2C+Kuni+H&rft.aulast=Fang&rft.aufirst=Jie&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coarse Master Equations for Peptide Folding Dynamics T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40730506; 4766825 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Buchete, Nicolae-Viorel AU - Hummer, Gerhard Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Mathematical models KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40730506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Coarse+Master+Equations+for+Peptide+Folding+Dynamics&rft.au=Buchete%2C+Nicolae-Viorel%3BHummer%2C+Gerhard&rft.aulast=Buchete&rft.aufirst=Nicolae-Viorel&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kelch-Related Protein Krp1 Promotes Lateral Fusion of Myofibril Assembly Intermediates in Cultured Mouse Cardiomyocytes T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40729960; 4767684 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Greenberg, Cynthia C AU - Connelly, Patricia S AU - Daniels, Mathew P AU - Horowits, Robert Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Cardiomyocytes KW - Kelch-related protein KW - Myofibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40729960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Kelch-Related+Protein+Krp1+Promotes+Lateral+Fusion+of+Myofibril+Assembly+Intermediates+in+Cultured+Mouse+Cardiomyocytes&rft.au=Greenberg%2C+Cynthia+C%3BConnelly%2C+Patricia+S%3BDaniels%2C+Mathew+P%3BHorowits%2C+Robert&rft.aulast=Greenberg&rft.aufirst=Cynthia&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Analysis of Nanoparticles Functional Building Blocks and Nanoscale Periodic Patterns T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40729637; 4767859 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Keller, Nicole AU - Mcrae, Ian AU - Cachau, Raul E Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Structural analysis KW - Nanoparticles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40729637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Structural+Analysis+of+Nanoparticles+Functional+Building+Blocks+and+Nanoscale+Periodic+Patterns&rft.au=Keller%2C+Nicole%3BMcrae%2C+Ian%3BCachau%2C+Raul+E&rft.aulast=Keller&rft.aufirst=Nicole&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single-walled Carbon Nanotubes: Interactions and Assembly T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40729550; 4767864 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Podgornik, Rudolf AU - Rajter, Rick F AU - Parsegian, Adrian V AU - French, Roger H AU - Ching, Wai-Yim Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Nanotechnology KW - Carbon KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40729550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Single-walled+Carbon+Nanotubes%3A+Interactions+and+Assembly&rft.au=Podgornik%2C+Rudolf%3BRajter%2C+Rick+F%3BParsegian%2C+Adrian+V%3BFrench%2C+Roger+H%3BChing%2C+Wai-Yim&rft.aulast=Podgornik&rft.aufirst=Rudolf&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correlation of Photoreceptor Membrane Physical Properties with Altered Sterol and Acyl Chain Composition in a Rat Model of Smith-Lemli-Opitz Syndrome T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40729082; 4765274 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Mitchell, Drake C AU - Greeley, Laura AU - Richards, Michael J AU - Fliesler, Steven J Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Membranes KW - Photoreceptors KW - Sterols KW - Physical properties KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40729082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Correlation+of+Photoreceptor+Membrane+Physical+Properties+with+Altered+Sterol+and+Acyl+Chain+Composition+in+a+Rat+Model+of+Smith-Lemli-Opitz+Syndrome&rft.au=Mitchell%2C+Drake+C%3BGreeley%2C+Laura%3BRichards%2C+Michael+J%3BFliesler%2C+Steven+J&rft.aulast=Mitchell&rft.aufirst=Drake&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enthalpy/Entropy Compensation Renders Tension Generation in Muscle Unresponsive to Strain T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40728636; 4766056 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Davis, Julien S AU - Epstein, Neal D Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Muscles KW - Entropy KW - Enthalpy KW - Tension KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40728636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Enthalpy%2FEntropy+Compensation+Renders+Tension+Generation+in+Muscle+Unresponsive+to+Strain&rft.au=Davis%2C+Julien+S%3BEpstein%2C+Neal+D&rft.aulast=Davis&rft.aufirst=Julien&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatially Arranged Nonadhesive Surface Domains for Differentially Controlled Cell Adhesion T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40728232; 4766863 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Krsko, Peter AU - Geller, Herbert M AU - Libera, Matthew R Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Cell adhesion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40728232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Spatially+Arranged+Nonadhesive+Surface+Domains+for+Differentially+Controlled+Cell+Adhesion&rft.au=Krsko%2C+Peter%3BGeller%2C+Herbert+M%3BLibera%2C+Matthew+R&rft.aulast=Krsko&rft.aufirst=Peter&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gated Access to the Pore of P2X Receptor Channels T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40728119; 4766836 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Li, Mufeng AU - Silberberg, Shai D AU - Swartz, Kenton J Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Channel pores KW - Purine P2X receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40728119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Gated+Access+to+the+Pore+of+P2X+Receptor+Channels&rft.au=Li%2C+Mufeng%3BSilberberg%2C+Shai+D%3BSwartz%2C+Kenton+J&rft.aulast=Li&rft.aufirst=Mufeng&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cross-talk between the Three a1C Sites of Modulation of Ca@@dV@1.2 Calcium Channels by Ca@@dV@b@@d2@ Subunits. T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40728075; 4766346 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Kobrinsky, Evgeny AU - Lao, Qi Zong AU - Thomas, Sam AU - Harry, Jo Beth AU - Soldatov, Nikolai M Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Calcium channels KW - Calcium channels (voltage-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40728075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Cross-talk+between+the+Three+a1C+Sites+of+Modulation+of+Ca%40%40dV%401.2+Calcium+Channels+by+Ca%40%40dV%40b%40%40d2%40+Subunits.&rft.au=Kobrinsky%2C+Evgeny%3BLao%2C+Qi+Zong%3BThomas%2C+Sam%3BHarry%2C+Jo+Beth%3BSoldatov%2C+Nikolai+M&rft.aulast=Kobrinsky&rft.aufirst=Evgeny&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin Structure T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40728031; 4767552 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Hinshaw, Jenny Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40728031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Dynamin+Structure&rft.au=Hinshaw%2C+Jenny&rft.aulast=Hinshaw&rft.aufirst=Jenny&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ML-9 Inhibits Store-operated Calcium Entry by Reversing Store Depletion-induced Stim1 Rearrangement T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40727874; 4767053 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Smyth, Jeremy AU - DeHaven, Wayne AU - Bird, Gary AU - Putney, James Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Calcium KW - STIM1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40727874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=ML-9+Inhibits+Store-operated+Calcium+Entry+by+Reversing+Store+Depletion-induced+Stim1+Rearrangement&rft.au=Smyth%2C+Jeremy%3BDeHaven%2C+Wayne%3BBird%2C+Gary%3BPutney%2C+James&rft.aulast=Smyth&rft.aufirst=Jeremy&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Folding/Unfolding Trajectories of Protein G Measured by Single Molecule FRET Spectroscopy. T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40727538; 4767506 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Chung, Hoi Sung AU - Louis, John M AU - Eaton, William A Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Spectroscopy KW - Protein G KW - Protein folding KW - Fluorescence resonance energy transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40727538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Folding%2FUnfolding+Trajectories+of+Protein+G+Measured+by+Single+Molecule+FRET+Spectroscopy.&rft.au=Chung%2C+Hoi+Sung%3BLouis%2C+John+M%3BEaton%2C+William+A&rft.aulast=Chung&rft.aufirst=Hoi&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Salt-Bridges as Molecular Velcro in Elastic Intrinsically Disordered Proteins T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40727401; 4767941 DE: JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Forbes, Jeffrey G AU - Wittebort, Richard AU - Wang, Kuan Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40727401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Salt-Bridges+as+Molecular+Velcro+in+Elastic+Intrinsically+Disordered+Proteins&rft.au=Forbes%2C+Jeffrey+G%3BWittebort%2C+Richard%3BWang%2C+Kuan&rft.aulast=Forbes&rft.aufirst=Jeffrey&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optical Trapping Electrophoresis: Direct Measurement of Electrical and Drag Forces T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40727360; 4767939 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Todd, Brian AU - Cohen, Joel A Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Electrophoresis KW - Trapping KW - Drag KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40727360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Optical+Trapping+Electrophoresis%3A+Direct+Measurement+of+Electrical+and+Drag+Forces&rft.au=Todd%2C+Brian%3BCohen%2C+Joel+A&rft.aulast=Todd&rft.aufirst=Brian&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A New Pathway for Vesicle Fusion and Retrieval at Synapses: Compound Exocytosis is Followed by Bulk Endocytosis T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40727321; 4765330 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - He, Liming AU - Xue, Lei AU - Wu, Ling-Gang Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Exocytosis KW - Endocytosis KW - Vesicle fusion KW - Synapses KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40727321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=A+New+Pathway+for+Vesicle+Fusion+and+Retrieval+at+Synapses%3A+Compound+Exocytosis+is+Followed+by+Bulk+Endocytosis&rft.au=He%2C+Liming%3BXue%2C+Lei%3BWu%2C+Ling-Gang&rft.aulast=He&rft.aufirst=Liming&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible Mechanism of Endosomal Escape of Tat: Membrane Fusion of Intraluminal Vesicles with Late Endosomes T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40726441; 4765206 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Yang, Sung-Tae AU - Chernomordik, Leonid V AU - Melikov, Kamran Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Membrane fusion KW - Endosomes KW - Vesicle fusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40726441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Possible+Mechanism+of+Endosomal+Escape+of+Tat%3A+Membrane+Fusion+of+Intraluminal+Vesicles+with+Late+Endosomes&rft.au=Yang%2C+Sung-Tae%3BChernomordik%2C+Leonid+V%3BMelikov%2C+Kamran&rft.aulast=Yang&rft.aufirst=Sung-Tae&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calmodulin-dependent Gating of Calcium Channels in the Absence of b Subunits T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40726196; 4766712 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Ravindran, Arippa AU - Kobrinsky, Evgeny AU - Lao, Qi Zong AU - Harry, Jo Beth AU - Soldatov, Nikolai M Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Calcium channels KW - Channel gating KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40726196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Calmodulin-dependent+Gating+of+Calcium+Channels+in+the+Absence+of+b+Subunits&rft.au=Ravindran%2C+Arippa%3BKobrinsky%2C+Evgeny%3BLao%2C+Qi+Zong%3BHarry%2C+Jo+Beth%3BSoldatov%2C+Nikolai+M&rft.aulast=Ravindran&rft.aufirst=Arippa&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent Developments Towards a Centralized Repository for Structural Nanobiology Data T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40726186; 4767857 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Cachau, Raul E AU - Gonzalez-Nilo, Fernando D Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40726186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Recent+Developments+Towards+a+Centralized+Repository+for+Structural+Nanobiology+Data&rft.au=Cachau%2C+Raul+E%3BGonzalez-Nilo%2C+Fernando+D&rft.aulast=Cachau&rft.aufirst=Raul&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FCS Studies of c-myc : Endogenous vs. Tranfection-induced Mobility T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40726173; 4767829 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Rosales, Tilman AU - Nie, Zuqin AU - Knutson, Jay R AU - Levens, David Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Mobility KW - C-Myc protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40726173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=FCS+Studies+of+c-myc+%3A+Endogenous+vs.+Tranfection-induced+Mobility&rft.au=Rosales%2C+Tilman%3BNie%2C+Zuqin%3BKnutson%2C+Jay+R%3BLevens%2C+David&rft.aulast=Rosales&rft.aufirst=Tilman&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FRET with Multiple Fluorescent Protein Acceptors T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40726116; 4767833 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Koushik, Srinagesh V AU - Blank, Paul S AU - Vogel, Steven S Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Fluorescence resonance energy transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40726116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=FRET+with+Multiple+Fluorescent+Protein+Acceptors&rft.au=Koushik%2C+Srinagesh+V%3BBlank%2C+Paul+S%3BVogel%2C+Steven+S&rft.aulast=Koushik&rft.aufirst=Srinagesh&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Syncytia Formation Mediated by Viral Fusogens: From Early Fusion Pores to Cell-size Diameter Cytoplasmic Bridges T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725800; 4765195 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Leikina, Evgenia AU - Chen, Andrew AU - Richard, Jean-Philippe AU - Melikov, Kamran AU - Kozlov, Michael M AU - Chernomordik, Leonid V Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Bridges KW - Syncytia KW - Membrane fusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Syncytia+Formation+Mediated+by+Viral+Fusogens%3A+From+Early+Fusion+Pores+to+Cell-size+Diameter+Cytoplasmic+Bridges&rft.au=Leikina%2C+Evgenia%3BChen%2C+Andrew%3BRichard%2C+Jean-Philippe%3BMelikov%2C+Kamran%3BKozlov%2C+Michael+M%3BChernomordik%2C+Leonid+V&rft.aulast=Leikina&rft.aufirst=Evgenia&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Location, Structure, and Dynamics of a Synthetic Cannabinoid Ligand CP 55,940 in Lipid Bilayers: A Solid-state NMR Study. T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725796; 4766558 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Kimura, Tomohiro AU - Cheng, Kejun AU - Rice, Kenner C AU - Gawrisch, Klaus Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - N.M.R. KW - Lipid bilayers KW - Cannabinoids KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Location%2C+Structure%2C+and+Dynamics+of+a+Synthetic+Cannabinoid+Ligand+CP+55%2C940+in+Lipid+Bilayers%3A+A+Solid-state+NMR+Study.&rft.au=Kimura%2C+Tomohiro%3BCheng%2C+Kejun%3BRice%2C+Kenner+C%3BGawrisch%2C+Klaus&rft.aulast=Kimura&rft.aufirst=Tomohiro&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Models of Abeta Channels and Their Blockade by Synthetic Peptides T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725694; 4767138 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Shafrir, Yinon AU - Guy, H R Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Synthetic peptides KW - Models KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Structural+Models+of+Abeta+Channels+and+Their+Blockade+by+Synthetic+Peptides&rft.au=Shafrir%2C+Yinon%3BGuy%2C+H+R&rft.aulast=Shafrir&rft.aufirst=Yinon&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Allosteric Ion Binding Sites in Kainate Receptors. T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725561; 4767500 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Plested, Andrew J AU - Mayer, Mark L Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Glutamic acid receptors KW - Allosteric properties KW - Kainic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Allosteric+Ion+Binding+Sites+in+Kainate+Receptors.&rft.au=Plested%2C+Andrew+J%3BMayer%2C+Mark+L&rft.aulast=Plested&rft.aufirst=Andrew&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tocopherol Reduces Kinetics of Rhodopsin Photoactivation and Thermal Denauration T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725530; 4767477 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Bennett, Michael P AU - Bergman, Christian C AU - Mitchell, Drake C Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Kinetics KW - Photoactivation KW - Rhodopsin KW - Tocopherols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Tocopherol+Reduces+Kinetics+of+Rhodopsin+Photoactivation+and+Thermal+Denauration&rft.au=Bennett%2C+Michael+P%3BBergman%2C+Christian+C%3BMitchell%2C+Drake+C&rft.aulast=Bennett&rft.aufirst=Michael&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gated Access to and Voltage-dependence within the Pore of Cyclic Nucleotide-Gated (CNG) Channels. T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725372; 4766835 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Contreras, Jorge E AU - Chen, Jin AU - Holmgren, Miguel Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Channel pores KW - Ion channels (cyclic nucleotide-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Gated+Access+to+and+Voltage-dependence+within+the+Pore+of+Cyclic+Nucleotide-Gated+%28CNG%29+Channels.&rft.au=Contreras%2C+Jorge+E%3BChen%2C+Jin%3BHolmgren%2C+Miguel&rft.aulast=Contreras&rft.aufirst=Jorge&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Femtosecond Fluorescence Spectra of Human gamma D-, gamma S-Crystallin Trp Mutants: Site-Dependent Ultrafast Quenching T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725275; 4767836 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Xu, Jianhua AU - Chen, Jiejin AU - Toptygin, Dmitri AU - Tcherkasskaya, Olga AU - Callis, Patrik AU - King, Jonathan AU - Brand, Ludwig AU - Knutson, Jay Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Fluorescence KW - Mutants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Femtosecond+Fluorescence+Spectra+of+Human+gamma+D-%2C+gamma+S-Crystallin+Trp+Mutants%3A+Site-Dependent+Ultrafast+Quenching&rft.au=Xu%2C+Jianhua%3BChen%2C+Jiejin%3BToptygin%2C+Dmitri%3BTcherkasskaya%2C+Olga%3BCallis%2C+Patrik%3BKing%2C+Jonathan%3BBrand%2C+Ludwig%3BKnutson%2C+Jay&rft.aulast=Xu&rft.aufirst=Jianhua&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring the Characteristics of a Complex DNA Aptamer using the Fluorescent Pteridine Nucleoside Analog, 6MI, Incorporated at Various Positions in the Sequence T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725171; 4765718 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Hawkins, Mary E AU - Smirnov, Aleksandre AU - Knutson, Jay R AU - Balis, Frank M Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Nucleoside analogs KW - Pteridine KW - Aptamers KW - Nucleotide sequence KW - Analogs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Exploring+the+Characteristics+of+a+Complex+DNA+Aptamer+using+the+Fluorescent+Pteridine+Nucleoside+Analog%2C+6MI%2C+Incorporated+at+Various+Positions+in+the+Sequence&rft.au=Hawkins%2C+Mary+E%3BSmirnov%2C+Aleksandre%3BKnutson%2C+Jay+R%3BBalis%2C+Frank+M&rft.aulast=Hawkins&rft.aufirst=Mary&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Purification of a Novel Tarantula Toxin Targeting the VSD Protein, H@@dv@1 T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40725113; 4765408 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Smith, Jaime J AU - Swartz, Kenton J Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Toxins KW - Protein purification KW - Araneae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Identification+and+Purification+of+a+Novel+Tarantula+Toxin+Targeting+the+VSD+Protein%2C+H%40%40dv%401&rft.au=Smith%2C+Jaime+J%3BSwartz%2C+Kenton+J&rft.aulast=Smith&rft.aufirst=Jaime&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Attractive and Repulsive Protein-Protein Interactions in Highly Concentrated Solution via Measurements of Static Light Scattering T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40724924; 4765144 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Fernandez, Cristina AU - Minton, Allen P Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Light scattering KW - Protein interaction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40724924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Characterization+of+Attractive+and+Repulsive+Protein-Protein+Interactions+in+Highly+Concentrated+Solution+via+Measurements+of+Static+Light+Scattering&rft.au=Fernandez%2C+Cristina%3BMinton%2C+Allen+P&rft.aulast=Fernandez&rft.aufirst=Cristina&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Models of Hexameric Amyloid-beta(1-42) Peptides in Aqueous Solutions and Stability Tests with Discrete Molecular Dynamics Simulations T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40724541; 4767018 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Yun, Sijung AU - Guy, H R Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Simulation KW - Molecular modelling KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40724541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Models+of+Hexameric+Amyloid-beta%281-42%29+Peptides+in+Aqueous+Solutions+and+Stability+Tests+with+Discrete+Molecular+Dynamics+Simulations&rft.au=Yun%2C+Sijung%3BGuy%2C+H+R&rft.aulast=Yun&rft.aufirst=Sijung&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conformational Changes of the ClpA Hexamer. T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40724469; 4765594 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Piszczek, Grzegorz AU - De Donatis, Gian Marco AU - Maurizi, Michael R AU - Ginsburg, Ann Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Hexamers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40724469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Conformational+Changes+of+the+ClpA+Hexamer.&rft.au=Piszczek%2C+Grzegorz%3BDe+Donatis%2C+Gian+Marco%3BMaurizi%2C+Michael+R%3BGinsburg%2C+Ann&rft.aulast=Piszczek&rft.aufirst=Grzegorz&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acid-Sensing Ionic Channels in Rat Anterior Pituitary Cells T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40724448; 4765383 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Kretschmannova, Karla AU - Stojilkovic, Stanko S Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Pituitary (anterior) KW - Pituitary gland KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40724448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Acid-Sensing+Ionic+Channels+in+Rat+Anterior+Pituitary+Cells&rft.au=Kretschmannova%2C+Karla%3BStojilkovic%2C+Stanko+S&rft.aulast=Kretschmannova&rft.aufirst=Karla&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Portability of Paddle Motif Function and Pharmacology in Voltage Sensors T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40724038; 4765411 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Alabi, AbdulRasheed A AU - Bahamonde, Maria Isabel AU - Jung, Hoi Jong AU - Kim, Jae Il AU - Swartz, Kenton J Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Pharmacology KW - Sensors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40724038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Portability+of+Paddle+Motif+Function+and+Pharmacology+in+Voltage+Sensors&rft.au=Alabi%2C+AbdulRasheed+A%3BBahamonde%2C+Maria+Isabel%3BJung%2C+Hoi+Jong%3BKim%2C+Jae+Il%3BSwartz%2C+Kenton+J&rft.aulast=Alabi&rft.aufirst=AbdulRasheed&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Basis of Toxin-paddle Interactions at Protein-lipid Interfaces T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40723629; 4765409 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Milescu, Mirela AU - Alabi, AbdulRasheed A AU - Swartz, Kenton J Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Channels KW - Potassium channels (voltage-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40723629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Molecular+Basis+of+Toxin-paddle+Interactions+at+Protein-lipid+Interfaces&rft.au=Milescu%2C+Mirela%3BAlabi%2C+AbdulRasheed+A%3BSwartz%2C+Kenton+J&rft.aulast=Milescu&rft.aufirst=Mirela&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanometer-scale Rearrangements of Fission Pore During Normal and Aborted Endocytosis T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40722651; 4767008 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Lizunov, Vladimir A AU - Dunina-Barkovskaya, Antonina Ya AU - Kirchhausen, Tom AU - Frolov, Vadim A AU - Zimmerberg, Joshua Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Endocytosis KW - Pores KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40722651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Nanometer-scale+Rearrangements+of+Fission+Pore+During+Normal+and+Aborted+Endocytosis&rft.au=Lizunov%2C+Vladimir+A%3BDunina-Barkovskaya%2C+Antonina+Ya%3BKirchhausen%2C+Tom%3BFrolov%2C+Vadim+A%3BZimmerberg%2C+Joshua&rft.aulast=Lizunov&rft.aufirst=Vladimir&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three States Conformational Change in Membrane Embedded Beta Barrels T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40721266; 4765617 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Tian, Pu Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Membranes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=Three+States+Conformational+Change+in+Membrane+Embedded+Beta+Barrels&rft.au=Tian%2C+Pu&rft.aulast=Tian&rft.aufirst=Pu&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Kinetic Analysis of the DNA Binding and Annealing Activity of the Beta Protein of Phage? T2 - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AN - 40721211; 4765696 JF - Joint 52nd Annual Meeting of the Biophysical Society and 16th International Biophysics Congress AU - Stephen, Andrew G AU - Worthy, Karen M AU - Bindu, Lakshman AU - Fivash, Matthew J AU - Murphy, Kenan C AU - Court, Donald L AU - Fisher, Robert J Y1 - 2008/02/02/ PY - 2008 DA - 2008 Feb 02 KW - Kinetics KW - Phages KW - Beta protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.atitle=A+Kinetic+Analysis+of+the+DNA+Binding+and+Annealing+Activity+of+the+Beta+Protein+of+Phage%3F&rft.au=Stephen%2C+Andrew+G%3BWorthy%2C+Karen+M%3BBindu%2C+Lakshman%3BFivash%2C+Matthew+J%3BMurphy%2C+Kenan+C%3BCourt%2C+Donald+L%3BFisher%2C+Robert+J&rft.aulast=Stephen&rft.aufirst=Andrew&rft.date=2008-02-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+52nd+Annual+Meeting+of+the+Biophysical+Society+and+16th+International+Biophysics+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B 490CC7227CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Focal white matter changes in spasmodic dysphonia: a combined diffusion tensor imaging and neuropathological study AN - 85678503; 200812197 AB - Spasmodic dysphonia is a neurological disorder characterized by involuntary spasms in the laryngeal muscles during speech production. Although the clinical symptoms are well characterized, the pathophysiology of this voice disorder is unknown. We describe here, for the first time to our knowledge, disorder-specific brain abnormalities in these patients as determined by a combined approach of diffusion tensor imaging (DTI) and postmortem histopathology. We used DTI to identify brain changes and to target those brain regions for neuropathological examination. DTI showed right-sided decrease of fractional anisotropy in the genu of the internal capsule and bilateral increase of overall water diffusivity in the white matter along the corticobulbar/ corticospinal tract in 20 spasmodic dysphonia patients compared to 20 healthy subjects. In addition, water diffusivity was bilaterally increased in the lentiform nucleus, ventral thalamus and cerebellar white and grey matter in the patients. These brain changes were substantiated with focal histopathological abnormalities presented as a loss of axonal density and myelin content in the right genu of the internal capsule and clusters of mineral depositions, containing calcium, phosphorus and iron, in the parenchyma and vessel walls of the posterior limb of the internal capsule, putamen, globus pallidus and cerebellum in the postmortem brain tissue from one patient compared to three controls. The specificity of these brain abnormalities is confirmed by their localization, limited only to the corticobulbar/corticospinal tract and its main input/output structures. We also found positive correlation between the diffusivity changes and clinical symptoms of spasmodic dysphonia (r = 0.509, P = 0.037). These brain abnormalities may alter the central control of voluntary voice production and, therefore, may underlie the pathophysiology of this disorder. Adapted from the source document JF - Brain AU - Simonyan, Kristina AU - Tovar-Moll, Fernanda AU - Ostuni, John AU - Hallett, Mark AU - Kalasinsky, Victor F AU - Lewin-Smith, Michael R AU - Rushing, Elisabeth J AU - Vortmeyer, Alexander O AU - Ludlow, Christy L AD - Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Room 5D38, Bethesda, MD 20892-1416, USA simonyak@ninds.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 447 EP - 459 VL - 131 IS - 2 SN - 0006-8950, 0006-8950 KW - Speech Pathology (82650) KW - Dysphonia (20270) KW - Neurolinguistics (57250) KW - Brain (09350) KW - Phonation (64400) KW - Speech Production (82780) KW - Speech Motor Control (82600) KW - Neuroimaging Techniques (57245) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85678503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain&rft.atitle=Focal+white+matter+changes+in+spasmodic+dysphonia%3A+a+combined+diffusion+tensor+imaging+and+neuropathological+study&rft.au=Simonyan%2C+Kristina%3BTovar-Moll%2C+Fernanda%3BOstuni%2C+John%3BHallett%2C+Mark%3BKalasinsky%2C+Victor+F%3BLewin-Smith%2C+Michael+R%3BRushing%2C+Elisabeth+J%3BVortmeyer%2C+Alexander+O%3BLudlow%2C+Christy+L&rft.aulast=Simonyan&rft.aufirst=Kristina&rft.date=2008-02-01&rft.volume=131&rft.issue=2&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Brain&rft.issn=00068950&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRAIAK N1 - SubjectsTermNotLitGenreText - Dysphonia (20270); Speech Production (82780); Brain (09350); Neuroimaging Techniques (57245); Speech Pathology (82650); Neurolinguistics (57250); Speech Motor Control (82600); Phonation (64400) ER - TY - JOUR T1 - Lymph node metastases in malignant tumors of the paranasal sinuses: prognostic value and treatment. AN - 85417363; pmid-18283160 AB - To assess the frequency of nodal involvement and its prognostic value in malignant tumors of the paranasal sinuses, particularly in maxillary sinus squamous cell carcinoma.Retrospective review.Tertiary cancer center.The medical records of 704 consecutive patients surgically treated for malignant tumors of the paranasal sinuses from January 1968 to March 2003 were reviewed. The tumors were staged according to American Joint Committee on Cancer-International Union Against Cancer 2002 classification. Only patients with clinically positive nodes underwent a neck dissection.Lymph node metastases (at presentation or during follow-up, occurring alone, or with concurrent local recurrence and/or distant metastasis). Also analyzed were local recurrence (occurring alone or with concurrent distant metastasis), distant metastasis (occurring alone), and overall survival.The tumor site was the ethmoid sinus in 305 cases and maxillary sinus in 399 cases. At baseline, 5 patients (1.6%) in the ethmoid sinus group and 33 (8.3%) in the maxillary sinus group presented with positive nodes (P < .001); during follow-up, nodal recurrences (alone or simultaneous with T and/or M recurrence) occurred in 15 and 51 patients, respectively, and the corresponding 5-year incidence estimates were 4.3% and 12.5% (P = .001). The highest incidence of node metastases was found in maxillary sinus squamous cell carcinoma, particularly in T2 tumors. Five-year overall survival estimates were 45.3% for patients with N0 tumors and 0% for those with N+ (N1, N2, or N3) ethmoid sinus tumors, and 50.6% and 16.8%, respectively, for patients with maxillary sinus tumors.Lymph node metastases are a poor prognostic factor for patients with malignant tumors of the paranasal sinuses. The incidence of these metastases is low, particularly in ethmoid sinus tumors. A prophylactic treatment of the neck in patients with N0 tumors (surgery or radiotherapy) might be considered in T2 squamous cell carcinoma of the maxillary sinus and in undifferentiated carcinoma of the ethmoid sinus. JF - Archives of otolaryngology--head & neck surgery AU - Cantù, Giulio AU - Bimbi, Gabriella AU - Miceli, Rosalba AU - Mariani, Luigi AU - Colombo, Sarah AU - Riccio, Stefano AU - Squadrelli, Massimo AU - Battisti, Andrea AU - Pompilio, Madia AU - Rossi, Marco AD - National Cancer Institute, Via Venezian 1, 20133 Milano, Italy. giulio.cantu@istitutotumori.mi.it Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 170 EP - 177 VL - 134 IS - 2 SN - 0886-4470, 0886-4470 KW - National Library of Medicine KW - *Adenocarcinoma: mortality KW - *Adenocarcinoma: pathology KW - Aged KW - *Carcinoma, Adenoid Cystic: mortality KW - *Carcinoma, Adenoid Cystic: pathology KW - Carcinoma, Squamous Cell: mortality KW - Carcinoma, Squamous Cell: pathology KW - *Ethmoid Sinus KW - Female KW - Humans KW - Lymphatic Metastasis KW - Male KW - *Maxillary Sinus Neoplasms: mortality KW - *Maxillary Sinus Neoplasms: pathology KW - Middle Aged KW - Neoplasm Recurrence, Local: epidemiology KW - Neoplasm Staging KW - *Paranasal Sinus Neoplasms: mortality KW - *Paranasal Sinus Neoplasms: pathology KW - Prognosis KW - Retrospective Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85417363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+otolaryngology--head+%26+neck+surgery&rft.atitle=Lymph+node+metastases+in+malignant+tumors+of+the+paranasal+sinuses%3A+prognostic+value+and+treatment.&rft.au=Cant%C3%B9%2C+Giulio%3BBimbi%2C+Gabriella%3BMiceli%2C+Rosalba%3BMariani%2C+Luigi%3BColombo%2C+Sarah%3BRiccio%2C+Stefano%3BSquadrelli%2C+Massimo%3BBattisti%2C+Andrea%3BPompilio%2C+Madia%3BRossi%2C+Marco&rft.aulast=Cant%C3%B9&rft.aufirst=Giulio&rft.date=2008-02-01&rft.volume=134&rft.issue=2&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Archives+of+otolaryngology--head+%26+neck+surgery&rft.issn=08864470&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Translating principles of neural plasticity into research on speech motor control recovery and rehabilitation. AN - 85406303; pmid-18230849 AB - To review the principles of neural plasticity and make recommendations for research on the neural bases for rehabilitation of neurogenic speech disorders.A working group in speech motor control and disorders developed this report, which examines the potential relevance of basic research on the brain mechanisms involved in neural plasticity and discusses possible similarities and differences for application to speech motor control disorders. The possible involvement of neural plasticity in changes in speech production in normalcy, development, aging, and neurological diseases and disorders was considered. This report focuses on the appropriate use of functional and structural neuroimaging and the design of feasibility studies aimed at understanding how brain mechanisms are altered by environmental manipulations such as training and stimulation and how these changes might enhance the future development of rehabilitative methods for persons with speech motor control disorders.Increased collaboration with neuroscientists working in clinical research centers addressing human communication disorders might foster research in this area. It is hoped that this article will encourage future research on speech motor control disorders to address the principles of neural plasticity and their application for rehabilitation. JF - Journal of speech, language, and hearing research : JSLHR AU - Ludlow, Christy L AU - Hoit, Jeannette AU - Kent, Raymond AU - Ramig, Lorraine O AU - Shrivastav, Rahul AU - Strand, Edythe AU - Yorkston, Kathryn AU - Sapienza, Christine M AD - National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. ludlowc@ninds.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - S240 EP - S258 VL - 51 IS - 1 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Humans KW - *Neurology: trends KW - *Neuronal Plasticity KW - Recovery of Function KW - *Speech Disorders: physiopathology KW - *Speech Disorders: rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85406303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=Translating+principles+of+neural+plasticity+into+research+on+speech+motor+control+recovery+and+rehabilitation.&rft.au=Ludlow%2C+Christy+L%3BHoit%2C+Jeannette%3BKent%2C+Raymond%3BRamig%2C+Lorraine+O%3BShrivastav%2C+Rahul%3BStrand%2C+Edythe%3BYorkston%2C+Kathryn%3BSapienza%2C+Christine+M&rft.aulast=Ludlow&rft.aufirst=Christy&rft.date=2008-02-01&rft.volume=51&rft.issue=1&rft.spage=S240&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Cites: J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):581-6[17237143]; 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Here, using intravital microscopy we show that after infection of mice with vaccinia virus (a large DNA virus) or vesicular stomatitis virus (a small RNA virus), virions drained to the lymph node and infected cells residing just beneath the subcapsular sinus. Naive CD8 super(+) T cells rapidly migrated to infected cells in the peripheral interfollicular region and then formed tight interactions with dendritic cells, leading to complete T cell activation. Thus, antigen presentation at the lymph node periphery, not at lymphocyte exit sites in deeper lymph node venules, as dogma dictates, has a dominant function in antiviral CD8 super(+) T cell activation. JF - Nature Immunology AU - Hickman, Heather D AU - Takeda, Kazuyo AU - Skon, Cara N AU - Murray, Faith R AU - Hensley, Scott E AU - Loomis, Joshua AU - Barber, Glen N AU - Bennink, Jack R AU - Yewdell, Jonathan W AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 155 EP - 165 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 9 IS - 2 SN - 1529-2908, 1529-2908 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - Virions KW - RNA viruses KW - Sinus KW - CD8 antigen KW - Antigen presentation KW - Infection KW - Lymph nodes KW - Cell activation KW - Dendritic cells KW - Vaccinia virus KW - Microscopy KW - Lymphocytes T KW - Vesicular stomatitis virus KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759319570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Immunology&rft.atitle=Direct+priming+of+antiviral+CD8+super%28%2B%29+T+cells+in+the+peripheral+interfollicular+region+of+lymph+nodes&rft.au=Hickman%2C+Heather+D%3BTakeda%2C+Kazuyo%3BSkon%2C+Cara+N%3BMurray%2C+Faith+R%3BHensley%2C+Scott+E%3BLoomis%2C+Joshua%3BBarber%2C+Glen+N%3BBennink%2C+Jack+R%3BYewdell%2C+Jonathan+W&rft.aulast=Hickman&rft.aufirst=Heather&rft.date=2008-02-01&rft.volume=9&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Nature+Immunology&rft.issn=15292908&rft_id=info:doi/10.1038%2Fni1557 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Virions; Dendritic cells; Microscopy; Lymphocytes T; Sinus; RNA viruses; CD8 antigen; Infection; Antigen presentation; Lymph nodes; Cell activation; Vaccinia virus; Vesicular stomatitis virus DO - http://dx.doi.org/10.1038/ni1557 ER - TY - JOUR T1 - Partial reduction of human FOXP3+ CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration. AN - 70724985; 18481388 AB - The regulation of tolerance to self-proteins and the suppression of T-cell responses have in part been attributed to the activity of CD25+CD4+ T regulatory (Treg) cells. Further, Treg cells can inhibit the antitumor effectiveness of adoptive immunotherapy and active immunization approaches in preclinical models. In an effort to selectively eliminate Treg cells from human peripheral blood mononuclear cell to potentially bolster antitumor responses, we have evaluated the Treg-cell depleting capacity of the CD25-directed immunotoxin, RFT5-SMPT-dgA. In preclinical studies, incubation of human peripheral blood mononuclear cell with RFT5-SMPT-dgA mediated a partial reduction in the levels of CD25+, Foxp3-expressing CD4+ T cells in vitro. Administration of RFT5-SMPT-dgA to 6 patients with metastatic melanoma induced a transient but robust reduction in the number of CD25high CD4 T cells in vivo (a 97.5% mean reduction at nadir; from 69.4 +/- 12.4 cells/miroL to 1.7 +/- 0.3 cells/microL). The reduction in FOXP3+ CD4 T-cell number was less comprehensive (a 71.3% mean reduction at nadir; from 66.6 +/- 16.5 cells/microL to 14.2 +/- 3.9 cells/tL). This resulted in the selective persistence of a stable number of CD25(low/neg) FOXP3+ CD4+ T cells in vivo. No objective antitumor responses were seen in any patient. Our results indicate that the CD25-directed, RFT5-SMPT-dgA immunotoxin can mediate a transient, partial reduction in Treg-cell frequency and number in vitro and in vivo and suggest that comprehensive eradication of human Treg cells in vivo may require the ability to target and eliminate FOXP3+ CD4+ T cells expressing both high and low levels of CD25. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Powell, Daniel J AU - Attia, Peter AU - Ghetie, Victor AU - Schindler, John AU - Vitetta, Ellen S AU - Rosenberg, Steven A AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. poda@mail.med.upenn.edu PY - 2008 SP - 189 EP - 198 VL - 31 IS - 2 SN - 1524-9557, 1524-9557 KW - Antibodies KW - 0 KW - Antibodies, Monoclonal KW - FOXP3 protein, human KW - Forkhead Transcription Factors KW - Immunoconjugates KW - Interleukin-2 Receptor alpha Subunit KW - RFT5-SMPT-dgA immunotoxin KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - CD8-Positive T-Lymphocytes -- drug effects KW - Humans KW - CD4 Lymphocyte Count KW - Melanoma -- immunology KW - Lymphocyte Count KW - T-Lymphocyte Subsets -- drug effects KW - Adult KW - Treatment Outcome KW - Neoplasm Metastasis KW - Leukocytes, Mononuclear -- cytology KW - Male KW - T-Lymphocyte Subsets -- cytology KW - Antibodies -- immunology KW - Cell Count KW - CD8-Positive T-Lymphocytes -- chemistry KW - Immunotherapy -- adverse effects KW - Immunotherapy -- methods KW - CD8-Positive T-Lymphocytes -- cytology KW - Antibodies -- blood KW - Melanoma -- pathology KW - Lymphocyte Depletion -- methods KW - Middle Aged KW - Melanoma -- therapy KW - Leukocytes, Mononuclear -- drug effects KW - T-Lymphocyte Subsets -- chemistry KW - Female KW - T-Lymphocytes, Regulatory -- drug effects KW - Ricin -- administration & dosage KW - Ricin -- therapeutic use KW - Ricin -- immunology KW - T-Lymphocytes, Regulatory -- cytology KW - Interleukin-2 Receptor alpha Subunit -- analysis KW - Interleukin-2 Receptor alpha Subunit -- immunology KW - T-Lymphocytes, Regulatory -- chemistry KW - Forkhead Transcription Factors -- analysis KW - Antibodies, Monoclonal -- administration & dosage KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70724985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Partial+reduction+of+human+FOXP3%2B+CD4+T+cells+in+vivo+after+CD25-directed+recombinant+immunotoxin+administration.&rft.au=Powell%2C+Daniel+J%3BAttia%2C+Peter%3BGhetie%2C+Victor%3BSchindler%2C+John%3BVitetta%2C+Ellen+S%3BRosenberg%2C+Steven+A&rft.aulast=Powell&rft.aufirst=Daniel&rft.date=2008-02-01&rft.volume=31&rft.issue=2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/10.1097%2FCJI.0b013e31815dc0e8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-05-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2005 Jan 1;174(1):90-8 [15611231] J Immunol. 2005 Mar 1;174(5):2591-601 [15728465] Nat Immunol. 2005 Apr;6(4):345-52 [15785760] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] J Immunother. 2005 Jul-Aug;28(4):403-11 [16000960] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] J Immunother. 2005 Nov-Dec;28(6):582-92 [16224276] J Immunol. 2005 Dec 1;175(11):7746-54 [16301685] J Clin Invest. 2005 Dec;115(12):3623-33 [16308572] J Immunother. 2006 Mar-Apr;29(2):208-14 [16531821] Nat Rev Immunol. 2006 Apr;6(4):295-307 [16557261] Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6659-64 [16617117] Cancer Res. 2007 Jan 1;67(1):371-80 [17210720] Am J Transplant. 2007 Jan;7(1):249-55 [17109733] Int J Cancer. 2007 Jun 15;120(12):2723-33 [17315189] J Immunother. 2007 May-Jun;30(4):438-47 [17457218] J Immunol. 2007 Oct 1;179(7):4919-28 [17878392] J Immunol. 1999 Nov 15;163(10):5211-8 [10553041] Leukemia. 2000 Jan;14(1):129-35 [10637488] Nat Genet. 2001 Jan;27(1):20-1 [11137993] J Clin Oncol. 2001 Jan 15;19(2):376-88 [11208829] J Clin Oncol. 2001 Aug 1;19(15):3477-82 [11481353] J Exp Med. 2001 Sep 17;194(6):823-32 [11560997] Clin Lymphoma. 2000 Sep;1(2):110-6; discussion 117 [11707818] J Immunother. 2002 May-Jun;25(3):207-17 [12000862] J Immunol. 2002 Jun 15;168(12):5979-83 [12055202] J Immunother. 2003 Jan-Feb;26(1):85-93 [12514432] Eur J Immunol. 2002 Nov;32(11):3267-75 [12555672] Nat Immunol. 2003 Apr;4(4):330-6 [12612578] Curr Opin Mol Ther. 2003 Feb;5(1):44-51 [12669470] Leuk Lymphoma. 2003 Apr;44(4):731-3 [12769354] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] Immunity. 2004 Jan;20(1):107-18 [14738769] Annu Rev Immunol. 2004;22:531-62 [15032588] J Immunol. 2004 Jul 15;173(2):1444-53 [15240741] Expert Opin Biol Ther. 2004 Jul;4(7):1115-28 [15268678] Biol Blood Marrow Transplant. 2004 Aug;10(8):552-60 [15282533] Nat Med. 2004 Sep;10(9):942-9 [15322536] J Clin Oncol. 2004 Oct 15;22(20):4095-102 [15353540] Am J Pathol. 1987 Mar;126(3):506-12 [3103454] Cancer Res. 1988 Nov 15;48(22):6396-403 [3263186] Proc Natl Acad Sci U S A. 1989 Dec;86(23):9485-8 [2594781] Transplantation. 1990 Jan;49(1):198-201 [2301012] Cancer Res. 1990 Mar 1;50(5):1495-502 [2406013] Eur J Immunol. 1990 Apr;20(4):785-91 [2140788] Cancer Res. 1991 Aug 1;51(15):4052-8 [1855219] Blood. 1994 Jan 15;83(2):466-75 [8286745] Blood. 1997 Jan 15;89(2):403-10 [9002941] Blood. 1998 Jan 15;91(2):399-405 [9427692] Am J Hematol. 1998 May;58(1):87-90 [9590158] Cancer Res. 1999 Jul 1;59(13):3128-33 [10397255] J Immunol. 1999 Aug 1;163(3):1690-5 [10415076] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CJI.0b013e31815dc0e8 ER - TY - JOUR T1 - Prenatal exposure to diethylstilbestrol (DES). AN - 70349259; 18308064 JF - Fertility and sterility AU - Newbold, Retha R AD - Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, North Carolina 27709, USA. newbold1@niehs.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - e55 EP - e56 VL - 89 IS - 2 Suppl KW - Estrogens, Non-Steroidal KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Animals KW - Humans KW - Female KW - Pregnancy KW - Diethylstilbestrol -- adverse effects KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Estrogens, Non-Steroidal -- adverse effects KW - Genital Neoplasms, Female -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70349259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fertility+and+sterility&rft.atitle=Prenatal+exposure+to+diethylstilbestrol+%28DES%29.&rft.au=Newbold%2C+Retha+R&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2008-02-01&rft.volume=89&rft.issue=2+Suppl&rft.spage=e55&rft.isbn=&rft.btitle=&rft.title=Fertility+and+sterility&rft.issn=1556-5653&rft_id=info:doi/10.1016%2Fj.fertnstert.2008.01.062 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-09 N1 - Date created - 2008-02-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fertnstert.2008.01.062 ER - TY - JOUR T1 - Periconception window: advising the pregnancy-planning couple. AN - 70346429; 18308052 AB - To discuss the importance of the periconceptional window with regard to being a critical window of exposure. To review the empirical data related to healthy periconceptional behaviors. Literature review. Human reproduction is a couple-dependent process. Recent literature has highlighted that the periconceptional time period is a critical window of exposure that can impact growth and development. In advising the pregnancy-planning couple, it is of paramount importance that couples have knowledge of the timing of the fertile window to ensure that intercourse occurs on days with the maximum probability of pregnancy. Many women adopt healthier lifestyles while trying to conceive, often quitting smoking, eating healthier or taking vitamins. However, there is a lack of empirical data from prospective studies regarding which environmental exposures or behaviors are or are not safe. Noticeably absent are data regarding the effect of male partners' exposures or behaviors on couple fecundity and fertility. As we improve our ability to pinpoint the timing of conception, we should be able to better advise couples planning pregnancy. JF - Fertility and sterility AU - Louis, Germaine M B AU - Cooney, Maureen A AU - Lynch, Courtney D AU - Handal, Alexis AD - Epidemiology Branch, Division of Epidemiology, Statistics & Prevention Research, National Institute of Child Health & Human Development, Rockville, Maryland 20852, USA. louisg@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - e119 EP - e121 VL - 89 IS - 2 Suppl KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Male KW - Female KW - Pregnancy KW - Environmental Pollutants -- toxicity KW - Pregnancy Complications -- prevention & control KW - Pregnancy Complications -- chemically induced KW - Fertilization -- drug effects KW - Counseling KW - Pregnancy Complications -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70346429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fertility+and+sterility&rft.atitle=Periconception+window%3A+advising+the+pregnancy-planning+couple.&rft.au=Louis%2C+Germaine+M+B%3BCooney%2C+Maureen+A%3BLynch%2C+Courtney+D%3BHandal%2C+Alexis&rft.aulast=Louis&rft.aufirst=Germaine+M&rft.date=2008-02-01&rft.volume=89&rft.issue=2+Suppl&rft.spage=e119&rft.isbn=&rft.btitle=&rft.title=Fertility+and+sterility&rft.issn=1556-5653&rft_id=info:doi/10.1016%2Fj.fertnstert.2007.12.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-09 N1 - Date created - 2008-02-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Fertil Steril. 2002 Nov;78(5):1082-7 [12413998] PLoS Genet. 2007 Jan 12;3(1):e5 [17222059] Ann Epidemiol. 2003 Jul;13(6):412-8 [12875798] J Reprod Immunol. 2003 Aug;59(2):111-35 [12896817] Hum Reprod. 2003 Sep;18(9):1959-66 [12923157] Environ Health Perspect. 2004 Jan;112(1):69-78 [14698934] Environ Health Perspect. 2004 Jan;112(1):79-86 [14698935] Environ Health Perspect. 2004 Feb;112(2):266-71 [14754582] Fertil Steril. 2004 Feb;81(2):384-92 [14967378] JAMA. 1985 May 24-31;253(20):2979-83 [3999259] Br J Ind Med. 1986 Sep;43(9):577-9 [3756106] BMJ. 1993 Feb 20;306(6876):484-7 [8448457] Hum Reprod. 1995 Jul;10(7):1897-906 [8583008] N Engl J Med. 1995 Dec 7;333(23):1517-21 [7477165] Acta Obstet Gynecol Scand. 1996 Apr;75(4):355-9 [8638456] Am J Public Health. 1996 Jun;86(6):844-50 [8659660] Hum Reprod. 1997 Aug;12(8):1750-5 [9308806] Hum Reprod. 1997 Oct;12(10):2324-9 [9402304] Obstet Gynecol. 2000 Nov;96(5 Pt 1):767-71 [11042316] J Clin Endocrinol Metab. 2000 Oct;85(10):3526-30 [11061495] BMJ. 2000 Nov 18;321(7271):1259-62 [11082086] Hum Reprod. 2001 May;16(5):972-8 [11331648] Hum Reprod. 2002 May;17(5):1399-403 [11980771] Int J Epidemiol. 2002 Apr;31(2):285-93 [11980781] Early Hum Dev. 1998 Apr 17;51(1):39-46 [9570030] Reprod Toxicol. 1998 May-Jun;12(3):289-95 [9628552] Hum Reprod. 1998 Jun;13(6):1532-9 [9688387] BMJ. 1998 Aug 22;317(7157):505-10 [9712595] Fertil Steril. 1999 Aug;72(2):240-4 [10438988] Obstet Gynecol. 2005 Apr;105(4):788-93 [15802406] Cancer Causes Control. 2005 Apr;16(3):295-9 [15947881] MMWR Recomm Rep. 2006 Apr 21;55(RR-6):1-23 [16617292] Can J Public Health. 2006 Mar-Apr;97(2):132-5 [16620001] J Obstet Gynecol Neonatal Nurs. 2006 May-Jun;35(3):376-84 [16700687] Matern Child Health J. 2006 Sep;10(5 Suppl):S59-65 [16758331] Matern Child Health J. 2006 Sep;10(5 Suppl):S53-8 [16897374] Fertil Steril. 2003 Mar;79(3):577-84 [12620443] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fertnstert.2007.12.043 ER - TY - JOUR T1 - Current NCI-sponsored Cooperative Group trials of endocrine therapies in breast cancer. AN - 70345855; 18072276 AB - Over several decades, investigators working through National Cancer Institute-sponsored Cooperative Groups have contributed to major advances in the endocrine treatment of breast cancer. Accomplishments include the benefit of tamoxifen therapy for early stage invasive and noninvasive breast cancer, the benefit of raloxifene and tamoxifen for prevention of breast cancer, the improved efficacy of tamoxifen after chemotherapy as opposed to concurrent administration, and the ability of letrozole administered after 5 years of tamoxifen to improve disease-free survival. Most recently, Cooperative Group studies have contributed to the development of a molecular profiling test, Oncotype Dx, which identifies women who have an excellent prognosis with hormonal therapy alone. Ongoing phase 3 clinical trials address the following questions: Is prolonged duration of aromatase inhibitor (AI) therapy beneficial? What is the efficacy and toxicity of steroidal versus nonsteroidal AIs in adjuvant treatment? Is combination hormonal therapy with an estrogen receptor down-regulator (fulvestrant) and an AI superior to an AI alone in the treatment of metastatic breast cancer? Does ovarian suppression offer superior benefit to standard therapy in the treatment of premenopausal breast cancer? What is the role of chemotherapy for early stage breast cancer selected via molecular profiling analysis? How can targeted therapies be used effectively in combination? Studies in subsets of patients defined by molecular profiling will be necessary to fully define breast cancer subtypes and realize the promise of personalized medicine. Close research partnerships that promote large-scale translational research are essential to the continuation of rapid achievements in this field. JF - Cancer AU - Eng-Wong, Jennifer AU - Zujewski, Jo Anne AD - Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA. je95@georgetown.edu Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 723 EP - 729 VL - 112 IS - 3 Suppl SN - 0008-543X, 0008-543X KW - Antineoplastic Agents, Hormonal KW - 0 KW - Receptors, Estrogen KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Receptors, Estrogen -- drug effects KW - Humans KW - National Institutes of Health (U.S.) KW - Female KW - Breast Neoplasms -- drug therapy KW - Clinical Trials as Topic KW - Antineoplastic Agents, Hormonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70345855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Current+NCI-sponsored+Cooperative+Group+trials+of+endocrine+therapies+in+breast+cancer.&rft.au=Eng-Wong%2C+Jennifer%3BZujewski%2C+Jo+Anne&rft.aulast=Eng-Wong&rft.aufirst=Jennifer&rft.date=2008-02-01&rft.volume=112&rft.issue=3+Suppl&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The BRG1 transcriptional coregulator. AN - 70332172; 18301784 AB - The packaging of genomic DNA into chromatin, often viewed as an impediment to the transcription process, plays a fundamental role in the regulation of gene expression. Chromatin remodeling proteins have been shown to alter local chromatin structure and facilitate recruitment of essential factors required for transcription. Brahma-related gene-1 (BRG1), the central catalytic subunit of numerous chromatin-modifying enzymatic complexes, uses the energy derived from ATP-hydrolysis to disrupt the chromatin architecture of target promoters. In this review, we examine BRG1 as a major coregulator of transcription. BRG1 has been implicated in the activation and repression of gene expression through the modulation of chromatin in various tissues and physiological conditions. Outstanding examples are studies demonstrating that BRG1 is a necessary component for nuclear receptor-mediated transcriptional activation. The remodeling protein is also associated with transcriptional corepressor complexes which recruit remodeling activity to target promoters for gene silencing. Taken together, BRG1 appears to be a critical modulator of transcriptional regulation in cellular processes including transcriptional regulation, replication, DNA repair and recombination. JF - Nuclear receptor signaling AU - Trotter, Kevin W AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA. Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 1 VL - 6 KW - Chromatin KW - 0 KW - Multiprotein Complexes KW - Nuclear Proteins KW - Receptors, Cytoplasmic and Nuclear KW - Transcription Factors KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - SMARCA4 protein, human KW - EC 3.6.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Chromatin -- metabolism KW - DNA Repair KW - Multiprotein Complexes -- genetics KW - Humans KW - Multiprotein Complexes -- chemistry KW - Chromatin -- genetics KW - Cell Physiological Phenomena KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Chromatin -- chemistry KW - Adenosine Triphosphate -- metabolism KW - DNA Replication KW - Catalysis KW - Multiprotein Complexes -- metabolism KW - Transcription Factors -- physiology KW - DNA Helicases -- chemistry KW - Promoter Regions, Genetic KW - DNA Helicases -- physiology KW - Transcription Factors -- chemistry KW - Transcriptional Activation -- physiology KW - Nuclear Proteins -- chemistry KW - Nuclear Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70332172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+receptor+signaling&rft.atitle=The+BRG1+transcriptional+coregulator.&rft.au=Trotter%2C+Kevin+W%3BArcher%2C+Trevor+K&rft.aulast=Trotter&rft.aufirst=Kevin&rft.date=2008-02-01&rft.volume=6&rft.issue=&rft.spage=e004&rft.isbn=&rft.btitle=&rft.title=Nuclear+receptor+signaling&rft.issn=1550-7629&rft_id=info:doi/10.1621%2Fnrs.06004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-03 N1 - Date created - 2008-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2000 Dec;20(23):8879-88 [11073988] Mol Cell. 2003 Feb;11(2):377-89 [12620226] Mol Cell Biol. 2003 Jun;23(11):3763-73 [12748280] Cell 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[9843504] Mol Cell. 1999 Feb;3(2):247-53 [10078207] Mol Cell Biol. 1999 Apr;19(4):2724-33 [10082538] Mol Cell Biol. 1999 Jun;19(6):4366-78 [10330177] Cell. 2004 Dec 29;119(7):941-53 [15620353] Biochim Biophys Acta. 2005 Jan 11;1681(2-3):59-73 [15627498] Vitam Horm. 2005;70:281-307 [15727808] Mol Cell Biol. 2005 Mar;25(6):2200-15 [15743818] Mol Cell. 2005 Mar 18;17(6):805-15 [15780937] Proc Natl Acad Sci U S A. 2005 May 24;102(21):7571-6 [15897453] Genes Dev. 2005 Jul 15;19(14):1662-7 [15985610] Biochem Cell Biol. 2005 Aug;83(4):405-17 [16094444] J Biochem. 2005 Oct;138(4):457-65 [16272140] Cancer Res. 2005 Dec 1;65(23):10891-900 [16322236] Mol Endocrinol. 2006 Jan;20(1):1-13 [16002433] EMBO J. 2006 Feb 8;25(3):490-501 [16424906] Chromosome Res. 2006;14(1):83-94 [16506098] J Biol Chem. 2006 Aug 11;281(32):22656-64 [16769725] Oncogene. 2006 Aug 28;25(38):5220-7 [16936740] Biochem J. 2006 Oct 15;399(2):297-304 [16800816] Dev Dyn. 2006 Oct;235(10):2722-35 [16894598] Genes Dev. 2006 Oct 15;20(20):2871-86 [17043312] Biol Chem. 2006 Oct-Nov;387(10-11):1469-78 [17081121] Mol Cell Biol. 2007 Jan;27(1):384-94 [17043109] J Biol Chem. 2006 Dec 22;281(51):38974-80 [17023429] Biochemistry. 2007 Feb 27;46(8):2100-10 [17274598] Mol Cell Endocrinol. 2007 Feb;265-266:162-7 [17240047] Cell. 2007 Feb 23;128(4):651-4 [17320503] Cell. 2007 Feb 23;128(4):693-705 [17320507] J Biol Chem. 2007 Mar 2;282(9):6564-70 [17194702] Biochem Biophys Res Commun. 2007 Apr 13;355(3):661-6 [17320048] Chembiochem. 2007 Jul 23;8(11):1308-16 [17582821] J Mol Biol. 2007 Aug 31;371(5):1135-40 [17603073] Oncogene. 2007 Nov 1;26(50):7153-7 [17486062] EMBO J. 1999 Nov 15;18(22):6385-95 [10562550] Science. 2000 Feb 18;287(5456):1262-5 [10678832] Curr Opin Genet Dev. 2000 Apr;10(2):187-92 [10753786] Cell. 2000 Mar 31;101(1):79-89 [10778858] Cell. 2000 Jul 21;102(2):257-65 [10943845] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1621/nrs.06004 ER - TY - JOUR T1 - Templated mutagenesis in bacteriophage T4 involving imperfect direct or indirect sequence repeats. AN - 70317479; 18245334 AB - Some mutations arise in association with a potential sequence donor that consists of an imperfect direct or reverse repeat. Many such mutations are complex; that is, they consist of multiple close sequence changes. Current models posit that the primer terminus of a replicating DNA molecule dissociates, reanneals with an ectopic template, extends briefly, and then returns to the cognate template, bringing with it a locally different sequence; alternatively, a hairpin structure may form the mutational intermediate when processed by mismatch repair. This process resembles replication repair, in which primer extension is blocked by a lesion in the template; in this case, the ectopic template is the other daughter strand, and the result is error-free bypass of the lesion. We previously showed that mutations that impair replication repair can enhance templated mutagenesis. We show here that the intensity of templated mutation can be exquisitely sensitive to its local sequence, that the donor and recipient arms of an imperfect inverse repeat can exchange roles, and that double mutants carrying two alleles, each affecting both templated mutagenesis and replication repair, can have unexpected phenotypes. We also record an instance in which the mutation rates at two particular sites change concordantly with a distant sequence change, but in a manner that appears unrelated to templated mutagenesis. JF - Genetics AU - Schultz, Gary E AU - Drake, John W AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 661 EP - 673 VL - 178 IS - 2 SN - 0016-6731, 0016-6731 KW - Codon KW - 0 KW - DNA Primers KW - DNA, Viral KW - Index Medicus KW - Base Sequence KW - Codon -- genetics KW - DNA Mutational Analysis KW - Escherichia coli -- genetics KW - DNA, Viral -- genetics KW - DNA Replication KW - Mutagenesis KW - Bacteriophage T4 -- genetics KW - Templates, Genetic KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70317479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Templated+mutagenesis+in+bacteriophage+T4+involving+imperfect+direct+or+indirect+sequence+repeats.&rft.au=Schultz%2C+Gary+E%3BDrake%2C+John+W&rft.aulast=Schultz&rft.aufirst=Gary&rft.date=2008-02-01&rft.volume=178&rft.issue=2&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/10.1534%2Fgenetics.107.083444 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-02 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Mar 30;276(13):10387-97 [11133987] J Biol Chem. 2000 Oct 6;275(40):31496-504 [10906124] J Mol Biol. 2003 Mar 14;327(1):7-18 [12614604] J Biol Chem. 2003 Jul 4;278(27):25247-55 [12697750] J Biol Chem. 2004 Apr 30;279(18):19035-45 [14871889] J Biol Chem. 2004 Aug 20;279(34):35735-40 [15194689] Proc Natl Acad Sci U S A. 1971 Apr;68(4):773-6 [5279518] Mutat Res. 1971 Oct;13(2):109-13 [5138708] Mutat Res. 1976 Jan;34(1):21-34 [1250247] J Mol Biol. 1976 Mar 5;101(3):417-25 [1255724] Mutat Res. 1976 Oct;37(1):91-110 [967189] Genetics. 1976 Nov;84(3):423-36 [1001876] J Mol Biol. 1980 Nov 5;143(3):303-15 [7218357] Proc Natl Acad Sci U S A. 1982 Jul;79(13):4128-32 [7051004] J Mol Biol. 1984 Jun 25;176(2):239-49 [6748077] Genetics. 1985 Apr;109(4):633-59 [3988038] J Mol Biol. 1986 Oct 20;191(4):601-13 [3806675] Genetics. 1987 Mar;115(3):405-17 [3552872] J Mol Biol. 1987 Jun 5;195(3):471-80 [3656422] J Biol Chem. 1988 Oct 15;263(29):14784-9 [3049589] Nature. 1991 Aug 8;352(6335):544-7 [1865910] Genetics. 1991 Aug;128(4):673-85 [1916240] J Biol Chem. 1993 May 15;268(14):10324-34 [7683675] Genetics. 1995 May;140(1):13-25 [7635281] J Mol Biol. 1997 Jun 6;269(2):176-87 [9191063] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8042-6 [9223311] J Mol Biol. 2005 Mar 25;347(2):257-75 [15740739] Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3254-9 [15728347] Biochemistry. 2005 May 31;44(21):7747-56 [15909989] J Mol Biol. 2006 May 12;358(4):963-73 [16574154] Nucleic Acids Res. 2006;34(10):3020-9 [16738140] J Biol Chem. 2006 Sep 8;281(36):26308-19 [16829679] J Biol Chem. 2007 Nov 23;282(47):34401-11 [17823128] J Mol Biol. 2000 Sep 22;302(3):553-64 [10986118] J Mol Biol. 2001 Apr 13;307(5):1195-206 [11292335] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1534/genetics.107.083444 ER - TY - JOUR T1 - Inorganic arsenic and human prostate cancer. AN - 70316763; 18288312 AB - We critically evaluated the etiologic role of inorganic arsenic in human prostate cancer. We assessed data from relevant epidemiologic studies concerning environmental inorganic arsenic exposure. Whole animal studies were evaluated as were in vitro model systems of inorganic arsenic carcinogenesis in the prostate. Multiple studies in humans reveal an association between environmental inorganic arsenic exposure and prostate cancer mortality or incidence. Many of these human studies provide clear evidence of a dose-response relationship. Relevant whole animal models showing a relationship between inorganic arsenic and prostate cancer are not available. However, cellular model systems indicate arsenic can induce malignant transformation of human prostate epithelial cells in vitro. Arsenic also appears to impact prostate cancer cell progression by precipitating events leading to androgen independence in vitro. Available evidence in human populations and human cells in vitro indicates that the prostate is a target for inorganic arsenic carcinogenesis. A role for this common environmental contaminant in human prostate cancer initiation and/or progression would be very important. JF - Environmental health perspectives AU - Benbrahim-Tallaa, Lamia AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NIH/DHHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 158 EP - 164 VL - 116 IS - 2 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - human malignant transformation KW - prostate KW - Ras KW - MAP kinase KW - AR KW - carcinogenesis KW - arsenic KW - DNA methylation KW - androgen-independent KW - Humans KW - Environmental Exposure KW - Male KW - Prostatic Neoplasms -- epidemiology KW - Arsenic -- toxicity KW - Prostatic Neoplasms -- chemically induced KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70316763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Inorganic+arsenic+and+human+prostate+cancer.&rft.au=Benbrahim-Tallaa%2C+Lamia%3BWaalkes%2C+Michael+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=Lamia&rft.date=2008-02-01&rft.volume=116&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10423 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-05 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Environ Health. 1999 May-Jun;54(3):186-93 [10444040] Med Pr. 2004;55(4):313-20 [15620040] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Reprod Biol Endocrinol. 2006;4:9 [16483355] Biochem Soc Trans. 2006 Apr;34(Pt 2):330-3 [16545107] Adv Enzyme Regul. 2006;46:249-79 [16854453] Toxicol Appl Pharmacol. 2006 Oct 1;216(1):69-79 [16806342] Environ Health Perspect. 2007 Feb;115(2):243-7 [17384772] Prostate. 2005 Mar 1;62(4):364-73 [15389782] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Clin Sci (Lond). 2005 Apr;108(4):293-308 [15603554] Toxicol Appl Pharmacol. 2005 May 1;204(3):274-308 [15845419] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Environ Health Perspect. 2005 Sep;113(9):1134-9 [16140617] Chem Res Toxicol. 2006 Jan;19(1):1-15 [16411650] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80 [17306315] J Biol Chem. 2008 Jul 11;283(28):19342-50 [18487201] Mol Pharmacol. 2001 Aug;60(2):302-9 [11455017] Toxicol Appl Pharmacol. 2001 Oct 15;176(2):127-44 [11601889] Nat Rev Cancer. 2001 Oct;1(1):34-45 [11900250] Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6053-8 [11972053] Science. 2002 Jun 21;296(5576):2143-5 [12077387] Am J Pharmacogenomics. 2001;1(4):241-9 [12083956] Carcinogenesis. 2002 Aug;23(8):1387-97 [12151359] Environ Health Perspect. 2002 Oct;110 Suppl 5:767-71 [12426129] Regul Toxicol Pharmacol. 2002 Oct;36(2):162-74 [12460751] J Natl Cancer Inst. 2002 Dec 18;94(24):1888-91 [12488483] Cancer Res. 2003 Apr 15;63(8):1981-9 [12702592] Exp Cell Res. 2003 Nov 1;290(2):234-45 [14567983] Mutat Res. 2003 Dec 10;533(1-2):37-65 [14643412] Chem Res Toxicol. 2003 Dec;16(12):1624-31 [14680377] J Cell Biochem. 2004 Jan 1;91(1):13-25 [14689577] Carcinogenesis. 2004 Jan;25(1):21-8 [14514659] Urology. 2003 Dec 22;62(6 Suppl 1):3-12 [14706503] J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 [15026472] Toxicol Sci. 2004 May;79(1):56-63 [14976345] Cancer Res. 2004 Jun 1;64(11):3871-7 [15172996] J Biol Chem. 2004 Jul 30;279(31):32700-8 [15161912] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):366-76 [15276416] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):394-404 [15276419] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] Hum Exp Toxicol. 2004 Aug;23(8):399-403 [15346721] Cancer Res. 1985 Nov;45(11 Pt 2):5895-9 [4053060] Endocrinology. 1988 Feb;122(2):552-62 [2828003] Lancet. 1988 Feb 20;1(8582):414-5 [2893213] Toxicol Appl Pharmacol. 1989 Sep 15;100(3):398-410 [2551075] Mutat Res. 2000 Apr;462(2-3):219-26 [10767633] J Environ Pathol Toxicol Oncol. 2000;19(3):281-6 [10983894] Arch Toxicol. 2000 Aug;74(6):289-99 [11005674] Cancer Res. 2001 Jan 15;61(2):455-8 [11212230] Chem Res Toxicol. 2001 Apr;14(4):355-61 [11304123] Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61 [11312654] Cancer Res. 2001 May 1;61(9):3550-5 [11325816] Am J Epidemiol. 1989 Dec;130(6):1123-32 [2589305] Cancer Res. 1990 Sep 1;50(17):5470-4 [2386951] Cancer Res. 1990 Nov 1;50(21):6830-2 [2208148] Jpn J Cancer Res. 1991 Dec;82(12):1366-70 [1778759] Br J Cancer. 1994 Jan;69(1):177-82 [7506923] Toxicol Lett. 1995 Dec;82-83:663-72 [8597125] Toxicol Appl Pharmacol. 1996 Feb;136(2):243-9 [8619232] Prostate. 1996 Dec;29(6):386-94 [8977636] Prostate. 1997 Jan 1;30(1):58-64 [9018337] Carcinogenesis. 1997 Jun;18(6):1215-23 [9214605] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10907-12 [9380733] Prostate. 1998 Jun 15;36(1):59-63 [9650918] Eur J Cancer Prev. 1998 Apr;7(2):117-25 [9818773] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] Cancer Res. 1999 Jan 15;59(2):279-84 [9927031] Environ Health Perspect. 1999 May;107(5):359-65 [10210691] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.10423 ER - TY - JOUR T1 - Addition of antipsychotics to medication regimens during schizophrenic inpatient care. AN - 70315770; 18289142 AB - The objective of the present study was to identify schizophrenia inpatients who had their original regimen augmented with additional antipsychotics during acute inpatient care, and to clarify the factors associated with these additions. The subjects were 204 schizophrenia inpatients at 34 acute care hospitals, of whom 42 (20.6%) had further antipsychotics added to their medication regimen during hospitalization. Compared with patients who were not prescribed additional antipsychotics, the subjects were typically discharged with higher dosages of antipsychotics, principally low-potency medications. Patients who exhibited aggressive behavior, who had no physical illness, or whose psychiatrists preferred typical antipsychotics, were more likely to be prescribed additional new antipsychotics. Alternative approaches such as intensive care for aggressive patients and educational intervention with psychiatrists may prove useful in stabilizing patients without adding new antipsychotics unless absolutely necessary, and in simplifying medication regimens. JF - Psychiatry and clinical neurosciences AU - Koyama, Asuka AU - Ito, Hiroto AU - Nakanishi, Miharu AU - Sawamura, Kanae AU - Higuchi, Teruhiko AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. asuka@ncnp.go.jp Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 56 EP - 64 VL - 62 IS - 1 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Acute Disease KW - Aggression -- drug effects KW - Humans KW - Drug Therapy, Combination KW - Patient Education as Topic KW - Psychiatric Status Rating Scales KW - Length of Stay -- statistics & numerical data KW - Risk Factors KW - Adult KW - Middle Aged KW - Female KW - Japan KW - Male KW - Drug Prescriptions -- statistics & numerical data KW - Drug Utilization -- statistics & numerical data KW - Antipsychotic Agents -- administration & dosage KW - Schizophrenia -- diagnosis KW - Patient Admission -- statistics & numerical data KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70315770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+and+clinical+neurosciences&rft.atitle=Addition+of+antipsychotics+to+medication+regimens+during+schizophrenic+inpatient+care.&rft.au=Koyama%2C+Asuka%3BIto%2C+Hiroto%3BNakanishi%2C+Miharu%3BSawamura%2C+Kanae%3BHiguchi%2C+Teruhiko&rft.aulast=Koyama&rft.aufirst=Asuka&rft.date=2008-02-01&rft.volume=62&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Psychiatry+and+clinical+neurosciences&rft.issn=1440-1819&rft_id=info:doi/10.1111%2Fj.1440-1819.2007.01776.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-23 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1819.2007.01776.x ER - TY - JOUR T1 - Self-injury in Japanese junior and senior high-school students: Prevalence and association with substance use. AN - 70313752; 18289152 AB - The present study examined the prevalence of self-injury and its association with substance abuse in 2974 junior and senior high-school students, by self-reporting questionnaires. Consequently, 9.9% of students (boys, 7.5%; girls, 12.1%) reported an experience of self-injury at least once. Significant differences were found in substance use-related problems including alcohol abuse, smoking, and illicit drug use (P < 0.001) between students with and without an experience of self-injury. The results also suggest that self-injuring students may more easily gain access to illicit drugs even if they had not yet experienced the use of illicit drugs. Self-injury in adolescence may be associated with substance use and is considered to be a risk factor predicting future illicit drug use. JF - Psychiatry and clinical neurosciences AU - Matsumoto, Toshihiko AU - Imamura, Fumi AD - Center for Suicide Prevention, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. tmatsu@ncnp.go.jp Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 123 EP - 125 VL - 62 IS - 1 KW - Street Drugs KW - 0 KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Health Surveys KW - Adolescent KW - Male KW - Japan KW - Female KW - Comorbidity KW - Students -- psychology KW - Self-Injurious Behavior -- psychology KW - Substance-Related Disorders -- diagnosis KW - Students -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Self-Injurious Behavior -- epidemiology KW - Smoking -- psychology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Smoking -- epidemiology KW - Self-Injurious Behavior -- diagnosis KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70313752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+and+clinical+neurosciences&rft.atitle=Self-injury+in+Japanese+junior+and+senior+high-school+students%3A+Prevalence+and+association+with+substance+use.&rft.au=Matsumoto%2C+Toshihiko%3BImamura%2C+Fumi&rft.aulast=Matsumoto&rft.aufirst=Toshihiko&rft.date=2008-02-01&rft.volume=62&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Psychiatry+and+clinical+neurosciences&rft.issn=1440-1819&rft_id=info:doi/10.1111%2Fj.1440-1819.2007.01783.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-23 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1819.2007.01783.x ER - TY - JOUR T1 - Safety, tolerability, pharmacokinetics, and efficacy of an interleukin-2 agonist among HIV-infected patients receiving highly active antiretroviral therapy. AN - 70306349; 18279104 AB - We sought to determine the safety, maximum tolerated dose, optimal dose, and preliminary dose efficacy of intermittent subcutaneously (s.c.) administered BAY 50-4798 among patients with HIV infection receiving highly active antiretroviral therapy (HAART) compared with patients receiving HAART alone. A phase I/II randomized, double-blind, dose-escalation study was conducted of the safety, tolerability, pharmacokinetics, and efficacy of s.c. BAY 50-4798 administered to HIV-infected patients already receiving stable HAART. There were no unexpected safety findings in a population of HIV-infected patients receiving HAART plus SC BAY 50-4798 as adjunctive therapy. BAY 50-4798 exhibited nearly dose-proportional pharmacokinetics, and accumulation was minimal during multiple-dose treatment. Limited efficacy data indicated that treatment with BAY 50-4798 caused at least a transient increase in CD4(+) T cell counts in some recipients, particularly at the early time points. In general, this effect appeared to increase with increasing dose. Bay 50-4798 was generally well tolerated across the dose range tested, but a lack of potent, sustained immunologic activity suggests that further optimization of dose and schedule will be necessary. JF - Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research AU - Davey, Richard T AU - Pertel, Peter E AU - Benson, Alice AU - Cassell, Delanie J AU - Gazzard, Brian G AU - Holodniy, Mark AU - Lalezari, Jacob P AU - Levy, Yves AU - Mitsuyasu, Ronald T AU - Palella, Frank J AU - Pollard, Richard B AU - Rajagopalan, Prabhu AU - Saag, Michael S AU - Salata, Robert A AU - Sha, Beverly E AU - Choudhri, Shurjeel AD - National Institutes of Health, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA. rdavey@niaid.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 89 EP - 100 VL - 28 IS - 2 SN - 1079-9907, 1079-9907 KW - Anti-HIV Agents KW - 0 KW - Cytokines KW - Interleukin-2 KW - Recombinant Proteins KW - aldesleukin KW - M89N0Q7EQR KW - Index Medicus KW - Lymphocyte Count KW - Double-Blind Method KW - Humans KW - Adult KW - Recombinant Proteins -- adverse effects KW - Injections, Subcutaneous KW - Recombinant Proteins -- pharmacokinetics KW - Middle Aged KW - Cytokines -- metabolism KW - Maximum Tolerated Dose KW - Recombinant Proteins -- administration & dosage KW - Male KW - Female KW - Interleukin-2 -- adverse effects KW - Interleukin-2 -- administration & dosage KW - Anti-HIV Agents -- pharmacokinetics KW - Interleukin-2 -- analogs & derivatives KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy KW - HIV Infections -- metabolism KW - Antiretroviral Therapy, Highly Active KW - Anti-HIV Agents -- adverse effects KW - Anti-HIV Agents -- administration & dosage KW - Interleukin-2 -- agonists KW - Interleukin-2 -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70306349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interferon+%26+cytokine+research+%3A+the+official+journal+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Safety%2C+tolerability%2C+pharmacokinetics%2C+and+efficacy+of+an+interleukin-2+agonist+among+HIV-infected+patients+receiving+highly+active+antiretroviral+therapy.&rft.au=Davey%2C+Richard+T%3BPertel%2C+Peter+E%3BBenson%2C+Alice%3BCassell%2C+Delanie+J%3BGazzard%2C+Brian+G%3BHolodniy%2C+Mark%3BLalezari%2C+Jacob+P%3BLevy%2C+Yves%3BMitsuyasu%2C+Ronald+T%3BPalella%2C+Frank+J%3BPollard%2C+Richard+B%3BRajagopalan%2C+Prabhu%3BSaag%2C+Michael+S%3BSalata%2C+Robert+A%3BSha%2C+Beverly+E%3BChoudhri%2C+Shurjeel&rft.aulast=Davey&rft.aufirst=Richard&rft.date=2008-02-01&rft.volume=28&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Journal+of+interferon+%26+cytokine+research+%3A+the+official+journal+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/10.1089%2Fjir.2007.0064 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-14 N1 - Date created - 2008-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/jir.2007.0064 ER - TY - JOUR T1 - Association of Epstein-Barr virus antibody levels with precancerous gastric lesions in a high-risk cohort. AN - 70292339; 18201267 AB - We evaluated associations between Epstein-Barr virus (EBV) antibody levels and precancerous gastric lesions (chronic atrophic gastritis, intestinal metaplasia, and dysplasia) in 183 subjects from Linqu, China. Immunoglobulin G antibody titers to EBV nuclear antigen (EBNA) and viral capsid antigen (VCA) were determined by two-fold serial dilution using immunofluorescence assays. Histological progression and regression were assessed by gastroscopic examination at the time of phlebotomy and at follow up 2 years later. Antibody titers did not differ significantly among histological diagnoses determined at the time of phlebotomy. However, subjects with dysplasia at follow up had significantly higher geometric mean antibody titers for both anti-VCA and anti-EBNA. Subjects with greater than median antibody levels were more likely to progress between examinations, especially in the subgroup with intestinal metaplasia at the time of phlebotomy (odds ratios [95% confidence intervals]: 5.7 [1.6-20] for anti-EBNA >or=1:320; 3.8 [1.0-15] for anti-VCA >or=1:640). Our findings suggest a possible role for EBV reactivation at an early phase of gastric carcinogenesis. JF - Cancer science AU - Schetter, Aaron J AU - You, Wei-cheng AU - Lennette, Evelyne T AU - Gail, Mitchell T AU - Rabkin, Charles S AD - Cancer Prevention Fellowship Program, National Cancer Institute, National Institute of Health, 6120 Executive Boulevard, Bethesda, MD 20892-7335, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 350 EP - 354 VL - 99 IS - 2 KW - Antibodies, Viral KW - 0 KW - Epstein-Barr Virus Nuclear Antigens KW - Index Medicus KW - Intestines -- pathology KW - Humans KW - Epstein-Barr Virus Nuclear Antigens -- immunology KW - Metaplasia KW - Adult KW - Cohort Studies KW - Gastritis, Atrophic -- pathology KW - Stomach -- abnormalities KW - Middle Aged KW - China KW - Female KW - Male KW - Epstein-Barr Virus Infections -- immunology KW - Antibodies, Viral -- blood KW - Stomach Neoplasms -- pathology KW - Stomach Neoplasms -- immunology KW - Precancerous Conditions -- immunology KW - Herpesvirus 4, Human -- immunology KW - Precancerous Conditions -- virology KW - Precancerous Conditions -- pathology KW - Stomach Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70292339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+science&rft.atitle=Association+of+Epstein-Barr+virus+antibody+levels+with+precancerous+gastric+lesions+in+a+high-risk+cohort.&rft.au=Schetter%2C+Aaron+J%3BYou%2C+Wei-cheng%3BLennette%2C+Evelyne+T%3BGail%2C+Mitchell+T%3BRabkin%2C+Charles+S&rft.aulast=Schetter&rft.aufirst=Aaron&rft.date=2008-02-01&rft.volume=99&rft.issue=2&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Cancer+science&rft.issn=1349-7006&rft_id=info:doi/10.1111%2Fj.1349-7006.2007.00668.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-22 N1 - Date created - 2008-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1349-7006.2007.00668.x ER - TY - JOUR T1 - Stoichiometry and absolute quantification of proteins with mass spectrometry using fluorescent and isotope-labeled concatenated peptide standards. AN - 70284186; 18029347 AB - We have explored a general approach for the determination of absolute amounts and the relative stoichiometry of proteins in a mixture using fluorescence and mass spectrometry. We engineered a gene to express green fluorescent protein (GFP) with a synthetic fusion protein (GAB-GFP) in Escherichia coli to function as a spectroscopic standard for the quantification of an analogous stable isotope-labeled, non-fluorescent fusion protein (GAB*) and for the quantification and stoichiometric analysis of purified transducin, a heterotrimeric G-protein complex. Both GAB-GFP and GAB* contain concatenated sequences of specific proteotypic peptides that are derived from the alpha, beta, and gamma protein subunits of transducin and that are each flanked by spacer regions that maintain the native proteolytic properties for these peptide fragments. Spectroscopic quantification of GAB-GFP provided a molar scale for mass spectrometric ratios from tryptic peptides of GAB* and defined molar responses for mass spectrometric signal intensities from a purified transducin complex. The stoichiometry of transducin subunits alpha, beta, and gamma was measured to be 1:1.1:1.15 over a 5-fold range of labeled internal standard with a relative standard deviation of 9%. Fusing a unique genetically coded spectroscopic signal element with concatenated proteotypic peptides provides a powerful method to accurately quantify and determine the relative stoichiometry of multiple proteins present in complexes or mixtures that cannot be readily assessed using classical gravimetric, enzymatic, or antibody-based technologies. JF - Molecular & cellular proteomics : MCP AU - Nanavati, Dhaval AU - Gucek, Marjan AU - Milne, Jacqueline L S AU - Subramaniam, Sriram AU - Markey, Sanford P AD - Laboratory of Neurotoxicology, National Institute of Mental Health, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 442 EP - 447 VL - 7 IS - 2 KW - Peptides KW - 0 KW - Protein Subunits KW - Proteins KW - Recombinant Fusion Proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Trypsin KW - EC 3.4.21.4 KW - Transducin KW - EC 3.6.5.1 KW - Index Medicus KW - Animals KW - Reproducibility of Results KW - Transducin -- chemistry KW - Protein Processing, Post-Translational KW - Reference Standards KW - Amino Acid Sequence KW - Protein Subunits -- metabolism KW - Protein Subunits -- chemistry KW - Isotope Labeling KW - Recombinant Fusion Proteins -- chemistry KW - Recombinant Fusion Proteins -- metabolism KW - Cattle KW - Molecular Sequence Data KW - Trypsin -- metabolism KW - Time Factors KW - Transducin -- metabolism KW - Mass Spectrometry KW - Proteins -- chemistry KW - Green Fluorescent Proteins -- chemistry KW - Peptides -- metabolism KW - Peptides -- chemistry KW - Proteins -- analysis KW - Green Fluorescent Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70284186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+%26+cellular+proteomics+%3A+MCP&rft.atitle=Stoichiometry+and+absolute+quantification+of+proteins+with+mass+spectrometry+using+fluorescent+and+isotope-labeled+concatenated+peptide+standards.&rft.au=Nanavati%2C+Dhaval%3BGucek%2C+Marjan%3BMilne%2C+Jacqueline+L+S%3BSubramaniam%2C+Sriram%3BMarkey%2C+Sanford+P&rft.aulast=Nanavati&rft.aufirst=Dhaval&rft.date=2008-02-01&rft.volume=7&rft.issue=2&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Molecular+%26+cellular+proteomics+%3A+MCP&rft.issn=1535-9484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Individual and geographic variation of skin alkaloids in three species of Madagascan poison frogs (Mantella). AN - 70282160; 18196341 AB - Alkaloid profiles for 81 individual mantellid frogs, Mantella baroni (Boulenger 1988) (N = 19), M. bernhardi (N = 51), and M. madagascariensis (Grandidier 1877) (N = 11), from six different populations from Madagascar were examined. Marked individual differences in alkaloid composition (number, type, and amount) were observed between different species and between populations of the same species. Disjunct populations of each of the three species differed significantly in alkaloid composition. Sympatric populations of M. baroni and M. madagascariensis also differed significantly in alkaloid composition. In M. bernhardi, differences in alkaloid composition were marginally associated with different sexes. A total of 111 alkaloids, including isomers, were detected in analysis of the individuals from the three species. The majority (47%) appear likely to be obtained from dietary mites, whereas many of the others (18%) are presumed to be from ants, and a few (4%) are from millipedes. Putative dietary sources for the remaining alkaloids are generally unknown, but beetles are probably the source of at least some of the tricyclic alkaloids (6%). In addition, alkaloid compositions from extracts of groups of individuals from five additional populations of M. baroni and from one population of M. bernhardi (Vences et al. 1994) and one population of M. cowanii (Boulenger 1882) were examined. An additional 50 alkaloids, including isomers, were detected in the combined samples, bringing the total number of alkaloids identified from these four species of mantellid frogs to 161. Alkaloid compositions in mantellid poison frogs are diverse and highly dependent on geographic location that appear to be largely determined by the nature and availability of alkaloid-containing prey items. JF - Journal of chemical ecology AU - Daly, John W AU - Garraffo, H Martin AU - Spande, Thomas F AU - Giddings, Lesley-Ann AU - Saporito, Ralph A AU - Vieites, David R AU - Vences, Miguel AD - Laboratory of Bioorganic Chemistry, HHS, NIDDK, NIH, Bethesda, MD 20892, USA. jdaly@nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 252 EP - 279 VL - 34 IS - 2 SN - 0098-0331, 0098-0331 KW - Alkaloids KW - 0 KW - Index Medicus KW - Animals KW - Geography KW - Male KW - Madagascar KW - Female KW - Skin -- chemistry KW - Anura KW - Alkaloids -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70282160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+ecology&rft.atitle=Individual+and+geographic+variation+of+skin+alkaloids+in+three+species+of+Madagascan+poison+frogs+%28Mantella%29.&rft.au=Daly%2C+John+W%3BGarraffo%2C+H+Martin%3BSpande%2C+Thomas+F%3BGiddings%2C+Lesley-Ann%3BSaporito%2C+Ralph+A%3BVieites%2C+David+R%3BVences%2C+Miguel&rft.aulast=Daly&rft.aufirst=John&rft.date=2008-02-01&rft.volume=34&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+ecology&rft.issn=00980331&rft_id=info:doi/10.1007%2Fs10886-007-9396-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-15 N1 - Date created - 2008-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10886-007-9396-9 ER - TY - JOUR T1 - Ensuring the safety of botanical dietary supplements. AN - 70281702; 18258648 AB - Botanical dietary supplements with a history of safe human use may not require the same level of toxicity testing as synthetic pharmaceutical drugs. Most of the documented examples of acute toxicity caused by botanical dietary supplements have been caused by the substitution of toxic plants for the desired species, probably through misidentification or production errors, or by contamination with pharmaceutical agents, either as a result of poor manufacturing practices or adulteration. Although more difficult to document, chronic toxicities attributed to botanical dietary supplements may be caused by contamination by heavy metals, pesticides, or microbes or by inherent properties of constituents of the botanicals themselves. Like drug-drug interactions, botanical-drug interactions can also be a source of toxicity. Most of these toxicity problems may be prevented by implementing good agricultural practices and good manufacturing practices and applying existing toxicity testing similar to those used in drug development or new toxicity assays under development based on proteomics, genomics, or metabolomics. JF - The American journal of clinical nutrition AU - van Breemen, Richard B AU - Fong, Harry Hs AU - Farnsworth, Norman R AD - University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, L 60612, USA. breemen@uic.edu Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 509S EP - 13S VL - 87 IS - 2 SN - 0002-9165, 0002-9165 KW - Plant Preparations KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Phytotherapy KW - Humans KW - Complementary Therapies -- standards KW - Safety KW - Drug Contamination -- prevention & control KW - Plant Preparations -- standards KW - Plant Preparations -- toxicity KW - Dietary Supplements -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70281702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Ensuring+the+safety+of+botanical+dietary+supplements.&rft.au=van+Breemen%2C+Richard+B%3BFong%2C+Harry+Hs%3BFarnsworth%2C+Norman+R&rft.aulast=van+Breemen&rft.aufirst=Richard&rft.date=2008-02-01&rft.volume=87&rft.issue=2&rft.spage=509S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New structures help the modeling of toxic amyloidbeta ion channels. AN - 70280194; 18182298 AB - The mechanism of amyloid toxicity is poorly understood and there are two schools of thought in this hotly debated field: the first favors membrane destabilization by intermediate-to-large amyloid oligomers, with consequent thinning and non-specific ion leakage; the second favors ion-specific permeable channels lined by small amyloid oligomers. Published results currently support both mechanisms. However, the amyloidbeta (Abeta) peptide has recently been shown to form a U-shaped 'beta-strand-turn-beta-strand' structure. This structure and the available physiological data present a challenge for computational biology--to provide candidate models consistent with the experimental data. Modeling based on small Abeta oligomers containing extramembranous N-termini predicts channels with shapes and dimensions consistent with experimentally derived channel structures. These results support the hypothesis that small Abeta oligomers can form ion channels. Molecular dynamics modeling can provide blueprints of 3D structural conformations for many other amyloids whose membrane association is key to their toxicity. JF - Trends in biochemical sciences AU - Jang, Hyunbum AU - Zheng, Jie AU - Lal, Ratnesh AU - Nussinov, Ruth AD - Center for Cancer Research Nanobiology Program, SAIC-Frederick Inc. NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 91 EP - 100 VL - 33 IS - 2 SN - 0968-0004, 0968-0004 KW - Amyloid beta-Peptides KW - 0 KW - Ion Channels KW - Index Medicus KW - Models, Molecular KW - Protein Folding KW - Cell Membrane -- ultrastructure KW - Cell Membrane -- metabolism KW - Ion Channels -- chemistry KW - Amyloid beta-Peptides -- toxicity KW - Amyloid beta-Peptides -- chemistry KW - Protein Conformation KW - Ion Channels -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70280194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+biochemical+sciences&rft.atitle=New+structures+help+the+modeling+of+toxic+amyloidbeta+ion+channels.&rft.au=Jang%2C+Hyunbum%3BZheng%2C+Jie%3BLal%2C+Ratnesh%3BNussinov%2C+Ruth&rft.aulast=Jang&rft.aufirst=Hyunbum&rft.date=2008-02-01&rft.volume=33&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Trends+in+biochemical+sciences&rft.issn=09680004&rft_id=info:doi/10.1016%2Fj.tibs.2007.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-22 N1 - Date created - 2008-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tibs.2007.10.007 ER - TY - JOUR T1 - Liver: An organ with predominant innate immunity. AN - 70271062; 18167066 AB - Blood circulating from the intestines to the liver is rich in bacterial products, environmental toxins, and food antigens. To effectively and quickly defend against potentially toxic agents without launching harmful immune responses, the liver relies on its strong innate immune system. This comprises enrichment of innate immune cells (such as macrophages, natural killer, natural killer T, and gammadelta T cells) and removal of waste molecules and immunologic elimination of microorganisms by liver endothelial cells and Kupffer cells. In addition, the liver also plays an important role in controlling systemic innate immunity through the biosynthesis of numerous soluble pathogen-recognition receptors and complement components. The liver is an organ with predominant innate immunity, playing an important role not only in host defenses against invading microorganisms and tumor transformation but also in liver injury and repair. Recent evidence suggests that innate immunity is also involved in the pathogenesis of liver fibrosis, providing novel therapeutic targets to treat such a liver disorder. JF - Hepatology (Baltimore, Md.) AU - Gao, Bin AU - Jeong, Won-Il AU - Tian, Zhigang AD - Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. bgao@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 729 EP - 736 VL - 47 IS - 2 KW - Complement System Proteins KW - 9007-36-7 KW - Index Medicus KW - Animals KW - Hepatocytes -- immunology KW - Kupffer Cells -- immunology KW - Humans KW - Complement System Proteins -- physiology KW - Hepatocytes -- physiology KW - T-Lymphocytes -- immunology KW - Killer Cells, Natural -- immunology KW - Complement Activation KW - Immunity, Innate -- immunology KW - Liver -- immunology KW - Liver Circulation -- immunology KW - Liver Circulation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70271062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Liver%3A+An+organ+with+predominant+innate+immunity.&rft.au=Gao%2C+Bin%3BJeong%2C+Won-Il%3BTian%2C+Zhigang&rft.aulast=Gao&rft.aufirst=Bin&rft.date=2008-02-01&rft.volume=47&rft.issue=2&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.22034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/hep.22034 ER - TY - JOUR T1 - Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. AN - 70269074; 18157835 AB - Herbal products, used for centuries in Far Eastern countries, are gaining popularity in western countries. Surveys indicate that persons with chronic hepatitis C (CHC) often use herbals, especially silymarin (milk thistle extract), hoping to improve the modest response to antiviral therapy and reduce side effects. The Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, involving persons with advanced CHC, nonresponders to prior antiviral therapy but still willing to participate in long-term pegylated interferon treatment, offered the opportunity to examine the use and potential effects of silymarin. Among 1145 study participants, 56% had never taken herbals, 21% admitted past use, and 23% were using them at enrollment. Silymarin constituted 72% of 60 herbals used at enrollment. Among all participants, 67% had never used silymarin, 16% used it in the past, and 17% used it at baseline. Silymarin use varied widely among the 10 participating study centers; men were more frequent users than women, as were non-Hispanic whites than African Americans and Hispanics. Silymarin use correlated strongly with higher education. No beneficial effect of silymarin was found on serum alanine aminotransferase or hepatitis C virus (HCV) RNA levels. Univariate analysis showed significantly fewer liver-related symptoms and better quality-of-life parameters in users than nonusers, but after reanalysis adjusted for covariates of age, race, education, alcohol consumption, exercise, body mass index, and smoking, only fatigue, nausea, liver pain, anorexia, muscle and joint pain, and general health remained significantly better in silymarin users. In conclusion, silymarin users had similar alanine aminotransferase and HCV levels to those of nonusers but fewer symptoms and somewhat better quality-of-life indices. Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C. JF - Hepatology (Baltimore, Md.) AU - Seeff, Leonard B AU - Curto, Teresa M AU - Szabo, Gyongyi AU - Everson, Gregory T AU - Bonkovsky, Herbert L AU - Dienstag, Jules L AU - Shiffman, Mitchell L AU - Lindsay, Karen L AU - Lok, Anna S F AU - Di Bisceglie, Adrian M AU - Lee, William M AU - Ghany, Marc G AU - HALT-C Trial Group AD - Division of Digestive Diseases and Nutrition, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. seeffl@extra.niddk.nih.gov ; HALT-C Trial Group Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 605 EP - 612 VL - 47 IS - 2 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - Silymarin KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - interferon alfa-2a KW - 47RRR83SK7 KW - peginterferon alfa-2b KW - G8RGG88B68 KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Antiviral Agents -- therapeutic use KW - Silymarin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Silymarin -- adverse effects KW - Polyethylene Glycols -- therapeutic use KW - Humans KW - Interviews as Topic KW - Biopsy KW - Patient Selection KW - Liver Function Tests KW - Liver Cirrhosis -- prevention & control KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Herbal Medicine -- statistics & numerical data KW - Hepatitis C, Chronic -- therapy KW - Hepatitis C, Chronic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70269074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Herbal+product+use+by+persons+enrolled+in+the+hepatitis+C+Antiviral+Long-Term+Treatment+Against+Cirrhosis+%28HALT-C%29+Trial.&rft.au=Seeff%2C+Leonard+B%3BCurto%2C+Teresa+M%3BSzabo%2C+Gyongyi%3BEverson%2C+Gregory+T%3BBonkovsky%2C+Herbert+L%3BDienstag%2C+Jules+L%3BShiffman%2C+Mitchell+L%3BLindsay%2C+Karen+L%3BLok%2C+Anna+S+F%3BDi+Bisceglie%2C+Adrian+M%3BLee%2C+William+M%3BGhany%2C+Marc+G%3BHALT-C+Trial+Group&rft.aulast=Seeff&rft.aufirst=Leonard&rft.date=2008-02-01&rft.volume=47&rft.issue=2&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 2008 Jul;48(1):345-6 [18509876] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physiology of the motor cortex in polio survivors. AN - 70266327; 17990291 AB - We hypothesized that the corticospinal system undergoes functional changes in long-term polio survivors. Central motor conduction times (CMCTs) to the four limbs were measured in 24 polio survivors using transcranial magnetic stimulation (TMS). Resting motor thresholds and CMCTs were normal. In 17 subjects whose legs were affected by polio and 13 healthy controls, single- and paired-pulse TMS was used to assess motor cortex excitability while recording from tibialis anterior (TA) muscles at rest and following maximal contraction until fatigue. In polio survivors the slope of the recruitment curve was normal, but maximal motor evoked potentials (MEPs) were larger than in controls. MEPs were depressed after fatiguing exercise. Three patients with central fatigue by twitch interpolation had a trend toward slower recovery. There was no association with symptoms of post-polio syndrome. These changes occurring after polio may allow the motor cortex to activate a greater proportion of the motor neurons innervating affected muscles. JF - Muscle & nerve AU - Lupu, Vitalie D AU - Danielian, Laura AU - Johnsen, Jacqueline A AU - Vasconcelos, Olavo M AU - Prokhorenko, Olga A AU - Jabbari, Bahman AU - Campbell, William W AU - Floeter, Mary Kay AD - EMG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, CRC, 7-5680, 10 Center Drive, MSC-1404 Bethesda, Maryland 20892, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 177 EP - 182 VL - 37 IS - 2 SN - 0148-639X, 0148-639X KW - Index Medicus KW - Electric Stimulation -- methods KW - Fatigue KW - Neural Inhibition -- radiation effects KW - Transcranial Magnetic Stimulation -- methods KW - Humans KW - Muscle, Skeletal -- innervation KW - Neural Conduction -- radiation effects KW - Electromyography KW - Aged KW - Dose-Response Relationship, Radiation KW - Neural Inhibition -- physiology KW - Physical Endurance KW - Neural Conduction -- physiology KW - Middle Aged KW - Female KW - Male KW - Motor Cortex -- virology KW - Motor Cortex -- physiopathology KW - Evoked Potentials, Motor -- physiology KW - Postpoliomyelitis Syndrome -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70266327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Muscle+%26+nerve&rft.atitle=Physiology+of+the+motor+cortex+in+polio+survivors.&rft.au=Lupu%2C+Vitalie+D%3BDanielian%2C+Laura%3BJohnsen%2C+Jacqueline+A%3BVasconcelos%2C+Olavo+M%3BProkhorenko%2C+Olga+A%3BJabbari%2C+Bahman%3BCampbell%2C+William+W%3BFloeter%2C+Mary+Kay&rft.aulast=Lupu&rft.aufirst=Vitalie&rft.date=2008-02-01&rft.volume=37&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Muscle+%26+nerve&rft.issn=0148639X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-17 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00080600; ClinicalTrials.gov N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental genotoxicants/carcinogens and childhood cancer: filling knowledge gaps. AN - 70262358; 18237856 JF - Current problems in pediatric and adolescent health care AU - Anderson, Lucy M AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Ft. Detrick, Frederick, MD, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 50 EP - 63 VL - 38 IS - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70262358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+problems+in+pediatric+and+adolescent+health+care&rft.atitle=Environmental+genotoxicants%2Fcarcinogens+and+childhood+cancer%3A+filling+knowledge+gaps.&rft.au=Anderson%2C+Lucy+M&rft.aulast=Anderson&rft.aufirst=Lucy&rft.date=2008-02-01&rft.volume=38&rft.issue=2&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Current+problems+in+pediatric+and+adolescent+health+care&rft.issn=1538-3199&rft_id=info:doi/10.1016%2Fj.cppeds.2007.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Reprint Of: Mutat Res. 2006 Sep 28;608(2):136-56 [16829162] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cppeds.2007.11.002 ER - TY - JOUR T1 - Environmental factors and puberty timing: expert panel research needs. AN - 70262071; 18245512 AB - Serono Symposia International convened an expert panel to review the impact of environmental influences on the regulation of pubertal onset and progression while identifying critical data gaps and future research priorities. An expert panel reviewed the literature on endocrine-disrupting chemicals, body size, and puberty. The panel concluded that available experimental animal and human data support a possible role of endocrine-disrupting chemicals and body size in relation to alterations in pubertal onset and progression in boys and girls. Critical data gaps prioritized for future research initiatives include (1) etiologic research that focus on environmentally relevant levels of endocrine-disrupting chemicals and body size in relation to normal puberty as well as its variants, (2) exposure assessment of relevant endocrine-disrupting chemicals during critical windows of human development, and (3) basic research to identify the primary signal(s) for the onset of gonadotropin-releasing hormone-dependent/central puberty and gonadotropin-releasing hormone-independent/peripheral puberty. Prospective studies of couples who are planning pregnancies or pregnant women are needed to capture the continuum of exposures at critical windows while assessing a spectrum of pubertal markers as outcomes. Coupled with comparative species studies, such research may provide insight regarding the causal ordering of events that underlie pubertal onset and progression and their role in the pathway of adult-onset disease. JF - Pediatrics AU - Buck Louis, Germaine M AU - Gray, L Earl AU - Marcus, Michele AU - Ojeda, Sergio R AU - Pescovitz, Ora H AU - Witchel, Selma Feldman AU - Sippell, Wolfgang AU - Abbott, David H AU - Soto, Ana AU - Tyl, Rochelle W AU - Bourguignon, Jean-Pierre AU - Skakkebaek, Niels E AU - Swan, Shanna H AU - Golub, Mari S AU - Wabitsch, Martin AU - Toppari, Jorma AU - Euling, Susan Y AD - Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA. louisg@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - S192 EP - S207 VL - 121 Suppl 3 KW - Endocrine Disruptors KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Endocrine Disruptors -- adverse effects KW - Sexual Maturation -- physiology KW - Age Factors KW - Humans KW - Child KW - Puberty, Precocious -- etiology KW - Puberty, Precocious -- prevention & control KW - Male KW - Female KW - Puberty -- physiology KW - Environmental Exposure -- prevention & control KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70262071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Pediatrics&rft.atitle=Environmental+factors+and+puberty+timing%3A+expert+panel+research+needs.&rft.au=Buck+Louis%2C+Germaine+M%3BGray%2C+L+Earl%3BMarcus%2C+Michele%3BOjeda%2C+Sergio+R%3BPescovitz%2C+Ora+H%3BWitchel%2C+Selma+Feldman%3BSippell%2C+Wolfgang%3BAbbott%2C+David+H%3BSoto%2C+Ana%3BTyl%2C+Rochelle+W%3BBourguignon%2C+Jean-Pierre%3BSkakkebaek%2C+Niels+E%3BSwan%2C+Shanna+H%3BGolub%2C+Mari+S%3BWabitsch%2C+Martin%3BToppari%2C+Jorma%3BEuling%2C+Susan+Y&rft.aulast=Buck+Louis&rft.aufirst=Germaine&rft.date=2008-02-01&rft.volume=121+Suppl+3&rft.issue=&rft.spage=S192&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.1813E LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-03 N1 - Date created - 2008-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.1813E ER - TY - JOUR T1 - In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide. AN - 70260637; 18245557 AB - Temozolomide, a DNA methylating agent, is currently undergoing clinical evaluation for cancer therapy. Because temozolomide has been shown to increase survival rates of patients with malignant gliomas when given combined with radiation, and there is conflicting preclinical data concerning the radiosensitizing effects of temozolomide, we further investigated the possible temozolomide-induced enhancement of radiosensitivity. The effects of temozolomide on the in vitro radiosensitivity of U251 (a human glioma) and MDA-MB231BR (a brain-seeking variant of a human breast tumor) cell lines was evaluated using clonogenic assay. DNA damage and repair were evaluated using phosphorylated histone H2AX (gammaH2AX), and mitotic catastrophe was measured using nuclear fragmentation. Growth delay was used to evaluate the effects of temozolomide on in vivo (U251) tumor radiosensitivity. Exposure of each cell line to temozolomide for 1 h before irradiation resulted in an increase in radiosensitivity with dose enhancement factors at a surviving fraction of 0.1 ranging from 1.30 to 1.32. Temozolomide had no effect on radiation-induced apoptosis or on the activation of the G(2) cell cycle checkpoint. As a measure of DNA double strand breaks, gammaH2AX foci were determined as a function of time after the temozolomide + irradiation combination. The number of gammaH2AX foci per cell was significantly greater at 24 h after the combined modality compared with the individual treatments. Mitotic catastrophe, measured at 72 h, was also significantly increased in cells receiving the temozolomide + irradiation combination compared with the single treatments. In vivo studies revealed that temozolomide administration to mice bearing U251 tumor xenografts resulted in a greater than additive increase in radiation-induced tumor growth delay with a dose enhancement factor of 2.8. These results indicate that temozolomide can enhance tumor cell radiosensitivity in vitro and in vivo and suggest that this effect involves an inhibition of DNA repair leading to an increase in mitotic catastrophe. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kil, Whoon Jong AU - Cerna, David AU - Burgan, William E AU - Beam, Katie AU - Carter, Donna AU - Steeg, Patricia S AU - Tofilon, Philip J AU - Camphausen, Kevin AD - Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 931 EP - 938 VL - 14 IS - 3 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Radiation-Sensitizing Agents KW - Dacarbazine KW - 7GR28W0FJI KW - temozolomide KW - YF1K15M17Y KW - Index Medicus KW - Glioblastoma KW - Brain Neoplasms KW - DNA Methylation KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Humans KW - Apoptosis -- drug effects KW - Mitosis -- drug effects KW - Cell Line, Tumor KW - Tumor Stem Cell Assay KW - DNA Replication -- drug effects KW - Cell Cycle -- drug effects KW - Dacarbazine -- analogs & derivatives KW - Radiation-Sensitizing Agents -- pharmacology KW - Dacarbazine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70260637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=In+vitro+and+in+vivo+radiosensitization+induced+by+the+DNA+methylating+agent+temozolomide.&rft.au=Kil%2C+Whoon+Jong%3BCerna%2C+David%3BBurgan%2C+William+E%3BBeam%2C+Katie%3BCarter%2C+Donna%3BSteeg%2C+Patricia+S%3BTofilon%2C+Philip+J%3BCamphausen%2C+Kevin&rft.aulast=Kil&rft.aufirst=Whoon&rft.date=2008-02-01&rft.volume=14&rft.issue=3&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-1856 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-1856 ER - TY - JOUR T1 - Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound. AN - 70259630; 18178089 AB - Structural analogues of JS-K, an anti-cancer lead compound, were prepared and their in vitro anti-leukemic activity was determined. The rate of nitric oxide release from the corresponding diazeniumdiolate anions did not appear to affect the anti-leukemic activity of the prodrug forms. Two compounds with potent inhibitory activity and a potentially favorable toxicological profile were identified. JF - Bioorganic & medicinal chemistry letters AU - Chakrapani, Harinath AU - Goodblatt, Michael M AU - Udupi, Vidya AU - Malaviya, Swati AU - Shami, Paul J AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, PO Box B, Frederick, MD 21702, USA. chakrah@ncifcrf.gov Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 950 EP - 953 VL - 18 IS - 3 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antineoplastic Agents KW - Azo Compounds KW - Nitric Oxide Donors KW - O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate KW - Piperazines KW - Prodrugs KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Nitric Oxide Donors -- pharmacology KW - Molecular Structure KW - Anti-Inflammatory Agents, Non-Steroidal -- chemistry KW - Models, Molecular KW - Leukemia -- metabolism KW - HL-60 Cells KW - Prodrugs -- pharmacology KW - Humans KW - Glutathione -- metabolism KW - Combinatorial Chemistry Techniques KW - Nitric Oxide Donors -- chemistry KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Azo Compounds -- chemical synthesis KW - Piperazines -- chemical synthesis KW - Piperazines -- chemistry KW - Azo Compounds -- chemistry KW - Glutathione Transferase -- metabolism KW - Azo Compounds -- pharmacology KW - Antineoplastic Agents -- chemical synthesis KW - Piperazines -- pharmacology KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70259630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.atitle=Synthesis+and+in+vitro+anti-leukemic+activity+of+structural+analogues+of+JS-K%2C+an+anti-cancer+lead+compound.&rft.au=Chakrapani%2C+Harinath%3BGoodblatt%2C+Michael+M%3BUdupi%2C+Vidya%3BMalaviya%2C+Swati%3BShami%2C+Paul+J%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2008-02-01&rft.volume=18&rft.issue=3&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry+letters&rft.issn=1464-3405&rft_id=info:doi/10.1016%2Fj.bmcl.2007.12.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-24 N1 - Date created - 2008-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Chem Rev. 2002 Apr;102(4):1135-54 [11942789] Org Lett. 2007 Oct 25;9(22):4551-4 [17918856] Annu Rev Pharmacol Toxicol. 2003;43:585-607 [12415121] Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] J Cell Physiol. 2003 Dec;197(3):426-34 [14566972] Oncogene. 2003 Oct 20;22(47):7369-75 [14576844] Mol Cancer Ther. 2004 Jun;3(6):709-14 [15210857] Food Cosmet Toxicol. 1976 Apr;14(2):133-5 [178581] J Natl Cancer Inst. 1980 Jun;64(6):1435-42 [6929379] Cancer Metastasis Rev. 1987;6(3):301-56 [3319273] Mutat Res. 1991 Apr;252(2):119-28 [1901957] Chem Res Toxicol. 1991 Mar-Apr;4(2):131-40 [1782341] Methods Enzymol. 1996;268:281-93 [8782594] J Med Chem. 1996 Oct 25;39(22):4361-5 [8893830] Chem Res Toxicol. 1997 Jan;10(1):2-18 [9074797] Leukemia. 1998 Sep;12(9):1461-6 [9737697] Bioorg Med Chem. 2005 Apr 15;13(8):2749-57 [15781386] J Med Chem. 2005 Jun 16;48(12):4061-7 [15943479] Expert Opin Investig Drugs. 2005 Jul;14(7):835-46 [16022573] Curr Top Med Chem. 2005;5(7):625-36 [16101424] J Pharm Sci. 2006 Jan;95(1):108-15 [16315224] Curr Med Chem. 2006;13(12):1461-71 [16719788] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] Leuk Res. 2006 Oct;30(10):1279-83 [16439016] Bioorg Med Chem. 2007 Jul 15;15(14):4767-74 [17509888] Blood. 2007 Jul 15;110(2):709-18 [17384201] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Arch Toxicol. 2002 Oct;76(10):606-12 [12373457] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmcl.2007.12.044 ER - TY - JOUR T1 - Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. AN - 70257529; 18188453 AB - The mechanisms underlying the susceptibility of individuals with caspase recruitment domain 15 (CARD15) mutations and corresponding abnormalities of nucleotide-binding oligomerization domain 2 (NOD2) protein to Crohn disease are still poorly understood. One possibility is based on previous studies showing that muramyl dipeptide (MDP) activation of NOD2 negatively regulates TLR2 responses and that absence of such regulation leads to heightened Th1 responses. We now report that administration of MDP protects mice from the development of experimental colitis by downregulating multiple TLR responses, not just TLR2. The basis of these in vivo findings was suggested by in vitro studies of DCs, in which we showed that prestimulation of cells with MDP reduces cytokine responses to multiple TLR ligands and this reduction is dependent on enhanced IFN regulatory factor 4 (IRF4) activity. Further studies of mouse models of colitis showed that this inhibitory role of IRF4 does in fact apply to MDP-mediated protection from colitis, since neither IRF4-deficient mice nor mice treated with siRNA specific for IRF4 were protected. These findings indicate that MDP activation of NOD2 regulates innate responses to intestinal microflora by downregulating multiple TLR responses and suggest that the absence of such regulation leads to increased susceptibility to Crohn disease. JF - The Journal of clinical investigation AU - Watanabe, Tomohiro AU - Asano, Naoki AU - Murray, Peter J AU - Ozato, Keiko AU - Tailor, Prafullakumar AU - Fuss, Ivan J AU - Kitani, Atsushi AU - Strober, Warren AD - Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 545 EP - 559 VL - 118 IS - 2 SN - 0021-9738, 0021-9738 KW - Adjuvants, Immunologic KW - 0 KW - Cytokines KW - Interferon Regulatory Factors KW - Ligands KW - Nod2 Signaling Adaptor Protein KW - RNA, Small Interfering KW - Toll-Like Receptors KW - interferon regulatory factor-4 KW - Acetylmuramyl-Alanyl-Isoglutamine KW - 53678-77-6 KW - Trinitrobenzenesulfonic Acid KW - 8T3HQG2ZC4 KW - Abridged Index Medicus KW - Index Medicus KW - Trinitrobenzenesulfonic Acid -- toxicity KW - Toll-Like Receptors -- antagonists & inhibitors KW - Animals KW - Dendritic Cells -- immunology KW - Disease Susceptibility KW - Immunity, Innate -- drug effects KW - Interferon Regulatory Factors -- genetics KW - Dendritic Cells -- drug effects KW - Disease Models, Animal KW - Interferon Regulatory Factors -- metabolism KW - Mice KW - Cytokines -- metabolism KW - Mice, Mutant Strains KW - Down-Regulation KW - RNA, Small Interfering -- pharmacology KW - Interferon Regulatory Factors -- antagonists & inhibitors KW - Colitis -- prevention & control KW - Nod2 Signaling Adaptor Protein -- metabolism KW - Acetylmuramyl-Alanyl-Isoglutamine -- administration & dosage KW - Adjuvants, Immunologic -- administration & dosage KW - Colitis -- immunology KW - Crohn Disease -- drug therapy KW - Crohn Disease -- immunology KW - Colitis -- chemically induced KW - Nod2 Signaling Adaptor Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70257529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Muramyl+dipeptide+activation+of+nucleotide-binding+oligomerization+domain+2+protects+mice+from+experimental+colitis.&rft.au=Watanabe%2C+Tomohiro%3BAsano%2C+Naoki%3BMurray%2C+Peter+J%3BOzato%2C+Keiko%3BTailor%2C+Prafullakumar%3BFuss%2C+Ivan+J%3BKitani%2C+Atsushi%3BStrober%2C+Warren&rft.aulast=Watanabe&rft.aufirst=Tomohiro&rft.date=2008-02-01&rft.volume=118&rft.issue=2&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI33145 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 2005 Mar;115(3):695-702 [15765149] J Immunol. 2005 Mar 1;174(5):2573-81 [15728463] Inflamm Bowel Dis. 2005 Jun;11(6):541-50 [15905701] J Immunol. 2005 Jun 1;174(11):7096-103 [15905553] Lancet. 2005 May 21-27;365(9473):1794-6 [15910952] Annu Rev Biochem. 2005;74:355-83 [15952891] Infect Immun. 2005 Aug;73(8):5212-6 [16041042] Gut. 2005 Nov;54(11):1515-8 [16227353] Int Immunol. 2005 Nov;17(11):1463-71 [16172134] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15989-94 [16236719] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16001-6 [16243976] J Immunol. 2005 Nov 15;175(10):6570-9 [16272311] J Clin Invest. 2005 Nov;115(11):3057-71 [16239967] Infect Immun. 2005 Dec;73(12):7967-76 [16299289] J Biol Chem. 2005 Dec 2;280(48):40301-9 [16203728] Nat Rev Immunol. 2006 Jan;6(1):9-20 [16493424] Lancet. 2006 Feb 25;367(9511):668-78 [16503465] Immunity. 2006 Aug;25(2):319-29 [16879997] Immunity. 2006 Sep;25(3):473-85 [16949315] Inflamm Bowel Dis. 2007 Jul;13(7):856-64 [17393379] Gastroenterology. 2007 Nov;133(5):1510-21 [17915219] Nat Immunol. 2000 Oct;1(4):311-6 [11017102] Nature. 2001 May 31;411(6837):599-603 [11385576] Nature. 2001 May 31;411(6837):603-6 [11385577] Nat Immunol. 2001 Aug;2(8):675-80 [11477402] J Immunol. 2002 Mar 1;168(5):2188-99 [11859105] Annu Rev Immunol. 2002;20:495-549 [11861611] Cell. 2002 Jul 26;110(2):191-202 [12150927] J Biol Chem. 2002 Nov 1;277(44):41701-5 [12194982] J Biol Chem. 2003 Feb 21;278(8):5509-12 [12514169] J Biol Chem. 2003 Mar 14;278(11):8869-72 [12527755] Nat Rev Immunol. 2003 Jul;3(7):521-33 [12876555] Hepatology. 2003 Aug;38(2):403-12 [12883484] Mol Cell Biol. 2003 Nov;23(21):7531-9 [14560001] J Exp Med. 2003 Dec 15;198(12):1797-806 [14662907] Nat Immunol. 2004 Aug;5(8):800-8 [15220916] Proc Natl Acad Sci U S A. 1979 Dec;76(12):6557-61 [293743] Infect Immun. 1986 Sep;53(3):517-21 [3744549] Microbiol Immunol. 1986;30(7):717-23 [3773792] J Leukoc Biol. 1990 Feb;47(2):164-9 [2303750] J Exp Med. 1995 Nov 1;182(5):1281-90 [7595199] Clin Exp Immunol. 1999 May;116(2):238-45 [10337013] N Engl J Med. 2004 Nov 11;351(20):2069-79 [15537905] J Biol Chem. 2004 Dec 24;279(52):54702-7 [15491990] Cell Microbiol. 2005 Jan;7(1):53-61 [15617523] Science. 2005 Feb 4;307(5710):731-4 [15692051] Science. 2005 Feb 4;307(5710):734-8 [15692052] J Immunol. 2005 May 15;174(10):6518-23 [15879155] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1172/JCI33145 ER - TY - JOUR T1 - Tumor immunobiological differences in prostate cancer between African-American and European-American men. AN - 70256435; 18245496 AB - The incidence and mortality rates of prostate cancer are significantly higher in African-American men when compared with European-American men. We tested the hypothesis that differences in tumor biology contribute to this survival health disparity. Using microarray technology, we obtained gene expression profiles of primary prostate tumors resected from 33 African-American and 36 European-American patients. These tumors were matched on clinical variables. We also evaluated 18 nontumor prostate tissues from seven African-American and 11 European-American patients. The resulting datasets were analyzed for expression differences on the gene and pathway level comparing African-American with European-American patients. Our analysis revealed a significant number of genes, e.g., 162 transcripts at a false-discovery rate of or= 60 mL/min; mild dysfunction, CrCL 40 to 59 mL/min; moderate dysfunction, CrCL 20 to 39 mL/min; and severe dysfunction, CrCL < 20 mL/min) received daily imatinib doses of 100 to 800 mg. Treatment cycles were 28 days long. The MTD was not reached for any group. DLTs occurred in two mild group patients (600 and 800 mg) and two moderate group patients (200 and 600 mg). Serious adverse events (SAEs) were more common in the renal dysfunction groups than in the normal group (P = .0096). There was no correlation between dose and SAEs in any group. No responses were observed. Several patients had prolonged stable disease. Imatinib exposure, expressed as dose-normalized imatinib area under the curve, was significantly greater in the mild and moderate groups than in the normal group. There was a positive correlation between serum alpha-1 acid glycoprotein (AGP) concentration and plasma imatinib, and an inverse correlation between plasma AGP concentration and imatinib clearance. Urinary excretion accounted for 3% to 5% of the daily imatinib dose. Daily imatinib doses up to 800 or 600 mg were well tolerated by patients with mild and moderate renal dysfunction, respectively, despite their having increased imatinib exposure. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Gibbons, Joseph AU - Egorin, Merrill J AU - Ramanathan, Ramesh K AU - Fu, Pingfu AU - Mulkerin, Daniel L AU - Shibata, Stephen AU - Takimoto, Chris H M AU - Mani, Sridhar AU - LoRusso, Patricia A AU - Grem, Jean L AU - Pavlick, Anna AU - Lenz, Heinz-Josef AU - Flick, Susan M AU - Reynolds, Sherrie AU - Lagattuta, Theodore F AU - Parise, Robert A AU - Wang, Yanfeng AU - Murgo, Anthony J AU - Ivy, S Percy AU - Remick, Scot C AU - National Cancer Institute Organ Dysfunction Working Group AD - Case Comprehensive Cancer Center, Ireland Cancer Center at University Hospitals of Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, USA. ; National Cancer Institute Organ Dysfunction Working Group Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 570 EP - 576 VL - 26 IS - 4 KW - Antineoplastic Agents KW - 0 KW - Benzamides KW - Piperazines KW - Pyrimidines KW - Imatinib Mesylate KW - 8A1O1M485B KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Administration, Oral KW - Kidney Function Tests KW - Creatinine -- urine KW - Antineoplastic Agents -- administration & dosage KW - Area Under Curve KW - Hypophosphatemia -- chemically induced KW - Humans KW - Antineoplastic Agents -- pharmacokinetics KW - Aged KW - Creatinine -- blood KW - Antineoplastic Agents -- adverse effects KW - Biological Availability KW - Half-Life KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Piperazines -- pharmacokinetics KW - Pyrimidines -- adverse effects KW - Neoplasms -- drug therapy KW - Kidney Diseases -- metabolism KW - Neoplasms -- complications KW - Kidney Diseases -- etiology KW - Pyrimidines -- pharmacokinetics KW - Piperazines -- adverse effects KW - Pyrimidines -- administration & dosage KW - Piperazines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70251270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+and+pharmacokinetic+study+of+imatinib+mesylate+in+patients+with+advanced+malignancies+and+varying+degrees+of+renal+dysfunction%3A+a+study+by+the+National+Cancer+Institute+Organ+Dysfunction+Working+Group.&rft.au=Gibbons%2C+Joseph%3BEgorin%2C+Merrill+J%3BRamanathan%2C+Ramesh+K%3BFu%2C+Pingfu%3BMulkerin%2C+Daniel+L%3BShibata%2C+Stephen%3BTakimoto%2C+Chris+H+M%3BMani%2C+Sridhar%3BLoRusso%2C+Patricia+A%3BGrem%2C+Jean+L%3BPavlick%2C+Anna%3BLenz%2C+Heinz-Josef%3BFlick%2C+Susan+M%3BReynolds%2C+Sherrie%3BLagattuta%2C+Theodore+F%3BParise%2C+Robert+A%3BWang%2C+Yanfeng%3BMurgo%2C+Anthony+J%3BIvy%2C+S+Percy%3BRemick%2C+Scot+C%3BNational+Cancer+Institute+Organ+Dysfunction+Working+Group&rft.aulast=Gibbons&rft.aufirst=Joseph&rft.date=2008-02-01&rft.volume=26&rft.issue=4&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2007.13.3819 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2008-01-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Oncol. 2008 Sep 1;26(25):4226-7; author reply 4227-8 [18757345] J Clin Oncol. 2008 Feb 1;26(4):521-2 [18235112] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2007.13.3819 ER - TY - JOUR T1 - The HSA domain of BRG1 mediates critical interactions required for glucocorticoid receptor-dependent transcriptional activation in vivo. AN - 70243228; 18086889 AB - The packaging of eukaryotic DNA into chromatin can create an impediment to transcription by hindering binding of essential factors required for transcription. The mammalian SWI/SNF remodeling complex has been shown to alter local chromatin structure and facilitate recruitment of transcription factors. BRG1 (or hBrm), the central ATPase of the human SWI/SNF complex, is a critical factor for the functional activity of nuclear receptor complexes. Analysis using BRG1/SNF2h chimeras suggests BRG1 may contain previously uncharacterized functional motifs important for SWI/SNF. To identify these regions, BRG1 truncation and deletion mutants were designed, characterized, and utilized in a series of assays to evaluate transcriptional activation and chromatin remodeling by the glucocorticoid receptor. We identified a domain within the N terminus of BRG1 that mediates critical protein interactions within SWI/SNF. We find the HSA domain of BRG1 is required to mediate the interaction with BAF250a/ARID1A and show this association is necessary for transcriptional activation from chromatin mouse mammary tumor virus or endogenous promoters in vivo. These studies suggest BAF250a is a necessary facilitator of BRG1-mediated chromatin remodeling required for SWI/SNF-dependent transcriptional activation. JF - Molecular and cellular biology AU - Trotter, Kevin W AU - Fan, Hua-Ying AU - Ivey, Melissa L AU - Kingston, Robert E AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS/NIH, Research Triangle Park, NC 27709, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 1413 EP - 1426 VL - 28 IS - 4 KW - ARID1A protein, human KW - 0 KW - Chromosomal Proteins, Non-Histone KW - Mutant Proteins KW - Nuclear Proteins KW - Protein Subunits KW - Receptors, Glucocorticoid KW - SWI-SNF-B chromatin-remodeling complex KW - Transcription Factors KW - SMARCA4 protein, human KW - EC 3.6.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Animals KW - Humans KW - Mutant Proteins -- metabolism KW - Mammary Tumor Virus, Mouse KW - Mice KW - Chromosomal Proteins, Non-Histone -- metabolism KW - Protein Subunits -- metabolism KW - Protein Binding KW - Structure-Activity Relationship KW - Chromatin Assembly and Disassembly KW - Promoter Regions, Genetic -- genetics KW - Protein Structure, Tertiary KW - Sequence Deletion KW - DNA Helicases -- chemistry KW - DNA Helicases -- metabolism KW - Transcription Factors -- metabolism KW - Transcription Factors -- chemistry KW - Nuclear Proteins -- chemistry KW - Nuclear Proteins -- metabolism KW - Receptors, Glucocorticoid -- metabolism KW - Transcriptional Activation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70243228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=The+HSA+domain+of+BRG1+mediates+critical+interactions+required+for+glucocorticoid+receptor-dependent+transcriptional+activation+in+vivo.&rft.au=Trotter%2C+Kevin+W%3BFan%2C+Hua-Ying%3BIvey%2C+Melissa+L%3BKingston%2C+Robert+E%3BArcher%2C+Trevor+K&rft.aulast=Trotter&rft.aufirst=Kevin&rft.date=2008-02-01&rft.volume=28&rft.issue=4&rft.spage=1413&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2008-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2007 Feb 23;128(4):693-705 [17320507] Mol Cell Endocrinol. 2007 Feb;265-266:162-7 [17240047] Genes Dev. 2000 Oct 1;14(19):2441-51 [11018012] Mol Cell Biol. 2000 Dec;20(23):8879-88 [11073988] Hum Mol Genet. 2001 Nov 1;10(23):2651-60 [11726552] Genome Res. 2002 Jan;12(1):47-56 [11779830] Nature. 2001 Dec 20-27;414(6866):924-8 [11780067] Cell Growth Differ. 2002 Mar;13(3):95-106 [11959810] Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5919-24 [11959914] Biochem J. 2002 May 15;364(Pt 1):255-64 [11988099] Mol Endocrinol. 2002 Jun;16(6):1204-14 [12040008] EMBO J. 2002 Aug 1;21(15):4094-103 [12145209] Nat Cell Biol. 2002 Oct;4(10):774-81 [12244326] J Biol Chem. 2002 Nov 1;277(44):41674-85 [12200431] EMBO J. 2002 Nov 1;21(21):5797-806 [12411497] Mol Cell. 2003 May;11(5):1311-22 [12769854] Mol Cell Biol. 2003 Sep;23(17):6210-20 [12917342] J Biol Chem. 2003 Dec 12;278(50):49806-11 [14555651] Nucleic Acids Res. 2004;32(4):1345-53 [14982958] Mol Cell Biol. 2004 Apr;24(8):3347-58 [15060156] J Cell Sci. 2004 Aug 1;117(Pt 17):3707-11 [15286171] Biochem J. 2004 Oct 15;383(Pt 2):319-25 [15170388] Mol Cell Biol. 1991 Feb;11(2):688-98 [1846670] Mol Cell Biol. 1994 Jan;14(1):32-41 [8264599] Biochem J. 1994 Jan 15;297 ( Pt 2):249-60 [8297327] Mol Cell Biol. 1994 Apr;14(4):2225-34 [7908117] Mol Cell Biol. 1996 Apr;16(4):1576-83 [8657132] EMBO J. 1996 Oct 1;15(19):5370-82 [8895581] Gene. 1997 Mar 25;188(1):95-100 [9099865] Nature. 1997 Jun 12;387(6634):733-6 [9192902] Development. 1999 Mar;126(6):1175-87 [10021337] Mol Cell. 1999 Feb;3(2):247-53 [10078207] Biochim Biophys Acta. 2005 Jan 11;1681(2-3):59-73 [15627498] Mol Cell. 2005 Mar 18;17(6):805-15 [15780937] Genes Dev. 2005 Jul 15;19(14):1662-7 [15985610] Genes Dev. 2005 Dec 1;19(23):2849-61 [16287714] Mol Endocrinol. 2006 Jan;20(1):1-13 [16002433] Nat Rev Mol Cell Biol. 2006 Jun;7(6):437-47 [16723979] J Biol Chem. 2006 Aug 11;281(32):22656-64 [16769725] Methods Mol Biol. 1999;119:1-16 [10804500] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DSM-IV criteria endorsement patterns in alcohol dependence: relationship to severity. AN - 70241488; 18162067 AB - In DSM-IV, the diagnostic threshold for alcohol dependence (AD) is met when a patient presents with at least 3 of 7 criteria. We have computed the predictive value for each individual DSM-IV AD criterion, and examined subtypes of AD criteria endorsement patterns and their associated severity indicators for community-dwelling AD individuals. We utilized data from the 2001 to 2002 National Epidemiological Survey on Alcohol and Related Conditions (NESARC). Positive predictive values (PPV) for DSM-IV AD were computed for each of the individual criteria. Patterns of criteria endorsements were identified by latent class analysis (LCA). Sociodemographic status, age of onset and duration of AD, patterns of drinking, and drinking treatment history, were conditional on DSM criteria endorsement clusters, as indicators of the respondents' clinical severity. At the individual criterion level, the single criterion with the greatest PPV was D7--"Activities given up" with approximately 95% of drinking individuals who endorsed this DSM criterion correctly diagnosed as having DSM-IV AD. In addition to D7, only D5--"Physical/Psychological problems", and D6--"Time spent" had a PPV for AD substantially >50%. The LCA of AD endorsement patterns yielded a 6-cluster solution. The most common response pattern (34.5% of those with AD) was endorsement of 5 criteria: D1--"Quit/Control," D2--"Larger/Longer," D3--"Tolerance," D4--"Withdrawal," and D5--"Physical/Psychological problems." The most severe cluster (14%) was comprised of those who were likely to endorse 7/7 criteria. Cluster 1 (8.3%) did not include an endorsement of withdrawal, despite a heavy pattern of alcohol consumption. Unmarried status was associated with more severe criteria endorsement patterns. The present findings indicate a Guttman-like scaling of endorsement which yielded associations with severity for some of the concurrent indicators included in the analysis. However, severity measures did not always increase with DSM-IV AD criterion endorsement counts. Although endorsement of 6/7 or 7/7 criteria was associated with greater severity across a variety of indicators, fewer criteria were randomly associated with these measures. These data do not support the use of AD symptom counts as a phenotypic dependent variable. At least 2 extant diagnostic criteria showed relatively low PPV for AD, indicating a need for further assessment of these criteria with new symptoms or re-wording of the current symptom items. JF - Alcoholism, clinical and experimental research AU - Moss, Howard B AU - Chen, Chiung M AU - Yi, Hsiao-ye AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-9304, USA. mossh@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 306 EP - 313 VL - 32 IS - 2 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - United States KW - Alcohol-Related Disorders -- classification KW - Reproducibility of Results KW - Substance Withdrawal Syndrome -- diagnosis KW - Humans KW - Activities of Daily Living -- psychology KW - Substance Withdrawal Syndrome -- classification KW - Alcohol-Related Disorders -- diagnosis KW - Cross-Sectional Studies KW - Substance Withdrawal Syndrome -- epidemiology KW - Risk Factors KW - Adult KW - Health Surveys KW - Ethanol -- toxicity KW - Substance Withdrawal Syndrome -- psychology KW - Adolescent KW - Male KW - Alcohol-Related Disorders -- psychology KW - Female KW - Alcohol-Related Disorders -- epidemiology KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Alcoholism -- classification KW - Alcoholism -- psychology KW - Diagnostic and Statistical Manual of Mental Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70241488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=DSM-IV+criteria+endorsement+patterns+in+alcohol+dependence%3A+relationship+to+severity.&rft.au=Moss%2C+Howard+B%3BChen%2C+Chiung+M%3BYi%2C+Hsiao-ye&rft.aulast=Moss&rft.aufirst=Howard&rft.date=2008-02-01&rft.volume=32&rft.issue=2&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-26 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels. AN - 70241116; 18032571 AB - Large elevations in blood serotonin (5-hydroxytryptamine; 5-HT) can produce valvular heart disease in humans and laboratory animals. In accordance, one prevailing hypothesis (i.e., the "5-HT hypothesis") suggests that 5-HT transporter substrates like fenfluramine increase the risk for valvular heart disease by elevating plasma 5-HT, secondary to the release of 5-HT from platelets. The main purpose of this study was to determine whether chronic administration of fenfluramine increases plasma 5-HT to concentrations that are associated with the development of valvular heart disease. To the best of our knowledge, this is the first study to address this issue using an in vivo microdialysis method that measures plasma 5-HT in nonhypoxic rats. We examined the effects of chronic (+/-)-fenfluramine and fluoxetine on plasma levels of 5-HT and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in blood samples from conscious catheterized rats. Plasma indoles were measured by high-performance liquid chromatography with electrochemical detection in the dialysates of whole blood. The baseline plasma 5-HT level was <1.0 nM. Chronic fenfluramine (14-day minipump infusion) produced small increases in baseline plasma 5-HT ( approximately 2-4-fold), whereas chronic fluoxetine had no effect. Chronic fenfluramine and fluoxetine markedly decreased whole-blood 5-HT and reduced the ability of acute fenfluramine to evoke 5-HT release. Elevations in baseline plasma 5-HT produced by chronic fenfluramine are far below the micromolar levels necessary to produce valvular heart disease. Furthermore, chronic fenfluramine reduces the ability of acute fenfluramine to increase plasma 5-HT, suggesting that the 5-HT hypothesis cannot explain the increased risk of valvular heart disease in patients treated with fenfluramine. JF - The Journal of pharmacology and experimental therapeutics AU - Zolkowska, Dorota AU - Baumann, Michael H AU - Rothman, Richard B AD - Clinical Psychopharmacology, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Heath and Human Services, 5500 Nathan Shock Dr., Baltimore, MD 21224, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 791 EP - 797 VL - 324 IS - 2 KW - Fenfluramine KW - 2DS058H2CF KW - Serotonin KW - 333DO1RDJY KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Administration Schedule KW - Time Factors KW - Male KW - Fenfluramine -- administration & dosage KW - Serotonin -- blood KW - Drug-Related Side Effects and Adverse Reactions -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70241116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Chronic+fenfluramine+administration+increases+plasma+serotonin+%285-hydroxytryptamine%29+to+nontoxic+levels.&rft.au=Zolkowska%2C+Dorota%3BBaumann%2C+Michael+H%3BRothman%2C+Richard+B&rft.aulast=Zolkowska&rft.aufirst=Dorota&rft.date=2008-02-01&rft.volume=324&rft.issue=2&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2008-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety and tolerability of depot medroxyprogesterone acetate among HIV-infected women on antiretroviral therapy: ACTG A5093. AN - 70238750; 18226670 AB - Concomitant use of antiretroviral (ARV) and hormonal contraceptives may change the metabolism of each and the resulting safety profiles. We evaluated the safety and tolerability of depot medroxyprogesterone acetate (DMPA) among women on ARV. HIV-infected women on selected ARV regimens or no ARV were administered DMPA 150 mg intramuscularly and evaluated for 12 weeks for adverse events, changes in CD4+ count and HIV RNA levels, and ovulation. Seventy evaluable subjects were included, 16 on nucleoside only or no ARV, 21 on nelfinavir-containing regimens, 17 on efavirenz-containing regimens and 16 on nevirapine-containing regimens. Nine Grade 3 or 4 adverse events occurred in seven subjects; none were judged related to DMPA. The most common findings possibly related to DMPA were abnormal vaginal bleeding (nine, 12.7%), headache (three, 4.2%), abdominal pain, mood changes, insomnia, anorexia and fatigue, each occurring in two (2.9%) subjects. No significant changes in CD4+ count or HIV RNA levels occurred with DMPA. No evidence of ovulation was detected, and no pregnancies occurred. The clinical profile associated with DMPA administration in HIV-infected women, most on ARV, appears similar to that seen in HIV-uninfected women. DMPA prevented ovulation and did not affect CD4+ counts or HIV RNA levels. In concert with previously published DMPA/ARV interaction data, these data suggest that DMPA can be used safely by HIV-infected women on the ARV studied. JF - Contraception AU - Watts, D Heather AU - Park, Jeong-Gun AU - Cohn, Susan E AU - Yu, Song AU - Hitti, Jane AU - Stek, Alice AU - Clax, Pamela A AU - Muderspach, Laila AU - Lertora, Juan J L AD - National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. wattsh@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 84 EP - 90 VL - 77 IS - 2 SN - 0010-7824, 0010-7824 KW - Anti-HIV Agents KW - 0 KW - Benzoxazines KW - Contraceptive Agents, Female KW - RNA, Viral KW - Nevirapine KW - 99DK7FVK1H KW - Medroxyprogesterone Acetate KW - C2QI4IOI2G KW - Nelfinavir KW - HO3OGH5D7I KW - efavirenz KW - JE6H2O27P8 KW - Index Medicus KW - Nevirapine -- adverse effects KW - Drug Interactions KW - Nelfinavir -- administration & dosage KW - Humans KW - Safety KW - Injections, Intramuscular KW - Benzoxazines -- adverse effects KW - CD4 Lymphocyte Count KW - Viral Load KW - Nelfinavir -- adverse effects KW - Adult KW - Nevirapine -- administration & dosage KW - Benzoxazines -- administration & dosage KW - Female KW - RNA, Viral -- blood KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - Contraceptive Agents, Female -- adverse effects KW - Anti-HIV Agents -- adverse effects KW - Ovulation Inhibition -- drug effects KW - Contraceptive Agents, Female -- administration & dosage KW - Antiretroviral Therapy, Highly Active -- methods KW - Medroxyprogesterone Acetate -- administration & dosage KW - Medroxyprogesterone Acetate -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70238750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contraception&rft.atitle=Safety+and+tolerability+of+depot+medroxyprogesterone+acetate+among+HIV-infected+women+on+antiretroviral+therapy%3A+ACTG+A5093.&rft.au=Watts%2C+D+Heather%3BPark%2C+Jeong-Gun%3BCohn%2C+Susan+E%3BYu%2C+Song%3BHitti%2C+Jane%3BStek%2C+Alice%3BClax%2C+Pamela+A%3BMuderspach%2C+Laila%3BLertora%2C+Juan+J+L&rft.aulast=Watts&rft.aufirst=D&rft.date=2008-02-01&rft.volume=77&rft.issue=2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Contraception&rft.issn=00107824&rft_id=info:doi/10.1016%2Fj.contraception.2007.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-12 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Obes (Lond). 2005 Oct;29(10):1252-8 [15997247] Fertil Steril. 2004 Dec;82(6):1580-6 [15589863] Clin Pharmacol Ther. 2007 Feb;81(2):222-7 [17192768] Contraception. 1999 Dec;60(6):345-51 [10715369] AIDS. 2000 Oct 20;14(15):2355-60 [11089624] Contraception. 2001 Mar;63(3):143-6 [11368986] Epidemiology. 2002 Sep;13(5):581-7 [12192229] AIDS. 2003 Jul 25;17(11):1702-4 [12853757] J Infect Dis. 2004 Jan 15;189(2):303-11 [14722896] AIDS. 2004 Feb 20;18(3):475-83 [15090800] AIDS. 2004 Mar 5;18(4):695-7 [15090778] Fertil Steril. 1973 May;24(5):331-9 [4698589] Contraception. 1983 Jul;28(1):1-20 [6226488] Cytometry. 1993 Oct;14(7):702-15 [8243200] Bull World Health Organ. 1993;71(6):677-89 [8313486] Med J Aust. 1994 May 2;160(9):553-6 [8164553] Obstet Gynecol. 1996 Aug;88(2):227-33 [8692507] J Clin Microbiol. 1996 Nov;34(11):2695-701 [8897167] J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Apr 15;17(5):404-10 [9562042] Contraception. 1997 Nov;56(5):305-12 [9437559] Fam Plann Perspect. 1996 Nov-Dec;28(6):275-7 [8959418] Contraception. 1998 Apr;57(4):237-40 [9649914] J Acquir Immune Defic Syndr. 2006 Aug 15;42(5):562-71 [16837863] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.contraception.2007.10.002 ER - TY - JOUR T1 - Animal models for probing the developmental basis of disease and dysfunction paradigm. AN - 70237548; 18226058 AB - There is a major paradigm shift taking place in science that while simple is profound. The new paradigm suggests that susceptibility to disease is set in utero or neonatally as a result of the influences of nutrition and exposures to environmental stressors/toxicants. In utero nutrition and/or in utero or neonatal exposures to environmental toxicants alter susceptibility to disease later in life as a result of their ability to affect the programming of tissue function that occurs during development. This concept, which is still a hypothesis undergoing scientific testing and scrutiny, is called the developmental basis of health and disease. If true, then it says that the focus on disease prevention and intervention must change from the time of disease onset to perhaps decades prior: during the in utero and neonatal period. Perhaps the reason it has been so difficult to link environmental exposure to disease susceptibility is that scientists have been looking at the wrong time! Certainly, not all exposures that result in increased disease or dysfunction occur during development. This paradigm shift just suggests that this is a sensitive window of exposure that should be examined more thoroughly. This overview focuses on animal models for the assessment of this new scientific paradigm and the animal data that now supports it. JF - Basic & clinical pharmacology & toxicology AU - Heindel, Jerrold J AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. heindelj@niehs.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 76 EP - 81 VL - 102 IS - 2 KW - Environmental Pollutants KW - 0 KW - Phthalic Acids KW - Index Medicus KW - Gene Expression -- drug effects KW - Parkinson Disease, Secondary -- chemically induced KW - Animals KW - Environmental Pollutants -- toxicity KW - Adenocarcinoma -- chemically induced KW - Humans KW - Epigenesis, Genetic KW - Phthalic Acids -- toxicity KW - Pregnancy KW - Obesity -- etiology KW - Sperm Count KW - Neoplasms -- chemically induced KW - Leiomyoma -- chemically induced KW - Chronic Disease KW - Female KW - Fertility -- drug effects KW - Models, Animal KW - Maternal-Fetal Exchange KW - Environmental Exposure -- adverse effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70237548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Basic+%26+clinical+pharmacology+%26+toxicology&rft.atitle=Animal+models+for+probing+the+developmental+basis+of+disease+and+dysfunction+paradigm.&rft.au=Heindel%2C+Jerrold+J&rft.aulast=Heindel&rft.aufirst=Jerrold&rft.date=2008-02-01&rft.volume=102&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Basic+%26+clinical+pharmacology+%26+toxicology&rft.issn=1742-7843&rft_id=info:doi/10.1111%2Fj.1742-7843.2007.00184.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-22 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1742-7843.2007.00184.x ER - TY - JOUR T1 - Antifungal drugs and the risk of selected birth defects. AN - 70236799; 18226621 AB - This study examined whether first-trimester antifungal drug use was associated with the risk of selected birth defects. Subjects were participants in a case-control study, the National Birth Defects Prevention Study, with singleton deliveries from 1997 to 2003. Based on maternal interviews, first-trimester antifungal drug use was compared between 7047 cases with isolated defects and 4774 nonmalformed controls using unconditional logistic regression. Risk was elevated for hypoplastic left heart syndrome (odds ratio, 2.30; 95% confidence interval, 1.04, 5.06) but not for other cardiovascular defects. An increased risk of 1.88 was observed for diaphragmatic hernia but was not statistically significant. Estimates approximated unity for neural tube defects, oral clefts, anorectal atresia, hypospadias, and craniosynostosis. First-trimester antifungal drug exposure was not strongly associated with the risk of most birth defects, but further studies should examine the preliminary results of an association with hypoplastic left heart syndrome. JF - American journal of obstetrics and gynecology AU - Carter, Tonia C AU - Druschel, Charlotte M AU - Romitti, Paul A AU - Bell, Erin M AU - Werler, Martha M AU - Mitchell, Allen A AU - National Birth Defects Prevention Study AD - Department of Epidemiology, School of Public Health, State University of New York at Albany, Albany, USA. carterto@mail.nih.gov ; National Birth Defects Prevention Study Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 191.e1 EP - 7 VL - 198 IS - 2 KW - Antifungal Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Registries KW - Pregnancy Trimester, First KW - Risk Factors KW - Humans KW - Infant, Newborn KW - Case-Control Studies KW - United States -- epidemiology KW - Female KW - Pregnancy KW - Hypoplastic Left Heart Syndrome -- chemically induced KW - Abnormalities, Drug-Induced -- epidemiology KW - Antifungal Agents -- adverse effects KW - Heart Defects, Congenital -- epidemiology KW - Heart Defects, Congenital -- etiology KW - Candidiasis, Vulvovaginal -- drug therapy KW - Antifungal Agents -- administration & dosage KW - Abnormalities, Drug-Induced -- etiology KW - Pregnancy Complications, Infectious -- drug therapy KW - Hypoplastic Left Heart Syndrome -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70236799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Antifungal+drugs+and+the+risk+of+selected+birth+defects.&rft.au=Carter%2C+Tonia+C%3BDruschel%2C+Charlotte+M%3BRomitti%2C+Paul+A%3BBell%2C+Erin+M%3BWerler%2C+Martha+M%3BMitchell%2C+Allen+A%3BNational+Birth+Defects+Prevention+Study&rft.aulast=Carter&rft.aufirst=Tonia&rft.date=2008-02-01&rft.volume=198&rft.issue=2&rft.spage=191.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/10.1016%2Fj.ajog.2007.08.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ajog.2007.08.044 ER - TY - JOUR T1 - Molecular basis for agonist selectivity and activation of the orphan bombesin receptor subtype 3 receptor. AN - 70236064; 18006692 AB - Bombesin receptor subtype (BRS)-3, a G-protein-coupled orphan receptor, shares 51% identity with the mammalian bombesin (Bn) receptor for gastrin-releasing peptide. There is increasing interest in BRS-3 because it is important in energy metabolism, glucose control, motility, and tumor growth. BRS-3 has low affinity for all Bn-related peptides; however, recently synthetic high-affinity agonists, [d-Tyr(6)/d-Phe(6),betaAla(11),Phe(13),Nle(14)]Bn-(6-14), were described, but they are nonselective for BRS-3 over other Bn receptors. Based on these peptides, three BRS-3-selective ligands were developed: peptide 2, [d-Tyr(6)(R)-3-amino-propionic acid(11),Phe(13),Nle(14)]Bn(6-14); peptide 3, [d-Tyr(6),(R)-Apa(11),4Cl-Phe(13),Nle(14)]Bn(6-14); and peptide 4, acetyl-Phe-Trp-Ala-His-(tBzl)-piperidine-3 carboxylic acid-Gly-Arg-NH(2). Their molecular determinants of selectivity/high affinity for BRS-3 are unknown. To address this, we used a chimeric/site mutagenesis approach. Substitution of extracellular domain 2 (EC2) of BRS-3 by the comparable gastrin-releasing peptide receptor (GRPR) domain decreased 26-, 4-, and 0-fold affinity for peptides 4, 3, and 2. Substitution of EC3 decreased affinity 4-, 11-, and 0-fold affinity for peptides 2 to 4. Ten-point mutations in the EC2 and adjacent transmembrane regions (TM2) 2 and 3 of BRS-3 were made. His107 (EC2-BRS-3) for lysine (H107K) (EC2-GRPR) decreased affinity (25- and 0-fold) for peptides 4 and 1; however, it could not be activated by either peptide. Its combination with Val101 (TM2), Gly112 (EC2), and Arg127 (TM3) resulted in complete loss-of-affinity of peptide 4. Receptor-modeling showed that each of these residues face inward and are within 4 A of the binding pocket. These results demonstrate that Val101, His107, Gly112, and Arg127 in the EC2/adjacent upper TMs of BRS-3 are critical for the high BRS3 selectivity of peptide 4. His107 in EC2 is essential for BRS-3 activation, suggesting amino-aromatic ligand/receptor interactions with peptide 4 are critical for both binding and activation. Furthermore, these result demonstrate that even though these three BRS-3-selective agonists were developed from the same template peptide, [d-Phe(6),betaAla(11),Phe(13),Nle(14)]Bn-(6-14), their molecular determinants of selectivity/high affinity varied considerably. JF - The Journal of pharmacology and experimental therapeutics AU - Gonzalez, Nieves AU - Hocart, Simon J AU - Portal-Nuñez, Sergio AU - Mantey, Samuel A AU - Nakagawa, Tomoo AU - Zudaire, Enrique AU - Coy, David H AU - Jensen, Robert T AD - Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Heath, Building 10, Room 9C-103, 10 Center Dr. MSC 1804, Bethesda, MD 20892-1804, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 463 EP - 474 VL - 324 IS - 2 KW - Receptors, Bombesin KW - 0 KW - bombesin receptor subtype 3 KW - Bombesin KW - PX9AZU7QPK KW - Index Medicus KW - Bombesin -- analogs & derivatives KW - Animals KW - 3T3 Cells KW - Cattle KW - Cricetulus KW - Bombesin -- metabolism KW - Binding Sites -- drug effects KW - CHO Cells KW - Mice KW - Mice, Inbred BALB C KW - Binding Sites -- physiology KW - Cricetinae KW - Receptors, Bombesin -- agonists KW - Receptors, Bombesin -- metabolism KW - Receptors, Bombesin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70236064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Molecular+basis+for+agonist+selectivity+and+activation+of+the+orphan+bombesin+receptor+subtype+3+receptor.&rft.au=Gonzalez%2C+Nieves%3BHocart%2C+Simon+J%3BPortal-Nu%C3%B1ez%2C+Sergio%3BMantey%2C+Samuel+A%3BNakagawa%2C+Tomoo%3BZudaire%2C+Enrique%3BCoy%2C+David+H%3BJensen%2C+Robert+T&rft.aulast=Gonzalez&rft.aufirst=Nieves&rft.date=2008-02-01&rft.volume=324&rft.issue=2&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2008-01-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1997 Nov 13;390(6656):165-9 [9367152] J Biol Chem. 1997 Oct 10;272(41):26062-71 [9325344] Eur J Pharmacol. 1998 Feb 19;343(2-3):275-87 [9570477] J Biol Chem. 1998 May 29;273(22):13613-24 [9593699] J Biol Chem. 1998 Jun 26;273(26):15927-32 [9632639] Mol Pharmacol. 1998 Aug;54(2):364-71 [9687578] Biochemistry. 1999 Jul 20;38(29):9366-72 [10413511] Biochem Pharmacol. 2005 Feb 15;69(4):579-93 [15670577] J Pept Sci. 2005 Mar;11(3):136-41 [15635635] Cell Tissue Res. 2005 Apr;320(1):21-31 [15726424] J Comput Chem. 2005 Dec;26(16):1668-88 [16200636] Virchows Arch. 2006 Oct;449(4):421-7 [16967266] J Pharmacol Exp Ther. 2006 Nov;319(2):980-9 [16943256] Mol Pharmacol. 2006 Dec;70(6):1935-45 [16998007] Biochim Biophys Acta. 2007 Apr;1768(4):794-807 [17188232] Biochemistry. 2007 Apr 17;46(15):4522-31 [17381074] Pharmacol Rev. 2008 Mar;60(1):1-42 [18055507] J Pharmacol Exp Ther. 2000 Sep;294(3):1053-62 [10945859] J Mol Neurosci. 2000 Jun;14(3):137-46 [10984189] J Biol Chem. 2001 Jan 5;276(1):495-504 [11013243] J Biol Chem. 2001 Mar 23;276(12):9219-29 [11112777] J Biol Chem. 2001 Sep 28;276(39):36652-63 [11463790] Biochem Biophys Res Commun. 2004 Jun 4;318(3):698-703 [15144894] Genomics. 2004 Jul;84(1):139-46 [15203211] J Pharmacol Exp Ther. 2004 Sep;310(3):1161-70 [15102928] J Mol Biol. 2004 Sep 10;342(2):571-83 [15327956] J Biol Chem. 1993 Mar 15;268(8):5979-84 [8383682] Nature. 1993 Mar 25;362(6418):350-3 [8384323] J Biol Chem. 1993 Jul 15;268(20):14622-6 [8392057] Mol Pharmacol. 1994 Sep;46(3):495-501 [7935330] J Biol Chem. 1994 Dec 9;269(49):30953-9 [7983030] J Biol Chem. 1995 Jun 16;270(24):14394-8 [7782300] Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12436-40 [8618916] J Biol Chem. 1996 Jan 26;271(4):1950-6 [8567643] J Biol Chem. 1996 May 31;271(22):12795-800 [8662697] J Biol Chem. 1996 Dec 13;271(50):32016-20 [8943250] J Biol Chem. 1997 Jun 13;272(24):15154-60 [9182536] J Biol Chem. 1997 Jul 11;272(28):17405-9 [9211882] Mol Endocrinol. 1997 Dec;11(13):2048-53 [9415408] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nitric oxide reacts with methoxide. AN - 70235876; 18184006 AB - Despite over a century of reports to the contrary, sodium methoxide has been found to react with nitric oxide (NO). The reaction, whose final organic product is sodium formate, is postulated to occur via an intermediate O-bound diazeniumdiolate [CH3O-N(O)=NO-] that decomposes to formaldehyde and nitrous oxide. Sodium formate forms from the aldehyde via a Cannizzaro reaction. Carboxylate salts have similarly been obtained by exposing sodium benzylate and sodium neopentoxide to NO in dioxane solution. Accordingly, sodium trimethylsilanoate should be considered as a substitute for sodium methoxide as the base used to accomplish the replacement of active hydrogens by the diazeniumdiolate functional group via the Traube reaction. JF - The Journal of organic chemistry AU - Derosa, Frank AU - Keefer, Larry K AU - Hrabie, Joseph A AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 1139 EP - 1142 VL - 73 IS - 3 SN - 0022-3263, 0022-3263 KW - sodium ethoxide KW - 141-52-6 KW - Nitric Oxide KW - 31C4KY9ESH KW - Ethanol KW - 3K9958V90M KW - Sodium Benzoate KW - OJ245FE5EU KW - Methanol KW - Y4S76JWI15 KW - Index Medicus KW - Molecular Structure KW - Sodium Benzoate -- chemistry KW - Ethanol -- analogs & derivatives KW - Ethanol -- chemistry KW - Nitric Oxide -- chemistry KW - Methanol -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70235876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+organic+chemistry&rft.atitle=Nitric+oxide+reacts+with+methoxide.&rft.au=Derosa%2C+Frank%3BKeefer%2C+Larry+K%3BHrabie%2C+Joseph+A&rft.aulast=Derosa&rft.aufirst=Frank&rft.date=2008-02-01&rft.volume=73&rft.issue=3&rft.spage=1139&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+organic+chemistry&rft.issn=00223263&rft_id=info:doi/10.1021%2Fjo7020423 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-03 N1 - Date created - 2008-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jo7020423 ER - TY - JOUR T1 - Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone. AN - 70235410; 17974624 AB - Although estrogen has effects on the heart, little is known regarding which genes in the heart are directly responsive to estrogen. We have shown previously that lipoprotein lipase (LPL) expression was increased in female hearts compared with male hearts. To test whether LPL gene expression in heart is regulated by estrogen, we perfused mouse hearts from ovariectomized females with 100 nM 17beta-estradiol or vehicle for 2 h, after which hearts were frozen, and RNA was isolated. The SYBR green real-time PCR method was used to detect LPL gene expression. We found that addition of 17beta-estradiol to hearts from ovariectomized females resulted in a significant increase in LPL mRNA. This estrogen effect on LPL gene expression in mouse heart can be blocked by the estrogen receptor (ER) antagonist ICI 182,780 or by progesterone. We also identified a potential estrogen receptor element (ERE) enhancer sequence located in the first intron of the mouse LPL gene. The potential ERE sequence was linked to a TATA-luciferase (LUC) reporter plasmid in HeLa cells. Both ERalpha and ERbeta stimulated strong activity on the heterologous promoter reporter in Hela cells upon estrogen addition. Both ERalpha and ERbeta activities on the LPL ERE reporter were abrogated by the ER antagonist ICI 182,780. Progesterone also dose dependently inhibited the estrogen-mediated increase in LPL ERE reporter activity. These results show that heart LPL is an estrogen-responsive gene exhibiting an intronic regulatory sequence. JF - Endocrinology AU - Liu, Dianxin AU - Deschamps, Anne AU - Korach, Kenneth S AU - Murphy, Elizabeth AD - Laboratories of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 711 EP - 716 VL - 149 IS - 2 SN - 0013-7227, 0013-7227 KW - RNA, Messenger KW - 0 KW - Progesterone KW - 4G7DS2Q64Y KW - Estradiol KW - 4TI98Z838E KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Drug Interactions KW - Introns -- physiology KW - RNA, Messenger -- metabolism KW - HeLa Cells KW - Dose-Response Relationship, Drug KW - Humans KW - Mice, Inbred C57BL KW - Genes, Reporter KW - Ovariectomy KW - Mice KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Progesterone -- pharmacology KW - Lipoprotein Lipase -- genetics KW - Gene Expression Regulation, Enzymologic -- physiology KW - Myocardium -- enzymology KW - Estradiol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70235410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Estrogen-enhanced+gene+expression+of+lipoprotein+lipase+in+heart+is+antagonized+by+progesterone.&rft.au=Liu%2C+Dianxin%3BDeschamps%2C+Anne%3BKorach%2C+Kenneth+S%3BMurphy%2C+Elizabeth&rft.aulast=Liu&rft.aufirst=Dianxin&rft.date=2008-02-01&rft.volume=149&rft.issue=2&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Cell Cardiol. 2005 Feb;38(2):289-97 [15698835] Lipids. 1994 May;29(5):333-6 [8015363] J Biol Chem. 2006 Mar 31;281(13):8716-23 [16410253] FASEB J. 2006 May;20(7):926-34 [16675850] J Biol Chem. 2006 Sep 8;281(36):26683-92 [16847062] Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R800-9 [17008461] J Mol Endocrinol. 2000 Feb;24(1):145-55 [10657006] Circulation. 2001 Sep 18;104(12):1419-23 [11560859] FEBS Lett. 2001 Aug 3;502(3):103-8 [11583108] Am Heart J. 1996 Aug;132(2 Pt 1):258-62 [8701884] Circulation. 1997 Jan 7;95(1):252-64 [8994444] Circ Res. 1998 Dec 14-28;83(12):1215-23 [9851938] Mol Endocrinol. 1999 Mar;13(3):485-94 [10077005] Circulation. 2004 Nov 16;110(20):3270-5 [15533858] Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H469-76 [15374829] JAMA. 2002 Jul 17;288(3):321-33 [12117397] Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E331-9 [12388125] J Clin Invest. 2003 Feb;111(3):419-26 [12569168] Metabolism. 2003 Apr;52(4):383-8 [12701046] J Pharmacol Exp Ther. 2003 Oct;307(1):395-401 [12893838] Hypertension. 2003 Oct;42(4):781-6 [12874087] Atherosclerosis. 2003 Dec;171(2):343-50 [14644406] J Biol Chem. 2004 Jun 11;279(24):25050-7 [15028738] Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14234-9 [15375213] Biochim Biophys Acta. 1993 Aug 11;1169(2):107-25 [8343535] Circulation. 2005 Mar 29;111(12):1492-8 [15781739] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1. AN - 70235304; 18220474 AB - ICBP90/UHRF1, which is overexpressed in cancer cells and is down-regulated by p53, possesses a methylated CpG binding affinity and binds to the methylated promoters of tumor suppressor genes in cancer cells with HDAC1 and DNMT1, suggesting suppression of these genes and maintenance of methylation status which leads to carcinogenesis. Recently, it was reported that the human homolog of Np95 is different from ICBP90 but not from UHRF1. Because UHRF1 is the gene symbol of ICBP90, the claim is a little confusing; that is, UHRF1 and ICBP90 are identical. Because the previously published genomic structure of the ICBP90 gene needed to be revised and the registered ICBP90 sequence (AF129507) contains two rare polymorphisms or sequence errors, we think that confusion could occur. Here we show the revised ICBP90 gene structure and 366 polymorphisms in this gene. Our conclusion is that the human homolog of Np95 is ICBP90, whose gene symbol is UHRF1. JF - Radiation research AU - Unoki, Motoko AU - Bronner, Christian AU - Mousli, Marc AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4258, USA. unokim@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 240 EP - 244 VL - 169 IS - 2 SN - 0033-7587, 0033-7587 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - Nuclear Proteins KW - Protein Isoforms KW - UHRF1 protein, human KW - Uhrf1 protein, mouse KW - Index Medicus KW - Space life sciences KW - Animals KW - Conserved Sequence -- genetics KW - Base Sequence KW - Sequence Homology, Nucleic Acid KW - Humans KW - Molecular Sequence Data KW - Mice KW - Protein Isoforms -- genetics KW - Species Specificity KW - Nuclear Proteins -- genetics KW - CCAAT-Enhancer-Binding Proteins -- genetics KW - Chromosome Mapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70235304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=A+concern+regarding+the+current+confusion+with+the+human+homolog+of+mouse+Np95%2C+ICBP90%2FUHRF1.&rft.au=Unoki%2C+Motoko%3BBronner%2C+Christian%3BMousli%2C+Marc&rft.aulast=Unoki&rft.aufirst=Motoko&rft.date=2008-02-01&rft.volume=169&rft.issue=2&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1209.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-28 N1 - Date created - 2008-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1667/RR1209.1 ER - TY - JOUR T1 - A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. AN - 70213230; 18032517 AB - A key function of the Nef protein of immunodeficiency viruses is the downregulation of the T-cell and macrophage coreceptor, CD4, from the surfaces of infected cells. CD4 downregulation depends on a conserved (D/E)XXXL(L/I)-type dileucine motif in the C-terminal, flexible loop of Nef, which mediates binding to the clathrin adaptor complexes AP-1, AP-2, and AP-3. We now report the identification of a consensus (D/E)D motif within this loop as a second, conserved determinant of interaction of Nef with AP-2, though not with AP-1 and AP-3. Mutations in this diacidic motif abrogate both AP-2 binding and CD4 downregulation. We also show that a dileucine motif from tyrosinase, both in its native context and in the context of Nef, can bind to AP-2 independently of a diacidic motif. These results thus identify a novel type of AP-2 interaction determinant, support the notion that AP-2 is the key clathrin adaptor for the downregulation of CD4 by Nef, and reveal a previously unrecognized diversity among dileucine sorting signals. JF - Journal of virology AU - Lindwasser, O Wolf AU - Smith, William J AU - Chaudhuri, Rittik AU - Yang, Peter AU - Hurley, James H AU - Bonifacino, Juan S AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T, Room 101, National Institutes of Health, Bethesda, MD 20892, USA. juan@helix.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 1166 EP - 1174 VL - 82 IS - 3 KW - Adaptor Protein Complex 1 KW - 0 KW - Adaptor Protein Complex 2 KW - Adaptor Protein Complex 3 KW - Mutant Proteins KW - nef Gene Products, Human Immunodeficiency Virus KW - nef protein, Human immunodeficiency virus 1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Adaptor Protein Complex 3 -- metabolism KW - Models, Molecular KW - HeLa Cells KW - Mutant Proteins -- metabolism KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Binding KW - Adaptor Protein Complex 1 -- metabolism KW - nef Gene Products, Human Immunodeficiency Virus -- genetics KW - HIV-1 -- physiology KW - nef Gene Products, Human Immunodeficiency Virus -- metabolism KW - nef Gene Products, Human Immunodeficiency Virus -- chemistry KW - Protein Interaction Domains and Motifs KW - Adaptor Protein Complex 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70213230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=A+diacidic+motif+in+human+immunodeficiency+virus+type+1+Nef+is+a+novel+determinant+of+binding+to+AP-2.&rft.au=Lindwasser%2C+O+Wolf%3BSmith%2C+William+J%3BChaudhuri%2C+Rittik%3BYang%2C+Peter%3BHurley%2C+James+H%3BBonifacino%2C+Juan+S&rft.aulast=Lindwasser&rft.aufirst=O&rft.date=2008-02-01&rft.volume=82&rft.issue=3&rft.spage=1166&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Biol. 1998 Nov 5;8(22):1239-42 [9811611] Curr Biol. 1998 Nov 5;8(22):1235-8 [9811606] J Mol Biol. 1999 May 28;289(1):123-38 [10339411] J Cell Biol. 2004 Dec 6;167(5):903-13 [15569716] J Virol. 2005 Feb;79(4):2066-78 [15681409] J Biol Chem. 2005 Mar 4;280(9):7413-26 [15611114] J Biol Chem. 2005 Apr 1;280(13):12840-8 [15653685] J Virol. 2005 Sep;79(17):11422-33 [16103193] J Immunol. 2005 Sep 1;175(5):3157-64 [16116206] Mol Biol Cell. 2005 Nov;16(11):5356-72 [16162817] J Virol. 2006 Feb;80(3):1311-20 [16415008] J Virol. 2006 Feb;80(4):1837-49 [16439540] Microbiol Mol Biol Rev. 2006 Jun;70(2):548-63 [16760313] Traffic. 2007 Jan;8(1):61-76 [17140399] Curr Mol Med. 2007 Mar;7(2):171-84 [17346169] J Virol. 2007 Apr;81(8):3877-90 [17267500] Mol Biol Cell. 2007 May;18(5):1887-96 [17360967] Mol Cell. 2007 May 11;26(3):403-14 [17499046] Mol Biol Cell. 2007 Sep;18(9):3351-65 [17581864] Microbes Infect. 2002 Feb;4(2):189-99 [11880052] J Biol Chem. 2002 Aug 9;277(32):28521-9 [12032142] J Virol. 2003 Feb;77(3):2124-33 [12525647] J Biol Chem. 2003 Mar 7;278(10):8725-32 [12486136] Annu Rev Biochem. 2003;72:395-447 [12651740] J Cell Biol. 2003 Dec 22;163(6):1281-90 [14691137] Mol Cell. 2004 Jan 30;13(2):179-90 [14759364] Curr HIV Res. 2003 Apr;1(2):167-84 [15043201] Curr HIV Res. 2004 Jan;2(1):51-9 [15053340] Trends Cell Biol. 2004 Apr;14(4):167-74 [15066634] Annu Rev Cell Dev Biol. 2004;20:153-91 [15473838] Nature. 1991 Apr 11;350(6318):508-11 [2014052] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10915-9 [1438297] J Virol. 1993 Aug;67(8):4639-50 [8043040] Cell. 1994 Mar 11;76(5):853-64 [8124721] J Virol. 1994 Aug;68(8):5156-63 [8035515] J Mol Biol. 1994 Aug 12;241(2):136-42 [8057354] J Virol. 1995 Mar;69(3):1510-20 [7853484] EMBO J. 1995 Oct 16;14(20):4961-75 [7588625] Virology. 1996 Mar 1;217(1):293-300 [8599214] Virology. 1996 Mar 1;217(1):397-403 [8599229] Nat Struct Biol. 1996 Apr;3(4):340-5 [8599760] Cell. 1996 Jun 14;85(6):931-42 [8681387] Biochemistry. 1996 Aug 13;35(32):10256-61 [8756680] J Virol. 1996 Nov;70(11):7752-64 [8892896] EMBO J. 1997 Feb 17;16(4):673-84 [9049297] Immunity. 1997 Jan;6(1):67-77 [9052838] Protein Sci. 1997 Jun;6(6):1248-63 [9194185] J Cell Biol. 1997 Oct 6;139(1):37-47 [9314527] EMBO J. 1997 Dec 1;16(23):6964-76 [9384576] Immunity. 1998 Apr;8(4):483-95 [9586638] EMBO J. 1998 May 15;17(10):2777-89 [9582271] Immunity. 1998 May;8(5):647-56 [9620685] J Biol Chem. 1998 Jun 19;273(25):15727-33 [9624170] Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11229-34 [9736718] J Virol. 1999 Mar;73(3):1964-73 [9971776] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The usefulness of the detection of GSTP1 methylation in urine as a biomarker in the diagnosis of prostate cancer. AN - 70211218; 18076912 AB - Prostate cancer has a unique set of problems associated with its early detection and diagnosis that might be aided by the addition of molecular markers, such as DNA hypermethylation. DNA methylation is an important epigenetic mechanism of gene regulation that has a critical role in normal developmental processes. Aberrant DNA methylation is a hallmark of carcinogenesis and GSTP1 hypermethylation is the most common molecular alteration in human prostate cancer. To our knowledge the clinical usefulness of the detection of gene methylation is yet to be established. We evaluated GSTP1 hypermethylation in urine collected after prostatic massage and in core needle biopsies from 100 men referred for diagnostic biopsy. Methylation of GSTP1 in urine specimens had 75% sensitivity and 98% specificity for prostate cancer. GSTP1 methylation in the biopsy had 88% specificity and 91% sensitivity. Interestingly we observed a higher frequency of GSTP1 methylation in the urine of men with stage III vs II disease (100% vs 20%, p = 0.05). This study suggests that the detection of GSTP1 methylation in prediagnostic urine may improve the specificity of PSA and help distinguish men with prostate cancer from those with benign prostatic hyperplasia. This finding should be further explored in a larger, prospective screening trial. JF - The Journal of urology AU - Woodson, Karen AU - O'Reilly, Keith J AU - Hanson, Jeffrey C AU - Nelson, Dayne AU - Walk, Elyse L AU - Tangrea, Joseph A AD - Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 508 EP - 11; discussion 511-2 VL - 179 IS - 2 KW - Biomarkers, Tumor KW - 0 KW - GSTP1 protein, human KW - EC 2.5.1.18 KW - Glutathione S-Transferase pi KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Polymerase Chain Reaction KW - Neoplasm Staging KW - Humans KW - Prostate-Specific Antigen -- blood KW - Aged KW - Middle Aged KW - Male KW - Prostatic Neoplasms -- metabolism KW - Glutathione S-Transferase pi -- genetics KW - Prostatic Neoplasms -- diagnosis KW - DNA Methylation KW - Biomarkers, Tumor -- urine KW - Glutathione S-Transferase pi -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70211218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=The+usefulness+of+the+detection+of+GSTP1+methylation+in+urine+as+a+biomarker+in+the+diagnosis+of+prostate+cancer.&rft.au=Woodson%2C+Karen%3BO%27Reilly%2C+Keith+J%3BHanson%2C+Jeffrey+C%3BNelson%2C+Dayne%3BWalk%2C+Elyse+L%3BTangrea%2C+Joseph+A&rft.aulast=Woodson&rft.aufirst=Karen&rft.date=2008-02-01&rft.volume=179&rft.issue=2&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=1527-3792&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupation and breast cancer risk among Shanghai women in a population-based cohort study. AN - 70209855; 18067183 AB - A total of 74,942 female subjects were recruited in a population-based cohort study in Shanghai, China between 1997 and 2000. We examined the relationship between occupation and breast cancer risk. Cases were 586 women previously diagnosed with breast cancer at baseline and 438 women newly diagnosed with breast cancer during follow-up through December 2004. Eight controls were randomly selected for each case from cancer-free cohort members and frequency-matched to the cases by year of birth and age at diagnosis. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of breast cancer risk associated with occupations, adjusting for established breast cancer risk factors. In the prevalent breast cancer data analysis, increased risks of breast cancer were associated with technicians in engineering/agriculture/forestry (OR = 1.6, CI: 1.0-2.4), teaching personnel (OR = 1.5, CI:1.1-2.0), tailoring/sewing workers (OR = 1.6, CI:1.0-2.7), and examiners/measurers/testers (OR = 1.5, CI:1.1-2.1) among those who started the jobs at least 20 years ago. Among incident breast cancer cases, significantly increased risks were associated with medical/health care workers (OR = 1.4, CI:1.0-2.0), administrative clerical workers (OR = 1.5, CI:1.0-2.4), postal/telecommunication workers (OR = 2.2, CI:1.0-5.5), and odd-job workers (OR = 1.7, CI:1.1-2.8) among those who started the jobs at least 20 years ago. The excess risks were found in both prevalent and incident cases for postal/telecommunication workers and purchasing/marketing personnel, although ORs reached only marginal significance. This study suggests that white-collar professionals and several production occupations may be associated with an increased risk of breast cancer. JF - American journal of industrial medicine AU - Ji, Bu-Tian AU - Blair, Aaron AU - Shu, Xiao-Ou AU - Chow, Wong-Ho AU - Hauptmann, Michael AU - Dosemeci, Mustafa AU - Yang, Gong AU - Lubin, Jay AU - Gao, Yu-Tang AU - Rothman, Nathaniel AU - Zheng, Wei AD - National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA. jib@exchange.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 100 EP - 110 VL - 51 IS - 2 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Women's Health KW - Humans KW - Aged KW - Risk Assessment KW - China -- epidemiology KW - Risk Factors KW - Adult KW - Health Surveys KW - Surveys and Questionnaires KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Female KW - Prevalence KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Breast Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70209855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Occupation+and+breast+cancer+risk+among+Shanghai+women+in+a+population-based+cohort+study.&rft.au=Ji%2C+Bu-Tian%3BBlair%2C+Aaron%3BShu%2C+Xiao-Ou%3BChow%2C+Wong-Ho%3BHauptmann%2C+Michael%3BDosemeci%2C+Mustafa%3BYang%2C+Gong%3BLubin%2C+Jay%3BGao%2C+Yu-Tang%3BRothman%2C+Nathaniel%3BZheng%2C+Wei&rft.aulast=Ji&rft.aufirst=Bu-Tian&rft.date=2008-02-01&rft.volume=51&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-14 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bioelectromagnetics. 2001;Suppl 5:S105-19 [11170121] Ann Epidemiol. 2000 Jan;10(1):31-44 [10658687] Am J Ind Med. 2001 Nov;40(5):596-603 [11675630] Environ Mol Mutagen. 2002;39(2-3):150-7 [11921183] Am J Ind Med. 2002 Oct;42(4):296-308 [12271477] Am J Epidemiol. 2003 Jul 1;158(1):47-58 [12835286] Cancer Causes Control. 2003 Sep;14(7):627-37 [14575360] Am J Epidemiol. 2003 Nov 15;158(10):969-80 [14607805] Am J Ind Med. 2003 Dec;44(6):643-52 [14635241] Am J Epidemiol. 2004 May 1;159(9):852-61 [15105178] J Occup Med. 1978 Jun;20(6):409-13 [671118] Lancet. 1978 Oct 14;2(8094):814-6 [81365] Am J Public Health. 1979 May;69(5):508-11 [434285] Environ Health Perspect. 1981 Oct;41:137-43 [6977443] J Occup Med. 1983 Oct;25(10):760-2 [6631561] Br Med J (Clin Res Ed). 1985 Jul 20;291(6489):194-6 [3926119] J Occup Med. 1987 Jun;29(6):535-41 [3612328] West J Med. 1988 Dec;149(6):734-40 [3074573] Br J Ind Med. 1990 Mar;47(3):162-8 [2328223] Cancer Causes Control. 1992 Jul;3(4):299-307 [1617116] Int J Cancer. 1993 Mar 12;53(5):764-70 [8449600] Cancer Causes Control. 1993 Jul;4(4):355-60 [8347785] Cancer Causes Control. 1994 Jan;5(1):31-7 [8123777] J Natl Cancer Inst. 1994 Jun 15;86(12):921-5 [8196082] Cancer Causes Control. 1994 Sep;5(5):449-57 [7999967] J Occup Med. 1994 Aug;36(8):867-74 [7807267] J Occup Med. 1994 Nov;36(11):1174-9 [7861260] J Occup Med. 1994 Nov;36(11):1204-9 [7861264] J Occup Environ Med. 1995 Mar;37(3):328-35 [7796201] J Occup Environ Med. 1995 Mar;37(3):336-48 [7796202] Occup Environ Med. 1996 Mar;53(3):145-56 [8704854] Environ Health Perspect. 1996 Mar;104 Suppl 1:135-40 [8722117] Am J Ind Med. 1997 Jul;32(1):1-14 [9131206] Occup Environ Med. 1998 Jan;55(1):43-8 [9536162] Am J Ind Med. 1998 Nov;34(5):477-83 [9787852] J Occup Environ Med. 2000 Mar;42(3):284-310 [10738708] Int J Epidemiol. 2005 Apr;34(2):405-12 [15737977] Eur J Cancer. 2005 Sep;41(13):2023-32 [16084719] Am J Epidemiol. 2005 Dec 1;162(11):1123-31 [16236996] J Pineal Res. 1999 Mar;26(2):65-100 [10100735] Am J Public Health. 1999 Jun;89(6):875-81 [10358678] Am J Ind Med. 1999 Jul;36(1):135-41 [10361598] Am J Ind Med. 1999 Jul;36(1):172-85 [10361604] Int J Cancer. 1999 Sep 24;83(1):18-29 [10449602] Am J Epidemiol. 2005 Jan 15;161(2):121-35 [15632262] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Ann Epidemiol. 2001 Jul;11(5):297-303 [11399443] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues. AN - 70207560; 18024160 AB - Imaging studies have shown an association between dopamine increases in striatum and cue induced craving in cocaine abusers. However, the extent to which dopamine increases reflect a primary rather than a secondary response to the cues remains unclear. Here we evaluated the extent to which dopamine increases by themselves can induce craving in cocaine abusers. Using PET and [(11)C]raclopride (D2 receptor radioligand sensitive to competition with endogenous dopamine) we show that in cocaine abusers (n=20) oral methylphenidate (20 mg), which significantly increased dopamine in striatum, did not induce craving unless subjects were concomitantly exposed to cocaine cues (video scenes of subjects self-administering cocaine). This suggests that dopamine increases associated with conditioned cues are not primary responses but reflect downstream stimulation of dopamine cells (presumably glutamatergic afferents from prefrontal cortex and/or amygdala). Inasmuch as afferent stimulation of dopamine neurons results in phasic cell firing these findings suggest that "fast" dopamine increases, in contrast to the "slow" dopamine increases as achieved when using oral methylphenidate (mimicking tonic dopamine cell firing), are required for cues to trigger craving. The fact that methylphenidate induced craving only when given with the cocaine cues highlights the context dependency of methylphenidate's effects and suggests that its use for the treatment of ADHD subjects with co-morbid drug abuse should not increase craving. JF - NeuroImage AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Telang, Frank AU - Fowler, Joanna S AU - Logan, Jean AU - Childress, Anna-Rose AU - Jayne, Millard AU - Ma, Yeming AU - Wong, Christopher AD - National Institute on Drug Abuse, Bethesda MD 20892, USA; National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 1266 EP - 1273 VL - 39 IS - 3 SN - 1053-8119, 1053-8119 KW - Dopamine Antagonists KW - 0 KW - Dopamine Uptake Inhibitors KW - Methylphenidate KW - 207ZZ9QZ49 KW - Raclopride KW - 430K3SOZ7G KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Positron-Emission Tomography KW - Methylphenidate -- pharmacology KW - Brain Chemistry -- drug effects KW - Humans KW - Heart Rate -- drug effects KW - Adult KW - Brain -- anatomy & histology KW - Surveys and Questionnaires KW - Tomography KW - Middle Aged KW - Blood Pressure -- drug effects KW - Image Processing, Computer-Assisted KW - Female KW - Male KW - Dopamine Uptake Inhibitors -- pharmacology KW - Neostriatum -- metabolism KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Dopamine -- metabolism KW - Neostriatum -- diagnostic imaging KW - Cocaine-Related Disorders -- metabolism KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70207560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Dopamine+increases+in+striatum+do+not+elicit+craving+in+cocaine+abusers+unless+they+are+coupled+with+cocaine+cues.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BTelang%2C+Frank%3BFowler%2C+Joanna+S%3BLogan%2C+Jean%3BChildress%2C+Anna-Rose%3BJayne%2C+Millard%3BMa%2C+Yeming%3BWong%2C+Christopher&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2008-02-01&rft.volume=39&rft.issue=3&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-01-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Synapse. 2002 Jun 1;44(3):175-80 [11954049] J Neurosci. 2007 May 23;27(21):5730-43 [17522317] Eur J Pharmacol. 2002 Jun 20;446(1-3):111-8 [12098592] Exp Clin Psychopharmacol. 2002 Aug;10(3):286-94 [12233989] Physiol Behav. 2002 Dec;77(4-5):513-7 [12526992] Nature. 2003 Apr 10;422(6932):614-8 [12687000] Psychopharmacology (Berl). 2003 Jul;168(1-2):44-56 [12652346] Am J Psychiatry. 2003 Nov;160(11):1909-18 [14594733] J Neurosci. 2004 Feb 18;24(7):1551-60 [14973230] Am J Psychiatry. 2004 Jul;161(7):1173-80 [15229048] J Neurosci. 2004 Aug 11;24(32):7167-73 [15306650] Am J Drug Alcohol Abuse. 1985;11(3-4):193-7 [4091158] Brain Res. 1988 Oct 11;462(1):194-8 [3179734] Annu Rev Psychol. 1989;40:191-225 [2648975] J Cereb Blood Flow Metab. 1990 Sep;10(5):740-7 [2384545] Am J Psychiatry. 1991 May;148(5):621-6 [2018164] Neuroscience. 1992;48(3):621-9 [1603333] J Nucl Med. 1993 Apr;34(4):609-13 [8455077] Neurosci Lett. 1993 Jul 9;157(1):53-6 [7901810] Drug Alcohol Depend. 1993 Dec;34(1):19-28 [8174499] Synapse. 1994 Apr;16(4):255-62 [8059335] J Cereb Blood Flow Metab. 1994 Nov;14(6):995-1010 [7929663] Arch Gen Psychiatry. 1995 Jun;52(6):456-63 [7771915] Psychopharmacology (Berl). 1995 Jul;120(1):10-20 [7480530] Neurosci Lett. 1996 Jun 21;211(2):73-6 [8830847] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12040-5 [8876259] Psychopharmacology (Berl). 1996 Aug;126(4):331-8 [8878349] Science. 1997 Mar 14;275(5306):1593-9 [9054347] Nature. 1997 Apr 24;386(6627):830-3 [9126741] Neuron. 1997 Sep;19(3):591-611 [9331351] Am J Psychiatry. 1998 Jan;155(1):124-6 [9433350] J Psychopharmacol. 1998;12(1):15-22 [9584964] Am J Psychiatry. 1999 Jan;156(1):11-8 [9892292] Am J Psychiatry. 1999 Jan;156(1):19-26 [9892293] Synapse. 1999 Jan;31(1):59-66 [10025684] Life Sci. 1999;64(9):775-84 [10075110] Int Rev Neurobiol. 2005;63:1-20 [15797463] J Neurosci. 2005 Apr 13;25(15):3932-9 [15829645] Neuropsychopharmacology. 2005 May;30(5):853-63 [15549053] Am J Psychiatry. 2005 Aug;162(8):1403-13 [16055761] J Neurosci. 2005 Sep 21;25(38):8665-70 [16177034] Drug Alcohol Depend. 2006 Apr 28;82(2):158-67 [16213109] Brain Res Bull. 2000 Jan 1;51(1):89-93 [10654586] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4321-6 [10760299] J Neurosci. 2000 May 15;20(10):3874-83 [10804227] Am J Psychiatry. 2000 Nov;157(11):1789-98 [11058476] Behav Neurosci. 2000 Dec;114(6):1156-66 [11142647] Arch Gen Psychiatry. 2001 Apr;58(4):334-41 [11296093] J Neurosci. 2001 Aug 15;21(16):RC160 [11473131] Synapse. 2002 Mar 1;43(3):181-7 [11793423] Neuropsychopharmacology. 2002 Mar;26(3):376-86 [11850152] J Neurosci. 2006 Jun 14;26(24):6583-8 [16775146] Neuropsychopharmacology. 2006 Jul;31(7):1362-70 [16319913] Neuron. 2006 Sep 7;51(5):541-7 [16950153] Neuropsychopharmacology. 2006 Dec;31(12):2716-27 [16971900] Am J Psychiatry. 2007 Apr;164(4):622-9 [17403976] Trends Neurosci. 2007 May;30(5):220-7 [17400299] J Neurosci. 2002 Jun 15;22(12):5173-87 [12077212] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 5-HT 1B receptor-mediated serotoninergic modulation of methylphenidate-induced locomotor activation in rats. AN - 70202533; 17487226 AB - Previous studies have shown that the dopamine (DA) uptake blocker methylphenidate, a psychostimulant widely used for the treatment of attention-deficit hyperactivity disorder (ADHD), prevents the neurotoxic effects of the highly abused DA releaser methamphetamine. However, there is a lack of information about the pharmacological interactions of these two drugs at the behavioral level. When systemically administered within an interval of 2 h, previous administration of methylphenidate (10 mg/kg, intraperitoneal (i.p.)) did not modify locomotor activation induced by methamphetamine. On the other hand, previous administration of methamphetamine (1 mg/kg, i.p.) markedly potentiated methylphenidate-induced motor activation. With in vivo microdialysis experiments, methamphetamine and methylphenidate were found to increase DA extracellular levels in the nucleus accumbens (NAs). Methamphetamine, but not methylphenidate, significantly increased the extracellular levels of serotonin (5-HT) in the NAs. Methamphetamine-induced 5-HT release remained significantly elevated for more than 2 h after its administration, suggesting that the increased 5-HT could be responsible for the potentiation of methylphenidate-induced locomotor activation. In fact, previous administration of the 5-HT uptake blocker fluoxetine (10 mg/kg, i.p.) also potentiated the motor activation induced by methylphenidate. A selective 5-HT 1B receptor antagonist (GR 55562; 1 mg/kg), but not a 5-HT2 receptor antagonist (ritanserin; 2 mg/kg, i.p.), counteracted the effects of methamphetamine and fluoxetine on the motor activation induced by methylphenidate. Furthermore, a 5-HT 1B receptor agonist (CP 94253; 1-10 mg/kg, i.p.) strongly and dose-dependently potentiated methylphenidate-induced locomotor activation. The 5-HT 1B receptor-mediated modulation of methylphenidate-induced locomotor activation in rat could have implications for the treatment of ADHD. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Borycz, Janusz AU - Zapata, Agustin AU - Quiroz, César AU - Volkow, Nora D AU - Ferré, Sergi AD - Department of Health and Human Services, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 619 EP - 626 VL - 33 IS - 3 SN - 0893-133X, 0893-133X KW - CP 94253 KW - 0 KW - Central Nervous System Stimulants KW - Pyridines KW - Receptor, Serotonin, 5-HT1B KW - Serotonin Receptor Agonists KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Methylphenidate KW - 207ZZ9QZ49 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Animals KW - Fluoxetine -- pharmacology KW - Dose-Response Relationship, Drug KW - Nucleus Accumbens -- drug effects KW - Dopamine -- metabolism KW - Rats KW - Microdialysis KW - Rats, Sprague-Dawley KW - Extracellular Space -- metabolism KW - Methamphetamine -- pharmacology KW - Nucleus Accumbens -- metabolism KW - Serotonin Uptake Inhibitors -- pharmacology KW - Extracellular Space -- drug effects KW - Pyridines -- pharmacology KW - Male KW - Central Nervous System Stimulants -- pharmacology KW - Serotonin -- physiology KW - Methylphenidate -- pharmacology KW - Receptor, Serotonin, 5-HT1B -- physiology KW - Motor Activity -- drug effects KW - Serotonin -- metabolism KW - Receptor, Serotonin, 5-HT1B -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70202533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=5-HT+1B+receptor-mediated+serotoninergic+modulation+of+methylphenidate-induced+locomotor+activation+in+rats.&rft.au=Borycz%2C+Janusz%3BZapata%2C+Agustin%3BQuiroz%2C+C%C3%A9sar%3BVolkow%2C+Nora+D%3BFerr%C3%A9%2C+Sergi&rft.aulast=Borycz&rft.aufirst=Janusz&rft.date=2008-02-01&rft.volume=33&rft.issue=3&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-23 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dose-related enhancement of mood and cognition in smokers administered nicotine nasal spray. AN - 70202228; 17443125 AB - The discovery of the role of nicotinic receptors in attention and memory has led to the testing of nicotinic analogs as cognitive enhancing agents in patient populations. Empirical information about nicotine's ability to enhance elements of attention and memory in normal individuals might guide development of therapeutic uses of nicotine in cognitively impaired populations. The purpose of this study was to determine the effect of nicotine on continuous attention, working memory, and computational processing in tobacco-deprived and nondeprived smokers. A total of 28 smokers (14 men, 14 women) participated in a double-blind, placebo-controlled, within-subject study, in which they were overnight (12 h) tobacco deprived at one session and smoked ad libitum before the other session. At each session, participants received 0, 1, and 2 mg nicotine via nasal spray in random order at 90 min intervals. Before and after each dose, a battery of cognitive, subjective, and physiological measures was administered, and blood samples were taken for plasma nicotine concentration. Overnight tobacco deprivation resulted in impaired functioning on all cognitive tests and increased self-reports of tobacco craving and negative mood; nicotine normalized these deficits. In the nondeprived condition, nicotine enhanced performance on the continuous performance test (CPT) and an arithmetic test in a dose-related manner, but had no effect on working memory. In general, women were more sensitive than men to the subjective effects of nicotine. These results provide an unequivocal determination that nicotine enhanced attentional and computational abilities in nondeprived smokers and suggest these cognitive domains as substrates for novel therapeutic indications. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Myers, Carol S AU - Taylor, Richard C AU - Moolchan, Eric T AU - Heishman, Stephen J AD - Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, NIH Intramural Research Program, Baltimore, MD 21224, USA. cmyers@intra.nida.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 588 EP - 598 VL - 33 IS - 3 SN - 0893-133X, 0893-133X KW - Aerosols KW - 0 KW - Nicotinic Agonists KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Double-Blind Method KW - Substance Withdrawal Syndrome -- prevention & control KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Humans KW - Memory, Short-Term -- drug effects KW - Smoking Cessation -- psychology KW - Heart Rate -- drug effects KW - Psychomotor Performance -- drug effects KW - Adult KW - Substance Withdrawal Syndrome -- psychology KW - Blood Pressure -- drug effects KW - Administration, Inhalation KW - Female KW - Male KW - Affect -- drug effects KW - Cognition -- drug effects KW - Nicotinic Agonists -- blood KW - Nicotine -- pharmacology KW - Nicotine -- administration & dosage KW - Nicotine -- blood KW - Smoking -- psychology KW - Nicotinic Agonists -- pharmacology KW - Nicotinic Agonists -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70202228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Dose-related+enhancement+of+mood+and+cognition+in+smokers+administered+nicotine+nasal+spray.&rft.au=Myers%2C+Carol+S%3BTaylor%2C+Richard+C%3BMoolchan%2C+Eric+T%3BHeishman%2C+Stephen+J&rft.aulast=Myers&rft.aufirst=Carol&rft.date=2008-02-01&rft.volume=33&rft.issue=3&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-23 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2. AN - 70164600; 17999635 AB - Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder in which excessive deposition of extracellular matrix leads to irreversible scarring of interstitial lung tissue. The etiology of IPF remains unknown, but growing evidence suggests that disequilibrium in oxidant/antioxidant balance contributes significantly. IPF is currently regarded as a fibroproliferative disorder triggered by repeated alveolar epithelial cell injury. Oxidative stress plays a role in many processes involved in alveolar epithelial cell injury and fibrogenesis. Here we review the role of oxidative stress in IPF, and other forms of pulmonary fibrosis, with particular attention to antioxidant defenses regulated by the redox-sensitive transcription factor nuclear factor, erythroid derived 2, like (Nrf2). Nrf2 binds specific antioxidant response elements (AREs) in the promoter of antioxidant enzyme and defense protein genes and regulates their expression in many tissue types. Nrf2 protects from several phenotypes in which enhanced oxidative burden contributes to disease pathogenesis, including cancer, acute lung injury, and pulmonary fibrosis. We suggest that promoter polymorphisms in human NRF2 may contribute to IPF susceptibility, although this hypothesis has not been tested. Pulmonary fibrosis is a highly complex disease and involves multiple genes and processes, and new therapies for cellular and molecular targets involved in pathogenic mechanisms are needed. JF - Antioxidants & redox signaling AU - Walters, Dianne M AU - Cho, Hye-Youn AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 321 EP - 332 VL - 10 IS - 2 SN - 1523-0864, 1523-0864 KW - Antioxidants KW - 0 KW - NF-E2-Related Factor 2 KW - NFE2L2 protein, human KW - Oxidants KW - Reactive Oxygen Species KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Humans KW - Oxidants -- toxicity KW - Lung -- pathology KW - Lung -- physiopathology KW - Models, Biological KW - Antioxidants -- pharmacology KW - Pulmonary Fibrosis -- chemically induced KW - Pulmonary Fibrosis -- prevention & control KW - Pulmonary Fibrosis -- physiopathology KW - Oxidative Stress KW - NF-E2-Related Factor 2 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70164600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Oxidative+stress+and+antioxidants+in+the+pathogenesis+of+pulmonary+fibrosis%3A+a+potential+role+for+Nrf2.&rft.au=Walters%2C+Dianne+M%3BCho%2C+Hye-Youn%3BKleeberger%2C+Steven+R&rft.aulast=Walters&rft.aufirst=Dianne&rft.date=2008-02-01&rft.volume=10&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=15230864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-21 N1 - Date created - 2007-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - EEG of chronic marijuana users during abstinence: relationship to years of marijuana use, cerebral blood flow and thyroid function. AN - 70155236; 18065267 AB - Marijuana abuse is associated with neurological changes including increases in frontal EEG alpha during abstinence. Research is needed to assess to what extent these EEG patterns are indicative of cerebral perfusion deficits. We recorded the resting eyes closed EEG of 75 abstinent marijuana users and 33 control subjects. Fifty-six marijuana users used marijuana for less than eight years and 19 used for eight years or more. The EEG evaluation occurred within 72h of admission to an inpatient unit. Fifty-nine marijuana users remained abstinent for a month and were tested twice. Supplemental psychological and physiological data were also collected. Log alpha2 and beta2 power at posterior sites were significantly lower for the marijuana abusers that used eight years or more than the other marijuana abusers and the control subjects. These EEG changes continued for the month of abstinence. The marijuana users who used marijuana for more than eight years, also, had lower heart rates and thyroid function (T4) compared to the other marijuana users and the control subjects. Chronic marijuana use was also associated with reduced EEG power in alpha and beta bands at posterior sites. These reductions in EEG power appear to be related to cerebral perfusion deficits and/or thyroid function in marijuana abusers. Our results suggest EEG, cerebral blood flow velocity, cardiovascular and thyroid function alterations in marijuana abuser with an extended period of use. These alterations reflect under arousal in these systems. JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology AU - Herning, Ronald I AU - Better, Warren AU - Cadet, Jean L AD - Molecular Neuropsychiatry Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. rherning@intra.nida.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 321 EP - 331 VL - 119 IS - 2 SN - 1388-2457, 1388-2457 KW - Index Medicus KW - Heart Rate -- drug effects KW - Ultrasonography, Doppler, Duplex KW - Spectrum Analysis KW - Humans KW - Blood Flow Velocity -- drug effects KW - Adult KW - Heart Rate -- physiology KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Brain Mapping KW - Substance Withdrawal Syndrome -- physiopathology KW - Thyroid Gland -- drug effects KW - Cerebrovascular Circulation -- physiology KW - Cerebrovascular Circulation -- drug effects KW - Marijuana Smoking -- physiopathology KW - Thyroid Gland -- physiopathology KW - Alpha Rhythm UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70155236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+neurophysiology+%3A+official+journal+of+the+International+Federation+of+Clinical+Neurophysiology&rft.atitle=EEG+of+chronic+marijuana+users+during+abstinence%3A+relationship+to+years+of+marijuana+use%2C+cerebral+blood+flow+and+thyroid+function.&rft.au=Herning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean+L&rft.aulast=Herning&rft.aufirst=Ronald&rft.date=2008-02-01&rft.volume=119&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Clinical+neurophysiology+%3A+official+journal+of+the+International+Federation+of+Clinical+Neurophysiology&rft.issn=13882457&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2007-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pediatr Neurosurg. 2000 Feb;32(2):92-4 [10838508] Cerebrovasc Dis. 2001;11(3):284-5 [11306781] Arch Gen Psychiatry. 2001 Oct;58(10):917-24 [11576029] Clin Neurophysiol. 2001 Oct;112(10):1901-11 [11595150] Neuropsychopharmacology. 2001 Nov;25(5 Suppl):S57-62 [11682275] Neurotoxicol Teratol. 2001 Sep-Oct;23(5):437-43 [11711246] South Med J. 2001 Dec;94(12):1217-8 [11811864] JAMA. 2002 Mar 6;287(9):1123-31 [11879109] Pharmacol Biochem Behav. 2002 May;72(1-2):237-50 [11900794] Headache. 2002 Mar;42(3):224-6 [11903547] Pediatr Clin North Am. 2002 Apr;49(2):389-413 [11993290] J Clin Pharmacol. 2002 Nov;42(11 Suppl):48S-57S [12412836] Neurology. 2002 Nov 12;59(9):1337-43 [12427880] Drug Alcohol Depend. 2003 Apr 1;69(3):303-10 [12633916] Alcohol Clin Exp Res. 2003 May;27(5):765-72 [12766620] J Am Acad Child Adolesc Psychiatry. 2004 Feb;43(2):154-62 [14726721] Int J Psychophysiol. 2004 Feb;51(3):239-51 [14962576] J Clin Psychol. 1996 Nov;52(6):639-50 [8912107] Postgrad Med J. 1996 Nov;72(853):692-3 [8944217] Postgrad Med J. 1997 Jul;73(861):448 [9338042] Acta Neurol Scand. 1997 Dec;96(6):397-400 [9449479] J Psychoactive Drugs. 1998 Apr-Jun;30(2):209-14 [9692384] AJR Am J Roentgenol. 1999 Jan;172(1):213-8 [9888770] Psychopharmacology (Berl). 1999 Feb;141(4):395-404 [10090647] Psychopharmacology (Berl). 1999 Mar;142(3):295-301 [10208322] Alcohol Clin Exp Res. 1999 Aug;23(8):1312-9 [10470973] Drug Alcohol Depend. 1999 Oct 1;56(3):167-79 [10529019] J Consult Psychol. 1957 Aug;21(4):343-9 [13463189] J Clin Neurophysiol. 2004 Sep-Oct;21(5):341-52 [15592008] Neurology. 2005 Feb 8;64(3):488-93 [15699380] Psychiatry Res. 2005 Jul 15;136(1):7-15 [16026854] Curr Psychiatry Rep. 2005 Oct;7(5):360-6 [16216154] BMJ. 2006 Jan 21;332(7534):172-5 [16424500] Methods Mol Med. 2006;123:255-68 [16506413] Neurology. 2006 Mar 14;66(5):737-9 [16534113] Can J Psychiatry. 2006 Aug;51(9):566-74 [17007223] Exp Clin Psychopharmacol. 2006 Nov;14(4):422-8 [17115869] Alcohol Alcohol. 2004 May-Jun;39(3):233-40 [15082461] JAMA. 2004 May 5;291(17):2114-21 [15126440] J Consult Clin Psychol. 1974 Dec;42(6):861-5 [4436473] Clin Pharmacol Ther. 1976 Jun;19(6):782-94 [178475] J Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):143S-152S [6271820] Electroencephalogr Clin Neurophysiol. 1982 Jan;53(1):119-24 [6173196] Drug Alcohol Depend. 1982 Dec;10(4):345-53 [6299682] Psychophysiology. 1984 Jan;21(1):72-8 [6701247] Psychiatry Res. 1986 Jan;17(1):15-21 [3484830] Science. 1988 Jan 8;239(4836):162-9 [3336779] Postgrad Med J. 1987 Jun;63(740):511 [3501584] Clin Electroencephalogr. 1989 Jan;20(1):6-23 [2784363] Biol Psychiatry. 1989 Oct;26(6):595-611 [2790098] Stroke. 1991 Mar;22(3):406-9 [2003312] J Health Soc Behav. 1991 Mar;32(1):80-99 [2007763] Stroke. 1992 Sep;23(9):1381 [1519298] J Neurol Sci. 1993 Oct;119(1):8-17 [8246015] Clin Electroencephalogr. 1994 Apr;25(2):63-75 [8194190] JAMA. 1996 Feb 21;275(7):521-7 [8606472] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. AN - 69163815; 18166498 AB - The PI3K/Akt/mTOR pathway is a prototypic survival pathway that is constitutively activated in many types of cancer. Mechanisms for pathway activation include loss of tumor suppressor PTEN function, amplification or mutation of PI3K, amplification or mutation of Akt, activation of growth factor receptors, and exposure to carcinogens. Once activated, signaling through Akt can be propagated to a diverse array of substrates, including mTOR, a key regulator of protein translation. This pathway is an attractive therapeutic target in cancer because it serves as a convergence point for many growth stimuli, and through its downstream substrates, controls cellular processes that contribute to the initiation and maintenance of cancer. Moreover, activation of the Akt/mTOR pathway confers resistance to many types of cancer therapy, and is a poor prognostic factor for many types of cancers. This review will provide an update on the clinical progress of various agents that target the pathway, such as the Akt inhibitors perifosine and PX-866 and mTOR inhibitors (rapamycin, CCI-779, RAD-001) and discuss strategies to combine these pathway inhibitors with conventional chemotherapy, radiotherapy, as well as newer targeted agents. We will also discuss how the complex regulation of the PI3K/Akt/mTOR pathway poses practical issues concerning the design of clinical trials, potential toxicities and criteria for patient selection. JF - Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy AU - LoPiccolo, Jaclyn AU - Blumenthal, Gideon M AU - Bernstein, Wendy B AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889, United States. PY - 2008 SP - 32 EP - 50 VL - 11 IS - 1-2 KW - Protein Kinases KW - EC 2.7.- KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Animals KW - Combined Modality Therapy KW - Humans KW - Signal Transduction -- drug effects KW - Treatment Outcome KW - Clinical Trials as Topic KW - Substrate Specificity KW - Protein Kinases -- metabolism KW - Neoplasms -- drug therapy KW - Neoplasms -- enzymology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Phosphatidylinositol 3-Kinases -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69163815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+resistance+updates+%3A+reviews+and+commentaries+in+antimicrobial+and+anticancer+chemotherapy&rft.atitle=Targeting+the+PI3K%2FAkt%2FmTOR+pathway%3A+effective+combinations+and+clinical+considerations.&rft.au=LoPiccolo%2C+Jaclyn%3BBlumenthal%2C+Gideon+M%3BBernstein%2C+Wendy+B%3BDennis%2C+Phillip+A&rft.aulast=LoPiccolo&rft.aufirst=Jaclyn&rft.date=2008-02-01&rft.volume=11&rft.issue=1-2&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Drug+resistance+updates+%3A+reviews+and+commentaries+in+antimicrobial+and+anticancer+chemotherapy&rft.issn=1532-2084&rft_id=info:doi/10.1016%2Fj.drup.2007.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-21 N1 - Date created - 2008-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 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[17452630] Science. 2007 May 18;316(5827):1039-43 [17463250] N Engl J Med. 2007 May 31;356(22):2271-81 [17538086] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.drup.2007.11.003 ER - TY - JOUR T1 - Activity-dependent neuron-glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell development. AN - 66699406; 19267953 AB - Activity-dependent signaling between neurons and astrocytes contributes to experience-dependent plasticity and development of the nervous system. However, mechanisms responsible for neuron-glial interactions and the releasable factors that underlie these processes are not well understood. The pro-inflammatory cytokine, leukemia-inhibitory factor (LIF), is transiently expressed postnatally by glial cells in the hippocampus and rapidly up-regulated by enhanced neural activity following seizures. To test the hypothesis that spontaneous neural activity regulates glial development in hippocampus via LIF signaling, we blocked spontaneous activity with the sodium channel blocker tetrodotoxin (TTX) in mixed hippocampal cell cultures in combination with blockers of LIF and purinergic signaling. TTX decreased the number of GFAP-expressing astrocytes in hippocampal cell culture. Furthermore, blocking purinergic signaling by P2Y receptors contributed to reduced numbers of astrocytes. Blocking activity or purinergic signaling in the presence of function-blocking antibodies to LIF did not further decrease the number of astrocytes. Moreover, hippocampal cell cultures prepared from LIF -/- mice had reduced numbers of astrocytes and activity-dependent neuron-glial signaling promoting differentiation of astrocytes was absent. The results show that endogenous LIF is required for normal development of hippocampal astrocytes, and this process is regulated by spontaneous neural impulse activity through the release of ATP. JF - Neuron glia biology AU - Cohen, Jonathan E AU - Fields, R Douglas AD - Nervous System Development and Plasticity Section, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 43 EP - 55 VL - 4 IS - 1 KW - Leukemia Inhibitory Factor KW - 0 KW - Lif protein, mouse KW - P2ry1 protein, mouse KW - Purinergic P2 Receptor Antagonists KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2Y1 KW - Sodium Channel Blockers KW - Tetrodotoxin KW - 4368-28-9 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Animals KW - Neurons -- metabolism KW - Synaptic Transmission -- drug effects KW - Cell Differentiation -- genetics KW - Neuronal Plasticity -- physiology KW - Mice KW - Synaptic Transmission -- physiology KW - Mice, Knockout KW - Up-Regulation -- physiology KW - Rats KW - Signal Transduction -- physiology KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Receptors, Purinergic P2 -- metabolism KW - Sodium Channel Blockers -- pharmacology KW - Cell Communication -- physiology KW - Neuronal Plasticity -- drug effects KW - Tetrodotoxin -- pharmacology KW - Female KW - Male KW - Astrocytes -- cytology KW - Hippocampus -- growth & development KW - Leukemia Inhibitory Factor -- genetics KW - Hippocampus -- metabolism KW - Hippocampus -- cytology KW - Adenosine Triphosphate -- metabolism KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66699406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron+glia+biology&rft.atitle=Activity-dependent+neuron-glial+signaling+by+ATP+and+leukemia-inhibitory+factor+promotes+hippocampal+glial+cell+development.&rft.au=Cohen%2C+Jonathan+E%3BFields%2C+R+Douglas&rft.aulast=Cohen&rft.aufirst=Jonathan&rft.date=2008-02-01&rft.volume=4&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Neuron+glia+biology&rft.issn=1741-0533&rft_id=info:doi/10.1017%2FS1740925X09000076 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-17 N1 - Date created - 2009-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2005 Oct 20;48(2):253-65 [16242406] Science. 2005 Oct 7;310(5745):113-6 [16210541] Brain Res. 2006 Feb 23;1075(1):26-35 [16458863] Neuron. 2006 Mar 16;49(6):823-32 [16543131] J Neurosci. 2006 May 17;26(20):5438-47 [16707796] Cell. 2006 May 19;125(4):775-84 [16713567] Nat Rev Neurosci. 2006 Jun;7(6):423-36 [16715052] Nature. 2006 Dec 7;444(7120):707-12 [17151658] Pflugers Arch. 2006 Aug;452(5):479-85 [16688467] Physiol Rev. 2006 Jul;86(3):1009-31 [16816144] Dev Biol. 2007 Feb 1;302(1):356-66 [17188262] Nat Rev Neurosci. 2007 Mar;8(3):221-32 [17311007] J Neurophysiol. 2007 Mar;97(3):2564-9 [17035364] Brain Struct Funct. 2007 Jul;212(1):19-35 [17717696] J Neurosci. 2007 Oct 17;27(42):11354-65 [17942730] Stem Cells. 2009 Feb;27(2):431-41 [19023034] Glia. 2007 Jan 15;55(2):165-77 [17078026] Trends Neurosci. 2000 Dec;23(12):625-33 [11137153] Science. 2001 Jan 26;291(5504):657-61 [11158678] Mech Ageing Dev. 2002 Mar 15;123(5):481-90 [11796133] J Neuroimmunol. 2002 Aug;129(1-2):43-50 [12161019] J Neurochem. 2002 Oct;83(1):100-9 [12358733] Brain Res Dev Brain Res. 2002 Nov 15;139(1):9-17 [12414089] Brain Res Mol Brain Res. 2002 Oct 30;107(1):39-46 [12414122] Trends Neurosci. 2003 Nov;26(11):590-6 [14585598] Neuroscience. 2003;122(2):329-48 [14614900] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15194-9 [14638938] Brain Res Dev Brain Res. 2004 Jan 31;148(1):77-87 [14757521] Neuropsychopharmacology. 2004 Apr;29(4):770-6 [14970834] Neurosci Res. 2004 Mar;48(3):345-53 [15154680] Neuron. 2004 Sep 2;43(5):647-61 [15339647] Science. 1989 Dec 15;246(4936):1412-6 [2512641] Glia. 1990;3(6):487-94 [2148551] Brain Res. 1991 Feb 1;540(1-2):273-8 [2054618] Nature. 1992 Sep 3;359(6390):76-9 [1522892] Nature. 1993 Jan 21;361(6409):258-60 [8093806] Acta Neuropathol. 1994;87(1):8-13 [8140897] Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):7839-43 [7914698] J Neurosci. 1994 Nov;14(11 Pt 1):6402-11 [7965045] Brain Res. 1995 Jun 19;683(2):187-99 [7552354] Psychoneuroendocrinology. 1996 Feb;21(2):189-201 [8774062] Int J Dev Neurosci. 1995 Nov;13(7):685-93 [8787859] J Neuroimmunol. 1996 Oct;70(1):45-53 [8862134] Neurosci Lett. 1996 Sep 13;215(3):205-8 [8899749] Br J Pharmacol. 1997 Aug;121(8):1692-9 [9283705] Science. 1997 Sep 12;277(5332):1684-7 [9287225] Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3178-81 [9501236] J Neurobiol. 1998 Sep 15;36(4):509-24 [9740023] Brain Res Dev Brain Res. 1998 Oct 1;110(2):177-84 [9748562] Exp Neurol. 1999 Oct;159(2):333-46 [10506506] Development. 2005 Dec;132(24):5503-14 [16314487] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1017/S1740925X09000076 ER - TY - JOUR T1 - Social impact of preventive HIV vaccine clinical trial participation: A model of prevention, assessment and intervention AN - 61672724; 200817039 AB - Preventive HIV vaccine trial participants may experience problems related to trial participation, including difficulties with personal relationships, employment, education, health care, housing, health insurance, disability insurance, life insurance, travel or immigration. During the 19 years that the U.S.-based National Institute of Allergy and Infectious Diseases (NIAID) has conducted preventive HIV vaccine trials, we have developed a model to prevent and resolve social impact related to study participation and assist study participants who report such events. Key elements of the model include: informing potential volunteers of risks prior to enrollment; standardizing data collection methods on social impact events; reviewing and following-up on reported social impact events; assisting participants, including provision of free HIV testing to differentiate HIV infection from vaccine-induced HIV antibody; implementing broad-based and targeted community education programs for achieving community support; communicating with scientific and health care communities; and working with government agencies, non-government agencies and industry on mechanisms to address SI. This approach, established in collaboration with NIAID-funded clinical trial groups, serves as a model for prevention, assessment, monitoring, and intervention for social impact related to preventive HIV vaccine clinical trial participation. Although further research is necessary, this model could be adapted for use in different clinical trials. [Copyright 2007 Elsevier Ltd.] JF - Social Science & Medicine AU - Allen, Mary AU - Lau, Chuen-Yen AD - National Institutes of Health, Bethesda, MD 20817, USA mallen@niaid.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 945 EP - 951 PB - Elsevier Science, Amsterdam The Netherlands VL - 66 IS - 4 SN - 0277-9536, 0277-9536 KW - Social impact KW - Social harm KW - HIV vaccine KW - Clinical trial KW - USA KW - NIAID KW - Health Research KW - Acquired Immune Deficiency Syndrome KW - Disability Recipients KW - United States of America KW - Patients KW - Health Care Services KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61672724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Social+impact+of+preventive+HIV+vaccine+clinical+trial+participation%3A+A+model+of+prevention%2C+assessment+and+intervention&rft.au=Allen%2C+Mary%3BLau%2C+Chuen-Yen&rft.aulast=Allen&rft.aufirst=Mary&rft.date=2008-02-01&rft.volume=66&rft.issue=4&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2007.10.019 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-06-11 N1 - Number of references - 9 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Health Care Services; United States of America; Disability Recipients; Patients; Acquired Immune Deficiency Syndrome; Health Research DO - http://dx.doi.org/10.1016/j.socscimed.2007.10.019 ER - TY - JOUR T1 - Understanding the role of cancer worry in creating a 'teachable moment' for multiple risk factor reduction AN - 61365288; 201000439 AB - The manuscript examines the influence of contextual factors on whether and for whom a colon polyp diagnosis might be a teachable moment, as indicated by engagement with a proactively delivered intervention. Baseline and 8-month follow-up data were analyzed from a two-site behavioral intervention trial with patients in Massachusetts and North Carolina, USA who had recently undergone polypectomy for pre-cancerous colon polyps and were randomized to a behavior change intervention condition (N=591). Intervention 'buy-in' was used as an indicator of response consistent with the polyp identification serving as a teachable moment. Cancer worry, personal risk, health-related self-identity and other sociodemographic factors were tested to predict intervention buy-in. As predicted, those who were most worried about colon cancer were most likely to engage in the intervention. One indicator of personal risk, number of risk behaviors, was significantly and negatively associated with buy-in. Predictors of intervention buy-in and cancer worry were not consistent. We recommend that expanded measures of affect and health-related self-identity should be considered in future research to understand the motivational potential of health events for increasing engagement in effective behavior change interventions. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - McBride, Colleen M AU - Puleo, Elaine AU - Pollak, Kathryn I AU - Clipp, Elizabeth C AU - Woolford, Sam AU - Emmons, Karen M AD - National Human Genome Research Institute, Social and Behavioral Research Branch, 2 Center Drive, Building 2, Room E408, Bethesda, MD, USA cmcbride@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 790 EP - 800 PB - Elsevier Science, Amsterdam The Netherlands VL - 66 IS - 3 SN - 0277-9536, 0277-9536 KW - Worry Teachable moment Behavior change USA Colon cancer KW - Behavior KW - Change KW - Patients KW - Health Education KW - Cancer KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61365288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Understanding+the+role+of+cancer+worry+in+creating+a+%27teachable+moment%27+for+multiple+risk+factor+reduction&rft.au=McBride%2C+Colleen+M%3BPuleo%2C+Elaine%3BPollak%2C+Kathryn+I%3BClipp%2C+Elizabeth+C%3BWoolford%2C+Sam%3BEmmons%2C+Karen+M&rft.aulast=McBride&rft.aufirst=Colleen&rft.date=2008-02-01&rft.volume=66&rft.issue=3&rft.spage=790&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2007.10.014 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-01-05 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Behavior; Change; Health Education; Cancer; Patients; Health Care Services DO - http://dx.doi.org/10.1016/j.socscimed.2007.10.014 ER - TY - JOUR T1 - BEYOND ACCOUNTABILITY FOR REASONABLENESS AN - 57288085; 200914719 AB - This paper is a critique of Norman Daniels' and James Sabin's 'Accountability for Reasonableness' framework for making priority-setting decisions in health care in the face of widespread disagreement about values. Accountability for Reasonableness has been rapidly gaining worldwide acceptance, arguably to the point of becoming the dominant paradigm in the field of health policy. The framework attempts to set ground rules for a procedure that ensures that whatever decisions result will be fair, reasonable, and legitimate to the extent that even those who would be adversely affected will have reason to abide by them. I argue that the framework's four conditions are inadequate to this task. While we certainly require a fair and legitimate procedure for making priority setting decisions in health care despite a lack of consensus on relevant ethical and political issues, we must significantly revise the four conditions, and we cannot avoid facing our substantive disagreements head on if we hope to arrive at decisions that would (and should) be acceptable to everyone. I offer two suggestions. First, there is need for greater public involvement in all stages of deliberation. Second, we should give up on the idea that we can simplify the task of democratic deliberation by disallowing particular kinds or reasons and types of reasoning. Reasons of all kinds should be on the table, but then should be judged on their merits, such as consistency, plausibility and explanatory power, without any regard for their alleged sources of authority. Adapted from the source document. JF - Bioethics AU - Friedman, Alex AD - Department of Clinical Bioethics at the National Institutes of Health friedmana@cc.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 101 EP - 112 PB - Blackwell, Oxford UK VL - 22 IS - 2 SN - 0269-9702, 0269-9702 KW - Acceptance KW - Health care KW - Authority KW - Prioritizing KW - Accountability KW - Models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57288085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioethics&rft.atitle=BEYOND+ACCOUNTABILITY+FOR+REASONABLENESS&rft.au=Friedman%2C+Alex&rft.aulast=Friedman&rft.aufirst=Alex&rft.date=2008-02-01&rft.volume=22&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Bioethics&rft.issn=02699702&rft_id=info:doi/10.1111%2Fj.1467-8519.2007.00605.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - CODEN - BIETEE N1 - SubjectsTermNotLitGenreText - Accountability; Prioritizing; Health care; Models; Acceptance; Authority DO - http://dx.doi.org/10.1111/j.1467-8519.2007.00605.x ER - TY - JOUR T1 - Weight Management Using the Internet: A Randomized Controlled Trial AN - 57237623; 200811816 AB - Background Most weight-loss research targets obese individuals who desire large weight reductions. However, evaluation of weight-gain prevention in overweight individuals is also critical as most Americans become obese as a result of a gradual gain of 1-2 pounds per year over many years. Method This study evaluated the efficacy of an Internet-based program for weight-loss and weight-gain prevention with a two-group, prospective, randomized controlled trial. A military medical research center with a population of 17,000 active-duty military personnel supplied 446 overweight individuals (222 men; 224 women) with a mean age of 34 years and a mean BMI of 29. Recruitment and study participation occurred 2003-2005 and data were analyzed in 2006. Participants were randomly assigned to receive the 6-month behavioral Internet treatment (BIT, n=227) or usual care (n=224). Change in body weight, BMI, percent body fat, and waist circumference; presented as group by time interactions, were measured. Results After 6 months, completers who received BIT lost 1.3 kg while those assigned to usual care gained 0.6 kg (F(df=366)=24.17; I<0.001). Results were similar for the intention-to-treat model. BIT participants also had significant changes in BMI (-0.5 vs +0.2 kg/m2; F(df=366)=24.58); percent body fat (-0.4 vs +0.6%; F(df=366)=10.45); and waist circumference (-2.1 vs -0.4 cm; F(df=366)=17.09); p<0.001 for all. Conclusions Internet-based weight-management interventions result in small amounts of weight loss, prevent weight gain, and have potential for widespread dissemination as a population health approach. Trial Registration NCT00417599. [Copyright 2008 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Hunter, Christine M AU - Peterson, Alan L AU - Alvarez, Lisa M AU - Poston, Walker C AU - Brundige, Antoinette R AU - Haddock, C Keith AU - Van Brunt, David L AU - Foreyt, John P AD - Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland hunterchristine@niddk.nih.gov Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 119 EP - 126 PB - Elsevier Science, New York NY VL - 34 IS - 2 SN - 0749-3797, 0749-3797 KW - Obesity KW - Computer assisted counselling KW - Behavioural health education KW - Weight loss KW - Internet KW - Preventive programmes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57237623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Weight+Management+Using+the+Internet%3A+A+Randomized+Controlled+Trial&rft.au=Hunter%2C+Christine+M%3BPeterson%2C+Alan+L%3BAlvarez%2C+Lisa+M%3BPoston%2C+Walker+C%3BBrundige%2C+Antoinette+R%3BHaddock%2C+C+Keith%3BVan+Brunt%2C+David+L%3BForeyt%2C+John+P&rft.aulast=Hunter&rft.aufirst=Christine&rft.date=2008-02-01&rft.volume=34&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.09.026 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Obesity; Weight loss; Preventive programmes; Internet; Behavioural health education; Computer assisted counselling DO - http://dx.doi.org/10.1016/j.amepre.2007.09.026 ER - TY - CPAPER T1 - Magnetic Resonance Imaging for the Diagnosis of Subcutaneous Involvement in Patients with Chronic Graft-versus-Host Disease. T2 - 66th Annual Meeting of the American Academy of Dermatology AN - 40842365; 4817926 JF - 66th Annual Meeting of the American Academy of Dermatology AU - Clark, Jason A AU - Yao, Lawrence AU - Turner, Maria L AU - Cowen, Edward W Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 KW - Graft-versus-host reaction KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40842365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=66th+Annual+Meeting+of+the+American+Academy+of+Dermatology&rft.atitle=Magnetic+Resonance+Imaging+for+the+Diagnosis+of+Subcutaneous+Involvement+in+Patients+with+Chronic+Graft-versus-Host+Disease.&rft.au=Clark%2C+Jason+A%3BYao%2C+Lawrence%3BTurner%2C+Maria+L%3BCowen%2C+Edward+W&rft.aulast=Clark&rft.aufirst=Jason&rft.date=2008-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=66th+Annual+Meeting+of+the+American+Academy+of+Dermatology&rft.issn=&rft_id=info:doi/ L2 - http://www.aad.org/meetings/previous/_doc/Posters_2008%20Annual%20Meet ing.pdf. LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Body Weight Supported Treadmill Training in Retraining Gait after Stroke: Randomized Controlled Study T2 - 2nd International Congress on Gait and Mental Function AN - 40782089; 4788269 JF - 2nd International Congress on Gait and Mental Function AU - Srivastava, A AU - Gupta, A AU - Taly, A B AU - Murali, T AU - Sendhil, K Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 KW - Training KW - Body weight KW - Stroke KW - Gait KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2nd+International+Congress+on+Gait+and+Mental+Function&rft.atitle=Role+of+Body+Weight+Supported+Treadmill+Training+in+Retraining+Gait+after+Stroke%3A+Randomized+Controlled+Study&rft.au=Srivastava%2C+A%3BGupta%2C+A%3BTaly%2C+A+B%3BMurali%2C+T%3BSendhil%2C+K&rft.aulast=Srivastava&rft.aufirst=A&rft.date=2008-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2nd+International+Congress+on+Gait+and+Mental+Function&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/gait/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between Balance Impairment, Falls and Age-Related White Matter Lesions in MRI: A Population Based Age, Gene/Environment Susceptibility-Reykjavik Study. T2 - 2nd International Congress on Gait and Mental Function AN - 40781135; 4788215 JF - 2nd International Congress on Gait and Mental Function AU - Pajala, S AU - Petersen, H AU - Siggeirsdottir, K AU - Sigurdsson, G AU - Eiriksdottir, G AU - Jonsson, P V AU - Lang, T AU - Harris, T AU - vanBuchem, M AU - Launer, L Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 KW - Lesions KW - Age KW - Magnetic resonance imaging KW - Substantia alba KW - Population genetics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2nd+International+Congress+on+Gait+and+Mental+Function&rft.atitle=Association+between+Balance+Impairment%2C+Falls+and+Age-Related+White+Matter+Lesions+in+MRI%3A+A+Population+Based+Age%2C+Gene%2FEnvironment+Susceptibility-Reykjavik+Study.&rft.au=Pajala%2C+S%3BPetersen%2C+H%3BSiggeirsdottir%2C+K%3BSigurdsson%2C+G%3BEiriksdottir%2C+G%3BJonsson%2C+P+V%3BLang%2C+T%3BHarris%2C+T%3BvanBuchem%2C+M%3BLauner%2C+L&rft.aulast=Pajala&rft.aufirst=S&rft.date=2008-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2nd+International+Congress+on+Gait+and+Mental+Function&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/gait/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Reasons and requirements AN - 36981172; 3777855 AB - In this essay I defend the claim that all reasons can ground final requirements. I begin by establishing a prima facie case for the thesis by noting that on a common-sense understanding of what finality is, it must be the case that all reasons can ground such requirements. I spend the rest of the paper defending the thesis against two recent challenges. The first challenge is found in Joshua Gert's recent book, Brute Rationality. In it he argues that reasons play two logically distinct roles - requiring action and justifying action. He argues, further, that some reasons - 'purely justificatory' reasons - play only the latter role. Jonathan Dancy offers the second challenge in his Ethics Without Principles, where he distinguishes between the 'favoring' and 'ought-making' roles of reasons. While all reasons play the former role, some do not play the latter, and are therefore irrelevant to what one ought to do. My contention is that both Gert and Dancy are going to have trouble accounting for our intuitions in a number of cases. Reprinted by permission of Springer JF - Ethical theory and moral practice AU - Sachs, B AD - National Institutes of Health Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 73 EP - 83 VL - 11 IS - 1 SN - 1386-2820, 1386-2820 KW - Sociology KW - Ethics KW - Moral philosophy KW - Rationality KW - Reason UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36981172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethical+theory+and+moral+practice&rft.atitle=Reasons+and+requirements&rft.au=Sachs%2C+B&rft.aulast=Sachs&rft.aufirst=B&rft.date=2008-02-01&rft.volume=11&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Ethical+theory+and+moral+practice&rft.issn=13862820&rft_id=info:doi/10.1007%2Fs10677-007-9086-2 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10642 2688 2449 10404; 10620; 8279 9486; 4408 8282 8281 6085 DO - http://dx.doi.org/10.1007/s10677-007-9086-2 ER - TY - JOUR T1 - Why do captive tufted capuchins (Cebus apella) urine wash? AN - 36951957; 3764789 AB - Urine washing (UW) has been observed in numerous species of prosimians and New World monkeys. The functional significance of UW in Cebidae, specifically, Cebus apella, has not been determined. The objective of our study was to test two major hypotheses related to the function of UW: (1) UW functions as a thermoregulatory mechanism, and (2) UW functions as a means of social communication related to (a) territoriality, (b) sexual encounters, or (c) intragroup aggression/agitation. We collected focal data on a captive group of 28 tufted capuchins (C. apella; July-October 2004 and February-July 2005). We found no significant correlation between UW rates and temperature, at a constant, moderate humidity level. Rates of UW were significantly greater outdoors (no conspecific neighbors) vs. indoors (conspecific neighbors). Qualitative evidence suggests a relationship between UW by the alpha male and sexual solicitations from females. UW rates associated with aggression received were significantly higher than UW rates associated with aggression given and UW rates associated with potential fear/stress. There was also a significant negative correlation between cortisol measures and UW frequencies. Our results suggest that UW does not function in thermoregulation or in territorial communication. Alternatively, our results suggest that UW may be associated with sexual encounters and receiving aggression. Additionally, further investigation is warranted to determine whether UW is used as an appeasement mechanism or as a stress reliever or as both. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Miller, Kimran E AU - Laszlo, Katalin AU - Suomi, Stephen J AD - National Institutes of Health Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 119 EP - 126 VL - 70 IS - 2 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Sexuality KW - Data collection KW - Physical anthropology KW - Primatology KW - Primate behaviour KW - Primate biology KW - Territoriality KW - Aggression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36951957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Why+do+captive+tufted+capuchins+%28Cebus+apella%29+urine+wash%3F&rft.au=Miller%2C+Kimran+E%3BLaszlo%2C+Katalin%3BSuomi%2C+Stephen+J&rft.aulast=Miller&rft.aufirst=Kimran&rft.date=2008-02-01&rft.volume=70&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20462 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 662; 12683 12684 7197 8560 9511 4309; 11579 11538; 10145 10148 10149 1615 8573 11325; 3286; 9507 1077; 10144 10148 10149 1542 11325; 10149 DO - http://dx.doi.org/10.1002/ajp.20462 ER - TY - JOUR T1 - A randomized comparison of two instruments for measuring self-reported antiretroviral adherence AN - 36816872; 3499535 AB - A randomised trial compared two instruments for assessing self-reported adherence to antiretroviral medications: (1) a day-by-day recall instrument that elicited the number of missed doses in each of the prior three days (3-day instrument; n=64) and (2) a general recall instrument that elicited an estimate of proportion of pills taken during the prior seven days (7-day instrument; n=70). Adherence was measured at study visits over 12 months among participants in a clinical trial assessing treatment strategies for individuals with virologic failure and multidrug-resistant HIV. Participants had a median (interquartile range) of 133 (41-264) CD4 cells/ml3 and a median of 10 major HIV resistance mutations at baseline. Mean adherence levels were 90-98% throughout the study. There was a greater trend in the likelihood of 100% adherence when measured by the 3-day versus the 7-day instrument (odds ratio (OR)=1.45; p=0.06). The likelihood of consistent 100% adherence measured by either instrument decreased over time (p<0.001). Participants reporting 100% adherence at more than half of study visits had better virologic and immunologic outcomes at month-12 compared to those reporting 100% adherence at half or fewer visits (HIV RNA decline of 0.96 versus 0.51 log, respectively, p=0.02; and CD4 cell increase of 51.0 versus 17.8 cells, p=0.04). This study demonstrated the utility of the general 7-day recall adherence self-report instrument as well as the 3-day day-by-day recall adherence self-report instrument for measuring antiretroviral adherence. Self-reported adherence was significantly associated with virologic and immunologic outcomes in this population with advanced drug-resistant HIV disease. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Mannheimer, S AU - Thackeray, L AU - Hullsiek, K Huppler AU - Chesney, M AU - Gardner, E M AU - Wu, A W AU - Telzak, E E AU - Lawrence, J AU - Baxter, J AU - Friedland, G AD - Columbia University ; University of Minnesota, Minneapolis ; National Institutes of Health, Bethesda MD ; University of Colorado, Denver ; Johns Hopkins University ; Yeshiva University ; University of California, San Francisco ; Division of Infectious Diseases, Cooper University Hospital ; Yale University Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 161 EP - 169 VL - 20 IS - 2 SN - 0954-0121, 0954-0121 KW - Sociology KW - Medical sociology KW - Health care KW - Statistical analysis KW - Medicine KW - Medical treatment KW - HIV KW - Sexually transmitted diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36816872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=A+randomized+comparison+of+two+instruments+for+measuring+self-reported+antiretroviral+adherence&rft.au=Mannheimer%2C+S%3BThackeray%2C+L%3BHullsiek%2C+K+Huppler%3BChesney%2C+M%3BGardner%2C+E+M%3BWu%2C+A+W%3BTelzak%2C+E+E%3BLawrence%2C+J%3BBaxter%2C+J%3BFriedland%2C+G&rft.aulast=Mannheimer&rft.aufirst=S&rft.date=2008-02-01&rft.volume=20&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120701534699 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5703 3617 6220; 7890 5792 10484; 5775 13521; 12224 971; 11581 3617 6220; 7887 12008; 7894 DO - http://dx.doi.org/10.1080/09540120701534699 ER - TY - JOUR T1 - A Phase I Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors AN - 21246955; 8036337 AB - PURPOSE: To determine the toxicity profile, dose-limiting toxicities (DLT), and maximum tolerated dose (MTD) of ABT-751 administered orally once daily for 21 days, repeated every 28 days in a pediatric population. Experimental Design: Patients who were ,18 years with relapsed or refractory solid tumors and who were able to swallow capsules were eligible. The starting dose was 75 mg/m super(2)/d (n = 3) and was escalated to 100 (n = 6), 130 (n = 5), and 165 (n = 3) mg/m super(2)/d in cohorts of three to six patients. The MTD was determined from DLTs occurring during the first treatment cycle. RESULTS: Nineteen children (median age, 13 years; range, 5-18 years) were enrolled, and 17 were evaluable for toxicity. Diagnoses included neuroblastoma (n = 9), sarcomas (n = 9), and other solid tumors (n = 1). DLTs included fatigue, sensory neuropathy, transient hypertension, neutropenia, thrombocytopenia, nausea, vomiting, dehydration, abdominal pain, and constipation. The MTD of ABT-751 administered daily for 21 days every 28 days was 100 mg/m super(2)/d. Non-DLT at the MTD included bone marrow suppression, gastrointestinal toxicities (anorexia, abdominal pain, nausea, vomiting, and constipation), and sensory and motor neuropathies. The median number of cycles administered was one (range, one to five). Tolerance of repeated treatment cycles was poor. CONCLUSION: Fatigue, hematologic, and gastrointestinal toxicities limited the tolerability of ABT-751 administered to children on the once daily for 21 days every 28 days schedule. The MTD in children with solid tumors (100 mg/m super(2)/d daily for 21 days) was similar to the recommended dose in adults with solid tumors (200 mg fixed dose) receiving the same dosing schedule. JF - Clinical Cancer Research AU - Fox, Elizabeth AU - Maris, John M AU - Widemann, Brigitte C AU - Goodspeed, Wendy AU - Goodwin, Anne AU - Kromplewski, Marie AU - Fouts, Molly E AU - Medina, Diane AU - Cohn, Susan L AU - Krivoshik, Andrew AU - Hagey, Anne E AU - Adamson, Peter C AU - Balis, Frank M AD - Authors' Affiliations: Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, Children's Memorial Medical Center, Chicago, Illinois, and Abbott Laboratories, Abbott Park, Illinois Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 1111 EP - 1115 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 14 IS - 4 SN - 1078-0432, 1078-0432 KW - Toxicology Abstracts KW - Age KW - Fatigue KW - Vomiting KW - Pediatrics KW - Solid tumors KW - Bone marrow KW - Pain KW - Toxicity KW - Children KW - Neuroblastoma KW - Neutropenia KW - Thrombocytopenia KW - anorexia KW - Sarcoma KW - Constipation KW - Nausea KW - Tubulin KW - Neuropathy KW - Hypertension KW - Dehydration KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21246955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=A+Phase+I+Study+of+ABT-751%2C+an+Orally+Bioavailable+Tubulin+Inhibitor%2C+Administered+Daily+for+21+Days+Every+28+Days+in+Pediatric+Patients+with+Solid+Tumors&rft.au=Fox%2C+Elizabeth%3BMaris%2C+John+M%3BWidemann%2C+Brigitte+C%3BGoodspeed%2C+Wendy%3BGoodwin%2C+Anne%3BKromplewski%2C+Marie%3BFouts%2C+Molly+E%3BMedina%2C+Diane%3BCohn%2C+Susan+L%3BKrivoshik%2C+Andrew%3BHagey%2C+Anne+E%3BAdamson%2C+Peter+C%3BBalis%2C+Frank+M&rft.aulast=Fox&rft.aufirst=Elizabeth&rft.date=2008-02-01&rft.volume=14&rft.issue=4&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; Vomiting; Fatigue; Solid tumors; Pediatrics; Bone marrow; Pain; Toxicity; Children; Neuroblastoma; Neutropenia; Thrombocytopenia; anorexia; Constipation; Sarcoma; Nausea; Tubulin; Dehydration; Hypertension; Neuropathy ER - TY - JOUR T1 - Quantitative High-Throughput Screening Using a Live-Cell cAMP Assay Identifies Small-Molecule Agonists of the TSH Receptor AN - 21208034; 11621728 AB - The thyroid-stimulating hormone (TSH; thyrotropin) receptor belongs to the glycoprotein hormone receptor subfamily of 7-transmembrane spanning receptors. TSH receptor (TSHR) is expressed mainly in thyroid follicular cells and is activated by TSH, which regulates the growth and function of thyroid follicular cells. Recombinant TSH is used in diagnostic screens for thyroid cancer, especially in patients after thyroid cancer surgery. Currently, no selective small-molecule agonists of the TSHR are available. To screen for novel TSHR agonists, the authors miniaturized a commercially available cell-based cyclic adenosine 3',5' monophosphate (cAMP) assay into a 1536-well plate format. This assay uses an HEK293 cell line stably transfected with the TSHR coupled to a cyclic nucleotide gated ion channel as a biosensor. From a quantitative high-throughput screen of 73,180 compounds in parallel with a parental cell line (without the TSHR), 276 primary active compounds were identified. The activities of the selected active compounds were further confirmed in an orthogonal homogeneous time-resolved fluorescence cAMP-based assay. Forty-nine compounds in several structural classes have been confirmed as the small-molecule TSHR agonists that will serve as a starting point for chemical optimization and studies of thyroid physiology in health and disease. (Journal of Biomolecular Screening 2008:120-127) JF - Journal of Biomolecular Screening AU - Titus, Steve AU - Neumann, Susanne AU - Southall, Noel AU - Michael, Sam AU - Klumpp, Carleen AU - Yasgar, Adam AU - Shinn, Paul AU - Thomas, Craig J AU - Inglese, James AU - Gershengorn, Marvin C AU - Austin, Christopher P AD - National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, Bethesda, Maryland Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 120 EP - 127 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 13 IS - 2 SN - 1087-0571, 1087-0571 KW - Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - Receptor mechanisms KW - Cyclic AMP KW - thyroid-stimulating hormone receptors KW - Cyclic nucleotides KW - AMP KW - Hormones KW - Biosensors KW - thyrotropin receptors KW - Surgery KW - thyroid cancer KW - ion channels (cyclic nucleotide-gated) KW - high-throughput screening KW - Thyroid-stimulating hormone KW - Glycoproteins KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21208034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Quantitative+High-Throughput+Screening+Using+a+Live-Cell+cAMP+Assay+Identifies+Small-Molecule+Agonists+of+the+TSH+Receptor&rft.au=Titus%2C+Steve%3BNeumann%2C+Susanne%3BSouthall%2C+Noel%3BMichael%2C+Sam%3BKlumpp%2C+Carleen%3BYasgar%2C+Adam%3BShinn%2C+Paul%3BThomas%2C+Craig+J%3BInglese%2C+James%3BGershengorn%2C+Marvin+C%3BAustin%2C+Christopher+P&rft.aulast=Titus&rft.aufirst=Steve&rft.date=2008-02-01&rft.volume=13&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057107313786 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Fluorescence; Receptor mechanisms; thyroid-stimulating hormone receptors; Cyclic AMP; Cyclic nucleotides; AMP; Hormones; Biosensors; thyrotropin receptors; Surgery; thyroid cancer; ion channels (cyclic nucleotide-gated); high-throughput screening; Glycoproteins; Thyroid-stimulating hormone DO - http://dx.doi.org/10.1177/1087057107313786 ER - TY - JOUR T1 - Standardized views of the fetal heart using four-dimensional sonographic and tomographic imaging AN - 21064684; 8635546 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Espinoza, J AU - Romero, R AU - Kusanovic, J P AU - Gotsch, F AU - Lee, W AU - Goncalves, L F AU - Hassan, S S AD - Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD and Detroit, MI, USA, prbchiefstaff@med.wayne.edu Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 233 EP - 242 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 31 IS - 2 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Gynecology KW - Ultrasound KW - imaging KW - Obstetrics KW - Fetuses KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21064684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Standardized+views+of+the+fetal+heart+using+four-dimensional+sonographic+and+tomographic+imaging&rft.au=Espinoza%2C+J%3BRomero%2C+R%3BKusanovic%2C+J+P%3BGotsch%2C+F%3BLee%2C+W%3BGoncalves%2C+L+F%3BHassan%2C+S+S&rft.aulast=Espinoza&rft.aufirst=J&rft.date=2008-02-01&rft.volume=31&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.5250 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; imaging; Fetuses; Gynecology; Heart; Ultrasound DO - http://dx.doi.org/10.1002/uog.5250 ER - TY - JOUR T1 - Ex Vivo Cytokine and Memory T Cell Responses to the 42-kDa Fragment of Plasmodium falciparum Merozoite Surface Protein-1 in Vaccinated Volunteers AN - 21053470; 8039530 AB - A number of blood-stage malaria Ags are under development as vaccine candidates, but knowledge of the cellular responses to these vaccines in humans is limited. We evaluated the nature and specificity of cellular responses in healthy American volunteers vaccinated with a portion of the major merozoite surface protein-1 (MSP1) of Plasmodium falciparum, MSP1 sub(42), formulated on Alhydrogel. Volunteers were vaccinated three times with 80 mu g of either MSP1 sub(42)-FVO/Alhydrogel or MSP1 sub(42)-3D7/Alhydrogel. Cells collected 2 wk after the third vaccination produced Th1 cytokines, including IFN- gamma and IL-2 following Ag stimulation, and greater levels of the Th2 cytokines IL-5 and IL-13; the anti-inflammatory cytokine IL-10 and the molecule CD25 (IL-2R alpha ) were also detected. The volunteers were evaluated for the MSP1 sub(42)-FVO or MSP1 sub(42)-3D7 specificity of their T cell responses. Comparison of their responses to homologous and heterologous Ags showed ex vivo IFN- gamma and IL-5 levels that were significantly higher to homologous rather than to heterologous Ags. The epitopes involved in this stimulation were shown to be present in the dimorphic MSP1 sub(33) portion of the larger MSP1 sub(42)-3D7 polypeptide, and indirect experiment suggests the same for the MSP1 sub(42)-FVO polypeptide. This contrasts with B cell responses, which were primarily directed to the conserved MSP1 sub(19) portion. Furthermore, we explored the maturation of memory T cells and found that 46% of vaccinees showed specific memory T cells defined as CD4 super(+)CD45RO super(+)CD40L super(+) after long-term in vitro culture. The identification of human-specific CD4 super(+) memory T cells provides the foundation for future studies of these cells both after vaccination and in field studies. JF - Journal of Immunology AU - Huaman, Maria Cecilia AU - Martin, Laura B AU - Malkin, Elissa AU - Narum, David L AU - Miller, Louis H AU - Mahanty, Siddhartha AU - Long, Carole A AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852. Laboratory of Malaria and Vector Research, and Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 1451 EP - 1461 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 3 SN - 0022-1767, 0022-1767 KW - Aqualine Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - gamma -Interferon KW - Interleukin 5 KW - Interleukin 2 KW - Lymphocytes B KW - Helper cells KW - Immunological memory KW - Memory cells KW - Cell culture KW - Malaria KW - Plasmodium falciparum KW - CD25 antigen KW - Interleukin 2 receptors KW - Interleukin 10 KW - CD4 antigen KW - Interleukin 13 KW - Cultures KW - Lymphocytes T KW - Cytokines KW - Merozoites KW - Vaccines KW - Epitopes KW - AQ 00001:Water Resources and Supplies KW - K 03350:Immunology KW - F 06905:Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21053470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Ex+Vivo+Cytokine+and+Memory+T+Cell+Responses+to+the+42-kDa+Fragment+of+Plasmodium+falciparum+Merozoite+Surface+Protein-1+in+Vaccinated+Volunteers&rft.au=Huaman%2C+Maria+Cecilia%3BMartin%2C+Laura+B%3BMalkin%2C+Elissa%3BNarum%2C+David+L%3BMiller%2C+Louis+H%3BMahanty%2C+Siddhartha%3BLong%2C+Carole+A&rft.aulast=Huaman&rft.aufirst=Maria&rft.date=2008-02-01&rft.volume=180&rft.issue=3&rft.spage=1451&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Interleukin 5; Interleukin 2; Lymphocytes B; Helper cells; Memory cells; Immunological memory; Malaria; Cell culture; CD25 antigen; Interleukin 10; Interleukin 2 receptors; Interleukin 13; CD4 antigen; Lymphocytes T; Cytokines; Merozoites; Vaccines; Epitopes; Cultures; Plasmodium falciparum ER - TY - JOUR T1 - Article: Macrophage and T Cell Dynamics during the Development and Disintegration of Mycobacterial Granulomas AN - 21045499; 8332178 AB - Granulomas play a key role in host protection against mycobacterial pathogens, with their breakdown contributing to exacerbated disease. To better understand the initiation and maintenance of these structures, we employed both high-resolution multiplex static imaging and intravital multiphoton microscopy of Mycobacterium bovis BCG-induced liver granulomas. We found that Kupffer cells directly capture blood-borne bacteria and subsequently nucleate formation of a nascent granuloma by recruiting both uninfected liver-resident macrophages and blood-derived monocytes. Within the mature granuloma, these myeloid cell populations formed a relatively immobile cellular matrix that interacted with a highly dynamic effector T cell population. The efficient recruitment of these T cells was highly dependent on TNF-derived signals, which also maintained the granuloma structure through preferential effects on uninfected macrophage populations. By characterizing the migration of both innate and adaptive immune cells throughout the process of granuloma development, these studies provide a new perspective on the cellular events involved in mycobacterial containment and escape. JF - Immunity AU - Egen, Jackson G AU - Rothfuchs, Antonio Gigliotti AU - Feng, Carl G AU - Winter, Nathalie AU - Sher, Alan AU - Germain, Ronald N AD - Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, asher@niaid.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 271 EP - 284 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 28 IS - 2 SN - 1074-7613, 1074-7613 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - CELLIMMUNO KW - HUMDISEASE KW - Macrophages KW - Mycobacterium bovis KW - Pathogens KW - Granuloma KW - Myeloid cells KW - imaging KW - Leukocyte migration KW - Blood KW - Kupffer cells KW - Microscopy KW - Lymphocytes T KW - Liver KW - Monocytes KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21045499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunity&rft.atitle=Article%3A+Macrophage+and+T+Cell+Dynamics+during+the+Development+and+Disintegration+of+Mycobacterial+Granulomas&rft.au=Egen%2C+Jackson+G%3BRothfuchs%2C+Antonio+Gigliotti%3BFeng%2C+Carl+G%3BWinter%2C+Nathalie%3BSher%2C+Alan%3BGermain%2C+Ronald+N&rft.aulast=Egen&rft.aufirst=Jackson&rft.date=2008-02-01&rft.volume=28&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Immunity&rft.issn=10747613&rft_id=info:doi/10.1016%2Fj.immuni.2007.12.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Leukocyte migration; Macrophages; Kupffer cells; Blood; Microscopy; Liver; Lymphocytes T; Pathogens; Monocytes; Myeloid cells; Granuloma; imaging; Mycobacterium bovis DO - http://dx.doi.org/10.1016/j.immuni.2007.12.010 ER - TY - JOUR T1 - Genomic Comparison of Virulent Rickettsia rickettsii Sheila Smith and Avirulent Rickettsia rickettsii Iowa AN - 21009263; 8037487 AB - Rickettsia rickettsii is an obligate intracellular pathogen that is the causative agent of Rocky Mountain spotted fever. To identify genes involved in the virulence of R. rickettsii, the genome of an avirulent strain, R. rickettsii Iowa, was sequenced and compared to the genome of the virulent strain R. rickettsii Sheila Smith. R. rickettsii Iowa is avirulent in a guinea pig model of infection and displays altered plaque morphology with decreased lysis of infected host cells. Comparison of the two genomes revealed that R. rickettsii Iowa and R. rickettsii Sheila Smith share a high degree of sequence identity. A whole-genome alignment comparing R. rickettsii Iowa to R. rickettsii Sheila Smith revealed a total of 143 deletions for the two strains. A subsequent single-nucleotide polymorphism (SNP) analysis comparing Iowa to Sheila Smith revealed 492 SNPs for the two genomes. One of the deletions in R. rickettsii Iowa truncates rompA, encoding a major surface antigen (rickettsial outer membrane protein A [rOmpA]) and member of the autotransporter family, 660 bp from the start of translation. Immunoblotting and immunofluorescence confirmed the absence of rOmpA from R. rickettsii Iowa. In addition, R. rickettsii Iowa is defective in the processing of rOmpB, an autotransporter and also a major surface antigen of spotted fever group rickettsiae. Disruption of rompA and the defect in rOmpB processing are most likely factors that contribute to the avirulence of R. rickettsii Iowa. Genomic differences between the two strains do not significantly alter gene expression as analysis of microarrays revealed only four differences in gene expression between R. rickettsii Iowa and R. rickettsii strain R. Although R. rickettsii Iowa does not cause apparent disease, infection of guinea pigs with this strain confers protection against subsequent challenge with the virulent strain R. rickettsii Sheila Smith. JF - Infection and Immunity AU - Ellison, Damon W AU - Clark, Tina R AU - Sturdevant, Daniel E AU - Virtaneva, Kimmo AU - Porcella, Stephen F AU - Hackstadt, Ted AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Genomics Unit, Research Technology Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 542 EP - 550 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 2 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Translation KW - Immunoblotting KW - outer membrane proteins KW - Animal models KW - Immunofluorescence KW - Pathogens KW - Infection KW - DNA microarrays KW - Virulence KW - Rocky Mountain spotted fever KW - Spotted fevers KW - surface antigens KW - Single-nucleotide polymorphism KW - Plaques KW - Rickettsia rickettsii KW - Sheila KW - genomics KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21009263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Genomic+Comparison+of+Virulent+Rickettsia+rickettsii+Sheila+Smith+and+Avirulent+Rickettsia+rickettsii+Iowa&rft.au=Ellison%2C+Damon+W%3BClark%2C+Tina+R%3BSturdevant%2C+Daniel+E%3BVirtaneva%2C+Kimmo%3BPorcella%2C+Stephen+F%3BHackstadt%2C+Ted&rft.aulast=Ellison&rft.aufirst=Damon&rft.date=2008-02-01&rft.volume=76&rft.issue=2&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Immunoblotting; Translation; outer membrane proteins; Animal models; Pathogens; Immunofluorescence; Infection; DNA microarrays; Virulence; Rocky Mountain spotted fever; Spotted fevers; Single-nucleotide polymorphism; surface antigens; Plaques; genomics; Sheila; Rickettsia rickettsii ER - TY - JOUR T1 - BEN: a novel domain in chromatin factors and DNA viral proteins AN - 20907161; 8035021 AB - We report a previously uncharacterized alpha -helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or transcription. Supplementary information: Supplementary data for this study can also be accessed at http://www.ncbi.nlm.nih.gov/CBBresearch/Lakshmin/BEN/ JF - Bioinformatics AU - Abhiman, Saraswathi AU - Iyer, Lakshminarayan M AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, aravind@ncbi.nlm.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 458 EP - 461 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 24 IS - 4 SN - 1367-4803, 1367-4803 KW - Entomology Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - DNA biosynthesis KW - Data processing KW - Chromatin KW - Replication KW - Food sources KW - DNA KW - Transcription KW - Bioinformatics KW - Drosophila KW - Protein interaction KW - N 14820:DNA Metabolism & Structure KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - V 22320:Replication KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20907161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=BEN%3A+a+novel+domain+in+chromatin+factors+and+DNA+viral+proteins&rft.au=Abhiman%2C+Saraswathi%3BIyer%2C+Lakshminarayan+M%3BAravind%2C+L&rft.aulast=Abhiman&rft.aufirst=Saraswathi&rft.date=2008-02-01&rft.volume=24&rft.issue=4&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Data processing; Chromatin; Replication; Food sources; DNA; Transcription; Bioinformatics; Protein interaction; Drosophila ER - TY - JOUR T1 - Altered Histone H1 Stoichiometry and an Absence of Nucleosome Positioning on Transfected DNA AN - 20901906; 8038616 AB - The packaging of DNA with histones to form chromatin represents an important and powerful mechanism to regulate gene expression. Critical aspects of chromatin-specific contributions to gene regulation have been revealed by the comparison of the activities from DNA regulatory elements examined both as transiently transfected reporters and stably integrated reporters organized as chromatin. Using the mouse mammary tumor virus (MMTV) promoter as a model, we probed the structural differences between transiently transfected and stably integrated DNA templates. We demonstrated that all four core histones and the linker histone (H1) are associated with the transient template. However, whereas the core histones were present at a similar stoichiometry between the transient and the stable templates, we found that linker histone H1 molecules are fewer on the transient template. By using supercoiling assay, we show that the transient template shows intermediate levels of nucleosomal assembly. Overexpression of H1 resulted in repression of MMTV transcriptional activity and reduced accessibility to restriction endonucleases on the transient MMTV promoter. However, the addition of exogenous H1 failed to impose a normal chromatin structure on the transient template as measured by micrococcal nuclease digestion pattern. Thus, our results suggest that while transiently transfected DNA acquires a full complement of core histones, the underrepresentation of H1 on the transient template is indicative of structural differences between the two templates that may underlie the differences in the mechanisms of activation of the two templates. JF - Journal of Biological Chemistry AU - Hebbar, Pratibha B AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 4595 EP - 4601 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 8 SN - 0021-9258, 0021-9258 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Chromatin KW - Regulatory sequences KW - Animal models KW - Nuclease KW - Promoters KW - Mouse mammary tumor virus KW - Nucleosomes KW - Supercoiling KW - Gene regulation KW - Complement activation KW - DNA KW - Endonuclease KW - Histone H1 KW - Packaging KW - Gene silencing KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20901906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Altered+Histone+H1+Stoichiometry+and+an+Absence+of+Nucleosome+Positioning+on+Transfected+DNA&rft.au=Hebbar%2C+Pratibha+B%3BArcher%2C+Trevor+K&rft.aulast=Hebbar&rft.aufirst=Pratibha&rft.date=2008-02-01&rft.volume=283&rft.issue=8&rft.spage=4595&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chromatin; Regulatory sequences; Animal models; Nuclease; Promoters; Nucleosomes; Supercoiling; Gene regulation; Complement activation; DNA; Endonuclease; Histone H1; Gene silencing; Packaging; Mouse mammary tumor virus ER - TY - JOUR T1 - Hormesis and disease resistance: activation of cellular stress response pathways AN - 20892790; 8334724 AB - The survival of all organisms depends upon their ability to overcome stressful conditions, an ability that involves adaptive changes in cells and molecules. Findings from studies of animal models and human populations suggest that hormesis (beneficial effects of low levels of stress) is an effective means of protecting against many different diseases including diabetes, cardiovascular disease, cancers and neurodegenerative disorders. Such stress resistance mechanisms can be bolstered by diverse environmental factors including exercise, dietary restriction, cognitive stimulation and exposure to low levels of toxins. Some commonly used vitamins and dietary supplements may also induce beneficial stress responses. Several interrelated cellular signaling molecules are involved in the process of hormesis. Examples include the gases oxygen, carbon monoxide and nitric oxide, the neurotransmitter glutamate, the calcium ion and tumor necrosis factor. In each case low levels of these signaling molecules are beneficial and protect against disease, whereas high levels can cause the dysfunction and/or death of cells. The cellular and molecular mechanisms of hormesis are being revealed and include activation of growth factor signaling pathways, protein chaperones, cell survival genes and enzymes called sirtuins. Knowledge of hormesis mechanisms is leading to novel approaches for preventing and treating a range of human diseases. JF - Human & Experimental Toxicology AU - Mattson, M P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA, mattsonm@grc.nia.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 155 EP - 162 VL - 27 IS - 2 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Cell survival KW - Molecular modelling KW - Calcium KW - Tumor necrosis factor KW - Animal models KW - Disease resistance KW - Environmental factors KW - Carbon monoxide KW - Vitamins KW - Neurotransmitters KW - Growth factors KW - Dietary restrictions KW - Stress KW - Enzymes KW - Toxins KW - Cancer KW - Physical training KW - Diabetes mellitus KW - Oxygen KW - Neurodegenerative diseases KW - Gases KW - hormesis KW - Cognitive ability KW - Dietary supplements KW - Chaperones KW - Nitric oxide KW - Cardiovascular diseases KW - Glutamic acid KW - Signal transduction KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20892790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Hormesis+and+disease+resistance%3A+activation+of+cellular+stress+response+pathways&rft.au=Mattson%2C+M+P&rft.aulast=Mattson&rft.aufirst=M&rft.date=2008-02-01&rft.volume=27&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327107083417 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Molecular modelling; Calcium; Tumor necrosis factor; Animal models; Disease resistance; Environmental factors; Carbon monoxide; Vitamins; Growth factors; Neurotransmitters; Dietary restrictions; Enzymes; Stress; Cancer; Toxins; Physical training; Diabetes mellitus; Neurodegenerative diseases; Oxygen; Gases; Cognitive ability; hormesis; Dietary supplements; Nitric oxide; Chaperones; Glutamic acid; Cardiovascular diseases; Signal transduction DO - http://dx.doi.org/10.1177/0960327107083417 ER - TY - JOUR T1 - Identification and Biological Characterization of Mouse beta -Defensin 14, the Orthologue of Human beta -Defensin 3 AN - 20865372; 8038700 AB - beta -Defensins are small antimicrobial polypeptides that are mainly expressed by epithelial cells and play an important role in the antimicrobial innate immune response. In addition to the direct microbicidal effects of these polypeptides, it became evident that certain members of the beta -defensin super family have the capacity to promote local innate inflammatory and systemic adaptive immune responses by interacting with the CC-chemokine receptor CCR6. We have identified mouse beta -defensin 14 (mBD14, Defb14) as an orthologue of human beta -defensin 3 (hBD3 or DEFB103). Based on primary structural analysis, mBD14 demonstrates greater (68%) homology to its human orthologue, containing three conserved cystein linkages, characteristic for the beta -defensin super family. mBD14 is expressed in a wide variety of tissues including spleen, colon, and tissues of the upper and lower respiratory tract. Interestingly, we also detected mBD14 expression in immature CD11c super(+) bone marrow-derived dendritic cells. The expression of mBD14 can be induced by Toll-like receptor agonists such as lipopolysaccharide and poly(I:C) and by pro-inflammatory stimuli e.g. tumor necrosis factor and interferon- gamma . Furthermore, expression of mBD14 seems to be regulated by activation of the intracellular pattern recognition receptor NOD2/CARD15 as revealed by reporter gene analysis. We prepared a recombinant mBD14-Ig fusion protein that retained potent antimicrobial activity against several Escherichia coli strains but not against various Gram-positive Staphylococcus aureus strains. hBD3 and also the newly identified mBD14 were chemotactic for cells expressing the mouse CC-chemokine receptor CCR6. In addition, both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3. JF - Journal of Biological Chemistry AU - Roehrl, Johann AU - Yang, De AU - Oppenheim, Joost J AU - Hehlgans, Thomas AD - Institute of Immunology University of Regensburg, D-93042 Regensburg, Germany and the Laboratory of Molecular Immunregulation, Division of Basic Science, NCI, National Institutes of Health, Frederick, Maryland 21702-1201 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 5414 EP - 5419 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 9 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Epithelial cells KW - Antimicrobial activity KW - CCR6 protein KW - Tumor necrosis factor KW - Bone marrow KW - CD11c antigen KW - Dendritic cells KW - Pattern recognition KW - Defensins KW - Colon KW - Structure-function relationships KW - Escherichia coli KW - Lipopolysaccharides KW - Staphylococcus aureus KW - Respiratory tract KW - NOD2 protein KW - Peritoneum KW - Spleen KW - Inflammation KW - Homology KW - Reporter gene KW - Immune response KW - Fusion protein KW - Toll-like receptors KW - microbicides KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20865372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Identification+and+Biological+Characterization+of+Mouse+beta+-Defensin+14%2C+the+Orthologue+of+Human+beta+-Defensin+3&rft.au=Roehrl%2C+Johann%3BYang%2C+De%3BOppenheim%2C+Joost+J%3BHehlgans%2C+Thomas&rft.aulast=Roehrl&rft.aufirst=Johann&rft.date=2008-02-01&rft.volume=283&rft.issue=9&rft.spage=5414&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; gamma -Interferon; Antimicrobial activity; NOD2 protein; Tumor necrosis factor; CCR6 protein; Peritoneum; Bone marrow; Spleen; CD11c antigen; Inflammation; Pattern recognition; Dendritic cells; Defensins; Homology; Colon; Structure-function relationships; Reporter gene; Lipopolysaccharides; Fusion protein; Immune response; Toll-like receptors; microbicides; Respiratory tract; Escherichia coli; Staphylococcus aureus ER - TY - JOUR T1 - DDE, a Degradation Product of DDT, and Duration of Lactation in a Highly Exposed Area of Mexico AN - 20863730; 8044935 AB - Background: Higher levels of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), the major degradation product of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), have been related to shorter duration of breast-feeding in previous studies. If DDE truly shortens lactation, this has public health importance regarding infant mortality and the use of DDT for malaria control. Objective: Our aim was to assess the relationship of maternal DDE concentrations with length of subsequent lactation. Methods: We conducted a relatively large study in a highly exposed area of Mexico. We followed 784 mother-son pairs to determine length of lactation. DDE and DDT were measured in maternal serum obtained within a day of delivery. We fit proportional hazard models with and without stratifying by previous breast-feeding, because an association of DDE with duration of lactation among those who breast-fed previously could be attributed to a noncausal mechanism. Results: Compared with those with DDE concentrations less than or equal to 3.00 mu g/g, the adjusted hazard ratios of weaning according to DDE category were, for concentrations 3.01-6.00 mu g/g, 1.27 [95% confidence interval (CI), 1.04-1.55]; for concentrations 6.01-9.00 mu g/g, 1.23 (95% CI, 0.92-1.63); and for concentrations > 9.00 mu g/g, 1.17 (95% CI, 0.92-1.49). The corresponding ratios for women who previously breast-fed were 1.40 (95% CI, 1.06-1.87); 1.91 (95% CI, 1.24-2.93); and 1.76 (95% CI, 1.22-2.53). Those for women who had not breast-fed previously were 1.14 (95% CI, 0.86-1.52); 0.90 (95% CI, 0.61-1.31); and 0.91 (95% CI, 0.66-1.26). Conclusions: Data from our relatively large study in a highly exposed area of Mexico did not support the hypothesis that exposure to DDE shortens length of lactation. The association seen in women who previously breast-fed was likely attributed to a noncausal mechanism. Nonetheless, whether DDT has other important adverse effects on humans is still an open question. JF - Environmental Health Perspectives AU - Cupul-Uicab, LA AU - Gladen, B C AU - Hernandez-Avila, M AU - Weber, J-P AU - Longnecker, M P AD - National Institute of Environmental Health Sciences, MD A3-05, PO Box 12233, Research Triangle Park, North Carolina 27709 USA, longnec1@niehs.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 179 EP - 183 VL - 116 IS - 2 SN - 0091-6765, 0091-6765 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Sustainability Science Abstracts; Toxicology Abstracts KW - Mortality KW - Data processing KW - infant mortality KW - DDE KW - Weaning KW - Malaria KW - Lactation KW - Public health KW - Models KW - Mexico KW - Insecticides KW - Nitrous oxide KW - malaria KW - DDT KW - Side effects KW - Degradation products KW - Infants KW - M3 1010:Issues in Sustainable Development KW - K 03400:Human Diseases KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20863730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=DDE%2C+a+Degradation+Product+of+DDT%2C+and+Duration+of+Lactation+in+a+Highly+Exposed+Area+of+Mexico&rft.au=Cupul-Uicab%2C+LA%3BGladen%2C+B+C%3BHernandez-Avila%2C+M%3BWeber%2C+J-P%3BLongnecker%2C+M+P&rft.aulast=Cupul-Uicab&rft.aufirst=LA&rft.date=2008-02-01&rft.volume=116&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10550 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; DDT; DDE; Weaning; Malaria; Side effects; Infants; Models; Public health; Degradation products; Lactation; Insecticides; infant mortality; Nitrous oxide; malaria; Mexico DO - http://dx.doi.org/10.1289/ehp.10550 ER - TY - JOUR T1 - ACUT2E TSE-SSFP: A hybrid method for T2-weighted imaging of edema in the heart AN - 20859374; 8368686 AB - ACUT2E TSE-SSFP is a hybrid between steady state free precession (SSFP) and turbo spin echo (TSE) for bright-blood T2-weighted imaging with signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) similar to dark-blood TSE. TSE-SSFP uses a segmented SSFP readout during diastole with 180DG pulses following a 90DG preparation. The 180DG refocusing pulses make TSE-SSFP similar to TSE but TSE-SSFP uses gradient moment nulling, whereas TSE uses gradient crushing. TSE-SSFP produced T2-weighted images with minimal T1 weighting. TSE-SSFP and TSE had similar SNR (155.9 - 6.0 vs 160.9 - 7.0; P = NS) for acute myocardial infarction (MI) and twice the SNR of T2-prepared SSFP (73.1 - 3.4, P < 0.001). TSE-SSFP and TSE had approximately double the CNR of T2-prepared SSFP for differentiating acute MI from normal myocardium. Imperfect blood suppression, present in all animals on some TSE images, was a problem eliminated by TSE-SSFP and T2-prepared SSFP. Magn Reson Med 59:229-235, 2008. JF - Magnetic Resonance in Medicine AU - Aletras, Anthony H AU - Kellman, Peter AU - Derbyshire, J Andrew AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland, aletrasa@nhlbi.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 229 EP - 235 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Blood KW - Hybrids KW - Edema KW - N.M.R. KW - imaging KW - Myocardial infarction KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=ACUT2E+TSE-SSFP%3A+A+hybrid+method+for+T2-weighted+imaging+of+edema+in+the+heart&rft.au=Aletras%2C+Anthony+H%3BKellman%2C+Peter%3BDerbyshire%2C+J+Andrew%3BArai%2C+Andrew+E&rft.aulast=Aletras&rft.aufirst=Anthony&rft.date=2008-02-01&rft.volume=59&rft.issue=2&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21490 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - imaging; Hybrids; N.M.R.; Blood; Myocardium; Myocardial infarction; Heart; Edema DO - http://dx.doi.org/10.1002/mrm.21490 ER - TY - JOUR T1 - Spectral simplification for resolved glutamate and glutamine measurement using a standard STEAM sequence with optimized timing parameters at 3, 4, 4.7, 7, and 9.4T AN - 20856673; 8368687 AB - The C4 multiplet proton resonances of glutamate (Glu) around 2.35 ppm and glutamine (Gln) around 2.45 ppm usually overlap in MR spectra, particularly at low- and mid-field strengths (1.5-4.7T). A spectral simplification approach is introduced that provides unobstructed Glu and Gln measurement using a standard STEAM localization sequence with optimized interpulse timings. The underlying idea is to exploit the dependence of response of a coupled spin system on the echo time (TE) and mixing time (TM) to find an optimum timing set (TE, TM), at which the outer-wings of C4 pseudo-triplet proton resonances of Glu and Gln are significantly suppressed while the central peaks are maintained. The spectral overlap is thus resolved as the overlap exists exclusively at the outer-wings and the central peaks are readily separated due to the approximate 0.1-ppm difference in chemical shift. Density matrix simulation for Glu, Gln, and other overlapping metabolites at 2.3-2.5 ppm was conducted to predict the optimum timing sets. The simulated, phantom, and in vivo results demonstrated that the C4 multiplet proton resonances of Glu and Gln can be resolved for unobstructed detection at 3T, 4T, and 4.7T. For simplicity, only simulated data are illustrated at 7T and 9.4T. Magn Reson Med 59:236-244, 2008. JF - Magnetic Resonance in Medicine AU - Yang, Shaolin AU - Hu, Jiani AU - Kou, Zhifeng AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, Maryland, yihongyang@intra.nida.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 236 EP - 244 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Glutamine KW - Data processing KW - Protons KW - Steam KW - Metabolites KW - N.M.R. KW - Glutamic acid KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Spectral+simplification+for+resolved+glutamate+and+glutamine+measurement+using+a+standard+STEAM+sequence+with+optimized+timing+parameters+at+3%2C+4%2C+4.7%2C+7%2C+and+9.4T&rft.au=Yang%2C+Shaolin%3BHu%2C+Jiani%3BKou%2C+Zhifeng%3BYang%2C+Yihong&rft.aulast=Yang&rft.aufirst=Shaolin&rft.date=2008-02-01&rft.volume=59&rft.issue=2&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21463 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Protons; Glutamic acid; Glutamine; Steam; N.M.R.; Data processing; Metabolites DO - http://dx.doi.org/10.1002/mrm.21463 ER - TY - JOUR T1 - Innate Immunity to Intraphagosomal Pathogens Is Mediated by Interferon Regulatory Factor 8 (IRF-8) That Stimulates the Expression of Macrophage-specific Nramp1 through Antagonizing Repression by c-Myc AN - 20846102; 8038421 AB - Macrophages are a central arm of innate immune defense against intracellular pathogens. They internalize microbes into phagosomes where the invaders are being killed by oxygen and nitrogen reactive species. Despite this battery of antimicrobial molecules, some are able to thrive within the phagosome thus termed intraphagosomal pathogens among which are Salmonella, Leishmania, and MYCOBACTERIA: In mice, a single dominant gene termed Nramp1/Slc11a1 controls innate resistance to such pathogens. This gene is expressed exclusively in myeloid cells. Previously, we have shown that the restricted expression of Nramp1 is regulated by a myeloid cell-specific transcription factor termed IRF-8/ICSBP. It is demonstrated here that the induction of Nramp1 expression in activated macrophages is accompanied by a promoter shift from a repression state elicited by c-Myc to an activation state elicited by the induction of IRF-8 in activated macrophages. This transition from repression to activation is facilitated by a competitive protein-protein interaction with the transcription factor Miz-1. To show that IRF-8 is directly involved in the elimination of intraphagosomal pathogens through the regulation of Nramp1 gene expression, we bred wild type as well as IRF-8 and Nramp1 null mouse strains and examined macrophages derived from bone marrow and peritoneum. Our results clearly show that the absence of IRF-8 and Nramp1 leads to the same phenotype; defective killing of intraphagosomal Salmonella enterica serovar typhimurium and Mycobacterium bovis. Thus, interplay between repression and activation state of the Nramp1 promoter mediated by IRF-8 provides the molecular basis by which macrophages resist intraphagosomal pathogens at early stage after infection. JF - Journal of Biological Chemistry AU - Alter-Koltunoff, Michal AU - Goren, Sigal AU - Nousbeck, Janna AU - Feng, Carl G AU - Sher, Alan AU - Ozato, Keiko AU - Azriel, Aviva AU - Levi, Ben-Zion AD - Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa 32000, Israel and the Laboratory of Molecular Growth Regulation, NICHD, and the Immunobiology Section, NIAID, National Institutes of Health Bethesda, Maryland 20892-8003 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 2724 EP - 2733 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 5 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Phagosomes KW - Peritoneum KW - Bone marrow KW - Mycobacterium bovis KW - Pathogens KW - Immunity KW - Infection KW - Myeloid cells KW - Cell activation KW - Leishmania KW - Promoters KW - Oxygen KW - Interferon regulatory factor KW - Salmonella enterica KW - Transcription factors KW - Nramp1 protein KW - Protein interaction KW - c-Myc protein KW - Nitrogen KW - K 03350:Immunology KW - N 14835:Protein-Nucleic Acids Association KW - J 02350:Immunology KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20846102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Innate+Immunity+to+Intraphagosomal+Pathogens+Is+Mediated+by+Interferon+Regulatory+Factor+8+%28IRF-8%29+That+Stimulates+the+Expression+of+Macrophage-specific+Nramp1+through+Antagonizing+Repression+by+c-Myc&rft.au=Alter-Koltunoff%2C+Michal%3BGoren%2C+Sigal%3BNousbeck%2C+Janna%3BFeng%2C+Carl+G%3BSher%2C+Alan%3BOzato%2C+Keiko%3BAzriel%2C+Aviva%3BLevi%2C+Ben-Zion&rft.aulast=Alter-Koltunoff&rft.aufirst=Michal&rft.date=2008-02-01&rft.volume=283&rft.issue=5&rft.spage=2724&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; Peritoneum; Phagosomes; Bone marrow; Immunity; Pathogens; Myeloid cells; Infection; Cell activation; Oxygen; Promoters; Interferon regulatory factor; Transcription factors; Nramp1 protein; c-Myc protein; Protein interaction; Nitrogen; Leishmania; Salmonella enterica; Mycobacterium bovis ER - TY - JOUR T1 - Structure and Catalytic Mechanism of Eukaryotic Selenocysteine Synthase AN - 20845889; 8038743 AB - In eukaryotes and Archaea, selenocysteine synthase (SecS) converts O-phospho-L-seryl-tRNA super([Ser]Sec) into selenocysteyl-tRNA super([Ser]Sec) using selenophosphate as the selenium donor compound. The molecular mechanisms underlying SecS activity are presently unknown. We have delineated a 450-residue core of mouse SecS, which retained full selenocysteyl-tRNA super([Ser]Sec) synthesis activity, and determined its crystal structure at 1.65Aa resolution. SecS exhibits three domains that place it in the fold type I family of pyridoxal phosphate (PLP)-dependent enzymes. Two SecS monomers interact intimately and together build up two identical active sites around PLP in a Schiff-base linkage with lysine 284. Two SecS dimers further associate to form a homotetramer. The N terminus, which mediates tetramer formation, and a large insertion that remodels the active site set SecS aside from other members of the family. The active site insertion contributes to PLP binding and positions a glutamate next to the PLP, where it could repel substrates with a free alpha -carboxyl group, suggesting why SecS does not act on free O-phospho-L-serine. Upon soaking crystals in phosphate buffer, a previously disordered loop within the active site insertion contracted to form a phosphate binding site. Residues that are strictly conserved in SecS orthologs but variant in related enzymes coordinate the phosphate and upon mutation corrupt SecS activity. Modeling suggested that the phosphate loop accommodates the gamma -phosphate moiety of O-phospho-L-seryl-tRNA super([Ser]Sec) and, after phosphate elimination, binds selenophosphate to initiate attack on the proposed aminoacrylyl-tRNA super([Ser]Sec) intermediate. Based on these results and on the activity profiles of mechanism-based inhibitors, we offer a detailed reaction mechanism for the enzyme. JF - Journal of Biological Chemistry AU - Ganichkin, Oleg M AU - Xu, Xue-Ming AU - Carlson, Bradley A AU - Mix, Heiko AU - Hatfield, Dolph L AU - Gladyshev, Vadim N AU - Wahl, Markus C AD - Max-Planck-Institut fuer Biophysikalische Chemie, Zellulaere Biochemie/Makromolekulare Roentgenkristallographie, Am Fassberg 11, D-37077 Goettingen, Germany, the Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, and the Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 5849 EP - 5865 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 9 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Molecular modelling KW - Archaea KW - selenophosphate KW - Selenocysteine KW - Lysine KW - Enzymes KW - Crystals KW - Monomers KW - Selenium KW - Reaction mechanisms KW - Phosphate KW - Crystal structure KW - Pyridoxal phosphate KW - Glutamic acid KW - Mutation KW - J 02330:Biochemistry KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20845889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Structure+and+Catalytic+Mechanism+of+Eukaryotic+Selenocysteine+Synthase&rft.au=Ganichkin%2C+Oleg+M%3BXu%2C+Xue-Ming%3BCarlson%2C+Bradley+A%3BMix%2C+Heiko%3BHatfield%2C+Dolph+L%3BGladyshev%2C+Vadim+N%3BWahl%2C+Markus+C&rft.aulast=Ganichkin&rft.aufirst=Oleg&rft.date=2008-02-01&rft.volume=283&rft.issue=9&rft.spage=5849&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; selenophosphate; Selenocysteine; Enzymes; Lysine; Crystals; Monomers; Selenium; Reaction mechanisms; Phosphate; Crystal structure; Pyridoxal phosphate; Glutamic acid; Mutation; Archaea ER - TY - JOUR T1 - Psychiatric Disorders in Clinical Genetics I: Addressing Family Histories of Psychiatric Illness AN - 20844729; 8156414 AB - This is the first article of a two-part professional development series addressing genetic counseling for personal and family histories of psychiatric disorders. It is based on an Educational Breakout Session presented by the Psychiatric Special Interest Group of the National Society of Genetic Counselors at the 2006 Annual Education Conference. This article examines issues that arise in addressing family histories of psychiatric illness, while the second article in the series considers the generation and provision of individualized recurrence risks for psychiatric disorders. In this article we discuss the importance of managing uncertainty for affected individuals and their close family members who have been referred to genetics for a number of different indications. We then use four simulated cases to make recommendations about the scope and timing of discussions related to the psychiatric family history. JF - Journal of Genetic Counseling AU - Peay, Holly L AU - Veach, Patricia McCarthy AU - Palmer, Christina GS AU - Rosen-Sheidley, Beth AU - Gettig, Elizabeth AU - Austin, Jehannine C AD - NHGRI, NIH, 31 Center Drive Building 31 B1B36H MSC 2073, Bethesda, MD, 20892, USA, hpeay@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 6 EP - 17 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 17 IS - 1 SN - 1059-7700, 1059-7700 KW - Genetics Abstracts; Risk Abstracts KW - Education KW - Mental disorders KW - Conferences KW - genetic screening KW - interest groups KW - G 07730:Development & Cell Cycle KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20844729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Psychiatric+Disorders+in+Clinical+Genetics+I%3A+Addressing+Family+Histories+of+Psychiatric+Illness&rft.au=Peay%2C+Holly+L%3BVeach%2C+Patricia+McCarthy%3BPalmer%2C+Christina+GS%3BRosen-Sheidley%2C+Beth%3BGettig%2C+Elizabeth%3BAustin%2C+Jehannine+C&rft.aulast=Peay&rft.aufirst=Holly&rft.date=2008-02-01&rft.volume=17&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-007-9120-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mental disorders; Conferences; Education; genetic screening; interest groups DO - http://dx.doi.org/10.1007/s10897-007-9120-5 ER - TY - JOUR T1 - Identification of Novel Toxicity-associated Metabolites by Metabolomics and Mass Isotopomer Analysis of Acetaminophen Metabolism in Wild-type and Cyp2e1-null Mice AN - 20808136; 8038611 AB - CYP2E1 is recognized as the most important enzyme for initiation of acetaminophen (APAP)-induced toxicity. In this study, the resistance of Cyp2e1-null mice to APAP treatment was confirmed by comparing serum aminotransferase activities and blood urea nitrogen levels in wild-type and Cyp2e1-null mice. However, unexpectedly, profiling of major known APAP metabolites in urine and serum revealed that the contribution of CYP2E1 to APAP metabolism decreased with increasing APAP doses administered. Measurement of hepatic glutathione and hydrogen peroxide levels exposed the importance of oxidative stress in determining the consequence of APAP overdose. Subsequent metabolomic analysis was capable of constructing a principal components analysis (PCA) model that delineated a relationship between urinary metabolomes and the responses to APAP treatment. Urinary ions high in wild-type mice treated with 400 mg/kg APAP were elucidated as 3-methoxy-APAP glucuronide (VII) and three novel APAP metabolites, including S-(5-acetylamino-2-hydroxyphenyl)mercaptopyruvic acid (VI, formed by a Cys-APAP transamination reaction in kidney), 3,3'-biacetaminophen (VIII, an APAP dimer), and a benzothiazine compound (IX, originated from deacetylated APAP), through mass isotopomer analysis, accurate mass measurement, tandem mass spectrometry fragmentation, in vitro reactions, and chemical treatments. Dose-, time-, and genotype-dependent appearance of these minor APAP metabolites implied their association with the APAP-induced toxicity and potential biomarker application. Overall, the oxidative stress elicited by CYP2E1-mediated APAP metabolism might significantly contribute to APAP-induced toxicity. The combination of genetically modified animal models, mass isotopomer analysis, and metabolomics provides a powerful and efficient technical platform to characterize APAP-induced toxicity through identifying novel biomarkers and unraveling novel mechanisms. JF - Journal of Biological Chemistry AU - Chen, Chi AU - Krausz, Kristopher W AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 and the Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 12800 Prague, Czech Republic Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 4543 EP - 4559 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 8 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Ions KW - Glutathione KW - Animal models KW - Enzymes KW - Urea KW - Metabolites KW - Toxicity KW - biomarkers KW - Mass spectroscopy KW - Blood KW - Overdose KW - Oxidative stress KW - Hydrogen peroxide KW - Urine KW - Principal components analysis KW - Kidney KW - Liver KW - Acetaminophen KW - metabolomics KW - Nitrogen KW - X 24310:Pharmaceuticals KW - G 07870:Mammals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20808136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Identification+of+Novel+Toxicity-associated+Metabolites+by+Metabolomics+and+Mass+Isotopomer+Analysis+of+Acetaminophen+Metabolism+in+Wild-type+and+Cyp2e1-null+Mice&rft.au=Chen%2C+Chi%3BKrausz%2C+Kristopher+W%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Chen&rft.aufirst=Chi&rft.date=2008-02-01&rft.volume=283&rft.issue=8&rft.spage=4543&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ions; Glutathione; Animal models; Enzymes; Metabolites; Urea; Toxicity; biomarkers; Mass spectroscopy; Blood; Overdose; Urine; Hydrogen peroxide; Oxidative stress; Principal components analysis; Liver; Kidney; metabolomics; Acetaminophen; Nitrogen ER - TY - JOUR T1 - Neurochemical mechanisms for development of psychological dependence on volatile organic solvents AN - 20767049; 8192250 AB - Abuse of volatile organic solvents among youth remains a major social problem. Organic solvents are cheap and relatively easy to obtain, so they carry the risk of becoming a "gateway drug" for users. The effect of repeated inhalation of toluene on subsequent responses to other drugs of abuse is unclear. In the present study, we investigated the effect of toluene inhalation on methamphetamine-induced behavioral change using a newly developed sealed inhalation shuttlebox. The influence of the cyclic AMP response element binding (CREB) protein expression following toluene inhalation was also examined. Mice were exposed to toluene or air once daily for five days. Methamphetamine produced significant hyperlocomotion in air-exposed mice. This stimulatory effect of methamphetamine was significantly enhanced following repeated inhalation of toluene. Furthermore, repeated toluene inhalation increased the levels of CREB proteins in the limbic forebrain. The present study demonstrated that adaptation of the adenylate cyclase system following repeated toluene inhalation might be involved in the expression of behavioral sensi-tization to subsequent methamphetamine administration. Inhalant abuse could thus be associated with the risk of other substances of abuse. JF - Japanese Journal of Neuropsychopharmacology AU - Funada, M AU - Aoo, N AU - Wada, K AD - Department of Drug Dependence, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo, 187-8553 Japan Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 7 EP - 10 VL - 28 IS - 1 SN - 1340-2544, 1340-2544 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Inhalation KW - Adaptations KW - Toluene KW - Regulatory sequences KW - Solvents KW - Drug abuse KW - Forebrain KW - Methamphetamine KW - Inhalants KW - Volatiles KW - Cyclic AMP response element-binding protein KW - Adenylate cyclase KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20767049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+Journal+of+Neuropsychopharmacology&rft.atitle=Neurochemical+mechanisms+for+development+of+psychological+dependence+on+volatile+organic+solvents&rft.au=Funada%2C+M%3BAoo%2C+N%3BWada%2C+K&rft.aulast=Funada&rft.aufirst=M&rft.date=2008-02-01&rft.volume=28&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Japanese+Journal+of+Neuropsychopharmacology&rft.issn=13402544&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inhalation; Forebrain; Inhalants; Methamphetamine; Adaptations; Volatiles; Regulatory sequences; Toluene; Solvents; Drug abuse; Adenylate cyclase; Cyclic AMP response element-binding protein ER - TY - JOUR T1 - Assessment of Interactions between PAH Exposure and Genetic Polymorphisms on PAH-DNA Adducts in African American, Dominican, and Caucasian Mothers and Newborns AN - 20762564; 8035971 AB - Polycyclic aromatic hydrocarbons (PAH) are widespread pollutants commonly found in air, food, and drinking water. Benzo[a]pyrene is a well-studied representative PAH found in air from fossil fuel combustion and a transplacental carcinogen experimentally. PAHs bind covalently to DNA to form DNA adducts, an indicator of DNA damage, and an informative biomarker of potential cancer risk. Associations between PAH-DNA adduct levels and both cancer risk and developmental deficits have been seen in previous experimental and epidemiologic studies. Several genes have been shown to play an important role in the metabolic activation or detoxification of PAHs, including the cytochrome P450 genes CYP1A1 and CYP1B1 and the glutathione S-transferase (GST) genes GSTM1, and GSTT2. Genetic variation in these genes could influence susceptibility to adverse effects of PAHs in polluted air. Here, we have explored interactions between prenatal PAH exposure and 17 polymorphisms in these genes (rs2198843, rs1456432, rs4646903, rs4646421, rs2606345, rs7495708, rs2472299, rs162549, rs1056837, rs1056836, rs162560, rs10012, rs2617266, rs2719, rs1622002, rs140194, and gene deletion GSTM1-02) and haplotypes on PAH-DNA adducts in cord blood of 547 newborns and in maternal blood of 806 mothers from three different self-described ethnic groups: African Americans, Dominicans, and Caucasians. PAHs were measured by personal air monitoring of mothers during pregnancy. Significant interactions (p < 0.05) were observed between certain genetic polymorphisms and CYP1A1 haplotype and PAHs in mothers and their newborns in the three ethnic groups. However, with our limited sample size, the current findings are suggestive only, warranting further study. (Cancer Epidemiol Biomarkers Prev 2008; 17(2):405-13) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Wang, Shuang AU - Chanock, Stephen AU - Tang, Deliang AU - Li, Zhigang AU - Jedrychowski, Wieslaw AU - Perera, Frederica P AD - Department of Biostatistics and Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, New York, New York and National Cancer Institute, Bethesda, Maryland Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 405 EP - 413 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 2 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Detoxification KW - Prenatal experience KW - Food KW - Gene polymorphism KW - Genetic diversity KW - Carcinogens KW - Glutathione transferase KW - Cord blood KW - GSTM1 protein KW - Gene deletion KW - Pollutants KW - Haplotypes KW - Ethnic groups KW - DNA adducts KW - Polycyclic aromatic hydrocarbons KW - Fossil fuels KW - biomarkers KW - Cancer KW - Combustion KW - Pregnancy KW - DNA damage KW - Metabolic activation KW - Benzo(a)pyrene KW - Cytochrome P450 KW - Neonates KW - Drinking water KW - Side effects KW - N 14820:DNA Metabolism & Structure KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20762564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Assessment+of+Interactions+between+PAH+Exposure+and+Genetic+Polymorphisms+on+PAH-DNA+Adducts+in+African+American%2C+Dominican%2C+and+Caucasian+Mothers+and+Newborns&rft.au=Wang%2C+Shuang%3BChanock%2C+Stephen%3BTang%2C+Deliang%3BLi%2C+Zhigang%3BJedrychowski%2C+Wieslaw%3BPerera%2C+Frederica+P&rft.aulast=Wang&rft.aufirst=Shuang&rft.date=2008-02-01&rft.volume=17&rft.issue=2&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Detoxification; Prenatal experience; Gene polymorphism; Food; Genetic diversity; Carcinogens; Glutathione transferase; Cord blood; Gene deletion; GSTM1 protein; Haplotypes; Pollutants; Ethnic groups; DNA adducts; Polycyclic aromatic hydrocarbons; Fossil fuels; biomarkers; Cancer; Pregnancy; Combustion; DNA damage; Metabolic activation; Benzo(a)pyrene; Neonates; Cytochrome P450; Drinking water; Side effects ER - TY - JOUR T1 - Birth weight and risk of testicular cancer AN - 20728285; 8079957 AB - Abstract not available. JF - International Journal of Cancer AU - Cook, Michael B AU - Richiardi, Lorenzo AU - McGlynn, Katherine A AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, cookmich@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 957 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 122 IS - 4 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - birth weight KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20728285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Birth+weight+and+risk+of+testicular+cancer&rft.au=Cook%2C+Michael+B%3BRichiardi%2C+Lorenzo%3BMcGlynn%2C+Katherine+A&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2008-02-01&rft.volume=122&rft.issue=4&rft.spage=957&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23129 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cancer; birth weight DO - http://dx.doi.org/10.1002/ijc.23129 ER - TY - JOUR T1 - Dichlorvos exposure and human cancer risk: results from the Agricultural Health Study AN - 20727882; 8150077 AB - Objectives: We evaluated cancer risk from DDVP (2,2-Dichloroethenyl dimethylphosphate) exposure among pesticide applicators enrolled in the Agricultural Health Study (AHS) cohort. Methods: The AHS is a cohort of 57,311 pesticide applicators in North Carolina and Iowa, enrolled from 1993 to 1997 and followed for cancer through 2004. A comprehensive questionnaire collected information on exposure to DDVP and potential confounders. Among the 49,762 licensed pesticide applicators eligible for analysis, 4,613 reported use of DDVP. DDVP exposure was classified as intensity-weighted cumulative exposure days (IWED), calculated as [years of use x days per year x intensity level]. Poisson regression analysis was used to calculate rate ratios (RR) and 95% confidence intervals (CI) to evaluate the association of DDVP exposure among 2,943 incident cases of cancer. Results: DDVP exposure was not associated with any cancer studied here. We observed no elevation in risk among lymphohematopoietic cancers, RR = 1.00 (95% CI 0.51, 1.96) and a small excess risk associated with exposure among those with a family history of prostate cancer (RR = 1.18 (95% CI 0.73, 1.82). Conclusion: We find little evidence of an association between cumulative lifetime use of DDVP and risk of any cancer at this stage of follow up of the AHS. JF - Cancer Causes & Control AU - Koutros, Stella AU - Mahajan, Rajeev AU - Zheng, Tongzhang AU - Hoppin, Jane A AU - Ma, Xiaomei AU - Lynch, Charles F AU - Blair, Aaron AU - Alavanja, Michael CR AD - National Cancer Institute, 6120 Executive Blvd., Rockville, MD, 20852, USA, koutross@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 59 EP - 65 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 19 IS - 1 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Toxicology Abstracts KW - USA, North Carolina KW - Inventories KW - dichlorvos KW - Cancer KW - Genetics KW - Prostate cancer KW - USA, Iowa KW - Pesticides KW - Regression analysis KW - prostate cancer KW - Dichlorvos KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Dichlorvos+exposure+and+human+cancer+risk%3A+results+from+the+Agricultural+Health+Study&rft.au=Koutros%2C+Stella%3BMahajan%2C+Rajeev%3BZheng%2C+Tongzhang%3BHoppin%2C+Jane+A%3BMa%2C+Xiaomei%3BLynch%2C+Charles+F%3BBlair%2C+Aaron%3BAlavanja%2C+Michael+CR&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2008-02-01&rft.volume=19&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-9070-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Prostate cancer; Pesticides; Regression analysis; Dichlorvos; Genetics; dichlorvos; prostate cancer; Cancer; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1007/s10552-007-9070-0 ER - TY - JOUR T1 - Violent Behavior and DSM-IV Psychiatric Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions AN - 20709959; 8208934 AB - Objective: To present nationally representative data on the lifetime prevalence and population estimates of violent behavior among individuals with DSM-IV psychiatric disorders. Method: The data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions. Prevalences, population estimates, and associations of violent behavior occurring among individuals with pure, comor-bid, and specific DSM-IV psychiatric disorders we re examined. Results: After controlling for sociodemo-graphic characteristics and other comorbidity, it was found that the odds of violent behavior were significantly increased (p < .05) among individuals with substance use disorders; pathological gambling; major depressive disorder; bipolar dis-orders; panic disorder without agoraphobia; spe-cific phobia; and paranoid, schizoid, histrionic, and obsessive-compulsive personality disorders. Percentages of violent behavior among individ-uals with each comorbid disorder were, with few exceptions, significantly greater (p < .05-p < .001) than the corresponding percentages among those presenting with the pure form of each disorder. Alcohol and drug use disorders were the most significant contributors to the public health burden of violent behavior. Conclusion: The majority of individuals with psychiatric disorders do not engage in vio-lent behavior, and public perception associated with stereotypic violence among individuals with psychiatric disorders appears unwarranted. Elevated risks and burden of violent behavior were not equally shared across the spectrum of psychiatric disorders, with particular disorders, especially substance use disorders, contributing disproportionately to the burden. Future research should examine the circumstances under which violence among individuals with psychiatric dis-orders occurs with a view toward improving clinical prediction and developing more effective prevention strategies. JF - Journal of Clinical Psychiatry AU - Pulay, A J AU - Dawson, DA AU - Hasin, D S AU - Goldstein, R B AU - Ruan, W J AU - Pickering, R P AU - Huang, B AU - Chou, S P AU - Grant, B F AD - Laboratory of Epidemiology and Biometry, Room 3077, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, M.S. 9304,5635 Fishers Lane, Bethesda, MD 20892-9304, USA, bgrant@willco.niaaa.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 12 EP - 22 VL - 69 IS - 2 SN - 0160-6689, 0160-6689 KW - Risk Abstracts KW - Drug abuse KW - personality KW - Morbidity KW - Public health KW - prevention KW - Alcohol KW - substance use KW - Violence KW - gambling KW - Behavior KW - Perception KW - mental disorders KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20709959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychiatry&rft.atitle=Violent+Behavior+and+DSM-IV+Psychiatric+Disorders%3A+Results+From+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Pulay%2C+A+J%3BDawson%2C+DA%3BHasin%2C+D+S%3BGoldstein%2C+R+B%3BRuan%2C+W+J%3BPickering%2C+R+P%3BHuang%2C+B%3BChou%2C+S+P%3BGrant%2C+B+F&rft.aulast=Pulay&rft.aufirst=A&rft.date=2008-02-01&rft.volume=69&rft.issue=2&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - mental disorders; Alcohol; Violence; substance use; Public health; gambling; Perception; Morbidity; personality; prevention; Drug abuse; Behavior ER - TY - JOUR T1 - Development of a Microtiter Plate Hybridization-Based PCR-Enzyme-Linked Immunosorbent Assay for Identification of Clinically Relevant Human Group A Rotavirus G and P Genotypes AN - 20707297; 8039125 AB - A microtiter plate hybridization-based PCR-enzyme-linked immunosorbent assay (PCR-ELISA) has been used for the detection and identification of a variety of microorganisms. Here, we report the development of a PCR-ELISA for the identification of clinically relevant human rotavirus VP7 (G1 to G6, G8 to G10, and G12) and VP4 (P[4], P[6], P[8], P[9], and P[14]) genotypes. The G and P types of reference human and animal rotavirus strains for which specific probes were available were correctly identified by the PCR-ELISA. In addition, reference strains bearing G or P genotypes for which specific probes were unavailable, such as G11, G14, P[3], P[10], and P[11], did not display any cross-reactivity to the probes. The usefulness of the assay was further evaluated by analyzing a total of 396 rotavirus-positive stool samples collected in four countries: Brazil, Ghana, Japan, and the United States. The results of this study showed that the PCR-ELISA was sensitive and easy to perform without the use of any expensive and sophisticated equipment, the reagents used are easy to obtain commercially and advantageous over multiplex PCR since more than one type-specific probe is used and the selection of probes is more flexible. JF - Journal of Clinical Microbiology AU - Santos, Norma AU - Honma, Shinjiro AU - Timenetsky, Maria do Carmo ST AU - Linhares, Alexandre C AU - Ushijima, Hiroshi AU - Armah, George E AU - Gentsch, Jon R AU - Hoshino, Yasutaka AD - Instituto de Microbiologia, UFRJ, Rio de Janeiro, Brazil. Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland. Instituto Adolfo Lutz, Sao Paulo, Brazil. Instituto Evandro Chagas, Secretaria de Vigilancia em Saude, Belem, Brazil. University of Tokyo, Tokyo, Japan. Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, CDC, Atlanta, Georgia Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 462 EP - 469 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 2 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Rotavirus KW - Cross-reactivity KW - Human rotavirus KW - Probes KW - Microorganisms KW - Polymerase chain reaction KW - Genotypes KW - Feces KW - Group a rotavirus KW - Immunosorbents KW - V 22400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20707297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Development+of+a+Microtiter+Plate+Hybridization-Based+PCR-Enzyme-Linked+Immunosorbent+Assay+for+Identification+of+Clinically+Relevant+Human+Group+A+Rotavirus+G+and+P+Genotypes&rft.au=Santos%2C+Norma%3BHonma%2C+Shinjiro%3BTimenetsky%2C+Maria+do+Carmo+ST%3BLinhares%2C+Alexandre+C%3BUshijima%2C+Hiroshi%3BArmah%2C+George+E%3BGentsch%2C+Jon+R%3BHoshino%2C+Yasutaka&rft.aulast=Santos&rft.aufirst=Norma&rft.date=2008-02-01&rft.volume=46&rft.issue=2&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cross-reactivity; Microorganisms; Probes; Polymerase chain reaction; Genotypes; Feces; Immunosorbents; Rotavirus; Human rotavirus; Group a rotavirus ER - TY - JOUR T1 - Lon protease promotes survival of Escherichia coli during anaerobic glucose starvation AN - 20595795; 8152657 AB - In Escherichia coli, Lon is an ATP-dependent protease which degrades misfolded proteins and certain rapidly-degraded regulatory proteins. Given that oxidatively damaged proteins are generally degraded rather than repaired, we anticipated that Lon deficient cells would exhibit decreased viability during aerobic, but not anaerobic, carbon starvation. We found that the opposite actually occurs. Wild-type and Lon deficient cells survived equally well under aerobic conditions, but Lon deficient cells died more rapidly than the wild-type under anaerobiosis. Aerobic induction of the Clp family of ATP-dependent proteases could explain these results, but direct quantitation of Clp protein established that its level was not affected by Lon deficiency and overexpression of Clp did not rescue the cells under anaerobic conditions. We conclude that the Lon protease supports survival during anaerobic carbon starvation by a mechanism which does not depend on Clp. JF - Archives of Microbiology AU - Luo, Shen AU - McNeill, Megan AU - Myers, Timothy G AU - Hohman, Robert J AU - Levine, Rodney L AD - National Heart, Lung, and Blood Institute, NIH, Building 50, Room 2351, Bethesda, MD, 20892-8012, USA, rlevine@nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 181 EP - 185 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 189 IS - 2 SN - 0302-8933, 0302-8933 KW - Microbiology Abstracts B: Bacteriology KW - Starvation KW - Clp protein KW - Aerobic conditions KW - Lon protein KW - Glucose KW - Anaerobic conditions KW - Carbon KW - Protein folding KW - regulatory proteins KW - Escherichia coli KW - Proteinase KW - Quantitation KW - Anaerobiosis KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20595795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Microbiology&rft.atitle=Lon+protease+promotes+survival+of+Escherichia+coli+during+anaerobic+glucose+starvation&rft.au=Luo%2C+Shen%3BMcNeill%2C+Megan%3BMyers%2C+Timothy+G%3BHohman%2C+Robert+J%3BLevine%2C+Rodney+L&rft.aulast=Luo&rft.aufirst=Shen&rft.date=2008-02-01&rft.volume=189&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Archives+of+Microbiology&rft.issn=03028933&rft_id=info:doi/10.1007%2Fs00203-007-0304-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Clp protein; Starvation; Aerobic conditions; Carbon; regulatory proteins; Protein folding; Lon protein; Glucose; Proteinase; Anaerobic conditions; Quantitation; Anaerobiosis; Escherichia coli DO - http://dx.doi.org/10.1007/s00203-007-0304-z ER - TY - JOUR T1 - Low-Level Neonatal Thimerosal Exposure: Further Evaluation of Altered Neurotoxic Potential in SJL Mice AN - 20566983; 8043208 AB - Ethylmercury in thimerosal-preserved childhood vaccines has been suggested to be neurotoxic and to contribute to the etiology of neurodevelopmental disorders, including autism. Immune system function may be an important factor influencing vulnerability of the developing nervous system to thimerosal. This possibility is based in part on a report by Hornig et al. (2004, Mol. Psychiatry 9, 833-845) of neurodevelomental toxicity in SJL/J mice that develop autoantibodies when exposed to organic mercury. The present study reexamined this possibility by injecting neonatal SJL/J mice with thimerosal, with and without combined HiB and DTP vaccines. Injections modeled childhood vaccination schedules, with mice injected on postnatal days 7, 9, 11, and 15 with 14.2, 10.8, 9.2, and 5.6 mu g/kg mercury from thimerosal, respectively, or vehicle. Additional groups received vaccine only or a 10 times higher thimerosal + vaccine dose. Low levels of mercury were found in blood, brain, and kidneys 24 h following the last thimerosal injection. Survival, body weight, indices of early development (negative geotaxis, righting) and hippocampal morphology were not affected. Performance was unaffected in behavioral tests selected to assess behavioral domains relevant to core deficits in neurodevelopmental disorders such as autism (i.e., social interaction, sensory gating, anxiety). In an open-field test the majority of behaviors were unaffected by thimerosal injection, although thimerosal-injected female mice showed increased time in the margin of an open field at 4 weeks of age. Considered together the present results do not indicate pervasive developmental neurotoxicity following vaccine-level thimerosal injections in SJL mice, and provide little if any support for the hypothesis that thimerosal exposure contributes to the etiology of neurodevelopmental disorders. JF - Toxicological Sciences AU - Berman, Robert F AU - Pessah, Isaac N AU - Mouton, Peter R AU - Mav, Deepak AU - Harry, Jean AD - Department of Neurological Surgery and the Center for Children's Environmental Health. Center for Children's Environmental Health and Department of Molecular Biosciences, University of California Davis, California 95616. Laboratory of Experimental Gerontology NIA/NIH, Baltimore, Maryland 21224. Constella Group, LLC, Durham, North Carolina 27713. Neurotoxicology Group, Laboratory of Neurobiology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 294 EP - 309 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 101 IS - 2 SN - 1096-6080, 1096-6080 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - thimerosal KW - Neurodevelopmental disorders KW - Pertussis KW - Age KW - Anxiety KW - Hippocampus KW - Immune system KW - Survival KW - Tetanus KW - Nervous system KW - Body weight KW - Combined vaccines KW - Geotaxis KW - Etiology KW - Diphtheria KW - Children KW - Social interactions KW - Blood KW - Autoantibodies KW - Gating KW - Neurotoxicity KW - Kidney KW - Mercury KW - Vaccines KW - Neonates KW - Autism KW - Psychiatry KW - N3 11028:Neuropharmacology & toxicology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20566983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Low-Level+Neonatal+Thimerosal+Exposure%3A+Further+Evaluation+of+Altered+Neurotoxic+Potential+in+SJL+Mice&rft.au=Berman%2C+Robert+F%3BPessah%2C+Isaac+N%3BMouton%2C+Peter+R%3BMav%2C+Deepak%3BHarry%2C+Jean&rft.aulast=Berman&rft.aufirst=Robert&rft.date=2008-02-01&rft.volume=101&rft.issue=2&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neurodevelopmental disorders; thimerosal; Pertussis; Age; Anxiety; Hippocampus; Immune system; Survival; Tetanus; Nervous system; Body weight; Combined vaccines; Geotaxis; Etiology; Diphtheria; Children; Social interactions; Blood; Autoantibodies; Gating; Neurotoxicity; Kidney; Mercury; Neonates; Vaccines; Psychiatry; Autism ER - TY - JOUR T1 - Adeno-Associated Virus Type 12 (AAV12): a Novel AAV Serotype with Sialic Acid- and Heparan Sulfate Proteoglycan-Independent Transduction Activity AN - 20562717; 8040548 AB - Recombinant adeno-associated virus (rAAV) is a promising vector for gene therapy. Recent isolations of novel AAV serotypes have led to significant advances by broadening the tropism and increasing the efficiency of gene transfer to the desired target cell. However, a major concern that remains is the strong preexisting immune responses to several vectors. In this paper, we describe the isolation and characterization of AAV12, an AAV serotype with unique biological and immunological properties. In contrast to those of all other reported AAVs, AAV12 cell attachment and transduction do not require cell surface sialic acids or heparan sulfate proteoglycans. Furthermore, rAAV12 is resistant to neutralization by circulating antibodies from human serum. The feasibility of rAAV12 as a vector was demonstrated in a mouse model in which muscle and salivary glands were transduced. These characteristics make rAAV12 an interesting candidate for gene transfer applications. JF - Journal of Virology AU - Schmidt, Michael AU - Voutetakis, Antonis AU - Afione, Sandra AU - Zheng, Changyu AU - Mandikian, Danielle AU - Chiorini, John A AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 1399 EP - 1406 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 82 IS - 3 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Cell surface KW - Serotypes KW - Gene therapy KW - Tropism KW - Muscles KW - Animal models KW - Salivary gland KW - Adeno-associated virus KW - Cell adhesion KW - Expression vectors KW - Antibodies KW - Heparan sulfate proteoglycans KW - Sialic acids KW - W 30905:Medical Applications KW - V 22350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20562717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Adeno-Associated+Virus+Type+12+%28AAV12%29%3A+a+Novel+AAV+Serotype+with+Sialic+Acid-+and+Heparan+Sulfate+Proteoglycan-Independent+Transduction+Activity&rft.au=Schmidt%2C+Michael%3BVoutetakis%2C+Antonis%3BAfione%2C+Sandra%3BZheng%2C+Changyu%3BMandikian%2C+Danielle%3BChiorini%2C+John+A&rft.aulast=Schmidt&rft.aufirst=Michael&rft.date=2008-02-01&rft.volume=82&rft.issue=3&rft.spage=1399&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Expression vectors; Cell surface; Antibodies; Serotypes; Gene therapy; Tropism; Animal models; Muscles; Salivary gland; Heparan sulfate proteoglycans; Sialic acids; Cell adhesion; Adeno-associated virus ER - TY - JOUR T1 - caCORE version 3: Implementation of a model driven, service-oriented architecture for semantic interoperability AN - 20542808; 8097227 AB - One of the requirements for a federated information system is interoperability, the ability of one computer system to access and use the resources of another system. This feature is particularly important in biomedical research systems, which need to coordinate a variety of disparate types of data. In order to meet this need, the National Cancer Institute Center for Bioinformatics (NCICB) has created the cancer Common Ontologic Representation Environment (caCORE), an interoperability infrastructure based on Model Driven Architecture. The caCORE infrastructure provides a mechanism to create interoperable biomedical information systems. Systems built using the caCORE paradigm address both aspects of interoperability: the ability to access data (syntactic interoperability) and understand the data once retrieved (semantic interoperability). This infrastructure consists of an integrated set of three major components: a controlled terminology service (Enterprise Vocabulary Services), a standards-based metadata repository (the cancer Data Standards Repository) and an information system with an Application Programming Interface (API) based on Domain Model Driven Architecture. This infrastructure is being leveraged to create a Semantic Service-Oriented Architecture (SSOA) for cancer research by the National Cancer Institute's cancer Biomedical Informatics Grid (caBIG(TM)). JF - Journal of Biomedical Informatics AU - Komatsoulis, G A AU - Warzel, D B AU - Hartel, F W AU - Shanbhag, K AU - Chilukuri, R AU - Fragoso, G AU - Coronado, Sd AU - Reeves, D M AU - Hadfield, J B AU - Ludet, C AU - Covitz, P A AD - 2115 E. Jefferson St., Suite 5000, Rockville, MD 20852, USA, komatsog@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 106 EP - 123 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 41 IS - 1 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Computers KW - Bioinformatics KW - Cancer KW - Information systems KW - Semantics KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20542808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=caCORE+version+3%3A+Implementation+of+a+model+driven%2C+service-oriented+architecture+for+semantic+interoperability&rft.au=Komatsoulis%2C+G+A%3BWarzel%2C+D+B%3BHartel%2C+F+W%3BShanbhag%2C+K%3BChilukuri%2C+R%3BFragoso%2C+G%3BCoronado%2C+Sd%3BReeves%2C+D+M%3BHadfield%2C+J+B%3BLudet%2C+C%3BCovitz%2C+P+A&rft.aulast=Komatsoulis&rft.aufirst=G&rft.date=2008-02-01&rft.volume=41&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2007.03.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Computers; Bioinformatics; Cancer; Models; Semantics; Information systems DO - http://dx.doi.org/10.1016/j.jbi.2007.03.009 ER - TY - JOUR T1 - Resistance of Porphyromonas gingivalis ATCC 33277 to Direct Killing by Antimicrobial Peptides Is Protease Independent AN - 20541366; 8032643 AB - Antimicrobial peptides are short, positively charged, amphipathic peptides that possess a wide spectrum of antimicrobial activity and have an important role in the host's innate immunity. Lack of, or dysfunctions in, antimicrobial peptides have been correlated with infectious diseases, including periodontitis. Porphyromonas gingivalis, a gram-negative anaerobe and a major pathogen associated with periodontal diseases, is resistant to antimicrobial peptides of human and nonhuman origin, a feature that likely contributes to its virulence. Expressing a robust proteolytic activity, P. gingivalis hydrolyzes antimicrobial peptides. In this study, P. gingivalis inactivated three antimicrobial peptides, while a D-enantiomer was resistant to degradation. P. gingivalis was resistant to the protease-resistant D-enantiomer peptide, and importantly, a protease-deficient P. gingivalis mutant was also resistant to the antimicrobial peptide. Finally, the binding of a fluorescently labeled antimicrobial peptide to protease-deficient P. gingivalis was much weaker than the binding of susceptible Escherichia coli. Our results suggest that the resistance of P. gingivalis ATCC 33277 to direct killing by antimicrobial peptides is protease independent and results (at least partially) from the low affinity of antimicrobial peptides to P. gingivalis. JF - Antimicrobial Agents & Chemotherapy AU - Bachrach, Gilad AU - Altman, Hamutal AU - Kolenbrander, Paul E AU - Chalmers, Natalia I AU - Gabai-Gutner, Michal AU - Mor, Amram AU - Friedman, Michael AU - Steinberg, Doron AD - Institute of Dental Sciences, The Hebrew University-Hadassah School of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, Bethesda, Maryland 20892. Laboratory of Antimicrobial Peptides Investigation, Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology Haifa, Haifa, Israel. Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 638 EP - 642 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Proteolysis KW - Antimicrobial activity KW - Porphyromonas gingivalis KW - Pathogens KW - Immunity KW - Virulence KW - Periodontal diseases KW - Infectious diseases KW - Periodontitis KW - Escherichia coli KW - Proteinase KW - Antimicrobial peptides KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20541366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Resistance+of+Porphyromonas+gingivalis+ATCC+33277+to+Direct+Killing+by+Antimicrobial+Peptides+Is+Protease+Independent&rft.au=Bachrach%2C+Gilad%3BAltman%2C+Hamutal%3BKolenbrander%2C+Paul+E%3BChalmers%2C+Natalia+I%3BGabai-Gutner%2C+Michal%3BMor%2C+Amram%3BFriedman%2C+Michael%3BSteinberg%2C+Doron&rft.aulast=Bachrach&rft.aufirst=Gilad&rft.date=2008-02-01&rft.volume=52&rft.issue=2&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Periodontal diseases; Virulence; Proteolysis; Antimicrobial activity; Infectious diseases; Periodontitis; Proteinase; Immunity; Pathogens; Antimicrobial peptides; Porphyromonas gingivalis; Escherichia coli ER - TY - JOUR T1 - A Meta-analysis of the Effects of Oral Zinc in the Treatment of Acute and Persistent Diarrhea AN - 20537418; 8041829 AB - OBJECTIVE. Children in developing countries are at a high risk for zinc deficiency. Supplemental zinc has previously been shown to provide therapeutic benefits in diarrhea. The objective of this study was to examine the efficacy and safety of supplemental oral zinc therapy during recovery from acute or persistent diarrhea. METHODS. We conducted a meta-analysis of randomized, controlled trials to compare the efficacy and safety of supplementary oral zinc with placebo in children with acute and persistent diarrhea. Results were reported using a pooled relative risk or a weighted mean difference. A total of 22 studies were identified for inclusion: 16 examined acute diarrhea (n = 15231), and 6 examined persistent diarrhea (n = 2968). RESULTS. Mean duration of acute diarrhea and persistent diarrhea was significantly lower for zinc compared with placebo. Presence of diarrhea between zinc and placebo at day 1 was not significantly different in acute diarrhea or persistent diarrhea trials. At day 3, presence was significantly lower for zinc in persistent diarrhea trials (n = 221) but not in acute diarrhea trials. Vomiting after therapy was significantly higher for zinc in 11 acute diarrhea trials (n = 4438) and 4 persistent diarrhea trials (n = 2969). Those who received zinc gluconate in comparison with zinc sulfate/acetate vomited more frequently. Overall, children who received zinc reported an 18.8% and 12.5% reduction in average stool frequency, 15.0% and 15.5% shortening of diarrhea duration, and a 17.9% and 18.0% probability of reducing diarrhea over placebo in acute and persistent trials, respectively. CONCLUSIONS. Zinc supplementation reduces the duration and severity of acute and persistent diarrhea; however, the mechanisms by which zinc exerts its antidiarrheal effect have not been fully elucidated. JF - Pediatrics AU - Lukacik, Marek AU - Thomas, Ronald L AU - Aranda, Jacob V AD - Department of Pediatrics, Children's Medical Center, Medical College of Georgia, Augusta, Georgia. Department of Pediatrics, Wayne State University School of Medicine, and Children's Hospital of Michigan, Detroit, Michigan, and National Institute of Child Health and Human Development, Pediatric Pharmacology Research Unit Network, Wayne State University, Detroit, Michigan Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 326 EP - 336 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 121 IS - 2 SN - 0031-4005, 0031-4005 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Sulfates KW - clinical trials KW - Zinc KW - Children KW - Gastrointestinal tract KW - Developing countries KW - Side effects KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20537418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=A+Meta-analysis+of+the+Effects+of+Oral+Zinc+in+the+Treatment+of+Acute+and+Persistent+Diarrhea&rft.au=Lukacik%2C+Marek%3BThomas%2C+Ronald+L%3BAranda%2C+Jacob+V&rft.aulast=Lukacik&rft.aufirst=Marek&rft.date=2008-02-01&rft.volume=121&rft.issue=2&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Zinc; Children; clinical trials; Gastrointestinal tract; Side effects; Sulfates; Developing countries ER - TY - JOUR T1 - Can Proton MR Spectroscopic and Perfusion Imaging Differentiate Between Neoplastic and Nonneoplastic Brain Lesions in Adults? AN - 20536176; 8032975 AB - BACKGROUND: AND PURPOSE: Noninvasive diagnosis of brain lesions is important for the correct choice of treatment. Our aims were to investigate whether 1) proton MR spectroscopic imaging ( super(1)H-MRSI) can aid in differentiating between tumors and nonneoplastic brain lesions, and 2) perfusion MR imaging can improve the classification. MATERIALS AND METHODS: We retrospectively examined 69 adults with untreated primary brain lesions (brain tumors, n = 36; benign lesions, n = 10; stroke, n = 4; demyelination, n = 10; and stable lesions not confirmed on pathologic examination, n = 9). MR imaging and super(1)H-MRSI were performed at 1.5T before biopsy or treatment. Concentrations of N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) in the lesion were expressed as metabolite ratios and were normalized to the contralateral hemisphere. Dynamic susceptibility contrast-enhanced perfusion MR imaging was performed in a subset of patients (n = 32); relative cerebral blood volume (rCBV) was evaluated. Discriminant function analysis was used to identify variables that can predict inclusion in the neoplastic or nonneoplastic lesion groups. Receiver operator characteristic (ROC) analysis was used to compare the discriminatory capability of super(1)H-MRSI and perfusion MR imaging. RESULTS: The discriminant function analysis correctly classified 84.2% of original grouped cases (P < .0001), on the basis of NAA/Cho, Cho sub(norm), NAA sub(norm), and NAA/Cr ratios. MRSI and perfusion MR imaging had similar discriminatory capabilities in differentiating tumors from nonneoplastic lesions. With cutoff points of NAA/Cho less than or equal to 0.61 and rCBV greater than or equal to 1.50 (corresponding to diagnosis of the tumors), a sensitivity of 72.2% and specificity of 91.7% in differentiating tumors from nonneoplastic lesions were achieved. CONCLUSION: These results suggest a promising role for super(1)H-MRSI and perfusion MR imaging in the distinction between brain tumors and nonneoplastic lesions in adults. JF - American Journal of Neuroradiology AU - Hourani, R AU - Brant, L J AU - Rizk, T AU - Weingart, J D AU - Barker, P B AU - Horska, A AD - Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, Md. Department of Neurological Surgery, Johns Hopkins Hospital, Baltimore, Md. National Institutes of Health/National Institute on Aging, Gerontology Research Center, Baltimore, Md. Department of Radiology, American University of Beirut Medical Center, Beirut, Lebanon. Department of Neurosurgery, Hotel Dieu Hospital, Beirut, Lebanon. FM Kirby Research Center, Kennedy Krieger Institute, Baltimore, Md Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 366 EP - 372 PB - American Society of Neuroradiology, 2210 Midwest Rd. Ste. 207 Oak Brood IL 60521 USA, [mailto:ajnr@interaccess.com] VL - 29 IS - 2 SN - 0195-6108, 0195-6108 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Choline KW - Neuroimaging KW - Magnetic resonance imaging KW - N-^AAcetylaspartate KW - Creatine KW - Metabolites KW - Biopsy KW - Demyelination KW - Classification KW - Benign KW - Perfusion KW - Protons KW - Stroke KW - N-Acetylaspartate KW - Brain tumors KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20536176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Neuroradiology&rft.atitle=Can+Proton+MR+Spectroscopic+and+Perfusion+Imaging+Differentiate+Between+Neoplastic+and+Nonneoplastic+Brain+Lesions+in+Adults%3F&rft.au=Hourani%2C+R%3BBrant%2C+L+J%3BRizk%2C+T%3BWeingart%2C+J+D%3BBarker%2C+P+B%3BHorska%2C+A&rft.aulast=Hourani&rft.aufirst=R&rft.date=2008-02-01&rft.volume=29&rft.issue=2&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Neuroradiology&rft.issn=01956108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Perfusion; Magnetic resonance imaging; Brain tumors; Neuroimaging; Protons; Biopsy; Creatine; Stroke; Classification; Cerebral blood flow; Demyelination; N-Acetylaspartate; Metabolites; Choline; Benign; N-^AAcetylaspartate ER - TY - JOUR T1 - High-density mapping of single-molecule trajectories with photoactivated localization microscopy AN - 20532422; 8026664 AB - We combined photoactivated localization microscopy (PALM) with live-cell single-particle tracking to create a new method termed sptPALM. We created spatially resolved maps of single-molecule motions by imaging the membrane proteins Gag and VSVG, and obtained several orders of magnitude more trajectories per cell than traditional single-particle tracking enables. By probing distinct subsets of molecules, sptPALM can provide insight into the origins of spatial and temporal heterogeneities in membranes. JF - Nature Methods AU - , AU - Manley, Suliana AU - Gillette, Jennifer M AU - Patterson, George H AU - Shroff, Hari AU - Hess, Harald F AU - Betzig, Eric AU - Lippincott-Schwartz, Jennifer AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA., jlippin@helix.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 155 EP - 157 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 5 IS - 2 SN - 1548-7091, 1548-7091 KW - Biotechnology and Bioengineering Abstracts KW - Microscopy KW - Membrane proteins KW - imaging KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20532422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Methods&rft.atitle=High-density+mapping+of+single-molecule+trajectories+with+photoactivated+localization+microscopy&rft.au=%2C%3BManley%2C+Suliana%3BGillette%2C+Jennifer+M%3BPatterson%2C+George+H%3BShroff%2C+Hari%3BHess%2C+Harald+F%3BBetzig%2C+Eric%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=&rft.aufirst=&rft.date=2008-02-01&rft.volume=5&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Nature+Methods&rft.issn=15487091&rft_id=info:doi/10.1038%2Fnmeth.1176 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Microscopy; imaging; Membrane proteins DO - http://dx.doi.org/10.1038/nmeth.1176 ER - TY - JOUR T1 - Inhibitor-complexed Structures of the Cytochrome bc sub(1) from the Photosynthetic Bacterium Rhodobacter sphaeroides AN - 20531685; 8038433 AB - The cytochrome bc sub(1) complex (bc sub(1)) is a major contributor to the proton motive force across the membrane by coupling electron transfer to proton translocation. The crystal structures of wild type and mutant bc sub(1) complexes from the photosynthetic purple bacterium Rhodobacter sphaeroides (Rsbc sub(1)), stabilized with the quinol oxidation (Q sub(P)) site inhibitor stigmatellin alone or in combination with the quinone reduction (Q sub(N)) site inhibitor antimycin, were determined. The high quality electron density permitted assignments of a new metal-binding site to the cytochrome c sub(1) subunit and a number of lipid and detergent molecules. Structural differences between Rsbc sub(1) and its mitochondrial counterparts are mostly extra membranous and provide a basis for understanding the function of the predominantly longer sequences in the bacterial subunits. Functional implications for the bc sub(1) complex are derived from analyses of 10 independent molecules in various crystal forms and from comparisons with mitochondrial complexes. JF - Journal of Biological Chemistry AU - Esser, Lothar AU - Elberry, Maria AU - Zhou, Fei AU - Yu, Chang-An AU - Yu, Linda AU - Xia, Di AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 and the Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma 74078 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 2846 EP - 2857 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 5 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Rhodobacter sphaeroides KW - Detergents KW - Protons KW - Lipids KW - Mitochondria KW - Crystals KW - Electron transfer KW - cytochrome c1 KW - Cytochrome bc1 KW - quinol KW - Oxidation KW - Quinone KW - Crystal structure KW - Translocation KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Inhibitor-complexed+Structures+of+the+Cytochrome+bc+sub%281%29+from+the+Photosynthetic+Bacterium+Rhodobacter+sphaeroides&rft.au=Esser%2C+Lothar%3BElberry%2C+Maria%3BZhou%2C+Fei%3BYu%2C+Chang-An%3BYu%2C+Linda%3BXia%2C+Di&rft.aulast=Esser&rft.aufirst=Lothar&rft.date=2008-02-01&rft.volume=283&rft.issue=5&rft.spage=2846&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protons; Detergents; Lipids; Mitochondria; Crystals; Electron transfer; cytochrome c1; Cytochrome bc1; quinol; Quinone; Oxidation; Crystal structure; Translocation; Rhodobacter sphaeroides ER - TY - JOUR T1 - An antidote for Staphylococcus aureus pneumonia? AN - 20531190; 8039268 AB - Methicillin-resistant Staphylococcus aureus (MRSA) is the leading cause of bacterial infections in the United States. Severe invasive MRSA infections, which include pneumonia, are difficult to treat because the bacteria are resistant to antibiotics. A new report now shows that immunization against alpha -hemolysin (Hla), a cytolytic toxin secreted by most S. aureus strains, protects mice against lethal pneumonia. This finding represents the first successful vaccine strategy for the treatment of staphylococcal pneumonia. JF - Journal of Experimental Medicine AU - DeLeo, Frank R AU - Otto, Michael AD - F.R. DeLeo and M. Otto are at the Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 271 EP - 274 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 205 IS - 2 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Histocompatibility antigen HLA KW - Drug resistance KW - Antibiotics KW - Vaccines KW - Staphylococcus aureus KW - Infection KW - Pneumonia KW - Toxins KW - Immunization KW - Antidotes KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=An+antidote+for+Staphylococcus+aureus+pneumonia%3F&rft.au=DeLeo%2C+Frank+R%3BOtto%2C+Michael&rft.aulast=DeLeo&rft.aufirst=Frank&rft.date=2008-02-01&rft.volume=205&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Drug resistance; Antibiotics; Vaccines; Infection; Immunization; Toxins; Pneumonia; Antidotes; Staphylococcus aureus ER - TY - JOUR T1 - Is There Room for Improvement in Adverse Event Reporting in the Era of Targeted Therapies? AN - 20530292; 8039985 AB - The Common Terminology Criteria for Adverse Events (CTCAE), version 3.0, and its predecessors, the Common Toxicity Criteria (CTC) versions 1.0 and 2.0, were developed under the direction of the Cancer Therapy Evaluation Program of the National Cancer Institute (NCI) in an effort to provide standard language for reporting adverse events that occur in NCI-sponsored clinical trials. Each successive version of the CTC has improved the accuracy, precision, and completeness of the criteria in an effort to standardize reporting. We believe that the current version of the CTCAE cannot adequately code the subacute adverse events that commonly occur with todays targeted therapies. JF - Journal of the National Cancer Institute AU - Edgerly, Maureen AU - Fojo, Tito AD - Center for Cancer Research, National Cancer Institute, Bethesda, MD Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 240 EP - 242 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 100 IS - 4 SN - 0027-8874, 0027-8874 KW - Health & Safety Science Abstracts KW - Toxicity KW - clinical trials KW - Side effects KW - Cancer KW - H 14000:Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20530292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Is+There+Room+for+Improvement+in+Adverse+Event+Reporting+in+the+Era+of+Targeted+Therapies%3F&rft.au=Edgerly%2C+Maureen%3BFojo%2C+Tito&rft.aulast=Edgerly&rft.aufirst=Maureen&rft.date=2008-02-01&rft.volume=100&rft.issue=4&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Side effects; Toxicity; clinical trials ER - TY - JOUR T1 - Transcription Profiling of the Stringent Response in Escherichia coli AN - 20528424; 8038097 AB - The bacterial stringent response serves as a paradigm for understanding global regulatory processes. It can be triggered by nutrient downshifts or starvation and is characterized by a rapid RelA-dependent increase in the alarmone (p)ppGpp. One hallmark of the response is the switch from maximum-growth-promoting to biosynthesis-related gene expression. However, the global transcription patterns accompanying the stringent response in Escherichia coli have not been analyzed comprehensively. Here, we present a time series of gene expression profiles for two serine hydroxymate-treated cultures: (i) MG1655, a wild-type E. coli K-12 strain, and (ii) an isogenic relA Delta 251 derivative defective in the stringent response. The stringent response in MG1655 develops in a hierarchical manner, ultimately involving almost 500 differentially expressed genes, while the relA Delta 251 mutant response is both delayed and limited in scope. We show that in addition to the down-regulation of stable RNA-encoding genes, flagellar and chemotaxis gene expression is also under stringent control. Reduced transcription of these systems, as well as metabolic and transporter-encoding genes, constitutes much of the down-regulated expression pattern. Conversely, a significantly larger number of genes are up-regulated. Under the conditions used, induction of amino acid biosynthetic genes is limited to the leader sequences of attenuator-regulated operons. Instead, up-regulated genes with known functions, including both regulators (e.g., rpoE, rpoH, and rpoS) and effectors, are largely involved in stress responses. However, one-half of the up-regulated genes have unknown functions. How these results are correlated with the various effects of (p)ppGpp (in particular, RNA polymerase redistribution) is discussed. JF - Journal of Bacteriology AU - Durfee, Tim AU - Hansen, Anne-Marie AU - Zhi, Huijun AU - Blattner, Frederick R AU - Jin, Ding Jun AD - Department of Genetics, University of Wisconsin, Madison, Wisconsin 53706. Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute-Frederick, National Institutes of Health, Frederick, Maryland 21702 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 1084 EP - 1096 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 3 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Stringent response KW - Starvation KW - Transcription KW - Stress KW - Nutrients KW - Chemotaxis KW - Gene expression KW - DNA-directed RNA polymerase KW - Escherichia coli KW - Operons KW - Serine KW - Flagella KW - J 02320:Cell Biology KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20528424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Transcription+Profiling+of+the+Stringent+Response+in+Escherichia+coli&rft.au=Durfee%2C+Tim%3BHansen%2C+Anne-Marie%3BZhi%2C+Huijun%3BBlattner%2C+Frederick+R%3BJin%2C+Ding+Jun&rft.aulast=Durfee&rft.aufirst=Tim&rft.date=2008-02-01&rft.volume=190&rft.issue=3&rft.spage=1084&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Starvation; Gene expression; Stringent response; DNA-directed RNA polymerase; Stress; Transcription; Nutrients; Operons; Chemotaxis; Serine; Flagella; Escherichia coli ER - TY - JOUR T1 - Resistance of Yersinia pestis to Complement-Dependent Killing Is Mediated by the Ail Outer Membrane Protein AN - 20528022; 8037494 AB - Yersinia pestis, the causative agent of plague, must survive in blood in order to cause disease and to be transmitted from host to host by fleas. Members of the Ail/Lom family of outer membrane proteins provide protection from complement-dependent killing for a number of pathogenic bacteria. The Y. pestis KIM genome is predicted to encode four Ail/Lom family proteins. Y. pestis mutants specifically deficient in expression of each of these proteins were constructed using lambda Red-mediated recombination. The Ail outer membrane protein was essential for Y. pestis to resist complement-mediated killing at 26 and 37 degree C. Ail was expressed at high levels at both 26 and 37 degree C, but not at 6 degree C. Expression of Ail in Escherichia coli provided protection from the bactericidal activity of complement. High-level expression of the three other Y. pestis Ail/Lom family proteins (the y1682, y2034, and y2446 proteins) provided no protection against complement-mediated bacterial killing. A Y. pestis ail deletion mutant was rapidly killed by sera obtained from all mammals tested except mouse serum. The role of Ail in infection of mice, Caenorhabditis elegans, and fleas was investigated. JF - Infection and Immunity AU - Bartra, Sara Schesser AU - Styer, Katie L AU - O'Bryant, Deanna M AU - Nilles, Matthew L AU - Hinnebusch, BJoseph AU - Aballay, Alejandro AU - Plano, Gregory V AD - Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida 33101. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710. Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202. Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, NIH, NIAID, Hamilton, Montana 59840. Department of Molecular Biology, Umeaa University, 901 87 Umeaa, Sweden Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 612 EP - 622 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 2 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Genomes KW - outer membrane proteins KW - Deletion mutant KW - Complement KW - Yersinia pestis KW - Infection KW - Blood KW - Recombination KW - Caenorhabditis elegans KW - Escherichia coli KW - Plague KW - Bactericidal activity KW - F 06910:Microorganisms & Parasites KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20528022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Resistance+of+Yersinia+pestis+to+Complement-Dependent+Killing+Is+Mediated+by+the+Ail+Outer+Membrane+Protein&rft.au=Bartra%2C+Sara+Schesser%3BStyer%2C+Katie+L%3BO%27Bryant%2C+Deanna+M%3BNilles%2C+Matthew+L%3BHinnebusch%2C+BJoseph%3BAballay%2C+Alejandro%3BPlano%2C+Gregory+V&rft.aulast=Bartra&rft.aufirst=Sara&rft.date=2008-02-01&rft.volume=76&rft.issue=2&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Recombination; Blood; Deletion mutant; outer membrane proteins; Complement; Plague; Infection; Bactericidal activity; Caenorhabditis elegans; Escherichia coli; Yersinia pestis ER - TY - JOUR T1 - VEGF Facilitates Periosteal Distraction-Induced Osteogenesis in Rabbits: A Micro-Computerized Tomography Study AN - 20490637; 8045451 AB - Background and purpose: Distraction osteogenesis is routinely used for reconstruction of bone. Conversely, it was hypothesized that mechanical traction of the periosteum would induce bone formation, and hence the use of periosteal distraction for induction of osteogenesis has been proposed. Further, it was postulated that intracallus administration of vascular endothelial growth factor (VEGF) would facilitate osteogenesis. To investigate this hypothesis, formation of newly synthesized bone was evaluated using micro-computerized tomography ( mu CT) and histomorphometry. Materials and methods: Periosteal distractors were placed subperiosteally in one side of the mandible of rabbits, whereas the contralateral served as control. One group of animals received VEGF into the forming callus. Formation of bone was measured using mu CT and histological analysis. Results: The results demonstrate formation of new bone following periosteal distraction. Addition of VEGF to the distraction site increased bone synthesis. Conclusions: mu CT and histologicai analysis validate the hypothesis that mechanical distraction of the periosteum induces osteogenesis and that VEGF has a positive effect on osteogenesis. Periosteal distraction is emerging as a reliable technique for bone regeneration. JF - Tissue Engineering AU - Casap, N AU - Venezia, N B AU - Wilensky, A AU - Samuni, Y AD - Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel, ysamuni@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 247 EP - 253 VL - 14 IS - 2 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - Reconstruction KW - Bone histomorphometry KW - Bone growth KW - Callus KW - Tissue engineering KW - Mandible KW - Periosteum KW - Regeneration KW - Tomography KW - Distraction osteogenesis KW - Attention KW - Osteogenesis KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20490637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering&rft.atitle=VEGF+Facilitates+Periosteal+Distraction-Induced+Osteogenesis+in+Rabbits%3A+A+Micro-Computerized+Tomography+Study&rft.au=Casap%2C+N%3BVenezia%2C+N+B%3BWilensky%2C+A%3BSamuni%2C+Y&rft.aulast=Casap&rft.aufirst=N&rft.date=2008-02-01&rft.volume=14&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ftea.2007.0069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Bone growth; Tomography; Bone histomorphometry; Periosteum; Tissue engineering; Callus; Osteogenesis; Attention; Reconstruction; Distraction osteogenesis; Regeneration; Mandible DO - http://dx.doi.org/10.1089/tea.2007.0069 ER - TY - JOUR T1 - Driving miles estimates by teen drivers: how accurate are they? AN - 20490108; 8037589 AB - The objective of this study was to determine how accurately teens can report miles driven. Participants were 118 drivers in Connecticut (average age 17 one half years; average time licensed 11 months). Half had their own vehicle; half shared family vehicles. Teens completed a telephone survey about their preceding week's driving, then completed a daily trip log for the next week and a second survey about the details of the logged week's trips and miles. Teens with their own vehicle provided odometer readings. Summing the miles for every trip was generally consistent with estimates from odometer readings. Overall mileage estimates were 20-30% lower than those from trip-by-trip listings, except for very low estimates for the first week by teens who shared vehicles. The results indicate that single overall estimates frequently understate total miles driven, but that prompted reviews of each trip can provide valid and detailed information. JF - Injury Prevention AU - Leaf, W A AU - Simons-Morton, B G AU - Hartos, J L AU - Northrup, V Shabanova AD - Preusser Research Group, Inc., Trumbull, CT, USA National Institute of Child Health and Human Development, Bethesda, MD, USA University of North Carolina - Charlotte, NC, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 59 EP - 61 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 14 IS - 1 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20490108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Driving+miles+estimates+by+teen+drivers%3A+how+accurate+are+they%3F&rft.au=Leaf%2C+W+A%3BSimons-Morton%2C+B+G%3BHartos%2C+J+L%3BNorthrup%2C+V+Shabanova&rft.aulast=Leaf&rft.aufirst=W&rft.date=2008-02-01&rft.volume=14&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Development of inhibitors of ATP-binding cassette drug transporters - present status and challenges AN - 20366728; 9050513 AB - Background: Multi-drug resistance (MDR) of cancer cells is an obstacle to effective chemotherapy of cancer. The ATP-binding cassette (ABC) transporters, including P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2, play an important role in the development of this resistance. An attractive approach to overcoming MDR is the inhibition of the pumping action of these transporters. Several inhibitors/modulators of ABC transporters have been developed, but cytotoxic effects and adverse pharmacokinetics have prohibited their use. The ongoing search for such inhibitors/modulators that can be applied in the clinic has led to three generations of compounds. The most recent inhibitors are more potent and less toxic than first-generation compounds, yet some are still prone to adverse effects, poor solubility and unfavorable changes in the pharmacokinetics of the anticancer drugs. Objective: This review provides an update of the published work on the development of potent modulators to overcome MDR in cancer cells, their present status in clinical studies and suggestions for further improvement to obtain better inhibitors. Methods: This review summarizes recent advances in the development of less toxic modulators, including small molecules and natural products. In addition, a brief overview of other novel approaches that can be used to inhibit ABC drug transporters mediating MDR has also been provided. Conclusion: The multifactorial nature of MDR indicates that it may be important to develop modulators that can simultaneously inhibit both the function of the drug transporters and key signaling pathways, which are responsible for development of this phenomenon. JF - Expert Opinion on Drug Metabolism and Toxicology AU - Shukla, Suneet AU - Wu, Chung-Pu AU - Ambudkar, Suresh V AD - National Cancer Institute, NIH, Laboratory of Cell Biology, Center for Cancer Research, Bethesda, MD 20892, USA +1 301 402 4178; ambudkar@ helix.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 205 EP - 223 PB - Informa Healthcare VL - 4 IS - 2 SN - 1742-5255, 1742-5255 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - ATP-binding cassette transporter KW - ATP hydrolysis KW - cancer chemotherapy KW - chemosensitizers KW - clinical trials KW - MRP1 KW - multi-drug resistance KW - natural product modulators KW - P-glycoprotein KW - Solubility KW - ABC transporter KW - Chemotherapy KW - natural products KW - Drug development KW - chemotherapy KW - Pharmacokinetics KW - Cancer KW - Cytotoxicity KW - P-Glycoprotein KW - Reviews KW - Multidrug resistance KW - Drugs KW - Metabolism KW - Side effects KW - Signal transduction KW - X 24310:Pharmaceuticals KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20366728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.atitle=Development+of+inhibitors+of+ATP-binding+cassette+drug+transporters+-+present+status+and+challenges&rft.au=Shukla%2C+Suneet%3BWu%2C+Chung-Pu%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2008-02-01&rft.volume=4&rft.issue=2&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.4.2.205 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Solubility; ABC transporter; Chemotherapy; Drug development; natural products; Cancer; Pharmacokinetics; P-Glycoprotein; Cytotoxicity; Reviews; Multidrug resistance; Drugs; Side effects; Signal transduction; Metabolism; chemotherapy DO - http://dx.doi.org/10.1517/17425255.4.2.205 ER - TY - JOUR T1 - iNOS activity is critical for the clearance of Burkholderia mallei from infected RAW 264.7 murine macrophages AN - 20354942; 9031454 AB - Burkholderia mallei is a facultative intracellular pathogen that can cause fatal disease in animals and humans. To better understand the role of phagocytic cells in the control of infections caused by this organism, studies were initiated to examine the interactions of B. mallei with RAW 264.7 murine macrophages. Utilizing modified kanamycin-protection assays, B. mallei was shown to survive and replicate in RAW 264.7 cells infected at multiplicities of infection (moi) of , 1. In contrast, the organism was efficiently cleared by the macrophages when infected at an moi of 10. Interestingly, studies demonstrated that the monolayers only produced high levels of TNF-a, IL-6, IL-10, GM-CSF, RANTES and IFN-b when infected at an moi of 10. In addition, nitric oxide assays and inducible nitric oxide synthase (iNOS) immunoblot analyses revealed a strong correlation between iNOS activity and clearance of B. mallei from RAW 264.7 cells. Furthermore, treatment of activated macrophages with the iNOS inhibitor, aminoguanidine, inhibited clearance of B. mallei from infected monolayers. Based upon these results, it appears that moi significantly influence the outcome of interactions between B. mallei and murine macrophages and that iNOS activity is critical for the clearance of B. mallei from activated RAW 264.7 cells. JF - Cellular Microbiology AU - Brett, Paul J AU - Burtnick, Mary N AU - Su, Hua AU - Nair, Vinod AU - Gherardini, Frank C AD - Laboratory of Zoonotic Pathogens NIAID, NIH, Hamilton, MT 59840, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 487 EP - 498 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 10 IS - 2 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Macrophages KW - Granulocyte-macrophage colony-stimulating factor KW - RANTES KW - Pathogens KW - Infection KW - Tumor necrosis factor-a KW - Interleukin 10 KW - b-Interferon KW - Nitric-oxide synthase KW - Phagocytes KW - Burkholderia mallei KW - Nitric oxide KW - Multiplicity of infection KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20354942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=iNOS+activity+is+critical+for+the+clearance+of+Burkholderia+mallei+from+infected+RAW+264.7+murine+macrophages&rft.au=Brett%2C+Paul+J%3BBurtnick%2C+Mary+N%3BSu%2C+Hua%3BNair%2C+Vinod%3BGherardini%2C+Frank+C&rft.aulast=Brett&rft.aufirst=Paul&rft.date=2008-02-01&rft.volume=10&rft.issue=2&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2007.01063.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Interleukin 6; Granulocyte-macrophage colony-stimulating factor; RANTES; Pathogens; Tumor necrosis factor-a; Infection; Interleukin 10; Nitric-oxide synthase; b-Interferon; Phagocytes; Nitric oxide; Multiplicity of infection; Burkholderia mallei DO - http://dx.doi.org/10.1111/j.1462-5822.2007.01063.x ER - TY - JOUR T1 - Genetic Characterization of Feline Leukemia Virus from Florida Panthers AN - 20334818; 9015086 AB - The emergent strain of FeLV, a novel subgroup A, was probably transmitted to panthers by a domestic cat. From 2002 through 2005, an outbreak of feline leukemia virus (FeLV) occurred in Florida panthers (Puma concolor coryi). Clinical signs included lymphadenopathy, anemia, septicemia, and weight loss; 5 panthers died. Not associated with FeLV outcome were the genetic heritage of the panthers (pure Florida vs. Texas/Florida crosses) and co-infection with feline immunodeficiency virus. Genetic analysis of panther FeLV, designated FeLV-Pco, determined that the outbreak likely came from 1 cross-species transmission from a domestic cat. The FeLV-Pco virus was closely related to the domestic cat exogenous FeLV-A subgroup in lacking recombinant segments derived from endogenous FeLV. FeLV-Pco sequences were most similar to the well-characterized FeLV-945 strain, which is highly virulent and strongly pathogenic in domestic cats because of unique long terminal repeat and envelope sequences. These unique features may also account for the severity of the outbreak after cross-species transmission to the panther. JF - Emerging Infectious Diseases AU - Brown, Meredith A AU - Cunningham, Mark W AU - Roca, Alfred L AU - Troyer, Jennifer L AU - Johnson, Warren E AU - O'Brien, Stephen J AD - * National Cancer Institute, Frederick, Maryland, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 252 EP - 259 PB - U.S. National Center for Infectious Diseases, 1600 Clifton Rd VL - 14 IS - 2 SN - 1080-6040, 1080-6040 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Communicable diseases KW - emerging KW - leukemia virus KW - feline KW - molecular biology KW - immunodeficiency virus KW - research KW - Lymphadenopathy KW - Envelopes KW - Septicemia KW - Long terminal repeat KW - Feline immunodeficiency virus KW - Genetic analysis KW - Anemia KW - Feline leukemia virus KW - Feline leukemia KW - Disease transmission KW - J 02410:Animal Diseases KW - G 07720:Immunogenetics KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20334818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Genetic+Characterization+of+Feline+Leukemia+Virus+from+Florida+Panthers&rft.au=Brown%2C+Meredith+A%3BCunningham%2C+Mark+W%3BRoca%2C+Alfred+L%3BTroyer%2C+Jennifer+L%3BJohnson%2C+Warren+E%3BO%27Brien%2C+Stephen+J&rft.aulast=Brown&rft.aufirst=Meredith&rft.date=2008-02-01&rft.volume=14&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/10.3201%2Feid1402.070981 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Lymphadenopathy; Envelopes; Septicemia; Long terminal repeat; Genetic analysis; Anemia; Feline leukemia; Disease transmission; Feline immunodeficiency virus; Feline leukemia virus DO - http://dx.doi.org/10.3201/eid1402.070981 ER - TY - JOUR T1 - Microarray-based expression profiling and informatics AN - 20266026; 8853256 AB - Microarray-based expression profiling is a powerful technology for studying biological mechanisms and for developing clinically valuable predictive classifiers. The high-dimensional read-out for each sample assayed makes it possible to do new kinds of studies but also increases the risks of misleading conclusions. We review here the current state-of-the-art for design and analysis of microarray-based investigations. JF - Current Opinion in Biotechnology AU - Simon, Richard AD - National Cancer Institute, 9000 Rockville Pike, MSC 7434, Bethesda, MD 20892, United States, rsimon@nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 26 EP - 29 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 1 SN - 0958-1669, 0958-1669 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20266026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Microarray-based+expression+profiling+and+informatics&rft.au=Simon%2C+Richard&rft.aulast=Simon&rft.aufirst=Richard&rft.date=2008-02-01&rft.volume=19&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2007.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reviews DO - http://dx.doi.org/10.1016/j.copbio.2007.10.008 ER - TY - JOUR T1 - Experimental validation for quantitative protein network models AN - 20262387; 8853259 AB - Cellular responses are the consequence of complex reactions of protein networks. The complexity should ultimately be described by a set of formulas in a quantitative fashion, in which each formula defines the reactions in response to given types of input. However, testing these formulas has not been a simple task because of the lack of appropriate means for experimental validation. 'Reverse-phase' lysate microarrays have been proved to be powerful for such requirements and thus can be a good resource for providing an experimental reference point for the theoretical biology of protein networks. JF - Current Opinion in Biotechnology AU - Nishizuka, Satoshi Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 41 EP - 49 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 1 SN - 0958-1669, 0958-1669 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20262387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Experimental+validation+for+quantitative+protein+network+models&rft.au=Nishizuka%2C+Satoshi&rft.aulast=Nishizuka&rft.aufirst=Satoshi&rft.date=2008-02-01&rft.volume=19&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2007.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reviews DO - http://dx.doi.org/10.1016/j.copbio.2007.11.007 ER - TY - JOUR T1 - Role of Probiotics Stakeholders in Future Research and Policy on Probiotics Use in the United States AN - 20092924; 8372878 JF - Clinical Infectious Diseases AU - Klein, M AU - Dwyer, J AD - Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd., Msc 7517, Bethesda, MD 20892, USA, DwyerJ1@od.nih.gov Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - S144 EP - S151 VL - 46 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - probiotics KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20092924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Role+of+Probiotics+Stakeholders+in+Future+Research+and+Policy+on+Probiotics+Use+in+the+United+States&rft.au=Klein%2C+M%3BDwyer%2C+J&rft.aulast=Klein&rft.aufirst=M&rft.date=2008-02-01&rft.volume=46&rft.issue=&rft.spage=S144&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - probiotics ER - TY - JOUR T1 - Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture AN - 20071767; 10252873 AB - Background The removal of human regulatory T (Treg) cells from a cellular product prior to the induction of a T-cell response has the potential to boost the total yield of antigen (Ag)-specific CD4+ and CD8+ T cells. Methods We examined the effect of this manipulation on the generation of human anti-cytomegalovirus (CMV) T-cell responses. Furthermore, we examined the clonotypic composition of Ag-specific CD4+FOXP3+ and CD4+FOXP3- T cells. Results We found that the immunomagnetic depletion of CD25+ cells had an unpredictable effect on outcome, with total yields of CMV-specific T cells either increasing or decreasing after the removal of these cells. The depletion of CD25+ cells both removed a proportion of Ag-specific T cells and failed to eliminate a substantial population of Treg cells. Furthermore, using a novel T-cell receptor clonotyping technique, we found that Ag recognition induces the expression of FOXP3 in a proportion of specific T cells; these FOXP3-expressing Ag-specific CD4+ and CD8+ T cells were no longer capable of producing inflammatory cytokines. Discussion The depletion of CD25+ cells from the starting population has a variable effect on the total yield of Ag-specific T cells, a proportion of which invariably acquire FOXP3 expression and lose effector function. JF - Cytotherapy AU - Melenhorst, Jj AU - Scheinberg, P AU - Lu, J AU - Sosa, E AU - Zhao, L AU - Hensel, Nf AU - Savani, Bn AU - Douek, Dc AU - Price, Da AU - Barrett, Aj AD - Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 152 EP - 164 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 10 IS - 2 SN - 1465-3249, 1465-3249 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Human cytomegalovirus KW - CD4 antigen KW - Foxp3 protein KW - double prime T-cell receptor KW - Lymphocytes T KW - Cytokines KW - Cell culture KW - CD8 antigen KW - CD25 antigen KW - Inflammation KW - F 06910:Microorganisms & Parasites KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20071767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytotherapy&rft.atitle=Regulatory+T-cell+depletion+does+not+prevent+emergence+of+new+CD25%2B+FOXP3%2B+lymphocytes+after+antigen+stimulation+in+culture&rft.au=Melenhorst%2C+Jj%3BScheinberg%2C+P%3BLu%2C+J%3BSosa%2C+E%3BZhao%2C+L%3BHensel%2C+Nf%3BSavani%2C+Bn%3BDouek%2C+Dc%3BPrice%2C+Da%3BBarrett%2C+Aj&rft.aulast=Melenhorst&rft.aufirst=Jj&rft.date=2008-02-01&rft.volume=10&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Cytotherapy&rft.issn=14653249&rft_id=info:doi/10.1080%2F14653240701853536 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Foxp3 protein; double prime T-cell receptor; Lymphocytes T; Cytokines; Cell culture; CD8 antigen; CD25 antigen; Inflammation; Human cytomegalovirus DO - http://dx.doi.org/10.1080/14653240701853536 ER - TY - JOUR T1 - Pharmacokinetics of Antiretroviral Regimens Containing Tenofovir Disoproxil Fumarate and Atazanavir-Ritonavir in Adolescents and Young Adults with Human Immunodeficiency Virus Infection AN - 20034846; 8032642 AB - The primary objective of this study was to measure atazanavir-ritonavir and tenofovir pharmacokinetics when the drugs were used in combination in young adults with human immunodeficiency virus (HIV). HIV-infected subjects greater than or equal to 18 to <25 years old receiving ( greater than or equal to 28 days) 300/100 mg atazanavir-ritonavir plus 300 mg tenofovir disoproxil fumarate (TDF) plus one or more other nucleoside analogs underwent intensive 24-h pharmacokinetic studies following a light meal. Peripheral blood mononuclear cells were obtained at 1, 4, and 24 h postdose for quantification of intracellular tenofovir diphosphate (TFV-DP) concentrations. Twenty-two subjects were eligible for analyses. The geometric mean (95% confidence interval [CI]) atazanavir area under the concentration-time curve from 0 to 24 h (AUC sub(0-24)), maximum concentration of drug in serum (C sub(max)), concentration at 24 h postdose (C sub(24)), and total apparent oral clearance (CL/F) values were 35,971 ng.hr/ml (30,853 to 41,898), 3,504 ng/ml (2,978 to 4,105), 578 ng/ml (474 to 704), and 8.3 liter/hr (7.2 to 9.7), respectively. The geometric mean (95% CI) tenofovir AUC sub(0-24), C sub(max), C sub(24), and CL/F values were 2,762 ng.hr/ml (2,392 to 3,041), 254 ng/ml (221 to 292), 60 ng/ml (52 to 68), and 49.2 liter/hr (43.8 to 55.3), respectively. Body weight was significantly predictive of CL/F for all three drugs. For every 10-kg increase in weight, there was a 10%, 14.8%, and 6.8% increase in the atazanavir, ritonavir, and tenofovir CL/F, respectively (P less than or equal to 0.01). Renal function was predictive of tenofovir CL/F. For every 10 ml/min increase in creatinine clearance, there was a 4.6% increase in tenofovir CL/F (P < 0.0001). The geometric mean (95% CI) TFV-DP concentrations at 1, 4, and 24 h postdose were 96.4 (71.5 to 130), 93.3 (68 to 130), and 92.7 (70 to 123) fmol/million cells. There was an association between renal function, tenofovir AUC, and tenofovir C sub(max) and intracellular TFV-DP concentrations, although none of these associations reached statistical significance. In these HIV-infected young adults treated with atazanavir-ritonavir plus TDF, the atazanavir AUC was similar to those of older adults treated with the combination. Based on data for healthy volunteers, a higher tenofovir AUC may have been expected, but was not seen in these subjects. This might be due to faster tenofovir CL/F because of higher creatinine clearance in this age group. Additional studies of the exposure-response relationships of this regimen in children, adolescents, and adults would advance our knowledge of its pharmacodynamic properties. JF - Antimicrobial Agents & Chemotherapy AU - Kiser, Jennifer J AU - Fletcher, Courtney V AU - Flynn, Patricia M AU - Cunningham, Coleen K AU - Wilson, Craig M AU - Kapogiannis, Bill G AU - Major-Wilson, Hanna AU - Viani, Rolando M AU - Liu, Nancy X AU - Muenz, Larry R AU - Harris, DRobert AU - Havens, Peter L AD - University of Colorado at Denver and Health Sciences Center, Denver, CO. St. Jude Children's Research Hospital, Memphis, TN. Duke University Medical Center, Durham, NC. University of Alabama at Birmingham, Birmingham, AL. National Institute of Child Health and Human Development, Bethesda, MD. University of Miami Miller School of Medicine, Miami, FL. University of California San Diego, La Jolla, CA. Westat, Rockville, MD. Medical College of Wisconsin, Milwaukee, WI Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 631 EP - 637 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Age KW - Statistics KW - Data processing KW - Adolescence KW - tenofovir KW - Infection KW - Children KW - Pharmacokinetics KW - Light effects KW - nucleoside analogs KW - Peripheral blood mononuclear cells KW - Creatinine KW - Body weight KW - Renal function KW - Antiviral agents KW - Human immunodeficiency virus KW - Ritonavir KW - Dose-response effects KW - Drugs KW - Pharmacodynamics KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20034846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Pharmacokinetics+of+Antiretroviral+Regimens+Containing+Tenofovir+Disoproxil+Fumarate+and+Atazanavir-Ritonavir+in+Adolescents+and+Young+Adults+with+Human+Immunodeficiency+Virus+Infection&rft.au=Kiser%2C+Jennifer+J%3BFletcher%2C+Courtney+V%3BFlynn%2C+Patricia+M%3BCunningham%2C+Coleen+K%3BWilson%2C+Craig+M%3BKapogiannis%2C+Bill+G%3BMajor-Wilson%2C+Hanna%3BViani%2C+Rolando+M%3BLiu%2C+Nancy+X%3BMuenz%2C+Larry+R%3BHarris%2C+DRobert%3BHavens%2C+Peter+L&rft.aulast=Kiser&rft.aufirst=Jennifer&rft.date=2008-02-01&rft.volume=52&rft.issue=2&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Statistics; Adolescence; tenofovir; Children; Infection; Pharmacokinetics; Light effects; nucleoside analogs; Peripheral blood mononuclear cells; Creatinine; Antiviral agents; Renal function; Body weight; Ritonavir; Dose-response effects; Drugs; Pharmacodynamics; Human immunodeficiency virus ER - TY - JOUR T1 - Zygomycetes Hyphae Trigger an Early, Robust Proinflammatory Response in Human Polymorphonuclear Neutrophils through Toll-Like Receptor 2 Induction but Display Relative Resistance to Oxidative Damage AN - 20015060; 8032654 AB - Human polymorphonuclear neutrophils (HPMNs) displayed attenuated hyphal damage associated with impaired O sub(2) super(-) release following exposure to Rhizopus oryzae versus that with Aspergillus fumigatus. Exposure of HPMNs to R. oryzae hyphae resulted in upregulation in Toll-like receptor 2 mRNA and a robust proinflammatory gene expression with rapid (1-h) induction of NF- Kappa B pathway-related genes. JF - Antimicrobial Agents & Chemotherapy AU - Chamilos, G AU - Lewis, R E AU - Lamaris, G AU - Walsh, T J AU - Kontoyiannis, D P AD - Departments of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas. University of Houston College of Pharmacy, Houston, Texas. Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 722 EP - 724 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Gene expression KW - Rhizopus oryzae KW - Aspergillus fumigatus KW - Leukocytes (polymorphonuclear) KW - Hyphae KW - Toll-like receptors KW - Zygomycetes KW - Inflammation KW - NF- Kappa B protein KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20015060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Zygomycetes+Hyphae+Trigger+an+Early%2C+Robust+Proinflammatory+Response+in+Human+Polymorphonuclear+Neutrophils+through+Toll-Like+Receptor+2+Induction+but+Display+Relative+Resistance+to+Oxidative+Damage&rft.au=Chamilos%2C+G%3BLewis%2C+R+E%3BLamaris%2C+G%3BWalsh%2C+T+J%3BKontoyiannis%2C+D+P&rft.aulast=Chamilos&rft.aufirst=G&rft.date=2008-02-01&rft.volume=52&rft.issue=2&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Leukocytes (polymorphonuclear); Hyphae; Toll-like receptors; NF- Kappa B protein; Inflammation; Rhizopus oryzae; Aspergillus fumigatus; Zygomycetes ER - TY - JOUR T1 - The Microbicide Tenofovir Does Not Inhibit Nucleic Acid Amplification Tests for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Urine Samples AN - 19997875; 8039171 AB - The potential inhibitory effects of tenofovir and a placebo were examined using the Becton Dickinson ProbeTec, Gen-Probe Aptima Combo 2, and Roche Amplicor tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae. Concentrations of 5% to 0% of tenofovir and the placebo were added to dilutions of C. trachomatis and N. gonorrhoeae. No appreciable inhibition was observed. JF - Journal of Clinical Microbiology AU - Wood, Billie Jo AU - Rizzo-Price, Patricia AU - Holden, Jeff AU - Hardick, Andrew AU - Quinn, Thomas C AU - Gaydos, Charlotte A AD - The Johns Hopkins University School of Medicine, Division of Infectious Diseases, Baltimore, Maryland. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 763 EP - 765 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 46 IS - 2 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - nucleic acids KW - Urine KW - Chlamydia trachomatis KW - tenofovir KW - Neisseria gonorrhoeae KW - microbicides KW - A 01340:Antibiotics & Antimicrobials KW - N 14845:Miscellaneous KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19997875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=The+Microbicide+Tenofovir+Does+Not+Inhibit+Nucleic+Acid+Amplification+Tests+for+Detection+of+Chlamydia+trachomatis+and+Neisseria+gonorrhoeae+in+Urine+Samples&rft.au=Wood%2C+Billie+Jo%3BRizzo-Price%2C+Patricia%3BHolden%2C+Jeff%3BHardick%2C+Andrew%3BQuinn%2C+Thomas+C%3BGaydos%2C+Charlotte+A&rft.aulast=Wood&rft.aufirst=Billie&rft.date=2008-02-01&rft.volume=46&rft.issue=2&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - nucleic acids; Urine; tenofovir; microbicides; Chlamydia trachomatis; Neisseria gonorrhoeae ER - TY - JOUR T1 - Airway Smooth Muscle in Bronchial Tone, Inflammation, and Remodeling: Basic Knowledge to Clinical Relevance AN - 199607354; 18006883 AB - Airway smooth muscle (ASM) plays a pivotal role in modulating bronchomotor tone but also orchestrates and perpetuates airway inflammation and remodeling. Despite substantial research, there remain important unanswered questions. In 2006, the National Heart, Lung, and Blood Institute sponsored a workshop to define new directions in ASM biology. Important questions concerning the key functions of ASM include the following: Does developmental dysregulation of ASM function promote airway disease, what key signaling pathways in ASM evoke airway hyperresponsiveness in vivo, do alterations in ASM mass affect excitation-contraction coupling, and can ASM modulate airway inflammation and remodeling in a physiologically relevant manner? This workshop identified critical issues in ASM biology to delineate areas for scientific investigation in the identification of new therapeutic and diagnostic approaches in asthma, chronic obstructive pulmonary disease, and cystic fibrosis. JF - American Journal of Respiratory and Critical Care Medicine AU - Panettieri, Reynold A, Jr AU - Kotlikoff, Michael I AU - Gerthoffer, William T AU - Hershenson, Marc B AU - Woodruff, Prescott G AU - Hall, Ian P AU - Banks-Schlegel, Susan Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 248 EP - 52 CY - New York PB - American Thoracic Society VL - 177 IS - 3 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Actins KW - United States KW - National Heart, Lung, & Blood Institute (U.S.) KW - Actins -- physiology KW - Inflammation -- physiopathology KW - Humans KW - Bronchoconstriction -- immunology KW - Muscle, Smooth -- physiology KW - Bronchoconstriction -- physiology KW - Muscle, Smooth -- immunology KW - Respiratory System -- growth & development KW - Respiratory System -- immunology KW - Respiratory System -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199607354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Airway+Smooth+Muscle+in+Bronchial+Tone%2C+Inflammation%2C+and+Remodeling%3A+Basic+Knowledge+to+Clinical+Relevance&rft.au=Panettieri%2C+Reynold+A%2C+Jr%3BKotlikoff%2C+Michael+I%3BGerthoffer%2C+William+T%3BHershenson%2C+Marc+B%3BWoodruff%2C+Prescott+G%3BHall%2C+Ian+P%3BBanks-Schlegel%2C+Susan&rft.aulast=Panettieri&rft.aufirst=Reynold&rft.date=2008-02-01&rft.volume=177&rft.issue=3&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Feb 1, 2008 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Pathogenic Diversity among Chlamydia trachomatis Ocular Strains in Nonhuman Primates Is Affected by Subtle Genomic Variations AN - 19899616; 8452009 AB - Chlamydia trachomatis is the etiological agent of trachoma, the leading cause of preventable blindness. Trachoma presents distinct clinical syndromes ranging from mild and self-limiting to severe inflammatory disease. The underlying host and pathogen factors responsible for these diverse clinical outcomes are unclear. To assess the role played by pathogen variation in disease outcome, we analyzed the genomes of 4 trachoma strains representative of the 3 major trachoma serotypes, using microarray-based comparative genome sequencing. Outside of ompA, trachoma strains differed primarily in a very small subset of genes (n - 22). These subtle genetic variations were manifested in profound differences in virulence as measured by in vitro growth rate, burst size, plaque morphology, and interferon-Y sensitivity but most importantly in virulence as shown by ocular infection of nonhuman primates. Our findings are the first to identify genes that correlate with differences in pathogenicity among trachoma strains. JF - Journal of Infectious Diseases AU - Kari, L AU - Whitmire, WM AU - Carlson, J H AU - Crane, D D AU - Reveneau, N AU - Nelson, DE AU - Mabey, DCW AU - Bailey, R L AU - Holland, MJ AU - McClarty, G AU - Caldwell, H D AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 S. 4th St., Hamilton, MT 59840, USA, hcaldwell@niald.nih.gov Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 449 EP - 456 VL - 197 IS - 3 SN - 0022-1899, 0022-1899 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Growth rate KW - Genomes KW - Serotypes KW - Burst size KW - Chlamydia trachomatis KW - Blindness KW - Pathogens KW - Infection KW - Primates KW - Trachoma KW - Virulence KW - Pathogenicity KW - Inflammatory diseases KW - Plaques KW - genomics KW - J 02400:Human Diseases KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19899616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Pathogenic+Diversity+among+Chlamydia+trachomatis+Ocular+Strains+in+Nonhuman+Primates+Is+Affected+by+Subtle+Genomic+Variations&rft.au=Kari%2C+L%3BWhitmire%2C+WM%3BCarlson%2C+J+H%3BCrane%2C+D+D%3BReveneau%2C+N%3BNelson%2C+DE%3BMabey%2C+DCW%3BBailey%2C+R+L%3BHolland%2C+MJ%3BMcClarty%2C+G%3BCaldwell%2C+H+D&rft.aulast=Kari&rft.aufirst=L&rft.date=2008-02-01&rft.volume=197&rft.issue=3&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F525285 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Growth rate; Serotypes; Burst size; Pathogens; Blindness; Infection; Trachoma; Virulence; Inflammatory diseases; Pathogenicity; Plaques; genomics; Chlamydia trachomatis; Primates DO - http://dx.doi.org/10.1086/525285 ER - TY - JOUR T1 - Use of a Recombinant Fluorescent Substrate with Cleavage Sites for All Botulinum Neurotoxins in High-Throughput Screening of Natural Product Extracts for Inhibitors of Serotypes A, B, and E AN - 19887441; 8032720 AB - The seven serotypes of botulinum neurotoxin (BoNTs) are zinc metalloproteases that cleave and inactivate proteins critical for neurotransmission. The synaptosomal protein of 25 kDa (SNAP-25) is cleaved by BoNTs A, C, and E, while vesicle-associated membrane protein (VAMP) is the substrate for BoNTs B, D, F, and G. BoNTs not only are medically useful drugs but also are potential bioterrorist and biowarfare threat agents. Because BoNT protease activity is required for toxicity, inhibitors of that activity might be effective for antibotulinum therapy. To expedite inhibitor discovery, we constructed a hybrid gene encoding (from the N terminus to the C terminus, with respect to the expressed product) green fluorescent protein, then a SNAP-25 fragment encompassing residues Met-127 to Gly-206, and then VAMP residues Met-1 to Lys-94. Cysteine was added as the C terminus. The expressed product, which contained the protease cleavage sites for all seven botulinum serotypes, was purified and coupled covalently through the C-terminal sulfhydryl group to maleimide-activated 96-well plates. The substrate was readily cleaved by BoNTs A, B, D, E, and F. Using this assay and an automated 96-well pipettor, we screened 528 natural product extracts for inhibitors of BoNT A, B, and E protease activities. Serotype-specific inhibition was found in 30 extracts, while 5 others inhibited two serotypes. JF - Applied and Environmental Microbiology AU - Hines, Harry B AU - Kim, Alexander D AU - Stafford, Robert G AU - Badie, Shirin S AU - Brueggeman, Ernst E AU - Newman, David J AU - Schmidt, James J AD - Department of Cell Biology and Biochemistry, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702-5011. Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21701-1201 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 653 EP - 659 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 3 SN - 0099-2240, 0099-2240 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - Serotypes KW - Green fluorescent protein KW - natural products KW - Membrane proteins KW - Sulfhydryl groups KW - Toxicity KW - Metalloproteinase KW - Neurotransmission KW - Cysteine KW - SNAP-25 protein KW - Hybrids KW - Zinc KW - high-throughput screening KW - Cadmium KW - Proteinase KW - Botulinum toxin KW - Drugs KW - W 30925:Genetic Engineering KW - N3 11008:Neurochemistry KW - A 01310:Products of Microorganisms KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19887441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Use+of+a+Recombinant+Fluorescent+Substrate+with+Cleavage+Sites+for+All+Botulinum+Neurotoxins+in+High-Throughput+Screening+of+Natural+Product+Extracts+for+Inhibitors+of+Serotypes+A%2C+B%2C+and+E&rft.au=Hines%2C+Harry+B%3BKim%2C+Alexander+D%3BStafford%2C+Robert+G%3BBadie%2C+Shirin+S%3BBrueggeman%2C+Ernst+E%3BNewman%2C+David+J%3BSchmidt%2C+James+J&rft.aulast=Hines&rft.aufirst=Harry&rft.date=2008-02-01&rft.volume=74&rft.issue=3&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Serotypes; Green fluorescent protein; natural products; Toxicity; Sulfhydryl groups; Membrane proteins; Metalloproteinase; Neurotransmission; Cysteine; Hybrids; SNAP-25 protein; Zinc; Proteinase; Cadmium; high-throughput screening; Botulinum toxin; Drugs ER - TY - JOUR T1 - The Salmonella-containing vacuole-Moving with the times AN - 19743403; 8548845 AB - Salmonella pathogenesis is dependent on its ability to invade and replicate within host cells. Following invasion the bacteria remain within a modified phagosome known as the Salmonella-containing vacuole (SCV), within which they will survive and replicate. Invasion and SCV biogenesis are dependent on two Type III secretion systems, T3SS1 and T3SS2, which are used to translocate distinct cohorts of bacterial effector proteins into the host cell. Elucidating the roles of individual effector proteins in SCV biogenesis has proven difficult but several distinct themes are now emerging and it is apparent that SCV biogenesis is an extremely dynamic process involving; extensive membrane remodeling, interactions with the endolysosomal pathway, actin rearrangements and microtubule-based movement and tubule extension. JF - Current Opinion in Microbiology AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, 903 South 4th Street, Hamilton, MT 59840, USA, omortimer@niaid.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 38 EP - 45 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 11 IS - 1 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts B: Bacteriology KW - Secretion KW - Reviews KW - Vacuoles KW - Phagosomes KW - Actin KW - Salmonella KW - Tubules KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19743403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=The+Salmonella-containing+vacuole-Moving+with+the+times&rft.au=Steele-Mortimer%2C+Olivia&rft.aulast=Steele-Mortimer&rft.aufirst=Olivia&rft.date=2008-02-01&rft.volume=11&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2008.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Reviews; Secretion; Phagosomes; Vacuoles; Actin; Tubules; Salmonella DO - http://dx.doi.org/10.1016/j.mib.2008.01.002 ER - TY - JOUR T1 - The use of inversion mode and 3D manual segmentation in volume measurement of fetal fluid-filled structures: comparison with Virtual Organ Computer-aided AnaLysis (VOCALTM) AN - 19718277; 8635531 AB - Objective Volume measurements by three-dimensional (3D) ultrasonography are considered more accurate than those performed by two-dimensional (2D) ultrasonography. The purpose of this study was to compare the agreement of three techniques, as well as the inter- and intraobserver agreements for volume measurements of fetal fluid-filled structures. Methods Fifty 3D volume datasets of fetal stomachs and bladders were explored. Volume measurements were performed independently by two observers using: (1) Virtual Organ Computer-aided AnaLysis (VOCALTM); (2) inversion mode; and (3) manual segmentation. Reliability was evaluated using intraclass correlation coefficient (ICC), and Bland-Altman plots were generated to examine bias and agreement. The time required to complete the measurements was compared using Student's t-test or the Wilcoxon Signed Rank Test, and P-values < 0.025 or < 0.05 were considered statistically significant. Results All volume datasets could be measured using the three techniques. A high degree of reliability was observed between: (1) VOCAL and inversion mode (ICC, 0.995; 95% CI, 0.992-0.997); (2) VOCAL and manual segmentation (ICC, 0.997; 95% CI, 0.995-0.998); and (3) inversion mode and manual segmentation (ICC, 0.995; 95% CI, 0.992-0.997). There was good agreement between VOCAL and inversion mode (mean, - 2.4%; 95% limits of agreement, - 20.1 to 15.3%), VOCAL and manual segmentation (mean, - 8.3%; 95% limits of agreement, - 28.8 to 12.2%) as well as between inversion mode and manual segmentation (mean, 5.9%, 95% limits of agreement: - 14.3 to 26%). Manual segmentation and inversion mode measurements were obtained significantly faster than those by VOCAL. Conclusions Volume measurements of fetal fluid-filled structures of relatively regular shape with inversion mode and manual segmentation are feasible. Both techniques have good agreement with VOCAL and are significantly faster than VOCAL. Inversion mode is a reliable method for volume calculations of fluid-filled organs, whereas manual segmentation can be used when volume measurements by VOCAL or inversion mode are technically difficult to obtain, such as solid structures with poorly defined borders as the volume dataset is rotated, like the uterine cervix. JF - Ultrasound in Obstetrics and Gynecology AU - Kusanovic, J P AU - Nien, J K AU - Goncalves, L F AU - Espinoza, J AU - Lee, W AU - Balasubramaniam, M AU - Soto, E AU - Erez, O AU - Romero, R AD - Perinatology Research Branch, NICHD, NIH, DHHS, Bethesda, MD and Detroit, MI, USA, prbchiefstaff@med.wayne.edu Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 177 EP - 186 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 31 IS - 2 SN - 0960-7692, 0960-7692 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Uterus KW - Gynecology KW - Urinary bladder KW - Statistical analysis KW - Ultrasonography KW - Fetuses KW - Inversion KW - Segmentation KW - Cervix KW - Ultrasound KW - Obstetrics KW - Stomach KW - G 07880:Human Genetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19718277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=The+use+of+inversion+mode+and+3D+manual+segmentation+in+volume+measurement+of+fetal+fluid-filled+structures%3A+comparison+with+Virtual+Organ+Computer-aided+AnaLysis+%28VOCALTM%29&rft.au=Kusanovic%2C+J+P%3BNien%2C+J+K%3BGoncalves%2C+L+F%3BEspinoza%2C+J%3BLee%2C+W%3BBalasubramaniam%2C+M%3BSoto%2C+E%3BErez%2C+O%3BRomero%2C+R&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2008-02-01&rft.volume=31&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.5242 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Uterus; Gynecology; Urinary bladder; Inversion; Statistical analysis; Segmentation; Cervix; Obstetrics; Ultrasound; Ultrasonography; Stomach; Fetuses DO - http://dx.doi.org/10.1002/uog.5242 ER - TY - JOUR T1 - Alternative Mechanisms by Which Mediator Subunit MED1/TRAP220 Regulates Peroxisome Proliferator-Activated Receptor gamma -Stimulated Adipogenesis and Target Gene Expression AN - 19705809; 8040679 AB - Mediator is a general coactivator complex connecting transcription activators and RNA polymerase II. Recent work has shown that the nuclear receptor-interacting MED1/TRAP220 subunit of Mediator is required for peroxisome proliferator-activated receptor gamma (PPAR gamma )-stimulated adipogenesis of mouse embryonic fibroblasts (MEFs). However, the molecular mechanisms remain undefined. Here, we show an intracellular PPAR gamma -Mediator interaction that requires the two LXXLL nuclear receptor recognition motifs on MED1/TRAP220 and, furthermore, we show that the intact LXXLL motifs are essential for optimal PPAR gamma function in a reconstituted cell-free transcription system. Surprisingly, a conserved N-terminal region of MED1/TRAP220 that lacks the LXXLL motifs but gets incorporated into Mediator fully supports PPAR gamma -stimulated adipogenesis. Moreover, in undifferentiated MEFs, MED1/TRAP220 is dispensable both for PPAR gamma -mediated target gene activation and for recruitment of Mediator to a PPAR response element on the aP2 target gene promoter. However, PPAR gamma shows significantly reduced transcriptional activity in cells deficient for a subunit (MED24/TRAP100) important for the integrity of the Mediator complex, indicating a general Mediator requirement for PPAR gamma function. These results indicate that there is a conditional requirement for MED1/TRAP220 and that a direct interaction between PPAR gamma and Mediator through MED1/TRAP220 is not essential either for PPAR gamma -stimulated adipogenesis or for PPAR gamma target gene expression in cultured fibroblasts. As Mediator is apparently essential for PPAR gamma transcriptional activity, our data indicate the presence of alternative mechanisms for Mediator recruitment, possibly through intermediate cofactors or other cofactors that are functionally redundant with MED1/TRAP220. JF - Molecular and Cellular Biology AU - Ge, Kai AU - Cho, Young-Wook AU - Guo, Hong AU - Hong, Teresa B AU - Guermah, Mohamed AU - Ito, Mitsuhiro AU - Yu, Hong AU - Kalkum, Markus AU - Roeder, Robert G AD - Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892. Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, New York 10021. Beckman Research Institute of the City of Hope, Immunology Division, Duarte, California 91010 Y1 - 2008/02/01/ PY - 2008 DA - 2008 Feb 01 SP - 1081 EP - 1091 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 28 IS - 3 SN - 0270-7306, 0270-7306 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Molecular modelling KW - Data processing KW - Peroxisome proliferator-activated receptors KW - Nuclear receptors KW - Regulatory sequences KW - Transcription KW - Gene expression KW - Promoters KW - DNA-directed RNA polymerase KW - Cofactors KW - Transcription factors KW - Embryo fibroblasts KW - adipogenesis KW - Transcription activation KW - W 30940:Products KW - G 07870:Mammals KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19705809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Alternative+Mechanisms+by+Which+Mediator+Subunit+MED1%2FTRAP220+Regulates+Peroxisome+Proliferator-Activated+Receptor+gamma+-Stimulated+Adipogenesis+and+Target+Gene+Expression&rft.au=Ge%2C+Kai%3BCho%2C+Young-Wook%3BGuo%2C+Hong%3BHong%2C+Teresa+B%3BGuermah%2C+Mohamed%3BIto%2C+Mitsuhiro%3BYu%2C+Hong%3BKalkum%2C+Markus%3BRoeder%2C+Robert+G&rft.aulast=Ge&rft.aufirst=Kai&rft.date=2008-02-01&rft.volume=28&rft.issue=3&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Data processing; Peroxisome proliferator-activated receptors; Regulatory sequences; Nuclear receptors; Transcription; Gene expression; Promoters; DNA-directed RNA polymerase; Cofactors; Transcription factors; Embryo fibroblasts; adipogenesis; Transcription activation ER - TY - JOUR T1 - Cancer incidence rates among South Asians in four geographic regions: India, Singapore, UK and US AN - 19612237; 8510739 AB - Background Data are limited regarding cancer incidence among Indians residing in different geographic regions around the world. Examining such rates may provide us with insights into future aetiological research possibilities as well as screening and prevention.Methods Incidence rates for all cancers combined and 19 specific cancers were obtained for India from Globocan 2002, for Indians in Singapore from Cancer Incidence in Five Continents (VIII), and from national data sources for South Asians (SA) in the United Kingdom (UK) and for Asian Indians/Pakistanis (AIP) and whites in the United States (US).Results We observed the lowest total cancer incidence rates in India (111 and 116 per 100 000 among males and females, respectively, age-standardized to the 1960 world population) and the highest among US whites (362 and 296). Cancer incidence rates among Indians residing outside of India were: intermediate Singapore (102 and 132), UK (173 and 179) and US ranges 152-176 and 142-164. A similar pattern was observed for cancers of the colorectum, prostate, thyroid, pancreas, lung, breast and non-Hodgkin lymphoma. In contrast, rates for cancers of the oral cavity, oesophagus, larynx and cervix uteri were highest in India. Although little geographic variability was apparent for stomach cancer incidence, Indians in Singapore had the highest rates compared with any other region. The UK SA and the US AIP appear with adopt the cancer patterns of their host country.Conclusion Variations in environmental exposures such as tobacco use, diet and infection, as well as better health care access and knowledge may explain some of the observed incidence differences. JF - International Journal of Epidemiology AU - Rastogi, Tanuja AU - Devesa, Susan AU - Mangtani, Punam AU - Mathew, Aleyamma AU - Cooper, Nicola AU - Kao, Roy AU - Sinha, Rashmi AD - 1 Division of Cancer Epidemiology & Genetics (DCEG), National Cancer Institute (NCI), NIH, DHHS, Rockville, MD, USA., sinhar@nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 147 EP - 160 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 37 IS - 1 SN - 0300-5771, 0300-5771 KW - Risk Abstracts KW - non-Hodgkin's lymphoma KW - India KW - world population KW - continents KW - infection KW - Tobacco KW - Diets KW - British Isles KW - Thyroid KW - Cancer KW - USA KW - Health care KW - Lung KW - Singapore KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19612237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Cancer+incidence+rates+among+South+Asians+in+four+geographic+regions%3A+India%2C+Singapore%2C+UK+and+US&rft.au=Rastogi%2C+Tanuja%3BDevesa%2C+Susan%3BMangtani%2C+Punam%3BMathew%2C+Aleyamma%3BCooper%2C+Nicola%3BKao%2C+Roy%3BSinha%2C+Rashmi&rft.aulast=Rastogi&rft.aufirst=Tanuja&rft.date=2008-02-01&rft.volume=37&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/10.1093%2Fije%2Fdym219 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - India; British Isles; Singapore; USA; Cancer; Tobacco; world population; Diets; Health care; infection; Thyroid; continents; Lung; non-Hodgkin's lymphoma DO - http://dx.doi.org/10.1093/ije/dym219 ER - TY - JOUR T1 - Development of craniofacial structures in transgenic mice with constitutively active PTH/PTHrP receptor AN - 19523287; 8091225 AB - Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) regulate calcium homeostasis, and PTHrP further regulates growth and development. A transgenic mouse carrying the constitutively active PTH/PTHrP receptor (HKrk-H223R) under the control of the mouse bone and odontoblast-specific alpha 1(I) collagen promoter (Col1-caPPR) has been developed to demonstrate the complex actions of this mutant receptor in hard tissue formation. We have further characterized Col1-caPPR mice abnormalities in the craniofacial region as a function of development. Col1-caPPR mice exhibited a delay in embryonic bone formation, followed by expansion of a number of craniofacial bones including the maxilla and mandible, delay in tooth eruption and teratosis, and a disrupted temporomandibular joint (TMJ). These findings suggest that the Col1-caPPR mouse is a useful model for characterization of the downstream effects of the constitutively active receptor during development and growth, and as a model for development of treatments of human diseases with similar characteristics. JF - Bone AU - Tsutsui, T W AU - Riminucci, M AU - Holmbeck, K AU - Bianco, P AU - Robey, P G AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Department Health Human Services, Bethesda, MD, USA, ryuryu@tokyo.ndu.ac.jp Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 321 EP - 331 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 42 IS - 2 SN - 8756-3282, 8756-3282 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Teeth KW - Calcium homeostasis KW - Temporomandibular joint KW - Maxilla KW - Animal models KW - Parathyroid hormone-related protein receptors KW - Development KW - Transgenic mice KW - Collagen KW - Mandible KW - Promoters KW - craniofacial growth KW - Parathyroid hormone-related protein KW - Parathyroid hormone KW - Embryos KW - Osteogenesis KW - T 2045:Teeth KW - G 07730:Development & Cell Cycle KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19523287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone&rft.atitle=Development+of+craniofacial+structures+in+transgenic+mice+with+constitutively+active+PTH%2FPTHrP+receptor&rft.au=Tsutsui%2C+T+W%3BRiminucci%2C+M%3BHolmbeck%2C+K%3BBianco%2C+P%3BRobey%2C+P+G&rft.aulast=Tsutsui&rft.aufirst=T&rft.date=2008-02-01&rft.volume=42&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Bone&rft.issn=87563282&rft_id=info:doi/10.1016%2Fj.bone.2007.09.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Teeth; Calcium homeostasis; Temporomandibular joint; Maxilla; Parathyroid hormone-related protein receptors; Animal models; Development; Transgenic mice; Collagen; Mandible; Promoters; craniofacial growth; Parathyroid hormone-related protein; Parathyroid hormone; Embryos; Osteogenesis DO - http://dx.doi.org/10.1016/j.bone.2007.09.057 ER - TY - JOUR T1 - Urinary hCG patterns during the week following implantation AN - 19466249; 8037318 AB - BACKGROUND: Human chorionic gonadotrophin (hCG) is used to monitor pregnancy status. Yet the pattern of hCG excretion in the first week following implantation has not been adequately described.Therefore the aim of this study was to describe the average profile of hCG and its variability during the 7 days following estimated implantation in a population of naturally conceived pregnancies. METHODS: We measured daily hCG concentrations in first-morning urine for 142 clinical pregnancies from women with no known fertility problems. Mixed-effects regression models were used to estimate the hCG trajectory and its variability in relation to pregnancy outcomes. RESULTS: hCG rose 3-fold between the day of detection and the next day (95% CI = 2.7-3.4). The relative rate of rise decreased thereafter, reaching 1.6-fold (95% CI = 1.5-1.8) between days 6 and 7. HCG levels followed a log-quadratic trajectory, and the patterns of rise were unrelated to number of fetuses, risk of spontaneous abortion or sex of the baby. Later implantations (after 10 luteal days) produced slower rates of increase. CONCLUSIONS: Although mean hCG follows a log-quadratic trajectory during the first week of detectability, there is high variability across pregnancies. Later implantation may reflect characteristics of the uterus or conceptus that slow hCG production. JF - Human Reproduction AU - Nepomnaschy, P A AU - Weinberg, C R AU - Wilcox, A J AU - Baird, D D AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO BOX 12233, MD A3-05, Rm 309, 111 TW Alexander Drive, Research Triangle Park, NC, USA. Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 271 EP - 277 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 2 SN - 0268-1161, 0268-1161 KW - Biotechnology and Bioengineering Abstracts KW - Fertility KW - Uterus KW - Urine KW - Abortion KW - Regression analysis KW - Excretion KW - Pituitary (anterior) KW - Fetuses KW - Pregnancy KW - Models KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Urinary+hCG+patterns+during+the+week+following+implantation&rft.au=Nepomnaschy%2C+P+A%3BWeinberg%2C+C+R%3BWilcox%2C+A+J%3BBaird%2C+D+D&rft.aulast=Nepomnaschy&rft.aufirst=P&rft.date=2008-02-01&rft.volume=23&rft.issue=2&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Uterus; Fertility; Urine; Abortion; Regression analysis; Excretion; Pituitary (anterior); Fetuses; Models; Pregnancy ER - TY - JOUR T1 - Pneumocystis Encodes a Functional S-Adenosylmethionine Synthetase Gene AN - 19466057; 8036961 AB - S-Adenosylmethionine (AdoMet) synthetase (EC 2.5.1.6) is the enzyme that catalyzes the synthesis of AdoMet, a molecule important for all cellular organisms. We have cloned and characterized an AdoMet synthetase gene (sam1) from Pneumocystis spp. This gene was transcribed primarily as an similar to 1.3-kb mRNA which encodes a protein containing 381 amino acids in P. carinii or P. murina and 382 amino acids in P. jirovecii. sam1 was also transcribed as part of an apparent polycistronic transcript of similar to 5.6 kb, together with a putative chromatin remodeling protein homologous to Saccharomyces cerevisiae, CHD1. Recombinant Sam1, when expressed in Escherichia coli, showed functional enzyme activity. Immunoprecipitation and confocal immunofluorescence analysis using an antipeptide antibody showed that this enzyme is expressed in P. murina. Thus, Pneumocystis, like other organisms, can synthesize its own AdoMet and may not depend on its host for the supply of this important molecule. JF - Eukaryotic Cell AU - Kutty, Geetha AU - Hernandez-Novoa, Beatriz AU - Czapiga, Meggan AU - Kovacs, Joseph A AD - Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland. Research Technologies Branch, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 258 EP - 267 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 7 IS - 2 SN - 1535-9778, 1535-9778 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Antibodies KW - Amino acids KW - Chromatin remodeling KW - Escherichia coli KW - Pneumocystis KW - Immunoprecipitation KW - Enzymes KW - Transcription KW - Immunofluorescence KW - S-Adenosylmethionine KW - Saccharomyces cerevisiae KW - J 02310:Genetics & Taxonomy KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eukaryotic+Cell&rft.atitle=Pneumocystis+Encodes+a+Functional+S-Adenosylmethionine+Synthetase+Gene&rft.au=Kutty%2C+Geetha%3BHernandez-Novoa%2C+Beatriz%3BCzapiga%2C+Meggan%3BKovacs%2C+Joseph+A&rft.aulast=Kutty&rft.aufirst=Geetha&rft.date=2008-02-01&rft.volume=7&rft.issue=2&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Eukaryotic+Cell&rft.issn=15359778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antibodies; Amino acids; Chromatin remodeling; Immunoprecipitation; Transcription; Enzymes; Immunofluorescence; S-Adenosylmethionine; Pneumocystis; Escherichia coli; Saccharomyces cerevisiae ER - TY - JOUR T1 - Differences in the endometrial transcript profile during the receptive period between women who were refractory to implantation and those who achieved pregnancy AN - 19464751; 8037329 AB - BACKGROUND: Gene expression profiling of normal receptive endometrium has been characterized, but intrinsic defects in endometrial gene expression associated with implantation failure have not been reported. METHODS: Women who had previously participated as recipients in oocyte donation cycles and repeatedly exhibited implantation failure (Group A, study group) or had at least one successful cycle (Group B, control group) and spontaneously fertile women (Group C, normal fertility group) were recruited. All were treated with exogenous estradiol and progesterone to induce an endometrial cycle, and an endometrial biopsy was taken on the seventh day of progesterone administration. RNA from each sample was analysed by cDNA microarrays to identify differentially expressed genes between groups. RESULTS: 63 transcripts were differentially expressed ( greater than or equal to 2-fold) between Groups A and B, of which 16 were subjected to real time RT-PCR. Eleven of these were significantly decreased in Group A with regard to Groups B and C. Among the dysregulated genes were MMP-7, CXCR4, PAEP and C4BPA. CONCLUSIONS: Repeated implantation failure in some oocyte recipients is associated with an intrinsic defect in the expression of multiple genes in their endometrium. Significantly decreased levels of several transcripts in endometria without manifest abnormalities is demonstrated for the first time and shown to be associated with implantation failure. JF - Human Reproduction AU - Tapia, Alejandro AU - Gangi, Lisa M AU - Zegers-Hochschild, Fernando AU - Balmaceda, Jose AU - Pommer, Ricardo AU - Trejo, Leon AU - Pacheco, Isabel Margarita AU - Salvatierra, Ana Maria AU - Henriquez, Soledad AU - Quezada, Marisol AU - Vargas, Macarena AU - Rios, Miguel AU - Munroe, David J AU - Croxatto, Horacio B AU - Velasquez, Luis AD - Departamento de Biologia, Universidad de Santiago de Chile, Santiago, Chile. Laboratory of Molecular Technology, National Cancer Institute-Science Applications International Corporation, Frederick, MD, USA. Unidad de Medicina Reproductiva, Clinica Las Condes, Santiago, Chile. Instituto de Investigaciones Materno-Infantil, Universidad de Chile, Santiago, Chile. Instituto Chileno de Medicina Reproductiva (ICMER), Santiago, Chile. Millenium Institute for Fundamental and Applied Biology, Santiago, Chile Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 340 EP - 351 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 2 SN - 0268-1161, 0268-1161 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Fertility KW - Endometrium KW - CXCR4 protein KW - Progesterone KW - Matrilysin KW - Transcription KW - Biopsy KW - DNA microarrays KW - Estradiol KW - Pregnancy KW - Gene expression KW - RNA KW - Oocytes KW - Polymerase chain reaction KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Differences+in+the+endometrial+transcript+profile+during+the+receptive+period+between+women+who+were+refractory+to+implantation+and+those+who+achieved+pregnancy&rft.au=Tapia%2C+Alejandro%3BGangi%2C+Lisa+M%3BZegers-Hochschild%2C+Fernando%3BBalmaceda%2C+Jose%3BPommer%2C+Ricardo%3BTrejo%2C+Leon%3BPacheco%2C+Isabel+Margarita%3BSalvatierra%2C+Ana+Maria%3BHenriquez%2C+Soledad%3BQuezada%2C+Marisol%3BVargas%2C+Macarena%3BRios%2C+Miguel%3BMunroe%2C+David+J%3BCroxatto%2C+Horacio+B%3BVelasquez%2C+Luis&rft.aulast=Tapia&rft.aufirst=Alejandro&rft.date=2008-02-01&rft.volume=23&rft.issue=2&rft.spage=340&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endometrium; Fertility; Progesterone; CXCR4 protein; Matrilysin; Transcription; Biopsy; DNA microarrays; Estradiol; Pregnancy; Gene expression; RNA; Polymerase chain reaction; Oocytes ER - TY - JOUR T1 - Protected aminooxyprolines for expedited library synthesis: Application to Tsg101-directed proline-oxime containing peptides AN - 19346702; 8684682 AB - The stereoselective synthesis of aminooxy-containing proline analogues bearing Fmoc/Boc or Fmoc/Mtt protection that renders them suitable for incorporation into peptides using Fmoc protocols is reported. Acid-catalyzed unmasking at the completion of peptide synthesis yields free aminooxy- functionalities for oxime formation through reaction with libraries of aldehydes. This allows post solid-phase diversification strategies that may facilitate structure-activity relationship studies. JF - Bioorganic and Medicinal Chemistry AU - Liu, Fa AU - Stephen, Andrew G AU - Fisher, Robert J AU - Burke, Terrence R AD - Laboratory of Medicinal Chemistry, CCR, NCI-Frederick, NIH, Building 376 Boyles Street, Frederick, MD 21702, USA, tburke@helix.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 1096 EP - 1101 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 3 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Proline KW - oximes KW - Aldehydes KW - Peptide synthesis KW - Structure-activity relationships KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19346702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Protected+aminooxyprolines+for+expedited+library+synthesis%3A+Application+to+Tsg101-directed+proline-oxime+containing+peptides&rft.au=Liu%2C+Fa%3BStephen%2C+Andrew+G%3BFisher%2C+Robert+J%3BBurke%2C+Terrence+R&rft.aulast=Liu&rft.aufirst=Fa&rft.date=2008-02-01&rft.volume=18&rft.issue=3&rft.spage=1096&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2007.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Proline; oximes; Peptide synthesis; Aldehydes; Structure-activity relationships DO - http://dx.doi.org/10.1016/j.bmcl.2007.12.003 ER - TY - JOUR T1 - Identification of a potent new chemotype for the selective inhibition of PDE4 AN - 19338415; 8684722 AB - A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4- b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure-activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented. JF - Bioorganic and Medicinal Chemistry AU - Skoumbourdis, Amanda P AU - Huang, Ruili AU - Southall, Noel AU - Leister, William AU - Guo, Vicky AU - Cho, Ming-Hsuang AU - Inglese, James AU - Nirenberg, Marshall AU - Austin, Christopher P AU - Xia, Menghang AU - Thomas, Craig J AD - NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370, USA, craigt@mail.nih.gov Y1 - 2008/02// PY - 2008 DA - Feb 2008 SP - 1297 EP - 1303 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 4 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - phosphodiesterase IV KW - Structure-activity relationships KW - phosphodiesterase KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19338415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Identification+of+a+potent+new+chemotype+for+the+selective+inhibition+of+PDE4&rft.au=Skoumbourdis%2C+Amanda+P%3BHuang%2C+Ruili%3BSouthall%2C+Noel%3BLeister%2C+William%3BGuo%2C+Vicky%3BCho%2C+Ming-Hsuang%3BInglese%2C+James%3BNirenberg%2C+Marshall%3BAustin%2C+Christopher+P%3BXia%2C+Menghang%3BThomas%2C+Craig+J&rft.aulast=Skoumbourdis&rft.aufirst=Amanda&rft.date=2008-02-01&rft.volume=18&rft.issue=4&rft.spage=1297&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmcl.2008.01.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Structure-activity relationships; phosphodiesterase IV; phosphodiesterase DO - http://dx.doi.org/10.1016/j.bmcl.2008.01.028 ER - TY - JOUR T1 - Ocular toxicity of fludarabine: a purine analog. AN - 1835541796; 18461151 AB - The purine analogs, fludarabine and cladribine represent an important class of chemotherapy agents used to treat a broad spectrum of lymphoid malignancies. Their toxicity profiles include dose-limiting myelosuppression, immunosuppression, opportunistic infection and severe neurotoxicity. This review summarizes the neurotoxicity of high- and standard-dose fludarabine, focusing on the clinical and pathological manifestations in the eye. The mechanisms of ocular toxicity are probably multifactorial. With increasing clinical use, an awareness of the neurological and ocular vulnerability, particularly to fludarabine, is important owing to the potential for life- and sight-threatening consequences. JF - Expert review of ophthalmology AU - Ding, Xiaoyan AU - Herzlich, Alexandra A AU - Bishop, Rachel AU - Tuo, Jingsheng AU - Chan, Chi-Chao AD - Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD, USA; And, Zhongshan Ophthalmic Center, Sun Yet-sen University, Guangzhou, China. Y1 - 2008/02// PY - 2008 DA - February 2008 SP - 97 EP - 109 VL - 3 IS - 1 SN - 1746-9899, 1746-9899 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835541796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+ophthalmology&rft.atitle=Ocular+toxicity+of+fludarabine%3A+a+purine+analog.&rft.au=Ding%2C+Xiaoyan%3BHerzlich%2C+Alexandra+A%3BBishop%2C+Rachel%3BTuo%2C+Jingsheng%3BChan%2C+Chi-Chao&rft.aulast=Ding&rft.aufirst=Xiaoyan&rft.date=2008-02-01&rft.volume=3&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+ophthalmology&rft.issn=17469899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2009-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The steroid receptor coactivator-3 is a tumor promoter in a mouse model of thyroid cancer. AN - 70258109; 17653082 AB - The molecular genetic events underlying thyroid carcinogenesis are not well understood. Mice harboring a dominant-negative mutant thyroid hormone receptor-beta (TRbeta(PV/PV) mice) spontaneously develop follicular thyroid carcinoma similar to human cancer. The present study aimed to elucidate the role of the steroid receptor coactivator-3 (SRC-3) in thyroid carcinogenesis in vivo by using the offspring from the cross of TRbeta(PV/PV) and SRC-3(-/-) mice. TRbeta(PV/PV) mice deficient in SRC-3 (TRbeta(PV/PV)SRC-3(-/-) mice) had significantly increased survival, decreased thyroid tumor growth, delayed tumor progression and lower incidence of distant metastasis as compared with TRbeta(PV/PV) mice with SRC-3 (TRbeta(PV/PV)SRC-3(+/+) mice). Further, in vivo and in vitro analyses of multiple signaling pathways indicated that SRC-3 deficiency could lead to (1) inhibition of cell cycle progression at the G(1)/S transition via controlling the expression of cell cycle regulators, such as E2F1; (2) induction of apoptosis by controlling the expression of the Bcl-2 and caspase-3 genes and (3) suppression of neovascularization and metastasis, at least in part, through modulating the vascular endothelial growth factor gene expression. Taken together, SRC-3 could play important roles through regulating multiple target genes and signaling pathways during thyroid carcinogenesis, understanding of which should direct future therapeutic options for thyroid cancer. JF - Oncogene AU - Ying, H AU - Willingham, M C AU - Cheng, S-Y AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2008/01/31/ PY - 2008 DA - 2008 Jan 31 SP - 823 EP - 830 VL - 27 IS - 6 KW - Proto-Oncogene Proteins c-bcl-2 KW - 0 KW - Thyroid Hormone Receptors beta KW - Trans-Activators KW - Histone Acetyltransferases KW - EC 2.3.1.48 KW - NCOA3 protein, human KW - Ncoa3 protein, mouse KW - Nuclear Receptor Coactivator 3 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Caspase 3 -- genetics KW - Animals KW - Mice, Mutant Strains KW - Apoptosis -- genetics KW - Neovascularization, Pathologic -- genetics KW - Disease Models, Animal KW - Mice KW - Thyroid Hormone Receptors beta -- genetics KW - Proto-Oncogene Proteins c-bcl-2 -- genetics KW - Cell Cycle -- genetics KW - Histone Acetyltransferases -- genetics KW - Gene Expression Regulation, Neoplastic KW - Thyroid Neoplasms -- genetics KW - Trans-Activators -- genetics KW - Adenocarcinoma, Follicular -- genetics KW - Histone Acetyltransferases -- physiology KW - Adenocarcinoma, Follicular -- pathology KW - Thyroid Neoplasms -- pathology KW - Trans-Activators -- physiology KW - Thyroid Neoplasms -- blood supply KW - Adenocarcinoma, Follicular -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70258109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=The+steroid+receptor+coactivator-3+is+a+tumor+promoter+in+a+mouse+model+of+thyroid+cancer.&rft.au=Ying%2C+H%3BWillingham%2C+M+C%3BCheng%2C+S-Y&rft.aulast=Ying&rft.aufirst=H&rft.date=2008-01-31&rft.volume=27&rft.issue=6&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-28 N1 - Date created - 2008-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. AN - 70246687; 18230780 AB - MicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer. No study has evaluated the association between microRNA expression patterns and colon cancer prognosis or therapeutic outcome. To identify microRNA expression patterns associated with colon adenocarcinomas, prognosis, or therapeutic outcome. MicroRNA microarray expression profiling of tumors and paired nontumorous tissues was performed on a US test cohort of 84 patients with incident colon adenocarcinoma, recruited between 1993 and 2002. We evaluated associations with tumor status, TNM staging, survival prognosis, and response to adjuvant chemotherapy. Associations were validated in a second, independent Chinese cohort of 113 patients recruited between 1991 and 2000, using quantitative reverse transcription polymerase chain reaction assays. The final date of follow-up was December 31, 2005, for the Maryland cohort and August 16, 2004, for the Hong Kong cohort. MicroRNAs that were differentially expressed in tumors and microRNA expression patterns associated with survival using cancer-specific death as the end point. RESULTS Thirty-seven microRNAs were differentially expressed in tumors from the test cohort. Selected for validation were miR-20a, miR-21, miR-106a, miR-181b, and miR-203, and all 5 were enriched in tumors from the validation cohort (P < .001). Higher miR-21 expression was present in adenomas (P = .006) and in tumors with more advanced TNM staging (P < .001). In situ hybridization demonstrated miR-21 to be expressed at high levels in colonic carcinoma cells. The 5-year cancer-specific survival rate was 57.5% for the Maryland cohort and was 49.5% for the Hong Kong cohort. High miR-21 expression was associated with poor survival in both the training (hazard ratio, 2.5; 95% confidence interval, 1.2-5.2) and validation cohorts (hazard ratio, 2.4; 95% confidence interval, 1.4-3.9), independent of clinical covariates, including TNM staging, and was associated with a poor therapeutic outcome. Expression patterns of microRNAs are systematically altered in colon adenocarcinomas. High miR-21 expression is associated with poor survival and poor therapeutic outcome. JF - JAMA AU - Schetter, Aaron J AU - Leung, Suet Yi AU - Sohn, Jane J AU - Zanetti, Krista A AU - Bowman, Elise D AU - Yanaihara, Nozomu AU - Yuen, Siu Tsan AU - Chan, Tsun Leung AU - Kwong, Dora L W AU - Au, Gordon K H AU - Liu, Chang-Gong AU - Calin, George A AU - Croce, Carlo M AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008/01/30/ PY - 2008 DA - 2008 Jan 30 SP - 425 EP - 436 VL - 299 IS - 4 KW - Biomarkers, Tumor KW - 0 KW - MIRN21 microRNA, human KW - MicroRNAs KW - RNA, Neoplasm KW - Abridged Index Medicus KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Prognosis KW - Aged KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression Profiling KW - In Situ Hybridization KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Chemotherapy, Adjuvant KW - Female KW - Male KW - Survival Analysis KW - Colonic Neoplasms -- genetics KW - Colonic Neoplasms -- mortality KW - Colonic Neoplasms -- drug therapy KW - Adenocarcinoma -- mortality KW - Adenocarcinoma -- genetics KW - MicroRNAs -- analysis KW - RNA, Neoplasm -- analysis KW - Colonic Neoplasms -- pathology KW - Adenocarcinoma -- drug therapy KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70246687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=MicroRNA+expression+profiles+associated+with+prognosis+and+therapeutic+outcome+in+colon+adenocarcinoma.&rft.au=Schetter%2C+Aaron+J%3BLeung%2C+Suet+Yi%3BSohn%2C+Jane+J%3BZanetti%2C+Krista+A%3BBowman%2C+Elise+D%3BYanaihara%2C+Nozomu%3BYuen%2C+Siu+Tsan%3BChan%2C+Tsun+Leung%3BKwong%2C+Dora+L+W%3BAu%2C+Gordon+K+H%3BLiu%2C+Chang-Gong%3BCalin%2C+George+A%3BCroce%2C+Carlo+M%3BHarris%2C+Curtis+C&rft.aulast=Schetter&rft.aufirst=Aaron&rft.date=2008-01-30&rft.volume=299&rft.issue=4&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/10.1001%2Fjama.299.4.425 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-01 N1 - Date created - 2008-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9 [12434020] Pharmacogenomics J. 2007 Oct;7(5):297-304 [17189960] Cell. 2003 Apr 4;113(1):25-36 [12679032] Curr Biol. 2003 Apr 29;13(9):790-5 [12725740] Mol Cancer Res. 2003 Oct;1(12):882-91 [14573789] Science. 2004 Jan 2;303(5654):83-6 [14657504] Cell. 2004 Jan 23;116(2):281-97 [14744438] J Mol Biol. 2004 May 28;339(2):327-35 [15136036] Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9740-4 [15210942] Stat Med. 1985 Jan-Mar;4(1):87-90 [3992076] Cell. 1990 Jun 1;61(5):759-67 [2188735] Cell. 1993 Dec 3;75(5):843-54 [8252621] Cell. 1993 Dec 3;75(5):855-62 [8252622] Nature. 2005 Jun 9;435(7043):828-33 [15944707] Nature. 2005 Jun 9;435(7043):834-8 [15944708] Dis Colon Rectum. 2005 Jun;48(6):1161-8 [15868237] Cancer Res. 2005 Jul 15;65(14):6029-33 [16024602] Cancer Res. 2005 Aug 15;65(16):7065-70 [16103053] N Engl J Med. 2005 Oct 27;353(17):1793-801 [16251535] Cancer Res. 2005 Nov 1;65(21):9628-32 [16266980] Nature. 2005 Dec 1;438(7068):685-9 [16258535] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Cancer Cell. 2006 Mar;9(3):189-98 [16530703] Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92 [16505370] Nat Rev Cancer. 2006 Apr;6(4):259-69 [16557279] Arch Med Res. 2006 May;37(4):548-51 [16624657] Gastroenterology. 2006 Jun;130(7):2113-29 [16762633] Mol Cancer. 2006;5:29 [16854228] Nat Genet. 2006 Sep;38(9):1060-5 [16878133] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18680-4 [17121985] Am J Respir Cell Mol Biol. 2007 Jan;36(1):8-12 [16917074] CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66 [17237035] Cancer Res. 2007 Feb 1;67(3):976-83 [17283129] Curr Mol Med. 2007 Feb;7(1):29-46 [17311531] Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2750-5 [17293455] Oncogene. 2007 Apr 26;26(19):2799-803 [17072344] JAMA. 2007 May 2;297(17):1901-8 [17473300] JAMA. 2007 May 2;297(17):1923-5 [17473304] J Biol Chem. 2007 May 11;282(19):14328-36 [17363372] Comment In: JAMA. 2008 Jun 11;299(22):2628; author reply 2628-9 [18544721] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/jama.299.4.425 ER - TY - JOUR T1 - Computer-aided drug discovery and development (CADDD): in silico-chemico-biological approach. AN - 70245677; 17229415 AB - It is generally recognized that drug discovery and development are very time and resources consuming processes. There is an ever growing effort to apply computational power to the combined chemical and biological space in order to streamline drug discovery, design, development and optimization. In biomedical arena, computer-aided or in silico design is being utilized to expedite and facilitate hit identification, hit-to-lead selection, optimize the absorption, distribution, metabolism, excretion and toxicity profile and avoid safety issues. Commonly used computational approaches include ligand-based drug design (pharmacophore, a 3D spatial arrangement of chemical features essential for biological activity), structure-based drug design (drug-target docking), and quantitative structure-activity and quantitative structure-property relationships. Regulatory agencies as well as pharmaceutical industry are actively involved in development of computational tools that will improve effectiveness and efficiency of drug discovery and development process, decrease use of animals, and increase predictability. It is expected that the power of CADDD will grow as the technology continues to evolve. JF - Chemico-biological interactions AU - Kapetanovic, I M AD - Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Building, Suite 2117, MSC 7322, Bethesda, MD 20892-7322, United States. kapetani@mail.nih.gov Y1 - 2008/01/30/ PY - 2008 DA - 2008 Jan 30 SP - 165 EP - 176 VL - 171 IS - 2 SN - 0009-2797, 0009-2797 KW - Index Medicus KW - Quantitative Structure-Activity Relationship KW - Computer-Aided Design KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70245677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Computer-aided+drug+discovery+and+development+%28CADDD%29%3A+in+silico-chemico-biological+approach.&rft.au=Kapetanovic%2C+I+M&rft.aulast=Kapetanovic&rft.aufirst=I&rft.date=2008-01-30&rft.volume=171&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-05 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chem Inf Comput Sci. 2004 Mar-Apr;44(2):480-8 [15032527] J Med Chem. 2004 Apr 8;47(8):1962-8 [15055996] Curr Pharm Des. 2004;10(9):1011-33 [15078130] Bioorg Med Chem. 2004 May 15;12(10):2553-70 [15110838] J Med Chem. 2004 May 20;47(11):2750-60 [15139753] Curr Opin Chem Biol. 2004 Jun;8(3):255-63 [15183323] Proteins. 2004 Aug 1;56(2):235-49 [15211508] Nat Rev Drug Discov. 2004 Aug;3(8):660-72 [15286733] Nat Rev Drug Discov. 2004 Aug;3(8):711-5 [15286737] Curr Opin Chem Biol. 2004 Aug;8(4):349-58 [15288243] Mini Rev Med Chem. 2004 Dec;4(10):1053-65 [15579113] J Bioinform Comput Biol. 2003 Apr;1(1):169-77 [15290786] Curr Opin Drug Discov Devel. 2004 Jul;7(4):396-403 [15338948] Proteins. 2004 Nov 1;57(2):225-42 [15340911] Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9 [15341953] J Med Chem. 2004 Oct 7;47(21):5021-40 [15456246] Nat Biotechnol. 2004 Oct;22(10):1215-7 [15470453] Nat Biotechnol. 2004 Oct;22(10):1253-9 [15470465] Nat Rev Drug Discov. 2004 Nov;3(11):935-49 [15520816] J Med Chem. 1964 Nov;7:691-4 [14262788] Regul Toxicol Pharmacol. 2004 Dec;40(3):185-206 [15546675] J Chem Inf Comput Sci. 2004 Nov-Dec;44(6):2157-66 [15554686] J Med Chem. 2004 Dec 2;47(25):6248-54 [15566295] J Med Chem. 2000 Jul 13;43(14):2664-74 [10893304] Biochim Biophys Acta. 2001 Feb 9;1545(1-2):67-77 [11342032] J Med Chem. 2002 May 23;45(11):2213-21 [12014959] Nat Rev Drug Discov. 2002 Jul;1(7):551-5 [12120261] Drug Discov Today. 2003 Feb 15;8(4):175-83 [12581712] J Med Chem. 2003 Feb 27;46(5):716-26 [12593652] Nat Rev Drug Discov. 2003 Mar;2(3):192-204 [12612645] Prog Med Chem. 2003;41:61-97 [12774691] Bioorg Med Chem Lett. 2003 Jul 21;13(14):2399-403 [12824043] Curr Opin Drug Discov Devel. 2003 May;6(3):370-6 [12833670] Bioorg Med Chem. 2003 Aug 5;11(16):3457-74 [12878140] Nat Rev Drug Discov. 2003 Aug;2(8):665-8 [12904816] J Med Chem. 2003 Sep 11;46(19):3953-6 [12954047] J Med Chem. 2003 Oct 9;46(21):4377-92 [14521403] Bioorg Med Chem Lett. 2003 Dec 15;13(24):4355-9 [14643325] Curr Med Chem. 2004 Jan;11(1):71-90 [14754427] Curr Med Chem. 2004 Jan;11(1):91-107 [14754428] Drug Discov Today. 2004 Feb 1;9(3):127-35 [14960390] Science. 2004 Mar 19;303(5665):1813-8 [15031495] Nature. 2004 Dec 16;432(7019):855-61 [15602551] Nature. 2004 Dec 16;432(7019):862-5 [15602552] J Med Chem. 2005 Feb 24;48(4):962-76 [15715466] Curr Pharm Des. 2005;11(3):323-33 [15723628] J Med Chem. 2005 Apr 7;48(7):2534-47 [15801843] Environ Sci Technol. 2005 Apr 1;39(7):2188-99 [15871254] Nat Rev Drug Discov. 2005 Jun;4(6):461-7 [15915152] Planta Med. 2005 May;71(5):399-405 [15931575] Drug Discov Today. 2005 Jul 1;10(13):895-907 [15993809] Mini Rev Med Chem. 2005 Jul;5(7):677-83 [16026314] Curr Opin Chem Biol. 2005 Aug;9(4):400-6 [16006180] Nat Rev Drug Discov. 2005 Aug;4(8):649-63 [16056391] J Med Chem. 2005 Oct 6;48(20):6250-60 [16190752] J Pharmacol Toxicol Methods. 2006 Jan-Feb;53(1):38-66 [16054403] Curr Drug Discov Technol. 2004 Jan;1(1):61-76 [16472220] Curr Drug Discov Technol. 2005 Jun;2(2):55-67 [16472230] Curr Drug Discov Technol. 2005 Sep;2(3):185-93 [16472227] Regul Toxicol Pharmacol. 2006 Mar;44(2):97-110 [16352383] Bioorg Med Chem. 2006 Apr 15;14(8):2627-35 [16378729] Drug Discov Today. 2006 Feb;11(3-4):127-32 [16533710] Drug Discov Today. 2006 Feb;11(3-4):149-59 [16533713] J Chem Inf Model. 2006 Mar-Apr;46(2):728-35 [16563003] Drug Discov Today. 2006 Apr;11(7-8):326-33 [16580974] J Med Chem. 2006 May 4;49(9):2703-12 [16640330] J Chem Inf Model. 2006 May-Jun;46(3):1236-44 [16711743] J Med Chem. 2006 Jun 1;49(11):3116-35 [16722631] J Med Chem. 2006 Jun 1;49(11):3278-86 [16722646] J Med Chem. 2006 Jun 15;49(12):3478-84 [16759090] Curr Med Chem. 2006;13(13):1491-507 [16787200] Med Chem. 2006 Jan;2(1):89-112 [16787359] J Med Chem. 2006 Jun 29;49(13):3759-62 [16789731] Proteins. 2006 Aug 1;64(2):422-35 [16708364] Drug Discov Today. 2006 Jul;11(13-14):580-94 [16793526] Curr Pharm Des. 2006;12(17):2099-110 [16796558] Toxicology. 2006 Jul 5;224(1-2):156-62 [16707203] J Med Chem. 2006 Jul 27;49(15):4526-34 [16854058] Curr Opin Chem Biol. 2006 Aug;10(4):294-302 [16822703] Mol Biosyst. 2006 Jun;2(6-7):288-91 [16880946] Drug Discov Today. 2006 Sep;11(17-18):806-11 [16935748] J Mol Biol. 2006 Oct 13;363(1):174-87 [16952371] J Med Chem. 2006 Oct 5;49(20):5851-5 [17004700] J Med Chem. 2006 Oct 5;49(20):5912-31 [17004707] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Excretion of Delta9-tetrahydrocannabinol in sweat. AN - 70197864; 17481836 AB - Sweat testing is a noninvasive technique for monitoring drug exposure over a 7-day period in treatment, criminal justice, and employment settings. We evaluated Delta(9)-tetrahydrocannabinol (THC) excretion in 11 daily cannabis users after cessation of drug use. PharmChek sweat patches worn for 7 days were analyzed for THC by gas chromatography-mass spectrometry (GC/MS). The limit of quantification (LOQ) for the method was 0.4 ng THC/patch. Sweat patches worn the first week of continuously monitored abstinence had THC above the United States Substance Abuse Mental Health Services Administration's proposed cutoff concentration for federal workplace testing of 1 ng THC/patch. Mean+/-S.E.M. THC concentrations were 3.85+/-0.86 ng THC/patch. Eight of 11 subjects had negative patches the second week and one produced THC positive patches for 4 weeks of monitored abstinence. We also tested daily and weekly sweat patches from seven subjects who were administered oral doses of up to 14.8 mg THC/day for five consecutive days. In this oral THC administration study, no daily or weekly patches had THC above the LOQ; concurrent plasma THC concentrations were all less than 6.1 microg/L. In conclusion, using proposed federal cutoff concentrations, most daily cannabis users will have a positive sweat patch in the first week after ceasing drug use and a negative patch after subsequent weeks, although patches may remain positive for 4 weeks or more. Oral ingestion of up to 14.8 mg THC daily does not produce a THC positive sweat patch test. JF - Forensic science international AU - Huestis, Marilyn A AU - Scheidweiler, Karl B AU - Saito, Takeshi AU - Fortner, Neil AU - Abraham, Tsadik AU - Gustafson, Richard A AU - Smith, Michael L AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. mhuestis@intra.nida.nih.gov Y1 - 2008/01/30/ PY - 2008 DA - 2008 Jan 30 SP - 173 EP - 177 VL - 174 IS - 2-3 KW - Psychotropic Drugs KW - 0 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Administration, Oral KW - Double-Blind Method KW - Substance Abuse Detection KW - Humans KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Forensic Toxicology KW - Time Factors KW - Male KW - Female KW - Dronabinol -- analysis KW - Sweat -- chemistry KW - Marijuana Abuse -- diagnosis KW - Psychotropic Drugs -- analysis KW - Psychotropic Drugs -- administration & dosage KW - Dronabinol -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70197864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forensic+science+international&rft.atitle=Excretion+of+Delta9-tetrahydrocannabinol+in+sweat.&rft.au=Huestis%2C+Marilyn+A%3BScheidweiler%2C+Karl+B%3BSaito%2C+Takeshi%3BFortner%2C+Neil%3BAbraham%2C+Tsadik%3BGustafson%2C+Richard+A%3BSmith%2C+Michael+L&rft.aulast=Huestis&rft.aufirst=Marilyn&rft.date=2008-01-30&rft.volume=174&rft.issue=2-3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Forensic+science+international&rft.issn=1872-6283&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chem. 2006 Aug;52(8):1539-45 [16740647] Clin Chem. 2005 Nov;51(11):2085-94 [16166169] J Anal Toxicol. 2004 Nov-Dec;28(8):667-73 [15538962] J Anal Toxicol. 1998 Oct;22(6):445-54 [9788519] J Anal Toxicol. 1997 Oct;21(6):451-8 [9323525] J Anal Toxicol. 1996 Oct;20(6):398-403 [8889675] J Anal Toxicol. 1992 Sep-Oct;16(5):276-82 [1338215] Ther Drug Monit. 2006 Aug;28(4):545-51 [16885723] J Chromatogr B Biomed Sci Appl. 1999 Oct 15;733(1-2):119-26 [10572977] J Chromatogr B Biomed Sci Appl. 1999 Oct 15;733(1-2):247-64 [10572984] J Anal Toxicol. 2000 Oct;24(7):509-21 [11043653] J Anal Toxicol. 2000 Oct;24(7):557-61 [11043659] Forensic Sci Int. 2001 Feb 15;116(2-3):89-106 [11182260] Forensic Sci Int. 2002 Aug 14;128(1-2):90-7 [12208028] J Forensic Sci. 2002 Nov;47(6):1380-7 [12455668] Addiction. 2003 Mar;98(3):317-24 [12603231] Forensic Sci Int. 2003 Apr 23;133(1-2):63-78 [12742691] Clin Chem. 2003 Jul;49(7):1114-24 [12816908] Addict Biol. 2003 Jun;8(2):191-200 [12850778] J Anal Toxicol. 2003 Jul-Aug;27(5):294-303 [12908943] Clin Pharmacokinet. 2004;43(3):157-85 [14871155] J Anal Toxicol. 2004 May-Jun;28(4):253-9 [15189676] Clin Chem. 2004 Nov;50(11):2083-90 [15271860] Beitr Gerichtl Med. 1990;48:45-9 [2241828] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Enabling the Molecular Medicine Revolution through Network-Centric Biomedicine. T2 - 2008 Keystone Symposia on Tolerance in Transplantation and Autoimmunity (A8) AN - 40779555; 4787205 JF - 2008 Keystone Symposia on Tolerance in Transplantation and Autoimmunity (A8) AU - Buetow, Ken H Y1 - 2008/01/29/ PY - 2008 DA - 2008 Jan 29 KW - Bioindicators KW - Bioinformatics KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40779555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Tolerance+in+Transplantation+and+Autoimmunity+%28A8%29&rft.atitle=Enabling+the+Molecular+Medicine+Revolution+through+Network-Centric+Biomedicine.&rft.au=Buetow%2C+Ken+H&rft.aulast=Buetow&rft.aufirst=Ken&rft.date=2008-01-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Tolerance+in+Transplantation+and+Autoimmunity+%28A8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=93 1&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of the eIF2 Kinase PKR. T2 - 2008 Keystone Symposia on Translational Regulatory Mechanisms (A7) AN - 40723176; 4762588 JF - 2008 Keystone Symposia on Translational Regulatory Mechanisms (A7) AU - Dever, Thomas E Y1 - 2008/01/28/ PY - 2008 DA - 2008 Jan 28 KW - Translation KW - Models KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40723176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Translational+Regulatory+Mechanisms+%28A7%29&rft.atitle=Regulation+of+the+eIF2+Kinase+PKR.&rft.au=Dever%2C+Thomas+E&rft.aulast=Dever&rft.aufirst=Thomas&rft.date=2008-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Translational+Regulatory+Mechanisms+%28A7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functions of eIF1, eIF1A, and 18S rRNA in Preinitation Complex Assembly and AUG Selection. T2 - 2008 Keystone Symposia on Translational Regulatory Mechanisms (A7) AN - 40720110; 4762570 JF - 2008 Keystone Symposia on Translational Regulatory Mechanisms (A7) AU - Hinnebusch, Alan G Y1 - 2008/01/28/ PY - 2008 DA - 2008 Jan 28 KW - RRNA 18S KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Translational+Regulatory+Mechanisms+%28A7%29&rft.atitle=Functions+of+eIF1%2C+eIF1A%2C+and+18S+rRNA+in+Preinitation+Complex+Assembly+and+AUG+Selection.&rft.au=Hinnebusch%2C+Alan+G&rft.aulast=Hinnebusch&rft.aufirst=Alan&rft.date=2008-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Translational+Regulatory+Mechanisms+%28A7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advances in Antibody-Based Chip Separation Technologies in Biomarker Research T2 - 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers and 10th International Symposium on Advances in Extraction Techniques (HTC - ExTech 10) AN - 40683375; 4746668 JF - 10th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers and 10th International Symposium on Advances in Extraction Techniques (HTC - ExTech 10) AU - Phillips, T M AU - Kalish, H AU - Wellner, E F Y1 - 2008/01/28/ PY - 2008 DA - 2008 Jan 28 KW - Bioindicators KW - Technology KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40683375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Symposium+on+Hyphenated+Techniques+in+Chromatography+and+Hyphenated+Chromatographic+Analyzers+and+10th+International+Symposium+on+Advances+in+Extraction+Techniques+%28HTC+-+ExTech+10%29&rft.atitle=Advances+in+Antibody-Based+Chip+Separation+Technologies+in+Biomarker+Research&rft.au=Phillips%2C+T+M%3BKalish%2C+H%3BWellner%2C+E+F&rft.aulast=Phillips&rft.aufirst=T&rft.date=2008-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Symposium+on+Hyphenated+Techniques+in+Chromatography+and+Hyphenated+Chromatographic+Analyzers+and+10th+International+Symposium+on+Advances+in+Extraction+Techniques+%28HTC+-+ExTech+10%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ordibo.be/htc/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characteristics of Bipolar Patients Attending Geriatric Clinic in South India T2 - 3rd Biennial Conference of the International Society for Bipolar Disorders (ISBD 2008) AN - 40730518; 4762824 JF - 3rd Biennial Conference of the International Society for Bipolar Disorders (ISBD 2008) AU - Prakash, O AU - Varghese, M AU - Bharath, S AU - Shivakumar, P T AU - Kumar, B Sashan Y1 - 2008/01/27/ PY - 2008 DA - 2008 Jan 27 KW - India KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40730518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Biennial+Conference+of+the+International+Society+for+Bipolar+Disorders+%28ISBD+2008%29&rft.atitle=Characteristics+of+Bipolar+Patients+Attending+Geriatric+Clinic+in+South+India&rft.au=Prakash%2C+O%3BVarghese%2C+M%3BBharath%2C+S%3BShivakumar%2C+P+T%3BKumar%2C+B+Sashan&rft.aulast=Prakash&rft.aufirst=O&rft.date=2008-01-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Biennial+Conference+of+the+International+Society+for+Bipolar+Disorders+%28ISBD+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isbd/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predictors of Remission from Manic Episode Treated with Electroconvulsive Therapy T2 - 3rd Biennial Conference of the International Society for Bipolar Disorders (ISBD 2008) AN - 40728073; 4762832 JF - 3rd Biennial Conference of the International Society for Bipolar Disorders (ISBD 2008) AU - Thirthalli, J AU - Hiremani, R M AU - Tharayil, B S AU - Gangadhar, B N Y1 - 2008/01/27/ PY - 2008 DA - 2008 Jan 27 KW - Remission KW - ECS KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40728073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Biennial+Conference+of+the+International+Society+for+Bipolar+Disorders+%28ISBD+2008%29&rft.atitle=Predictors+of+Remission+from+Manic+Episode+Treated+with+Electroconvulsive+Therapy&rft.au=Thirthalli%2C+J%3BHiremani%2C+R+M%3BTharayil%2C+B+S%3BGangadhar%2C+B+N&rft.aulast=Thirthalli&rft.aufirst=J&rft.date=2008-01-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Biennial+Conference+of+the+International+Society+for+Bipolar+Disorders+%28ISBD+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isbd/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. AN - 70173104; 18054789 AB - Perturbed DNA replication either activates a cell cycle checkpoint, which halts DNA replication, or decreases the rate of DNA synthesis without activating a checkpoint. Here we report that at low doses, replication inhibitors did not activate a cell cycle checkpoint, but they did activate a process that required functional Bloom's syndrome-associated (BLM) helicase, Mus81 nuclease and ataxia telangiectasia mutated and Rad3-related (ATR) kinase to induce transient double-stranded DNA breaks. The induction of transient DNA breaks was accompanied by dissociation of proliferating cell nuclear antigen (PCNA) and DNA polymerase alpha from replication forks. In cells with functional BLM, Mus81 and ATR, the transient breaks were promptly repaired and DNA continued to replicate at a slow pace in the presence of replication inhibitors. In cells that lacked BLM, Mus81, or ATR, transient breaks did not form, DNA replication did not resume, and exposure to low doses of replication inhibitors was toxic. These observations suggest that BLM helicase, ATR kinase, and Mus81 nuclease are required to convert perturbed replication forks to DNA breaks when cells encounter conditions that decelerate DNA replication, thereby leading to the rapid repair of those breaks and resumption of DNA replication without incurring DNA damage and without activating a cell cycle checkpoint. JF - Journal of molecular biology AU - Shimura, Tsutomu AU - Torres, Michael J AU - Martin, Melvenia M AU - Rao, V Ashutosh AU - Pommier, Yves AU - Katsura, Mari AU - Miyagawa, Kiyoshi AU - Aladjem, Mirit I AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892-4255, USA. Y1 - 2008/01/25/ PY - 2008 DA - 2008 Jan 25 SP - 1152 EP - 1164 VL - 375 IS - 4 KW - DNA-Binding Proteins KW - 0 KW - H2AFX protein, human KW - Histones KW - Proliferating Cell Nuclear Antigen KW - Aphidicolin KW - 38966-21-1 KW - DNA KW - 9007-49-2 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Endonucleases KW - EC 3.1.- KW - MUS81 protein, human KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Comet Assay KW - Fibroblasts -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Hydrogen Peroxide -- pharmacology KW - DNA -- analysis KW - Bloom Syndrome -- genetics KW - Bloom Syndrome -- metabolism KW - DNA Replication -- drug effects KW - Aphidicolin -- pharmacology KW - Fluorescent Antibody Technique, Direct KW - Phosphorylation KW - Cells, Cultured KW - Kinetics KW - Histones -- metabolism KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Endonucleases -- metabolism KW - DNA Helicases -- metabolism KW - DNA Helicases -- genetics KW - DNA Breaks, Double-Stranded KW - DNA Helicases -- deficiency KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70173104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Bloom%27s+syndrome+helicase+and+Mus81+are+required+to+induce+transient+double-strand+DNA+breaks+in+response+to+DNA+replication+stress.&rft.au=Shimura%2C+Tsutomu%3BTorres%2C+Michael+J%3BMartin%2C+Melvenia+M%3BRao%2C+V+Ashutosh%3BPommier%2C+Yves%3BKatsura%2C+Mari%3BMiyagawa%2C+Kiyoshi%3BAladjem%2C+Mirit+I&rft.aulast=Shimura&rft.aufirst=Tsutomu&rft.date=2008-01-25&rft.volume=375&rft.issue=4&rft.spage=1152&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-29 N1 - Date created - 2008-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biol. 2001 Sep 3;154(5):913-23 [11535615] Science. 2003 Jun 6;300(5625):1542-8 [12791985] J Cell Biol. 2002 Apr 1;157(1):19-30 [11916980] Oncogene. 2002 Apr 11;21(16):2525-33 [11971187] Cancer Biol Ther. 2003 May-Jun;2(3):233-5 [12878854] Biochem Cell Biol. 2003 Jun;81(3):123-9 [12897845] EMBO J. 2003 Aug 15;22(16):4325-36 [12912929] Trends Cell Biol. 2003 Sep;13(9):493-501 [12946629] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] Mol Cell. 2003 Sep;12(3):747-59 [14527419] J Cell Biol. 2003 Oct 27;163(2):245-55 [14581453] Mol Biol Cell. 2003 Dec;14(12):4826-34 [14638871] Oncogene. 2003 Nov 27;22(54):8749-57 [14647470] Mol Cell Biol. 2004 Feb;24(3):1279-91 [14729972] J Biol Chem. 2004 May 7;279(19):20067-75 [14982920] J Cell Biol. 2004 Jun 21;165(6):801-12 [15197177] J Cell Biol. 2004 Sep 13;166(6):801-13 [15364958] EMBO J. 2004 Sep 15;23(18):3667-76 [15329670] Proc Natl Acad Sci U S A. 1974 Nov;71(11):4508-12 [4140506] Nature. 1978 Oct 5;275(5679):458-60 [692726] Nucleic Acids Res. 1980 Jan 25;8(2):377-87 [6775308] Cancer Res. 1982 Sep;42(9):3810-3 [6809314] Biochemistry. 1991 Sep 3;30(35):8590-7 [1909569] Int J Radiat Biol. 1994 Jul;66(1):23-8 [8027608] EMBO J. 2005 Jan 26;24(2):405-17 [15616582] Cancer Res. 2005 Apr 1;65(7):2526-31 [15805243] Mol Biol Cell. 2005 May;16(5):2372-81 [15743907] Mol Cell Biol. 2005 Oct;25(20):8925-37 [16199871] Cancer Res. 2006 Feb 1;66(3):1675-83 [16452227] Nucleic Acids Res. 2006;34(3):880-92 [16456034] Cancer Res. 2006 Feb 15;66(4):2233-41 [16489026] J Biol Chem. 2006 Aug 11;281(32):22839-46 [16766518] EMBO J. 2006 Oct 18;25(20):4921-32 [17036055] Annu Rev Genet. 2006;40:363-83 [16895466] J Mol Biol. 2007 Mar 30;367(3):665-80 [17280685] Genes Dev. 2007 Apr 15;21(8):898-903 [17437996] Nat Struct Mol Biol. 2007 Jul;14(7):677-9 [17603497] Mol Cancer Res. 2007 Jul;5(7):713-24 [17634426] Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9891-6 [16788066] Mol Cell. 1999 Dec;4(6):983-93 [10635323] J Biol Chem. 2000 Aug 4;275(31):23500-8 [10825162] J Cell Biol. 2001 Apr 16;153(2):367-80 [11309417] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Nat Genet. 2003 Apr;33(4):497-501 [12640452] Mol Cell. 2001 Nov;8(5):1117-27 [11741546] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of IS200/IS605 Family DNA Transposases: Activation and Transposon-Directed Target Site Selection AN - 20948644; 8098556 AB - The smallest known DNA transposases are those from the IS200/IS605 family. Here we show how the interplay of protein and DNA activates TnpA, the Helicobacter pylori IS608 transposase, for catalysis. First, transposon end binding causes a conformational change that aligns catalytically important protein residues within the active site. Subsequent precise cleavage at the left and right ends, the steps that liberate the transposon from its donor site, does not involve a site-specific DNA-binding domain. Rather, cleavage site recognition occurs by complementary base pairing with a TnpA-bound subterminal transposon DNA segment. Thus, the enzyme active site is constructed from elements of both protein and DNA, reminiscent of the interdependence of protein and RNA in the ribosome. Our structural results explain why the transposon ends are asymmetric and how the transposon selects a target site for integration, and they allow us to propose a molecular model for the entire transposition reaction. JF - Cell AU - Barabas, O AU - Ronning AU - Guynet, C AU - Hickman, AB AU - Ton-Hoang, B AU - Chandler, M AU - Dyda, F AD - National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, fred.dyda@nih.gov Y1 - 2008/01/25/ PY - 2008 DA - 2008 Jan 25 SP - 208 EP - 220 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 132 IS - 2 SN - 0092-8674, 0092-8674 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Helicobacter pylori KW - Molecular modelling KW - Transposition KW - Enzymes KW - Ribosomes KW - Transposons KW - Site selection KW - transposase KW - Integration KW - RNA KW - DNA KW - Catalysis KW - J 02330:Biochemistry KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20948644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Mechanism+of+IS200%2FIS605+Family+DNA+Transposases%3A+Activation+and+Transposon-Directed+Target+Site+Selection&rft.au=Barabas%2C+O%3BRonning%3BGuynet%2C+C%3BHickman%2C+AB%3BTon-Hoang%2C+B%3BChandler%2C+M%3BDyda%2C+F&rft.aulast=Barabas&rft.aufirst=O&rft.date=2008-01-25&rft.volume=132&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/10.1016%2Fj.cell.2007.12.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Site selection; Transposons; Integration; Molecular modelling; transposase; RNA; Transposition; DNA; Enzymes; Ribosomes; Catalysis; Helicobacter pylori DO - http://dx.doi.org/10.1016/j.cell.2007.12.029 ER - TY - JOUR T1 - Expression of POTE protein in human testis detected by novel monoclonal antibodies AN - 20589045; 7940382 AB - The POTE gene family is composed of 13 highly homologous paralogs preferentially expressed in prostate, ovary, testis, and placenta. We produced 10 monoclonal antibodies (MAbs) against three representative POTE paralogs: POTE-21, POTE-2 gamma C, and POTE-22. One reacted with all three paralogs, six MAbs reacted with POTE-2 gamma C and POTE-22, and three MAbs were specific to POTE-21. Epitopes of all 10 MAbs were located in the cysteine-rich repeats (CRRs) motifs located at the N-terminus of each POTE paralog. Testing the reactivity of each MAb with 12 different CRRs revealed slight differences among the antigenic determinants, which accounts for differences in cross-reactivity. Using MAbs HP8 and PG5 we were able to detect a POTE-actin fusion protein in human testis by immunoprecipitation followed by Western blotting. By immunohistochemistry we demonstrated that the POTE protein is expressed in primary spermatocytes, implying a role in spermatogenesis. JF - Biochemical and Biophysical Research Communications AU - Ise, T AU - Das, S AU - Nagata, S AU - Maeda, H AU - Lee, Y AU - Onda, M AU - Anver, M R AU - Bera, T K AU - Pastan, I AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA, pastani@mail.nih.gov Y1 - 2008/01/25/ PY - 2008 DA - 2008 Jan 25 SP - 603 EP - 608 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 365 IS - 4 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Testes KW - Western blotting KW - Cross-reactivity KW - Monoclonal antibodies KW - Immunoprecipitation KW - Spermatogenesis KW - Spermatocytes KW - N-Terminus KW - potE gene KW - Placenta KW - Antigenic determinants KW - Fusion protein KW - Ovaries KW - Prostate KW - Immunohistochemistry KW - Epitopes KW - F 06935:Development, Aging & Organ Systems KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20589045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Expression+of+POTE+protein+in+human+testis+detected+by+novel+monoclonal+antibodies&rft.au=Ise%2C+T%3BDas%2C+S%3BNagata%2C+S%3BMaeda%2C+H%3BLee%2C+Y%3BOnda%2C+M%3BAnver%2C+M+R%3BBera%2C+T+K%3BPastan%2C+I&rft.aulast=Ise&rft.aufirst=T&rft.date=2008-01-25&rft.volume=365&rft.issue=4&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.10.195 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Western blotting; Cross-reactivity; Monoclonal antibodies; Immunoprecipitation; Spermatogenesis; Spermatocytes; N-Terminus; potE gene; Antigenic determinants; Placenta; Ovaries; Fusion protein; Immunohistochemistry; Prostate; Epitopes DO - http://dx.doi.org/10.1016/j.bbrc.2007.10.195 ER - TY - CPAPER T1 - The Search for Type 2 Diabetes and Obesity Susceptibility Genes in Pima Indians. T2 - 2008 Keystone Symposia on Diabetes Mellitus, Insulin Action and Resistance (A6) AN - 40723056; 4762597 JF - 2008 Keystone Symposia on Diabetes Mellitus, Insulin Action and Resistance (A6) AU - Baier, Leslie J Y1 - 2008/01/22/ PY - 2008 DA - 2008 Jan 22 KW - Obesity KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40723056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Diabetes+Mellitus%2C+Insulin+Action+and+Resistance+%28A6%29&rft.atitle=The+Search+for+Type+2+Diabetes+and+Obesity+Susceptibility+Genes+in+Pima+Indians.&rft.au=Baier%2C+Leslie+J&rft.aulast=Baier&rft.aufirst=Leslie&rft.date=2008-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Diabetes+Mellitus%2C+Insulin+Action+and+Resistance+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=92 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Identification of a mutation in the SV40 capsid protein VP1 that influences plaque morphology, vacuolization, and receptor usage. AN - 70108107; 17936868 AB - A plaque variant of SV40 that was first isolated in the 1960s, designated SV40-LP(KT), was molecularly cloned and subjected to sequence analysis. The genome of SV40-LP(KT) was found to be nearly identical to the previously described isolate known as 777. However, SV40-LP(KT) contained a mutation in the VP1 coding region resulting in a change of histidine 136 to tyrosine. This VP1 mutation was identified as a genetic determinant influencing a number of phenotypes associated with SV40-LP(KT) such as plaque morphology, intracellular vacuole formation, and ganglioside receptor usage. JF - Virology AU - Murata, Haruhiko AU - Peden, Keith AU - Lewis, Andrew M AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 SP - 343 EP - 351 VL - 370 IS - 2 SN - 0042-6822, 0042-6822 KW - Capsid Proteins KW - 0 KW - Gangliosides KW - Receptors, Virus KW - VP1 protein, polyomavirus KW - Index Medicus KW - Animals KW - Gangliosides -- physiology KW - Viral Plaque Assay KW - Models, Molecular KW - Protein Structure, Quaternary KW - Mutagenesis, Site-Directed KW - Phenotype KW - Microscopy, Electron, Transmission KW - Receptors, Virus -- physiology KW - Cells, Cultured KW - Cercopithecus aethiops KW - Vacuoles -- virology KW - Amino Acid Substitution KW - Cell Line KW - Simian virus 40 -- genetics KW - Simian virus 40 -- pathogenicity KW - Genes, Viral KW - Capsid Proteins -- physiology KW - Mutation KW - Capsid Proteins -- genetics KW - Simian virus 40 -- physiology KW - Capsid Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70108107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Identification+of+a+mutation+in+the+SV40+capsid+protein+VP1+that+influences+plaque+morphology%2C+vacuolization%2C+and+receptor+usage.&rft.au=Murata%2C+Haruhiko%3BPeden%2C+Keith%3BLewis%2C+Andrew+M&rft.aulast=Murata&rft.aufirst=Haruhiko&rft.date=2008-01-20&rft.volume=370&rft.issue=2&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-20 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - DNA Vaccines Developed for Emerging Infectious Diseases Induce Neutralizing Antibody and Cellular Immune Responses in Healthy Adults. T2 - 2008 Keystone Symposia on Viral Immunity (A5) AN - 40721086; 4762547 JF - 2008 Keystone Symposia on Viral Immunity (A5) AU - Martin, Julie Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 KW - Vaccines KW - Antibodies KW - DNA vaccines KW - Infectious diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=DNA+Vaccines+Developed+for+Emerging+Infectious+Diseases+Induce+Neutralizing+Antibody+and+Cellular+Immune+Responses+in+Healthy+Adults.&rft.au=Martin%2C+Julie&rft.aulast=Martin&rft.aufirst=Julie&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Stoichiometry of Antibody-Mediated Neutralization of West Nile Virus: Implications for Vaccine Development and Immune Escape T2 - 2008 Keystone Symposia on Viral Immunity (A5) AN - 40720445; 4762509 JF - 2008 Keystone Symposia on Viral Immunity (A5) AU - Pierson, Theodore C Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 KW - Vaccines KW - Neutralization KW - Disease control KW - West Nile virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=The+Stoichiometry+of+Antibody-Mediated+Neutralization+of+West+Nile+Virus%3A+Implications+for+Vaccine+Development+and+Immune+Escape&rft.au=Pierson%2C+Theodore+C&rft.aulast=Pierson&rft.aufirst=Theodore&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Host Factors Involved in the Control of Viral Infections T2 - 2008 Keystone Symposia on Viral Immunity (A5) AN - 40719792; 4762532 JF - 2008 Keystone Symposia on Viral Immunity (A5) AU - Rehermann, Barbara Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 KW - Infection KW - Viral diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=Host+Factors+Involved+in+the+Control+of+Viral+Infections&rft.au=Rehermann%2C+Barbara&rft.aulast=Rehermann&rft.aufirst=Barbara&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunotherapy for Chronic Viral Infection T2 - 2008 Keystone Symposia on Viral Immunity (A5) AN - 40719169; 4762533 JF - 2008 Keystone Symposia on Viral Immunity (A5) AU - Hasenkrug, Kim J Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 KW - Immunotherapy KW - Infection KW - Chronic infection KW - Viral diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=Immunotherapy+for+Chronic+Viral+Infection&rft.au=Hasenkrug%2C+Kim+J&rft.aulast=Hasenkrug&rft.aufirst=Kim&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respiratory Syncytial Virus (RSV) Infects and Matures Primary Dendritic Cells and DC-Sign/R Binds RSV Attachment Glycoprotein but is not Required for Infection T2 - 2008 Keystone Symposia on Viral Immunity (A5) AN - 40717100; 4762519 JF - 2008 Keystone Symposia on Viral Immunity (A5) AU - Johnson, Teresa R Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 KW - Glycoproteins KW - Infection KW - Dendritic cells KW - DC-SIGN protein KW - Respiration KW - Metabolism KW - Respiratory syncytial virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=Respiratory+Syncytial+Virus+%28RSV%29+Infects+and+Matures+Primary+Dendritic+Cells+and+DC-Sign%2FR+Binds+RSV+Attachment+Glycoprotein+but+is+not+Required+for+Infection&rft.au=Johnson%2C+Teresa+R&rft.aulast=Johnson&rft.aufirst=Teresa&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intravital Imaging of Anti-Viral CD8+ T Cell Activation T2 - 2008 Keystone Symposia on Viral Immunity (A5) AN - 40716307; 4762512 JF - 2008 Keystone Symposia on Viral Immunity (A5) AU - Yewdell, Jonathan W Y1 - 2008/01/20/ PY - 2008 DA - 2008 Jan 20 KW - Antiviral agents KW - CD8 antigen KW - Imaging techniques KW - Lymphocytes T KW - Cell activation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40716307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.atitle=Intravital+Imaging+of+Anti-Viral+CD8%2B+T+Cell+Activation&rft.au=Yewdell%2C+Jonathan+W&rft.aulast=Yewdell&rft.aufirst=Jonathan&rft.date=2008-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Viral+Immunity+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=94 4&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. AN - 70198227; 17993459 AB - Leptin plays a pivotal role in the regulation of energy homeostasis and metabolism, primarily by acting on neurons in the hypothalamus that control food intake. However, leptin receptors are more widely expressed in the brain suggesting additional, as yet unknown, functions of leptin. Here we show that both embryonic and adult hippocampal neurons express leptin receptors coupled to activation of STAT3 and phosphatidylinositol 3-kinase-Akt signaling pathways. Leptin protects hippocampal neurons against cell death induced by neurotrophic factor withdrawal and excitotoxic and oxidative insults. The neuroprotective effect of leptin is antagonized by the JAK2-STAT3 inhibitor AG-490, STAT3 decoy DNA, and phosphatidylinositol 3-kinase/Akt inhibitors but not by an inhibitor of MAPK. Leptin induces the production of manganese superoxide dismutase and the anti-apoptotic protein Bcl-xL, and stabilizes mitochondrial membrane potential and lessens mitochondrial oxidative stress. Leptin receptor-deficient mice (db/db mice) are more vulnerable to seizure-induced hippocampal damage, and intraventricular administration of leptin protects neurons against seizures. By enhancing mitochondrial resistance to apoptosis and excitotoxicity, our findings suggest that leptin signaling serves a neurotrophic function in the developing and adult hippocampus. JF - The Journal of biological chemistry AU - Guo, Zhihong AU - Jiang, Haiyang AU - Xu, Xiangru AU - Duan, Wenzhen AU - Mattson, Mark P AD - Laboratory of Neurosciences and National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. Y1 - 2008/01/18/ PY - 2008 DA - 2008 Jan 18 SP - 1754 EP - 1763 VL - 283 IS - 3 SN - 0021-9258, 0021-9258 KW - Leptin KW - 0 KW - Neuroprotective Agents KW - Neurotoxins KW - Receptors, Leptin KW - STAT3 Transcription Factor KW - bcl-X Protein KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Janus Kinases KW - EC 2.7.10.2 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Seizures -- chemically induced KW - Animals KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Receptors, Leptin -- metabolism KW - Superoxide Dismutase -- metabolism KW - Mice KW - Neurotoxins -- toxicity KW - bcl-X Protein -- metabolism KW - Neuroprotective Agents -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Membrane Potential, Mitochondrial -- drug effects KW - Cell Survival -- drug effects KW - Up-Regulation -- drug effects KW - Enzyme Activation -- drug effects KW - Mice, Inbred C57BL KW - Oxidative Stress -- drug effects KW - Male KW - Janus Kinases -- metabolism KW - Neurons -- drug effects KW - Mitochondria -- enzymology KW - Signal Transduction -- drug effects KW - Neurons -- cytology KW - Mitochondria -- drug effects KW - Hippocampus -- cytology KW - Neurons -- enzymology KW - Hippocampus -- enzymology KW - STAT3 Transcription Factor -- metabolism KW - Leptin -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70198227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Leptin-mediated+cell+survival+signaling+in+hippocampal+neurons+mediated+by+JAK+STAT3+and+mitochondrial+stabilization.&rft.au=Guo%2C+Zhihong%3BJiang%2C+Haiyang%3BXu%2C+Xiangru%3BDuan%2C+Wenzhen%3BMattson%2C+Mark+P&rft.aulast=Guo&rft.aufirst=Zhihong&rft.date=2008-01-18&rft.volume=283&rft.issue=3&rft.spage=1754&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. AN - 70207096; 18182616 AB - Patients with Birt-Hogg-Dubé (BHD) syndrome harbor germline mutations in the BHD tumor suppressor gene that are associated with an increased risk for kidney cancer. BHD encodes folliculin, a protein that may interact with the energy- and nutrient-sensing 5'-AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signaling pathways. We used recombineering methods to generate mice with a conditional BHD allele and introduced the cadherin 16 (KSP)-Cre transgene to target BHD inactivation to the kidney. Kidney cell proliferation was measured by BrdU incorporation and phospho-histone H3 staining. Kidney weight data were analyzed with Wilcoxon's rank-sum, Student's t, and Welch's t tests. Hematoxylin and eosin staining and immunoblot analysis and immunohistochemistry of cell cycle and signaling proteins were performed on mouse kidney cells and tissues. BHD knockout mice and kidney cells isolated from BHD knockout and control mice were treated with the mTOR inhibitor rapamycin. Mouse survival was evaluated by Kaplan-Meier analyses. All statistical tests were two-sided. BHD knockout mice developed enlarged polycystic kidneys and died from renal failure by 3 weeks of age. Targeted BHD knockout led to the activation of Raf-extracellular signal-regulated protein kinase (Erk)1/2 and Akt-mTOR pathways in the kidneys and increased expression of cell cycle proteins and cell proliferation. Rapamycin-treated BHD knockout mice had smaller kidneys than buffer-treated BHD knockout mice had (n = 4-6 mice per group, relative kidney/body weight ratios, mean = 4.64% vs 12.2%, difference = 7.6%, 95% confidence interval = 5.2% to 10.0%; P < .001) and longer median survival time (n = 4-5 mice per group, 41.5 vs 23 days; P = .0065 ). Homozygous loss of BHD may initiate renal tumorigenesis in the mouse. The conditional BHD knockout mouse may be a useful research model for dissecting multistep kidney carcinogenesis, and rapamycin may be considered as a potential treatment for Birt-Hogg-Dubé syndrome. JF - Journal of the National Cancer Institute AU - Baba, Masaya AU - Furihata, Mutsuo AU - Hong, Seung-Beom AU - Tessarollo, Lino AU - Haines, Diana C AU - Southon, Eileen AU - Patel, Vishal AU - Igarashi, Peter AU - Alvord, W Gregory AU - Leighty, Robert AU - Yao, Masahiro AU - Bernardo, Marcelino AU - Ileva, Lilia AU - Choyke, Peter AU - Warren, Michelle B AU - Zbar, Berton AU - Linehan, W Marston AU - Schmidt, Laura S AD - Urologic Oncology Branch, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2008/01/16/ PY - 2008 DA - 2008 Jan 16 SP - 140 EP - 154 VL - 100 IS - 2 KW - Antibiotics, Antineoplastic KW - 0 KW - Bhd protein, mouse KW - Proto-Oncogene Proteins KW - Tumor Suppressor Proteins KW - Estrone KW - 2DI9HA706A KW - Protein Kinases KW - EC 2.7.- KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - mTOR protein, mouse KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Animals KW - Immunoblotting KW - Random Allocation KW - Disease Models, Animal KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Knockout KW - Genotype KW - Kaplan-Meier Estimate KW - Antibiotics, Antineoplastic -- pharmacology KW - Blotting, Southern KW - Estrone -- genetics KW - Syndrome KW - Sirolimus -- pharmacology KW - Signal Transduction -- drug effects KW - Germ-Line Mutation KW - Fluorescent Antibody Technique KW - Immunohistochemistry KW - Cell Proliferation -- drug effects KW - Kidney Neoplasms -- genetics KW - Kidney Neoplasms -- pathology KW - Kidney -- metabolism KW - Kidney -- pathology KW - Polycystic Kidney Diseases -- metabolism KW - Gene Silencing KW - Tumor Suppressor Proteins -- genetics KW - Kidney -- drug effects KW - Polycystic Kidney Diseases -- genetics KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Protein Kinases -- metabolism KW - Polycystic Kidney Diseases -- complications KW - Mitogen-Activated Protein Kinase 3 -- drug effects KW - Protein Kinases -- drug effects KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Kidney Neoplasms -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- drug effects KW - Proto-Oncogene Proteins -- genetics KW - Polycystic Kidney Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70207096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Kidney-targeted+Birt-Hogg-Dube+gene+inactivation+in+a+mouse+model%3A+Erk1%2F2+and+Akt-mTOR+activation%2C+cell+hyperproliferation%2C+and+polycystic+kidneys.&rft.au=Baba%2C+Masaya%3BFurihata%2C+Mutsuo%3BHong%2C+Seung-Beom%3BTessarollo%2C+Lino%3BHaines%2C+Diana+C%3BSouthon%2C+Eileen%3BPatel%2C+Vishal%3BIgarashi%2C+Peter%3BAlvord%2C+W+Gregory%3BLeighty%2C+Robert%3BYao%2C+Masahiro%3BBernardo%2C+Marcelino%3BIleva%2C+Lilia%3BChoyke%2C+Peter%3BWarren%2C+Michelle+B%3BZbar%2C+Berton%3BLinehan%2C+W+Marston%3BSchmidt%2C+Laura+S&rft.aulast=Baba&rft.aufirst=Masaya&rft.date=2008-01-16&rft.volume=100&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjm288 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-28 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Dermatol. 1977 Dec;113(12):1674-7 [596896] J Biol Chem. 2007 Aug 24;282(34):24583-90 [17556368] Virchows Arch B Cell Pathol Incl Mol Pathol. 1988;56(3):185-9 [2464871] Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56(4):237-45 [2565618] Cell. 1996 Oct 18;87(2):159-70 [8861899] Nature. 1997 Apr 24;386(6627):761, 763 [9126728] Cold Spring Harb Symp Quant Biol. 1997;62:159-68 [9598348] Am J Physiol. 1999 Jun;276(6 Pt 2):F825-36 [10362771] Arch Dermatol. 1999 Oct;135(10):1195-202 [10522666] Proc Natl Acad Sci U S A. 2000 May 9;97(10):5434-9 [10779555] Am J Physiol Renal Physiol. 2000 Jul;279(1):F195-202 [10894802] Genomics. 2001 Apr 1;73(1):56-65 [11352566] Nat Rev Genet. 2001 Oct;2(10):769-79 [11584293] Jpn J Cancer Res. 2001 Nov;92(11):1147-9 [11714437] Cancer Epidemiol Biomarkers Prev. 2002 Apr;11(4):393-400 [11927500] J Am Soc Nephrol. 2002 Jul;13(7):1824-36 [12089378] J Am Soc Nephrol. 2002 Jul;13(7):1837-46 [12089379] Cancer Cell. 2002 Aug;2(2):157-64 [12204536] Am J Surg Pathol. 2002 Dec;26(12):1542-52 [12459621] J Med Genet. 2002 Dec;39(12):906-12 [12471204] Hum Mutat. 2003 Sep;22(3):183-98 [12938083] Curr Biol. 2003 Oct 14;13(20):1775-85 [14561402] Hum Mol Genet. 2003 Dec 1;12(23):3043-53 [14532326] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2023-7 [14769940] Nat Rev Mol Cell Biol. 2004 Feb;5(2):89-99 [15040442] Genes Dev. 2004 Jul 1;18(13):1533-8 [15231735] Curr Biol. 2004 Sep 21;14(18):1650-6 [15380067] J Am Soc Nephrol. 2005 Jan;16(1):46-51 [15563559] Nat Genet. 2005 Jan;37(1):19-24 [15624019] J Urol. 2005 May;173(5):1482-6 [15821464] Am J Hum Genet. 2005 Jun;76(6):1023-33 [15852235] J Natl Cancer Inst. 2005 Jun 15;97(12):931-5 [15956655] J Clin Invest. 2005 Jul;115(7):1756-64 [16007252] Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R251-8 [16244323] Lab Invest. 2006 Jul;86(7):664-75 [16652107] Nat Rev Cancer. 2006 Sep;6(9):729-34 [16915295] Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15552-7 [17028174] J Urol. 2007 Jan;177(1):346-52 [17162089] J Pathol. 2007 Apr;211(5):524-31 [17323425] Oncogene. 2007 May 14;26(22):3291-310 [17496923] Vet Pathol. 1985 Sep;22(5):447-55 [4049673] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jnci/djm288 ER - TY - JOUR T1 - Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma. AN - 70191528; 17959855 AB - Arsenic trioxide (ATO) induces remission in 85% of adults with refractory acute promyelocytic leukemia (APL). We conducted a phase 1 trial of ATO in children (median age 13 y, range, 2-19) with refractory leukemia. ATO was administered intravenously over 2 hours, 5 d/wk for 20 doses/cycle. Patients with APL (n=13) received 0.15 mg/kg per day, and patients with other types of leukemia received 0.15 mg/kg per day (n=2) or 0.2 mg/kg per day (n=4). Nineteen of the 24 enrolled patients were fully evaluable for toxicity. At 0.15 mg/kg per day, 2 of 15 patients experienced dose-limiting corrected QT interval (QTc) prolongation, pneumonitis, or neuropathic pain. At 0.2 mg/kg per day, 2 of 4 patients had dose-limiting QTc prolongation or pancreatitis. Non-dose-limiting toxicities included elevated serum transaminases, nausea, vomiting, abdominal pain, constipation, electrolyte imbalance, hyperglycemia, dermatitis, and headache. At 0.15 mg/kg per day, the median (range) plasma arsenic maximum concentration (Cmax) was 0.28 microM (0.11-0.37 microM) and at 0.2 mg/kg per day, Cmax was 0.40 and 0.46 microM; area under the concentration times time curve (AUC0-24) was 2.50 microM-hr (1.28-3.85 microM-hr) and 4.37 microM-hr and 4.69 microM-hr, respectively. Morphologic complete response (CR) was achieved in 85% of patients with APL; no responses were observed in non-APL patients. ATO is well-tolerated in children at the recommended dose of 0.15 mg/kg per day. The response rate in children with relapsed APL is similar to the response rate in adults. This trial was registered as #NCT00020111 at www.ClinicalTrials.gov. JF - Blood AU - Fox, Elizabeth AU - Razzouk, Bassem I AU - Widemann, Brigitte C AU - Xiao, Shaun AU - O'Brien, Michelle AU - Goodspeed, Wendy AU - Reaman, Gregory H AU - Blaney, Susan M AU - Murgo, Anthony J AU - Balis, Frank M AU - Adamson, Peter C AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 566 EP - 573 VL - 111 IS - 2 SN - 0006-4971, 0006-4971 KW - Antineoplastic Agents KW - 0 KW - Arsenicals KW - Oxides KW - arsenic trioxide KW - S7V92P67HO KW - Abridged Index Medicus KW - Index Medicus KW - Nausea -- drug therapy KW - Humans KW - Vomiting -- chemically induced KW - Water-Electrolyte Balance -- drug effects KW - Child KW - Vomiting -- drug therapy KW - Hyperglycemia -- drug therapy KW - Dermatitis -- etiology KW - Adult KW - Headache -- drug therapy KW - Adolescent KW - Time Factors KW - Male KW - Pancreatitis -- drug therapy KW - Pneumonia -- chemically induced KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Constipation -- chemically induced KW - Constipation -- drug therapy KW - Pneumonia -- drug therapy KW - Recurrence KW - Child, Preschool KW - Nausea -- chemically induced KW - Headache -- chemically induced KW - Hyperglycemia -- chemically induced KW - Abdominal Pain -- chemically induced KW - Female KW - Dermatitis -- drug therapy KW - Abdominal Pain -- drug therapy KW - Pancreatitis -- chemically induced KW - Oxides -- adverse effects KW - Leukemia, Promyelocytic, Acute -- drug therapy KW - Arsenicals -- pharmacokinetics KW - Antineoplastic Agents -- pharmacokinetics KW - Oxides -- pharmacokinetics KW - Lymphoma -- drug therapy KW - Lymphoma -- complications KW - Leukemia, Promyelocytic, Acute -- complications KW - Arsenicals -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70191528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Phase+1+trial+and+pharmacokinetic+study+of+arsenic+trioxide+in+children+and+adolescents+with+refractory+or+relapsed+acute+leukemia%2C+including+acute+promyelocytic+leukemia+or+lymphoma.&rft.au=Fox%2C+Elizabeth%3BRazzouk%2C+Bassem+I%3BWidemann%2C+Brigitte+C%3BXiao%2C+Shaun%3BO%27Brien%2C+Michelle%3BGoodspeed%2C+Wendy%3BReaman%2C+Gregory+H%3BBlaney%2C+Susan+M%3BMurgo%2C+Anthony+J%3BBalis%2C+Frank+M%3BAdamson%2C+Peter+C&rft.aulast=Fox&rft.aufirst=Elizabeth&rft.date=2008-01-15&rft.volume=111&rft.issue=2&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2008-01-09 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00020111; ClinicalTrials.gov N1 - SuppNotes - Cited By: Blood. 1999 Nov 15;94(10):3315-24 [10552940] Leuk Lymphoma. 2004 Dec;45(12):2387-401 [15621751] J Clin Oncol. 2000 Jul;18(13):2620-5 [10893295] Blood. 2001 Jul 15;98(2):266-71 [11435292] J Clin Oncol. 2001 Sep 15;19(18):3852-60 [11559723] Eur J Clin Pharmacol. 2002 Nov;58(8):521-6 [12451429] J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003 Jan;38(1):165-83 [12635825] Cancer. 2003 May 1;97(9):2218-24 [12712474] J Biol Chem. 2003 Aug 22;278(34):31998-2004 [12767976] J Clin Oncol. 2003 Oct 1;21(19):3609-15 [14512391] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83 [15070760] Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5328-35 [15044693] Blood. 2004 May 1;103(9):3496-502 [14701702] Clin Chem. 1992 Dec;38(12):2479-83 [1458588] Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3978-83 [9108090] Blood. 1997 May 1;89(9):3345-53 [9129041] Blood. 1997 May 1;89(9):3354-60 [9129042] J Natl Cancer Inst. 1998 Jan 21;90(2):124-33 [9450572] N Engl J Med. 1998 Nov 5;339(19):1341-8 [9801394] Cancer Res. 1999 Jul 1;59(13):3053-8 [10397243] Blood. 1999 Sep 15;94(6):2102-11 [10477740] Blood. 2000 Jan 1;95(1):90-5 [10607690] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Do adjuvant aromatase inhibitors increase the cardiovascular risk in postmenopausal women with early breast cancer? Meta-analysis of randomized trials. AN - 70190559; 18041059 AB - Despite the advantages from using aromatase inhibitors (AIs) compared with tamoxifen for early breast cancer, an unexpectedly greater number of grade 3 and 4 cardiovascular events (CVAE) (as defined by National Cancer Institute of Canada-Common Toxicity Criteria [version 2.0] was demonstrated. Phase 3 randomized clinical trials (RCTs) comparing AI with tamoxifen in early breast cancer were considered eligible for this review. The event-based risk ratios (RRs) with 95% confidence intervals (95% CIs) were derived, and a test of heterogeneity was applied. Finally, absolute differences (ADs) in event rates and the number of patients needed to harm 1 patient (NNH) were determined. Seven eligible RCTs (19,818 patients) reported CVAE results. When considering all RCTs, the AD of the primary endpoint (CVAE) between the 2 arms (0.52%), tamoxifen versus AI, was statistically significant (RR, 1.31; 95% CI, 1.07-1.60; P= .007). This translated into an NNH value of 189 patients; when only third-generation AIs were considered, the difference (0.57%) remained significant (RR, 1.34; 95% CI, 1.09-1.63; P= .0038). Thromboembolic events were significantly more frequent in the tamoxifen arm, regardless of the strategy adopted (RR, 0.53; 95% CI, 0.42-0.65; P< .0001), without significant heterogeneity (P= .21). An AD of 1.17% and an NNH value of 85 patients were observed. According to the results from this meta-analysis, the risk of grade 3 and 4 CVAEs in patients who were receiving AIs was higher compared with the risk in patients who were receiving tamoxifen, and the difference reached statistical significance. However, the AD was relatively low, and from 160 to 180 patients had to be treated to produce 1 event. JF - Cancer AU - Cuppone, Federica AU - Bria, Emilio AU - Verma, Sunil AU - Pritchard, Kathleen I AU - Gandhi, Sonal AU - Carlini, Paolo AU - Milella, Michele AU - Nisticò, Cecilia AU - Terzoli, Edmondo AU - Cognetti, Francesco AU - Giannarelli, Diana AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 260 EP - 267 VL - 112 IS - 2 SN - 0008-543X, 0008-543X KW - Aromatase Inhibitors KW - 0 KW - Tamoxifen KW - 094ZI81Y45 KW - Abridged Index Medicus KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Postmenopause KW - Humans KW - Tamoxifen -- adverse effects KW - Middle Aged KW - Female KW - Breast Neoplasms -- drug therapy KW - Cardiovascular Diseases -- chemically induced KW - Aromatase Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70190559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Do+adjuvant+aromatase+inhibitors+increase+the+cardiovascular+risk+in+postmenopausal+women+with+early+breast+cancer%3F+Meta-analysis+of+randomized+trials.&rft.au=Cuppone%2C+Federica%3BBria%2C+Emilio%3BVerma%2C+Sunil%3BPritchard%2C+Kathleen+I%3BGandhi%2C+Sonal%3BCarlini%2C+Paolo%3BMilella%2C+Michele%3BNistic%C3%B2%2C+Cecilia%3BTerzoli%2C+Edmondo%3BCognetti%2C+Francesco%3BGiannarelli%2C+Diana&rft.aulast=Cuppone&rft.aufirst=Federica&rft.date=2008-01-15&rft.volume=112&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2008-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence. AN - 70165502; 17585886 AB - A history of alcohol dependence recruits increased voluntary alcohol intake and sensitivity to stress. Corticotropin-releasing hormone (CRH) has been implicated in this transition, but underlying molecular mechanisms remain unclear. A postdependent state was induced using intermittent alcohol exposure. Experiments were carried out following > or =3 weeks of recovery to eliminate contributions of acute withdrawal. Voluntary alcohol consumption was assessed in a two-bottle, free choice procedure. Behavioral sensitivity to stress was examined using fear suppression of behavior in a punished drinking (Vogel) conflict test. Effects of forced swim stress on voluntary alcohol intake were examined as a function of exposure history. Expression of Crh, Crhr1, and Crhr2 transcripts was analyzed by in situ hybridization histochemistry. Alcohol drinking was upregulated long-term following a history of dependence. Fear suppression of behavior was selectively potentiated in postdependent animals. This persisted 3 months after alcohol exposure and was reversed by the selective CRH-R1 antagonist 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (MTIP) (10 mg/kg). Forced swim stress increased alcohol intake in postdependent animals but not in control animals. Behavioral changes were paralleled by an upregulation of Crhr1 transcript expression within basolateral (BLA) and medial (MeA) amygdala and Crh messenger RNA (mRNA) in central amygdala (CeA). In contrast, Crhr2 expression was down in the BLA. Neuroadaptations encompassing amygdala CRH signaling contribute to the behavioral phenotype of postdependent animals. JF - Biological psychiatry AU - Sommer, Wolfgang H AU - Rimondini, Roberto AU - Hansson, Anita C AU - Hipskind, Philip A AU - Gehlert, Donald R AU - Barr, Christina S AU - Heilig, Markus A AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism/National Institutes of Health, Bethesda, Maryland 20892-1108, USA. Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 139 EP - 145 VL - 63 IS - 2 KW - 3-(4-chloro-2-morpholin-4-ylthiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethylimidazo(1,2-b)pyridazine KW - 0 KW - CRF receptor type 1 KW - Pyridazines KW - Receptors, Corticotropin-Releasing Hormone KW - Thiazoles KW - Index Medicus KW - Thiazoles -- pharmacology KW - Rats KW - Gene Expression -- drug effects KW - Behavior, Animal -- drug effects KW - Animals KW - Pyridazines -- pharmacology KW - In Situ Hybridization -- methods KW - Rats, Wistar KW - Disease Models, Animal KW - Gene Expression -- physiology KW - Time Factors KW - Male KW - Amygdala -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- metabolism KW - Stress, Physiological -- pathology KW - Alcohol Drinking -- physiopathology KW - Amygdala -- drug effects KW - Alcoholism -- physiopathology KW - Stress, Physiological -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70165502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Upregulation+of+voluntary+alcohol+intake%2C+behavioral+sensitivity+to+stress%2C+and+amygdala+crhr1+expression+following+a+history+of+dependence.&rft.au=Sommer%2C+Wolfgang+H%3BRimondini%2C+Roberto%3BHansson%2C+Anita+C%3BHipskind%2C+Philip+A%3BGehlert%2C+Donald+R%3BBarr%2C+Christina+S%3BHeilig%2C+Markus+A&rft.aulast=Sommer&rft.aufirst=Wolfgang&rft.date=2008-01-15&rft.volume=63&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-27 N1 - Date created - 2007-12-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Withdrawal of penicillamine from zinc sulphate-penicillamine maintenance therapy in Wilson's disease: promising, safe and cheap. AN - 70087315; 17765927 AB - Penicillamine, once considered the cornerstone of treatment for Wilson disease (WD), is rather expensive and toxic, and often causes neurological worsening. Zinc sulphate, aiming at the treatment of free-copper toxicosis, has emerged as effective, safe and cheap alternative. To assess the effect of withdrawal of penicillamine from maintenance treatment with penicillamine and zinc sulphate. 45 patients of WD (M:F: 28:17; age at diagnosis: 13.5+/-63 years), on both penicillamine (P) and zinc sulphate (Zn), couldn't continue penicillamine due to financial constraints. Their clinical data, disability and impairment scores (Schwab and England (S&E) score, Neurological Symptom Score (NSS), and Chu staging) and follow-up data of patients maintained only on zinc sulphate were recorded. Majority of patients (84.4%) had neuropsychiatric manifestations. The mean duration of treatment with penicillamine (P) and zinc sulphate (P+Zn), before stopping penicillamine, was 107.4+/-67.3 months. 40 patients improved variably, while the rest didn't. They received only zinc sulphate for 27.2+/-8.5 months (range: 12 to 34) and 44 patients (97.7%) remained status quo or improved marginally. Only one patient reported worsening in dysarthria. Their disability and impairment scores during combination (penicillamine and zinc sulphate) and Zn alone were: Chu (1.3+/-0.5 vs. 1.5+/-1.9; p=0.4), NSS (1.8+/-3.1 vs. 1.5+/-2.3; p=0.03) and S&E (96.4+/-5.6 vs. 98.6+/-3.5; p=0.03). There were no adverse effects. Withdrawal of penicillamine from zinc sulphate/penicillamine maintenance therapy for patients with Wilson's disease was effective, safe and economic, for almost all patients. This retrospective study reiterates that zinc sulphate may be used as a preferred mode of treatment for patients with Wilson's disease. JF - Journal of the neurological sciences AU - Sinha, S AU - Taly, A B AD - National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore - 560 029, India. sanjib_sinha2004@yahoo.co.in Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 129 EP - 132 VL - 264 IS - 1-2 SN - 0022-510X, 0022-510X KW - Astringents KW - 0 KW - Chelating Agents KW - Zinc Sulfate KW - 7733-02-0 KW - Copper KW - 789U1901C5 KW - Penicillamine KW - GNN1DV99GX KW - Index Medicus KW - Neurocognitive Disorders -- metabolism KW - Chelation Therapy -- adverse effects KW - Astringents -- administration & dosage KW - Humans KW - Copper -- metabolism KW - Retrospective Studies KW - Child KW - Chelating Agents -- adverse effects KW - Child, Preschool KW - Chelating Agents -- administration & dosage KW - Adult KW - Treatment Outcome KW - Astringents -- economics KW - Adolescent KW - Copper -- toxicity KW - Chelation Therapy -- economics KW - Male KW - Female KW - Chelating Agents -- economics KW - Neurocognitive Disorders -- physiopathology KW - Neurocognitive Disorders -- chemically induced KW - Chelation Therapy -- methods KW - Penicillamine -- adverse effects KW - Penicillamine -- administration & dosage KW - Zinc Sulfate -- economics KW - Hepatolenticular Degeneration -- metabolism KW - Zinc Sulfate -- administration & dosage KW - Hepatolenticular Degeneration -- physiopathology KW - Hepatolenticular Degeneration -- drug therapy KW - Penicillamine -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70087315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+neurological+sciences&rft.atitle=Withdrawal+of+penicillamine+from+zinc+sulphate-penicillamine+maintenance+therapy+in+Wilson%27s+disease%3A+promising%2C+safe+and+cheap.&rft.au=Sinha%2C+S%3BTaly%2C+A+B&rft.aulast=Sinha&rft.aufirst=S&rft.date=2008-01-15&rft.volume=264&rft.issue=1-2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+neurological+sciences&rft.issn=0022510X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2007-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Pathways for Arterial Specification in Zebrafish T2 - 2008 Keystone Symposium on Molecular Mechanisms of Angiogenesis in Development and Disease (J5) AN - 40715934; 4762447 JF - 2008 Keystone Symposium on Molecular Mechanisms of Angiogenesis in Development and Disease (J5) AU - Weinstein, Brant M Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 KW - Freshwater fish KW - Danio rerio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposium+on+Molecular+Mechanisms+of+Angiogenesis+in+Development+and+Disease+%28J5%29&rft.atitle=Pathways+for+Arterial+Specification+in+Zebrafish&rft.au=Weinstein%2C+Brant+M&rft.aulast=Weinstein&rft.aufirst=Brant&rft.date=2008-01-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposium+on+Molecular+Mechanisms+of+Angiogenesis+in+Development+and+Disease+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=91 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis AN - 20891449; 8090246 AB - Because of their similarity to humans, non-human primates constitute useful preclinical models in which to examine potential human drug toxicities. Antiretroviral nucleoside reverse transcriptase inhibitor (NRTI) toxicity is currently under investigation in Erythrocebus patas monkeys, and whereas NRTI pharmacokinetics have been studied in other monkey species, pharmacokinetics for Zidovudine plus Lamivudine (AZT/3TC) dosing have not been reported in the patas. Here we present 24 h serum pharmacokinetic parameters after a single oral exposure to the combination of AZT (40 mg) and 3TC (24 mg), doses equivalent to a human daily dose of Combivir(R). The patas (n=3) AZT/3TC pharmacokinetic profiles were similar to those seen in other primate species. Average maximum serum concentrations (C sub(m) sub(a) sub(x)) for AZT and 3TC were 2.35 and 2.65 mu g /ml, respectively, and were observed at 0.83 h (T sub(m) sub(a) sub(x)). C sub(m) sub(a) sub(x) was 13.34 mu g/ml for the AZT-glucuronide (AZT-G) and was 0.023 mu g/ml for the potentially toxic minor metabolite 3'-amino-3'-deoxythymidine (AMT), both occurring at about 1 h after dosing. Similar elimination half-times, 0.70 and 0.68 h super(-) super(1), were found for AZT and AZT-G, respectively, while 3TC was eliminated about half as fast (0.33 h super(-) super(1)) resulting in AUC sub(() sub(0) sub(-) sub( arrow down )d) values of 6.97 mu g/ml h for 3TC, 2.99 mu g/ml h for AZT, 20.5 mu g/ml h for AZT-G and 0.002 for AMT 6.97 mu g/ml h. This study shows similar metabolism and pharmacokinetics for oral administration of AZT/3TC in the adult patas monkey, other primate species and humans. The data validate the use of the patas monkey for studies of NRTI toxicity. half parent drug and metabolites JF - Toxicology and Applied Pharmacology AU - Divi, R L AU - Doerge AU - Twaddle, N C AU - Shockley, ME AU - St Claire, MC AU - Harbaugh, J W AU - Harbaugh, S W AU - Poirier, M C AD - LCBG, CCR, National Cancer Institute, Bldg. 37. Rm. 4032 NIH, 37 Convent Drive, Bethesda, MD 20892-4255, USA, poirierm@exchange.nih.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 206 EP - 211 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 226 IS - 2 SN - 0041-008X, 0041-008X KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Oral administration KW - Zidovudine KW - Lamivudine KW - Metabolites KW - Erythrocebus patas KW - Toxicity KW - Primates KW - Drugs KW - Pharmacokinetics KW - Metabolism KW - nucleoside reverse transcriptase inhibitors KW - X 24310:Pharmaceuticals KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20891449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Metabolism+and+pharmacokinetics+of+the+combination+Zidovudine+plus+Lamivudine+in+the+adult+Erythrocebus+patas+monkey+determined+by+liquid+chromatography-tandem+mass+spectrometric+analysis&rft.au=Divi%2C+R+L%3BDoerge%3BTwaddle%2C+N+C%3BShockley%2C+ME%3BSt+Claire%2C+MC%3BHarbaugh%2C+J+W%3BHarbaugh%2C+S+W%3BPoirier%2C+M+C&rft.aulast=Divi&rft.aufirst=R&rft.date=2008-01-15&rft.volume=226&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2007.09.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Oral administration; Lamivudine; Zidovudine; Metabolites; Toxicity; Drugs; Metabolism; Pharmacokinetics; nucleoside reverse transcriptase inhibitors; Erythrocebus patas; Primates DO - http://dx.doi.org/10.1016/j.taap.2007.09.007 ER - TY - JOUR T1 - Risk of testicular germ-cell tumours in relation to childhood physical activity AN - 20620530; 8074890 AB - The US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study of testicular germ-cell tumours (TGCTs) enrolled participants and their mothers in 2002-2005. Hours of sports or vigorous childhood physical activity per week were ascertained for three time periods; 1st-5th grades, 6th-8th grades and 9th-12th grades. Son- and mother-reports were analysed separately and included 539 control son-mother pairs and 499 case son-mother pairs. Odds ratios and 95% confidence intervals were produced. The analysis of the sons' responses found no relationship between childhood physical activity and TGCT, while the mothers' analysis found an inverse association, which was solely due to nonseminoma. Future studies should seek to validate responses further using recorded information sources such as school records. JF - British Journal of Cancer AU - Cook, M B AU - Zhang, Y AU - Graubard, B I AU - Rubertone, M V AU - Erickson, R L AU - McGlynn, KA AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS/5005, 6120 Executive Boulevard, Rockville, MD 20892-7234, USA, cookmich@mail.nih.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 174 EP - 178 VL - 98 IS - 1 SN - 0007-0920, 0007-0920 KW - Physical Education Index; Risk Abstracts KW - Tumors KW - Exercise KW - Children KW - Sports KW - Cancer KW - Grading KW - Schools KW - Analysis KW - physical activity KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20620530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+testicular+germ-cell+tumours+in+relation+to+childhood+physical+activity&rft.au=Cook%2C+M+B%3BZhang%2C+Y%3BGraubard%2C+B+I%3BRubertone%2C+M+V%3BErickson%2C+R+L%3BMcGlynn%2C+KA&rft.aulast=Cook&rft.aufirst=M&rft.date=2008-01-15&rft.volume=98&rft.issue=1&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604109 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Grading; Exercise; Analysis; Tumors; Sports; Schools; Cancer; physical activity; Children DO - http://dx.doi.org/10.1038/sj.bjc.6604109 ER - TY - JOUR T1 - Genetic Deficiency of Chemokine Receptor CCR5 Is a Strong Risk Factor for Symptomatic West Nile Virus Infection; A Meta-Analysis of 4 Cohorts in the US Epidemic AN - 20252625; 8452192 AB - West Nile virus (WNV) causes disease in 20% of infected humans. We previously reported that homozygosity for CCR532, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, odds ratio [OR], 4.2 [95% confidence interval {CI}, 1.5-11.9] [P= 004 ]; for Illinois, OR, 3.1 [95% a, 0.9-11.2] [P = .06 ]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P = .0001 ]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States. JF - Journal of Infectious Diseases AU - Lim, J K AU - Louie, CY AU - Glaser, C AU - Jean, C AU - Johnson, B AU - Johnson, H AU - McDermott, D H AU - Murphy, P M AD - National Institutes of Health, 9000 Rockville Pike, Bldg. 10, Rm. 11N113, Bethesda, MD 20892, USA, pmm@nih.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 262 EP - 265 VL - 197 IS - 2 SN - 0022-1899, 0022-1899 KW - Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts; Immunology Abstracts KW - Epidemics KW - USA, Illinois KW - Receptors KW - Chemokine receptors KW - CCR5 protein KW - Infection KW - Cohorts KW - Risks KW - Disease transmission KW - USA, Colorado KW - Infectious diseases KW - Reviews KW - Risk factors KW - USA, Arizona KW - USA, California KW - West Nile virus KW - G 07880:Human Genetics KW - Q5 08501:General KW - F 06910:Microorganisms & Parasites KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20252625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Genetic+Deficiency+of+Chemokine+Receptor+CCR5+Is+a+Strong+Risk+Factor+for+Symptomatic+West+Nile+Virus+Infection%3B+A+Meta-Analysis+of+4+Cohorts+in+the+US+Epidemic&rft.au=Lim%2C+J+K%3BLouie%2C+CY%3BGlaser%2C+C%3BJean%2C+C%3BJohnson%2C+B%3BJohnson%2C+H%3BMcDermott%2C+D+H%3BMurphy%2C+P+M&rft.aulast=Lim&rft.aufirst=J&rft.date=2008-01-15&rft.volume=197&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F524691 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Epidemics; Infectious diseases; Receptors; Cohorts; Risks; Disease transmission; Risk factors; Reviews; Chemokine receptors; CCR5 protein; Infection; West Nile virus; USA, Colorado; USA, Illinois; USA, Arizona; USA, California DO - http://dx.doi.org/10.1086/524691 ER - TY - JOUR T1 - Antibiotic use and risk of non-Hodgkin's lymphoma: a population-based case-control study AN - 20003758; 8074888 AB - Antibiotic use in 759 non-Hodgkin's lymphoma (NHL) patients and 589 controls was compared. Neither total antibiotic use (odds ratio = 0.7, 95% confidence interval = 0.5-1.2), nor antibiotic use by site, was associated with total NHL, or NHL subtypes. There were no trends with frequency or age at first use (P trend = 0.23 and 0.26, respectively). JF - British Journal of Cancer AU - Anderson, LA AU - Gridley, G AU - Engels, E A AU - Morton, L M AU - Cerhan, J R AU - Cozen, W AU - Severson, R K AU - Davis, S AU - Hartge, P AU - Linet AD - Viral Epidemiology Branch, Room 7068, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA, anderles@mail.nih.gov Y1 - 2008/01/15/ PY - 2008 DA - 2008 Jan 15 SP - 161 EP - 164 VL - 98 IS - 1 SN - 0007-0920, 0007-0920 KW - Immunology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Antibiotics KW - Cancer KW - Non-Hodgkin's lymphoma KW - Lymphoma KW - Side effects KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20003758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Antibiotic+use+and+risk+of+non-Hodgkin%27s+lymphoma%3A+a+population-based+case-control+study&rft.au=Anderson%2C+LA%3BGridley%2C+G%3BEngels%2C+E+A%3BMorton%2C+L+M%3BCerhan%2C+J+R%3BCozen%2C+W%3BSeverson%2C+R+K%3BDavis%2C+S%3BHartge%2C+P%3BLinet&rft.aulast=Anderson&rft.aufirst=LA&rft.date=2008-01-15&rft.volume=98&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604127 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Lymphoma; Antibiotics; Side effects; Cancer; Age; Non-Hodgkin's lymphoma DO - http://dx.doi.org/10.1038/sj.bjc.6604127 ER - TY - JOUR T1 - Locus-specific and activity-independent gene repositioning during early tumorigenesis. AN - 70212110; 18195100 AB - The mammalian genome is highly organized within the cell nucleus. The nuclear position of many genes and genomic regions changes during physiological processes such as proliferation, differentiation, and disease. It is unclear whether disease-associated positioning changes occur specifically or are part of more global genome reorganization events. Here, we have analyzed the spatial position of a defined set of cancer-associated genes in an established mammary epithelial three-dimensional cell culture model of the early stages of breast cancer. We find that the genome is globally reorganized during normal and tumorigenic epithelial differentiation. Systematic mapping of changes in spatial positioning of cancer-associated genes reveals gene-specific positioning behavior and we identify several genes that are specifically repositioned during tumorigenesis. Alterations of spatial positioning patterns during differentiation and tumorigenesis were unrelated to gene activity. Our results demonstrate the existence of activity-independent genome repositioning events in the early stages of tumor formation. JF - The Journal of cell biology AU - Meaburn, Karen J AU - Misteli, Tom AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/01/14/ PY - 2008 DA - 2008 Jan 14 SP - 39 EP - 50 VL - 180 IS - 1 KW - Index Medicus KW - Humans KW - Cell Nucleolus -- ultrastructure KW - Breast -- cytology KW - Gene Expression KW - Gene Rearrangement KW - Cell Line, Tumor KW - Chromosome Mapping KW - Mutagenesis KW - Genomics KW - Breast Neoplasms -- genetics KW - Genes, Neoplasm KW - Breast Neoplasms -- pathology KW - Cell Differentiation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70212110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Locus-specific+and+activity-independent+gene+repositioning+during+early+tumorigenesis.&rft.au=Meaburn%2C+Karen+J%3BMisteli%2C+Tom&rft.aulast=Meaburn&rft.aufirst=Karen&rft.date=2008-01-14&rft.volume=180&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=1540-8140&rft_id=info:doi/10.1083%2Fjcb.200708204 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-08 N1 - Date created - 2008-01-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1990 Sep 15;50(18):6075-86 [1975513] Exp Cell Res. 2004 Aug 1;298(1):122-32 [15242767] Biochim Biophys Acta. 1994 Dec 30;1198(2-3):165-84 [7819273] J Cell Biol. 1996 Dec;135(5):1195-205 [8947544] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14711-6 [9843954] J Cell Biol. 1999 Jun 14;145(6):1119-31 [10366586] Mol Cell Biol. 1999 Oct;19(10):6845-57 [10490623] Exp Cell Res. 2004 Dec 10;301(2):266-79 [15530862] J Cell Sci. 2005 Mar 15;118(Pt 6):1321-30 [15741234] BMC Biol. 2004;2:12 [15176976] Histochem Cell Biol. 2005 Mar;123(3):229-38 [15827756] J Cell Sci. 2005 May 1;118(Pt 9):1811-20 [15827089] Semin Cancer Biol. 2005 Oct;15(5):342-52 [15963732] Nat Rev Cancer. 2005 Sep;5(9):675-88 [16148884] Exp Cell Res. 2005 Nov 15;311(1):14-26 [16202404] Cancer Genet Cytogenet. 2005 Nov;163(1):23-9 [16271952] J Cell Sci. 2006 Jan 1;119(Pt 1):132-40 [16371653] BMC Cell Biol. 2005;6:44 [16336643] J Proteome Res. 2006 Mar;5(3):599-610 [16512675] Breast Cancer Res Treat. 2006 Mar;96(2):177-86 [16319984] J Cell Physiol. 2006 Jul;208(1):141-8 [16607610] Proc Natl Acad Sci U S A. 2006 May 16;103(20):7688-93 [16682630] Curr Biol. 2000 Feb 10;10(3):149-52 [10679329] Oncogene. 2000 Dec 11;19(53):6102-14 [11156523] Nat Rev Cancer. 2004 Sep;4(9):677-87 [15343274] Science. 1988 Dec 23;242(4886):1687-91 [3201257] Curr Opin Cell Biol. 2006 Jun;18(3):307-16 [16687245] Genes Dev. 2006 Jun 1;20(11):1447-57 [16705039] Cancer Res. 2006 Jul 15;66(14):7095-102 [16849555] J Struct Biol. 2006 Sep;155(3):493-504 [16837212] Nat Cell Biol. 2006 Nov;8(11):1235-45 [17060907] Semin Cancer Biol. 2007 Feb;17(1):80-90 [17137790] Nat Rev Genet. 2007 Feb;8(2):104-15 [17230197] Nature. 2007 Jan 25;445(7126):379-781 [17251970] Cell. 2007 Feb 23;128(4):787-800 [17320514] PLoS One. 2007;2(2):e199 [17332847] Aging Cell. 2007 Apr;6(2):139-53 [17274801] J Cell Sci. 2007 May 1;120(Pt 9):1596-606 [17405811] Chromosoma. 2007 Jun;116(3):307-20 [17318634] Chromosoma. 2007 Jun;116(3):285-306 [17333233] Cytometry A. 2007 Jun;71(6):386-92 [17342774] Nature. 2007 May 24;447(7143):413-7 [17522674] Exp Cell Res. 2007 Aug 15;313(14):3066-75 [17524393] PLoS Biol. 2007 Aug;5(8):e192 [17622196] Curr Opin Genet Dev. 2007 Oct;17(5):435-42 [17905579] Hum Mol Genet. 2001 Feb 1;10(3):211-9 [11159939] EMBO J. 2001 Jun 1;20(11):2867-74 [11387219] Nat Immunol. 2001 Sep;2(9):848-54 [11526401] Nat Cell Biol. 2001 Sep;3(9):785-92 [11533657] Science. 2002 Apr 5;296(5565):158-62 [11935030] J Cell Biol. 2002 May 13;157(4):579-89 [11994314] Cell. 2002 Oct 4;111(1):29-40 [12372298] J Struct Biol. 2002 Aug;139(2):76-89 [12406690] Hum Genet. 2003 Feb;112(2):143-55 [12522555] Methods. 2003 Jul;30(3):256-68 [12798140] J Cell Biol. 2003 Sep 1;162(5):809-20 [12952935] Chromosome Res. 2003;11(5):513-25 [12971726] Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1257-62 [14739340] Genes Dev. 2004 May 15;18(10):1119-30 [15155579] Chromosoma. 2004 Jun;112(8):410-23 [15197559] Cytogenet Genome Res. 2004;105(2-4):292-301 [15237218] Genome Biol. 2004;5(7):R44 [15239829] Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9064-8 [1384042] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1083/jcb.200708204 ER - TY - JOUR T1 - Eye Movement Patterns for Novice Teen Drivers: Does 6 Months of Driving Experience Make a Difference? AN - 20497126; 8014288 AB - Attention to the road is essential to safe driving, but the development of appropriate eye glance scanning behaviors may require substantial driving experience. Novice teen drivers may focus almost exclusively on the road ahead rather than scanning the mirrors, and when performing secondary tasks, they may spend more time with eyes on the task than on the road. This paper examines the extent to which the scanning of novice teens improves with experience. For this study, 18 novice teen (younger than 17.5 years old) and 18 experienced adult drivers performed a set of in-vehicle tasks and a baseline driving segment on a test track, the teens within 4 weeks of licensure and then again 6 months later. This paper addresses the following questions: Did teen eye glance performance improve from initial assessment? Did teens and adults still differ after 6 months? Results for some tasks showed that rearview and left mirror-window (LM-W) glances improved for teens from initial testing to the 6-month follow-up and that some differences between teens and adults at initial testing were no longer significant at the 6-month followup, suggesting significant learning effects. The frequency of rearview and LM-W glances during secondary tasks improved among teens at the 6-month follow-up, but teens still had significantly fewer glances to mirrors than did adults when engaged in a secondary task. JF - Journal of the Transportation Research Board AU - Olsen, ECB AU - Lee, SE AU - Simons-Morton, B G AD - Room 7B05 National Institute of Child Health and Human Development, 6100 Executive Boulevard, Bethesda, MD 20892-7510, USA Y1 - 2008/01/14/ PY - 2008 DA - 2008 Jan 14 SP - 8 EP - 14 IS - 2009 KW - eye movement KW - Health & Safety Science Abstracts KW - Driving ability KW - Adolescents KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20497126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Transportation+Research+Board&rft.atitle=Eye+Movement+Patterns+for+Novice+Teen+Drivers%3A+Does+6+Months+of+Driving+Experience+Make+a+Difference%3F&rft.au=Olsen%2C+ECB%3BLee%2C+SE%3BSimons-Morton%2C+B+G&rft.aulast=Olsen&rft.aufirst=ECB&rft.date=2008-01-14&rft.volume=&rft.issue=2009&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Transportation+Research+Board&rft.issn=&rft_id=info:doi/10.3141%2F2009-02 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Driving ability; Adolescents DO - http://dx.doi.org/10.3141/2009-02 ER - TY - CPAPER T1 - Multi-Cellular Communication in Lymph Nodes T2 - 2008 Keystone Symposia on Leukocyte Trafficking (J4) AN - 40723334; 4762330 JF - 2008 Keystone Symposia on Leukocyte Trafficking (J4) AU - Germain, Ronald N Y1 - 2008/01/13/ PY - 2008 DA - 2008 Jan 13 KW - Lymph nodes KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40723334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Leukocyte+Trafficking+%28J4%29&rft.atitle=Multi-Cellular+Communication+in+Lymph+Nodes&rft.au=Germain%2C+Ronald+N&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2008-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Leukocyte+Trafficking+%28J4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=93 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemokine Receptors on Th17 Cells and Other CD4+ Effector/Memory T Cell Subsets in Humans. T2 - 2008 Keystone Symposia on Chemokines and Chemokine Receptors (J3) AN - 40720016; 4762394 JF - 2008 Keystone Symposia on Chemokines and Chemokine Receptors (J3) AU - Farber, Joshua M Y1 - 2008/01/13/ PY - 2008 DA - 2008 Jan 13 KW - Memory cells KW - Chemokine receptors KW - Lymphocytes T KW - Immunological memory KW - CD4 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28J3%29&rft.atitle=Chemokine+Receptors+on+Th17+Cells+and+Other+CD4%2B+Effector%2FMemory+T+Cell+Subsets+in+Humans.&rft.au=Farber%2C+Joshua+M&rft.aulast=Farber&rft.aufirst=Joshua&rft.date=2008-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28J3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=93 7&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Del-1 (Developmentally Regulated Endothelial Locus-1): A Novel Endogenous Anti-adhesive Protein that Blocks Inflammatory Cell Recruitment. T2 - 2008 Keystone Symposia on Leukocyte Trafficking (J4) AN - 40718681; 4762354 JF - 2008 Keystone Symposia on Leukocyte Trafficking (J4) AU - Choi, Eun Young Y1 - 2008/01/13/ PY - 2008 DA - 2008 Jan 13 KW - Recruitment KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40718681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Leukocyte+Trafficking+%28J4%29&rft.atitle=Del-1+%28Developmentally+Regulated+Endothelial+Locus-1%29%3A+A+Novel+Endogenous+Anti-adhesive+Protein+that+Blocks+Inflammatory+Cell+Recruitment.&rft.au=Choi%2C+Eun+Young&rft.aulast=Choi&rft.aufirst=Eun&rft.date=2008-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Leukocyte+Trafficking+%28J4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=93 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Foxa2, Dopamine Neurons, and Parkinson's Disease. T2 - 2008 Keystone Symposia on Forkhead Transcription Factor Networks in Development, Signaling, and Disease (A3) AN - 40718602; 4762234 JF - 2008 Keystone Symposia on Forkhead Transcription Factor Networks in Development, Signaling, and Disease (A3) AU - McKay, Ronald D Y1 - 2008/01/13/ PY - 2008 DA - 2008 Jan 13 KW - Parkinson's disease KW - Movement disorders KW - Neurodegenerative diseases KW - Neurons KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40718602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Forkhead+Transcription+Factor+Networks+in+Development%2C+Signaling%2C+and+Disease+%28A3%29&rft.atitle=Foxa2%2C+Dopamine+Neurons%2C+and+Parkinson%27s+Disease.&rft.au=McKay%2C+Ronald+D&rft.aulast=McKay&rft.aufirst=Ronald&rft.date=2008-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Forkhead+Transcription+Factor+Networks+in+Development%2C+Signaling%2C+and+Disease+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=95 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Modulation of Chemokine Receptor Signaling and Function T2 - 2008 Keystone Symposia on Chemokines and Chemokine Receptors (J3) AN - 40716815; 4762375 JF - 2008 Keystone Symposia on Chemokines and Chemokine Receptors (J3) AU - Kehrl, John H Y1 - 2008/01/13/ PY - 2008 DA - 2008 Jan 13 KW - Chemokine receptors KW - Intracellular signalling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40716815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28J3%29&rft.atitle=Intracellular+Modulation+of+Chemokine+Receptor+Signaling+and+Function&rft.au=Kehrl%2C+John+H&rft.aulast=Kehrl&rft.aufirst=John&rft.date=2008-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Chemokines+and+Chemokine+Receptors+%28J3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=93 7&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Live Cell Photoactivated Localization Microscopy (PALM) for the Spatio-Temporal Mapping of Single Molecule Diffusion in the Plasma Membrane T2 - 2008 Keystone Symposia on Molecular Basis for Biological Membrane Organization (A2) AN - 40721538; 4762210 JF - 2008 Keystone Symposia on Molecular Basis for Biological Membrane Organization (A2) AU - Manley, Suliana Y1 - 2008/01/12/ PY - 2008 DA - 2008 Jan 12 KW - Mapping KW - Plasma membranes KW - Diffusion KW - Microscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40721538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Molecular+Basis+for+Biological+Membrane+Organization+%28A2%29&rft.atitle=Live+Cell+Photoactivated+Localization+Microscopy+%28PALM%29+for+the+Spatio-Temporal+Mapping+of+Single+Molecule+Diffusion+in+the+Plasma+Membrane&rft.au=Manley%2C+Suliana&rft.aulast=Manley&rft.aufirst=Suliana&rft.date=2008-01-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Molecular+Basis+for+Biological+Membrane+Organization+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=92 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein-Lipid Interplay in Membrane Fusion T2 - 2008 Keystone Symposia on Molecular Basis for Biological Membrane Organization (A2) AN - 40720485; 4762202 JF - 2008 Keystone Symposia on Molecular Basis for Biological Membrane Organization (A2) AU - Chernomordik, Leonid V Y1 - 2008/01/12/ PY - 2008 DA - 2008 Jan 12 KW - Membrane fusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Molecular+Basis+for+Biological+Membrane+Organization+%28A2%29&rft.atitle=Protein-Lipid+Interplay+in+Membrane+Fusion&rft.au=Chernomordik%2C+Leonid+V&rft.aulast=Chernomordik&rft.aufirst=Leonid&rft.date=2008-01-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Molecular+Basis+for+Biological+Membrane+Organization+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=92 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Analysis of Dynamin Family Members Offers Insight into Membrane Fission T2 - 2008 Keystone Symposia on Molecular Basis for Biological Membrane Organization (A2) AN - 40719057; 4762217 JF - 2008 Keystone Symposia on Molecular Basis for Biological Membrane Organization (A2) AU - Mears, Jason A Y1 - 2008/01/12/ PY - 2008 DA - 2008 Jan 12 KW - Structural analysis KW - Membranes KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40719057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Molecular+Basis+for+Biological+Membrane+Organization+%28A2%29&rft.atitle=Structural+Analysis+of+Dynamin+Family+Members+Offers+Insight+into+Membrane+Fission&rft.au=Mears%2C+Jason+A&rft.aulast=Mears&rft.aufirst=Jason&rft.date=2008-01-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Molecular+Basis+for+Biological+Membrane+Organization+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=92 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Role of receptor polymorphism and glycosylation in syncytium induction and host range variation of ecotropic mouse gammaretroviruses. AN - 70315563; 18186934 AB - We previously identified unusual variants of Moloney and Friend ecotropic mouse gammaretroviruses that have altered host range and are cytopathic in cells of the wild mouse species Mus dunni. Cytopathicity was attributed to different amino acid substitutions at the same critical env residue involved in receptor interaction: S82F in the Moloney variant Spl574, and S84A in the Friend mouse leukemia virus F-S MLV. Because M. dunni cells carry a variant CAT-1 cell surface virus receptor (dCAT-1), we examined the role of this receptor variant in cytopathicity and host range. We expressed dCAT-1 or mCAT-1 of NIH 3T3 origin in cells that are not normally infectible with ecotropic MLVs and evaluated the transfectants for susceptibility to virus infection and to virus-induced syncytium formation. The dCAT-1 transfectants, but not the mCAT-1 transfectants, were susceptible to virus-induced cytopathicity, and this cytopathic response was accompanied by the accumulation of unintegrated viral DNA. The dCAT-1 transfectants, however, did not also reproduce the relative resistance of M. dunni cells to Moloney MLV, and the mCAT-1 transfectants did not show the relative resistance of NIH 3T3 cells to Spl574. Western analysis, use of glycosylation inhibitors and mutagenesis to remove receptor glycosylation sites identified a possible role for cell-specific glycosylation in the modulation of virus entry. Virus entry and virus-induced syncytium formation using the CAT-1 receptor are mediated by a small number of critical amino acid residues in receptor and virus Env. Virus entry is modulated by glycosylation of cellular proteins, and this effect is cell and virus-specific. JF - Retrovirology AU - Yan, Yuhe AU - Jung, Yong T AU - Wu, Tiyun AU - Kozak, Christine A AD - Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892-0460, USA. yyan@niaid.nih.gov Y1 - 2008/01/10/ PY - 2008 DA - 2008 Jan 10 SP - 2 VL - 5 KW - Cationic Amino Acid Transporter 1 KW - 0 KW - Slc7a1 protein, mouse KW - Index Medicus KW - Retroviridae Infections -- virology KW - Animals KW - Tumor Virus Infections -- virology KW - Transfection KW - Mice KW - Leukemia, Experimental -- virology KW - Cytopathogenic Effect, Viral KW - Virus Internalization KW - Glycosylation KW - NIH 3T3 Cells KW - Cell Line KW - Animals, Wild KW - Moloney murine leukemia virus -- pathogenicity KW - Cationic Amino Acid Transporter 1 -- genetics KW - Polymorphism, Genetic KW - Giant Cells -- physiology KW - Cationic Amino Acid Transporter 1 -- metabolism KW - Friend murine leukemia virus -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70315563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Retrovirology&rft.atitle=Role+of+receptor+polymorphism+and+glycosylation+in+syncytium+induction+and+host+range+variation+of+ecotropic+mouse+gammaretroviruses.&rft.au=Yan%2C+Yuhe%3BJung%2C+Yong+T%3BWu%2C+Tiyun%3BKozak%2C+Christine+A&rft.aulast=Yan&rft.aufirst=Yuhe&rft.date=2008-01-10&rft.volume=5&rft.issue=&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Retrovirology&rft.issn=1742-4690&rft_id=info:doi/10.1186%2F1742-4690-5-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2001 Oct;75(20):9741-52 [11559807] Virology. 2002 Nov 25;303(2):338-44 [12490395] J Virol. 2003 Jan;77(2):963-9 [12502812] J Virol. 2003 May;77(9):5065-72 [12692209] Curr Top Microbiol Immunol. 2003;281:29-106 [12932075] J Virol. 2004 Nov;78(21):12071-4 [15479849] J Virol. 2004 Nov;78(22):12189-97 [15507605] J Mol Biol. 1967 Jun 14;26(2):365-9 [4291934] Virology. 1970 Dec;42(4):1136-9 [4099080] Virology. 1975 May;65(1):128-34 [167514] J Virol. 1984 Nov;52(2):695-8 [6092693] Rev Infect Dis. 1988 Mar-Apr;10(2):399-405 [2836939] J Virol. 1991 Nov;65(11):5975-82 [1717711] J Virol. 1992 Jan;66(1):78-84 [1370096] J Virol. 1992 Dec;66(12):7262-9 [1433518] J Virol. 1993 Mar;67(3):1310-4 [8382297] J Virol. 1993 Apr;67(4):2091-6 [8445722] J Virol. 1993 Jul;67(7):4056-61 [8510216] J Biol Chem. 1993 Aug 5;268(22):16316-20 [8393858] J Virol. 1994 Feb;68(2):626-31 [8289366] J Virol. 1994 Nov;68(11):7516-24 [7933135] J Virol. 1996 Oct;70(10):6884-91 [8794331] Virology. 1997 Mar 3;229(1):49-56 [9123877] Science. 1997 Sep 12;277(5332):1662-6 [9287219] J Virol. 1999 May;73(5):3758-63 [10196270] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1742-4690-5-2 ER - TY - JOUR T1 - Effects of chronic swim stress on EtOH-related behaviors in C57BL/6J, DBA/2J and BALB/cByJ mice. AN - 70106012; 17822784 AB - There is a strong clinical relationship between stress and stress-related disorders and the incidence of alcohol abuse and alcoholism, and this relationship appears to be partly genetic in origin. There are marked strain differences in ethanol (EtOH)-related behaviors and reactivity to stress, but little investigation of the interaction between the two. The present study assessed the effects of chronic exposure to swim stress on EtOH-related behavior in three common inbred strains of mice, C57BL/6J, DBA/2J and BALB/cByJ. After establishing baseline (10%) EtOH self-administration in a two-bottle free choice test, mice were exposed to daily swim stress for 14 consecutive days and EtOH consumption was measured as a percent of baseline both during stress and for 10 days afterwards. A separate experiment examined the effects of 14 days of swim stress on sensitivity to the sedative/hypnotic effects of an acute injection of 4g/kg EtOH. Results showed that stress produced a significant decrease in EtOH consumption, relative to pre-stress baseline, in DBA/2J and BALB/cByJ, but not C57BL/6J mice. By contrast, stress increased sensitivity to the sedative/hypnotic effects of EtOH in all three strains. These findings demonstrate that chronic swim stress produces reductions in EtOH self-administration in a strain-dependent manner, and that these effects may be restricted to strains with a pre-existing aversion to EtOH. Present data also demonstrates a dissociation between effects of this stressor on EtOH self-administration and sensitivity to EtOH's sedative/hypnotic effects. In conclusion, strain differences, that are likely in large part genetic in nature, modify the effects of this stressor on EtOH's effects in a behavior-specific manner. JF - Behavioural brain research AU - Boyce-Rustay, Janel M AU - Janos, Alicia L AU - Holmes, Andrew AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA. janel.boyce-rustay@abbott.com Y1 - 2008/01/10/ PY - 2008 DA - 2008 Jan 10 SP - 133 EP - 137 VL - 186 IS - 1 SN - 0166-4328, 0166-4328 KW - Hypnotics and Sedatives KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Disease Models, Animal KW - Self Administration -- psychology KW - Mice KW - Mice, Inbred BALB C KW - Mice, Inbred DBA KW - Swimming -- psychology KW - Swimming -- physiology KW - Adaptation, Psychological KW - Mice, Inbred C57BL KW - Adaptation, Physiological KW - Species Specificity KW - Male KW - Ethanol -- pharmacology KW - Stress, Psychological -- physiopathology KW - Hypnotics and Sedatives -- administration & dosage KW - Ethanol -- administration & dosage KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- physiopathology KW - Alcoholism -- physiopathology KW - Alcoholism -- psychology KW - Alcoholism -- complications KW - Hypnotics and Sedatives -- pharmacology KW - Stress, Psychological -- psychology KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70106012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Effects+of+chronic+swim+stress+on+EtOH-related+behaviors+in+C57BL%2F6J%2C+DBA%2F2J+and+BALB%2FcByJ+mice.&rft.au=Boyce-Rustay%2C+Janel+M%3BJanos%2C+Alicia+L%3BHolmes%2C+Andrew&rft.aulast=Boyce-Rustay&rft.aufirst=Janel&rft.date=2008-01-10&rft.volume=186&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=01664328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-12 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Physiol Behav. 1987;40(3):377-82 [3659155] J Abnorm Psychol. 1987 Aug;96(3):242-53 [3680764] J Abnorm Psychol. 1990 Feb;99(1):79-85 [2307770] Pharmacol Biochem Behav. 1990 Feb;35(2):469-72 [2320658] Psychol Bull. 1990 Nov;108(3):383-402 [2270234] Br J Addict. 1991 Feb;86(2):157-69 [2021699] Alcohol Clin Exp Res. 1991 Jun;15(3):438-59 [1898494] Behav Neurosci. 1992 Aug;106(4):682-9 [1323971] Pharmacol Biochem Behav. 1992 Sep;43(1):285-90 [1409813] Neurosci Lett. 1993 May 14;154(1-2):175-8 [8361637] Psychopharmacology (Berl). 1993;112(4):503-10 [7871064] J Pharmacol Exp Ther. 1995 Nov;275(2):790-7 [7473168] Alcohol Clin Exp Res. 1996 Apr;20(2):313-9 [8730223] Behav Neurosci. 1996 Apr;110(2):360-7 [8731063] Psychopharmacology (Berl). 1999 Nov;147(2):182-9 [10591886] Exp Clin Psychopharmacol. 1999 Nov;7(4):318-23 [10609966] J Neurosci. 2000 May 15;20(10):RC75 [10783399] Neurochem Res. 2000 Dec;25(12):1547-52 [11152383] Pharmacol Biochem Behav. 2001 Feb;68(2):263-72 [11267631] Physiol Behav. 2001 Jun;73(3):301-11 [11438355] Behav Brain Res. 2001 Nov 1;125(1-2):141-9 [11682105] Arch Gen Psychiatry. 2001 Nov;58(11):1005-14 [11695946] Behav Pharmacol. 2001 Sep;12(5):335-42 [11710748] Biol Psychiatry. 2002 Apr 15;51(8):652-8 [11955465] Science. 2002 May 3;296(5569):931-3 [11988580] Pharmacol Ther. 2002 Apr-May;94(1-2):137-56 [12191599] Alcohol Clin Exp Res. 2002 Aug;26(8):1171-80 [12198391] Neuropsychopharmacology. 2002 Sep;27(3):442-52 [12225701] Drug Alcohol Depend. 2002 Dec 1;68(3):299-307 [12393224] J Neurosci. 2002 Dec 1;22(23):10487-93 [12451148] Biol Psychiatry. 2003 Feb 15;53(4):292-303 [12586448] Alcohol Clin Exp Res. 2003 Feb;27(2):232-43 [12605072] Brain Res. 1997 Apr 11;753(2):318-21 [9125418] Alcohol Clin Exp Res. 1998 May;22(3):585-97 [9622436] Q J Stud Alcohol. 1956 Jun;17(2):296-305 [13336262] Psychopharmacology (Berl). 2004 Nov;176(3-4):386-97 [15138758] Alcohol Clin Exp Res. 2004 Oct;28(10):1449-58 [15597076] Neurosci Biobehav Rev. 2005 Jan;28(8):785-802 [15642621] Psychopharmacology (Berl). 2005 Mar;178(2-3):125-32 [15719228] Alcohol. 2004 Oct-Nov;34(2-3):177-85 [15902911] Addiction. 2005 Jun;100(6):787-96 [15918809] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] Alcohol Clin Exp Res. 2005 Jul;29(7):1133-8 [16046867] Alcohol Alcohol. 2005 Sep-Oct;40(5):453-60 [15972275] Nat Rev Drug Discov. 2005 Sep;4(9):775-90 [16138108] Drug Alcohol Depend. 2005 Oct 1;80(1):105-16 [16157233] J Neurosci. 2006 May 24;26(21):5733-8 [16723530] Psychopharmacology (Berl). 2006 Sep;187(4):455-66 [16835771] Neuropsychopharmacology. 2006 Oct;31(10):2255-63 [16554744] Neurosci Biobehav Rev. 2007;31(1):3-17 [16950513] Physiol Behav. 2007 May 16;91(1):77-86 [17363014] J Stud Alcohol. 1996 Nov;57(6):619-26 [8913993] J Neurosci. 2003 Mar 15;23(6):2453-8 [12657705] Alcohol Clin Exp Res. 2003 Jul;27(7):1048-54 [12878910] J Neurosci Res. 2003 Aug 15;73(4):573-80 [12898542] Alcohol Clin Exp Res. 2004 Mar;28(3):385-93 [15084895] Neuropsychopharmacology. 2004 Jun;29(6):1156-65 [15100697] Physiol Behav. 2004 Apr;81(2):339-58 [15159175] J Comp Physiol Psychol. 1979 Apr;93(2):242-6 [457948] Life Sci. 1986 Jan 20;38(3):273-9 [3941595] Pharmacol Biochem Behav. 1986 Nov;25(5):1083-7 [3786361] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells AN - 19466354; 8040006 AB - In the mammalian brain, neurogenesis continues only in few regions of the forebrain. The molecular signals governing neurogenesis in these unique neurogenic niches, however, are still ill defined. Here, we show that bone morphogenic protein (BMP)-mediated signaling is active in adult neural stem cells and is crucial to initiate the neurogenic lineage in the adult mouse subependymal zone. Conditional deletion of Smad4 in adult neural stem cells severely impairs neurogenesis, and this is phenocopied by infusion of Noggin, an extracellular antagonist of BMP. Smad4 deletion in stem, but not progenitor cells, as well as Noggin infusion lead to an increased number of Olig2-expressing progeny that migrate to the corpus callosum and differentiate into oligodendrocytes. Transplantation experiments further verified the cell-autonomous nature of this phenotype. Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis. JF - Journal of Neuroscience AU - Colak, Dilek AU - Mori, Tetsuji AU - Brill, Monika S AU - Pfeifer, Alexander AU - Falk, Sven AU - Deng, Chuxia AU - Monteiro, Rui AU - Mummery, Christine AU - Sommer, Lukas AU - Goetz, Magdalena AD - Helmhotz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, 85764 Neuherberg/Munich, Germany, Institute for Pharmacology and Toxicology, University of Bonn, 53113 Bonn, Germany, Institute of Anatomy, University of Zurich, CH-8057 Zurich, Switzerland, Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, Developmental Biology, Hubrecht Institute, 3584CT Utrecht, Netherlands, and Physiological Genomics, University of Munich, 80336 Munich, Germany Y1 - 2008/01/09/ PY - 2008 DA - 2008 Jan 09 SP - 434 EP - 446 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 28 IS - 2 SN - 0270-6474, 0270-6474 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Transplantation KW - Oligodendrocytes KW - Brain KW - Corpus callosum KW - Noggin protein KW - subependymal zone KW - Smad4 protein KW - Forebrain KW - Stem cells KW - Bone morphogenetic proteins KW - Neurogenesis KW - Progeny KW - Cell migration KW - Neural stem cells KW - Signal transduction KW - N3 11007:Neurobiology KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Adult+Neurogenesis+Requires+Smad4-Mediated+Bone+Morphogenic+Protein+Signaling+in+Stem+Cells&rft.au=Colak%2C+Dilek%3BMori%2C+Tetsuji%3BBrill%2C+Monika+S%3BPfeifer%2C+Alexander%3BFalk%2C+Sven%3BDeng%2C+Chuxia%3BMonteiro%2C+Rui%3BMummery%2C+Christine%3BSommer%2C+Lukas%3BGoetz%2C+Magdalena&rft.aulast=Colak&rft.aufirst=Dilek&rft.date=2008-01-09&rft.volume=28&rft.issue=2&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transplantation; Oligodendrocytes; Brain; Noggin protein; Corpus callosum; subependymal zone; Smad4 protein; Forebrain; Neurogenesis; Bone morphogenetic proteins; Stem cells; Progeny; Cell migration; Neural stem cells; Signal transduction ER - TY - JOUR T1 - Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. AN - 70148330; 17869571 AB - The development of automated flow cytometric (FCM) methods for evaluating micronucleus (MN) frequencies in erythrocytes has great potential for improving the sensitivity, reproducibility, and throughput of the traditional in vivo rodent MN assay that uses microscopy-based methods for data collection. Although some validation studies of the FCM evaluation methods have been performed, a comprehensive comparison of these two data collection methods under routine testing conditions with a variety of compounds in multiple species has not been conducted. Therefore, to determine if FCM evaluation of MN frequencies in rodents was an acceptable alternative to traditional manual scoring methods in our laboratory, we conducted a comparative evaluation of MN-reticulocyte (MN-RET) frequencies determined by FCM- and microscopy-based scoring of peripheral blood and bone marrow samples from B6C3F1 mice and Fisher 344 rats. Four known inducers of MN (cyclophosphamide, ethyl methanesulfonate, vincristine sulfate, acrylamide) were assayed in bone marrow and peripheral blood of both mice and rats. In addition, MN-RET frequencies were measured in bone marrow (microscopy) and peripheral blood (FCM) of mice treated with five nongenotoxic chemicals (S-adenosylmethionine chloride, cefuroxime, diphenolic acid, 3-amino-6-methylphenol, pentabromodiphenyl oxide). No significant differences were observed between results obtained by the two methods in either species. These results support the use of FCM for determining MN-RET frequency in rodents after chemical exposure. JF - Mutation research AU - Witt, Kristine L AU - Livanos, Elizabeth AU - Kissling, Grace E AU - Torous, Dorothea K AU - Caspary, William AU - Tice, Raymond R AU - Recio, Leslie AD - Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. witt@niehs.nih.gov Y1 - 2008/01/08/ PY - 2008 DA - 2008 Jan 08 SP - 101 EP - 113 VL - 649 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Vincristine KW - 5J49Q6B70F KW - Cyclophosphamide KW - 8N3DW7272P KW - Cefuroxime KW - O1R9FJ93ED KW - Index Medicus KW - Rats KW - Cefuroxime -- toxicity KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Micronucleus Tests KW - Mice KW - Cyclophosphamide -- toxicity KW - Cefuroxime -- pharmacology KW - Vincristine -- toxicity KW - Male KW - Reticulocytes -- drug effects KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Reticulocytes -- metabolism KW - Reticulocytes -- cytology KW - Microscopy, Fluorescence -- methods KW - Flow Cytometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70148330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Comparison+of+flow+cytometry-+and+microscopy-based+methods+for+measuring+micronucleated+reticulocyte+frequencies+in+rodents+treated+with+nongenotoxic+and+genotoxic+chemicals.&rft.au=Witt%2C+Kristine+L%3BLivanos%2C+Elizabeth%3BKissling%2C+Grace+E%3BTorous%2C+Dorothea+K%3BCaspary%2C+William%3BTice%2C+Raymond+R%3BRecio%2C+Leslie&rft.aulast=Witt&rft.aufirst=Kristine&rft.date=2008-01-08&rft.volume=649&rft.issue=1-2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-30 N1 - Date created - 2007-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Mol Mutagen. 2000;36(3):163-94 [11044899] Toxicol Sci. 2006 Nov;94(1):83-91 [16888078] Toxicol Sci. 2003 Oct;75(2):260-70 [12883088] Mutat Res. 1997 Feb 28;389(1):3-122 [9062586] Mutat Res. 1995 Jan;341(3):151-60 [7529356] Toxicol Sci. 2006 Nov;94(1):92-107 [16888079] Biochimie. 2006 Nov;88(11):1515-31 [16919864] Mutat Res. 2007 Jan 10;626(1-2):26-33 [16978914] Mutat Res. 2007 Feb 3;627(1):5-9 [17137830] Mutat Res. 2007 Feb 3;627(1):10-30 [17157053] Mutagenesis. 2007 Mar;22(2):129-34 [17284774] Carcinogenesis. 2007 Mar;28(3):625-31 [16973674] Mutat Res. 1994 Jun;312(3):293-304 [7514741] Mutat Res. 2000 Jan 24;464(2):195-200 [10648906] Environ Mol Mutagen. 2000;35(3):234-52 [10737958] Mutat Res. 2000 Aug;463(2):111-72 [10913908] Mutat Res. 1983 Jun;120(4):241-7 [6855792] Environ Mol Mutagen. 1998;31(4):340-4 [9654243] Mutat Res. 1984 Jul;127(2):169-74 [6749161] Mutat Res. 1988 Jan;204(1):3-15 [3277048] Basic Life Sci. 1988;43:11-21 [3284518] Fundam Appl Toxicol. 1990 Apr;14(3):513-22 [2111256] Mutat Res. 1990 Jun-Aug;234(3-4):257-61 [2366790] Mutat Res. 1990 Dec;245(4):245-9 [1702516] Environ Mol Mutagen. 1991;18(4):277-91 [1748091] Mutat Res. 1992 Feb-Mar;278(2-3):209-13 [1372708] Environ Mol Mutagen. 1993;21(2):160-79 [8444144] Environ Mol Mutagen. 1998;32(1):84-100 [9707102] Environ Mol Mutagen. 1999;33(1):65-74 [10037325] Environ Mol Mutagen. 2004;44(5):427-35 [15517570] Environ Mol Mutagen. 2005;45(1):44-55 [15605355] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):258-70 [15688363] Environ Health Perspect. 2005 May;113(5):517-20 [15866756] Trends Genet. 2006 Jan;22(1):46-55 [16257470] Mutagenesis. 2006 Jan;21(1):11-3 [16188876] Environ Mol Mutagen. 2006 Jun;47(5):362-90 [16649190] Toxicol Sci. 2003 Aug;74(2):309-14 [12773756] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - IL-10 Inhibits Cysteinyl Leukotrienes Induced Activation of Human Monocytes and Monocyte-Derived Dendritic Cells. T2 - 2008 Keystone Symposia on Eicosanoids and Other Mediators of Chronic Inflammation (A1) AN - 40723166; 4762258 JF - 2008 Keystone Symposia on Eicosanoids and Other Mediators of Chronic Inflammation (A1) AU - Woszczek, Grzegorz Y1 - 2008/01/07/ PY - 2008 DA - 2008 Jan 07 KW - Monocytes KW - Interleukin 10 KW - Dendritic cells KW - Leukotrienes KW - Cell activation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40723166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Eicosanoids+and+Other+Mediators+of+Chronic+Inflammation+%28A1%29&rft.atitle=IL-10+Inhibits+Cysteinyl+Leukotrienes+Induced+Activation+of+Human+Monocytes+and+Monocyte-Derived+Dendritic+Cells.&rft.au=Woszczek%2C+Grzegorz&rft.aulast=Woszczek&rft.aufirst=Grzegorz&rft.date=2008-01-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Eicosanoids+and+Other+Mediators+of+Chronic+Inflammation+%28A1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=93 9&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualizing Transient Low-Population Intermediates by Paramagnetic Relaxation Enhancement T2 - 2008 Keystone Symposia on Frontiers of Structural Biology (J1) AN - 40720465; 4762151 JF - 2008 Keystone Symposia on Frontiers of Structural Biology (J1) AU - Tang, Chun Y1 - 2008/01/06/ PY - 2008 DA - 2008 Jan 06 KW - Macromolecules KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40720465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Keystone+Symposia+on+Frontiers+of+Structural+Biology+%28J1%29&rft.atitle=Visualizing+Transient+Low-Population+Intermediates+by+Paramagnetic+Relaxation+Enhancement&rft.au=Tang%2C+Chun&rft.aulast=Tang&rft.aufirst=Chun&rft.date=2008-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Keystone+Symposia+on+Frontiers+of+Structural+Biology+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=90 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Matrix Metalloproteinase-activated Anthrax Lethal Toxin Demonstrates High Potency in Targeting Tumor Vasculature AN - 20842388; 7935255 AB - Anthrax lethal toxin (LT), a virulence factor secreted by Bacillus anthracis, is selectively toxic to human melanomas with the BRAF V600E activating mutation because of its proteolytic activities toward the mitogen-activated protein kinase kinases (MEKs). To develop LT variants with lower in vivo toxicity and high tumor specificity, and therefore greater potential for clinical use, we generated a mutated LT that requires activation by matrix metalloproteinases (MMPs). This engineered toxin was less toxic than wild-type LT to mice because of the limited expression of MMPs by normal cells. Moreover, the systemically administered toxin produced greater anti-tumor effects than wild-type LT toward human xenografted tumors. This was shown to result from its greater bioavailability, a consequence of the limited uptake and clearance of the modified toxin by normal cells. Furthermore, the MMP-activated LT had very potent anti-tumor activity not only to human melanomas containing the BRAF mutation but also to other tumor types, including lung and colon carcinomas regardless of their BRAF status. Tumor histology and in vivo angiogenesis assays showed that this anti-tumor activity is due largely to the indirect targeting of tumor vasculature and angiogenic processes. Thus, even tumors genetically deficient in anthrax toxin receptors were still susceptible to the toxin therapy in vivo. Moreover, the modified toxin also displayed lower immunogenicity compared with the wild-type toxin. All these properties suggest that this MMP-activated anti-tumor toxin has potential for use in cancer therapy. JF - Journal of Biological Chemistry AU - Liu, Shihui AU - Wang, Hailun AU - Currie, Brooke M AU - Molinolo, Alfredo AU - Leung, Howard J AU - Moayeri, Mahtab AU - Basile, John R AU - Alfano, Randall W AU - Gutkind, JSilvio AU - Frankel, Arthur E AU - Bugge, Thomas H AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892, Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, and Cancer Research Institute of Scott & White Memorial Hospital, Temple, Texas 76502 Y1 - 2008/01/04/ PY - 2008 DA - 2008 Jan 04 SP - 529 EP - 540 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 1 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - Anthrax lethal toxin KW - MAP kinase KW - virulence factors KW - Lung carcinoma KW - Angiogenesis KW - Matrix metalloproteinase KW - Toxicity KW - Tumors KW - Bacillus anthracis KW - Antitumor agents KW - Cancer KW - Melanoma KW - Colon KW - Immunogenicity KW - Lung KW - Anthrax KW - Mutation KW - X 24370:Natural Toxins KW - W 30915:Pharmaceuticals & Vaccines KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20842388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Matrix+Metalloproteinase-activated+Anthrax+Lethal+Toxin+Demonstrates+High+Potency+in+Targeting+Tumor+Vasculature&rft.au=Liu%2C+Shihui%3BWang%2C+Hailun%3BCurrie%2C+Brooke+M%3BMolinolo%2C+Alfredo%3BLeung%2C+Howard+J%3BMoayeri%2C+Mahtab%3BBasile%2C+John+R%3BAlfano%2C+Randall+W%3BGutkind%2C+JSilvio%3BFrankel%2C+Arthur+E%3BBugge%2C+Thomas+H%3BLeppla%2C+Stephen+H&rft.aulast=Liu&rft.aufirst=Shihui&rft.date=2008-01-04&rft.volume=283&rft.issue=1&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Proteolysis; Anthrax lethal toxin; MAP kinase; virulence factors; Lung carcinoma; Angiogenesis; Matrix metalloproteinase; Tumors; Toxicity; Antitumor agents; Cancer; Melanoma; Colon; Lung; Immunogenicity; Anthrax; Mutation; Bacillus anthracis ER - TY - JOUR T1 - A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population. AN - 70283311; 18171470 AB - Hepatitis B virus (HBV) infection is a significant public health problem that may lead to chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). Approximately 30% of the world's population has been infected with HBV and approximately 350 million (5-6%) are persistent carriers. More than 120 million Chinese are infected with HBV. The role of host genetic factors and their interactions with environmental factors leading to chronic HBV infection and its complications are not well understood. We believe that a better understanding of these factors and interactions will lead to more effective diagnostic and therapeutic options. This is a population-based, case-control study protocol to enroll 2200 Han Chinese from medical centers in northern and western China. Adult subjects in the following groups are being enrolled: healthy donors (n = 200), HBV infected persons achieving virus clearance (n = 400), asymptomatic HBV persistent carriers (n = 400), chronic hepatitis B cases (n = 400), decompensated liver cirrhosis with HBV infection cases (n = 400), and hepatocellular carcinoma with HBV infection cases (n = 400). In addition, for haplotype inference and quality control of sample handling and genotyping results, children of 1000 cases will be asked to provide a buccal sample for DNA extraction. With the exception of adult patients presenting with liver cirrhosis or HCC, all other cases and controls will be 40 years or older at enrollment. A questionnaire is being administered to capture dietary and environmental risk factors. Both candidate-gene and genome-wide association approaches will be used to assess the role of single genetic factors and higher order interactions with other genetic or environmental factors in HBV diseases. This study is designed and powered to detect single gene effects as well as gene-gene and environmental-gene interactions. The identification of allelic polymorphisms in genes involved in the pathway leading to chronic viral infection, liver cirrhosis and, ultimately, hepatocellular carcinoma would provide insights to those factors leading to HBV replication, liver inflammation, fibrosis, and the carcinogenic process. An understanding of the contribution of host genetic factors and their interactions may inform public health policy, improve diagnostics and clinical management, and provide targets for drug development. JF - BMC infectious diseases AU - Zeng, Zheng AU - Guan, Li AU - An, Ping AU - Sun, Shan AU - O'Brien, Stephen J AU - Winkler, Cheryl A AU - HBV study consortium AD - SAIC/Laboratory of Genomic Diversity, National Cancer Institute-Frederick, National Institutes of Health, Frederick, USA. zeng@bjmu.edu.cn ; HBV study consortium Y1 - 2008/01/02/ PY - 2008 DA - 2008 Jan 02 SP - 1 VL - 8 KW - Hepatitis Antibodies KW - 0 KW - Hepatitis B Antigens KW - Index Medicus KW - Hepatitis B Antigens -- blood KW - Polymorphism, Genetic KW - Humans KW - Hepatitis B, Chronic -- genetics KW - Liver Function Tests KW - Liver Cirrhosis -- genetics KW - Research Design KW - Host-Pathogen Interactions KW - Carrier State -- virology KW - Hepatitis Antibodies -- blood KW - Risk Factors KW - Carcinoma, Hepatocellular -- genetics KW - Surveys and Questionnaires KW - Case-Control Studies KW - Asian Continental Ancestry Group -- genetics KW - Hepatitis B -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70283311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+infectious+diseases&rft.atitle=A+population-based+study+to+investigate+host+genetic+factors+associated+with+hepatitis+B+infection+and+pathogenesis+in+the+Chinese+population.&rft.au=Zeng%2C+Zheng%3BGuan%2C+Li%3BAn%2C+Ping%3BSun%2C+Shan%3BO%27Brien%2C+Stephen+J%3BWinkler%2C+Cheryl+A%3BHBV+study+consortium&rft.aulast=Zeng&rft.aufirst=Zheng&rft.date=2008-01-02&rft.volume=8&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=BMC+infectious+diseases&rft.issn=1471-2334&rft_id=info:doi/10.1186%2F1471-2334-8-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-06 N1 - Date created - 2008-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: QJM. 1998 Jan;91(1):13-8 [9519208] Cancer Res. 1989 May 1;49(9):2506-9 [2539905] Exp Clin Immunogenet. 1998;15(3):130-3 [9813410] J Infect Dis. 1999 Mar;179(3):721-4 [9952386] Hepatology. 1999 Mar;29(3):883-8 [10051493] Hepatology. 1999 Mar;29(3):971-5 [10051505] J Infect Dis. 1999 Apr;179(4):1004-6 [10068598] Hepatology. 1999 Apr;29(4):1248-51 [10094971] Hepatology. 1999 Aug;30(2):379-83 [10421643] J Natl Cancer Inst. 2005 Feb 16;97(4):265-72 [15713961] J Hepatol. 2005 Apr;42(4):505-10 [15763337] Lancet. 1990 Aug 11;336(8711):325-9 [1697396] Nature. 1991 Apr 4;350(6317):427-8 [1849234] N Engl J Med. 1991 Jun 13;324(24):1705-9 [2034247] Lancet. 1992 Apr 18;339(8799):943-6 [1348796] Br J Cancer. 1993 Jun;67(6):1395-7 [8390289] Gastroenterology. 1993 Oct;105(4):1173-8 [8405863] J Clin Invest. 1994 Feb;93(2):550-5 [8113393] Cancer Epidemiol Biomarkers Prev. 1994 Jan-Feb;3(1):3-10 [8118382] Science. 1994 Sep 30;265(5181):2037-48 [8091226] Lancet. 1994 Oct 29;344(8931):1194-5 [7934542] Ann Intern Med. 1995 Feb 15;122(4):241-8 [7825758] N Engl J Med. 1995 Apr 20;332(16):1065-9 [7898524] Liver. 1995 Aug;15(4):202-8 [8544643] J Viral Hepat. 1995;2(4):165-70 [7489342] J Med Virol. 1995 Nov;47(3):204-8 [8551270] Hepatology. 1996 Jan;23(1):184-6 [8550040] J Virol. 1996 Sep;70(9):5845-51 [8709203] Lancet. 1996 Nov 23;348(9039):1417-9 [8965590] Virology. 1996 Dec 15;226(2):269-80 [8955047] J Hepatol. 1997 Mar;26(3):503-7 [9075656] J Viral Hepat. 1997;4 Suppl 2:25-30 [9429207] Nat Genet. 2005 Aug;37(8):868-72 [16041375] Tissue Antigens. 2006 Feb;67(2):127-33 [16441483] Hepatology. 2006 Sep;44(3):521-6 [16941687] Nat Rev Genet. 2006 Oct;7(10):812-20 [16983377] J Viral Hepat. 1999 Jul;6(4):299-304 [10607244] Gastroenterology. 2000 Mar;118(3):554-9 [10702206] Am J Hum Genet. 2000 Jul;67(1):170-81 [10827107] Hepatology. 2001 Jan;33(1):218-23 [11124839] J Natl Cancer Inst. 2000 Dec 20;92(24):2023-8 [11121465] Cancer Epidemiol Biomarkers Prev. 2001 Feb;10(2):143-6 [11219772] Intervirology. 2001;44(1):43-7 [11223719] Hepatology. 2001 Apr;33(4):963-71 [11283861] J Natl Cancer Inst. 2001 Nov 7;93(21):1644-51 [11698569] Cancer. 2002 May 15;94(10):2663-8 [12173334] Hum Mol Genet. 2003 Apr 15;12(8):901-6 [12668613] Exp Mol Med. 2003 Jun 30;35(3):196-202 [12858019] J Virol. 2003 Nov;77(22):12083-7 [14581545] Hepatology. 2004 Mar;39(3):804-10 [14999700] N Engl J Med. 2004 Oct 7;351(15):1521-31 [15470215] Cancer. 1982 Feb 15;49(4):672-7 [6275976] Clin Exp Immunol. 1998 Mar;111(3):579-82 [9528902] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2334-8-1 ER - TY - JOUR T1 - Dynamics of coactivator recruitment and chromatin modifications during nuclear receptor mediated transcription. AN - 70099499; 17935877 AB - The mechanisms and interplay of coactivators that underlie transcription activation is a critical avenue of investigation in biology today. Using nuclear receptor (NR) mediated transcription activation as a model, the nature of coactivator recruitment and chromatin modifications has been found to be highly dynamic. Progress in understanding the kinetics and regulation of coactivator recruitment, and subsequent effects on transcriptional readout, has greatly improved our understanding of nuclear receptor mediated transcription, the subject of discussion in this 'At the Cutting Edge' review. JF - Molecular and cellular endocrinology AU - Aoyagi, Sayura AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA. Y1 - 2008/01/02/ PY - 2008 DA - 2008 Jan 02 SP - 1 EP - 5 VL - 280 IS - 1-2 SN - 0303-7207, 0303-7207 KW - Nucleosomes KW - 0 KW - Receptors, Cytoplasmic and Nuclear KW - Transcription Factors KW - Index Medicus KW - Animals KW - Models, Genetic KW - Kinetics KW - Humans KW - Nucleosomes -- metabolism KW - Protein Transport KW - Transcription Factors -- metabolism KW - Cell Nucleus -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Chromatin Assembly and Disassembly KW - Transcription, Genetic KW - Transcriptional Activation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70099499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Dynamics+of+coactivator+recruitment+and+chromatin+modifications+during+nuclear+receptor+mediated+transcription.&rft.au=Aoyagi%2C+Sayura%3BArcher%2C+Trevor+K&rft.aulast=Aoyagi&rft.aufirst=Sayura&rft.date=2008-01-02&rft.volume=280&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=03037207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2007-12-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Biochem. 1976;45:721-46 [183602] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):46-51 [15020044] Cell. 1991 Nov 29;67(5):977-86 [1683601] Annu Rev Biochem. 1994;63:451-86 [7979245] Cell. 1995 Dec 15;83(6):835-9 [8521507] Nature. 1997 Jun 12;387(6634):733-6 [9192902] EMBO J. 1998 Mar 2;17(5):1454-66 [9482742] Cell. 1999 Sep 3;98(5):675-86 [10490106] Vitam Horm. 2005;70:281-307 [15727808] J Mol Biol. 2005 Jul 1;350(1):65-77 [15919092] Cell. 2005 Jun 17;121(6):859-72 [15960974] Cell. 2005 Jul 15;122(1):33-43 [16009131] Nat Rev Mol Cell Biol. 2005 Jul;6(7):542-54 [15957004] J Biol Chem. 2005 Sep 23;280(38):32565-8 [16076839] EMBO Rep. 2006 Feb;7(2):161-7 [16452926] Mol Endocrinol. 2006 Mar;20(3):483-90 [16254015] Rev Physiol Biochem Pharmacol. 2006;156:23-43 [16634145] Cell. 2006 May 5;125(3):483-95 [16603237] Cell. 2006 May 5;125(3):411-4 [16678083] Genes Dev. 2006 Jun 1;20(11):1405-28 [16751179] Nature. 2006 Jul 6;442(7098):86-90 [16728976] Cell. 2006 Jul 14;126(1):22-4 [16839870] Mol Cell. 2006 Sep 15;23(6):809-18 [16973433] Biomed Pharmacother. 2006 Nov;60(9):520-8 [16949786] Nat Genet. 2006 Nov;38(11):1289-97 [17013392] Mol Cell Endocrinol. 2007 Feb;265-266:162-7 [17240047] Steroids. 2007 Feb;72(2):221-30 [17291555] Cell. 2007 Feb 23;128(4):693-705 [17320507] Cell. 2007 Feb 23;128(4):707-19 [17320508] Cell. 2007 Feb 23;128(4):787-800 [17320514] Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4852-7 [17360330] Mol Endocrinol. 2007 Apr;21(4):843-56 [17227884] Cell Signal. 2007 Jun;19(6):1101-12 [17368849] Nature. 2007 May 24;447(7143):407-12 [17522673] Cell. 2000 Dec 8;103(6):843-52 [11136970] Science. 2000 Feb 18;287(5456):1262-5 [10678832] PLoS Genet. 2007 Jun;3(6):e87 [17542648] Trends Cell Biol. 2001 Jun;11(6):250-7 [11356361] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7934-9 [12034878] J Biol Chem. 2002 Dec 13;277(50):48366-71 [12376534] J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):139-45 [12943698] Cell. 2003 Dec 12;115(6):751-63 [14675539] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):30-45 [15020043] Mol Cell Biol. 1991 Feb;11(2):688-98 [1846670] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bone morphogenetic protein-7 reduces toxicity induced by high doses of methamphetamine in rodents AN - 20666729; 8097513 AB - Methamphetamine (MA) is a drug of abuse as well as a dopaminergic neurotoxin. We have previously demonstrated that pretreatment with bone morphogenetic protein 7 (BMP7) reduced 6-hydroxydopamine-mediated neurodegeneration in a rodent model of Parkinson's disease. In this study, we examined the neuroprotective effects of BMP7 against MA-mediated toxicity in dopaminergic neurons. Primary dopaminergic neurons, prepared from rat embryonic ventral mesencephalic tissue, were treated with MA. High doses of MA decreased tyrosine hydroxylase immunoreactivity (THir) while increasing terminal deoxynucleotidyl transferase-mediated dNTP nick end labeling. These toxicities were significantly antagonized by BMP7. Interaction of BMP7 and MA in vivo was first examined in CD1 mice. High doses of MA (10 mg/kgx4 s.c.) significantly reduced locomotor activity and THir in striatum. I.c.v. administration of BMP7 antagonized these changes. In BMP7 +/- mice, MA suppressed locomotor activity and reduced TH immunoreactivity in nigra reticulata to a greater degree than in wild type BMP7 +/+ mice, suggesting that deficiency in BMP7 expression increases vulnerability to MA insults. Since BMP7 +/- mice also carry a LacZ-expressing reporter allele at the BMP7 locus, the expression of BMP7 was indirectly measured through the enzymatic activity of beta -galactosidase ( beta -gal) in BMP7 +/- mice. High doses of MA significantly suppressed beta -gal activity in striatum, suggesting that MA may inhibit BMP7 expression at the terminals of the nigrostriatal pathway. A similar effect was also found in CD1 mice in that high doses of MA suppressed BMP7 mRNA expression in nigra. In conclusion, our data indicate that MA can cause lesioning in the nigrostriatal dopaminergic terminals and that BMP7 is protective against MA-mediated neurotoxicity in central dopaminergic neurons. end labeling JF - Neuroscience AU - Chou, J AU - Luo, Y AU - Kuo, C C AU - Powers, K AU - Shen, H AU - Harvey, B K AU - Hoffer, B J AU - Wang, Y AD - Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA, ywang@intra.nida.nih.gov Y1 - 2008/01/02/ PY - 2008 DA - 2008 Jan 02 SP - 92 EP - 103 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 151 IS - 1 SN - 0306-4522, 0306-4522 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Bone morphogenetic protein 7 KW - Data processing KW - beta -Galactosidase KW - Parkinson's disease KW - Animal models KW - Neuroprotection KW - Drug abuse KW - Neurodegeneration KW - Gene expression KW - Neurodegenerative diseases KW - Methamphetamine KW - Nervous system KW - Movement disorders KW - Dopamine KW - Locomotor activity KW - Neostriatum KW - Immunoreactivity KW - Neurotoxicity KW - Embryos KW - Enzymatic activity KW - Tyrosine 3-monooxygenase KW - Neurotoxins KW - X 24380:Social Poisons & Drug Abuse KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20666729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Bone+morphogenetic+protein-7+reduces+toxicity+induced+by+high+doses+of+methamphetamine+in+rodents&rft.au=Chou%2C+J%3BLuo%2C+Y%3BKuo%2C+C+C%3BPowers%2C+K%3BShen%2C+H%3BHarvey%2C+B+K%3BHoffer%2C+B+J%3BWang%2C+Y&rft.aulast=Chou&rft.aufirst=J&rft.date=2008-01-02&rft.volume=151&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/10.1016%2Fj.neuroscience.2007.10.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bone morphogenetic protein 7; Data processing; beta -Galactosidase; Parkinson's disease; Animal models; Neuroprotection; Drug abuse; Neurodegeneration; Gene expression; Neurodegenerative diseases; Nervous system; Methamphetamine; Dopamine; Movement disorders; Locomotor activity; Neurotoxicity; Immunoreactivity; Neostriatum; Embryos; Enzymatic activity; Neurotoxins; Tyrosine 3-monooxygenase DO - http://dx.doi.org/10.1016/j.neuroscience.2007.10.044 ER - TY - JOUR T1 - IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages AN - 19894235; 7956684 AB - Objective: IL-27 is a novel anti-HIV cytokine that inhibits HIV-1 replication in both CD4 T cells and monocyte-derived macrophages (MDM) as IFN- alpha does. To elucidate the mechanism of the antiviral activity, we compared the activity and the gene expression profile of IL-27-treated cells with that of IFN- alpha -treated cells. Methods: CD4 T cells and monocytes were isolated from peripheral blood mono-nuclear cells of healthy donors. CD4 T cells were stimulated with phytohemagglutinin, and MDM were induced from monocytes using macrophage-colony stimulating factor. HIV-1 replication was monitored by p24 antigen capture assay. The gene expression profiles were analysed using DNA microarray analysis. The increase in the expression of IFN-inducible genes (IFIG) was confirmed by the Quantigene plex assay. Results: Both cytokines preferentially inhibited HIV-1 replication in MDM compared with CD4 T cells. Quantitative real time polymerase chain reaction, enzyme-linked immunosorbent assay and neutralization assay using anti-IFN indicated that IFN- alpha , IFN- beta and IFN- gamma had no significant impact on IL-27-mediated HIV inhibition. DNA microarray analysis illustrated that IFN- alpha induced 33 and 18 IFIG in MDM and CD4 T cells, respectively. IL-27 induced 28 IFIG in MDM and five IFIG in CD4 T cells. The quantitative assay confirmed that IL-27 activated genes of RNA-dependent kinase, oligoadenylate synthetase, myxovirus protein, and apolipoprotein B messenger RNA-editing enzyme-catalytic polypeptide-like 3G. Conclusion: IL-27 differentially regulates the gene expression between CD4 T cells and MDM. IL-27 significantly induces antiviral genes in MDM as does IFN- alpha , suggesting that IL-27 inhibits HIV replication in MDM via mechanism(s) similar to that of IFN- alpha . JF - AIDS AU - Imamichi, T AU - Yang, J AU - Huang, D-W AU - Brann, T W AU - Fullmer, BA AU - Adelsberger, J W AU - Lempicki, R A AU - Baseler, M W AU - Lane, H C AD - Building 550, Room 126, SAIC-Frederick, Inc., NCI-Frederick, PO Box B, Frederick, MD 21702-1201, USA, timamichi@mail.nih.gov Y1 - 2008/01/02/ PY - 2008 DA - 2008 Jan 02 SP - 39 EP - 45 VL - 22 IS - 1 SN - 0269-9370, 0269-9370 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - beta -Interferon KW - Macrophages KW - gamma -Interferon KW - p24 protein KW - Enzyme-linked immunosorbent assay KW - Apolipoprotein B KW - Replication KW - Peripheral blood KW - Macrophage colony-stimulating factor KW - phytohemagglutinins KW - Antiviral activity KW - DNA microarrays KW - Gene expression KW - CD4 antigen KW - Human immunodeficiency virus KW - Human immunodeficiency virus 1 KW - alpha -Interferon KW - Interleukin 27 KW - Lymphocytes T KW - Polymerase chain reaction KW - Monocytes KW - G 07720:Immunogenetics KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19894235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=IL-27%2C+a+novel+anti-HIV+cytokine%2C+activates+multiple+interferon-inducible+genes+in+macrophages&rft.au=Imamichi%2C+T%3BYang%2C+J%3BHuang%2C+D-W%3BBrann%2C+T+W%3BFullmer%2C+BA%3BAdelsberger%2C+J+W%3BLempicki%2C+R+A%3BBaseler%2C+M+W%3BLane%2C+H+C&rft.aulast=Imamichi&rft.aufirst=T&rft.date=2008-01-02&rft.volume=22&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Macrophages; beta -Interferon; p24 protein; gamma -Interferon; Apolipoprotein B; Enzyme-linked immunosorbent assay; Replication; Peripheral blood; Macrophage colony-stimulating factor; Antiviral activity; phytohemagglutinins; DNA microarrays; Gene expression; CD4 antigen; Interleukin 27; alpha -Interferon; Lymphocytes T; Polymerase chain reaction; Monocytes; Human immunodeficiency virus; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD AN - 19468490; 7936212 AB - The sporadic nature of Alzheimer's disease (AD) argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic beta -amyloid (A beta ) product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ( beta -site APP cleaving enzyme 1)] as well as their transcriptional regulator (Sp1) were elevated in aged (23-year-old) monkeys exposed to Pb as infants. Furthermore, developmental exposure to Pb altered the levels, characteristics, and intracellular distribution of A beta staining and amyloid plaques in the frontal association cortex. These latent effects were accompanied by a decrease in DNA methyltransferase activity and higher levels of oxidative damage to DNA, indicating that epigenetic imprinting in early life influenced the expression of AD-related genes and promoted DNA damage and pathogenesis. These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. JF - Journal of Neuroscience AU - Wu, Jinfang AU - Basha, MdRiyaz AU - Brock, Brian AU - Cox, David P AU - Cardozo-Pelaez, Fernando AU - McPherson, Christopher A AU - Harry, Jean AU - Rice, Deborah C AU - Maloney, Bryan AU - Chen, Demao AU - Lahiri, Debomoy K AU - Zawia, Nasser H AD - Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, National Institutes of Health, Research Triangle Park, North Carolina 27709, Maine Department of Health and Human Services, Augusta, Maine 04333, and Laboratory for Molecular Neurogenetics, Institute for Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 Y1 - 2008/01/02/ PY - 2008 DA - 2008 Jan 02 SP - 3 EP - 9 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 28 IS - 1 SN - 0270-6474, 0270-6474 KW - Genetics Abstracts; Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Data processing KW - Chromium KW - Heavy metals KW - Alzheimer's disease KW - Brain KW - Cortex (frontal) KW - Transcription KW - Imprinting KW - Lead KW - Amyloidogenesis KW - Amyloid precursor protein KW - DNA damage KW - Neurodegenerative diseases KW - Sp1 protein KW - Cortex KW - beta -Site APP cleaving enzyme 1 KW - epigenetics KW - Geriatrics KW - DNA methyltransferase KW - Plaques KW - beta -Amyloid KW - Secretase KW - Infants KW - N 14820:DNA Metabolism & Structure KW - N3 11028:Neuropharmacology & toxicology KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19468490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Alzheimer%27s+Disease+%28AD%29-Like+Pathology+in+Aged+Monkeys+after+Infantile+Exposure+to+Environmental+Metal+Lead+%28Pb%29%3A+Evidence+for+a+Developmental+Origin+and+Environmental+Link+for+AD&rft.au=Wu%2C+Jinfang%3BBasha%2C+MdRiyaz%3BBrock%2C+Brian%3BCox%2C+David+P%3BCardozo-Pelaez%2C+Fernando%3BMcPherson%2C+Christopher+A%3BHarry%2C+Jean%3BRice%2C+Deborah+C%3BMaloney%2C+Bryan%3BChen%2C+Demao%3BLahiri%2C+Debomoy+K%3BZawia%2C+Nasser+H&rft.aulast=Wu&rft.aufirst=Jinfang&rft.date=2008-01-02&rft.volume=28&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Chromium; Heavy metals; Alzheimer's disease; Brain; Transcription; Cortex (frontal); Imprinting; Amyloidogenesis; Lead; Amyloid precursor protein; Sp1 protein; Neurodegenerative diseases; DNA damage; Cortex; beta -Site APP cleaving enzyme 1; epigenetics; Geriatrics; DNA methyltransferase; Plaques; Secretase; beta -Amyloid; Infants ER - TY - JOUR T1 - The identification and comparison of the bio-elements of the penguin ornithogenic sediments sample from Davis Station and Great Wall Station AN - 886907046; 2011-074529 AB - During CHINARE-22 in the austral summer of 2005-2006, a lake sediment core named DG4, which was impacted by penguin droppings, was retrieved from a lake catchment on Gardner Island in the Vestfold Hills, East Antarctica. In this study, the concentrations of characteristic elements in the core, local bedrock, and fresh penguin guano were determined. P, Se, F, S, As, Sr and Cu in DG4 were identified as the bio-element assemblage by R-clustering analysis and compared with those in the local bedrock and fresh guano, and the results are similar to Y2 on Ardley Island, Antarctic Peninsula. On this basis, P and Se were identified as the optimum bio-elements in DG4, and F, P and S were identified in Y2. This work provides a foundation for reconstructing past penguin populations on Gardner Island and for comparing penguin population dynamics between East Antarctica and the Antarctic Peninsula. JF - Chinese Journal of Polar Science AU - Huang, Tao AU - Sun, Liguang AU - Wang, Yuhong AU - Zhu, Renbin Y1 - 2008 PY - 2008 DA - 2008 SP - 36 EP - 44 PB - Science Press, Beijing VL - 19 IS - 1 SN - 1007-7065, 1007-7065 KW - selenium KW - halogens KW - cores KW - guano KW - Davis Station KW - fluorine KW - sediments KW - Great Wall Station KW - chemical composition KW - geochemistry KW - Neornithes KW - Chordata KW - Vestfold Hills KW - phosphorus KW - East Antarctica KW - samples KW - Aves KW - Antarctica KW - Sphenisciformes KW - Gardner Island KW - identification KW - lacustrine environment KW - sulfur KW - Vertebrata KW - Tetrapoda KW - lake sediments KW - 06A:Sedimentary petrology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/886907046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Polar+Science&rft.atitle=The+identification+and+comparison+of+the+bio-elements+of+the+penguin+ornithogenic+sediments+sample+from+Davis+Station+and+Great+Wall+Station&rft.au=Huang%2C+Tao%3BSun%2C+Liguang%3BWang%2C+Yuhong%3BZhu%2C+Renbin&rft.aulast=Huang&rft.aufirst=Tao&rft.date=2008-01-01&rft.volume=19&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Polar+Science&rft.issn=10077065&rft_id=info:doi/ L2 - http://journal.polar.gov.cn/EN/column/column79.shtml LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2011-01-01 N1 - Number of references - 25 N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Antarctica; Aves; chemical composition; Chordata; cores; Davis Station; East Antarctica; fluorine; Gardner Island; geochemistry; Great Wall Station; guano; halogens; identification; lacustrine environment; lake sediments; Neornithes; phosphorus; samples; sediments; selenium; Sphenisciformes; sulfur; Tetrapoda; Vertebrata; Vestfold Hills ER - TY - JOUR T1 - The effect of surface electrical stimulation on vocal fold position. AN - 85406167; pmid-18043496 AB - Closure of the true and false vocal folds is a normal part of airway protection during swallowing. Individuals with reduced or delayed true vocal fold closure can be at risk for aspiration and may benefit from intervention to ameliorate the problem. Surface electrical stimulation is currently used during therapy for dysphagia, despite limited knowledge of its physiological effects.Prospective single effects study.The immediate physiological effect of surface stimulation on true vocal fold angle was examined at rest in 27 healthy adults using 10 different electrode placements on the submental and neck regions. Fiberoptic nasolaryngoscopic recordings during passive inspiration were used to measure change in true vocal fold angle with stimulation.Vocal fold angles changed only to a small extent during two electrode placements (P < or = .05). When two sets of electrodes were placed vertically on the neck, the mean true vocal fold abduction was 2.4 degrees; while horizontal placements of electrodes in the submental region produced a mean adduction of 2.8 degrees (P = .03).Surface electrical stimulation to the submental and neck regions does not produce immediate true vocal fold adduction adequate for airway protection during swallowing, and one position may produce a slight increase in true vocal fold opening. JF - The Laryngoscope AU - Humbert, Ianessa A AU - Poletto, Christopher J AU - Saxon, Keith G AU - Kearney, Pamela R AU - Ludlow, Christy L AD - Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke/NIH, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 14 EP - 19 VL - 118 IS - 1 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Deglutition: physiology KW - Electric Stimulation: instrumentation KW - Electrodes KW - Female KW - Humans KW - Inhalation: physiology KW - Laryngeal Muscles: physiology KW - Laryngoscopy: methods KW - Male KW - Middle Aged KW - Movement KW - Neck KW - Prospective Studies KW - *Vocal Cords: anatomy & histology KW - Vocal Cords: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85406167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=The+effect+of+surface+electrical+stimulation+on+vocal+fold+position.&rft.au=Humbert%2C+Ianessa+A%3BPoletto%2C+Christopher+J%3BSaxon%2C+Keith+G%3BKearney%2C+Pamela+R%3BLudlow%2C+Christy+L&rft.aulast=Humbert&rft.aufirst=Ianessa&rft.date=2008-01-01&rft.volume=118&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Cites: Respir Care. 2001 May;46(5):466-74[11309186]; Cites: Otolaryngol Head Neck Surg. 1997 Mar;116(3):349-54[9121789]; Cites: Laryngoscope. 2002 Aug;112(8 Pt 1):1407-13[12172253]; Cites: Ann Otol Rhinol Laryngol. 2002 Aug;111(8):672-9[12184586]; Cites: Laryngoscope. 2002 Dec;112(12):2204-10[12461342]; Cites: J Appl Physiol. 2003 Jan;94(1):128-34[12486019]; Cites: Br J Radiol. 1956 Apr;29(340):205-8[13315996]; Cites: Br J Radiol. 1952 Aug;25(296):406-16[14935150]; Cites: Am J Physiol. 1992 Feb;262(2 Pt 1):G338-44[1539666]; Cites: Acta Otolaryngol. 1992;112(2):353-7[1605006]; Cites: Dysphagia. 2005 Spring;20(2):163-7; discussion 168-9[16172827]; Cites: Dysphagia. 2007 Jan;22(1):1-10[16718620]; Cites: J Appl Physiol. 2006 Dec;101(6):1657-63[16873602]; Cites: Otolaryngol Head Neck Surg. 1999 Apr;120(4):474-8[10187936]; Cites: J Appl Physiol. 1999 May;86(5):1663-9[10233133]; Cites: Muscle Nerve. 2000 Jan;23(1):44-57[10590405]; Cites: Laryngoscope. 2000 Jun;110(6):1018-25[10852524]; Cites: Gastroenterology. 1990 Jun;98(6):1478-84[2338189]; Cites: Laryngoscope. 2000 Nov;110(11):1943-9[11081615]; Cites: Auris Nasus Larynx. 2001 Jan;28(1):75-84[11137367]; Cites: Arch Otorhinolaryngol. 1989;246(5):397-402[2590059]; Cites: Laryngoscope. 2001 Nov;111(11 Pt 1):2032-40[11801992] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Paging equals functionality. AN - 85404286; pmid-18078542 JF - Journal of the International Neuropsychological Society : JINS AU - Grafman, Jordan AD - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1440, USA. grafmanj@ninds.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 152 EP - 153 VL - 14 IS - 1 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Brain Injuries: complications KW - *Communication Aids for Disabled KW - Humans KW - Memory Disorders: etiology KW - *Memory Disorders: rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85404286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Paging+equals+functionality.&rft.au=Grafman%2C+Jordan&rft.aulast=Grafman&rft.aufirst=Jordan&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment On: J Int Neuropsychol Soc. 2008 Jan;14(1):154-63[18078543] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit AN - 839576481; 201103537 AB - Background: Pediatric bipolar disorder (BD), a highly debilitating illness, is characterized by amygdala abnormalities, i.e., volume reduction and hyperactivation during face processing. Evidence of perturbed amygdala functional connectivity with other brain regions would implicate a distributed neural circuit in the pathophysiology of BD, and would further elucidate the neural mechanisms associated with BD face emotion misinterpretation. Methods: Thirty-three BD and 24 healthy age, gender, and IQ-matched subjects completed a functional magnetic resonance imaging (fMRI) task of face emotion identification in which attention was directed to emotional (hostility, fearfulness) and nonemotional (nose width) aspects of faces. Voxel-wise analyses examined whole brain functional connectivity with the left amygdala. Results: Compared to healthy subjects, BD subjects had significantly reduced connectivity between the left amygdala and two regions: right posterior cingulate/precuneus and right fusiform gyrus/parahippocampal gyrus. Deficits were evident regardless of mood state and comorbid diagnoses. Conclusions: BD youth exhibit deficient connectivity between the amygdala and temporal association cortical regions previously implicated in processing facial expressions and social stimuli. In conjunction with previously documented volumetric and functional perturbations in these brain regions, dysfunction in this distributed neural circuit may begin to clarify the pathophysiology of the face emotion misperceptions and social deficits seen in BD youth. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Rich, Brendan A AU - Fromm, Stephen J AU - Berghorst, Lisa H AU - Dickstein, Daniel P AU - Brotman, Melissa A AU - Pine, Daniel S AU - Leibenluft, Ellen Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 88 EP - 96 PB - Blackwell Publishing, Oxford UK VL - 49 IS - 1 SN - 0021-9630, 0021-9630 KW - Bipolar disorder KW - children KW - face perception KW - neural connectivity KW - amygdala KW - Pathophysiological aspects KW - Emotions KW - Facial expressions KW - Bipolar affective disorder KW - Brain KW - Circuits KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839576481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Neural+connectivity+in+children+with+bipolar+disorder%3A+impairment+in+the+face+emotion+processing+circuit&rft.au=Rich%2C+Brendan+A%3BFromm%2C+Stephen+J%3BBerghorst%2C+Lisa+H%3BDickstein%2C+Daniel+P%3BBrotman%2C+Melissa+A%3BPine%2C+Daniel+S%3BLeibenluft%2C+Ellen&rft.aulast=Rich&rft.aufirst=Brendan&rft.date=2008-01-01&rft.volume=49&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2007.01819.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Emotions; Facial expressions; Brain; Circuits; Bipolar affective disorder; Pathophysiological aspects DO - http://dx.doi.org/10.1111/j.1469-7610.2007.01819.x ER - TY - JOUR T1 - Development and validation of a liquid chromatography--tandem mass spectrometry assay for the simultaneous quantification of buprenorphine, norbuprenorphine, and metabolites in human urine AN - 753652594; 13323452 AB - A liquid chromatography--tandem mass spectrometry method for the simultaneous quantification of buprenorphine (BUP), norbuprenorphine (NBUP), buprenorphine glucuronide (BUP-Gluc), and norbuprenorphine glucuronide (NBUP-Gluc) in human urine was developed and fully validated. Extensive endogenous and exogenous interferences were evaluated and limits of quantification were identified empirically. Analytical ranges were 5--1,000 ng/mL for BUP and BUP-Gluc and 25--1,000 ng/mL for NBUP and NBUP-Gluc. Intra-assay and interassay imprecision were less than 17% and recovery was 93--116%. Analytes were stable at room temperature, at 4 C, and for three freeze--thaw cycles. This accurate and precise assay has sufficient sensitivity and specificity for urine analysis of specimens collected from individuals treated with BUP for opioid dependence. JF - Analytical and Bioanalytical Chemistry AU - Kacinko, Sherri L AU - Concheiro-Guisan, Marta AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Suite 200, Room 05A-721, 251 Bayview Blvd., Baltimore, MD 21224, USA, mhuestis@intra.nida.nih.gov PY - 2008 SP - 903 EP - 911 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 392 IS - 5 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Mass Spectrometry KW - Urine KW - Assay KW - Temperature KW - Metabolites KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753652594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Development+and+validation+of+a+liquid+chromatography--tandem+mass+spectrometry+assay+for+the+simultaneous+quantification+of+buprenorphine%2C+norbuprenorphine%2C+and+metabolites+in+human+urine&rft.au=Kacinko%2C+Sherri+L%3BConcheiro-Guisan%2C+Marta%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Kacinko&rft.aufirst=Sherri&rft.date=2008-01-01&rft.volume=392&rft.issue=5&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-008-2326-z L2 - http://www.springerlink.com/content/d501r1u2gt8354h6/?p=7ca61884e43d43e483aedc13ceee9a72&pi=20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Mass Spectrometry; Urine; Temperature; Assay; Metabolites DO - http://dx.doi.org/10.1007/s00216-008-2326-z ER - TY - JOUR T1 - The intrinsic and extrinsic aspects of freezing of gait. AN - 742779582; pmid-18668625 AB - Freezing of gait appears to result from a number of fundamental problems in patients with Parkinson disease. Automaticity is impaired, putting more stress on voluntary mechanisms. Internal drivers of movement are impaired, likely because of deficient basal ganglia function. Deficiency of internal forces to initiate movement is a major factor in freezing. This deficiency gives a greater influence to external or sensory factors. The sensory factors can both help or hinder freezing. Analogous to the problem with set-shifting, there is also some difficulty in regulation of internal versus external factors and in regulation of different external factors. (c) 2008 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Hallett, Mark AD - Human Motor Control Section, NINDS, NIH, Bethesda, Maryland 20892-1428, USA. hallettm@ninds.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S439 EP - S443 VL - 23 Suppl 2 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Parkinson Disease -- complications KW - Physical Stimulation KW - Psychomotor Performance -- physiology KW - Freezing Reaction, Cataleptic -- physiology KW - Locomotion -- physiology KW - Gait -- physiology KW - Gait Disorders, Neurologic -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742779582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=The+intrinsic+and+extrinsic+aspects+of+freezing+of+gait.&rft.au=Hallett%2C+Mark&rft.aulast=Hallett&rft.aufirst=Mark&rft.date=2008-01-01&rft.volume=23+Suppl+2&rft.issue=&rft.spage=S439&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - SuppNotes - Erratum In: Mov Disord. 2008 Aug 15;23(11):1639-40 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - PPARgamma and Proline Oxidase in Cancer. AN - 733667906; 18670615 AB - Proline is metabolized by its own specialized enzymes with their own tissue and subcellular localizations and mechanisms of regulation. The central enzyme in this metabolic system is proline oxidase, a flavin adenine dinucleotide-containing enzyme which is tightly bound to mitochondrial inner membranes. The electrons from proline can be used to generate ATP or can directly reduce oxygen to form superoxide. Although proline may be derived from the diet and biosynthesized endogenously, an important source in the microenvironment is from degradation of extracellular matrix by matrix metalloproteinases. Previous studies showed that proline oxidase is a p53-induced gene and its overexpression can initiate proline-dependent apoptosis by both intrinsic and extrinsic pathways. Another important factor regulating proline oxidase is peroxisome proliferator activated receptor gamma (PPARgamma). Importantly, in several cancer cells, proline oxidase may be an important mediator of the PPARgamma-stimulated generation of ROS and induction of apoptosis. Knockdown of proline oxidase expression by antisense RNA markedly decreased these PPARgamma-stimulated effects. These findings suggest an important role in the proposed antitumor effects of PPARgamma. Moreover, it is possible that proline oxidase may contribute to the other metabolic effects of PPARgamma. JF - PPAR research AU - Phang, James M AU - Pandhare, Jui AU - Zabirnyk, Olga AU - Liu, Yongmin AD - Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 542694 VL - 2008 SN - 1687-4757, 1687-4757 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733667906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PPAR+research&rft.atitle=PPARgamma+and+Proline+Oxidase+in+Cancer.&rft.au=Phang%2C+James+M%3BPandhare%2C+Jui%3BZabirnyk%2C+Olga%3BLiu%2C+Yongmin&rft.aulast=Phang&rft.aufirst=James&rft.date=2008-01-01&rft.volume=2008&rft.issue=&rft.spage=542694&rft.isbn=&rft.btitle=&rft.title=PPAR+research&rft.issn=16874757&rft_id=info:doi/10.1155%2F2008%2F542694 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2008-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biochem. 2007 Jan;295(1-2):85-92 [16874462] Biochem Biophys Res Commun. 2000 Sep 24;276(2):718-23 [11027537] J Biol Chem. 2006 Nov 3;281(44):33045-52 [16914544] J Biol Chem. 2007 May 11;282(19):14316-27 [17344208] Oncogene. 2006 Sep 14;25(41):5640-7 [16619034] Gut. 2006 Sep;55(9):1341-9 [16905700] Cancer Metastasis Rev. 2006 Mar;25(1):9-34 [16680569] FEBS J. 2006 May;273(9):1975-88 [16640561] Oncogene. 2006 Apr 13;25(16):2304-17 [16331265] Carcinogenesis. 2005 Aug;26(8):1335-42 [15817612] Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H852-61 [15805232] Breast Cancer Res Treat. 2008 Mar;108(1):23-33 [17453334] Curr Mol Med. 2007 Sep;7(6):532-40 [17896990] Bone. 2007 Oct;41(4):562-74 [17669705] Clin Biochem. 2007 Oct;40(15):1129-34 [17673194] Mol Pharmacol. 2007 Sep;72(3):674-85 [17535976] Cancer. 2007 Aug 15;110(4):791-800 [17582802] Biochim Biophys Acta. 2007 Aug;1771(8):1014-30 [17418635] FEBS Lett. 2007 Jul 10;581(17):3303-10 [17597617] Cells Tissues Organs. 2007;185(1-3):104-10 [17587815] Endocrinology. 2007 Jun;148(6):2669-80 [17332064] J Clin Oncol. 2007 Apr 20;25(12):1476-81 [17442990] Endocrinology. 2007 May;148(5):2085-94 [17289842] Cancer Res. 2006 Mar 1;66(5):2691-9 [16510589] J Clin Invest. 2006 Mar;116(3):581-9 [16511590] Naturwissenschaften. 2006 Feb;93(2):72-9 [16365739] J Biol Chem. 2006 Jan 27;281(4):2044-52 [16303758] Cancer Res. 2006 Jan 1;66(1):412-8 [16397256] Cell. 2005 Dec 16;123(6):993-9 [16360030] Nat Rev Immunol. 2005 Nov;5(11):844-52 [16239903] Trends Biochem Sci. 1999 Feb;24(2):68-72 [10098401] Nat Genet. 1999 Apr;21(4):434-9 [10192398] Nat Med. 1998 Sep;4(9):1053-7 [9734399] Nature. 1998 Sep 10;395(6698):137-43 [9744270] Cell. 1998 Apr 17;93(2):229-40 [9568715] Nature. 1997 Sep 18;389(6648):300-5 [9305847] Cell. 1997 Feb 7;88(3):323-31 [9039259] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2979-83 [8096642] J Biol Chem. 1992 Jun 5;267(16):10931-4 [1375931] Neuron. 1992 May;8(5):915-26 [1350201] Curr Top Cell Regul. 1985;25:91-132 [2410198] Arch Biochem Biophys. 1986 Jul;248(1):166-74 [3729412] Carcinogenesis. 1985 Apr;6(4):501-4 [3986956] Arch Biochem Biophys. 1983 Aug;225(1):95-101 [6688511] J Parasitol. 1983 Apr;69(2):290-4 [6854470] Biochem Biophys Res Commun. 1980 Mar 28;93(2):462-70 [6892988] Eur J Biochem. 1977 Dec;81(3):599-607 [598383] Int Rev Connect Tissue Res. 1970;5:1-91 [5500436] Nat Rev Immunol. 2004 Aug;4(8):617-29 [15286728] J Biol Chem. 2003 Mar 14;278(11):9784-9 [12514185] Bioessays. 2003 Feb;25(2):174-81 [12539244] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3717-22 [11891283] J Biol Chem. 2002 Feb 8;277(6):4223-31 [11704682] J Mol Endocrinol. 2001 Aug;27(1):1-9 [11463572] Cancer Res. 2001 Mar 1;61(5):1810-5 [11280728] Endocr Rev. 2006 Dec;27(7):728-35 [17018837] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1155/2008/542694 ER - TY - JOUR T1 - An update on adenosine A2A-dopamine D2 receptor interactions: implications for the function of G protein-coupled receptors. AN - 71656685; 18537670 AB - Adenosine A(2A)-dopamine D(2) receptor interactions play a very important role in striatal function. A(2A)-D(2) receptor interactions provide an example of the capabilities of information processing by just two different G protein-coupled receptors. Thus, there is evidence for the coexistence of two reciprocal antagonistic interactions between A(2A) and D(2) receptors in the same neurons, the GABAergic enkephalinergic neurons. An antagonistic A(2A)-D(2) intramembrane receptor interaction, which depends on A(2A)-D(2) receptor heteromerization and G(q/11)-PLC signaling, modulates neuronal excitability and neurotransmitter release. On the other hand, an antagonistic A(2A)-D(2) receptor interaction at the adenylyl-cyclase level, which depends on G(s/olf)- and G(i/o)-type V adenylyl-cyclase signaling, modulates protein phosphorylation and gene expression. Finally, under conditions of upregulation of an activator of G protein signaling (AGS3), such as during chronic treatment with addictive drugs, a synergistic A(2A)-D(2) receptor interaction can also be demonstrated. AGS3 facilitates a synergistic interaction between G(s/olf) - and G(i/o)-coupled receptors on the activation of types II/IV adenylyl cyclase, leading to a paradoxical increase in protein phosphorylation and gene expression upon co-activation of A(2A) and D(2) receptors. The analysis of A(2)-D(2) receptor interactions will have implications for the pathophysiology and treatment of basal ganglia disorders and drug addiction. JF - Current pharmaceutical design AU - Ferré, S AU - Quiroz, C AU - Woods, A S AU - Cunha, R AU - Popoli, P AU - Ciruela, F AU - Lluis, C AU - Franco, R AU - Azdad, K AU - Schiffmann, S N AD - National Institute on Drug Abuse, IRP, NIH, DHHS, 5500 Nathan Shock Dr., Baltimore, MD 21224, USA. sferre@intra.nida.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1468 EP - 1474 VL - 14 IS - 15 KW - Adenosine A2 Receptor Agonists KW - 0 KW - Adenosine A2 Receptor Antagonists KW - Dopamine D2 Receptor Antagonists KW - Enkephalins KW - Receptor, Adenosine A2A KW - Receptors, Dopamine D2 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Substance-Related Disorders -- physiopathology KW - Animals KW - Neurons -- metabolism KW - Enzyme Activation KW - Humans KW - Adenylyl Cyclases -- metabolism KW - Basal Ganglia -- physiology KW - GTP-Binding Proteins -- physiology KW - Phosphorylation KW - Basal Ganglia Diseases -- drug therapy KW - Substance-Related Disorders -- drug therapy KW - Enkephalins -- metabolism KW - Basal Ganglia Diseases -- physiopathology KW - gamma-Aminobutyric Acid -- metabolism KW - Receptor, Adenosine A2A -- physiology KW - Receptors, Dopamine D2 -- agonists KW - Receptors, Dopamine D2 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71656685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+design&rft.atitle=An+update+on+adenosine+A2A-dopamine+D2+receptor+interactions%3A+implications+for+the+function+of+G+protein-coupled+receptors.&rft.au=Ferr%C3%A9%2C+S%3BQuiroz%2C+C%3BWoods%2C+A+S%3BCunha%2C+R%3BPopoli%2C+P%3BCiruela%2C+F%3BLluis%2C+C%3BFranco%2C+R%3BAzdad%2C+K%3BSchiffmann%2C+S+N&rft.aulast=Ferr%C3%A9&rft.aufirst=S&rft.date=2008-01-01&rft.volume=14&rft.issue=15&rft.spage=1468&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+design&rft.issn=1873-4286&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-24 N1 - Date created - 2008-06-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Pharmacol Sci. 2005 Sep;26(9):470-6 [16084602] Science. 2005 Oct 7;310(5745):113-6 [16210541] J Neurosci. 2005 Nov 9;25(45):10414-9 [16280580] J Biol Chem. 2005 Dec 2;280(48):40144-51 [16195233] J Neurochem. 2006 Jan;96(2):482-8 [16336634] J Integr Neurosci. 2005 Dec;4(4):445-64 [16385640] J Neurosci. 2006 Feb 15;26(7):2080-7 [16481441] Mol Pharmacol. 2006 Jun;69(6):1905-12 [16501032] Exp Neurol. 2006 Nov;202(1):255-7 [16808917] Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):654-9 [17194762] J Recept Signal Transduct Res. 2007;27(1):47-65 [17365509] Pharmacol Rev. 2001 Dec;53(4):527-52 [11734617] Neurosci Lett. 2002 May 17;324(2):154-8 [11988350] J Biol Chem. 2002 May 17;277(20):18091-7 [11872740] Br J Pharmacol. 2002 May;136(2):296-302 [12010779] Cell. 2002 Jun 14;109(6):733-43 [12086672] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11940-5 [12189203] J Neurosci. 2002 Sep 15;22(18):7931-40 [12223546] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1322-7 [12538871] J Mol Biol. 2003 Jun 13;329(4):815-29 [12787680] J Biol Chem. 2003 Jun 13;278(24):21655-62 [12663652] Biochem Biophys Res Commun. 2003 Jun 27;306(2):544-9 [12804599] Neuropsychopharmacology. 2003 Jul;28(7):1317-27 [12784121] Pharmacol Rev. 2003 Sep;55(3):509-50 [12869660] Trends Neurosci. 2003 Oct;26(10):536-42 [14522146] J Biol Chem. 2003 Nov 21;278(47):46741-9 [12933819] Neuron. 2004 Apr 22;42(2):269-81 [15091342] Parkinsonism Relat Disord. 2004 Jul;10(5):273-80 [15196505] Anal Chem. 2004 Sep 15;76(18):5354-63 [15362892] Eur J Pharmacol. 1991 Jan 3;192(1):25-30 [1828236] Eur J Pharmacol. 1991 Jan 3;192(1):31-7 [1828237] J Neurochem. 1991 Sep;57(3):1062-7 [1713612] J Neurochem. 2000 Jan;74(1):432-9 [10617149] Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1856-60 [10677546] Trends Neurosci. 2007 May;30(5):228-35 [17408758] Brain Res Rev. 2007 Aug;55(1):55-67 [17408563] Trends Neurosci. 2007 Sep;30(9):440-6 [17692396] Neuropharmacology. 2007 Nov;53(6):783-9 [17889039] Neuropsychopharmacology. 2007 Nov;32(11):2249-59 [17356572] ScientificWorldJournal. 2007;7:48-57 [17982576] ScientificWorldJournal. 2007;7:74-85 [17982579] Prog Neurobiol. 2007 Dec;83(5):332-47 [17532111] Prog Neurobiol. 2007 Dec;83(5):277-92 [17646043] Pharmacol Ther. 2007 Dec;116(3):343-54 [17935788] Recent Pat CNS Drug Discov. 2007 Jan;2(1):1-21 [18221214] Neuropsychopharmacology. 2001 Oct;25(4):505-13 [11557164] Cell Signal. 2000 Apr;12(4):195-204 [10781926] Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8606-11 [10890919] Neuroscience. 2000;100(1):53-62 [10996458] J Biol Chem. 2000 Oct 20;275(42):32672-80 [10926927] Am J Psychiatry. 2000 Nov;157(11):1738-51 [11058466] Eur J Neurosci. 2000 Nov;12(11):4033-7 [11069599] J Neurosci. 2001 Jan 15;21(2):628-40 [11160442] J Biol Chem. 2001 May 25;276(21):18345-51 [11278325] Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7617-22 [11390975] Neuroreport. 2001 Jul 3;12(9):1831-4 [11435907] Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7238-41 [1678519] Neuroscience. 1992 Dec;51(3):501-12 [1488111] J Neurosci. 1993 Mar;13(3):1080-7 [7680065] J Biol Chem. 1993 Mar 5;268(7):4637-42 [8383121] J Neurochem. 1993 Jun;60(6):2334-7 [8492136] J Neurosci. 1993 Dec;13(12):5402-6 [8254382] Neuroscience. 1994 Dec;63(3):765-73 [7898676] J Neurochem. 1996 Jul;67(1):374-81 [8667016] Eur J Pharmacol. 1996 Dec 5;316(2-3):325-31 [8982704] J Neurochem. 1997 Jul;69(1):315-21 [9202325] Trends Neurosci. 1997 Oct;20(10):482-7 [9347617] Eur J Pharmacol. 1998 Apr 24;347(2-3):153-8 [9653875] Pharmacol Ther. 1998 Dec;80(3):231-64 [9888696] Biochem Pharmacol. 1999 Sep 15;58(6):1035-45 [10509756] Trends Neurosci. 2004 Dec;27(12):735-43 [15541514] Pharmacol Ther. 2005 Jan;105(1):69-84 [15626456] J Neurochem. 2005 Feb;92(3):433-41 [15659214] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8746-51 [15937104] J Proteome Res. 2005 Jul-Aug;4(4):1397-402 [16083292] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - PAI-1, t-PA and circulating hTERT DNA as related to virus infection in liver carcinogenesis. AN - 70457084; 18383849 AB - Liver carcinogenesis seems to be heavely influenced by hepatitis B and C viral (HBV, HCV) infection. The aim of our study was to improve the detection of hepatocellular carcinoma (HCC) by measuring alfa-fetoprotein (AFP) in addition to other molecular markers by estimating the plasma levels of human catalytic fraction of reverse telomerase (hTERT) DNA, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) in 75 patients with liver desease. A control group was enrolled (N=30). PAI-1 and t-PA levels were detected with enzyme-linked immunoassorbent assay (ELISA), DNA hTERT was performed with real time polymerase chain reaction (RT-PCR). PAI-1, t-PA and hTERT DNA levels were much higher than in controls. PAI-1 and t-PA levels were higher in the presence of both viruses compared to their absence, p<0.001. Moreover, hTERT was significantly higher in the presence of both viruses, p<0.05 and in the presence of HCV alone, p<0.05. No decrease or increase of AFP was noted in these patients. Our data suggest the reliability of PAI-1, t-PA and hTERT in detecting HCC, in particular when the carcinogenesis is affected by virus infection. JF - Anticancer research AU - Divella, Rosa AU - Lacalamita, Rosanna AU - Tommasi, Stefania AU - Coviello, Maria AU - Daniele, Antonella AU - Garrisi, Vito Michele AU - Abbate, Ines AU - Simone, Giovanni AU - Gadaleta, Cosimo AU - Paradiso, Angelo AU - Quaranta, Michele AD - Chemical-Clinical Microbiology and Immunology Laboratory Unit, Giovanni Paolo II, National Cancer Institute, Bari, Italy. rosadive@inwind.it PY - 2008 SP - 223 EP - 228 VL - 28 IS - 1A SN - 0250-7005, 0250-7005 KW - DNA, Neoplasm KW - 0 KW - Plasminogen Activator Inhibitor 1 KW - SERPINE1 protein, human KW - alpha-Fetoproteins KW - TERT protein, human KW - EC 2.7.7.49 KW - Telomerase KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Aged KW - Middle Aged KW - alpha-Fetoproteins -- metabolism KW - Male KW - Female KW - DNA, Neoplasm -- blood KW - Cell Transformation, Neoplastic -- pathology KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Tissue Plasminogen Activator -- blood KW - Carcinoma, Hepatocellular -- blood KW - Plasminogen Activator Inhibitor 1 -- blood KW - Telomerase -- genetics KW - Liver Neoplasms -- blood KW - Cell Transformation, Neoplastic -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70457084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=PAI-1%2C+t-PA+and+circulating+hTERT+DNA+as+related+to+virus+infection+in+liver+carcinogenesis.&rft.au=Divella%2C+Rosa%3BLacalamita%2C+Rosanna%3BTommasi%2C+Stefania%3BCoviello%2C+Maria%3BDaniele%2C+Antonella%3BGarrisi%2C+Vito+Michele%3BAbbate%2C+Ines%3BSimone%2C+Giovanni%3BGadaleta%2C+Cosimo%3BParadiso%2C+Angelo%3BQuaranta%2C+Michele&rft.aulast=Divella&rft.aufirst=Rosa&rft.date=2008-01-01&rft.volume=28&rft.issue=1A&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-10 N1 - Date created - 2008-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The plasma proteome, adductome and idiosyncratic toxicity in toxicoproteomics research. AN - 70437249; 18270218 AB - Toxicoproteomics uses the discovery potential of proteomics in toxicology research by applying global protein measurement technologies to biofluids and tissues after host exposure to injurious agents. Toxicoproteomic studies thus far have focused on protein profiling of major organs and biofluids such as liver and blood in preclinical species exposed to model toxicants. The slow pace of discovery for new biomarkers, toxicity signatures and mechanistic insights is partially due to the limited proteome coverage derived from analysis of native organs, tissues and body fluids by traditional proteomic platforms. Improved toxicoproteomic analysis would result by combining higher data density LC-MS/MS platforms with stable isotope labelled peptides and parallel use of complementary platforms. Study designs that remove abundant proteins from biofluids, enrich subcellular structures and include cell specific isolation from heterogeneous tissues would greatly increase differential expression capabilities. By leveraging resources from immunology, cell biology and nutrition research communities, toxicoproteomics could make particular contributions in three inter-related areas to advance mechanistic insights and biomarker development: the plasma proteome and circulating microparticles, the adductome and idiosyncratic toxicity. JF - Briefings in functional genomics & proteomics AU - Merrick, B Alex AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. merrick@niehs.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 35 EP - 49 VL - 7 IS - 1 SN - 1473-9550, 1473-9550 KW - Biomarkers KW - 0 KW - Blood Proteins KW - Proteome KW - Index Medicus KW - Animals KW - Drug Hypersensitivity -- immunology KW - Humans KW - Biomarkers -- blood KW - Proteomics -- methods KW - Proteomics -- trends KW - Toxicology -- trends KW - Proteome -- metabolism KW - Toxicology -- methods KW - Blood Proteins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70437249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Briefings+in+functional+genomics+%26+proteomics&rft.atitle=The+plasma+proteome%2C+adductome+and+idiosyncratic+toxicity+in+toxicoproteomics+research.&rft.au=Merrick%2C+B+Alex&rft.aulast=Merrick&rft.aufirst=B&rft.date=2008-01-01&rft.volume=7&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Briefings+in+functional+genomics+%26+proteomics&rft.issn=14739550&rft_id=info:doi/10.1093%2Fbfgp%2Feln004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-10 N1 - Date created - 2008-03-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Bioanal Chem. 2004 Feb;378(4):1037-45 [14647945] J Biol Chem. 2004 Mar 12;279(11):10556-63 [14684732] Mol Cell Proteomics. 2004 Apr;3(4):311-26 [14718574] J Proteome Res. 2004 Mar-Apr;3(2):235-44 [15113099] Annu Rev Biophys Biomol Struct. 2004;33:297-316 [15139815] Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:122-30 [15209412] Curr Top Med Chem. 2004;4(13):1411-21 [15379654] Blood. 2004 Oct 15;104(8):2543-8 [15213101] Science. 2004 Oct 22;306(5696):640-3 [15499008] Biochem Pharmacol. 1990 Aug 1;40(3):573-9 [2200409] Clin Chem. 1994 Jul;40(7 Pt 2):1363-7 [8013120] J Biol Chem. 1997 Jul 4;272(27):17216-22 [9202045] Lancet. 2000 Jan 22;355(9200):308-11 [10675088] Transplantation. 2000 Jul 27;70(2):340-8 [10933161] J Biol Chem. 2001 Jul 6;276(27):25318-23 [11320098] Immunity. 2001 Nov;15(5):825-35 [11728343] Chem Res Toxicol. 1997 Oct;10(10):1097-103 [9348431] Biochemistry. 1999 Jun 22;38(25):8159-66 [10387061] J Chromatogr A. 2004 Oct 8;1051(1-2):3-17 [15532550] Nat Rev Genet. 2004 Dec;5(12):936-48 [15573125] Toxicol Pathol. 2004 Nov-Dec;32(6):619-42 [15580702] Toxicol Sci. 2005 Feb;83(2):282-92 [15342952] Curr Opin Mol Ther. 2004 Dec;6(6):600-7 [15663324] Curr Mol Med. 2005 Feb;5(1):39-52 [15720269] Physiol Genomics. 2005 Mar 21;21(1):92-104 [15781589] Trends Pharmacol Sci. 2005 Apr;26(4):202-9 [15808345] Environ Health Perspect. 2005 Jun;113(6):801-7 [15929907] IEEE Eng Med Biol Mag. 2005 May-Jun;24(3):34-40 [15971839] Curr Drug Metab. 2005 Jun;6(3):161-225 [15975040] Environ Health Perspect. 2005 Jul;113(7):840-8 [16002370] Nat Rev Mol Cell Biol. 2005 Jul;6(7):577-83 [15957003] J Proteome Res. 2005 Jul-Aug;4(4):1110-3 [16083260] J Biol Chem. 2005 Aug 19;280(33):29885-98 [15944157] Hepatology. 2005 Sep;42(3):665-74 [16116632] Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):189-94 [15992845] Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):195-9 [16002114] J Proteome Res. 2005 Sep-Oct;4(5):1516-21 [16212402] Biotechnol Annu Rev. 2005;11:1-68 [16216773] Curr Opin Chem Biol. 2007 Jun;11(3):293-9 [17574899] J Am Soc Mass Spectrom. 2007 Jul;18(7):1249-64 [17553692] Expert Rev Mol Diagn. 2007 Jul;7(4):371-93 [17620046] Epilepsia. 2007 Jul;48(7):1223-44 [17386054] Scand J Immunol. 2007 Aug-Sep;66(2-3):159-65 [17635793] Drug Metab Dispos. 2007 Aug;35(8):1408-17 [17510247] Exp Gerontol. 2007 Aug;42(8):798-806 [17587521] Toxicol Sci. 2007 Sep;99(1):326-37 [17562736] Circ Res. 2007 Aug 17;101(4):368-76 [17615369] Eur J Dermatol. 2007 Sep-Oct;17(5):422-7 [17673387] Bone. 2007 Oct;41(4):646-58 [17627911] Am J Physiol Renal Physiol. 2007 Oct;293(4):F994-F1006 [17581926] Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):689-704 [17916055] Toxicol Sci. 2007 Nov;100(1):156-67 [17698512] Expert Opin Drug Saf. 2007 Nov;6(6):673-84 [17967156] Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3673-84 [17921335] Curr Drug Metab. 2002 Aug;3(4):367-77 [12093356] Mol Cell Proteomics. 2002 Nov;1(11):845-67 [12488461] Toxicology. 2002 Dec 27;181-182:517-21 [12505361] Proteomics. 2003 Jul;3(7):1345-64 [12872236] Environ Health Perspect. 2003 Aug;111(11):A578-9 [12940285] Ann Intern Med. 2003 Sep 2;139(5 Pt 2):437-40 [12965972] Int J Hyg Environ Health. 2003 Aug;206(4-5):437-45 [12971699] Proteomics. 2005 Nov;5(16):4197-204 [16206326] Mol Diagn. 2005;9(3):119-27 [16271013] Springer Semin Immunopathol. 2005 Nov;27(3):375-87 [16189651] Proteomics. 2005 Nov;5(17):4398-413 [16222722] J Proteome Res. 2006 Jan;5(1):112-21 [16396501] Chem Res Toxicol. 2006 Jan;19(1):20-9 [16411652] Endocrinology. 2006 Feb;147(2):714-23 [16269464] Proteomics. 2006 Feb;6(3):972-82 [16453347] J Lab Clin Med. 2006 Mar;147(3):126-32 [16503242] Mol Cell Proteomics. 2006 Apr;5(4):573-88 [16332733] Physiol Genomics. 2006 Apr 13;25(2):203-15 [16403844] Biotechnol Appl Biochem. 2006 Jun;44(Pt 3):119-28 [16704375] Trends Microbiol. 2006 May;14(5):229-35 [16603360] J Proteome Res. 2006 Jun;5(6):1379-87 [16739989] J Am Diet Assoc. 2006 Jul;106(7):1074-81; quiz 1083 [16815124] J Pharmacol Exp Ther. 2006 Aug;318(2):792-802 [16687475] Kidney Int. 2006 Aug;70(3):496-506 [16760904] Chem Res Toxicol. 2006 Aug;19(8):986-98 [16918237] Expert Opin Drug Metab Toxicol. 2005 Aug;1(2):247-60 [16922640] Drug Metab Rev. 2006;38(4):641-9 [17145693] Methods. 2007 Jan;41(1):112-7 [17161307] Biochim Biophys Acta. 2006 Dec;1764(12):1823-41 [17070740] Methods Mol Biol. 2007;367:87-119 [17185772] Annu Rev Pharmacol Toxicol. 2007;47:513-39 [16879083] Br J Clin Pharmacol. 2007 Feb;63(2):249-51 [16939530] Expert Rev Proteomics. 2007 Feb;4(1):107-19 [17288519] Chem Res Toxicol. 2007 Feb;20(2):227-34 [17305406] FEBS Lett. 2007 Mar 6;581(5):795-9 [17289032] Life Sci. 2007 Mar 20;80(15):1345-54 [17210164] Chem Res Toxicol. 2007 Mar;20(3):511-9 [17305373] BMC Bioinformatics. 2007;8:95 [17367530] Blood Rev. 2007 May;21(3):157-71 [17118501] Int J Hyg Environ Health. 2007 May;210(3-4):201-28 [17376741] Toxicol Sci. 2007 May;97(1):205-13 [17150972] Science. 2007 May 4;316(5825):695-6 [17478705] Toxicol Sci. 2007 Jul;98(1):240-8 [17449896] Chem Res Toxicol. 2007 Jun;20(6):859-67 [17480101] Ann Nutr Metab. 2007;51(2):99-107 [17476098] Toxicol Sci. 2003 Oct;75(2):236-48 [12883082] Proteomics. 2004 Feb;4(2):490-1 [14760721] J Biochem Mol Biol. 2004 Jan 31;37(1):59-74 [14761304] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/bfgp/eln004 ER - TY - JOUR T1 - Physical activity and cancer prevention : pathways and targets for intervention. AN - 70422848; 18348589 AB - The prevalence of obesity, an established epidemiological risk factor for many cancers, has risen steadily for the past several decades in the US and many other countries. Particularly alarming are the increasing rates of obesity among children, portending continuing increases in the rates of obesity and obesity-related cancers for many years to come. Modulation of energy balance, via increased physical activity, has been shown in numerous comprehensive epidemiological reviews to reduce cancer risk. Unfortunately, the effects and mechanistic targets of physical activity interventions on the carcinogenesis process have not been thoroughly characterized. Studies to date suggest that exercise can exert its cancer-preventive effects at many stages during the process of carcinogenesis, including both tumour initiation and progression. As discussed in this review, exercise may be altering tumour initiation events by modifying carcinogen activation, specifically by enhancing the cytochrome P450 system and by enhancing selective enzymes in the carcinogen detoxification pathway, including, but not limited to, glutathione-S-transferases. Furthermore, exercise may reduce oxidative damage by increasing a variety of anti-oxidant enzymes, enhancing DNA repair systems and improving intracellular protein repair systems. In addition to altering processes related to tumour initiation, exercise may also exert a cancer-preventive effect by dampening the processes involved in the promotion and progression stages of carcinogenesis, including scavenging reactive oxygen species (ROS); altering cell proliferation, apoptosis and differentiation; decreasing inflammation; enhancing immune function; and suppressing angiogenesis. A paucity of data exists as to whether exercise may be working as an anti-promotion strategy via altering ROS in initiated or preneoplastic models; therefore, no conclusions can be made about this possible mechanism. The studies directly examining cell proliferation and apoptosis have shown that exercise can enhance both processes, which is difficult to interpret in the context of carcinogenesis. Studies examining the relationship between exercise and chronic inflammation suggest that exercise may reduce pro-inflammatory mediators and reduce the state of low-grade, chronic inflammation. Additionally, exercise has been shown to enhance components of the innate immune response (i.e. macrophage and natural killer cell function). Finally, only a limited number of studies have explored the relationship between exercise and angiogenesis; therefore, no conclusions can be made currently about the role of exercise in the angiogenesis process as it relates to tumour progression. In summary, exercise can alter biological processes that contribute to both anti-initiation and anti-progression events in the carcinogenesis process. However, more sophisticated, detailed studies are needed to examine each of the potential mechanisms contributing to an exercise-induced decrease in carcinogenesis in order to determine the minimum dose, duration and frequency of exercise needed to yield significant cancer-preventive effects, and whether exercise can be used prescriptively to reverse the obesity-induced physiological changes that increase cancer risk. JF - Sports medicine (Auckland, N.Z.) AU - Rogers, Connie J AU - Colbert, Lisa H AU - Greiner, John W AU - Perkins, Susan N AU - Hursting, Stephen D AD - Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 271 EP - 296 VL - 38 IS - 4 SN - 0112-1642, 0112-1642 KW - Index Medicus KW - Risk Factors KW - Humans KW - Exercise -- physiology KW - Neoplasms -- prevention & control KW - Motor Activity -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70422848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sports+medicine+%28Auckland%2C+N.Z.%29&rft.atitle=Physical+activity+and+cancer+prevention+%3A+pathways+and+targets+for+intervention.&rft.au=Rogers%2C+Connie+J%3BColbert%2C+Lisa+H%3BGreiner%2C+John+W%3BPerkins%2C+Susan+N%3BHursting%2C+Stephen+D&rft.aulast=Rogers&rft.aufirst=Connie&rft.date=2008-01-01&rft.volume=38&rft.issue=4&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Sports+medicine+%28Auckland%2C+N.Z.%29&rft.issn=01121642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-19 N1 - Date created - 2008-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Internet resources integrating many small-molecule databases. AN - 70359712; 18311630 AB - ()New data, tools and services recently made available on the web server (http://cactus.nci.nih.gov) of the Computer-Aided Drug Design (CADD) Group, NCI, NIH, developed in the context of chemoinformatics and drug development work, are presented. These tools are designed for searching for structures in very large databases of small molecules. One of them is a web service-the Chemical Structure Look-up Service (CSLS)-for very rapid structure look-up in an aggregated collection of more than 80 databases comprising more than 27 million unique structures at the time of this writing. CSLS contains pointers to the entries in toxicology-related databases, catalogues of commercially available samples, drugs, assay results data sets, and databases in several other categories. CSLS allows the user to find out very rapidly in which one(s) of all these databases a given structure occurs independent of the representation of the input structure, by making use of InChIs as well as new CACTVS hashcode-based identifiers. These latter, calculable, identifiers are designed to take into account tautomerism, different resonance structures drawn for charged species, and presence of additional fragments. They make possible fine-tunable yet rapid compound identification and database overlap analyses in very large compound collections. JF - SAR and QSAR in environmental research AU - Sitzmann, M AU - Filippov, I V AU - Nicklaus, M C AD - Computer-Aided Drug Design Group, Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS, Frederick, MD, USA. PY - 2008 SP - 1 EP - 9 VL - 19 IS - 1-2 SN - 1062-936X, 1062-936X KW - Index Medicus KW - Molecular Structure KW - Computer-Aided Design KW - Internet KW - Databases, Factual KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70359712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SAR+and+QSAR+in+environmental+research&rft.atitle=Internet+resources+integrating+many+small-molecule+databases.&rft.au=Sitzmann%2C+M%3BFilippov%2C+I+V%3BNicklaus%2C+M+C&rft.aulast=Sitzmann&rft.aufirst=M&rft.date=2008-01-01&rft.volume=19&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=SAR+and+QSAR+in+environmental+research&rft.issn=1062936X&rft_id=info:doi/10.1080%2F10629360701843540 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-26 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10629360701843540 ER - TY - JOUR T1 - The role of telomere biology in bone marrow failure and other disorders. AN - 70356210; 18160098 AB - Telomeres, consisting of nucleotide repeats and a protein complex at chromosome ends, are essential in maintaining chromosomal integrity. Dyskeratosis congenita (DC) is the inherited bone marrow failure syndrome (IBMFS) that epitomizes the effects of abnormal telomere biology. Patients with DC have extremely short telomere lengths (<1st percentile) and many have mutations in telomere biology genes. Interpretation of telomere length in other IBMFSs is less straightforward. Abnormal telomere shortening has been reported in patients with apparently acquired hematologic disorders, including aplastic anemia, myeolodysplasia, paroxysmal nocturnal hemoglobinuria, and leukemia. In these disorders, the shortest-lived cells have the shortest telomeres, suggestive of increased hematopoietic stress. Telomeres are also markers of replicative and/or oxidative stress in other complex disease pathways, such as inflammation, stress, and carcinogenesis. The spectrum of related disorders caused by mutations in telomere biology genes extends beyond classical DC to include marrow failure that does not respond to immunosuppression, idiopathic pulmonary fibrosis, and possibly other syndromes. We suggest that such patients be categorized as having an inherited disorder of telomere biology. Longitudinal studies of patients with very short telomeres but without classical DC are necessary to further understand the long-term sequelae, such as malignancy, osteonecrosis/osteoporosis, and pulmonary and liver disease. JF - Mechanisms of ageing and development AU - Savage, Sharon A AU - Alter, Blanche P AD - Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, United States. savagesh@mail.nih.gov PY - 2008 SP - 35 EP - 47 VL - 129 IS - 1-2 SN - 0047-6374, 0047-6374 KW - Index Medicus KW - Hematologic Diseases -- genetics KW - Syndrome KW - Humans KW - Dyskeratosis Congenita -- genetics KW - Mutation KW - Inheritance Patterns KW - Anemia, Aplastic -- genetics KW - Telomere -- metabolism KW - Telomere -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70356210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+ageing+and+development&rft.atitle=The+role+of+telomere+biology+in+bone+marrow+failure+and+other+disorders.&rft.au=Savage%2C+Sharon+A%3BAlter%2C+Blanche+P&rft.aulast=Savage&rft.aufirst=Sharon&rft.date=2008-01-01&rft.volume=129&rft.issue=1-2&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+ageing+and+development&rft.issn=00476374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-03 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Haematol. 1999 Jun;105(4):883-93 [10554797] Br J Haematol. 1999 Jun;105(4):997-1001 [10554813] Nature. 1999 Dec 2;402(6761):551-5 [10591218] Blood. 2000 Mar 15;95(6):1883-90 [10706851] Bone Marrow Transplant. 2000 Feb;25(4):441-7 [10723589] Blood. 2001 Jan 15;97(2):575-7 [11154240] J Pediatr Hematol Oncol. 2001 Jan;23(1):39-44 [11196268] Blood. 2001 Feb 15;97(4):895-900 [11159514] Hum Mol Genet. 2001 Apr;10(7):677-85 [11257099] Blood Cells Mol Dis. 2001 Mar-Apr;27(2):353-7 [11259155] Br J Haematol. 2001 Mar;112(4):1025-30 [11298602] Ann N Y Acad Sci. 2001 Jun;938:1-7; discussion 7-8 [11458496] Ann N Y Acad Sci. 2001 Jun;938:293-303; discussion 303-4 [11458518] Cytogenet Cell Genet. 2001;93(3-4):203-6 [11528113] Bone Marrow Transplant. 2001 Jun;27(12):1283-6 [11548846] FEBS Lett. 2001 Sep 28;506(1):22-6 [11591364] Exp Gerontol. 2002 Apr;37(4):523-31 [11830355] Br J Haematol. 2002 Feb;116(2):491-6 [11841457] Oncogene. 2002 Jan 21;21(4):564-79 [11850781] Oncogene. 2002 Jan 21;21(4):598-610 [11850785] Hum Mol Genet. 2002 Feb 15;11(4):439-44 [11854176] N Engl J Med. 1994 Jan 27;330(4):249-55 [8272086] EMBO J. 1994 Jan 1;13(1):110-7 [8306954] Am J Med Genet. 1994 Feb 15;49(4):374-7 [8160728] Cancer Res. 1994 Jul 1;54(13):3557-60 [8012981] Am J Hum Genet. 1994 Nov;55(5):876-82 [7977349] Bone Marrow Transplant. 1997 Feb;19(4):389-92 [9051251] Cancer. 1997 Apr 15;79(8):1552-60 [9118038] Eur J Hum Genet. 1997 May-Jun;5(3):137-48 [9272737] Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13782-5 [9391104] Leukemia. 1998 Jan;12(1):13-24 [9436916] Lancet. 1998 Jan 17;351(9097):178-81 [9449873] Cell. 1998 Mar 6;92(5):587-90 [9506510] Blood. 1998 May 15;91(10):3582-92 [9572992] Proc Natl Acad Sci U S A. 1998 May 12;95(10):5607-10 [9576930] Nat Genet. 1998 May;19(1):32-8 [9590285] Nat Biotechnol. 1998 Aug;16(8):743-7 [9702772] Immunity. 1998 Aug;9(2):151-7 [9729035] Nat Genet. 1999 Feb;21(2):169-75 [9988267] Blood. 1999 May 1;93(9):2824-30 [10216076] Clin Cancer Res. 1999 May;5(5):1155-60 [10353751] J Exp Med. 1999 Jul 19;190(2):157-67 [10432279] Blood. 2004 Dec 1;104(12):3588-90 [15284109] J Mammary Gland Biol Neoplasia. 2004 Jul;9(3):285-96 [15557801] Am J Hum Genet. 2005 Jan;76(1):147-51 [15520935] Blood. 2004 Dec 15;104(13):3927-35 [15319283] Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5 [15574496] Leuk Lymphoma. 2005 Mar;46(3):393-9 [15621829] Annu Rev Med. 2005;56:1-16 [15660498] Leukemia. 2005 Feb;19(2):296-8 [15549144] Haematologica. 2005 Mar;90(3):307-16 [15749662] N Engl J Med. 2005 Apr 7;352(14):1413-24 [15814878] Blood. 2006 Oct 15;108(8):2509-19 [16778145] Hematology Am Soc Hematol Educ Program. 2006;:24-8, 516 [17124035] Hematology Am Soc Hematol Educ Program. 2006;:63-71 [17124042] Hematology Am Soc Hematol Educ Program. 2006;:72-7 [17124043] Am J Epidemiol. 2007 Jan 1;165(1):14-21 [17043079] Am J Hum Genet. 2006 Dec;79(6):1110-8 [17186470] Lancet. 2007 Jan 13;369(9556):107-14 [17223473] Biol Blood Marrow Transplant. 2007 Mar;13(3):366-8 [17317590] Exp Hematol. 2007 Apr;35(4):673-81 [17379077] N Engl J Med. 2007 Mar 29;356(13):1317-26 [17392301] Nat Protoc. 2006;1(5):2365-76 [17406480] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9 [17416776] Pediatr Hematol Oncol. 2007 Mar;24(2):87-99 [17454774] Proc Natl Acad Sci U S A. 2007 May 1;104(18):7552-7 [17460043] Haematologica. 2007 Aug;92(8):1013-20 [17640862] Pediatr Transplant. 2007 Sep;11(6):584-94 [17663679] Blood. 2007 Aug 15;110(4):1141-6 [17478638] Stem Cells. 2007 Aug;25(8):1853-61 [17510216] Blood. 2007 Sep 1;110(5):1439-47 [17468339] J Immunol. 2007 Sep 15;179(6):4249-54 [17785865] Aging Cell. 2007 Oct;6(5):639-47 [17874998] Hum Mutat. 2007 Dec;28(12):1178-82 [17647292] Exp Hematol. 2007 Dec;35(12):1777-81 [17697745] Am J Hum Genet. 2008 Feb;82(2):501-9 [18252230] Br J Haematol. 2002 Apr;117(1):189-92 [11918553] Acta Haematol. 2002;107(4):208-12 [12053148] Science. 2002 Jul 26;297(5581):565-9 [12142527] J Pediatr. 2002 Aug;141(2):259-65 [12183724] J Pediatr. 2002 Aug;141(2):266-70 [12183725] Pediatr Res. 2002 Sep;52(3):377-81 [12193671] Nat Genet. 2002 Oct;32(2):280-4 [12355086] Ann Hematol. 2002 Oct;81(10):566-9 [12424537] Cancer Res. 2002 Nov 15;62(22):6405-9 [12438224] Blood. 2003 Jan 1;101(1):358-62 [12393549] Blood. 2003 Jan 1;101(1):375-6 [12485943] Leukemia. 2003 Feb;17(2):401-10 [12592340] Br J Haematol. 2003 Mar;120(5):836-45 [12614219] Bone Marrow Transplant. 2003 May;31(10):847-50 [12748659] Blood. 2003 Jul 15;102(2):514-6 [12623835] Blood. 2003 Aug 1;102(3):916-8 [12676774] J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8 [12928346] Cytometry A. 2003 Sep;55(1):1-6 [12938182] Hum Immunol. 2003 Sep;64(9):896-901 [12941546] Eur J Pediatr. 2003 Dec;162(12):863-7 [14648217] Lancet. 2004 Feb 14;363(9408):507-10 [14975611] Acta Haematol. 2004;111(3):125-31 [15034232] Nat Genet. 2004 May;36(5):447-9 [15098033] Clin Cancer Res. 2004 May 15;10(10):3317-26 [15161685] Br J Haematol. 2004 Jul;126(1):63-71 [15198733] Hepatology. 2004 Jul;40(1):80-6 [15239089] Leuk Res. 2004 Oct;28(10):1001-4 [15289009] Leuk Res. 2004 Oct;28(10):1013-21 [15289012] Br J Haematol. 2004 Sep;126(5):682-5 [15327519] Br J Haematol. 2004 Oct;127(1):105-13 [15384984] Eur J Haematol. 2004 Nov;73(5):351-8 [15458514] J Med Genet. 1992 Sep;29(9):673-5 [1404302] Am J Pediatr Hematol Oncol. 1992 Nov;14(4):297-304 [1456394] Leukemia. 2005 Apr;19(4):644-51 [15716989] Biochem Biophys Res Commun. 2005 Jun 10;331(3):881-90 [15865944] Blood Cells Mol Dis. 2005 May-Jun;34(3):257-63 [15885610] Curr Opin Genet Dev. 2005 Jun;15(3):249-57 [15917199] Exp Gerontol. 2005 May;40(5):363-8 [15919587] Carcinogenesis. 2005 Jul;26(7):1263-71 [15746160] Blood. 2005 Jul 15;106(2):531-3 [15811960] Semin Oncol. 2005 Aug;32(4 Suppl 5):S3-10 [16085011] Lancet. 2005 Aug 20-26;366(9486):662-4 [16112303] Leuk Res. 2005 Oct;29(10):1131-9 [16111531] Genes Dev. 2005 Sep 15;19(18):2100-10 [16166375] J Clin Oncol. 2005 Sep 20;23(27):6699-711 [16170178] Int J Hematol. 2005 Oct;82(3):184-9 [16207588] Twin Res Hum Genet. 2005 Oct;8(5):433-9 [16212832] Transplantation. 2005 Oct 15;80(7):969-76 [16249747] Hematology Am Soc Hematol Educ Program. 2005;:96-103 [16304365] Bone Marrow Transplant. 2005 Dec;36(12):1103-5; author reply 1105 [16205731] J Cell Mol Med. 2005 Oct-Dec;9(4):977-89 [16364206] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9203-8 [10922071] Hypertension. 2000 Aug;36(2):195-200 [10948077] Blood. 2000 Dec 1;96(12):3991-4 [11090091] Psychoneuroendocrinology. 2006 Apr;31(3):277-87 [16298085] Hum Genet. 2006 Apr;119(3):344-50 [16440201] Blood. 2006 Apr 1;107(7):2680-5 [16332973] Exp Hematol. 2006 May;34(5):664-71 [16647572] Int J Hematol. 2006 Apr;83(3):275-6 [16720563] Transfusion. 2006 Jun;46(6):1038-43 [16734822] Curr Opin Hematol. 2006 Jul;13(4):266-72 [16755224] Curr Pharm Biotechnol. 2006 Jun;7(3):171-83 [16789902] Semin Hematol. 2006 Jul;43(3):167-77 [16822459] Semin Hematol. 2006 Jul;43(3):178-88 [16822460] Blood Cells Mol Dis. 2006 Sep-Oct;37(2):134-6 [16934504] Aging Cell. 2006 Oct;5(5):361-5 [16856882] Cancer Res. 2007 Jun 1;67(11):5538-44 [17545637] Hum Mol Genet. 2007 Jul 1;16(13):1619-29 [17507419] J Nippon Med Sch. 2007 Jun;74(3):202-9 [17625368] Biochem Biophys Res Commun. 2006 Mar 3;341(1):128-31 [16412982] J Clin Endocrinol Metab. 2006 Feb;91(2):635-40 [16303830] Am J Hum Genet. 2006 Mar;78(3):480-6 [16400618] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Violent behavior and DSM-IV psychiatric disorders: results from the national epidemiologic survey on alcohol and related conditions. AN - 70351342; 18312033 AB - To present nationally representative data on the lifetime prevalence and population estimates of violent behavior among individuals with DSM-IV psychiatric disorders. The data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions. Prevalences, population estimates, and associations of violent behavior occurring among individuals with pure, comorbid, and specific DSM-IV psychiatric disorders were examined. After controlling for sociodemographic characteristics and other comorbidity, it was found that the odds of violent behavior were significantly increased (p < .05) among individuals with substance use disorders; pathological gambling; major depressive disorder; bipolar disorders; panic disorder without agoraphobia; specific phobia; and paranoid, schizoid, histrionic, and obsessive-compulsive personality disorders. Percentages of violent behavior among individuals with each comorbid disorder were, with few exceptions, significantly greater (p < .05-p < .001) than the corresponding percentages among those presenting with the pure form of each disorder. Alcohol and drug use disorders were the most significant contributors to the public health burden of violent behavior. The majority of individuals with psychiatric disorders do not engage in violent behavior, and public perception associated with stereotypic violence among individuals with psychiatric disorders appears unwarranted. Elevated risks and burden of violent behavior were not equally shared across the spectrum of psychiatric disorders, with particular disorders, especially substance use disorders, contributing disproportionately to the burden. Future research should examine the circumstances under which violence among individuals with psychiatric disorders occurs with a view toward improving clinical prediction and developing more effective prevention strategies. JF - The Journal of clinical psychiatry AU - Pulay, Attila J AU - Dawson, Deborah A AU - Hasin, Deborah S AU - Goldstein, Risë B AU - Ruan, W June AU - Pickering, Roger P AU - Huang, Boji AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, Md. 20892-9304, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 12 EP - 22 VL - 69 IS - 1 KW - Index Medicus KW - Severity of Illness Index KW - Age Factors KW - Alcoholism -- diagnosis KW - Humans KW - Alcoholism -- psychology KW - Ethnic Groups -- psychology KW - Ethnic Groups -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Adult KW - Surveys and Questionnaires KW - Incidence KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Violence -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- psychology KW - Violence -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70351342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Violent+behavior+and+DSM-IV+psychiatric+disorders%3A+results+from+the+national+epidemiologic+survey+on+alcohol+and+related+conditions.&rft.au=Pulay%2C+Attila+J%3BDawson%2C+Deborah+A%3BHasin%2C+Deborah+S%3BGoldstein%2C+Ris%C3%AB+B%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BHuang%2C+Boji%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Pulay&rft.aufirst=Attila&rft.date=2008-01-01&rft.volume=69&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=1555-2101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-03-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Subst Abuse. 1997;9:127-35 [9494944] Am J Psychiatry. 1998 Feb;155(2):226-31 [9464202] Eur Addict Res. 1998 Dec;4(4):144-9 [9852366] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S1-6 [9857773] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S13-23 [9857775] Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S55-60 [9857780] Alcohol Clin Exp Res. 1999 Jan;23(1):144-50 [10029216] Arch Gen Psychiatry. 2004 Nov;61(11):1107-15 [15520358] J Consult Clin Psychol. 2004 Dec;72(6):1114-21 [15612857] J Clin Psychiatry. 2005 May;66(5):564-74 [15889941] J Clin Psychiatry. 2005 Jun;66(6):677-85 [15960559] J Subst Abuse Treat. 2005 Jul;29(1):5-17 [15979527] Psychiatry Res. 2005 Sep 15;136(2-3):153-62 [16125786] Arch Gen Psychiatry. 2005 Oct;62(10):1097-106 [16203955] J Clin Psychiatry. 2005 Oct;66(10):1205-15 [16259532] Psychol Med. 2005 Dec;35(12):1747-59 [16202187] J Clin Psychiatry. 2005 Nov;66(11):1351-61 [16420070] J Clin Psychiatry. 2006 Mar;67(3):363-74 [16649821] Am J Epidemiol. 2006 Dec 15;164(12):1199-208 [17032695] Arch Gen Psychiatry. 2007 May;64(5):566-76 [17485608] Arch Gen Psychiatry. 2007 Jul;64(7):830-42 [17606817] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] Addiction. 1999 Jun;94(6):843-55 [10665074] Am J Drug Alcohol Abuse. 2000 May;26(2):161-77 [10852354] Arch Gen Psychiatry. 2000 Oct;57(10):979-86 [11015816] Alcohol Res Health. 2001;25(1):58-65 [11496968] Alcohol Clin Exp Res. 2003 Feb;27(2):244-52 [12605073] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Clin Psychiatry. 2004 Jul;65(7):948-58 [15291684] Acta Psychiatr Scand Suppl. 2004;(424):5-59 [15447785] J Psychiatr Res. 2005 Jan;39(1):1-9 [15504418] Hosp Community Psychiatry. 1990 Jul;41(7):761-70 [2142118] Am J Psychiatry. 1990 Nov;147(11):1537-41 [2221170] Arch Gen Psychiatry. 1994 Mar;51(3):225-45 [8122959] Addiction. 1994 May;89(5):573-9 [8044123] J Consult Clin Psychol. 1995 Apr;63(2):256-62 [7751486] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Epidemiol Rev. 1995;17(1):172-81 [8521935] Drug Alcohol Depend. 1997 Mar 14;44(2-3):133-41 [9088785] Psychiatry. 1997 Spring;60(1):1-22 [9130311] Drug Alcohol Depend. 1997 Sep 25;47(3):161-9 [9306042] Drug Alcohol Depend. 1997 Sep 25;47(3):171-85 [9306043] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] Drug Alcohol Depend. 1997 Sep 25;47(3):217-26 [9306047] Arch Gen Psychiatry. 1998 May;55(5):393-401 [9596041] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determining the cellular targets of reactive oxygen species in Borrelia burgdorferi. AN - 70319789; 18287759 AB - The response of Borrelia burgdorferi to the challenge of reactive oxygen species (ROS) is a direct result of its limited biosynthetic capabilities and lack of biologically significant levels of intracellular Fe. In other bacteria, the major target for oxidative damage is DNA as a consequence of the reaction of "free" intracellular with ROS through the Fenton reaction. Therefore, cellular defenses in these bacteria are focused on protecting this essential cellular component. This does not seem to be the case for B. burgdorferi. In this chapter, we describe methods that were used to analyze the potential targets for ROS in B. burgdorferi. Surprisingly, membrane lipids (e.g., linoleic and linolenic acids) derived from host are the major target of ROS in the Lyme disease spirochete. JF - Methods in molecular biology (Clifton, N.J.) AU - Boylan, Julie A AU - Gherardini, Frank C AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratoties, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 213 EP - 221 VL - 431 SN - 1064-3745, 1064-3745 KW - DNA, Bacterial KW - 0 KW - Oxidants KW - Reactive Oxygen Species KW - Index Medicus KW - Microscopy, Fluorescence KW - Oxidants -- chemistry KW - Oxidants -- toxicity KW - Oxidants -- metabolism KW - Chromatography, High Pressure Liquid KW - Reactive Oxygen Species -- metabolism KW - DNA, Bacterial -- chemistry KW - DNA Damage KW - DNA, Bacterial -- genetics KW - Reactive Oxygen Species -- chemistry KW - DNA, Bacterial -- metabolism KW - Borrelia burgdorferi -- metabolism KW - Borrelia burgdorferi -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70319789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Determining+the+cellular+targets+of+reactive+oxygen+species+in+Borrelia+burgdorferi.&rft.au=Boylan%2C+Julie+A%3BGherardini%2C+Frank+C&rft.aulast=Boylan&rft.aufirst=Julie&rft.date=2008-01-01&rft.volume=431&rft.issue=&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-02 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transposon mutagenesis of the lyme disease agent Borrelia burgdorferi. AN - 70317429; 18287749 AB - Borrelia burgdorferi, the causative agent of Lyme disease, is an obligate parasite that cycles between vertebrate hosts and tick vectors. Attempts to understand the genetic factors that allow B. burgdorferi to sense, adapt to, and survive in different environments have been limited by a relatively low transformation rate. Here, we describe a mariner-based transposon system that achieves saturating levels of random mutagenesis in B. burgdorferi. In comparison with allelic exchange, which targets a single locus, transposon mutagenesis can create libraries of mutants encompassing disruptions of all genes. Suitably designed screens or selections of such a library permit the recovery of mutants exhibiting a desired phenotype. The system described here allows rapid identification of the genetic locus responsible for the mutant phenotype. With appropriate modifications, this mariner-based transposon can be adapted to other spirochetes and bacteria with inefficient genetic transformation methods. JF - Methods in molecular biology (Clifton, N.J.) AU - Stewart, Philip E AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 85 EP - 95 VL - 431 SN - 1064-3745, 1064-3745 KW - Retroelements KW - 0 KW - Index Medicus KW - Borrelia burgdorferi -- genetics KW - Retroelements -- genetics KW - Lyme Disease -- microbiology KW - Mutagenesis, Insertional -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70317429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Transposon+mutagenesis+of+the+lyme+disease+agent+Borrelia+burgdorferi.&rft.au=Stewart%2C+Philip+E%3BRosa%2C+Patricia+A&rft.aulast=Stewart&rft.aufirst=Philip&rft.date=2008-01-01&rft.volume=431&rft.issue=&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-02 N1 - Date created - 2008-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The potential utility of HPV genotyping in screening and clinical management. AN - 70285584; 18267061 AB - Detection of specific human papillomavirus (HPV) genotypes, or HPV genotyping, may be useful for differentiating between those women who are carcinogenic HPV-positive at lower and higher risk for cervical precancer and cancer. Considerable evidence already exists that the absolute risk for cervical precancer and cancer varies considerably among specific HPV genotypes, and that detection of HPV-16 and -18 may have clinical usefulness, especially among women who tested positive for carcinogenic HPV and have negative cytology. Detection of persistent carcinogenic HPV is strongly associated with cervical precancer and cancer and strongly predicts its development, and might be used to monitor the outcomes of HPV infections. However, several practical considerations must be addressed before HPV genotyping can be used in screening and clinical management. JF - Journal of the National Comprehensive Cancer Network : JNCCN AU - Castle, Philip E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Room 5004, EPS MSC 7234, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 83 EP - 95 VL - 6 IS - 1 SN - 1540-1405, 1540-1405 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Genotype KW - Mass Screening KW - DNA, Viral -- analysis KW - Humans KW - Decision Trees KW - Female KW - Uterine Cervical Neoplasms -- therapy KW - Cervical Intraepithelial Neoplasia -- pathology KW - Papillomavirus Infections -- diagnosis KW - Papillomavirus Infections -- virology KW - Uterine Cervical Neoplasms -- diagnosis KW - Papillomavirus Infections -- pathology KW - Cervical Intraepithelial Neoplasia -- therapy KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- therapy KW - Cervical Intraepithelial Neoplasia -- virology KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70285584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Comprehensive+Cancer+Network+%3A+JNCCN&rft.atitle=The+potential+utility+of+HPV+genotyping+in+screening+and+clinical+management.&rft.au=Castle%2C+Philip+E&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-01-01&rft.volume=6&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Comprehensive+Cancer+Network+%3A+JNCCN&rft.issn=15401405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China. AN - 70247730; 17984110 AB - Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER genes-x-ray repair cross-complementing group 1 (XRCC1) (R194W, rs1799782; R280H, rs25489 and R399Q, rs25487), apurinic/apyrimidinic endonuclease (APEX1) (D148E, rs3136820) and 8-oxoguanine DNA glycosylase (OGG1) (S326C, rs1052133), in a population-based study of 411 biliary tract cancer cases (237 gallbladder, 127 bile duct and 47 ampulla of Vater), 891 biliary (gallbladder or bile duct) stone cases and 786 population controls conducted in Shanghai, China. Compared with subjects carrying the XRCC1 194RR genotype, those with the WW genotype had a 1.9-fold risk of bile duct cancer [odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.5, P(trend) = 0.03], and compared with subjects carrying the XRCC1 280RR genotype, those with the XRCC1 280H allele had a 50% reduced risk of bile duct cancer (OR = 0.5, 95% CI = 0.3-0.9, P(trend) = 0.05). The effect of the R280H polymorphism persisted (P(trend) = 0.03), when all three XRCC1 polymorphisms were jointly considered in the model, a finding supported by the haplotype results (covariate-adjusted global permutation P = 0.03). We also found an inverse association between the APEX1 148E allele and gallbladder stones (P(trend) = 0.03), but no association for the OGG1 polymorphism. This study suggests that genetic variants in XRCC1 and APEX1 may alter susceptibility to biliary tract cancer and stones. Further studies are required to confirm the reported associations. JF - Carcinogenesis AU - Huang, Wen-Yi AU - Gao, Yu-Tang AU - Rashid, Asif AU - Sakoda, Lori C AU - Deng, Jie AU - Shen, Ming-Chang AU - Wang, Bin-Sheng AU - Han, Tian-Quan AU - Zhang, Bai-He AU - Chen, Bingshu E AU - Rosenberg, Philip S AU - Chanock, Stephen J AU - Hsing, Ann W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 100 EP - 105 VL - 29 IS - 1 KW - Index Medicus KW - Genotype KW - Humans KW - China -- epidemiology KW - Case-Control Studies KW - DNA Repair -- genetics KW - Gallstones -- epidemiology KW - Biliary Tract Neoplasms -- epidemiology KW - Polymorphism, Genetic KW - Biliary Tract Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Gallstones -- genetics KW - Population Surveillance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70247730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Selected+base+excision+repair+gene+polymorphisms+and+susceptibility+to+biliary+tract+cancer+and+biliary+stones%3A+a+population-based+case-control+study+in+China.&rft.au=Huang%2C+Wen-Yi%3BGao%2C+Yu-Tang%3BRashid%2C+Asif%3BSakoda%2C+Lori+C%3BDeng%2C+Jie%3BShen%2C+Ming-Chang%3BWang%2C+Bin-Sheng%3BHan%2C+Tian-Quan%3BZhang%2C+Bai-He%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BChanock%2C+Stephen+J%3BHsing%2C+Ann+W&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2008-01-01&rft.volume=29&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-31 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intersection of nuclear receptors and the proteasome on the epigenetic landscape. AN - 70222873; 18095329 AB - Nuclear receptors (NRs) represent a class of transcription factors that associate with both positive and negative chromatin modifying complexes to activate or repress gene transcription. The 26S proteasome plays a major role in NR-regulated gene transcription by tightly regulating the levels of the receptor and coregulator complexes. Recent evidence suggests a robust nonproteolytic role for specific proteasome subunits in gene transcription mediated via alterations in specific histone modifications. The involvement of nuclear receptors and the proteasome with chromatin modifying complexes or proteins, particularly those that modify DNA and histone proteins, provides an opportunity to review two critical epigenetic mechanisms that control gene expression and heritable biological processes. Both nuclear receptors and the proteasome are targets of environmental factors including some which lead to epigenetic changes that can influence human diseases such as cancer. In this review, we will explore molecular mechanisms by which NR-mediated gene expression, under the control of the proteasome, can result in altered epigenetic landscapes. JF - Environmental and molecular mutagenesis AU - Kinyamu, H Karimi AU - Jefferson, Wendy N AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 83 EP - 95 VL - 49 IS - 1 SN - 0893-6692, 0893-6692 KW - Receptors, Cytoplasmic and Nuclear KW - 0 KW - Receptors, Glucocorticoid KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Animals KW - DNA Methylation KW - Humans KW - Receptors, Glucocorticoid -- physiology KW - Models, Biological KW - Receptors, Glucocorticoid -- genetics KW - Receptors, Cytoplasmic and Nuclear -- physiology KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Proteasome Endopeptidase Complex -- genetics KW - Epigenesis, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70222873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Intersection+of+nuclear+receptors+and+the+proteasome+on+the+epigenetic+landscape.&rft.au=Kinyamu%2C+H+Karimi%3BJefferson%2C+Wendy+N%3BArcher%2C+Trevor+K&rft.aulast=Kinyamu&rft.aufirst=H&rft.date=2008-01-01&rft.volume=49&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-28 N1 - Date created - 2008-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Biochem Sci. 2006 Feb;31(2):89-97 [16403636] BMC Genomics. 2007;8:131 [17524140] Biochem Biophys Res Commun. 2007 Aug 3;359(3):742-6 [17555712] Curr Opin Cell Biol. 2007 Jun;19(3):266-72 [17466502] Mol Cell Biol. 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reversion rate. AN - 70221384; 18202372 AB - The mouse Mitf gene encodes a transcription factor that is regulated by serine phosphorylation and is critical for the development of melanin-containing pigment cells. To test the role of phosphorylation at a particular serine, S73 in exon 2 of Mitf, we used a standard targeting strategy in mouse embryonic stem cells to change the corresponding codon into one encoding an alanine. By chance, we generated an allele in which 85,222 bp of wild-type Mitf sequence are duplicated and inserted into an otherwise correctly targeted Mitf gene. Depending on the presence or absence of a neomycin resistance cassette, this genomic rearrangement leads to animals with a white coat with or without pigmented spots or a gray coat with obligatory white and black spots. Several independent, genetically stable germline revertants that lacked the duplicated wild-type sequence but retained the targeted codon were then derived. These animals were normally pigmented, indicating that the serine-to-alanine mutation is not deleterious to melanocyte development. The fact that mosaic coat reversions occur in all mice lacking the neo-cassette and that approximately 1% of these transmit a reverted allele to their offspring places this mutation among those with the highest spontaneous reversion rates in mammals. JF - Genetics AU - Bismuth, Keren AU - Skuntz, Susan AU - Hallsson, Jón H AU - Pak, Evgenia AU - Dutra, Amalia S AU - Steingrímsson, Eiríkur AU - Arnheiter, Heinz AD - Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3706, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 259 EP - 272 VL - 178 IS - 1 SN - 0016-6731, 0016-6731 KW - Microphthalmia-Associated Transcription Factor KW - 0 KW - RNA, Messenger KW - Neomycin KW - 1404-04-2 KW - Serine KW - 452VLY9402 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Pigmentation -- drug effects KW - Animals KW - Homozygote KW - Drug Resistance -- drug effects KW - In Situ Hybridization, Fluorescence KW - Mice KW - Sequence Analysis, DNA KW - RNA, Messenger -- genetics KW - Neomycin -- pharmacology KW - Mutagenesis, Insertional -- drug effects KW - Introns -- genetics KW - Serine -- genetics KW - Phenotype KW - RNA, Messenger -- metabolism KW - Amino Acid Substitution -- drug effects KW - Alanine -- genetics KW - Gene Expression Regulation -- drug effects KW - Gene Targeting KW - Fluorescent Antibody Technique KW - Female KW - Male KW - Alleles KW - Microphthalmia-Associated Transcription Factor -- genetics KW - Germ-Line Mutation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70221384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=An+unstable+targeted+allele+of+the+mouse+Mitf+gene+with+a+high+somatic+and+germline+reversion+rate.&rft.au=Bismuth%2C+Keren%3BSkuntz%2C+Susan%3BHallsson%2C+J%C3%B3n+H%3BPak%2C+Evgenia%3BDutra%2C+Amalia+S%3BSteingr%C3%ADmsson%2C+Eir%C3%ADkur%3BArnheiter%2C+Heinz&rft.aulast=Bismuth&rft.aufirst=Keren&rft.date=2008-01-01&rft.volume=178&rft.issue=1&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/10.1534%2Fgenetics.107.081893 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2000 Feb 1;14(3):301-12 [10673502] Annu Rev Genomics Hum Genet. 2007;8:17-35 [17386002] Genetics. 2000 May;155(1):291-300 [10790403] Science. 2000 Nov 10;290(5494):1151-5 [11073452] Genetics. 2003 Jan;163(1):267-76 [12586714] J Struct Funct Genomics. 2003;3(1-4):35-44 [12836683] Pigment Cell Res. 2003 Aug;16(4):333-44 [12859616] Proc Natl Acad Sci U S A. 1988 Jan;85(1):189-92 [3422417] Science. 1991 Apr 26;252(5005):566-9 [1673574] Cell. 1991 Jun 28;65(7):1153-63 [2065352] Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):297-301 [8419934] Cell. 1993 Jul 30;74(2):395-404 [8343963] J Biol Chem. 1993 Oct 5;268(28):20687-90 [8407885] Hum Mol Genet. 1994 Apr;3(4):553-7 [8069297] Genes Dev. 1994 Nov 15;8(22):2770-80 [7958932] Mol Cell Biol. 1995 Nov;15(11):5898-905 [7565742] Cytogenet Cell Genet. 1996;74(1-2):113-7 [8893815] Development. 1997 Jun;124(12):2377-86 [9199364] Mech Dev. 1998 Jan;70(1-2):155-66 [9510032] Hum Mol Genet. 1999 Aug;8(8):1431-41 [10400990] Annu Rev Genet. 2004;38:365-411 [15568981] Annu Rev Genet. 2004;38:615-43 [15568988] Gene. 2005 Feb 28;347(1):73-82 [15715979] Nature. 2005 Jul 7;436(7047):117-22 [16001072] Pigment Cell Res. 2006 Oct;19(5):380-94 [16965267] PLoS One. 2006;1:e85 [17183716] Genesis. 2000 Feb;26(2):113-5 [10686601] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1534/genetics.107.081893 ER - TY - JOUR T1 - Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. AN - 70220815; 17970581 AB - Chronic exposure to nickel(II), chromium(VI), or inorganic arsenic (iAs) has long been known to increase cancer incidence among affected individuals. Recent epidemiological studies have found that carcinogenic risks associated with chromate and iAs exposures were substantially higher than previously thought, which led to major revisions of the federal standards regulating ambient and drinking water levels. Genotoxic effects of Cr(VI) and iAs are strongly influenced by their intracellular metabolism, which creates several reactive intermediates and byproducts. Toxic metals are capable of potent and surprisingly selective activation of stress-signaling pathways, which are known to contribute to the development of human cancers. Depending on the metal, ascorbate (vitamin C) has been found to act either as a strong enhancer or suppressor of toxic responses in human cells. In addition to genetic damage via both oxidative and nonoxidative (DNA adducts) mechanisms, metals can also cause significant changes in DNA methylation and histone modifications, leading to epigenetic silencing or reactivation of gene expression. In vitro genotoxicity experiments and recent animal carcinogenicity studies provided strong support for the idea that metals can act as cocarcinogens in combination with nonmetal carcinogens. Cocarcinogenic and comutagenic effects of metals are likely to stem from their ability to interfere with DNA repair processes. Overall, metal carcinogenesis appears to require the formation of specific metal complexes, chromosomal damage, and activation of signal transduction pathways promoting survival and expansion of genetically/epigenetically altered cells. JF - Chemical research in toxicology AU - Salnikow, Konstantin AU - Zhitkovich, Anatoly AD - National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 28 EP - 44 VL - 21 IS - 1 SN - 0893-228X, 0893-228X KW - Carcinogens KW - 0 KW - Metals KW - Chromium KW - 0R0008Q3JB KW - Nickel KW - 7OV03QG267 KW - DNA KW - 9007-49-2 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Animals KW - Humans KW - DNA -- genetics KW - Cocarcinogenesis KW - Arsenic -- toxicity KW - Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Nickel -- toxicity KW - Chromium -- toxicity KW - Neoplasms -- genetics KW - Metals -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70220815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Genetic+and+epigenetic+mechanisms+in+metal+carcinogenesis+and+cocarcinogenesis%3A+nickel%2C+arsenic%2C+and+chromium.&rft.au=Salnikow%2C+Konstantin%3BZhitkovich%2C+Anatoly&rft.aulast=Salnikow&rft.aufirst=Konstantin&rft.date=2008-01-01&rft.volume=21&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2008-01-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2006 Jun 8;25(24):3424-35 [16449970] Oncogene. 2006 Jun 22;25(26):3680-8 [16682958] Mol Carcinog. 2006 Jul;45(7):479-89 [16649251] Carcinogenesis. 2006 Jul;27(7):1481-8 [16522665] Int J Cancer. 2006 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Res. 1989 Jul-Sep;21:359-65 [2484614] Biol Trace Elem Res. 1989 Jul-Sep;21:373-81 [2484616] Biol Trace Elem Res. 1989 Jul-Sep;21:421-9 [2484623] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis. AN - 70218276; 18202368 AB - Chromosomal genes modulate Ty retrotransposon movement in the genome of Saccharomyces cerevisiae. We have screened a collection of 4739 deletion mutants to identify those that increase Ty1 mobility (Ty1 restriction genes). Among the 91 identified mutants, 80% encode products involved in nuclear processes such as chromatin structure and function, DNA repair and recombination, and transcription. However, bioinformatic analyses encompassing additional Ty1 and Ty3 screens indicate that 264 unique genes involved in a variety of biological processes affect Ty mobility in yeast. Further characterization of 33 of the mutants identified here show that Ty1 RNA levels increase in 5 mutants and the rest affect mobility post-transcriptionally. RNA and cDNA levels remain unchanged in mutants defective in transcription elongation, including ckb2Delta and elf1Delta, suggesting that Ty1 integration may be more efficient in these strains. Insertion-site preference at the CAN1 locus requires Ty1 restriction genes involved in histone H2B ubiquitination by Paf complex subunit genes, as well as BRE1 and RAD6, histone H3 acetylation by RTT109 and ASF1, and transcription elongation by SPT5. Our results indicate that multiple pathways restrict Ty1 mobility and histone modifications may protect coding regions from insertional mutagenesis. JF - Genetics AU - Nyswaner, Katherine M AU - Checkley, Mary Ann AU - Yi, Ming AU - Stephens, Robert M AU - Garfinkel, David J AD - Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland 21702-1201, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 197 EP - 214 VL - 178 IS - 1 SN - 0016-6731, 0016-6731 KW - Chromatin KW - 0 KW - DNA, Complementary KW - Retroelements KW - Saccharomyces cerevisiae Proteins KW - Index Medicus KW - Saccharomyces cerevisiae Proteins -- metabolism KW - DNA, Complementary -- genetics KW - Saccharomyces cerevisiae Proteins -- genetics KW - Models, Genetic KW - Ubiquitination KW - Transcription, Genetic KW - Computational Biology KW - Gene Deletion KW - Saccharomyces cerevisiae -- genetics KW - Retroelements -- genetics KW - Genes, Fungal KW - Mutagenesis, Insertional -- genetics KW - Chromatin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70218276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Chromatin-associated+genes+protect+the+yeast+genome+from+Ty1+insertional+mutagenesis.&rft.au=Nyswaner%2C+Katherine+M%3BCheckley%2C+Mary+Ann%3BYi%2C+Ming%3BStephens%2C+Robert+M%3BGarfinkel%2C+David+J&rft.aulast=Nyswaner&rft.aufirst=Katherine&rft.date=2008-01-01&rft.volume=178&rft.issue=1&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/10.1534%2Fgenetics.107.082602 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2001 Oct;21(19):6606-14 [11533248] Genetics. 1990 Dec;126(4):837-50 [1963869] Genetics. 1992 Feb;130(2):285-94 [1311695] Mol Cell Biol. 1992 Jun;12(6):2813-25 [1317008] Genetics. 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1;88(3):936-40 [1846969] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1534/genetics.107.082602 ER - TY - JOUR T1 - Conflicting views on chemical carcinogenesis arising from the design and evaluation of rodent carcinogenicity studies. AN - 70211274; 18197312 AB - Conflicting views have been expressed frequently on assessments of human cancer risk of environmental agents based on animal carcinogenicity data; this is primarily because of uncertainties associated with extrapolations of toxicologic findings from studies in experimental animals to human circumstances. Underlying these uncertainties are issues related to how experiments are designed, how rigorously hypotheses are tested, and to what extent assertions extend beyond actual findings. National and international health agencies regard carcinogenicity findings in well-conducted experimental animal studies as evidence of potential carcinogenic risk to humans. Controversies arise when both positive and negative carcinogenicity data exist for a specific agent or when incomplete mechanistic data suggest a possible species difference in response. Issues of experimental design and evaluation that might contribute to disparate results are addressed in this article. To serve as reliable sources of data for the evaluation of the carcinogenic potential of environmental agents, experimental studies must include a) animal models that are sensitive to the end points under investigation; b) detailed characterization of the agent and the administered doses; c) challenging doses and durations of exposure (at least 2 years for rats and mice); d) sufficient numbers of animals per dose group to be capable of detecting a true effect; e) multiple dose groups to allow characterization of dose-response relationships, f) complete and peer-reviewed histopathologic evaluations; and g) pairwise comparisons and analyses of trends based on survival-adjusted tumor incidence. Pharmacokinetic models and mechanistic hypotheses may provide insights into the biological behavior of the agent; however, they must be adequately tested before being used to evaluate human cancer risk. JF - Environmental health perspectives AU - Melnick, Ronald L AU - Thayer, Kristina A AU - Bucher, John R AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. melnickr@niehs.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 130 EP - 135 VL - 116 IS - 1 SN - 0091-6765, 0091-6765 KW - Carcinogens KW - 0 KW - Index Medicus KW - tumor pathology KW - maximally tolerated dose KW - statistical power KW - mode of action KW - rodent cancer bioassay KW - dose selection KW - Rats KW - Animals KW - Public Health KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests -- methods KW - Mice KW - Research Design KW - Risk Assessment KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70211274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Conflicting+views+on+chemical+carcinogenesis+arising+from+the+design+and+evaluation+of+rodent+carcinogenicity+studies.&rft.au=Melnick%2C+Ronald+L%3BThayer%2C+Kristina+A%3BBucher%2C+John+R&rft.aulast=Melnick&rft.aufirst=Ronald&rft.date=2008-01-01&rft.volume=116&rft.issue=1&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9989 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Natl Toxicol Program Tech Rep Ser. 2006 Feb;(533):1-264 [16741556] J Cancer Res Clin Oncol. 1999;125(3-4):219-25 [10235477] Carcinogenesis. 2000 Apr;21(4):823-6 [10753222] J Cancer Res Clin Oncol. 2000 Apr;126(4):246 [10782899] IARC Monogr Eval Carcinog Risks Hum. 1999;73:339-83 [10804962] Environ Health Perspect. 2000 May;108 Suppl 2:265-73 [10807557] Environ Health Perspect. 2000 May;108 Suppl 2:283-305 [10807559] Toxicol Sci. 2000 Jun;55(2):433-43 [10828276] IARC Monogr Eval Carcinog Risks Hum. 2000;77:41-148 [11100399] FASEB J. 2001 Jan;15(1):195-203 [11149907] Food Chem Toxicol. 2001 Jul;39(7):739-44 [11397520] Environ Health Perspect. 2001 May;109(5):437-42 [11401753] Toxicol Pathol. 1984;12(2):126-35 [11478313] Int J Occup Environ Health. 2002 Apr-Jun;8(2):144-52 [12019681] Br J Cancer. 2003 Jan 13;88(1):84-9 [12556964] Ann N Y Acad Sci. 2002 Dec;982:177-89 [12562636] Toxicol Sci. 2003 Sep;75(1):7-15 [12805639] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Environ Health Perspect. 2004 Sep;112(13):1269-74 [15345338] Arch Toxicol. 1977 Jul 19;37(3):233-6 [332116] Natl Cancer Inst Monogr. 1979 May;(51):25-35 [481577] Food Chem Toxicol. 1983 Dec;21(6):825-32 [6363233] Arch Toxicol. 1984 Oct;55(4):213-8 [6517696] Environ Health Perspect. 1984 Dec;58:385-92 [6525993] Toxicol Pathol. 1983;11(1):77-82 [6681400] J Natl Cancer Inst. 1986 Feb;76(2):283-9 [3456066] Am Ind Hyg Assoc J. 1987 May;48(5):407-13 [3591659] Fundam Appl Toxicol. 1988 Apr;10(3):385-94 [3286346] Cancer Res. 1988 Dec 1;48(23):6739-44 [3180084] Environ Health Perspect. 1989 Jul;82:109-24 [2792037] Environ Health Perspect. 1989 Jul;82:125-63 [2676495] IARC Sci Publ. 1989;(96):17-34 [2553598] Occup Environ Med. 1999 Mar;56(3):181-90 [10448327] IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 1:109-225 [10476446] N Engl J Med. 2005 Jul 14;353(2):116-8 [16014880] Natl Toxicol Program Tech Rep Ser. 2005 Sep;(494):1-358 [16362060] Natl Toxicol Program Tech Rep Ser. 2005 Dec;(517):1-255 [16362061] Cancer Res. 1990 Oct 15;50(20):6592-9 [2208121] Rev Environ Contam Toxicol. 1992;124:111-44 [1732994] Chem Res Toxicol. 1991 Mar-Apr;4(2):168-79 [1664256] Biochemistry. 1993 Jun 1;32(21):5598-604 [7684926] IARC Monogr Eval Carcinog Risks Hum. 1994;60:73-159 [7869582] Toxicol Pathol. 1994 Sep-Oct;22(5):457-72 [7899775] Fundam Appl Toxicol. 1995 Aug;27(1):95-105 [7589934] Toxicol Lett. 1995 Sep;79(1-3):107-14 [7570646] Biochim Biophys Acta. 1996 Jul 26;1302(2):93-109 [8695669] Fundam Appl Toxicol. 1996 May;31(1):1-8 [8998945] Ann N Y Acad Sci. 1996 Dec 27;804:252-65 [8993548] J Appl Toxicol. 1997 May;17 Suppl 1:S45-55 [9179727] IARC Monogr Eval Carcinog Risks Hum. 1997;69:33-343 [9336729] Med Hypotheses. 1998 Jun;50(6):525-9 [9710329] J Occup Health. 2007 May;49(3):172-82 [17575397] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.9989 ER - TY - JOUR T1 - Radiation event medical management (REMM): website guidance for health care providers. AN - 70202253; 18189170 AB - Planning for and exercising the medical response to potential chemical, biological, radiological, nuclear, and explosive (CBRNE) terrorist events are new responsibilities for most health care providers. Among potential CBRNE events, radiological and/or nuclear (rad/nuc) events are thought to have received the least attention from health care providers and planners. To assist clinicians, the U.S. Department of Health and Human Services (HHS) has created a new, innovative tool kit, the Radiation Event Medical Management (REMM) web portal (http://remm.nlm.gov). Goals of REMM include providing (1) algorithm-style, evidence-based, guidance about clinical diagnosis and treatment during mass casualty rad/nuc events; (2) just-in-time, peer-reviewed, usable information supported by sufficient background material and context to make complex diagnosis and management issues understandable to those without formal radiation medicine expertise; (3) a zip-file of complete web portal files downloadable in advance so the site would be available offline without an Internet connection; (4) a concise collection of the printable, key documents that can be taken into the field during an event; (5) a framework for medical teams and individuals to initiate rad/nuc planning and training; and (6) an extensive bibliography of key, peer-reviewed, and official guidance documents relevant to rad/nuc responses. Since its launch, REMM has been well received by individual responders and teams across the country and internationally. It has been accessed extensively, particularly during training exercises. Regular content updates and addition of new features are ongoing. The article reviews the development of REMM and some of its key content areas, features, and plans for future development. JF - Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors AU - Bader, Judith L AU - Nemhauser, Jeffrey AU - Chang, Florence AU - Mashayekhi, Bijan AU - Sczcur, Marti AU - Knebel, Ann AU - Hrdina, Chad AU - Coleman, Norman AD - National Cancer Institute, National Institutes of Health, USA. jbader@mail.nih.gov PY - 2008 SP - 1 EP - 11 VL - 12 IS - 1 KW - Index Medicus KW - United States KW - Humans KW - Algorithms KW - United States Dept. of Health and Human Services KW - Time Factors KW - Emergency Medical Technicians -- education KW - Disaster Planning -- organization & administration KW - Radioactive Hazard Release KW - Emergency Medical Technicians -- organization & administration KW - Radiation Injuries -- therapy KW - Radiation Injuries -- diagnosis KW - Internet KW - Radiation Injuries -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70202253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prehospital+emergency+care+%3A+official+journal+of+the+National+Association+of+EMS+Physicians+and+the+National+Association+of+State+EMS+Directors&rft.atitle=Radiation+event+medical+management+%28REMM%29%3A+website+guidance+for+health+care+providers.&rft.au=Bader%2C+Judith+L%3BNemhauser%2C+Jeffrey%3BChang%2C+Florence%3BMashayekhi%2C+Bijan%3BSczcur%2C+Marti%3BKnebel%2C+Ann%3BHrdina%2C+Chad%3BColeman%2C+Norman&rft.aulast=Bader&rft.aufirst=Judith&rft.date=2008-01-01&rft.volume=12&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Prehospital+emergency+care+%3A+official+journal+of+the+National+Association+of+EMS+Physicians+and+the+National+Association+of+State+EMS+Directors&rft.issn=1545-0066&rft_id=info:doi/10.1080%2F10903120701710595 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-09 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10903120701710595 ER - TY - JOUR T1 - Occupation and chronic bronchitis among Chinese women. AN - 70197182; 18188083 AB - To examine the association between occupation and chronic bronchitis among a cross section of Chinese women who participated in the Shanghai Women's Health Study. Cases were 4873 women who self-reported a physician-diagnosed bronchitis during adulthood. Controls were 9746 women randomly selected from Shanghai Women's Health Study participants and matched with the cases by year of birth and age at diagnosis. Lifetime occupational histories were obtained. Logistic regressions were used to evaluate the association between chronic bronchitis and occupation, adjusting for smoking, education, family income, and concurrent asthma. We observed excess prevalence of bronchitis for textile occupation (odds ratio, OR = 1.09; 95% CI = 1.00-1.18) and industry (OR = 1.11; 95% CI = 1.03-1.19), welders (OR = 1.40; 95% CI = 1.01-1.92), packing and baling workers (OR = 1.39; 95% CI = 1.15-1.68), and warehousing industry (OR = 1.58; 95% CI = 1.08-2.30) We also identified several new associations that may warrant further exploration and confirmation, including employment in some metal fabrication industries, postal and telecommunication industry, and a few white-collar occupations and industries. Our study indicates that the risk of chronic bronchitis among women may be increased in some occupations and industries. JF - Journal of occupational and environmental medicine AU - Krstev, Srmena AU - Ji, Bu-Tian AU - Shu, Xiao-Ou AU - Gao, Yu-Tang AU - Blair, Aaron AU - Lubin, Jay AU - Vermeulen, Roel AU - Dosemeci, Mustafa AU - Zheng, Wei AU - Rothman, Nathaniel AU - Chow, Wong-Ho AD - Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health/DHHS, 6120 Executive Boulevard, Bethesda, MD 20892, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 64 EP - 71 VL - 50 IS - 1 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Socioeconomic Factors KW - Logistic Models KW - Risk Factors KW - Humans KW - China -- epidemiology KW - Adult KW - Case-Control Studies KW - Occupational Exposure -- adverse effects KW - Aged KW - Middle Aged KW - Adolescent KW - Female KW - Bronchitis, Chronic -- epidemiology KW - Occupational Diseases -- epidemiology KW - Occupations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70197182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Occupation+and+chronic+bronchitis+among+Chinese+women.&rft.au=Krstev%2C+Srmena%3BJi%2C+Bu-Tian%3BShu%2C+Xiao-Ou%3BGao%2C+Yu-Tang%3BBlair%2C+Aaron%3BLubin%2C+Jay%3BVermeulen%2C+Roel%3BDosemeci%2C+Mustafa%3BZheng%2C+Wei%3BRothman%2C+Nathaniel%3BChow%2C+Wong-Ho&rft.aulast=Krstev&rft.aufirst=Srmena&rft.date=2008-01-01&rft.volume=50&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31815c6cdf LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-12 N1 - Date created - 2008-01-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 1998 Feb;157(2):512-7 [9476866] Am J Respir Crit Care Med. 1997 Nov;156(5):1440-6 [9372658] Occup Environ Med. 1999 May;56(5):328-33 [10472307] Occup Environ Med. 2005 Apr;62(4):212-4 [15778251] J Occup Health. 2005 Jul;47(4):286-92 [16096352] Am J Epidemiol. 2005 Dec 1;162(11):1123-31 [16236996] Toxicology. 2006 Jan 20;218(1):13-21 [16202497] Environ Health. 2006;5:2 [16476167] Am J Epidemiol. 2006 Jun 15;163(12):1118-28 [16707657] Toxicol Sci. 2006 Sep;93(1):96-104 [16740616] Respiration. 2001;68(1):4-19 [11223724] Am J Respir Crit Care Med. 2001 Mar;163(4):847-53 [11282755] Am J Respir Crit Care Med. 2001 Jun;163(7):1572-7 [11401876] Curr Opin Allergy Clin Immunol. 2002 Apr;2(2):115-21 [11964759] Am J Epidemiol. 2002 May 15;155(10):965-71 [11994237] J Gen Intern Med. 2002 Sep;17(9):684-8 [12220364] Am J Epidemiol. 2002 Oct 15;156(8):738-46 [12370162] Chest. 2002 Oct;122(4):1234-9 [12377847] Am J Respir Crit Care Med. 2003 Mar 1;167(5):787-97 [12598220] Respirology. 2003 Jun;8(2):192-8 [12753535] Eur Respir J. 2003 Sep;22(3):462-9 [14516136] Occup Environ Med. 2003 Dec;60(12):935-41 [14634185] Respir Care. 2003 Dec;48(12):1185-91; discussion 1191-3 [14651759] Scand J Work Environ Health. 1986 Feb;12(1):40-5 [3961440] Am Rev Respir Dis. 1987 Jan;135(1):194-200 [3800146] Int J Epidemiol. 1990 Dec;19(4):945-52 [2084026] Thorax. 1991 Dec;46(12):863-70 [1792631] Occup Environ Med. 1994 Jan;51(1):14-8 [8124456] Am J Respir Crit Care Med. 1994 Aug;150(2):441-7 [8049827] Occup Environ Med. 1995 Dec;52(12):800-3 [8563842] Occup Environ Med. 1996 Jan;53(1):46-50 [8563857] Med Clin North Am. 1996 Jul;80(4):851-78 [8676617] Science. 1996 Nov 1;274(5288):740-3 [8966556] Thorax. 1996 Sep;51(9):947-55 [8984710] Thorax. 1997 Jan;52(1):22-7 [9039235] Am J Ind Med. 1997 Sep;32(3):275-82 [9219658] J Occup Environ Med. 1998 Mar;40(3):223-9 [9531093] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/JOM.0b013e31815c6cdf ER - TY - JOUR T1 - Hormesis defined. AN - 70194334; 18162444 AB - Hormesis is a term used by toxicologists to refer to a biphasic dose-response to an environmental agent characterized by a low dose stimulation or beneficial effect and a high dose inhibitory or toxic effect. In the fields of biology and medicine hormesis is defined as an adaptive response of cells and organisms to a moderate (usually intermittent) stress. Examples include ischemic preconditioning, exercise, dietary energy restriction and exposures to low doses of certain phytochemicals. Recent findings have elucidated the cellular signaling pathways and molecular mechanisms that mediate hormetic responses which typically involve enzymes such as kinases and deacetylases, and transcription factors such as Nrf-2 and NF-kappaB. As a result, cells increase their production of cytoprotective and restorative proteins including growth factors, phase 2 and antioxidant enzymes, and protein chaperones. A better understanding of hormesis mechanisms at the cellular and molecular levels is leading to and to novel approaches for the prevention and treatment of many different diseases. JF - Ageing research reviews AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. mattsonm@grc.nia.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 1 EP - 7 VL - 7 IS - 1 SN - 1568-1637, 1568-1637 KW - Index Medicus KW - Animals KW - Humans KW - Diet KW - Stress, Physiological -- physiopathology KW - Drug-Related Side Effects and Adverse Reactions -- physiopathology KW - Drug Therapy KW - Dose-Response Relationship, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70194334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ageing+research+reviews&rft.atitle=Hormesis+defined.&rft.au=Mattson%2C+Mark+P&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2008-01-01&rft.volume=7&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Ageing+research+reviews&rft.issn=15681637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2008-01-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutr Neurosci. 2002 Sep;5(4):229-39 [12168685] J Nutr Health Aging. 2002 May;6(3):209-23 [11887247] Am J Physiol Cell Physiol. 2002 Sep;283(3):C917-26 [12176748] Neurobiol Aging. 2002 Sep-Oct;23(5):695-705 [12392775] Trends Biotechnol. 2002 Dec;20(12):522-31 [12443874] Neuromolecular Med. 2003;3(2):65-94 [12728191] Pharmacol Ther. 2003 Jul;99(1):1-13 [12804695] J Clin Exp Neuropsychol. 2003 Aug;25(5):625-33 [12815500] Physiol Rev. 2003 Oct;83(4):1113-51 [14506302] Clin Gastroenterol Hepatol. 2003 Sep;1(5):345-55 [15017652] Expert Opin Ther Targets. 2004 Apr;8(2):125-39 [15102554] Proc Natl Acad Sci U S A. 2004 May 4;101(18):7094-9 [15103025] Nat Rev Mol Cell Biol. 2004 Oct;5(10):781-91 [15459659] J Neurochem. 1996 Feb;66(2):869-72 [8592164] Science. 1996 Jul 5;273(5271):59-63 [8658196] Nutr Rev. 1998 Nov;56(11):317-33 [9838798] Toxicol Pathol. 1999 Mar-Apr;27(2):195-216 [10207984] Ageing Res Rev. 2004 Nov;3(4):431-43 [15541710] Ageing Res Rev. 2004 Nov;3(4):445-64 [15541711] Mol Cell Biochem. 2004 Nov;266(1-2):37-56 [15646026] Toxicol Appl Pharmacol. 2005 Feb 1;202(3):289-301 [15667834] Cell. 2005 Mar 11;120(5):701-13 [15766532] Biochem Soc Symp. 2004;(71):157-76 [15777020] J Biol Chem. 2005 May 27;280(21):20589-95 [15788402] Cancer Lett. 2005 Jun 28;224(2):171-84 [15914268] Cardiovasc Res. 2005 Aug 1;67(2):187-97 [15935334] Trends Neurosci. 2005 Aug;28(8):436-45 [15982754] Mech Ageing Dev. 2005 Sep;126(9):913-22 [15885745] Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12248-52 [16103371] J Neurochem. 2005 Sep;94(6):1676-84 [16045446] Nutr Clin Pract. 2005 Aug;20(4):451-9 [16207684] Crit Rev Toxicol. 2005 Jul;35(6):463-582 [16422392] Cell Death Differ. 2006 May;13(5):852-60 [16397579] Expert Rev Neurother. 2006 May;6(5):661-7 [16734514] Ageing Res Rev. 2006 Aug;5(3):332-53 [16899414] Biofactors. 2006;27(1-4):19-35 [17012761] Trends Neurosci. 2006 Nov;29(11):632-9 [17000014] Expert Opin Investig Drugs. 2007 Jan;16(1):25-32 [17155851] Amino Acids. 2007;32(3):299-304 [16998712] Toxicol Appl Pharmacol. 2007 Jul 1;222(1):122-8 [17459441] Vitam Horm. 2007;76:435-61 [17628185] Ageing Res Rev. 2008 Jan;7(1):49-62 [17604236] Ageing Res Rev. 2008 Jan;7(1):8-20 [17768095] Crit Rev Toxicol. 2001 Jul;31(4-5):353-424 [11504172] J Am Diet Assoc. 2002 Aug;102(8):1105-18 [12171455] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol-induced alterations on host defense after traumatic injury. AN - 70193210; 18188126 JF - The Journal of trauma AU - Greiffenstein, Patrick AU - Molina, Patricia E AD - Department of Physiology, and National Institute on Alcohol Abuse and Alcoholism, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 230 EP - 240 VL - 64 IS - 1 KW - Cytokines KW - 0 KW - Inflammation Mediators KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Alcoholism -- immunology KW - Alcoholism -- complications KW - Inflammation Mediators -- metabolism KW - Ethanol -- adverse effects KW - Cytokines -- drug effects KW - Alcoholic Intoxication -- immunology KW - Cytokines -- metabolism KW - Alcoholic Intoxication -- complications KW - Wounds and Injuries -- complications KW - Wounds and Injuries -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70193210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+trauma&rft.atitle=Alcohol-induced+alterations+on+host+defense+after+traumatic+injury.&rft.au=Greiffenstein%2C+Patrick%3BMolina%2C+Patricia+E&rft.aulast=Greiffenstein&rft.aufirst=Patrick&rft.date=2008-01-01&rft.volume=64&rft.issue=1&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+trauma&rft.issn=1529-8809&rft_id=info:doi/10.1097%2FTA.0b013e318158a4ad LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-29 N1 - Date created - 2008-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/TA.0b013e318158a4ad ER - TY - JOUR T1 - Specificity of bipolar spectrum conditions in the comorbidity of mood and substance use disorders: results from the Zurich cohort study. AN - 70190799; 18180428 AB - Although an association between mood disorders and substance use disorders has been well established, there is a lack of long-term prospective data on the order of onset and subtypes of mood disorders associated with specific substances and their progression. To estimate the respective risks posed by subtypes of mood disorders or bipolar spectrum conditions for the subsequent development of substance use disorders. Six waves of direct diagnostic interviews were administered to a sample of young adults during a 20-year period. Mood disorders and syndromes assessed at each interview were used to predict the cumulative incidences of substance use disorders at subsequent interview waves. We followed up 591 individuals (292 men and 299 women) who were selected at study enrollment from a representative sample of young adults in Zurich, Switzerland. Structured Diagnostic Interview for Psychopathologic and Somatic Syndromes, a semistructured clinical interview that collected data on the spectrum of expression of mood disorders and substance use and disorders for DSM-III-R and DSM-IV criteria. Individuals having manic symptoms were at significantly greater risk for the later onset of alcohol abuse/dependence, cannabis use and abuse/dependence, and benzodiazepine use and abuse/dependence. Bipolar II disorder predicted both alcohol abuse/dependence and benzodiazepine use and abuse/dependence. In contrast, major depression was predictive only of later benzodiazepine abuse/dependence. In comparison with major depression, bipolar II disorder was associated with the development of alcohol and benzodiazepine use and disorders. There was less specificity of manic symptoms that tended to predict all levels of the substances investigated herein. The different patterns of association between mood disorders and substance use trajectories have important implications for prevention and provide lacking information about underlying mechanisms. JF - Archives of general psychiatry AU - Merikangas, Kathleen R AU - Herrell, Richard AU - Swendsen, Joel AU - Rössler, Wulf AU - Ajdacic-Gross, Vladeta AU - Angst, Jules AD - Section on Developmental Genetic Epidemiology, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 1A201 35 Convent Dr, MSC 3720, Bethesda, MD 20892-2670, USA. kathleen.merikangas@nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 47 EP - 52 VL - 65 IS - 1 KW - Abridged Index Medicus KW - Index Medicus KW - Risk KW - Switzerland -- epidemiology KW - Humans KW - Cohort Studies KW - Adult KW - Male KW - Female KW - Comorbidity KW - Bipolar Disorder -- epidemiology KW - Mood Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70190799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Specificity+of+bipolar+spectrum+conditions+in+the+comorbidity+of+mood+and+substance+use+disorders%3A+results+from+the+Zurich+cohort+study.&rft.au=Merikangas%2C+Kathleen+R%3BHerrell%2C+Richard%3BSwendsen%2C+Joel%3BR%C3%B6ssler%2C+Wulf%3BAjdacic-Gross%2C+Vladeta%3BAngst%2C+Jules&rft.aulast=Merikangas&rft.aufirst=Kathleen&rft.date=2008-01-01&rft.volume=65&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=1538-3636&rft_id=info:doi/10.1001%2Farchgenpsychiatry.2007.18 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-14 N1 - Date created - 2008-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archgenpsychiatry.2007.18 ER - TY - JOUR T1 - A phase II clinical trial of sorafenib in androgen-independent prostate cancer. AN - 70189177; 18172272 AB - To determine if sorafenib is associated with a 4-month probability of progression-free survival, which is consistent with 50%, as determined by clinical, radiographic, and prostate-specific antigen (PSA) criteria in patients with metastatic androgen-independent prostate cancer (AIPC). Patients with progressive metastatic AIPC were enrolled in an open-label, single-arm phase II study. Sorafenib was given continuously at a dose of 400 mg orally twice daily in 28-day cycles. Clinical assessment and PSA measurement were done every cycle whereas radiographic measurements were carried out every two cycles. Twenty-two patients were enrolled in the study to date, completing a planned first stage of the trial. Baseline patient characteristics included a median age of 63.9 years (range, 50-77 years), Gleason score of 9 (range, 4-9.5), and PSA concentration of 53.3 ng/mL (range, 2-1,905 ng/mL). Fifty-nine percent of patients had received one prior chemotherapy regimen. Of the 21 patients with progressive disease, 13 progressed only by PSA criteria in the absence of evidence of clinical and radiographic progression. Two patients were found to have dramatic reduction of bone metastatic lesions as shown by bone scan, although they met PSA progression criteria at the time when scans were obtained. Toxicities likely related to treatment included one grade 3 hypertension; one grade 3 hand-foot syndrome; and grade 1/2 toxicities: fatigue, anorexia, hypertension, skin rash, nausea, and diarrhea. Results from in vitro studies suggested that PSA is not a good marker of sorafenib activity. The geometric mean exposure (AUC(0-12)) and maximum concentration (C(max)) were 9.76 h mg/L and 1.28 mg/L, respectively. The time to maximum concentration (t(max)) and accumulation ratio (after second dose) ranged from 2 to 12 h and 0.68 to 6.43, respectively. Sorafenib is relatively well tolerated in AIPC with two patients showing evidence of improved bony metastatic lesions. Interpretation of this study is complicated by discordant radiographic and PSA responses. PSA may not be an adequate biomarker for monitoring sorafenib activity. Based on these observations, further investigation using only clinical and radiographic end points as progression criteria is warranted. Accrual to the second stage of trial is ongoing. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Dahut, William L AU - Scripture, Charity AU - Posadas, Edwin AU - Jain, Lokesh AU - Gulley, James L AU - Arlen, Philip M AU - Wright, John J AU - Yu, Yunkai AU - Cao, Liang AU - Steinberg, Seth M AU - Aragon-Ching, Jeanny B AU - Venitz, Jürgen AU - Jones, Elizabeth AU - Chen, Clara C AU - Figg, William D AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 209 EP - 214 VL - 14 IS - 1 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Benzenesulfonates KW - Phenylurea Compounds KW - Pyridines KW - Niacinamide KW - 25X51I8RD4 KW - sorafenib KW - 9ZOQ3TZI87 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Disease-Free Survival KW - Humans KW - Niacinamide -- analogs & derivatives KW - Aged KW - Extracellular Signal-Regulated MAP Kinases -- drug effects KW - Prostate-Specific Antigen -- drug effects KW - Kaplan-Meier Estimate KW - Prostate-Specific Antigen -- blood KW - Treatment Outcome KW - Middle Aged KW - Male KW - Survival Analysis KW - Prostatic Neoplasms -- mortality KW - Benzenesulfonates -- therapeutic use KW - Pyridines -- pharmacokinetics KW - Benzenesulfonates -- pharmacokinetics KW - Antineoplastic Agents -- pharmacokinetics KW - Prostatic Neoplasms -- blood KW - Pyridines -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70189177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+phase+II+clinical+trial+of+sorafenib+in+androgen-independent+prostate+cancer.&rft.au=Dahut%2C+William+L%3BScripture%2C+Charity%3BPosadas%2C+Edwin%3BJain%2C+Lokesh%3BGulley%2C+James+L%3BArlen%2C+Philip+M%3BWright%2C+John+J%3BYu%2C+Yunkai%3BCao%2C+Liang%3BSteinberg%2C+Seth+M%3BAragon-Ching%2C+Jeanny+B%3BVenitz%2C+J%C3%BCrgen%3BJones%2C+Elizabeth%3BChen%2C+Clara+C%3BFigg%2C+William+D&rft.aulast=Dahut&rft.aufirst=William&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-1355 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-1355 ER - TY - JOUR T1 - XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. AN - 70186047; 18166976 AB - Single-strand breaks (SSBs) can occur in cells either directly, or indirectly following initiation of base excision repair (BER). SSBs generally have blocked termini lacking the conventional 5'-phosphate and 3'-hydroxyl groups and require further processing prior to DNA synthesis and ligation. XRCC1 is devoid of any known enzymatic activity, but it can physically interact with other proteins involved in all stages of the overlapping SSB repair and BER pathways, including those that conduct the rate-limiting end-tailoring, and in many cases can stimulate their enzymatic activities. XRCC1(-/-) mouse fibroblasts are most hypersensitive to agents that produce DNA lesions repaired by monofunctional glycosylase-initiated BER and that result in formation of indirect SSBs. A requirement for the deoxyribose phosphate lyase activity of DNA polymerase beta (pol beta) is specific to this pathway, whereas pol beta is implicated in gap-filling during repair of many types of SSBs. Elevated levels of strand breaks, and diminished repair, have been demonstrated in MMS-treated XRCC1(-/-), and to a lesser extent in pol beta(-/-) cell lines, compared with wild-type cells. Thus a strong correlation is observed between cellular sensitivity to MMS and the ability of cells to repair MMS-induced damage. Exposure of wild-type and pol beta(-/-) cells to an inhibitor of PARP activity dramatically potentiates MMS-induced cytotoxicity. XRCC1(-/-) cells are also sensitized by PARP inhibition demonstrating that PARP-mediated poly(ADP-ribosyl)ation plays a role in modulation of cytotoxicity beyond recruitment of XRCC1 to sites of DNA damage. JF - Cell research AU - Horton, Julie K AU - Watson, Mary AU - Stefanick, Donna F AU - Shaughnessy, Daniel T AU - Taylor, Jack A AU - Wilson, Samuel H AD - Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 48 EP - 63 VL - 18 IS - 1 KW - DNA-Binding Proteins KW - 0 KW - Mutagens KW - X-ray repair cross complementing protein 1 KW - metronidazole monosuccinate KW - 13182-87-1 KW - Metronidazole KW - 140QMO216E KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Index Medicus KW - Animals KW - Oxidative Stress -- physiology KW - DNA Repair-Deficiency Disorders -- genetics KW - Humans KW - Oxidative Stress -- drug effects KW - Mutagens -- toxicity KW - Metronidazole -- analogs & derivatives KW - Oxidative Stress -- genetics KW - Metronidazole -- toxicity KW - Cell Line KW - Radiation, Ionizing KW - Cell Survival KW - DNA Polymerase beta -- genetics KW - DNA Polymerase beta -- physiology KW - Cytoprotection -- radiation effects KW - DNA-Binding Proteins -- genetics KW - Cytoprotection -- genetics KW - DNA-Binding Proteins -- physiology KW - Cytoprotection -- drug effects KW - DNA Breaks, Single-Stranded UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70186047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+research&rft.atitle=XRCC1+and+DNA+polymerase+beta+in+cellular+protection+against+cytotoxic+DNA+single-strand+breaks.&rft.au=Horton%2C+Julie+K%3BWatson%2C+Mary%3BStefanick%2C+Donna+F%3BShaughnessy%2C+Daniel+T%3BTaylor%2C+Jack+A%3BWilson%2C+Samuel+H&rft.aulast=Horton&rft.aufirst=Julie&rft.date=2008-01-01&rft.volume=18&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Cell+research&rft.issn=1748-7838&rft_id=info:doi/10.1038%2Fcr.2008.7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-08 N1 - Date created - 2008-01-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2004 May 6;23(21):3872-82 [15021907] Nucleic Acids Res. 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2017-01-18 DO - http://dx.doi.org/10.1038/cr.2008.7 ER - TY - JOUR T1 - Comparison of linear array and line blot assay for detection of human papillomavirus and diagnosis of cervical precancer and cancer in the atypical squamous cell of undetermined significance and low-grade squamous intraepithelial lesion triage study. AN - 70185586; 17989194 AB - We evaluated Linear Array (LA), a newly commercialized PGMY09/11 L1 consensus primer PCR test that detects 37 human papillomavirus (HPV) genotypes by reverse line blot hybridization, for the detection of individual HPV genotypes and carcinogenic HPV and its clinical performance for detecting 2-year cumulative cervical precancer and cancer using archived specimens from the Atypical Squamous Cell of Undetermined Significance (ASCUS) and Low-Grade Squamous Intraepithelial Lesion Triage Study. LA testing was conducted on enrollment specimens from women referred because of an ASCUS Pap test. To gauge the performance of the new test, the results were compared to those of its prototype predecessor assay, Line Blot Assay (LBA), restricted to paired results (n = 3,335). LA testing was done masked to LBA results and clinical outcomes. The results of LA and LBA testing were compared for detection of carcinogenic HPV and clinical outcomes of cervical precancer and cancer. Overall, 50% and 55% of the women tested positive for carcinogenic HPV by LBA and LA, respectively (P < 0.0001). The percent agreement for carcinogenic HPV detection was 88%, percent positive agreement was 80%, and kappa was 0.76 for detection of carcinogenic HPV by the two assays. There was a significant increase in detection by LA for most of the 37 HPV genotypes targeted by both assays, including for 13 of 14 carcinogenic HPV genotypes. LA detected more multiple-genotype infections for all HPV genotypes among HPV-positive women (P < 0.0001) and for carcinogenic HPV genotypes among carcinogenic-HPV-positive women (P < 0.0001). LA was more sensitive (92.3% versus 87.1%; P = 0.003) and less specific (48.2% versus 54.0%; P < 0.0001) than LBA for 2-year cumulative cervical precancer and cancer as diagnosed by the Pathology Quality Control Group. In conclusion, we found LA to be a promising assay for the detection of HPV genotypes and carcinogenic HPV, and it may be clinically useful for the detection of cervical precancer and cancer in women with equivocal cytology. JF - Journal of clinical microbiology AU - Castle, Philip E AU - Gravitt, Patti E AU - Solomon, Diane AU - Wheeler, Cosette M AU - Schiffman, Mark AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 5004, EPS MSC 7234, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 109 EP - 117 VL - 46 IS - 1 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Uterine Neoplasms -- virology KW - DNA, Viral -- genetics KW - Female KW - Uterine Neoplasms -- pathology KW - Neoplasms, Squamous Cell -- pathology KW - Neoplasms -- virology KW - Neoplasms, Squamous Cell -- virology KW - Papillomavirus Infections -- virology KW - Uterine Cervical Dysplasia -- virology KW - Molecular Diagnostic Techniques -- methods KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- virology KW - Papillomavirus Infections -- pathology KW - Uterine Cervical Dysplasia -- pathology KW - Neoplasms -- pathology KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70185586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Comparison+of+linear+array+and+line+blot+assay+for+detection+of+human+papillomavirus+and+diagnosis+of+cervical+precancer+and+cancer+in+the+atypical+squamous+cell+of+undetermined+significance+and+low-grade+squamous+intraepithelial+lesion+triage+study.&rft.au=Castle%2C+Philip+E%3BGravitt%2C+Patti+E%3BSolomon%2C+Diane%3BWheeler%2C+Cosette+M%3BSchiffman%2C+Mark&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=1098-660X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-01-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1149-56 [15894665] JAMA. 1991 Jan 23-30;265(4):472-7 [1845912] Virology. 2005 Jun 20;337(1):76-84 [15914222] J Natl Cancer Inst. 2005 Jul 20;97(14):1066-71 [16030304] J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Am J Clin Pathol. 2005 Nov;124(5):722-32 [16203281] Br J Cancer. 2006 Jan 16;94(1):171-5 [16404371] J Clin Microbiol. 2006 Feb;44(2):571-9 [16455914] J Clin Microbiol. 2006 Jun;44(6):1998-2006 [16757590] J Natl Cancer Inst. 2006 Jun 7;98(11):765-74 [16757701] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] Lancet Oncol. 2006 Jul;7(7):547-55 [16814206] Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1268-73 [16835322] JAMA. 1994 Jun 15;271(23):1866-9 [8196145] J Natl Cancer Inst. 1995 Jun 7;87(11):796-802 [7791229] J Clin Microbiol. 1997 Mar;35(3):791-5 [9041439] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Am J Pathol. 1998 Dec;153(6):1731-9 [9846964] Lancet Oncol. 2005 Apr;6(4):204 [15830458] J Infect Dis. 2005 Jun 1;191(11):1796-807 [15871111] J Infect Dis. 2006 Nov 1;194(9):1291-9 [17041856] Cancer Res. 2006 Nov 1;66(21):10630-6 [17062559] J Clin Microbiol. 2006 Nov;44(11):3915-7 [16971652] Am J Clin Pathol. 2007 Mar;127(3):335-7 [17276947] J Clin Microbiol. 2007 May;45(5):1447-54 [17344361] J Virol Methods. 2007 Jul;143(1):45-54 [17399803] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Br J Cancer. 2007 Jul 2;97(1):129-32 [17551490] Am J Obstet Gynecol. 2007 Oct;197(4):346-55 [17904957] J Clin Microbiol. 2007 Nov;45(11):3821-3 [17898159] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] JAMA. 2000 Jan 5;283(1):87-93 [10632285] J Natl Cancer Inst. 2000 Mar 1;92(5):397-402 [10700419] Biometrics. 2000 Jun;56(2):345-51 [10877288] Acta Cytol. 2000 Sep-Oct;44(5):726-42 [11015972] J Natl Cancer Inst. 2001 Feb 21;93(4):293-9 [11181776] Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1129-36 [11700260] JAMA. 2001 Dec 26;286(24):3106-14 [11754676] JAMA. 2002 Apr 24;287(16):2114-9 [11966386] BMJ. 2002 Sep 14;325(7364):572 [12228133] JAMA. 2002 Oct 9;288(14):1749-57 [12365959] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1394-9 [12433717] J Natl Cancer Inst. 2003 Jan 1;95(1):46-52 [12509400] N Engl J Med. 2003 Feb 6;348(6):489-90 [12571255] Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):477-84 [12814990] Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):485-90 [12814991] Am J Obstet Gynecol. 2003 Jun;188(6):1383-92 [12824967] Am J Obstet Gynecol. 2003 Jun;188(6):1393-400 [12824968] Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):815-23 [14504189] Lancet. 2003 Dec 6;362(9399):1871-6 [14667741] Obstet Gynecol. 2004 Feb;103(2):304-9 [14754700] Am J Clin Pathol. 2005 Jun;123(6):896-9 [15899782] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation. AN - 70182404; 17986233 AB - A novel radioligand, 6-chloro-3-((2-(S)-azetidinyl)methoxy)-5-(2-fluoropyridin-4-yl)pyridine (NIDA522131), for imaging extrathalamic nicotinic acetylcholine receptors (nAChRs) was characterized in vitro and in vivo using positron emission tomography. The K(d) and T(1/2) of dissociation of NIDA522131 binding measured at 37 degrees C in vitro were 4.9 +/- 0.4 pmol/L and 81 +/- 5 min, respectively. The patterns of radioactivity distribution in monkey brain in vivo was similar to that of 2-[(18)F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2FA), a radioligand that has been successfully used in humans, and matched the alpha(4)beta(2)* nAChRs distribution. Comparison between [(18)F]NIDA522131 and 2FA demonstrated better in vivo binding properties of the new radioligand and substantially greater radioactivity accumulation in brain. Consistent with [(18)F]NIDA522131 elevated affinity for nAChRs and its increased lipophilicity, both, the total and non-displaceable distribution volumes were substantially higher than those of 2FA. Estimated binding potential values in different brain regions, characterizing the specificity of receptor binding, were 3-4 fold higher for [(18)F]NIDA522131 than those of 2FA. Pharmacological evaluation in mice demonstrated a toxicity that was comparable to 2FA and is in agreement with a 2300 fold higher affinity at alpha(4)beta(2)* versus alpha(3)beta(4)* nAChRs. These results suggest that [(18)F]NIDA522131 is a promising positron emission tomography radioligand for studying extrathalamic nAChR in humans. JF - Journal of neurochemistry AU - Chefer, Svetlana I AU - Pavlova, Olga A AU - Zhang, Yi AU - Vaupel, D Bruce AU - Kimes, Alane S AU - Horti, Andrew G AU - Stein, Elliot AU - Mukhin, Alexey G AD - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Department of Health and Human Services, Baltimore, Maryland, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 306 EP - 315 VL - 104 IS - 2 KW - 6-chloro-3-((2-azetidinyl)methoxy)-5-(2-fluoropyridin-5-yl)pyridine KW - 0 KW - Azetidines KW - Fluorine Radioisotopes KW - Pyridines KW - Radiopharmaceuticals KW - Receptors, Nicotinic KW - Index Medicus KW - Animals KW - Positron-Emission Tomography -- methods KW - Dose-Response Relationship, Drug KW - Binding, Competitive -- drug effects KW - Mice KW - Autoradiography KW - Rats KW - Evaluation Studies as Topic KW - Behavior, Animal -- drug effects KW - Plasma -- drug effects KW - In Vitro Techniques KW - Macaca mulatta KW - Motor Activity -- drug effects KW - Male KW - Azetidines -- chemistry KW - Thalamus -- diagnostic imaging KW - Pyridines -- chemistry KW - Fluorine Radioisotopes -- pharmacokinetics KW - Radiopharmaceuticals -- pharmacology KW - Radiopharmaceuticals -- chemical synthesis KW - Receptors, Nicotinic -- drug effects KW - Radiopharmaceuticals -- chemistry KW - Azetidines -- pharmacology KW - Pyridines -- pharmacology KW - Fluorine Radioisotopes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70182404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=NIDA522131%2C+a+new+radioligand+for+imaging+extrathalamic+nicotinic+acetylcholine+receptors%3A+in+vitro+and+in+vivo+evaluation.&rft.au=Chefer%2C+Svetlana+I%3BPavlova%2C+Olga+A%3BZhang%2C+Yi%3BVaupel%2C+D+Bruce%3BKimes%2C+Alane+S%3BHorti%2C+Andrew+G%3BStein%2C+Elliot%3BMukhin%2C+Alexey+G&rft.aulast=Chefer&rft.aufirst=Svetlana&rft.date=2008-01-01&rft.volume=104&rft.issue=2&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Validation and application of a method for the determination of buprenorphine, norbuprenorphine, and their glucuronide conjugates in human meconium. AN - 70178849; 18044957 AB - A novel liquid chromatography tandem mass spectrometry method for quantification of buprenorphine, norbuprenorphine, and glucuronidated conjugates was developed and validated. Analytes were extracted from meconium using buffer, concentrated by solid-phase extraction and quantified within 13.5 min. In order to determine free and total concentrations, specimens were analyzed with and without enzyme hydrolysis. Calibration was achieved by linear regression with a 1/x weighting factor and deuterated internal standards. All analytes were linear from 20 to 2000 ng/g with a correlation of determination of >0.98. Accuracy was >or=85.7% with intra-assay and interassay imprecisionor=85.0%. There was suppression of ionization by the polar matrix; however, this did not interfere with sensitivity or analyte quantification due to inclusion of deuterated internal standards. Analytes were stable on the autosampler, at room temperature, at 4 degrees C, and when exposed to three freeze/thaw cycles. This sensitive and specific method can be used to monitor in utero buprenorphine exposure and to evaluate correlations, if any, between buprenorphine exposure and neonatal outcomes. JF - Analytical chemistry AU - Kacinko, Sherri L AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 246 EP - 252 VL - 80 IS - 1 SN - 0003-2700, 0003-2700 KW - Glucuronides KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - norbuprenorphine KW - 7E53B4O073 KW - Index Medicus KW - Sensitivity and Specificity KW - Infant KW - Reproducibility of Results KW - Humans KW - Mothers -- psychology KW - Calibration KW - Opioid-Related Disorders -- drug therapy KW - Female KW - Pregnancy KW - Buprenorphine -- analysis KW - Meconium -- secretion KW - Chromatography, Liquid -- methods KW - Buprenorphine -- therapeutic use KW - Meconium -- chemistry KW - Tandem Mass Spectrometry -- methods KW - Glucuronides -- chemistry KW - Buprenorphine -- analogs & derivatives KW - Glucuronides -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70178849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Validation+and+application+of+a+method+for+the+determination+of+buprenorphine%2C+norbuprenorphine%2C+and+their+glucuronide+conjugates+in+human+meconium.&rft.au=Kacinko%2C+Sherri+L%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Kacinko&rft.aufirst=Sherri&rft.date=2008-01-01&rft.volume=80&rft.issue=1&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Analytical+chemistry&rft.issn=00032700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2007-12-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2005 May;33(5):689-95 [15743975] Drug Alcohol Depend. 2005 Jul;79(1):1-10 [15943939] J Mass Spectrom. 2005 Jun;40(6):739-53 [15806585] Clin Chem Lab Med. 2005;43(12):1377-9 [16309376] J Anal Toxicol. 2005 Nov-Dec;29(8):769-76 [16356333] J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 18;830(2):293-300 [16310419] Addiction. 2006 Feb;101(2):275-81 [16445556] Clin Chim Acta. 2006 Apr;366(1-2):101-11 [16413011] Drug Alcohol Depend. 2006 May 20;82(3):250-7 [16257138] Ther Drug Monit. 2006 Apr;28(2):245-51 [16628138] Acta Obstet Gynecol Scand. 2007;86(2):185-90 [17364281] J Anal Toxicol. 2007 May;31(4):214-9 [17555645] Anal Bioanal Chem. 2007 Aug;388(7):1455-65 [17370066] Addiction. 2000 Feb;95(2):239-44 [10723852] J Anal Toxicol. 2000 Oct;24(7):522-9 [11043654] Pediatrics. 2001 Feb;107(2):309-17 [11158464] J Chromatogr B Biomed Sci Appl. 2001 Apr 25;754(2):447-59 [11339288] Psychiatr Prax. 2001 Sep;28(6):267-9 [11533891] Z Geburtshilfe Neonatol. 2001 Nov-Dec;205(6):224-30 [11745008] J Pharmacol Exp Ther. 2002 Jan;300(1):26-33 [11752093] J Perinat Neonatal Nurs. 2001 Mar;14(4):61-82; quiz 105-6 [11930523] J Anal Toxicol. 2003 Mar;27(2):103-5 [12670004] Drug Alcohol Depend. 2003 May 21;70(2 Suppl):S87-101 [12738353] Forensic Sci Int. 2003 Apr 23;133(1-2):57-62 [12742690] J Anal Toxicol. 2003 Oct;27(7):464-70 [14607001] Addiction. 2003 Nov;98(11):1599-604 [14616186] Addiction. 2004 Feb;99(2):209-14 [14756713] Aust N Z J Obstet Gynaecol. 2004 Feb;44(1):80 [15089877] Forensic Sci Int. 2004 Jul 16;143(2-3):121-5 [15240031] Forensic Sci Int. 2004 Jul 16;143(2-3):153-6 [15240036] J Chromatogr. 1985 Feb 8;337(2):291-300 [3838755] J Chromatogr. 1985 Feb 27;338(1):89-98 [4019659] Naunyn Schmiedebergs Arch Pharmacol. 1988 Aug;338(2):202-6 [3141817] Pediatrics. 1988 Dec;82(6):888-95 [3186380] J Chromatogr. 1989 Feb 24;487(2):469-75 [2723013] J Anal Toxicol. 1989 Mar-Apr;13(2):100-4 [2733386] Drug Alcohol Depend. 1990 Aug;26(1):19-28 [2209411] J Forensic Sci. 1995 Mar;40(2):250-3 [7602287] J Anal Toxicol. 1996 Jul-Aug;20(4):229-35 [8835660] J Chromatogr B Biomed Sci Appl. 1997 Apr 25;692(1):67-77 [9187385] Clin Pharmacol Ther. 1997 Nov;62(5):569-71 [9390114] Clin Chem. 1997 Dec;43(12):2292-302 [9439446] Drug Metab Dispos. 1998 Aug;26(8):818-21 [9698298] Eur Addict Res. 1998;4 Suppl 1:32-6 [9767205] J Anal Toxicol. 1999 Jul-Aug;23(4):270-9 [10445490] J Mass Spectrom. 2005 Jan;40(1):70-4 [15637731] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical and molecular responses in lung cancer patients receiving Romidepsin. AN - 70175489; 18172270 AB - Our preclinical experiments indicated that Romidepsin (Depsipeptide FK228; DP) mediates growth arrest and apoptosis in cultured lung cancer cells. A phase II trial was done to examine clinical and molecular responses mediated by this histone deacetylase inhibitor in lung cancer patients. Nineteen patients with neoplasms refractory to standard therapy received 4-h DP infusions (17.8 mg/m(2)) on days 1 and 7 of a 21-day cycle. Each full course of therapy consisted of two identical 21-day cycles. Plasma DP levels were evaluated by liquid chromatography-mass spectrometry techniques. A variety of molecular end points were assessed in tumor biopsies via immunohistochemistry techniques. Long oligo arrays were used to examine gene expression profiles in laser-captured tumor cells before and after DP exposure, relative to lung cancer cells and adjacent normal bronchial epithelia from patients undergoing pulmonary resections. Nineteen patients were evaluable for toxicity assessment; 18 were evaluable for treatment response. Myelosuppression was dose limiting in one individual. No significant cardiac toxicities were observed. Maximum steady-state plasma DP concentrations ranged from 384 to 1,114 ng/mL. No objective responses were observed. Transient stabilization of disease was noted in nine patients. DP enhanced acetylation of histone H4, increased p21 expression in lung cancer cells, and seemed to shift global gene expression profiles in these cells toward those detected in normal bronchial epithelia. Although exhibiting minimal clinical efficacy at this dose and schedule, DP mediates biological effects that may warrant further evaluation of this histone deacetylase inhibitor in combination with novel-targeted agents in lung cancer patients. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Schrump, David S AU - Fischette, Maria R AU - Nguyen, Dao M AU - Zhao, Ming AU - Li, Xinmin AU - Kunst, Tricia F AU - Hancox, Ana AU - Hong, Julie A AU - Chen, G Aaron AU - Kruchin, Evgeny AU - Wright, John J AU - Rosing, Douglas R AU - Sparreboom, Alex AU - Figg, William D AU - Steinberg, Seth M AD - Thoracic Oncology Section Surgery Branch, Center for Cancer Research and Cancer Therapy Evaluation Program, National Cancer Institute, NIH, Bethesda, MD 20892, USA. david.schrump@nih.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 188 EP - 198 VL - 14 IS - 1 SN - 1078-0432, 1078-0432 KW - Antibiotics, Antineoplastic KW - 0 KW - Depsipeptides KW - Histones KW - romidepsin KW - CX3T89XQBK KW - Index Medicus KW - Gene Expression -- drug effects KW - Acetylation -- drug effects KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Aged KW - Histones -- drug effects KW - Reverse Transcriptase Polymerase Chain Reaction KW - Microdissection KW - Gene Expression Profiling KW - Adult KW - Middle Aged KW - Lasers KW - Immunohistochemistry KW - Female KW - Male KW - Lung Neoplasms -- drug therapy KW - Depsipeptides -- pharmacokinetics KW - Depsipeptides -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Antibiotics, Antineoplastic -- pharmacokinetics KW - Antibiotics, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70175489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Clinical+and+molecular+responses+in+lung+cancer+patients+receiving+Romidepsin.&rft.au=Schrump%2C+David+S%3BFischette%2C+Maria+R%3BNguyen%2C+Dao+M%3BZhao%2C+Ming%3BLi%2C+Xinmin%3BKunst%2C+Tricia+F%3BHancox%2C+Ana%3BHong%2C+Julie+A%3BChen%2C+G+Aaron%3BKruchin%2C+Evgeny%3BWright%2C+John+J%3BRosing%2C+Douglas+R%3BSparreboom%2C+Alex%3BFigg%2C+William+D%3BSteinberg%2C+Seth+M&rft.aulast=Schrump&rft.aufirst=David&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-0135 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-0135 ER - TY - JOUR T1 - Combining agents that target the tumor microenvironment improves the efficacy of anticancer therapy. AN - 70174289; 18172279 AB - Over the past 60 years, cytotoxic chemotherapy has targeted the cancer cell. Despite this, there have been few cancer cures. A new approach to cancer therapy is to target the multicellular biological entity of the tumor microenvironment. Lenalidomide, an immunomodulatory drug, sunitinib, a tyrosine kinase inhibitor, and low-dose metronomic cyclophosphamide, were tested alone and in combination for their abilities to inhibit endothelial cell tube formation, rat aortic ring outgrowth, tumor growth, and metastatic development in mice. In addition, ectopic tumor lysates were evaluated for the presence of proangiogenic proteins. The three agents alone were shown to significantly inhibit endothelial cells' ability to form tubes and significantly inhibit the multicellular microenvironment in the rat aortic ring assay (P < 0.01 and P < 0.001). This effect was also significantly augmented when the agents were combined. Furthermore, the three-drug combination was able halt the progression of tumor growth almost completely in xenograft models of ocular melanoma, colon cancer, pancreatic cancer, and cutaneous melanoma. These agents significantly decrease the number of proliferating cells in tumors, significantly increase the number of cells undergoing active cell death in tumors, and significantly decrease the number of blood vessels in treated tumors (P < 0.05). Combination therapy shows a decrease in the compensatory up-regulation of proangiogenic proteins after treatment when compared with single-agent therapy. This combination of agents causes an inhospitable microenvironment for tumor cells and shows great promise for use in the clinic. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Blansfield, Joseph A AU - Caragacianu, Diana AU - Alexander, H Richard AU - Tangrea, Michael A AU - Morita, Shane Y AU - Lorang, Dominique AU - Schafer, Peter AU - Muller, George AU - Stirling, David AU - Royal, Richard E AU - Libutti, Steven K AD - Tumor Angiogenesis Section, Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. jblansfield1@geisinger.edu Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 270 EP - 280 VL - 14 IS - 1 SN - 1078-0432, 1078-0432 KW - Indoles KW - 0 KW - Pyrroles KW - Thalidomide KW - 4Z8R6ORS6L KW - Cyclophosphamide KW - 8N3DW7272P KW - lenalidomide KW - F0P408N6V4 KW - sunitinib KW - V99T50803M KW - Index Medicus KW - Rats KW - Cyclophosphamide -- administration & dosage KW - Endothelial Cells -- drug effects KW - Animals KW - Pyrroles -- administration & dosage KW - Humans KW - Indoles -- administration & dosage KW - Xenograft Model Antitumor Assays KW - Thalidomide -- administration & dosage KW - Mice KW - Cell Line, Tumor KW - Fluorescent Antibody Technique KW - Female KW - Thalidomide -- analogs & derivatives KW - Cell Proliferation -- drug effects KW - Neoplasms, Experimental -- blood supply KW - Neovascularization, Pathologic -- drug therapy KW - Neoplasms, Experimental -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70174289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Combining+agents+that+target+the+tumor+microenvironment+improves+the+efficacy+of+anticancer+therapy.&rft.au=Blansfield%2C+Joseph+A%3BCaragacianu%2C+Diana%3BAlexander%2C+H+Richard%3BTangrea%2C+Michael+A%3BMorita%2C+Shane+Y%3BLorang%2C+Dominique%3BSchafer%2C+Peter%3BMuller%2C+George%3BStirling%2C+David%3BRoyal%2C+Richard+E%3BLibutti%2C+Steven+K&rft.aulast=Blansfield&rft.aufirst=Joseph&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-1562 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-1562 ER - TY - JOUR T1 - Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial. AN - 70173729; 18165396 AB - To evaluate whether 6 months of raloxifene was effective in treatment of chronic pelvic pain in women with endometriosis. Women with chronic pelvic pain and no endometriosis treatment for 6 months underwent laparoscopy for excision of all lesions. Those with biopsy-proven endometriosis were randomly allocated to raloxifene (180 mg) or placebo daily. A second laparoscopy was performed at 2 years, or earlier, if pain returned. Return of pain was defined as 2 months of pain equal to or more severe than that at study entry. Menstrual cycles and adverse events were recorded. The log rank test was used to compare the time to return of pain by drug group. Analyses were done as intent-to-treat. A total of 127 of 158 women underwent surgery. Of these, 93 had biopsy-confirmed endometriosis and were randomly assigned to study treatment. Menstrual cycle length, pelvic pain severity, quality of life, bone mineral density, and adverse events did not differ between treatment groups. The Data Safety Monitoring Committee terminated the study early when the raloxifene group experienced pain (P=.03) and had second surgery (P=.016) significantly sooner than the placebo group. Interestingly, biopsy-proven endometriosis was not associated with return of pain (P=.6). Raloxifene significantly shortened the time to return of chronic pelvic pain. Because recurrence of endometriosis lesions did not correlate with return of pain, other factors are implicated in pelvic pain. ClinicalTrials.gov, www.cliicaltrials.gov, NCT00001848 I. JF - Obstetrics and gynecology AU - Stratton, Pamela AU - Sinaii, Ninet AU - Segars, James AU - Koziol, Deloris AU - Wesley, Robert AU - Zimmer, Carolyn AU - Winkel, Craig AU - Nieman, Lynnette K AD - Reproductive Biology and Medicine Branch, National Institutes of Health, Bethesda, Maryland, USA. ps79c@nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 88 EP - 96 VL - 111 IS - 1 SN - 0029-7844, 0029-7844 KW - Selective Estrogen Receptor Modulators KW - 0 KW - Raloxifene Hydrochloride KW - 4F86W47BR6 KW - Abridged Index Medicus KW - Index Medicus KW - Laparoscopy KW - Humans KW - Adult KW - Treatment Outcome KW - Quality of Life KW - Chronic Disease KW - Recurrence KW - Female KW - Pelvic Pain -- drug therapy KW - Selective Estrogen Receptor Modulators -- adverse effects KW - Endometriosis -- surgery KW - Endometriosis -- drug therapy KW - Raloxifene Hydrochloride -- adverse effects KW - Endometriosis -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70173729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Return+of+chronic+pelvic+pain+from+endometriosis+after+raloxifene+treatment%3A+a+randomized+controlled+trial.&rft.au=Stratton%2C+Pamela%3BSinaii%2C+Ninet%3BSegars%2C+James%3BKoziol%2C+Deloris%3BWesley%2C+Robert%3BZimmer%2C+Carolyn%3BWinkel%2C+Craig%3BNieman%2C+Lynnette+K&rft.aulast=Stratton&rft.aufirst=Pamela&rft.date=2008-01-01&rft.volume=111&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/10.1097%2F01.AOG.0000297307.35024.b5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2007-12-31 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00001848; ClinicalTrials.gov N1 - SuppNotes - Cited By: Cochrane Database Syst Rev. 2000;(2):CD001019 [10796731] J Clin Endocrinol Metab. 2006 Oct;91(10):3941-6 [16868059] N Engl J Med. 2001 Jul 26;345(4):266-75 [11474666] Reprod Fertil Dev. 2001;13(4):331-6 [11800172] Climacteric. 1999 Dec;2(4):268-83 [11910661] Obstet Gynecol. 2002 May;99(5 Pt 1):709-19 [11978277] Fertil Steril. 2002 Oct;78(4):743-9 [12372450] N Engl J Med. 2003 Feb 13;348(7):618-29 [12584371] Hum Reprod. 2003 Sep;18(9):1922-7 [12923150] Cochrane Database Syst Rev. 2003;(4):CD001297 [14583930] J Pain. 2003 Sep;4(7):372-80 [14622679] Ann N Y Acad Sci. 2003 Nov;997:378-88 [14644845] Int Rev Cytol. 2003;231:91-127 [14713004] Qual Life Res. 2004 Apr;13(3):705-13 [15130032] Cochrane Database Syst Rev. 2004;(3):CD003678 [15266496] Expert Rev Anticancer Ther. 2004 Aug;4(4):523-32 [15270657] Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11094-8 [15256593] Fertil Steril. 2004 Oct;82(4):878-84 [15482763] Stat Med. 1982 Apr-Jun;1(2):121-9 [7187087] Med Care. 1990 Nov;28(11):1056-72 [2250492] Hum Reprod. 1993 Nov;8(11):1792-5 [8288740] Stat Med. 1993 Dec 15;12(23):2219-31 [8310191] Fertil Steril. 1994 Oct;62(4):696-700 [7926075] Ann N Y Acad Sci. 1995 Jun 12;761:355-60 [7625735] J Clin Oncol. 1996 Jan;14(1):78-84 [8558225] Fertil Steril. 1997 May;67(5):817-21 [9130884] J Clin Endocrinol Metab. 1998 Jan;83(1):6-13 [9435408] J Reprod Med. 1998 Mar;43(3 Suppl):287-92 [9564663] JAMA. 1998 May 13;279(18):1445-51 [9600478] Pain. 1998 Aug;77(2):151-61 [9766833] Am J Manag Care. 1999 May;5(5 Suppl):S276-90 [10537662] Lancet. 2004 Nov 13-19;364(9447):1789-99 [15541453] Science. 2005 Jun 10;308(5728):1587-9 [15947176] Neuroendocrinology. 2005;81(3):193-9 [16020928] J Endocrinol Invest. 2005;28(10 Suppl):85-9 [16550730] Pain. 2001 May;92(1-2):229-34 [11323144] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/01.AOG.0000297307.35024.b5 ER - TY - JOUR T1 - Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. AN - 70173027; 17675102 AB - Neurotensin is a peptide that has been suggested to mimic the actions of antipsychotics, but little is known about how it affects synaptic transmission in the striatum, the major input nucleus of the basal ganglia. In this study we measured the effects of neurotensin on EPSCs from medium spiny projection neurons in the sensorimotor striatum, a region implicated in habit formation and control of motor sequences. We found that bath-applied neurotensin reduced glutamate release from presynaptic terminals, and that this effect required retrograde endocannabinoid signaling, as it was prevented by the CB1 cannabinoid receptor antagonist AM251. Neurotensin-mediated inhibition of striatal EPSCs was also blocked by antagonists of D2-like dopamine receptors and group I metabotropic glutamate receptors, as well as by intracellular calcium chelation and phospholipase C inhibition. These results suggest that neurotensin can indirectly engage an endocannabinoid-mediated negative feedback signal to control glutamatergic input to the basal ganglia. JF - Neuropharmacology AU - Yin, Henry H AU - Adermark, Louise AU - Lovinger, David M AD - NIAAA/NIH, Bethesda, MD 20892, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 79 EP - 86 VL - 54 IS - 1 SN - 0028-3908, 0028-3908 KW - Cannabinoid Receptor Modulators KW - 0 KW - Endocannabinoids KW - Piperidines KW - Pyrazoles KW - Quinolines KW - SR 142948 KW - Neurotensin KW - 39379-15-2 KW - AM 251 KW - 3I4FA44MAI KW - Index Medicus KW - Rats KW - Piperidines -- pharmacology KW - Patch-Clamp Techniques -- methods KW - Pyrazoles -- pharmacology KW - Animals, Newborn KW - Animals KW - Rats, Sprague-Dawley KW - Quinolines -- pharmacology KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - In Vitro Techniques KW - Electric Stimulation KW - Corpus Striatum -- cytology KW - Neurotensin -- pharmacology KW - Excitatory Postsynaptic Potentials -- drug effects KW - Cannabinoid Receptor Modulators -- metabolism KW - Neurons -- drug effects KW - Signal Transduction -- drug effects KW - Cannabinoid Receptor Modulators -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70173027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Neurotensin+reduces+glutamatergic+transmission+in+the+dorsolateral+striatum+via+retrograde+endocannabinoid+signaling.&rft.au=Yin%2C+Henry+H%3BAdermark%2C+Louise%3BLovinger%2C+David+M&rft.aulast=Yin&rft.aufirst=Henry&rft.date=2008-01-01&rft.volume=54&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-18 N1 - Date created - 2007-12-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 1998 Sep 1;18(17):6977-89 [9712666] J Pharmacol Exp Ther. 1997 Feb;280(2):802-12 [9023294] Nat Neurosci. 1999 Apr;2(4):358-63 [10204543] Neuron. 2005 Jan 20;45(2):257-68 [15664177] J Neurosci. 2005 Jul 20;25(29):6826-35 [16033892] J Neurosci. 2005 Nov 9;25(45):10537-45 [16280591] Nat Rev Neurosci. 2006 Jun;7(6):464-76 [16715055] Proc Natl Acad Sci U S A. 2006 May 23;103(21):8251-6 [16698932] Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13345-50 [16938887] Peptides. 2006 Oct;27(10):2385-404 [16891042] J Neurosci. 2006 Nov 15;26(46):11811-20 [17108154] Neuroreport. 2002 May 7;13(6):763-6 [11997683] Neuroscience. 1999;94(3):775-83 [10579568] Science. 1999 Nov 26;286(5445):1745-9 [10576743] Neuroscience. 2000;97(2):293-302 [10799761] J Neurophysiol. 2001 Jan;85(1):468-71 [11152748] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8048-53 [11427716] Neuron. 2001 Aug 16;31(3):463-75 [11516402] Nat Neurosci. 2002 May;5(5):446-51 [11976704] J Neurochem. 2002 Apr;81(2):325-34 [12064480] Life Sci. 2003 Jun 27;73(6):801-11 [12801600] Eur J Neurosci. 2003 Sep;18(5):1247-53 [12956723] Nat Rev Neurosci. 2003 Nov;4(11):873-84 [14595399] Endocrinology. 2003 Dec;144(12):5556-67 [14500581] Eur J Neurosci. 2004 Jan;19(1):181-9 [14750976] J Neurosci. 2004 Feb 18;24(7):1673-9 [14973237] Synapse. 2004 Jun 1;52(3):176-87 [15065218] J Neurosci. 2004 Jun 30;24(26):5955-65 [15229243] Eur J Pharmacol. 1983 Sep 16;93(1-2):27-33 [6628546] Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):267-70 [3713871] J Comp Neurol. 1987 Mar 15;257(3):383-95 [2435769] J Neurochem. 1988 Apr;50(4):1026-31 [2831296] Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):13-7 [3368012] J Neurosci. 1992 Feb;12(2):652-63 [1531499] J Neurosci. 1992 Nov;12(11):4224-33 [1359031] Brain Res Mol Brain Res. 1992 Oct;15(3-4):332-8 [1331689] Neuropeptides. 1992 Jul;22(3):175-83 [1436404] Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3447-51 [8097317] Neurosci Lett. 1993 Apr 30;153(2):192-6 [7687049] J Pharmacol Exp Ther. 1994 Oct;271(1):460-71 [7965747] Synapse. 1995 Aug;20(4):362-4 [7482295] J Comp Neurol. 1996 Sep 9;373(1):76-89 [8876464] J Neurosci. 1999 Apr 1;19(7):2789-98 [10087090] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiple pathways involved in the biosynthesis of anandamide. AN - 70172980; 17631919 AB - Endocannabinoids, including anandamide (arachidonoyl ethanolamide) have been implicated in the regulation of a growing number of physiological and pathological processes. Anandamide can be generated from its membrane phospholipid precursor N-arachidonoyl phosphatidylethanolamine (NAPE) through hydrolysis by a phospholipase D (NAPE-PLD). Recent evidence indicates, however, the existence of two additional, parallel pathways. One involves the sequential deacylation of NAPE by alpha,beta-hydrolase 4 (Abhd4) and the subsequent cleavage of glycerophosphate to yield anandamide, and the other one proceeds through phospholipase C-mediated hydrolysis of NAPE to yield phosphoanandamide, which is then dephosphorylated by phosphatases, including the tyrosine phosphatase PTPN22 and the inositol 5' phosphatase SHIP1. Conversion of synthetic NAPE to AEA by brain homogenates from wild-type and NAPE-PLD(-/-) mice can proceed through both the PLC/phosphatase and Abdh4 pathways, with the former being dominant at shorter (<10 min) and the latter at longer (60 min) incubations. In macrophages, the endotoxin-induced synthesis of anandamide proceeds uniquely through the phospholipase C/phosphatase pathway. JF - Neuropharmacology AU - Liu, Jie AU - Wang, Lei AU - Harvey-White, Judith AU - Huang, Bill X AU - Kim, Hee-Yong AU - Luquet, Serge AU - Palmiter, Richard D AU - Krystal, Gerald AU - Rai, Ravi AU - Mahadevan, Anu AU - Razdan, Raj K AU - Kunos, George AD - Laboratory of Physiologic Studies, NIAAA/NIH, 5625 Fishers Lane, MS-9413, Bethesda, MD 20892-9413, USA. jiel@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 1 EP - 7 VL - 54 IS - 1 SN - 0028-3908, 0028-3908 KW - Arachidonic Acids KW - 0 KW - Endocannabinoids KW - Glycerophosphates KW - Lipopolysaccharides KW - Polyunsaturated Alkamides KW - Protein Synthesis Inhibitors KW - RNA, Small Interfering KW - Neomycin KW - 1404-04-2 KW - Hydrolases KW - EC 3.- KW - Phosphoric Monoester Hydrolases KW - EC 3.1.3.2 KW - Protein Tyrosine Phosphatase, Non-Receptor Type 22 KW - EC 3.1.3.48 KW - Ptpn22 protein, mouse KW - Inositol Polyphosphate 5-Phosphatases KW - EC 3.1.3.56 KW - Inpp5d protein, mouse KW - EC 3.1.3.86 KW - Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases KW - Type C Phospholipases KW - EC 3.1.4.- KW - N-acylphosphatidylethanolamine phospholipase D, mouse KW - EC 3.1.4.4 KW - Phospholipase D KW - anandamide KW - UR5G69TJKH KW - Index Medicus KW - Animals KW - Drug Interactions KW - Phosphoric Monoester Hydrolases -- deficiency KW - Lipopolysaccharides -- pharmacology KW - Hydrolases -- metabolism KW - Macrophages -- drug effects KW - Glycerophosphates -- metabolism KW - Neomycin -- pharmacology KW - RNA, Small Interfering -- metabolism KW - Chromatography, High Pressure Liquid KW - Type C Phospholipases -- metabolism KW - Mice, Knockout KW - Phospholipase D -- deficiency KW - Cell Line, Transformed KW - Macrophages -- metabolism KW - Mice KW - Transfection -- methods KW - Protein Synthesis Inhibitors -- pharmacology KW - Protein Tyrosine Phosphatase, Non-Receptor Type 22 -- deficiency KW - Chromatography, Thin Layer KW - Hydrolysis -- drug effects KW - Arachidonic Acids -- biosynthesis KW - Metabolic Networks and Pathways -- physiology KW - Metabolic Networks and Pathways -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70172980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Multiple+pathways+involved+in+the+biosynthesis+of+anandamide.&rft.au=Liu%2C+Jie%3BWang%2C+Lei%3BHarvey-White%2C+Judith%3BHuang%2C+Bill+X%3BKim%2C+Hee-Yong%3BLuquet%2C+Serge%3BPalmiter%2C+Richard+D%3BKrystal%2C+Gerald%3BRai%2C+Ravi%3BMahadevan%2C+Anu%3BRazdan%2C+Raj+K%3BKunos%2C+George&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2008-01-01&rft.volume=54&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-18 N1 - Date created - 2007-12-31 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Biol Chem. 1983 Aug 10;258(15):9302-6 [6308001] Biochim Biophys Acta. 1981 May 22;664(2):445-8 [7248333] Nature. 1994 Dec 15;372(6507):686-91 [7990962] Eur J Biochem. 1996 Aug 15;240(1):53-62 [8797835] Genes Dev. 1998 Jun 1;12(11):1610-20 [9620849] J Clin Invest. 2005 May;115(5):1298-305 [15864349] Blood. 2005 Jun 15;105(12):4685-92 [15701712] Biochem J. 2005 Jul 1;389(Pt 1):241-7 [15760304] Diabetes. 2005 Oct;54(10):2838-43 [16186383] Biochemistry. 2006 Apr 18;45(15):4720-6 [16605240] J Biol Chem. 2006 May 5;281(18):12325-35 [16527816] Mol Cell Biol. 2006 Aug;26(15):5888-94 [16847339] J Biol Chem. 2006 Sep 8;281(36):26465-72 [16818490] Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13345-50 [16938887] Pharmacol Rev. 2006 Sep;58(3):389-462 [16968947] Genesis. 2000 Feb;26(2):113-5 [10686601] Nat Med. 2003 Jan;9(1):76-81 [12461523] J Biol Chem. 2003 Nov 7;278(45):45034-9 [12949078] Science. 2004 Jan 30;303(5658):685-9 [14752163] J Biol Chem. 2004 Feb 13;279(7):5298-305 [14634025] Biochem J. 2004 Jun 15;380(Pt 3):749-56 [14998370] Biochem Biophys Res Commun. 1979 Sep 27;90(2):628-33 [508325] Science. 1992 Dec 18;258(5090):1946-9 [1470919] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Cardiac toxicity in breast cancer survivors: review of potential cardiac problems. AN - 70172695; 18172247 AB - As breast cancer survival is increased by the diagnosis of earlier-stage disease and treatments improve, the side effects of cancer treatments, such as cardiotoxicity, remain clinically important. Although physicians have known for 30 years that anthracyclines cause acute and chronic cardiotoxicity, the cardiotoxic effects of radiation therapy, hormonal therapy (including tamoxifen and the aromatase inhibitors), and chemotherapy with taxanes and trastuzumab treatment have emerged more recently. This review examines the cardiac toxicity of adjuvant therapy, monitoring for early changes and existing guidelines for monitoring cardiac function in patients with breast cancer. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Bird, Brian R J Healey AU - Swain, Sandra M AD - Breast Cancer Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, MD, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 14 EP - 24 VL - 14 IS - 1 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Humans KW - Heart -- radiation effects KW - Clinical Trials as Topic KW - Heart -- drug effects KW - Survivors KW - Female KW - Breast Neoplasms -- therapy KW - Heart Diseases -- physiopathology KW - Heart Diseases -- etiology KW - Radiotherapy -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70172695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Cardiac+toxicity+in+breast+cancer+survivors%3A+review+of+potential+cardiac+problems.&rft.au=Bird%2C+Brian+R+J+Healey%3BSwain%2C+Sandra+M&rft.aulast=Bird&rft.aufirst=Brian+R+J&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-1033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2008-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-1033 ER - TY - JOUR T1 - Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. AN - 70172684; 18166357 AB - Chronic alcohol drinking accelerates liver fibrosis in patients with viral hepatitis that cannot be fully explained by ethanol-enhanced liver damage. Here, we identified a novel mechanism by which alcohol accelerates liver fibrosis: inhibition of the antifibrotic effects of natural killer (NK) cells and interferon-gamma (IFN-gamma). Alcohol administration was achieved by feeding mice with a liquid diet containing 5% ethanol for 8 weeks. Liver fibrosis was induced by administration of carbon tetrachloride (CCl(4)) for 2 weeks. Hepatic stellate cells (HSCs) were also isolated and cultured for in vitro studies. CCl(4) treatment induced greater fibrosis and less apoptosis of HSCs in ethanol-fed mice compared with pair-fed mice. Polyinosinic-polycytidylic acid (Poly I:C) or IFN-gamma treatment inhibited liver fibrosis in pair-fed but not in ethanol-fed mice. Poly I:C activation of NK cell cytotoxicity against HSCs was attenuated in ethanol-fed mice compared with pair-fed mice, which was due to reduced natural killer group 2 member D (NKG2D), tumor necrosis factor-related apoptosis-inducing ligand, and IFN-gamma expression on NK cells from ethanol-fed mice. In vitro, HSCs from ethanol-fed mice were resistant to IFN-gamma-induced cell cycle arrest and apoptosis compared with pair-fed mice. Such resistance was due to diminished IFN-gamma activation of signal transducer and activator of transcription 1 (STAT1) in HSCs from ethanol-fed mice caused by the induction of suppressors of cytokine signaling proteins and the production of oxidative stress. Finally, HSCs from ethanol-fed mice were resistant to NK cell killing, which can be reversed by transforming growth factor-beta1 (TGF-beta1) neutralizing antibody. Chronic ethanol consumption attenuates the antifibrotic effects of NK/IFN-gamma/STAT1 in the liver, representing new and different therapeutic targets with which to treat alcoholic liver fibrosis. JF - Gastroenterology AU - Jeong, Won-Il AU - Park, Ogyi AU - Gao, Bin AD - Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 248 EP - 258 VL - 134 IS - 1 KW - Interferon Inducers KW - 0 KW - STAT1 Transcription Factor KW - Poly I-C KW - 24939-03-5 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Poly I-C -- therapeutic use KW - Animals KW - Interferon Inducers -- therapeutic use KW - Mice, Inbred C57BL KW - Cell Culture Techniques KW - Disease Models, Animal KW - Mice KW - STAT1 Transcription Factor -- physiology KW - Male KW - Liver Cirrhosis, Alcoholic -- etiology KW - Liver Cirrhosis, Alcoholic -- prevention & control KW - Interferon-gamma -- therapeutic use KW - Liver Cirrhosis, Alcoholic -- pathology KW - Killer Cells, Natural -- physiology KW - Hepatocytes -- physiology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70172684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Abrogation+of+the+antifibrotic+effects+of+natural+killer+cells%2Finterferon-gamma+contributes+to+alcohol+acceleration+of+liver+fibrosis.&rft.au=Jeong%2C+Won-Il%3BPark%2C+Ogyi%3BGao%2C+Bin&rft.aulast=Jeong&rft.aufirst=Won-Il&rft.date=2008-01-01&rft.volume=134&rft.issue=1&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2007.09.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Hepatology. 2002 Nov;36(5 Suppl 1):S220-5 [12407597] Shock. 2002 Jul;18(1):58-63 [12095135] J Immunol. 2004 Jul 1;173(1):42-9 [15210757] J Immunol. 2004 Aug 15;173(4):2715-24 [15294990] Semin Liver Dis. 2004 Aug;24(3):305-15 [15349807] Hepatology. 1991 May;13(5):815-9 [2029987] Adv Exp Med Biol. 1991;288:229-36 [1950734] Hepatology. 1992 Sep;16(3):776-84 [1505921] Alcohol Alcohol. 1995 Jan;30(1):55-60 [7538299] Liver. 1995 Dec;15(6):300-6 [8609809] Hepatology. 1996 May;23(5):1189-99 [8621153] Hepatology. 1997 Sep;26(3 Suppl 1):39S-42S [9305662] Alcohol Clin Exp Res. 1997 Oct;21(7):1226-31 [9347083] J Biol Chem. 1998 Dec 11;273(50):33750-8 [9837963] Alcohol Clin Exp Res. 1998 Dec;22(9):1927-42 [9884135] Alcohol Clin Exp Res. 1999 May;23(5):904-10 [10371412] Hepatology. 1999 Jul;30(1):196-202 [10385656] Alcohol Clin Exp Res. 1999 Sep;23(9):1543-51 [10512322] J Clin Invest. 2005 Feb;115(2):209-18 [15690074] J Immunol. 2005 Oct 15;175(8):5541-50 [16210663] Clin Gastroenterol Hepatol. 2005 Aug;3(8):819-28 [16234012] Hepatology. 2005 Nov;42(5):1109-17 [16250053] Hepatology. 2006 Feb;43(2 Suppl 1):S54-62 [16447271] Gastroenterology. 2006 Feb;130(2):435-52 [16472598] Dig Dis. 2005;23(3-4):264-74 [16508291] Hepatology. 2006 Apr;43(4):872-8 [16502397] J Viral Hepat. 2006 May;13(5):322-8 [16637863] J Hepatol. 2006 Jul;45(1):60-71 [16515819] Cell Mol Biol (Noisy-le-grand). 2006;52(1):77-87 [16914099] Alcohol Clin Exp Res. 2006 Sep;30(9):1615-23 [16930225] Hepatology. 2006 Sep;44(3):521-6 [16941687] Hepatology. 2006 Dec;44(6):1441-51 [17133483] J Hepatol. 2007 Feb;46(2):295-303 [17125875] Hepatology. 2007 Jan;45(1):242-9 [17187439] J Clin Invest. 2007 Mar;117(3):539-48 [17332881] Hepatology. 2007 Mar;45(3):569-78 [17326152] Hepatology. 2008 Feb;47(2):729-36 [18167066] J Clin Gastroenterol. 2003 Mar;36(3):242-52 [12590237] Alcohol Clin Exp Res. 2000 Mar;24(3):291-9 [10776665] Alcohol. 2000 May;21(1):87-95 [10946161] Biochem J. 2000 Jul 15;349(Pt 2):427-34 [10880341] Hepatology. 2002 Jan;35(1):62-73 [11786960] J Biol Chem. 2002 Mar 22;277(12):9853-64 [11782477] Comment In: Gastroenterology. 2008 Jan;134(1):351-3 [18166364] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1053/j.gastro.2007.09.034 ER - TY - JOUR T1 - A modified alkaline comet assay for measuring DNA repair capacity in human populations. AN - 70172440; 18159959 AB - Trzeciak, A. R., Barnes, J. and Evans, M. K. A Modified Alkaline Comet Assay for Measuring DNA Repair Capacity in Human Populations. Radiat. Res. 169, 110-121 (2008). Use of the alkaline comet assay to assess DNA repair capacity in human populations has been limited by several factors, including lack of methodology for use of unstimulated cryopreserved peripheral blood mononuclear cells (PBMCs), insufficient control of interexperimental variability, and limited analysis of DNA repair kinetics. We show that unstimulated cryopreserved PBMCs can be used in DNA repair studies performed using the comet assay. We have applied data standardization for the analysis of DNA repair capacity using negative and positive internal standards as controls for interexperimental variability. Our standardization procedure also uses negative controls, which provides a way to minimize the interference of interindividual variation in baseline DNA damage levels on DNA repair capacity measurements in populations. DNA repair capacity was assessed in a small human cohort using the parameters described in the literature including initial DNA damage, half-time of DNA repair, and residual DNA damage after 30 and 60 min. We have also introduced new DNA repair capacity parameter, initial rate of DNA repair. There was no difference in DNA repair capacity between fresh and cryopreserved PBMCs when measured by the Olive tail moment and tail DNA. The use of DNA repair capacity parameters in assessment of fast and slow single-strand break repair components is discussed. JF - Radiation research AU - Trzeciak, Andrzej R AU - Barnes, Janice AU - Evans, Michele K AD - Laboratory of Cellular and Molecular Biology, and National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6825, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 110 EP - 121 VL - 169 IS - 1 SN - 0033-7587, 0033-7587 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Leukocytes -- metabolism KW - Leukocytes -- radiation effects KW - Cells, Cultured KW - Kinetics KW - Humans KW - DNA Damage -- genetics KW - DNA Repair -- genetics KW - DNA -- genetics KW - DNA -- analysis KW - Comet Assay -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70172440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=A+modified+alkaline+comet+assay+for+measuring+DNA+repair+capacity+in+human+populations.&rft.au=Trzeciak%2C+Andrzej+R%3BBarnes%2C+Janice%3BEvans%2C+Michele+K&rft.aulast=Trzeciak&rft.aufirst=Andrzej&rft.date=2008-01-01&rft.volume=169&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women. AN - 70172133; 18166347 AB - Systemic inhibition of DNA methylation causes cancers in animals, in part by inducing genetic instability. Epidemiologic evidence linking low genomic methylation in systemic blood DNA to carcinogenesis is limited, however, specifically to the colorectum, in which genetic instability is a primary etiologic factor. We examined genomic methylation of leukocyte DNA in relation to colorectal adenoma (CRA) among asymptomatic women (40-79 years of age) participating in a multicenter colonoscopy screening study (CONCeRN Study, 2000-2002). Of all participants who completed self-administered risk factor and food frequency questionnaires, peripheral blood donation, and colonoscopy, 115 pairs of CRA cases and controls with matching age and month of blood draw were studied. Genomic methylation of leukocyte DNA was determined by liquid chromatography mass spectrometry. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Compared with women in the lowest tertile of genomic methylation, women in the second (OR, 0.72; 95% CI: 0.34-1.52) and third tertiles (OR, 0.17; 95% CI: 0.06-0.49) had lower risk of CRA (P trend = .002). The inverse relationship was stronger for nonadvanced than for advanced adenoma and, less notably, for proximal than for distal adenoma. The association was also moderately more protective with low rather than high total folate intake but did not differ by other nutrients involved in 1-carbon metabolism or colorectal cancer risk factors. Our findings regarding asymptomatic CRA implicate systemic genomic methylation as a potential etiologic factor for an early stage of CRA. JF - Gastroenterology AU - Lim, Unhee AU - Flood, Andrew AU - Choi, Sang-Woon AU - Albanes, Demetrius AU - Cross, Amanda J AU - Schatzkin, Arthur AU - Sinha, Rashmi AU - Katki, Hormuzd A AU - Cash, Brooks AU - Schoenfeld, Phillip AU - Stolzenberg-Solomon, Rachael AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 47 EP - 55 VL - 134 IS - 1 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Nutritional Status KW - Life Style KW - Colonoscopy KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Female KW - Adenoma -- metabolism KW - DNA Methylation KW - Colorectal Neoplasms -- pathology KW - Colorectal Neoplasms -- metabolism KW - Leukocytes -- physiology KW - Colorectal Neoplasms -- genetics KW - Adenoma -- pathology KW - Adenoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70172133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Genomic+methylation+of+leukocyte+DNA+in+relation+to+colorectal+adenoma+among+asymptomatic+women.&rft.au=Lim%2C+Unhee%3BFlood%2C+Andrew%3BChoi%2C+Sang-Woon%3BAlbanes%2C+Demetrius%3BCross%2C+Amanda+J%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi%3BKatki%2C+Hormuzd+A%3BCash%2C+Brooks%3BSchoenfeld%2C+Phillip%3BStolzenberg-Solomon%2C+Rachael&rft.aulast=Lim&rft.aufirst=Unhee&rft.date=2008-01-01&rft.volume=134&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/10.1053%2Fj.gastro.2007.10.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2008-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2002 Aug 12;21(35):5400-13 [12154403] J Nutr. 2002 Aug;132(8 Suppl):2340S-2344S [12163689] Int J Cancer. 2002 Oct 10;101(5):403-8 [12216066] Anal Chem. 2002 Sep 1;74(17):4526-31 [12236365] Science. 2003 Apr 18;300(5618):455 [12702868] Science. 2003 Apr 18;300(5618):489-92 [12702876] Gastroenterology. 2003 May;124(5):1240-8 [12730865] J Nutr. 2003 Nov;133(11 Suppl 1):3731S-3739S [14608107] Int J Colorectal Dis. 2004 Mar;19(2):95-101 [14534800] Cancer Res. 1988 Mar 1;48(5):1159-61 [3342396] Carcinogenesis. 1992 Jun;13(6):1039-42 [1376218] J Natl Cancer Inst. 1993 Jun 2;85(11):875-84 [8492316] Drug Metab Rev. 1994;26(1-2):185-99 [8082564] J Natl Cancer Inst. 1998 Jan 7;90(1):57-62 [9428784] Int J Epidemiol. 1998 Jun;27(3):382-7 [9698124] Nat Genet. 1999 Feb;21(2):163-7 [9988266] Exp Biol Med (Maywood). 2004 Nov;229(10):988-95 [15522834] Oncogene. 2004 Nov 18;23(54):8841-6 [15480421] Int J Cancer. 2005 Feb 20;113(5):825-8 [15499620] N Engl J Med. 2005 May 19;352(20):2061-8 [15901859] Nutr Rev. 2005 Jun;63(6 Pt 1):183-95 [16028562] J Natl Cancer Inst. 2005 Sep 21;97(18):1317-9 [16174847] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] Semin Oncol. 2005 Oct;32(5):521-30 [16210093] J Nutr. 2005 Nov;135(11):2703-9 [16251634] J Nutr. 2005 Dec;135(12 Suppl):2967S-2971S [16317156] Curr Opin Gastroenterol. 2006 Jul;22(4):382-90 [16760754] Curr Top Microbiol Immunol. 2006;310:251-74 [16909914] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):108-14 [17220338] JAMA. 2007 Jun 6;297(21):2351-9 [17551129] JAMA. 2007 Jun 6;297(21):2408-9 [17551134] Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1325-9 [17626997] J Nutr. 2007 Sep;137(9):2114-20 [17709451] J Nutr. 2000 Feb;130(2):129-32 [10720158] Semin Thromb Hemost. 2000;26(3):227-32 [11011840] Cancer Epidemiol Biomarkers Prev. 2001 Jan;10(1):69-74 [11205492] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62 [11352869] J Med Genet. 2001 May;38(5):285-303 [11333864] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5606-11 [11929966] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1053/j.gastro.2007.10.013 ER - TY - JOUR T1 - GTP-independent rapid and slow endocytosis at a central synapse. AN - 70171739; 18066059 AB - Vesicle endocytosis is essential for maintaining synaptic transmission. Its key step, membrane scission, is thought to be mediated by the GTPase dynamin in all forms of endocytosis at synapses. Our findings indicate that GTP-independent and probably dynamin-independent endocytosis co-exist with GTP- and dynamin-dependent endocytosis at the same synaptic nerve terminal, the calyx of Held, in rats. This previously undescribed form of endocytosis could be slow (tens of seconds) and/or rapid (a few seconds), similar to GTP- and dynamin-dependent endocytosis. It was activated during intense stimulation, whereas GTP- and dynamin-dependent endocytosis dominated during mild stimulation. These results establish a new model, in which vesicles are divided into two pools depending on their requirement for GTP and dynamin for retrieval. The GTP- and dynamin-dependent pool has higher priority for release and retrieval, but limited capacity, saturation of which leads to release and thus retrieval of GTP- and dynamin-independent vesicles. JF - Nature neuroscience AU - Xu, Jianhua AU - McNeil, Benjamin AU - Wu, Wei AU - Nees, David AU - Bai, Li AU - Wu, Ling-Gang AD - National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 45 EP - 53 VL - 11 IS - 1 SN - 1097-6256, 1097-6256 KW - FM1 43 KW - 0 KW - Pyridinium Compounds KW - Quaternary Ammonium Compounds KW - Synaptotagmin II KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - Guanosine Triphosphate KW - 86-01-1 KW - Dynamins KW - EC 3.6.5.5 KW - Index Medicus KW - Quaternary Ammonium Compounds -- metabolism KW - Patch-Clamp Techniques -- methods KW - Animals KW - Electric Stimulation -- methods KW - Dose-Response Relationship, Drug KW - Dose-Response Relationship, Radiation KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Rats KW - Animals, Newborn KW - Excitatory Postsynaptic Potentials -- drug effects KW - Pyridinium Compounds -- metabolism KW - Excitatory Postsynaptic Potentials -- radiation effects KW - In Vitro Techniques KW - Rats, Wistar KW - Brain Stem -- cytology KW - Time Factors KW - Excitatory Postsynaptic Potentials -- physiology KW - Synapses -- physiology KW - Dynamins -- metabolism KW - Neurons -- drug effects KW - Neurons -- cytology KW - Endocytosis -- physiology KW - Guanosine Triphosphate -- pharmacology KW - Guanosine Triphosphate -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70171739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+neuroscience&rft.atitle=GTP-independent+rapid+and+slow+endocytosis+at+a+central+synapse.&rft.au=Xu%2C+Jianhua%3BMcNeil%2C+Benjamin%3BWu%2C+Wei%3BNees%2C+David%3BBai%2C+Li%3BWu%2C+Ling-Gang&rft.aulast=Xu&rft.aufirst=Jianhua&rft.date=2008-01-01&rft.volume=11&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Nature+neuroscience&rft.issn=10976256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2007-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. AN - 70166527; 17855015 AB - To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score. Patients with localized prostate cancer received amifostine as a rectal suspension 30-45 minutes before daily three-dimensional conformal radiation therapy. The first 18 patients received 1 g of amifostine, and the next 12 patients received 2 g. Toxicity was assessed at baseline, during treatment, and at follow-up visits by using RTOG grading and the EPIC Quality of Life (QoL) 50-item questionnaire. The Bowel Function subset of the bowel domain (EPIC-BF), which targets symptom severity, and the Bowel Bother subset of the bowel domain (EPIC-BB), which assesses QoL, were evaluated and compared with the RTOG GI toxicity score. Median follow-up was 30 months (range, 18-36 months). Overall, EPIC-BF and EPIC-BB scores both tracked closely with the RTOG GI toxicity score. Seven weeks after the start of radiation therapy, the incidence of RTOG Grade 2 toxicity was 33% in the 1-g group (6/18 patients) compared with 0% (0/12 patients) in the 2-g group and tended toward statistical significance (p = 0.06). A significant difference between amifostine groups was observed using the EPIC-BF score at 7 weeks (p = 0.04). A difference in EPIC-BB scores between dose groups was evident at 7 weeks (p = 0.07) and was significant at 12 months (p = 0.04). Higher doses of amifostine produced significant improvements in acute and late bowel QoL (up to 1 year after therapy), measured using the EPIC score. JF - International journal of radiation oncology, biology, physics AU - Simone, Nicole L AU - Ménard, Cynthia AU - Soule, Benjamin P AU - Albert, Paul S AU - Guion, Peter AU - Smith, Sharon AU - Godette, Denise AU - Crouse, Nancy S AU - Sciuto, Linda C AU - Cooley-Zgela, Theresa AU - Camphausen, Kevin AU - Coleman, C Norman AU - Singh, Anurag K AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 90 EP - 95 VL - 70 IS - 1 SN - 0360-3016, 0360-3016 KW - Radiation-Protective Agents KW - 0 KW - Amifostine KW - M487QF2F4V KW - Index Medicus KW - Severity of Illness Index KW - Dose-Response Relationship, Drug KW - Radiation Injuries -- prevention & control KW - Humans KW - Rectum -- radiation effects KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Administration, Rectal KW - Male KW - Adenocarcinoma -- radiotherapy KW - Radiation-Protective Agents -- administration & dosage KW - Quality of Life KW - Proctitis -- prevention & control KW - Amifostine -- administration & dosage KW - Prostatic Neoplasms -- radiotherapy KW - Radiotherapy, Conformal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70166527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Intrarectal+amifostine+during+external+beam+radiation+therapy+for+prostate+cancer+produces+significant+improvements+in+Quality+of+Life+measured+by+EPIC+score.&rft.au=Simone%2C+Nicole+L%3BM%C3%A9nard%2C+Cynthia%3BSoule%2C+Benjamin+P%3BAlbert%2C+Paul+S%3BGuion%2C+Peter%3BSmith%2C+Sharon%3BGodette%2C+Denise%3BCrouse%2C+Nancy+S%3BSciuto%2C+Linda+C%3BCooley-Zgela%2C+Theresa%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman%3BSingh%2C+Anurag+K&rft.aulast=Simone&rft.aufirst=Nicole&rft.date=2008-01-01&rft.volume=70&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-07 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Oncol Biol Phys. 2005 Jun 1;62(2):486-93 [15890591] Radiat Res. 1995 Jul;143(1):107-10 [7597137] JAMA. 2005 Sep 14;294(10):1233-9 [16160131] Int J Impot Res. 2006 Jan-Feb;18(1):69-76 [16094413] Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1008-13 [16730138] Strahlenther Onkol. 1999 Nov;175 Suppl 4:27-9 [10584137] Radiother Oncol. 2000 Jan;54(1):11-9 [10719695] J Clin Oncol. 2000 Jun;18(11):2226-33 [10829042] Int J Radiat Oncol Biol Phys. 1978 Jul-Aug;4(7-8):643-7 [213406] Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):735-42 [14967428] Urology. 2000 Dec 20;56(6):899-905 [11113727] Radiat Res. 1978 Oct;76(1):172-9 [216048] Int J Radiat Oncol Biol Phys. 1983 Apr;9(4):507-13 [6303992] Radiobiol Radiother (Berl). 1983;24(3):357-64 [6314424] Int J Radiat Oncol Biol Phys. 2003 Jun 1;56(2):454-61 [12738320] Int J Radiat Oncol Biol Phys. 2003 Jul 15;56(4):1154-60 [12829154] CA Cancer J Clin. 2001 Jan-Feb;51(1):15-36 [11577478] Int J Radiat Oncol Biol Phys. 2001 Nov 15;51(4):988-93 [11704322] Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1097-105 [12128107] Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1160-4 [12128116] Semin Oncol. 2002 Dec;29(6 Suppl 19):57-60 [12577246] Gastroenterology. 1986 Sep;91(3):644-50 [3015711] Int J Radiat Oncol Biol Phys. 1991 Oct;21(5):1241-6 [1657841] Int J Radiat Oncol Biol Phys. 1992;22(4):799-802 [1312078] Cancer. 1992 Jun 1;69(11):2820-5 [1315211] Cancer. 1994 Oct 15;74(8):2379-84 [7922989] Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1316-21 [16029787] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk assessment to guide the prevention of cervical cancer. AN - 70164734; 18162804 AB - Advances in screening and diagnosis make it increasingly possible to prevent cervical cancer. However, if misused or poorly understood, these new tools will only increase costs and potentially harm patients without benefit. As a framework for standardized care that maximizes patient safety and well-being, we propose that a risk model be adopted to guide clinical management now and in the future. The model would use thresholds of increasing risk for cervical precancer and treatable cancer to guide clinical decision making for screening intensity, diagnostic evaluation, or treatment. Experts would decide on these risk thresholds and stratum based on the patient risk to benefit, independent of current (e.g., cytology, carcinogenic human papillomavirus testing, and colposcopy) and future methods of measuring risk. A risk management model for cervical cancer prevention, based on appropriate clinical actions that correspond to risk stratum, can result in better allocation of resources to and increased safety for women at the greatest risk and increased well-being for women at the lowest risk. JF - Journal of lower genital tract disease AU - Castle, Philip E AU - Sideri, Mario AU - Jeronimo, Jose AU - Solomon, Diane AU - Schiffman, Mark AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 1 EP - 7 VL - 12 IS - 1 SN - 1089-2591, 1089-2591 KW - Index Medicus KW - Risk Factors KW - Papillomaviridae -- isolation & purification KW - Humans KW - Vaginal Smears KW - Female KW - Colposcopy KW - Risk Assessment KW - Neoplasms, Squamous Cell -- prevention & control KW - Uterine Cervical Neoplasms -- prevention & control KW - Papillomavirus Infections -- diagnosis KW - Cervical Intraepithelial Neoplasia -- surgery KW - Uterine Cervical Neoplasms -- diagnosis KW - Algorithms KW - Neoplasms, Squamous Cell -- diagnosis KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Dysplasia -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70164734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lower+genital+tract+disease&rft.atitle=Risk+assessment+to+guide+the+prevention+of+cervical+cancer.&rft.au=Castle%2C+Philip+E%3BSideri%2C+Mario%3BJeronimo%2C+Jose%3BSolomon%2C+Diane%3BSchiffman%2C+Mark&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2008-01-01&rft.volume=12&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+lower+genital+tract+disease&rft.issn=10892591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-27 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pesticides and atopic and nonatopic asthma among farm women in the Agricultural Health Study. AN - 70163303; 17932376 AB - Risk factors for asthma among farm women are understudied. We evaluated pesticide and other occupational exposures as risk factors for adult-onset asthma. Studying 25,814 farm women in the Agricultural Health Study, we used self-reported history of doctor-diagnosed asthma with or without eczema and/or hay fever to create two case groups: patients with atopic asthma and those with nonatopic asthma. We assessed disease-exposure associations with polytomous logistic regression. At enrollment (1993-1997), 702 women (2.7%) reported a doctor's diagnosis of asthma after age 19 years (282 atopic, 420 nonatopic). Growing up on a farm (61% of all farm women) was protective for atopic asthma (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.43-0.70) and, to a lesser extent, for nonatopic asthma (OR, 0.83; 95%CI, 0.68-1.02; P value for difference = 0.008). Pesticide use was almost exclusively associated with atopic asthma. Any use of pesticides on the farm was associated only with atopic asthma (OR, 1.46; 95% CI, 1.14-1.87). This association with pesticides was strongest among women who had grown up on a farm. Women who grew up on farms and did not apply pesticides had the lowest overall risk of atopic asthma (OR, 0.41; 95% CI, 0.27-0.62) compared with women who neither grew up on farms nor applied pesticides. A total of 7 of 16 insecticides, 2 of 11 herbicides, and 1 of 4 fungicides were significantly associated with atopic asthma; only permethrin use on crops was associated with nonatopic asthma. These findings suggest that pesticides may contribute to atopic asthma, but not nonatopic asthma, among farm women. JF - American journal of respiratory and critical care medicine AU - Hoppin, Jane A AU - Umbach, David M AU - London, Stephanie J AU - Henneberger, Paul K AU - Kullman, Greg J AU - Alavanja, Michael C R AU - Sandler, Dale P AD - NIEHS Epidemiology Branch, MD A3-05, P.O. Box 12233, Research Triangle Park, NC 27709-2233, USA. hoppin1@niehs.nih.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 11 EP - 18 VL - 177 IS - 1 KW - Pesticides KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Causality KW - Regression Analysis KW - Dermatitis, Atopic -- epidemiology KW - Humans KW - Dermatitis, Atopic -- prevention & control KW - Iowa KW - Cross-Sectional Studies KW - Risk Factors KW - Adult KW - Cohort Studies KW - North Carolina KW - Middle Aged KW - Rhinitis, Allergic, Seasonal -- prevention & control KW - Female KW - Rhinitis, Allergic, Seasonal -- epidemiology KW - Asthma -- epidemiology KW - Agricultural Workers' Diseases -- prevention & control KW - Agricultural Workers' Diseases -- epidemiology KW - Respiratory Hypersensitivity -- epidemiology KW - Asthma -- prevention & control KW - Respiratory Hypersensitivity -- prevention & control KW - Occupational Exposure -- adverse effects KW - Pesticides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70163303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Pesticides+and+atopic+and+nonatopic+asthma+among+farm+women+in+the+Agricultural+Health+Study.&rft.au=Hoppin%2C+Jane+A%3BUmbach%2C+David+M%3BLondon%2C+Stephanie+J%3BHenneberger%2C+Paul+K%3BKullman%2C+Greg+J%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2008-01-01&rft.volume=177&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1535-4970&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 1993 Jan;4(1):55-62 [8420582] Toxicol Sci. 1998 Jul;44(1):63-9 [9720142] Toxicol Sci. 2005 Jan;83(1):166-76 [15470232] Toxicol Ind Health. 2003 Jul;19(2-6):93-108 [15697179] Biochem Biophys Res Commun. 2005 Jul 8;332(3):793-9 [15907790] Clin Exp Allergy. 2005 Jul;35(7):835-7 [16008664] Rev Saude Publica. 2005 Dec;39(6):973-81 [16341409] Am J Epidemiol. 2006 Jun 15;163(12):1129-37 [16611668] J Appl Toxicol. 2006 Sep-Oct;26(5):458-65 [16871525] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Ann Allergy. 1961 Apr;19:397-401 [13783892] Naunyn Schmiedebergs Arch Pharmacol. 1999 Dec;360(6):699-710 [10619188] Am J Ind Med. 2000 May;37(5):451-8 [10723039] BMJ. 2000 Jul 8;321(7253):88-92 [10884260] Am J Respir Crit Care Med. 2002 Mar 1;165(5):683-9 [11874814] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Eur Respir J. 2003 Feb;21(2):323-31 [12608449] Environ Health Perspect. 2003 May;111(5):724-30 [12727601] Histochem Cell Biol. 2003 Jul;120(1):33-9 [12838427] Occup Environ Med. 2003 Aug;60(8):e3 [12883030] Curr Opin Pulm Med. 2004 Jan;10(1):44-50 [14749605] Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L963-9 [14704222] Thorax. 2004 May;59(5):381-6 [15115863] Am J Respir Crit Care Med. 2004 Jun 15;169(12):1308-13 [15070818] Biol Pharm Bull. 2004 Jul;27(7):1136-9 [15256756] J Occup Environ Med. 2004 Aug;46(8):856-65 [15300138] Am J Ind Med. 2004 Oct;46(4):396-9 [15376208] Aust N Z J Med. 1985 Feb;15(1):66-8 [3859269] Eur Respir J. 1989 Nov;2(10):940-5 [2606194] Am Rev Respir Dis. 1992 Oct;146(4):884-7 [1416414] J Occup Med. 1994 Nov;36(11):1240-6 [7861269] Lancet. 2006 Aug 26;368(9537):804-13 [16935691] Int J Epidemiol. 1996 Jun;25(3):609-16 [8671563] Eur Respir J. 1996 Jul;9(7):1407-13 [8836651] Int J Immunopharmacol. 1997 Mar;19(3):149-56 [9306154] Occup Environ Med. 1998 Jan;55(1):65-70 [9536166] Occup Med. 1993 Oct-Dec;8(4):869-82 [8303498] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypoxia alters progression of the erythroid program. AN - 70162509; 17936496 AB - Hypoxia can induce erythropoiesis through regulated increase of erythropoietin (Epo) production. We investigated the direct influence of oxygen tension (pO(2)) in the physiologic range (2-8%) on erythroid progenitor cell differentiation using cultures of adult human hematopoietic progenitor cells exposed to decreasing (20% to 2%) pO(2) and independent of variation in Epo levels. Decreases in hemoglobin (Hb)-containing cells were observed at the end of the culture period with decreasing pO(2). This is due, in part, to a reduction in cell growth and, at 2% O(2), a marked increase in cell toxicity. Analysis of the kinetics of cell differentiation showed an increase in the proportion of cells with glycophorin-A expression and Hb accumulation at physiologic pO(2). Cells were characterized by an early induction of gamma-globin expression and a delay and reduction in peak levels of beta-globin expression. Overall, fetal Hb and gamma-globin expression were increased at physiologic pO(2), but these increases were reduced at 2% O(2) as cultures become cytotoxic. At reduced pO(2), induction of Epo-receptor (Epo-R) by Epo was decreased and delayed, analogous to the delay in beta-globin induction. The oxygen-dependent reduction of Epo-R can account for the associated cytotoxicity at 2% O(2). Epo induction of erythroid transcription factors, EKLF, GATA-1, and SCL/Tal-1, was also delayed and decreased at reduced pO(2), consistent with lower levels of Epo-R and resultant Epo signaling. These changes in Epo-R and globin gene expression raise the possibility that the early increase of gamma-globin is a consequence of reduced Epo signaling and a delay in induction of erythroid transcription factors. JF - Experimental hematology AU - Rogers, Heather M AU - Yu, Xiaobing AU - Wen, Jie AU - Smith, Reginald AU - Fibach, Eitan AU - Noguchi, Constance Tom AD - Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1822, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 17 EP - 27 VL - 36 IS - 1 SN - 0301-472X, 0301-472X KW - Antigens, CD36 KW - 0 KW - Blood Proteins KW - Glycophorin KW - Hemoglobins KW - RNA, Messenger KW - Receptors, Erythropoietin KW - Recombinant Proteins KW - Transcription Factors KW - Erythropoietin KW - 11096-26-7 KW - Globins KW - 9004-22-2 KW - Fetal Hemoglobin KW - 9034-63-3 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Receptors, Erythropoietin -- biosynthesis KW - Humans KW - Glycophorin -- biosynthesis KW - Antigens, CD36 -- genetics KW - Globins -- genetics KW - Cells, Cultured -- cytology KW - Cells, Cultured -- drug effects KW - Transcription Factors -- genetics KW - Transcription Factors -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Blood Proteins -- genetics KW - Globins -- biosynthesis KW - Gene Expression Profiling KW - Hemoglobins -- biosynthesis KW - Fetal Hemoglobin -- genetics KW - Antigens, CD36 -- biosynthesis KW - Erythropoietin -- pharmacology KW - Receptors, Erythropoietin -- genetics KW - Adult KW - Blood Proteins -- biosynthesis KW - Fetal Hemoglobin -- biosynthesis KW - Signal Transduction KW - Partial Pressure KW - Erythroid Precursor Cells -- drug effects KW - Erythropoiesis -- physiology KW - Oxygen -- pharmacology KW - Cell Hypoxia -- physiology KW - Erythroid Precursor Cells -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70162509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=Hypoxia+alters+progression+of+the+erythroid+program.&rft.au=Rogers%2C+Heather+M%3BYu%2C+Xiaobing%3BWen%2C+Jie%3BSmith%2C+Reginald%3BFibach%2C+Eitan%3BNoguchi%2C+Constance+Tom&rft.aulast=Rogers&rft.aufirst=Heather&rft.date=2008-01-01&rft.volume=36&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1960 Feb 6;185:396-7 [13837955] J Clin Invest. 1960 Jul;39:1107-13 [13792722] Br J Haematol. 2005 Feb;128(4):562-70 [15686468] Mol Cell. 2005 Feb 4;17(3):453-62 [15694345] Exp Hematol. 2005 Mar;33(3):259-71 [15730849] Mol Cell Biol. 2005 Jun;25(12):4853-62 [15923604] Cells Tissues Organs. 2005;180(3):151-8 [16260861] Exp Physiol. 2005 Nov;90(6):791-7 [16157658] Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17065-70 [16286657] Mol Cell. 2006 Feb 17;21(4):521-31 [16483933] Nat Med. 2006 Jul;12(7):793-800 [16799557] Blood. 2007 Feb 1;109(3):868-73 [17032916] Blood. 2004 May 1;103(9):3326-35 [14715640] Nat Med. 2004 Aug;10(8):858-64 [15235597] FASEB J. 2004 Sep;18(12):1462-4 [15240563] Blood. 2004 Oct 1;104(7):2073-80 [15205261] Intern Med. 2004 Aug;43(8):649-59 [15468961] Ann Hematol. 2004 Nov;83(11):673-86 [15322761] Br J Haematol. 1980 Apr;44(4):535-46 [6155136] Exp Hematol. 1979;7 Suppl 5:200-9 [95616] Exp Hematol. 1985 Nov;13(10):989-93 [4054250] Blood. 1986 Jan;67(1):99-104 [2416368] Eur J Haematol. 1988 Feb;40(2):126-9 [3278928] Blood. 2000 Feb 1;95(3):863-9 [10648397] Gene. 2000 Dec 31;261(2):277-87 [11167015] Mol Cell Biol. 2001 Apr;21(7):2413-22 [11259590] Development. 2002 Jan;129(2):505-16 [11807041] Nat Genet. 2003 Oct;35(2):190-4 [14517543] Exp Hematol. 2003 Nov;31(11):1089-96 [14585374] Blood. 2004 Mar 1;103(5):1929-33 [14592835] Blood. 1993 Dec 1;82(11):3229-40 [8241495] Br J Haematol. 1994 Sep;88(1):39-45 [7528530] Cell. 1995 Oct 6;83(1):59-67 [7553874] Hemoglobin. 1995 Sep;19(5):263-75 [8537230] Exp Hematol. 1997 Oct;25(11):1187-94 [9328456] Nature. 1998 Oct 1;395(6701):511-6 [9774108] Br J Haematol. 1998 Nov;103(2):317-25 [9827900] Hemoglobin. 1998 Sep-Nov;22(5-6):445-58 [9859928] Science. 1999 Feb 12;283(5404):987-90 [9974392] Science. 1999 Feb 12;283(5404):990-3 [9974393] J Biol Chem. 2005 Jan 21;280(3):1724-32 [15494394] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. AN - 70160778; 17875804 AB - We describe the safety and immunogenicity of a combined vaccine of 2 leukemia-associated antigenic peptides, PR1 and WT1. Eight patients with myeloid malignancies received one subcutaneous dose each of PR1 and WT1 vaccines in Montanide adjuvant, with granulocyte-macrophage colony-stimulating factor. Patients were reviewed weekly for 4 weeks to monitor toxicity and immunologic responses. Toxicity was limited to grades 1 to 2. Using peptide/HLA-A 0201 tetramers and intracellular interferon-gamma staining, CD8(+) T cells against PR1 or WT1 were detected in 8 of 8 patients after a single vaccination. To monitor the kinetics of vaccine-induced CD8(+) T-cell responses and disease regression after vaccination, absolute PR1 and WT1(+)CD8(+) T-cell numbers and WT1 expression were studied weekly after vaccination. Responses occurred as early as 1 week after vaccination. After vaccination, the emergence of PR1 or WT1(+)CD8(+) T cells was associated with a decrease in WT1 mRNA expression as a marker of minimal residual disease, suggesting a vaccine-driven antileukemia effect. Conversely, loss of response was associated with reappearance of WT1 transcripts (P < .01). This is the first demonstration that a combined PR1 and WT1 vaccine is immunogenic. These results support further studies of combination immunization strategies in leukemia patients. JF - Blood AU - Rezvani, Katayoun AU - Yong, Agnes S M AU - Mielke, Stephan AU - Savani, Bipin N AU - Musse, Laura AU - Superata, Jeanine AU - Jafarpour, Behnam AU - Boss, Carol AU - Barrett, A John AD - Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1201, USA. rezvanik@nhlbi.nih.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 236 EP - 242 VL - 111 IS - 1 SN - 0006-4971, 0006-4971 KW - Cancer Vaccines KW - 0 KW - HLA-A Antigens KW - HLA-A*02:01 antigen KW - HLA-A2 Antigen KW - Oligopeptides KW - RMFPNAPYL KW - RNA, Messenger KW - WT1 Proteins KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Oligopeptides -- administration & dosage KW - Oligopeptides -- immunology KW - Neoplasm, Residual -- therapy KW - Aged KW - Immunotherapy -- methods KW - RNA, Messenger -- metabolism KW - CD8-Positive T-Lymphocytes -- immunology KW - Kinetics KW - Neoplasm, Residual -- immunology KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Cancer Vaccines -- administration & dosage KW - Leukemia, Myeloid, Acute -- therapy KW - WT1 Proteins -- immunology KW - WT1 Proteins -- genetics KW - Leukemia, Myeloid, Acute -- immunology KW - HLA-A Antigens -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70160778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Leukemia-associated+antigen-specific+T-cell+responses+following+combined+PR1+and+WT1+peptide+vaccination+in+patients+with+myeloid+malignancies.&rft.au=Rezvani%2C+Katayoun%3BYong%2C+Agnes+S+M%3BMielke%2C+Stephan%3BSavani%2C+Bipin+N%3BMusse%2C+Laura%3BSuperata%2C+Jeanine%3BJafarpour%2C+Behnam%3BBoss%2C+Carol%3BBarrett%2C+A+John&rft.aulast=Rezvani&rft.aufirst=Katayoun&rft.date=2008-01-01&rft.volume=111&rft.issue=1&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-24 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00313638; ClinicalTrials.gov N1 - SuppNotes - Cited By: Acta Haematol. 1999;102(2):72-6 [10529509] Blood. 2007 Sep 15;110(6):1924-32 [17505014] Immunogenetics. 2000 Feb;51(2):99-107 [10663572] Blood. 2000 Apr 1;95(7):2198-203 [10733485] Nat Med. 2000 Sep;6(9):1018-23 [10973322] Nat Immunol. 2000 Nov;1(5):433-40 [11062504] Methods Mol Med. 2002;68:223-37 [11901505] Blood. 2002 Sep 15;100(6):2132-7 [12200377] Blood. 2003 Mar 1;101(5):1698-704 [12406915] J Clin Oncol. 2003 May 15;21(10):1988-95 [12743153] Int J Hematol. 2003 Jul;78(1):56-61 [12894852] Blood. 2003 Oct 15;102(8):2892-900 [12829610] Leukemia. 2003 Dec;17(12):2474-86 [14562124] Leukemia. 2003 Dec;17(12):2318-57 [14562125] Leukemia. 2004 Jan;18(1):165-6 [14603333] Br J Haematol. 2004 Jun;125(5):590-600 [15147374] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13885-90 [15365188] Blood. 1994 Nov 1;84(9):3071-9 [7949179] Leukemia. 1995 Jun;9(6):1060-7 [7596170] Blood. 1996 Oct 1;88(7):2450-7 [8839835] Blood. 1997 Feb 15;89(4):1405-12 [9028964] Blood. 1997 Aug 1;90(3):1217-25 [9242555] Blood. 1997 Oct 1;90(7):2529-34 [9326217] J Exp Med. 1997 Nov 3;186(9):1407-18 [9348298] J Immunol. 2005 Jun 15;174(12):8210-8 [15944330] Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8799-807 [16361568] Blood. 2006 Jan 1;107(1):205-12 [16144796] Clin Cancer Res. 2006 Jan 1;12(1):34-42 [16397021] Cytotherapy. 2007;9(3):245-51 [17464756] Blood. 2000 Jan 1;95(1):286-93 [10607714] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation. AN - 70159190; 17925481 AB - Although primarily required for the growth, differentiation, and survival of mast cells, Kit ligand (stem cell factor) is also required for optimal antigen-mediated mast cell activation. Therefore, concurrent inhibition of Kit- and FcepsilonRI-mediated signaling would be an attractive approach for targeting mast cell-driven allergic reactions. To explore this concept, we examined the effects of hypothemycin, a molecule that we identified as having such properties, in human and mouse mast cells. Hypothemycin blocked Kit activation and Kit-mediated mast cell adhesion in a similar manner to the well characterized Kit inhibitor imatinib mesylate (imatinib). In contrast to imatinib, however, hypothemycin also effectively inhibited FcepsilonRI-mediated degranulation and cytokine production in addition to the potentiation of these responses via Kit. The effect of hypothemycin on Kit-mediated responses could be explained by its inhibition of Kit kinase activity, whereas the inhibitory effects on FcepsilonRI-dependent signaling were at the level of Btk activation. Because hypothemycin also significantly reduced the mouse passive cutaneous anaphylaxis response in vivo, these data provide proof of principle for a coordinated approach for the suppression of mast cell activation and provide a rationale for the development of compounds with a similar therapeutic profile. JF - The Journal of pharmacology and experimental therapeutics AU - Jensen, Bettina M AU - Beaven, Michael A AU - Iwaki, Shoko AU - Metcalfe, Dean D AU - Gilfillan, Alasdair M AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C206, 10 Center Drive, MSC 1881, Bethesda, MD 20892-1881, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 128 EP - 138 VL - 324 IS - 1 KW - Benzamides KW - 0 KW - Cytokines KW - Piperazines KW - Pyrimidines KW - Receptors, IgE KW - Stem Cell Factor KW - hypothemycin KW - Immunoglobulin E KW - 37341-29-0 KW - Zearalenone KW - 5W827M159J KW - Imatinib Mesylate KW - 8A1O1M485B KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Zearalenone -- pharmacology KW - Humans KW - Cytokines -- immunology KW - Pyrimidines -- pharmacology KW - Calcium -- immunology KW - Mice KW - Zearalenone -- analogs & derivatives KW - Piperazines -- pharmacology KW - Mice, Inbred BALB C KW - Anaphylaxis -- immunology KW - Cell Degranulation -- drug effects KW - Immunoglobulin E -- immunology KW - Anaphylaxis -- chemically induced KW - Anaphylaxis -- prevention & control KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Stem Cell Factor -- immunology KW - Receptors, IgE -- immunology KW - Receptors, IgE -- antagonists & inhibitors KW - Mast Cells -- physiology KW - Stem Cell Factor -- antagonists & inhibitors KW - Mast Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70159190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Concurrent+inhibition+of+kit-+and+FcepsilonRI-mediated+signaling%3A+coordinated+suppression+of+mast+cell+activation.&rft.au=Jensen%2C+Bettina+M%3BBeaven%2C+Michael+A%3BIwaki%2C+Shoko%3BMetcalfe%2C+Dean+D%3BGilfillan%2C+Alasdair+M&rft.aulast=Jensen&rft.aufirst=Bettina&rft.date=2008-01-01&rft.volume=324&rft.issue=1&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-18 N1 - Date created - 2007-12-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Drugs Dermatol. 2006 Feb;5(2):117-22 [16485879] Int J Biochem Cell Biol. 1999 Oct;31(10):1053-74 [10582339] Eur J Pharmacol. 2006 Mar 8;533(1-3):327-40 [16483568] Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4234-9 [16537514] J Immunol. 2006 May 1;176(9):5167-71 [16621980] Emerg Med Australas. 2006 Apr;18(2):155-69 [16669942] Lab Invest. 2006 Jun;86(6):557-65 [16607380] Mol Cancer Ther. 2006 May;5(5):1280-9 [16731761] J Allergy Clin Immunol. 2006 Jun;117(6):1214-25; quiz 1226 [16750977] Immunol Res. 2006;34(2):97-115 [16760571] Blood. 2006 Jul 1;108(1):286-91 [16434489] Leuk Res. 2006 Nov;30(11):1365-70 [16797704] Am J Respir Cell Mol Biol. 2007 Jan;36(1):43-52 [16902192] Blood. 2007 Jan 1;109(1):315-22 [16912224] Chem Commun (Camb). 2007 Jan 7;(1):22-36 [17279252] Blood. 2000 Aug 1;96(3):925-32 [10910906] Inflamm Allergy Drug Targets. 2007 Mar;6(1):57-62 [17352689] Science. 2000 Sep 15;289(5486):1938-42 [10988075] J Immunol. 2001 Apr 1;166(7):4705-12 [11254731] Nature. 2001 Jul 12;412(6843):186-90 [11449275] J Allergy Clin Immunol. 2002 Apr;109(4):658-68 [11941316] J Immunol Methods. 2002 Oct 15;268(2):239-43 [12215392] Oncogene. 2003 Feb 6;22(5):660-4 [12569358] J Biol Chem. 2003 Nov 28;278(48):48474-84 [13129935] Trends Immunol. 2004 May;25(5):266-73 [15099567] Blood. 2004 Jul 1;104(1):207-14 [15010370] J Allergy Clin Immunol. 2004 Jul;114(1):52-7 [15241344] J Allergy Clin Immunol. 2004 Sep;114(3):527-30 [15356552] Blood. 2004 Oct 15;104(8):2410-7 [15217825] Nature. 2004 Oct 21;431(7011):1007-11 [15496927] J Exp Med. 1992 Jan 1;175(1):237-44 [1370529] J Immunol. 1997 Feb 1;158(3):1438-45 [9013989] Physiol Rev. 1997 Oct;77(4):1033-79 [9354811] J Exp Med. 1998 Apr 20;187(8):1235-47 [9547335] J Immunol. 1999 May 1;162(9):5624-30 [10228046] Blood. 1999 Oct 1;94(7):2333-42 [10498605] Am J Respir Crit Care Med. 2005 Jan 1;171(1):35-9 [15374841] Nat Immunol. 2005 Feb;6(2):135-42 [15662442] Blood. 2005 Mar 15;105(6):2473-9 [15572591] Blood. 2005 Jul 15;106(2):721-4 [15790786] Mol Cancer Ther. 2005 Aug;4(8):1186-97 [16093434] Biochem Biophys Res Commun. 2005 Nov 11;337(1):1-13 [16129412] Biochem Biophys Res Commun. 2005 Dec 23;338(3):1307-15 [16226710] J Biol Chem. 2005 Dec 2;280(48):40261-70 [16176929] Cancer Res. 2006 Jan 1;66(1):473-81 [16397263] Blood. 2006 Jan 15;107(2):610-8 [16174756] Blood. 2006 Jan 15;107(2):752-9 [16189265] Nat Rev Immunol. 2006 Mar;6(3):218-30 [16470226] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. AN - 70156397; 17895404 AB - FCRL1 (Fc receptor-like 1) is a cell-surface membrane protein belonging to FCRL family and is preferentially expressed on B cells. To evaluate FcRL1 as an immunotherapy target for B-cell malignancies, we prepared anti-FCRL1 mAbs without cross-reactivity to other FCRL family proteins and analyzed FCRL1 protein expression on malignant cells from patients and on B-cell lines. Frequent FCRL1 expression was observed by flow cytometry on 12 B-cell non-Hodgkin lymphoma (B-NHL) cell lines and many patient samples: 12 of 14 chronic lymphocytic leukemia (CLL), 7 of 7 follicular lymphoma (FL), 13 of 17 hairy cell leukemia (HCL), and 2 of 3 mantle cell lymphoma (MCL). Two recombinant immunotoxins, E3(Fv)-PE38 and E9(Fv)-PE38, were constructed. Both immunotoxins bound to FCRL1-positive cells with similar affinities (3.4 and 3.2 nM) and were cytotoxic to cell lines, but E9(Fv)-PE38 was 4- to 20-fold more cytotoxic than E3(Fv)-PE38. The concentrations that inhibited response by 50% (IC(50)s) of E9(Fv)-PE38 on 11 different FCRL1-positive cell lines ranged from 1.0 ng/mL to 90 ng/mL and correlated with the FCRL1 expression levels. Our results suggest that anti-FCRL1 immunotoxin E9(Fv)-PE38 exhibits remarkably specific cytotoxicity and merits further evaluation for the treatment of FCRL1-positive malignancies, including CLL, HCL, FL, MCL, and other B-NHL. JF - Blood AU - Du, Xing AU - Nagata, Satoshi AU - Ise, Tomoko AU - Stetler-Stevenson, Maryalice AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 338 EP - 343 VL - 111 IS - 1 SN - 0006-4971, 0006-4971 KW - Antibodies, Monoclonal KW - 0 KW - FCRLA protein, human KW - Immunotoxins KW - Receptors, Immunologic KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - B-Lymphocytes -- cytology KW - Humans KW - Mice KW - B-Lymphocytes -- immunology KW - Cell Line, Tumor KW - Antibodies, Monoclonal -- pharmacology KW - Mice, Inbred BALB C KW - Antibodies, Monoclonal -- immunology KW - Antibody Specificity KW - Immunotoxins -- immunology KW - In Vitro Techniques KW - Immunotoxins -- pharmacology KW - Female KW - Receptors, Immunologic -- immunology KW - Lymphoma, Non-Hodgkin -- therapy KW - Lymphoma, B-Cell -- therapy KW - Lymphoma, B-Cell -- immunology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- immunology KW - Immunotherapy KW - Leukemia, Hairy Cell -- therapy KW - Lymphoma, Non-Hodgkin -- immunology KW - Leukemia, Lymphocytic, Chronic, B-Cell -- therapy KW - Leukemia, Hairy Cell -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70156397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=FCRL1+on+chronic+lymphocytic+leukemia%2C+hairy+cell+leukemia%2C+and+B-cell+non-Hodgkin+lymphoma+as+a+target+of+immunotoxins.&rft.au=Du%2C+Xing%3BNagata%2C+Satoshi%3BIse%2C+Tomoko%3BStetler-Stevenson%2C+Maryalice%3BPastan%2C+Ira&rft.aulast=Du&rft.aufirst=Xing&rft.date=2008-01-01&rft.volume=111&rft.issue=1&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] Blood. 2002 Apr 15;99(8):2662-9 [11929751] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9772-7 [11493702] Genes Chromosomes Cancer. 2002 Feb;33(2):217-24 [11793449] Clin Cancer Res. 2002 Jul;8(7):2345-55 [12114439] Genes Chromosomes Cancer. 2003 Apr;36(4):375-81 [12619161] Cancer Genet Cytogenet. 2003 Jul 1;144(1):83-4 [12810263] J Immunol Methods. 2003 Sep;280(1-2):59-72 [12972188] Blood. 2003 Nov 15;102(10):3684-92 [12881317] Methods Mol Biol. 2004;248:503-18 [14970517] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3937-42 [15217923] J Immunol Methods. 2004 Sep;292(1-2):141-55 [15350519] J Immunol Methods. 1985 Mar 18;77(2):305-19 [3981007] Hybridoma. 1991 Jun;10(3):369-78 [1655635] Blood. 1997 Sep 1;90(5):2020-6 [9292538] Cytometry. 1997 Oct 15;30(5):236-44 [9383097] Immunol Rev. 1998 Apr;162:281-92 [9602371] Blood. 2005 Feb 1;105(3):1121-6 [15479727] Clin Cancer Res. 2005 Jan 1;11(1):87-96 [15671532] Haematologica. 2005 Mar;90(3):341-7 [15749666] Cytometry B Clin Cytom. 2005 Sep;67(1):6-12 [15973700] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Nat Immunol. 2006 May;7(5):431-2 [16622424] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Int Immunol. 2006 Sep;18(9):1363-73 [16849395] N Engl J Med. 2006 Sep 7;355(10):1018-28 [16908486] Leukemia. 2007 Jan;21(1):169-74 [17051241] Annu Rev Med. 2007;58:221-37 [17059365] Annu Rev Immunol. 2007;25:525-60 [17201682] J Immunother. 2007 Sep;30(6):607-13 [17667524] Immunity. 2001 Mar;14(3):277-89 [11290337] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drosophila telomeres: an exception providing new insights. AN - 70156358; 18081009 AB - Drosophila telomeres comprise DNA sequences that differ dramatically from those of other eukaryotes. Telomere functions, however, are similar to those found in telomerase-based telomeres, even though the underlying mechanisms may differ. Drosophila telomeres use arrays of retrotransposons to maintain chromosome length, while nearly all other eukaryotes rely on telomerase-generated short repeats. Regardless of the DNA sequence, several end-binding proteins are evolutionarily conserved. Away from the end, the Drosophila telomeric and subtelomeric DNA sequences are complexed with unique combinations of proteins that also modulate chromatin structure elsewhere in the genome. Maintaining and regulating the transcriptional activity of the telomeric retrotransposons in Drosophila requires specific chromatin structures and, while telomeric silencing spreads from the terminal repeats in yeast, the source of telomeric silencing in Drosophila is the subterminal arrays. However, the subterminal arrays in both species may be involved in telomere-telomere associations and/or communication. (c) 2007 Wiley Periodicals, Inc. JF - BioEssays : news and reviews in molecular, cellular and developmental biology AU - Mason, James M AU - Frydrychova, Radmila Capkova AU - Biessmann, Harald AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 25 EP - 37 VL - 30 IS - 1 SN - 0265-9247, 0265-9247 KW - DNA-Binding Proteins KW - 0 KW - Polycomb-Group Proteins KW - Repressor Proteins KW - Retroelements KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Gene Silencing KW - Retroelements -- physiology KW - Models, Biological KW - Evolution, Molecular KW - Retroelements -- genetics KW - Repressor Proteins -- physiology KW - Chromosomes -- metabolism KW - Repetitive Sequences, Nucleic Acid -- genetics KW - Mutagenesis, Insertional KW - DNA-Binding Proteins -- metabolism KW - Telomere -- physiology KW - Telomere -- metabolism KW - Drosophila -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70156358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioEssays+%3A+news+and+reviews+in+molecular%2C+cellular+and+developmental+biology&rft.atitle=Drosophila+telomeres%3A+an+exception+providing+new+insights.&rft.au=Mason%2C+James+M%3BFrydrychova%2C+Radmila+Capkova%3BBiessmann%2C+Harald&rft.aulast=Mason&rft.aufirst=James&rft.date=2008-01-01&rft.volume=30&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=BioEssays+%3A+news+and+reviews+in+molecular%2C+cellular+and+developmental+biology&rft.issn=02659247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-27 N1 - Date created - 2007-12-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Cell Biol. 2005 Aug;83(4):477-85 [16094451] Chromosome Res. 2005;13(5):443-53 [16132810] Chromosome Res. 2005;13(5):455-67 [16132811] Chromosoma. 2005 Aug;114(3):135-45 [16012858] Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15167-72 [16203987] J Cell Sci. 2005 Dec 1;118(Pt 23):5465-77 [16278293] Mol Cell. 2005 Dec 22;20(6):821-31 [16364909] J Biol Chem. 2003 Sep 5;278(36):34491-8 [12826664] Annu Rev Genet. 2003;37:485-511 [14616071] Cell Mol Life Sci. 2003 Nov;60(11):2319-24 [14625678] Cell Mol Life Sci. 2003 Nov;60(11):2325-33 [14625679] Trends Genet. 2004 Apr;20(4):214-20 [15041176] Genome. 2004 Feb;47(1):163-78 [15060613] DNA Repair (Amst). 2004 Jun 3;3(6):603-15 [15135728] Genes Dev. 2004 Aug 1;18(15):1850-61 [15256487] Curr Biol. 2004 Aug 10;14(15):1341-7 [15296750] Curr Biol. 2004 Aug 10;14(15):1348-53 [15296751] Curr Biol. 2004 Aug 10;14(15):1354-9 [15296752] Curr Biol. 2004 Aug 10;14(15):1360-6 [15296753] Mol Biol Evol. 2004 Sep;21(9):1613-9 [15163766] Mol Cell. 2004 Aug 13;15(3):467-76 [15304225] Mol Genet Genomics. 2004 Oct;272(3):336-43 [15372228] Nat New Biol. 1972 Oct 18;239(94):197-201 [4507727] J Theor Biol. 1973 Sep 14;41(1):181-90 [4754905] Proc Natl Acad Sci U S A. 1984 Oct;81(19):6090-4 [6435123] EMBO J. 1988 Apr;7(4):1081-6 [2841109] Gene. 1999 Jun 11;233(1-2):249-59 [10375642] Chromosoma. 1999 May;108(2):114-20 [10382073] Cell. 1997 Mar 7;88(5):647-55 [9054504] Nucleic Acids Res. 1997 Apr 15;25(8):1578-84 [9092665] Genes Dev. 1997 Apr 1;11(7):863-75 [9106658] Genetics. 1997 Aug;146(4):1381-97 [9258681] Trends Genet. 1997 Dec;13(12):489-96 [9433139] Curr Opin Genet Dev. 1997 Dec;7(6):822-8 [9468793] Genetics. 1998 Jan;148(1):233-42 [9475735] Genetics. 1998 Feb;148(2):775-92 [9504924] Curr Opin Genet Dev. 1998 Apr;8(2):147-53 [9610404] Chromosome Res. 1998 Jun;6(4):315-21 [9688522] Mol Cell. 1998 Nov;2(5):527-38 [9844626] Chromosoma. 1998 Nov;107(5):311-20 [9880764] Genetics. 1999 Mar;151(3):1041-51 [10049921] Chromosome Res. 1999;7(6):449-60 [10560968] Genetics. 2000 Aug;155(4):1841-54 [10924479] Mol Cell Biol. 2000 Oct;20(20):7634-42 [11003659] Mol Biol Cell. 2001 Jun;12(6):1671-85 [11408576] Proc Natl Acad Sci U S A. 1988 Nov;85(21):8116-20 [3141921] Cell. 1989 Aug 25;58(4):791-801 [2548737] Proc Natl Acad Sci U S A. 1990 Mar;87(5):1758-61 [2308935] EMBO J. 1992 Dec;11(12):4459-69 [1330538] Genetics. 2004 Nov;168(3):1353-70 [15579690] Mol Genet Genomics. 2004 Dec;272(5):512-8 [15503143] Genetics. 2005 Jan;169(1):173-84 [15371351] Genetics. 2005 May;170(1):221-35 [15781709] Bioessays. 2005 Jul;27(7):685-97 [15954099] Genetics. 2005 Dec;171(4):1767-77 [16143601] Genes Dev. 2006 Feb 1;20(3):345-54 [16452506] Mol Biol Cell. 2006 May;17(5):2158-65 [16495335] PLoS Genet. 2006 May;2(5):e71 [16710445] Chromosome Res. 2006;14(4):377-92 [16821134] Genetics. 2006 Jul;173(3):1447-54 [16648644] Genome Res. 2006 Oct;16(10):1231-40 [16963706] Annu Rev Cell Dev Biol. 2006;22:531-57 [16824017] DNA Repair (Amst). 2006 Nov 8;5(11):1299-306 [16798109] Chromosoma. 2006 Dec;115(6):413-25 [16741708] Annu Rev Entomol. 2007;52:171-92 [16881818] Chromosoma. 2007 Feb;116(1):41-51 [17089138] Nature. 2007 Mar 8;446(7132):208-12 [17344853] Chromosoma. 2007 Apr;116(2):185-95 [17186256] Nat Rev Genet. 2007 Apr;8(4):299-309 [17363977] Dev Cell. 2007 Jun;12(6):863-72 [17543860] Mol Cell Biol. 2007 Jul;27(13):4991-5001 [17470550] Genetics. 2001 Jul;158(3):1111-23 [11454760] Genetics. 2002 Jan;160(1):235-45 [11805059] Oncogene. 2002 Jan 21;21(4):522-31 [11850777] Chromosome Res. 2002;10(1):21-31 [11863067] Adv Genet. 2002;46:421-38 [11931233] Mol Cell Biol. 2002 May;22(9):3204-18 [11940677] Genome Biol. 2002 Sep 27;3(10):REVIEWS0007 [12372147] J Cell Biol. 2002 Nov 11;159(3):397-402 [12417578] Genetics. 2002 Nov;162(3):1301-12 [12454074] Nat Cell Biol. 2003 Jan;5(1):82-4 [12510197] Genetics. 2003 Mar;163(3):917-30 [12663532] Genetics. 2003 Apr;163(4):1375-87 [12702682] Genetica. 2003 Mar;117(2-3):311-8 [12723710] Genetics. 2003 May;164(1):195-208 [12750332] FEBS Lett. 1999 Jun 18;453(1-2):59-62 [10403375] Nat Struct Mol Biol. 2004 Nov;11(11):1076-83 [15475964] Genetics. 1992 Nov;132(3):737-53 [1334894] Genetics. 1993 Feb;133(2):347-59 [8382177] Chromosoma. 1993 May;102(5):297-305 [8391971] Cell. 1993 Dec 17;75(6):1083-93 [8261510] Chromosoma. 1994 Apr;103(2):90-8 [8055715] Trends Genet. 1995 Feb;11(2):58-62 [7716808] Genes Dev. 1995 May 15;9(10):1263-77 [7758950] EMBO J. 1995 Aug 15;14(16):3977-86 [7664737] Chromosoma. 1995 Dec;104(4):229-41 [8565699] Genetics. 1995 Nov;141(3):1061-74 [8582613] Insect Mol Biol. 1996 Feb;5(1):11-20 [8630530] Genes Dev. 1996 Jun 1;10(11):1310-26 [8647430] Annu Rev Genet. 1995;29:577-605 [8825487] Cell. 1996 Nov 29;87(5):917-27 [8945518] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotinamide uncouples hormone-dependent chromatin remodeling from transcription complex assembly. AN - 70155076; 17954562 AB - Sirtuins, homologs of the yeast SIR2 family, are protein deacetylases that require nicotinamide adenosine dinucleotide as cofactor. To determine whether the sirtuin family of deacetylases is involved in progesterone receptor (PR)-mediated transcription, the effect of sirtuin inhibitor, nicotinamide (NAM), was monitored in T47D breast cancer cells. NAM suppressed hormone-dependent activation of PR-regulated genes in a dose-dependent manner. Surprisingly, NAM-mediated inhibition of PR-mediated transcription occurs independently of SIRT1 and PARP1. Chromatin immunoprecipitation experiments did not show that PR binding nor that of the coactivators CBP and SRC3 was compromised. Consistent with the recruitment of the BRG1 chromatin remodeling complex, promoter chromatin remodeling still occurs despite NAM inhibition of PR transactivation. Rather, we show that this inhibition of transcription is due to dramatic loss of recruitment of the basal transcriptional machinery to the promoter. These results show that NAM uncouples promoter chromatin remodeling from transcription preinitiation complex assembly and suggest the existence of vital NAM-regulated steps required for promoter chromatin remodeling and basal transcription complex communication. JF - Molecular and cellular biology AU - Aoyagi, Sayura AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, NIEHS/NIH, 111 Alexander Drive, P.O. Box 12233 (MD D4-01), Research Triangle Park, NC 27709, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 30 EP - 39 VL - 28 IS - 1 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Hormones KW - MED14 protein, human KW - Mediator Complex KW - NEDD9 protein, human KW - Phosphoproteins KW - Receptors, Glucocorticoid KW - Receptors, Progesterone KW - Trans-Activators KW - Niacinamide KW - 25X51I8RD4 KW - PARP1 protein, human KW - EC 2.4.2.30 KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerases KW - Endodeoxyribonucleases KW - EC 3.1.- KW - MBD4 protein, human KW - SIRT1 protein, human KW - EC 3.5.1.- KW - Sirtuin 1 KW - Sirtuins KW - Index Medicus KW - Trans-Activators -- metabolism KW - Phosphoproteins -- genetics KW - Humans KW - Endodeoxyribonucleases -- genetics KW - Cell Line, Tumor KW - Endodeoxyribonucleases -- metabolism KW - Receptors, Glucocorticoid -- metabolism KW - Protein Binding KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Sirtuins -- metabolism KW - Poly(ADP-ribose) Polymerases -- genetics KW - Receptors, Progesterone -- metabolism KW - Trans-Activators -- genetics KW - Sirtuins -- genetics KW - Adaptor Proteins, Signal Transducing -- genetics KW - Promoter Regions, Genetic -- genetics KW - Gene Expression Regulation KW - Phosphoproteins -- metabolism KW - Niacinamide -- pharmacology KW - Transcription, Genetic -- drug effects KW - Chromatin Assembly and Disassembly -- genetics KW - Transcription, Genetic -- genetics KW - Chromatin Assembly and Disassembly -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70155076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Nicotinamide+uncouples+hormone-dependent+chromatin+remodeling+from+transcription+complex+assembly.&rft.au=Aoyagi%2C+Sayura%3BArcher%2C+Trevor+K&rft.aulast=Aoyagi&rft.aufirst=Sayura&rft.date=2008-01-01&rft.volume=28&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-11 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 2006 Sep 15;23(6):809-18 [16973433] Mol Cell Biol. 2006 Nov;26(21):8122-35 [16923962] Mol Cell Biol. 1994 Jan;14(1):32-41 [8264599] Annu Rev Biochem. 1994;63:451-86 [7979245] Mol Cell Biol. 1995 Jan;15(1):26-34 [7799933] Mol Endocrinol. 1994 Sep;8(9):1154-62 [7838148] Mol Cell Biol. 1996 Jan;16(1):281-7 [8524305] Cell. 1995 Dec 15;83(6):835-9 [8521507] Nature. 1997 Jun 12;387(6634):733-6 [9192902] Nature. 1998 May 7;393(6680):88-91 [9590696] Genes Dev. 1998 Jun 15;12(12):1787-800 [9637681] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7939-44 [9653119] Nature. 1999 Apr 29;398(6730):824-8 [10235266] Cell. 1999 Sep 3;98(5):675-86 [10490106] EMBO J. 1999 Oct 1;18(19):5380-8 [10508170] Cell. 2004 Dec 17;119(6):803-14 [15607977] Vitam Horm. 2005;70:281-307 [15727808] Nature. 2005 Mar 3;434(7029):113-8 [15744310] J Biol Chem. 2005 Mar 18;280(11):10264-76 [15632193] Mol Cell. 2005 Mar 18;17(6):855-68 [15780941] Mol Cell. 2005 Apr 1;18(1):83-96 [15808511] J Biol Chem. 2005 Apr 22;280(16):16456-60 [15716268] Trends Biochem Sci. 2005 May;30(5):235-9 [15896740] Trends Biochem Sci. 2005 May;30(5):250-5 [15896743] Trends Biochem Sci. 2005 May;30(5):256-63 [15896744] Nat Rev Mol Cell Biol. 2005 Jul;6(7):542-54 [15957004] Trends Biochem Sci. 2005 Sep;30(9):479-83 [16039130] Genes Dev. 2005 Sep 1;19(17):1951-67 [16140981] Curr Opin Chem Biol. 2005 Oct;9(5):431-40 [16122969] Mol Biol Cell. 2005 Oct;16(10):4623-35 [16079181] Cell. 2006 Jan 27;124(2):315-29 [16439206] EMBO Rep. 2006 Feb;7(2):161-7 [16452926] Mol Endocrinol. 2006 Mar;20(3):560-72 [16239257] Curr Med Chem. 2006;13(8):883-95 [16611073] Biomed Pharmacother. 2006 Nov;60(9):520-8 [16949786] Genes Dev. 2006 Nov 1;20(21):2913-21 [17079682] Nature. 2000 Feb 17;403(6771):795-800 [10693811] Science. 2001 Nov 30;294(5548):1866-70 [11729302] J Biol Chem. 2002 Feb 15;277(7):5209-18 [11717311] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2642-7 [11867769] Genes Dev. 2002 Jul 15;16(14):1852-63 [12130544] EMBO J. 2002 Aug 1;21(15):4094-103 [12145209] J Biol Chem. 2002 Nov 8;277(45):42852-8 [12218053] Chromosoma. 2003 May;111(8):495-504 [12743713] Mol Cell Biol. 2003 Jun;23(11):3763-73 [12748280] Recent Prog Horm Res. 2003;58:199-226 [12795420] J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):139-45 [12943698] Cell Mol Life Sci. 2004 Jan;61(1):19-34 [14704851] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):30-45 [15020043] Mol Cell Biol. 2004 Apr;24(8):3347-58 [15060156] Mol Cell. 2004 Jun 4;14(5):553-7 [15175151] Annu Rev Biochem. 2004;73:417-35 [15189148] Nature. 2004 Jun 17;429(6993):771-6 [15175761] Mol Cell. 2004 Oct 8;16(1):93-105 [15469825] Mol Endocrinol. 1989 Aug;3(8):1270-8 [2550815] Rev Physiol Biochem Pharmacol. 2006;156:23-43 [16634145] Genes Dev. 2006 May 1;20(9):1075-80 [16618798] Genes Dev. 2006 May 15;20(10):1256-61 [16648462] Genes Dev. 2006 Jun 1;20(11):1405-28 [16751179] Science. 2006 Jun 23;312(5781):1798-802 [16794079] Mol Endocrinol. 2006 Jul;20(7):1479-93 [16497729] Trends Biochem Sci. 2007 Jan;32(1):12-9 [17161604] Mol Endocrinol. 2007 Apr;21(4):843-56 [17227884] Trends Endocrinol Metab. 2006 Jul;17(5):186-91 [16684606] Crit Rev Biochem Mol Biol. 2006 May-Jun;41(3):105-78 [16858867] Exp Gerontol. 2006 Aug;41(8):718-26 [16842957] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Non-homologous end joining is important for repair of Cr(VI)-induced DNA damage in Saccharomyces cerevisiae. AN - 70154516; 17923397 AB - Hexavalent chromium is known to be a potent carcinogen that leads to many different DNA lesions, including DNA-protein crosslinks, and single- and double-strand breaks. In Saccharomyces cerevisiae, DNA double-strand breaks are mainly repaired by either homologous recombination (HR) or non-homologous end-joining (NHEJ) repair pathways. Here, we show that mutants deficient in NHEJ (yku70Delta, rad50Delta, dnl4Delta, mre11Delta, xrs2Delta) of S. cerevisiae are more sensitive to Cr(VI) toxic effects than wild-type cells. Also, a deletion mutant of SAE2 showed a similar sensitivity to Cr(VI), even though it has no apparent direct role in NHEJ. We also found that double mutants in HR and NHEJ (yku70Delta/rad52Delta, rad50Delta/rad52Delta, dnl4Delta/rad52Delta, mre11Delta/rad52Delta, xrs2Delta/rad52Delta) are synergistically more sensitive to Cr(VI) exposure than any of the single mutants, indicating that both repair pathways are involved in the repair of Cr(VI)-induced lesions. Finally, when the NHEJ mutants were exposed to Cr(VI) under anaerobic growth conditions, Cr(VI) toxicity was suppressed. JF - Microbiological research AU - Santoyo, Gustavo AU - Strathern, Jeffrey N AD - Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA. gustavo_santoyo@yahoo.com Y1 - 2008 PY - 2008 DA - 2008 SP - 113 EP - 119 VL - 163 IS - 1 SN - 0944-5013, 0944-5013 KW - DNA, Fungal KW - 0 KW - SAE2 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - Chromium KW - 0R0008Q3JB KW - Endonucleases KW - EC 3.1.- KW - Index Medicus KW - Saccharomyces cerevisiae Proteins -- genetics KW - Mutation KW - Anaerobiosis KW - Chromosome Breakage KW - Saccharomyces cerevisiae -- genetics KW - DNA Repair -- genetics KW - Saccharomyces cerevisiae -- growth & development KW - Recombination, Genetic KW - DNA, Fungal -- genetics KW - DNA Breaks, Double-Stranded KW - Chromium -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70154516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiological+research&rft.atitle=Non-homologous+end+joining+is+important+for+repair+of+Cr%28VI%29-induced+DNA+damage+in+Saccharomyces+cerevisiae.&rft.au=Santoyo%2C+Gustavo%3BStrathern%2C+Jeffrey+N&rft.aulast=Santoyo&rft.aufirst=Gustavo&rft.date=2008-01-01&rft.volume=163&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Microbiological+research&rft.issn=09445013&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-13 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mouse model of heterotaxy with single ventricle spectrum of cardiac anomalies. AN - 70154003; 18043505 AB - Heterotaxy arises from a failure of the embryo to establish normal left-right asymmetry and is known to affect 3% of infants with congenital heart disease. A recessive mutation causing heterotaxy was recovered in a mouse mutagenesis screen focused on congenital heart defects. Homozygote mutants exhibit abnormal situs in the thoracic and abdominal cavities. Dextrocardia, levocardia, or mesocardia was seen together with right pulmonary isomerism and complex structural heart defects in the single ventricle spectrum. A dominant chamber of left ventricular morphology positioned on the left or right is seen together with transposition of the great arteries. Right atrial isomerism with or without total anomalous pulmonary venous connection was observed in half of the mutants. Because ciliary motion at the embryonic node is required for the specification of laterality, we examined the tracheal epithelia of newborn mice as a proxy for the nodal cilia. However, videomicroscopy showed no defect in ciliary motion. Genome scanning using polymorphic microsatellite markers mapped the mutation to a 3.3 Mb interval on mouse chromosome 7. None of the genes previously described for familial heterotaxy were found in this interval, indicating a novel mutation in this mouse model of heterotaxy. JF - Pediatric research AU - Aune, Christine N AU - Chatterjee, Bishwanath AU - Zhao, Xiao-Qing AU - Francis, Richard AU - Bracero, Luciann AU - Yu, Qing AU - Rosenthal, Julie AU - Leatherbury, Linda AU - Lo, Cecilia W AD - Laboratory of Developmental Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 9 EP - 14 VL - 63 IS - 1 SN - 0031-3998, 0031-3998 KW - Index Medicus KW - Animals KW - Polydactyly -- genetics KW - Microscopy, Video KW - Cilia -- pathology KW - Dextrocardia -- pathology KW - Disease Models, Animal KW - Chromosome Mapping KW - Microscopy, Fluorescence KW - Phenotype KW - Imaging, Three-Dimensional KW - Transposition of Great Vessels -- genetics KW - Mice, Inbred C3H KW - Heart Ventricles -- abnormalities KW - Dextrocardia -- genetics KW - Image Interpretation, Computer-Assisted KW - Homozygote KW - Levocardia -- genetics KW - Levocardia -- pathology KW - Polydactyly -- pathology KW - Mice KW - Pulmonary Veins -- abnormalities KW - Transposition of Great Vessels -- pathology KW - Respiratory Mucosa -- pathology KW - Animals, Newborn KW - Mice, Inbred C57BL KW - Heart Atria -- pathology KW - Abnormalities, Multiple -- genetics KW - Abnormalities, Multiple -- embryology KW - Heart Defects, Congenital -- embryology KW - Heart Defects, Congenital -- pathology KW - Abnormalities, Multiple -- pathology KW - Mutation KW - Chromosomes, Mammalian KW - Heart Defects, Congenital -- genetics KW - Body Patterning -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70154003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+research&rft.atitle=Mouse+model+of+heterotaxy+with+single+ventricle+spectrum+of+cardiac+anomalies.&rft.au=Aune%2C+Christine+N%3BChatterjee%2C+Bishwanath%3BZhao%2C+Xiao-Qing%3BFrancis%2C+Richard%3BBracero%2C+Luciann%3BYu%2C+Qing%3BRosenthal%2C+Julie%3BLeatherbury%2C+Linda%3BLo%2C+Cecilia+W&rft.aulast=Aune&rft.aufirst=Christine&rft.date=2008-01-01&rft.volume=63&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Pediatric+research&rft.issn=00313998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-07 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mesothelin targeted cancer immunotherapy. AN - 70150091; 17945478 AB - Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium. It is, however, highly expressed in several human cancers including malignant mesothelioma, pancreatic, ovarian and lung adenocarcinoma. The normal biologic function of mesothelin is unknown but recent studies have shown that it binds to CA-125 and may play a role in the peritoneal spread of ovarian cancer. The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy. Three mesothelin targeted agents are in various stages of clinical evaluation in patients. These include SS1P (CAT-5001) a recombinant immunotoxin targeting mesothelin, MORAb-009 a chimeric anti-mesothelin monoclonal antibody and CRS-207 a live-attenuated Listeria monocytogenes vector encoding human mesothelin. These ongoing clinical trials will help define the utility of mesothelin as a target for cancer therapy. JF - European journal of cancer (Oxford, England : 1990) AU - Hassan, Raffit AU - Ho, Mitchell AD - Solid Tumor Immunotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4264, USA. hassanr@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 46 EP - 53 VL - 44 IS - 1 SN - 0959-8049, 0959-8049 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - Cancer Vaccines KW - GPI-Linked Proteins KW - MORAb-009 monoclonal antibody KW - Membrane Glycoproteins KW - SS1(dsFv)PE38 KW - mesothelin KW - Index Medicus KW - Listeria monocytogenes KW - Humans KW - Genetic Vectors -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology KW - Neoplasms -- drug therapy KW - Membrane Glycoproteins -- drug effects KW - Antineoplastic Agents -- immunology KW - Antineoplastic Agents -- therapeutic use KW - Membrane Glycoproteins -- immunology KW - Neoplasms -- immunology KW - Membrane Glycoproteins -- metabolism KW - Immunotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70150091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=Mesothelin+targeted+cancer+immunotherapy.&rft.au=Hassan%2C+Raffit%3BHo%2C+Mitchell&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2008-01-01&rft.volume=44&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=09598049&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-14 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Gynecol Oncol. 2007 Jun;105(3):563-70 [17400285] Cancer Res. 2003 Aug 1;63(15):4547-51 [12907630] Am J Surg Pathol. 2003 Nov;27(11):1418-28 [14576474] BMC Dev Biol. 2003 Apr 7;3:2 [12697065] Lancet. 2003 Nov 15;362(9396):1612-6 [14630441] J Biol Chem. 2004 Mar 5;279(10):9190-8 [14676194] Hum Pathol. 2004 Mar;35(3):357-66 [15017593] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):3937-42 [15217923] Anticancer Res. 2004 May-Jun;24(3a):1327-35 [15274292] J Exp Med. 2004 Aug 2;200(3):297-306 [15289501] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13832-7 [15365184] N Engl J Med. 1983 Oct 13;309(15):883-7 [6310399] Int J Cancer. 1992 Feb 1;50(3):373-81 [1735605] Am J Surg Pathol. 1992 Mar;16(3):259-68 [1599018] Int J Cancer. 1992 Jun 19;51(4):548-54 [1351045] J Biol Chem. 1994 Jan 14;269(2):805-8 [8288629] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):136-40 [8552591] Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):669-74 [9435250] Nat Biotechnol. 1999 Jun;17(6):568-72 [10385321] Gene Ther. 2005 Jan;12(2):187-93 [15526007] Clin Cancer Res. 2005 May 15;11(10):3814-20 [15897581] J Nucl Med. 2005 Jul;46(7):1201-9 [16000290] Appl Immunohistochem Mol Morphol. 2005 Sep;13(3):243-7 [16082249] Clin Cancer Res. 2005 Sep 1;11(17):6342-51 [16144939] Am J Clin Pathol. 2005 Dec;124(6):838-45 [16416732] Clin Cancer Res. 2006 Jan 15;12(2):447-53 [16428485] Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):827-31 [16467095] Clin Cancer Res. 2006 Aug 1;12(15):4695-701 [16899620] Clin Cancer Res. 2006 Aug 15;12(16):4983-8 [16914588] Mol Cancer. 2006;5(1):50 [17067392] Hum Pathol. 2007 Jan;38(1):1-16 [17056092] Clin Cancer Res. 2007 Mar 1;13(5):1571-5 [17332303] Oncogene. 1999 Dec 20;18(55):7860-72 [10630639] Mol Cell Biol. 2000 Apr;20(8):2902-6 [10733593] J Clin Oncol. 2001 Jan 1;19(1):145-56 [11134207] J Biol Chem. 2001 Jul 20;276(29):27371-5 [11369781] Clin Cancer Res. 2001 Dec;7(12):3862-8 [11751476] Clin Cancer Res. 2002 Nov;8(11):3520-6 [12429643] Am J Surg Pathol. 2003 Feb;27(2):150-8 [12548160] Mod Pathol. 2003 Mar;16(3):192-7 [12640097] Clin Cancer Res. 2007 Sep 1;13(17):5144-9 [17785569] Hum Pathol. 2003 Jun;34(6):605-9 [12827615] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - NMDA and non-NMDA receptor-mediated differential Ca2+ load and greater vulnerability of motor neurons in spinal cord cultures. AN - 70146919; 17692996 AB - Glutamate receptor activated neuronal cell death has been implicated in the pathogenesis of motor neuron disease but the molecular mechanism responsible for neuronal dysfunction needs to be elucidated. In the present study, we examined the contribution of NMDA and non-NMDA sub-types of glutamate receptors in selective vulnerability of motor neurons. Glutamate receptor activated Ca2+ signaling, mitochondrial functions and neurotoxicity in motor neurons and other spinal neurons were studied in mixed spinal cord primary cultures. Exposure of cells to glutamate receptor agonists glutamate, NMDA and AMPA elevated the intracellular Ca2+, mitochondrial Ca2+ and caused mitochondrial depolarization and cytotoxicity in both motor neurons and other spinal neurons but a striking difference was observed in the magnitude and temporal patterns of the [Ca2+]i responses between the two neuronal cell types. The motor neurons elicited higher Ca2+ load than the other spinal neurons and the [Ca2+]i levels were elevated for a longer duration in motor neurons. AMPA receptor stimulation was more effective than NMDA. Both the NMDA and non-NMDA receptor antagonists APV and NBQX inhibited the Ca2+ entry and decreased the cell death significantly; however, NBQX was more potent than APV. Our results demonstrate that both NMDA and non-NMDA sub-types of glutamate receptors contribute to glutamate-mediated motor neuron damage but AMPA receptors play the major role. AMPA receptor-mediated excessive Ca2+ load and differential handling/regulation of Ca2+ buffering by mitochondria in motor neurons could be central in their selective vulnerability to excitotoxicity. JF - Neurochemistry international AU - Sen, Indrani AU - Joshi, Dinesh C AU - Joshi, Preeti G AU - Joshi, Nanda B AD - Department of Biophysics, National Institute of Mental Health and Neuro Sciences, Bangalore 560 029, India. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 247 EP - 255 VL - 52 IS - 1-2 SN - 0197-0186, 0197-0186 KW - Receptors, N-Methyl-D-Aspartate KW - 0 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Motor Neurons -- metabolism KW - Calcium -- metabolism KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Spinal Cord -- metabolism KW - Spinal Cord -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70146919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=NMDA+and+non-NMDA+receptor-mediated+differential+Ca2%2B+load+and+greater+vulnerability+of+motor+neurons+in+spinal+cord+cultures.&rft.au=Sen%2C+Indrani%3BJoshi%2C+Dinesh+C%3BJoshi%2C+Preeti+G%3BJoshi%2C+Nanda+B&rft.aulast=Sen&rft.aufirst=Indrani&rft.date=2008-01-01&rft.volume=52&rft.issue=1-2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-05 N1 - Date created - 2007-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drugs of abuse and the aging brain. AN - 70110600; 17406645 AB - Substance abuse among older adults has received little attention in the past, presumably because this population has traditionally accounted for only a small percentage of the drug abuse problem in the United States. The aging of the baby boomer generation (born 1946-1964), however, will soon swell the ranks of older adults and dramatically alter the demography of American society. Several observations suggest that this expansion will likely be accompanied by a precipitous increase in the abuse of drugs, including prescription medications and illicit substances, among older adults. While it is now evident that the brain changes continuously across life, how drugs of abuse interact with these age-related changes remains unclear. The dynamic nature of brain function, however, suggests that substance abuse during older age may augment the risks and require unique considerations for diagnosis and treatment. In addition to describing current and projected prevalence estimates of substance abuse among older adults, the present review discusses how aging affects brain systems involved in drug abuse, and explores the potential impact of drug abuse on the aging brain. Future directions for substance abuse research among older adults will also be considered. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Dowling, Gayathri J AU - Weiss, Susan R B AU - Condon, Timothy P AD - National Institute on Drug Abuse, NIH, DHHS, Bethesda, MD 20982-9591, USA. dowlingg@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 209 EP - 218 VL - 33 IS - 2 SN - 0893-133X, 0893-133X KW - Neurotoxins KW - 0 KW - Neurotransmitter Agents KW - Index Medicus KW - Neurotransmitter Agents -- therapeutic use KW - Neurotransmitter Agents -- physiology KW - Humans KW - Incidence KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Neurotransmitter Agents -- pharmacokinetics KW - Comorbidity KW - Brain -- physiopathology KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- rehabilitation KW - Brain -- growth & development KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70110600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Drugs+of+abuse+and+the+aging+brain.&rft.au=Dowling%2C+Gayathri+J%3BWeiss%2C+Susan+R+B%3BCondon%2C+Timothy+P&rft.aulast=Dowling&rft.aufirst=Gayathri&rft.date=2008-01-01&rft.volume=33&rft.issue=2&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-06 N1 - Date created - 2007-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. AN - 70106124; 17764662 AB - Family, adoption and twin data each support substantial heritability for addictions. Most of this heritable influence is not substance-specific. The overlapping genetic vulnerability for developing dependence on a variety of addictive substances suggests large roles for "higher order" pharamacogenomics in addiction molecular genetics. We and others have now completed genome-wide association (GWA) studies of DNAs from individuals with dependence on a variety of addictive substances versus appropriate controls. Recently reported replicated GWA observations identify a number of genes based on comparisons between controls and European-American and African-American polysubstance abusers. Here we review the convergence between these results and data that compares control samples and (a) alcohol-dependent European-Americans, (b) methamphetamine-dependent Asians and (c) nicotine dependent samples from European backgrounds. We also compare these human data to quantitative trait locus (QTL) results from studies of addiction-related phenotypes in mice that focus on alcohol, methamphetamine and barbiturates. These comparisons support a genetic architecture built from largely polygenic contributions of common allelic variants to dependence on a variety of legal and illegal substances. Many of the gene variants identified in this way are likely to alter specification and maintenance of neuronal connections. JF - Biochemical pharmacology AU - Uhl, George R AU - Drgon, Tomas AU - Johnson, Catherine AU - Fatusin, Oluwatosin O AU - Liu, Qing-Rong AU - Contoreggi, Carlo AU - Li, Chuan-Yun AU - Buck, Kari AU - Crabbe, John AD - Molecular Neurobiology Branch, NIH-IRP (NIDA), Suite 3510, 333 Cassell Drive Baltimore, MD 21224, USA. guhl@intra.nida.nih.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 98 EP - 111 VL - 75 IS - 1 SN - 0006-2952, 0006-2952 KW - Index Medicus KW - Phenotype KW - Animals KW - Molecular Biology KW - Association KW - Humans KW - European Continental Ancestry Group KW - Quantitative Trait Loci KW - African Americans KW - Mice KW - Genetic Predisposition to Disease KW - Species Specificity KW - Pharmacogenetics KW - Genome, Human KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70106124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=%22Higher+order%22+addiction+molecular+genetics%3A+convergent+data+from+genome-wide+association+in+humans+and+mice.&rft.au=Uhl%2C+George+R%3BDrgon%2C+Tomas%3BJohnson%2C+Catherine%3BFatusin%2C+Oluwatosin+O%3BLiu%2C+Qing-Rong%3BContoreggi%2C+Carlo%3BLi%2C+Chuan-Yun%3BBuck%2C+Kari%3BCrabbe%2C+John&rft.aulast=Uhl&rft.aufirst=George&rft.date=2008-01-01&rft.volume=75&rft.issue=1&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-26 N1 - Date created - 2007-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Mol Genet. 2007 Jan 1;16(1):24-35 [17158188] BMC Genet. 2007;8:10 [17407593] Nat Genet. 2007 May;39(5):631-7 [17401366] BMC Genet. 2005;6 Suppl 1:S143 [16451603] BMC Genet. 2005;6 Suppl 1:S30 [16451640] BMC Genet. 2005;6 Suppl 1:S31 [16451641] Am J Med Genet. 2000 Oct 9;96(5):665-70 [11054775] Genome Res. 2003 Jan;13(1):103-7 [12529312] News Physiol Sci. 2003 Aug;18:147-50 [12869614] Genes Brain Behav. 2002 Nov;1(4):242-51 [12882369] Am J Med Genet A. 2004 Jan 1;124A(1):19-27 [14679582] Alcohol Clin Exp Res. 2004 Jan;28(1):4-9 [14745296] BMC Genet. 2003;4 Suppl 1:S101 [14975169] BMC Genet. 2003;4 Suppl 1:S102 [14975170] BMC Genet. 2003;4 Suppl 1:S103 [14975171] BMC Genet. 2003;4 Suppl 1:S105 [14975173] Psychopharmacology (Berl). 2004 Mar;172(3):264-70 [14600800] Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):23-36 [15048644] Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):94-101 [15211640] Nat Neurosci. 2004 Jul;7(7):699-700 [15208631] Behav Genet. 2004 Sep;34(5):549-55 [15319578] Neuron. 2004 Sep 30;44(1):161-79 [15450168] Seishin Shinkeigaku Zasshi. 2004;106(12):1598-603 [15770963] BMC Genet. 2005;6:11 [15740611] Pharmacogenomics J. 2005;5(2):89-95 [15772696] Neuropsychopharmacology. 2005 Apr;30(4):742-6 [15508023] Mol Psychiatry. 2005 Apr;10(4):384-92 [15452586] Mutat Res. 2005 Jun 3;573(1-2):54-69 [15829237] BMC Genet. 2005;6 Suppl 1:S65 [16451678] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53 [16894614] Genet Epidemiol. 1999;17 Suppl 1:S55-60 [10597412] Genet Epidemiol. 1999;17 Suppl 1:S139-44 [10597426] Trends Cell Biol. 2000 Nov;10(11):473-82 [11050419] Am J Med Genet. 2000 Oct 9;96(5):632-7 [11054770] Am J Med Genet B Neuropsychiatr Genet. 2005 Jan 5;132B(1):70-3 [15459944] Psychol Med. 2004 Oct;34(7):1227-37 [15697049] Nat Rev Genet. 2005 Feb;6(2):95-108 [15716906] Nat Rev Genet. 2005 Feb;6(2):109-18 [15716907] Neurosci Lett. 2005 Mar 16;376(3):182-7 [15721218] BMC Genomics. 2005;6:52 [15811185] Expert Rev Mol Diagn. 2005 Mar;5(2):159-70 [15833046] Hum Mol Genet. 2005 May 15;14(10):1315-25 [15800012] Pharmacogenomics J. 2005;5(3):166-72 [15724146] Am J Psychiatry. 2005 Aug;162(8):1414-22 [16055762] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9 [16091475] Neuropsychopharmacology. 2001 Mar;24(3):291-9 [11166519] Alcohol Clin Exp Res. 2001 Mar;25(3):323-9 [11290841] Science. 2001 May 11;292(5519):1175-8 [11349151] Science. 2001 Jun 22;292(5525):2266-7 [11423644] Am J Hum Genet. 2001 Dec;69(6):1290-300 [11704927] Neuroscience. 2001;107(2):265-74 [11731100] J Stud Alcohol. 2002 Jan;63(1):74-82 [11925062] Biol Psychol. 2002 Oct;61(1-2):229-48 [12385677] Alcohol Clin Exp Res. 2002 Oct;26(10):1453-60 [12394277] Nat Rev Genet. 2002 Nov;3(11):862-71 [12415316] Physiol Behav. 2002 Nov;77(2-3):301-10 [12419406] Neuropharmacology. 2004;47 Suppl 1:140-7 [15464133] J Clin Psychiatry. 1982 Oct;43(10):415-8 [7118836] Biol Psychiatry. 1990 Jun 15;27(12):1293-304 [2364118] Am J Hum Genet. 1991 Apr;48(4):677-81 [2014795] Arch Gen Psychiatry. 1992 Sep;49(9):723-7 [1355337] Lancet. 1994 Mar 19;343(8899):741-2 [7907720] J Stud Alcohol. 1994 Mar;55(2):149-58 [8189735] Nat Genet. 1994 May;7(1):54-8 [8075641] Am J Psychiatry. 1995 Aug;152(8):1219-21 [7625477] Alcohol Clin Exp Res. 1995 Aug;19(4):951-4 [7485844] Psychiatry Res. 1995 Apr 28;56(3):213-20 [7568543] Alcohol Clin Exp Res. 1996 Feb;20(1):52-5 [8651462] Br J Psychiatry. 1996 Jun;168(6):762-7 [8773821] Am J Med Genet. 1996 Sep 20;67(5):473-7 [8886164] Biol Psychiatry. 1996 Oct 15;40(8):776-84 [8894071] Alcohol Alcohol Suppl. 1994;2:29-34 [8974313] Alcohol Clin Exp Res. 1997 Jun;21(4):596-601 [9194910] Alcohol Clin Exp Res. 1997 Oct;21(7):1272-7 [9347089] Alcohol Clin Exp Res. 1998 Sep;22(6):1317-23 [9756048] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Arch Gen Psychiatry. 1998 Nov;55(11):973-9 [9819065] Br J Psychiatry. 1998 Oct;173:345-50 [9926041] Mol Psychiatry. 1999 Mar;4(2):129-44 [10208445] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] Am J Hum Genet. 1999 Sep;65(3):795-807 [10441588] Ann N Y Acad Sci. 2004 Oct;1025:34-8 [15542697] Neuron. 2005 Sep 15;47(6):873-84 [16157281] Pharmacol Ther. 2005 Oct;108(1):3-17 [16098597] Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R157-62 [16244314] Psychopharmacology (Berl). 2005 Sep;181(2):327-36 [15864555] Neurobiol Learn Mem. 2006 Jan;85(1):16-29 [16198608] Nucleic Acids Res. 2006;34(4):e27 [16478714] BMC Med Genet. 2006;7:9 [16472381] Behav Genet. 2006 Jan;36(1):112-26 [16341909] Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):354-60 [16671072] Psychol Med. 2006 Jul;36(7):955-62 [16650346] Alcohol Clin Exp Res. 2006 Jul;30(7):1101-10 [16792556] NeuroRx. 2006 Jul;3(3):295-301 [16815213] Trends Genet. 2006 Jul;22(7):350-4 [16713652] Addict Biol. 2006 Sep;11(3-4):386-96 [16961766] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):918-25 [17099884] Am J Hum Genet. 2007 Jan;80(1):126-39 [17160900] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian Monkeys. AN - 70103468; 17429408 AB - To advance understanding of the neurochemical changes in Parkinson's disease (PD), we compared D2-like dopamine receptor occupancy by dopamine in the control and lesioned putamen of four pig-tailed macaques treated unilaterally with MPTP. PET and in vitro binding techniques were used to measure binding potential (BP(*)) and density of D2-like dopamine receptors (B(max)), respectively. As would be expected in PD, relatively higher values of BP(*) and B(max) and less amphetamine-induced decrease in [(11)C]raclopride binding were observed in the lesioned compared with the contralateral putamen in each animal. The percent differences between lesioned and contralateral sides were similar whether the measurements were of [(11)C]raclopride BP(*) or B(max) values, measured in vivo and in vitro, respectively. As [(11)C]raclopride BP(*) is a measure of the density of D2-like dopamine receptors available for radioligand binding (i.e., not occupied by dopamine), these findings suggest that the fractional occupancy of receptors by endogenous dopamine in the lesioned putamen is nearly equal to that in the contralateral putamen. Therefore, the absolute number of receptors occupied by dopamine, which is a product of receptor density and fractional occupancy by dopamine, is greater in the lesioned than in the contralateral putamen. One possible explanation for the lack of differences in fractional occupancy of D2 receptors by dopamine (despite a loss in available dopamine) is a lesion-induced increase in a portion of low-affinity D2 receptors to a state of high affinity for dopamine. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Chefer, Svetlana I AU - Kimes, Alane S AU - Matochik, John A AU - Horti, Andrew G AU - Kurian, Varughese AU - Shumway, Dean AU - Domino, Edward F AU - London, Edythe D AU - Mukhin, Alexey G AD - Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 270 EP - 278 VL - 33 IS - 2 SN - 0893-133X, 0893-133X KW - Receptors, Dopamine D2 KW - 0 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Positron-Emission Tomography KW - Kinetics KW - Macaca nemestrina KW - Putamen -- metabolism KW - Disease Models, Animal KW - Putamen -- diagnostic imaging KW - Brain -- drug effects KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Parkinsonian Disorders -- diagnostic imaging KW - Brain -- diagnostic imaging KW - Parkinsonian Disorders -- metabolism KW - Receptors, Dopamine D2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70103468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Estimation+of+D2-like+receptor+occupancy+by+dopamine+in+the+putamen+of+hemiparkinsonian+Monkeys.&rft.au=Chefer%2C+Svetlana+I%3BKimes%2C+Alane+S%3BMatochik%2C+John+A%3BHorti%2C+Andrew+G%3BKurian%2C+Varughese%3BShumway%2C+Dean%3BDomino%2C+Edward+F%3BLondon%2C+Edythe+D%3BMukhin%2C+Alexey+G&rft.aulast=Chefer&rft.aufirst=Svetlana&rft.date=2008-01-01&rft.volume=33&rft.issue=2&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-06 N1 - Date created - 2007-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. AN - 70102877; 17429405 AB - A functional VNTR polymorphism in the promoter of the monoamine oxidase A gene (MAOA-LPR) has previously been shown to be an important predictor of antisocial behavior in men. Testosterone analogues are known to interact with the MAOA promoter in vitro to influence gene transcription as well as in vivo to influence CSF levels of the MAO metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in human males. We examined the possible joint effects of testosterone (measured in CSF) and MAOA-LPR genotype on antisocial personality disorder and scores on the Brown-Goodwin Aggression scale in 95 unrelated male criminal alcoholics and 45 controls. The results confirm that MAOA genotype and CSF testosterone interact to predict antisocial behaviors. The MAOA/testosterone interaction also predicted low levels of CSF MHPG, which tentatively suggests the possibility that the interaction may be mediated by a direct effect on gene transcription. If replicated these findings offer plausible explanations for previous inconsistencies in studies of the relationship between testosterone and male human aggression, as well as for how MAOA genotype may influence aggressive behavior in human males. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Sjöberg, Rickard L AU - Ducci, Francesca AU - Barr, Christina S AU - Newman, Timothy K AU - Dell'osso, Liliana AU - Virkkunen, Matti AU - Goldman, David AD - Uppsala University Centre for Clinical Research, Central Hospital, Västerås, Sweden. sjobergr@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 425 EP - 430 VL - 33 IS - 2 SN - 0893-133X, 0893-133X KW - Testosterone KW - 3XMK78S47O KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Index Medicus KW - Genotype KW - Regression Analysis KW - Reference Values KW - Methoxyhydroxyphenylglycol -- cerebrospinal fluid KW - Humans KW - Alcoholism -- genetics KW - Male KW - Alcoholism -- blood KW - Antisocial Personality Disorder -- cerebrospinal fluid KW - Testosterone -- cerebrospinal fluid KW - Antisocial Personality Disorder -- genetics KW - Minisatellite Repeats -- genetics KW - Monoamine Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70102877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=A+non-additive+interaction+of+a+functional+MAO-A+VNTR+and+testosterone+predicts+antisocial+behavior.&rft.au=Sj%C3%B6berg%2C+Rickard+L%3BDucci%2C+Francesca%3BBarr%2C+Christina+S%3BNewman%2C+Timothy+K%3BDell%27osso%2C+Liliana%3BVirkkunen%2C+Matti%3BGoldman%2C+David&rft.aulast=Sj%C3%B6berg&rft.aufirst=Rickard&rft.date=2008-01-01&rft.volume=33&rft.issue=2&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-06 N1 - Date created - 2007-12-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2000 Dec 15;14(24):3075-86 [11124800] Arch Gen Psychiatry. 2001 Feb;58(2):172-7 [11177119] Psychol Med. 2002 Apr;32(3):417-27 [11989987] Psychol Bull. 2002 May;128(3):490-529 [12002699] Science. 2002 Aug 2;297(5582):851-4 [12161658] Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10789-94 [12145327] J Child Psychol Psychiatry. 2003 Nov;44(8):1092-115 [14626453] Neurotoxicology. 2004 Jan;25(1-2):21-30 [14697877] Arch Gen Psychiatry. 2004 Jul;61(7):738-44 [15237086] Psychiatry Res. 1979 Oct;1(2):131-9 [95232] Am J Psychiatry. 2006 Jun;163(6):1019-25 [16741202] J Biol Chem. 2006 Jul 28;281(30):21512-25 [16728402] Biochem Biophys Res Commun. 2006 Sep 22;348(2):763-7 [16890910] Mol Psychiatry. 2006 Sep;11(9):858-66 [16770335] Mol Psychiatry. 2006 Oct;11(10):903-13 [16801953] Biol Psychiatry. 2006 Oct 1;60(7):684-9 [16814261] Biol Psychiatry. 2007 Feb 1;61(3):405-11 [16950214] Life Sci. 1985 Oct 7;37(14):1279-86 [2413327] Int J Neurosci. 1988 Aug;41(3-4):261-4 [2460415] Br J Psychol. 1991 Feb;82 ( Pt 1):1-28 [2029601] Science. 1993 Oct 22;262(5133):578-80 [8211186] Arch Gen Psychiatry. 1994 Jan;51(1):20-7 [7506515] Neurosci Biobehav Rev. 1993 Winter;17(4):405-25 [8309650] Hum Genet. 1998 Sep;103(3):273-9 [9799080] Hum Mol Genet. 1999 Apr;8(4):621-4 [10072430] Biol Psychiatry. 1999 Sep 15;46(6):821-6 [10494451] Nature. 2005 Mar 17;434(7031):400-4 [15772666] Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5;144B(2):159-64 [17034017] Biol Psychiatry. 2007 Aug 15;62(4):355-8 [17141746] Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):59-64 [15806601] Biol Psychiatry. 2006 Jan 15;59(2):121-7 [16125147] Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6269-74 [16569698] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction. AN - 70102413; 17897630 AB - The discovery and development of medications to treat addiction and notably, cocaine addiction, have been frustrated by both the complexity of the disorder and the lack of target validation in human subjects. The dopamine transporter has historically been a primary target for cocaine abuse medication development, but addictive liability and other confounds of such inhibitors of dopamine uptake have limited clinical evaluation and validation. Herein we describe efforts to develop analogues of the dopamine uptake inhibitors GBR 12909 and benztropine that show promising profiles in animal models of cocaine abuse that contrast to that of cocaine. Their unique pharmacological profiles have provided important insights into the reinforcing actions of cocaine and we propose that clinical investigation of novel dopamine uptake inhibitors will facilitate the discovery of cocaine-abuse medications. JF - Biochemical pharmacology AU - Rothman, Richard B AU - Baumann, Michael H AU - Prisinzano, Thomas E AU - Newman, Amy Hauck AD - Clinical Psychopharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, 333 Cassell Dr., Baltimore, MD 21224, USA. Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 2 EP - 16 VL - 75 IS - 1 SN - 0006-2952, 0006-2952 KW - Dopamine Uptake Inhibitors KW - 0 KW - Piperazines KW - Benztropine KW - 1NHL2J4X8K KW - vanoxerine KW - 90X28IKH43 KW - Index Medicus KW - Behavior, Animal -- drug effects KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Disease Models, Animal KW - Structure-Activity Relationship KW - Conditioning (Psychology) -- drug effects KW - Piperazines -- therapeutic use KW - Cocaine-Related Disorders -- drug therapy KW - Benztropine -- analogs & derivatives KW - Benztropine -- therapeutic use KW - Benztropine -- pharmacology KW - Piperazines -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70102413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Dopamine+transport+inhibitors+based+on+GBR12909+and+benztropine+as+potential+medications+to+treat+cocaine+addiction.&rft.au=Rothman%2C+Richard+B%3BBaumann%2C+Michael+H%3BPrisinzano%2C+Thomas+E%3BNewman%2C+Amy+Hauck&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2008-01-01&rft.volume=75&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-26 N1 - Date created - 2007-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Drug Discov. 2002 Sep;1(9):710-26 [12209151] Nat Rev Drug Discov. 2002 Sep;1(9):731-6 [12209153] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] Bioorg Med Chem Lett. 2003 Feb 10;13(3):553-6 [12565970] J Pharmacol Exp Ther. 1994 Sep;270(3):1041-8 [7932151] J Pharmacol Exp Ther. 1994 Dec;271(3):1216-22 [7996429] Psychopharmacology (Berl). 1993;111(2):202-6 [7870953] Pharmacol Biochem Behav. 1995 Aug;51(4):687-92 [7675844] J Med Chem. 1995 Sep 29;38(20):3933-40 [7562926] Mol Neurobiol. 1995 Aug-Dec;11(1-3):1-19 [8561954] Neuropsychopharmacology. 1996 Jun;14(6):375-424 [8726752] Psychopharmacology (Berl). 1996 Jan;123(1):34-41 [8741952] J Neurosci. 1996 Dec 1;16(23):7416-27 [8922397] J Med Chem. 1996 Nov 22;39(24):4689-91 [8941381] J Med Chem. 1997 Mar 14;40(6):851-7 [9083473] Nature. 1997 Apr 24;386(6627):827-30 [9126740] Pharmacol Biochem Behav. 1997 Jul;57(3):505-12 [9218275] Naunyn Schmiedebergs Arch Pharmacol. 1997 Nov;356(5):562-9 [9402035] J Med Chem. 1997 Dec 19;40(26):4329-39 [9435902] Curr Med Chem. 1998 Aug;5(4):305-19 [9668197] Synapse. 1998 Sep;30(1):49-55 [9704880] Biol Psychiatry. 1998 Oct 1;44(7):578-91 [9787882] Am J Psychiatry. 1999 Jan;156(1):11-8 [9892292] J Pharmacol Exp Ther. 1999 Jan;288(1):302-15 [9862785] J Pharmacol Exp Ther. 2002 Jun;301(3):1190-7 [12023554] Psychopharmacology (Berl). 2002 Jun;161(4):442-8 [12073173] Ann N Y Acad Sci. 2002 Jun;965:92-108 [12105088] J Med Chem. 2003 May 8;46(10):1775-94 [12723940] J Med Chem. 2003 Jul 3;46(14):2908-16 [12825932] J Pharmacol Exp Ther. 2003 Nov;307(2):801-8 [12966155] Jpn J Pharmacol. 1991 Apr;55(4):501-11 [1832199] Trends Neurosci. 1991 Jul;14(7):299-302 [1719677] Pharmacol Biochem Behav. 1991 Oct;40(2):387-97 [1839568] Pharmacol Biochem Behav. 1992 Dec;43(4):1135-42 [1475296] Drug Alcohol Depend. 1993 Jun;33(1):31-9 [8370338] J Med Chem. 1994 Jul 22;37(15):2258-61 [8057273] Bioorg Med Chem. 2006 Jun 1;14(11):3625-34 [16460947] J Med Chem. 2006 Oct 19;49(21):6391-9 [17034144] Trends Pharmacol Sci. 2006 Dec;27(12):612-8 [17056126] Vascul Pharmacol. 2006 Oct;45(4):243-50 [16899413] J Pharmacol Exp Ther. 2007 Apr;321(1):334-44 [17255465] Synapse. 1999 Apr;32(1):44-50 [10188637] Behav Brain Res. 1999 Mar;99(2):201-8 [10512586] Nat Rev Neurosci. 2004 Dec;5(12):963-70 [15550951] J Neurosci. 2005 Feb 23;25(8):1889-93 [15728828] J Pharmacol Exp Ther. 2005 May;313(2):613-20 [15681658] J Pharmacol Exp Ther. 2005 Jun;313(3):1223-30 [15743929] J Med Chem. 2005 Jun 2;48(11):3663-79 [15916415] Am J Psychiatry. 2005 Aug;162(8):1432-40 [16055764] J Pharmacol Exp Ther. 2005 Oct;315(1):397-404 [16014753] J Pharmacol Exp Ther. 2005 Nov;315(2):631-40 [16055673] Nat Neurosci. 2005 Nov;8(11):1429-30 [16251981] J Pharmacol Exp Ther. 2000 Feb;292(2):521-9 [10640288] Psychopharmacology (Berl). 2000 Jan;147(4):426-35 [10672637] J Med Chem. 2000 Mar 23;43(6):1085-93 [10737741] Psychopharmacology (Berl). 2000 Feb;148(3):299-306 [10755743] Synapse. 2001 Jan;39(1):32-41 [11071707] Exp Clin Psychopharmacol. 2000 Nov;8(4):539-48 [11127425] J Med Chem. 2001 Feb 15;44(4):633-40 [11170654] Curr Opin Investig Drugs. 2000 Oct;1(2):241-51 [11249581] Nat Rev Neurosci. 2001 Feb;2(2):119-28 [11252991] Psychopharmacology (Berl). 2001 Apr;154(4):375-82 [11349390] J Pharmacol Exp Ther. 2001 Jul;298(1):1-6 [11408518] J Biomol Screen. 2001 Oct;6(5):325-31 [11689132] Synapse. 2002 Jan;43(1):78-85 [11746736] J Med Chem. 2002 Mar 14;45(6):1321-9 [11882001] Bioorg Med Chem Lett. 2002 May 6;12(9):1249-52 [11965364] Nat Rev Drug Discov. 2004 Apr;3(4):353-9 [15060530] J Pharmacol Exp Ther. 2004 May;309(2):650-60 [14755006] J Med Chem. 2004 Jun 17;47(13):3388-98 [15189035] Mol Pharmacol. 1971 Jan;7(1):66-80 [5552252] J Recept Res. 1981;2(3):233-43 [7334483] J Clin Psychopharmacol. 1986 Feb;6(1 Suppl):24S-29S [2870089] J Neurochem. 1987 Jun;48(6):1887-96 [2952763] Eur J Pharmacol. 1987 Mar 17;135(2):123-8 [3582491] J Pharmacol Exp Ther. 1989 Oct;251(1):150-5 [2529365] Eur J Pharmacol. 1989 Aug 3;166(3):493-504 [2530094] Eur J Pharmacol. 1989 Aug 29;167(3):385-95 [2530095] FEBS Lett. 1989 Nov 6;257(2):341-4 [2583282] Life Sci. 1990;46(20):PL17-21 [2111866] J Pharmacol Exp Ther. 1990 Jul;254(1):312-7 [2195158] Int Clin Psychopharmacol. 1990 Oct;5(4):237-51 [2150527] J Pharmacol Exp Ther. 1991 Jul 1;258(1):178-85 [1677037] J Pharmacol Exp Ther. 1991 Aug;258(2):626-32 [1678014] Psychopharmacology (Berl). 1991;104(2):177-80 [1831559] J Med Chem. 1999 Dec 2;42(24):5029-42 [10585212] Addiction. 2002 Aug;97(8):931-49 [12144591] Med Res Rev. 2002 Sep;22(5):429-64 [12210554] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rous sarcoma virus (RSV) integration in vivo: a CA dinucleotide is not required in U3, and RSV linear DNA does not autointegrate. AN - 70101013; 17959663 AB - The sequences required for integration of retroviral DNA have been analyzed in vitro. However, the in vitro experiments do not agree on which sequences are required for integration: for example, whether or not the conserved CA dinucleotide in the 3' end of the viral DNA is required for normal integration. At least a portion of the problem is due to differences in the experimental conditions used in the in vitro assays. To avoid the issue of what experimental conditions to use, we took an in vivo approach. We made mutations in the 5' end of the U3 sequence of the Rous sarcoma virus (RSV)-derived vector RSVP(A)Z. We present evidence that, in RSV, the CA dinucleotide in the 5' end of U3 is not essential for appropriate integration. This result differs from the results seen with mutations in the U5 end, where the CA appears to be essential for proper integration in vivo. In addition, based on the structure of circular viral DNAs smaller than the full-length viral genome, our results suggest that there is little, if any, integrase-mediated autointegration of RSV linear DNA in vivo. JF - Journal of virology AU - Oh, Jangsuk AU - Chang, Kevin W AU - Wierzchoslawski, Rafal AU - Alvord, W Gregory AU - Hughes, Stephen H AD - HIV Drug Resistance Program, NCI at Frederick, P.O. Box B, Bldg. 539, Rm. 130A, Frederick, MD 21702-1201, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 503 EP - 512 VL - 82 IS - 1 KW - DNA, Viral KW - 0 KW - RNA, Viral KW - Integrases KW - EC 2.7.7.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Conserved Sequence KW - Integrases -- physiology KW - DNA, Viral -- genetics KW - DNA, Viral -- metabolism KW - Rous sarcoma virus -- genetics KW - RNA, Viral -- genetics KW - Virus Integration KW - Rous sarcoma virus -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70101013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Rous+sarcoma+virus+%28RSV%29+integration+in+vivo%3A+a+CA+dinucleotide+is+not+required+in+U3%2C+and+RSV+linear+DNA+does+not+autointegrate.&rft.au=Oh%2C+Jangsuk%3BChang%2C+Kevin+W%3BWierzchoslawski%2C+Rafal%3BAlvord%2C+W+Gregory%3BHughes%2C+Stephen+H&rft.aulast=Oh&rft.aufirst=Jangsuk&rft.date=2008-01-01&rft.volume=82&rft.issue=1&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2005 Nov;79(21):13694-704 [16227289] EMBO J. 1998 Oct 1;17(19):5832-43 [9755183] J Virol. 2006 Oct;80(20):10281-4 [17005708] J Virol. 2001 Feb;75(3):1359-70 [11152509] J Virol. 2002 Feb;76(4):1762-8 [11799171] Proc Natl Acad Sci U S A. 1980 Jul;77(7):3937-41 [6254003] Cell. 1980 Nov;22(2 Pt 2):379-86 [6256079] Proc Natl Acad Sci U S A. 1981 Jul;78(7):4299-303 [6270669] Nature. 1983 Nov 10-16;306(5939):155-60 [6316141] Cell. 1984 Jul;37(3):1043-52 [6204767] Proc Natl Acad Sci U S A. 1984 Oct;81(20):6461-5 [6208550] Cell. 1985 Sep;42(2):573-80 [4028161] J Virol. 1986 Jan;57(1):37-45 [2416955] Proc Natl Acad Sci U S A. 1989 May;86(9):3065-9 [2524066] Cell. 1989 Jul 14;58(1):47-54 [2546673] Cell. 1990 Aug 24;62(4):829-37 [2167180] J Virol. 1990 Nov;64(11):5475-84 [2170682] J Virol. 1990 Dec;64(12):5958-65 [2173775] Mol Cell Biol. 1991 Mar;11(3):1419-30 [1847499] J Virol. 1991 Sep;65(9):4636-44 [1870194] J Virol. 1991 Oct;65(10):5624-30 [1895409] J Virol. 1992 Apr;66(4):2359-68 [1548767] J Virol. 1992 Dec;66(12):7414-9 [1433523] J Virol. 1994 Aug;68(8):4768-75 [8035478] J Virol. 1995 May;69(5):3216-9 [7707554] J Virol. 1995 Nov;69(11):6687-96 [7474078] Virology. 1998 Sep 1;248(2):295-304 [9721238] Virology. 1998 Sep 1;248(2):305-11 [9721239] J Virol. 1998 Oct;72(10):8396-402 [9733892] J Virol. 2004 Dec;78(23):13315-24 [15542682] J Virol. 1999 Nov;73(11):9011-20 [10516007] J Virol. 2006 Jan;80(1):451-9 [16352569] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Endogenous bufadienolide mediates pressor response to ethanol withdrawal in rats. AN - 70098129; 17683916 AB - An endogenous natriuretic and vasoconstrictor Na/K-ATPase inhibitor, marinobufagenin (MBG), is implicated in NaCl-induced hypertension and in ethanol addiction. In rats, MBG suppresses voluntary alcohol intake, while immunization against MBG induces alcohol-seeking behavior. Since alcohol withdrawal is associated with elevation of blood pressure (BP) and renal sodium retention, we hypothesized that MBG mediates pressor response to ethanol withdrawal. In male Sprague-Dawley rats, forced ethanol intake (20% v/v, 2.8+/-0.2 g/day for 7 days) did not affect BP and MBG excretion. Ethanol withdrawal was associated with a 21 mm Hg increase in BP, a 10% decrease in hematocrit, and a three-fold increase in renal MBG excretion. In vivo administration of anti-MBG antibody to rats prevented withdrawal-induced BP elevation. Therefore, MBG mediates pressor response to ethanol withdrawal, and may link mechanisms of ethanol dependence and hypertension. JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology AU - Kashkin, Vladimir A AU - Zvartau, Edwin E AU - Fedorova, Olga V AU - Bagrov, Yakov Y AU - Lakatta, Edward G AU - Bagrov, Alexei Y AD - Laboratory of Cardiovascular Science, National Institute on Aging/NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 74 EP - 77 VL - 18 IS - 1 SN - 0924-977X, 0924-977X KW - Bufanolides KW - 0 KW - Central Nervous System Depressants KW - Vasoconstrictor Agents KW - Ethanol KW - 3K9958V90M KW - marinobufagenin KW - 470-42-8 KW - Ouabain KW - 5ACL011P69 KW - Sodium KW - 9NEZ333N27 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Ouabain -- urine KW - Hematocrit KW - Sodium -- urine KW - Male KW - Bufanolides -- therapeutic use KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance Withdrawal Syndrome -- drug therapy KW - Vasoconstrictor Agents -- urine KW - Blood Pressure -- drug effects KW - Vasoconstrictor Agents -- therapeutic use KW - Bufanolides -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70098129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.atitle=Endogenous+bufadienolide+mediates+pressor+response+to+ethanol+withdrawal+in+rats.&rft.au=Kashkin%2C+Vladimir+A%3BZvartau%2C+Edwin+E%3BFedorova%2C+Olga+V%3BBagrov%2C+Yakov+Y%3BLakatta%2C+Edward+G%3BBagrov%2C+Alexei+Y&rft.aulast=Kashkin&rft.aufirst=Vladimir&rft.date=2008-01-01&rft.volume=18&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.issn=0924977X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Pharmacol. 1996 Jun 3;305(1-3):39-44 [8813529] Hypertension. 1996 Mar;27(3 Pt 2):481-90 [8613190] Life Sci. 1999;64(20):PL219-25 [10350362] J Affect Disord. 1999 Aug;54(3):261-7 [10467969] J Hypertens. 2005 Aug;23(8):1515-23 [16003178] Neurobiol Learn Mem. 2005 Sep;84(2):102-10 [15961330] Biol Psychiatry. 2006 Sep 1;60(5):491-9 [16712803] Eur Neuropsychopharmacol. 2002 Feb;12(1):1-12 [11788235] Eur Psychiatry. 2000 Dec;15(8):483-8 [11175926] Life Sci. 2006 Sep 20;79(17):1585-92 [16828490] Circulation. 2002 Mar 5;105(9):1122-7 [11877366] Eur Neuropsychopharmacol. 2002 Jun;12(3):217-23 [12007673] Alcohol Clin Exp Res. 2002 Dec;26(12):1810-5 [12500104] Hypertension. 1986 Jun;8(6 Pt 2):II127-34 [3522418] Biol Psychiatry. 1998 Jul 1;44(1):47-51 [9646882] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists. AN - 70094087; 17764108 AB - High-dose ionizing radiation exposure to the breast and rare autosomal dominant genes have been linked with increased breast cancer risk, but the role of low-to-moderate doses from protracted radiation exposure in breast cancer risk and its potential modification by polymorphisms in DNA repair genes has not been previously investigated among large numbers of radiation-exposed women with detailed exposure data. Using carefully reconstructed estimates of cumulative breast doses from occupational and personal diagnostic ionizing radiation, we investigated the potential modification of radiation-related breast cancer risk by 55 candidate single nucleotide polymorphisms in 17 genes involved in base excision or DNA double-strand break repair among 859 cases and 1083 controls from the United States Radiologic Technologists (USRT) cohort. In multivariable analyses, WRN V114I (rs2230009) significantly modified the association between cumulative occupational breast dose and risk of breast cancer (adjusted for personal diagnostic exposure) (p = 0.04) and BRCA1 D652N (rs4986850), PRKDC IVS15 + 6C > T (rs1231202), PRKDC IVS34 + 39T > C (rs8178097) and PRKDC IVS31 - 634C > A (rs10109984) significantly altered the personal diagnostic radiation exposure-response relationship (adjusted for occupational dose) (p < or = 0.05). None of the remaining 50 SNPs significantly modified breast cancer radiation dose-response relationships. The USRT genetic study provided a unique opportunity to examine the joint effects of common genetic variation and ionizing radiation exposure on breast cancer risk using detailed occupational and personal diagnostic exposure data. The suggestive evidence found for modification of radiation-related breast cancer risk for 5 of the 55 SNPs evaluated requires confirmation in larger studies of women with quantified radiation breast doses in the low-to-moderate range. Copyright 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Bhatti, Parveen AU - Struewing, Jeffery P AU - Alexander, Bruce H AU - Hauptmann, Michael AU - Bowen, Laura AU - Mateus-Pereira, Lutecia H AU - Pineda, Marbin A AU - Simon, Steven L AU - Weinstock, Robert M AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Preston, Dale L AU - Linet, Martha S AU - Doody, Michele M AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. bhattip@mail.nih.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 177 EP - 182 VL - 122 IS - 1 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Genotype KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Retrospective Studies KW - Incidence KW - Aged KW - Middle Aged KW - Dose-Response Relationship, Radiation KW - United States -- epidemiology KW - Female KW - Radiation, Ionizing KW - Occupational Exposure KW - DNA Repair -- genetics KW - Neoplasms, Radiation-Induced -- etiology KW - DNA Repair Enzymes -- genetics KW - Neoplasms, Radiation-Induced -- epidemiology KW - Breast Neoplasms -- etiology KW - Technology, Radiologic -- manpower KW - Breast Neoplasms -- epidemiology KW - Polymorphism, Single Nucleotide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70094087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Polymorphisms+in+DNA+repair+genes%2C+ionizing+radiation+exposure+and+risk+of+breast+cancer+in+U.S.+Radiologic+technologists.&rft.au=Bhatti%2C+Parveen%3BStruewing%2C+Jeffery+P%3BAlexander%2C+Bruce+H%3BHauptmann%2C+Michael%3BBowen%2C+Laura%3BMateus-Pereira%2C+Lutecia+H%3BPineda%2C+Marbin+A%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BPreston%2C+Dale+L%3BLinet%2C+Martha+S%3BDoody%2C+Michele+M%3BSigurdson%2C+Alice+J&rft.aulast=Bhatti&rft.aufirst=Parveen&rft.date=2008-01-01&rft.volume=122&rft.issue=1&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incorporation of a polypeptide segment into the beta-domain pore during the assembly of a bacterial autotransporter. AN - 70092698; 18047580 AB - Bacterial autotransporters consist of an N-terminal 'passenger domain' that is transported into the extracellular space by an unknown mechanism and a C-terminal 'beta-domain' that forms a beta-barrel in the outer membrane. Recent studies have revealed that fully assembled autotransporters have an unusual architecture in which a small passenger domain segment traverses the pore formed by the beta-domain. It is unclear, however, whether this configuration forms prior to passenger domain translocation or results from the translocation of the passenger domain through the beta-domain pore. By examining the accessibility of tobacco etch virus protease sites and single-cysteine residues in the passenger domain of the Escherichia coli O157:H7 autotransporter EspP at different stages of protein biogenesis, we identified a novel pre-translocation intermediate whose topology resembles that of the fully assembled protein. This intermediate was isolated in the periplasm in cell fractionation experiments. The data strongly suggest that the EspP beta-domain and an embedded polypeptide segment are integrated into the outer membrane as a single pre-formed unit. The data also provide indirect evidence that at least some outer membrane proteins acquire considerable tertiary structure prior to their membrane integration. JF - Molecular microbiology AU - Ieva, Raffaele AU - Skillman, Kristen M AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0538, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 188 EP - 201 VL - 67 IS - 1 SN - 0950-382X, 0950-382X KW - Bacterial Outer Membrane Proteins KW - 0 KW - Escherichia coli Proteins KW - Peptides KW - Porins KW - EspP protein, E coli KW - EC 3.4.21.- KW - Serine Endopeptidases KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Porins -- genetics KW - Amino Acid Motifs KW - Porins -- chemistry KW - Periplasm -- metabolism KW - Protein Structure, Tertiary KW - Plasmids KW - Protein Transport KW - Escherichia coli Proteins -- chemistry KW - Escherichia coli O157 -- chemistry KW - Serine Endopeptidases -- genetics KW - Bacterial Outer Membrane Proteins -- genetics KW - Serine Endopeptidases -- chemistry KW - Protein Folding KW - Peptides -- metabolism KW - Bacterial Outer Membrane Proteins -- chemistry KW - Escherichia coli Proteins -- genetics KW - Escherichia coli O157 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70092698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Incorporation+of+a+polypeptide+segment+into+the+beta-domain+pore+during+the+assembly+of+a+bacterial+autotransporter.&rft.au=Ieva%2C+Raffaele%3BSkillman%2C+Kristen+M%3BBernstein%2C+Harris+D&rft.aulast=Ieva&rft.aufirst=Raffaele&rft.date=2008-01-01&rft.volume=67&rft.issue=1&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-28 N1 - Date created - 2007-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy. AN - 70089487; 18000394 AB - The development of cancer drugs is slow and costly. One approach to accelerate the availability of new drugs is to reposition drugs approved for other indications as anti-cancer agents. HIV protease inhibitors (HIV PIs) are useful in treating HIV infection and cause toxicities in humans that are similar to those observed when the kinase Akt, a target for cancer therapy, is inhibited. To test whether HIV PIs inhibited Akt and cancer cell proliferation, we screened 6 HIV PIs and found that three, ritonavir, saquinavir and nelfinavir, inhibit the growth of over 60 cancer cell lines derived from 9 different tumor types; Nelfinavir is the most potent. Nelfinavir causes caspase-dependent apoptosis and non-apoptotic death, as well as endoplasmic reticulum (ER) stress and autophagy. Nelfinavir blocks growth factor receptor activation and decreases growth factor-induced and endogenous Akt signaling. In vivo, nelfinavir inhibits tumor growth and upregulates markers of ER stress, autophagy and apoptosis. Nelfinavir is currently being tested in cancer patients in Phase I clinical trials where biomarkers will be assessed. Current studies are focused on measuring autophagy in clinical specimens and identifying combination strategies that will exploit the induction of autophagy and increase the effectiveness of nelfinavir. JF - Autophagy AU - Gills, Joell J AU - Lopiccolo, Jaclyn AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 107 EP - 109 VL - 4 IS - 1 KW - Antineoplastic Agents KW - 0 KW - HIV Protease Inhibitors KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - EEF2K protein, human KW - EC 2.7.1.17 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Elongation Factor 2 Kinase KW - EC 2.7.11.20 KW - Nelfinavir KW - HO3OGH5D7I KW - Index Medicus KW - Signal Transduction -- physiology KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Elongation Factor 2 Kinase -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Humans KW - Cell Line, Tumor KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Autophagy -- drug effects KW - Nelfinavir -- pharmacology KW - HIV Protease Inhibitors -- pharmacology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70089487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autophagy&rft.atitle=Nelfinavir%2C+a+new+anti-cancer+drug+with+pleiotropic+effects+and+many+paths+to+autophagy.&rft.au=Gills%2C+Joell+J%3BLopiccolo%2C+Jaclyn%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2008-01-01&rft.volume=4&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Autophagy&rft.issn=1554-8635&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-09 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Presynaptic modulation by endocannabinoids. AN - 70085695; 18064422 AB - Modulation of neurotransmitter release by G-protein-coupled receptors (GPCRs) is a prominent presynaptic mechanism for regulation of synaptic transmission. Activation of GPCRs located at the presynaptic terminal can decrease the probability of neurotransmitter release. This presynaptic depression involves activation of Gi/o-type G-proteins that mediate different inhibitory mechanisms, including inhibition of voltage-gated calcium channels, activation of potassium channels, and direct inhibition of the vesicle fusion process. A variety of neurotransmitters and modulatory agents can activate GPCRs that produce presynaptic depression. Among these are lipid metabolites that serve as agonists for GPCRs. The discovery of endocannabinoids and their cognate receptors, including the CB1 receptor, has stimulated intense investigation into the neurophysiological roles of these lipid metabolites. It is now clear that presynaptic depression is the major physiological role for the CB1 receptor. Endocannabinoids activate this receptor mainly via a retrograde signaling process in which these compounds are synthesized in and released from postsynaptic neuronal elements, and travel back to the presynaptic terminal to act on the CB1 receptor. This retrograde endocannabinoid modulation has been implicated in short-term synaptic depression, including suppression of excitatory or inhibitory transmission induced by postsynaptic depolarization and transient synaptic depression induced by activation of postsynaptic GPCRs during agonist treatment or synaptic activation. Endocannabinoids and the CB1 receptor also play a key role in one form of long-term synaptic depression (LTD) that involves a longlasting decrease in neurotransmitter release. JF - Handbook of experimental pharmacology AU - Lovinger, David M AD - Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892-9411, USA. lovindav@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 435 EP - 477 IS - 184 SN - 0171-2004, 0171-2004 KW - Cannabinoid Receptor Modulators KW - 0 KW - Cannabinoids KW - Endocannabinoids KW - Neurotransmitter Uptake Inhibitors KW - Receptor, Cannabinoid, CB1 KW - Receptors, Cannabinoid KW - Receptors, Presynaptic KW - Index Medicus KW - Behavior -- drug effects KW - Animals KW - Long-Term Potentiation -- physiology KW - Receptor, Cannabinoid, CB1 -- physiology KW - Cannabinoids -- toxicity KW - Cannabinoids -- metabolism KW - Receptor, Cannabinoid, CB1 -- drug effects KW - Neurotransmitter Uptake Inhibitors -- pharmacology KW - Long-Term Potentiation -- drug effects KW - Humans KW - Signal Transduction -- drug effects KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Neuronal Plasticity -- drug effects KW - Cannabinoids -- pharmacology KW - Receptors, Cannabinoid -- metabolism KW - Cannabinoid Receptor Modulators -- physiology KW - Receptors, Cannabinoid -- physiology KW - Cannabinoid Receptor Modulators -- metabolism KW - Receptors, Presynaptic -- physiology KW - Receptors, Cannabinoid -- drug effects KW - Receptors, Presynaptic -- metabolism KW - Receptors, Presynaptic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70085695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Presynaptic+modulation+by+endocannabinoids.&rft.au=Lovinger%2C+David+M&rft.aulast=Lovinger&rft.aufirst=David&rft.date=2008-01-01&rft.volume=&rft.issue=184&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-20 N1 - Date created - 2007-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk factors for childhood leukaemia. Discussion and summary. AN - 69935968; 19066250 JF - Radiation protection dosimetry AU - Portier, Christopher AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. portier@niehs.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 273 EP - 274 VL - 132 IS - 2 SN - 0144-8420, 0144-8420 KW - Index Medicus KW - Infant KW - Risk Factors KW - Humans KW - Infant, Newborn KW - Incidence KW - Child KW - Child, Preschool KW - Leukemia -- epidemiology KW - Environmental Exposure -- analysis KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69935968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=Risk+factors+for+childhood+leukaemia.+Discussion+and+summary.&rft.au=Portier%2C+Christopher&rft.aulast=Portier&rft.aufirst=Christopher&rft.date=2008-01-01&rft.volume=132&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncn282 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-01 N1 - Date created - 2009-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: IARC Monogr Eval Carcinog Risks Hum. 2002;80:1-395 [12071196] J Natl Cancer Inst Monogr. 2008;(39):87-90 [18648011] Cancer. 2008 Jan 15;112(2):416-32 [18074355] Lancet. 2005 Jun 18-24;365(9477):2088 [15964441] Environ Health Perspect. 2007 Jan;115(1):146-50 [17366835] Pediatr Clin North Am. 2007 Feb;54(1):177-203, x [17306690] Nat Rev Cancer. 2006 Mar;6(3):193-203 [16467884] Crit Rev Clin Lab Sci. 2007;44(3):203-42 [17453918] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/rpd/ncn282 ER - TY - JOUR T1 - Detecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanoma. AN - 69919546; 19099253 AB - Signaling networks play crucial roles in the changes leading to malignancy. In melanoma, increased Wnt5A expression increases melanoma cell motility via activation of protein kinase C (PKC). PKC isoforms comprise a family ofserine/threonine kinases that are involved in the transduction of signals for cell proliferation, differentiation, and metastasis. The important role of PKC in processes leading to carcinogenesis and tumor cell invasion would render PKC a suitable target for cancer therapy, if not for its ubiquitous nature. Thus, targeting pathways leading to PKC activation that are more tumor specific, such as the non-canonical Wnt pathway, may prove to be the key to targeting PKC in cancer. Here we summarize the current understanding of the Wnt/calcium pathway and discuss methods of detecting activated/phosphorylated PKC as a result of Wnt signaling in malignant melanoma. We have shown that overexpression of Wnt5A results in the activation of PKC, while inhibition of Wnt5A via small interfering RNA (siRNA) treatment results in its inactivation. In addition, the use of PKC activators and inhibitors has allowed us to study Wnt5A effects on downstream genes that may prove to be key targets for molecular therapy. JF - Methods in molecular biology (Clifton, N.J.) AU - Dissanayake, Samudra K AU - Weeraratna, Ashani T AD - Laboratory of Immunology, National Institutes of Health, National Institute of Aging, Gerontology Research Center, Baltimore, MD, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 157 EP - 172 VL - 468 SN - 1064-3745, 1064-3745 KW - Isoenzymes KW - 0 KW - RNA, Small Interfering KW - Recombinant Fusion Proteins KW - Wnt Proteins KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Phosphorylation KW - Humans KW - Recombinant Fusion Proteins -- genetics KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - Blotting, Western -- methods KW - RNA, Small Interfering -- metabolism KW - Wnt Proteins -- metabolism KW - Protein Kinase C -- metabolism KW - Calcium -- metabolism KW - Wnt Proteins -- genetics KW - Signal Transduction -- physiology KW - Protein Kinase C -- genetics KW - Skin Neoplasms -- metabolism KW - Melanoma -- metabolism KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69919546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Detecting+PKC+phosphorylation+as+part+of+the+Wnt%2Fcalcium+pathway+in+cutaneous+melanoma.&rft.au=Dissanayake%2C+Samudra+K%3BWeeraratna%2C+Ashani+T&rft.aulast=Dissanayake&rft.aufirst=Samudra&rft.date=2008-01-01&rft.volume=468&rft.issue=&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-249-6_12 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-12-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Cell. 2002 Apr;1(3):279-88 [12086864] Nature. 2000 Aug 3;406(6795):536-40 [10952317] Oncogene. 2000 Jun 29;19(28):3213-5 [10918576] Trends Genet. 2000 Jul;16(7):279-83 [10858654] J Biol Chem. 2007 Jun 8;282(23):17259-71 [17426020] Oncogene. 2007 May 31;26(26):3846-56 [17160014] Melanoma Res. 2004 Apr;14(2):85-9 [15057036] Cancer Metastasis Rev. 2005 Jun;24(2):287-300 [15986138] Curr Biol. 1999 Jul 1;9(13):695-8 [10395542] Curr Biol. 1995 Dec 1;5(12):1394-1403 [8749392] Exp Dermatol. 1993 Feb;2(1):17-24 [8156166] Melanoma Res. 1992 Dec;2(5-6):337-43 [1337998] Int J Oncol. 2005 Nov;27(5):1329-39 [16211229] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-249-6_12 ER - TY - JOUR T1 - Treatment of acute lymphoblastic leukemia in children and adolescents: peaks and pitfalls. AN - 69895675; 19074113 AB - Survival of children with acute lymphoblastic leukemia (ALL) is often described as the success story for oncology. The improvements in the treatment of ALL represent the work of cooperative groups at their best. Fifty years ago a pediatric oncologist would have never considered using the term "cure" in a discussion with a family whose child was diagnosed with ALL. Today the term is not only used in the initial discussion but referred to frequently thereafter. However, as we all know, cure is not assured and is not obtained without sequelae. This review will focus on the improvements in treatment for newly diagnosed ALL in children and adolescents according to risk group and some of the challenges that remain despite the improved outcome. JF - Hematology. American Society of Hematology. Education Program AU - Seibel, Nita L AD - Clinical Investigations Branch, Cancer Treatment Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. seibelnl@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 374 EP - 380 SN - 1520-4391, 1520-4391 KW - Antimetabolites, Antineoplastic KW - 0 KW - 6-Mercaptopurine KW - E7WED276I5 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Young Adult KW - Disease-Free Survival KW - 6-Mercaptopurine -- therapeutic use KW - Humans KW - Retrospective Studies KW - Child KW - Risk Assessment KW - Survival Rate KW - Treatment Outcome KW - Methotrexate -- therapeutic use KW - Adolescent KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Diploidy KW - Remission Induction KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- mortality KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69895675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hematology.+American+Society+of+Hematology.+Education+Program&rft.atitle=Treatment+of+acute+lymphoblastic+leukemia+in+children+and+adolescents%3A+peaks+and+pitfalls.&rft.au=Seibel%2C+Nita+L&rft.aulast=Seibel&rft.aufirst=Nita&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Hematology.+American+Society+of+Hematology.+Education+Program&rft.issn=15204391&rft_id=info:doi/10.1182%2Fasheducation-2008.1.374 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/asheducation-2008.1.374 ER - TY - JOUR T1 - Marijuana neurobiology and treatment. AN - 69849778; 19042204 AB - Marijuana is the number one illicit drug of abuse worldwide and a major public health problem, especially in the younger population. The objective of this article is to update and review the state of the science and treatments available for marijuana dependence based on a pre-meeting workshop that was presented at ISAM 2006. At the workshop, several papers were presented addressing the neurobiology and pharmacology of marijuana and treatment approaches, both psychotherapy and medications, for marijuana withdrawal. Medicolegal and ethical issues concerning marijuana medical use were also discussed. Concise summaries of these presentations are incorporated in this article, which is meant to be an updated review of the state of the science. Major advances have been made in understanding the underpinning of marijuana dependence and the role of the CNS cannabinoid system, which is a major area for targeting medications to treat marijuana withdrawal and dependence, as well as other addictions. Behavioral therapies are efficacious for facilitating abstinence from marijuana. Nefazadone, Marinol, and buspirone are showing early positive signals for efficacy in ameliorating marijuana withdrawal symptoms. Effective psychotherapeutic approaches are available and promising medications studies need to be confirmed in outpatient trials. The next few years looking promising for translational research efforts to make treatment widely accessible to patients with marijuana dependence. JF - Substance abuse AU - Elkashef, Ahmed AU - Vocci, Frank AU - Huestis, Marilyn AU - Haney, Margaret AU - Budney, Alan AU - Gruber, Amanda AU - el-Guebaly, Nady AD - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 17 EP - 29 VL - 29 IS - 3 SN - 0889-7077, 0889-7077 KW - Narcotic Antagonists KW - 0 KW - Triazoles KW - nefazodone KW - 59H4FCV1TF KW - Dronabinol KW - 7J8897W37S KW - Buspirone KW - TK65WKS8HL KW - Index Medicus KW - Cognitive Therapy KW - Humans KW - Social Facilitation KW - Dronabinol -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Buspirone -- therapeutic use KW - Marijuana Abuse -- rehabilitation KW - Brain -- drug effects KW - Marijuana Abuse -- therapy KW - Triazoles -- therapeutic use KW - Cannabis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69849778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Marijuana+neurobiology+and+treatment.&rft.au=Elkashef%2C+Ahmed%3BVocci%2C+Frank%3BHuestis%2C+Marilyn%3BHaney%2C+Margaret%3BBudney%2C+Alan%3BGruber%2C+Amanda%3Bel-Guebaly%2C+Nady&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2008-01-01&rft.volume=29&rft.issue=3&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/10.1080%2F08897070802218166 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Consult Clin Psychol. 2004 Jun;72(3):455-66 [15279529] Am J Addict. 2004 Jan-Feb;13(1):21-32 [14766435] J Subst Abuse Treat. 2004 Oct;27(3):195-6 [15501372] J Subst Abuse Treat. 2004 Oct;27(3):197-213 [15501373] Am J Psychiatry. 2004 Nov;161(11):1967-77 [15514394] Psychopharmacology (Berl). 1981;74(3):208-12 [6267648] J Pharmacol Exp Ther. 1986 Nov;239(2):311-9 [3021952] Int J Addict. 1987 Jul;22(7):639-51 [3497886] Nature. 1990 Aug 9;346(6284):561-4 [2165569] J Anal Toxicol. 1992 Sep-Oct;16(5):302-6 [1338218] J Consult Clin Psychol. 1993 Dec;61(6):1100-4 [8113490] Arch Gen Psychiatry. 1994 Jul;51(7):568-76 [8031230] J Consult Clin Psychol. 1994 Feb;62(1):92-9 [8034835] Drug Alcohol Depend. 1995 Nov;40(1):9-15 [8746919] Psychopharmacology (Berl). 1999 Feb;141(4):395-404 [10090647] Addict Behav. 1999 Jan-Feb;24(1):111-4 [10189977] Psychopharmacology (Berl). 1999 Apr;143(3):302-8 [10353434] J Am Acad Child Adolesc Psychiatry. 2005 Jun;44(6):513-21 [15908833] Am Heart J. 2006 Mar;151(3):754.e1-754.e5 [16504646] J Consult Clin Psychol. 2006 Feb;74(1):42-54 [16551142] J Consult Clin Psychol. 2006 Apr;74(2):307-16 [16649875] Am J Addict. 2006 Sep-Oct;15(5):404 [16966201] Addict Behav. 2007 Jun;32(6):1220-36 [16996224] Neuropsychopharmacology. 2007 Jun;32(6):1391-403 [17091128] Drug Alcohol Depend. 2007 Oct 8;90(2-3):210-23 [17481828] Drug Alcohol Depend. 2005 Jul;79(1):11-22 [15943940] Curr Psychiatry Rep. 2005 Oct;7(5):360-6 [16216154] Addiction. 1999 Sep;94(9):1311-22 [10615717] Ann Emerg Med. 2000 Apr;35(4):398-9 [10736129] Nat Neurosci. 2000 Nov;3(11):1073-4 [11036260] J Consult Clin Psychol. 2000 Oct;68(5):898-908 [11068976] J Consult Clin Psychol. 2000 Dec;68(6):1051-61 [11142539] Arch Gen Psychiatry. 2001 Apr;58(4):322-8 [11296091] Psychopharmacology (Berl). 2001 May;155(2):171-9 [11401006] J Subst Abuse Treat. 2001 Sep;21(2):55-64; discussion 65-6 [11551733] Arch Gen Psychiatry. 2001 Oct;58(10):909-15 [11576028] Arch Gen Psychiatry. 2001 Oct;58(10):917-24 [11576029] Nat Med. 2001 Oct;7(10):1151-4 [11590440] J Consult Clin Psychol. 2001 Oct;69(5):802-13 [11680557] Am J Drug Alcohol Abuse. 2001 Nov;27(4):651-88 [11727882] J Neurosci. 2001 Dec 15;21(24):9867-76 [11739594] Neuropsychopharmacology. 2002 Apr;26(4):479-88 [11927172] Drug Alcohol Depend. 2002 Aug 1;67(3):301-9 [12127201] Psychopharmacology (Berl). 2002 Dec;164(4):407-15 [12457271] Psychopharmacology (Berl). 2003 Jan;165(2):157-65 [12439626] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1393-8 [12538878] J Subst Abuse Treat. 2003 Jun;24(4):369-76 [12867212] J Int Neuropsychol Soc. 2003 Jul;9(5):679-89 [12901774] J Abnorm Psychol. 2003 Aug;112(3):393-402 [12943018] J Subst Abuse Treat. 2003 Sep;25(2):85-9 [14629990] Psychol Med. 2003 Nov;33(8):1415-22 [14672250] Neuropsychopharmacology. 2004 Jan;29(1):158-70 [14560320] Prog Neuropsychopharmacol Biol Psychiatry. 2004 Aug;28(5):849-63 [15363608] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08897070802218166 ER - TY - JOUR T1 - Medical consequences of drug abuse and co-occurring infections: research at the National Institute on Drug Abuse. AN - 69846888; 19042203 AB - Substance abuse still remains one of the major problems in the world today, with millions of people abusing legal and illegal drugs. In addition, a billion people may also be infected with one or more infections. Both drugs of abuse and infections are associated with enormous burden of social, economic, and health consequences. This article briefly discusses a few medical consequences of drugs of abuse and infections such as human immunodeficiency virus, hepatitis C virus, psychiatric complications in hepatitis C infection, pharmacokinetic drug-drug interactions among medications used in the treatment of addiction and infections, and new drugs in development for the treatment of infections. Research is encouraged to study interactions between infections, drugs of abuse, and underlying pathophysiologic and molecular/genetic mechanisms of these interactions. JF - Substance abuse AU - Khalsa, Jag H AU - Treisman, Glenn AU - McCance-Katz, Elinore AU - Tedaldi, Ellen AD - National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA. jk98p@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 5 EP - 16 VL - 29 IS - 3 SN - 0889-7077, 0889-7077 KW - Anti-Retroviral Agents KW - 0 KW - Antiviral Agents KW - Index Medicus KW - United States KW - Antiviral Agents -- therapeutic use KW - Hepatitis C -- drug therapy KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - HIV Infections -- drug therapy KW - Anti-Retroviral Agents -- classification KW - Hepatitis C -- epidemiology KW - HIV Infections -- epidemiology KW - Comorbidity KW - Anti-Retroviral Agents -- therapeutic use KW - Antiviral Agents -- classification KW - Bacterial Infections -- epidemiology KW - National Institute on Drug Abuse (U.S.) KW - Health Status KW - Virus Diseases -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69846888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Medical+consequences+of+drug+abuse+and+co-occurring+infections%3A+research+at+the+National+Institute+on+Drug+Abuse.&rft.au=Khalsa%2C+Jag+H%3BTreisman%2C+Glenn%3BMcCance-Katz%2C+Elinore%3BTedaldi%2C+Ellen&rft.aulast=Khalsa&rft.aufirst=Jag&rft.date=2008-01-01&rft.volume=29&rft.issue=3&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/10.1080%2F08897070802218661 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Infect Dis. 2003 Aug 15;37(4):476-82 [12905130] Clin Infect Dis. 2003 Jul 1;37(1):33-40 [12830406] Am J Addict. 2004 Jan-Feb;13(1):1-20 [14766434] Am J Addict. 2004 Mar-Apr;13(2):163-80 [15204667] N Engl J Med. 2004 Jul 29;351(5):438-50 [15282351] N Engl J Med. 2004 Jul 29;351(5):451-9 [15282352] Semin Liver Dis. 2004 Aug;24(3):305-15 [15349807] N Engl J Med. 1995 Jan 26;332(4):201-8 [7808485] Medicine (Baltimore). 1995 Jul;74(4):212-20 [7623656] J Subst Abuse Treat. 1998 Mar-Apr;15(2):95-106 [9561947] J Acquir Immune Defic Syndr Hum Retrovirol. 1998;18 Suppl 1:S11-9 [9663618] JAMA. 1998 Aug 12;280(6):547-9 [9707146] J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Aug 15;18(5):435-43 [9715839] Science. 1999 Jul 2;285(5424):110-3 [10390360] J Neuroimmunol. 2004 Dec;157(1-2):56-60 [15579280] JAMA. 2004 Dec 15;292(23):2839-48 [15598915] J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1457-63 [15602123] Clin Infect Dis. 2005 Apr 15;40 Suppl 5:S321-4 [15768341] Gastroenterology. 2005 Aug;129(2):522-7 [16083709] Clin Infect Dis. 2005 Jul 1;41 Suppl 1:S32-7 [16265611] Clin Infect Dis. 2005 Jul 1;41 Suppl 1:S89-95 [16265622] AIDS Patient Care STDS. 2005 Dec;19(12):813-22 [16375613] Int Rev Psychiatry. 2005 Dec;17(6):471-6 [16401545] J Hepatol. 2006;44(1 Suppl):S56-9 [16343683] Am J Addict. 2006 Jan-Feb;15(1):23-34 [16449090] Drugs. 2006;66(2):155-74 [16451091] Am J Cardiol. 2006 Apr 1;97(7):1085-8 [16563922] Antivir Ther. 2006;11(4):397-408 [16856613] Gastroenterology. 2006 Aug;131(2):470-7 [16890601] AIDS Care. 2006 Oct;18(7):690-3 [16971276] Clin Infect Dis. 2006 Dec 15;43 Suppl 4:S224-34 [17109309] Clin Infect Dis. 2006 Dec 15;43 Suppl 4:S235-46 [17109310] AIDS. 2006 Nov 28;20(18):2361-9 [17117023] Arch Intern Med. 2007 Jan 22;167(2):148-54 [17242315] Subst Abuse Treat Prev Policy. 2007;2:4 [17222348] Am J Pathol. 2007 Feb;170(2):478-89 [17255316] Arch Intern Med. 2005 Mar 28;165(6):690-5 [15795348] Science. 2005 Jul 22;309(5734):623-6 [15947137] J Gastroenterol Hepatol. 1999 Nov;14(11):1100-7 [10574138] Med J Aust. 2000 Jan 17;172(2):57-61 [10738473] J Acquir Immune Defic Syndr. 2000 Apr 15;23(5):386-95 [10866231] Can J Public Health. 2000 Jul-Aug;91 Suppl 1:S18-21, S19-23 [11059125] AIDS. 2000 Sep;14 Suppl 2:S8-17 [11061637] J Acquir Immune Defic Syndr. 2000 Oct 1;25 Suppl 1:S49-52 [11126427] Am J Public Health. 2001 Jan;91(1):31-7 [11189820] Bipolar Disord. 2000 Sep;2(3 Pt 2):269-80 [11249805] Sex Transm Dis. 2001 Mar;28(3):166-70 [11289199] J Acquir Immune Defic Syndr. 2001 Jul 1;27(3):251-9 [11464144] AIDS. 2001 Sep 7;15(13):1707-15 [11546947] Lancet. 2001 Sep 22;358(9286):958-65 [11583749] JAMA. 2001 Dec 12;286(22):2857-64 [11735762] Am J Addict. 2001 Fall;10(4):296-307 [11783744] AIDS. 2002 Jun 14;16(9):1201-15 [12045485] J Gen Intern Med. 2002 May;17(5):377-81 [12047736] Pharmacotherapy. 2002 Jul;22(7):930-3 [12126226] Gastroenterology. 2002 Aug;123(2):476-82 [12145801] N Engl J Med. 2002 Sep 26;347(13):975-82 [12324553] Hepatology. 2002 Nov;36(5 Suppl 1):S201-9 [12407595] J Clin Pharmacol. 2002 Nov;42(11 Suppl):7S-10S [12412830] Am J Addict. 2002 Fall;11(4):271-8 [12584870] J Clin Virol. 2003 Feb;26(2):171-84 [12600649] Diabetes Care. 2003 Mar;26(3):917-32 [12610059] Clin Infect Dis. 2003 May 15;36(10):1318-23 [12746779] Nephrol Dial Transplant. 2003 Nov;18(11):2308-13 [14551358] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08897070802218661 ER - TY - JOUR T1 - Pharmacotherapy of methamphetamine addiction: an update. AN - 69839698; 19042205 AB - Methamphetamine dependence is a serious public health problem worldwide for which there are no approved pharmacological treatments. Psychotherapy is still the mainstay of treatment; however, relapse rates are high. The search for effective pharmacological treatment has intensified in the last decade. This review will highlight progress in pharmacological interventions to treat methamphetamine dependence as well as explore new pharmacological targets. Published data from clinical trials for stimulant addiction were searched using PubMed and summarized, as well as highlights from a recent symposium on methamphetamine pharmacotherapy presented at the ISAM 2006 meeting, including interim analysis data from an ongoing D-amphetamine study in Australia. Early pilot data are encouraging for administering D-amphetamine and methylphenidate as treatment for heavy amphetamine users. Abilify at 15 mg/day dose increased amphetamine use in an outpatient pilot study. Sertraline, ondansetron, baclofen, tyrosine, and imipramine were ineffective in proof-of-concept studies. Development of pharmacotherapy for methamphetamine dependence is still in an early stage. Data suggesting D-amphetamine and methylphenidate as effective pharmacotherapy for methamphetamine addiction will need to be confirmed by larger trials. Preclinical data suggest that use of GVG, CB1 antagonist, and lobeline are also promising therapeutic strategies. JF - Substance abuse AU - Elkashef, Ahmed AU - Vocci, Frank AU - Hanson, Glen AU - White, Jason AU - Wickes, Wendy AU - Tiihonen, Jari AD - Clinical Medical Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ae8a@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 31 EP - 49 VL - 29 IS - 3 SN - 0889-7077, 0889-7077 KW - Antipsychotic Agents KW - 0 KW - Central Nervous System Stimulants KW - Narcotic Antagonists KW - Nicotinic Agonists KW - Piperazines KW - Quinolones KW - Bupropion KW - 01ZG3TPX31 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Methamphetamine KW - 44RAL3456C KW - Aripiprazole KW - 82VFR53I78 KW - Lobeline KW - D0P25S3P81 KW - Dextroamphetamine KW - TZ47U051FI KW - Index Medicus KW - Dextroamphetamine -- therapeutic use KW - Nicotinic Agonists -- therapeutic use KW - Quinolones -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Bupropion -- therapeutic use KW - Piperazines -- therapeutic use KW - Humans KW - Antipsychotic Agents -- therapeutic use KW - Methylphenidate -- therapeutic use KW - Lobeline -- therapeutic use KW - Recurrence KW - Prevalence KW - Drug Therapy -- methods KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Pharmacotherapy+of+methamphetamine+addiction%3A+an+update.&rft.au=Elkashef%2C+Ahmed%3BVocci%2C+Frank%3BHanson%2C+Glen%3BWhite%2C+Jason%3BWickes%2C+Wendy%3BTiihonen%2C+Jari&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2008-01-01&rft.volume=29&rft.issue=3&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/10.1080%2F08897070802218554 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Synapse. 2001 Jul;41(1):22-8 [11354010] Pharmacol Rev. 2001 Jun;53(2):209-43 [11356984] J Pharmacol Exp Ther. 2001 Jul;298(1):172-9 [11408539] Nat Neurosci. 2001 Sep;4(9):873-4 [11528416] Addiction. 2001 Sep;96(9):1289-96 [11672493] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] J Neurosci. 2000 Aug 1;20(15):RC89 [10899176] Cochrane Database Syst Rev. 2002;(2):CD002025 [12076434] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11452-7 [12154229] J Neurochem. 2002 Sep;82(5):1171-8 [12358764] J Neurosci. 2002 Nov 1;22(21):9595-603 [12417684] Neuropsychopharmacology. 2003 Feb;28(2):329-38 [12589386] Synapse. 2003 Jun 1;48(3):154-6 [12645041] Mol Psychiatry. 2003 Apr;8(4):373-82 [12740594] Physiol Behav. 2003 Jun;79(1):121-8 [12818717] Neuropsychopharmacology. 2003 Jul;28(7):1272-80 [12700694] J Neurosci Res. 2003 Oct 1;74(1):91-6 [13130510] Ann N Y Acad Sci. 2003 Nov;1003:415-8 [14684476] Am J Psychiatry. 2004 Feb;161(2):242-8 [14754772] Psychopharmacology (Berl). 2004 Mar;172(2):170-8 [14624331] Alcohol Clin Exp Res. 2004 Apr;28(4):558-65 [15100606] Trends Pharmacol Sci. 2004 May;25(5):265-72 [15120493] J Neurosci. 2004 May 19;24(20):4723-7 [15152032] Am J Addict. 2004 May-Jun;13(3):248-55 [15370944] Psychopharmacology (Berl). 2004 Oct;176(1):57-65 [15083257] Med J Aust. 1990 Sep 3;153(5):306 [2392087] Nature. 1990 Sep 13;347(6289):146-51 [1975644] NIDA Res Monogr. 1991;115:84-98 [1758486] Br J Addict. 1992 Mar;87(3):439-46 [1559042] Addiction. 1994 Jan;89(1):79-85 [8148747] Acta Psychiatr Scand. 1994 Jun;89(6):428-32 [8085475] J R Soc Health. 1994 Jun;114(3):127-31 [7932481] Eur J Pharmacol. 1995 Aug 4;281(2):R7-9 [7589197] J Pharmacol Exp Ther. 1996 Sep;278(3):1128-37 [8819495] J Neurosci. 1997 Apr 1;17(7):2605-14 [9065520] Synapse. 1997 Apr;25(4):393-8 [9097399] Mol Psychiatry. 1997 Jan;2(1):5-6 [9154208] J Subst Abuse Treat. 1996 Nov-Dec;13(6):493-7 [9219147] Neuroreport. 1997 Jul 7;8(9-10):2373-7 [9243643] Pediatrics. 1997 Oct;100(4):662-6 [9310521] J Pharmacol Exp Ther. 1997 Oct;283(1):7-15 [9336302] Drug Alcohol Depend. 1997 Nov 25;48(2):113-8 [9363410] Psychopharmacology (Berl). 1998 May;137(2):184-90 [9630005] J Neurosci. 1998 Jul 15;18(14):5529-36 [9651233] Drug Alcohol Depend. 1998 Sep 1;52(1):79-84 [9788010] Nature. 1999 Jul 22;400(6742):371-5 [10432116] Aust N Z J Psychiatry. 1999 Aug;33(4):494-502 [10483843] J Clin Psychopharmacol. 2004 Dec;24(6):665-9 [15538132] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Psychopharmacology (Berl). 2005 Mar;178(2-3):296-302 [15452681] Neuron. 2005 Mar 3;45(5):647-50 [15748840] Neuropsychopharmacology. 2005 Apr;30(4):720-30 [15562293] Int J Neuropsychopharmacol. 2005 Jun;8(2):203-13 [15850499] Synapse. 2005 Jul;57(1):17-28 [15858839] J Med Chem. 2005 Jun 2;48(11):3663-79 [15916415] Am J Hypertens. 2005 Jun;18(6):813-22 [15925741] Neuroreport. 2005 Jun 21;16(9):1013-6 [15931079] Brain Res Brain Res Rev. 2005 Jul;49(1):77-105 [15960988] Drug Discov Today. 2005 Jul 1;10(13):917-25 [15993811] Behav Pharmacol. 2005 Sep;16(5-6):275-96 [16148435] Nature. 2005 Sep 22;437(7058):556-9 [16100511] Psychopharmacology (Berl). 2005 Nov;182(3):426-35 [16163531] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73 [16357203] Pharmacol Biochem Behav. 2005 Dec;82(4):704-11 [16413604] Drug Alcohol Depend. 2006 Oct 15;85(1):12-8 [16621339] Drug Alcohol Depend. 2006 Dec 1;85(3):177-84 [16740370] Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):123-30 [16978753] Am J Psychiatry. 2007 Jan;164(1):160-2 [17202560] Int J Neuropsychopharmacol. 2007 Feb;10(1):85-98 [16448579] Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):455-61 [17184890] Synapse. 2005 Feb;55(2):122-5 [15543630] Mol Pharmacol. 2005 Feb;67(2):349-55 [15548766] Ann N Y Acad Sci. 1999;897:27-45 [10676433] Addiction. 2000 Feb;95(2):229-38 [10723851] J Psychiatry Neurosci. 2000 Mar;25(2):125-36 [10740986] Neurology. 2000 Mar 28;54(6):1344-9 [10746608] Ann N Y Acad Sci. 2000;909:260-3 [10911936] Psychopharmacology (Berl). 2000 Jun;150(3):317-24 [10923760] Am J Addict. 2000 Summer;9(3):222-31 [11000918] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/08897070802218554 ER - TY - JOUR T1 - Stem cells and the mammary microenvironment. AN - 69820522; 19029625 AB - An entire mammary epithelial outgrowth, capable of full secretory differentiation, may comprise the progeny of a single cellular antecedent. This conclusion is based upon the maintenance of retroviral insertion sites within the somatic DNA of successive transplant generations derived from a single mammary fragment. In addition, dissociation of these clonal dominant glands and implantation of dispersed cells at limiting dilution demonstrated that both duct-limited and lobule-limited outgrowths were developed as well as complete, fully differentiated glands. Thus, transplantation has revealed three distinct mammary epithelial progenitors in the mouse. Recently, using cre-lox conditional activation of reporter genes, the lobule-limited progenitor was lineally marked by lacZ expression. In situ, these cells were shown to regenerate secretory lobules upon successive pregnancies. In transplant studies, they demonstrated the capacity for self- renewal and contributed to the new generation of all of the epithelial cell types among mammary secretory lobules. Using this conditional activation model, cells isolated from other tissues of the WAP-Cre/Rosa26/lacZReporter mice, co-mingled with normal wild type mammary epithelial cells and transplanted into epithelium-divested mammary fat pads, were shown to be amenable to redirection of their cell fate by interaction with the mammary microenvironment in vivo. This suggests the ascendancy of the microenvironment over the intrinsic nature of somatic stem cells. JF - Breast disease AU - Booth, Brian W AU - Boulanger, Corinne A AU - Smith, Gilbert H AD - Section for Mammary Stem Cell Biology, Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 57 EP - 67 VL - 29 KW - Index Medicus KW - Parity KW - Animals KW - Humans KW - Epithelium -- physiology KW - Mice KW - Cell Proliferation KW - Female KW - Pregnancy KW - Mutagenesis KW - Cell Division KW - Mammary Glands, Human -- physiology KW - Mammary Glands, Animal -- physiology KW - Stem Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69820522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+disease&rft.atitle=Stem+cells+and+the+mammary+microenvironment.&rft.au=Booth%2C+Brian+W%3BBoulanger%2C+Corinne+A%3BSmith%2C+Gilbert+H&rft.aulast=Booth&rft.aufirst=Brian&rft.date=2008-01-01&rft.volume=29&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Breast+disease&rft.issn=1558-1551&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Cell Dev Biol. 2005;21:605-31 [16212509] Development. 2005 Feb;132(4):681-7 [15647322] Breast Cancer Res. 2006;8(4):R49 [16882347] Dev Biol. 2007 Mar 1;303(1):29-44 [17222404] Gut. 2007 Mar;56(3):405-15 [16928726] Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3871-6 [17360445] Nat Protoc. 2006;1(1):206-14 [17406234] J Cell Physiol. 2007 Sep;212(3):729-36 [17443685] Nat Rev Cancer. 2007 Oct;7(10):791-9 [17851544] Curr Stem Cell Res Ther. 2006 Jan;1(1):21-7 [18220850] Oncogene. 2000 Feb 21;19(8):992-1001 [10713682] J Radiat Res. 1999 Dec;40 Suppl:128-37 [10805001] Microsc Res Tech. 2001 Jan 15;52(2):190-203 [11169867] Int J Cancer. 2001 May 15;92(4):568-76 [11304693] Oncogene. 2001 Apr 26;20(18):2264-72 [11402321] Development. 2002 Mar;129(6):1377-86 [11880347] Genes Dev. 2002 Mar 15;16(6):693-706 [11914275] Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10567-70 [12149477] Biochim Biophys Acta. 2002 Oct 2;1603(1):1-9 [12242106] Mech Ageing Dev. 2002 Sep;123(11):1505-19 [12425957] J Mammary Gland Biol Neoplasia. 2000 Oct;5(4):393-407 [14973384] Life Sci. 1965 May;4(9):993-1001 [5891495] Proc Natl Acad Sci U S A. 1968 Sep;61(1):53-60 [4301594] Exp Cell Res. 1971 Mar;65(1):27-32 [5549550] Exp Gerontol. 1971 Feb 1;6(1):49-56 [5572739] Exp Gerontol. 1971 Feb 1;6(1):95-101 [5572743] Fed Proc. 1975 Jan;34(1):64-7 [162797] Nature. 1975 May 15;255(5505):197-200 [1143315] Dev Biol. 1981 Nov;88(1):167-79 [7286443] J Cell Sci. 1982 Feb;53:97-114 [6806308] Dev Biol. 1983 Jun;97(2):274-90 [6852366] Cancer Res. 1984 Aug;44(8):3426-37 [6430550] Differentiation. 1985;29(2):127-35 [2412924] J Cell Sci. 1988 May;90 ( Pt 1):173-83 [3198708] J Virol. 1991 Nov;65(11):6365-70 [1656102] Carcinogenesis. 1993 Jan;14(1):25-8 [8425268] Breast Cancer Res Treat. 1996;39(1):21-31 [8738603] Tissue Cell. 1997 Apr;29(2):239-53 [9149446] Development. 1998 May;125(10):1921-30 [9550724] Proc Soc Exp Biol Med. 1998 Dec;219(3):217-25 [9824544] Cancer Res. 1959 Jun;19(5):515-20 [13663040] Science. 1965 Aug 6;149(3684):634-6 [14331183] Oncogene. 2005 Jan 20;24(4):552-60 [15580303] Isr Med Assoc J. 2006 Jun;8(6):430-4 [16833177] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Signal-averaged electrocardiogram in physically healthy, chronic 3,4-methylenedioxymethamphetamine (MDMA) users. AN - 69803732; 18855243 AB - 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) use has been associated with cardiac arrhythmias. Markers of ventricular late potentials (VLP), which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG), but not by standard ECG. We evaluated SA-ECG parameters in 21 physically healthy, recently abstinent MDMA users who also used cannabis (11 males, mean [SD] age 23.3 [4.6] years, 2.8 [2.0] years of use), 18 physically healthy cannabis users (8 males, mean [SD] age 26.6 [7.1] years, 11.2 [5.4] years of use) and 54 non-drug-using controls (21 males, mean [SD] age 28.4 [7.8] years). We analyzed three SA-ECG parameters considered markers of VLPs: duration of filtered QRS complex (fQRS), duration of low amplitude potentials during terminal 40 ms of QRS complex (LAS40), and root mean square voltage during terminal 40 ms of QRS complex (RMS40). MDMA users, cannabis users, and non-drug-using controls did not differ significantly from each other in fQRS, LAS40, or RMS40 values or in the proportion of subjects with abnormal SA-ECG parameters. There were significant gender differences among controls, but not among MDMA users. These findings suggest that chronic MDMA use is neither quantitatively nor qualitatively associated with a high prevalence of abnormal SA-ECG parameters indicative of VLP markers. JF - The American journal of drug and alcohol abuse AU - Kanneganti, Praveen AU - Huestis, Marilyn A AU - Kolbrich, Erin A AU - Goodwin, Robert AU - Ziegelstein, Roy C AU - Gorelick, David A AD - Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 712 EP - 720 VL - 34 IS - 6 KW - Hallucinogens KW - 0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Young Adult KW - Sex Factors KW - Humans KW - Adult KW - Marijuana Abuse -- physiopathology KW - Male KW - Female KW - Prevalence KW - Electrocardiography -- methods KW - Arrhythmias, Cardiac -- diagnosis KW - N-Methyl-3,4-methylenedioxyamphetamine -- adverse effects KW - Arrhythmias, Cardiac -- etiology KW - Hallucinogens -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69803732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Signal-averaged+electrocardiogram+in+physically+healthy%2C+chronic+3%2C4-methylenedioxymethamphetamine+%28MDMA%29+users.&rft.au=Kanneganti%2C+Praveen%3BHuestis%2C+Marilyn+A%3BKolbrich%2C+Erin+A%3BGoodwin%2C+Robert%3BZiegelstein%2C+Roy+C%3BGorelick%2C+David+A&rft.aulast=Kanneganti&rft.aufirst=Praveen&rft.date=2008-01-01&rft.volume=34&rft.issue=6&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=1097-9891&rft_id=info:doi/10.1080%2F00952990802308254 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Pharmacol Ther. 1971 Sep-Oct;12(5):762-8 [4936140] Ann Emerg Med. 2003 Sep;42(3):365-9 [12944889] N Engl J Med. 1987 Oct 22;317(17):1098 [3657876] Am J Forensic Med Pathol. 1988 Dec;9(4):339-41 [3239555] Acta Cardiol. 1992;47(5):435-43 [1441851] Pacing Clin Electrophysiol. 1994 Mar;17(3 Pt 1):303-11 [7513855] Pacing Clin Electrophysiol. 1994 Mar;17(3 Pt 2):446-50 [7513872] Br Heart J. 1994 Aug;72(2):197-200 [7917698] J Am Coll Cardiol. 1996 Jan;27(1):238-49 [8522703] J Clin Pathol. 1996 Feb;49(2):149-53 [8655682] J Pharmacol Exp Ther. 1999 Jul;290(1):136-45 [10381769] Emerg Med J. 2005 Sep;22(9):679-80 [16113206] Int J Cardiol. 2005 Sep 30;104(2):230-2 [16168820] Fundam Clin Pharmacol. 2006 Feb;20(1):1-8 [16448390] Int J Cardiol. 2007 May 31;118(2):141-4 [17005273] Am J Cardiol. 1990 Dec 1;66(19):1359-62 [2244568] Prog Cardiovasc Dis. 1992 Nov-Dec;35(3):169-88 [1438789] Obes Res. 2000 Jan;8(1):20-8 [10678255] Heart. 2000 Jun;83(6):627-33 [10814617] Ann Intern Med. 2000 Dec 19;133(12):969-73 [11119398] CMAJ. 2001 Oct 2;165(7):917-28 [11599334] Curr Womens Health Rep. 2002 Apr;2(2):83-8 [12116606] J Pharmacol Exp Ther. 2002 Sep;302(3):898-907 [12183645] J Clin Pharmacol. 2002 Nov;42(11 Suppl):58S-63S [12412837] JAMA. 1987 Mar 27;257(12):1615-7 [2881002] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/00952990802308254 ER - TY - JOUR T1 - Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. AN - 69739846; 18974851 AB - The resting EEG is a dynamic index of cortical activation, cognitive function and consciousness and is therefore an intermediate phenotype for many behaviors in which arousal is implicated such as anxiety and alcoholism. We performed a dense whole genome linkage scan using 3878 unlinked SNPs in a large pedigree derived from a population isolate sample of 328 Plains American Indians. Alpha (8-13 Hz), theta (4-8 Hz) and beta (13-30 Hz) EEG power was heritable (0.58-0.27) and stable over a 2 year period (r = 0.82-0.53). Genetic correlations between frequency bands were high (0.75). Linkage peaks for EEG power in all three frequency bands converged on chromosome 5q13-14 with genome-wide significant LOD scores of 3.5 (empirical p<0.0001) for alpha and beta power. A logical candidate gene, corticotropin releasing hormone-binding protein (CRH-BP), was located at the apex of these convergent linkage peaks. CRH-BP was significantly associated with alpha power in the Plains Indians and also in a replication sample of 188 Caucasians. Moreover, the same SNPs and haplotypes, located within the CRH-BP haplotype block, were also associated with anxiety disorders in the Plains Indians and alcohol use disorders in the Caucasians. CRH-BP modulates CRH which influences cortical and hippocampal EEG activity and is the primary mediator of the neuroendocrine stress response. Our results suggest a likely role for CRH-BP in stress-related alcoholism and highlight the use of the resting EEG as an intermediate phenotype for arousal-related behaviors such as anxiety and addiction. JF - PloS one AU - Enoch, Mary-Anne AU - Shen, Pei-Hong AU - Ducci, Francesca AU - Yuan, Qiaoping AU - Liu, Jixia AU - White, Kenneth V AU - Albaugh, Bernard AU - Hodgkinson, Colin A AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA. maenoch@niaaa.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1 VL - 3 IS - 10 KW - Carrier Proteins KW - 0 KW - corticotropin releasing factor-binding protein KW - 134773-81-2 KW - Index Medicus KW - Quantitative Trait, Heritable KW - Phenotype KW - Environment KW - Polymorphism, Single Nucleotide KW - Rest -- physiology KW - Humans KW - Linkage Disequilibrium KW - Brain -- physiology KW - Genome-Wide Association Study KW - Chromosomes, Human, Pair 5 KW - Carrier Proteins -- genetics KW - Anxiety -- genetics KW - Electroencephalography KW - Alcoholism -- ethnology KW - Carrier Proteins -- physiology KW - Anxiety -- ethnology KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69739846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Common+genetic+origins+for+EEG%2C+alcoholism+and+anxiety%3A+the+role+of+CRH-BP.&rft.au=Enoch%2C+Mary-Anne%3BShen%2C+Pei-Hong%3BDucci%2C+Francesca%3BYuan%2C+Qiaoping%3BLiu%2C+Jixia%3BWhite%2C+Kenneth+V%3BAlbaugh%2C+Bernard%3BHodgkinson%2C+Colin+A%3BGoldman%2C+David&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2008-01-01&rft.volume=3&rft.issue=10&rft.spage=e3620&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0003620 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neuron. 2002 Jan 31;33(3):325-40 [11832222] Alcohol Alcohol. 2008 Sep-Oct;43(5):505-15 [18477577] Biol Psychiatry. 2002 Oct 15;52(8):831-42 [12372655] Biol Psychol. 2002 Oct;61(1-2):111-38 [12385672] Neuroreport. 2002 Dec 20;13(18):2487-92 [12499854] Am J Med Genet B Neuropsychiatr Genet. 2003 Apr 1;118B(1):66-71 [12627469] Alcohol Clin Exp Res. 2003 Apr;27(4):607-15 [12711923] Neuron. 2003 Jul 31;39(3):401-7 [12895416] Am J Hum Genet. 2003 Nov;73(5):1162-9 [14574645] Int J Psychophysiol. 2004 Feb;51(3):239-51 [14962576] Am J Hum Genet. 2004 Apr;74(4):705-14 [15024690] J Neurosci. 2004 Oct 27;24(43):9703-13 [15509759] Humangenetik. 1970 Sep 17;10(2):91-114 [5528299] Electroencephalogr Clin Neurophysiol. 1979 Feb;46(2):224-6 [86431] J Neural Transm. 1987;70(3-4):183-91 [2445911] Biol Psychiatry. 1990 Mar 15;27(6):631-41 [2322623] J Clin Neurophysiol. 1990 Apr;7(2):191-207 [2187020] Electroencephalogr Clin Neurophysiol. 1991 Jul;79(1):20-6 [1713548] Electroencephalogr Clin Neurophysiol. 1991 Nov;79(5):382-92 [1718711] Genomics. 1992 Jan;12(1):69-73 [1346390] Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11595-600 [10500222] J Neurophysiol. 2005 May;93(5):2864-72 [15601739] Hum Hered. 2005;60(2):119-22 [16224189] Brain Res Brain Res Rev. 2005 Nov;49(3):505-28 [16269317] Psychophysiology. 2005 Nov;42(6):691-7 [16364064] Psychophysiology. 2000 Mar;37(2):127-52 [10731765] Neuroscience. 2000;101(1):115-29 [11068141] Int J Psychophysiol. 2000 Dec 1;38(3):315-36 [11102670] Int J Psychophysiol. 2001 Jan;39(2-3):241-8 [11163901] Neuropsychopharmacology. 2001 Sep;25(3):332-40 [11522462] Prog Neurobiol. 1992 Oct;39(4):337-88 [1354387] Neurosci Lett. 1993 Dec 24;164(1-2):81-4 [8152620] Brain Res Bull. 1994;35(5-6):597-605 [7859117] Nat Genet. 1995 Nov;11(3):241-7 [7581446] Am J Hum Genet. 1996 Mar;58(3):562-73 [8644716] J Neurochem. 1997 May;68(5):2053-60 [9109532] J Clin Endocrinol Metab. 1997 May;82(5):1566-71 [9141551] Am J Hum Genet. 1998 May;62(5):1198-211 [9545414] Am J Hum Genet. 1998 Jul;63(1):259-66 [9634505] Alcohol Clin Exp Res. 1999 Feb;23(2):256-62 [10069554] J Clin Endocrinol Metab. 1999 Aug;84(8):2788-94 [10443681] Alcohol Clin Exp Res. 1999 Aug;23(8):1312-9 [10470973] J Neurosci. 1999 Oct 1;19(19):8637-45 [10493764] Front Biosci. 2006;11:1878-91 [16368564] Biol Psychol. 2006 Mar;71(3):289-95 [16054745] Int J Psychophysiol. 2006 Aug;61(2):235-43 [16338015] Biol Psychiatry. 2007 Jan 1;61(1):119-26 [17081504] Behav Genet. 2007 Mar;37(2):302-13 [17180712] Int J Psychophysiol. 2007 Apr;64(1):18-23 [16997407] Int J Psychophysiol. 2007 Apr;64(1):3-17 [17000018] Biol Psychol. 2007 May;75(2):154-64 [17316957] Psychopharmacology (Berl). 2007 Aug;193(2):283-94 [17437087] Int J Neuropsychopharmacol. 2008 Aug;11(5):625-39 [18205979] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3729-33 [11891318] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0003620 ER - TY - JOUR T1 - Gene-environment interactions in environmental lung diseases. AN - 69731092; 18972752 AB - Lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and acute respiratory distress syndrome (ARDS) have complex etiologies. It is generally agreed that genetic background has an important role in susceptibility to these diseases, and the genetic contribution to disease phenotypes varies between populations. Linkage analyses have identified some predisposing genes. However, genetic background cannot account for all of the inter-individual variation in disease susceptibility. Interaction between genetic background and exposures to environmental stimuli, and understanding of the mechanisms through which environmental exposure interact with susceptibility genes, is critical to disease prevention. Use of animal models, particularly inbred mice, has provided important insight to understand human disease etiologies because genetic background and environmental exposures can be controlled. We have utilized a positional cloning approach in inbred mice to identify candidate susceptibility genes for oxidant-induced lung injury. Subsequent investigations with cell models identified functional polymorphisms in human homologues that confer enhanced risk of lung injury in humans. This 'bench to bedside' approach may provide an understanding of gene-environment interactions in complex lung diseases is essential to the development of new strategies for lung disease prevention and treatment. JF - Novartis Foundation symposium AU - Kleeberger, Steven R AU - Cho, Hye-Youn AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 168 EP - 78; discussion 178-83 VL - 293 SN - 1528-2511, 1528-2511 KW - NF-E2-Related Factor 2 KW - 0 KW - Oxidants KW - Index Medicus KW - Animals KW - Polymorphism, Single Nucleotide KW - Oxidants -- adverse effects KW - Base Sequence KW - Environmental Illness -- genetics KW - Humans KW - NF-E2-Related Factor 2 -- genetics KW - Molecular Sequence Data KW - Mice KW - Genetic Predisposition to Disease KW - Environmental Exposure -- adverse effects KW - Environment KW - Lung Diseases -- etiology KW - Genes -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69731092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Novartis+Foundation+symposium&rft.atitle=Gene-environment+interactions+in+environmental+lung+diseases.&rft.au=Kleeberger%2C+Steven+R%3BCho%2C+Hye-Youn&rft.aulast=Kleeberger&rft.aufirst=Steven&rft.date=2008-01-01&rft.volume=293&rft.issue=&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Novartis+Foundation+symposium&rft.issn=15282511&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-04 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational hazards and illnesses of Filipino women workers in export processing zones. AN - 69719724; 18954543 AB - This was a baseline study on occupational exposure and health problems among women workers in export processing zones. Physical, chemical, and ergonomic hazards were evaluated and measured through workplace ambient monitoring, survey questionnaires, and interviews with 500 respondents in 24 companies (most were female at 88.8%). The top 5 hazards were ergonomic hazards (72.2%), heat (66.6%), overwork (66.6%), poor ventilation (54.8%), and chemical exposure (50.8%). The most common illnesses were gastrointestinal problems (57.4%), backache (56%), headache (53.2%), and fatigue/weakness (53.2%). Logistic regression showed an association between certain work-related factors and occupational illnesses, and psychosocial problems. Highly significant associations were hearing loss with years spent in the company (p=.005) and gender (p=.006), headache and dizziness with poor ventilation (p=.000), backache with prolonged work (p=.003). These results will have implications for policy and program formulation for women workers' concerns and issues in export zones. JF - International journal of occupational safety and ergonomics : JOSE AU - Lu, Jinky Leilanie AD - National Institutes of Health, University of the Philippines, Manila, the Philippines. jinky_lu@yahoo.com Y1 - 2008 PY - 2008 DA - 2008 SP - 333 EP - 342 VL - 14 IS - 3 SN - 1080-3548, 1080-3548 KW - Dust KW - 0 KW - Index Medicus KW - Occupational Exposure KW - Ventilation KW - Humans KW - Workplace KW - Philippines -- epidemiology KW - Back Pain -- epidemiology KW - Dizziness -- epidemiology KW - Logistic Models KW - Risk Factors KW - Hypertension -- epidemiology KW - Adult KW - Headache -- epidemiology KW - Gastrointestinal Diseases -- epidemiology KW - Female KW - Male KW - Occupational Health KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69719724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+occupational+safety+and+ergonomics+%3A+JOSE&rft.atitle=Occupational+hazards+and+illnesses+of+Filipino+women+workers+in+export+processing+zones.&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2008-01-01&rft.volume=14&rft.issue=3&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=International+journal+of+occupational+safety+and+ergonomics+%3A+JOSE&rft.issn=10803548&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-25 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute aortic dissection in a hypertensive patient with prostate cancer undergoing chemotherapy containing bevacizumab. AN - 69709182; 18607842 JF - Acta oncologica (Stockholm, Sweden) AU - Aragon-Ching, Jeanny B AU - Ning, Yang-Min AU - Dahut, William L AD - Medical Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 1600 EP - 1601 VL - 47 IS - 8 KW - Angiogenesis Inhibitors KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Vascular Endothelial Growth Factor A KW - Bevacizumab KW - 2S9ZZM9Q9V KW - Index Medicus KW - Vascular Endothelial Growth Factor A -- antagonists & inhibitors KW - Humans KW - Tomography, X-Ray Computed KW - Aged KW - Male KW - Hypertension -- complications KW - Aneurysm, Dissecting -- drug therapy KW - Aortic Aneurysm -- pathology KW - Aortic Aneurysm -- drug therapy KW - Aneurysm, Dissecting -- pathology KW - Aneurysm, Dissecting -- chemically induced KW - Prostatic Neoplasms -- surgery KW - Aortic Aneurysm -- chemically induced KW - Antibodies, Monoclonal -- adverse effects KW - Angiogenesis Inhibitors -- adverse effects KW - Prostatic Neoplasms -- drug therapy KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69709182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.atitle=Acute+aortic+dissection+in+a+hypertensive+patient+with+prostate+cancer+undergoing+chemotherapy+containing+bevacizumab.&rft.au=Aragon-Ching%2C+Jeanny+B%3BNing%2C+Yang-Min%3BDahut%2C+William+L&rft.aulast=Aragon-Ching&rft.aufirst=Jeanny&rft.date=2008-01-01&rft.volume=47&rft.issue=8&rft.spage=1600&rft.isbn=&rft.btitle=&rft.title=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.issn=1651-226X&rft_id=info:doi/10.1080%2F02841860801978905 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-11 N1 - Date created - 2008-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/02841860801978905 ER - TY - JOUR T1 - Low-dose lung computed tomography screening before age 55: estimates of the mortality reduction required to outweigh the radiation-induced cancer risk. AN - 69675133; 18927099 AB - To estimate the risk of radiation-induced lung cancer mortality from three annual low-dose lung computed tomography (CT) screens before age 55 years (starting at age 30, 40 or 50) and the mortality reduction from screening (i.e. the efficacy) needed to outweigh these risks for never and current-smokers. The risk of radiation-induced breast cancer was also estimated for women. The Biological Effectiveness of Ionizing Radiation VII committee's risk models were used to estimate radiation risk. Lung cancer mortality rates (based on the Bach model for current and the Cancer Prevention Study for never-smokers) were used to estimate the mortality reduction needed to outweigh this risk. For never-smokers, the estimated excess lifetime risk of radiation-induced lung cancer mortality from annual screening aged 40-42 was 1/10,000 (90% credibility interval: 0.4-3) for men and 3/10,000 (2-6) for women. For current-smokers, the estimated risks were approximately two-fold higher, with wider credibility intervals. Risks from screening age 30-32 or 50-52 years were of similar magnitude. The mortality reduction required to outweigh these risks was, for female never-smokers: 125% (40-300%) age 30-32 years, 70% (30-190%) age 40-42 years and 25% (10-70%) age 50-52 years, and for male current-smokers: 70% (20-120%) age 30-32 years, 10% (3-20%) age 40-42 years and 2% (1-4%) age 50-52 years. These figures were two to three times higher for females because of the higher radiation risks. The risk of radiation-induced breast cancer was in the range of three to six cases/10,000 females screened. Before age 50, the mortality reduction from lung CT screening that is required to outweigh the radiation risk may be substantial, and in some cases unattainable (i.e. >100%). JF - Journal of medical screening AU - Berrington de González, Amy AU - Kim, Kwang Pyo AU - Berg, Christine D AD - Division of Cancer Epidemiology & Biostatistics, National Cancer Institute, Bethesda, MD 20892, USA. berringtona@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 153 EP - 158 VL - 15 IS - 3 SN - 0969-1413, 0969-1413 KW - Index Medicus KW - Software KW - Humans KW - Adult KW - Smoking -- adverse effects KW - Middle Aged KW - Male KW - Female KW - Risk Assessment KW - Tomography, X-Ray Computed -- methods KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- epidemiology KW - Neoplasms, Radiation-Induced -- etiology KW - Lung -- diagnostic imaging KW - Tomography, X-Ray Computed -- adverse effects KW - Neoplasms, Radiation-Induced -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69675133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+screening&rft.atitle=Low-dose+lung+computed+tomography+screening+before+age+55%3A+estimates+of+the+mortality+reduction+required+to+outweigh+the+radiation-induced+cancer+risk.&rft.au=Berrington+de+Gonz%C3%A1lez%2C+Amy%3BKim%2C+Kwang+Pyo%3BBerg%2C+Christine+D&rft.aulast=Berrington+de+Gonz%C3%A1lez&rft.aufirst=Amy&rft.date=2008-01-01&rft.volume=15&rft.issue=3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+screening&rft.issn=09691413&rft_id=info:doi/10.1258%2Fjms.2008.008052 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiat Res. 2002 Aug;158(2):220-35 [12105993] Radiology. 2008 Jul;248(1):278-87 [18458247] Radiat Res. 2003 Feb;159(2):161-73 [12537521] J Natl Cancer Inst. 2003 Mar 19;95(6):470-8 [12644540] Radiat Res. 2003 Apr;159(4):511-20 [12643796] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13761-6 [14610281] Radiology. 2004 May;231(2):440-5 [15128988] BMJ. 2004 Jun 26;328(7455):1519 [15213107] J Epidemiol Community Health. 1978 Dec;32(4):303-13 [744822] Cancer Res. 1989 Nov 1;49(21):6130-6 [2790825] J Clin Epidemiol. 1994 Dec;47(12):1451-61 [7730854] Radiat Res. 1995 Jun;142(3):295-304 [7761580] J Natl Cancer Inst. 1995 Oct 18;87(20):1530-7 [7563187] Lung Cancer. 2005 Jan;47(1):9-15 [15603850] Natl Vital Stat Rep. 2005 Feb 28;53(15):1-48 [15779680] Br J Cancer. 2005 Sep 5;93(5):590-6 [16136033] J Natl Cancer Inst. 2006 May 3;98(9):637-40 [16670389] J Natl Cancer Inst. 2006 May 17;98(10):691-9 [16705123] N Engl J Med. 2006 Oct 26;355(17):1763-71 [17065637] Acad Radiol. 2006 Nov;13(11):1431-41 [17111584] Lancet. 2006 Dec 9;368(9552):2053-60 [17161727] Thorax. 2007 Feb;62(2):126-30 [17101739] JAMA. 2007 Mar 7;297(9):953-61 [17341709] J Natl Cancer Inst. 2007 May 2;99(9):715-26 [17470739] J Clin Oncol. 2008 Jan 20;26(3):392-8 [18202415] Int J Cancer. 2008 Jun 1;122(11):2594-9 [18302157] Br J Cancer. 2008 May 20;98(10):1602-7 [18475292] Rofo. 2002 Dec;174(12):1570-6 [12471531] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1258/jms.2008.008052 ER - TY - JOUR T1 - DNA cleavage assay for the identification of topoisomerase I inhibitors. AN - 69671948; 18927559 AB - The inhibition of DNA topoisomerase I (Top1) has proven to be a successful approach in the design of anticancer agents. However, despite the clinical successes of the camptothecin derivatives, a significant need for less toxic and more chemically stable Top1 inhibitors still persists. Here, we describe one of the most frequently used protocols to identify novel Top1 inhibitors. These methods use uniquely 3'-radiolabeled DNA substrates and denaturing polyacrylamide gel electrophoresis to provide evidence for the Top1-mediated DNA cleaving activity of potential Top1 inhibitors. These assays allow comparison of the effectiveness of different drugs in stabilizing the Top1-DNA intermediate or cleavage (cleavable) complex. A variation on these assays is also presented, which provides a suitable system for determining whether the inhibitor blocks the forward cleavage or religation reactions by measuring the reversibility of the drug-induced Top1-DNA cleavage complexes. This entire protocol can be completed in approximately 2 d. JF - Nature protocols AU - Dexheimer, Thomas S AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 1736 EP - 1750 VL - 3 IS - 11 KW - Enzyme Inhibitors KW - 0 KW - Topoisomerase I Inhibitors KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Index Medicus KW - DNA Topoisomerases, Type I -- chemistry KW - Sequence Analysis, DNA -- methods KW - Nucleic Acid Denaturation KW - Humans KW - Electrophoresis, Polyacrylamide Gel -- methods KW - 3' Flanking Region KW - Isotope Labeling KW - Structure-Activity Relationship KW - Enzyme Inhibitors -- chemistry KW - Drug Screening Assays, Antitumor -- methods KW - DNA Cleavage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69671948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+protocols&rft.atitle=DNA+cleavage+assay+for+the+identification+of+topoisomerase+I+inhibitors.&rft.au=Dexheimer%2C+Thomas+S%3BPommier%2C+Yves&rft.aulast=Dexheimer&rft.aufirst=Thomas&rft.date=2008-01-01&rft.volume=3&rft.issue=11&rft.spage=1736&rft.isbn=&rft.btitle=&rft.title=Nature+protocols&rft.issn=1750-2799&rft_id=info:doi/10.1038%2Fnprot.2008.174 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nprot.2008.174 ER - TY - JOUR T1 - Dopamine/serotonin releasers as medications for stimulant addictions. AN - 69524934; 18772043 AB - The use of 'agonist therapy' for cocaine and methamphetamine addiction involves administration of stimulant-like medications (e.g. monoamine releasers) to reduce withdrawal symptoms and prevent relapse. A significant problem with this strategy is that many candidate medications possess abuse liability due to activation of mesolimbic dopamine (DA) neurons in the brain. One way to reduce DA-mediated abuse liability of candidate drugs might be to add in serotonin (5-HT)-releasing properties, since substantial evidence shows that 5-HT neurons provide an inhibitory influence over mesolimbic DA neurons. This chapter addresses several key issues related to the development of dual DA/5-HT releasers for the treatment of substance use disorders. First, we briefly summarize the evidence supporting a dual deficit in DA and 5-HT function during withdrawal from chronic cocaine or alcohol abuse. Second, we discuss data demonstrating that 5-HT release can dampen DA-mediated stimulant effects, and the 'anti-stimulant' role of 5-HT(2C) receptors is considered. Next, the mechanisms underlying potential adverse effects of 5-HT releasers are described. Finally, we discuss recently published data with PAL-287, a novel non-amphetamine DA/5-HT-releasing agent that suppresses cocaine self-administration but lacks positive reinforcing properties. It is concluded that DA/5-HT releasers could be useful therapeutic adjuncts for the treatment of cocaine and alcohol addictions as well as for obesity, attention deficit disorder and depression. JF - Progress in brain research AU - Rothman, Richard B AU - Blough, Bruce E AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD, USA. rrothman@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 385 EP - 406 VL - 172 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Agents KW - Dopamine Uptake Inhibitors KW - Receptors, Serotonin KW - Serotonin Uptake Inhibitors KW - Fenfluramine KW - 2DS058H2CF KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Phentermine KW - C045TQL4WP KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Molecular Structure KW - Animals KW - Neurons -- metabolism KW - Serotonin Uptake Inhibitors -- metabolism KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Humans KW - Fenfluramine -- therapeutic use KW - Receptors, Serotonin -- metabolism KW - Central Nervous System Stimulants -- chemistry KW - Phentermine -- therapeutic use KW - Dopamine Agents -- metabolism KW - Dopamine Agents -- therapeutic use KW - Fenfluramine -- metabolism KW - Central Nervous System Stimulants -- metabolism KW - Phentermine -- metabolism KW - Methamphetamine -- metabolism KW - Methamphetamine -- chemistry KW - Substance-Related Disorders -- drug therapy KW - Dopamine Uptake Inhibitors -- therapeutic use KW - Dopamine -- metabolism KW - Cocaine -- chemistry KW - Behavior, Addictive -- drug therapy KW - Serotonin -- metabolism KW - Cocaine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69524934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+brain+research&rft.atitle=Dopamine%2Fserotonin+releasers+as+medications+for+stimulant+addictions.&rft.au=Rothman%2C+Richard+B%3BBlough%2C+Bruce+E%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2008-01-01&rft.volume=172&rft.issue=&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Progress+in+brain+research&rft.issn=1875-7855&rft_id=info:doi/10.1016%2FS0079-6123%2808%2900919-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0079-6123(08)00919-9 ER - TY - JOUR T1 - [Risk factors of near-fatal deliberate self-harm behavior in self-cutting patients: a three-year follow-up study at a psychiatric clinic]. AN - 69452413; 18717158 AB - Non-fatal self-injurious behavior such as cutting oneself is often performed without suicidal intent to cope with emotional distress, although it is well-known to have a close association with future suicidal behavior. However, it is unclear what kinds of clinical features are presented by such self-injuring patients with a higher suicidal tendency. In the present study, we conducted a three-year follow-up study of female self-injuring patients to examine the risk factors of "near-fatal" deliberate self-harm behavior (DSH). The subjects were 81 female outpatients who had cut themselves at least once, and who had consulted a psychiatric clinic from June 2004 to July 2004. Initial assessments included traumatic life events, clinical features of self-cutting, histories of self-poisoning, alcohol abuse (Alcohol Use Disorders Identification Test: AUDIT), impulsivity (Barratt Impulsiveness Scale, 11th version: BIS-11), symptoms of bulimia nervosa (Bulimia Investigatory Test, Edinburgh: BITE), dissociation (Adolescent Dissociative Experience Scale: ADES), Global Assessment of Functioning (GAF) score, and axis I diagnosis of DSM-IV (Diagnostic and Statistical Manual, 4th version). After three years, we investigated whether the subjects had committed fatal DSH during the follow-up term. We obtained information on fatal DSH from 67 subjects during the follow-up term. Fifteen of the 67 (22.4%) had committed near-fatal DSH at least once, and one subject committed suicide by fatal DSH. Monovariate analysis revealed that in the initial assessment, the subjects with near-fatal DSH episodes more frequently reported a history of victimization by rape in adulthood and a history of OTC (over-the-counter) drug self-poisoning, and had higher scores on the BITE and AUDIT than those without near-fatal DSH episodes. Further, multivariate analysis demonstrated that only the BITE score was a significant factor in predicting future near-fatal DSH. In conclusion, symptoms of bulimia nervosa may have important clinical implications. The BITE may be a useful tool to assess future suicidal behavior in female self-cutting patients. JF - Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica AU - Matsumoto, Toshihiko AU - Azekawa, Takaharu AU - Itami, Akira AU - Takeshima, Tadashi AD - National Institute of Mental Health, National Center of Neurology and Psychiatry. Y1 - 2008 PY - 2008 DA - 2008 SP - 475 EP - 487 VL - 110 IS - 6 SN - 0033-2658, 0033-2658 KW - Index Medicus KW - Alcohol-Related Disorders -- complications KW - Bulimia Nervosa -- epidemiology KW - Risk Factors KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Bulimia Nervosa -- complications KW - Suicide KW - Follow-Up Studies KW - Time Factors KW - Female KW - Alcohol-Related Disorders -- epidemiology KW - Self-Injurious Behavior -- psychology KW - Self-Injurious Behavior -- epidemiology KW - Self-Injurious Behavior -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69452413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seishin+shinkeigaku+zasshi+%3D+Psychiatria+et+neurologia+Japonica&rft.atitle=%5BRisk+factors+of+near-fatal+deliberate+self-harm+behavior+in+self-cutting+patients%3A+a+three-year+follow-up+study+at+a+psychiatric+clinic%5D.&rft.au=Matsumoto%2C+Toshihiko%3BAzekawa%2C+Takaharu%3BItami%2C+Akira%3BTakeshima%2C+Tadashi&rft.aulast=Matsumoto&rft.aufirst=Toshihiko&rft.date=2008-01-01&rft.volume=110&rft.issue=6&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Seishin+shinkeigaku+zasshi+%3D+Psychiatria+et+neurologia+Japonica&rft.issn=00332658&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-02 N1 - Date created - 2008-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Awareness of hormesis will enhance future research in basic and applied neuroscience. AN - 69436509; 18709572 AB - Hormesis is defined operationally as responses of cells or organisms to an exogenous or intrinsic factor (chemical, temperature, psychological challenge, etc.) in which the factor induces stimulatory or beneficial effects at low doses and inhibitory or adverse effects at high doses. The compendium of articles by Calabrese entitled "Neuroscience and Hormesis" provides a broad range of examples of neurobiological processes and responses to environmental factors that exhibit biphasic dose responses, the signature of hormesis. Nerve cell networks are the "first responders" to environmental challenges--they perceive the challenge and orchestrate coordinated adaptive responses that typically involve autonomic, neuroendocrine, and behavioral changes. In addition to direct adaptive responses of neurons to environmental stressors, cells subjected to a stressor produce and release molecules such as growth factors, cytokines, and hormones that alert adjacent and even distant cells to impending danger. The discoveries that some molecules (e.g., carbon monoxide and nitric oxide) and elements (e.g., selenium and iron) that are toxic at high doses play fundamental roles in cellular signaling or metabolism suggest that during evolution, organisms (and their nervous systems) co-opted environmental toxins and used them to their advantage. Neurons also respond adaptively to everyday stressors, including physical exercise, cognitive challenges, and dietary energy restriction, each of which activates pathways linked to the production of neurotrophic factors and cellular stress resistance proteins. The development of interventions that activate hormetic signaling pathways in neurons is a promising new approach for the preventation and treatment of a range of neurological disorders. JF - Critical reviews in toxicology AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA. mattsonm@grc.nia.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 633 EP - 639 VL - 38 IS - 7 KW - Xenobiotics KW - 0 KW - Index Medicus KW - Animals KW - Biomedical Research KW - Humans KW - Neuropharmacology -- methods KW - Adaptation, Physiological -- drug effects KW - Dose-Response Relationship, Drug KW - Nerve Net -- metabolism KW - Nerve Net -- drug effects KW - Xenobiotics -- toxicity KW - Nervous System Physiological Phenomena UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69436509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Awareness+of+hormesis+will+enhance+future+research+in+basic+and+applied+neuroscience.&rft.au=Mattson%2C+Mark+P&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2008-01-01&rft.volume=38&rft.issue=7&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+toxicology&rft.issn=1547-6898&rft_id=info:doi/10.1080%2F10408440802026406 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-07 N1 - Date created - 2008-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2002 Sep;82(6):1367-75 [12354284] Neuropharmacology. 2002 Sep;43(3):357-66 [12243765] J Neurosci Res. 1999 Sep 15;57(6):830-9 [10467254] Learn Mem. 1998 Nov-Dec;5(6):467-80 [10489262] Ageing Res Rev. 2004 Nov;3(4):445-64 [15541711] Free Radic Biol Med. 2004 Dec 15;37(12):1995-2011 [15544918] Mol Aspects Med. 2005 Feb-Apr;26(1-2):67-96 [15722115] Curr Med Chem. 2005;12(3):267-75 [15723618] Curr Drug Targets CNS Neurol Disord. 2005 Apr;4(2):121-5 [15857297] Curr Biol. 2005 May 24;15(10):929-34 [15916949] NeuroRx. 2004 Jan;1(1):111-6 [15717011] J Neurosci. 2005 Sep 21;25(38):8680-5 [16177036] Clin Exp Pharmacol Physiol. 2006 Apr;33(4):395-9 [16620308] Neuromolecular Med. 2006;8(3):389-414 [16775390] Ageing Res Rev. 2006 Aug;5(3):332-53 [16899414] Trends Neurosci. 2006 Nov;29(11):632-9 [17000014] J Appl Physiol (1985). 2006 Dec;101(6):1776-82 [16959909] Curr Biol. 2006 Nov 21;16(22):R958-60 [17113376] Diabetologia. 2007 Jan;50(1):8-17 [17119917] Expert Opin Ther Targets. 2007 Feb;11(2):123-32 [17227229] J Nutr. 2007 Apr;137(4):1078-86 [17374682] Nat Neurosci. 2007 May;10(5):559-67 [17396124] Emerg Med Clin North Am. 2007 May;25(2):567-95; abstract xi [17482033] Trends Neurosci. 2007 Sep;30(9):464-72 [17765329] Ageing Res Rev. 2008 Jan;7(1):49-62 [17604236] Trends Neurosci. 2003 Feb;26(2):81-9 [12536131] Eur J Pharmacol. 2003 Feb 28;463(1-3):235-72 [12600714] Curr Opin Plant Biol. 2003 Apr;6(2):185-90 [12667877] Free Radic Biol Med. 2003 Apr 15;34(8):955-68 [12684081] Neuromolecular Med. 2003;3(2):65-94 [12728191] J Nutr. 2003 Jun;133(6):1921-9 [12771340] Crit Rev Toxicol. 2003;33(3-4):443-9 [12809433] Sci Aging Knowledge Environ. 2003 Feb 26;2003(8):RE2 [12844547] Am Heart J. 2003 Jul;146(1):160-7 [12851626] Cell Calcium. 2003 Oct-Nov;34(4-5):385-97 [12909083] Nat Med. 2003 Sep;9(9):1113-5 [12949521] Nature. 2003 Sep 11;425(6954):191-6 [12939617] Bioessays. 2004 Mar;26(3):270-80 [14988928] J Postgrad Med. 2004 Apr-Jun;50(2):145-9 [15235216] Ann N Y Acad Sci. 2004 Jun;1018:1-15 [15240347] Mol Microbiol. 2004 Aug;53(4):1003-9 [15306006] Trends Neurosci. 2004 Oct;27(10):589-94 [15374669] FASEB J. 2004 Oct;18(13):1499-506 [15466358] Am J Physiol Renal Physiol. 2004 Nov;287(5):F979-89 [15292046] Rev Physiol Biochem Pharmacol. 1975;74:1-103 [1841] Brain Res. 1988 Apr-Jun;472(2):179-212 [2898278] Ann Intern Med. 1994 Feb 1;120(3):227-37 [8273987] Br J Pharmacol. 1997 Jul;121(5):927-34 [9222549] Gen Pharmacol. 1998 Nov;31(5):667-74 [9809461] Nat Med. 1999 Apr;5(4):448-53 [10202938] Nat Toxins. 1998;6(3-4):153-8 [10223631] Eur J Nutr. 2000 Apr;39(2):53-61 [10918985] Neuroscience. 2000;99(4):587-92 [10974422] J Clin Invest. 2001 Feb;107(3):247-54 [11160145] Nature. 2001 Mar 8;410(6825):227-30 [11242085] J Clin Invest. 2001 May;107(9):1163-71 [11342580] Biometals. 2001 Jun;14(2):99-112 [11508852] J Neurosci. 2001 Dec 1;21(23):9204-13 [11717354] JAMA. 2002 Feb 13;287(6):742-8 [11851541] J Biol Chem. 2002 May 17;277(20):17950-61 [11880364] Cell Signal. 2002 Aug;14(8):649-54 [12020764] Plant J. 2002 Aug;31(4):387-406 [12182699] Genetics. 1999 Aug;152(4):1277-83 [10430558] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10408440802026406 ER - TY - JOUR T1 - Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study. AN - 69420061; 18697567 AB - Tumor cells intensely utilize glutamine as the major source of respiratory fuel. Glutamine-analogue acivicin inhibits tumor growth and tumor-induced angiogenesis in Ehrlich ascites carcinoma. In the present study, antitumor properties of acivicin in combination with glutaminase enzyme is reported. Acivicin along with E. coli glutaminase synergistically reduced in vitro proliferation and matrigel invasion of human MCF-7 and OAW-42 cells. Effects of single and combined treatments with acivicin and glutaminase on angiogenic factors were also analyzed in these cell lines. Co-administration of the treatment agents inhibits the release of VEGF and MMP-9 by cells in culture supernatant significantly than single agent treatments. The result suggests that combination of acivicin with glutaminase may provide a better therapeutic option than either of them given separately for treating human breast and ovarian cancer. However, further studies are required to be conducted in vivo for its confirmation. JF - Indian journal of experimental biology AU - Roy, Subhadra AU - Ghosh, Sonali AU - Mallick, Palash AU - Maity, Putul AD - Department of Metabolic Regulation, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 22 EP - 26 VL - 46 IS - 1 SN - 0019-5189, 0019-5189 KW - Antimetabolites, Antineoplastic KW - 0 KW - Drug Combinations KW - Isoxazoles KW - Laminin KW - Proteoglycans KW - Tetrazolium Salts KW - Thiazoles KW - Vascular Endothelial Growth Factor A KW - Glutamine KW - 0RH81L854J KW - matrigel KW - 119978-18-6 KW - Collagen KW - 9007-34-5 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Glutaminase KW - EC 3.5.1.2 KW - thiazolyl blue KW - EUY85H477I KW - acivicin KW - O0X60K76I6 KW - Index Medicus KW - Neoplasm Invasiveness KW - Humans KW - Cell Line, Tumor KW - Cell Proliferation KW - Collagen -- chemistry KW - Tetrazolium Salts -- pharmacology KW - Thiazoles -- pharmacology KW - Laminin -- chemistry KW - Matrix Metalloproteinase 9 -- metabolism KW - In Vitro Techniques KW - Glutamine -- chemistry KW - Female KW - Proteoglycans -- chemistry KW - Vascular Endothelial Growth Factor A -- metabolism KW - Ovarian Neoplasms -- metabolism KW - Glutaminase -- metabolism KW - Breast Neoplasms -- metabolism KW - Antimetabolites, Antineoplastic -- chemistry KW - Isoxazoles -- therapeutic use KW - Isoxazoles -- chemistry KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69420061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+experimental+biology&rft.atitle=Acivicin+with+glutaminase+regulates+proliferation+and+invasion+of+human+MCF-7+and+OAW-42+cells--an+in+vitro+study.&rft.au=Roy%2C+Subhadra%3BGhosh%2C+Sonali%3BMallick%2C+Palash%3BMaity%2C+Putul&rft.aulast=Roy&rft.aufirst=Subhadra&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+experimental+biology&rft.issn=00195189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-03 N1 - Date created - 2008-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selected resources for emergency and disaster preparedness and response from the United States National Library of Medicine. AN - 69408298; 18689200 AB - The Toxicology and Environmental Health Information Program (TEHIP) of the National Library of Medicine (NLM) works to organize and provide access to a wide range of environmental health and toxicology resources. In recent years, the demand for, and availability of, information on health issues related to natural and man-made emergencies and disasters has increased. Recognizing that access to information is essential in disaster preparedness, a new focus of NLM's 2006-2016 Long Range Plan calls for the establishment of a Disaster Information Management Research Center (DIMRC) that will aid in collecting, disseminating, and sharing information related to health and disasters. This paper introduces several of TEHIP's resources for emergency/disaster preparedness and response, such as the Radiation Event Medical Management Web site (REMM) and the Wireless Information System for Emergency Responders (WISER) . Several of NLM's other disaster preparedness and response resources will also be reviewed. JF - Medical reference services quarterly AU - Hochstein, Colette AU - Arnesen, Stacey AU - Goshorn, Jeanne AU - Szczur, Marti AD - Division of Specialized Information Services (SIS), National Library of Medicine (NLM), 6707 Democracy Boulevard, Bethesda, MD 20892, USA. colette@nlm.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1 EP - 20 VL - 27 IS - 1 SN - 0276-3869, 0276-3869 KW - Health administration KW - United States KW - Terrorism KW - National Library of Medicine (U.S.) KW - Access to Information KW - Databases as Topic KW - Emergencies KW - Disaster Planning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69408298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+reference+services+quarterly&rft.atitle=Selected+resources+for+emergency+and+disaster+preparedness+and+response+from+the+United+States+National+Library+of+Medicine.&rft.au=Hochstein%2C+Colette%3BArnesen%2C+Stacey%3BGoshorn%2C+Jeanne%3BSzczur%2C+Marti&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2008-01-01&rft.volume=27&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Medical+reference+services+quarterly&rft.issn=02763869&rft_id=info:doi/10.1300%2FJ115v27n01_01 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-30 N1 - Date created - 2008-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Libr Assoc. 2007 Jul;95(3):316-22 [17641767] Med Ref Serv Q. 2006 Fall;25(3):13-31 [16893844] Med Ref Serv Q. 2007 Fall;26(3):21-45 [17915629] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1300/J115v27n01_01 ER - TY - JOUR T1 - Autologous stem cell transplantation with selected CD34+ cells and unmanipulated peripheral blood stem cells in patients with relapsed and refractory Hodgkin's lymphoma: a single centre experience. AN - 69371748; 18665754 AB - With the aim to evaluate the long term outcome after high-dose chemotherapy and autologous stem cell transplantation (HDCT+ASCT) in patients with relapsed or refractory Hodgkin's lymphoma (HL) we performed a retrospective analysis of patients transplanted at our centre. Between January 1993 and December 2005, 126 consecutive patients with relapsed or refractory HL in the age of 16 to 65 years underwent HDCT+ASCT at our centre and were enrolled in this retrospective analysis. Patients were autografted with either CD34+ positively selected or unmanipulated periferal blood stem cells (PBSC). With a median follow up of 69 months (3-162 months), the actuarial 5-y PFS and OS for all patients after HDCT+ASCT were 59% and 72%, respectively. In patients transplanted from 1996 the actuarial 5-y PFS and OS for CD34+ selected group were 64% and 79% and for unmanipulated PBSC group 63% and 66%, respectively. A total of 42/126 (33%) patients died. Treatment related mortality (TRM) was 3% (4 patients). In univariate analysis, chemosensitive disease and increased LDH were the strongest prognostic factors for PFS and OS. Our results confirm the efficacy of HDCT+ASCT in relapsed or refractory HL with acceptable toxicity. The use of CD34+ positively selected stem cells for autografting is feasible, safe and effective procedure. JF - Neoplasma AU - Ballova, V AU - Ladicka, M AU - Vranovsky, A AU - Lakota, J AD - Department of Internal Medicine, National Cancer Institute, Bratislava, Slovakia. Y1 - 2008 PY - 2008 DA - 2008 SP - 428 EP - 436 VL - 55 IS - 5 SN - 0028-2685, 0028-2685 KW - Antigens, CD34 KW - 0 KW - Index Medicus KW - Transplantation Conditioning KW - Combined Modality Therapy KW - Humans KW - Hematopoietic Stem Cell Mobilization KW - Salvage Therapy KW - Retrospective Studies KW - Transplantation, Autologous KW - Adult KW - Middle Aged KW - Adolescent KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Female KW - Male KW - Survival Analysis KW - Stem Cell Transplantation -- methods KW - Peripheral Blood Stem Cell Transplantation -- methods KW - Hodgkin Disease -- therapy KW - Antigens, CD34 -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69371748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasma&rft.atitle=Autologous+stem+cell+transplantation+with+selected+CD34%2B+cells+and+unmanipulated+peripheral+blood+stem+cells+in+patients+with+relapsed+and+refractory+Hodgkin%27s+lymphoma%3A+a+single+centre+experience.&rft.au=Ballova%2C+V%3BLadicka%2C+M%3BVranovsky%2C+A%3BLakota%2C+J&rft.aulast=Ballova&rft.aufirst=V&rft.date=2008-01-01&rft.volume=55&rft.issue=5&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Neoplasma&rft.issn=00282685&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-09 N1 - Date created - 2008-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. AN - 69357422; 18632220 AB - Previous studies have shown important effects of stromal elements in carcinogenesis. To explore the tumor-stromal relationship in esophageal neoplasia, we examined methylation of COX-2 (PTGS2), a gene etiologically associated with the development of gastrointestinal cancers, in adjacent foci of epithelium, subepithelial lymphocytes and non-lymphocytic stromal cells found in sections of normal squamous epithelium, squamous dysplasia and invasive esophageal squamous cell carcinoma. Adjacent foci of epithelium, subepithelial lymphocytic aggregates and non-lymphocytic stromal tissues were laser microdissected from six fully embedded, ethanol fixed, esophagectomy samples from Shanxi, China, a high-risk region for esophageal cancer. Promoter CpG site-specific hypermethylation status of COX-2 was determined using real-time methylation-specific PCR (qMS-PCR) based on Taqman Chemistry. The methylation status of a subset of samples was confirmed by pyrosequencing. Forty-nine microdissected foci were analyzed. COX-2 gene methylation was significantly more common in subepithelial lymphocytes (12/16 (75% of all foci)) than in epithelial foci (3/16 (19%)) or foci of non-lymphocytic stromal tissues (3/17 (18%)) (Fisher's exact p=0.05). Two of three epithelial samples and all three stromal samples that showed COX-2 methylation were adjacent to foci of methylated subepithelial lymphocytes. Pyrosequencing confirmed the methylation status in a subset of samples. In these esophageal cancer patients, COX-2 gene methylation was more common in subepithelial lymphocytes than in adjacent epithelial or stromal cells in both grades of dysplasia and in foci of invasive cancer. These findings raise the possibility that methylation of subepithelial lymphocytes may be important for tumorigenesis. Future studies of gene methylation should consider separate evaluation of epithelial and non-epithelial cell populations. JF - Cancer detection and prevention AU - Dawsey, Sonja P AU - Roth, Mark J AU - Adams, Lisa AU - Hu, Nan AU - Wang, Quan-Hong AU - Taylor, Philip R AU - Woodson, Karen AD - Cancer Genetics Branch, Center for Cancer Research, National Cancer Institute, Rockville, MD 20892, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 135 EP - 139 VL - 32 IS - 2 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Index Medicus KW - Microdissection KW - DNA Methylation KW - Humans KW - Reverse Transcriptase Polymerase Chain Reaction KW - Epithelial Cells -- physiology KW - Cyclooxygenase 2 -- genetics KW - Carcinoma, Squamous Cell -- pathology KW - Stromal Cells -- physiology KW - Esophageal Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Lymphocytes -- physiology KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69357422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+detection+and+prevention&rft.atitle=COX-2+%28PTGS2%29+gene+methylation+in+epithelial%2C+subepithelial+lymphocyte+and+stromal+tissue+compartments+in+a+spectrum+of+esophageal+squamous+neoplasia.&rft.au=Dawsey%2C+Sonja+P%3BRoth%2C+Mark+J%3BAdams%2C+Lisa%3BHu%2C+Nan%3BWang%2C+Quan-Hong%3BTaylor%2C+Philip+R%3BWoodson%2C+Karen&rft.aulast=Dawsey&rft.aufirst=Sonja&rft.date=2008-01-01&rft.volume=32&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Cancer+detection+and+prevention&rft.issn=1525-1500&rft_id=info:doi/10.1016%2Fj.cdp.2008.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-09 N1 - Date created - 2008-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 2000 May 15;86(4):553-60 [10797271] J Pathol. 2007 Mar;211(4):410-9 [17278115] Immunol Res. 2000;22(2-3):319-41 [11339365] Int J Cancer. 2002 Jan 20;97(3):272-7 [11774276] Int J Cancer. 2002 Nov 20;102(3):271-4 [12397650] Clin Cancer Res. 2003 Mar;9(3):961-8 [12631593] Nat Rev Cancer. 2003 Apr;3(4):253-66 [12671664] Prostate. 2003 May 15;55(3):199-205 [12692786] Biotechniques. 2003 Jul;35(1):146-50 [12866414] Biotechniques. 2003 Jul;35(1):152-6 [12866415] Cancer Res. 2003 Nov 15;63(22):7845-52 [14633712] Prostate. 2004 Jun 15;60(1):25-31 [15129426] Br J Cancer. 2004 Jun 1;90(11):2157-66 [15150609] Cancer. 1994 Apr 15;73(8):2027-37 [8156507] Prog Growth Factor Res. 1994;5(2):223-48 [7919226] Science. 1996 Nov 8;274(5289):998-1001 [8875945] Cancer Res. 1998 Jan 15;58(2):362-6 [9443418] Gastroenterology. 2004 Nov;127(5):1578-88 [15521024] Tumour Biol. 2005 Jul-Aug;26(4):173-85 [16006771] Crit Rev Oncol Hematol. 2005 Oct;56(1):5-22 [15978831] Anticancer Res. 2005 Nov-Dec;25(6A):3679-87 [16302726] Mol Biol (Mosk). 2007 Jan-Feb;41(1):79-85 [17380894] Cancer Res. 2001 Feb 15;61(4):1320-6 [11245428] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cdp.2008.05.001 ER - TY - JOUR T1 - Autologous stem cell transplantation in first-line treatment of high-risk aggressive non-Hodgkin's lymphoma. AN - 69346286; 18652043 AB - A single center, retrospective analysis evaluating the outcome of patients with poor-risk aggressive non-Hodgkin's lymphoma (NHL) treated with high-dose chemotherapy and autologous stem cell transplantation (ASCT) as a part of firstline therapy. Forty-seven patients younger than 65 years with diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), peripheral T-cell lymphoma (PTCL) or alk-negative anaplastic large cell lymphoma (ALCL) underwent ASCT between July 1997 and November 2005. Patients with DLBCL and alk-negative ALCL had 2 or 3 age-adjusted International Prognostic Index risk factors. All patients were transplanted after MACOP-B induction therapy followed by 2 courses of DHAP and myeloablative chemotherapy BEM or CBV. The complete response rate to the high-dose therapy was 79% with an estimated 5-year progression-free survival of 66%. At a median follow-up of 35 months (range, 16 to 112 months) the estimated overall survival at five years was 59%. There were 4 treatment-related deaths. Twenty-nine of 47 patients remain in complete remission. Our results confirm the efficacy of high-dose therapy with ASCT during first-line treatment of patients with poor-prognosis aggressive lymphoma, with substantial number of patients cured by using this treatment approach. JF - Neoplasma AU - Vranovsky, A AU - Ladicka, M AU - Lakota, J AD - National Cancer Institute, Bratislava, Slovakia. Y1 - 2008 PY - 2008 DA - 2008 SP - 107 EP - 112 VL - 55 IS - 2 SN - 0028-2685, 0028-2685 KW - Cytarabine KW - 04079A1RDZ KW - Bleomycin KW - 11056-06-7 KW - Vincristine KW - 5J49Q6B70F KW - Dexamethasone KW - 7S5I7G3JQL KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisolone KW - 9PHQ9Y1OLM KW - Cisplatin KW - Q20Q21Q62J KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Dexamethasone -- therapeutic use KW - Combined Modality Therapy KW - Humans KW - Retrospective Studies KW - Transplantation, Autologous KW - Prednisolone -- therapeutic use KW - Cisplatin -- therapeutic use KW - Cytarabine -- therapeutic use KW - Cyclophosphamide -- therapeutic use KW - Vincristine -- therapeutic use KW - Adult KW - Methotrexate -- therapeutic use KW - Middle Aged KW - Doxorubicin -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Bleomycin -- therapeutic use KW - Female KW - Male KW - Lymphoma, Non-Hodgkin -- mortality KW - Lymphoma, Non-Hodgkin -- therapy KW - Hematopoietic Stem Cell Transplantation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69346286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasma&rft.atitle=Autologous+stem+cell+transplantation+in+first-line+treatment+of+high-risk+aggressive+non-Hodgkin%27s+lymphoma.&rft.au=Vranovsky%2C+A%3BLadicka%2C+M%3BLakota%2C+J&rft.aulast=Vranovsky&rft.aufirst=A&rft.date=2008-01-01&rft.volume=55&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Neoplasma&rft.issn=00282685&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-05 N1 - Date created - 2008-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The RAD5-dependent postreplication repair pathway is important to suppress gross chromosomal rearrangements. AN - 69338630; 18647995 AB - Genome instability is characteristic of cancer cells. Although it frequently occurs during carcinogenesis, the mechanism underlying genome instability is not clearly understood. Recent extensive genetic analyses from different organisms have begun to reveal mechanisms for the suppression of genome instability in general DNA metabolisms including DNA replication, recombination, DNA repair, and signal transduction. One DNA repair pathway called postreplication repair (also known as DNA damage bypass) has been highlighted for its role in genome stability. Central to DNA damage bypass, proliferating cell nuclear antigen (PCNA) directs different pathways through its mono- or polyubiquitination and sumoylation. In this review, we will discuss template switching dictated by the PCNA polyubiquitination and its roles in the suppression of genome instabilities. JF - Journal of the National Cancer Institute. Monographs AU - Myung, Kyungjae AU - Smith, Stephanie AD - Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Building 49, Room 4A22, Bethesda, MD 20892, USA. kmyung@nhgri.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 12 EP - 15 IS - 39 SN - 1052-6773, 1052-6773 KW - Proliferating Cell Nuclear Antigen KW - 0 KW - Saccharomyces cerevisiae Proteins KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - RAD5 protein, S cerevisiae KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - DNA Damage KW - Proliferating Cell Nuclear Antigen -- metabolism KW - DNA Replication KW - Saccharomyces cerevisiae -- genetics KW - DNA Repair KW - Genes, Fungal -- physiology KW - Saccharomyces cerevisiae Proteins -- genetics KW - Gene Rearrangement KW - Adenosine Triphosphatases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69338630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute.+Monographs&rft.atitle=The+RAD5-dependent+postreplication+repair+pathway+is+important+to+suppress+gross+chromosomal+rearrangements.&rft.au=Myung%2C+Kyungjae%3BSmith%2C+Stephanie&rft.aulast=Myung&rft.aufirst=Kyungjae&rft.date=2008-01-01&rft.volume=&rft.issue=39&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute.+Monographs&rft.issn=10526773&rft_id=info:doi/10.1093%2Fjncimonographs%2Flgn019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-07-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1994 Nov 11;269(45):28259-62 [7961763] Mol Cell Biol. 1992 Sep;12(9):3807-18 [1324406] Biochim Biophys Acta. 1998 Oct 1;1400(1-3):107-19 [9748525] EMBO J. 1998 Nov 16;17(22):6427-36 [9822589] Semin Cancer Biol. 2005 Feb;15(1):1 [15613282] Mol Cell. 2005 Jul 1;19(1):123-33 [15989970] Nature. 2005 Jul 21;436(7049):428-33 [15931174] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15954-9 [16247017] Mol Cell. 2006 Jan 6;21(1):15-27 [16387650] Mol Cell Biol. 2006 Feb;26(4):1424-33 [16449653] Nat Cell Biol. 2006 Apr;8(4):339-47 [16531995] PLoS Genet. 2006 Jul;2(7):e116 [16789823] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18107-12 [17108083] J Cell Biol. 2006 Dec 4;175(5):703-8 [17130289] Cell. 2007 May 18;129(4):665-79 [17512402] Science. 2007 May 25;316(5828):1138-9 [17525326] Cell. 2000 Jan 7;100(1):57-70 [10647931] Nat Genet. 2001 Mar;27(3):247-54 [11242102] Science. 2002 Jul 26;297(5581):552-7 [12142524] Nature. 2002 Sep 12;419(6903):135-41 [12226657] DNA Repair (Amst). 2003 Mar 1;2(3):243-58 [12547388] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):776-81 [12552134] Genomics. 2003 Aug;82(2):153-61 [12837266] Curr Opin Cell Biol. 2004 Apr;16(2):119-26 [15196553] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9039-44 [15184655] Mutat Res. 1998 Mar;407(2):135-45 [9637242] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jncimonographs/lgn019 ER - TY - JOUR T1 - Chromosomal aberrations in peripheral blood lymphocytes and risk for non-Hodgkin lymphoma. AN - 69337562; 18648009 AB - Chromosomal aberrations (CAs) are thought to be integrative biomarkers that reflect exposure to chromosome-damaging carcinogens and host factors. To investigate whether CAs indicate non-Hodgkin lymphoma (NHL) risk, we evaluated 200 metaphase spreads each for 67 incident low-grade, untreated NHL cases and 57 controls matched on age, sex, and storage time of cryopreserved lymphocytes. Hyperdiploidy of 47 chromosomes was statistically significantly associated with increased NHL risk with odds ratios of 1.4 (97% confidence interval [CI] = 0.6-3.5) and 3.5 (95% CI = 1.1-10.9) for medium and high levels of hyperdiploidy, respectively, compared to the lowest level (P-trend = .04). Hypodiploidy of 43 and 44 chromosomes increased NHL risk 3.3-fold (95% CI = 1.2-8.7) and 2.2 (95% CI = 1.0-5.2), respectively, compared to those without the event; total hypodiploidy was only moderately associated with risk. Chromosome and chromatid breaks were not associated with NHL risk. Our data suggest for the first time that aneuploidy identified in cultured, peripheral lymphocytes may be potential indicators of NHL risk. JF - Journal of the National Cancer Institute. Monographs AU - Wang, Sophia S AU - Davis, Scott AU - Hartge, Patricia AU - Cozen, Wendy AU - Severson, Richard K AU - Cerhan, James R AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS MSC #7234, Bethesda, MD 20892-7234, USA. wangso@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 78 EP - 82 IS - 39 SN - 1052-6773, 1052-6773 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Ploidies KW - Male KW - Female KW - Leukemia, Lymphocytic, Chronic, B-Cell -- genetics KW - Lymphoma, Large B-Cell, Diffuse -- epidemiology KW - Lymphoma, Follicular -- genetics KW - Leukemia, Lymphocytic, Chronic, B-Cell -- epidemiology KW - Lymphoma, B-Cell -- epidemiology KW - Chromosome Aberrations KW - Lymphocytes -- metabolism KW - Lymphocytes -- cytology KW - Lymphoma, B-Cell -- genetics KW - Lymphoma, Large B-Cell, Diffuse -- genetics KW - Lymphoma, Follicular -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69337562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute.+Monographs&rft.atitle=Chromosomal+aberrations+in+peripheral+blood+lymphocytes+and+risk+for+non-Hodgkin+lymphoma.&rft.au=Wang%2C+Sophia+S%3BDavis%2C+Scott%3BHartge%2C+Patricia%3BCozen%2C+Wendy%3BSeverson%2C+Richard+K%3BCerhan%2C+James+R%3BRothman%2C+Nathaniel&rft.aulast=Wang&rft.aufirst=Sophia&rft.date=2008-01-01&rft.volume=&rft.issue=39&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute.+Monographs&rft.issn=10526773&rft_id=info:doi/10.1093%2Fjncimonographs%2Flgn016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jncimonographs/lgn016 ER - TY - JOUR T1 - Transgenic rodent models of Parkinson's disease. AN - 69331900; 18642640 AB - In the case of Parkinson's disease (PD), classical animal models have utilized dopaminergic neurotoxins such as 6-hydroxydopamine (6OHDA) and 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP). More recently, human genetic linkage studies have identified several genes in familial forms of PD. Transgenic models have been made that explore the function of PD-linked genes (e.g. alpha-synuclein, DJ-1, LRRK2, Parkin, UCH-L1, PINK1). Recent evidence suggests mitochondrial dysfunction may play a major role in PD. Manipulation of mitochondrial respiratory genes (e.g. mitochondrial transcription factor A or TFAM) also elicits a PD phenotype in mice. Transgenic mice (MitoPark) were developed that have TFAM selectively knocked out in dopaminergic neurons. The nigral dopamine neurons of MitoPark mice show respiratory chain dysfunction, accompanied by the development of intraneuronal inclusions and eventual cell death. In early adulthood, the MitoPark mice show a slowly progressing loss of motor function that accompanies these cellular changes. The MitoPark mouse enables further study of the role of mitochondrial dysfunction in DA neurons as an important mechanism in the development of PD. Transgenic technology has allowed new insights into mechanisms of neurodegeneration for a number of neurological disorders. This paper will summarize recent studies on several transgenic models of PD. JF - Acta neurochirurgica. Supplement AU - Harvey, B K AU - Wang, Y AU - Hoffer, B J AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore 21224, MD, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 89 EP - 92 VL - 101 SN - 0065-1419, 0065-1419 KW - DNA-Binding Proteins KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - Mitochondrial Proteins KW - Oncogene Proteins KW - Transcription Factors KW - mitochondrial transcription factor A KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - parkin protein KW - Protein Kinases KW - EC 2.7.- KW - PTEN-induced putative kinase KW - EC 2.7.11.1 KW - PARK7 protein, human KW - EC 3.1.2.- KW - Protein Deglycase DJ-1 KW - Index Medicus KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Animals KW - Humans KW - Ubiquitin-Protein Ligases -- genetics KW - Protein Kinases -- genetics KW - DNA-Binding Proteins -- genetics KW - Oncogene Proteins -- genetics KW - Mitochondrial Proteins -- genetics KW - Mice KW - Transcription Factors -- genetics KW - Mutation KW - Parkinson Disease -- etiology KW - Disease Models, Animal KW - Parkinson Disease -- genetics KW - Mice, Transgenic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69331900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+neurochirurgica.+Supplement&rft.atitle=Transgenic+rodent+models+of+Parkinson%27s+disease.&rft.au=Harvey%2C+B+K%3BWang%2C+Y%3BHoffer%2C+B+J&rft.aulast=Harvey&rft.aufirst=B&rft.date=2008-01-01&rft.volume=101&rft.issue=&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Acta+neurochirurgica.+Supplement&rft.issn=00651419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2008-07-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 2006 May;38(5):515-7 [16604074] Neurology. 2005 Jul 12;65(1):87-95 [16009891] Nature. 2006 Jun 29;441(7097):1162-6 [16672981] Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30 [17227870] Ann Neurol. 2005 Nov;58(5):803-7 [16240358] Nat Med. 2001 Oct;7(10):1144-50 [11590439] Science. 2003 Jan 10;299(5604):256-9 [12446870] Ann Neurol. 2003 Aug;54(2):271-4 [12891685] Ann Neurol. 2003 Sep;54(3):283-6 [12953260] Neuron. 2003 Sep 11;39(6):889-909 [12971891] J Biol Chem. 2003 Oct 31;278(44):43628-35 [12930822] Ann Neurol. 2004 Sep;56(3):424-7 [15349870] Hum Mol Genet. 1999 Apr;8(4):567-74 [10072423] Neuron. 2005 Feb 17;45(4):489-96 [15721235] J Biol Chem. 2005 Jun 3;280(22):21418-26 [15799973] Brain. 2006 Jul;129(Pt 7):1720-31 [16702191] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? AN - 69296057; 18612013 AB - New clinical and basic science data on the cellular and molecular mechanisms by which wear particles stimulate the host inflammatory response have provided deeper insight into the pathophysiology of periprosthetic bone loss. Interactions among wear particles, macrophages, osteoblasts, bone marrow-derived mesenchymal stem cells, fibroblasts, endothelial cells, and T cells contribute to the production of pro-inflammatory and pro-osteoclastogenic cytokines such as TNF-alpha, RANKL, M-SCF, PGE2, IL-1, IL-6, and IL-8. These cytokines not only promote osteoclastogenesis but interfere with osteogenesis led by osteoprogenitor cells. Recent studies indicate that genetic variations in TNF-alpha, IL-1, and FRZB can result in subtle changes in gene function, giving rise to altered susceptibility or severity for periprosthetic inflammation and bone loss. Continuing research on the biologic effects and mechanisms of action of wear particles will provide a rational basis for the development of novel and effective ways of diagnosis, prevention, and treatment of periprosthetic inflammatory bone loss. JF - The Journal of the American Academy of Orthopaedic Surgeons AU - Tuan, Rocky S AU - Lee, Francis Young-In AU - T Konttinen, Yrjö AU - Wilkinson, J Mark AU - Smith, Robert Lane AU - Implant Wear Symposium 2007 Biologic Work Group AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA. ; Implant Wear Symposium 2007 Biologic Work Group Y1 - 2008 PY - 2008 DA - 2008 SP - S42 EP - S48 VL - 16 Suppl 1 SN - 1067-151X, 1067-151X KW - Basic Helix-Loop-Helix Transcription Factors KW - 0 KW - Biocompatible Materials KW - Interleukin-1 KW - Interleukin-6 KW - Interleukin-8 KW - MSC protein, human KW - RANK Ligand KW - TNFSF11 protein, human KW - Tumor Necrosis Factor-alpha KW - Macrophage Colony-Stimulating Factor KW - 81627-83-0 KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Humans KW - Interleukin-6 -- metabolism KW - RANK Ligand -- metabolism KW - Endothelial Cells -- immunology KW - Macrophage Colony-Stimulating Factor -- metabolism KW - Fibroblasts -- immunology KW - Stem Cells -- immunology KW - Interleukin-1 -- metabolism KW - Dinoprostone -- metabolism KW - Osteogenesis -- immunology KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Osteoclasts -- immunology KW - Tumor Necrosis Factor-alpha -- metabolism KW - Interleukin-8 -- metabolism KW - T-Lymphocytes -- immunology KW - Prosthesis Failure KW - Foreign-Body Reaction -- immunology KW - Biocompatible Materials -- adverse effects KW - Bone Resorption -- immunology KW - Joint Prosthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69296057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+American+Academy+of+Orthopaedic+Surgeons&rft.atitle=What+are+the+local+and+systemic+biologic+reactions+and+mediators+to+wear+debris%2C+and+what+host+factors+determine+or+modulate+the+biologic+response+to+wear+particles%3F&rft.au=Tuan%2C+Rocky+S%3BLee%2C+Francis+Young-In%3BT+Konttinen%2C+Yrj%C3%B6%3BWilkinson%2C+J+Mark%3BSmith%2C+Robert+Lane%3BImplant+Wear+Symposium+2007+Biologic+Work+Group&rft.aulast=Tuan&rft.aufirst=Rocky&rft.date=2008-01-01&rft.volume=16+Suppl+1&rft.issue=&rft.spage=S42&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+American+Academy+of+Orthopaedic+Surgeons&rft.issn=1067151X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-26 N1 - Date created - 2008-07-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bone Miner Res. 2001 Feb;16(2):338-47 [11204434] J Orthop Res. 2000 Sep;18(5):800-7 [11117303] J Biomed Mater Res. 2001 Oct;57(1):84-91 [11416853] J Orthop Res. 2001 Sep;19(5):970-6 [11562149] J Bone Joint Surg Am. 2001 Dec;83-A(12):1789-97 [11741056] J Orthop Res. 2002 Sep;20(5):1060-9 [12382974] J Orthop Res. 2002 Nov;20(6):1175-84 [12472226] J Orthop Res. 2003 Mar;21(2):202-12 [12568950] Arthritis Res Ther. 2003;5(1):32-45 [12716446] Biomaterials. 2003 Jul;24(15):2561-73 [12726710] J Biomed Mater Res A. 2003 May 1;65(2):290-8 [12734824] J Orthop Res. 2003 Jul;21(4):697-707 [12798071] J Bone Miner Res. 2003 Sep;18(9):1573-83 [12968666] Stem Cells. 2003;21(6):681-93 [14595128] J Bone Miner Res. 2003 Nov;18(11):1995-2001 [14606512] Biomaterials. 2004 Aug;25(17):3511-22 [15020125] J Bone Miner Metab. 2004;22(4):346-51 [15221493] Tissue Eng. 2004 Jul-Aug;10(7-8):1169-79 [15363173] J Bone Joint Surg Am. 1976 Jul;58(5):612-8 [932060] Arthritis Rheum. 1986 Jul;29(7):836-42 [3091038] Acta Orthop Scand. 1992 Apr;63(2):225-32 [1590066] J Biomed Mater Res. 1995 Jan;29(1):127-31 [7713952] J Bone Joint Surg Am. 1995 Sep;77(9):1301-10 [7673277] Clin Orthop Relat Res. 1996 Jan;(322):158-65 [8542692] J Biomed Mater Res. 1996 Jul;31(3):421-8 [8806069] Arch Orthop Trauma Surg. 1996;115(5):286-9 [8836463] J Bone Joint Surg Am. 1997 Jan;79(1):107-12 [9010191] Clin Rheumatol. 1997 May;16(3):243-8 [9184260] Clin Orthop Relat Res. 1998 Jul;(352):7-15 [9678028] Biomaterials. 1998 Dec;19(24):2297-302 [9884043] J Bone Joint Surg Br. 1999 Jan;81(1):155-62 [10068024] J Biomed Mater Res. 1999 Sep 5;46(3):399-407 [10397998] Biomaterials. 2005 May;26(15):2371-9 [15585240] J Arthroplasty. 2004 Dec;19(8):1028-38 [15586339] Clin Orthop Relat Res. 2005 Jan;(430):28-38 [15662301] Clin Orthop Relat Res. 2005 Jan;(430):39-45 [15662302] J Rheumatol. 2005 Apr;32(4):713-20 [15801030] J Orthop Res. 2005 May;23(3):501-10 [15885468] J Biomed Mater Res B Appl Biomater. 2005 Jul;74(1):582-8 [15768436] J Biomed Mater Res A. 2006 Apr;77(1):192-201 [16392133] J Orthop Res. 2006 Mar;24(3):461-73 [16450379] J Bone Joint Surg Br. 2006 Apr;88(4):449-54 [16567777] J Biomed Mater Res A. 2006 Jun 15;77(4):850-6 [16596588] Proc Inst Mech Eng H. 2006 Feb;220(2):355-69 [16669401] Nat Clin Pract Rheumatol. 2006 Jul;2(7):373-82 [16932723] Arthritis Rheum. 2006 Oct;54(10):3221-32 [17009257] J Orthop Res. 2007 Apr;25(4):450-7 [17205559] J Bone Joint Surg Am. 2007 Apr;89(4):841-8 [17403809] J Bone Joint Surg Am. 2007 May;89(5):1081-9 [17473147] J Orthop Res. 2007 Dec;25(12):1665-70 [17600823] Ann N Y Acad Sci. 2007 Nov;1117:143-50 [18056040] Ann N Y Acad Sci. 2007 Nov;1117:151-8 [18056041] J Biomed Mater Res A. 2008 Feb;84(2):464-74 [17618502] J Biomed Mater Res. 2000 Sep 5;51(3):360-8 [10880077] J Biomed Mater Res. 2000 Sep;53(5):490-7 [10984696] Biorheology. 2001;38(2-3):161-83 [11381173] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exercise stress testing in recently abstinent chronic cocaine abusers. AN - 69261552; 18584578 AB - We compared treadmill exercise stress testing (EST) in 28 medically screened, chronic cocaine users with the cardiovascular effects of an IV cocaine challenge (25 mg or 50 mg). All subjects had a clinically normal EST and echocardiography (except 2 subjects had septal wall hypokinesis). The EST produced significantly greater increases in heart rate and rate-pressure product than did the cocaine challenges. These findings suggest that EST may not provide additional diagnostic information in medically screened cocaine users. EST may cause more cardiac work (indicated by heart rate and blood pressure) than intravenous cocaine (at the doses in this study). JF - The American journal of drug and alcohol abuse AU - Kanneganti, Praveen AU - Nelson, Richard A AU - Boyd, Susan J AU - Ziegelstein, Roy C AU - Gorelick, David A AD - Department of Health and Human Services, Office of the Science Director, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224-2816, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 489 EP - 498 VL - 34 IS - 4 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Echocardiography KW - Adult KW - Chronic Disease KW - Male KW - Female KW - Exercise Test KW - Heart Rate -- drug effects KW - Patient Compliance KW - Cardiovascular Diseases -- epidemiology KW - Substance Abuse, Intravenous -- rehabilitation KW - Cardiovascular Diseases -- chemically induced KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects KW - Cocaine -- administration & dosage KW - Cardiovascular Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69261552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Exercise+stress+testing+in+recently+abstinent+chronic+cocaine+abusers.&rft.au=Kanneganti%2C+Praveen%3BNelson%2C+Richard+A%3BBoyd%2C+Susan+J%3BZiegelstein%2C+Roy+C%3BGorelick%2C+David+A&rft.aulast=Kanneganti&rft.aufirst=Praveen&rft.date=2008-01-01&rft.volume=34&rft.issue=4&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=1097-9891&rft_id=info:doi/10.1080%2F00952990802082214 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-14 N1 - Date created - 2008-06-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2001 Aug 2;345(5):351-8 [11484693] Drug Alcohol Depend. 2006 Mar 15;82(1):19-24 [16144747] J Forensic Sci. 1978 Jan;23(1):173-89 [744960] Ann Intern Med. 1989 Dec 1;111(11):876-80 [2817640] Am J Med. 1990 Apr;88(4):325-31 [2327419] Am J Forensic Med Pathol. 1991 Jun;12(2):126-31 [1812853] J Addict Dis. 1991;10(4):47-65 [1777499] Circulation. 1992 Jul;86(1):226-31 [1535569] J Am Coll Cardiol. 1993 Nov 15;22(6):1581-6 [8227824] Chest. 1995 May;107(5):1426-34 [7750342] Chest. 1997 Oct;112(4):1008-16 [9377910] J Forensic Sci. 1998 Jan;43(1):41-5 [9456523] Pediatrics. 1963 Oct;32:SUPPL 742-56 [14070531] J Emerg Med. 2005 Aug;29(2):173-8 [16029829] Postgrad Med J. 2005 Sep;81(959):568-71 [16143686] Emerg Med Clin North Am. 2005 Nov;23(4):1083-103 [16199339] Heart Dis. 2003 Jul-Aug;5(4):253-71 [12877759] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/00952990802082214 ER - TY - JOUR T1 - Dietary cooked navy beans and their fractions attenuate colon carcinogenesis in azoxymethane-induced ob/ob mice. AN - 69151156; 18444172 AB - Based on the protective effects of cooked dry bean consumption in a human intervention study, we evaluated which fraction of cooked dry beans is responsible for its cancer-preventive effects. Cooked navy beans (whole beans), the insoluble fraction (bean residue) or soluble fraction of the 60% (vol:vol) ethanol extract of cooked navy beans (bean extract), or a modified AIN-93G diet (16.6% fat including 12.9% lard) as control diet were fed to 160 male obese ob/ob mice after 2 azoxymethane injections. In comparison to control-fed mice, dysplasia, adenomas, or adenocarcinomas were detected in fewer mice on either bean fraction diet (percent reduction from control: whole beans 54%, P=0.10; bean residue 81%, P=0.003; bean extract 91%, P=0.007), and any type of colon lesions, including focal hyperplasia, were found in fewer mice on each of the 3 bean diets percent reduction from control: whole bean 56%, P=0.04; bean residue 67%, P=0.01; bean extract 87%, P=0.0003. These results suggest that both the soluble and the insoluble fraction of the extract contribute to the cancer-protective effect of cooked navy beans. JF - Nutrition and cancer AU - Bobe, Gerd AU - Barrett, Kathleen G AU - Mentor-Marcel, Roycelynn A AU - Saffiotti, Umberto AU - Young, Matthew R AU - Colburn, Nancy H AU - Albert, Paul S AU - Bennink, Maurice R AU - Lanza, Elaine AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA. bobeg@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 373 EP - 381 VL - 60 IS - 3 SN - 0163-5581, 0163-5581 KW - Anticarcinogenic Agents KW - 0 KW - Carcinogens KW - Plant Extracts KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Solubility KW - Mice, Obese KW - Adenocarcinoma -- chemically induced KW - Random Allocation KW - Adenoma -- prevention & control KW - Adenoma -- chemically induced KW - Carcinogens -- toxicity KW - Mice KW - Adenocarcinoma -- prevention & control KW - Male KW - Carcinogens -- antagonists & inhibitors KW - Plant Extracts -- pharmacology KW - Anticarcinogenic Agents -- analysis KW - Azoxymethane -- toxicity KW - Azoxymethane -- antagonists & inhibitors KW - Anticarcinogenic Agents -- pharmacology KW - Colonic Neoplasms -- prevention & control KW - Colonic Neoplasms -- chemically induced KW - Plant Extracts -- analysis KW - Fabaceae -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69151156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+and+cancer&rft.atitle=Dietary+cooked+navy+beans+and+their+fractions+attenuate+colon+carcinogenesis+in+azoxymethane-induced+ob%2Fob+mice.&rft.au=Bobe%2C+Gerd%3BBarrett%2C+Kathleen+G%3BMentor-Marcel%2C+Roycelynn+A%3BSaffiotti%2C+Umberto%3BYoung%2C+Matthew+R%3BColburn%2C+Nancy+H%3BAlbert%2C+Paul+S%3BBennink%2C+Maurice+R%3BLanza%2C+Elaine&rft.aulast=Bobe&rft.aufirst=Gerd&rft.date=2008-01-01&rft.volume=60&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Nutrition+and+cancer&rft.issn=01635581&rft_id=info:doi/10.1080%2F01635580701775142 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-10-20 N1 - Date created - 2008-04-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Cancer Prev. 1999 Dec;8 Suppl 1:S49-52 [10772418] Carcinogenesis. 2000 May;21(5):959-63 [10783318] Cancer Lett. 2000 Aug 31;157(1):15-21 [10893437] Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1271-9 [11142411] Adv Exp Med Biol. 2002;505:123-33 [12083456] Nutr Cancer. 2002;44(1):60-5 [12672642] J Nutr. 2003 Nov;133(11 Suppl 1):3778S-3784S [14608114] J Med Food. 2004 Spring;7(1):67-78 [15117556] Curr Med Chem Anticancer Agents. 2004 May;4(3):263-72 [15134504] Arch Latinoam Nutr. 2004 Mar;54(1):36-44 [15332354] J Nutr. 2004 Oct;134(10):2673-7 [15465765] Int J Cancer. 1993 Mar 12;53(5):711-9 [8449594] J Nutr. 1993 Nov;123(11):1939-51 [8229312] IARC Sci Publ. 1994;(111):195-221 [8082907] J Nutr. 1995 Mar;125(3 Suppl):717S-724S [7884557] Cancer Res. 1997 Jan 15;57(2):225-8 [9000559] Gastroenterology. 1997 Feb;112(2):594-642 [9024315] J Nutr. 1997 Dec;127(12):2328-33 [9405582] Am J Epidemiol. 1998 Oct 15;148(8):761-74 [9786231] Am J Med. 1999 Jan 25;106(1A):16S-19S; discussion 50S-51S [10089109] Am J Clin Nutr. 1999 Sep;70(3 Suppl):532S-538S [10479227] Anticancer Res. 2004 Sep-Oct;24(5A):3049-55 [15517915] Semin Oncol. 2005 Feb;32(1):24-34 [15726503] Br J Nutr. 2005 Apr;93 Suppl 1:S73-90 [15877900] J Agric Food Chem. 2005 Aug 24;53(17):6658-65 [16104781] Eur J Cancer. 2005 Sep;41(13):1911-22 [16084718] Cancer Res. 2006 Apr 1;66(7):3942-53 [16585224] J Nutr. 2006 Jul;136(7):1896-903 [16772456] J Agric Food Chem. 2006 Jul 26;54(15):5375-81 [16848520] Carcinogenesis. 2006 Sep;27(9):1849-59 [16597648] Int J Cancer. 2006 Nov 1;119(9):2213-20 [16823841] Cancer. 2006 Oct 1;107(7):1624-33 [16933324] J Nutr. 2007 Jan;137(1 Suppl):211S-215S [17182828] Cancer Res. 1981 Sep;41(9 Pt 2):3685-90 [6266659] Cancer Invest. 1984;2(3):223-31 [6733565] Int J Cancer. 1991 Sep 9;49(2):161-7 [1652565] Nutr Cancer. 1993;19(1):11-9 [8383315] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/01635580701775142 ER - TY - JOUR T1 - Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics. AN - 69140976; 18241344 AB - Whether cancer stem cells occur in BRCA1-associated breast cancer and contribute to therapeutic response is not known. We generated and characterized 16 cell lines from five distinct Brca1deficient mouse mammary tumors with respect to their cancer stem cell characteristics. All cell lines derived from one tumor included increased numbers of CD44+/CD24- cells, which were previously identified as human breast cancer stem cells. All cell lines derived from another mammary tumor exhibited low levels of CD44+/CD24- cells, but they harbored 2% to 5.9% CD133+ cells, which were previously associated with cancer stem cells in other human and murine tumors. When plated in the absence of attachment without presorting, only those cell lines that were enriched in either stem cell marker formed spheroids, which were further enriched in cells expressing the respective cancer stem cell marker. In contrast, cells sorted for CD44+/CD24- or CD133+ markers lost their stem cell phenotype when cultured in monolayers. As few as 50 to 100 CD44+/CD24- or CD133+ sorted cells rapidly formed tumors in nonobese diabetic/severe combined immunodeficient mice, whereas 50-fold to 100-fold higher numbers of parental or stem cell depleted cells were required to form few, slow-growing tumors. Expression of stem cell associated genes, including Oct4, Notch1, Aldh1, Fgfr1, and Sox1, was increased in CD44+/CD24- and CD133+ cells. In addition, cells sorted for cancer stem cell markers and spheroid-forming cells were significantly more resistant to DNA-damaging drugs than were parental or stem cell depleted populations, and they were sensitized to the drugs by the heat shock protein-90 inhibitor 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride). Brca1-deficient mouse mammary tumors harbor heterogeneous cancer stem cell populations, and CD44+/CD24- cells represent a population that correlates with human breast cancer stem cells. JF - Breast cancer research : BCR AU - Wright, Mollie H AU - Calcagno, Anna Maria AU - Salcido, Crystal D AU - Carlson, Marisa D AU - Ambudkar, Suresh V AU - Varticovski, Lyuba AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 1 VL - 10 IS - 1 KW - AC133 Antigen KW - 0 KW - Antigens, CD KW - Antigens, CD24 KW - Antigens, CD44 KW - BRCA1 Protein KW - BRCA1 protein, human KW - Biomarkers, Tumor KW - CD24 protein, human KW - CD44 protein, human KW - Glycoproteins KW - PROM1 protein, human KW - Peptides KW - Prom1 protein, mouse KW - Index Medicus KW - Glycoproteins -- immunology KW - Animals KW - Antigens, CD24 -- immunology KW - Antigens, CD44 -- immunology KW - Peptides -- immunology KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Female KW - Antigens, CD -- immunology KW - Breast Neoplasms -- immunology KW - Stem Cells -- immunology KW - Biomarkers, Tumor -- immunology KW - BRCA1 Protein -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69140976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+%3A+BCR&rft.atitle=Brca1+breast+tumors+contain+distinct+CD44%2B%2FCD24-+and+CD133%2B+cells+with+cancer+stem+cell+characteristics.&rft.au=Wright%2C+Mollie+H%3BCalcagno%2C+Anna+Maria%3BSalcido%2C+Crystal+D%3BCarlson%2C+Marisa+D%3BAmbudkar%2C+Suresh+V%3BVarticovski%2C+Lyuba&rft.aulast=Wright&rft.aufirst=Mollie&rft.date=2008-01-01&rft.volume=10&rft.issue=1&rft.spage=R10&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+%3A+BCR&rft.issn=1465-542X&rft_id=info:doi/10.1186%2Fbcr1855 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-11 N1 - Date created - 2008-04-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Chemother Pharmacol. 2005 Aug;56(2):115-25 [15791458] Mol Cancer Res. 2005 Oct;3(10):531-9 [16254187] Cancer Chemother Pharmacol. 2005 Nov;56 Suppl 1:64-8 [16273355] Nat Rev Cancer. 2005 Nov;5(11):899-904 [16327766] Blood. 2006 Mar 1;107(5):2162-9 [16269619] Nucleic Acids Res. 2006;34(5):1416-26 [16522651] Breast Cancer Res. 2006;8(1):R7 [16417656] J Natl Cancer Inst. 2000 Apr 5;92(7):564-9 [10749912] Nat Genet. 2001 Jul;28(3):266-71 [11431698] Crit Rev Clin Lab Sci. 2002 Nov;39(6):527-79 [12484499] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Lancet Oncol. 2003 Jun;4(6):351-8 [12788407] Science. 2003 Oct 24;302(5645):643-6 [14576434] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15853-8 [14668450] Adv Enzyme Regul. 1984;22:27-55 [6382953] Science. 1994 Oct 7;266(5182):120-2 [7939630] Science. 1994 Oct 7;266(5182):66-71 [7545954] Hum Mutat. 1996;7(4):334-9 [8723683] Oncogene. 1999 Mar 18;18(11):1957-65 [10208417] Clin Cancer Res. 2004 Dec 1;10(23):8077-84 [15585643] Hum Mutat. 2005 Mar;25(3):319 [15712267] Int J Oncol. 2005 May;26(5):1257-63 [15809716] Nat Neurosci. 2005 Jun;8(6):723-9 [15908947] Curr Top Med Chem. 2006;6(11):1193-203 [16842156] J Natl Cancer Inst. 2006 Jul 19;98(14):1011-4 [16849684] Biochem Biophys Res Commun. 2006 Sep 15;348(1):153-7 [16876126] Cancer Res. 2006 Sep 15;66(18):9211-20 [16982765] Oncogene. 2006 Sep 25;25(43):5885-97 [16998503] BMC Mol Biol. 2006;7:29 [16978418] Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5924-8 [17062662] Clin Cancer Res. 2006 Nov 1;12(21):6547-56 [17085670] Breast Cancer Res. 2006;8(5):109 [16934104] Cancer Cell. 2007 Mar;11(3):259-73 [17349583] Biochem Biophys Res Commun. 2007 Apr 20;355(4):855-9 [17307142] Expert Opin Biol Ther. 2007 Apr;7(4):431-8 [17373895] Clin Cancer Res. 2007 Apr 1;13(7):2168-77 [17404101] Stem Cells. 2007 Jul;25(7):1645-53 [17412894] Genome Biol. 2007;8(5):R76 [17493263] Cancer Res. 2007 Sep 1;67(17):8131-8 [17804725] Oncogene. 2007 Nov 8;26(51):7204-12 [17496925] Chem Biol Interact. 2008 Jan 30;171(2):159-64 [17362899] Stem Cells. 2008 Feb;26(2):364-71 [17975224] Mol Cancer. 2008;7:29 [18394172] Comment In: Breast Cancer Res. 2008;10(2):105 [18423071] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/bcr1855 ER - TY - JOUR T1 - Microbial products trigger autoimmune ocular inflammation. AN - 69117686; 18421238 AB - Microbial products stimulate the immune system by interacting with Toll-like receptors (TLR) on antigen-presenting cells. This study examined the hypothesis that microbial products, which function as TLR ligands, are playing a major role in triggering pathogenic autoimmunity. An experimental system was developed in which microbial TLR ligands were tested in vivo for their capacity to stimulate naïve CD4 cells specific against hen egg lysozyme (HEL) to become effector cells capable of inducing inflammation in eyes in which HEL is expressed. The ligands' mode of action was analyzed by determining their effects on the proliferation, acquisition of tissue-invading capacity, i.e. elevated CD49d and decreased CD62L expression, and production of interferon-gamma by the HEL-specific cells. All the 7 tested TLR ligands triggered ocular inflammation in the experimental system used here, with pertussis toxin surpassing all other ligands in its activities. A correlation was found between the capacity of the ligands to trigger pathogenic immunity and to stimulate the proliferation, modification of cell surface and interferon-gamma production by T cells. This study provides direct evidence to support the notion that microbial products are capable of triggering pathogenic autoimmunity. 2008 S. Karger AG, Basel. JF - Ophthalmic research AU - Fujimoto, Chiaki AU - Shi, Guangpu AU - Gery, Igal AD - Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892-1857, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 193 EP - 199 VL - 40 IS - 3-4 KW - Autoantigens KW - 0 KW - Bacterial Toxins KW - Integrin alpha2 KW - Ligands KW - Polysaccharides, Bacterial KW - Toll-Like Receptors KW - L-Selectin KW - 126880-86-2 KW - Interferon-gamma KW - 82115-62-6 KW - hen egg lysozyme KW - EC 3.2.1.- KW - Muramidase KW - EC 3.2.1.17 KW - Index Medicus KW - Animals KW - Integrin alpha2 -- biosynthesis KW - CD4-Positive T-Lymphocytes -- metabolism KW - Muramidase -- immunology KW - L-Selectin -- biosynthesis KW - Interferon-gamma -- biosynthesis KW - Disease Models, Animal KW - CD4-Positive T-Lymphocytes -- immunology KW - Mice KW - Mice, Transgenic KW - Bacteria -- metabolism KW - Uveitis -- pathology KW - Autoimmune Diseases -- pathology KW - Autoantigens -- immunology KW - Toll-Like Receptors -- immunology KW - Polysaccharides, Bacterial -- toxicity KW - Autoimmune Diseases -- chemically induced KW - Uveitis -- immunology KW - Bacterial Toxins -- toxicity KW - Toll-Like Receptors -- metabolism KW - Uveitis -- chemically induced KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69117686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ophthalmic+research&rft.atitle=Microbial+products+trigger+autoimmune+ocular+inflammation.&rft.au=Fujimoto%2C+Chiaki%3BShi%2C+Guangpu%3BGery%2C+Igal&rft.aulast=Fujimoto&rft.aufirst=Chiaki&rft.date=2008-01-01&rft.volume=40&rft.issue=3-4&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Ophthalmic+research&rft.issn=1423-0259&rft_id=info:doi/10.1159%2F000119875 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-12 N1 - Date created - 2008-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1999 Oct 14;401(6754):708-12 [10537110] Semin Immunol. 2007 Jun;19(3):140-52 [17400472] Immunol Rev. 2001 Aug;182:58-67 [11722623] Annu Rev Immunol. 2002;20:197-216 [11861602] Invest Ophthalmol Vis Sci. 2002 Mar;43(3):758-65 [11867595] Nat Rev Immunol. 2002 Jan;2(1):11-9 [11908514] Annu Rev Immunol. 2003;21:139-76 [12414722] J Clin Invest. 2004 Apr;113(7):990-7 [15057305] J Immunol. 2004 May 15;172(10):5967-72 [15128778] Nat Rev Immunol. 2004 Jul;4(7):499-511 [15229469] J Immunol. 1989 Mar 1;142(5):1512-7 [2645363] Cell Immunol. 1989 Aug;122(1):262-73 [2665946] J Immunol. 1990 Feb 15;144(4):1282-7 [1689349] J Exp Med. 1994 May 1;179(5):1539-49 [7909325] J Exp Med. 1997 May 5;185(9):1529-31 [9151889] Invest Ophthalmol Vis Sci. 1998 Oct;39(11):2049-57 [9761283] FASEB J. 1998 Oct;12(13):1255-65 [9761770] Adv Immunol. 1999;71:229-65 [9917915] J Immunol. 2005 Mar 1;174(5):2457-65 [15728447] Immunol Rev. 2006 Aug;212:8-27 [16903903] J Immunol. 2006 Sep 1;177(5):3362-8 [16920977] J Immunol. 2006 Nov 15;177(10):6896-903 [17082604] Annu Rev Immunol. 2007;25:821-52 [17201677] J Clin Invest. 2000 Mar;105(5):683-91 [10712440] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000119875 ER - TY - JOUR T1 - Signaling pathways controlling neural stem cells slow progressive brain disease. AN - 66713532; 19022746 AB - The identification and characterization of multipotent neural precursors open the possibility of transplant therapies, but this approach is complicated by the widespread pathology of many degenerative diseases. Activation of endogenous precursors that support regenerative mechanisms is a possible alternative. We have previously shown that Notch ligands promote stem cell survival in vitro. Here, we show that there is an intimate interaction between insulin and Notch receptor signaling. Notch ligands also expand stem cell numbers in vivo with correlated benefits in brain ischemia. We now show that insulin promotes recovery of injured dopamine neurons in the adult brain. This response suggests that activating survival mechanisms in neural stem cells will promote recovery from progressive degenerative disease. JF - Cold Spring Harbor symposia on quantitative biology AU - Androutsellis-Theotokis, A AU - Rueger, M A AU - Mkhikian, H AU - Korb, E AU - McKay, R D G AD - Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 403 EP - 410 VL - 73 KW - Basic Helix-Loop-Helix Transcription Factors KW - 0 KW - Hes3 protein, mouse KW - Insulin KW - Intracellular Signaling Peptides and Proteins KW - Ligands KW - Membrane Proteins KW - Nerve Tissue Proteins KW - Receptors, Notch KW - delta protein KW - Oxidopamine KW - 8HW4YBZ748 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Humans KW - Membrane Proteins -- metabolism KW - Membrane Proteins -- pharmacology KW - Dopamine -- metabolism KW - Insulin -- metabolism KW - Rabbits KW - Insulin -- pharmacology KW - Receptors, Notch -- metabolism KW - Rats KW - Cell Survival -- drug effects KW - Oxidopamine -- toxicity KW - Adult KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Signal Transduction KW - Stem Cells -- drug effects KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Stem Cells -- pathology KW - Brain Diseases -- pathology KW - Stem Cells -- metabolism KW - Brain Diseases -- drug therapy KW - Brain Diseases -- metabolism KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66713532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.atitle=Signaling+pathways+controlling+neural+stem+cells+slow+progressive+brain+disease.&rft.au=Androutsellis-Theotokis%2C+A%3BRueger%2C+M+A%3BMkhikian%2C+H%3BKorb%2C+E%3BMcKay%2C+R+D+G&rft.aulast=Androutsellis-Theotokis&rft.aufirst=A&rft.date=2008-01-01&rft.volume=73&rft.issue=&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.issn=1943-4456&rft_id=info:doi/10.1101%2Fsqb.2008.73.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-13 N1 - Date created - 2009-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1101/sqb.2008.73.018 ER - TY - JOUR T1 - Randomized trial comparing two treatment strategies using prize-based reinforcement of abstinence in cocaine and opiate users. AN - 66673046; 19192859 AB - We compared two strategies of prize-based contingency management (CM) in methadone-maintained outpatients. Urine was tested thrice weekly for 5 weeks pre-CM, 12 weeks CM, and 8 weeks post-CM. Participants were randomly assigned to a cocaine contingency (four prize draws for each cocaine-negative urine, N=29) or an opiate-cocaine contingency (one draw for each urine negative for opiates or cocaine, four draws if negative for both, N=38). There were no group differences in cocaine abstinence during CM or post-CM and no differences in opiate abstinence during CM. Opiate abstinence was greater in the opiate-cocaine group post-CM, and heroin craving was reduced in this group during and post-CM. Draws earned per cocaine-negative urine (four vs. one) did not affect cocaine use. JF - Journal of applied behavior analysis AU - Preston, Kenzie L AU - Ghitza, Udi E AU - Schmittner, John P AU - Schroeder, Jennifer R AU - Epstein, David H AD - National Institute on Drug Abuse, USA. Y1 - 2008 PY - 2008 DA - 2008 SP - 551 EP - 563 VL - 41 IS - 4 SN - 0021-8855, 0021-8855 KW - Index Medicus KW - Reinforcement Schedule KW - Substance Withdrawal Syndrome -- rehabilitation KW - Substance Withdrawal Syndrome -- diagnosis KW - Combined Modality Therapy KW - Substance Abuse Detection KW - Humans KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Male KW - Female KW - Community Mental Health Services KW - Token Economy KW - Motivation KW - Cocaine-Related Disorders -- psychology KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- psychology KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66673046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+behavior+analysis&rft.atitle=Randomized+trial+comparing+two+treatment+strategies+using+prize-based+reinforcement+of+abstinence+in+cocaine+and+opiate+users.&rft.au=Preston%2C+Kenzie+L%3BGhitza%2C+Udi+E%3BSchmittner%2C+John+P%3BSchroeder%2C+Jennifer+R%3BEpstein%2C+David+H&rft.aulast=Preston&rft.aufirst=Kenzie&rft.date=2008-01-01&rft.volume=41&rft.issue=4&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+behavior+analysis&rft.issn=00218855&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Clin Psychopharmacol. 1999 Nov;7(4):399-411 [10609975] J Consult Clin Psychol. 2007 Oct;75(5):765-74 [17907858] Arch Gen Psychiatry. 2000 Apr;57(4):395-404 [10768702] Exp Clin Psychopharmacol. 2000 Aug;8(3):377-86 [10975629] J Subst Abuse Treat. 2001 Jan;20(1):93-8 [11239734] Exp Clin Psychopharmacol. 2001 Feb;9(1):14-23 [11519628] Exp Clin Psychopharmacol. 2001 Aug;9(3):317-25 [11534542] J Consult Clin Psychol. 2001 Aug;69(4):643-54 [11550730] J Consult Clin Psychol. 2002 Apr;70(2):398-405 [11952198] Exp Clin Psychopharmacol. 2002 May;10(2):136-43 [12022799] J Consult Clin Psychol. 2004 Oct;72(5):839-54 [15482042] Int J Addict. 1978 Jul;13(5):737-46 [721332] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] J Pharmacol Exp Ther. 1988 Aug;246(2):441-8 [2457074] Am J Psychiatry. 1991 Sep;148(9):1218-24 [1883001] Am J Psychiatry. 1993 Apr;150(4):675 [8465894] Arch Gen Psychiatry. 1996 May;53(5):409-15 [8624184] J Consult Clin Psychol. 1997 Apr;65(2):252-61 [9086688] J Consult Clin Psychol. 1997 Jun;65(3):421-8 [9170765] J Psychopharmacol. 1998;12(1):8-14 [9584963] Am J Public Health. 1998 Jan;88(1):34-9 [9584030] J Consult Clin Psychol. 1998 Aug;66(4):691-6 [9735588] J Consult Clin Psychol. 1998 Oct;66(5):811-24 [9803700] Clin Med. 2005 Jan-Feb;5(1):69-73 [15745203] J Consult Clin Psychol. 2005 Apr;73(2):354-9 [15796645] Am J Psychiatry. 2005 Aug;162(8):1423-31 [16055763] Psychopharmacology (Berl). 2005 Sep;181(3):486-95 [16034556] Arch Gen Psychiatry. 2006 Feb;63(2):201-8 [16461864] Expert Opin Emerg Drugs. 2006 Mar;11(1):91-8 [16503828] Cochrane Database Syst Rev. 2006;(2):CD002025 [16625553] J Consult Clin Psychol. 2006 Jun;74(3):592-601 [16822115] Curr Top Med Chem. 2006;6(17):1825-43 [17017960] J Appl Behav Anal. 2007 Spring;40(1):1-13 [17471790] Drug Alcohol Depend. 2000 Feb 1;58(1-2):55-66 [10669055] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of reinforcement probability and prize size on cocaine and heroin abstinence in prize-based contingency management. AN - 66672452; 19192858 AB - Although treatment outcome in prize-based contingency management has been shown to depend on reinforcement schedule, the optimal schedule is still unknown. Therefore, we conducted a retrospective analysis of data from a randomized clinical trial (Ghitza et al., 2007) to determine the effects of the probability of winning a prize (low vs. high) and the size of the prize won (small, large, or jumbo) on likelihood of abstinence until the next urine-collection day for heroin and cocaine users (N=116) in methadone maintenance. Higher probability of winning, but not the size of individual prizes, was associated with a greater percentage of cocaine-negative, but not opiate-negative, urines. JF - Journal of applied behavior analysis AU - Ghitza, Udi E AU - Epstein, David H AU - Schmittner, John AU - Vahabzadeh, Massoud AU - Lin, Jia-Ling AU - Preston, Kenzie L AD - National Institute on Drug Abuse, Clinical Pharmacology and Therapeutics Research Branch/Treatment Section, 251 Bayview Boulevard, Suite 200, Baltimore, Maryland 21224, USA. ghitzau@nida.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 539 EP - 549 VL - 41 IS - 4 SN - 0021-8855, 0021-8855 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Reinforcement Schedule KW - Patient Compliance KW - Substance Abuse Detection KW - Humans KW - Adult KW - Retrospective Studies KW - Conditioning, Operant KW - Middle Aged KW - Male KW - Female KW - Probability KW - Token Economy KW - Motivation KW - Reinforcement (Psychology) KW - Heroin Dependence -- rehabilitation KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66672452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+behavior+analysis&rft.atitle=Effect+of+reinforcement+probability+and+prize+size+on+cocaine+and+heroin+abstinence+in+prize-based+contingency+management.&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BSchmittner%2C+John%3BVahabzadeh%2C+Massoud%3BLin%2C+Jia-Ling%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2008-01-01&rft.volume=41&rft.issue=4&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+behavior+analysis&rft.issn=00218855&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Clin Psychopharmacol. 1999 Nov;7(4):399-411 [10609975] Drug Alcohol Depend. 2000 Feb 1;58(1-2):103-9 [10669060] Drug Alcohol Depend. 2000 Feb 1;58(1-2):205-12 [10669073] Exp Clin Psychopharmacol. 2000 Aug;8(3):377-86 [10975629] Behav Brain Sci. 2000 Feb;23(1):73-90; discussion 90-130 [11303339] Exp Clin Psychopharmacol. 2001 Aug;9(3):317-25 [11534542] J Consult Clin Psychol. 2001 Aug;69(4):643-54 [11550730] J Consult Clin Psychol. 2002 Apr;70(2):398-405 [11952198] Psychol Addict Behav. 2003 Mar;17(1):73-82 [12665084] Exp Clin Psychopharmacol. 2003 Nov;11(4):302-8 [14599264] Addiction. 2004 Mar;99(3):349-60 [14982548] Exp Clin Psychopharmacol. 2004 May;12(2):147-55 [15122959] Drug Alcohol Depend. 2004 Jul 15;75(1):97-106 [15225893] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] Am J Psychiatry. 1991 Sep;148(9):1218-24 [1883001] Arch Gen Psychiatry. 1996 May;53(5):409-15 [8624184] Drug Alcohol Depend. 1996 Jun;41(2):157-65 [8809505] Am J Psychiatry. 2006 Nov;163(11):1993-9 [17074952] Addiction. 2007 Feb;102(2):271-81 [17222282] Psychiatry Res. 2006 Sep 30;144(1):91-3 [16905197] J Consult Clin Psychol. 2007 Oct;75(5):765-74 [17907858] J Appl Behav Anal. 2007 Fall;40(3):387-410 [17970256] J Consult Clin Psychol. 1998 Aug;66(4):691-6 [9735588] J Consult Clin Psychol. 1998 Oct;66(5):761-7 [9803694] J Consult Clin Psychol. 1998 Oct;66(5):811-24 [9803700] Drug Alcohol Depend. 2004 Dec 7;76(3):247-59 [15561476] Exp Clin Psychopharmacol. 2005 May;13(2):83-92 [15943541] Arch Gen Psychiatry. 2005 Oct;62(10):1148-56 [16203960] J Consult Clin Psychol. 2005 Dec;73(6):1005-14 [16392974] Addiction. 2006 Feb;101(2):192-203 [16445548] Arch Gen Psychiatry. 2006 Feb;63(2):201-8 [16461864] Exp Clin Psychopharmacol. 2006 May;14(2):171-9 [16756421] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - How Do We Acquire Parental Responsibilities? AN - 61694775; 200813686 AB - This paper presents a theory of the origins of parental responsibilities that can be used to resolve cases in which people deny their moral responsibility for their biological offspring; ie, they dispute their moral parenthood. Presented as an example is the case of the accidental father -- in which impregnation took place during voluntary intercourse even though both the man & his partner took the normally expected precautions against pregnancy. His denial of parental responsibility implies that men & women have different moral powers without relevant differences; ie, their respective responsibility is out of proportion to their risk. Millum explains why some parental responsibilities need not be in proportion to the act that produces them & suggests that complaints about this inequality are better directed against social conventions of parenting than of parental responsibility. These claims are justified by an account of how parental responsibilities are acquired. It is theorized that parental responsibilities are taken on through acts that social convention dictates lead to the acquisition of responsibility. In Anglo-American society, men normally acquire parental responsibilities through engaging in sexual intercourse that leads to conception, no matter what our views about (in)equality in parenthood. S. Stanton JF - Social Theory and Practice AU - Millum, Joseph AD - Dept Bioethics, National Instits Health millumj@cc.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 71 EP - 93 PB - Florida State University, Tallahassee FL VL - 34 IS - 1 SN - 0037-802X, 0037-802X KW - Morality KW - Responsibility KW - Parents KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61694775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Theory+and+Practice&rft.atitle=How+Do+We+Acquire+Parental+Responsibilities%3F&rft.au=Millum%2C+Joseph&rft.aulast=Millum&rft.aufirst=Joseph&rft.date=2008-01-01&rft.volume=34&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Social+Theory+and+Practice&rft.issn=0037802X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-28 N1 - CODEN - STYPAM N1 - SubjectsTermNotLitGenreText - Parents; Responsibility; Morality ER - TY - JOUR T1 - Families by Adoption and Birth: I. Mother-Infant Socioemotional Interactions AN - 61402959; 200901325 AB - The role of adoptive family dynamics in the etiology of both resilient and adverse developmental outcomes is not well understood. In this study, socio-emotional aspects of the mother-infant relationship were examined in families by adoption and by birth. Matched groups of mothers and their 5-month-old first babies were observed in the home setting. Dyads in the two groups were comparable in the frequency and ranking of a full array of age-appropriate behaviors. Group differences emerged for selected infant and maternal behaviors; infants by birth were in an alert state and smiled more often than infants by adoption, and adoptive mothers nourished and caressed their infants more than did mothers by birth. While the structure of the infants behavior repertoire was similar for both groups, there were twice as many significant correlations among maternal behaviors for the birth group than for the adoptive group. There were also more correlations between maternal and infant behaviors for dyads by birth than for dyads by adoption, and the nature of the correlations differed for the two groups. It is argued that both groups of mothers and babies were functioning in the adaptive, healthy range and that observed differences between them reflect subtle differences in behavioral emphasis, possibly related to the unique paths to parenthood represented by adoption and birth. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Adoption Quarterly AU - Suwalsky, Joan T D AU - Hendricks, Charlene AU - Bornstein, Marc H AD - Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockledge 1, Suite 8030, 6705 Rockledge Drive, MSC 7971, Bethesda, MD 20892-7971 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 101 EP - 125 PB - Haworth Press/Taylor & Francis, Philadelphia, PA VL - 11 IS - 2 SN - 1092-6755, 1092-6755 KW - Adoption, infancy, socio-emotional development KW - Resilience KW - Emotions KW - Family KW - Adoption KW - Development KW - Children KW - Infants KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61402959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adoption+Quarterly&rft.atitle=Families+by+Adoption+and+Birth%3A+I.+Mother-Infant+Socioemotional+Interactions&rft.au=Suwalsky%2C+Joan+T+D%3BHendricks%2C+Charlene%3BBornstein%2C+Marc+H&rft.aulast=Suwalsky&rft.aufirst=Joan+T&rft.date=2008-01-01&rft.volume=11&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Adoption+Quarterly&rft.issn=10926755&rft_id=info:doi/10.1080%2F10926750802374942 LA - English DB - Social Services Abstracts N1 - Date revised - 2009-02-03 N1 - Number of references - 59 N1 - Last updated - 2016-09-28 N1 - CODEN - ADQUFW N1 - SubjectsTermNotLitGenreText - Infants; Children; Adoption; Family; Development; Emotions; Resilience DO - http://dx.doi.org/10.1080/10926750802374942 ER - TY - JOUR T1 - Parenting Behavior and Adolescent Conduct Problems: Reciprocal and Mediational Effects AN - 61401233; 200804037 AB - This research examined the relationship between parenting practices and adolescent conduct problems and the mediation of these relationships by two parent-adolescent relationship variables, conflict and psychological autonomy. Autoregressive latent trajectory (ALT) analyses were used to assess relationships over time between parent practices and adolescent conduct problems. Participants were 2,453 students recruited from 7 public middle schools and assessed 5 times between fall of 6th and 9th grades on the following measures: Parent Monitoring; Parent Knowledge; adolescent Psychological Autonomy; parent-adolescent Conflict; and adolescent Conduct Problems. Adolescent Conduct Problems and parenting practices were associated in both cross-sectional and prospective analyses. In time-lagged autoregressive modeling as a part of ALT analyses, adolescent Conduct Problems and parenting practices were reciprocally related from Time 1 to Time 2, but there after only Parent Monitoring was consistently associated with adolescent Conduct Problems over time. Adolescent Psychological Autonomy positively mediated the relationships between adolescent Conduct Problems and Parent Monitoring, but not the relationship between Parental Knowledge and Conduct Problems; while Conflict partially mediated the relationships between the slope of Conduct Problems and the slopes of both parenting behaviors and the relationship between the slopes of Conduct Problems and Psychological Autonomy. The findings provide evidence of reciprocal relationships between Conduct Problems and parenting behaviors and parent-teen relationship variables. Mediational analyses indicated relationships with Conduct Problems unmediated by Autonomy and partially mediated by Conflict. The findings provide support for the hypothesis that associations over time between parenting practices and adolescent Conduct Problems depend in part on the parent-adolescent relationship. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of School Violence AU - Simons-Morton, Bruce AU - Chen, Rusan AU - Hand, Laura Shaffer AU - Haynie, Denise L AD - National Institute of Child Health and Human Development, Prevention Research Branch, DESPR, NICHD, NIH, 6100 Executive Boulevard, 7B13M Bethesda, MD 20892-75 10 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 3 EP - 25 PB - Haworth Press, Binghamton NY VL - 7 IS - 1 SN - 1538-8220, 1538-8220 KW - Misconduct, aggression, anti-social behavior, social influence, latent growth modeling, autoregressive analyses KW - Psychological Factors KW - Emotional Abuse KW - Adolescent Parents KW - Autonomy KW - Social Influence KW - Parent Child Relations KW - Behavior Problems KW - Methodological Problems KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61401233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+School+Violence&rft.atitle=Parenting+Behavior+and+Adolescent+Conduct+Problems%3A+Reciprocal+and+Mediational+Effects&rft.au=Simons-Morton%2C+Bruce%3BChen%2C+Rusan%3BHand%2C+Laura+Shaffer%3BHaynie%2C+Denise+L&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2008-01-01&rft.volume=7&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+School+Violence&rft.issn=15388220&rft_id=info:doi/10.1300%2FJ202v07n01_02 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-06-11 N1 - Number of references - 51 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Adolescent Parents; Parent Child Relations; Behavior Problems; Autonomy; Emotional Abuse; Social Influence; Methodological Problems; Psychological Factors DO - http://dx.doi.org/10.1300/J202v07n01_02 ER - TY - JOUR T1 - 10 Things to Know about Evaluating Medical Resources on the Web AN - 57725135; 200903708 AB - The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading. This article presents ten important questions that should be considered when looking for health information online. Answering these questions when visiting a new site will help users evaluate the information they find: who runs the site, who pays for the site, what is the purpose of the site, where does the information come from, what is the basis of the information, how is the information selected, how current is the information, how does the site choose links to other sites, what information about the searcher does the site collect and why, and how does the site manage interactions with visitors. Adapted from the source document. JF - The Unabashed Librarian AU - National Cancer Institute AD - National Cancer Institute Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 29 EP - 32 PB - PO Box 325, Mount Kisco, NY 10549 IS - 149 SN - 0049-514X, 0049-514X KW - Web sites KW - Consumer health information KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57725135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Unabashed+Librarian&rft.atitle=10+Things+to+Know+about+Evaluating+Medical+Resources+on+the+Web&rft.au=National+Cancer+Institute&rft.aulast=National+Cancer+Institute&rft.aufirst=&rft.date=2008-01-01&rft.volume=&rft.issue=149&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=The+Unabashed+Librarian&rft.issn=0049514X&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumer health information; Web sites ER - TY - JOUR T1 - Laws, leaders, and legends of the modern National Library of Medicine. AN - 57708135; 200804798 AB - Purpose: The paper is an expanded version of the 2007 Joseph Leiter National Library of Medicine (NLM)/Medical Library Association Lecture presented at MLA '07, the Medical Library Association annual meeting in Philadelphia in May 2007. It presents an historical accounting of four major pieces of legislation, beginning with the NLM Act of 1956 up through the creation of the National Center for Biotechnology Information. Brief Description: The transition from the United States Armed Forces Medical Library to the United States National Library of Medicine in 1956 was a major turning point in NLM's history, scope, and direction. The succeeding landmark legislative achievements - namely, the 1965 Medical Library Assistance Act, the 1968 Joint Resolution forming the Lister Hill National Center for Biomedical Communications, and the 1988 authorization for the National Center for Biotechnology Information - transformed the library into a major biomedical communications institution and a leader and supporter of an effective national network of libraries of medicine. The leaders of the library and its major advocates - including Dr. Michael DeBakey, Senator Lister Hill, and Senator Claude Pepper - together contributed to the creation of the modern NLM. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Smith, Kent A AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894 ksmith@kasenterprise.com Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 121 EP - 133 PB - Medical Library Association, Chicago, IL VL - 96 IS - 2 SN - 1536-5050, 1536-5050 KW - National Library of Medicine, USA KW - Law KW - Library history KW - Medical libraries KW - article KW - 3.19: SCIENCE, TECHNOLOGY, MEDICINE LIBRARIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57708135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Laws%2C+leaders%2C+and+legends+of+the+modern+National+Library+of+Medicine.&rft.au=Smith%2C+Kent+A&rft.aulast=Smith&rft.aufirst=Kent&rft.date=2008-01-01&rft.volume=96&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.96.2.121 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical libraries; Library history; Law; National Library of Medicine, USA DO - http://dx.doi.org/10.3163/1536-5050.96.2.121 ER - TY - JOUR T1 - Automated classification and retrieval of reusable software components. AN - 57703018; 200802654 AB - The authors describe their research which improves software reuse by using an automated approach to semantically search for and retrieve reusable software components in large software component repositories and on the World Wide Web (WWW). Using automation and smart (semantic) techniques, their approach speeds up the search and retrieval of reusable software components, while retaining good accuracy, and therefore improves the affordability of software reuse. A program understanding of software components and natural language understanding of user queries was employed. Then the software component descriptions were compared by matching the resulting semantic representations of the user queries to the semantic representations of the software components to search for software components that best match the user queries. A proof of concept system was developed to test the authors' approach. The results of this proof of concept system were compared to human experts, and statistical analysis was performed on the collected experimental data. The results from these experiments demonstrate that this automated semantic-based approach for software reusable component classification and retrieval is successful when compared to the labor-intensive results from the experts, thus showing that this approach can significantly benefit software reuse classification and retrieval. [Copyright 2008 Wiley Periodicals Inc.] JF - Journal of the American Society for Information Science and Technology AU - Yao, Haining AU - Etzkorn, Letha H AU - Virani, Shamsnaz AD - National Library of Medicine, National Institutes of Health, Bethesda, MD hy77t@nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 613 EP - 627 PB - Wiley Subscription Services, Hoboken NJ VL - 59 IS - 4 SN - 1532-2882, 1532-2882 KW - Software KW - Search strategies KW - Automatic classification KW - article KW - 13.14: INFORMATION STORAGE AND RETRIEVAL - SEARCHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57703018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.atitle=Automated+classification+and+retrieval+of+reusable+software+components.&rft.au=Yao%2C+Haining%3BEtzkorn%2C+Letha+H%3BVirani%2C+Shamsnaz&rft.aulast=Yao&rft.aufirst=Haining&rft.date=2008-01-01&rft.volume=59&rft.issue=4&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.issn=15322882&rft_id=info:doi/10.1002%2Fasi.20775 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Search strategies; Automatic classification; Software DO - http://dx.doi.org/10.1002/asi.20775 ER - TY - JOUR T1 - Effect of Adding a Virtual Community (Bulletin Board) to Smokefree.gov: Randomized Controlled Trial AN - 57688494; 200904740 AB - Background: Demand for online information and help exceeds most other forms of self-help. Web-assisted tobacco interventions (WATIs) offer a potentially low-cost way to reach millions of smokers who wish to quit smoking and to test various forms of online assistance for use/utilization and user satisfaction. Objectives: Our primary aim was to determine the utilization of and satisfaction with 2 versions of a smoking cessation website (smokefree.gov), one of which included an asynchronous bulletin board (BB condition). A secondary goal was to measure changes in smoking behavior 3 months after enrollment in the study. Methods: All participants were adult federal employees or contractors to the federal government who responded to an email and indicated a willingness to quit smoking in 30 days. We randomly assigned participants to either the BB condition or the publicly available version-usual care (UC)-and then assessed the number of minutes of website use and satisfaction with each condition as well as changes in smoking behavior. Results: Among the 1375 participants, 684 were randomized to the BB intervention, and 691 to the control UC condition. A total of 39.7% returned a follow-up questionnaire after 3 months, with similar rates across the two groups (UC: n=279, 40.3%; BB: n=267, 39.0%). Among those respondents assigned to the BB condition, only 81 participants (11.8%) elected to view the bulletin board or post a message, limiting our ability to analyze the impact of bulletin board use on cessation. Satisfaction with the website was high and did not differ significantly between conditions (UC: 90.2%, BB: 84.9%, P= .08). Utilization, or minutes spent on the website, was significantly longer for the BB than the UC condition (18.0 vs. 11.1, P = .01) and was nearly double for those who remained in the study (21.2) than for those lost to follow-up (9.6, P< .001). Similar differences were observed between those who made a serious quit attempt versus those who did not (22.4 vs. 10.4, P= .02) and between those with a quit date on or a few days prior to the enrollment date versus those with a later quit date (29.4 vs. 12.5, P = .001). There were no statistically significant differences in quit rates between the BB and UC group, both in intent-to-treat analysis (ITT) and in analyzing the adherence subgroup (respondents) only. Combined across the UC and BB groups, 7-day abstinence was 6.8% with ITT and 17.6% using only participants in the follow-up (adherence). For participants who attempted to quit within a few days of study entry (vs. 30 days), quit rates were 29.6% (ITT) and 44.4% (adherence). Conclusions: Quit rates for participants were similar to other WATIs, with the most favorable outcomes demonstrated by smokers ready to quit at the time of enrolling in the trial and smokers using pharmacotherapy. Utilization of the asynchronous bulletin board was lower than expected, and did not have an impact on outcomes (quit rates). Given the demand for credible online resources for smoking cessation, future studies should continue to evaluate use of and satisfaction with Web features and to clarify results in terms of time since last cigarette as well as use of pharmacotherapy. Adapted from the source document. JF - Journal of Medical Internet Research AU - Stoddard, Jacqueline AU - Augustson, Erik AU - Moser, Rick AD - National Cancer Institute, 6130 Executive Boulevard, EPN 4038, Rockville, MD 21702 stoddaja@mail.nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth nnovation, Toronto, Canada VL - 10 IS - 5 SN - 1438-8871, 1438-8871 KW - Smoking cessation, Internet, World Wide Web, randomized trial, self-help KW - Virtual communities KW - Tobacco KW - Consumer health information KW - Internet KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57688494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Effect+of+Adding+a+Virtual+Community+%28Bulletin+Board%29+to+Smokefree.gov%3A+Randomized+Controlled+Trial&rft.au=Stoddard%2C+Jacqueline%3BAugustson%2C+Erik%3BMoser%2C+Rick&rft.aulast=Stoddard&rft.aufirst=Jacqueline&rft.date=2008-01-01&rft.volume=10&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/ L2 - http://www.jmir.org/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumer health information; Virtual communities; Tobacco; Internet ER - TY - JOUR T1 - Affirming our commitment to research: the Medical Library Association's research policy statement: the process and findings. AN - 57628082; 200804797 AB - Purpose: Building on its 1995 research policy statement, the Medical Library Association (MLA) has issued a new research policy, The Research Imperative. This paper shares the background research that informed the new policy. Methods: Semi-structured interviews were conducted with fifty-one key informants representing various library types, functions, geographic locations, ages, and ethnicities. The grounded theory approach was used to analyze the resulting textual database. Additionally, to gather input from the membership as a whole, two open forums were held at MLA annual meetings. Results: Key informant data indicated that the policy should provide roles for MLA in leadership, advocacy, collaboration, services, education, publishing, and development of a research agenda. Evidence-based library and information practice was emphasized. Six themes emerged to center the new policy: creation of a research culture, challenges, domains of research, research skills set, roles of stakeholders, and measurement of progress. Conclusion: Reflecting the interests and beliefs of the membership, The Research Imperative challenges MLA members to build a supportive culture that values and contributes to a research base that is recognized as an essential tool for future practice. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Grefsheim, Suzanne F AU - Rankin, Jocelyn A AU - Perry, Gerald J AU - McKibbon, K Ann AD - Division of Library Services, National Institutes of Health, 10 Center Drive, MSC-1150, Bethesda, MD 20892 grefshes@nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 114 EP - 120 PB - Medical Library Association, Chicago, IL VL - 96 IS - 2 SN - 1536-5050, 1536-5050 KW - Medical libraries KW - Research KW - Medical Library Association, USA KW - article KW - 3.19: SCIENCE, TECHNOLOGY, MEDICINE LIBRARIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57628082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Affirming+our+commitment+to+research%3A+the+Medical+Library+Association%27s+research+policy+statement%3A+the+process+and+findings.&rft.au=Grefsheim%2C+Suzanne+F%3BRankin%2C+Jocelyn+A%3BPerry%2C+Gerald+J%3BMcKibbon%2C+K+Ann&rft.aulast=Grefsheim&rft.aufirst=Suzanne&rft.date=2008-01-01&rft.volume=96&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.96.2.114 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical libraries; Research; Medical Library Association, USA DO - http://dx.doi.org/10.3163/1536-5050.96.2.114 ER - TY - JOUR T1 - Making a Connection: The Use of Storytelling as a Strategy to Enhance Faculty's Success with Latina Nursing Students AN - 57291271; 200910310 AB - The purpose of this article is to assist faculty in gaining a deeper understanding of the educational experiences of Latina nursing students. Through the use of participant profiles, the personal stories of three Latina nursing students are presented. The Process of Cultural Competence in the Delivery of Healthcare Services Model serves as the theoretical framework of the study. It is the premise of this article that the storytelling of these students' educational experiences can provide faculty with a rich source of information to connect with culturally and ethnically diverse nursing students. In turn, this connection can lead to the development of culturally responsive recruitment and retention strategies for Latino/a students. Adapted from the source document. JF - Hispanic Health Care International AU - Rivera-Goba, Migdalia V AU - Campinha-Bacote, Josepha AD - National Institutes of Health, Bethesda, MD Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 205 EP - 225 PB - Springer Publishing Company, New York NY VL - 6 IS - 4 SN - 1540-4153, 1540-4153 KW - Latino/Hispanic students KW - perseverance KW - participant profiles KW - cultural competency KW - compassion KW - Latin American people KW - Care delivery KW - Nursing KW - Recruitment KW - Storytelling KW - Professors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57291271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hispanic+Health+Care+International&rft.atitle=Making+a+Connection%3A+The+Use+of+Storytelling+as+a+Strategy+to+Enhance+Faculty%27s+Success+with+Latina+Nursing+Students&rft.au=Rivera-Goba%2C+Migdalia+V%3BCampinha-Bacote%2C+Josepha&rft.aulast=Rivera-Goba&rft.aufirst=Migdalia&rft.date=2008-01-01&rft.volume=6&rft.issue=4&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Hispanic+Health+Care+International&rft.issn=15404153&rft_id=info:doi/10.1891%2F1540-4153.6.4.205 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nursing; Latin American people; Professors; Storytelling; Care delivery; Recruitment DO - http://dx.doi.org/10.1891/1540-4153.6.4.205 ER - TY - JOUR T1 - Perspective: Eyes on the prize: Federal Alzheimer's research effort aims to facilitate interventions AN - 57290372; 200915133 AB - The public Alzheimer's disease (AD) research enterprise began in earnest in the mid-1970s with the creation by Congress of the National Institute on Aging at the National Institutes of Health. Today, AD research is a maturing field of study, with federal effort seeking to encourage the creativity and insights of individual investigators, and targeting special areas for emphasis. It is inspired by the legacy of our friend and colleague Leon Thal, whose innovative and collaborative approach to scientific research serves as a guidepost as we move toward the discovery of new and effective ways to prevent AD or slow its progression. This article describes the progress to date and potentially promising areas of study from the vantage point of the National Institute on Aging. [Copyright Elsevier B.V.] JF - Alzheimer's & Dementia AU - Hodes, Richard J AU - Buckholtz, Neil AU - Cahan, Vicky AU - Morrison-Bogorad, Marcelle AD - National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA Y1 - 2008/01// PY - 2008 DA - January 2008 SP - S37 EP - S47 PB - Elsevier Ltd, The Netherlands VL - 4 IS - 1S1 SN - 1552-5260, 1552-5260 KW - Alzheimer's disease National Institute on Aging Dementia KW - Ageing KW - Congress KW - Alzheimer's disease KW - Creativity KW - Enterprises KW - Eyes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57290372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alzheimer%27s+%26+Dementia&rft.atitle=Perspective%3A+Eyes+on+the+prize%3A+Federal+Alzheimer%27s+research+effort+aims+to+facilitate+interventions&rft.au=Hodes%2C+Richard+J%3BBuckholtz%2C+Neil%3BCahan%2C+Vicky%3BMorrison-Bogorad%2C+Marcelle&rft.aulast=Hodes&rft.aufirst=Richard&rft.date=2008-01-01&rft.volume=4&rft.issue=1S1&rft.spage=S37&rft.isbn=&rft.btitle=&rft.title=Alzheimer%27s+%26+Dementia&rft.issn=15525260&rft_id=info:doi/10.1016%2Fj.jalz.2007.11.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alzheimer's disease; Ageing; Enterprises; Congress; Eyes; Creativity DO - http://dx.doi.org/10.1016/j.jalz.2007.11.002 ER - TY - JOUR T1 - Emerging Hispanic Leaders in Health Care: Forging Relationships to Maximize Personal and Professional Development AN - 57277218; 200908235 AB - The Clinical Center at the National Institutes of Health, the nation's largest hospital devoted to clinical research, provides training opportunities through the Intramural Research Training Award (IRTA). Our collective experience as IRTA interns is captured in three interrelated connectors: confidence, learning opportunities, and mentoring. Building confidence occurs by successfully completing unfamiliar tasks and developing projects to completion. Learning opportunities encompass both clinical practice and research. Effective mentoring extends beyond giving career guidance demonstrated by our mentor's commitment and positive approach to our overall well-being to leading us through new and challenging situations. In summary, all three processes are connectors that have been instrumental in our accomplishments. Knowing, applying, and embracing all available opportunities are essential steps for emerging leaders to shape health care. Adapted from the source document. JF - Hispanic Health Care International AU - Bayard, Micaela F AU - Hassanshahi, Farahnaz AU - Dominguez, Leticia C AU - Rivera-Goba, Migdalia V AD - National Institutes of Health, Clinical Center, Bethesda, MD Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 226 EP - 236 PB - Springer Publishing Company, New York NY VL - 6 IS - 4 SN - 1540-4153, 1540-4153 KW - Mentoring KW - Hispanic/Latino students KW - leadership KW - Intramural Research Training Award (IRTA) KW - Learning KW - Health care KW - Clinical research KW - Leaders KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57277218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hispanic+Health+Care+International&rft.atitle=Emerging+Hispanic+Leaders+in+Health+Care%3A+Forging+Relationships+to+Maximize+Personal+and+Professional+Development&rft.au=Bayard%2C+Micaela+F%3BHassanshahi%2C+Farahnaz%3BDominguez%2C+Leticia+C%3BRivera-Goba%2C+Migdalia+V&rft.aulast=Bayard&rft.aufirst=Micaela&rft.date=2008-01-01&rft.volume=6&rft.issue=4&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Hispanic+Health+Care+International&rft.issn=15404153&rft_id=info:doi/10.1891%2F1540-4153.6.4.226 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Mentoring; Learning; Health care; Clinical research; Leaders; Hospitals DO - http://dx.doi.org/10.1891/1540-4153.6.4.226 ER - TY - JOUR T1 - Jonathan Mann, HIV/AIDS, and Human Rights AN - 57268275; 200821440 AB - The early association of HIV/AIDS with marginal groups - homosexuals and IV drug users - structured social and political responses to the disease. Many countries began to enact restrictive travel policies and to contemplate compulsory testing or quarantine for those infected. In Africa, Jonathan Mann became convinced that the disease was heterosexually transmitted and had the potential to become a worldwide pandemic. He convinced Halfden Mahler, Director General of WHO, who appointed him director of the WHO's Global Programme on AIDS. In this position, and because of his eloquence and passion, Mann was able to mobilize ministers of health around the world. Mann argued that AIDS was a social disease, flourishing in conditions of poverty, oppression, urban migration, gender inequality, and violence. He advanced a new way of understanding AIDS and AIDS policies based on a human rights framework. Adapted from the source document. JF - Journal of Public Health Policy AU - Fee, Elizabeth AU - Parry, Manon AD - National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA feee@mail.nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 54 EP - 71 PB - Palgrave Macmillan, Basingstoke UK VL - 29 IS - 1 SN - 0197-5897, 0197-5897 KW - World Health Organization KW - Human rights KW - Epidemics KW - AIDS KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57268275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health+Policy&rft.atitle=Jonathan+Mann%2C+HIV%2FAIDS%2C+and+Human+Rights&rft.au=Fee%2C+Elizabeth%3BParry%2C+Manon&rft.aulast=Fee&rft.aufirst=Elizabeth&rft.date=2008-01-01&rft.volume=29&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health+Policy&rft.issn=01975897&rft_id=info:doi/10.1057%2Fpalgrave.jphp.3200160 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPODK N1 - SubjectsTermNotLitGenreText - AIDS; Human rights; HIV; World Health Organization; Epidemics DO - http://dx.doi.org/10.1057/palgrave.jphp.3200160 ER - TY - JOUR T1 - Social Competence with Peers in Third Grade: Associations with Earlier Peer Experiences in Childcare AN - 57265410; 200822306 AB - The early developmental antecedents of individual differences in children's social functioning with peers in third grade were examined using longitudinal data from the large-scale National Institute of Child Health and Human Development (NICHD) study of early child care. In a sample of 1,364 children, with family and child factors controlled, the frequency of positive and negative peer interactions in childcare between 24 and 54 months and the number of hours spent in childcare peer groups of different sizes (alone, dyad, small, medium, large) predicted third graders' peer competence at three levels of analysis: individual social skills, dyadic friendships, and peer-group acceptance. Children who had more positive experiences with peers in childcare had better social and communicative skills with peers in third grade, were more sociable and co-operative and less aggressive, had more close friends, and were more accepted and popular. Children with more frequent negative experiences with peers in childcare were more aggressive in third grade, had lower social and communicative skills, and reported having fewer friends. When children spent more time in small-sized peer groups in childcare (four or fewer children at 24 months of age up to seven or fewer at 54 months), they were more sociable and co-operative in third grade, but their teachers rated them as more aggressive, suggesting that such children may be more socially outgoing and active both positively and negatively. Like those who spent more time in small peer groups, children who spent more hours in medium-sized groups received higher ratings for peer aggression by their third-grade teachers. Children who spent more time with one other child in childcare or in small peer groups had fewer classroom friends in third grade as reported by the teacher but not according to maternal report or self-report. There were no significant associations between the amount of time children spent in large childcare-based peer groups and third-grade peer social competence. Adapted from the source document. JF - Social Development AU - NICHD AD - NICHD; c/o Celia Brownell, Dept Psychology, U Pittsburgh brownell@pitt.edu Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 419 EP - 453 PB - Blackwell Publishers, Oxford UK VL - 17 IS - 3 SN - 0961-205X, 0961-205X KW - Peer acceptance KW - Social skills KW - Social competence KW - Peer groups KW - Children KW - Child care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57265410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Development&rft.atitle=Social+Competence+with+Peers+in+Third+Grade%3A+Associations+with+Earlier+Peer+Experiences+in+Childcare&rft.au=NICHD&rft.aulast=NICHD&rft.aufirst=&rft.date=2008-01-01&rft.volume=17&rft.issue=3&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Social+Development&rft.issn=0961205X&rft_id=info:doi/10.1111%2Fj.1467-9507.2007.00446.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Children; Child care; Peer groups; Social skills; Social competence; Peer acceptance DO - http://dx.doi.org/10.1111/j.1467-9507.2007.00446.x ER - TY - JOUR T1 - Characterizing the hoarding phenotype in individuals with OCD: Associations with comorbidity, severity and gender AN - 57257793; 200907902 AB - Hoarding frequently occurs in obsessive-compulsive disorder (OCD), and some evidence suggests that it constitutes a distinct OCD subtype, with genetic contributions. This study investigated differences between OCD patients with and without hoarding symptoms. Of the 473 OCD patients studied, 24% were classified as hoarders according to combined interviewer and self-ratings, which were validated with the Savings Inventory-Revised in a subsample. Hoarders suffered from significantly more severe OCD symptoms, (especially compulsions) and had greater impairment and dysphoria. Hoarders also had more comorbid psychiatric disorders. Further study revealed that many of these differences were attributable to the female subjects: Compared to female non-hoarders, female hoarders were more likely to suffer from bipolar I, substance abuse, panic disorder, binge-eating disorder, and had greater OCD severity. Male hoarders had an increased prevalence of social phobia compared to non-hoarding males. These results suggest that there are gender-specific differences in the hoarding sub-phenotype of OCD. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Wheaton, Michael AU - Timpano, Kiara R AU - Lasalle-Ricci, V Holland AU - Murphy, Dennis AD - Laboratory of Clinical Science, National Institute of Mental Health, United States Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 243 EP - 252 PB - Elsevier Ltd, The Netherlands VL - 22 IS - 2 SN - 0887-6185, 0887-6185 KW - Obsessive-compulsive disorder Gender Comorbidity Anxiety KW - Anxiety KW - Hoarding KW - Gender differences KW - Comorbidity KW - Obsessive-Compulsive neuroses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57257793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Characterizing+the+hoarding+phenotype+in+individuals+with+OCD%3A+Associations+with+comorbidity%2C+severity+and+gender&rft.au=Wheaton%2C+Michael%3BTimpano%2C+Kiara+R%3BLasalle-Ricci%2C+V+Holland%3BMurphy%2C+Dennis&rft.aulast=Wheaton&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=22&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Journal+of+Anxiety+Disorders&rft.issn=08876185&rft_id=info:doi/10.1016%2Fj.janxdis.2007.01.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Obsessive-Compulsive neuroses; Gender differences; Hoarding; Comorbidity; Anxiety DO - http://dx.doi.org/10.1016/j.janxdis.2007.01.015 ER - TY - JOUR T1 - Social Networks and Participation in Social Activities at a New Senior Center: Reaching Out to Older Adults Who Could Benefit the Most AN - 57253904; 200820926 AB - This study examined social network characteristics associated with older adults' intentions to participate and actual participation in social activities at a new senior center. Face-to-face interviews (N = 126) were conducted prior to the opening of a senior center in the participants' community. Measures included social network characteristics, social support, social connectedness, and demographic characteristics. Actual participation was assessed approximately 14 months after the senior center's opening. Smaller proportions of network members living in close proximity, having 10% or more network members be children, higher perceived availability of social support, and lower perceived levels of social connectedness were associated with higher intentions to participate in social activities. Levels of intention did not significantly predict actual participation. Older adults with little social support may not perceive senior centers as places to gain desired support. However, individuals who lack companionship may perceive them as a resource for boosting their social engagement. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Activities, Adaptation and Aging AU - Ashida, Sato AU - Heaney, Catherine A AD - National Human Genome Research Institute, 31 Center Drive B1B37C , Bethesda, MD, 20892-2073 ashidas@mail.nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 40 EP - 58 PB - The Haworth Press, Binghamton NY VL - 32 IS - 1 SN - 0192-4788, 0192-4788 KW - Social support, social connectedness, social engagement, community dwelling, senior center, face-to-face interviews KW - Elderly people KW - Social networks KW - Social support KW - Connectedness KW - Proximity KW - Social activities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Activities%2C+Adaptation+and+Aging&rft.atitle=Social+Networks+and+Participation+in+Social+Activities+at+a+New+Senior+Center%3A+Reaching+Out+to+Older+Adults+Who+Could+Benefit+the+Most&rft.au=Ashida%2C+Sato%3BHeaney%2C+Catherine+A&rft.aulast=Ashida&rft.aufirst=Sato&rft.date=2008-01-01&rft.volume=32&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Activities%2C+Adaptation+and+Aging&rft.issn=01924788&rft_id=info:doi/10.1080%2F01924780802039261 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-11-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AADADK N1 - SubjectsTermNotLitGenreText - Social networks; Elderly people; Social activities; Social support; Connectedness; Proximity DO - http://dx.doi.org/10.1080/01924780802039261 ER - TY - JOUR T1 - Fear Conditioning in Adolescents With Anxiety Disorders: Results From a Novel Experimental Paradigm AN - 57253845; 200814403 AB - Objective: Considerable research examines fear conditioning in adult anxiety disorders but few studies examine youths. Adult data suggest that anxiety disorders involve elevated fear but intact differential conditioning. We used a novel paradigm to assess fear conditioning in pediatric anxiety patients. Method: Sixteen individuals with anxiety disorders and 38 healthy comparisons viewed two photographs of actresses displaying neutral expressions. One picture served as the conditioned stimulus (CS), paired with a fearful expression and a shrieking scream (CS+), whereas the other picture served as a CS unpaired with the aversive outcome (CS-). Conditioning was indexed by self-reported fear. Subjects participated in two visits involving conditioning and extinction trials. Results: Both groups developed greater fear of the CS+ relative to CS-. Higher fear levels collapsed across each CS characterized anxious relative to healthy subjects, but no significant interaction between group and stimulus type emerged. Fear levels at visit 1 predicted avoidance of visit. Fear levels to both CS types showed stability even after extinction. Conclusions: Consistent with adult data, pediatric anxiety involves higher fear levels following conditioning but not greater differential conditioning. Extending these methods to neuroimaging studies may elucidate neural correlates of fear conditioning. Implications for exposure therapies are discussed. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Lau, Jennifer Y F AU - Lissek, Shmuel AU - Nelson, Eric E AU - Lee, Yoon AU - Roberson-Nay, Roxann AU - Poeth, Kaitlin AU - Jenness, Jessica AU - Ernst, Monique AU - Grillon, Christian AU - Pine, Daniel S AD - National Institute of Mental Health/National Institutes of Health, 15K North Drive, MSC 2670, Bethesda, MD 20892-2670 lauj@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 94 EP - 102 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 1 SN - 0890-8567, 0890-8567 KW - pediatric anxiety disorders, fear conditioning, extinction KW - Paediatrics KW - Anxiety disorders KW - Conditioning KW - Fear KW - Models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Fear+Conditioning+in+Adolescents+With+Anxiety+Disorders%3A+Results+From+a+Novel+Experimental+Paradigm&rft.au=Lau%2C+Jennifer+Y+F%3BLissek%2C+Shmuel%3BNelson%2C+Eric+E%3BLee%2C+Yoon%3BRoberson-Nay%2C+Roxann%3BPoeth%2C+Kaitlin%3BJenness%2C+Jessica%3BErnst%2C+Monique%3BGrillon%2C+Christian%3BPine%2C+Daniel+S&rft.aulast=Lau&rft.aufirst=Jennifer+Y&rft.date=2008-01-01&rft.volume=47&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2Fchi.0b01e31815a5f01 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Fear; Conditioning; Anxiety disorders; Paediatrics; Models DO - http://dx.doi.org/10.1097/chi.0b01e31815a5f01 ER - TY - JOUR T1 - Parental Punitive Discipline, Negative Life Events and Gene- Environment Interplay in the Development of Externalizing Behavior AN - 57249594; 200811135 AB - Background To investigate the extent to which three putative environmental risk factors, maternal punitive discipline (MPD), paternal punitive discipline (PPD) and negative life events (NLEs), share genetic influences with, and moderate the heritability of, externalizing behavior Method: The sample consisted of 2647 participants, aged 12-19 years, from the G1219 and G1219 Twins longitudinal studies. Externalizing behavior was measured using the Youth Self-Report, MPD, PPD and exposure to NLEs were assessed using the Negative Sanctions Scale and the Life Event Scale for Adolescents respectively Result: Genetic influences overlapped for externalizing behavior and each environmental risk, indicating gene-environment correlation. When controlling for the gene-environment correlation, genetic variance decreased, and both shared and non-shared environmental influences increased, as a function of MPD. Genetic variance increased as a function of PPD, and for NLEs the only interaction effect was on the level of non-shared environment influence unique to externalizing behavior Conclusion: The magnitude of the influence of genetic risk on externalizing behavior is contextually dependent, even after controlling for gene-environment correlation. Adapted from the source document. JF - Psychological Medicine AU - Button, T M M AU - Lau, J Y F AU - Maughan, B AU - Eley, T C AD - Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London, UK tanya.button@colorado.edu Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 29 EP - 39 PB - Cambridge University Press, UK VL - 38 IS - 1 SN - 0033-2917, 0033-2917 KW - Genetics KW - Genetic factors KW - Risk factors KW - Environmental aspects KW - Externalizing behaviour KW - Negative life events KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57249594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Parental+Punitive+Discipline%2C+Negative+Life+Events+and+Gene-+Environment+Interplay+in+the+Development+of+Externalizing+Behavior&rft.au=Button%2C+T+M+M%3BLau%2C+J+Y+F%3BMaughan%2C+B%3BEley%2C+T+C&rft.aulast=Button&rft.aufirst=T+M&rft.date=2008-01-01&rft.volume=38&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291707001328 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Externalizing behaviour; Environmental aspects; Risk factors; Genetic factors; Genetics; Negative life events DO - http://dx.doi.org/10.1017/S0033291707001328 ER - TY - JOUR T1 - Clinical Management of Drug Addicts Infected with Human Immunodeficiency Virus and Hepatitis C Virus AN - 57247500; 200816207 AB - Substance abuse and infections remain two of the major problems in the world today. Both are associated with serious morbidity and mortality, including immunological impairment leading to opportunistic infections, mental and neuropsychiatric complications of HIV and HCV infections, and liver damage of chronic HCV infection. Clinical management of substance abusers with infections is possible, available, and effective if individuals in drug treatment programs are closely monitored for adherence and compliance to HIV/HCV treatment regimens. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Addictive Diseases AU - Khalsa, Jag H AU - Vocci, Frank AD - Medical Consequences Branch, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4137, MSC 9551, Bethesda, MD 20892 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1 EP - 10 PB - Haworth Press, Binghamton NY VL - 27 IS - 2 SN - 1055-0887, 1055-0887 KW - Drug addiction, HIV infection, HCV infection, clinical management KW - Hepatitis C KW - HIV KW - Treatment KW - Substance abuse KW - Morbidity-Mortality KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57247500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Clinical+Management+of+Drug+Addicts+Infected+with+Human+Immunodeficiency+Virus+and+Hepatitis+C+Virus&rft.au=Khalsa%2C+Jag+H%3BVocci%2C+Frank&rft.aulast=Khalsa&rft.aufirst=Jag&rft.date=2008-01-01&rft.volume=27&rft.issue=2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/10.1300%2FJ069v27n02_01 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDER N1 - SubjectsTermNotLitGenreText - Substance abuse; HIV; Morbidity-Mortality; Hepatitis C; Treatment DO - http://dx.doi.org/10.1300/J069v27n02_01 ER - TY - JOUR T1 - The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of new psychiatric diagnostic modules and risk factors in a general population sample AN - 57229447; 200812587 AB - This study presents test-retest reliability statistics and information on internal consistency for new diagnostic modules and risk factors for alcohol, drug, and psychiatric disorders from the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV). Test-retest statistics were derived from a random sample of 1899 adults selected from 34,653 respondents who participated in the 2004-2005 Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Internal consistency of continuous scales was assessed using the entire Wave 2 NESARC. Both test and retest interviews were conducted face-to-face. Test-retest and internal consistency results for diagnoses and symptom scales associated with posttraumatic stress disorder, attention-deficit/hyperactivity disorder, and borderline, narcissistic, and schizotypal personality disorders were predominantly good (kappa>0.63; ICC>0.69; alpha>0.75) and reliability for risk factor measures fell within the good to excellent range (intraclass correlations=0.50-0.94; alpha=0.64-0.90). The high degree of reliability found in this study suggests that new AUDADIS-IV diagnostic measures can be useful tools in research settings. The availability of highly reliable measures of risk factors for alcohol, drug, and psychiatric disorders will contribute to the validity of conclusions drawn from future research in the domains of substance use disorder and psychiatric epidemiology. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ruan, W June AU - Goldstein, Rise B AU - Chou, S Patricia AU - Smith, Sharon M AU - Saha, Tulshi D AU - Pickering, Roger P AU - Dawson, Deborah A AU - Huang, Boji AU - Stinson, Frederick S AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, United States Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 27 EP - 36 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 92 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Reliability KW - Alcohol and drug use disorders KW - Risk factors KW - Test-retest reliability KW - General population KW - Internal consistency KW - Diagnostic testing KW - Test-Retest reliability KW - Psychiatric disorders KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57229447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=The+Alcohol+Use+Disorder+and+Associated+Disabilities+Interview+Schedule-IV+%28AUDADIS-IV%29%3A+Reliability+of+new+psychiatric+diagnostic+modules+and+risk+factors+in+a+general+population+sample&rft.au=Ruan%2C+W+June%3BGoldstein%2C+Rise+B%3BChou%2C+S+Patricia%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D%3BPickering%2C+Roger+P%3BDawson%2C+Deborah+A%3BHuang%2C+Boji%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Ruan&rft.aufirst=W&rft.date=2008-01-01&rft.volume=92&rft.issue=1-3&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.06.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Diagnostic testing; Reliability; Psychiatric disorders; Alcohol related disorders; Risk factors; Test-Retest reliability DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.06.001 ER - TY - JOUR T1 - Epidemiologic studies of drinking water contaminants AN - 50614648; 2008-111857 JF - Scientific Investigations Report AU - Cantor, Kenneth P A2 - Buxton, Herbert T. A2 - Griffin, Dale W. A2 - Pierce, Brenda S. Y1 - 2008 PY - 2008 DA - 2008 SP - 17 PB - U. S. Geological Survey, Reston, VA KW - Far East KW - pollutants KW - water management KW - pollution KW - epidemiology KW - decision-making KW - bioavailability KW - drinking water KW - nutrients KW - carcinogens KW - Qaidam Basin KW - metals KW - risk assessment KW - Asia KW - water pollution KW - USGS KW - China KW - public health KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50614648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+Investigations+Report&rft.atitle=Epidemiologic+studies+of+drinking+water+contaminants&rft.au=Cantor%2C+Kenneth+P&rft.aulast=Cantor&rft.aufirst=Kenneth&rft.date=2008-01-01&rft.volume=&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Scientific+Investigations+Report&rft.issn=&rft_id=info:doi/ L2 - http://pubs.usgs.gov/sir/2008/5022/ http://pubs.usgs.gov/sir/ LA - English DB - GeoRef N1 - Conference title - Second national conference on USGS health-related research N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - PubXState - VA N1 - SuppNotes - Accessed on July 1, 2008 N1 - Last updated - 2012-06-07 N1 - CODEN - #06439 N1 - SubjectsTermNotLitGenreText - Asia; bioavailability; carcinogens; China; decision-making; drinking water; epidemiology; Far East; metals; nutrients; pollutants; pollution; public health; Qaidam Basin; risk assessment; USGS; water management; water pollution ER - TY - JOUR T1 - Strengthening resilience within families in addiction treatment AN - 37276768; 3933926 AB - This article is an attempt to present a framework with specific methods that need to be included in addiction treatment by mental health professionals, besides providing a basis for further discussion to strengthen key processes for resilience, making alcoholic families, especially children, more resourceful in handling crises, and at the same time equipping them to meet future challenges. Reprinted with the permission of the TATA Institute of Social Sciences, India JF - Indian journal of social work AU - Sankaran, Lakshmi AU - Muralidhar, D AU - Benegal, Vivek AD - National Institute of Mental Health and Neuro Sciences, Bengaluru Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 45 EP - 53 VL - 69 IS - 1 SN - 0019-5634, 0019-5634 KW - Sociology KW - Alcoholism KW - Social work KW - Family KW - Medical treatment KW - Addiction KW - Parents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37276768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+social+work&rft.atitle=Strengthening+resilience+within+families+in+addiction+treatment&rft.au=Sankaran%2C+Lakshmi%3BMuralidhar%2C+D%3BBenegal%2C+Vivek&rft.aulast=Sankaran&rft.aufirst=Lakshmi&rft.date=2008-01-01&rft.volume=69&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+social+work&rft.issn=00195634&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 561 6220; 4748; 913 561 6220; 9184; 7890 5792 10484; 11950 ER - TY - JOUR T1 - Empirical-likelihood-based difference-in-differences estimators AN - 36846553; 3527467 AB - Recently there has been a surge in econometric and epidemiologic works focusing on estimating average treatment effects under various sets of assumptions. Estimation of average treatment effects in observational studies often requires adjustment for differences in pretreatment variables. Rosenbaum and Rubin have proposed the propensity score method for estimating the average treatment effect by adjusting pretreatment variables. In this paper, the empirical likelihood method is used to estimate average treatment effects on the treated under the difference-in-differences framework. The advantage of this approach is that the common marginal covariate information can be incorporated naturally to enhance the estimation of average treatment effects. Compared with other approaches in the literature, the method proposed can provide more efficient estimation. A simulation study and a real economic data analysis are presented. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Qin, J AU - Zhang, B AD - US National Institute of Allergy and Infectious Diseases ; University of Toledo Y1 - 2008 PY - 2008 DA - 2008 SP - 329 EP - 350 VL - 70 IS - 2 SN - 1369-7412, 1369-7412 KW - Sociology KW - Probability KW - Statistical models KW - Bootstrap mechanism KW - Estimation KW - Sampling KW - Statistical methods KW - Bias UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36846553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Empirical-likelihood-based+difference-in-differences+estimators&rft.au=Qin%2C+J%3BZhang%2C+B&rft.aulast=Qin&rft.aufirst=J&rft.date=2008-01-01&rft.volume=70&rft.issue=2&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12230 8163; 4403 7854; 10214 12224 971; 11255 12228 10919; 1565 1362 2688 2449 10404; 1708 11255 12228 10919 ER - TY - JOUR T1 - A comprehensive analysis of breast cancer news coverage in leading media outlets focusing on environmental risks and prevention AN - 36820818; 3501642 AB - Breast cancer has a high profile in the news media, which are a major source of information for cancer patients and the general public. To determine the nature of breast cancer news coverage available to audiences, particularly on the topics of environmental risks and prevention, this content analysis measured a broad array of dimensions in 231 stories appearing in nine leading newspapers, newsmagazines, and television networks in 2003 and 2004. One fourth of all stories reported on various risks such as hormone replacement therapy (HRT) use. Very few items specifically addressed risks related to controllable lifestyle practices such as prepubertal obesity or chemical contaminants in the environment. About one third of the stories included prevention content, primarily focusing narrowly on use of pharmaceutical products. Little information described risk reduction via other individual preventive behaviors (e.g., diet, exercise, and smoking), parental protective measures, or collective actions to combat contamination sites. The more traditional categories of prevalence, detection, and treatment were featured in one third, one quarter, and two fifths of the news items, respectively. There were twice as many stories featuring personal narratives as statistical figures, and two thirds of all the news items cited expert medical professionals, researchers, or organizations. Implications of these findings and directions for future research are addressed. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Atkin, Charles AU - Smith, Sandi AU - McFeters, Courtnay AU - Ferguson, Vanessa AD - Michigan State University ; National Cancer Institute, USA ; Eastern Michigan University Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 3 EP - 19 VL - 13 IS - 1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Breast cancer KW - Risk KW - Prevention KW - Media KW - Information services KW - News KW - Cancer KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36820818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=A+comprehensive+analysis+of+breast+cancer+news+coverage+in+leading+media+outlets+focusing+on+environmental+risks+and+prevention&rft.au=Atkin%2C+Charles%3BSmith%2C+Sandi%3BMcFeters%2C+Courtnay%3BFerguson%2C+Vanessa&rft.aulast=Atkin&rft.aufirst=Charles&rft.date=2008-01-01&rft.volume=13&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730701806912 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 7862 2572; 6532 6515; 11035; 10072; 8669 6515; 10449 5772 DO - http://dx.doi.org/10.1080/10810730701806912 ER - TY - JOUR T1 - Risk perceptions and worry about cancer: does gender make a difference? AN - 36820587; 3501645 AB - Risk perceptions and worry are important constructs in many theoretical frameworks used to develop cancer screening interventions. Because most cancers for which we have early detection or prevention strategies are gender specific, few investigations have examined gender differences. We examined gender differences in the magnitude of, and associations with, perceived risk and worry by cancer type. Our sample included 939 men and 1,580 women > 50 years old with no history of relevant cancers from the 2003 Health Information National Trends Survey (HINTS). Dependent variables included absolute and comparative perceived risk and worry for gender-specific (breast/prostate) and colon cancers. We examined demographics, health status, health behaviors, cancer beliefs, and cancer communication variables as correlates. Linear regression analyses and pairwise contrasts were conducted with SUDAAN. Men reported greater comparative perceived risk for developing cancers, whereas women reported more frequent cancer worry. For both genders, perceived risk and worry were lowest for colon cancer. Correlates of perceived risk and worry varied, and several associations were moderated by gender. Different risk messages and intervention strategies may be needed to influence males' and females' perceived cancer risk and worry. All effect sizes were small, and future prospective research is needed to confirm our findings. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - McQueen, Amy AU - Vernon, Sally AU - Meissner, Helen AU - Rakowski, William AD - University of Texas, Houston ; National Cancer Institute, USA ; Brown University Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 56 EP - 79 VL - 13 IS - 1 SN - 1081-0730, 1081-0730 KW - Sociology KW - Risk KW - Prevention KW - Perception KW - Health education KW - Gender KW - Information dissemination KW - Cancer KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36820587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Risk+perceptions+and+worry+about+cancer%3A+does+gender+make+a+difference%3F&rft.au=McQueen%2C+Amy%3BVernon%2C+Sally%3BMeissner%2C+Helen%3BRakowski%2C+William&rft.aulast=McQueen&rft.aufirst=Amy&rft.date=2008-01-01&rft.volume=13&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730701807076 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 11035; 9382; 5421 6091; 10449 5772; 10072; 5779 4049; 6520 DO - http://dx.doi.org/10.1080/10810730701807076 ER - TY - JOUR T1 - Structure-based design of anticancer prodrug PABA/NO AN - 21443854; 11862447 AB - Glutathione S-transferase (GST) is a superfamily of detoxification enzymes, represented by GSTI-, GSTI14, GSTI, etc. GSTI- is the predominant isoform of GST in human liver, playing important roles for our well being. GSTI is overexpressed in many forms of cancer, thus presenting an opportunity for selective targeting of cancer cells. Our structure-based design of prodrugs intended to release cytotoxic levels of nitric oxide in GSTI-overexpressing cancer cells yielded PABA/NO, which exhibited anticancer activity both in vitro and in vivo with a potency similar to that of cisplatin. Here, we present the details on structural modification, molecular modeling, and enzymatic characterization for the design of PABA/NO. The design was efficient because it was on the basis of the reaction mechanism and the structures of related GST isozymes at both the ground state and the transition state. The ground-state structures outlined the shape and property of the substrate-binding site in different isozymes, and the structural information at the transition-state indicated distinct conformations of the Meisenheimer complex of prodrugs in the active site of different isozymes, providing guidance for the modifications of the molecular structure of the prodrug molecules. Two key alterations of a GSTI--selective compound led to the GSTI-selective PABA/NO. JF - Drug Design, Development and Therapy AU - Ji, Xinhua AU - Pal, Ajai AU - Kalathur, Ravi AU - Hu, Xun AU - Gu, Yijun AU - Saavedra, Joseph E AU - Buzard, Gregory S AU - Srinivasan, Aloka AU - Keefer, Larry K AU - Singh, Shivendra V AD - Macromolecular Crystallography Laboratory, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 123 EP - 130 VL - 2 KW - Biotechnology and Bioengineering Abstracts KW - structure-based KW - drug design KW - anticancer KW - prodrug KW - PABA/NO KW - Detoxification KW - Molecular modelling KW - Enzymes KW - Drug development KW - Glutathione transferase KW - Cancer KW - Cytotoxicity KW - Reaction mechanisms KW - prodrugs KW - Cisplatin KW - Liver KW - Isoenzymes KW - Nitric oxide KW - Conformation KW - Antitumor activity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21443854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Design%2C+Development+and+Therapy&rft.atitle=Structure-based+design+of+anticancer+prodrug+PABA%2FNO&rft.au=Ji%2C+Xinhua%3BPal%2C+Ajai%3BKalathur%2C+Ravi%3BHu%2C+Xun%3BGu%2C+Yijun%3BSaavedra%2C+Joseph+E%3BBuzard%2C+Gregory+S%3BSrinivasan%2C+Aloka%3BKeefer%2C+Larry+K%3BSingh%2C+Shivendra+V&rft.aulast=Ji&rft.aufirst=Xinhua&rft.date=2008-01-01&rft.volume=2&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Drug+Design%2C+Development+and+Therapy&rft.issn=1177-8881&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Detoxification; Molecular modelling; Enzymes; Drug development; Glutathione transferase; Cancer; Reaction mechanisms; Cytotoxicity; Cisplatin; prodrugs; Isoenzymes; Liver; Nitric oxide; Antitumor activity; Conformation ER - TY - JOUR T1 - Gene Therapy: Some History, Applications, Problems, and Prospects AN - 21324631; 12508128 AB - The concept of transferring genes to tissues for clinical applications has been discussed for nearly half a century, but our ability to manipulate genetic material via recombinant DNA technology has brought this goal to reality. While originally conceived as a way to treat life-threatening disorders (inborn errors, cancers) refractory to conventional treatment, gene therapy now is considered for many non-life-threatening conditions, including those adversely affecting a patient's quality of life. The lack of suitable treatment has become a rational basis for extending the scope of gene therapy. This manuscript reviews the general methods by which genes are transferred as well as diverse examples of clinical applications (acquired tissue damage, upper gastrointestinal tract infection, autoimmune disease, systemic protein deficiency). Despite some well-publicized problems, gene therapy has made substantive progress, including tangible success, albeit much slower than was initially predicted. Although gene therapy is still at a fairly primitive stage, it is firmly science based. There is justifiable optimism that with increased pathobiological understanding and biotechnological improvements, gene therapy will become a standard part of clinical practice within 20 years. JF - Toxicologic Pathology AU - Cotrim, Ana P AU - Baum, Bruce J AD - National Institute of Dental and Craniofacial Research, NIH, DHHS, Bethesda, Maryland, USA, acotrim@nidcr.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 97 EP - 103 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 1 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Salivary gland KW - animal models KW - cell(ular) pathology. KW - Gene therapy KW - Protein deficiency KW - Autoimmune diseases KW - DNA KW - Therapeutic applications KW - Gastrointestinal tract KW - Infection KW - Cancer KW - Quality of life KW - G 07720:Immunogenetics KW - W 30905:Medical Applications KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21324631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Gene+Therapy%3A+Some+History%2C+Applications%2C+Problems%2C+and+Prospects&rft.au=Cotrim%2C+Ana+P%3BBaum%2C+Bruce+J&rft.aulast=Cotrim&rft.aufirst=Ana&rft.date=2008-01-01&rft.volume=36&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623307309925 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Gene therapy; Autoimmune diseases; Protein deficiency; DNA; Therapeutic applications; Gastrointestinal tract; Infection; Cancer; Quality of life DO - http://dx.doi.org/10.1177/0192623307309925 ER - TY - JOUR T1 - An Approach to Achieve Long-Term Expression in Skin Gene Therapy AN - 21295949; 12508144 AB - For gene therapy purposes, the skin is an attractive organ to target for systemic delivery of therapeutic proteins to treat systemic diseases, skin diseases, or skin cancer. To achieve long-term stable expression of a therapeutic gene in keratinocytes (KC), we have developed an approach using a bicistronic retroviral vector expressing the desired therapeutic gene linked to a selectable marker (multidrug resistant gene, MDR) that is then introduced into KC and fibroblasts (FB) to create genetically modified human skin equivalent (HSE). After grafting the HSE onto immunocompromised mice, topical colchicine treatment is used to select and enrich for genetically modified keratinocyte stem cells (KSC) that express MDR and are resistant to colchicine's antimitotic effects. Both the apparatus for topical colchicine delivery and the colchicine doses have been optimized for application to human skin. This approach can be validated by systemic delivery of therapeutic factors such as erythropoietin and the antihypertensive atrial natriuretic peptide. JF - Toxicologic Pathology AU - Therrien, Jean-Philippe AU - Pfuetzner, Wolfgang AU - Vogel, Jonathan C AD - Dermatology Branch, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA, therriej@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 104 EP - 111 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 1 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Human skin KW - gene therapy KW - multidrug resistance gene KW - bicistronic retroviral vectors KW - systemic delivery KW - topical selection. KW - Grafting KW - Gene therapy KW - Atrial natriuretic peptide KW - Skin cancer KW - Fibroblasts KW - Expression vectors KW - Antihypertensives KW - Stem cells KW - Erythropoietin KW - Skin diseases KW - Multidrug resistance KW - Colchicine KW - Keratinocytes KW - G 07720:Immunogenetics KW - W 30905:Medical Applications KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21295949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=An+Approach+to+Achieve+Long-Term+Expression+in+Skin+Gene+Therapy&rft.au=Therrien%2C+Jean-Philippe%3BPfuetzner%2C+Wolfgang%3BVogel%2C+Jonathan+C&rft.aulast=Therrien&rft.aufirst=Jean-Philippe&rft.date=2008-01-01&rft.volume=36&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623307312705 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Gene therapy; Grafting; Atrial natriuretic peptide; Skin cancer; Fibroblasts; Expression vectors; Stem cells; Antihypertensives; Skin diseases; Erythropoietin; Colchicine; Multidrug resistance; Keratinocytes DO - http://dx.doi.org/10.1177/0192623307312705 ER - TY - JOUR T1 - Chlamydia psittaci-eradicating antibiotic therapy in patients with advanced-stage ocular adnexal MALT lymphoma AN - 21124929; 7932758 JF - Annals of Oncology AU - Ferreri, AJM AU - Dognini, G P AU - Ponzoni, M AU - Pecciarini, L AU - Cangi, M G AU - Santambrogio, G AU - Resti, A G AU - De Conciliis, C AU - Magnino, S AU - Pasini, E AU - Vicari, N AU - Dolcetti, R AU - Doglioni, C AD - Unit of Lymphoid Malignancies. Medical Oncology Unit, Department of Oncology. Pathology Unit. Ophthalmology Unit, San Raffaele Scientific Institute, Milan. Ophthalmology Unit, Ospedale San Giuseppe, Milan. National Reference Laboratory for Chlamydioses, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Pavia. Cancer Bio-Immunotherapy Unit, Deptartment of Medical Oncology, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 194 EP - 195 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 19 IS - 1 SN - 0923-7534, 0923-7534 KW - Microbiology Abstracts B: Bacteriology KW - Antibiotics KW - Mucosal-associated lymphoid tissue KW - Lymphoma KW - Chlamydia KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21124929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Oncology&rft.atitle=Chlamydia+psittaci-eradicating+antibiotic+therapy+in+patients+with+advanced-stage+ocular+adnexal+MALT+lymphoma&rft.au=Ferreri%2C+AJM%3BDognini%2C+G+P%3BPonzoni%2C+M%3BPecciarini%2C+L%3BCangi%2C+M+G%3BSantambrogio%2C+G%3BResti%2C+A+G%3BDe+Conciliis%2C+C%3BMagnino%2C+S%3BPasini%2C+E%3BVicari%2C+N%3BDolcetti%2C+R%3BDoglioni%2C+C&rft.aulast=Ferreri&rft.aufirst=AJM&rft.date=2008-01-01&rft.volume=19&rft.issue=1&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Annals+of+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Antibiotics; Mucosal-associated lymphoid tissue; Lymphoma; Chlamydia ER - TY - JOUR T1 - Genomic studies to explore self-renewal and differentiation properties of embryonic stem cells AN - 21105008; 11139618 AB - Embryonic stem cells (ESCs) are pluripotent cells with an indefinite replication potential and an ability to differentiate into a variety of cell lineages, holding a great promise for regenerative medicine and biological research. The genome and transcriptome of ESCs have been extensively examined in order to decipher their self-renewal and differentiation mechanisms. Global transcriptional profiling allows the identification of genes expressed differentially or uniquely in ESCs and the elucidation of the molecular signatures. Comparative genomics and transcriptomics help to explore evolutionary conserved and divergent transcriptional patterns and functional landscape of ESCs, and identify fundamental and species-specific mechanisms controlling the pluripotency. Chromosomal mapping of the transcriptome demonstrates the coexpression of neighboring genes along the chromosome and highlights their dynamic changes in response to ESC differentiation. Epigenetic analysis reveals methylation patterns and microRNA profiles unique to ESCs. In this article, various aspects of genomic and transcriptomic studies on ESCs are reviewed, and important findings regarding ESC self-renewal and differentiation are highlighted and discussed. JF - Frontiers in Bioscience AU - Zhan, M AD - Bioinformatics Unit, Research Resources Branch, National Institute on Aging, NIH, Baltimore, MD, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 276 EP - 283 VL - 13 SN - 1093-9946, 1093-9946 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Cell lineage KW - Evolutionary conservation KW - Replication KW - Landscape KW - miRNA KW - Transcription KW - Gene expression KW - Differentiation KW - Chromosomes KW - Stem cells KW - Embryo cells KW - epigenetics KW - Reviews KW - Regeneration KW - genomics KW - Gene mapping KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21105008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=Genomic+studies+to+explore+self-renewal+and+differentiation+properties+of+embryonic+stem+cells&rft.au=Zhan%2C+M&rft.aulast=Zhan&rft.aufirst=M&rft.date=2008-01-01&rft.volume=13&rft.issue=&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Bioscience&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Cell lineage; Evolutionary conservation; Replication; miRNA; Landscape; Transcription; Gene expression; Differentiation; Stem cells; Chromosomes; Embryo cells; epigenetics; Reviews; Regeneration; genomics; Gene mapping ER - TY - JOUR T1 - Rationally-designed vaccine adjuvants: separating efficacy from toxicity AN - 21097156; 11139818 AB - Adjuvants, substances included in many vaccines in order to improve immune responses, are challenging to develop and license because adjuvant compounds that stimulate strong protective immunity also frequently induce significant toxicity. Adjuvant design and development has until recently been largely empirical; but with the current knowledge that most adjuvants act via receptors of the innate immune system, molecular-based approaches are rapidly advancing the field. Data support the concept that proinflammatory pathways induced by innate immune receptor triggering underlie many of the observed toxic effects. Importantly, the cellular signaling pathways that lead to inflammation are known, for a number of innate immune receptors, to be distinct from those that are involved in the costimulation of protective adaptive immune responses, leading to approaches for attenuating inflammatory signaling that should lead to safer and more effective vaccine adjuvants. This article addresses whether there is a clear rationale for the separation of toxicity from efficacy in the function of adjuvants based upon innate immune receptor ligands. JF - Frontiers in Bioscience AU - Hauguel, T M AU - Hackett, C J AD - Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 2806 EP - 2813 VL - 13 SN - 1093-9946, 1093-9946 KW - Toxicology Abstracts; Immunology Abstracts KW - Data processing KW - Receptor mechanisms KW - Immune system KW - Adjuvants KW - Toxicity KW - Vaccines KW - Immune response KW - Immunity KW - Inflammation KW - Signal transduction KW - X 24310:Pharmaceuticals KW - F 06905:Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21097156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=Rationally-designed+vaccine+adjuvants%3A+separating+efficacy+from+toxicity&rft.au=Hauguel%2C+T+M%3BHackett%2C+C+J&rft.aulast=Hauguel&rft.aufirst=T&rft.date=2008-01-01&rft.volume=13&rft.issue=&rft.spage=2806&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Bioscience&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Receptor mechanisms; Immune system; Immunity; Immune response; Vaccines; Toxicity; Adjuvants; Signal transduction; Inflammation ER - TY - JOUR T1 - The Role of Cellular Accumulation in Determining Sensitivity to Platinum- Based Chemotherapy AN - 21061243; 8190481 AB - The platinum (Pt) drugs cisplatin and carboplatin are heavily employed in chemotherapy regimens; however, similar to other classes of drugs, a number of intrinsic and acquired resistance mechanisms hamper their effectiveness. The method by which Pt drugs enter cells has traditionally been attributed to simple passive diffusion. However, recent evidence suggests a number of active uptake and efflux mechanisms are at play, and altered regulation of these transporters is responsible for the reduced accumulation of drug in resistant cells. This review suggests a model that helps reconcile the disparate literature by describing multiple pathways for Pt-containing drugs into and out of the cell. JF - Annual Review of Pharmacology and Toxicology AU - Hall, Matthew D AU - Okabe, Mitsunori AU - Shen, Ding-Wu AU - Liang, Xing-Jie AU - Gottesman, Michael M AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, mgottesman@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 495 EP - 535 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 48 SN - 0362-1642, 0362-1642 KW - Toxicology Abstracts KW - Play KW - Cisplatin KW - Chemotherapy KW - Reviews KW - Platinum KW - Diffusion KW - Carboplatin KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21061243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Pharmacology+and+Toxicology&rft.atitle=The+Role+of+Cellular+Accumulation+in+Determining+Sensitivity+to+Platinum-+Based+Chemotherapy&rft.au=Hall%2C+Matthew+D%3BOkabe%2C+Mitsunori%3BShen%2C+Ding-Wu%3BLiang%2C+Xing-Jie%3BGottesman%2C+Michael+M&rft.aulast=Hall&rft.aufirst=Matthew&rft.date=2008-01-01&rft.volume=48&rft.issue=&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Pharmacology+and+Toxicology&rft.issn=03621642&rft_id=info:doi/10.1146%2Fannurev.pharmtox.48.080907.180426 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Play; Cisplatin; Reviews; Chemotherapy; Platinum; Diffusion; Carboplatin; Drugs DO - http://dx.doi.org/10.1146/annurev.pharmtox.48.080907.180426 ER - TY - JOUR T1 - B-MYB Is Essential for Normal Cell Cycle Progression and Chromosomal Stability of Embryonic Stem Cells AN - 21060635; 8523591 AB - Background The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. This lethal phenotype has generally been attributed to a proliferation defect in the cell cycle phase of G1. Methodology/Principal Findings In the present study, we show that the major cell cycle defect in murine embryonic stem (mES) cells occurs in G2/M. Specifically, knockdown of B-Myb by short-hairpin RNAs results in delayed transit through G2/M, severe mitotic spindle and centrosome defects, and in polyploidy. Moreover, many euploid mES cells that are transiently deficient in B-Myb become aneuploid and can no longer be considered viable. Knockdown of B-Myb in mES cells also decreases Oct4 RNA and protein abundance, while over-expression of B-MYB modestly up-regulates pou5f1 gene expression. The coordinated changes in B-Myb and Oct4 expression are due, at least partly, to the ability of B-Myb to directly modulate pou5f1 gene promoter activity in vitro. Ultimately, the loss of B-Myb and associated loss of Oct4 lead to an increase in early markers of differentiation prior to the activation of caspase-mediated programmed cell death. Conclusions/Significance Appropriate B-Myb expression is critical to the maintenance of chromosomally stable and pluripotent ES cells, but its absence promotes chromosomal instability that results in either aneuploidy or differentiation-associated cell death. JF - PLoS ONE AU - Tarasov, Kirill V AU - Tarasova, Yelena S AU - Tam, Wai Leong AU - Riordon, Daniel R AU - Elliott, Steven T AU - Kania, Gabriela AU - Li, Jinliang AU - Yamanaka, Satoshi AU - Crider, David G AU - Testa, Gianluca AU - Li, Ronald A AU - Lim, Bing AU - Stewart, Colin L AU - Liu, Yie AU - Van Eyk, Jennifer E AU - Wersto, Robert P AU - Wobus, Anna M AU - Boheler, Kenneth R AU - Zwaka, Thomas AD - Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America Y1 - 2008 PY - 2008 DA - 2008 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 3 IS - 6 SN - 1932-6203, 1932-6203 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Aneuploidy KW - Apoptosis KW - Polyploidy KW - Cell cycle KW - Gene expression KW - MYB protein KW - Promoters KW - Differentiation KW - Stem cells KW - Cell death KW - Spindles KW - Genomic instability KW - Embryo cells KW - RNA KW - Centrosomes KW - Transcription factors KW - Overexpression KW - Cell proliferation KW - Oct-4 protein KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21060635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=B-MYB+Is+Essential+for+Normal+Cell+Cycle+Progression+and+Chromosomal+Stability+of+Embryonic+Stem+Cells&rft.au=Tarasov%2C+Kirill+V%3BTarasova%2C+Yelena+S%3BTam%2C+Wai+Leong%3BRiordon%2C+Daniel+R%3BElliott%2C+Steven+T%3BKania%2C+Gabriela%3BLi%2C+Jinliang%3BYamanaka%2C+Satoshi%3BCrider%2C+David+G%3BTesta%2C+Gianluca%3BLi%2C+Ronald+A%3BLim%2C+Bing%3BStewart%2C+Colin+L%3BLiu%2C+Yie%3BVan+Eyk%2C+Jennifer+E%3BWersto%2C+Robert+P%3BWobus%2C+Anna+M%3BBoheler%2C+Kenneth+R%3BZwaka%2C+Thomas&rft.aulast=Tarasov&rft.aufirst=Kirill&rft.date=2008-01-01&rft.volume=3&rft.issue=6&rft.spage=e2478&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0002478 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Polyploidy; Apoptosis; Aneuploidy; Cell cycle; MYB protein; Gene expression; Differentiation; Promoters; Spindles; Cell death; Stem cells; Genomic instability; RNA; Embryo cells; Overexpression; Transcription factors; Centrosomes; Oct-4 protein; Cell proliferation DO - http://dx.doi.org/10.1371/journal.pone.0002478 ER - TY - JOUR T1 - Conserved and Differential Effects of Dietary Energy Intake on the Hippocampal Transcriptomes of Females and Males AN - 21057357; 8521752 AB - The level of dietary energy intake influences metabolism, reproductive function, the development of age-related diseases, and even cognitive behavior. Because males and females typically play different roles in the acquisition and allocation of energy resources, we reasoned that dietary energy intake might differentially affect the brains of males and females at the molecular level. To test this hypothesis, we performed a gene array analysis of the hippocampus in male and female rats that had been maintained for 6 months on either ad libitum (control), 20% caloric restriction (CR), 40% CR, intermittent fasting (IF) or high fat/high glucose (HFG) diets. These diets resulted in expected changes in body weight, and circulating levels of glucose, insulin and leptin. However, the CR diets significantly increased the size of the hippocampus of females, but not males. Multiple genes were regulated coherently in response to energy restriction diets in females, but not in males. Functional physiological pathway analyses showed that the 20% CR diet down-regulated genes involved in glycolysis and mitochondrial ATP production in males, whereas these metabolic pathways were up-regulated in females. The 40% CR diet up-regulated genes involved in glycolysis, protein deacetylation, PGC-1 alpha and mTor pathways in both sexes. IF down-regulated many genes in males including those involved in protein degradation and apoptosis, but up-regulated many genes in females including those involved in cellular energy metabolism, cell cycle regulation and protein deacetylation. Genes involved in energy metabolism, oxidative stress responses and cell death were affected by the HFG diet in both males and females. The gender-specific molecular genetic responses of hippocampal cells to variations in dietary energy intake identified in this study may mediate differential behavioral responses of males and females to differences in energy availability. JF - PLoS ONE AU - Martin, Bronwen AU - Pearson, Michele AU - Brenneman, Randall AU - Golden, Erin AU - Keselman, Alex AU - Iyun, Titilola AU - Carlson, Olga D AU - Egan, Josephine M AU - Becker, Kevin G AU - Wood, William AU - Prabhu, Vinayakumar AU - de Cabo, Rafael AU - Maudsley, Stuart AU - Mattson, Mark P AU - Mayeux, Richard AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America Y1 - 2008 PY - 2008 DA - 2008 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 3 IS - 6 SN - 1932-6203, 1932-6203 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Apoptosis KW - Hippocampus KW - Cell cycle KW - Energy intake KW - Glucose KW - Mitochondria KW - Fasting KW - Deacetylation KW - Sex differences KW - Insulin KW - Gene expression KW - Body weight KW - Oxidative stress KW - Metabolic pathways KW - PGC-1 protein KW - Energy metabolism KW - Dietary restrictions KW - Brain KW - ATP KW - Leptin KW - High fat diet KW - Cognitive ability KW - Energy resources KW - Glycolysis KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21057357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Conserved+and+Differential+Effects+of+Dietary+Energy+Intake+on+the+Hippocampal+Transcriptomes+of+Females+and+Males&rft.au=Martin%2C+Bronwen%3BPearson%2C+Michele%3BBrenneman%2C+Randall%3BGolden%2C+Erin%3BKeselman%2C+Alex%3BIyun%2C+Titilola%3BCarlson%2C+Olga+D%3BEgan%2C+Josephine+M%3BBecker%2C+Kevin+G%3BWood%2C+William%3BPrabhu%2C+Vinayakumar%3Bde+Cabo%2C+Rafael%3BMaudsley%2C+Stuart%3BMattson%2C+Mark+P%3BMayeux%2C+Richard&rft.aulast=Martin&rft.aufirst=Bronwen&rft.date=2008-01-01&rft.volume=3&rft.issue=6&rft.spage=e2398&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0002398 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Apoptosis; Hippocampus; Cell cycle; Glucose; Energy intake; Mitochondria; Deacetylation; Fasting; Sex differences; Insulin; Gene expression; Body weight; Oxidative stress; Metabolic pathways; PGC-1 protein; Energy metabolism; Dietary restrictions; Brain; ATP; Leptin; High fat diet; Cognitive ability; Energy resources; Glycolysis DO - http://dx.doi.org/10.1371/journal.pone.0002398 ER - TY - JOUR T1 - Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth AN - 21053663; 8517135 AB - MicroRNAs (miRNAs) play important roles in cancer development. By cloning and sequencing of a HPV16 super(+) CaSki cell small RNA library, we isolated 174 miRNAs (including the novel miR-193c) which could be grouped into 46 different miRNA species, with miR-21, miR-24, miR-27a, and miR-205 being most abundant. We chose for further study 10 miRNAs according to their cloning frequency and associated their levels in 10 cervical cancer- or cervical intraepithelial neoplasia-derived cell lines. No correlation was observed between their expression with the presence or absence of an integrated or episomal HPV genome. All cell lines examined contained no detectable miR-143 and miR-145. HPV-infected cell lines expressed a different set of miRNAs when grown in organotypic raft cultured as compared to monolayer cell culture, including expression of miR-143 and miR-145. This suggests a correlation between miRNA expression and tissue differentiation. Using miRNA array analyses for age-matched normal cervix and cervical cancer tissues, in combination with northern blot verification, we identified significantly deregulated miRNAs in cervical cancer tissues, with miR-126, miR-143, and miR-145 downregulation and miR-15b, miR-16, miR-146a, and miR-155 upregulation. Functional studies showed that both miR-143 and miR-145 are suppressive to cell growth. When introduced into cell lines, miR-146a was found to promote cell proliferation. Collectively, our data indicate that downregulation of miR-143 and miR-145 and upregulation of miR-146a play a role in cervical carcinogenesis. JF - PLoS ONE AU - Wang, Xiaohong AU - Tang, Shuang AU - Le, Shu-Yun AU - Lu, Robert AU - Rader, Janet S AU - Meyers, Craig AU - Zheng, Zhi-Ming AU - Jin, Dong-Yan AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, Nation Cancer Institute (NCI)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America Y1 - 2008 PY - 2008 DA - 2008 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 3 IS - 7 SN - 1932-6203, 1932-6203 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Oncogenes & Growth Factors Abstracts KW - Genomes KW - Differentiation KW - Data processing KW - RNA KW - miRNA KW - Cervical cancer KW - Carcinogenesis KW - Cell culture KW - Cervix KW - Cell proliferation KW - Human papillomavirus KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - N 14830:RNA KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21053663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Aberrant+Expression+of+Oncogenic+and+Tumor-Suppressive+MicroRNAs+in+Cervical+Cancer+Is+Required+for+Cancer+Cell+Growth&rft.au=Wang%2C+Xiaohong%3BTang%2C+Shuang%3BLe%2C+Shu-Yun%3BLu%2C+Robert%3BRader%2C+Janet+S%3BMeyers%2C+Craig%3BZheng%2C+Zhi-Ming%3BJin%2C+Dong-Yan&rft.aulast=Wang&rft.aufirst=Xiaohong&rft.date=2008-01-01&rft.volume=3&rft.issue=7&rft.spage=e2557&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0002557 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Differentiation; Data processing; RNA; Carcinogenesis; Cervical cancer; miRNA; Cell culture; Cell proliferation; Cervix; Human papillomavirus DO - http://dx.doi.org/10.1371/journal.pone.0002557 ER - TY - JOUR T1 - Annular Structures as Intermediates in Fibril Formation of Alzheimer A beta sub(17-42) AN - 21046428; 8236873 AB - We report all-atom molecular dynamics simulations of annular beta -amyloid (17-42) structures, single- and double-layered, in solution. We assess the structural stability and association force of A beta annular oligomers associated through different interfaces, with a mutated sequence (M35A), and with the oxidation state (M35O). Simulation results show that single-layered annular models display inherent structural instability: one is broken down into linear-like oligomers, and the other collapses. On the other hand, a double-layered annular structure where the two layers interact through their C-termini to form an NC-CN interface (where N and C are the N and C termini, respectively) exhibits high structural stability over the simulation time due to strong hydrophobic interactions and geometrical constraints induced by the closed circular shape. The observed dimensions and molecular weight of the oligomers from atomic force microscopy (AFM) experiments are found to correspond well to our stable double-layered model with the NC-CN interface. Comparison with K3 annular structures derived from the beta sub(2)-microglobulin suggests that the driving force for amyloid formation is sequence specific, strongly dependent on side-chain packing arrangements, structural morphologies, sequence composition, and residue positions. Combined with our previous simulations of linear-like A beta , K3 peptide, and sup35-derived GNNQQNY peptide, the annular structures provide useful insight into oligomeric structures and driving forces that are critical in amyloid fibril formation. JF - Journal of Physical Chemistry B AU - Zheng, Jie AU - Ma, Buyong AU - Nussinov, Ruth AU - Jang, Hyunbum AD - Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland 21702 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 6856 EP - 6865 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 112 IS - 22 SN - 1520-6106, 1520-6106 KW - Aqualine Abstracts; CSA Neurosciences Abstracts KW - Molecular modelling KW - Interfaces KW - Alzheimer's disease KW - atomic force microscopy KW - Hydrophobicity KW - Packing KW - Model Studies KW - Models KW - Shape KW - Neurodegenerative diseases KW - Weight KW - Structure KW - Fibrillogenesis KW - Molecular weight KW - Microscopy KW - Morphology KW - Oxidation KW - Peptides KW - beta -Amyloid KW - beta 2-microglobulin KW - AQ 00001:Water Resources and Supplies KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21046428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Physical+Chemistry+B&rft.atitle=Annular+Structures+as+Intermediates+in+Fibril+Formation+of+Alzheimer+A+beta+sub%2817-42%29&rft.au=Zheng%2C+Jie%3BMa%2C+Buyong%3BNussinov%2C+Ruth%3BJang%2C+Hyunbum&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2008-01-01&rft.volume=112&rft.issue=22&rft.spage=6856&rft.isbn=&rft.btitle=&rft.title=Journal+of+Physical+Chemistry+B&rft.issn=15206106&rft_id=info:doi/10.1021%2Fjp711335b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Molecular modelling; Molecular weight; Fibrillogenesis; Oxidation; Alzheimer's disease; atomic force microscopy; Hydrophobicity; Packing; beta -Amyloid; beta 2-microglobulin; Models; Shape; Weight; Interfaces; Structure; Morphology; Microscopy; Peptides; Model Studies DO - http://dx.doi.org/10.1021/jp711335b ER - TY - JOUR T1 - Frequency specificity of functional connectivity in brain networks AN - 21040564; 8569128 AB - Synchronized low-frequency spontaneous fluctuations of the functional MRI (fMRI) signal have been shown to be associated with electroencephalography (EEG) power fluctuations in multiple brain networks within predefined frequency bands. However, it remains unclear whether frequency-specific characteristics exist in the resting-state fMRI signal. In this study, fMRI signals in five functional brain networks (sensorimotor, 'default mode', visual, amygdala, and hippocampus) were decomposed into various frequency bands within a low-frequency range (0-0.24 Hz). Results show that the correlations in cortical networks concentrate within ultra-low frequencies (0.01-0.06 Hz) while connections within limbic networks distribute over a wider frequency range (0.01-0.14 Hz), suggesting distinct frequency-specific features in the resting-state fMRI signal within these functional networks. Moreover, the connectivity decay rates along the frequency bands are positively correlated with the physical distances between connected brain regions and seed points. This distance-frequency relationship might be attributed to a larger attenuation of synchrony of brain regions separated with longer distance and/or connected with more synaptic steps. JF - NeuroImage AU - Wu, Changwei W AU - Gu, Hong AU - Stein, Hanbing Lu Elliot A AU - Chen, Jyh-Horng AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, MD, USA, jhchen@ntu.edu.tw Y1 - 2008 PY - 2008 DA - 2008 SP - 1047 EP - 1055 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 42 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Seeds KW - Hippocampus KW - Neural networks KW - Functional magnetic resonance imaging KW - sensorimotor system KW - Amygdala KW - EEG KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21040564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Frequency+specificity+of+functional+connectivity+in+brain+networks&rft.au=Wu%2C+Changwei+W%3BGu%2C+Hong%3BStein%2C+Hanbing+Lu+Elliot+A%3BChen%2C+Jyh-Horng%3BYang%2C+Yihong&rft.aulast=Wu&rft.aufirst=Changwei&rft.date=2008-01-01&rft.volume=42&rft.issue=3&rft.spage=1047&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.05.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Brain mapping; Neural networks; EEG; sensorimotor system; Amygdala; Seeds; Hippocampus DO - http://dx.doi.org/10.1016/j.neuroimage.2008.05.035 ER - TY - JOUR T1 - Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation AN - 21036769; 8568810 AB - The peripheral benzodiazepine receptor (PBR) is upregulated on activated microglia and macrophages and thereby is a useful biomarker of inflammation. We developed a novel PET radioligand, [ super(11)C]PBR28, that was able to image and quantify PBRs in healthy monkeys and in a rat model of stroke. The objective of this study was to evaluate the ability of [ super(11)C]PBR28 to quantify PBRs in brain of healthy human subjects. Twelve subjects had PET scans of 120 to 180 min duration as well as serial sampling of arterial plasma to measure the concentration of unchanged parent radioligand. One- and two-tissue compartmental analyses were performed. To obtain stable estimates of distribution volume, which is a summation of B sub(max)/K sub(D) and nondisplaceable activity, 90 min of brain imaging was required. Distribution volumes in human were only 5% of those in monkey. This comparatively low amount of receptor binding required a two-rather than a one-compartment model, suggesting that nonspecific binding was a sizeable percentage compared to specific binding. The time-activity curves in two of the twelve subjects appeared as if they had no PBR binding - i.e., rapid peak of uptake and fast washout from brain. The cause(s) of these unusual findings are unknown, but both subjects were also found to lack binding to PBRs in peripheral organs such as lung and kidney. In conclusion, with the exception of those subjects who appeared to have no PBR binding, [ super(11)C]PBR28 is a promising ligand to quantify PBRs and localize inflammation associated with increased densities of PBRs. JF - NeuroImage AU - Fujita, Masahiro AU - Imaizumi, Masao AU - Zoghbi, Sami S AU - Fujimura, Yota AU - Farris, Amanda G AU - Suhara, Tetsuya AU - Hong, Jinsoo AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Building 31, Room B2B37, 31 Center Drive, MSC-2035, Bethesda, MD 20892-2035, USA, FujitaM@intra.nimh.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 43 EP - 52 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 40 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Macrophages KW - Neuroimaging KW - Positron emission tomography KW - Sampling KW - Benzodiazepine receptors KW - Stroke KW - Brain KW - Microglia KW - biomarkers KW - Inflammation KW - Lung KW - Kinetics KW - Kidney KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21036769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Kinetic+analysis+in+healthy+humans+of+a+novel+positron+emission+tomography+radioligand+to+image+the+peripheral+benzodiazepine+receptor%2C+a+potential+biomarker+for+inflammation&rft.au=Fujita%2C+Masahiro%3BImaizumi%2C+Masao%3BZoghbi%2C+Sami+S%3BFujimura%2C+Yota%3BFarris%2C+Amanda+G%3BSuhara%2C+Tetsuya%3BHong%2C+Jinsoo%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Fujita&rft.aufirst=Masahiro&rft.date=2008-01-01&rft.volume=40&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2007.11.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Inflammation; Positron emission tomography; biomarkers; Neuroimaging; Brain; Benzodiazepine receptors; Sampling; Stroke; Microglia; Kidney; Kinetics; Macrophages; Lung DO - http://dx.doi.org/10.1016/j.neuroimage.2007.11.011 ER - TY - JOUR T1 - Culture of Human A375 Melanoma Cells in the Presence of Fibronectin Causes Expression of Mmp-9 and Activation of Mmp-2 in Culture Supernatants AN - 21035627; 8348012 AB - Interactions between tumor cell surface integrin receptors and extracellular matrix (ECM) ligands play an important role in tumor development, affecting cell survival, proliferation, and migration. Integrin- ECM ligand interaction leads to phosphorylation of focal adhesion kinase (FAK) and activation of mitogen-activated protein kinase (MAPK) pathways. It has been reported that integrins also regulate expression and function of matrix metalloproteinases (MMPs). In this present work, we cultured human A375 melanoma cells in the presence of fibronectin to study fibronectin- integrin mediated modulation of MMP activity. Methods: A375 cells were cultured in serum-free culture medium (SFCM) in the presence of fibronectin (25 mu g/0.75ml), SFCM was collected and gelatin zymography was performed. Western blot and RT-PCR were performed with A375 cells cultured in the presence of fibronectin. Results: Culture of A375 cells in the presence of fibronectin led to expression of MMP-9 and activation of MMP-2 within 2 h. When cells were treated with ERK inhibitor (PD98059) or PI-3K inhibitor (LY294002) and grown in the presence of fibronectin, MMP-9 expression and MMP-2 activation was inhibited. Tyrosine phosphorylation of FAK and ERK were increased in A375 cells grown in the presence of fibronectin. Increased MMP-9 mRNA expression and processing of MT1-MMP were also observed in A375 cells grown in the presence of fibronectin. Conclusions: Our findings indicate culture of A375 cells in SFCM in the presence of fibronectin perhaps generates a signaling cascade that leads to expression of MMP-9 and activation of MMP-2 in culture supernatants within 2 h. The signaling pathway activated is probably the FAK/ERK pathway. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Banerji, Aniruddha AU - Das, Shamik AU - Chatterjee, Amitava AD - Department of Receptor Biology and Tumor Metastasis, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata-700 026, India Y1 - 2008 PY - 2008 DA - 2008 SP - 135 EP - 145 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 USA VL - 27 IS - 2 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts KW - Cell survival KW - Western blotting KW - Cell surface KW - MAP kinase KW - Fibronectin KW - Gelatin KW - Tyrosine KW - Matrix metalloproteinase KW - Cell culture KW - Tumors KW - Tumor cells KW - Melanoma KW - Gene expression KW - Extracellular signal-regulated kinase KW - Phosphorylation KW - Focal adhesion kinase KW - Integrins KW - Extracellular matrix KW - Polymerase chain reaction KW - Gelatinase A KW - Gelatinase B KW - Cell migration KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Culture+of+Human+A375+Melanoma+Cells+in+the+Presence+of+Fibronectin+Causes+Expression+of+Mmp-9+and+Activation+of+Mmp-2+in+Culture+Supernatants&rft.au=Banerji%2C+Aniruddha%3BDas%2C+Shamik%3BChatterjee%2C+Amitava&rft.aulast=Banerji&rft.aufirst=Aniruddha&rft.date=2008-01-01&rft.volume=27&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Cell surface; Western blotting; MAP kinase; Fibronectin; Gelatin; Matrix metalloproteinase; Tyrosine; Cell culture; Tumors; Tumor cells; Melanoma; Gene expression; Extracellular signal-regulated kinase; Focal adhesion kinase; Phosphorylation; Integrins; Extracellular matrix; Polymerase chain reaction; Gelatinase A; Cell migration; Gelatinase B; Signal transduction ER - TY - JOUR T1 - Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB sub(1) receptors in rodents AN - 21033816; 8568982 AB - [ super(11)C]MePPEP is an inverse agonist and a radioligand developed to image cannabinoid CB sub(1) receptors with positron emission tomography (PET). It provides reversible, high specific signal in monkey brain. We assessed [ super(11)C]MePPEP in rodent brain with regard to receptor selectivity, susceptibility to transport by P-glycoprotein (P-gp), sensitivity to displacement by agonists, and accumulation of radiometabolites. We used CB sub(1) receptor knockout mice and P-gp knockout mice to assess receptor selectivity and sensitivity to efflux transport, respectively. Using serial measurements of PET brain activity and plasma concentrations of [ super(11)C]MePPEP, we estimated CB sub(1) receptor density in rat brain as distribution volume. CB sub(1) knockout mice showed only nonspecific brain uptake, and [ super(11)C]MePPEP was not a substrate for P-gp. Direct acting agonists anandamide (10 mg/kg), methanandamide (10 mg/kg), CP 55,940 (1 mg/kg), and indirect agonist URB597 (0.3 and 0.6 mg/kg) failed to displace [ super(11)C]MePPEP, while the inverse agonist rimonabant (3 and 10 mg/kg) displaced > 65% of [ super(11)C]MePPEP. Radiometabolites represented 13% of total radioactivity in brain between 30 and 120 min. [ super(11)C]MePPEP was selective for the CB sub(1) receptor, was not a substrate for P-gp, and was more potently displaced by inverse agonists than agonists. The low potency of agonists suggests either a large receptor reserve or non-overlapping binding sites for agonists and inverse agonists. Radiometabolites of [ super(11)C]MePPEP in brain caused distribution volume to be overestimated by 13%. JF - NeuroImage AU - Terry, Garth AU - Liow, Jeih-San AU - Chernet, Eyassu AU - Zoghbi, Sami S AU - Phebus, Lee AU - Felder, Christian C AU - Tauscher, Johannes AU - Schaus, John M AU - Pike, Victor W AU - Halldin, Christer AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA, robert.innis@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 690 EP - 698 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 41 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Inverse agonists KW - Protein transport KW - Neuroimaging KW - Anandamide KW - Brain KW - P-Glycoprotein KW - Receptor density KW - Positron emission tomography KW - Radioactivity KW - Cannabinoid CB1 receptors KW - W 30910:Imaging KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21033816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Positron+emission+tomography+imaging+using+an+inverse+agonist+radioligand+to+assess+cannabinoid+CB+sub%281%29+receptors+in+rodents&rft.au=Terry%2C+Garth%3BLiow%2C+Jeih-San%3BChernet%2C+Eyassu%3BZoghbi%2C+Sami+S%3BPhebus%2C+Lee%3BFelder%2C+Christian+C%3BTauscher%2C+Johannes%3BSchaus%2C+John+M%3BPike%2C+Victor+W%3BHalldin%2C+Christer%3BInnis%2C+Robert+B&rft.aulast=Terry&rft.aufirst=Garth&rft.date=2008-01-01&rft.volume=41&rft.issue=3&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.03.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Brain; Cannabinoid CB1 receptors; Inverse agonists; Positron emission tomography; Protein transport; Anandamide; Neuroimaging; P-Glycoprotein; Radioactivity; Receptor density DO - http://dx.doi.org/10.1016/j.neuroimage.2008.03.004 ER - TY - JOUR T1 - Striatal sensitivity to reward deliveries and omissions in substance dependent patients AN - 21033714; 8569181 AB - Some motivational theories of substance dependence (SD) posit either pathologically increased or decreased ventral striatum (VS) recruitment by cues for nondrug rewards. The incentive-sensitization hypothesis, alternatively, attributes SD to enhanced incentive salience of drug- predictive cues specifically, with no requirement for altered nondrug incentive processing. We assessed whether individuals undergoing inpatient therapy for SD are characterized by altered recruitment of mesolimbic incentive neurocircuitry by cues and deliveries of nondrug rewards. During functional magnetic resonance imaging, substance-dependent patients (SDP) and controls performed a modified monetary incentive delay task featuring: a) anticipatory cues that signaled opportunities to respond to a target to either win money or avoid losing money, b) notifications of wins and losses, and c) unexpected replacement of reward trial outcomes with a demand to repeat the trial. Both anticipatory reward cues and loss cues elicited similar mood responses and VS activation between SDP and controls. However, in SDP (but not controls), reward notifications also activated VS and mesial frontal cortex, and loss notifications activated anterior insula. Finally, substitution of expected outcomes in reward trials with notifications to repeat the trial deactivated the VS in SDP but not in controls. These data do not suggest that SD is characterized by altered recruitment of VS circuitry by cues for nondrug incentives. Rather, SDP may instead have increased limbic system sensitivity to reward and loss delivery, consistent with the role of impulsivity in SD. JF - NeuroImage AU - Bjork, James M AU - Smith, Ashley R AU - Hommer, Daniel W AD - Division of Clinical Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, USA, jbjork@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1609 EP - 1621 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 42 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Limbic system KW - Data processing KW - Functional magnetic resonance imaging KW - Recruitment KW - Cortex (frontal) KW - Clinical trials KW - Mesolimbic system KW - Mood KW - impulsive behavior KW - Neostriatum KW - Reinforcement KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21033714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Striatal+sensitivity+to+reward+deliveries+and+omissions+in+substance+dependent+patients&rft.au=Bjork%2C+James+M%3BSmith%2C+Ashley+R%3BHommer%2C+Daniel+W&rft.aulast=Bjork&rft.aufirst=James&rft.date=2008-01-01&rft.volume=42&rft.issue=4&rft.spage=1609&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.06.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Reinforcement; Clinical trials; Recruitment; Neostriatum; Mood; Data processing; Limbic system; impulsive behavior; Cortex (frontal); Mesolimbic system; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.06.035 ER - TY - JOUR T1 - Integration of motion correction and physiological noise regression in fMRI AN - 21033535; 8569090 AB - Physiological fluctuations resulting from the heart beat and respiration are a dominant source of noise in fMRI, particularly at high field strengths. Commonly used physiological noise correction techniques, such as RETROspective Image CORrection (RETROICOR), rely critically on the timing of the image acquisition relative to the heart beat, but do not account for the effects of subject motion. Such motion affects the fluctuation amplitude, yet volume registration can distort the timing information. In this study, we aimed to systematically determine the optimal order of volume registration, slice-time correction and RETROICOR in their traditional forms. In addition, we evaluate the sensitivity of RETROICOR to timing errors introduced by the slice acquisition, and we develop a new method of accounting for timing errors introduced by volume registration into physiological correction (motion-modified RETROICOR). Both simulation and resting data indicate that the temporal standard deviation is reduced most by performing volume registration before RETROICOR and slice-time correction after RETROCIOR. While simulations indicate that physiological noise correction with regressors constructed on a slice-by-slice basis more accurately modeled physiological noise compared to using the same regressors for the entire volume, the difference between these regression techniques in subject data was minimal. The motion-modified RETROICOR showed marked improvement in simulations with varying amounts of subject motion, reducing the temporal standard deviation by up to 36% over the traditional RETROICOR. Though to a lesser degree than in simulation, the motion-modified RETROICOR performed better in nearly every voxel in the brain in both high- and low-resolution subject data. JF - NeuroImage AU - Jones, Tyler B AU - Bandettini, Peter A AU - Birn, Rasmus M AD - Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, MD, USA, rbirn@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 582 EP - 590 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 42 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Heart KW - Brain mapping KW - Data processing KW - Respiration KW - Functional magnetic resonance imaging KW - Integration KW - Standard deviation KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21033535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Integration+of+motion+correction+and+physiological+noise+regression+in+fMRI&rft.au=Jones%2C+Tyler+B%3BBandettini%2C+Peter+A%3BBirn%2C+Rasmus+M&rft.aulast=Jones&rft.aufirst=Tyler&rft.date=2008-01-01&rft.volume=42&rft.issue=2&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.05.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Functional magnetic resonance imaging; Heart; Standard deviation; Integration; Respiration; Brain mapping DO - http://dx.doi.org/10.1016/j.neuroimage.2008.05.019 ER - TY - JOUR T1 - An update on Uniform Resource Locator (URL) decay in MEDLINE abstracts and measures for its mitigation AN - 21031627; 8521182 AB - Background For years, Uniform Resource Locator (URL) decay or "link rot" has been a growing concern in the field of biomedical sciences. This paper addresses this issue by examining the status of the URLs published in MEDLINE abstracts, establishing current availability and estimating URL decay in these records from 1994 to 2006. We also reviewed the information provided by the URL to determine if the context that the author cited in writing the paper is the same information presently available in the URL. Lastly, with all the documented recommended methods to preserve URL links, we determined which among them have gained acceptance among authors and publishers. Methods MEDLINE records from 1994 to 2006 from the National Library of Medicine in Extensible Mark-up Language (XML) format were processed yielding 10,208 URL addresses. These were accessed once daily at random times for 30 days. Titles and abstracts were also searched for the presence of archival tools such as WebCite, Persistent URL (PURL) and Digital Object Identifier (DOI). Results Results showed that the average URL length ranged from 13 to 425 characters with a mean length of 35 characters [Standard Deviation (SD) = 13.51; 95% confidence interval (CI) 13.25 to 13.77]. The most common top-level domains were ".org" and ".edu", each with 34%. About 81% of the URL pool was available 90% to 100% of the time, but only 78% of these contained the actual information mentioned in the MEDLINE record. "Dead" URLs constituted 16% of the total. Finally, a survey of archival tool usage showed that since its introduction in 1998, only 519 of all abstracts reviewed had incorporated DOI addresses in their MEDLINE abstracts. Conclusion URL persistence parallels previous studies which showed approximately 81% general availability during the 1-month study period. As peer-reviewed literature remains to be the main source of information in biomedicine, we need to ensure the accuracy and preservation of these links. JF - BMC Medical Informatics and Decision Making AU - Ducut, Erick AU - Liu, Fang AU - Fontelo, Paul AD - Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Bethesda MD, USA, ducute@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 23 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Biotechnology and Bioengineering Abstracts KW - Decision making KW - Standard deviation KW - Reviews KW - Rot KW - Language KW - Preservation KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21031627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Medical+Informatics+and+Decision+Making&rft.atitle=An+update+on+Uniform+Resource+Locator+%28URL%29+decay+in+MEDLINE+abstracts+and+measures+for+its+mitigation&rft.au=Ducut%2C+Erick%3BLiu%2C+Fang%3BFontelo%2C+Paul&rft.aulast=Ducut&rft.aufirst=Erick&rft.date=2008-01-01&rft.volume=8&rft.issue=&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=BMC+Medical+Informatics+and+Decision+Making&rft.issn=1472-6947&rft_id=info:doi/10.1186%2F1472-6947-8-23 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Reviews; Language; Preservation; Standard deviation; Rot; Decision making DO - http://dx.doi.org/10.1186/1472-6947-8-23 ER - TY - JOUR T1 - Sensory stimulation activates both motor and sensory components of the swallowing system AN - 21026853; 8569052 AB - Volitional swallowing in humans involves the coordination of both brainstem and cerebral swallowing control regions. Peripheral sensory inputs are necessary for safe and efficient swallowing, and their importance to the patterned components of swallowing has been demonstrated. However, the role of sensory inputs to the cerebral system during volitional swallowing is less clear. We used four conditions applied during functional magnetic resonance imaging to differentiate between sensory, motor planning, and motor execution components for cerebral control of swallowing. Oral air pulse stimulation was used to examine the effect of sensory input, covert swallowing was used to engage motor planning for swallowing, and overt swallowing was used to activate the volitional swallowing system. Breath-holding was also included to determine whether its effects could account for the activation seen during overt swallowing. Oral air pulse stimulation, covert swallowing and overt swallowing all produced activation in the primary motor cortex, cingulate cortex, putamen and insula. Additional regions of the swallowing cerebral system that were activated by the oral air pulse stimulation condition included the primary and secondary somatosensory cortex and thalamus. Although air pulse stimulation was on the right side only, bilateral cerebral activation occurred. On the other hand, covert swallowing minimally activated sensory regions, but did activate the supplementary motor area and other motor regions. Breath-holding did not account for the activation during overt swallowing. The effectiveness of oral-sensory stimulation for engaging both sensory and motor components of the cerebral swallowing system demonstrates the importance of sensory input in cerebral swallowing control. JF - NeuroImage AU - Lowell, Soren Y AU - Poletto, Christopher J AU - Knorr-Chung, Bethany R AU - Reynolds, Richard C AU - Simonyan, Kristina AU - Ludlow, Christy L AD - Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, 5D-38, 10 Center Drive, MSC 1416, Bethesda, MD 20892-1416, USA, ludlowc@ninds.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 285 EP - 295 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 42 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - swallowing KW - supplementary motor area KW - Cortex (motor) KW - Cerebrum KW - Functional magnetic resonance imaging KW - Brain stem KW - Putamen KW - Thalamus KW - Cortex (cingulate) KW - Cortex (somatosensory) KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21026853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Sensory+stimulation+activates+both+motor+and+sensory+components+of+the+swallowing+system&rft.au=Lowell%2C+Soren+Y%3BPoletto%2C+Christopher+J%3BKnorr-Chung%2C+Bethany+R%3BReynolds%2C+Richard+C%3BSimonyan%2C+Kristina%3BLudlow%2C+Christy+L&rft.aulast=Lowell&rft.aufirst=Soren&rft.date=2008-01-01&rft.volume=42&rft.issue=1&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.04.234 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - swallowing; Cortex (somatosensory); Cortex (cingulate); Cortex (motor); Brain stem; Thalamus; Putamen; Cerebrum; supplementary motor area; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.04.234 ER - TY - JOUR T1 - Mapping resting-state functional connectivity using perfusion MRI AN - 21022800; 8568872 AB - Resting-state, low-frequency (< 0.08 Hz) fluctuations of blood oxygenation level-dependent (BOLD) magnetic resonance signal have been shown to exhibit high correlation among functionally connected regions. However, correlations of cerebral blood flow (CBF) fluctuations during the resting state have not been extensively studied. The main challenges of using arterial spin labeling perfusion magnetic resonance imaging to detect CBF fluctuations are low sensitivity, low temporal resolution, and contamination from BOLD. This work demonstrates CBF-based quantitative functional connectivity mapping by combining continuous arterial spin labeling (CASL) with a neck labeling coil and a multi-channel receiver coil to achieve high perfusion sensitivity. In order to reduce BOLD contamination, the CBF signal was extracted from the CASL signal time course by high frequency filtering. This processing strategy is compatible with sinc interpolation for reducing the timing mismatch between control and label images and has the flexibility of choosing an optimal filter cutoff frequency to minimize BOLD fluctuations. Most subjects studied showed high CBF correlation in bilateral sensorimotor areas with good suppression of BOLD contamination. Root-mean-square CBF fluctuation contributing to bilateral correlation was estimated to be 29 +/- 19% (N = 13) of the baseline perfusion, while BOLD fluctuation was 0.26 +/- 0.14% of the mean intensity (at 3 T and 12.5 ms echo time). JF - NeuroImage AU - Chuang, Kai-Hsiang AU - Van Gelderen, Peter AU - Merkle, Hellmut AU - Bodurka, Jerzy AU - Ikonomidou, Vasiliki N AU - Koretsky, Alan P AU - Duyn, Jeff H AU - Talagala, SLalith AD - Laboratory of Functional and Molecular Imaging, National Institutes of Health, Bethesda, MD, USA, talagala@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1595 EP - 1605 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 40 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Perfusion KW - Contamination KW - Neural networks KW - Functional magnetic resonance imaging KW - Magnetic resonance imaging KW - Neck KW - Filters KW - sensorimotor system KW - N.M.R. KW - Mapping KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21022800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Mapping+resting-state+functional+connectivity+using+perfusion+MRI&rft.au=Chuang%2C+Kai-Hsiang%3BVan+Gelderen%2C+Peter%3BMerkle%2C+Hellmut%3BBodurka%2C+Jerzy%3BIkonomidou%2C+Vasiliki+N%3BKoretsky%2C+Alan+P%3BDuyn%2C+Jeff+H%3BTalagala%2C+SLalith&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2008-01-01&rft.volume=40&rft.issue=4&rft.spage=1595&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cerebral blood flow; Perfusion; Contamination; Neural networks; Mapping; Magnetic resonance imaging; sensorimotor system; N.M.R.; Neck; Filters; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.01.006 ER - TY - JOUR T1 - Wndchrm - an open source utility for biological image analysis AN - 21017777; 8518463 AB - Background Biological imaging is an emerging field, covering a wide range of applications in biological and clinical research. However, while machinery for automated experimenting and data acquisition has been developing rapidly in the past years, automated image analysis often introduces a bottleneck in high content screening. Methods Wndchrm is an open source utility for biological image analysis. The software works by first extracting image content descriptors from the raw image, image transforms, and compound image transforms. Then, the most informative features are selected, and the feature vector of each image is used for classification and similarity measurement. Results Wndchrm has been tested using several publicly available biological datasets, and provided results which are favorably comparable to the performance of task-specific algorithms developed for these datasets. The simple user interface allows researchers who are not knowledgeable in computer vision methods and have no background in computer programming to apply image analysis to their data. Conclusion We suggest that wndchrm can be effectively used for a wide range of biological image analysis tasks. Using wndchrm can allow scientists to perform automated biological image analysis while avoiding the costly challenge of implementing computer vision and pattern recognition algorithms. JF - Source Code for Biology and Medicine AU - Shamir, Lior AU - Orlov, Nikita AU - Eckley, D Mark AU - Macura, Tomasz AU - Johnston, Josiah AU - Goldberg, Ilya G AD - Image Informatics and Computational Biology Unit, Laboratory of Genetics, NIA/NIH, 333 Cassell Dr., Baltimore, MD, 21224, USA, shamirl@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 13 PB - BioMed Central Ltd., Middlesex House VL - 3 SN - 1751-0473, 1751-0473 KW - Biotechnology and Bioengineering Abstracts KW - Pattern recognition KW - Computer programs KW - software KW - Data processing KW - Classification KW - Vision KW - Computers KW - Algorithms KW - Image processing KW - imaging KW - Data acquisition KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21017777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Source+Code+for+Biology+and+Medicine&rft.atitle=Wndchrm+-+an+open+source+utility+for+biological+image+analysis&rft.au=Shamir%2C+Lior%3BOrlov%2C+Nikita%3BEckley%2C+D+Mark%3BMacura%2C+Tomasz%3BJohnston%2C+Josiah%3BGoldberg%2C+Ilya+G&rft.aulast=Shamir&rft.aufirst=Lior&rft.date=2008-01-01&rft.volume=3&rft.issue=&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Source+Code+for+Biology+and+Medicine&rft.issn=17510473&rft_id=info:doi/10.1186%2F1751-0473-3-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Computer programs; Pattern recognition; software; Data processing; Classification; Vision; Computers; Algorithms; Image processing; imaging; Data acquisition DO - http://dx.doi.org/10.1186/1751-0473-3-13 ER - TY - JOUR T1 - Modelling the water budget and the riverflows of the Maritsa basin in Bulgaria AN - 21012231; 8207290 AB - A soil-vegetation-atmosphere transfer model coupled with a macroscale distributed hydrological model was used to simulate the water cycle for a large region in Bulgaria. To do so, an atmospheric forcing was built for two hydrological years (1 October 1995 to 30 September 1997), at an eight km resolution. The impact of the human activities on the rivers (especially hydropower or irrigation) was taken into account. An improvement of the hydrometeorological model was made: for better simulation of summer riverflow, two additional reservoirs were added to simulate the slow component of the runoff. Those reservoirs were calibrated using the observed data of the 1st year, while the 2nd year was used for validation. 56 hydrologic stations and 12 dams were used for the model calibration while 41 river gauges were used for the validation of the model. The results compare well with the daily-observed discharges, with good results obtained over more than 25% of the river gauges. The simulated snow depth was compared to daily measurements at 174 stations and the evolution of the snow water equivalent was validated at 5 sites. The process of melting and refreezing of snow was found to be important in this region. The comparison of the normalized values of simulated versus measured soil moisture showed good correlation. The surface water budget shows large spatial variations due to the elevation influence on the precipitation, soil properties and vegetation variability. An inter-annual difference was observed in the water cycle as the first year was more influenced by Mediterranean climate, while the second year was characterised by continental influence. The energy budget shows a dominating sensible heat component in summer, due to the fact that the water stress limits the evaporation. This study is a first step for the implementation of an operational hydrometeorological model that could be used for real time monitoring and forecasting of water budget components and river flow in Bulgaria. JF - Hydrology and Earth System Sciences AU - Artinyan, E AU - Habets, F AU - Noilhan, J AU - Ledoux, E AU - Dimitrov, D AU - Martin, E AU - Le Moigne, P AD - NIMH-regional centre, 139 Ruski blvd., Plovdiv, Bulgaria Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 21 EP - 37 PB - European Geophysical Society, Max-Planck-Str. 13 37191 Katlenburg-Lindau Germany, [mailto:egs@copernicus.org] VL - 12 IS - 1 SN - 1027-5606, 1027-5606 KW - Aqualine Abstracts; Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Prediction KW - MED, Bulgaria KW - Water budget KW - Hydrologic Budget KW - Man-induced effects KW - Freshwater KW - Hydrologic Cycle KW - Hydrologic Models KW - River Flow KW - Reservoirs KW - Sensible heat KW - Rivers KW - Snow KW - Climates KW - Irrigation KW - River discharge KW - Vegetation KW - Hydrologic cycle KW - Heat KW - MED KW - Atmospheric forcing KW - Bulgaria KW - Q2 09243:Structure, mechanics and thermodynamics KW - AQ 00001:Water Resources and Supplies KW - SW 0835:Streamflow and runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21012231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hydrology+and+Earth+System+Sciences&rft.atitle=Modelling+the+water+budget+and+the+riverflows+of+the+Maritsa+basin+in+Bulgaria&rft.au=Artinyan%2C+E%3BHabets%2C+F%3BNoilhan%2C+J%3BLedoux%2C+E%3BDimitrov%2C+D%3BMartin%2C+E%3BLe+Moigne%2C+P&rft.aulast=Artinyan&rft.aufirst=E&rft.date=2008-01-01&rft.volume=12&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Hydrology+and+Earth+System+Sciences&rft.issn=10275606&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Prediction; Water budget; Snow; Atmospheric forcing; Irrigation; River discharge; Man-induced effects; Hydrologic cycle; Sensible heat; Rivers; Hydrologic Cycle; Hydrologic Models; Heat; Climates; Vegetation; Hydrologic Budget; River Flow; Reservoirs; MED, Bulgaria; MED; Bulgaria; Freshwater ER - TY - JOUR T1 - McCune-Albright syndrome AN - 20999332; 8819346 AB - McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous dysplasia of bone (FD), cafe-au-lait skin spots, and precocious puberty (PP). It is a rare disease with estimated prevalence between 1/100,000 and 1/1,000,000. FD can involve a single or multiple skeletal sites and presents with a limp and/or pain, and, occasionally, a pathologic fracture. Scoliosis is common and may be progressive. In addition to PP (vaginal bleeding or spotting and development of breast tissue in girls, testicular and penile enlargement and precocious sexual behavior in boys), other hyperfunctioning endocrinopathies may be involved including hyperthyroidism, growth hormone excess, Cushing syndrome, and renal phosphate wasting. Cafe-au-lait spots usually appear in the neonatal period, but it is most often PP or FD that brings the child to medical attention. Renal involvement is seen in approximately 50% of the patients with MAS. The disease results from somatic mutations of the GNAS gene, specifically mutations in the cAMP regulating protein, G sub(s )alpha. The extent of the disease is determined by the proliferation, migration and survival of the cell in which the mutation spontaneously occurs during embryonic development. Diagnosis of MAS is usually established on clinical grounds. Plain radiographs are often sufficient to make the diagnosis of FD and biopsy of FD lesions can confirm the diagnosis. The evaluation of patients with MAS should be guided by knowledge of the spectrum of tissues that may be involved, with specific testing for each. Genetic testing is possible, but is not routinely available. Genetic counseling, however, should be offered. Differential diagnoses include neurofibromatosis, osteofibrous dysplasia, non-ossifying fibromas, idiopathic central precocious puberty, and ovarian neoplasm. Treatment is dictated by the tissues affected, and the extent to which they are affected. Generally, some form of surgical intervention is recommended. Bisphosphonates are frequently used in the treatment of FD. Strengthening exercises are recommended to help maintaining the musculature around the FD bone and minimize the risk for fracture. Treatment of all endocrinopathies is required. Malignancies associated with MAS are distinctly rare occurrences. Malignant transformation of FD lesions occurs in probably less than 1% of the cases of MAS. JF - Orphanet Journal of Rare Diseases AU - Dumitrescu, Claudia E AU - Collins, Michael T AD - Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, mosteanuc@nidcr.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 12 PB - BioMed Central Ltd., Middlesex House VL - 3 SN - 1750-1172, 1750-1172 KW - Risk Abstracts KW - sexual behavior KW - pain KW - Hormones KW - surgery KW - risk reduction KW - genetic screening KW - intervention KW - enlargement KW - Lesions KW - plains KW - migration KW - Skin KW - Bone KW - Phosphates KW - Proteins KW - Neonates KW - survival KW - Mutation KW - bisphosphonates KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20999332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Orphanet+Journal+of+Rare+Diseases&rft.atitle=McCune-Albright+syndrome&rft.au=Dumitrescu%2C+Claudia+E%3BCollins%2C+Michael+T&rft.aulast=Dumitrescu&rft.aufirst=Claudia&rft.date=2008-01-01&rft.volume=3&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Orphanet+Journal+of+Rare+Diseases&rft.issn=17501172&rft_id=info:doi/10.1186%2F1750-1172-3-12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mutation; genetic screening; Bone; Lesions; sexual behavior; Phosphates; risk reduction; Hormones; enlargement; intervention; bisphosphonates; surgery; pain; survival; migration; Proteins; plains; Skin; Neonates DO - http://dx.doi.org/10.1186/1750-1172-3-12 ER - TY - JOUR T1 - Antineoplastic Agents. 536. New Sources of Naturally Occurring Cancer Cell Growth Inhibitors from Marine Organisms, Terrestrial Plants, and Microorganisms AN - 20965000; 8133844 AB - Bioassay-guided fractionation of extracts of various plants, marine organisms, and microorganisms has led to the discovery of new natural sources of a number of known compounds that have significant biological activity. The isolation of interesting and valuable cancer cell growth inhibitors including majusculamide C (1), axinastatin 5 (5), bengazoles A (6), B (7), and E (8), manzamine A (10), jaspamide (11), and neoechinulin A (19) has been summarized. JF - Journal of Natural Products AU - Nogawa, Toshihiko AU - Ye, Qing-Hua AU - Herald, Cherry L AU - Williams, Lee AU - Hogan, Fiona AU - Schmidt, Jean M AU - Cichacz, Zbigniew AU - Doubek, Dennis L AU - Goswami, Animesh AU - Pettit, George R AU - Cragg, Gordon M AU - Hoard, Michael S AU - Xu, Jun-Ping AU - Searcy, Justin AU - Tackett, Denise N AU - Chapuis, Jean-Charles AU - Tackett, Larry AU - Hooper, John NA AU - Pettit, Robin K AU - Craciunescu, Felicia AU - Du, Jiang AU - Tan, Rui AD - Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, P.O. Box 872404, Tempe, Arizona 85287-2404, Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, P.O. Box B, Frederick, Maryland 21702-1201 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 438 EP - 444 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 71 IS - 3 SN - 0163-3864, 0163-3864 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Marine Biotechnology Abstracts; Biotechnology and Bioengineering Abstracts KW - Marine microorganisms KW - Marine organisms KW - natural products KW - Plant extracts KW - Cancer KW - Q4 27740:Products KW - W 30940:Products KW - A 01310:Products of Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20965000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=Antineoplastic+Agents.+536.+New+Sources+of+Naturally+Occurring+Cancer+Cell+Growth+Inhibitors+from+Marine+Organisms%2C+Terrestrial+Plants%2C+and+Microorganisms&rft.au=Nogawa%2C+Toshihiko%3BYe%2C+Qing-Hua%3BHerald%2C+Cherry+L%3BWilliams%2C+Lee%3BHogan%2C+Fiona%3BSchmidt%2C+Jean+M%3BCichacz%2C+Zbigniew%3BDoubek%2C+Dennis+L%3BGoswami%2C+Animesh%3BPettit%2C+George+R%3BCragg%2C+Gordon+M%3BHoard%2C+Michael+S%3BXu%2C+Jun-Ping%3BSearcy%2C+Justin%3BTackett%2C+Denise+N%3BChapuis%2C+Jean-Charles%3BTackett%2C+Larry%3BHooper%2C+John+NA%3BPettit%2C+Robin+K%3BCraciunescu%2C+Felicia%3BDu%2C+Jiang%3BTan%2C+Rui&rft.aulast=Nogawa&rft.aufirst=Toshihiko&rft.date=2008-01-01&rft.volume=71&rft.issue=3&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp700738k LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Marine microorganisms; Marine organisms; natural products; Plant extracts; Cancer DO - http://dx.doi.org/10.1021/np700738k ER - TY - JOUR T1 - Metabolic Roles of the M3 Muscarinic Acetylcholine Receptor Studied with M3 Receptor Mutant Mice: A Review AN - 20963813; 8503108 AB - The M3 muscarinic acetylcholine (ACh) receptor (M3 mAChR) is expressed in many central and peripheral tissues. It is a prototypic member of the superfamily of G protein-coupled receptors and preferentially activates G proteins of the Gq family. Recent studies involving the use of newly generated mAChR mutant mice have revealed that the M3 mAChR plays a key role in regulating many important metabolic functions. Phenotypic analyses of mutant mice that either selectively lacked or overexpressed M3 receptors in pancreatic beta -cells indicated that beta -cell M3 mAChRs are essential for maintaining proper insulin release and glucose homeostasis. The experimental data also suggested that strategies aimed at enhancing signaling through beta -cell M3 mAChRs might be beneficial for the treatment of type 2 diabetes. Recent studies with whole body M3 mAChR knockout mice showed that the absence of M3 receptors protected mice against various forms of experimentally or genetically induced obesity and obesity-associated metabolic deficits. Under all experimental conditions tested, M3 receptor-deficient mice showed greatly ameliorated impairments in glucose homeostasis and insulin sensitivity, reduced food intake, and a significant elevation in basal and total energy expenditure, most likely due to increased central sympathetic outflow and increased rate of fatty acid oxidation. These findings are of potential interest for the development of novel therapeutic approaches for the treatment of obesity and associated metabolic disorders. JF - Journal of Receptors and Signal Transduction AU - Gautam, Dinesh AU - Jeon, Jongrye AU - Li, Jian Hua AU - Han, Sung-Jun AU - Hamdan, Fadi F AU - Cui, Yinghong AU - Lu, Huiyan AU - Deng, Chuxia AU - Gavrilova, Oksana AU - Wess, Jurgen AD - Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 93 EP - 108 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 28 IS - 1-2 SN - 1079-9893, 1079-9893 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Obesity KW - Data processing KW - double prime G protein-coupled receptors KW - Metabolic disorders KW - Pancreas KW - Acetylcholine receptors (muscarinic) KW - Glucose KW - Guanine nucleotide-binding protein KW - Homeostasis KW - Insulin KW - Diabetes mellitus KW - Energy expenditure KW - Food intake KW - Reviews KW - Oxidation KW - Fatty acids KW - Acetylcholine KW - Signal transduction KW - N3 11007:Neurobiology KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20963813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Receptors+and+Signal+Transduction&rft.atitle=Metabolic+Roles+of+the+M3+Muscarinic+Acetylcholine+Receptor+Studied+with+M3+Receptor+Mutant+Mice%3A+A+Review&rft.au=Gautam%2C+Dinesh%3BJeon%2C+Jongrye%3BLi%2C+Jian+Hua%3BHan%2C+Sung-Jun%3BHamdan%2C+Fadi+F%3BCui%2C+Yinghong%3BLu%2C+Huiyan%3BDeng%2C+Chuxia%3BGavrilova%2C+Oksana%3BWess%2C+Jurgen&rft.aulast=Gautam&rft.aufirst=Dinesh&rft.date=2008-01-01&rft.volume=28&rft.issue=1-2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Receptors+and+Signal+Transduction&rft.issn=10799893&rft_id=info:doi/10.1080%2F10799890801942002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Obesity; Data processing; double prime G protein-coupled receptors; Pancreas; Metabolic disorders; Acetylcholine receptors (muscarinic); Glucose; Guanine nucleotide-binding protein; Homeostasis; Insulin; Diabetes mellitus; Energy expenditure; Food intake; Reviews; Oxidation; Fatty acids; Acetylcholine; Signal transduction DO - http://dx.doi.org/10.1080/10799890801942002 ER - TY - JOUR T1 - Design of Drug-Resistant Alleles of Type-III Phosphatidylinositol 4- Kinases Using Mutagenesis and Molecular Modeling AN - 20963595; 8110201 AB - Molecular modeling and site directed mutagenesis were used to analyze the structural features determining the unique inhibitor sensitivities of type- III phosphatidylinositol 4-kinase enzymes (PI4Ks). Mutation of a highly conserved Tyr residue that provides the bottom of the hydrophobic pocket for ATP yielded a PI4KIIIbeta2 enzyme that showed greatly reduced wortmannin sensitivity and was catalytically still active. Similar substitutions were not tolerated in the type-IIIalpha enzyme rendering it catalytically inactive. Two conserved Cys residues located in the active site of PI4KIIIalpha were found responsible for the high sensitivity of this enzyme to the oxidizing agent, phenylarsine oxide. Mutation of one of these Cys residues reduced the phenylarsine oxide sensitivity of the enzyme to the same level observed with the PI4KIIIbeta2 protein. In search of inhibitors that would discriminate between the closely related PI4KIIIalpha and -IIIbeta2 enzymes, the PI3Kgamma inhibitor, PIK93, was found to inhibit PI4KIIIbeta2 with significantly greater potency than PI4KIIIalpha. These studies should aid development of subtype-specific inhibitors of type-III PI4Ks and help to better understand the significance of localized PtdIns4P production by the various PI4Ks isoforms in specific cellular compartments. JF - Biochemistry (Washington) AU - Balla, Andras AU - Tuymetova, Galina AU - Toth, Balazs AU - Szentpetery, Zsofia AU - Zhao, Xiaohang AU - Knight, Zachary A AU - Shokat, Kevan AU - Steinbach, Peter J AU - Balla, Tamas AD - Section on Molecular Signal Transduction, Center for Developmental Neuroscience, NICHD, National Institutes of Health, Bethesda, Maryland, Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary, Center for Molecular Modeling, Division of Computational Bioscience, CIT, National Institutes of Health, Bethesda, Maryland, National Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China, Program in Chemistry and Chemical Biology, University of California, San Francisco, California Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1599 EP - 1607 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 47 IS - 6 SN - 0006-2960, 0006-2960 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Molecular modelling KW - phosphatidylinositol KW - Drug resistance KW - Enzymes KW - ATP KW - Hydrophobicity KW - Mutagenesis KW - oxides KW - Mutation KW - Wortmannin KW - Oxidizing agents KW - 1-Phosphatidylinositol 4-kinase KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20963595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Design+of+Drug-Resistant+Alleles+of+Type-III+Phosphatidylinositol+4-+Kinases+Using+Mutagenesis+and+Molecular+Modeling&rft.au=Balla%2C+Andras%3BTuymetova%2C+Galina%3BToth%2C+Balazs%3BSzentpetery%2C+Zsofia%3BZhao%2C+Xiaohang%3BKnight%2C+Zachary+A%3BShokat%2C+Kevan%3BSteinbach%2C+Peter+J%3BBalla%2C+Tamas&rft.aulast=Balla&rft.aufirst=Andras&rft.date=2008-01-01&rft.volume=47&rft.issue=6&rft.spage=1599&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi7017927PII%3AS0006-2960%2870%2901792-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; phosphatidylinositol; Drug resistance; ATP; oxides; Enzymes; Hydrophobicity; Mutation; 1-Phosphatidylinositol 4-kinase; Oxidizing agents; Wortmannin; Mutagenesis DO - http://dx.doi.org/10.1021/bi7017927PII:S0006-2960(70)01792-0 ER - TY - JOUR T1 - Determination and modelling of stereoselective interactions of ligands with drug transporters: A key dimension in the understanding of drug disposition AN - 20944890; 8493296 AB - 1. Stereochemistry is an important dimension in pharmacology and plays a role in every aspect of the pharmacological fate of chiral xenobiotics. This includes small molecule-drug transporter binding. 2. This paper reviews the reported stereoselectivities of substrate and inhibitor interactions with P-glycoprotein and the organic cation transporter obtained using standard functional and binding studies, as well as data obtained from online cellular membrane affinity chromatography studies. 3. The use of stereochemical data in quantitative structure-activity relationship (QSAR) and pharmacophore modelling is also addressed as is the effect of ignoring the fact that small molecule-drug transporter interactions take place in three-dimensional and asymmetric space. JF - Xenobiotica AU - Bhatia, P AU - Kolinski, M AU - Moaddel, R AU - Jozwiak, K AU - Wainer, I W AD - Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 656 EP - 675 VL - 38 IS - 7/8 SN - 0049-8254, 0049-8254 KW - Toxicology Abstracts KW - Data processing KW - Pharmacology KW - organic cation transporter KW - Disposition KW - Xenobiotics KW - Stereochemistry KW - Affinity chromatography KW - P-Glycoprotein KW - Drugs KW - Stereoselectivity KW - Structure-activity relationships KW - pharmacophores KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20944890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=Determination+and+modelling+of+stereoselective+interactions+of+ligands+with+drug+transporters%3A+A+key+dimension+in+the+understanding+of+drug+disposition&rft.au=Bhatia%2C+P%3BKolinski%2C+M%3BMoaddel%2C+R%3BJozwiak%2C+K%3BWainer%2C+I+W&rft.aulast=Bhatia&rft.aufirst=P&rft.date=2008-01-01&rft.volume=38&rft.issue=7%2F8&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250802109207 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Affinity chromatography; P-Glycoprotein; Data processing; organic cation transporter; Pharmacology; Disposition; Xenobiotics; Structure-activity relationships; Stereoselectivity; Drugs; Stereochemistry; pharmacophores DO - http://dx.doi.org/10.1080/00498250802109207 ER - TY - JOUR T1 - Vitamin D Receptor Polymorphisms and Renal Cancer Risk in Central and Eastern Europe AN - 20932885; 8071548 AB - Previous studies investigated the role of vitamin D intake and cancer risk. The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk. Three common VDR gene polymorphisms (BsmI, FokI, TaqI) were evaluated among 925 RCC cases and 1192 controls enrolled in a hospital-based case-control study conducted in Central and Eastern Europe. Overall associations with RCC risk were not observed; however, subgroup analyses revealed associations after stratification by median age of diagnosis and family history of cancer. Among subjects over 60 yr, reduced risks were observed among carriers of the f alleles in the FokI single-nuceotide polymorphism (SNP) (odds ratio [OR] = 0.61 for Ff and OR = 0.74 for ff genotypes) compared to subjects with the FF genotype (P trend = 0.04; P interaction = 0.004). Subjects with the BB BsmI genotype and a positive family history of cancer had lower risk compared to subjects with the bb allele (OR = 0.60; 95% CI: 0.33-1.1; P trend = 0.05). Genotype associations with these subgroups were not modified when dietary sources of vitamin D or calcium were considered. Additional studies of genetic variation in the VDR gene are warranted. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Karami, S AU - Brennan, P AU - Hung, R J AU - Boffetta, P AU - Toro, J AU - Wilson, R T AU - Zaridze, D AU - Navratilova, M AU - Chatterjee, N AU - Mates, D AU - Janout, V AU - Kollarova, H AU - Bencko, V AU - Szeszenia-Dabrowska, N AD - 6120 Executive Blvd EPS 8121, Rockville, MD 20852, USA, karamis@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 367 EP - 372 VL - 71 IS - 5-6 SN - 1528-7394, 1528-7394 KW - Risk Abstracts; Toxicology Abstracts KW - Diets KW - Historical account KW - Calcium homeostasis KW - Age KW - Calcium KW - Gene polymorphism KW - Genetic diversity KW - Europe KW - genetic diversity KW - Genotypes KW - Stratification KW - Cancer KW - risk reduction KW - Calcium metabolism KW - vitamins KW - renal cell carcinoma KW - Single-nucleotide polymorphism KW - Risk factors KW - Kidney KW - Vitamin D receptors KW - Metabolism KW - X 24310:Pharmaceuticals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20932885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Vitamin+D+Receptor+Polymorphisms+and+Renal+Cancer+Risk+in+Central+and+Eastern+Europe&rft.au=Karami%2C+S%3BBrennan%2C+P%3BHung%2C+R+J%3BBoffetta%2C+P%3BToro%2C+J%3BWilson%2C+R+T%3BZaridze%2C+D%3BNavratilova%2C+M%3BChatterjee%2C+N%3BMates%2C+D%3BJanout%2C+V%3BKollarova%2C+H%3BBencko%2C+V%3BSzeszenia-Dabrowska%2C+N&rft.aulast=Karami&rft.aufirst=S&rft.date=2008-01-01&rft.volume=71&rft.issue=5-6&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390701798685 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Calcium metabolism; Calcium homeostasis; Age; renal cell carcinoma; Single-nucleotide polymorphism; Risk factors; Gene polymorphism; Kidney; Genetic diversity; Vitamin D receptors; Diets; risk reduction; Historical account; Calcium; vitamins; genetic diversity; Stratification; Genotypes; Metabolism; Cancer; Europe DO - http://dx.doi.org/10.1080/15287390701798685 ER - TY - JOUR T1 - Physiology, structure, and regulation of the cloned organic anion transporters AN - 20931799; 8493304 AB - 1. The transport of negatively charged drugs, xenobiotics, and metabolites by epithelial tissues, particularly the kidney, plays critical roles in controlling their distribution, concentration, and retention in the body. Thus, organic anion transporters (OATs) impact both their therapeutic efficacy and potential toxicity. 2. This review summarizes current knowledge of the properties and functional roles of the cloned OATs, the relationships between transporter structure and function, and those factors that determine the efficacy of transport. Such factors include plasma protein binding of substrates, genetic polymorphisms among the transporters, and regulation of transporter expression. 3. Clearly, much progress has been made in the decade since the first OAT was cloned. However, unresolved questions remain. Several of these issues -- drug-drug interactions, functional characterization of newly cloned OATs, tissue differences in expression and function, and details of the nature and consequences of transporter regulation at genomic and intracellular sites -- are discussed in the concluding Perspectives section. JF - Xenobiotica AU - Srimaroeng, C AU - Perry, J L AU - Pritchard, J B AD - Laboratory of Pharmacology, Environmental Toxicology Program, National Institute of Environmental Health Sciences, NC, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 889 EP - 935 VL - 38 IS - 7/8 SN - 0049-8254, 0049-8254 KW - Toxicology Abstracts KW - Plasma proteins KW - Anions KW - Structure-function relationships KW - Gene polymorphism KW - Reviews KW - Kidney KW - Metabolites KW - Toxicity KW - genomics KW - Xenobiotics KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20931799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=Physiology%2C+structure%2C+and+regulation+of+the+cloned+organic+anion+transporters&rft.au=Srimaroeng%2C+C%3BPerry%2C+J+L%3BPritchard%2C+J+B&rft.aulast=Srimaroeng&rft.aufirst=C&rft.date=2008-01-01&rft.volume=38&rft.issue=7%2F8&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250801927435 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Plasma proteins; Anions; Structure-function relationships; Reviews; Gene polymorphism; Kidney; Metabolites; Xenobiotics; genomics; Toxicity; Drugs DO - http://dx.doi.org/10.1080/00498250801927435 ER - TY - JOUR T1 - Pharmacodynamic Assessment of Histone Deacetylase Inhibitors: Infrared Vibrational Spectroscopic Imaging of Protein Acetylation AN - 20911971; 8424118 AB - Infrared spectroscopy identifies molecules by detection of vibrational patterns characteristic of molecular bonds. We apply this approach to measure protein acetylation after treatment with histone deacetylase inhibitors. The anticancer activity of histone deacetylase inhibitors (HDACi) is ascribed to the hyperacetylation of both core nucleosomal histones and nonhistone proteins critical to the maintenance of the malignant phenotype (Marks, P. A.; Richon, V. M.; Breslow, R.; Rifkind, R. A. Curr. Opin. Oncol. 2001, 13, 477-483; Mai, A.; Massa, S.; Rotili, D.; Cerbara, I.; Valente, S.; Pezzi, R.; Simeoni, S.; Ragno, R. Med. Res. Rev. 2005, 25, 261-309). After incubation of the peripheral blood mononuclear cells (PBMCs) in vitro with the HDACi SNDX-275, a benzamide drug derivative, vibrational spectral changes in the methyl and methylene stretching mode regions, which reflect concentration-dependent increases in protein acetylation, were detected and quantified. We applied these metrics, based upon spectral differences, to peripheral blood mononuclear cells from patients treated in vivo with this agent. The data demonstrate a new approach to a sensitive assessment of global molecular modifications that is independent of antibodies, requires minimal cell processing, and is easily adapted to high-throughput screening. JF - Analytical Chemistry (Washington) AU - Gutierrez, Martin AU - Kim, Yeong Sang AU - Trepel, Jane B AU - Chen, Tsoching AU - Lee, Min-Jung AU - Kummar, Shivaani AU - Lee, Sunmin AU - Hewitt, Stephen M AU - Levin, Ira W AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, Medical Oncology Branch Y1 - 2008 PY - 2008 DA - 2008 SP - 6390 EP - 6396 PB - American Chemical Society, Box 3337 Columbus OH 43210 USA, [mailto:service@acs.org] VL - 80 IS - 16 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Histone deacetylase KW - Acetylation KW - Peripheral blood mononuclear cells KW - Antibodies KW - Data processing KW - I.R. spectroscopy KW - Nonhistone proteins KW - high-throughput screening KW - imaging KW - Drugs KW - Pharmacodynamics KW - W 30910:Imaging KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20911971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Pharmacodynamic+Assessment+of+Histone+Deacetylase+Inhibitors%3A+Infrared+Vibrational+Spectroscopic+Imaging+of+Protein+Acetylation&rft.au=Gutierrez%2C+Martin%3BKim%2C+Yeong+Sang%3BTrepel%2C+Jane+B%3BChen%2C+Tsoching%3BLee%2C+Min-Jung%3BKummar%2C+Shivaani%3BLee%2C+Sunmin%3BHewitt%2C+Stephen+M%3BLevin%2C+Ira+W&rft.aulast=Gutierrez&rft.aufirst=Martin&rft.date=2008-01-01&rft.volume=80&rft.issue=16&rft.spage=6390&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac800840y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Acetylation; Histone deacetylase; Antibodies; Peripheral blood mononuclear cells; Data processing; Nonhistone proteins; I.R. spectroscopy; high-throughput screening; Drugs; imaging; Pharmacodynamics DO - http://dx.doi.org/10.1021/ac800840y ER - TY - JOUR T1 - Liquid Crystalline Phase of G-Tetrad DNA for NMR Study of Detergent- Solubilized Proteins AN - 20908656; 8323160 AB - The liquid crystalline phase consisting of the potassium salt of the dinucleotide d(GpG) is compatible with detergents commonly used for solubilizing membrane proteins, including dodecylphosphocholine, the lysolipid 1-palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine, and small bicelles consisting of dihexanoyl phosphatidylcholine and dimyristoyl phosphatidylcholine. The chiral nematic liquid crystalline phase of d(GpG) consists of long columns of stacked G-tetrad structures and carry a net negative charge. For water-soluble systems, the protein alignment induced by d(GpG) is very similar to that observed for liquid crystalline Pf1 bacteriophage, but of opposite sign. Alignment of the detergent-solubilized fusion domain of hemagglutinin is demonstrated to be homogeneous and stable, resulting in high quality NMR spectra suitable for the measurement of residual dipolar couplings. JF - Journal of the American Chemical Society AU - Yao, Lishan AU - Bax, Ad AU - Lorieau, Justin AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, bax@nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 7536 EP - 7537 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 130 IS - 24 SN - 1272-7863, 1272-7863 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Salts KW - Detergents KW - Hemagglutinins KW - Lecithin KW - DNA KW - Potassium KW - N.M.R. KW - Membrane proteins KW - W 30910:Imaging KW - N 14845:Miscellaneous KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20908656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Liquid+Crystalline+Phase+of+G-Tetrad+DNA+for+NMR+Study+of+Detergent-+Solubilized+Proteins&rft.au=Yao%2C+Lishan%3BBax%2C+Ad%3BLorieau%2C+Justin&rft.aulast=Yao&rft.aufirst=Lishan&rft.date=2008-01-01&rft.volume=130&rft.issue=24&rft.spage=7536&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=12727863&rft_id=info:doi/10.1021%2Fja801729f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Phages; Salts; Detergents; Hemagglutinins; DNA; Lecithin; Potassium; N.M.R.; Membrane proteins DO - http://dx.doi.org/10.1021/ja801729f ER - TY - JOUR T1 - Atomistic Insights into Rhodopsin Activation from a Dynamic Model AN - 20905631; 8424288 AB - Rhodopsin, the light sensitive receptor responsible for blue-green vision, serves as a prototypical G protein-coupled receptor (GPCR). Upon light absorption, it undergoes a series of conformational changes that lead to the active form, metarhodopsin II (META II), initiating a signaling cascade through binding to the G protein transducin (G sub(t)). Here, we first develop a structural model of META II by applying experimental distance restraints to the structure of lumi-rhodopsin (LUMI), an earlier intermediate. The restraints are imposed by using a combination of biased molecular dynamics simulations and perturbations to an elastic network model. We characterize the motions of the transmembrane helices in the LUMI-to-META II transition and the rearrangement of interhelical hydrogen bonds. We then simulate rhodopsin activation in a dynamic model to study the path leading from LUMI to our META II model for wild-type rhodopsin and a series of mutants. The simulations show a strong correlation between the transition dynamics and the pharmacological phenotypes of the mutants. These results help identify the molecular mechanisms of activation in both wild type and mutant rhodopsin. While static models can provide insights into the mechanisms of ligand recognition and predict ligand affinity, a dynamic model of activation could be applicable to study the pharmacology of other GPCRs and their ligands, offering a key to predictions of basal activity and ligand efficacy. JF - Journal of the American Chemical Society AU - Costanzi, Stefano AU - Hummer, Gerhard AU - Tikhonova, Irina G AU - Engel, Stanislav AU - Best, Robert B AU - Gershengorn, Marvin C AD - Laboratory of Biological Modeling, Laboratory of Chemical Physics, stefanoc@mail.nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 10141 EP - 10149 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 130 IS - 31 SN - 1272-7863, 1272-7863 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Molecular modelling KW - Transducin KW - Rhodopsin KW - double prime G protein-coupled receptors KW - Hydrogen bonding KW - Pharmacology KW - Vision KW - Guanine nucleotide-binding protein KW - Models KW - Light effects KW - Signal transduction KW - W 30940:Products KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20905631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Atomistic+Insights+into+Rhodopsin+Activation+from+a+Dynamic+Model&rft.au=Costanzi%2C+Stefano%3BHummer%2C+Gerhard%3BTikhonova%2C+Irina+G%3BEngel%2C+Stanislav%3BBest%2C+Robert+B%3BGershengorn%2C+Marvin+C&rft.aulast=Costanzi&rft.aufirst=Stefano&rft.date=2008-01-01&rft.volume=130&rft.issue=31&rft.spage=10141&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=12727863&rft_id=info:doi/10.1021%2Fja0765520 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Transducin; Rhodopsin; Vision; Pharmacology; Hydrogen bonding; double prime G protein-coupled receptors; Guanine nucleotide-binding protein; Signal transduction; Light effects; Models DO - http://dx.doi.org/10.1021/ja0765520 ER - TY - JOUR T1 - Pristine (C sub(60)) and Hydroxylated [C sub(60)(OH) sub(24)] Fullerene Phototoxicity towards HaCaT Keratinocytes: Type I vs Type II Mechanisms AN - 20902651; 8236982 AB - The increasing use of fullerene nanomaterials has prompted widespread concern over their biological effects. Herein, we have studied the phototoxicity of gamma -cyclodextrin bicapped pristine C sub(60) [( gamma - CyD) sub(2)/C sub(60)] and its water-soluble derivative C sub(60)(OH) sub(24) toward human keratinocytes. Our results demonstrated that irradiation of ( gamma - CyD) sub(2)/C sub(60) or C sub(60)(OH) sub(24) in D sub(2)O generated singlet oxygen with quantum yields of 0.76 and 0.08, respectively. Irradiation (>400 nm) of C sub(60)(OH) sub(24) generated superoxide as detected by the EPR spin trapping technique; superoxide generation was enhanced by addition of the electron donor nicotinamide adenine dinucleotide (reduced) (NADH). During the irradiation of ( gamma -CyD) sub(2)/C sub(60), superoxide was generated only in the presence of NADH. Cell viability measurements demonstrated that ( gamma - CyD) sub(2)/C sub(60) was about 60 times more phototoxic to human keratinocytes than C sub(60)(OH) sub(24). UVA irradiation of human keratinocytes in the presence of ( gamma -CyD) sub(2)/C sub(60) resulted in a significant rise in intracellular protein-derived peroxides, suggesting a type II mechanism for phototoxicity. UVA irradiation of human keratinocytes in the presence of C sub(60)(OH) sub(24) produced diffuse intracellular fluorescence when the hydrogen peroxide probe Peroxyfluor-1 was present, suggesting a type I mechanism. Our results clearly show that the phototoxicity induced by ( gamma - CyD) sub(2)/C sub(60) is mainly mediated by singlet oxygen with a minor contribution from superoxide, while C sub(60)(OH) sub(24) phototoxicity is mainly due to superoxide. JF - Chemical Research in Toxicology AU - He, Yu-Ying AU - Chignell, Colin F AU - Zhao, Baozhong AU - Bilski, Piotr J AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1056 EP - 1063 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 21 IS - 5 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts KW - E.S.R. KW - Fluorescence KW - NADH KW - Trapping KW - Phototoxicity KW - Oxygen KW - U.V. radiation KW - NAD KW - Radiation KW - Hydrogen peroxide KW - Superoxide KW - Fluorescent indicators KW - Keratinocytes KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20902651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Pristine+%28C+sub%2860%29%29+and+Hydroxylated+%5BC+sub%2860%29%28OH%29+sub%2824%29%5D+Fullerene+Phototoxicity+towards+HaCaT+Keratinocytes%3A+Type+I+vs+Type+II+Mechanisms&rft.au=He%2C+Yu-Ying%3BChignell%2C+Colin+F%3BZhao%2C+Baozhong%3BBilski%2C+Piotr+J&rft.aulast=He&rft.aufirst=Yu-Ying&rft.date=2008-01-01&rft.volume=21&rft.issue=5&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx800056w LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - E.S.R.; Fluorescence; NADH; Trapping; Phototoxicity; Oxygen; U.V. radiation; Radiation; NAD; Hydrogen peroxide; Superoxide; Fluorescent indicators; Keratinocytes DO - http://dx.doi.org/10.1021/tx800056w ER - TY - JOUR T1 - A Cytosolic Iron Chaperone That Delivers Iron to Ferritin AN - 20890927; 8326623 AB - Ferritins are the main iron storage proteins found in animals, plants, and bacteria. The capacity to store iron in ferritin is essential for life in mammals, but the mechanism by which cytosolic iron is delivered to ferritin is unknown. Human ferritins expressed in yeast contain little iron. Human poly (rC)-binding protein 1 (PCBP1) increased the amount of iron loaded into ferritin when expressed in yeast. PCBP1 bound to ferritin in vivo and bound iron and facilitated iron loading into ferritin in vitro. Depletion of PCBP1 in human cells inhibited ferritin iron loading and increased cytosolic iron pools. Thus, PCBP1 can function as a cytosolic iron chaperone in the delivery of iron to ferritin. JF - Science (Washington) AU - Shi, Haifeng AU - Bencze, Krisztina Z AU - Stemmler, Timothy L AU - Philpott, Caroline C AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA., carolinep@intra.niddk.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1207 EP - 1210 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 320 IS - 5880 SN - 0036-8075, 0036-8075 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Ferritin KW - Chaperones KW - storage proteins KW - Iron KW - J 02410:Animal Diseases KW - K 03410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20890927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=A+Cytosolic+Iron+Chaperone+That+Delivers+Iron+to+Ferritin&rft.au=Shi%2C+Haifeng%3BBencze%2C+Krisztina+Z%3BStemmler%2C+Timothy+L%3BPhilpott%2C+Caroline+C&rft.aulast=Shi&rft.aufirst=Haifeng&rft.date=2008-01-01&rft.volume=320&rft.issue=5880&rft.spage=1207&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1157643 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chaperones; Ferritin; storage proteins; Iron DO - http://dx.doi.org/10.1126/science.1157643 ER - TY - JOUR T1 - Toward Multivalent Signaling across G Protein-Coupled Receptors from Poly(amidoamine) Dendrimers AN - 20866184; 8134221 AB - Activation of the A sub(2A) receptor, a G protein-coupled receptor (GPCR), by extracellular adenosine, is antiaggregatory in platelets and anti- inflammatory. Multiple copies of an A sub(2A) agonist, the nucleoside CGS21680, were coupled covalently to PAMAM dendrimers and characterized spectroscopically. A fluorescent PAMAM-CGS21680 conjugate 5 inhibited aggregation of washed human platelets and was internalized. We envision that our multivalent dendrimer conjugates may improve overall pharmacological profiles compared to the monovalent GPCR ligands. JF - Bioconjugate Chemistry AU - Hechler, Beatrice AU - Jacobson, Kenneth A AU - Kim, Yoonkyung AU - Gachet, Christian AU - Klutz, Athena M AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, INSERM U.311, EFS-Alsace Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 406 EP - 411 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 19 IS - 1 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - double prime G protein-coupled receptors KW - nucleosides KW - Platelets KW - Adenosine A2A receptors KW - Adenosine KW - Signal transduction KW - Inflammation KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20866184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Toward+Multivalent+Signaling+across+G+Protein-Coupled+Receptors+from+Poly%28amidoamine%29+Dendrimers&rft.au=Hechler%2C+Beatrice%3BJacobson%2C+Kenneth+A%3BKim%2C+Yoonkyung%3BGachet%2C+Christian%3BKlutz%2C+Athena+M&rft.aulast=Hechler&rft.aufirst=Beatrice&rft.date=2008-01-01&rft.volume=19&rft.issue=1&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc700327u LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - double prime G protein-coupled receptors; nucleosides; Platelets; Adenosine A2A receptors; Adenosine; Inflammation; Signal transduction DO - http://dx.doi.org/10.1021/bc700327u ER - TY - JOUR T1 - Comparative genomics of transcription factors and chromatin proteins in parasitic protists and other eukaryotes AN - 20864044; 7963069 AB - Comparative genomics of parasitic protists and their free-living relatives are profoundly impacting our understanding of the regulatory systems involved in transcription and chromatin dynamics. While some parts of these systems are highly conserved, other parts are rapidly evolving, thereby providing the molecular basis for the variety in the regulatory adaptations of eukaryotes. The gross number of specific transcription factors and chromatin proteins are positively correlated with proteome size in eukaryotes. However, the individual types of specific transcription factors show an enormous variety across different eukaryotic lineages. The dominant families of specific transcription factors even differ between sister lineages, and have been shaped by gene loss and lineage-specific expansions. Recognition of this principle has helped in identifying the hitherto unknown, major specific transcription factors of several parasites, such as apicomplexans, Entamoeba histolytica, Trichomonas vaginalis, Phytophthora and ciliates. Comparative analysis of predicted chromatin proteins from protists allows reconstruction of the early evolutionary history of histone and DNA modification, nucleosome assembly and chromatin-remodeling systems. Many key catalytic, peptide-binding and DNA-binding domains in these systems ultimately had bacterial precursors, but were put together into distinctive regulatory complexes that are unique to the eukaryotes. In the case of histone methylases, histone demethylases and SW beta /SNF2 ATPases, proliferation of paralogous families followed by acquisition of novel domain architectures, seem to have played a major role in producing a diverse set of enzymes that create and respond to an epigenetic code of modified histones. The diversification of histone acetylases and DNA methylases appears to have proceeded via repeated emergence of new versions, most probably via transfers from bacteria to different eukaryotic lineages, again resulting in lineage-specific diversity in epigenetic signals. Even though the key histone modifications are universal to eukaryotes, domain architectures of proteins binding post-translationally modified-histones vary considerably across eukaryotes. This indicates that the histone code might be 'interpreted' differently from model organisms in parasitic protists and their relatives. The complexity of domain architectures of chromatin proteins appears to have increased during eukaryotic evolution. Thus, Trichomonas, Giardia, Naegleria and kinetoplastids have relatively simple domain architectures, whereas apicomplexans and oomycetes have more complex architectures. RNA-dependent post-transcriptional silencing systems, which interact with chromatin-level regulatory systems, show considerable variability across parasitic protists, with complete loss in many apicomplexans and partial loss in Trichomonas vaginalis. This evolutionary synthesis offers a robust scaffold for future investigation of transcription and chromatin structure in parasitic protists. JF - International Journal for Parasitology AU - Iyer, Lakshminarayan M AU - Anantharaman, Vivek AU - Wolf, Maxim Y AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, aravind@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 1 EP - 31 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 38 IS - 1 SN - 0020-7519, 0020-7519 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Transcription factors KW - MYB KW - Histones KW - Methylation demethylation KW - Acetylation KW - Deacetylation KW - Domain architectures KW - Evolution KW - PHD KW - Chromo KW - Bromo KW - Trichomonas vaginalis KW - Naegleria KW - Oomycetes KW - Models KW - Giardia KW - Nucleosomes KW - Methylase KW - epigenetics KW - Phytophthora KW - genomics KW - Adenosinetriphosphatase KW - Adaptations KW - Chromatin remodeling KW - Entamoeba histolytica KW - DNA methylase KW - Enzymes KW - Transcription KW - Ciliates KW - scaffolds KW - Post-translation KW - Post-transcription KW - Trichomonas KW - J 02310:Genetics & Taxonomy KW - G 07790:Other Microorganisms KW - N 14820:DNA Metabolism & Structure KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20864044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+for+Parasitology&rft.atitle=Comparative+genomics+of+transcription+factors+and+chromatin+proteins+in+parasitic+protists+and+other+eukaryotes&rft.au=Iyer%2C+Lakshminarayan+M%3BAnantharaman%2C+Vivek%3BWolf%2C+Maxim+Y%3BAravind%2C+L&rft.aulast=Iyer&rft.aufirst=Lakshminarayan&rft.date=2008-01-01&rft.volume=38&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=International+Journal+for+Parasitology&rft.issn=00207519&rft_id=info:doi/10.1016%2Fj.ijpara.2007.07.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Adaptations; Histones; Adenosinetriphosphatase; Chromatin remodeling; DNA methylase; Transcription; Enzymes; Ciliates; scaffolds; Models; Nucleosomes; Methylase; Post-translation; epigenetics; Transcription factors; genomics; Post-transcription; Evolution; Trichomonas vaginalis; Giardia; Entamoeba histolytica; Phytophthora; Trichomonas; Oomycetes; Naegleria DO - http://dx.doi.org/10.1016/j.ijpara.2007.07.018 ER - TY - JOUR T1 - Extensively Drug-Resistant Tuberculosis in South Korea: Risk Factors and Treatment Outcomes among Patients at a Tertiary Referral Hospital AN - 20859375; 8372737 AB - Background. Extensively drug-resistant (XDR) tuberculosis (TB) is a major public health threat in South Korea. Methods. We analyzed baseline epidemiological data for 250 patients enrolled in an ongoing prospective observational study of TB at a large tertiary referral hospital in South Korea. Results. Twenty-six subjects with XDR TB were identified; all were patients who had previously received TB therapy. Cumulative previous treatment duration (range, 18-34 months; odds ratio [OR], 5.6; 95% confidence interval [CI], 1.0-59), number of previously received second-line anti-TB drugs (OR, 1.3; 95% CI, 1.1-1.5), and female sex (OR, 3.2; 95% CI, 1.1-8.3) were significantly associated with XDR TB in crude analyses. After controlling for other factors in a multivariable model, cumulative previous treatment duration remained significantly associated with XDR TB (OR, 5.8; 95% CI, 1.0-61). Subjects with XDR TB were more likely to produce culture-positive sputum at 6 months, compared with patients with non-multidrug resistant TB (risk ratio, 13; 95% CI, 5.1-53). Kanamycin resistance was found to be predictive of 6-month culture positivity after adjustment for ofloxacin and streptomycin resistance (risk ratio, 3.9; 95% CI, 1.9-11). Conclusions. XDR TB was found to be associated with the cumulative duration of previous treatment with second-line TB drugs among subjects in a tertiary care TB hospital. Patients with XDR TB were more likely to not respond to therapy, and successful conversion of sputum culture results to negative was correlated with initial susceptibility to both fluoroquinolones and kanamycin but not to streptomycin. JF - Clinical Infectious Diseases AU - Jeon, CY AU - Hwang, SH AU - Min, J H AU - Prevots AU - Goldfeder, L C AU - Lee, H AU - Eum, SY AU - Jeon, D S AU - Kang, H S AU - Kim, J H AU - Kim, B J AU - Kim, D Y AU - Holland, S M AU - Via, LE AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 33 North Dr., Bldg. 33, Rm. 2W20G, Bethesda, MD 20892, USA, lvia@niaid.nih.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 42 EP - 49 VL - 46 IS - 1 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Fluoroquinolones KW - Mycobacterium KW - Drug resistance KW - Ofloxacin KW - Kanamycin KW - Streptomycin KW - Models KW - Public health KW - Risk factors KW - Tuberculosis KW - Sputum KW - Drugs KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Extensively+Drug-Resistant+Tuberculosis+in+South+Korea%3A+Risk+Factors+and+Treatment+Outcomes+among+Patients+at+a+Tertiary+Referral+Hospital&rft.au=Jeon%2C+CY%3BHwang%2C+SH%3BMin%2C+J+H%3BPrevots%3BGoldfeder%2C+L+C%3BLee%2C+H%3BEum%2C+SY%3BJeon%2C+D+S%3BKang%2C+H+S%3BKim%2C+J+H%3BKim%2C+B+J%3BKim%2C+D+Y%3BHolland%2C+S+M%3BVia%2C+LE&rft.aulast=Jeon&rft.aufirst=CY&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Fluoroquinolones; Drug resistance; Ofloxacin; Kanamycin; Streptomycin; Public health; Models; Risk factors; Tuberculosis; Sputum; Drugs; Hospitals; Mycobacterium ER - TY - JOUR T1 - Unsupervised estimation of myocardial displacement from tagged MR sequences using nonrigid registration AN - 20857535; 8368679 AB - We propose a fully automatic cardiac motion estimation technique that uses nonrigid registration between temporally adjacent images to compute the myocardial displacement field from tagged MR sequences using as inputs (sources) both horizontally and vertically tagged images. We present a new multisource nonrigid registration algorithm employing a semilocal deformation model that provides controlled smoothness. The method requires no segmentation. We apply a multiresolution optimization strategy for better speed and robustness. The accuracy of the algorithm is assessed on experimental data (animal model) and healthy volunteer data by calculating the root mean square (RMS) difference in position between the estimated tag trajectories and manual tracings outlined by an expert. For the 20000 tag lines analyzed (45 slices over 20-40 time frames), the RMS difference between the automatic tag trajectories and the manually segmented tag trajectories was 0.51 pixels (0.25 mm) for the animal data and 0.49 pixels (0.49 mm) for the human volunteer data. The RMS difference in the separation between adjacent tag lines (RMS_TS) was also assessed, resulting in an RMS_TS of 0.40 pixels (0.19 mm) in the experimental data and 0.52 pixels (0.56 mm) in the volunteer data. These results confirm the subpixel accuracy achieved using the proposed methodology. Magn Reson Med 2007. JF - Magnetic Resonance in Medicine AU - Ledesma-Carbayo, Maria J AU - Derbyshire, J Andrew AU - Sampath, Smita AU - Santos, Andres AU - Desco, Manuel AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, emcveigh@nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 181 EP - 189 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 59 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Segmentation KW - Animal models KW - Algorithms KW - Image processing KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Unsupervised+estimation+of+myocardial+displacement+from+tagged+MR+sequences+using+nonrigid+registration&rft.au=Ledesma-Carbayo%2C+Maria+J%3BDerbyshire%2C+J+Andrew%3BSampath%2C+Smita%3BSantos%2C+Andres%3BDesco%2C+Manuel%3BMcVeigh%2C+Elliot+R&rft.aulast=Ledesma-Carbayo&rft.aufirst=Maria&rft.date=2008-01-01&rft.volume=59&rft.issue=1&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21444 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Algorithms; N.M.R.; Animal models; Segmentation; Image processing; Heart DO - http://dx.doi.org/10.1002/mrm.21444 ER - TY - JOUR T1 - Transcriptional homogenization of rDNA repeats in the episome-based nucleolus induces genome-wide changes in the chromosomal distribution of condensin AN - 20848025; 8244469 AB - Condensin activity establishes and maintains mitotic chromosome condensation, however the mechanisms of condensin recognition of specific chromosomal sites remain unknown. rDNA is the chief condensin binding locus in Saccharomyces cerevisiae, and the level of nucleolar transcription is one of the key factors determining condensin loading to the nucleolar organizer. A new aspect of this transcriptional control is demonstrated in cells with a diffuse (episomal) nucleolar organizer, where active transcription excludes condensin from the transcribed regions of rDNA. Genome-wide ChIP-chip analysis showed that these cells acquire an altered and a more robust pattern of chromosomal condensin distribution, with increased enrichment of wild-type hotspots and with emergence of new sites, most notably in the subtelomeric regions. This genome-wide condensin relocalization induced by the increase in rDNA transcription and, possibly, nucleolar architecture uncovers a novel potential role of the nucleolus in the general chromosome organization. JF - Plasmid AU - Wang, B D AU - Strunnikov, A AD - NICHD, Laboratory of Gene Regulation and Development, 18T Library Drive, Room 106, Bethesda, MD 20892, USA, strunnik@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 45 EP - 53 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 59 IS - 1 SN - 0147-619X, 0147-619X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Nucleoli KW - Chromosomes KW - Hot spots KW - Condensin KW - Transcription KW - Condensation KW - Plasmids KW - Saccharomyces cerevisiae KW - N 14830:RNA KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20848025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plasmid&rft.atitle=Transcriptional+homogenization+of+rDNA+repeats+in+the+episome-based+nucleolus+induces+genome-wide+changes+in+the+chromosomal+distribution+of+condensin&rft.au=Wang%2C+B+D%3BStrunnikov%2C+A&rft.aulast=Wang&rft.aufirst=B&rft.date=2008-01-01&rft.volume=59&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Plasmid&rft.issn=0147619X&rft_id=info:doi/10.1016%2Fj.plasmid.2007.09.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chromosomes; Nucleoli; Hot spots; Condensin; Transcription; Condensation; Plasmids; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1016/j.plasmid.2007.09.003 ER - TY - JOUR T1 - Cytotoxic Xanthones from Psorospermum molluscum from the Madagascar Rain Forest super(△ ) AN - 20844426; 8133850 AB - Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plant Psorospermum cf. molluscum using bioassay-guided fractionation with the Escherichia coli SOS chromotest. The structures of the new dihydrofuranoxanthones, designated 3',4'-deoxy-4'-chloropsoroxanthin- (3',5'-diol) (1) and psoroxanthin (4), were determined on the basis of 2D- NMR, MS, and UV spectroscopic data and are structurally related to the psorospermins, a known class of plant antitumor agents. A new hydroxyprenylated xanthone (5) is also described. Xanthones 1 and 4 showed selective in vitro cytotoxicity against ABAE cells (bovine endothelial cell line). JF - Journal of Natural Products AU - Liu, Xiaohong AU - Cantone, Joseph L AU - Drexler, Dieter M AU - Mamber, Stephen W AU - Hussain, Raouf AU - Huang, Stella AU - Kingston, David GI AU - Leet, John E AU - Newman, David J AU - Fairchild, Craig R AD - Bristol-Myers Squibb Company, Research & Development, Wallingford, Connecticut 06492, Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 460 EP - 463 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 71 IS - 3 SN - 0163-3864, 0163-3864 KW - Microbiology Abstracts B: Bacteriology KW - Endothelial cells KW - Cytotoxicity KW - Rain forests KW - Data processing KW - Escherichia coli KW - natural products KW - N.M.R. KW - Mollusca KW - Rain KW - Plant extracts KW - Antitumor agents KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20844426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=Cytotoxic+Xanthones+from+Psorospermum+molluscum+from+the+Madagascar+Rain+Forest+super%28%E2%96%B3+%29&rft.au=Liu%2C+Xiaohong%3BCantone%2C+Joseph+L%3BDrexler%2C+Dieter+M%3BMamber%2C+Stephen+W%3BHussain%2C+Raouf%3BHuang%2C+Stella%3BKingston%2C+David+GI%3BLeet%2C+John+E%3BNewman%2C+David+J%3BFairchild%2C+Craig+R&rft.aulast=Liu&rft.aufirst=Xiaohong&rft.date=2008-01-01&rft.volume=71&rft.issue=3&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp070523l LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Endothelial cells; Rain forests; Cytotoxicity; Data processing; N.M.R.; natural products; Plant extracts; Rain; Antitumor agents; Escherichia coli; Mollusca DO - http://dx.doi.org/10.1021/np070523l ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 20843542; 8041227 AB - In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data available through NCBI's web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link, Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace, Assembly, and Short Read Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Database of Genotype and Phenotype, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting the web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. JF - Nucleic Acids Research AU - Wheeler, David L AU - Barrett, Tanya AU - Benson, Dennis A AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Edgar, Ron AU - Federhen, Scott AU - Feolo, Michael AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Khovayko, Oleg AU - Landsman, David AU - Lipman, David J AU - Madden, Thomas L AU - Maglott, Donna R AU - Miller, Vadim AU - Ostell, James AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Shumway, Martin AU - Sequeira, Edwin AU - Sherry, Steven T AU - Sirotkin, Karl AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusov, Roman L AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Yaschenko, Eugene AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D13 EP - D21 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 36 SN - 0305-1048, 0305-1048 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - DNA probes KW - Genotypes KW - Cancer KW - Gene expression KW - Influenza KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Taxonomy KW - Protein interaction KW - V 22360:AIDS and HIV KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20843542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Wheeler%2C+David+L%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BEdgar%2C+Ron%3BFederhen%2C+Scott%3BFeolo%2C+Michael%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BKhovayko%2C+Oleg%3BLandsman%2C+David%3BLipman%2C+David+J%3BMadden%2C+Thomas+L%3BMaglott%2C+Donna+R%3BMiller%2C+Vadim%3BOstell%2C+James%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BShumway%2C+Martin%3BSequeira%2C+Edwin%3BSherry%2C+Steven+T%3BSirotkin%2C+Karl%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusov%2C+Roman+L%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BYaschenko%2C+Eugene&rft.aulast=Wheeler&rft.aufirst=David&rft.date=2008-01-01&rft.volume=36&rft.issue=&rft.spage=D13&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; DNA probes; Genotypes; Cancer; Influenza; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Polymerase chain reaction; Taxonomy; Protein interaction; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors AN - 20843224; 7983515 AB - Recent successes in treating genetic immunodeficiencies have demonstrated the therapeutic potential of stem cell gene therapy super(4). However, the use of gammaretroviral vectors in these trials led to insertional activation of nearby oncogenes and leukemias in some study subjects, prompting studies of modified or alternative vector systems super(5). Here we describe the use of foamy virus vectors to treat canine leukocyte adhesion deficiency (CLAD). Four of five dogs with CLAD that received nonmyeloablative conditioning and infusion of autologous, CD34 super(+) hematopoietic stem cells transduced by a foamy virus vector expressing canine CD18 had complete reversal of the CLAD phenotype, which was sustained more than 2 years after infusion. In vitro assays showed correction of the lymphocyte proliferation and neutrophil adhesion defects that characterize CLAD. There were no genotoxic complications, and integration site analysis showed polyclonality of transduced cells and a decreased risk of integration near oncogenes as compared to gammaretroviral vectors. These results represent the first successful use of a foamy virus vector to treat a genetic disease, to our knowledge, and suggest that foamy virus vectors will be effective in treating human hematopoietic diseases. JF - Nature Medicine AU - Bauer Jr, Thomas R AU - Allen, James M AU - Hai, Mehreen AU - Tuschong, Laura M AU - Khan, Iram F AU - Olson, Erik M AU - Adler, Rima L AU - Burkholder, Tanya H AU - Gu, Yu-Chen AU - Russell, David W AU - Hickstein, Dennis D Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 93 EP - 97 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 14 IS - 1 SN - 1078-8956, 1078-8956 KW - Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Autografts KW - Foamy virus KW - Genotoxicity KW - Immunodeficiency KW - Leukocytes (neutrophilic) KW - CD34 antigen KW - Lymphocytes KW - CD18 antigen KW - Integration KW - Leukemia KW - Stem cells KW - Oncogenes KW - Hemopoiesis KW - W 30925:Genetic Engineering KW - F 06955:Immunomodulation & Immunopharmacology KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20843224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Successful+treatment+of+canine+leukocyte+adhesion+deficiency+by+foamy+virus+vectors&rft.au=Bauer+Jr%2C+Thomas+R%3BAllen%2C+James+M%3BHai%2C+Mehreen%3BTuschong%2C+Laura+M%3BKhan%2C+Iram+F%3BOlson%2C+Erik+M%3BAdler%2C+Rima+L%3BBurkholder%2C+Tanya+H%3BGu%2C+Yu-Chen%3BRussell%2C+David+W%3BHickstein%2C+Dennis+D&rft.aulast=Bauer+Jr&rft.aufirst=Thomas&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm1695 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Autografts; Leukemia; Integration; Stem cells; Oncogenes; Genotoxicity; Leukocytes (neutrophilic); Immunodeficiency; Hemopoiesis; CD34 antigen; Lymphocytes; CD18 antigen; Foamy virus DO - http://dx.doi.org/10.1038/nm1695 ER - TY - JOUR T1 - Site-Specific Linking of Biomolecules via Glycan Residues Using Glycosyltransferases AN - 20824032; 8326323 AB - The structural information on glycosyltransferases has revealed that the sugar-donor specificity of these enzymes can be broadened to include modified sugars with a chemical handle that can be utilized for conjugation chemistry. Substitution of Tyr289 to Leu in the catalytic pocket of bovine beta2-1,4- galactosyltransferase generates a novel glycosyltransferase that can transfer not only Gal but also GalNAc or a C2-modified galactose that has a chemical handle, from the corresponding UDP-derivatives, to the non-reducing end GlcNAc residue of a glycoconjugate. Similarly, the wild-type polypeptide- N-acetyl-galactosaminyltransferase, which naturally transfers GalNAc from UDP-GalNAc, can also transfer C2-modified galactose with a chemical handle from its UDP-derivative to the Ser/Thr residue of a polypeptide acceptor substrate that is tagged as a fusion peptide to a non-glycoprotein. The potential of wild-type and mutant glycosyltransferases to produce glycoconjugates carrying sugar moieties with chemical handle makes it possible to conjugate biomolecules with orthogonal reacting groups at specific sites. This methodology assists in the assembly of bio-nanoparticles that are useful for developing targeted drug-delivery systems and contrast agents for magnetic resonance imaging. JF - Biotechnology Progress AU - Qasba, Pradman K AU - Boeggeman, Elizabeth AU - Ramakrishnan, Boopathy AD - Structural Glycobiology Section and Basic Research Program, SAIC- Frederick, Inc., Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 520 EP - 526 PB - American Chemical Society, [mailto:service@acs.org] VL - 24 IS - 3 SN - 8756-7938, 8756-7938 KW - Biotechnology and Bioengineering Abstracts KW - Galactose KW - Sugar KW - glycoconjugates KW - Magnetic resonance imaging KW - Contrast media KW - Enzymes KW - Polysaccharides KW - Glycosyltransferase KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20824032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+Progress&rft.atitle=Site-Specific+Linking+of+Biomolecules+via+Glycan+Residues+Using+Glycosyltransferases&rft.au=Qasba%2C+Pradman+K%3BBoeggeman%2C+Elizabeth%3BRamakrishnan%2C+Boopathy&rft.aulast=Qasba&rft.aufirst=Pradman&rft.date=2008-01-01&rft.volume=24&rft.issue=3&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=Biotechnology+Progress&rft.issn=87567938&rft_id=info:doi/10.1021%2Fbp0704034PII%3AS8756-7938%2807%2900403-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Galactose; Sugar; glycoconjugates; Magnetic resonance imaging; Contrast media; Enzymes; Polysaccharides; Glycosyltransferase DO - http://dx.doi.org/10.1021/bp0704034PII:S8756-7938(07)00403-1 ER - TY - JOUR T1 - Biological and Technical Variables Affecting Immunoassay Recovery of Cytokines from Human Serum and Simulated Vaginal Fluid: A Multicenter Study AN - 20819143; 8323217 AB - The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of sexually transmitted diseases, including HIV-1. Interleukin (IL)-1 beta and IL-6 have been proposed as indicators of inflammation and increased risk of HIV-1 transmission; however, the lack of information regarding detection platforms optimal for vaginal fluids and interlaboratory variation limit their use for microbicide evaluation and other clinical applications. This study examines fluid matrix variants relevant to vaginal sampling techniques and proposes a model for interlaboratory comparisons across current cytokine detection technologies. IL-1 beta and IL-6 standards were measured by 12 laboratories in four countries, using 14 immunoassays and four detection platforms based on absorbance, chemiluminescence, electrochemiluminescence, and fluorescence. International reference preparations of cytokines with defined biological activity were spiked into (1) a defined medium simulating the composition of human vaginal fluid at pH 4.5 and 7.2, (2) physiologic salt solutions (phosphate-buffered saline and saline) commonly used for vaginal lavage sampling in clinical studies of cytokines, and (3) human blood serum. Assays were assessed for reproducibility, linearity, accuracy, and significantly detectable fold difference in cytokine level. Factors with significant impact on cytokine recovery were determined by Kruskal-Wallis analysis of variance with Dunn's multiple comparison test and multiple regression models. All assays showed acceptable intra-assay reproducibility; however, most were associated with significant interlaboratory variation. The smallest reliably detectable cytokine differences (P < 0.05) derived from pooled interlaboratory data varied from 1.5- to 26-fold depending on assay, cytokine, and matrix type. IL-6 but not IL-1 beta determinations were lower in both saline and phosphate- buffered saline as compared to vaginal fluid matrix, with no significant effect of pH. The (electro)chemiluminescence-based assays were most discriminative and consistently detected <2-fold differences within each matrix type. The Luminex-based assays were less discriminative with lower reproducibility between laboratories. These results suggest the need for uniform vaginal sampling techniques and a better understanding of immunoassay platform differences and cross-validation before the biological significance of cytokine variations can be validated in clinical trials. This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface. JF - Analytical Chemistry (Washington) AU - Poli, Guido AU - Sassi, Rosaria Rita AU - Doncel, Gustavo F AU - Cummins, James E AU - Chen, Silvia AU - Alfano, Massimo AU - Donaghay, Melissa AU - Lackman-Smith, Carol AU - Curtis, Kelly AU - Grivel, Jean-Charles AU - Pasicznyk, Jenna-Malia AU - Guzman, Esmeralda AU - Hayes, Madeleine AU - Pallansch-Cokonis, Melanie AU - Shattock, Robin AU - Carbonneil, Cedric AU - Roberts, Paula AU - Cosentino, Lisa AU - Reichelderfer, Patricia AU - Mayer, Kenneth H AU - Saidi, Hela AU - Dezzutti, Charlene S AU - Hillier, Sharon AU - Rodriguez, Irma AU - Margolis, Leonid AU - Belec, Laurent AU - Donoval, Betty AU - Richardson-Harman, Nicola AU - Herold, Betsy AU - Landay, Alan AU - Fichorova, Raina N AD - Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, Microbicides Quality Assurance Program, Southern Research Institute, Frederick, Maryland 21701, Vita-Salute San Raffaele University and Scientific Institute, Milan, Italy, Centre de Recherche des Cordeliers, Paris, France, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, Magee- Womens Research Institute, Pittsburgh, Pennsylvania 15213, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, Rush University Medical Center, Chicago, Illinois 60612, CONRAD, Eastern Virginia Medical School, Norfolk, Virginia 23507, Mount Sinai School of Medicine, New York, New York 10029, St. George's University of London, London, U.K. Y1 - 2008 PY - 2008 DA - 2008 SP - 4741 EP - 4751 PB - American Chemical Society, Box 3337 Columbus OH 43210 USA, [mailto:service@acs.org] VL - 80 IS - 12 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts KW - Interleukin 6 KW - Sexually-transmitted diseases KW - Secretions KW - Interleukin 1 KW - Mucosa KW - Therapeutic applications KW - Clinical trials KW - Models KW - Disease transmission KW - Human immunodeficiency virus 1 KW - Regression analysis KW - Cytokines KW - Sampling KW - Absorbance KW - Chemiluminescence KW - pH effects KW - Fluorescence KW - Data processing KW - Inflammation KW - Salts KW - Blood KW - Vagina KW - Immunoassays KW - microbicides KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20819143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Biological+and+Technical+Variables+Affecting+Immunoassay+Recovery+of+Cytokines+from+Human+Serum+and+Simulated+Vaginal+Fluid%3A+A+Multicenter+Study&rft.au=Poli%2C+Guido%3BSassi%2C+Rosaria+Rita%3BDoncel%2C+Gustavo+F%3BCummins%2C+James+E%3BChen%2C+Silvia%3BAlfano%2C+Massimo%3BDonaghay%2C+Melissa%3BLackman-Smith%2C+Carol%3BCurtis%2C+Kelly%3BGrivel%2C+Jean-Charles%3BPasicznyk%2C+Jenna-Malia%3BGuzman%2C+Esmeralda%3BHayes%2C+Madeleine%3BPallansch-Cokonis%2C+Melanie%3BShattock%2C+Robin%3BCarbonneil%2C+Cedric%3BRoberts%2C+Paula%3BCosentino%2C+Lisa%3BReichelderfer%2C+Patricia%3BMayer%2C+Kenneth+H%3BSaidi%2C+Hela%3BDezzutti%2C+Charlene+S%3BHillier%2C+Sharon%3BRodriguez%2C+Irma%3BMargolis%2C+Leonid%3BBelec%2C+Laurent%3BDonoval%2C+Betty%3BRichardson-Harman%2C+Nicola%3BHerold%2C+Betsy%3BLanday%2C+Alan%3BFichorova%2C+Raina+N&rft.aulast=Poli&rft.aufirst=Guido&rft.date=2008-01-01&rft.volume=80&rft.issue=12&rft.spage=4741&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac702628q LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Data processing; Fluorescence; Sexually-transmitted diseases; Mucosa; Interleukin 1; Secretions; Therapeutic applications; Clinical trials; Disease transmission; Inflammation; Models; Blood; Salts; Vagina; Regression analysis; Cytokines; Absorbance; Sampling; Chemiluminescence; Immunoassays; pH effects; microbicides; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1021/ac702628q ER - TY - JOUR T1 - Procainamide, but not N-Acetylprocainamide, Induces Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis AN - 20812550; 8236990 AB - Procainamide (PA) is a drug that is used to treat tachycardia in postoperative patients or for long-term maintenance of cardiac arrythmias. Unfortunately, its use has also been associated with agranulocytosis. Here, we have investigated the metabolism of PA by myeloperoxidase (MPO) and the formation of an MPO protein free radical. We hypothesized that PA oxidation by MPO/H sub(2)O sub(2) would produce a PA cation radical that, in the absence of a biochemical reductant, would lead to the free radical oxidation of MPO. We utilized a novel anti-DMPO antibody to detect DMPO (5,5-dimethyl-1-pyrroline N-oxide) covalently bound to protein, which forms by the reaction of DMPO with a protein free radical. We found that PA metabolism by MPO/H sub(2)O sub(2) induced the formation of DMPO-MPO, which was inhibited by MPO inhibitors and ascorbate. N-acetyl-PA did not cause DMPO-MPO formation, indicating that the unsubstituted aromatic amine was more oxidizable. PA had a lower calculated ionization potential than N-acetyl-PA. The DMPO adducts of MPO metabolism, as analyzed by electron spin resonance spectroscopy, included a nitrogen- centered radical and a phenyl radical derived from PA, either of which may be involved in the free radical formation on MPO. Furthermore, we also found protein-DMPO adducts in MPO-containing, intact human promyelocytic leukemia cells (HL-60). MPO was affinity-purified from HL-60 cells treated with PA/H sub(2)O sub(2) and was found to contain DMPO using the anti-DMPO antibody. Mass spectrometry analysis confirmed the identity of the protein as human MPO. These findings were also supported by the detection of protein free radicals with electron spin resonance in the cellular cytosolic lysate. The formation of an MPO protein free radical is believed to be mediated by free radical metabolites of PA, which we characterized by spin trapping. We propose that drug-induced free radical formation on MPO may play a role in the origin of agranulocytosis. JF - Chemical Research in Toxicology AU - Siraki, Arno G AU - Ehrenshaft, Marilyn AU - Jiang, JinJie AU - Tomer, Kenneth B AU - Mason, Ronald P AU - Bonini, Marcelo G AU - Deterding, Leesa J AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Dr., Research Triangle Park, NC USA, 27709 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1143 EP - 1153 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 21 IS - 5 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts KW - Heart KW - Tachycardia KW - Peroxidase KW - Adducts KW - Free radicals KW - N-Oxides KW - Promyeloid leukemia KW - Metabolites KW - Spectroscopy KW - Mass spectroscopy KW - Ascorbic acid KW - Neutropenia KW - Antibodies KW - amines KW - Cations KW - Hydrogen peroxide KW - Oxidation KW - Protein turnover KW - Drugs KW - Ionization KW - Aromatics KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20812550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Procainamide%2C+but+not+N-Acetylprocainamide%2C+Induces+Protein+Free+Radical+Formation+on+Myeloperoxidase%3A+A+Potential+Mechanism+of+Agranulocytosis&rft.au=Siraki%2C+Arno+G%3BEhrenshaft%2C+Marilyn%3BJiang%2C+JinJie%3BTomer%2C+Kenneth+B%3BMason%2C+Ronald+P%3BBonini%2C+Marcelo+G%3BDeterding%2C+Leesa+J&rft.aulast=Siraki&rft.aufirst=Arno&rft.date=2008-01-01&rft.volume=21&rft.issue=5&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx700415b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Heart; Free radicals; Adducts; Peroxidase; Tachycardia; N-Oxides; Promyeloid leukemia; Metabolites; Spectroscopy; Mass spectroscopy; Ascorbic acid; Neutropenia; amines; Antibodies; Cations; Hydrogen peroxide; Oxidation; Protein turnover; Ionization; Drugs; Aromatics DO - http://dx.doi.org/10.1021/tx700415b ER - TY - JOUR T1 - Human palatine tonsil: a new potential tissue source of multipotent mesenchymal progenitor cells AN - 20796244; 10885632 AB - Introduction Mesenchymal progenitor cells (MPCs) are multipotent progenitor cells in adult tissues, for example, bone marrow (BM). Current challenges of clinical application of BM-derived MPCs include donor site morbidity and pain as well as low cell yields associated with an age-related decrease in cell number and differentiation potential, underscoring the need to identify alternative sources of MPCs. Recently, MPC sources have diversified; examples include adipose, placenta, umbilicus, trabecular bone, cartilage, and synovial tissue. In the present work, we report the presence of MPCs in human tonsillar tissue. Methods We performed comparative and quantitative analyses of BM-MPCs with a subpopulation of adherent cells isolated from this lymphoid tissue, termed tonsil-derived MPCs (T-MPCs). The expression of surface markers was assessed by fluorescent-activated cell sorting analysis. Differentiation potential of T-MPCs was analyzed histochemically and by reverse transcription-polymerase chain reaction for the expression of lineage-related marker genes. The immunosuppressive properties of MPCs were determined in vitro in mixed lymphocyte reactions. Results Surface epitope analysis revealed that T-MPCs were negative for CD14, CD31, CD34, and CD45 expression and positive for CD29, CD44, CD90, and CD105 expression, a characteristic phenotype of BM-MPCs. Similar to BM-MPCs, T-MPCs could be induced to undergo adipogenic differentiation and, to a lesser extent, osteogenic and chondrogenic differentiation. T-MPCs did not express class II major histocompatibility (MHC) antigens, and in a similar but less pronounced manner compared with BM-MPCs, T-MPCs were immunosuppressive, inhibiting the proliferation of T cells stimulated by allogeneic T cells or by non-specific mitogenic stimuli via an indoleamine 2,3-dioxygenase-dependent mechanism. Conclusion Human palatine T-MPCs represent a new source of progenitor cells, potentially applicable for cell-based therapies. JF - Arthritis Research & Therapy AU - Janjanin, S AU - Djouad, F AU - Shanti, R M AU - Baksh, D AU - Gollapudi, K AU - Prgomet, D AU - Rackwitz, L AU - Joshi, A S AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 1 VL - 10 IS - 4 SN - 1478-6354, 1478-6354 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Mixed leukocyte reaction KW - Therapeutic applications KW - Differentiation KW - Stem cells KW - Placenta KW - Lymphocytes T KW - CD105 antigen KW - CD45 antigen KW - CD34 antigen KW - Bone (trabecular) KW - CD90 antigen KW - CD29 antigen KW - Cell proliferation KW - Age KW - Cartilage KW - CD44 antigen KW - Bone marrow KW - Major histocompatibility complex KW - Pain KW - CD14 antigen KW - Morbidity KW - Tonsil KW - Mesenchyme KW - Epitopes KW - Cell number KW - Umbilicus KW - Lymphoid tissue KW - Surface markers KW - Adherent cells KW - W 30920:Tissue Engineering KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20796244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Human+palatine+tonsil%3A+a+new+potential+tissue+source+of+multipotent+mesenchymal+progenitor+cells&rft.au=Janjanin%2C+S%3BDjouad%2C+F%3BShanti%2C+R+M%3BBaksh%2C+D%3BGollapudi%2C+K%3BPrgomet%2C+D%3BRackwitz%2C+L%3BJoshi%2C+A+S%3BTuan%2C+R+S&rft.aulast=Janjanin&rft.aufirst=S&rft.date=2008-01-01&rft.volume=10&rft.issue=4&rft.spage=R83&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2459 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Tonsil; Major histocompatibility complex; Lymphocytes T; Mesenchyme; Bone (trabecular); CD105 antigen; Bone marrow; CD45 antigen; Mixed leukocyte reaction; Cell proliferation; CD34 antigen; CD90 antigen; Cell number; Epitopes; CD14 antigen; Therapeutic applications; Adherent cells; Placenta; Morbidity; Umbilicus; CD44 antigen; Age; CD29 antigen; Surface markers; Lymphoid tissue; Pain; Cartilage DO - http://dx.doi.org/10.1186/ar2459 ER - TY - JOUR T1 - Functional Characterization and Atomic Force Microscopy of a DNA Repair Protein Conjugated to a Quantum Dot AN - 20786519; 8323423 AB - Quantum dots (QDs) possess highly desirable optical properties that make them ideal fluorescent labels for studying the dynamic behavior of proteins. However, a lack of characterization methods for reliably determining protein- quantum dot conjugate stoichiometry and functionality has impeded their widespread use in single-molecule studies. We used atomic force microscopic (AFM) imaging to demonstrate the 1:1 formation of UvrB-QD conjugates based on an antibody-sandwich method. We show that an agarose gel-based electrophoresis mobility shift assay and AFM can be used to evaluate the DNA binding function of UvrB-QD conjugates. Importantly, we demonstrate that quantum dots can serve as a molecular marker to unambiguously identify the presence of a labeled protein in AFM images. JF - Nano Letters AU - Erie, Dorothy A AU - Wang, Hong AU - Croteau, Deborah L AU - van Houten, Bennett AU - Tessmer, Ingrid AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, Department of Chemistry and Curriculum in Material Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1631 EP - 1637 PB - American Chemical Society, [mailto:service@acs.org] VL - 8 IS - 6 SN - 1530-6984, 1530-6984 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Electrophoresis KW - Quantum dots KW - Optical properties KW - atomic force microscopy KW - Electrophoretic mobility KW - DNA repair KW - N 14820:DNA Metabolism & Structure KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20786519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nano+Letters&rft.atitle=Functional+Characterization+and+Atomic+Force+Microscopy+of+a+DNA+Repair+Protein+Conjugated+to+a+Quantum+Dot&rft.au=Erie%2C+Dorothy+A%3BWang%2C+Hong%3BCroteau%2C+Deborah+L%3Bvan+Houten%2C+Bennett%3BTessmer%2C+Ingrid&rft.aulast=Erie&rft.aufirst=Dorothy&rft.date=2008-01-01&rft.volume=8&rft.issue=6&rft.spage=1631&rft.isbn=&rft.btitle=&rft.title=Nano+Letters&rft.issn=15306984&rft_id=info:doi/10.1021%2Fnl080316l LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Electrophoresis; Quantum dots; Optical properties; atomic force microscopy; DNA repair; Electrophoretic mobility DO - http://dx.doi.org/10.1021/nl080316l ER - TY - JOUR T1 - Characterization of Diversity in Toxicity Mechanism Using in Vitro Cytotoxicity Assays in Quantitative High Throughput Screening AN - 20772066; 8232465 AB - Assessing the potential health risks of environmental chemical compounds is an expensive undertaking that has motivated the development of new alternatives to traditional in vivo toxicological testing. One approach is to stage the evaluation, beginning with less expensive and higher throughput in vitro testing before progressing to more definitive trials. In vitro testing can be used to generate a hypothesis about a compound's mechanism of action, which can then be used to design an appropriate in vivo experiment. Here we begin to address the question of how to design such a battery of in vitro cell-based assays by combining data from two different types of assays, cell viability and caspase activation, with the aim of elucidating the mechanism of action. Because caspase activation is a transient event during apoptosis, it is not possible to design a single end-point assay protocol that would identify all instances of compound-induced caspase activation. Nevertheless, useful information about compound mechanism of action can be obtained from these assays in combination with cell viability data. Unsupervised clustering in combination with Dunn's cluster validity index is a robust method for identifying mechanisms of action without requiring any a priori knowledge about mechanisms of toxicity. The performance of this clustering method is evaluated by comparing the clustering results against literature annotations of compound mechanisms. JF - Chemical Research in Toxicology AU - Huang, Ruili AU - Southall, Noel AU - Cho, Ming-Hsuang AU - Xia, Menghang AU - Inglese, James AU - Austin, Christopher AD - NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 659 EP - 667 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 21 IS - 3 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts KW - Cytotoxicity KW - Apoptosis KW - Caspase KW - Toxicity KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20772066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Characterization+of+Diversity+in+Toxicity+Mechanism+Using+in+Vitro+Cytotoxicity+Assays+in+Quantitative+High+Throughput+Screening&rft.au=Huang%2C+Ruili%3BSouthall%2C+Noel%3BCho%2C+Ming-Hsuang%3BXia%2C+Menghang%3BInglese%2C+James%3BAustin%2C+Christopher&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2008-01-01&rft.volume=21&rft.issue=3&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx700365e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Apoptosis; Caspase; Toxicity DO - http://dx.doi.org/10.1021/tx700365e ER - TY - JOUR T1 - The Glycemia-Cardiovascular Disease Hypothesis: Do recent clinical trials resolve the question? AN - 20745727; 9355671 AB - In 1965, Sir Austin Bradford Hill proposed the types of evidence to be examined to assess whether associations between exposure and disease in population-based epidemiologic studies may be causal: strength, consistency, and specificity of association between exposure and disease occurrence; temporality in that exposure precedes disease; biological gradient where higher level of exposure is associated with higher rate of disease; biological plausibility and coherence of the findings with other knowledge; and experimental evidence showing that reducing exposure reduces subsequent disease. Although some methodologists have suggested alternate approaches to considering causality, Hill's evidence of causality is a foundation of how we think about interpreting epidemiologic data. JF - Clinical and Translational Science AU - Simons-Morton, D G AD - Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA, simonsd@nhlbi.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 185 VL - 1 IS - 3 SN - 1752-8054, 1752-8054 KW - Microbiology Abstracts B: Bacteriology KW - Translation KW - Data processing KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20745727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Translational+Science&rft.atitle=The+Glycemia-Cardiovascular+Disease+Hypothesis%3A+Do+recent+clinical+trials+resolve+the+question%3F&rft.au=Simons-Morton%2C+D+G&rft.aulast=Simons-Morton&rft.aufirst=D&rft.date=2008-01-01&rft.volume=1&rft.issue=3&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Translational+Science&rft.issn=17528054&rft_id=info:doi/10.1111%2Fj.1752-8062.2008.00065.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Translation; Data processing; Clinical trials DO - http://dx.doi.org/10.1111/j.1752-8062.2008.00065.x ER - TY - JOUR T1 - The Genome-wide Association Studies Data Sharing Policy AN - 20744390; 9391288 AB - By early 2006, the cost of genome-wide scanning was decreasing sufficiently to make genotyping of all participants in large-scale population studies feasible. In response, the directors of several National Institutes of Health (NIH) institutes began discussing how to ensure the greatest possible benefit from NIH investments in large-scale genotyping. They engaged the directors of all 27 institutes and centers in developing a policy to enable broad access to deidentified data obtained from NIH-conducted or NIH-supported genome-wide association studies (GWAS) while protecting the privacy and wishes of study participants and respecting the research investments of the primary investigators. The policy, announced on August 28, 2007, applies to all NIH-conducted or NIH-supported GWAS initiated or funded on or after January 25, 2008. Extensive data sharing is in effect for many studies funded or completed before that date. The policy is a logical extension of the extensive data-sharing principles that had been in effect for many studies previously conducted or funded by the NIH, and NIH's support of open access to published results of studies it funds and conducts. The policy addresses data sharing procedures, data access principles, intellectual property rights, and issues regarding the protection of research participants through all phases of GWAS. The NIH continues to have extensive discussions about developing the policy with internal stakeholders and external scientific and lay communities now that it is in the implementation phase. JF - Clinical and Translational Science AU - Shurin, S B AD - National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 91 VL - 1 IS - 2 SN - 1752-8054, 1752-8054 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Translation KW - Data processing KW - Scanning KW - intellectual property KW - Genotyping KW - Population studies KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20744390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Translational+Science&rft.atitle=The+Genome-wide+Association+Studies+Data+Sharing+Policy&rft.au=Shurin%2C+S+B&rft.aulast=Shurin&rft.aufirst=S&rft.date=2008-01-01&rft.volume=1&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Translational+Science&rft.issn=17528054&rft_id=info:doi/10.1111%2Fj.1752-8062.2008.00044.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Translation; Data processing; intellectual property; Scanning; Genotyping; Population studies DO - http://dx.doi.org/10.1111/j.1752-8062.2008.00044.x ER - TY - JOUR T1 - Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study AN - 20735944; 8035947 AB - Meats cooked at high temperatures, such as pan-frying or grilling, are a source of carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons. We prospectively examined the association between meat types, meat cooking methods, meat doneness, and meat mutagens and the risk for prostate cancer in the Agricultural Health Study. We estimated relative risks and 95% confidence intervals (95% CI) for prostate cancer using Cox proportional hazards regression using age as the underlying time metric and adjusting for state of residence, race, smoking status, and family history of prostate cancer. During 197,017 person-years of follow-up, we observed 668 incident prostate cancer cases (613 of these were diagnosed after the first year of follow-up and 140 were advanced cases) among 23,080 men with complete dietary data. We found no association between meat type or specific cooking method and prostate cancer risk. However, intake of well or very well done total meat was associated with a 1.26-fold increased risk of incident prostate cancer (95% CI, 1.02-1.54) and a 1.97-fold increased risk of advanced disease (95% CI, 1.26-3.08) when the highest tertile was compared with the lowest. Risks for the two heterocyclic amines 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline and 2-amino-3,8-dimethylimidazo-[4,5-b]quinoxaline were of borderline significance for incident disease [1.24 (95% CI, 0.96-1.59) and 1.20 (95% CI, 0.93-1.55), respectively] when the highest quintile was compared with the lowest. In conclusion, well and very well done meat was associated with an increased risk for prostate cancer in this cohort. (Cancer Epidemiol Biomarkers Prev 2008; 17(1):80-7) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Koutros, Stella AU - Cross, Amanda J AU - Sandler, Dale P AU - Hoppin, Jane A AU - Ma, Xiaomei AU - Zheng, Tongzhang AU - Alavanja, Michael CR AU - Sinha, Rashmi AD - Occupational and Environmental Epidemiology Branch and Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 80 EP - 87 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 17 IS - 1 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Mutagens KW - Age KW - Smoking KW - Genetics KW - Carcinogenicity KW - prevention KW - cooking KW - prostate cancer KW - Diets KW - Bioindicators KW - Amines KW - Cancer KW - polycyclic aromatic hydrocarbons KW - high temperature KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20735944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Meat+and+Meat+Mutagens+and+Risk+of+Prostate+Cancer+in+the+Agricultural+Health+Study&rft.au=Koutros%2C+Stella%3BCross%2C+Amanda+J%3BSandler%2C+Dale+P%3BHoppin%2C+Jane+A%3BMa%2C+Xiaomei%3BZheng%2C+Tongzhang%3BAlavanja%2C+Michael+CR%3BSinha%2C+Rashmi&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2008-01-01&rft.volume=17&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - prostate cancer; Cancer; Bioindicators; cooking; Mutagens; Amines; Genetics; Carcinogenicity; Diets; polycyclic aromatic hydrocarbons; prevention; high temperature; Smoking; Age ER - TY - JOUR T1 - Children's and Their Parents' Views on Facing Research Risks for the Benefit of Others AN - 20732049; 8034938 AB - OBJECTIVE: To assess children's and parents' attitudes regarding pediatric research that poses minimal risk or a minor increase over minimal risk and does not offer the potential to benefit the child clinically. DESIGN: Separate in-person interviews with children and their parents. SETTING: Clinics where the children were receiving clinical care or participating in clinical research for asthma or cancer. PARTICIPANTS: Children aged 7 to 14 years and their parents or legal guardians. INTERVENTION: In-person interviews. MAIN OUTCOME MEASURES: Respondents' willingness to enroll the child in nonbeneficial research and charitable activities that posed the same risks. RESULTS: Overall, 81 child-parent pairs were interviewed. For a hypothetical study that would not benefit the child and posed a risk of headache, 71% of the children were willing to participate, and 72% of the parents would allow their children to participate. For a hypothetical study that would not benefit the child and posed a very small chance of a broken leg, 43% of the children and 24% of the parents endorsed the child's participation. Overall, respondents were equally willing to have the child help others by participating in nonbeneficial research or by participating in a charitable activity. CONCLUSIONS: Most respondents were willing to have the child participate in some nonbeneficial research, and most did not consider nonbeneficial pediatric research to be more problematic than charitable activities for children. These findings provide empirical data to support the acceptability of exposing children to some research risks for the benefit of others. JF - Archives of Pediatrics & Adolescent Medicine AU - Wendler, David AU - Jenkins, Tammara AD - Department of Bioethics, National Institutes of Health Clinical Center (Dr Wendler), and Pediatric Critical Care and Rehabilitation Research Program, National Center for Medical Rehabilitation Research, National Institute of Child Health and Human Development (Ms Jenkins), Bethesda, Maryland Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 9 EP - 14 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 162 IS - 1 SN - 1072-4710, 1072-4710 KW - Risk Abstracts KW - acceptability KW - intervention KW - Asthma KW - Respiratory diseases KW - Children KW - clinical trials KW - Cancer KW - attitudes KW - Adolescents KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20732049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Pediatrics+%26+Adolescent+Medicine&rft.atitle=Children%27s+and+Their+Parents%27+Views+on+Facing+Research+Risks+for+the+Benefit+of+Others&rft.au=Wendler%2C+David%3BJenkins%2C+Tammara&rft.aulast=Wendler&rft.aufirst=David&rft.date=2008-01-01&rft.volume=162&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Archives+of+Pediatrics+%26+Adolescent+Medicine&rft.issn=10724710&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - acceptability; intervention; Asthma; Respiratory diseases; clinical trials; Children; Adolescents; attitudes; Cancer ER - TY - JOUR T1 - Peripheral Inflammatory Biomarkers and Risk of Parkinson's Disease AN - 20722859; 7932616 AB - Experimental and postmortem evidence indicates a role of neuroinflammation in the pathogenesis of Parkinson's disease. The authors prospectively examined whether plasma concentrations of inflammatory biomarkers assessed before Parkinson's disease diagnosis were predictive of future risk of the disease in a nested case-control study in the United States (1993-2002), including 84 incident cases and 165 matched controls. Blood was collected from patients on average 4.3 years before the diagnosis. After adjustment for potential confounders, higher level of interleukin-6 was associated with a greater risk of Parkinson's disease. Compared with the lowest quintile, the odds ratios were 1.5 for the second, 1.6 for the third, 2.7 for the fourth, and 3.4 for the fifth quintiles (p for trend = 0.03). In contrast, concentrations of other inflammatory biomarkers including C-reactive protein, fibrinogen, and tumor necrosis factor- alpha receptors were not related to the risk. These data suggest that men with high plasma concentrations of interleukin-6 have an increased risk of developing Parkinson's disease. However, this finding should be interpreted with caution because of the small sample size and the lack of associations with other biomarkers of inflammation. JF - American Journal of Epidemiology AU - Chen, Honglei AU - O'Reilly, Eilis J AU - Schwarzschild, Michael A AU - Ascherio, Alberto AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 90 EP - 95 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 167 IS - 1 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Bioindicators KW - Interleukin 6 KW - Parkinson's disease KW - Fibrinogen KW - tumors KW - biomarkers KW - Inflammation KW - Neurodegenerative diseases KW - Blood KW - USA KW - Movement disorders KW - Proteins KW - Tumor necrosis factor- alpha KW - C-reactive protein KW - N3 11028:Neuropharmacology & toxicology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Peripheral+Inflammatory+Biomarkers+and+Risk+of+Parkinson%27s+Disease&rft.au=Chen%2C+Honglei%3BO%27Reilly%2C+Eilis+J%3BSchwarzschild%2C+Michael+A%3BAscherio%2C+Alberto&rft.aulast=Chen&rft.aufirst=Honglei&rft.date=2008-01-01&rft.volume=167&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Blood; Neurodegenerative diseases; Movement disorders; Parkinson's disease; Fibrinogen; Tumor necrosis factor- alpha; biomarkers; C-reactive protein; Inflammation; Bioindicators; Proteins; tumors; USA ER - TY - JOUR T1 - Adenovirus-Mediated Gene Delivery Rescues a Neonatal Lethal Murine Model of muf super(0) Methylmalonic Acidemia AN - 20711974; 8044981 AB - Methylmalonic acidemia (MMA), an autosomal recessive metabolic disorder, is most often caused by mutations in methylmalonyl-CoA mutase (MUT). Severely affected patients typically present with metabolic crisis in the early neonatal period and can perish despite intervention. Survivors follow an unstable course and can require elective liver transplantation to prevent life-threatening metabolic decompensation. Therapeutic alternatives to liver transplantation such as hepatocyte-directed gene and cell therapies lack experimental validation. We have used a murine model of mut super(0) MMA to assess the efficacy of virus-mediated gene therapy to rescue the neonatal lethality seen in the Mut super(-/-) mice. Affected pups and control littermates received either intramuscular or intrahepatic injections of adenovirus carrying the Mut gene expressed under the control of the cytomegalovirus promoter. All of the Mut super(-/-) pups injected via the intramuscular route perished within the first 48 hr of birth. However, more than 50% of the Mut super(-/-) pups that received intrahepatic injections survived beyond weaning (day 15). The treated mutants expressed methylmalonyl-CoA mutase mRNA and protein, and displayed decreased metabolite levels compared with uninjected Mut super(-/-) mice. The results demonstrate that adenovirus-mediated, hepatic methylmalonyl-CoA mutase expression can rescue Mut super(-/-) pups from neonatal mortality and provide proof-of-principle evidence for the efficacy of liver-directed gene delivery in methylmalonic acidemia. JF - Human Gene Therapy AU - Chandler, R J AU - Venditti, C P AD - Building 49, Room 4A62A, Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, venditti@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 53 EP - 60 VL - 19 IS - 1 SN - 1043-0342, 1043-0342 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Mortality KW - Methylmalonyl-CoA mutase KW - Hereditary diseases KW - Gene therapy KW - Metabolic disorders KW - Adenovirus KW - Animal models KW - Weaning KW - Metabolites KW - Cytomegalovirus KW - Liver transplantation KW - mRNA KW - Birth KW - Promoters KW - Lethality KW - Gene transfer KW - Allografts KW - Liver KW - Neonates KW - Mutation KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - V 22410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20711974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Adenovirus-Mediated+Gene+Delivery+Rescues+a+Neonatal+Lethal+Murine+Model+of+muf+super%280%29+Methylmalonic+Acidemia&rft.au=Chandler%2C+R+J%3BVenditti%2C+C+P&rft.aulast=Chandler&rft.aufirst=R&rft.date=2008-01-01&rft.volume=19&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2007.0118 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Methylmalonyl-CoA mutase; Mortality; Hereditary diseases; Gene therapy; Metabolic disorders; Animal models; Weaning; Metabolites; mRNA; Liver transplantation; Birth; Promoters; Lethality; Gene transfer; Allografts; Liver; Neonates; Mutation; Adenovirus; Cytomegalovirus DO - http://dx.doi.org/10.1089/hum.2007.0118 ER - TY - JOUR T1 - An insight into the sialome of the soft tick, Ornithodorus parkeri AN - 20707064; 7939925 AB - While hard ticks (Ixodidae) take several days to feed on their hosts, soft ticks (Argasidae) feed faster, usually taking less than 1h per meal. Saliva assists in the feeding process by providing a cocktail of anti-hemostatic, anti-inflammatory and immunomodullatory compounds. Saliva of hard ticks has been shown to contain several families of genes each having multiple members, while those of soft ticks are relatively unexplored. Analysis of the salivary transcriptome of the soft tick Ornithodorus parkeri, the vector of the relapsing fever agent Borrelia parkeri, indicates that gene duplication events have led to a large expansion of the lipocalin family, as well as of several genes containing Kunitz domains indicative of serine protease inhibitors, and several other gene families also found in hard ticks. Novel protein families with sequence homology to insulin growth factor-binding protein (prostacyclin-stimulating factor), adrenomedulin, serum amyloid A protein precursor and similar to HIV envelope protein were also characterized for the first time in the salivary gland of a blood-sucking arthropod. The sialotranscriptome of O. parkeri confirms that gene duplication events are an important driving force in the creation of salivary cocktails of blood-feeding arthropods, as was observed with hard ticks and mosquitoes. Most of the genes coding for expanded families are homologous to those found in hard ticks, indicating a strong common evolutionary path between the two families. As happens to all genera of blood-sucking arthropods, several new proteins were also found, indicating the process of adaptation to blood feeding still continues to recent times. JF - Insect Biochemistry and Molecular Biology AU - Francischetti, IMB AU - Mans, B J AU - Meng, Z AU - Gudderra, N AU - Veenstra, T D AU - Pham, V M AU - Ribeiro, JMC AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 208928132, USA, ifrancischetti@niaid.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 1 EP - 21 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 38 IS - 1 SN - 0965-1748, 0965-1748 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Entomology Abstracts KW - Feeding KW - Adaptations KW - Serine proteinase KW - Ixodidae KW - Relapsing fever KW - protein families KW - Vectors KW - Salivary gland KW - Insulin KW - Inflammation KW - Blood KW - Argasidae KW - Arthropoda KW - Homology KW - Human immunodeficiency virus KW - Envelope protein KW - Borrelia KW - Saliva KW - Lipocalin KW - Evolution KW - Amyloid KW - J 02410:Animal Diseases KW - G 07810:Insects KW - Z 05330:Reproduction and Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20707064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Insect+Biochemistry+and+Molecular+Biology&rft.atitle=An+insight+into+the+sialome+of+the+soft+tick%2C+Ornithodorus+parkeri&rft.au=Francischetti%2C+IMB%3BMans%2C+B+J%3BMeng%2C+Z%3BGudderra%2C+N%3BVeenstra%2C+T+D%3BPham%2C+V+M%3BRibeiro%2C+JMC&rft.aulast=Francischetti&rft.aufirst=IMB&rft.date=2008-01-01&rft.volume=38&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Insect+Biochemistry+and+Molecular+Biology&rft.issn=09651748&rft_id=info:doi/10.1016%2Fj.ibmb.2007.09.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Feeding; Adaptations; Serine proteinase; Relapsing fever; Vectors; protein families; Salivary gland; Insulin; Inflammation; Blood; Homology; Envelope protein; Saliva; Lipocalin; Evolution; Amyloid; Argasidae; Arthropoda; Human immunodeficiency virus; Ixodidae; Borrelia DO - http://dx.doi.org/10.1016/j.ibmb.2007.09.009 ER - TY - JOUR T1 - Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin AN - 20678682; 8042154 AB - Sickle trait, the heterozygous state of normal hemoglobin A (HbA) and sickle hemoglobin S (HbS), confers protection against malaria in Africa. AS children infected with Plasmodium falciparum are less likely than AA children to suffer the symptoms or severe manifestations of malaria, and they often carry lower parasite densities than AA children. The mechanisms by which sickle trait might confer such malaria protection remain unclear. We have compared the cytoadherence properties of parasitized AS and AA erythrocytes, because it is by these properties that parasitized erythrocytes can sequester in postcapillary microvessels of critical tissues such as the brain and cause the life-threatening complications of malaria. Our results show that the binding of parasitized AS erythrocytes to microvascular endothelial cells and blood monocytes is significantly reduced relative to the binding of parasitized AA erythrocytes. Reduced binding correlates with the altered display of P. falciparum erythrocyte membrane protein-1 (PfEMP-1), the parasite's major cytoadherence ligand and virulence factor on the erythrocyte surface. These findings identify a mechanism of protection for HbS that has features in common with that of hemoglobin C (HbC). Coinherited hemoglobin polymorphisms and naturally acquired antibodies to PfEMP-1 may influence the degree of malaria protection in AS children by further weakening cytoadherence interactions. JF - Proceedings of the National Academy of Sciences, USA AU - Cholera, Rushina AU - Brittain, Nathaniel J AU - Gillrie, Mark R AU - Lopera-Mesa, Tatiana M AU - Diakite, Seidina AS AU - Arie, Takayuki AU - Krause, Michael A AU - Guindo, Aldiouma AU - Tubman, Abby AU - Fujioka, Hisashi AU - Diallo, Dapa A AU - Doumbo, Ogobara K AU - Ho, May AU - Wellems, Thomas E AU - Fairhurst, Rick M AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 991 EP - 996 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 3 SN - 0027-8424, 0027-8424 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Microvasculature KW - Parasites KW - Symptoms KW - Human diseases KW - virulence factors KW - Erythrocytes KW - Brain KW - Malaria KW - Plasmodium falciparum KW - Children KW - Public health KW - Hemoglobin KW - Endothelial cells KW - Virulence KW - Blood KW - Antibodies KW - Africa KW - Monocytes KW - G 07790:Other Microorganisms KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20678682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Impaired+cytoadherence+of+Plasmodium+falciparum-infected+erythrocytes+containing+sickle+hemoglobin&rft.au=Cholera%2C+Rushina%3BBrittain%2C+Nathaniel+J%3BGillrie%2C+Mark+R%3BLopera-Mesa%2C+Tatiana+M%3BDiakite%2C+Seidina+AS%3BArie%2C+Takayuki%3BKrause%2C+Michael+A%3BGuindo%2C+Aldiouma%3BTubman%2C+Abby%3BFujioka%2C+Hisashi%3BDiallo%2C+Dapa+A%3BDoumbo%2C+Ogobara+K%3BHo%2C+May%3BWellems%2C+Thomas+E%3BFairhurst%2C+Rick+M&rft.aulast=Cholera&rft.aufirst=Rushina&rft.date=2008-01-01&rft.volume=105&rft.issue=3&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Virulence; Symptoms; Parasites; Antibodies; Human diseases; Erythrocytes; Malaria; Public health; Endothelial cells; Hemoglobin; Microvasculature; Blood; virulence factors; Brain; Monocytes; Children; Plasmodium falciparum; Africa ER - TY - JOUR T1 - Production of Adenoviral Vectors in 293 Cells: A Case Study of the Adaptation of Attached Cells to Grow in Suspension AN - 20675863; 8195192 AB - A study of the production of adenoviral vectors in suspension 293 cells has been explored. A defined serumfree medium (293 SFM II) formulated without human or animal origin components from Invitrogen was used for the suspension adapted 293 cells. It was demonstrated that the 293 cells can be adapted to grow in suspension using serum free medium. The effect of different cell culture parameters was determined. The production technique demonstrated here is expected to simplify purification processes and circumvents the problems associated with serum containing medium. JF - Open Biotechnology Journal AU - Negrete, Alejandro AU - Ling, Tau Chuan AU - Lyddiatt, Andrew AD - National Institutes of Health, National Heart, Lung, and Blood Institute, 9000 Rockville Pike Bldg 10, Rm 7D04, Bethesda, MD 20892, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 29 EP - 35 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 2 KW - Biotechnology and Bioengineering Abstracts KW - Expression vectors KW - Adaptations KW - Cell culture KW - Purification KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20675863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Open+Biotechnology+Journal&rft.atitle=Production+of+Adenoviral+Vectors+in+293+Cells%3A+A+Case+Study+of+the+Adaptation+of+Attached+Cells+to+Grow+in+Suspension&rft.au=Negrete%2C+Alejandro%3BLing%2C+Tau+Chuan%3BLyddiatt%2C+Andrew&rft.aulast=Negrete&rft.aufirst=Alejandro&rft.date=2008-01-01&rft.volume=2&rft.issue=&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Open+Biotechnology+Journal&rft.issn=1874-0707&rft_id=info:doi/10.2174%2F1874070700802010029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Expression vectors; Adaptations; Cell culture; Purification DO - http://dx.doi.org/10.2174/1874070700802010029 ER - TY - JOUR T1 - Global Epidemiology of Infections Due to Shigella, Salmonella Serotype Typhi, and Enterotoxigenic Escherichia Coli AN - 20629666; 8189589 JF - Epidemiology and Infection AU - Miller, MA AU - Sentz, J AU - Rabaa, MA AU - Mintz, ED AD - Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USA, millemar@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 433 EP - 435 PB - Cambridge University Press, The Edinburgh Building, Shaftesbury Road Cambridge CB2 2RU UK, [mailto:journals@cambridge.org], [URL:http://journals.cambridge.org] VL - 136 IS - 4 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20629666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Global+Epidemiology+of+Infections+Due+to+Shigella%2C+Salmonella+Serotype+Typhi%2C+and+Enterotoxigenic+Escherichia+Coli&rft.au=Miller%2C+MA%3BSentz%2C+J%3BRabaa%2C+MA%3BMintz%2C+ED&rft.aulast=Miller&rft.aufirst=MA&rft.date=2008-01-01&rft.volume=136&rft.issue=4&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS095026880800040X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1017/S095026880800040X ER - TY - JOUR T1 - Public Health Genomics and Genetic Test Evaluation: The Challenge of Conducting Behavioural Research on the Utility of Lifestyle-Genetic Tests AN - 20615298; 9328743 AB - Human genetics research is increasingly concerned with multifactorial conditions such as diabetes and heart disease, which are influenced not only by genetic but also lifestyle factors such as diet and smoking. Although the results of 'lifestyle-genetic' tests using this information could conceivably motivate lifestyle changes in the future, companies are already selling such tests and related lifestyle advice commercially. Some academics and lobby groups have condemned the companies for selling these tests in advance of scientific support. Others are concerned that the tests may not motivate lifestyle improvements, instead causing distress in people receiving adverse test results and complacency in those receiving reassuring results. There is currently no regulatory oversight of genetic test utility, despite consensus in the Public Health Genomics community that clinical utility (including psychological and behavioural impact) of all emerging genetic tests should be evaluated before being introduced for individual use. Clearly, empirical data in this area is much needed, to inform understanding of the potential utility of these tests, and of whether stricter regulation of commercial exploitation is needed. In this article, we review the current situation regarding lifestyle-genetic tests, and discuss the challenges inherent in conducting this kind of behavioural research in the genomics era. JF - Journal of Nutrigenetics and Nutrigenomics AU - Sanderson, S C AU - Wardle, J AU - Humphries, SE AD - Social and Behavioral Research Branch, National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH), Bethesda, Md., USA Y1 - 2008 PY - 2008 DA - 2008 SP - 224 EP - 231 VL - 1 IS - 5 SN - 1661-6499, 1661-6499 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Diets KW - Diabetes mellitus KW - Smoking KW - Data processing KW - Reviews KW - genomics KW - Public health KW - Heart diseases KW - G 07880:Human Genetics KW - W 30910:Imaging KW - N3 11023:Neurogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20615298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrigenetics+and+Nutrigenomics&rft.atitle=Public+Health+Genomics+and+Genetic+Test+Evaluation%3A+The+Challenge+of+Conducting+Behavioural+Research+on+the+Utility+of+Lifestyle-Genetic+Tests&rft.au=Sanderson%2C+S+C%3BWardle%2C+J%3BHumphries%2C+SE&rft.aulast=Sanderson&rft.aufirst=S&rft.date=2008-01-01&rft.volume=1&rft.issue=5&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrigenetics+and+Nutrigenomics&rft.issn=16616499&rft_id=info:doi/10.1159%2F000149826 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Diets; Smoking; Data processing; Reviews; genomics; Heart diseases; Public health DO - http://dx.doi.org/10.1159/000149826 ER - TY - JOUR T1 - MegaMotifBase: a database of structural motifs in protein families and superfamilies AN - 20566568; 8041243 AB - Structural motifs are important for the integrity of a protein fold and can be employed to design and rationalize protein engineering and folding experiments. Such conserved segments represent the conserved core of a family or superfamily and can be crucial for the recognition of potential new members in sequence and structure databases. We present a database, MegaMotifBase, that compiles a set of important structural segments or motifs for protein structures. Motifs are recognized on the basis of both sequence conservation and preservation of important structural features such as amino acid preference, solvent accessibility, secondary structural content, hydrogen-bonding pattern and residue packing. This database provides 3D orientation patterns of the identified motifs in terms of inter-motif distances and torsion angles. Important applications of structural motifs are also provided in several crucial areas such as similar sequence and structure search, multiple sequence alignment and homology modeling. MegaMotifBase can be a useful resource to gain knowledge about structure and functional relationship of proteins. The database can be accessed from the URL http://caps.ncbs.res.in/MegaMotifbase/index.html JF - Nucleic Acids Research AU - Pugalenthi, Ganesan AU - Suganthan, P N AU - Sowdhamini, R AU - Chakrabarti, Saikat AD - School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, Singapore, National Centre for Biological Sciences, UAS-GKVK Campus, Bellary Road, Bangalore 560 065, India and National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D218 EP - D221 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 36 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Protein engineering KW - Nucleotide sequence KW - Solvents KW - protein families KW - Packing KW - Protein structure KW - Databases KW - Protein folding KW - Homology KW - Conserved sequence KW - Preservation KW - Amino acid sequence KW - N 14845:Miscellaneous KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20566568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=MegaMotifBase%3A+a+database+of+structural+motifs+in+protein+families+and+superfamilies&rft.au=Pugalenthi%2C+Ganesan%3BSuganthan%2C+P+N%3BSowdhamini%2C+R%3BChakrabarti%2C+Saikat&rft.aulast=Pugalenthi&rft.aufirst=Ganesan&rft.date=2008-01-01&rft.volume=36&rft.issue=&rft.spage=D218&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein structure; Databases; Homology; Protein folding; Protein engineering; Nucleotide sequence; Solvents; protein families; Conserved sequence; Preservation; Packing; Amino acid sequence ER - TY - JOUR T1 - Construction and Preclinical Characterization of Fc-mGITRL for the Immunotherapy of Cancer AN - 20564872; 8036275 AB - PURPOSE: To provide proper costimulation required for effective cancer T-cell immunity, Fc-GITRL fusion proteins were generated for use in immunotherapy protocols. Experimental Design: Soluble fusion proteins consisting of the Fc fragment of immunoglobulin and the murine glucocorticoid-induced tumor necrosis factor-related receptor ligand (mGITRL) connected with different linkers were genetically engineered and tested for their potency in two BALB/c solid tumor models. RESULTS: In vivo, construct #178-14 (-5aa, -linker) showed the best activity (>90% tumor reduction) at doses ranging from 5 to 25 mu g and was found to be intact by gel electrophoresis. Similar doses used with construct #175-2 (-linker) produced good but not as high tumor regression. Construct #5-1 (+linker), which was found to be relatively unstable by SDS gel electrophoresis, produced 3 months compared with controls that died by day 40. T-cell depletion studies showed that CD8 super(+) T cells play a major role in Fc-mGITRL immunotherapy, and tumors removed from Fc-mGITRL- and DTA-1-treated mice showed a significant influx of granzyme B super(+) lymphocytes compared with controls. Finally, T regulatory (Treg) cell assays showed that, unlike other Fc fusion proteins, all three Fc-mGITRL constructs profoundly suppressed Treg activity. CONCLUSIONS: These studies suggest that a stable, intact Fc-mGITRL fusion protein can provide missing costimulation for the immunotherapy of solid tumors. In addition, Fc-mGITRL may alter Treg activity to enhance its effectiveness for tumor immunotherapy. JF - Clinical Cancer Research AU - Hu, Peisheng AU - Arias, Robyn S AU - Sadun, Rebecca E AU - Nien, Yu-Chih AU - Zhang, Nan AU - Sabzevari, Helen AU - Lutsiak, MEChristine AU - Khawli, Leslie A AU - Epstein, Alan L AD - Authors' Affiliations: Departments of Pathology and Microbiology, Keck School of Medicine at the University of Southern California, Los Angeles, California and Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 579 EP - 588 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 14 IS - 2 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Fc KW - Solid tumors KW - Immunotherapy KW - Animal models KW - Immunity KW - CD8 antigen KW - Cancer KW - Gel electrophoresis KW - Genetic engineering KW - Sodium lauryl sulfate KW - Lymphocytes T KW - Fusion protein KW - Immunoglobulins KW - F 06915:Cancer Immunology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20564872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Construction+and+Preclinical+Characterization+of+Fc-mGITRL+for+the+Immunotherapy+of+Cancer&rft.au=Hu%2C+Peisheng%3BArias%2C+Robyn+S%3BSadun%2C+Rebecca+E%3BNien%2C+Yu-Chih%3BZhang%2C+Nan%3BSabzevari%2C+Helen%3BLutsiak%2C+MEChristine%3BKhawli%2C+Leslie+A%3BEpstein%2C+Alan+L&rft.aulast=Hu&rft.aufirst=Peisheng&rft.date=2008-01-01&rft.volume=14&rft.issue=2&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fc; Solid tumors; Immunotherapy; Animal models; CD8 antigen; Immunity; Gel electrophoresis; Cancer; Genetic engineering; Lymphocytes T; Sodium lauryl sulfate; Fusion protein; Immunoglobulins ER - TY - JOUR T1 - DOMINE: a database of protein domain interactions AN - 20559640; 8041331 AB - DOMINE is a database of known and predicted protein domain interactions compiled from a variety of sources. The database contains domain-domain interactions observed in PDB entries, and those that were predicted by eight different computational approaches. DOMINE contains a total of 20 513 unique domain-domain interactions among 4036 Pfam domains, out of which 4349 are inferred from PDB entries and 17 781 were predicted by at least one computational approach. This database will serve as a valuable resource to those working in the field of protein and domain interactions. DOMINE may not only serve as a reference to experimentalists who test for new protein and domain interactions, but also offers a consolidated dataset for analysis by bioinformaticians who seek to test ideas regarding the underlying factors that control the topological structure of interaction networks. DOMINE is freely available at http://domine.utdallas.edu. JF - Nucleic Acids Research AU - Raghavachari, Balaji AU - Tasneem, Asba AU - Przytycka, Teresa M AU - Jothi, Raja AD - Department of Computer Science, University of Texas at Dallas, Richardson, TX 75083, USA, 10401 Grosvenor Pl, Rockville Pike, MD 20852, USA and National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D656 EP - D661 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 36 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Databases KW - Computer applications KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20559640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=DOMINE%3A+a+database+of+protein+domain+interactions&rft.au=Raghavachari%2C+Balaji%3BTasneem%2C+Asba%3BPrzytycka%2C+Teresa+M%3BJothi%2C+Raja&rft.aulast=Raghavachari&rft.aufirst=Balaji&rft.date=2008-01-01&rft.volume=36&rft.issue=&rft.spage=D656&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Computer applications ER - TY - JOUR T1 - The Molecular Biology Database Collection: 2008 update AN - 20558605; 8041261 AB - The Nucleic Acids Research online Molecular Biology Database Collection is a public repository that lists more than 1000 databases described in this and previous Nucleic Acids Research annual database issues, as well as a selection of molecular biology databases described in other journals. All databases included in this Collection are freely available to the public. The 2008 update includes 1078 databases, 110 more than the previous one. The links to more than 80 databases have been updated and 25 obsolete databases have been removed from the list. The complete database list and summaries are available online at the Nucleic Acids Research web site, http://nar.oxfordjournals.org/. JF - Nucleic Acids Research AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MA 20894, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D2 EP - D4 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 36 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Databases KW - nucleic acids KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20558605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+Molecular+Biology+Database+Collection%3A+2008+update&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=36&rft.issue=&rft.spage=D2&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; nucleic acids ER - TY - JOUR T1 - Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedoensis AN - 20555601; 7985619 AB - Cyclotides are macrocyclic plant peptides characterized by a knotted arrangement of three disulfide bonds. They display a range of interesting bioactivities, including anti-HIV and insecticidal activities. More than 100 different cyclotides have been isolated from two phylogenetically distant plant families, the Rubiaceae and Violaceae. In this study we have characterized the cyclotides from Viola yedoensis, an important Chinese herb from the Violaceae family that has been reported to contain potential anti-HIV agents. From V. yedoensis five new and three known cyclotides were identified and shown to have anti-HIV activity. The most active of these is cycloviolacin Y5, which is one of the most potent of all cyclotides tested so far using in vitro XTT-based anti-HIV assays. Cycloviolacin Y5 is the most hydrophobic of the cyclotides from V. yedoensis. We show that there is a positive correlation between the hydrophobicity and the anti-HIV activity of the new cyclotides and that this trend tracks with their ability to disrupt membranes, as judged from hemolytic assays on human erythrocytes. JF - Journal of Natural Products AU - Wang, Conan KL AU - Colgrave, Michelle L AU - Gustafson, Kirk R AU - Ireland, David C AU - Goransson, Ulf AU - Craik, David J AD - Institute for Molecular Bioscience, Australian Research Council Special Research Centre for Functional and Applied Genomics, University of Queensland, Brisbane, Queensland, 4072, Australia, Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201 Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 47 EP - 52 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 71 IS - 1 SN - 0163-3864, 0163-3864 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Viola KW - Rubiaceae KW - Erythrocytes KW - Violaceae KW - Herbal medicines KW - Disulfide bonds KW - Hydrophobicity KW - natural products KW - Herbs KW - V 22360:AIDS and HIV KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20555601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=Anti-HIV+Cyclotides+from+the+Chinese+Medicinal+Herb+Viola+yedoensis&rft.au=Wang%2C+Conan+KL%3BColgrave%2C+Michelle+L%3BGustafson%2C+Kirk+R%3BIreland%2C+David+C%3BGoransson%2C+Ulf%3BCraik%2C+David+J&rft.aulast=Wang&rft.aufirst=Conan&rft.date=2008-01-01&rft.volume=71&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp070393g LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; Erythrocytes; Disulfide bonds; Herbal medicines; natural products; Hydrophobicity; Herbs; Viola; Rubiaceae; Violaceae DO - http://dx.doi.org/10.1021/np070393g ER - TY - JOUR T1 - Initial Synthesis and Characterization of an alpha7 Nicotinic Receptor Cellular Membrane Affinity Chromatography Column: Effect of Receptor Subtype and Cell Type AN - 20554414; 7986642 AB - In this study, cellular membrane fragments from SH-EP1-pCEP4-halpha7 and alpha7 HEK-293 cell lines were used to synthesize cellular membrane affinity chromatography (CMAC) columns containing functional alpha7 nicotinic acetylcholine receptors, CMAC(alpha7 nAChR) columns. The synthesis of stable columns required the addition of cholesterol to the 2% cholate solubilization/immobilization (s/i) buffer and to the mobile phase. In addition, when membranes from the SH-EP1 cell line were used, L-alpha- phosphatidylserine and L-alpha-phosphatidylethanolamine also had to be added to the s/i buffer. A CMAC(alpha4beta22 nAChR) column was prepared using membrane fragments from a SH-EP1-pCEP4-halpha4beta22 cell line, and this process required the addition of L-alpha-phosphatidylserine and L-alpha- phosphatidylethanolamine to the s/i buffer, but not cholesterol. The s/i buffers from the three columns were compared with the s/i buffer utilized in the preparation of a CMAC(alpha4beta22 nAChR) column prepared using an alpha4beta22 HEK-293 cell line, which required no additions to the 2% cholate s/i buffer. The data demonstrate that both cell type and receptor type affect the protocol required to produce a stable CMAC column and that, at the current time, the development of an optimum immobilization protocol is an empirical process. The results are also consistent with the observation that the alpha7 nAChR is localized in lipid rafts in both of these cell lines and that the cholate detergent removed cholesterol from these microdomains. JF - Analytical Chemistry (Washington) AU - Moaddel, Ruin AU - Oliveira, Regina V AU - Kimura, Tomoko AU - Hyppolite, Patrick AU - Juhaszova, Magdalena AU - Xiao, Yingxian AU - Kellar, Kenneth J AU - Bernier, Michel AU - Wainer, Irving W AD - Gerontology Research Center, National Institutes on Aging, National Institutes of Health, Baltimore, Maryland 21224-6825 Y1 - 2008 PY - 2008 DA - 2008 SP - 48 EP - 54 PB - American Chemical Society, Box 3337 Columbus OH 43210 USA, [mailto:service@acs.org] VL - 80 IS - 1 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts KW - Affinity chromatography KW - phosphatidylserine KW - Detergents KW - Solubilization KW - Cholesterol KW - phosphatidylethanolamine KW - Acetylcholine receptors (nicotinic) KW - Immobilization KW - Lipid rafts KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20554414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Initial+Synthesis+and+Characterization+of+an+alpha7+Nicotinic+Receptor+Cellular+Membrane+Affinity+Chromatography+Column%3A+Effect+of+Receptor+Subtype+and+Cell+Type&rft.au=Moaddel%2C+Ruin%3BOliveira%2C+Regina+V%3BKimura%2C+Tomoko%3BHyppolite%2C+Patrick%3BJuhaszova%2C+Magdalena%3BXiao%2C+Yingxian%3BKellar%2C+Kenneth+J%3BBernier%2C+Michel%3BWainer%2C+Irving+W&rft.aulast=Moaddel&rft.aufirst=Ruin&rft.date=2008-01-01&rft.volume=80&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac701943b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Affinity chromatography; phosphatidylserine; Detergents; Solubilization; phosphatidylethanolamine; Cholesterol; Immobilization; Acetylcholine receptors (nicotinic); Lipid rafts DO - http://dx.doi.org/10.1021/ac701943b ER - TY - JOUR T1 - RNAJunction: a database of RNA junctions and kissing loops for three-dimensional structural analysis and nanodesign AN - 20538218; 8041279 AB - We developed a database called RNAJunction that contains structure and sequence information for RNA structural elements such as helical junctions, internal loops, bulges and loop-loop interactions. Our database provides a user-friendly way of searching structural elements by PDB code, structural classification, sequence, keyword or inter-helix angles. In addition, the structural data was subjected to energy minimization. This database is useful for analyzing RNA structures as well as for designing novel RNA structures on a nanoscale. The database can be accessed at: http://rnajunction.abcc.ncifcrf.gov/ JF - Nucleic Acids Research AU - Bindewald, Eckart AU - Hayes, Robert AU - Yingling, Yaroslava G AU - Kasprzak, Wojciech AU - Shapiro, Bruce A AD - Basic Research Program, SAIC-Frederick and Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, MD 21702, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D392 EP - D397 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 36 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Databases KW - Classification KW - RNA KW - Nucleotide sequence KW - Energy KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20538218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=RNAJunction%3A+a+database+of+RNA+junctions+and+kissing+loops+for+three-dimensional+structural+analysis+and+nanodesign&rft.au=Bindewald%2C+Eckart%3BHayes%2C+Robert%3BYingling%2C+Yaroslava+G%3BKasprzak%2C+Wojciech%3BShapiro%2C+Bruce+A&rft.aulast=Bindewald&rft.aufirst=Eckart&rft.date=2008-01-01&rft.volume=36&rft.issue=&rft.spage=D392&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Databases; RNA; Classification; Energy; Nucleotide sequence ER - TY - JOUR T1 - Drug susceptibility profiling of tuberculous meningitis AN - 20513022; 8045182 AB - Drug-resistant tuberculosis is an increasing problem worldwide. There are few reports of drug susceptibility patterns of Mycobacterium tuberculosis isolated from cases of tuberculous meningitis. A 5-year retrospective study aimed at analysing the drug susceptibility profile of M. tuberculosis isolated from tuberculous meningitis cases was conducted. A total of 366 isolates were analysed. Among these, 301 (82.2%) were sensitive to all the four primary drugs tested, while 65 (17.8%) showed resistance. There were 46 (12.5%) isolates resistant to isoniazid (INH), while 9 (2.4%) demonstrated multidrug resistance. These data suggest that multidrug resistance in tuberculous meningitis is not yet a serious problem. However, a periodic review is required to ascertain the global incidence of drug-resistant tuberculous meningitis. JF - International Journal of Tuberculosis and Lung Disease AU - Nagarathna, S AU - Rafi, W AU - Veenakumari, H B AU - Mani, R AU - Satishchandra, P AU - Chandramuki, A AD - Department of Neuromicrobiology, National Institute of Mental Health and Neuro-sciences (NIMHANS), Bangalore 560 029, India, nagarathnachandrashekar@gmail.com Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 105 EP - 107 VL - 12 IS - 1 SN - 1027-3719, 1027-3719 KW - Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - Lung diseases KW - Tuberculosis KW - Multidrug resistance KW - Drugs KW - Mycobacterium tuberculosis KW - Meningitis KW - Isoniazid KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20513022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Drug+susceptibility+profiling+of+tuberculous+meningitis&rft.au=Nagarathna%2C+S%3BRafi%2C+W%3BVeenakumari%2C+H+B%3BMani%2C+R%3BSatishchandra%2C+P%3BChandramuki%2C+A&rft.aulast=Nagarathna&rft.aufirst=S&rft.date=2008-01-01&rft.volume=12&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drug resistance; Lung diseases; Multidrug resistance; Tuberculosis; Drugs; Isoniazid; Meningitis; Mycobacterium tuberculosis ER - TY - JOUR T1 - Air pollution and risk of urinary bladder cancer in a case-control study in Spain AN - 20508662; 7936958 AB - OBJECTIVES: Air pollution has been associated with an increased risk for lung cancer. We examined whether long-term air pollution is associated with bladder cancer risk. METHODS: Information from a case-control study in Spain that included 1219 incident cases and 1271 hospital controls was used. Information on residential history including several indicators of exposure to air pollution and other potential risk factors was collected in a face-to-face computerised personal interview. Odds ratios (OR) and 95% confidence intervals (95% CI) were adjusted for age, gender, region, smoking, occupation, water contaminants and diet. RESULTS: Living more than 40 years in a city with a population of more than 100 000 was associated with an increased risk for bladder cancer overall (OR 1.30, 95% CI 1.04 to 1.63). Emissions of polycyclic aromatic hydrocarbons and diesel from industries near the residence, as evaluated by experts, were associated with an increased risk (OR 1.29, 95% CI 0.85 to 1.98), while lower or no excess risks were observed for other pollution-related variables. Odds ratios among never smokers tended to be higher than among smokers. CONCLUSIONS: The small to moderate positive associations found for several indices of air pollution and bladder cancer, while suggestive of excess risk, require further evaluation in other settings. JF - Occupational and Environmental Medicine AU - Castano-Vinyals, Gemma AU - Cantor, Kenneth P AU - Malats, Nuria AU - Tardon, Adonina AU - Garcia-Closas, Reina AU - Serra, Consol AU - Carrato, Alfredo AU - Rothman, Nathaniel AU - Vermeulen, Roel AU - Silverman, Debra AU - Dosemeci, Mustafa AU - Kogevinas, Manolis AD - Centre for Research in Environmental Epidemiology, Municipal Institute of Medical Research, Barcelona, Spain. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. Universidad de Oviedo, Oviedo, Spain. Unidad de Investigacion, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Consorci Hospitalari Parc Tauli, Sabadell, Spain. Hospital General de Elche, Elche, Spain. Institute of Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands. Department of Social Medicine, Medical School, University of Crete, Herakleion, Crete, Greece. CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 56 EP - 60 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 1 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts; Pollution Abstracts KW - Historical account KW - Age KW - Spain KW - Pollution effects KW - urinary bladder KW - Smoking KW - Risk factors KW - Emissions KW - Urban areas KW - Lung cancer KW - Diets KW - Polycyclic aromatic hydrocarbons KW - Urinary bladder KW - Cancer KW - Air pollution KW - Gender KW - polycyclic aromatic hydrocarbons KW - Diesel KW - Contaminants KW - emergency medical services KW - Hospitals KW - X 24490:Other KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20508662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Air+pollution+and+risk+of+urinary+bladder+cancer+in+a+case-control+study+in+Spain&rft.au=Castano-Vinyals%2C+Gemma%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BTardon%2C+Adonina%3BGarcia-Closas%2C+Reina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BRothman%2C+Nathaniel%3BVermeulen%2C+Roel%3BSilverman%2C+Debra%3BDosemeci%2C+Mustafa%3BKogevinas%2C+Manolis&rft.aulast=Castano-Vinyals&rft.aufirst=Gemma&rft.date=2008-01-01&rft.volume=65&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Air pollution; Smoking; Polycyclic aromatic hydrocarbons; Urinary bladder; Risk factors; Diesel; Contaminants; Lung cancer; Hospitals; Historical account; Age; Pollution effects; Cancer; urinary bladder; Gender; Emissions; polycyclic aromatic hydrocarbons; emergency medical services; Urban areas; Spain ER - TY - JOUR T1 - Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: Absence of toxicity due to saturating absorption AN - 20473296; 7944484 AB - 1-methyl-d-tryptophan (D-1MT) reverses the immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO), and it is currently being developed both as a vaccine adjuvant and as an immunotherapeutic agent for combination with chemotherapy. The present study examined the pharmacokinetics and toxicity of D-1MT in preparation for clinical trials. Incubation of D-1MT in rat plasma for 24h produced no significant degradation, with <15% of D-1MT being bound to plasma protein. Following oral administration, D-1MT exhibited a larger AUC and V sub(d), longer elimination t sub(1) sub(/) sub(2), and slower clearance in rats than in dogs. When oral doses of D-1MT exceeded levels of 600mg/m super(2)/day in rats, or 1200mg/m super(2)/day in dogs, the C sub(m) sub(a) sub(x) and AUC values decreased, resulting in a corresponding decrease in oral bioavailability. Thus, the doses were indicative of the lowest saturating doses in dogs and rats corresponding with an elimination t sub(1) sub(/) sub(2) of 6.0h and 28.7h, a T sub(m) sub(a) sub(x) of 1h and 8h, and a bioavailability of 47% and 92%, respectively. Tissue concentrations of D-1MT in mice were highest in the kidney, followed by the liver, muscle, heart, lung, and spleen, respectively; 48h post dosing, D-1MT was excreted in the urine (35.1%) and feces (13.5%). Oral administration of D-1MT in rats from 150 to 3000mg/m super(2)/day (25-500mg/kg/day) and in dogs from 600 to 1200mg/m super(2)/day (30 and 60mg/kg/day) for 28 consecutive days did not lead to mortality, adverse events, histopathological lesions, or significant changes in hematology, clinical chemistry, and body weight. These results suggested that 3000 and 1200mg/m super(2)/day were the no-observed-adverse-effect levels in rats and dogs, respectively. Mean plasma concentrations of D-1MT (600 and 1200mg /m super(2)/day) in dogs 1h post dosing were 54.4 and 69.5 mu g/ml on Day 1, respectively, and 53.1 and 66.6 mu g/ml on Day 28, respectively; thus, indicating no increase in plasma D-1MT with a change in dose. In conclusion, D-1MT has little toxicity when administered orally to rats and dogs. Exceeding the saturating dose of D-1MT is unlikely to cause systemic toxicity, since any further increase in D-1MT plasma levels would be minimal. JF - Food and Chemical Toxicology AU - Jia, L AU - Schweikart, K AU - Tomaszewski, J AU - Page, J G AU - Noker, P E AU - Buhrow, SA AU - Reid, J M AU - Ames, M M AU - Munn, D H AD - National Cancer Institute, Rm 8042, 6130 Executive Blvd., Bethesda, MD 20852, United States, jiale@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 203 EP - 211 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 1 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Mortality KW - Sexually-transmitted diseases KW - Chemotherapy KW - Oral administration KW - Muscles KW - Cardiac muscle KW - Spleen KW - Toxicity KW - Adjuvants KW - Clinical trials KW - Pharmacokinetics KW - Plasma proteins KW - Bioavailability KW - Plasma levels KW - Body weight KW - Lung KW - Urine KW - Kidney KW - Liver KW - Vaccines KW - Tryptophan 2,3-dioxygenase KW - Feces KW - Immunosuppression KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20473296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Toxicology+and+pharmacokinetics+of+1-methyl-d-tryptophan%3A+Absence+of+toxicity+due+to+saturating+absorption&rft.au=Jia%2C+L%3BSchweikart%2C+K%3BTomaszewski%2C+J%3BPage%2C+J+G%3BNoker%2C+P+E%3BBuhrow%2C+SA%3BReid%2C+J+M%3BAmes%2C+M+M%3BMunn%2C+D+H&rft.aulast=Jia&rft.aufirst=L&rft.date=2008-01-01&rft.volume=46&rft.issue=1&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2007.07.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Sexually-transmitted diseases; Chemotherapy; Muscles; Oral administration; Spleen; Cardiac muscle; Adjuvants; Toxicity; Clinical trials; Pharmacokinetics; Plasma proteins; Bioavailability; Plasma levels; Body weight; Urine; Lung; Liver; Kidney; Tryptophan 2,3-dioxygenase; Vaccines; Feces; Immunosuppression DO - http://dx.doi.org/10.1016/j.fct.2007.07.017 ER - TY - JOUR T1 - Markers in the epidermal growth factor receptor pathway and skin toxicity during erlotinib treatment AN - 20470389; 7932754 AB - BACKGROUND: Skin toxicity is a common adverse effect of erlotinib and other anti-epidermal growth factor receptor (EGFR) agents. The aim of the study was to explore the relationship between markers in the EGFR pathway and skin rash. PATIENTS AND METHODS: Eighteen patients with metastatic breast cancer were treated with daily oral erlotinib at 150 mg. Skin biopsies were obtained at baseline and after 1 month of treatment in 15 patients. EGFR, phosphorylated EGFR (pEGFR), phosphorylated mitogen-activated protein kinase (pMAPK), and phosphorylated Akt (pAkt) or Ki67 were examined quantitatively by immunohistochemistry. RESULTS: 11 of 18 (61%, 95% confidence interval 35.7% to 82.7%) patients developed skin rash. pAkt at baseline was significantly higher in patients with no rash than those with a grade 1 or 2 rash (18.8 plus or minus 8.3 versus 2.4 plus or minus 1.2 versus 3.3 plus or minus 3.3; P = 0.0017 for trend). There was a trend towards a significant increase of pMAPK in skin posttreatment with increasing grade of rash (no rash versus grade 1 versus grade 2 rash: 4.5 plus or minus 2.3 versus 8.4 plus or minus 4.2 versus 19.4 plus or minus 4.6; P = 0.036). Other markers were not associated with rash. CONCLUSIONS: pAkt was significantly associated with not developing a rash and may have a predictive utility for skin toxicity in patients treated with erlotinib and possibly with other anti-EGFR agents. JF - Annals of Oncology AU - Tan, A R AU - Steinberg, S M AU - Parr, AL AU - Nguyen, D AU - Yang, S X AD - Medical Oncology Branch, Center for Cancer Research. Biostatistics and Data Management Section, Center for Cancer Research. National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 185 EP - 190 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 19 IS - 1 SN - 0923-7534, 0923-7534 KW - Toxicology Abstracts KW - MAP kinase KW - Skin KW - Epidermal growth factor receptors KW - Biopsy KW - Toxicity KW - Metastases KW - Exanthema KW - Growth factor receptors KW - AKT protein KW - Breast cancer KW - Immunohistochemistry KW - Side effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20470389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Oncology&rft.atitle=Markers+in+the+epidermal+growth+factor+receptor+pathway+and+skin+toxicity+during+erlotinib+treatment&rft.au=Tan%2C+A+R%3BSteinberg%2C+S+M%3BParr%2C+AL%3BNguyen%2C+D%3BYang%2C+S+X&rft.aulast=Tan&rft.aufirst=A&rft.date=2008-01-01&rft.volume=19&rft.issue=1&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Annals+of+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Metastases; Exanthema; MAP kinase; Skin; Growth factor receptors; AKT protein; Breast cancer; Biopsy; Epidermal growth factor receptors; Toxicity; Immunohistochemistry; Side effects ER - TY - JOUR T1 - Isolation and Characterization of Broadly Neutralizing Human Monoclonal Antibodies to the E1 Glycoprotein of Hepatitis C Virus AN - 20469665; 7936522 AB - The relative importance of humoral and cellular immunity in the prevention or clearance of hepatitis C virus (HCV) infection is poorly understood. However, there is considerable evidence that neutralizing antibodies are involved in disease control. Here we describe the detailed analysis of human monoclonal antibodies (MAbs) directed against HCV glycoprotein E1, which may have the potential to control HCV infection. We have identified two MAbs that can strongly neutralize HCV-pseudotyped particles (HCVpp) bearing the envelope glycoproteins of genotypes 1a, 1b, 4a, 5a, and 6a and less strongly neutralize HCVpp bearing the envelope glycoproteins of genotype 2a. Genotype 3a was not neutralized. The epitopes for both MAbs were mapped to the region encompassing amino acids 313 to 327. In addition, robust neutralization was also observed against cell culture-adapted viruses of genotypes 1a and 2a. Results from this study suggest that these MAbs may have the potential to prevent HCV infection. JF - Journal of Virology AU - Meunier, Jean-Christophe AU - Russell, Rodney S AU - Goossens, Vera AU - Priem, Sofie AU - Walter, Hugo AU - Depla, Erik AU - Union, Ann AU - Faulk, Kristina N AU - Bukh, Jens AU - Emerson, Suzanne U AU - Purcell, Robert H AD - Hepatitis Viruses and Molecular Hepatitis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. GENimmune, Ghent, Belgium. Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre. Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 966 EP - 973 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 82 IS - 2 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Envelopes KW - Amino acids KW - Hepatitis C virus KW - Immunity (cell-mediated) KW - Monoclonal antibodies KW - Disease control KW - glycoprotein E1 KW - Genotypes KW - Glycoproteins KW - Infection KW - Epitopes KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20469665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Isolation+and+Characterization+of+Broadly+Neutralizing+Human+Monoclonal+Antibodies+to+the+E1+Glycoprotein+of+Hepatitis+C+Virus&rft.au=Meunier%2C+Jean-Christophe%3BRussell%2C+Rodney+S%3BGoossens%2C+Vera%3BPriem%2C+Sofie%3BWalter%2C+Hugo%3BDepla%2C+Erik%3BUnion%2C+Ann%3BFaulk%2C+Kristina+N%3BBukh%2C+Jens%3BEmerson%2C+Suzanne+U%3BPurcell%2C+Robert+H&rft.aulast=Meunier&rft.aufirst=Jean-Christophe&rft.date=2008-01-01&rft.volume=82&rft.issue=2&rft.spage=966&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amino acids; Envelopes; Immunity (cell-mediated); Monoclonal antibodies; Disease control; glycoprotein E1; Glycoproteins; Genotypes; Infection; Epitopes; Hepatitis C virus ER - TY - JOUR T1 - Nanotechnology Safety Concerns Revisited AN - 20469233; 7938188 AB - Nanotechnology is an emerging science involving manipulation of matter at the nanometer scale. Due to concerns over nanomaterial risks, there has been a dramatic increase in focused safety research. The present review provides a summary of these published findings, identifying areas of agreement and discordance with regard to: (1) the potential for nanomaterial exposure, (2) the relative hazard nanomaterials pose to humans and the environment, and (3) the present deficits in our understanding of risk. Special attention is paid to study design and methodologies, offering valuable insight into the complexities encountered with nanomaterial safety assessment. Recent data highlight the impact of surface characteristics on nanomaterial biocompatibility and point to the inadequacy of the current size-dependent mechanistic paradigms, with nanoscale materials lacking unique or characteristic toxicity profiles. The available data support the ability of the lung, gastrointestinal tract, and skin to act as a significant barrier to the systemic exposure of many nanomaterials. Furthermore, the acute systemic toxicity of many nanomaterials appear to be low. By contrast, the potential pulmonary toxicity of certain nanomaterials, such as carbon nanotubes, is significant, requiring a better understanding of exposure to further evaluate their risk. While these findings arrive at an overall picture of material-specific rather than nanogeneralized risk, any conclusions should clearly be tempered by the fact that nanomaterial safety data are limited. Until such time as the exposures, hazards, and environmental life cycle of nanomaterials have been more clearly defined, cautious development and implementation of nanotechnology is the most prudent course. JF - Toxicological Sciences AU - Stern, Stephan T AU - McNeil, Scott E AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 4 EP - 21 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 101 IS - 1 SN - 1096-6080, 1096-6080 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - acute toxicity KW - Biocompatibility KW - Skin KW - Life cycle KW - Toxicity KW - safety engineering KW - Carbon KW - life cycle KW - Lung KW - Reviews KW - Discordance KW - nanotubes KW - Gastrointestinal tract KW - nanotechnology KW - H 14000:Toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20469233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Nanotechnology+Safety+Concerns+Revisited&rft.au=Stern%2C+Stephan+T%3BMcNeil%2C+Scott+E&rft.aulast=Stern&rft.aufirst=Stephan&rft.date=2008-01-01&rft.volume=101&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biocompatibility; Skin; Carbon; Lung; Reviews; Discordance; nanotubes; Life cycle; Gastrointestinal tract; Toxicity; nanotechnology; acute toxicity; safety engineering; life cycle ER - TY - JOUR T1 - The PPAR alpha -Humanized Mouse: A Model to Investigate Species Differences in Liver Toxicity Mediated by PPAR alpha AN - 20450690; 7938178 AB - To determine the impact of the species difference between rodents and humans in response to peroxisome proliferators (PPs) mediated by peroxisome proliferator-activated receptor (PPAR) alpha , PPAR alpha -humanized transgenic mice were generated using a P1 phage artificial chromosome (PAC) genomic clone bred onto a ppar alpha -null mouse background, designated hPPAR alpha super(PAC). In hPPAR alpha super(PAC) mice, the human PPAR alpha gene is expressed in tissues with high fatty acid catabolism and induced upon fasting, similar to mouse PPAR alpha in wild-type (Wt) mice. Upon treatment with the PP fenofibrate, hPPAR alpha super(PAC) mice exhibited responses similar to Wt mice, including peroxisome proliferation, lowering of serum triglycerides, and induction of PPAR alpha target genes encoding enzymes involved in fatty acid metabolism in liver, kidney, and heart, suggesting that human PPAR alpha (hPPAR alpha ) functions in the same manner as mouse PPAR alpha in regulating fatty acid metabolism and lowering serum triglycerides. However, in contrast to Wt mice, treatment of hPPAR alpha super(PAC) mice with fenofibrate did not cause significant hepatomegaly and hepatocyte proliferation, thus indicating that the mechanisms by which PPAR alpha affects lipid metabolism are distinct from the hepatocyte proliferation response, the latter of which is only induced by mouse PPAR alpha . In addition, a differential regulation of several genes, including the oncogenic let-7C miRNA by PPs, was observed between Wt and hPPAR alpha super(PAC) mice that may contribute to the inherent difference between mouse and human PPAR alpha in activation of hepatocellular proliferation. The hPPAR alpha super(PAC) mouse model provides an in vivo platform to investigate the species difference mediated by PPAR alpha and an ideal model for human risk assessment PPs exposure. JF - Toxicological Sciences AU - Yang, Qian AU - Nagano, Tomokazu AU - Shah, Yatrik AU - Cheung, Connie AU - Ito, Shinji AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 132 EP - 139 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 101 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Phages KW - Heart KW - Risk assessment KW - Fenofibrate KW - Peroxisome proliferator-activated receptors KW - Hepatocytes KW - miRNA KW - Animal models KW - Enzymes KW - Transcription KW - Toxicity KW - Fasting KW - Transgenic mice KW - Lipid metabolism KW - Chromosomes KW - Gene regulation KW - Triglycerides KW - Liver KW - Fatty acids KW - Kidney KW - genomics KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20450690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=The+PPAR+alpha+-Humanized+Mouse%3A+A+Model+to+Investigate+Species+Differences+in+Liver+Toxicity+Mediated+by+PPAR+alpha&rft.au=Yang%2C+Qian%3BNagano%2C+Tomokazu%3BShah%2C+Yatrik%3BCheung%2C+Connie%3BIto%2C+Shinji%3BGonzalez%2C+Frank+J&rft.aulast=Yang&rft.aufirst=Qian&rft.date=2008-01-01&rft.volume=101&rft.issue=1&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Heart; Phages; Peroxisome proliferator-activated receptors; Fenofibrate; Hepatocytes; miRNA; Animal models; Transcription; Enzymes; Fasting; Toxicity; Transgenic mice; Lipid metabolism; Chromosomes; Triglycerides; Gene regulation; Kidney; Fatty acids; Liver; genomics ER - TY - JOUR T1 - Adaptive Postprocessing Techniques for Myocardial Tissue Tracking with Displacement-encoded MR Imaging AN - 20449148; 7937822 AB - The purpose of this study was to prospectively assess the effects of two adaptive postprocessing techniques on the evaluation of myocardial function with displacement-encoded magnetic resonance (MR) imaging, including sensitivity for abnormal wall motion, with two-dimensional echocardiography as the reference standard. Sixteen patients (11 men, five women; age range, 26-74 years) and 12 volunteers (six men, six women; age range, 29-53 years) underwent breath-hold MR imaging. Institutional review board approval and informed consent were obtained. Adaptive phase-unwrapping and spatial filtering techniques were compared with conventional phase-unwrapping and spatial filtering techniques. Use of the adaptive techniques led to a reduced rate of failure with the phase-unwrapping technique from 18.9% to 0.6% (P < .001), resulted in lower variability of segmental strain measurements among healthy volunteers (P < .001 to P = .02), and increased the sensitivity of quantitative detection of abnormal segments in patients from 82.5% to 87.7% (P = .034). The adaptive techniques improved the semiautomated postprocessing of displacement-encoded cardiac images and increased the sensitivity of detection of abnormal wall motion in patients. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/246/1/229/DC1 [copy ] RSNA, 2008 JF - Radiology AU - Wen, Han AU - Marsolo, Keith A AU - Bennett, Eric E AU - Kutten, Kwame S AU - Lewis, Ryan P AU - Lipps, David B AU - Epstein, Neal D AU - Plehn, Jonathan F AU - Croisille, Pierre AD - National Heart, Lung and Blood Institute, National Institutes of Health, Bldg 10, B1D416, 10 Center Dr, Bethesda, MD 20892 (H.W., E.E.B., R.P.L., N.D.E.) Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 229 EP - 240 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 246 IS - 1 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Age KW - Magnetic resonance imaging KW - Echocardiography KW - Computed tomography KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20449148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Adaptive+Postprocessing+Techniques+for+Myocardial+Tissue+Tracking+with+Displacement-encoded+MR+Imaging&rft.au=Wen%2C+Han%3BMarsolo%2C+Keith+A%3BBennett%2C+Eric+E%3BKutten%2C+Kwame+S%3BLewis%2C+Ryan+P%3BLipps%2C+David+B%3BEpstein%2C+Neal+D%3BPlehn%2C+Jonathan+F%3BCroisille%2C+Pierre&rft.aulast=Wen&rft.aufirst=Han&rft.date=2008-01-01&rft.volume=246&rft.issue=1&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Age; Computed tomography; Echocardiography; Magnetic resonance imaging ER - TY - JOUR T1 - Perceived Risk and Other Predictors and Correlates of Teenagers' Safety Belt Use During the First Year of Licensure AN - 20374713; 9053993 AB - Objectives. Teenagers have the lowest rate of safety belt use and the highest crash rate compared to other age groups. Past studies on teenagers' belt use have mostly been cross-sectional. The first goals of this study were to examine, at licensure, teenagers' and parents' perceptions of risk of crash/injury for newly licensed teenagers when driving unbelted and teenagers' perceived and parents' intended consequences for safety belt rule violations. In addition, the comparability of these variables to other risky driving behaviors was explored. The second goal was to evaluate the importance of these variables in the prediction of teenagers' belt use during the first year of licensure, relative to other factors related to belt use, including demographics and substance use. Methods. More than 2,000 parent-teenager dyads were interviewed by telephone, parents at permit and licensure and teenagers at permit, licensure, and 3, 6, and 12 months after licensure. Results. Approximately a third of the teenagers reported at least once at 3, 6, or 12 months post-licensure not always using their safety belt in the past week. At licensure, participants' perceived risk of safety belt non-use was high and ranked among the behaviors most related to crash/injury for newly licensed teenagers, behind driving under the influence of alcohol or drugs. Parent-imposed consequences for safety belt rule violations were not as highly rated as parent-imposed consequences for driving under the influence of alcohol or drugs. Sequential logistic regression modeled the relationship between safety belt use and perceived risk and consequences of non-use, as well as other prospective predictors assessed at permit and licensure, and driving correlates measured after licensure. Teenagers' extreme perceived risk and parents' intended sure consequences for non-use were significant prospective predictors of regular use during the first year of licensure. Other significant predictors and correlates were race (White), high school grade average of "A", not smoking cigarettes, driving a passenger vehicle, and never receiving a traffic citation or engaging in risky driving behaviors, including driving under the influence of alcohol or drugs and running a red light. Conclusions. While the effect size was small for perceived risk of non-use, it is a modifiable factor and focused intervention contrived to enhance perceived risk could increase teenagers' belt use. Perceived risk is discussed as a target for intervention in relation to the Protection Motivation Theory. This theory appears helpful in guiding future research into the modifiable factors studied here as well as other factors, including perceived rewards and costs associated with non-use. JF - Traffic Injury Prevention AU - Ouimet, M C AU - Morton, B S AU - Noelcke, E A AU - Williams, A F AU - Leaf, WA AU - Preusser, D F AU - Hartos, J L AD - Prevention Research Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 1 EP - 10 VL - 9 IS - 1 SN - 1538-9588, 1538-9588 KW - Risk Abstracts; Health & Safety Science Abstracts KW - demography KW - age groups KW - Alcohol KW - Cigarettes KW - Injuries KW - substance use KW - Drug abuse KW - traffic KW - driving ability KW - Perception KW - intervention KW - prevention KW - Drugs KW - Adolescents KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20374713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic+Injury+Prevention&rft.atitle=Perceived+Risk+and+Other+Predictors+and+Correlates+of+Teenagers%27+Safety+Belt+Use+During+the+First+Year+of+Licensure&rft.au=Ouimet%2C+M+C%3BMorton%2C+B+S%3BNoelcke%2C+E+A%3BWilliams%2C+A+F%3BLeaf%2C+WA%3BPreusser%2C+D+F%3BHartos%2C+J+L&rft.aulast=Ouimet&rft.aufirst=M&rft.date=2008-01-01&rft.volume=9&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Traffic+Injury+Prevention&rft.issn=15389588&rft_id=info:doi/10.1080%2F15389580701638793 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - demography; Alcohol; age groups; Injuries; Cigarettes; substance use; Drug abuse; traffic; Perception; driving ability; intervention; prevention; Drugs; Adolescents DO - http://dx.doi.org/10.1080/15389580701638793 ER - TY - JOUR T1 - AI-2-dependent gene regulation in Staphylococcus epidermidis AN - 20361046; 9027394 AB - Background Autoinducer 2 (AI-2), a widespread by-product of the LuxS-catalyzed S-ribosylhomocysteine cleavage reaction in the activated methyl cycle, has been suggested to serve as an intra- and interspecies signaling molecule, but in many bacteria AI-2 control of gene expression is not completely understood. Particularly, we have a lack of knowledge about AI-2 signaling in the important human pathogens Staphylococcus aureus and S. epidermidis. Results To determine the role of LuxS and AI-2 in S. epidermidis, we analyzed genome-wide changes in gene expression in an S. epidermidis luxS mutant and after addition of AI-2 synthesized by over-expressed S. epidermidis Pfs and LuxS enzymes. Genes under AI-2 control included mostly genes involved in sugar, nucleotide, amino acid, and nitrogen metabolism, but also virulence-associated genes coding for lipase and bacterial apoptosis proteins. In addition, we demonstrate by liquid chromatography/mass-spectrometry of culture filtrates that the pro-inflammatory phenol-soluble modulin (PSM) peptides, key virulence factors of S. epidermidis, are under luxS/AI-2 control. Conclusion Our results provide a detailed molecular basis for the role of LuxS in S. epidermidis virulence and suggest a signaling function for AI-2 in this bacterium. JF - BMC Microbiology AU - Li, Min AU - Villaruz, Amer E AU - Vadyvaloo, Viveka AU - Sturdevant, Daniel E AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, MT 59840, USA, limin2@niaid.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 4 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Sugar KW - Amino acids KW - LuxS protein KW - Apoptosis KW - virulence factors KW - Enzymes KW - Pathogens KW - Nucleotides KW - Inflammation KW - Triacylglycerol lipase KW - Liquid chromatography KW - Gene regulation KW - Staphylococcus aureus KW - Staphylococcus epidermidis KW - Metabolism KW - N-octanoylhomoserine lactone KW - Nitrogen KW - Signal transduction KW - J 02320:Cell Biology KW - N 14845:Miscellaneous KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20361046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Microbiology&rft.atitle=AI-2-dependent+gene+regulation+in+Staphylococcus+epidermidis&rft.au=Li%2C+Min%3BVillaruz%2C+Amer+E%3BVadyvaloo%2C+Viveka%3BSturdevant%2C+Daniel+E%3BOtto%2C+Michael&rft.aulast=Li&rft.aufirst=Min&rft.date=2008-01-01&rft.volume=8&rft.issue=&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=BMC+Microbiology&rft.issn=1471-2180&rft_id=info:doi/10.1186%2F1471-2180-8-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sugar; Apoptosis; LuxS protein; Amino acids; virulence factors; Enzymes; Pathogens; Nucleotides; Inflammation; Triacylglycerol lipase; Liquid chromatography; Gene regulation; N-octanoylhomoserine lactone; Metabolism; Signal transduction; Nitrogen; Staphylococcus aureus; Staphylococcus epidermidis DO - http://dx.doi.org/10.1186/1471-2180-8-4 ER - TY - JOUR T1 - A prospective study of physical activity and the risk of pancreatic cancer among women (United States) AN - 20354160; 9029602 AB - Background Several epidemiologic studies have examined the association between physical activity and pancreatic cancer risk; however, the results of these studies are not consistent. Methods This study examined the associations of total, moderate, and vigorous physical activity to pancreatic cancer in a cohort of 33,530 U.S. women enrolled in the Breast Cancer Detection Demonstration Project (BCDDP). At baseline (1987-1989), information on physical activity over the past year was obtained using a self-administered questionnaire. Cox proportional hazards regression was used to estimate relative risks (RR) and 95% confidence intervals of pancreatic cancer risk. Results 70 incident cases of pancreatic cancer were ascertained during 284,639 person years of follow-up between 1987-1989 and 1995-1998. After adjustment for age, body mass index, smoking status, history of diabetes, and height, increased physical activity was related to a suggestively decreased risk of pancreatic cancer. The RRs for increasing quartiles of total physical activity were 1.0, 0.80, 0.66, 0.52 (95% CI = 0.26, 1.05; p sub(trend )= 0.05). This association was consistent across subgroups defined by body mass index and smoking status. We also observed statistically non-significant reductions in pancreatic cancer risk for women in the highest quartile of moderate (RR = 0.57; 95% CI = 0.26, 1.26) and highest quartile of vigorous physical activity (RR = 0.63; 95% CI = 0.31, 1.28) compared to their least active counterparts. Conclusion Our study provides evidence for a role of physical activity in protecting against pancreatic cancer. JF - BMC Cancer AU - Calton, Brook A AU - Stolzenberg-Solomon, Rachael Z AU - Moore, Steven C AU - Schatzkin, Arthur AU - Schairer, Catherine AU - Albanes, Demetrius AU - Leitzmann, Michael F AD - Division of Cancer Epidemiology and Genetics, NCI/NIH, Rockville, MD, USA, brook.calton@ucsf.edu Y1 - 2008 PY - 2008 DA - 2008 SP - 63 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Physical Education Index KW - Smoking KW - Statistics KW - Body mass KW - Women KW - Height KW - Breasts KW - Exercise KW - Cancer KW - Diabetes KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20354160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Cancer&rft.atitle=A+prospective+study+of+physical+activity+and+the+risk+of+pancreatic+cancer+among+women+%28United+States%29&rft.au=Calton%2C+Brook+A%3BStolzenberg-Solomon%2C+Rachael+Z%3BMoore%2C+Steven+C%3BSchatzkin%2C+Arthur%3BSchairer%2C+Catherine%3BAlbanes%2C+Demetrius%3BLeitzmann%2C+Michael+F&rft.aulast=Calton&rft.aufirst=Brook&rft.date=2008-01-01&rft.volume=8&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=BMC+Cancer&rft.issn=1471-2407&rft_id=info:doi/10.1186%2F1471-2407-8-63 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Statistics; Body mass; Women; Height; Breasts; Exercise; Cancer; Diabetes DO - http://dx.doi.org/10.1186/1471-2407-8-63 ER - TY - JOUR T1 - Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression AN - 20350505; 9028677 AB - Background Secretoglobin (SCGB) 3A1 is a secretory protein of small molecular weight with tumor suppressor function. It is highly expressed in lung and trachea in both human and mouse, with additional tissues expressing the protein that differ depending on the species. However, little is known about the function and transcriptional regulation of this gene in normal mouse tissues. Results By reporter gene transfection and gel mobility shift analyses, we demonstrated that expression of the mouse Scgb3a1 gene is regulated by a PU-box binding protein and a ubiquitous transcription factor NF-Y that respectively binds to the PU-boxes located at -99 to -105 bp and -158 to -164 bp, and the "CCAAT" binding sites located at -425 to -429 bp and -498 to -502 bp from the transcription start site of the gene. However, the effect of PU-box binding protein on transcriptional activation is minimal as compared to NF-Y, suggesting that NF-Y is a more critical transcription factor for mouse Scgb3a1 gene transcription. Despite that NF-Y is a ubiquitous factor, Scgb3a1 is highly expressed only in mouse lung and mtCC cells that are derived from SV40 transformed mouse Clara cells, but not in ten other mouse tissues/cells examined. Gene methylation analysis revealed that within 600 bp of the Scgb3a1 gene promoter region, there are nine CpG methylation sites present, of which two CpGs closest to the transcription start site of the gene are unmethylated in the tissues/cells expressing SCGB3A1. Conclusion A ubiquitous transcription factor NF-Y binds to and activates expression of the mouse Scgb3a1 gene and tissue-specific expression of the gene is associated with CpG methylation of the promoter. JF - BMC Molecular Biology AU - Tomita, Takeshi AU - Kimura, Shioko AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA, tomitat@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 5 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Tumor suppressor genes KW - Transcription KW - CpG islands KW - Electrophoretic mobility KW - Gene expression KW - Promoters KW - Transfection KW - Lung KW - Reporter gene KW - Molecular weight KW - Gene regulation KW - Transcription factors KW - Simian virus 40 KW - DNA methylation KW - Trachea KW - Transcription activation KW - W 30905:Medical Applications KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20350505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Molecular+Biology&rft.atitle=Regulation+of+mouse+Scgb3a1+gene+expression+by+NF-Y+and+association+of+CpG+methylation+with+its+tissue-specific+expression&rft.au=Tomita%2C+Takeshi%3BKimura%2C+Shioko&rft.aulast=Tomita&rft.aufirst=Takeshi&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=BMC+Molecular+Biology&rft.issn=1471-2199&rft_id=info:doi/10.1186%2F1471-2199-9-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Transcription; CpG islands; Electrophoretic mobility; Gene expression; Promoters; Reporter gene; Lung; Transfection; Transcription factors; Gene regulation; Molecular weight; DNA methylation; Trachea; Transcription activation; Simian virus 40 DO - http://dx.doi.org/10.1186/1471-2199-9-5 ER - TY - JOUR T1 - Interrogating domain-domain interactions with parsimony based approaches AN - 20349862; 9023339 AB - Background The identification and characterization of interacting domain pairs is an important step towards understanding protein interactions. In the last few years, several methods to predict domain interactions have been proposed. Understanding the power and the limitations of these methods is key to the development of improved approaches and better understanding of the nature of these interactions. Results Building on the previously published Parsimonious Explanation method (PE) to predict domain-domain interactions, we introduced a new Generalized Parsimonious Explanation (GPE) method, which (i) adjusts the granularity of the domain definition to the granularity of the input data set and (ii) permits domain interactions to have different costs. This allowed for preferential selection of the so-called "co-occurring domains" as possible mediators of interactions between proteins. The performance of both variants of the parsimony method are competitive to the performance of the top algorithms for this problem even though parsimony methods use less information than some of the other methods. We also examined possible enrichment of co-occurring domains and homo-domains among domain interactions mediating the interaction of proteins in the network. The corresponding study was performed by surveying domain interactions predicted by the GPE method as well as by using a combinatorial counting approach independent of any prediction method. Our findings indicate that, while there is a considerable propensity towards these special domain pairs among predicted domain interactions, this overrepresentation is significantly lower than in the iPfam dataset. Conclusion The Generalized Parsimonious Explanation approach provides a new means to predict and study domain-domain interactions. We showed that, under the assumption that all protein interactions in the network are mediated by domain interactions, there exists a significant deviation of the properties of domain interactions mediating interactions in the network from that of iPfam data. JF - BMC Bioinformatics AU - Guimaraes, Katia S AU - Przytycka, Teresa M AD - National Center of Biotechnology, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, katiaguim@gmail.com Y1 - 2008 PY - 2008 DA - 2008 SP - 171 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Algorithms KW - Enumeration KW - Bioinformatics KW - Protein interaction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20349862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Interrogating+domain-domain+interactions+with+parsimony+based+approaches&rft.au=Guimaraes%2C+Katia+S%3BPrzytycka%2C+Teresa+M&rft.aulast=Guimaraes&rft.aufirst=Katia&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-171 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Algorithms; Bioinformatics; Enumeration; Protein interaction DO - http://dx.doi.org/10.1186/1471-2105-9-171 ER - TY - JOUR T1 - Towards an automatic classification of protein structural domains based on structural similarity AN - 20346661; 9023488 AB - Background Formal classification of a large collection of protein structures aids the understanding of evolutionary relationships among them. Classifications involving manual steps, such as SCOP and CATH, face the challenge of increasing volume of available structures. Automatic methods such as FSSP or Dali Domain Dictionary, yield divergent classifications, for reasons not yet fully investigated. One possible reason is that the pairwise similarity scores used in automatic classification do not adequately reflect the judgments made in manual classification. Another possibility is the difference between manual and automatic classification procedures. We explore the degree to which these two factors might affect the final classification. Results We use DALI, SHEBA and VAST pairwise scores on the SCOP C class domains, to investigate a variety of hierarchical clustering procedures. The constructed dendrogram is cut in a variety of ways to produce a partition, which is compared to the SCOP fold classification. Ward's method dendrograms led to partitions closest to the SCOP fold classification. Dendrogram- or tree-cutting strategies fell into four categories according to the similarity of resulting partitions to the SCOP fold partition. Two strategies which optimize similarity to SCOP, gave an average of 72% true positives rate (TPR), at a 1% false positive rate. Cutting the largest size cluster at each step gave an average of 61% TPR which was one of the best strategies not making use of prior knowledge of SCOP. Cutting the longest branch at each step produced one of the worst strategies. We also developed a method to detect irreducible differences between the best possible automatic partitions and SCOP, regardless of the cutting strategy. These differences are substantial. Visual examination of hard-to-classify proteins confirms our previous finding, that global structural similarity of domains is not the only criterion used in the SCOP classification. Conclusion Different clustering procedures give rise to different levels of agreement between automatic and manual protein classifications. None of the tested procedures completely eliminates the divergence between automatic and manual protein classifications. Achieving full agreement between these two approaches would apparently require additional information. JF - BMC Bioinformatics AU - Sam, Vichetra AU - Tai, Chin-Hsien AU - Garnier, Jean AU - Gibrat, Jean-Francois AU - Lee, Byungkook AU - Munson, Peter J AD - Mathematical and Statistical Computing Laboratory, DCB, CIT, NIH, DHHS, Bethesda, MD, USA, vsam@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 74 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Branches KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Towards+an+automatic+classification+of+protein+structural+domains+based+on+structural+similarity&rft.au=Sam%2C+Vichetra%3BTai%2C+Chin-Hsien%3BGarnier%2C+Jean%3BGibrat%2C+Jean-Francois%3BLee%2C+Byungkook%3BMunson%2C+Peter+J&rft.aulast=Sam&rft.aufirst=Vichetra&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-74 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein structure; Branches; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-9-74 ER - TY - JOUR T1 - Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition AN - 20343290; 9023906 AB - Background Human mast cell (HuMC) maturation occurs in tissues interfacing with the external environment, exposing both mast cell progenitors and mature mast cells, to bacteria and their products. It is unknown, however, whether long- or short-term exposure to bacteria-derived toll-like receptor (TLR) ligands, such as lipopolysaccharide (LPS) or peptidoglycan (PGN), influences HuMC biology. Results Over 6 wks of culture, LPS had minimal effect on HuMC numbers but increased CD117, tryptase and chymase expression. PGN inhibited HuMC development. For mature mast cells, LPS in the presence of rhSCF (10 ng/ml) increased CD117, tryptase, chymase and carboxypeptidase expression, primarily in CD117 super(low )HuMC. LPS decreased Fc epsilon RI expression and beta -hexosaminidase release; but had no effect on LTC sub(4 )and PGD sub(2 )production. PGN reduced HuMC numbers; and CD117 and tryptase expression. IL-1 beta and IL-6 (in addition to IL-8 and IL-12) were detected in short-term culture supernatants of LPS treated cells, and reproduced the increases in CD117, tryptase, chymase, and carboxypeptidase expression observed in the presence of LPS. Comparative studies with mouse bone marrow-derived mast cells from wild type, but not TLR4 knockout mice, showed increases in mRNA of mouse mast cell chymases MMCP-1, MMCP-2 and MMCP-4. Conclusion PGN inhibits HuMC growth, while LPS exerts its primary effects on mature HuMC by altering cytokine production and protease composition, particularly at low concentrations of SCF. These data demonstrate the ability of bacterial products to alter HuMC mediator production, granular content, and number which may be particularly relevant at mucosal sites where HuMC are exposed to these products. JF - BMC Immunology AU - Kirshenbaum, Arnold S AU - Swindle, Emily AU - Kulka, Marianna AU - Wu, Yalin AU - Metcalfe, Dean D AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, akirshenba@niaid.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 45 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Carboxypeptidase KW - Data processing KW - double prime Fc receptors KW - Mucosa KW - Interleukin 1 KW - Bone marrow KW - peptidoglycans KW - Mast cells KW - Cell culture KW - Tryptase KW - Development KW - Interleukin 8 KW - beta N- double prime Acetylhexosaminidase KW - mRNA KW - Interleukin 12 KW - Chymase KW - Stem cells KW - Cytokines KW - Lipopolysaccharides KW - Proteinase KW - TLR4 protein KW - Toll-like receptors KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20343290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Immunology&rft.atitle=Effect+of+lipopolysaccharide+%28LPS%29+and+peptidoglycan+%28PGN%29+on+human+mast+cell+numbers%2C+cytokine+production%2C+and+protease+composition&rft.au=Kirshenbaum%2C+Arnold+S%3BSwindle%2C+Emily%3BKulka%2C+Marianna%3BWu%2C+Yalin%3BMetcalfe%2C+Dean+D&rft.aulast=Kirshenbaum&rft.aufirst=Arnold&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=BMC+Immunology&rft.issn=1471-2172&rft_id=info:doi/10.1186%2F1471-2172-9-45 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Data processing; Carboxypeptidase; double prime Fc receptors; Interleukin 1; Mucosa; Bone marrow; Mast cells; peptidoglycans; Cell culture; Development; Tryptase; Interleukin 8; mRNA; beta N- double prime Acetylhexosaminidase; Chymase; Interleukin 12; Stem cells; Lipopolysaccharides; Cytokines; Proteinase; TLR4 protein; Toll-like receptors DO - http://dx.doi.org/10.1186/1471-2172-9-45 ER - TY - JOUR T1 - Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions AN - 20342920; 9023317 AB - Background The risk of common diseases is likely determined by the complex interplay between environmental and genetic factors, including single nucleotide polymorphisms (SNPs). Traditional methods of data analysis are poorly suited for detecting complex interactions due to sparseness of data in high dimensions, which often occurs when data are available for a large number of SNPs for a relatively small number of samples. Validation of associations observed using multiple methods should be implemented to minimize likelihood of false-positive associations. Moreover, high-throughput genotyping methods allow investigators to genotype thousands of SNPs at one time. Investigating associations for each individual SNP or interactions between SNPs using traditional approaches is inefficient and prone to false positives. Results We developed the Polymorphism Interaction Analysis tool (PIA version 2.0) to include different approaches for ranking and scoring SNP combinations, to account for imbalances between case and control ratios, stratify on particular factors, and examine associations of user-defined pathways (based on SNP or gene) with case status. PIA v. 2.0 detected 2-SNP interactions as the highest ranking model 77% of the time, using simulated data sets of genetic models of interaction (minor allele frequency = 0.2; heritability = 0.01; N = 1600) generated previously [Velez DR, White BC, Motsinger AA, Bush WS, Ritchie MD, Williams SM, Moore JH: A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol 2007, 31:306-315.]. Interacting SNPs were detected in both balanced (20 SNPs) and imbalanced data (case:control 1:2 and 1:4, 10 SNPs) in the context of non-interacting SNPs. Conclusion PIA v. 2.0 is a useful tool for exploring gene*gene or gene*environment interactions and identifying a small number of putative associations which may be investigated further using other statistical methods and in replication study populations. JF - BMC Bioinformatics AU - Mechanic, Leah E AU - Luke, Brian T AU - Goodman, Julie E AU - Chanock, Stephen J AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA, mechanil@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 146 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genetic factors KW - Statistics KW - Data processing KW - Replication KW - Genotyping KW - Gene polymorphism KW - Population studies KW - Models KW - Single-nucleotide polymorphism KW - Epistasis KW - Bushes KW - Gene frequency KW - Bioinformatics KW - Heritability KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20342920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Polymorphism+Interaction+Analysis+%28PIA%29%3A+a+method+for+investigating+complex+gene-gene+interactions&rft.au=Mechanic%2C+Leah+E%3BLuke%2C+Brian+T%3BGoodman%2C+Julie+E%3BChanock%2C+Stephen+J%3BHarris%2C+Curtis+C&rft.aulast=Mechanic&rft.aufirst=Leah&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-146 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genetic factors; Data processing; Statistics; Replication; Gene polymorphism; Genotyping; Population studies; Models; Single-nucleotide polymorphism; Epistasis; Bushes; Gene frequency; Bioinformatics; Heritability DO - http://dx.doi.org/10.1186/1471-2105-9-146 ER - TY - JOUR T1 - catmap: C ase-control A nd T DT M eta- A nalysis P ackage AN - 20342457; 9023301 AB - Background Risk for complex disease is thought to be controlled by multiple genetic risk factors, each with small individual effects. Meta-analyses of several independent studies may be helpful to increase the ability to detect association when effect sizes are modest. Although many software options are available for meta-analysis of genetic case-control data, no currently available software implements the method described by Kazeem and Farrall (2005), which combines data from independent family-based and case-control studies. Results I introduce the package catmap for the R statistical computing environment that implements fixed- and random-effects pooled estimates for case-control and transmission disequilibrium methods, allowing for the use of genetic association data across study types. In addition, catmap may be used to create forest and funnel plots and to perform sensitivity analysis and cumulative meta-analysis. catmap is available from the Comprehensive R Archive Network . Conclusion catmap allows researchers to synthesize data to assess evidence for association in studies of genetic polymorphisms, facilitating the use of pooled data analyses which may increase power to detect moderate genetic associations. JF - BMC Bioinformatics AU - Nicodemus, Kristin K AD - Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA, kristin.nicodemus@well.ox.ac.uk Y1 - 2008 PY - 2008 DA - 2008 SP - 130 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Data processing KW - Statistics KW - Reviews KW - Gene polymorphism KW - Risk factors KW - Forests KW - Bioinformatics KW - Disease transmission KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20342457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=catmap%3A+C+ase-control+A+nd+T+DT+M+eta-+A+nalysis+P+ackage&rft.au=Nicodemus%2C+Kristin+K&rft.aulast=Nicodemus&rft.aufirst=Kristin&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-130 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Statistics; Data processing; Risk factors; Gene polymorphism; Reviews; Forests; Bioinformatics; Disease transmission DO - http://dx.doi.org/10.1186/1471-2105-9-130 ER - TY - JOUR T1 - Examining the significance of fingerprint-based classifiers AN - 20338764; 9014823 AB - Background Experimental examinations of biofluids to measure concentrations of proteins or their fragments or metabolites are being explored as a means of early disease detection, distinguishing diseases with similar symptoms, and drug treatment efficacy. Many studies have produced classifiers with a high sensitivity and specificity, and it has been argued that accurate results necessarily imply some underlying biology-based features in the classifier. The simplest test of this conjecture is to examine datasets designed to contain no information with classifiers used in many published studies. Results The classification accuracy of two fingerprint-based classifiers, a decision tree (DT) algorithm and a medoid classification algorithm (MCA), are examined. These methods are used to examine 30 artificial datasets that contain random concentration levels for 300 biomolecules. Each dataset contains between 30 and 300 Cases and Controls, and since the 300 observed concentrations are randomly generated, these datasets are constructed to contain no biological information. A modest search of decision trees containing at most seven decision nodes finds a large number of unique decision trees with an average sensitivity and specificity above 85% for datasets containing 60 Cases and 60 Controls or less, and for datasets with 90 Cases and 90 Controls many DTs have an average sensitivity and specificity above 80%. For even the largest dataset (300 Cases and 300 Controls) the MCA procedure finds several unique classifiers that have an average sensitivity and specificity above 88% using only six or seven features. Conclusion While it has been argued that accurate classification results must imply some biological basis for the separation of Cases from Controls, our results show that this is not necessarily true. The DT and MCA classifiers are sufficiently flexible and can produce good results from datasets that are specifically constructed to contain no information. This means that a chance fitting to the data is possible. All datasets used in this investigation are available on the web. This work is funded by NCI Contract N01-CO-12400. JF - BMC Bioinformatics AU - Luke, Brian T AU - Collins, Jack R AD - Advanced Biomedical Computing Center, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA, lukeb@ncifcrf.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 545 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Algorithms KW - Metabolites KW - Bioinformatics KW - Nodes KW - Drugs KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20338764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Examining+the+significance+of+fingerprint-based+classifiers&rft.au=Luke%2C+Brian+T%3BCollins%2C+Jack+R&rft.aulast=Luke&rft.aufirst=Brian&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-545 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Algorithms; Metabolites; Bioinformatics; Nodes; Drugs DO - http://dx.doi.org/10.1186/1471-2105-9-545 ER - TY - JOUR T1 - Chapter 1 Common Genetic Variation and Human Disease AN - 20336222; 9010821 AB - The landscape of human genetics has changed remarkably in a relatively short space of time. The field has progressed from comparatively small studies of rare genetic diseases to vast consortia based efforts that target the inherited components of common complex diseases and which typically involve thousands of individual samples. In particular, genome wide association studies have become possible as a result of a new generation of genotyping platforms. At the time of writing, these have led to the discovery of more than 150 novel susceptibility loci across a broad spectrum of diseases, a few in genes with high biological plausibility but the majority in others that had not been considered candidates. Here, we provide an overview of the field of complex disease genetics pertaining to mapping by association and consider the many pitfalls and caveats that have arisen. JF - Advanced Drug Delivery Reviews AU - Orr, Nick AU - Chanock, Stephen AD - Core Genotyping Facility, Advanced Technology Center, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008 PY - 2008 DA - 2008 SP - 1 EP - 32 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 62 SN - 0169-409X, 0169-409X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Drug delivery KW - Reviews KW - Genotyping KW - Landscape KW - Genetic diversity KW - Gene mapping KW - G 07880:Human Genetics KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20336222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Chapter+1+Common+Genetic+Variation+and+Human+Disease&rft.au=Orr%2C+Nick%3BChanock%2C+Stephen&rft.aulast=Orr&rft.aufirst=Nick&rft.date=2008-01-01&rft.volume=62&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2FS0065-2660%2808%2900601-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Drug delivery; Genotyping; Reviews; Landscape; Genetic diversity; Gene mapping DO - http://dx.doi.org/10.1016/S0065-2660(08)00601-9 ER - TY - JOUR T1 - Identifying differential correlation in gene/pathway combinations AN - 20325213; 9014798 AB - Background An important emerging trend in the analysis of microarray data is to incorporate known pathway information a priori. Expression level "summaries" for pathways, obtained from the expression data for the genes constituting the pathway, permit the inclusion of pathway information, reduce the high dimensionality of microarray data, and have the power to elucidate gene-interaction dependencies which are not already accounted for through known pathway identification. Results We present a novel method for the analysis of microarray data that identifies joint differential expression in gene-pathway pairs. This method takes advantage of known gene pathway memberships to compute a summary expression level for each pathway as a whole. Correlations between the pathway expression summary and the expression levels of genes not already known to be associated with the pathway provide clues to gene interaction dependencies that are not already accounted for through known pathway identification, and statistically significant differences between gene-pathway correlations in phenotypically different cells (e.g., where the expression level of a single gene and a given pathway summary correlate strongly in normal cells but weakly in tumor cells) may indicate biologically relevant gene-pathway interactions. Here, we detail the methodology and present the results of this method applied to two gene-expression datasets, identifying gene-pathway pairs which exhibit differential joint expression by phenotype. Conclusion The method described herein provides a means by which interactions between large numbers of genes may be identified by incorporating known pathway information to reduce the dimensionality of gene interactions. The method is efficient and easily applied to data sets of ~10 super(2 )arrays. Application of this method to two publicly-available cancer data sets yields suggestive and promising results. This method has the potential to complement gene-at-a-time analysis techniques for microarray analysis by indicating relationships between pathways and genes that have not previously been identified and which may play a role in disease. JF - BMC Bioinformatics AU - Braun, Rosemary AU - Cope, Leslie AU - Parmigiani, Giovanni AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, braunr@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 488 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - Statistical analysis KW - Bioinformatics KW - Tumor cells KW - Cancer KW - Joints KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20325213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Identifying+differential+correlation+in+gene%2Fpathway+combinations&rft.au=Braun%2C+Rosemary%3BCope%2C+Leslie%3BParmigiani%2C+Giovanni&rft.aulast=Braun&rft.aufirst=Rosemary&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-488 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Statistical analysis; Bioinformatics; Tumor cells; Cancer; Joints DO - http://dx.doi.org/10.1186/1471-2105-9-488 ER - TY - JOUR T1 - Themes in biomedical natural language processing: BioNLP08 AN - 20309312; 8925689 JF - BMC Bioinformatics AU - Demner-Fushman, Dina AU - Ananiadou, Sophia AU - Cohen, K Bretonnel AU - Pestian, John AU - Tsujii, Jun'ichi AU - Webber, Bonnie AD - US National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA, ddemner@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S1 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 11 KW - Biotechnology and Bioengineering Abstracts KW - Language KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20309312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Themes+in+biomedical+natural+language+processing%3A+BioNLP08&rft.au=Demner-Fushman%2C+Dina%3BAnaniadou%2C+Sophia%3BCohen%2C+K+Bretonnel%3BPestian%2C+John%3BTsujii%2C+Jun%27ichi%3BWebber%2C+Bonnie&rft.aulast=Demner-Fushman&rft.aufirst=Dina&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+11&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S11-S1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Language; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-9-S11-S1 ER - TY - JOUR T1 - Automatic inference of indexing rules for MEDLINE AN - 20305966; 8925680 AB - Background: Indexing is a crucial step in any information retrieval system. In MEDLINE , a widely used database of the biomedical literature, the indexing process involves the selection of Medical Subject Headings in order to describe the subject matter of articles. The need for automatic tools to assist MEDLINE indexers in this task is growing with the increasing number of publications being added to MEDLINE . Methods: In this paper, we describe the use and the customization of Inductive Logic Programming (ILP) to infer indexing rules that may be used to produce automatic indexing recommendations for MEDLINE indexers. Results: Our results show that this original ILP-based approach outperforms manual rules when they exist. In addition, the use of ILP rules also improves the overall performance of the Medical Text Indexer ( MTI ), a system producing automatic indexing recommendations for MEDLINE . Conclusion: We expect the sets of ILP rules obtained in this experiment to be integrated into MTI . JF - BMC Bioinformatics AU - Neveol, Aurelie AU - Shooshan, Sonya E AU - Claveau, Vincent AD - National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA, neveola@nlm.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S11 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 11 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Information processing KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20305966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Automatic+inference+of+indexing+rules+for+MEDLINE&rft.au=Neveol%2C+Aurelie%3BShooshan%2C+Sonya+E%3BClaveau%2C+Vincent&rft.aulast=Neveol&rft.aufirst=Aurelie&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+11&rft.spage=S11&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S11-S11 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Information processing; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-9-S11-S11 ER - TY - JOUR T1 - Prospective study of physical activity and risk of postmenopausal breast cancer AN - 20270744; 8921933 AB - Introduction To prospectively examine the relation of total, vigorous and non-vigorous physical activity to postmenopausal breast cancer risk. Methods We studied 32,269 women enrolled in the Breast Cancer Detection Demonstration Project Follow-up Study. Usual physical activity (including household, occupational and leisure activities) throughout the previous year was assessed at baseline using a self-administered questionnaire. Postmenopausal breast cancer cases were identified through self-reports, death certificates and linkage to state cancer registries. A Cox proportional hazards regression was used to estimate the relative risk and 95% confidence intervals of postmenopausal breast cancer associated with physical activity. Results During 269,792 person-years of follow-up from 1987 to 1998, 1506 new incident cases of postmenopausal breast cancer were ascertained. After adjusting for potential risk factors of breast cancer, a weak inverse association between total physical activity and postmenopausal breast cancer was suggested (relative risk comparing extreme quintiles = 0.87; 95% confidence interval = 0.74 to 1.02; p for trend = 0.21). That relation was almost entirely contributed by vigorous activity (relative risk comparing extreme categories = 0.87; 95% confidence interval = 0.74 to 1.02; p for trend = 0.08). The inverse association with vigorous activity was limited to women who were lean (ie, body mass index &25.0 kg/m super(2): relative risk = 0.68; 95% confidence interval = 0.54 to 0.85). In contrast, no association with vigorous activity was noted among women who were overweight or obese (ie, body mass index greater than or equal to 25.0 kg/m super(2): relative risk = 1.18; 95% confidence interval = 0.93 to 1.49; p for interaction = 0.008). Non-vigorous activity showed no relation to breast cancer (relative risk comparing extreme quintiles = 1.02; 95% confidence interval = 0.87 to 1.19; p for trend = 0.86). The physical activity and breast cancer relation was not specific to a certain hormone receptor subtype. Conclusions In this cohort of postmenopausal women, breast cancer risk reduction appeared to be limited to vigorous forms of activity; it was apparent among normal weight women but not overweight women, and the relation did not vary by hormone receptor status. Our findings suggest that physical activity acts through underlying biological mechanisms that are independent of body weight control. JF - Breast Cancer Research AU - Leitzmann, Michael F AU - Moore, Steven C AU - Peters, Tricia M AU - Lacey, James V AU - Schatzkin, Arthur AU - Schairer, Catherine AU - Brinton, Louise A AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 6120 Executive Blvd., MSC 7232, Bethesda, MD 20892, USA, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2008 PY - 2008 DA - 2008 SP - R92 PB - BioMed Central Ltd., Middlesex House VL - 10 IS - 5 SN - 1465-5411, 1465-5411 KW - Physical Education Index KW - Obesity KW - Body mass KW - Women KW - Breasts KW - Exercise KW - Activities KW - Trends KW - Hormones KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20270744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+Cancer+Research&rft.atitle=Prospective+study+of+physical+activity+and+risk+of+postmenopausal+breast+cancer&rft.au=Leitzmann%2C+Michael+F%3BMoore%2C+Steven+C%3BPeters%2C+Tricia+M%3BLacey%2C+James+V%3BSchatzkin%2C+Arthur%3BSchairer%2C+Catherine%3BBrinton%2C+Louise+A%3BAlbanes%2C+Demetrius&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=10&rft.issue=5&rft.spage=R92&rft.isbn=&rft.btitle=&rft.title=Breast+Cancer+Research&rft.issn=14655411&rft_id=info:doi/10.1186%2Fbcr2190 LA - English DB - Physical Education Index N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Body mass; Women; Breasts; Exercise; Trends; Activities; Hormones; Cancer DO - http://dx.doi.org/10.1186/bcr2190 ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 20214803; 8509537 AB - In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data available through NCBI's web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link, Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace, Assembly, and Short Read Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Database of Genotype and Phenotype, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting the web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. JF - Nucleic Acids Research AU - Wheeler, David L AU - Barrett, Tanya AU - Benson, Dennis A AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Edgar, Ron AU - Federhen, Scott AU - Feolo, Michael AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Khovayko, Oleg AU - Landsman, David AU - Lipman, David J AU - Madden, Thomas L AU - Maglott, Donna R AU - Miller, Vadim AU - Ostell, James AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Shumway, Martin AU - Sequeira, Edwin AU - Sherry, Steven T AU - Sirotkin, Karl AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusov, Roman L AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Yaschenko, Eugene AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA, wheeler@ncbi.nlm.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D13 EP - D21 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - DNA probes KW - Genotypes KW - Cancer KW - Gene expression KW - Influenza KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Taxonomy KW - Protein interaction KW - V 22360:AIDS and HIV KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20214803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Wheeler%2C+David+L%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BEdgar%2C+Ron%3BFederhen%2C+Scott%3BFeolo%2C+Michael%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BKhovayko%2C+Oleg%3BLandsman%2C+David%3BLipman%2C+David+J%3BMadden%2C+Thomas+L%3BMaglott%2C+Donna+R%3BMiller%2C+Vadim%3BOstell%2C+James%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BShumway%2C+Martin%3BSequeira%2C+Edwin%3BSherry%2C+Steven+T%3BSirotkin%2C+Karl%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusov%2C+Roman+L%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BYaschenko%2C+Eugene&rft.aulast=Wheeler&rft.aufirst=David&rft.date=2008-01-01&rft.volume=36&rft.issue=suppl_1&rft.spage=D13&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkm1000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; DNA probes; Genotypes; Cancer; Influenza; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Polymerase chain reaction; Taxonomy; Protein interaction; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1093/nar/gkm1000 ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 20191043; 8736485 AB - In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data available through NCBI's web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link, Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace, Assembly, and Short Read Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Database of Genotype and Phenotype, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting the web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov . JF - Nucleic Acids Research AU - Wheeler, David L AU - Barrett, Tanya AU - Benson, Dennis A AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Edgar, Ron AU - Federhen, Scott AU - Feolo, Michael AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Khovayko, Oleg AU - Landsman, David AU - Lipman, David J AU - Madden, Thomas L AU - Maglott, Donna R AU - Miller, Vadim AU - Ostell, James AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Shumway, Martin AU - Sequeira, Edwin AU - Sherry, Steven T AU - Sirotkin, Karl AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusov, Roman L AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Yaschenko, Eugene AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D13 EP - D21 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - Database issue SN - 0305-1048, 0305-1048 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - DNA probes KW - Genotypes KW - Cancer KW - Gene expression KW - Influenza KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Taxonomy KW - Protein interaction KW - V 22360:AIDS and HIV KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20191043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Wheeler%2C+David+L%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BEdgar%2C+Ron%3BFederhen%2C+Scott%3BFeolo%2C+Michael%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BKhovayko%2C+Oleg%3BLandsman%2C+David%3BLipman%2C+David+J%3BMadden%2C+Thomas+L%3BMaglott%2C+Donna+R%3BMiller%2C+Vadim%3BOstell%2C+James%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BShumway%2C+Martin%3BSequeira%2C+Edwin%3BSherry%2C+Steven+T%3BSirotkin%2C+Karl%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusov%2C+Roman+L%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BYaschenko%2C+Eugene&rft.aulast=Wheeler&rft.aufirst=David&rft.date=2008-01-01&rft.volume=36&rft.issue=Database+issue&rft.spage=D13&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkm1000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; DNA probes; Genotypes; Cancer; Influenza; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Polymerase chain reaction; Taxonomy; Protein interaction; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1093/nar/gkm1000 ER - TY - JOUR T1 - Differences in evolutionary pressure acting within highly conserved ortholog groups AN - 20114662; 8518771 AB - Background In highly conserved widely distributed ortholog groups, the main evolutionary force is assumed to be purifying selection that enforces sequence conservation, with most divergence occurring by accumulation of neutral substitutions. Using a set of ortholog groups from prokaryotes, with a single representative in each studied organism, we asked the question if this evolutionary pressure is acting similarly on different subgroups of orthologs defined as major lineages (e.g. Proteobacteria or Firmicutes). Results Using correlations in entropy measures as a proxy for evolutionary pressure, we observed two distinct behaviors within our ortholog collection. The first subset of ortholog groups, called here informational, consisted mostly of proteins associated with information processing (i.e. translation, transcription, DNA replication) and the second, the non-informational ortholog groups, mostly comprised of proteins involved in metabolic pathways. The evolutionary pressure acting on non-informational proteins is more uniform relative to their informational counterparts. The non-informational proteins show higher level of correlation between entropy profiles and more uniformity across subgroups. Conclusion The low correlation of entropy profiles in the informational ortholog groups suggest that the evolutionary pressure acting on the informational ortholog groups is not uniform across different clades considered this study. This might suggest "fine-tuning" of informational proteins in each lineage leading to lineage-specific differences in selection. This, in turn, could make these proteins less exchangeable between lineages. In contrast, the uniformity of the selective pressure acting on the non-informational groups might allow the exchange of the genetic material via lateral gene transfer. JF - BMC Evolutionary Biology AU - Przytycka, Teresa M AU - Jothi, Raja AU - Aravind, L AU - Lipman, David J AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, przytyck@ncbi.nlm.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 208 PB - BioMed Central Ltd., Middlesex House VL - 8 SN - 1471-2148, 1471-2148 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Translation KW - DNA biosynthesis KW - Replication KW - Transcription KW - Firmicutes KW - Proteobacteria KW - Gene transfer KW - Information processing KW - Metabolic pathways KW - Conserved sequence KW - Prokaryotes KW - Evolution KW - Entropy KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20114662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Evolutionary+Biology&rft.atitle=Differences+in+evolutionary+pressure+acting+within+highly+conserved+ortholog+groups&rft.au=Przytycka%2C+Teresa+M%3BJothi%2C+Raja%3BAravind%2C+L%3BLipman%2C+David+J&rft.aulast=Przytycka&rft.aufirst=Teresa&rft.date=2008-01-01&rft.volume=8&rft.issue=&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=BMC+Evolutionary+Biology&rft.issn=14712148&rft_id=info:doi/10.1186%2F1471-2148-8-208 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Translation; Gene transfer; Replication; Information processing; Metabolic pathways; Transcription; Conserved sequence; Prokaryotes; Entropy; Evolution; Firmicutes; Proteobacteria DO - http://dx.doi.org/10.1186/1471-2148-8-208 ER - TY - JOUR T1 - Nonmuscle myosin II moves in new directions AN - 20005361; 7936347 AB - For many years, analyses of the role of the actomyosin cytoskeleton in many basic cellular processes have centered on actin. Increasingly, however, a number of investigators are examining proteins that are proximal to actin; in particular, nonmuscle myosin II (NMII). Recent experiments have increased our understanding of the role of NMII in three related cellular activities: generation of cell polarity, cell migration and cell-cell adhesion. Progress has been particularly promising thanks to the use of new microscopic, genetic and biochemical techniques. In mammalian systems, generation of transgenic mice and the introduction of specific siRNAs have been useful in deciphering the role of the three different isoforms of NMII: NMIIA, NMIIB and NMIIC. Studies in Drosophila and Aplysia, which are informative model systems for investigating the function of NMII, have also shed light on NMII. Recent work examines the contractile and structural roles that NMII plays at cell-cell boundaries, and both its contractile and actin-crosslinking roles in cell migration. In addition, NMII might also function as a scaffold molecule, anchoring signaling molecules, such as kinases and Rho GTPase guanine nucleotide exchange factors. JF - Journal of Cell Science AU - Conti, Mary Anne AU - Adelstein, Robert S AD - Laboratory of Molecular Cardiology, Genetics and Developmental Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 11 EP - 18 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK, [URL:http://www.biologists.com/web/index.html] VL - 121 IS - 1 SN - 0021-9533, 0021-9533 KW - Entomology Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - actomyosin KW - Transgenic mice KW - Contractility KW - scaffolds KW - Aplysia KW - Cytoskeleton KW - Myosin KW - guanine nucleotide exchange factor KW - siRNA KW - Polarity KW - Actin KW - Cell migration KW - Drosophila KW - Signal transduction KW - Guanosinetriphosphatase KW - W 30925:Genetic Engineering KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20005361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Science&rft.atitle=Nonmuscle+myosin+II+moves+in+new+directions&rft.au=Conti%2C+Mary+Anne%3BAdelstein%2C+Robert+S&rft.aulast=Conti&rft.aufirst=Mary&rft.date=2008-01-01&rft.volume=121&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - actomyosin; Contractility; Transgenic mice; scaffolds; Cytoskeleton; Myosin; guanine nucleotide exchange factor; siRNA; Actin; Polarity; Cell migration; Guanosinetriphosphatase; Signal transduction; Drosophila; Aplysia ER - TY - JOUR T1 - Temporal Trends and Climatic Factors Associated with Bacterial Enteric Diseases in Vietnam, 1991-2001 AN - 19994638; 8044950 AB - Objective: In Vietnam, shigellosis/dysentery, typhoid fever, and cholera are important enteric diseases. To better understand their epidemiology, we determined temporal trends, seasonal patterns, and climatic factors associated with high risk periods in eight regions across Vietnam. Methods: We quantified monthly cases and incidence rates (IR) for each region from national surveillance data (1991-2001). High- and low-disease periods were defined from the highest and lowest IRs (1 SD above and below the mean) and from outbreaks from positive outliers (4 SDs higher in 1 month or 2 SDs higher in greater than or equal to 2 consecutive months). We used general linear models to compare precipitation, temperature, and humidity between high- and low-risk periods. RESULTS: Shigellosis/dysentery was widespread and increased 2.5 times during the study period, with the highest average IRs found between June and August (2.1/100,000-26.2/100,000). Typhoid fever was endemic in the Mekong River Delta and emerged in the Northwest in the mid-1990s, with peaks between April and August (0.38-8.6). Cholera was mostly epidemic along the central coast between May and November (0.07-2.7), and then decreased dramatically nationwide from 1997 onward. Significant climate differences, were found only between high- and low-disease periods. We were able to define 4 shigellosis/dysentery, 14 typhoid fever, and 8 cholera outbreaks, with minimal geotemporal overlap and no significant climatic associations. Conclusions: In Vietnam, bacterial enteric diseases have distinct temporal trends and seasonal patterns. Climate plays a role in defining high- and low-disease periods, but it does not appear to be an important factor influencing outbreaks. JF - Environmental Health Perspectives AU - Kelly-Hope, LA AU - Alonso, W J AU - Thiem, V D AU - Canh, D G AU - Ann, D D AU - Lee, H AU - Miller, MA AD - Division of International Epidemiology and Population Studies, Fogarty International Center, 16 Center Dr., National Institutes of Health, Bethesda, MD 20892 USA, kellyhopel@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 7 EP - 12 VL - 116 IS - 1 SN - 0091-6765, 0091-6765 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Sustainability Science Abstracts; Meteorological & Geoastrophysical Abstracts KW - ISEW, Vietnam KW - Rainfall KW - Models KW - ISEW, Vietnam, Mekong River Delta KW - Sulfur dioxide KW - Shigellosis KW - deltas KW - Risk factors KW - Risk groups KW - Cholera KW - Diseases KW - Typhoid fever KW - Seasonal variations KW - Coasts KW - Temperature effects KW - Rivers KW - Bacteria KW - Epidemics KW - Data processing KW - Climate KW - Temperature KW - Humidity KW - outbreaks KW - Precipitation KW - Epidemiology KW - Dysentery KW - dysentery KW - M3 1010:Issues in Sustainable Development KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02400:Human Diseases KW - M2 551.577:General Precipitation (551.577) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19994638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Temporal+Trends+and+Climatic+Factors+Associated+with+Bacterial+Enteric+Diseases+in+Vietnam%2C+1991-2001&rft.au=Kelly-Hope%2C+LA%3BAlonso%2C+W+J%3BThiem%2C+V+D%3BCanh%2C+D+G%3BAnn%2C+D+D%3BLee%2C+H%3BMiller%2C+MA&rft.aulast=Kelly-Hope&rft.aufirst=LA&rft.date=2008-01-01&rft.volume=116&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9658 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Rivers; Temperature effects; Data processing; Epidemics; Climate; Humidity; Precipitation; Models; Epidemiology; Dysentery; Shigellosis; Risk factors; Risk groups; Cholera; Typhoid fever; Seasonal variations; Coasts; Sulfur dioxide; Rainfall; deltas; Temperature; dysentery; outbreaks; Diseases; Bacteria; ISEW, Vietnam, Mekong River Delta; ISEW, Vietnam DO - http://dx.doi.org/10.1289/ehp.9658 ER - TY - JOUR T1 - Neutrophils Clear Bacteria Associated with Parasitic Nematodes Augmenting the Development of an Effective Th2-Type Response AN - 19993508; 7935875 AB - Infection with the parasitic nematode Nippostrongylus brasiliensis induces a potent Th2 response; however, little is known about early stages of the innate response that may contribute to protective immunity. To examine early events in this response, chemokine expression in the draining lymph node was examined after N. brasiliensis inoculation. Pronounced increases of several chemokines, including CCL2, were observed. Compared with wild-type mice, elevations in a Gr-1 super(bright) population in the draining lymph node was significantly decreased in CCL2 super(-/-) mice after N. brasiliensis inoculation. Further flow cytometric and immunofluorescent analysis showed that in wild-type mice, Gr-1 super(+) cells transiently entered and exited the draining lymph node shortly after N. brasiliensis inoculation. The Gr-1 super(bright) population was comprised of neutrophils expressing TGF- beta and TNF- alpha . Following Gr-1 super(+) cell depletion, N. brasiliensis infection resulted in transient, but significantly increased levels of IFN- gamma , increased serum IgG2a, reduced Th2 cytokines and serum IgE, greatly increased mortality, and delayed worm expulsion. Furthermore, bacteria were readily detected in vital organs. Infection of Gr-1 super(+) cell-depleted mice with N. brasiliensis larvae that were pretreated with antibiotics prevented bacterial dissemination, Th1 inflammatory responses, and decreases in host survival. This study indicates that parasitic nematodes can be an important vector of potentially harmful bacteria, which is typically controlled by CCL2-dependent neutrophils that ensure the optimal development of Th2 immune responses and parasite resistance. JF - Journal of Immunology AU - Pesce, John T AU - Liu, Zhugong AU - Hamed, Hossein AU - Alem, Farhang AU - Whitmire, Jeanette AU - Lin, Hongxia AU - Liu, Qian AU - Urban, Joseph FJr AU - Gause, William C AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Department of Medicine, New Jersey Medical School, University of Medicine & Dentistry of New Jersey, Newark, NJ 07101. Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Diet, Genomics, and Immunology Laboratory, Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, Beltsville, MD 20705 Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 464 EP - 474 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 1 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell survival KW - gamma -Interferon KW - Chemokines KW - Helper cells KW - Antibiotics KW - Infection KW - Flow cytometry KW - Nippostrongylus brasiliensis KW - Lymphocytes T KW - Cytokines KW - Nematoda KW - Mortality KW - Monocyte chemoattractant protein 1 KW - Larvae KW - Leukocytes (neutrophilic) KW - Parasite resistance KW - Lymph nodes KW - Inflammation KW - Immunoglobulin E KW - Transforming growth factor- beta KW - Inoculation KW - Immunoglobulin G KW - Tumor necrosis factor- alpha KW - Immune response KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19993508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Neutrophils+Clear+Bacteria+Associated+with+Parasitic+Nematodes+Augmenting+the+Development+of+an+Effective+Th2-Type+Response&rft.au=Pesce%2C+John+T%3BLiu%2C+Zhugong%3BHamed%2C+Hossein%3BAlem%2C+Farhang%3BWhitmire%2C+Jeanette%3BLin%2C+Hongxia%3BLiu%2C+Qian%3BUrban%2C+Joseph+FJr%3BGause%2C+William+C&rft.aulast=Pesce&rft.aufirst=John&rft.date=2008-01-01&rft.volume=180&rft.issue=1&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Mortality; gamma -Interferon; Chemokines; Monocyte chemoattractant protein 1; Helper cells; Leukocytes (neutrophilic); Larvae; Antibiotics; Infection; Parasite resistance; Lymph nodes; Inflammation; Flow cytometry; Immunoglobulin E; Transforming growth factor- beta; Immunoglobulin G; Lymphocytes T; Inoculation; Cytokines; Immune response; Tumor necrosis factor- alpha; Nippostrongylus brasiliensis; Nematoda ER - TY - JOUR T1 - Recent Developments in Synthetic Oligosaccharide-Based Bacterial Vaccines AN - 19991192; 7924335 AB - Synthetic advances made possible chemical assembly of complex oligosaccharide fragments of polysaccharide domains on the surface of human pathogenic bacteria. These oligosaccharides may be recognized by antibodies raised against high molecular weight, native, polysaccharides. In addition to their antigenicity, synthetic oligosaccharides can also function as haptens in their protein conjugates that can elicit not only oligo- but also polysaccharide-specific IgG antibodies in animal models and in humans. A major milestone in the development of new generation vaccines was the demonstration that protein conjugates of synthetic fragments of the capsular polysaccharide of Haemophilus influenzae type b are as efficacious in preventing childhood meningitis and other diseases as is the corresponding licensed commercial vaccine containing the bacterial polysaccharide. The lessons learnt in this and other endeavors described herein are manifold. For example, they teach us about the significance of the oligosaccharide epitope size, the number of their copies per protein in the conjugate, the possible effect of the spacer on anti-saccharide immune response, and the proper choice of the carrier protein combined with the selection of the animal model. The H. influenzae b story also teaches us that that the synthetic approach can be commercially viable. JF - Current Topics in Medicinal Chemistry AU - Pozsgay, Vince AD - National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Dr., MSC 2423, Bethesda, MD 20892-2423, USA. Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 126 EP - 140 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 8 IS - 2 SN - 1568-0266, 1568-0266 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Haemophilus influenzae KW - oligosaccharides KW - Shigella Dysenteriae Type 1 KW - Streptococcus Pneumoniae KW - keyhole limpet hemocyanin KW - Bacteria KW - Antigenicity KW - Haptens KW - Animal models KW - Spacer KW - Children KW - Meningitis KW - Reviews KW - Immunoglobulin G KW - Immune response KW - Vaccines KW - Capsular polysaccharides KW - Epitopes KW - F 06905:Vaccines KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19991192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.atitle=Recent+Developments+in+Synthetic+Oligosaccharide-Based+Bacterial+Vaccines&rft.au=Pozsgay%2C+Vince&rft.aulast=Pozsgay&rft.aufirst=Vince&rft.date=2008-01-01&rft.volume=8&rft.issue=2&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802608783378864 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - oligosaccharides; Antigenicity; Haptens; Animal models; Spacer; Children; Meningitis; Reviews; Immunoglobulin G; Vaccines; Immune response; Capsular polysaccharides; Epitopes; Bacteria; Haemophilus influenzae DO - http://dx.doi.org/10.2174/156802608783378864 ER - TY - JOUR T1 - Madurahydroxylactone Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and RNase H AN - 19984087; 7932108 AB - A series of 29 madurahydroxylactone derivatives was evaluated for dual inhibition of human immunodeficiency virus type 1 (HIV-1) integrase and RNase H. While most of the compounds exhibited similar potencies for both enzymes, two of the derivatives showed 10- to 100-fold-higher selectivity for each enzyme, suggesting that distinct pharmacophore models could be generated. This study exemplifies the common and divergent structural requirements for the inhibition of two structurally related HIV-1 enzymes and demonstrates the importance of systematically screening for both integrase and RNase H when developing novel inhibitors. JF - Antimicrobial Agents & Chemotherapy AU - Marchand, Christophe AU - Beutler, John A AU - Wamiru, Antony AU - Budihas, Scott AU - Moellmann, Ute AU - Heinisch, Lothar AU - Mellors, John W AU - Le Grice, Stuart F AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland. SAIC-Frederick, Frederick, Maryland. HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland. Department of Molecular and Applied Microbiology. Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany. Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 361 EP - 364 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Human immunodeficiency virus 1 KW - Ribonuclease H KW - Enzymes KW - pharmacophores KW - Integrase KW - Models KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19984087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Madurahydroxylactone+Derivatives+as+Dual+Inhibitors+of+Human+Immunodeficiency+Virus+Type+1+Integrase+and+RNase+H&rft.au=Marchand%2C+Christophe%3BBeutler%2C+John+A%3BWamiru%2C+Antony%3BBudihas%2C+Scott%3BMoellmann%2C+Ute%3BHeinisch%2C+Lothar%3BMellors%2C+John+W%3BLe+Grice%2C+Stuart+F%3BPommier%2C+Yves&rft.aulast=Marchand&rft.aufirst=Christophe&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ribonuclease H; Enzymes; pharmacophores; Models; Integrase; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Neutrophil Microbicides Induce a Pathogen Survival Response in Community-Associated Methicillin-Resistant Staphylococcus aureus AN - 19963105; 7935880 AB - In recent years, there has been a dramatic increase in the incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections. MW2 (pulsed-field type USA400), the prototype CA-MRSA strain, is highly virulent and has enhanced ability to evade killing by neutrophils. Although progress has been made, the molecular basis for enhanced virulence of CA-MRSA remains incompletely defined. To that end, we studied resistance of MW2 to key microbicides of human neutrophils. Hydrogen peroxide (H sub(2)O sub(2)), hypochlorous acid, and azurophilic granule proteins had significant bacteriostatic but limited staphylocidal activity toward MW2 under the conditions tested. An MW2-specific microarray revealed common changes in S. aureus gene expression following exposure to each microbicide, such as up-regulation of transcripts involved in gene regulation (e.g., saeRS and kdpDE) and stress response. Azurophilic granule proteins elicited the greatest number of changes in MW2 transcripts, including up-regulation of mRNAs encoding multiple toxins and hemolysins (e.g., hlgA, hlgB, hlgC, hla, lukS-PV, lukF-PV, sec4, and set17-26). Notably, H sub(2)O sub(2) triggered up-regulation of transcripts related to heme/iron uptake (e.g., isdA, isdB, and isdCDEFsrtBisdG), and an isogenic isdAB-negative strain of MW2 had increased susceptibility to H sub(2)O sub(2) (p < 0.001) and human neutrophils (p < 0.05) compared with the wild-type parental strain. These findings reveal a S. aureus survival response wherein Iron-regulated surface determinant (Isd) proteins are important for resistance to innate host defense. Collectively, the data provide an enhanced view of the mechanisms used by S. aureus to circumvent destruction by the innate immune system. JF - Journal of Immunology AU - Palazzolo-Ballance, Amy M AU - Reniere, Michelle L AU - Braughton, Kevin R AU - Sturdevant, Daniel E AU - Otto, Michael AU - Kreiswirth, Barry N AU - Skaar, Eric P AU - DeLeo, Frank R AD - Laboratory of Human Bacterial Pathogenesis and Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840. Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232. Public Health Research Institute Tuberculosis Center, International Center for Public Health, Newark, NJ 07103 Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 500 EP - 509 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 1 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Histocompatibility antigen HLA KW - Cell survival KW - Granules KW - Data processing KW - Heme KW - Drug resistance KW - Immune system KW - Hypochlorous acid KW - Leukocytes (neutrophilic) KW - Stress KW - Pathogens KW - Infection KW - DNA microarrays KW - Toxins KW - Virulence KW - Hydrogen peroxide KW - Gene regulation KW - Staphylococcus aureus KW - Iron KW - Hemolysins KW - microbicides KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19963105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Neutrophil+Microbicides+Induce+a+Pathogen+Survival+Response+in+Community-Associated+Methicillin-Resistant+Staphylococcus+aureus&rft.au=Palazzolo-Ballance%2C+Amy+M%3BReniere%2C+Michelle+L%3BBraughton%2C+Kevin+R%3BSturdevant%2C+Daniel+E%3BOtto%2C+Michael%3BKreiswirth%2C+Barry+N%3BSkaar%2C+Eric+P%3BDeLeo%2C+Frank+R&rft.aulast=Palazzolo-Ballance&rft.aufirst=Amy&rft.date=2008-01-01&rft.volume=180&rft.issue=1&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Granules; Cell survival; Histocompatibility antigen HLA; Data processing; Heme; Immune system; Drug resistance; Hypochlorous acid; Leukocytes (neutrophilic); Stress; Pathogens; Infection; DNA microarrays; Toxins; Virulence; Hydrogen peroxide; Gene regulation; Hemolysins; Iron; microbicides; Staphylococcus aureus ER - TY - JOUR T1 - Comparative In Vitro Pharmacodynamics of Caspofungin, Micafungin, and Anidulafungin against Germinated and Nongerminated Aspergillus Conidia AN - 19961764; 7932098 AB - The concentration-dependent effects of echinocandins on the metabolic activity of Aspergillus spp. were comparatively studied by using nongerminated and germinated conidia. The susceptibilities of 11 Aspergillus fumigatus, 8 A. terreus and 8 A. flavus isolates to caspofungin, micafungin, and anidulafungin were studied by a CLSI (formerly NCCLS) M38-A broth microdilution-based method. After 48 h of incubation the minimum effective concentration (MEC) was defined microscopically. Metabolic activity was assessed by the 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxa n ilide assay and modeled by using the sigmoid (E sub(max)) or "bell-shaped" model. The median MEC values of caspofungin (0.5 to 1 mu g/ml), micafungin (0.06 to 0.12 mu g/ml), and anidulafungin (0.03 mu g/ml) against nongerminated conidia increased by 0 to 1, 1 to 2, and 2 to 3 twofold dilutions, respectively (depending on the species), over those against germinated conidia. A similar shift to the right was demonstrated for the corresponding curves of metabolic activity. There was a significant correlation between the degrees of maximal metabolic inhibition caused by different echinocandins at both the species level (greater inhibition for A. flavus) and the strain level (r = 0.84 to 0.93; P < 0.0001). Paradoxical increases in metabolism in the presence of higher concentrations of caspofungin, micafungin, and anidulafungin were detected in 6, 2, and 5 of the A. fumigatus isolates, respectively; 5, 1, and 2 of the A. terreus isolates, respectively; and 1, 0, and 0 of the A. flavus isolates, respectively. Based on the model, 50% of the maximal paradoxical increase was detected with 4.2, 11.1, and 10.8 mu g/ml of caspofungin, micafungin, and anidulafungin, respectively. All echinocandins therefore exerted comparable levels of maximal metabolic inhibition against Aspergillus spp. at concentrations that were differentially increased for germinated versus nongerminated conidia. The paradoxical increase in metabolism occurred more frequently and at lower concentrations with caspofungin than with micafungin and anidulafungin. JF - Antimicrobial Agents & Chemotherapy AU - Antachopoulos, Charalampos AU - Meletiadis, Joseph AU - Sein, Tin AU - Roilides, Emmanuel AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland. Third Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 321 EP - 328 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 52 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Aspergillus flavus KW - Aspergillus fumigatus KW - micafungin KW - Caspofungin KW - Conidia KW - echinocandins KW - Metabolism KW - Pharmacodynamics KW - Models KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19961764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Comparative+In+Vitro+Pharmacodynamics+of+Caspofungin%2C+Micafungin%2C+and+Anidulafungin+against+Germinated+and+Nongerminated+Aspergillus+Conidia&rft.au=Antachopoulos%2C+Charalampos%3BMeletiadis%2C+Joseph%3BSein%2C+Tin%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Antachopoulos&rft.aufirst=Charalampos&rft.date=2008-01-01&rft.volume=52&rft.issue=1&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - micafungin; Caspofungin; Conidia; echinocandins; Pharmacodynamics; Metabolism; Models; Aspergillus flavus; Aspergillus fumigatus ER - TY - JOUR T1 - (p)ppGpp: Still Magical? AN - 19899775; 8689282 AB - The fundamental details of how nutritional stress leads to elevating (p)ppGpp are questionable. By common usage, the meaning of the stringent response has evolved from the specific response to (p)ppGpp provoked by amino acid starvation to all responses caused by elevating (p)ppGpp by any means. Different responses have similar as well as dissimilar positive and negative effects on gene expression and metabolism. The different ways that different bacteria seem to exploit their capacities to form and respond to (p)ppGpp are already impressive despite an early stage of discovery. Apparently, (p)ppGpp can contribute to regulation of many aspects of microbial cell biology that are sensitive to changing nutrient availability: growth, adaptation, secondary metabolism, survival, persistence, cell division, motility, biofilms, development, competence, and virulence. Many basic questions still exist. This review tries to focus on some issues that linger even for the most widely characterized bacterial strains. JF - Annual Review of Microbiology AU - Potrykus, Katarzyna AU - Cashel, Michael AD - Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892- 2785, potrykuk@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 35 EP - 51 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 62 SN - 0066-4227, 0066-4227 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Stringent response KW - Cell survival KW - Adaptations KW - Nutrient availability KW - Gene expression KW - Virulence KW - Motility KW - Cell division KW - Nutrient deficiency KW - Reviews KW - Amino acid starvation KW - Cell migration KW - Biofilms KW - Metabolism KW - A 01310:Products of Microorganisms KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19899775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Microbiology&rft.atitle=%28p%29ppGpp%3A+Still+Magical%3F&rft.au=Potrykus%2C+Katarzyna%3BCashel%2C+Michael&rft.aulast=Potrykus&rft.aufirst=Katarzyna&rft.date=2008-01-01&rft.volume=62&rft.issue=&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Microbiology&rft.issn=00664227&rft_id=info:doi/10.1146%2Fannurev.micro.62.081307.162903 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Stringent response; Adaptations; Nutrient availability; Virulence; Gene expression; Nutrient deficiency; Cell division; Motility; Reviews; Amino acid starvation; Biofilms; Cell migration; Metabolism DO - http://dx.doi.org/10.1146/annurev.micro.62.081307.162903 ER - TY - JOUR T1 - Physico-chemical modifications of conjugated linoleic acid for ruminal protection and oxidative stability AN - 19896185; 8522931 AB - Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of octadecadienoic acid [linoleic acid (LA), 18:2n-6]. Although ruminant milk and meat products represent the largest natural source of CLA and therefore, their concentration in ruminant lipids are of interest to human health, chemical or physical modifications of CLA should be needed as a means to enhance oxidative stability, to improve post-ruminal bioavailability, and to increase the clinical application. In fact, CLA are rapidly decomposed to form furan fatty acids when its are oxidized in air, and the effectiveness of dietary supplements of CLA may be related to the extent that their metabolisms by rumen bacteria are avoided. For these reasons, many scientists have examined the effect of manufacturing and protection on the stability of CLA in ruminants and food products. In this review, physico-chemical modifications of CLA for ruminal protection such as calcium salt (Ca), formaldehyde protection (FP), lipid encapsulation (LE), and amide linkage (AL), and for oxidative stability such as green tea catechin (GTC), cyclodextrin (CD), arginine (Arg), amylase, and PEGylation are proposed. JF - Nutrition & Metabolism AU - Moon, Hyun-Seuk AU - Lee, Hong-Gu AU - Chung, Chung-Soo AU - Choi, Yun-Jaie AU - Cho, Chong-Su AD - Laboratory of Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9410, USA, moonh2@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 16 PB - BioMed Central Ltd., Middlesex House VL - 5 SN - 1743-7075, 1743-7075 KW - Microbiology Abstracts B: Bacteriology KW - Meat products KW - Ruminantia KW - Calcium KW - Lipids KW - Food KW - Therapeutic applications KW - Formaldehyde KW - Catechin KW - Isomers KW - Encapsulation KW - Bioavailability KW - Linoleic acid KW - Milk KW - Rumen KW - green tea KW - Arginine KW - Furans KW - Salts KW - cyclodextrin KW - Reviews KW - Dietary supplements KW - Fatty acids KW - amides KW - Metabolism KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19896185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+%26+Metabolism&rft.atitle=Physico-chemical+modifications+of+conjugated+linoleic+acid+for+ruminal+protection+and+oxidative+stability&rft.au=Moon%2C+Hyun-Seuk%3BLee%2C+Hong-Gu%3BChung%2C+Chung-Soo%3BChoi%2C+Yun-Jaie%3BCho%2C+Chong-Su&rft.aulast=Moon&rft.aufirst=Hyun-Seuk&rft.date=2008-01-01&rft.volume=5&rft.issue=&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Nutrition+%26+Metabolism&rft.issn=17437075&rft_id=info:doi/10.1186%2F1743-7075-5-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Meat products; Calcium; Milk; Rumen; Arginine; green tea; Food; Lipids; Formaldehyde; Therapeutic applications; Catechin; Furans; Encapsulation; Isomers; Bioavailability; Salts; cyclodextrin; Dietary supplements; Reviews; Fatty acids; amides; Metabolism; Linoleic acid; Ruminantia DO - http://dx.doi.org/10.1186/1743-7075-5-16 ER - TY - JOUR T1 - The Influenza Virus Resource at the National Center for Biotechnology Information AN - 19895039; 7936486 JF - Journal of Virology AU - Bao, Yiming AU - Bolotov, Pavel AU - Dernovoy, Dmitry AU - Kiryutin, Boris AU - Zaslavsky, Leonid AU - Tatusova, Tatiana AU - Ostell, Jim AU - Lipman, David AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 596 EP - 601 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 82 IS - 2 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts KW - Influenza KW - Influenza virus KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19895039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+Influenza+Virus+Resource+at+the+National+Center+for+Biotechnology+Information&rft.au=Bao%2C+Yiming%3BBolotov%2C+Pavel%3BDernovoy%2C+Dmitry%3BKiryutin%2C+Boris%3BZaslavsky%2C+Leonid%3BTatusova%2C+Tatiana%3BOstell%2C+Jim%3BLipman%2C+David&rft.aulast=Bao&rft.aufirst=Yiming&rft.date=2008-01-01&rft.volume=82&rft.issue=2&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Influenza; Influenza virus ER - TY - JOUR T1 - Epidemic community-associated methicillin-resistant Staphylococcus aureus: Recent clonal expansion and diversification AN - 19892113; 8042202 AB - Emerging and re-emerging infectious diseases, especially those caused by drug-resistant bacteria, are a major problem worldwide. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) appeared rapidly and unexpectedly in the United States, resulting in an epidemic caused primarily by isolates classified as USA300. The evolutionary and molecular underpinnings of this epidemic are poorly understood. Specifically, it is unclear whether there has been clonal emergence of USA300 isolates or evolutionary convergence toward a hypervirulent phenotype resulting in the independent appearance of similar organisms. To definitively resolve this issue and understand the phylogeny of USA300 isolates, we used comparative whole-genome sequencing to analyze 10 USA300 patient isolates from eight states in diverse geographic regions of the United States and multiple types of human infection. Eight of 10 isolates analyzed had very few single nucleotide polymorphisms (SNPs) and thus were closely related, indicating recent diversification rather than convergence. Unexpectedly, 2 of the clonal isolates had significantly reduced mortality in a mouse sepsis model compared with the reference isolate (P = 0.0002), providing strong support to the idea that minimal genetic change in the bacterial genome can have profound effects on virulence. Taken together, our results demonstrate that there has been recent clonal expansion and diversification of a subset of isolates classified as USA300. The findings add an evolutionary dimension to the epidemiology and emergence of USA300 and suggest a similar mechanism for the pandemic occurrence and spread of penicillin-resistant S. aureus (known as phage-type 80/81 S. aureus) in the 1950s. JF - Proceedings of the National Academy of Sciences, USA AU - Kennedy, Adam D AU - Otto, Michael AU - Braughton, Kevin R AU - Whitney, Adeline R AU - Chen, Liang AU - Mathema, Barun AU - Mediavilla, Jose R AU - Byrne, Kelly A AU - Parkins, Larye D AU - Tenover, Fred C AU - Kreiswirth, Barry N AU - Musser, James M AU - DeLeo, Frank R AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 1327 EP - 1332 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 105 IS - 4 SN - 0027-8424, 0027-8424 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Genomes KW - Mortality KW - Epidemics KW - Drug resistance KW - Animal models KW - Infection KW - Virulence KW - pandemics KW - Sepsis KW - Epidemiology KW - Infectious diseases KW - Single-nucleotide polymorphism KW - Convergence KW - Staphylococcus aureus KW - Evolution KW - N 14845:Miscellaneous KW - G 07770:Bacteria KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19892113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Epidemic+community-associated+methicillin-resistant+Staphylococcus+aureus%3A+Recent+clonal+expansion+and+diversification&rft.au=Kennedy%2C+Adam+D%3BOtto%2C+Michael%3BBraughton%2C+Kevin+R%3BWhitney%2C+Adeline+R%3BChen%2C+Liang%3BMathema%2C+Barun%3BMediavilla%2C+Jose+R%3BByrne%2C+Kelly+A%3BParkins%2C+Larye+D%3BTenover%2C+Fred+C%3BKreiswirth%2C+Barry+N%3BMusser%2C+James+M%3BDeLeo%2C+Frank+R&rft.aulast=Kennedy&rft.aufirst=Adam&rft.date=2008-01-01&rft.volume=105&rft.issue=4&rft.spage=1327&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Phylogeny; Mortality; Epidemics; Drug resistance; Animal models; Infection; Virulence; Sepsis; pandemics; Infectious diseases; Epidemiology; Convergence; Single-nucleotide polymorphism; Evolution; Staphylococcus aureus ER - TY - JOUR T1 - Ligand activation of peroxisome proliferator-activated receptor- beta / delta (PPAR beta / delta ) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms AN - 19887699; 8035838 AB - Cyclooxygenase (COX) 2-derived prostaglandin E sub(2) (PGE sub(2)) promotes colorectal carcinoma growth and invasion, and inhibition of COX2 by non-steroidal anti-inflammatory drugs is known to inhibit these processes. There is controversy regarding the effect of ligand activation of peroxisome proliferator-activated receptor (PPAR)- beta / delta on colon carcinogenesis, although collective evidence from independent laboratories suggest that ligand activation of PPAR beta / delta leads to the induction of terminal differentiation coupled with inhibition of cell growth in a variety of models. The present study examined the hypothesis that ligand activation of PPAR beta / delta and inhibition of COX2 attenuate colon cancer through independent mechanisms and that combining these two mechanisms will enhance this inhibition. Colon cancer was induced by administering azoxymethane to wild-type and PPAR beta / delta -null mice. Cohorts of mice were treated with GW0742 (a PPAR beta / delta ligand), nimesulide (a COX2 inhibitor) or a combination of GW0742 and nimesulide. Inhibition of COX2 by nimesulide attenuated colon cancer and ligand activation of PPAR beta / delta by GW0742 had inhibitory effects. However, the combined treatment of GW0742 and nimesulide did not cause an enhancement in the attenuation of colon cancer. Mechanistically, the effects of these compounds occurred through independent mechanisms as increased levels of differentiation markers as a result of ligand activation of PPAR beta / delta were not found with COX2 inhibition, and a reduction in PGE sub(2) levels resulting from COX2 inhibition was not observed in response to ligand activation of PPAR beta / delta . Results from these studies effectively dissociate COX2 inhibition and PPAR beta / delta activity during colon carcinogenesis. JF - Carcinogenesis AU - Hollingshead, Holly E AU - Borland, Michael G AU - Billin, Andrew N AU - Willson, Timothy M AU - Gonzalez, Frank J AU - Peters, Jeffrey M AD - Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis. Graduate Program in Biochemistry, Microbiology, and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA. Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. Laboratory of Metabolism, National Cancer Institute, Bethesda, MD 20892, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 169 EP - 176 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 29 IS - 1 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Cyclooxygenase-2 KW - Peroxisome proliferator-activated receptors KW - Animal models KW - Colon cancer KW - Prostaglandin E2 KW - nimesulide KW - Differentiation KW - Azoxymethane KW - Carcinogenesis KW - Colorectal carcinoma KW - Nonsteroidal antiinflammatory drugs KW - Signal transduction KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19887699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Ligand+activation+of+peroxisome+proliferator-activated+receptor-+beta+%2F+delta+%28PPAR+beta+%2F+delta+%29+and+inhibition+of+cyclooxygenase+2+%28COX2%29+attenuate+colon+carcinogenesis+through+independent+signaling+mechanisms&rft.au=Hollingshead%2C+Holly+E%3BBorland%2C+Michael+G%3BBillin%2C+Andrew+N%3BWillson%2C+Timothy+M%3BGonzalez%2C+Frank+J%3BPeters%2C+Jeffrey+M&rft.aulast=Hollingshead&rft.aufirst=Holly&rft.date=2008-01-01&rft.volume=29&rft.issue=1&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Differentiation; Peroxisome proliferator-activated receptors; Azoxymethane; Carcinogenesis; Animal models; Colorectal carcinoma; Prostaglandin E2; Colon cancer; Signal transduction; Nonsteroidal antiinflammatory drugs; nimesulide ER - TY - JOUR T1 - Neuropilin-2: A New Molecular Target for Antiangiogenic and Antitumor Strategies AN - 19883147; 8039947 JF - Journal of the National Cancer Institute AU - Narazaki, Masashi AU - Segarra, Marta AU - Tosato, Giovanna AD - Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, Bethesda, MD (MS, GT) Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 81 EP - 83 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 100 IS - 2 SN - 0027-8874, 0027-8874 KW - Biotechnology and Bioengineering Abstracts KW - antiangiogenic agents KW - neuropilin KW - Antitumor agents KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19883147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Neuropilin-2%3A+A+New+Molecular+Target+for+Antiangiogenic+and+Antitumor+Strategies&rft.au=Narazaki%2C+Masashi%3BSegarra%2C+Marta%3BTosato%2C+Giovanna&rft.aulast=Narazaki&rft.aufirst=Masashi&rft.date=2008-01-01&rft.volume=100&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - antiangiogenic agents; neuropilin; Antitumor agents ER - TY - JOUR T1 - Visualization of large influenza virus sequence datasets using adaptively aggregated trees with sampling-based subscale representation AN - 19868338; 8522286 AB - Background With the amount of influenza genome sequence data growing rapidly, researchers need machine assistance in selecting datasets and exploring the data. Enhanced visualization tools are required to represent results of the exploratory analysis on the web in an easy-to-comprehend form and to facilitate convenient information retrieval. Results We developed an approach to visualize large phylogenetic trees in an aggregated form with a special representation of subscale details. The initial aggregated tree representation is built with a level of resolution automatically selected to fit into the available screen space, with terminal groups selected based on sequence similarity. The default aggregated representation can be refined by users interactively. Structure and data variability within terminal groups are displayed using small trees that have the same vertical size as the text annotation of the group. These subscale representations are calculated using systematic sampling from the corresponding terminal group. The aggregated tree containing terminal groups can be annotated using aggregation of structured metadata, such as seasonal distribution, geographic locations, etc. Availability The algorithms are implemented in JavaScript within the NCBI Influenza Virus Resource [ 1 ]. JF - BMC Bioinformatics AU - Zaslavsky, Leonid AU - Bao, Yiming AU - Tatusova, Tatiana A AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, zaslavsk@ncbi.nlm.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 237 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Influenza KW - Genomes KW - Phylogeny KW - Influenza virus KW - Data processing KW - Information processing KW - Nucleotide sequence KW - Algorithms KW - Bioinformatics KW - Sampling KW - G 07880:Human Genetics KW - N 14810:Methods KW - V 22310:Genetics, Taxonomy & Structure KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19868338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Visualization+of+large+influenza+virus+sequence+datasets+using+adaptively+aggregated+trees+with+sampling-based+subscale+representation&rft.au=Zaslavsky%2C+Leonid%3BBao%2C+Yiming%3BTatusova%2C+Tatiana+A&rft.aulast=Zaslavsky&rft.aufirst=Leonid&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; Influenza; Data processing; Nucleotide sequence; Information processing; Algorithms; Sampling; Bioinformatics; Influenza virus DO - http://dx.doi.org/10.1186/1471-2105-9-237 ER - TY - JOUR T1 - The Periplasmic Domain of TolR from Haemophilus influenzae Forms a Dimer with a Large Hydrophobic Groove: NMR Solution Structure and Comparison to SAXS Data super([dagger]) super(,) super([dagger]) AN - 19812257; 8134068 AB - TolR is a part of the Pal/Tol system which forms a five-member, membrane- spanning, multiprotein complex that is conserved in Gram-negative bacteria. The Pal/Tol system helps to maintain the integrity of the outer membrane and has been proposed to be involved in several other cellular processes including cell division. Obtaining the structure of TolR is of interest not only to help explain the many proposed functions of the Pal/Tol system but also to gain an understanding of the TolR homologues ExbD and MotB and to provide more targets for antibacterial treatments. In addition, the structure may provide insights into how colicins and bacteriophages are able to enter the cell. Here we report the solution structure of the homodimeric periplasmic domain of TolR from Haemophilus influenzae, determined with conventional, NOE-based NMR spectroscopy, supplemented by extensive residual dipolar coupling measurements. A novel method for assembling the dimer from small-angle X-ray scattering data confirms the NMR-derived structure. To facilitate NMR spectral analysis, a TolR construct containing residues 59-130 of the 139-residue protein was created. The periplasmic domain of TolR forms a C sub(2)-symmetric dimer consisting of a strongly curved eight-stranded beta -sheet, generating a large deep groove on one side, while four helices cover the other face of the sheet. The structure of the TolR dimer together with data from the literature suggests how the periplasmic domain of TolR is most likely oriented relative to the cytoplasmic membrane and how it may interact with other components of the Pal/Tol system, particularly TolQ. JF - Biochemistry (Washington) AU - Bax, Ad AU - Parsons, Lisa M AU - Grishaev, Alexander AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 5 Memorial Drive, Bethesda, Maryland 20892 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 3131 EP - 3142 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 47 IS - 10 SN - 0006-2960, 0006-2960 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Phages KW - Haemophilus influenzae KW - Data processing KW - Outer membranes KW - Hydrophobicity KW - Cell division KW - Magnetic resonance spectroscopy KW - Gram-negative bacteria KW - X-ray scattering KW - Colicins KW - Cytoplasmic membranes KW - Proteins KW - N.M.R. KW - V 22300:Methods KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19812257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=The+Periplasmic+Domain+of+TolR+from+Haemophilus+influenzae+Forms+a+Dimer+with+a+Large+Hydrophobic+Groove%3A+NMR+Solution+Structure+and+Comparison+to+SAXS+Data+super%28%5Bdagger%5D%29+super%28%2C%29+super%28%5Bdagger%5D%29&rft.au=Bax%2C+Ad%3BParsons%2C+Lisa+M%3BGrishaev%2C+Alexander&rft.aulast=Bax&rft.aufirst=Ad&rft.date=2008-01-01&rft.volume=47&rft.issue=10&rft.spage=3131&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi702283x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Phages; Cell division; Data processing; Gram-negative bacteria; Magnetic resonance spectroscopy; Outer membranes; Cytoplasmic membranes; Colicins; X-ray scattering; Proteins; Hydrophobicity; N.M.R.; Haemophilus influenzae DO - http://dx.doi.org/10.1021/bi702283x ER - TY - JOUR T1 - Early Depletion of Mycobacterium tuberculosis-Specific T Helper 1 Cell Responses after HIV-1 Infection AN - 19807470; 8637895 AB - Background. The acid-fast bacillus Mycobacterium tuberculosis is often the first manifestation of acquired immunodeficiency syndrome in patients infected with human immunodeficiency virus (HIV). This study was conducted to better understand the mechanism underlying M. tuberculosis- specific pathogenicity early after onset of HIV infection. Methods. M. tuberculosis-specific T helper 1 (Th1) cells were studied in HIV negative and chronically HIV infected Tanzanian subjects by using early secreted antigenic target 6 (ESAT6) protein or tuberculin (purified protein derivative) with interferon- ELISPOT and intracellular cytokine staining. In a longitudinal study, the effect of acute HIV infection on M. tuberculosis-specific Th1 cells was determined by polychromatic flow cytometric analysis in 5 subjects with latent M. tuberculosis infection who became infected with HIV. Results. In tuberculosis (TB)-asymptomatic subjects (i.e., subjects with unknown TB status who did not show clinical signs suggestive of TB), chronic HIV infection was associated with a decreased percentage of subjects with detectable M. tuberculosis-specific Th1 cells, a decrease which was not observed among subjects with active TB. Acute HIV infection induced a rapid depletion of M. tuberculosis-specific Th1 cells in 4 subjects remained TB asymptomatic, whereas the population of these cells remained stable in subjects who remained HIV negative. Conclusions. Taken together, these data suggest a mechanism of rapid M. tuberculosis-specific Th1 cell depletion that may contribute to the early onset of TB in individuals with latent M. tuberculosis infection who become HIV infected. JF - Journal of Infectious Diseases AU - Geldmacher, Christof AU - Schuetz, Alexandra AU - Ngwenyama, Njabulo AU - Casazza, Joseph P AU - Sanga, Erica AU - Saathoff, Elmar AU - Boehme, Catharina AU - Geis, Steffen AU - Maboko, Leonard AU - Singh, Mahavir AU - Minja, Fred AU - Meyerhans, Andreas AU - Koup, Richard A AU - Hoelscher, Michael AD - Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, geldmacher@lrz.uni-muenchen.de Y1 - 2008 PY - 2008 DA - 2008 SP - 1590 EP - 1598 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 198 IS - 11 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - Data processing KW - Helper cells KW - Immunodeficiency KW - Flow cytometry KW - Interferon KW - Pathogenicity KW - Human immunodeficiency virus 1 KW - Chronic infection KW - Lymphocytes T KW - Cytokines KW - Tuberculin KW - Tuberculosis KW - Bacillus KW - ESAT-6 antigen KW - Mycobacterium tuberculosis KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19807470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Early+Depletion+of+Mycobacterium+tuberculosis-Specific+T+Helper+1+Cell+Responses+after+HIV-1+Infection&rft.au=Geldmacher%2C+Christof%3BSchuetz%2C+Alexandra%3BNgwenyama%2C+Njabulo%3BCasazza%2C+Joseph+P%3BSanga%2C+Erica%3BSaathoff%2C+Elmar%3BBoehme%2C+Catharina%3BGeis%2C+Steffen%3BMaboko%2C+Leonard%3BSingh%2C+Mahavir%3BMinja%2C+Fred%3BMeyerhans%2C+Andreas%3BKoup%2C+Richard+A%3BHoelscher%2C+Michael&rft.aulast=Geldmacher&rft.aufirst=Christof&rft.date=2008-01-01&rft.volume=198&rft.issue=11&rft.spage=1590&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F593017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Data processing; Helper cells; Immunodeficiency; Flow cytometry; Interferon; Pathogenicity; Chronic infection; Lymphocytes T; Cytokines; Tuberculosis; Tuberculin; ESAT-6 antigen; Human immunodeficiency virus 1; Bacillus; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1086/593017 ER - TY - JOUR T1 - Gene Set Expression Comparison kit for BRB-ArrayTools AN - 19801290; 7933017 AB - SUMMARY: A Gene Set Expression Comparison kit is developed as a module of BRB-ArrayTools for discovering biologically meaningful patterns in gene expression data. The kit consists of gene sets of transcription factor (TF) targets, gene sets containing genes whose protein products share the same protein domain and gene sets of microRNA targets. Using this module of BRB-ArrayTools, researchers can efficiently analyze pre-defined sets of gene whose expression is correlated with a categorical quantitative phenotype or patient survival. AVAILABILITY: Gene Set Expression Comparison kit is freely available as a module of BRB-ArrayTools for non-commercial users. BRB-ArrayTools is available at http://linus.nci.nih.gov/BRB-ArrayTools.html. Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Xu, Xiaojiang AU - Zhao, Yingdong AU - Simon, Richard AD - Biometric Research Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-7434, USA, rsimon@mail.nih.gov Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 137 EP - 139 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 24 IS - 1 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - Transcription factors KW - miRNA KW - Survival KW - Bioinformatics KW - double prime A gene KW - G 07880:Human Genetics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19801290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Gene+Set+Expression+Comparison+kit+for+BRB-ArrayTools&rft.au=Xu%2C+Xiaojiang%3BZhao%2C+Yingdong%3BSimon%2C+Richard&rft.aulast=Xu&rft.aufirst=Xiaojiang&rft.date=2008-01-01&rft.volume=24&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Transcription factors; miRNA; Survival; Bioinformatics; double prime A gene ER - TY - JOUR T1 - UPLC-ESI-TOFMS-Based Metabolomics and Gene Expression Dynamics Inspector Self-Organizing Metabolomic Maps as Tools for Understanding the Cellular Response to Ionizing Radiation AN - 19794259; 8019764 AB - Global transcriptomic and proteomic profiling platforms have yielded important insights into the complex response to ionizing radiation (IR). Nonetheless, little is known about the ways in which small cellular metabolite concentrations change in response to IR. Here, a metabolomics approach using ultraperformance liquid chromatography coupled with electrospray time-of-flight mass spectrometry was used to profile, over time, the hydrophilic metabolome of TK6 cells exposed to IR doses ranging from 0.5 to 8.0 Gy. Multivariate data analysis of the positive ions revealed dose- and time-dependent clustering of the irradiated cells and identified certain constituents of the water-soluble metabolome as being significantly depleted as early as 1 h after IR. Tandem mass spectrometry was used to confirm metabolite identity. Many of the depleted metabolites are associated with oxidative stress and DNA repair pathways. Included are reduced glutathione, adenosine monophosphate, nicotinamide adenine dinucleotide, and spermine. Similar measurements were performed with a transformed fibroblast cell line, BJ, and it was found that a subset of the identified TK6 metabolites were effective in IR dose discrimination. The GEDI (Gene Expression Dynamics Inspector) algorithm, which is based on self-organizing maps, was used to visualize dynamic global changes in the TK6 metabolome that resulted from IR. It revealed dose-dependent clustering of ions sharing the same trends in concentration change across radiation doses. "Radiation metabolomics," the application of metabolomic analysis to the field of radiobiology, promises to increase our understanding of cellular responses to stressors such as radiation. JF - Analytical Chemistry (Washington) AU - Patterson, Andrew D AU - Li, Henghong AU - Eichler, Gabriel S AU - Krausz, Kristopher W AU - Weinstein, John N AU - Fornace, Albert J AU - Gonzalez, Frank J AU - Idlepara.Gif, Jeffrey R AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, Lombardi Comprehensive Cancer Research Center, Georgetown University, Washington, District of Columbia, Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2008 PY - 2008 DA - 2008 SP - 665 EP - 674 PB - American Chemical Society, Box 3337 Columbus OH 43210 USA, [mailto:service@acs.org] VL - 80 IS - 3 SN - 0003-2700, 0003-2700 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Ions KW - Spermine KW - Data processing KW - Glutathione KW - Algorithms KW - Metabolites KW - AMP KW - DNA repair KW - Mass spectroscopy KW - Fibroblasts KW - Gene expression KW - NAD KW - Oxidative stress KW - Liquid chromatography KW - Ionizing radiation KW - proteomics KW - metabolomics KW - Gene mapping KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=UPLC-ESI-TOFMS-Based+Metabolomics+and+Gene+Expression+Dynamics+Inspector+Self-Organizing+Metabolomic+Maps+as+Tools+for+Understanding+the+Cellular+Response+to+Ionizing+Radiation&rft.au=Patterson%2C+Andrew+D%3BLi%2C+Henghong%3BEichler%2C+Gabriel+S%3BKrausz%2C+Kristopher+W%3BWeinstein%2C+John+N%3BFornace%2C+Albert+J%3BGonzalez%2C+Frank+J%3BIdlepara.Gif%2C+Jeffrey+R&rft.aulast=Patterson&rft.aufirst=Andrew&rft.date=2008-01-01&rft.volume=80&rft.issue=3&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac701807vPII%3AS0003-2700%2870%2901807-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ions; Spermine; Data processing; Glutathione; Algorithms; AMP; Metabolites; DNA repair; Mass spectroscopy; Fibroblasts; Gene expression; NAD; Liquid chromatography; Oxidative stress; Ionizing radiation; proteomics; metabolomics; Gene mapping DO - http://dx.doi.org/10.1021/ac701807vPII:S0003-2700(70)01807-3 ER - TY - JOUR T1 - Carbon nanotubes based optical immunodetection of Staphylococcal Enterotoxin B (SEB) in food AN - 19757249; 8581042 AB - Staphylococcal enterotoxins (SEs) are a major cause of food-borne diseases, traditionally SEs assayed immunologically with ELISA. Carbon nanotubes' (CNT) unique mechanical and electronic properties combined with a large specific surface area make them attractive for biosensing. To investigate whether CNT could improve the sensitivity of ELISA assays, we developed an optical CNT immunosensor for the detection of Staphylococcal Enterotoxin B (SEB) in food. Anti-SEB antibodies were immobilized onto a CNT surface through electrostatic adsorption and then the antibody-nanotube mixture was bound onto a polycarbonate film. SEB was then detected by a "sandwich-type" ELISA assay on the polycarbonate film. The use of CNT increased the sensitivity of the immunosensor by at least 6-fold, lowering the detection limit of SEB. The CNT immunosensor was also able to detect SEB various foods, suggesting the utility of CNT for this and other optical-based immunological detection methods. JF - International Journal of Food Microbiology AU - Yang, Minghui AU - Kostov, Yordan AU - Rasooly, Avraham AD - Center for Advanced Sensor Technology, University of Maryland Baltimore County, Baltimore MD, 21250, United States, rasoolya@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 78 EP - 83 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 127 IS - 1-2 SN - 0168-1605, 0168-1605 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Staphylococcal enterotoxins KW - ELISA KW - Carbon nanotubes KW - Food safety KW - Enzyme-linked immunosorbent assay KW - Surface area KW - Food contamination KW - Staphylococcal enterotoxin B KW - Toxins KW - Food-borne diseases KW - Antibodies KW - immunosensors KW - Carbon KW - Adsorption KW - nanotubes KW - polycarbonate KW - nanotechnology KW - surface area KW - J 02330:Biochemistry KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19757249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Carbon+nanotubes+based+optical+immunodetection+of+Staphylococcal+Enterotoxin+B+%28SEB%29+in+food&rft.au=Yang%2C+Minghui%3BKostov%2C+Yordan%3BRasooly%2C+Avraham&rft.aulast=Yang&rft.aufirst=Minghui&rft.date=2008-01-01&rft.volume=127&rft.issue=1-2&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2008.06.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antibodies; Enzyme-linked immunosorbent assay; Carbon; immunosensors; Surface area; Adsorption; nanotubes; Staphylococcal enterotoxin B; Food-borne diseases; polycarbonate; Food contamination; Toxins; surface area; nanotechnology DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2008.06.012 ER - TY - JOUR T1 - Panton-Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community-Associated Methicillin-Resistant Staphylococcus aureus Disease AN - 19751662; 8585579 AB - Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice. JF - Journal of Infectious Diseases AU - Wardenburg, Juliane Bubeck AU - Palazzolo-Ballance, Amy M AU - Otto, Michael AU - Schneewind, Olaf AU - DeLeo, Frank R AD - Departments of Microbiology and Pediatrics, University of Chicago, Chicago, Illinois, fdeleo@niaid.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1166 EP - 1170 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 198 IS - 8 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Data processing KW - Skin KW - Epidemics KW - leukocidin KW - Drug resistance KW - Cytotoxins KW - Animal models KW - Infection KW - Virulence KW - Staphylococcus aureus KW - Pneumonia KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19751662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Panton-Valentine+Leukocidin+Is+Not+a+Virulence+Determinant+in+Murine+Models+of+Community-Associated+Methicillin-Resistant+Staphylococcus+aureus+Disease&rft.au=Wardenburg%2C+Juliane+Bubeck%3BPalazzolo-Ballance%2C+Amy+M%3BOtto%2C+Michael%3BSchneewind%2C+Olaf%3BDeLeo%2C+Frank+R&rft.aulast=Wardenburg&rft.aufirst=Juliane&rft.date=2008-01-01&rft.volume=198&rft.issue=8&rft.spage=1166&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F592053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Virulence; Epidemics; Skin; Data processing; leukocidin; Cytotoxins; Drug resistance; Animal models; Infection; Pneumonia; Staphylococcus aureus DO - http://dx.doi.org/10.1086/592053 ER - TY - JOUR T1 - Comparative analyses of bidirectional promoters in vertebrates AN - 19750714; 8522301 AB - Background Orthologous genes with deep phylogenetic histories are likely to retain similar regulatory features. In this report we utilize orthology assignments for pairs of genes co-regulated by bidirectional promoters to map the ancestral history of the promoter regions. Results Our mapping of bidirectional promoters from humans to fish shows that many such promoters emerged after the divergence of chickens and fish. Furthermore, annotations of promoters in deep phylogenies enable detection of missing data or assembly problems present in higher vertebrates. The functional importance of bidirectional promoters is indicated by selective pressure to maintain the arrangement of genes regulated by the promoter over long evolutionary time spans. Characteristics unique to bidirectional promoters are further elucidated using a technique for unsupervised classification, known as ESPERR. Conclusion Results of these analyses will aid in our understanding of the evolution of bidirectional promoters, including whether the regulation of two genes evolved as a consequence of their proximity or if function dictated their co-regulation. JF - BMC Bioinformatics AU - Yang, Mary Qu AU - Taylor, James AU - Elnitski, Laura AD - Genome Technology Branch, NHGRI, NIH, MD, USA, yangma@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - S9 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - Suppl 6 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Promoters KW - Data processing KW - Gene regulation KW - Transcription KW - Evolutionary genetics KW - Bioinformatics KW - orthology KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19750714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Comparative+analyses+of+bidirectional+promoters+in+vertebrates&rft.au=Yang%2C+Mary+Qu%3BTaylor%2C+James%3BElnitski%2C+Laura&rft.aulast=Yang&rft.aufirst=Mary&rft.date=2008-01-01&rft.volume=9&rft.issue=Suppl+6&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-S6-S9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; Promoters; Data processing; Gene regulation; Transcription; Bioinformatics; Evolutionary genetics; orthology DO - http://dx.doi.org/10.1186/1471-2105-9-S6-S9 ER - TY - JOUR T1 - The change in weight perception of weight status among the overweight: comparison of NHANES III (1988-1994) and 1999-2004 NHANES AN - 19725741; 9042745 AB - Objectives This study seeks to determine whether perception of weight status among the overweight has changed with the increasing overweight/obesity prevalence. Methods The perception of weight status was compared between overweight participants (BMI between 25.0-29.9 kg/m super(2)) from NHANES III (1988-1994) and overweight participants from NHANES 1999-2004. Perception of weight status was assessed by asking participants to classify their weight as about the right weight, underweight or overweight. Comparisons were made across age groups, genders, race/ethnicities and various income levels. Results Fewer overweight people during the NHANES 1999-2004 survey perceived themselves as overweight when compared to overweight people during the NHANES III survey. The change in distortion between the survey periods was greatest among persons with lower income, males and African-Americans. Conclusion The increase in overweight/obesity between the survey years (NHANES III and NHANES 1999-2004 has been accompanied with fewer overweight people perceiving themselves as overweight. JF - International Journal of Behavioral Nutrition and Physical Activity AU - Johnson-Taylor, Wendy L AU - Fisher, Rachel A AU - Hubbard, Van S AU - Starke-Reed, Pamela AU - Eggers, Paul S AD - US Department of Health and Human Services, National Institutes of Health, Division of Nutrition Research Coordination, Bethesda, MD, USA, wj50v@nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 9 PB - BioMed Central Ltd., Middlesex House VL - 5 SN - 1479-5868, 1479-5868 KW - Physical Education Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19725741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.atitle=The+change+in+weight+perception+of+weight+status+among+the+overweight%3A+comparison+of+NHANES+III+%281988-1994%29+and+1999-2004+NHANES&rft.au=Johnson-Taylor%2C+Wendy+L%3BFisher%2C+Rachel+A%3BHubbard%2C+Van+S%3BStarke-Reed%2C+Pamela%3BEggers%2C+Paul+S&rft.aulast=Johnson-Taylor&rft.aufirst=Wendy&rft.date=2008-01-01&rft.volume=5&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.issn=14795868&rft_id=info:doi/10.1186%2F1479-5868-5-9 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1479-5868-5-9 ER - TY - JOUR T1 - Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2 AN - 19718290; 8522796 AB - Background Cyclooxygenases (COX) -1 and -2 are key mediators of the inflammatory response in the central nervous system. Since COX-2 is inducible by inflammatory stimuli, it has been traditionally considered as the most appropriate target for anti-inflammatory drugs. However, the specific roles of COX-1 and COX-2 in modulating a neuroinflammatory response are unclear. Recently, we demonstrated that COX-1 deficient mice show decreased neuroinflammatory response and neuronal damage in response to lipopolysaccharide (LPS). Methods In this study, we investigated the role of COX-2 in the neuroinflammatory response to intracerebroventricular-injected LPS (5 mu g), a model of direct activation of innate immunity, using COX-2 deficient (COX-2 super(-/-)) and wild type (COX-2 super(+/+)) mice, as well as COX-2 super(+/+ )mice pretreated for 6 weeks with celecoxib, a COX-2 selective inhibitor. Results Twenty-four hours after LPS injection, COX-2 super(-/- )mice showed increased neuronal damage, glial cell activation, mRNA and protein expression of markers of inflammation and oxidative stress, such as cytokines, chemokines, iNOS and NADPH oxidase. Brain protein levels of IL-1 beta , NADPH oxidase subunit p67 super(phox), and phosphorylated-signal transducer and activator of transcription 3 (STAT3) were higher in COX-2 super(-/- )and in celecoxib-treated mice, compared to COX-2 super(+/+ )mice. The increased neuroinflammatory response in COX-2 super(-/- )mice was likely mediated by the upregulation of STAT3 and suppressor of cytokine signaling 3 (SOCS3). Conclusion These results show that inhibiting COX-2 activity can exacerbate the inflammatory response to LPS, possibly by increasing glial cells activation and upregulating the STAT3 and SOCS3 pathways in the brain. JF - Journal of Neuroinflammation AU - Aid, Saba AU - Langenbach, Robert AU - Bosetti, Francesca AD - Brain Physiology and Metabolism Section, National Institute on Aging, NIH, 9000 Memorial Drive, Bldg 9 Room 1S126, Bethesda, MD 20892, USA, aidsab@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 17 PB - BioMed Central Ltd., Middlesex House VL - 5 SN - 1742-2094, 1742-2094 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Cyclooxygenase-2 KW - Central nervous system KW - Chemokines KW - Celecoxib KW - Stat3 protein KW - Glial cells KW - Interleukin 1 KW - Brain KW - Animal models KW - SOCS-3 protein KW - Transcription KW - Immunity KW - Cell activation KW - Cyclooxygenase-1 KW - Inflammation KW - Nitric-oxide synthase KW - Gene expression KW - Oxidative stress KW - Lipopolysaccharides KW - NAD(P)H oxidase KW - Antiinflammatory agents KW - W 30940:Products KW - G 07730:Development & Cell Cycle KW - F 06910:Microorganisms & Parasites KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19718290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroinflammation&rft.atitle=Neuroinflammatory+response+to+lipopolysaccharide+is+exacerbated+in+mice+genetically+deficient+in+cyclooxygenase-2&rft.au=Aid%2C+Saba%3BLangenbach%2C+Robert%3BBosetti%2C+Francesca&rft.aulast=Aid&rft.aufirst=Saba&rft.date=2008-01-01&rft.volume=5&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroinflammation&rft.issn=17422094&rft_id=info:doi/10.1186%2F1742-2094-5-17 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Central nervous system; Chemokines; Celecoxib; Stat3 protein; Glial cells; Interleukin 1; Animal models; Brain; Transcription; SOCS-3 protein; Immunity; Inflammation; Cyclooxygenase-1; Cell activation; Gene expression; Nitric-oxide synthase; Oxidative stress; Lipopolysaccharides; NAD(P)H oxidase; Antiinflammatory agents DO - http://dx.doi.org/10.1186/1742-2094-5-17 ER - TY - JOUR T1 - Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data AN - 19716518; 8522386 AB - Background Target genes of a transcription factor (TF) Pou5f1 (Oct3/4 or Oct4), which is essential for pluripotency maintenance and self-renewal of embryonic stem (ES) cells, have previously been identified based on their response to Pou5f1 manipulation and occurrence of Chromatin-immunoprecipitation (ChIP)-binding sites in promoters. However, many responding genes with binding sites may not be direct targets because response may be mediated by other genes and ChIP-binding site may not be functional in terms of transcription regulation. Results To reduce the number of false positives, we propose to separate responding genes into groups according to direction, magnitude, and time of response, and to apply the false discovery rate (FDR) criterion to each group individually. Using this novel algorithm with stringent statistical criteria (FDR & 0.2) to a compendium of published and new microarray data (3, 6, 12, and 24 hr after Pou5f1 suppression) and published ChIP data, we identified 420 tentative target genes (TTGs) for Pou5f1. The majority of TTGs (372) were down-regulated after Pou5f1 suppression, indicating that the Pou5f1 functions as an activator of gene expression when it binds to promoters. Interestingly, many activated genes are potent suppressors of transcription, which include polycomb genes, zinc finger TFs, chromatin remodeling factors, and suppressors of signaling. Similar analysis showed that Sox2 and Nanog also function mostly as transcription activators in cooperation with Pou5f1. Conclusion We have identified the most reliable sets of direct target genes for key pluripotency genes - Pou5f1, Sox2, and Nanog, and found that they predominantly function as activators of downstream gene expression. Thus, most genes related to cell differentiation are suppressed indirectly. JF - BMC Genomics AU - Sharov, Alexei A AU - Masui, Shinji AU - Sharova, Lioudmila V AU - Piao, Yulan AU - Aiba, Kazuhiro AU - Matoba, Ryo AU - Xin, Li AU - Niwa, Hitoshi AU - Ko, Minoru SH AD - Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, Baltimore, MD 21224, USA, sharoval@mail.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 269 PB - BioMed Central Ltd., Middlesex House VL - 9 SN - 1471-2164, 1471-2164 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Statistics KW - Data processing KW - Chromatin remodeling KW - polycomb group proteins KW - Immunoprecipitation KW - Algorithms KW - Zinc finger proteins KW - DNA microarrays KW - Differentiation KW - Promoters KW - Transcription factors KW - Embryos KW - Oct-4 protein KW - Signal transduction KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Genomics&rft.atitle=Identification+of+Pou5f1%2C+Sox2%2C+and+Nanog+downstream+target+genes+with+statistical+confidence+by+applying+a+novel+algorithm+to+time+course+microarray+and+genome-wide+chromatin+immunoprecipitation+data&rft.au=Sharov%2C+Alexei+A%3BMasui%2C+Shinji%3BSharova%2C+Lioudmila+V%3BPiao%2C+Yulan%3BAiba%2C+Kazuhiro%3BMatoba%2C+Ryo%3BXin%2C+Li%3BNiwa%2C+Hitoshi%3BKo%2C+Minoru+SH&rft.aulast=Sharov&rft.aufirst=Alexei&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=BMC+Genomics&rft.issn=14712164&rft_id=info:doi/10.1186%2F1471-2164-9-269 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Statistics; polycomb group proteins; Chromatin remodeling; Algorithms; Immunoprecipitation; Zinc finger proteins; DNA microarrays; Promoters; Differentiation; Transcription factors; Embryos; Oct-4 protein; Signal transduction DO - http://dx.doi.org/10.1186/1471-2164-9-269 ER - TY - JOUR T1 - GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression AN - 19711962; 8372566 AB - The cyclin-dependent kinase inhibitor p27 super(Kip1) arrests cell cycle progression through G1/S phases and is regulated by phosphorylation of serine/threonine residues. Recently, we identified the serine/threonine kinase, KIS, which phosphorylates p27 super(Kip1) on serine 10 leading to nuclear export of p27 super(Kip1) and protein degradation. However, the molecular mechanisms of transcriptional activation of the human KIS gene and its biological activity are not known. We mapped the transcription initiation site similar to 116 bp 5' to the translation start site, and sequences extending to -141 were sufficient for maximal promoter activity. Mutation in either of two Ets-binding sites in this region resulted in an approximately 75-80% decrease in promoter activity. These sites form at least 3 specific complexes, which contained GA-binding protein (GABP). Knocking down GABP alpha by siRNA in vascular smooth muscle cells (VSMCs) diminished KIS gene expression and reduced cell migration. Correspondingly, in serum stimulated GABP alpha -deficient mouse embryonic fibroblasts (MEFs), KIS gene expression was also significantly reduced, which was associated with an increase in p27 super(Kip1) protein levels and a decreased percentage of cells in S-phase. Consistent with these findings, following vascular injury in vivo, GABP alpha -heterozygous mice demonstrated reduced KIS gene expression within arterial lesions and these lesions were significantly smaller compared to GABP super(+/+) mice. In summary, serum-responsive GABP binding to Ets-binding sites activates the KIS promoter, leading to KIS gene expression, cell migration, and cell cycle progression.--Crook, M. F., Olive, M., Xue, H.-H., Langenickel, T. H., Boehm, M., Leonard, W. J., Nabel, E. G. GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression. JF - FASEB Journal AU - Crook, M F AU - Olive, M AU - Xue, H-H AU - Langenickel, TH AU - Boehm, M AU - Leonard, W J AU - Nabel, E G AD - National Heart, Lung, and Blood Institute, Bldg. 31/Rm. 5A48, 31 Center Dr., Bethesda, MD 20892, USA, nabele@nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 225 EP - 235 VL - 22 IS - 1 SN - 0892-6638, 0892-6638 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Smooth muscle KW - Olea KW - Translation KW - Molecular modelling KW - Injuries KW - Cell cycle KW - Transcription initiation KW - Gene expression KW - Nuclear transport KW - Promoters KW - Phosphorylation KW - Embryo fibroblasts KW - Cell migration KW - Serine KW - Vascular system KW - cyclin-dependent kinase inhibitors KW - Protein-serine/threonine kinase KW - siRNA KW - S phase KW - Cyclin-dependent kinase inhibitor p27 KW - Threonine KW - Mutation KW - Transcription activation KW - GA-binding protein KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19711962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+Journal&rft.atitle=GA-binding+protein+regulates+KIS+gene+expression%2C+cell+migration%2C+and+cell+cycle+progression&rft.au=Crook%2C+M+F%3BOlive%2C+M%3BXue%2C+H-H%3BLangenickel%2C+TH%3BBoehm%2C+M%3BLeonard%2C+W+J%3BNabel%2C+E+G&rft.aulast=Crook&rft.aufirst=M&rft.date=2008-01-01&rft.volume=22&rft.issue=1&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=FASEB+Journal&rft.issn=08926638&rft_id=info:doi/10.1096%2Ffj.07-8573com LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Smooth muscle; Molecular modelling; Translation; cyclin-dependent kinase inhibitors; Injuries; Protein-serine/threonine kinase; Cell cycle; Transcription initiation; Gene expression; Promoters; Nuclear transport; siRNA; Phosphorylation; S phase; Cyclin-dependent kinase inhibitor p27; Embryo fibroblasts; Cell migration; Mutation; Threonine; Transcription activation; Serine; GA-binding protein; Vascular system; Olea DO - http://dx.doi.org/10.1096/fj.07-8573com ER - TY - JOUR T1 - Transcriptional responses of murine macrophages to the adenylate cyclase toxin of Bordetella pertussis AN - 19710581; 7940190 AB - Three different recombinant forms of CyaA were used to investigate transcriptional responses of murine bone marrow-derived macrophages (BMMs) using Affymetrix Mouse Genome GeneChips super(()R). These forms were enzymically active, invasive CyaA, non-enzymically active, invasive CyaA (CyaA*) and non-enzymically active, non-invasive CyaA (proCyaA*). BMMs, treated with 20ng/ml of CyaA for 24h, showed over 1000 significant changes in gene transcription compared with control cells. CyaA caused an increase in transcription of many inflammatory genes and genes associated with various signalling cascades such as those involved in cyclic AMP-dependent protein kinase A signalling. Most strikingly, CyaA caused down-regulation of numerous genes involved in cell proliferation. CyaA* at 20ng/ml significantly up-regulated the transcription of only twelve genes after 24h whereas proCyaA* at this concentration significantly increased the transcription of only two genes. JF - Microbial Pathogenesis AU - Cheung, GYC AU - Dickinson, P AU - Sing, G AU - Craigon, M AU - Ghazal, P AU - Parton, R AU - Coote, J G AD - Institute of Biomedical and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK, cheunggo@niaid.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 61 EP - 70 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 44 IS - 1 SN - 0882-4010, 0882-4010 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Genomes KW - Pertussis KW - Protein kinase A KW - Bone marrow KW - Transcription KW - Toxins KW - Inflammation KW - Bordetella pertussis KW - Cell proliferation KW - Signal transduction KW - Adenylate cyclase KW - J 02330:Biochemistry KW - X 24490:Other KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Transcriptional+responses+of+murine+macrophages+to+the+adenylate+cyclase+toxin+of+Bordetella+pertussis&rft.au=Cheung%2C+GYC%3BDickinson%2C+P%3BSing%2C+G%3BCraigon%2C+M%3BGhazal%2C+P%3BParton%2C+R%3BCoote%2C+J+G&rft.aulast=Cheung&rft.aufirst=GYC&rft.date=2008-01-01&rft.volume=44&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2007.08.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Macrophages; Pertussis; Protein kinase A; Bone marrow; Transcription; Cell proliferation; Toxins; Inflammation; Adenylate cyclase; Signal transduction; Bordetella pertussis DO - http://dx.doi.org/10.1016/j.micpath.2007.08.007 ER - TY - JOUR T1 - Regulation of Human DAP10 Gene Expression in NK and T Cells by Ap-1 Transcription Factors AN - 19710341; 7935868 AB - Human NKG2D/DAP10 is an activation receptor expressed by NK and subsets of T cells, whose ligands include MHC class I chain-related (MIC) protein A and protein B and UL16-binding proteins that are often up-regulated by stress or pathological conditions. DAP10 is required for NKG2D/DAP10 cell surface expression and signaling capacity. Little is known about the mechanisms that regulate DAP10 gene expression. We describe the existence of multiple transcriptional start sites upstream of DAP10 exon 1 and identify the location of the basic promoter upstream of these starting sites. The promoter is active in NK and CD8 super(+) T cells, but not in CD4 super(+) T cells. We demonstrate TCR-mediated up-regulation of DAP10 transcription and found that a 40 bp region within the DAP10 promoter, containing an Ap-1 binding site, is largely responsible for this increased transcription. Using pull-down and chromatin immunoprecipitation assays, we show that the DAP10 promoter interacts with Ap-1 transcription factors in primary CD8 super(+) T and NK cells in vitro and in vivo. Overexpression of c-Jun or c-Fos in NK and T cells led to enhanced DAP10 promoter activity and DAP10 protein expression. Taken together, our data indicate that Ap-1 is an important transcription factor for regulating DAP10 gene expression in human NK and T cells, and that Ap-1 plays a key role in the transactivation of DAP10 promoter following TCR stimulation. JF - Journal of Immunology AU - Marusina, Alina I AU - Burgess, Steven J AU - Pathmanathan, Ishani AU - Borrego, Francisco AU - Coligan, John E AD - Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 409 EP - 417 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 180 IS - 1 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Cell surface KW - DAP10 protein KW - Chromatin KW - Major histocompatibility complex KW - Cell activation KW - Promoters KW - CD4 antigen KW - NKG2 antigen KW - Lymphocytes T KW - MIc protein KW - Data processing KW - DAP10 gene KW - Exons KW - double prime T-cell receptor KW - Activator protein 1 KW - protein B KW - Natural killer cells KW - Immunoprecipitation KW - Stress KW - CD8 antigen KW - c-Fos protein KW - c-Jun protein KW - Transcription factors KW - Signal transduction KW - G 07720:Immunogenetics KW - N 14835:Protein-Nucleic Acids Association KW - W 30900:Methods KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Regulation+of+Human+DAP10+Gene+Expression+in+NK+and+T+Cells+by+Ap-1+Transcription+Factors&rft.au=Marusina%2C+Alina+I%3BBurgess%2C+Steven+J%3BPathmanathan%2C+Ishani%3BBorrego%2C+Francisco%3BColigan%2C+John+E&rft.aulast=Marusina&rft.aufirst=Alina&rft.date=2008-01-01&rft.volume=180&rft.issue=1&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; Data processing; MIc protein; Chromatin; DAP10 protein; Exons; DAP10 gene; double prime T-cell receptor; protein B; Activator protein 1; Immunoprecipitation; Natural killer cells; Stress; Major histocompatibility complex; c-Fos protein; CD8 antigen; c-Jun protein; Cell activation; Promoters; CD4 antigen; NKG2 antigen; Transcription factors; Lymphocytes T; Signal transduction ER - TY - JOUR T1 - Comparative Analysis of Selenocysteine Machinery and Selenoproteome Gene Expression in Mouse Brain Identifies Neurons as Key Functional Sites of Selenium in Mammals AN - 19707833; 8038388 AB - Although dietary selenium (Se) deficiency results in phenotypes associated with selenoprotein depletion in various organs, the brain is protected from Se loss. To address the basis for the critical role of Se in brain function, we carried out comparative gene expression analyses for the complete selenoproteome and associated biosynthetic factors. Using the Allen Brain Atlas, we evaluated 159 regions of adult mouse brain and provided experimental analyses of selected selenoproteins. All 24 selenoprotein mRNAs were expressed in the mouse brain. Most strikingly, neurons in olfactory bulb, hippocampus, cerebral cortex, and cerebellar cortex were exceptionally rich in selenoprotein gene expression, in particular in GPx4, SelK, SelM, SelW, and Sep15. Over half of the selenoprotein genes were also expressed in the choroid plexus. A unique expression pattern was observed for one of the highly expressed selenoprotein genes, SelP, which we suggest to provide neurons with Se. Cluster analysis of the expression data linked certain selenoproteins and selenocysteine machinery genes and suggested functional linkages among selenoproteins, such as that between SelM and Sep15. Overall, this study suggests that the main functions of selenium in mammals are confined to certain neurons in the brain. JF - Journal of Biological Chemistry AU - Zhang, Yan AU - Zhou, You AU - Schweizer, Ulrich AU - Savaskan, Nicolai E AU - Hua, Deame AU - Kipnis, Jonathan AU - Hatfield, Dolph L AU - Gladyshev, Vadim N AD - Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588, Center for Biotechnology, University of Nebraska, Lincoln, Nebraska 68588, Neurobiology of Selenium, Neuroscience Research Center, Charite-Universitatsmedizin, 10117 Berlin, Germany, Department of Neuromorphology, Brain Research Institute, ETH & University of Zurich, Winterthurerstrasse 190 CH-8057 Zurich, Switzerland, Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, and Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 2427 EP - 2438 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 283 IS - 4 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Genetics Abstracts KW - Data processing KW - selenoproteins KW - Hippocampus KW - Cerebellum KW - Selenocysteine KW - Brain KW - Choroid plexus KW - Olfactory bulb KW - Gene expression KW - Selenium KW - Cortex KW - Atlases KW - Neurons KW - N3 11008:Neurochemistry KW - G 07870:Mammals KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19707833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Comparative+Analysis+of+Selenocysteine+Machinery+and+Selenoproteome+Gene+Expression+in+Mouse+Brain+Identifies+Neurons+as+Key+Functional+Sites+of+Selenium+in+Mammals&rft.au=Zhang%2C+Yan%3BZhou%2C+You%3BSchweizer%2C+Ulrich%3BSavaskan%2C+Nicolai+E%3BHua%2C+Deame%3BKipnis%2C+Jonathan%3BHatfield%2C+Dolph+L%3BGladyshev%2C+Vadim+N&rft.aulast=Zhang&rft.aufirst=Yan&rft.date=2008-01-01&rft.volume=283&rft.issue=4&rft.spage=2427&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - selenoproteins; Data processing; Hippocampus; Brain; Selenocysteine; Cerebellum; Choroid plexus; Olfactory bulb; Gene expression; Selenium; Cortex; Atlases; Neurons ER - TY - JOUR T1 - Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary AN - 19707037; 8521048 AB - Background The aging of reproductive organs is not only a major social issue, but of special interest in aging research. A long-standing view of 'immortal germ line versus mortal soma' poses an important question of whether the reproductive tissues age in similar ways to the somatic tissues. As a first step to understand this phenomenon, we examine global changes in gene expression patterns by DNA microarrays in ovaries and testes of C57BL/6 mice at 1, 6, 16, and 24 months of age. In addition, we compared a group of mice on ad libitum (AL) feeding with a group on lifespan-extending 40% calorie restriction (CR). Results We found that gene expression changes occurred in aging gonads, but were generally different from those in somatic organs during aging. For example, only two functional categories of genes previously associated with aging in muscle, kidney, and brain were confirmed in ovary: genes associated with complement activation were upregulated, and genes associated with mitochondrial electron transport were downregulated. The bulk of the changes in gonads were mostly related to gonad-specific functions. Ovaries showed extensive gene expression changes with age, especially in the period when ovulation ceases (from 6 to 16 months), whereas testes showed only limited age-related changes. The same trend was seen for the effects of CR: CR-mediated reversal of age-associated gene expression changes, reported in somatic organs previously, was limited to a small number of genes in gonads. Instead, in both ovary and testis, CR caused small and mostly gonad-specific effects: suppression of ovulation in ovary and activation of testis-specific genes in testis. Conclusion Overall, the results are consistent with unique modes of aging and its modification by CR in testis and ovary. JF - BMC Biology AU - Sharov, Alexei A AU - Falco, Geppino AU - Piao, Yulan AU - Poosala, Suresh AU - Becker, Kevin G AU - Zonderman, Alan B AU - Longo, Dan L AU - Schlessinger, David AU - Ko, Minoru SH AD - Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, SharovAl@grc.nia.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 24 PB - BioMed Central Ltd., Middlesex House VL - 6 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Testes KW - Feeding KW - Age KW - Aging KW - Brain KW - Muscles KW - Mitochondria KW - DNA microarrays KW - Gene expression KW - Nutrient deficiency KW - Ovulation KW - Complement activation KW - Kidney KW - Gonads KW - Reproductive organs KW - Ovaries KW - Electron transport KW - Transcription activation KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19707037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biology&rft.atitle=Effects+of+aging+and+calorie+restriction+on+the+global+gene+expression+profiles+of+mouse+testis+and+ovary&rft.au=Sharov%2C+Alexei+A%3BFalco%2C+Geppino%3BPiao%2C+Yulan%3BPoosala%2C+Suresh%3BBecker%2C+Kevin+G%3BZonderman%2C+Alan+B%3BLongo%2C+Dan+L%3BSchlessinger%2C+David%3BKo%2C+Minoru+SH&rft.aulast=Sharov&rft.aufirst=Alexei&rft.date=2008-01-01&rft.volume=6&rft.issue=&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=BMC+Biology&rft.issn=1741-7007&rft_id=info:doi/10.1186%2F1741-7007-6-24 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Feeding; Age; Aging; Muscles; Brain; Mitochondria; DNA microarrays; Gene expression; Nutrient deficiency; Ovulation; Complement activation; Kidney; Gonads; Ovaries; Reproductive organs; Electron transport; Transcription activation DO - http://dx.doi.org/10.1186/1741-7007-6-24 ER - TY - JOUR T1 - Finding sequence motifs with Bayesian models incorporating positional information: an application to transcription factor binding sites AN - 19706217; 8521031 AB - Background Biologically active sequence motifs often have positional preferences with respect to a genomic landmark. For example, many known transcription factor binding sites (TFBSs) occur within an interval [-300, 0] bases upstream of a transcription start site (TSS). Although some programs for identifying sequence motifs exploit positional information, most of them model it only implicitly and with ad hoc methods, making them unsuitable for general motif searches. Results A-GLAM, a user-friendly computer program for identifying sequence motifs, now incorporates a Bayesian model systematically combining sequence and positional information. A-GLAM's predictions with and without positional information were compared on two human TFBS datasets, each containing sequences corresponding to the interval [-2000, 0] bases upstream of a known TSS. A rigorous statistical analysis showed that positional information significantly improved the prediction of sequence motifs, and an extensive cross-validation study showed that A-GLAM's model was robust against mild misspecification of its parameters. As expected, when sequences in the datasets were successively truncated to the intervals [-1000, 0], [-500, 0] and [-250, 0], positional information aided motif prediction less and less, but never hurt it significantly. Conclusion Although sequence truncation is a viable strategy when searching for biologically active motifs with a positional preference, a probabilistic model (used reasonably) generally provides a superior and more robust strategy, particularly when the sequence motifs' positional preferences are not well characterized. JF - BMC Bioinformatics AU - Kim, Nak-Kyeong AU - Tharakaraman, Kannan AU - Marino-Ramirez, Leonardo AU - Spouge, John L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA, kimnak@ncbi.nlm.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 262 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Mathematical models KW - Bayesian analysis KW - Transcription factors KW - Statistical analysis KW - genomics KW - Bioinformatics KW - Models KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19706217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Finding+sequence+motifs+with+Bayesian+models+incorporating+positional+information%3A+an+application+to+transcription+factor+binding+sites&rft.au=Kim%2C+Nak-Kyeong%3BTharakaraman%2C+Kannan%3BMarino-Ramirez%2C+Leonardo%3BSpouge%2C+John+L&rft.aulast=Kim&rft.aufirst=Nak-Kyeong&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-262 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Computer programs; Mathematical models; Bayesian analysis; Transcription factors; Statistical analysis; Bioinformatics; genomics; Models DO - http://dx.doi.org/10.1186/1471-2105-9-262 ER - TY - JOUR T1 - SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi, microarray, and peptide-based studies AN - 19683340; 8518736 AB - Background Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant challenges for contemporary biological assays. For example, RT-PCR validation of gene expression microarray results may be unsuccessful if the two technologies target different splice variants. Effective use of sequence-based technologies requires knowledge of the specific splice variant(s) that are targeted. In addition, the critical roles of alternative splice forms in biological function and in disease suggest that assay results may be more informative if analyzed in the context of the targeted splice variant. Results A number of contemporary technologies are used for analyzing transcripts or proteins. To enable investigation of the impact of splice variation on the interpretation of data derived from those technologies, we have developed SpliceCenter. SpliceCenter is a suite of user-friendly, web-based applications that includes programs for analysis of RT-PCR primer/probe sets, effectors of RNAi, microarrays, and protein-targeting technologies. Both interactive and high-throughput implementations of the tools are provided. The interactive versions of SpliceCenter tools provide visualizations of a gene's alternative transcripts and probe target positions, enabling the user to identify which splice variants are or are not targeted. The high-throughput batch versions accept user query files and provide results in tabular form. When, for example, we used SpliceCenter's batch siRNA-Check to process the Cancer Genome Anatomy Project's large-scale shRNA library, we found that only 59% of the 50,766 shRNAs in the library target all known splice variants of the target gene, 32% target some but not all, and 9% do not target any currently annotated transcript. Conclusion SpliceCenter provides unique, user-friendly applications for assessing the impact of transcript variation on the design and interpretation of RT-PCR, RNAi, gene expression microarrays, antibody-based detection, and mass spectrometry proteomics. The tools are intended for use by bench biologists as well as bioinformaticists. JF - BMC Bioinformatics AU - Ryan, Michael C AU - Zeeberg, Barry R AU - Caplen, Natasha J AU - Cleland, James A AU - Kahn, Ari B AU - Liu, Hongfang AU - Weinstein, John N AD - Genomics & Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, mryan@tigerteamconsulting.com Y1 - 2008 PY - 2008 DA - 2008 SP - 313 PB - BioMed Central Ltd., Middlesex House VL - 9 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Data processing KW - DNA probes KW - Transcription KW - DNA microarrays KW - Cancer KW - Mass spectroscopy KW - Alternative splicing KW - RNA-mediated interference KW - Polymerase chain reaction KW - Primers KW - Peptides KW - proteomics KW - Bioinformatics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19683340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=SpliceCenter%3A+A+suite+of+web-based+bioinformatic+applications+for+evaluating+the+impact+of+alternative+splicing+on+RT-PCR%2C+RNAi%2C+microarray%2C+and+peptide-based+studies&rft.au=Ryan%2C+Michael+C%3BZeeberg%2C+Barry+R%3BCaplen%2C+Natasha+J%3BCleland%2C+James+A%3BKahn%2C+Ari+B%3BLiu%2C+Hongfang%3BWeinstein%2C+John+N&rft.aulast=Ryan&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=9&rft.issue=&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-9-313 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; DNA probes; Transcription; DNA microarrays; Mass spectroscopy; Cancer; Alternative splicing; Polymerase chain reaction; RNA-mediated interference; Peptides; Primers; Bioinformatics; proteomics DO - http://dx.doi.org/10.1186/1471-2105-9-313 ER - TY - JOUR T1 - Household cost of malaria overdiagnosis in rural Mozambique AN - 19665555; 9034881 AB - Background It is estimated that over 70% of patients with suspected malaria in sub-Saharan Africa, diagnose and manage their illness at home without referral to a formal health clinic. Of those patients who do attend a formal health clinic, malaria overdiagnosis rates are estimated to range between 30-70%. Methods This paper details an observational cohort study documenting the number and cost of repeat consultations as a result of malaria overdiagnosis at two health care providers in a rural district of Mozambique. 535 adults and children with a clinical diagnosis of malaria were enrolled and followed over a 21 day period to assess treatment regimen, symptoms, number and cost of repeat visits to health providers in patients misdiagnosed with malaria compared to those with confirmed malaria (determined by positive bloodfilm reading). Results Diagnosis based solely on clinical symptoms overdiagnosed 23% of children (&16y) and 31% of adults with malaria. Symptoms persisted (p = 0.023) and new ones developed (p & 0.001) in more adults than children in the three weeks following initial presentation. Adults overdiagnosed with malaria had more repeat visits (67% v 46%, p = 0.01-0.06) compared to those with true malaria. There was no difference in costs between patients correctly or incorrectly diagnosed with malaria. Median costs over three weeks were $0.28 for those who had one visit and $0.76 for greater than or equal to 3 visits and were proportionally highest among the poorest (p & 0.001) Conclusion Overdiagnosis of malaria results in a greater number of healthcare visits and associated cost for adult patients. Additionally, it is clear that the poorest individuals pay significantly more proportionally for their healthcare making it imperative that the treatment they receive is correct in order to prevent wastage of limited economic resources. Thus, investment in accurate malaria diagnosis and appropriate management at primary level is critical for improving health outcomes and reducing poverty. JF - Malaria Journal AU - Hume, Jen CC AU - Barnish, Guy AU - Mangal, Tara AU - Armazio, Luiz AU - Streat, Elizabeth AU - Bates, Imelda AD - Disease Control Strategy Group, Liverpool School of Tropical Medicine, Liverpool, UK, humej@niaid.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 33 PB - BioMed Central Ltd., Middlesex House VL - 7 SN - 1475-2875, 1475-2875 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Q5 01524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19665555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Household+cost+of+malaria+overdiagnosis+in+rural+Mozambique&rft.au=Hume%2C+Jen+CC%3BBarnish%2C+Guy%3BMangal%2C+Tara%3BArmazio%2C+Luiz%3BStreat%2C+Elizabeth%3BBates%2C+Imelda&rft.aulast=Hume&rft.aufirst=Jen&rft.date=2008-01-01&rft.volume=7&rft.issue=&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=14752875&rft_id=info:doi/10.1186%2F1475-2875-7-33 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1475-2875-7-33 ER - TY - JOUR T1 - Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors AN - 19648252; 8569173 AB - Dopamine's role in inhibitory control is well recognized and its disruption may contribute to behavioral disorders of discontrol such as obesity. However, the mechanism by which impaired dopamine neurotransmission interferes with inhibitory control is poorly understood. We had previously documented a reduction in dopamine D2 receptors in morbidly obese subjects. To assess if the reductions in dopamine D2 receptors were associated with activity in prefrontal brain regions implicated in inhibitory control we assessed the relationship between dopamine D2 receptor availability in striatum with brain glucose metabolism (marker of brain function) in ten morbidly obese subjects (BMI > 40 kg/m super(2)) and compared it to that in twelve non-obese controls. PET was used with [ super(11)C]raclopride to assess D2 receptors and with [ super(18)F]FDG to assess regional brain glucose metabolism. In obese subjects striatal D2 receptor availability was lower than controls and was positively correlated with metabolism in dorsolateral prefrontal, medial orbitofrontal, anterior cingulate gyrus and somatosensory cortices. In controls correlations with prefrontal metabolism were not significant but comparisons with those in obese subjects were not significant, which does not permit to ascribe the associations as unique to obesity. The associations between striatal D2 receptors and prefrontal metabolism in obese subjects suggest that decreases in striatal D2 receptors could contribute to overeating via their modulation of striatal prefrontal pathways, which participate in inhibitory control and salience attribution. The association between striatal D2 receptors and metabolism in somatosensory cortices (regions that process palatability) could underlie one of the mechanisms through which dopamine regulates the reinforcing properties of food. JF - NeuroImage AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Telang, Frank AU - Fowler, Joanna S AU - Thanos, Panayotis K AU - Logan, Jean AU - Alexoff, David AU - Ding, Yu-Shin AU - Wong, Christopher AU - Ma, Yeming AU - Pradhan, Kith AD - National Institute on Drug Abuse, Bethesda MD 20892, USA, nvolkow@nida.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 1537 EP - 1543 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 42 IS - 4 SN - 1053-8119, 1053-8119 KW - Physical Education Index; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Dopamine D2 receptors KW - Attribution KW - Food KW - Body mass KW - Blood glucose KW - Glucose metabolism KW - Neurotransmission KW - Neostriatum KW - Positron emission tomography KW - Obesity KW - Brain KW - Palatability KW - Diet KW - Cortex (somatosensory) KW - Metabolism KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19648252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Low+dopamine+striatal+D2+receptors+are+associated+with+prefrontal+metabolism+in+obese+subjects%3A+Possible+contributing+factors&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BTelang%2C+Frank%3BFowler%2C+Joanna+S%3BThanos%2C+Panayotis+K%3BLogan%2C+Jean%3BAlexoff%2C+David%3BDing%2C+Yu-Shin%3BWong%2C+Christopher%3BMa%2C+Yeming%3BPradhan%2C+Kith&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2008-01-01&rft.volume=42&rft.issue=4&rft.spage=1537&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.06.002 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Metabolism; Brain; Blood glucose; Diet; Attribution; Body mass; Dopamine D2 receptors; Neostriatum; Glucose metabolism; Cortex (somatosensory); Palatability; Positron emission tomography; Food; Neurotransmission DO - http://dx.doi.org/10.1016/j.neuroimage.2008.06.002 ER - TY - JOUR T1 - Mapping the UDP-glucuronic Acid Binding Site in UDP- glucuronosyltransferase-1A10 by Homology-Based Modeling: Confirmation with Biochemical Evidence super([dagger]) AN - 19644870; 8377959 AB - The UDP-glucuronosyltransferase (UGT) isozyme system is critical for protecting the body against endogenous and exogenous chemicals by linking glucuronic acid donated by UDP-glucuronic acid to a lipophilic acceptor substrate. UGTs convert metabolites, dietary constituents, and environmental toxicants to highly excretable glucuronides. Because of difficulties associated with purifying endoplasmic reticulum-bound UGTs for structural studies, we carried out homology-based computer modeling to aid analysis. The search found structural homology in Escherichia coli UDP-galactose 4- epimerase. Consistent with predicted similarities involving the common UDP moiety in substrate/inhibitor, UDP-glucose and UDP-hexanol amine caused competitive inhibition by Lineweaver-Burk plots. Among predicted binding sites N292, K314, K315, and K404 in UGT1A10, two informative sets of mutants K314R/Q/A/E/G and K404R/E had null activities or 2.7-fold higher/50% less activity, respectively. Scatchard analysis of binding data of the affinity ligand, 5-azidouridine-[b- super(32)P]diphosphoglucuronic acid, to purified UGT1A10-His or UGT1A7-His revealed high- and low-affinity binding sites. 2- Nitro-5-thiocyanobenzoic acid-digested UGT1A10-His bound with the radiolabeled affinity ligand revealed an 11.3 and 14.3 kDa peptide associated with K314 and K404, respectively, in a discontinuous SDS-PAGE system. Similar treatment of 1A10His-K314A bound with the ligand lacked both peptides; 1A10- HisK404R- and 1A10-HisK404E showed 1.3-fold greater and 50% less label in the 14.3 kDa peptide, respectively, compared to 1A10-His without affecting the 11.3 kDa peptide. Scatchard analysis of binding data of the affinity ligand to 1A10His-K404R and -K404E showed a 6-fold reduction and a large increase in K sub(d), respectively. Our results indicate that K314 and K404 are required UDP-glcA binding sites in 1A10, that K404 controls activity and high-affinity sites, and that K314 and K404 are strictly conserved in 70 aligned UGTs, except for S321, equivalent to K314, in UGT2B15 and 2B17 and I321 in the inactive UGT8, which suggests UGT2B15 and 2B17 contain suboptimal activity. Hence our data strongly support UDP-glcA binding to K314 and K404 in UGT1A10. JF - Biochemistry (Washington) AU - Banerjee, Rajat AU - Owens, Ida S AU - Pennington, Matthew W AU - Garza, Amanda AD - Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1830 Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 7385 EP - 7392 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 47 IS - 28 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Toxicants KW - UDP-glucuronosyltransferase KW - Metabolites KW - Lipophilic KW - amines KW - Homology KW - Scatchard analysis KW - epimerase KW - Escherichia coli KW - Isoenzymes KW - Mapping KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19644870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Mapping+the+UDP-glucuronic+Acid+Binding+Site+in+UDP-+glucuronosyltransferase-1A10+by+Homology-Based+Modeling%3A+Confirmation+with+Biochemical+Evidence+super%28%5Bdagger%5D%29&rft.au=Banerjee%2C+Rajat%3BOwens%2C+Ida+S%3BPennington%2C+Matthew+W%3BGarza%2C+Amanda&rft.aulast=Banerjee&rft.aufirst=Rajat&rft.date=2008-01-01&rft.volume=47&rft.issue=28&rft.spage=7385&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi8006127 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - amines; Data processing; Homology; Toxicants; epimerase; Scatchard analysis; UDP-glucuronosyltransferase; Isoenzymes; Metabolites; Mapping; Lipophilic; Escherichia coli DO - http://dx.doi.org/10.1021/bi8006127 ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 19637338; 8819046 AB - In addition to maintaining the GenBank(R) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data available through NCBI's web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link, Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace, Assembly, and Short Read Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus, Entrez Probe, GENSAT, Database of Genotype and Phenotype, Online Mendelian Inheritance in Man, Online Mendelian Inheritance in Animals, the Molecular Modeling Database, the Conserved Domain Database, the Conserved Domain Architecture Retrieval Tool and the PubChem suite of small molecule databases. Augmenting the web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov . JF - Nucleic Acids Research AU - Wheeler, David L AU - Barrett, Tanya AU - Benson, Dennis A AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Edgar, Ron AU - Federhen, Scott AU - Feolo, Michael AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Khovayko, Oleg AU - Landsman, David AU - Lipman, David J AU - Madden, Thomas L AU - Maglott, Donna R AU - Miller, Vadim AU - Ostell, James AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Shumway, Martin AU - Sequeira, Edwin AU - Sherry, Steven T AU - Sirotkin, Karl AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusov, Roman L AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Yaschenko, Eugene AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D13 EP - D21 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - Database issue SN - 0305-1048, 0305-1048 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - DNA probes KW - Genotypes KW - Cancer KW - Gene expression KW - Influenza KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Taxonomy KW - Protein interaction KW - V 22360:AIDS and HIV KW - G 07740:Evolution KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19637338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Wheeler%2C+David+L%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BEdgar%2C+Ron%3BFederhen%2C+Scott%3BFeolo%2C+Michael%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BKhovayko%2C+Oleg%3BLandsman%2C+David%3BLipman%2C+David+J%3BMadden%2C+Thomas+L%3BMaglott%2C+Donna+R%3BMiller%2C+Vadim%3BOstell%2C+James%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BShumway%2C+Martin%3BSequeira%2C+Edwin%3BSherry%2C+Steven+T%3BSirotkin%2C+Karl%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusov%2C+Roman+L%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BYaschenko%2C+Eugene&rft.aulast=Wheeler&rft.aufirst=David&rft.date=2008-01-01&rft.volume=36&rft.issue=Database+issue&rft.spage=D13&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkm1000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; DNA probes; Genotypes; Cancer; Influenza; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Polymerase chain reaction; Taxonomy; Protein interaction; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1093/nar/gkm1000 ER - TY - JOUR T1 - Neuropsychological testing and biomarkers in the management of brain metastases AN - 19632269; 8819635 AB - Prognosis for patients with brain metastasis remains poor. Whole brain radiation therapy is the conventional treatment option; it can improve neurological symptoms, prevent and improve tumor associated neurocognitive decline, and prevents death from neurologic causes. In addition to whole brain radiation therapy, stereotactic radiosurgery, neurosurgery and chemotherapy also are used in the management of brain metastases. Radiosensitizers are now currently being investigated as potential treatment options. All of these treatment modalities carry a risk of central nervous system (CNS) toxicity that can lead to neurocognitive impairment in long term survivors. Neuropsychological testing and biomarkers are potential ways of measuring and better understanding CNS toxicity. These tools may help optimize current therapies and develop new treatments for these patients. This article will review the current management of brain metastases, summarize the data on the CNS effects associated with brain metastases and whole brain radiation therapy in these patients, discuss the use of neuropsychological tests as outcome measures in clinical trials evaluating treatments for brain metastases, and give an overview of the potential of biomarker development in brain metastases research. JF - Radiation Oncology AU - Baschnagel, Andrew AU - Wolters, Pamela L AU - Camphausen, Kevin AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10-CRC, Room B2-3561, Bethesda, Maryland, 20892, USA, amb26@buffalo.edu Y1 - 2008 PY - 2008 DA - 2008 SP - 26 PB - BioMed Central Ltd., Middlesex House VL - 3 SN - 1748-717X, 1748-717X KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - Psychology KW - Chemotherapy KW - tumors KW - clinical trials KW - Clinical trials KW - Neurosurgery KW - Cognition KW - Metastases KW - Radiosensitizers KW - Radiation KW - Bioindicators KW - Radiation therapy KW - Mortality KW - Data processing KW - Measuring techniques KW - Brain KW - Prognosis KW - Toxicity KW - Tumors KW - biomarkers KW - chemotherapy KW - Reviews KW - R2 23020:Technological risks KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19632269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Oncology&rft.atitle=Neuropsychological+testing+and+biomarkers+in+the+management+of+brain+metastases&rft.au=Baschnagel%2C+Andrew%3BWolters%2C+Pamela+L%3BCamphausen%2C+Kevin&rft.aulast=Baschnagel&rft.aufirst=Andrew&rft.date=2008-01-01&rft.volume=3&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Radiation+Oncology&rft.issn=1748717X&rft_id=info:doi/10.1186%2F1748-717X-3-26 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Central nervous system; Data processing; Psychology; Chemotherapy; Measuring techniques; Prognosis; Brain; Tumors; Toxicity; Neurosurgery; biomarkers; Clinical trials; Cognition; Metastases; Radiosensitizers; Radiation; Reviews; Radiation therapy; Bioindicators; Mortality; tumors; clinical trials; chemotherapy DO - http://dx.doi.org/10.1186/1748-717X-3-26 ER - TY - JOUR T1 - Harnessing genetically engineered mouse models for preclinical testing AN - 19565447; 8809235 AB - Recent studies cast doubt on the value of traditionally used models as tools for testing therapies for human cancer. Although the standard practice of xenografting tumors into immunocompromised mice generates reproducible tumors, drug testing in these models has low predictive power when compared to the clinical responses in Phase II trials. The use of tumor-bearing genetically engineered mouse models holds promise for improving preclinical testing. These models recapitulate specific molecular pathways in tumor initiation or progression and provide a biological system in which to study the disease process for assessing efficacy of new therapies and proof-of-principle for testing molecularly targeted drugs. In this review, we discuss the advantages and limitations of genetically engineered mice and plausible solutions for adapting these valuable tumors for wider use in preclinical testing by transplantation into naive recipients. We also provide examples of comparative molecular analysis of mammary tumors from MMTV-Polyoma Middle-T antigen and MMTV-wnt1 models as tools for finding clinical correlates, validating existing models and guiding the development of new genetically engineered mouse models for cancer. JF - Chemico-Biological Interactions AU - Robles, Ana I AU - Varticovski, Lyuba AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Room 3060, Bethesda, MD 20892, United States, varticol@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 159 EP - 164 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 171 IS - 2 SN - 0009-2797, 0009-2797 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Breast cancer KW - Microarray KW - MMTV-PyMT KW - MMTV-wnt1 KW - Transgenics KW - Transplantation KW - Xenografts KW - Molecular modelling KW - Mammary gland KW - Genetic engineering KW - Buffers KW - Reviews KW - Animal models KW - Tumors KW - Immunosuppressive agents KW - Clinical trials KW - Cancer KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19565447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-Biological+Interactions&rft.atitle=Harnessing+genetically+engineered+mouse+models+for+preclinical+testing&rft.au=Robles%2C+Ana+I%3BVarticovski%2C+Lyuba&rft.aulast=Robles&rft.aufirst=Ana&rft.date=2008-01-01&rft.volume=171&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Chemico-Biological+Interactions&rft.issn=00092797&rft_id=info:doi/10.1016%2Fj.cbi.2007.01.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Mammary gland; Reviews; Buffers; Genetic engineering; Animal models; Tumors; Clinical trials; Immunosuppressive agents; Cancer DO - http://dx.doi.org/10.1016/j.cbi.2007.01.014 ER - TY - JOUR T1 - Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challenge AN - 19542004; 8616061 AB - Smallpox vaccination with replication deficient vaccinia strains such as Modified Vaccinia Ankara (MVA) may induce protective immunity with improved safety and tolerability profiles compared with currently available smallpox vaccines. Ninety subjects were randomized equally to six groups in a partially blinded, randomized, controlled clinical trial. IMVAMUNE (MVA-BN, Bavarian Nordic A/S, Kvistgaard, Denmark) vaccine or placebo was administered at Study Days 0 and 28 by subcutaneous or intramuscular injection and five groups were challenged with Dryvax at study Day 112. Vaccination with two doses of IMVAMUNE was safe and well tolerated compared to Dryvax. IMVAMUNE produced comparable cellular and humoral immune responses to one dose of Dryvax and the immunity induced appears robust 90 days post-vaccination by evidence of attenuated primary cutaneous reaction responses following Dryvax. IMVAMUNE vaccination prior to Dryvax reduced virus replication at the Dryvax site, decreased the size of the primary cutaneous lesion, and decreased the time to healing but did not completely ameliorate the immune response. JF - Vaccine AU - Frey, Sharon E AU - Newman, Frances K AU - Kennedy, Jeffrey S AU - Sobek, Vera AU - Ennis, Francis A AU - Hill, Heather AU - Yan, Lihan K AU - Chaplin, Paul AU - Vollmar, Jens AU - Chaitman, Bernard R AU - Belshe, Robert B AD - Department of Medicine, Saint Louis University School of Medicine and National Institute of Allergy and Infectious Diseases Vaccine Treatment and Evaluation Unit, 1100 S. Grand Blvd (DRC-8), St. Louis, MO 63104, USA, freyse@slu.edu Y1 - 2008 PY - 2008 DA - 2008 SP - 8562 EP - 8573 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 51 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - IMVAMUNE KW - MVA KW - Dryvax KW - vaccines KW - Vaccinia KW - Replication KW - Immunity KW - clinical trials KW - Clinical trials KW - Smallpox KW - Lesions KW - Denmark KW - Vaccines KW - Immune response KW - Turkey, Ankara KW - V 22350:Immunology KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19542004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Clinical+and+immunologic+responses+to+multiple+doses+of+IMVAMUNE+%28Modified+Vaccinia+Ankara%29+followed+by+Dryvax+challenge&rft.au=Frey%2C+Sharon+E%3BNewman%2C+Frances+K%3BKennedy%2C+Jeffrey+S%3BSobek%2C+Vera%3BEnnis%2C+Francis+A%3BHill%2C+Heather%3BYan%2C+Lihan+K%3BChaplin%2C+Paul%3BVollmar%2C+Jens%3BChaitman%2C+Bernard+R%3BBelshe%2C+Robert+B&rft.aulast=Frey&rft.aufirst=Sharon&rft.date=2008-01-01&rft.volume=25&rft.issue=51&rft.spage=8562&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Smallpox; Replication; Vaccinia; Immune response; Immunity; Vaccines; Clinical trials; vaccines; Lesions; clinical trials; Denmark; Turkey, Ankara DO - http://dx.doi.org/10.1016/j.vaccine.2007.10.017 ER - TY - JOUR T1 - CEBS-Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data AN - 19508217; 8742795 AB - Abstract CEBS (Chemical Effects in Biological Systems) is an integrated public repository for toxicogenomics data, including the study design and timeline, clinical chemistry and histopathology findings and microarray and proteomics data. CEBS contains data derived from studies of chemicals and of genetic alterations, and is compatible with clinical and environmental studies. CEBS is designed to permit the user to query the data using the study conditions, the subject responses and then, having identified an appropriate set of subjects, to move to the microarray module of CEBS to carry out gene signature and pathway analysis. Scope of CEBS: CEBS currently holds 22 studies of rats, four studies of mice and one study of Caenorhabditis elegans. CEBS can also accommodate data from studies of human subjects. Toxicogenomics studies currently in CEBS comprise over 4000 microarray hybridizations, and 75 2D gel images annotated with protein identification performed by MALDI and MS/MS. CEBS contains raw microarray data collected in accordance with MIAME guidelines and provides tools for data selection, pre-processing and analysis resulting in annotated lists of genes of interest. Additionally, clinical chemistry and histopathology findings from over 1500 animals are included in CEBS. CEBS/BID: The BID (Biomedical Investigation Database) is another component of the CEBS system. BID is a relational database used to load and curate study data prior to export to CEBS, in addition to capturing and displaying novel data types such as PCR data, or additional fields of interest, including those defined by the HESI Toxicogenomics Committee (in preparation). BID has been shared with Health Canada and the US Environmental Protection Agency. CEBS is available at http://cebs.niehs.nih.gov . BID can be accessed via the user interface from https://dir-apps.niehs.nih.gov/arc/ . Requests for a copy of BID and for depositing data into CEBS or BID are available at http://www.niehs.nih.gov/cebs-df/ . JF - Nucleic Acids Research AU - Waters, Michael AU - Stasiewicz, Stanley AU - Alex Merrick, B AU - Tomer, Kenneth AU - Bushel, Pierre AU - Paules, Richard AU - Stegman, Nancy AU - Nehls, Gerald AU - Yost, Kenneth J AU - Johnson, CHarris AU - Gustafson, Scott F AU - Xirasagar, Sandhya AU - Xiao, Nianqing AU - Huang, Cheng-Cheng AU - Boyer, Paul AU - Chan, Denny D AU - Pan, Qinyan AU - Gong, Hui AU - Taylor, John AU - Choi, Danielle AU - Rashid, Asif AU - Ahmed, Ayazaddin AU - Howle, Reese AU - Selkirk, James AU - Tennant, Raymond AU - Fostel, Jennifer AD - super(1)NIEHS, National Center for Toxicogenomics, PO Box 12233, Research Triangle Park, NC 27709, super(2)Science Applications International Corporation, 1710 SAIC Drive, McLean, VA 22101, super(3)Large Scale Biology Corporation, 3333 Vaca Valley Parkway, Vacaville, CA 95688, super(4)Lockheed Martin Information Technologies, PO Box 12233, Research Triangle Park, North Carolina 27709, super(5)Research Triangle Institute, PO Box 12194, Research Triangle Park, NC 27709 and super(6)Alpha Gamma Technologies, Inc., 4700 Falls of Neuse Road, Suite 350, Raleigh, NC, 27609, USA Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - D892 EP - D900 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - Database issue SN - 0305-1048, 0305-1048 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Environmental studies KW - Databases KW - Data processing KW - Caenorhabditis elegans KW - BID protein KW - Polymerase chain reaction KW - proteomics KW - Toxicity KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19508217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=CEBS-Chemical+Effects+in+Biological+Systems%3A+a+public+data+repository+integrating+study+design+and+toxicity+data+with+microarray+and+proteomics+data&rft.au=Waters%2C+Michael%3BStasiewicz%2C+Stanley%3BAlex+Merrick%2C+B%3BTomer%2C+Kenneth%3BBushel%2C+Pierre%3BPaules%2C+Richard%3BStegman%2C+Nancy%3BNehls%2C+Gerald%3BYost%2C+Kenneth+J%3BJohnson%2C+CHarris%3BGustafson%2C+Scott+F%3BXirasagar%2C+Sandhya%3BXiao%2C+Nianqing%3BHuang%2C+Cheng-Cheng%3BBoyer%2C+Paul%3BChan%2C+Denny+D%3BPan%2C+Qinyan%3BGong%2C+Hui%3BTaylor%2C+John%3BChoi%2C+Danielle%3BRashid%2C+Asif%3BAhmed%2C+Ayazaddin%3BHowle%2C+Reese%3BSelkirk%2C+James%3BTennant%2C+Raymond%3BFostel%2C+Jennifer&rft.aulast=Waters&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=36&rft.issue=Database+issue&rft.spage=D892&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkm755 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Environmental studies; Databases; Data processing; Polymerase chain reaction; BID protein; Toxicity; proteomics; Caenorhabditis elegans DO - http://dx.doi.org/10.1093/nar/gkm755 ER - TY - JOUR T1 - Lung cancer stem cells AN - 19499422; 8720072 AB - Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent differentiation, drug resistance and long lifespan relative to other cells. Stem cell signaling and differentiation pathways are maintained within distinct cancer types, and destabilization of this machinery may participate in maintenance of cancer stem cells. Characterization of lung cancer stem cells is an area of active research and is critical for developing novel therapies. This review summarizes the current knowledge on stem cell signaling pathways and cell markers used to identify the lung cancer stem cells. JF - Disease Markers AU - Pine, Sharon R AU - Marshall, Blair AU - Varticovski, Lyuba AD - Center for Cancer Research, NCI, NIH, Bethesda, MD, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 257 EP - 266 PB - IOS Press, Nieuwe Hemweg 6B VL - 24 IS - 4,5 SN - 0278-0240, 0278-0240 KW - Biotechnology and Bioengineering Abstracts KW - ABC transporters KW - drug resistance KW - hedgehog KW - notch KW - non-small cell lung cancer KW - side population KW - small cell lung cancer KW - stem cells KW - Wnt KW - Differentiation KW - Stem cells KW - Lethality KW - Data processing KW - Reviews KW - Drug resistance KW - Life span KW - Lung cancer KW - Signal transduction KW - Respiratory tract KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19499422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Disease+Markers&rft.atitle=Lung+cancer+stem+cells&rft.au=Pine%2C+Sharon+R%3BMarshall%2C+Blair%3BVarticovski%2C+Lyuba&rft.aulast=Pine&rft.aufirst=Sharon&rft.date=2008-01-01&rft.volume=24&rft.issue=4%2C5&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Disease+Markers&rft.issn=02780240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Data processing; Lethality; Drug resistance; Reviews; Life span; Respiratory tract; Signal transduction; Lung cancer ER - TY - JOUR T1 - Cell systems and the toxic mechanism(s) of alpha -synuclein AN - 19498891; 8750615 AB - Mutations in the SNCA gene are causal for familial Parkinson disease/Lewy body disease. alpha -Synuclein is a small acidic protein that binds loosely to the surface of vesicles and may play a role in synaptic dynamics, although its normal function remains somewhat unclear. What is clear is that point mutations or increased expression of wild type alpha -synuclein causes disease. A great deal of literature supports the overall hypothesis that alpha - synuclein is damaging to neurons because it is inherently prone to aggregation; mutations or increased concentration of the protein both increase this tendency. An unproven, but popular, contention is that the toxic species are small oligomers that are relatively soluble, which may react with membranes to damage key processes within the cell. The details of this process, especially in determining the order of events and the requirement of particular processes in cell death, are unclear. Derangements in vesicle processing, including synaptic function, protein turnover, mitochondrial function and oxidative stress, have all been suggested to occur. Whether there is a sequence of events or whether these are interacting effects is unclear, but the outcome is to trigger cell death, by both apoptotic and non-apoptotic mechanisms depending on the system studied. In this article, we develop a framework for thinking about alpha -synuclein in terms of initiating events and secondary processes that are required to trigger neuronal dysfunction and cell death. JF - Experimental Neurology AU - Cookson, Mark R AU - Van der Brug, Marcel AD - Laboratory of Neurogenetics, National Institute on Aging, NIH, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20982-3707, USA, Cookson@mail.nih.gov Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 5 EP - 11 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 209 IS - 1 SN - 0014-4886, 0014-4886 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Synuclein KW - Parkinson disease KW - Protein KW - Aggegation KW - Cell death KW - Apoptosis KW - Parkinson's disease KW - Point mutation KW - Mitochondria KW - Neurodegenerative diseases KW - Lewy body disease KW - Movement disorders KW - Oxidative stress KW - Neurons KW - Synaptic vesicles KW - Protein turnover KW - Vesicles KW - X 24490:Other KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19498891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Neurology&rft.atitle=Cell+systems+and+the+toxic+mechanism%28s%29+of+alpha+-synuclein&rft.au=Cookson%2C+Mark+R%3BVan+der+Brug%2C+Marcel&rft.aulast=Cookson&rft.aufirst=Mark&rft.date=2008-01-01&rft.volume=209&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Experimental+Neurology&rft.issn=00144886&rft_id=info:doi/10.1016%2Fj.expneurol.2007.05.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Synuclein; Apoptosis; Parkinson's disease; Point mutation; Mitochondria; Neurodegenerative diseases; Cell death; Lewy body disease; Movement disorders; Oxidative stress; Synaptic vesicles; Neurons; Protein turnover; Vesicles DO - http://dx.doi.org/10.1016/j.expneurol.2007.05.022 ER - TY - JOUR T1 - Diversity in penaeidin antimicrobial peptide form and function AN - 19491252; 8579901 AB - Penaeidins are a diverse family of two-domain antimicrobial peptides expressed in shrimp. Variation in penaeidin sequence results in functional diversity, which was discovered using synthetic reproductions of native penaeidins. An isoform of penaeidin class 3 from Litopenaeus setiferus (Litset Pen3-4) was synthesized using native ligation and compared directly with the synthetic penaeidin class 4 known to be expressed in the same organism. New antimicrobial activity data are included in this review that emphasize differences in effectiveness that are apparent from a direct comparison of two classes. A novel approach to intact penaeidin analysis is presented in the form of Fourier Transform Ion-Cyclotron Resonance Mass Spectrometry, which has implications for the identification of individual penaeidin isoforms without chemical modification or enzymatic cleavage. The new information included in this review helps gather the perspective on relevance of penaeidin diversity to antimicrobial function, the use of synthetic peptides as tools to evaluate specific immune functions and the application of high mass resolution, top-down sequencing methods to the intact analysis of individual penaeidin isoforms. JF - Developmental & Comparative Immunology AU - Cuthbertson, Brandon J AU - Deterding, Leesa J AU - Williams, Jason G AU - Tomer, Kenneth B AU - Etienne, Kizee AU - Blackshear, Perry J AU - Buellesbach, Erika E AU - Gross, Paul S AD - Laboratory of Signal Transduction, NIH/NIEHS, P.O. Box 12233 (MD F3-04), 111 TW Alexander Drive, Research Triangle Park, NC 27709-2233, USA, cuthbertsonb@niehs.nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 167 EP - 181 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl] VL - 32 IS - 3 SN - 0145-305X, 0145-305X KW - Northern white shrimp KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Antimicrobial peptide KW - Proline-rich KW - Cysteine-rich KW - Yeast KW - Cryptococcus KW - Candida KW - Mass spectrometry KW - MALDI-TOF MS KW - FTICR MS KW - ECD KW - Native ligation KW - Antimicrobial activity KW - Data processing KW - synthetic peptides KW - Litopenaeus setiferus KW - Pathogenic bacteria KW - Immunology KW - Disease resistance KW - Mass spectroscopy KW - Reviews KW - Species diversity KW - Reproduction KW - Peptides KW - Immune response KW - Antimicrobial peptides KW - Marine crustaceans KW - Chemical modification KW - Q1 08484:Species interactions: parasites and diseases KW - F 06935:Development, Aging & Organ Systems KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19491252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+%26+Comparative+Immunology&rft.atitle=Diversity+in+penaeidin+antimicrobial+peptide+form+and+function&rft.au=Cuthbertson%2C+Brandon+J%3BDeterding%2C+Leesa+J%3BWilliams%2C+Jason+G%3BTomer%2C+Kenneth+B%3BEtienne%2C+Kizee%3BBlackshear%2C+Perry+J%3BBuellesbach%2C+Erika+E%3BGross%2C+Paul+S&rft.aulast=Cuthbertson&rft.aufirst=Brandon&rft.date=2008-01-01&rft.volume=32&rft.issue=3&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Developmental+%26+Comparative+Immunology&rft.issn=0145305X&rft_id=info:doi/10.1016%2Fj.dci.2007.06.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Pathogenic bacteria; Immunology; Species diversity; Peptides; Disease resistance; Marine crustaceans; Antimicrobial activity; synthetic peptides; Data processing; Reviews; Reproduction; Immune response; Antimicrobial peptides; Mass spectroscopy; Chemical modification; Litopenaeus setiferus DO - http://dx.doi.org/10.1016/j.dci.2007.06.009 ER - TY - JOUR T1 - NEIBank: Genomics and bioinformatics resources for vision research AN - 19488333; 8519392 AB - NEIBank is an integrated resource for genomics and bioinformatics in vision research. It includes expressed sequence tag (EST) data and sequence-verified cDNA clones for multiple eye tissues of several species, web-based access to human eye-specific SAGE data through EyeSAGE, and comprehensive, annotated databases of known human eye disease genes and candidate disease gene loci. All expression- and disease-related data are integrated in EyeBrowse, an eye-centric genome browser. NEIBank provides a comprehensive overview of current knowledge of the transcriptional repertoires of eye tissues and their relation to pathology. JF - Molecular Vision AU - Wistow, Graeme AU - Peterson, Katherine AU - Gao, James AU - Buchoff, Patee AU - Jaworski, Cynthia AU - Bowes-Rickman, Catherine AU - Ebright, Jessica N AU - Hauser, Michael A AU - Hoover, David AD - Section on Molecular Structure and Functional Genomics, National Eye Institute, National Institutes of Health, Bethesda, MD Y1 - 2008 PY - 2008 DA - 2008 SP - 1327 EP - 1337 PB - Molecular Vision VL - 14 SN - 1090-0535, 1090-0535 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Databases KW - Data processing KW - Eye KW - Vision KW - Reviews KW - Eye diseases KW - Transcription KW - Bioinformatics KW - genomics KW - expressed sequence tags KW - W 30960:Bioinformatics & Computer Applications KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19488333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Vision&rft.atitle=NEIBank%3A+Genomics+and+bioinformatics+resources+for+vision+research&rft.au=Wistow%2C+Graeme%3BPeterson%2C+Katherine%3BGao%2C+James%3BBuchoff%2C+Patee%3BJaworski%2C+Cynthia%3BBowes-Rickman%2C+Catherine%3BEbright%2C+Jessica+N%3BHauser%2C+Michael+A%3BHoover%2C+David&rft.aulast=Wistow&rft.aufirst=Graeme&rft.date=2008-01-01&rft.volume=14&rft.issue=&rft.spage=1327&rft.isbn=&rft.btitle=&rft.title=Molecular+Vision&rft.issn=10900535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Eye; Vision; Reviews; Eye diseases; Transcription; genomics; Bioinformatics; expressed sequence tags ER - TY - JOUR T1 - Sickle Cell Trait Is Associated with a Delayed Onset of Malaria: Implications for Time-to-Event Analysis in Clinical Studies of Malaria AN - 19485806; 8585595 AB - Background. The World Health Organization (WHO) recently recommended that the time to first malaria episode serve as the primary end point in phase III malaria vaccine trials-the first of which will be held in Africa. Although common red blood cell (RBC) polymorphisms such as sickle hemoglobin (HbS) are known to protect against malaria in Africa, their impact on this end point has not been investigated. Methods. A longitudinal study of 225 individuals aged 2-25 years was conducted in Mali. The association between common RBC polymorphisms and the time to first malaria episode was evaluated. Results. Among children aged 2-10 years, sickle cell trait (HbAS) was associated with a 34-day delay in the median time to first malaria episode. Cox regression analysis showed that greater age (hazard ratio [HR], 0.87 [95% CI, 0.80- 0.94]; [image]), HbAS (HR, 0.48 [95% CI, 0.26-0.91]; [image]), and asymptomatic parasitemia at enrollment (HR, 0.35 [95% CI, 0.14-0.85]; [image]) were associated with decreased malaria risk. Conclusion. Given the delay in the time to first malaria episode associated with HbAS, it would be advisable for clinical trials and observational studies that use this end point to include Hb typing in the design of studies conducted in areas where HbAS is prevalent. JF - Journal of Infectious Diseases AU - Crompton, Peter D AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Doumbo, Safiatou AU - Ongoiba, Aissata AU - Diakite, Seidina AS AU - Krause, Michael A AU - Doumtabe, Didier AU - Kone, Younoussou AU - Weiss, Greta AU - Huang, Chiung-Yu AU - Doumbia, Seydou AU - Guindo, Aldiouma AU - Fairhurst, Rick M AU - Miller, Louis H AU - Pierce, Susan K AU - Doumbo, Ogobara K AD - Laboratory of Immunogenetics, Biostatistics Research Branch, Laboratory of Malaria and Vector Research, and Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, pcrompton@niaid.nih.gov Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 1265 EP - 1275 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu] VL - 198 IS - 9 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Age KW - Human diseases KW - Mali KW - Erythrocytes KW - Disease control KW - Malaria KW - Children KW - Clinical trials KW - Public health KW - Hemoglobin KW - parasitemia KW - Typing KW - Infectious diseases KW - Regression analysis KW - Vaccines KW - Haemoglobins KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19485806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Sickle+Cell+Trait+Is+Associated+with+a+Delayed+Onset+of+Malaria%3A+Implications+for+Time-to-Event+Analysis+in+Clinical+Studies+of+Malaria&rft.au=Crompton%2C+Peter+D%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BDoumbo%2C+Safiatou%3BOngoiba%2C+Aissata%3BDiakite%2C+Seidina+AS%3BKrause%2C+Michael+A%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BWeiss%2C+Greta%3BHuang%2C+Chiung-Yu%3BDoumbia%2C+Seydou%3BGuindo%2C+Aldiouma%3BFairhurst%2C+Rick+M%3BMiller%2C+Louis+H%3BPierce%2C+Susan+K%3BDoumbo%2C+Ogobara+K&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2008-01-01&rft.volume=198&rft.issue=9&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F592224 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Human diseases; Infectious diseases; Erythrocytes; Disease control; Malaria; Vaccines; Haemoglobins; Public health; Hemoglobin; Age; parasitemia; Typing; Regression analysis; Children; Clinical trials; Mali DO - http://dx.doi.org/10.1086/592224 ER - TY - JOUR T1 - iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease AN - 19484706; 8517174 AB - Alzheimer's disease (AD) is characterized by progressive cognitive impairment associated with accumulation of amyloid beta -peptide, synaptic degeneration and the death of neurons in the hippocampus, and temporal, parietal and frontal lobes of the cerebral cortex. Analysis of postmortem brain tissue from AD patients can provide information on molecular alterations present at the end of the disease process, but cannot discriminate between changes that are specifically involved in AD versus those that are simply a consequence of neuronal degeneration. Animal models of AD provide the opportunity to elucidate the molecular changes that occur in brain cells as the disease process is initiated and progresses. To this end, we used the 3xTgAD mouse model of AD to gain insight into the complex alterations in proteins that occur in the hippocampus and cortex in AD. The 3xTgAD mice express mutant presenilin-1, amyloid precursor protein and tau, and exhibit AD-like amyloid and tau pathology in the hippocampus and cortex, and associated cognitive impairment. Using the iTRAQ stable-isotope-based quantitative proteomic technique, we performed an in-depth proteomic analysis of hippocampal and cortical tissue from 16 month old 3xTgAD and non-transgenic control mice. We found that the most important groups of significantly altered proteins included those involved in synaptic plasticity, neurite outgrowth and microtubule dynamics. Our findings have elucidated some of the complex proteome changes that occur in a mouse model of AD, which could potentially illuminate novel therapeutic avenues for the treatment of AD and other neurodegenerative disorders. JF - PLoS ONE AU - Martin, Bronwen AU - Brenneman, Randall AU - Becker, Kevin G AU - Gucek, Marjan AU - Cole, Robert N AU - Maudsley, Stuart AU - Lashuel, Hilal AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Biomedical Research Center, Baltimore, Maryland, United States of America Y1 - 2008 PY - 2008 DA - 2008 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 3 IS - 7 SN - 1932-6203, 1932-6203 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Microtubules KW - Hippocampus KW - Alzheimer's disease KW - Brain KW - Animal models KW - Plasticity (synaptic) KW - Neurodegeneration KW - Amyloid precursor protein KW - Neurodegenerative diseases KW - Cortex KW - Presenilin 1 KW - Frontal lobe KW - Cognitive ability KW - Neurons KW - Tau protein KW - Axonogenesis KW - proteomics KW - beta -Amyloid KW - Amyloid KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19484706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=iTRAQ+Analysis+of+Complex+Proteome+Alterations+in+3xTgAD+Alzheimer%27s+Mice%3A+Understanding+the+Interface+between+Physiology+and+Disease&rft.au=Martin%2C+Bronwen%3BBrenneman%2C+Randall%3BBecker%2C+Kevin+G%3BGucek%2C+Marjan%3BCole%2C+Robert+N%3BMaudsley%2C+Stuart%3BLashuel%2C+Hilal&rft.aulast=Martin&rft.aufirst=Bronwen&rft.date=2008-01-01&rft.volume=3&rft.issue=7&rft.spage=e2750&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0002750 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Microtubules; Hippocampus; Alzheimer's disease; Animal models; Brain; Plasticity (synaptic); Neurodegeneration; Amyloid precursor protein; Neurodegenerative diseases; Cortex; Presenilin 1; Cognitive ability; Frontal lobe; Neurons; Tau protein; Axonogenesis; beta -Amyloid; proteomics; Amyloid DO - http://dx.doi.org/10.1371/journal.pone.0002750 ER - TY - JOUR T1 - A Chemical Sensor That Can Detect the Frequency of Ultrasound AN - 19474903; 8134839 AB - Herein is described a chemical sensor that can detect the frequency of ultrasound. Exposure of aqueous n-alkyl sulfate or sulfonate surfactant solutions to high-intensity ultrasound results in the formation of secondary carbon-centered radicals. The yield of these radicals reaches a maximum plateau, the magnitude of which is limited by the dynamic ability of the surfactant to accumulate at the rapidly oscillating gas/solution interface of cavitation bubbles. For this reason, the maximum plateau yield observed following sonolysis of sodium butane sulfonate solutions compared to that of sodium dodecyl sulfate solutions (i.e., CH sub(SBSo)/CH sub(SDS)) was greater than 1. Interestingly, it was found that the CH sub(SBSo)/CH sub(SDS) ratio had a linear dependence on ultrasound frequency. Since it is known from earlier studies that the CH sub(SBSo)/CH sub(SDS) ratio is independent of ultrasound intensity and of the geometry of flat plate exposure systems, a plot of the CH sub(SBSo)/CH sub(SDS) ratio against ultrasound frequency yields a calibration curve. With this calibration curve, the CH sub(SBSo)/CH sub(SDS) ratio can be used to detect the frequency of ultrasound in flat plate transducer systems. The effect can best be described in terms of the dynamic surface tension of surfactants in relation to the influence of ultrasound frequency on the lifetime of the gas/solution interface of sonochemically active cavitation bubbles. JF - Journal of the American Chemical Society AU - Sostaric, Joe Z AD - Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, sostaric.2@osu.edu Y1 - 2008///0, PY - 2008 DA - 0, 2008 SP - 3248 EP - 3249 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 130 IS - 11 SN - 1272-7863, 1272-7863 KW - Biotechnology and Bioengineering Abstracts KW - Sodium KW - Butane KW - Cavitation KW - Ultrasound KW - Surfactants KW - Radicals KW - Chemical sensors KW - Sulfate KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19474903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=A+Chemical+Sensor+That+Can+Detect+the+Frequency+of+Ultrasound&rft.au=Sostaric%2C+Joe+Z&rft.aulast=Sostaric&rft.aufirst=Joe&rft.date=2008-01-01&rft.volume=130&rft.issue=11&rft.spage=3248&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=12727863&rft_id=info:doi/10.1021%2Fja077311vPII%3AS0002-7863%2807%2907311-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Sodium; Butane; Cavitation; Surfactants; Ultrasound; Sulfate; Chemical sensors; Radicals DO - http://dx.doi.org/10.1021/ja077311vPII:S0002-7863(07)07311-8 ER - TY - JOUR T1 - How Large a Training Set is Needed to Develop a Classifier for Microarray Data? AN - 19470663; 7933853 AB - PURPOSE: A common goal of gene expression microarray studies is the development of a classifier that can be used to divide patients into groups with different prognoses, or with different expected responses to a therapy. These types of classifiers are developed on a training set, which is the set of samples used to train a classifier. The question of how many samples are needed in the training set to produce a good classifier from high-dimensional microarray data is challenging. Experimental Design: We present a model-based approach to determining the sample size required to adequately train a classifier. RESULTS: It is shown that sample size can be determined from three quantities: standardized fold change, class prevalence, and number of genes or features on the arrays. Numerous examples and important experimental design issues are discussed. The method is adapted to address ex post facto determination of whether the size of a training set used to develop a classifier was adequate. An interactive web site for performing the sample size calculations is provided. CONCLUSION: We showed that sample size calculations for classifier development from high-dimensional microarray data are feasible, discussed numerous important considerations, and presented examples. JF - Clinical Cancer Research AU - Dobbin, Kevin K AU - Zhao, Yingdong AU - Simon, Richard M AD - Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Rockville, Maryland Y1 - 2008/01/01/ PY - 2008 DA - 2008 Jan 01 SP - 108 EP - 114 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 14 IS - 1 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - DNA microarrays KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19470663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=How+Large+a+Training+Set+is+Needed+to+Develop+a+Classifier+for+Microarray+Data%3F&rft.au=Dobbin%2C+Kevin+K%3BZhao%2C+Yingdong%3BSimon%2C+Richard+M&rft.aulast=Dobbin&rft.aufirst=Kevin&rft.date=2008-01-01&rft.volume=14&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; DNA microarrays ER - TY - JOUR T1 - Antibody Profiling by Proteome Microarray Reveals the Immunogenicity of the Attenuated Smallpox Vaccine Modified Vaccinia Virus Ankara Is Comparable to That of Dryvax AN - 19470636; 7936492 AB - Modified vaccinia virus Ankara (MVA) is a highly attenuated vaccinia virus that is under consideration as an alternative to the conventional smallpox vaccine Dryvax. MVA was attenuated by extensive passage of vaccinia virus Ankara in chicken embryo fibroblasts. Several immunomodulatory genes and genes that influence host range are deleted or mutated, and replication is aborted in the late stage of infection in most nonavian cells. The effect of these mutations on immunogenicity is not well understood. Since the structural genes appear to be intact in MVA, it is hypothesized that critical targets for antibody neutralization have been retained. To test this, we probed microarrays of the Western Reserve (WR) proteome with sera from humans and macaques after MVA and Dryvax vaccination. As most protein sequences of MVA are 97 to 99% identical to those of other vaccinia virus strains, extensive binding cross-reactivity is expected, except for those deleted or truncated. Despite different hosts and immunization regimens, the MVA and Dryvax antibody profiles were broadly similar, with antibodies against membrane and core proteins being the best conserved. The responses to nonstructural proteins were less well conserved, although these are not expected to influence virus neutralization. The broadest antibody response was obtained for hyperimmune rabbits with WR, which is pathogenic in rabbits. These data indicate that, despite the mutations and deletions in MVA, its overall immunogenicity is broadly comparable to that of Dryvax, particularly at the level of antibodies to membrane proteins. The work supports other information suggesting that MVA may be a useful alternative to Dryvax. JF - Journal of Virology AU - Davies, DHuw AU - Wyatt, Linda S AU - Newman, Frances K AU - Earl, Patricia L AU - Chun, Sookhee AU - Hernandez, Jenny E AU - Molina, Douglas M AU - Hirst, Siddiqua AU - Moss, Bernard AU - Frey, Sharon E AU - Felgner, Philip L AD - Division of Infectious Diseases, Department of Medicine, Hewitt Hall, University of California, Irvine, California 92697. Laboratory of Viral Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892. Division of Infectious Diseases and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri 63110. ImmPORT Therapeutics Inc., Irvine, California 92618 Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 652 EP - 663 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 82 IS - 2 SN - 0022-538X, 0022-538X KW - Macaques KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Host range KW - Cross-reactivity KW - Data processing KW - Replication KW - Macaca KW - Antibody response KW - Membrane proteins KW - Infection KW - Vaccination KW - Smallpox KW - Vaccinia virus KW - Immunogenicity KW - Embryo fibroblasts KW - Nonstructural proteins KW - Vaccines KW - Mutation KW - Core protein KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19470636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Antibody+Profiling+by+Proteome+Microarray+Reveals+the+Immunogenicity+of+the+Attenuated+Smallpox+Vaccine+Modified+Vaccinia+Virus+Ankara+Is+Comparable+to+That+of+Dryvax&rft.au=Davies%2C+DHuw%3BWyatt%2C+Linda+S%3BNewman%2C+Frances+K%3BEarl%2C+Patricia+L%3BChun%2C+Sookhee%3BHernandez%2C+Jenny+E%3BMolina%2C+Douglas+M%3BHirst%2C+Siddiqua%3BMoss%2C+Bernard%3BFrey%2C+Sharon+E%3BFelgner%2C+Philip+L&rft.aulast=Davies&rft.aufirst=DHuw&rft.date=2008-01-01&rft.volume=82&rft.issue=2&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Cross-reactivity; Host range; Replication; Membrane proteins; Antibody response; Infection; Vaccination; Smallpox; Immunogenicity; Nonstructural proteins; Embryo fibroblasts; Vaccines; Mutation; Core protein; Vaccinia virus; Macaca ER - TY - JOUR T1 - Targeted Immunotherapy for Staphylococcal Infections: Focus on Anti- MSCRAMM Antibodies AN - 19386328; 7964467 AB - Staphylococcal infections represent an enormous burden to the public health system in the US and worldwide. While traditionally restricted to the hospital setting, highly virulent strains have recently emerged that may cause severe, even fatal, disease in healthy adults outside healthcare settings. This situation, together with the increasing resistance to many antibacterials in a wide variety of staphylococcal strains, requires that vaccine development for staphylococcal diseases be re-evaluated. Finding a vaccine for staphylococci is not trivial, as protective immunity to staphylococcal infections does not appear to exist at a significant degree, which may be partly due to the fact that our immune system is in constant contact with staphylococcal antigens and many strains are commensal organisms on human epithelia. Furthermore, the most virulent species, Staphylococcus aureus, produces protein A, a powerful means to evade acquired host defense. While two high-profile vaccine preparations have failed clinical trials within the last few years, promising results from novel approaches based on the combination of systematically selected antigens have been reported. These combinatory vaccines target microbial surface components recognizing adhesive matrix molecules (MSCRAMMs), a family of bacterial proteins that bind to human extracellular matrix components. In addition, polysaccharide and other nonprotein antigens may represent suitable vaccine targets on the staphylococcal cell surface. JF - BioDrugs AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Hamilton, Montana, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 27 EP - 36 PB - Adis International Ltd., 41 Centorian Drive Private Bay 65901, Mairangi Bay Auckland 10 New Zealand, [mailto:sportsmed@adis.co.nz], [URL:http://www.adis.com] VL - 22 IS - 1 SN - 1173-8804, 1173-8804 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Immunotherapies KW - Research and development KW - Staphylococcal infections KW - Staphylococcal vaccine KW - Cell surface KW - protein A KW - Immunotherapy KW - Immune system KW - Commensals KW - Immunity KW - Polysaccharides KW - Infection KW - Clinical trials KW - Public health KW - Antibodies KW - Extracellular matrix KW - Vaccines KW - Staphylococcus aureus KW - Adhesives KW - Hospitals KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30915:Pharmaceuticals & Vaccines KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19386328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioDrugs&rft.atitle=Targeted+Immunotherapy+for+Staphylococcal+Infections%3A+Focus+on+Anti-+MSCRAMM+Antibodies&rft.au=Otto%2C+Michael&rft.aulast=Otto&rft.aufirst=Michael&rft.date=2008-01-01&rft.volume=22&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=BioDrugs&rft.issn=11738804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; Immune system; Immunotherapy; protein A; Commensals; Immunity; Infection; Polysaccharides; Clinical trials; Public health; Antibodies; Extracellular matrix; Vaccines; Adhesives; Hospitals; Staphylococcus aureus ER - TY - JOUR T1 - Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis AN - 19355924; 8739853 AB - Background Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HSC mobilization include G-CSF and the CXCR4 inhibitor AMD3100 (plerixafor). The HSCs cells mobilized by each agent may contain different subtypes and have different functions. To characterize mobilized HSCs used for clinical applications, microRNA (miRNA) profiling and gene expression profiling were used to compare AMD3100-mobilized CD133+ cells from 4 subjects, AMD3100 plus G-CSF-mobilized CD133+ cells from 4 subjects and G-CSF-mobilized CD34+ cells from 5 subjects. The HSCs were compared to peripheral blood leukocytes (PBLs) from 7 subjects. Results Hierarchical clustering of miRNAs separated HSCs from PBLs. miRNAs up-regulated in all HSCs included hematopoiesis-associated miRNA; miR-126, miR-10a, miR-221 and miR-17-92 cluster. miRNAs up-regulated in PBLs included miR-142-3p, -218, -21, and -379. Hierarchical clustering analysis of miRNA expression separated the AMD3100-mobilized CD133+ cells from G-CSF-mobilized CD34+ cells. Gene expression analysis of the HSCs naturally segregated samples according to mobilization and isolation protocol and cell differentiation status. Conclusion HSCs and PBLs have unique miRNA and gene expression profiles. miRNA and gene expression microarrays maybe useful for assessing differences in HSCs. JF - Journal of Translational Medicine AU - Jin, Ping AU - Wang, Ena AU - Ren, Jiaqiang AU - Childs, Richard AU - Shin, Jeong Won AU - Khuu, Hanh AU - Marincola, Francesco M AU - Stroncek, David F AD - Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA, pjin@cc.nih.gov Y1 - 2008 PY - 2008 DA - 2008 SP - 39 PB - BioMed Central Ltd., Middlesex House VL - 6 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Translation KW - CXCR4 protein KW - Immunotherapy KW - Leukocytes KW - miRNA KW - Therapeutic applications KW - CD34 antigen KW - Peripheral blood KW - Granulocyte colony-stimulating factor KW - DNA microarrays KW - Gene expression KW - Differentiation KW - Stem cells KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19355924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Translational+Medicine&rft.atitle=Differentiation+of+two+types+of+mobilized+peripheral+blood+stem+cells+by+microRNA+and+cDNA+expression+analysis&rft.au=Jin%2C+Ping%3BWang%2C+Ena%3BRen%2C+Jiaqiang%3BChilds%2C+Richard%3BShin%2C+Jeong+Won%3BKhuu%2C+Hanh%3BMarincola%2C+Francesco+M%3BStroncek%2C+David+F&rft.aulast=Jin&rft.aufirst=Ping&rft.date=2008-01-01&rft.volume=6&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Translational+Medicine&rft.issn=1479-5876&rft_id=info:doi/10.1186%2F1479-5876-6-39 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Translation; CXCR4 protein; Immunotherapy; miRNA; Leukocytes; Therapeutic applications; Peripheral blood; CD34 antigen; Granulocyte colony-stimulating factor; DNA microarrays; Gene expression; Differentiation; Stem cells DO - http://dx.doi.org/10.1186/1479-5876-6-39 ER - TY - JOUR T1 - Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice AN - 19295462; 8152661 AB - 4-Methylimidazole (4MI) is used in the manufacture of pharmaceuticals, photographic chemicals, dyes and pigments, cleaning and agricultural chemicals, and rubber. It has been identified as a by-product of fermentation in foods and has been detected in mainstream and side stream tobacco smoke. 4MI was studied because of its high potential for human exposure. Groups of 50 male and 50 female F344/N rats were fed diets containing 0-, 625-, 1,250-, or 2,500 ppm 4MI (males) or 0-, 1,250-, 2,500-, or 5,000 ppm 4MI (females) for 106 weeks. Based on the food consumption the calculated average daily doses were approximately 30, 55, or 115 mg 4MI/kg body weight to males and 60, 120, or 250 mg 4MI/kg to females. Survival of all exposed groups of males and females was similar to that of the control groups. The mean body weights of males in the 1,250- and 2,500 ppm groups and females in the 2,500- and 5,000 ppm groups were less than those of the control groups throughout the study. Feed consumption by 5,000 ppm females was less than that by the controls. Clonic seizures, excitability, hyperactivity, and impaired gait were observed primarily in 2,500- and 5,000 ppm females. The incidence of mononuclear cell leukemia in the 5,000 ppm females was significantly greater than that in the controls. The incidences of hepatic histiocytosis, chronic inflammation, and focal fatty change were significantly increased in all exposed groups of male and female rats. The incidences of hepatocellular eosinophilic and mixed cell foci were significantly increased in 2,500 ppm males and 5,000 ppm females. Groups of 50 male and 50 female B6C3F1 mice were fed diets containing 0-, 312-, 625-, or 1,250 ppm 4MI for 106 weeks. Based on the food consumption the calculated average daily doses were approximately 40, 80, or 170 mg 4MI/kg body weight to males and females. Survival of all exposed groups of males and females was similar to that of the control groups. Mean body weights of males and females in the 1,250 ppm groups and that in the 312- and 625 ppm females were less than those of the control groups. Feed consumption by exposed groups of male and female mice was similar to that by the controls. The incidences of alveolar/bronchiolar adenoma in all exposed groups of females, alveolar/bronchiolar carcinoma in 1,250 ppm males, and alveolar/bronchiolar adenoma or carcinoma (combined) in 1,250 ppm males and 625- and 1,250 ppm females were significantly greater than those in the control groups. The incidence of alveolar epithelial hyperplasia was significantly increased in the 1,250 ppm females. 4MI is carcinogenic inducing alveolar/bronchiolar adenoma and carcinoma in male and female mice. 4MI may also induce mononuclear cell leukemia in female rats. JF - Archives of Toxicology AU - Chan, P C AU - Hills, G D AU - Kissling, GE AU - Nyska, A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA, chanp@niehs.nih.gov Y1 - 2008/01// PY - 2008 DA - January 2008 SP - 45 EP - 53 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de] VL - 82 IS - 1 SN - 0340-5761, 0340-5761 KW - Biotechnology and Bioengineering Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts KW - Fermentation KW - Byproducts KW - Survival KW - Excitability KW - Streams KW - Leukemia KW - Food consumption KW - Histiocytosis KW - Body weight KW - Carcinogenicity KW - Pigments KW - Tobacco KW - gait KW - Toxicology KW - Diets KW - Leukocytes (mononuclear) KW - Fermented food KW - Seizures KW - Rubber KW - Toxicity KW - Alveoli KW - Inflammation KW - Carcinoma KW - Smoke KW - Hyperplasia KW - Dyes KW - Liver KW - Pharmaceuticals KW - Feeding experiments KW - Adenoma KW - Tumours KW - Hyperactivity KW - X 24310:Pharmaceuticals KW - Q5 08505:Prevention and control KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19295462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=Toxicity+and+carcinogenicity+studies+of+4-methylimidazole+in+F344%2FN+rats+and+B6C3F1+mice&rft.au=Chan%2C+P+C%3BHills%2C+G+D%3BKissling%2C+GE%3BNyska%2C+A&rft.aulast=Chan&rft.aufirst=P&rft.date=2008-01-01&rft.volume=82&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-007-0222-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Food consumption; Dyes; Body weight; Fermentation; Byproducts; Feeding experiments; Toxicity; Tumours; Toxicology; Survival; Excitability; Streams; Leukemia; Histiocytosis; Carcinogenicity; Pigments; Tobacco; gait; Diets; Leukocytes (mononuclear); Fermented food; Seizures; Rubber; Alveoli; Carcinoma; Inflammation; Smoke; Hyperplasia; Liver; Pharmaceuticals; Adenoma; Hyperactivity DO - http://dx.doi.org/10.1007/s00204-007-0222-5 ER - TY - JOUR T1 - Role of Hypermutability in the Evolution of the Genus Oenococcus AN - 19294778; 8038061 AB - Oenococcus oeni is an alcohol-tolerant, acidophilic lactic acid bacterium primarily responsible for malolactic fermentation in wine. A recent comparative genomic analysis of O. oeni PSU-1 with other sequenced lactic acid bacteria indicates that PSU-1 lacks the mismatch repair (MMR) genes mutS and mutL. Consistent with the lack of MMR, mutation rates for O. oeni PSU-1 and a second oenococcal species, O. kitaharae, were higher than those observed for neighboring taxa, Pediococcus pentosaceus and Leuconostoc mesenteroides. Sequence analysis of the rpoB mutations in rifampin-resistant strains from both oenococcal species revealed a high percentage of transition mutations, a result indicative of the lack of MMR. An analysis of common alleles in the two sequenced O. oeni strains, PSU-1 and BAA-1163, also revealed a significantly higher level of transition substitutions than were observed in other Lactobacillales species. These results suggest that the genus Oenococcus is hypermutable due to the loss of mutS and mutL, which occurred with the divergence away from the neighboring Leuconostoc branch. The hypermutable status of the genus Oenococcus explains the observed high level of allelic polymorphism among known O. oeni isolates and likely contributed to the unique adaptation of this genus to acidic and alcoholic environments. JF - Journal of Bacteriology AU - Marcobal, Angela M AU - Sela, David A AU - Wolf, Yuri I AU - Makarova, Kira S AU - Mills, David A AD - Robert Mondavi Institute for Wine and Food Sciences, Department of Viticulture and Enology, University of California, Davis, California. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland Y1 - 2008/01// PY - 2008 DA - Jan 2008 SP - 564 EP - 570 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 190 IS - 2 SN - 0021-9193, 0021-9193 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - mismatch repair KW - Adaptations KW - Lactic acid bacteria KW - Mutation rates KW - Alcoholics KW - Leuconostoc KW - Malolactic fermentation KW - Oenococcus oeni KW - Genomic analysis KW - Lactic acid KW - Leuconostoc mesenteroides KW - Pediococcus pentosaceus KW - Vitaceae KW - Evolution KW - RpoB protein KW - Oenococcus KW - Wine KW - J 02310:Genetics & Taxonomy KW - W 30935:Food Biotechnology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19294778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+Hypermutability+in+the+Evolution+of+the+Genus+Oenococcus&rft.au=Marcobal%2C+Angela+M%3BSela%2C+David+A%3BWolf%2C+Yuri+I%3BMakarova%2C+Kira+S%3BMills%2C+David+A&rft.aulast=Marcobal&rft.aufirst=Angela&rft.date=2008-01-01&rft.volume=190&rft.issue=2&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Malolactic fermentation; Adaptations; mismatch repair; Genomic analysis; Lactic acid; Lactic acid bacteria; Mutation rates; Alcoholics; RpoB protein; Evolution; Wine; Leuconostoc; Oenococcus oeni; Vitaceae; Pediococcus pentosaceus; Leuconostoc mesenteroides; Oenococcus ER - TY - JOUR T1 - Mesenchymal stem cells in arthritic diseases AN - 19290076; 8746636 AB - Mesenchymal stem cells (MSCs), the nonhematopoietic progenitor cells found in various adult tissues, are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic use. These properties make MSCs an ideal candidate cell type as building blocks for tissue engineering efforts to regenerate replacement tissues and repair damaged structures as encountered in various arthritic conditions. Osteoarthritis (OA) is the most common arthritic condition and, like rheumatoid arthritis (RA), presents an inflammatory environment with immunological involvement and this has been an enduring obstacle that can potentially limit the use of cartilage tissue engineering. Recent advances in our understanding of the functions of MSCs have shown that MSCs also possess potent immunosuppression and anti-inflammation effects. In addition, through secretion of various soluble factors, MSCs can influence the local tissue environment and exert protective effects with an end result of effectively stimulating regeneration in situ. This function of MSCs can be exploited for their therapeutic application in degenerative joint diseases such as RA and OA. This review surveys the advances made in the past decade which have led to our current understanding of stem cell biology as relevant to diseases of the joint. The potential involvement of MSCs in the pathophysiology of degenerative joint diseases will also be discussed. Specifically, we will explore the potential of MSC-based cell therapy of OA and RA by means of functional replacement of damaged cartilage via tissue engineering as well as their anti-inflammatory and immunosuppressive activities. JF - Arthritis Research & Therapy AU - Chen, F H AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Building 50, 50 South Dr., Bethesda, MD 20892, USA Y1 - 2008 PY - 2008 DA - 2008 SP - 223 VL - 10 IS - 5 SN - 1478-6354, 1478-6354 KW - Biotechnology and Bioengineering Abstracts KW - Cartilage diseases KW - Osteoarthritis KW - Joint diseases KW - Therapeutic applications KW - Cell culture KW - Inflammation KW - Differentiation KW - Rheumatoid arthritis KW - Stem cells KW - Reviews KW - Mesenchyme KW - Immunosuppression KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19290076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Mesenchymal+stem+cells+in+arthritic+diseases&rft.au=Chen%2C+F+H%3BTuan%2C+R+S&rft.aulast=Chen&rft.aufirst=F&rft.date=2008-01-01&rft.volume=10&rft.issue=5&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2514 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stem cells; Osteoarthritis; Joint diseases; Inflammation; Mesenchyme; Cartilage diseases; Reviews; Differentiation; Cell culture; Therapeutic applications; Immunosuppression; Rheumatoid arthritis DO - http://dx.doi.org/10.1186/ar2514 ER - TY - JOUR T1 - Mud-trapped herd captures evidence of distinctive dinosaur sociality AN - 1244675100; 2013-006362 JF - Acta Palaeontologica Polonica AU - Varricchio, David J AU - Sereno, Paul C AU - Zhao, Xijin AU - Tan, Lin AU - Wilson, Jeffery A AU - Lyon, Gabrielle H Y1 - 2008 PY - 2008 DA - 2008 SP - 567 EP - 578 PB - Panstwowe Wydawnictwo Naukowe, Warsaw VL - 53 IS - 4 SN - 0567-7920, 0567-7920 KW - Inner Mongolia China KW - Diapsida KW - Chordata KW - Far East KW - communities KW - Cretaceous KW - behavior KW - Gobi Desert KW - Mesozoic KW - herding KW - Reptilia KW - Archosauria KW - mires KW - Sinornithomimus dongi KW - Sinornithomimus KW - taphonomy KW - dinosaurs KW - Vertebrata KW - Asia KW - Tetrapoda KW - China KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1244675100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Palaeontologica+Polonica&rft.atitle=Mud-trapped+herd+captures+evidence+of+distinctive+dinosaur+sociality&rft.au=Varricchio%2C+David+J%3BSereno%2C+Paul+C%3BZhao%2C+Xijin%3BTan%2C+Lin%3BWilson%2C+Jeffery+A%3BLyon%2C+Gabrielle+H&rft.aulast=Varricchio&rft.aufirst=David&rft.date=2008-01-01&rft.volume=53&rft.issue=4&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Acta+Palaeontologica+Polonica&rft.issn=05677920&rft_id=info:doi/10.4202%2Fapp.2008.0402 L2 - http://app.pan.pl/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. Reference includes data supplied by Panstwowy Instytut Geologiczny, Warsaw, Poland N1 - Date revised - 2013-01-01 N1 - Number of references - 73 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-12-27 N1 - CODEN - APGPAC N1 - SubjectsTermNotLitGenreText - Archosauria; Asia; behavior; China; Chordata; communities; Cretaceous; Diapsida; dinosaurs; Far East; Gobi Desert; herding; Inner Mongolia China; Mesozoic; mires; Reptilia; Sinornithomimus; Sinornithomimus dongi; taphonomy; Tetrapoda; Vertebrata DO - http://dx.doi.org/10.4202/app.2008.0402 ER -